Daily Papers

Metamaterials with functional responses can exhibit varying properties under different conditions (e.g., wave-based responses or deformation-induced property variation). This work addresses the rapid inverse design of such metamaterials to meet target qualitative functional behaviors, a challenge due to its intractability and non-unique solutions. Unlike data-intensive and non-interpretable deep-learning-based methods, we propose the Random-forest-based Interpretable Generative Inverse Design (RIGID), a single-shot inverse design method for fast generation of metamaterial designs with on-demand functional behaviors. RIGID leverages the interpretability of a random forest-based "designrightarrowresponse" forward model, eliminating the need for a more complex "responserightarrowdesign" inverse model. Based on the likelihood of target satisfaction derived from the trained random forest, one can sample a desired number of design solutions using Markov chain Monte Carlo methods. We validate RIGID on acoustic and optical metamaterial design problems, each with fewer than 250 training samples. Compared to the genetic algorithm-based design generation approach, RIGID generates satisfactory solutions that cover a broader range of the design space, allowing for better consideration of additional figures of merit beyond target satisfaction. This work offers a new perspective on solving on-demand inverse design problems, showcasing the potential for incorporating interpretable machine learning into generative design under small data constraints.

Reinforcement learning (RL) has emerged as a powerful framework for improving the reasoning capabilities of large language models (LLMs). However, most existing RL approaches rely on sparse outcome rewards, which fail to credit correct intermediate steps in partially successful solutions. Process reward models (PRMs) offer fine-grained step-level supervision, but their scores are often noisy and difficult to evaluate. As a result, recent PRM benchmarks focus on a more objective capability: detecting the first incorrect step in a reasoning path. However, this evaluation target is misaligned with how PRMs are typically used in RL, where their step-wise scores are treated as raw rewards to maximize. To bridge this gap, we propose Verifiable Prefix Policy Optimization (VPPO), which uses PRMs only to localize the first error during RL. Given an incorrect rollout, VPPO partitions the trajectory into a verified correct prefix and an erroneous suffix based on the first error, rewarding the former while applying targeted penalties only after the detected mistake. This design yields stable, interpretable learning signals and improves credit assignment. Across multiple reasoning benchmarks, VPPO consistently outperforms sparse-reward RL and prior PRM-guided baselines on both Pass@1 and Pass@K.

The rapid growth of ego-centric dashcam footage presents a major challenge for detecting safety-critical events such as collisions and near-collisions, scenarios that are brief, rare, and difficult for generic vision models to capture. While multimodal large language models (MLLMs) demonstrate strong general reasoning ability, they underperform in driving contexts due to domain and temporal misalignment. We introduce VLM-AutoDrive, a modular post-training framework for adapting pretrained Vision-Language Models (VLMs) to high-fidelity anomaly detection. The framework integrates metadata-derived captions, LLM-generated descriptions, visual question answering (VQA) pairs, and chain-of-thought (CoT) reasoning supervision to enable domain-aligned and interpretable learning. Off-the-shelf VLMs such as NVIDIA's Cosmos-Reason1 7B (CR1) exhibit near-zero Collision recall in zero-shot settings; fine-tuning with VLM-AutoDrive improves Collision F1 from 0.00 to 0.69 and overall accuracy from 35.35% to 77.27%. VLM-AutoDrive offers a scalable recipe for adapting general-purpose VLMs to safety-critical, temporally localized perception tasks. Evaluated on real-world Nexar dashcam videos, it achieves substantial gains in Collision and Near-Collision detection while producing interpretable reasoning traces, bridging the gap between perception, causality, and decision reasoning in autonomous driving.

Machine learning methods can be a valuable aid in the scientific process, but they need to face challenging settings where data come from inhomogeneous experimental conditions. Recent meta-learning methods have made significant progress in multi-task learning, but they rely on black-box neural networks, resulting in high computational costs and limited interpretability. Leveraging the structure of the learning problem, we argue that multi-environment generalization can be achieved using a simpler learning model, with an affine structure with respect to the learning task. Crucially, we prove that this architecture can identify the physical parameters of the system, enabling interpreable learning. We demonstrate the competitive generalization performance and the low computational cost of our method by comparing it to state-of-the-art algorithms on physical systems, ranging from toy models to complex, non-analytical systems. The interpretability of our method is illustrated with original applications to physical-parameter-induced adaptation and to adaptive control.

We introduce the Consensus-Bottleneck Asset Pricing Model (CB-APM), a framework that reconciles the predictive power of deep learning with the structural transparency of traditional finance. By embedding aggregate analyst consensus as a structural "bottleneck", the model treats professional beliefs as a sufficient statistic for the market's high-dimensional information set. We document a striking "interpretability-accuracy amplification effect" for annual horizons, the structural constraint acts as an endogenous regularizer that significantly improves out-of-sample R2 over unconstrained benchmarks. Portfolios sorted on CB-APM forecasts exhibit a strong monotonic return gradient, delivering an annualized Sharpe ratio of 1.44 and robust performance across macroeconomic regimes. Furthermore, pricing diagnostics reveal that the learned consensus captures priced variation only partially spanned by canonical factor models, identifying structured risk heterogeneity that standard linear models systematically miss. Our results suggest that anchoring machine intelligence to human-expert belief formation is not merely a tool for transparency, but a catalyst for uncovering new dimensions of belief-driven risk premiums.

