Sync corticalclock
Browse files- README.md +38 -0
- config.json +36 -0
- corticalclock.pt +3 -0
README.md
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---
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license: bsd-3-clause
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library_name: pyaging
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tags:
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- pyaging
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- aging-clock
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- biology
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- dna-methylation
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---
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# corticalclock
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Cortex-specific DNA-methylation chronological-age estimator trained by elastic net on 1,047 post-mortem cortical samples; its 347-CpG weighted score is back-transformed to years.
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|---|---|
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| **Predicts** | chronological age |
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| **Species** | Homo sapiens |
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| **Tissue** | brain cortex |
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| **Data type** | DNA methylation |
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| **Model type** | elastic net regression |
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| **Year** | 2020 |
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## Use with pyaging
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```python
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import pyaging as pya
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pya.pred.predict_age(adata, ["corticalclock"])
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```
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Browse every clock in the [pyaging Clock Catalogue](https://pyaging.readthedocs.io).
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## Citation
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Shireby, G. L., et al. "Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex." Brain 143.12 (2020): 3763-3775.
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https://doi.org/10.1093/brain/awaa334
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config.json
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{
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"approved_by_author": "\u231b",
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"citation": "Shireby, G. L., et al. \"Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex.\" Brain 143.12 (2020): 3763-3775.",
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"citations": 206,
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"citations_date": "2026-07-05",
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"clock_name": "corticalclock",
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"data_type": "DNA methylation",
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"doi": "https://doi.org/10.1093/brain/awaa334",
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"journal": "Brain",
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"last_author": "Jonathan Mill",
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"model_type": "elastic net regression",
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"n_features": 347,
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"notes": "Cortex-specific DNA-methylation chronological-age estimator trained by elastic net on 1,047 post-mortem cortical samples; its 347-CpG weighted score is back-transformed to years.",
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"platform": [
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"Illumina 450K"
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],
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"population": "human, age unspecified",
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"postprocess": "anti_log_linear",
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"predicts": [
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"chronological age"
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],
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"reference_values": true,
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"research_only": null,
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"species": "Homo sapiens",
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"tissue": [
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"brain cortex"
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],
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"training_target": [
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"chronological age"
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],
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"unit": [
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"years"
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],
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"version": "v0.3.0",
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"year": 2020
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}
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corticalclock.pt
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version https://git-lfs.github.com/spec/v1
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oid sha256:7bc6b7569717f2528edaf27d5a0cb7518055a7ac913e71a91a88e9ef932cc111
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size 17317
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