PySR is an open-source library for practical symbolic regression, a type of machine learning which aims to discover human-interpretable symbolic models. PySR was developed to democratize and popularize symbolic regression for the sciences, and is built on a high-performance distributed back-end, a flexible search algorithm, and interfaces with several deep learning packages. PySR's internal search algorithm is a multi-population evolutionary algorithm, which consists of a unique evolve-simplify-optimize loop, designed for optimization of unknown scalar constants in newly-discovered empirical expressions. PySR's backend is the extremely optimized Julia library SymbolicRegression.jl, which can be used directly from Julia. It is capable of fusing user-defined operators into SIMD kernels at runtime, performing automatic differentiation, and distributing populations of expressions to thousands of cores across a cluster. In describing this software, we also introduce a new benchmark, "EmpiricalBench," to quantify the applicability of symbolic regression algorithms in science. This benchmark measures recovery of historical empirical equations from original and synthetic datasets.

Interpretability in machine learning (ML) is crucial for high stakes decisions and troubleshooting. In this work, we provide fundamental principles for interpretable ML, and dispel common misunderstandings that dilute the importance of this crucial topic. We also identify 10 technical challenge areas in interpretable machine learning and provide history and background on each problem. Some of these problems are classically important, and some are recent problems that have arisen in the last few years. These problems are: (1) Optimizing sparse logical models such as decision trees; (2) Optimization of scoring systems; (3) Placing constraints into generalized additive models to encourage sparsity and better interpretability; (4) Modern case-based reasoning, including neural networks and matching for causal inference; (5) Complete supervised disentanglement of neural networks; (6) Complete or even partial unsupervised disentanglement of neural networks; (7) Dimensionality reduction for data visualization; (8) Machine learning models that can incorporate physics and other generative or causal constraints; (9) Characterization of the "Rashomon set" of good models; and (10) Interpretable reinforcement learning. This survey is suitable as a starting point for statisticians and computer scientists interested in working in interpretable machine learning.

Style representation learning builds content-independent representations of author style in text. Stylometry, the analysis of style in text, is often performed by expert forensic linguists and no large dataset of stylometric annotations exists for training. Current style representation learning uses neural methods to disentangle style from content to create style vectors, however, these approaches result in uninterpretable representations, complicating their usage in downstream applications like authorship attribution where auditing and explainability is critical. In this work, we use prompting to perform stylometry on a large number of texts to create a synthetic dataset and train human-interpretable style representations we call LISA embeddings. We release our synthetic stylometry dataset and our interpretable style models as resources.

Pretrained generative models have opened new frontiers in brain decoding by enabling the synthesis of realistic texts and images from non-invasive brain recordings. However, the reliability of such outputs remains questionable--whether they truly reflect semantic activation in the brain, or are merely hallucinated by the powerful generative models. In this paper, we focus on EEG-to-text decoding and address its hallucination issue through the lens of posterior collapse. Acknowledging the underlying mismatch in information capacity between EEG and text, we reframe the decoding task as semantic summarization of core meanings rather than previously verbatim reconstruction of stimulus texts. To this end, we propose the Generative Language Inspection Model (GLIM), which emphasizes learning informative and interpretable EEG representations to improve semantic grounding under heterogeneous and small-scale data conditions. Experiments on the public ZuCo dataset demonstrate that GLIM consistently generates fluent, EEG-grounded sentences without teacher forcing. Moreover, it supports more robust evaluation beyond text similarity, through EEG-text retrieval and zero-shot semantic classification across sentiment categories, relation types, and corpus topics. Together, our architecture and evaluation protocols lay the foundation for reliable and scalable benchmarking in generative brain decoding.

Deep learning-based electrocardiogram (ECG) classification has shown impressive performance but clinical adoption has been slowed by the lack of transparent and faithful explanations. Post hoc methods such as saliency maps may fail to reflect a model's true decision process. Prototype-based reasoning offers a more transparent alternative by grounding decisions in similarity to learned representations of real ECG segments, enabling faithful, case-based explanations. We introduce ProtoECGNet, a prototype-based deep learning model for interpretable, multi-label ECG classification. ProtoECGNet employs a structured, multi-branch architecture that reflects clinical interpretation workflows: it integrates a 1D CNN with global prototypes for rhythm classification, a 2D CNN with time-localized prototypes for morphology-based reasoning, and a 2D CNN with global prototypes for diffuse abnormalities. Each branch is trained with a prototype loss designed for multi-label learning, combining clustering, separation, diversity, and a novel contrastive loss that encourages appropriate separation between prototypes of unrelated classes while allowing clustering for frequently co-occurring diagnoses. We evaluate ProtoECGNet on all 71 diagnostic labels from the PTB-XL dataset, demonstrating competitive performance relative to state-of-the-art black-box models while providing structured, case-based explanations. To assess prototype quality, we conduct a structured clinician review of the final model's projected prototypes, finding that they are rated as representative and clear. ProtoECGNet shows that prototype learning can be effectively scaled to complex, multi-label time-series classification, offering a practical path toward transparent and trustworthy deep learning models for clinical decision support.

Legal case retrieval for sourcing similar cases is critical in upholding judicial fairness. Different from general web search, legal case retrieval involves processing lengthy, complex, and highly specialized legal documents. Existing methods in this domain often overlook the incorporation of legal expert knowledge, which is crucial for accurately understanding and modeling legal cases, leading to unsatisfactory retrieval performance. This paper introduces KELLER, a legal knowledge-guided case reformulation approach based on large language models (LLMs) for effective and interpretable legal case retrieval. By incorporating professional legal knowledge about crimes and law articles, we enable large language models to accurately reformulate the original legal case into concise sub-facts of crimes, which contain the essential information of the case. Extensive experiments on two legal case retrieval benchmarks demonstrate superior retrieval performance and robustness on complex legal case queries of KELLER over existing methods.

While large language models (LLMs) now excel at code generation, a key aspect of software development is the art of refactoring: consolidating code into libraries of reusable and readable programs. In this paper, we introduce LILO, a neurosymbolic framework that iteratively synthesizes, compresses, and documents code to build libraries tailored to particular problem domains. LILO combines LLM-guided program synthesis with recent algorithmic advances in automated refactoring from Stitch: a symbolic compression system that efficiently identifies optimal lambda abstractions across large code corpora. To make these abstractions interpretable, we introduce an auto-documentation (AutoDoc) procedure that infers natural language names and docstrings based on contextual examples of usage. In addition to improving human readability, we find that AutoDoc boosts performance by helping LILO's synthesizer to interpret and deploy learned abstractions. We evaluate LILO on three inductive program synthesis benchmarks for string editing, scene reasoning, and graphics composition. Compared to existing neural and symbolic methods - including the state-of-the-art library learning algorithm DreamCoder - LILO solves more complex tasks and learns richer libraries that are grounded in linguistic knowledge.

Symbolic regression (SR) aims to discover closed-form mathematical expressions that accurately describe data, offering interpretability and analytical insight beyond standard black-box models. Existing SR methods often rely on population-based search or autoregressive modeling, which struggle with scalability and symbolic consistency. We introduce LIES (Logarithm, Identity, Exponential, Sine), a fixed neural network architecture with interpretable primitive activations that are optimized to model symbolic expressions. We develop a framework to extract compact formulae from LIES networks by training with an appropriate oversampling strategy and a tailored loss function to promote sparsity and to prevent gradient instability. After training, it applies additional pruning strategies to further simplify the learned expressions into compact formulae. Our experiments on SR benchmarks show that the LIES framework consistently produces sparse and accurate symbolic formulae outperforming all baselines. We also demonstrate the importance of each design component through ablation studies.

Deep learning models are susceptible to adversarial samples in white and black-box environments. Although previous studies have shown high attack success rates, coupling DNN models with interpretation models could offer a sense of security when a human expert is involved, who can identify whether a given sample is benign or malicious. However, in white-box environments, interpretable deep learning systems (IDLSes) have been shown to be vulnerable to malicious manipulations. In black-box settings, as access to the components of IDLSes is limited, it becomes more challenging for the adversary to fool the system. In this work, we propose a Query-efficient Score-based black-box attack against IDLSes, QuScore, which requires no knowledge of the target model and its coupled interpretation model. QuScore is based on transfer-based and score-based methods by employing an effective microbial genetic algorithm. Our method is designed to reduce the number of queries necessary to carry out successful attacks, resulting in a more efficient process. By continuously refining the adversarial samples created based on feedback scores from the IDLS, our approach effectively navigates the search space to identify perturbations that can fool the system. We evaluate the attack's effectiveness on four CNN models (Inception, ResNet, VGG, DenseNet) and two interpretation models (CAM, Grad), using both ImageNet and CIFAR datasets. Our results show that the proposed approach is query-efficient with a high attack success rate that can reach between 95% and 100% and transferability with an average success rate of 69% in the ImageNet and CIFAR datasets. Our attack method generates adversarial examples with attribution maps that resemble benign samples. We have also demonstrated that our attack is resilient against various preprocessing defense techniques and can easily be transferred to different DNN models.

We propose a novel high-performance and interpretable canonical deep tabular data learning architecture, TabNet. TabNet uses sequential attention to choose which features to reason from at each decision step, enabling interpretability and more efficient learning as the learning capacity is used for the most salient features. We demonstrate that TabNet outperforms other neural network and decision tree variants on a wide range of non-performance-saturated tabular datasets and yields interpretable feature attributions plus insights into the global model behavior. Finally, for the first time to our knowledge, we demonstrate self-supervised learning for tabular data, significantly improving performance with unsupervised representation learning when unlabeled data is abundant.

Continuous control tasks often involve high-dimensional, dynamic, and non-linear environments. State-of-the-art performance in these tasks is achieved through complex closed-box policies that are effective, but suffer from an inherent opacity. Interpretable policies, while generally underperforming compared to their closed-box counterparts, advantageously facilitate transparent decision-making within automated systems. Hence, their usage is often essential for diagnosing and mitigating errors, supporting ethical and legal accountability, and fostering trust among stakeholders. In this paper, we propose SMOSE, a novel method to train sparsely activated interpretable controllers, based on a top-1 Mixture-of-Experts architecture. SMOSE combines a set of interpretable decisionmakers, trained to be experts in different basic skills, and an interpretable router that assigns tasks among the experts. The training is carried out via state-of-the-art Reinforcement Learning algorithms, exploiting load-balancing techniques to ensure fair expert usage. We then distill decision trees from the weights of the router, significantly improving the ease of interpretation. We evaluate SMOSE on six benchmark environments from MuJoCo: our method outperforms recent interpretable baselines and narrows the gap with noninterpretable state-of-the-art algorithms

As machine learning systems become ubiquitous, there has been a surge of interest in interpretable machine learning: systems that provide explanation for their outputs. These explanations are often used to qualitatively assess other criteria such as safety or non-discrimination. However, despite the interest in interpretability, there is very little consensus on what interpretable machine learning is and how it should be measured. In this position paper, we first define interpretability and describe when interpretability is needed (and when it is not). Next, we suggest a taxonomy for rigorous evaluation and expose open questions towards a more rigorous science of interpretable machine learning.

Human feedback can alter language models in unpredictable and undesirable ways, as practitioners lack a clear understanding of what feedback data encodes. While prior work studies preferences over certain attributes (e.g., length or sycophancy), automatically extracting relevant features without pre-specifying hypotheses remains challenging. We introduce What's In My Human Feedback? (WIMHF), a method to explain feedback data using sparse autoencoders. WIMHF characterizes both (1) the preferences a dataset is capable of measuring and (2) the preferences that the annotators actually express. Across 7 datasets, WIMHF identifies a small number of human-interpretable features that account for the majority of the preference prediction signal achieved by black-box models. These features reveal a wide diversity in what humans prefer, and the role of dataset-level context: for example, users on Reddit prefer informality and jokes, while annotators in HH-RLHF and PRISM disprefer them. WIMHF also surfaces potentially unsafe preferences, such as that LMArena users tend to vote against refusals, often in favor of toxic content. The learned features enable effective data curation: re-labeling the harmful examples in Arena yields large safety gains (+37%) with no cost to general performance. They also allow fine-grained personalization: on the Community Alignment dataset, we learn annotator-specific weights over subjective features that improve preference prediction. WIMHF provides a human-centered analysis method for practitioners to better understand and use preference data.

Learning transparent, interpretable controllers with offline data in decision-making systems is an essential area of research due to its potential to reduce the risk of applications in real-world systems. However, in responsibility-sensitive settings such as healthcare, decision accountability is of paramount importance, yet has not been adequately addressed by the literature. This paper introduces the Accountable Offline Controller (AOC) that employs the offline dataset as the Decision Corpus and performs accountable control based on a tailored selection of examples, referred to as the Corpus Subset. ABC operates effectively in low-data scenarios, can be extended to the strictly offline imitation setting, and displays qualities of both conservation and adaptability. We assess ABC's performance in both simulated and real-world healthcare scenarios, emphasizing its capability to manage offline control tasks with high levels of performance while maintaining accountability. Keywords: Interpretable Reinforcement Learning, Explainable Reinforcement Learning, Reinforcement Learning Transparency, Offline Reinforcement Learning, Batched Control.

Integrating heterogeneous biomedical data including imaging, omics, and clinical records supports accurate diagnosis and personalised care. Graph-based models fuse such non-Euclidean data by capturing spatial and relational structure, yet clinical uptake requires regulator-ready interpretability. We present the first technical survey of interpretable graph based models for multimodal biomedical data, covering 26 studies published between Jan 2019 and Sep 2024. Most target disease classification, notably cancer and rely on static graphs from simple similarity measures, while graph-native explainers are rare; post-hoc methods adapted from non-graph domains such as gradient saliency, and SHAP predominate. We group existing approaches into four interpretability families, outline trends such as graph-in-graph hierarchies, knowledge-graph edges, and dynamic topology learning, and perform a practical benchmark. Using an Alzheimer disease cohort, we compare Sensitivity Analysis, Gradient Saliency, SHAP and Graph Masking. SHAP and Sensitivity Analysis recover the broadest set of known AD pathways and Gene-Ontology terms, whereas Gradient Saliency and Graph Masking surface complementary metabolic and transport signatures. Permutation tests show all four beat random gene sets, but with distinct trade-offs: SHAP and Graph Masking offer deeper biology at higher compute cost, while Gradient Saliency and Sensitivity Analysis are quicker though coarser. We also provide a step-by-step flowchart covering graph construction, explainer choice and resource budgeting to help researchers balance transparency and performance. This review synthesises the state of interpretable graph learning for multimodal medicine, benchmarks leading techniques, and charts future directions, from advanced XAI tools to under-studied diseases, serving as a concise reference for method developers and translational scientists.

What latent features are encoded in language model (LM) representations? Recent work on training sparse autoencoders (SAEs) to disentangle interpretable features in LM representations has shown significant promise. However, evaluating the quality of these SAEs is difficult because we lack a ground-truth collection of interpretable features that we expect good SAEs to recover. We thus propose to measure progress in interpretable dictionary learning by working in the setting of LMs trained on chess and Othello transcripts. These settings carry natural collections of interpretable features -- for example, "there is a knight on F3" -- which we leverage into supervised metrics for SAE quality. To guide progress in interpretable dictionary learning, we introduce a new SAE training technique, p-annealing, which improves performance on prior unsupervised metrics as well as our new metrics.

Sleep quality is influenced by a complex interplay of behavioral, environmental, and psychosocial factors, yet most computational studies focus mainly on predictive risk identification rather than actionable intervention design. Although machine learning models can accurately predict subjective sleep outcomes, they rarely translate predictive insights into practical intervention strategies. To address this gap, we propose a personalized predictive-prescriptive framework that integrates interpretable machine learning with mixed-integer optimization. A supervised classifier trained on survey data predicts sleep quality, while SHAP-based feature attribution quantifies the influence of modifiable factors. These importance measures are incorporated into a mixed-integer optimization model that identifies minimal and feasible behavioral adjustments, while modelling resistance to change through a penalty mechanism. The framework achieves strong predictive performance, with a test F1-score of 0.9544 and an accuracy of 0.9366. Sensitivity and Pareto analyses reveal a clear trade-off between expected improvement and intervention intensity, with diminishing returns as additional changes are introduced. At the individual level, the model generates concise recommendations, often suggesting one or two high-impact behavioral adjustments and sometimes recommending no change when expected gains are minimal. By integrating prediction, explanation, and constrained optimization, this framework demonstrates how data-driven insights can be translated into structured and personalized decision support for sleep improvement.

Rule extraction is a central problem in interpretable machine learning because it seeks to convert opaque predictive behavior into human-readable symbolic structure. This paper presents Chat Incremental Pattern Constructor (ChatIPC), a lightweight incremental symbolic learning system that extracts ordered token-transition rules from text, enriches them with definition based expansion, and constructs responses by similarity-guided candidate selection. The system may be viewed as a rule extractor operating over a token graph rather than a conventional classifier. I formalize the knowledge base, definition expansion, candidate scoring, repetition control, and response construction mechanisms used in ChatIPC. I further situate the method within the literature on rule extraction, decision tree induction, association rules, and interpretable sequence modeling. The paper emphasizes mathematical formulation and algorithmic clarity, and it provides pseudocode for the learning and construction pipeline.

Discovering new materials is essential to solve challenges in climate change, sustainability and healthcare. A typical task in materials discovery is to search for a material in a database which maximises the value of a function. That function is often expensive to evaluate, and can rely upon a simulation or an experiment. Here, we introduce SyMDis, a sample efficient optimisation method based on symbolic learning, that discovers near-optimal materials in a large database. SyMDis performs comparably to a state-of-the-art optimiser, whilst learning interpretable rules to aid physical and chemical verification. Furthermore, the rules learned by SyMDis generalise to unseen datasets and return high performing candidates in a zero-shot evaluation, which is difficult to achieve with other approaches.

Recent research in mechanistic interpretability has attempted to reverse-engineer Transformer models by carefully inspecting network weights and activations. However, these approaches require considerable manual effort and still fall short of providing complete, faithful descriptions of the underlying algorithms. In this work, we introduce a procedure for training Transformers that are mechanistically interpretable by design. We build on RASP [Weiss et al., 2021], a programming language that can be compiled into Transformer weights. Instead of compiling human-written programs into Transformers, we design a modified Transformer that can be trained using gradient-based optimization and then automatically converted into a discrete, human-readable program. We refer to these models as Transformer Programs. To validate our approach, we learn Transformer Programs for a variety of problems, including an in-context learning task, a suite of algorithmic problems (e.g. sorting, recognizing Dyck languages), and NLP tasks including named entity recognition and text classification. The Transformer Programs can automatically find reasonable solutions, performing on par with standard Transformers of comparable size; and, more importantly, they are easy to interpret. To demonstrate these advantages, we convert Transformers into Python programs and use off-the-shelf code analysis tools to debug model errors and identify the "circuits" used to solve different sub-problems. We hope that Transformer Programs open a new path toward the goal of intrinsically interpretable machine learning.

Prototype-based methods use interpretable representations to address the black-box nature of deep learning models, in contrast to post-hoc explanation methods that only approximate such models. We propose the Neural Prototype Tree (ProtoTree), an intrinsically interpretable deep learning method for fine-grained image recognition. ProtoTree combines prototype learning with decision trees, and thus results in a globally interpretable model by design. Additionally, ProtoTree can locally explain a single prediction by outlining a decision path through the tree. Each node in our binary tree contains a trainable prototypical part. The presence or absence of this learned prototype in an image determines the routing through a node. Decision making is therefore similar to human reasoning: Does the bird have a red throat? And an elongated beak? Then it's a hummingbird! We tune the accuracy-interpretability trade-off using ensemble methods, pruning and binarizing. We apply pruning without sacrificing accuracy, resulting in a small tree with only 8 learned prototypes along a path to classify a bird from 200 species. An ensemble of 5 ProtoTrees achieves competitive accuracy on the CUB-200- 2011 and Stanford Cars data sets. Code is available at https://github.com/M-Nauta/ProtoTree

Neural Ordinary Differential Equations (NODEs) often struggle to adapt to new dynamic behaviors caused by parameter changes in the underlying physical system, even when these dynamics are similar to previously observed behaviors. This problem becomes more challenging when the changing parameters are unobserved, meaning their value or influence cannot be directly measured when collecting data. To address this issue, we introduce Neural Context Flow (NCF), a robust and interpretable Meta-Learning framework that includes uncertainty estimation. NCF uses Taylor expansion to enable contextual self-modulation, allowing context vectors to influence dynamics from other domains while also modulating themselves. After establishing theoretical guarantees, we empirically test NCF and compare it to related adaptation methods. Our results show that NCF achieves state-of-the-art Out-of-Distribution performance on 5 out of 6 linear and non-linear benchmark problems. Through extensive experiments, we explore the flexible model architecture of NCF and the encoded representations within the learned context vectors. Our findings highlight the potential implications of NCF for foundational models in the physical sciences, offering a promising approach to improving the adaptability and generalization of NODEs in various scientific applications. Our code is openly available at https://github.com/ddrous/ncflow.

Intelligent tutoring systems optimize the selection and timing of learning materials to enhance understanding and long-term retention. This requires estimates of both the learner's progress (''knowledge tracing''; KT), and the prerequisite structure of the learning domain (''knowledge mapping''). While recent deep learning models achieve high KT accuracy, they do so at the expense of the interpretability of psychologically-inspired models. In this work, we present a solution to this trade-off. PSI-KT is a hierarchical generative approach that explicitly models how both individual cognitive traits and the prerequisite structure of knowledge influence learning dynamics, thus achieving interpretability by design. Moreover, by using scalable Bayesian inference, PSI-KT targets the real-world need for efficient personalization even with a growing body of learners and learning histories. Evaluated on three datasets from online learning platforms, PSI-KT achieves superior multi-step predictive accuracy and scalable inference in continual-learning settings, all while providing interpretable representations of learner-specific traits and the prerequisite structure of knowledge that causally supports learning. In sum, predictive, scalable and interpretable knowledge tracing with solid knowledge mapping lays a key foundation for effective personalized learning to make education accessible to a broad, global audience.

In the context of electroencephalogram (EEG)-based driver drowsiness recognition, it is still challenging to design a calibration-free system, since EEG signals vary significantly among different subjects and recording sessions. Many efforts have been made to use deep learning methods for mental state recognition from EEG signals. However, existing work mostly treats deep learning models as black-box classifiers, while what have been learned by the models and to which extent they are affected by the noise in EEG data are still underexplored. In this paper, we develop a novel convolutional neural network combined with an interpretation technique that allows sample-wise analysis of important features for classification. The network has a compact structure and takes advantage of separable convolutions to process the EEG signals in a spatial-temporal sequence. Results show that the model achieves an average accuracy of 78.35% on 11 subjects for leave-one-out cross-subject drowsiness recognition, which is higher than the conventional baseline methods of 53.40%-72.68% and state-of-the-art deep learning methods of 71.75%-75.19%. Interpretation results indicate the model has learned to recognize biologically meaningful features from EEG signals, e.g., Alpha spindles, as strong indicators of drowsiness across different subjects. In addition, we also explore reasons behind some wrongly classified samples with the interpretation technique and discuss potential ways to improve the recognition accuracy. Our work illustrates a promising direction on using interpretable deep learning models to discover meaningful patterns related to different mental states from complex EEG signals.

Genetic pathways usually encode molecular mechanisms that can inform targeted interventions. It is often challenging for existing machine learning approaches to jointly model genetic pathways (higher-order features) and variants (atomic features), and present to clinicians interpretable models. In order to build more accurate and better interpretable machine learning models for genetic medicine, we introduce Pathway Augmented Nonnegative Tensor factorization for HighER-order feature learning (PANTHER). PANTHER selects informative genetic pathways that directly encode molecular mechanisms. We apply genetically motivated constrained tensor factorization to group pathways in a way that reflects molecular mechanism interactions. We then train a softmax classifier for disease types using the identified pathway groups. We evaluated PANTHER against multiple state-of-the-art constrained tensor/matrix factorization models, as well as group guided and Bayesian hierarchical models. PANTHER outperforms all state-of-the-art comparison models significantly (p<0.05). Our experiments on large scale Next Generation Sequencing (NGS) and whole-genome genotyping datasets also demonstrated wide applicability of PANTHER. We performed feature analysis in predicting disease types, which suggested insights and benefits of the identified pathway groups.

Understanding the physical world requires perceptual models grounded in physical laws rather than mere statistical correlations. However, existing multimodal learning frameworks, focused on vision and language, lack physical consistency and overlook the intrinsic causal relationships among an object's geometry, material, vibration modes, and the sounds it produces. We introduce VibraVerse, a large-scale geometry-acoustics alignment dataset that explicitly bridges the causal chain from 3D geometry -> physical attributes -> modal parameters -> acoustic signals. Each 3D model has explicit physical properties (density, Young's modulus, Poisson's ratio) and volumetric geometry, from which modal eigenfrequencies and eigenvectors are computed for impact sound synthesis under controlled excitations. To establish this coherence, we introduce CLASP, a contrastive learning framework for cross-modal alignment that preserves the causal correspondence between an object's physical structure and its acoustic response. This framework enforces physically consistent alignment across modalities, ensuring that every sample is coherent, traceable to the governing equations, and embedded within a unified representation space spanning shape, image, and sound. Built upon VibraVerse, we define a suite of benchmark tasks for geometry-to-sound prediction, sound-guided shape reconstruction, and cross-modal representation learning. Extensive validations on these tasks demonstrate that models trained on VibraVerse exhibit superior accuracy, interpretability, and generalization across modalities. These results establish VibraVerse as a benchmark for physically consistent and causally interpretable multimodal learning, providing a foundation for sound-guided embodied perception and a deeper understanding of the physical world. The dataset will be open-sourced.

Contemporary machine learning paradigm excels in statistical data analysis, solving problems that classical AI couldn't. However, it faces key limitations, such as a lack of integration with planning, incomprehensible internal structure, and inability to learn continually. We present the initial design for an AI system, Agential AI (AAI), in principle operating independently or on top of statistical methods, designed to overcome these issues. AAI's core is a learning method that models temporal dynamics with guarantees of completeness, minimality, and continual learning, using component-level variation and selection to learn the structure of the environment. It integrates this with a behavior algorithm that plans on a learned model and encapsulates high-level behavior patterns. Preliminary experiments on a simple environment show AAI's effectiveness and potential.

This paper systematically reviews the research progress and application prospects of machine learning technologies in the field of polymer materials. Currently, machine learning methods are developing rapidly in polymer material research; although they have significantly accelerated material prediction and design, their complexity has also caused difficulties in understanding and application for researchers in traditional fields. In response to the above issues, this paper first analyzes the inherent challenges in the research and development of polymer materials, including structural complexity and the limitations of traditional trial-and-error methods. To address these problems, it focuses on introducing key basic technologies such as molecular descriptors and feature representation, data standardization and cleaning, and records a number of high-quality polymer databases. Subsequently, it elaborates on the key role of machine learning in polymer property prediction and material design, covering the specific applications of algorithms such as traditional machine learning, deep learning, and transfer learning; further, it deeply expounds on data-driven design strategies, such as reverse design, high-throughput virtual screening, and multi-objective optimization. The paper also systematically introduces the complete process of constructing high-reliability machine learning models and summarizes effective experimental verification, model evaluation, and optimization methods. Finally, it summarizes the current technical challenges in research, such as data quality and model generalization ability, and looks forward to future development trends including multi-scale modeling, physics-informed machine learning, standardized data sharing, and interpretable machine learning.

Interpretable machine learning has exploded as an area of interest over the last decade, sparked by the rise of increasingly large datasets and deep neural networks. Simultaneously, large language models (LLMs) have demonstrated remarkable capabilities across a wide array of tasks, offering a chance to rethink opportunities in interpretable machine learning. Notably, the capability to explain in natural language allows LLMs to expand the scale and complexity of patterns that can be given to a human. However, these new capabilities raise new challenges, such as hallucinated explanations and immense computational costs. In this position paper, we start by reviewing existing methods to evaluate the emerging field of LLM interpretation (both interpreting LLMs and using LLMs for explanation). We contend that, despite their limitations, LLMs hold the opportunity to redefine interpretability with a more ambitious scope across many applications, including in auditing LLMs themselves. We highlight two emerging research priorities for LLM interpretation: using LLMs to directly analyze new datasets and to generate interactive explanations.

The early prediction of battery life (EPBL) is vital for enhancing the efficiency and extending the lifespan of lithium batteries. Traditional models with fixed architectures often encounter underfitting or overfitting issues due to the diverse data distributions in different EPBL tasks. An interpretable deep learning model of flexible parallel neural network (FPNN) is proposed, which includes an InceptionBlock, a 3D convolutional neural network (CNN), a 2D CNN, and a dual-stream network. The proposed model effectively extracts electrochemical features from video-like formatted data using the 3D CNN and achieves advanced multi-scale feature abstraction through the InceptionBlock. The FPNN can adaptively adjust the number of InceptionBlocks to flexibly handle tasks of varying complexity in EPBL. The test on the MIT dataset shows that the FPNN model achieves outstanding predictive accuracy in EPBL tasks, with MAPEs of 2.47%, 1.29%, 1.08%, and 0.88% when the input cyclic data volumes are 10, 20, 30, and 40, respectively. The interpretability of the FPNN is mainly reflected in its flexible unit structure and parameter selection: its diverse branching structure enables the model to capture features at different scales, thus allowing the machine to learn informative features. The approach presented herein provides an accurate, adaptable, and comprehensible solution for early life prediction of lithium batteries, opening new possibilities in the field of battery health monitoring.

AI-agents help developers in different coding tasks, such as developing new features, fixing bugs, and reviewing code. Developers can write a Github issue and assign it to an AI-agent like Copilot for implementation. Based on the issue and its related discussion, the AI-agent performs a plan for the implementation, and executes it. However, the performance of AI-agents and LLMs heavily depends on the input they receive. For instance, a GitHub issue that is unclear or not well scoped might not lead to a successful implementation that will eventually be merged. GitHub Copilot provides a set of best practice recommendations that are limited and high-level. In this paper, we build a set of 32 detailed criteria that we leverage to measure the quality of GitHub issues to make them suitable for AI-agents. We compare the GitHub issues that lead to a merged pull request versus closed pull request. Then, we build an interpretable machine learning model to predict the likelihood of a GitHub issue resulting in a merged pull request. We observe that pull requests that end up being merged are those originating from issues that are shorter, well scoped, with clear guidance and hints about the relevant artifacts for an issue, and with guidance on how to perform the implementation. Issues with external references including configuration, context setup, dependencies or external APIs are associated with lower merge rates. We built an interpretable machine learning model to help users identify how to improve a GitHub issue to increase the chances of the issue resulting in a merged pull request by Copilot. Our model has a median AUC of 72\%. Our results shed light on quality metrics relevant for writing GitHub issues and motivate future studies further investigate the writing of GitHub issues as a first-class software engineering activity in the era of AI-teammates.

Recent strides in interpretable machine learning (ML) research reveal that models exploit undesirable patterns in the data to make predictions, which potentially causes harms in deployment. However, it is unclear how we can fix these models. We present our ongoing work, GAM Changer, an open-source interactive system to help data scientists and domain experts easily and responsibly edit their Generalized Additive Models (GAMs). With novel visualization techniques, our tool puts interpretability into action -- empowering human users to analyze, validate, and align model behaviors with their knowledge and values. Built using modern web technologies, our tool runs locally in users' computational notebooks or web browsers without requiring extra compute resources, lowering the barrier to creating more responsible ML models. GAM Changer is available at https://interpret.ml/gam-changer.

In Autonomous Driving (AD) transparency and safety are paramount, as mistakes are costly. However, neural networks used in AD systems are generally considered black boxes. As a countermeasure, we have methods of explainable AI (XAI), such as feature relevance estimation and dimensionality reduction. Coarse graining techniques can also help reduce dimensionality and find interpretable global patterns. A specific coarse graining method is Renormalization Groups from statistical physics. It has previously been applied to Restricted Boltzmann Machines (RBMs) to interpret unsupervised learning. We refine this technique by building a transparent backbone model for convolutional variational autoencoders (VAE) that allows mapping latent values to input features and has performance comparable to trained black box VAEs. Moreover, we propose a custom feature map visualization technique to analyze the internal convolutional layers in the VAE to explain internal causes of poor reconstruction that may lead to dangerous traffic scenarios in AD applications. In a second key contribution, we propose explanation and evaluation techniques for the internal dynamics and feature relevance of prediction networks. We test a long short-term memory (LSTM) network in the computer vision domain to evaluate the predictability and in future applications potentially safety of prediction models. We showcase our methods by analyzing a VAE-LSTM world model that predicts pedestrian perception in an urban traffic situation.

Discovering causal structures with latent variables from observational data is a fundamental challenge in causal discovery. Existing methods often rely on constraint-based, iterative discrete searches, limiting their scalability to large numbers of variables. Moreover, these methods frequently assume linearity or invertibility, restricting their applicability to real-world scenarios. We present new theoretical results on the identifiability of nonlinear latent hierarchical causal models, relaxing previous assumptions in literature about the deterministic nature of latent variables and exogenous noise. Building on these insights, we develop a novel differentiable causal discovery algorithm that efficiently estimates the structure of such models. To the best of our knowledge, this is the first work to propose a differentiable causal discovery method for nonlinear latent hierarchical models. Our approach outperforms existing methods in both accuracy and scalability. We demonstrate its practical utility by learning interpretable hierarchical latent structures from high-dimensional image data and demonstrate its effectiveness on downstream tasks.

The growing popularity of wearable sensors has generated large quantities of temporal physiological and activity data. Ability to analyze this data offers new opportunities for real-time health monitoring and forecasting. However, temporal physiological data presents many analytic challenges: the data is noisy, contains many missing values, and each series has a different length. Most methods proposed for time series analysis and classification do not handle datasets with these characteristics nor do they offer interpretability and explainability, a critical requirement in the health domain. We propose an unsupervised method for learning representations of time series based on common patterns identified within them. The patterns are, interpretable, variable in length, and extracted using Byte Pair Encoding compression technique. In this way the method can capture both long-term and short-term dependencies present in the data. We show that this method applies to both univariate and multivariate time series and beats state-of-the-art approaches on a real world dataset collected from wearable sensors.

Despite the growing popularity of explainable and interpretable machine learning, there is still surprisingly limited work on inherently interpretable clustering methods. Recently, there has been a surge of interest in explaining the classic k-means algorithm, leading to efficient algorithms that approximate k-means clusters using axis-aligned decision trees. However, interpretable variants of k-means have limited applicability in practice, where more flexible clustering methods are often needed to obtain useful partitions of the data. In this work, we investigate interpretable kernel clustering, and propose algorithms that construct decision trees to approximate the partitions induced by kernel k-means, a nonlinear extension of k-means. We further build on previous work on explainable k-means and demonstrate how a suitable choice of features allows preserving interpretability without sacrificing approximation guarantees on the interpretable model.

Symbolic regression (SR) is an area of interpretable machine learning that aims to identify mathematical expressions, often composed of simple functions, that best fit in a given set of covariates X and response y. In recent years, deep symbolic regression (DSR) has emerged as a popular method in the field by leveraging deep reinforcement learning to solve the complicated combinatorial search problem. In this work, we propose an alternative framework (GFN-SR) to approach SR with deep learning. We model the construction of an expression tree as traversing through a directed acyclic graph (DAG) so that GFlowNet can learn a stochastic policy to generate such trees sequentially. Enhanced with an adaptive reward baseline, our method is capable of generating a diverse set of best-fitting expressions. Notably, we observe that GFN-SR outperforms other SR algorithms in noisy data regimes, owing to its ability to learn a distribution of rewards over a space of candidate solutions.

Explainable Deep Learning has gained significant attention in the field of artificial intelligence (AI), particularly in domains such as medical imaging, where accurate and interpretable machine learning models are crucial for effective diagnosis and treatment planning. Grad-CAM is a baseline that highlights the most critical regions of an image used in a deep learning model's decision-making process, increasing interpretability and trust in the results. It is applied in many computer vision (CV) tasks such as classification and explanation. This study explores the principles of Explainable Deep Learning and its relevance to medical imaging, discusses various explainability techniques and their limitations, and examines medical imaging applications of Grad-CAM. The findings highlight the potential of Explainable Deep Learning and Grad-CAM in improving the accuracy and interpretability of deep learning models in medical imaging. The code is available in (will be available).

Sparse linear models are one of several core tools for interpretable machine learning, a field of emerging importance as predictive models permeate decision-making in many domains. Unfortunately, sparse linear models are far less flexible as functions of their input features than black-box models like deep neural networks. With this capability gap in mind, we study a not-uncommon situation where the input features dichotomize into two groups: explanatory features, which are candidates for inclusion as variables in an interpretable model, and contextual features, which select from the candidate variables and determine their effects. This dichotomy leads us to the contextual lasso, a new statistical estimator that fits a sparse linear model to the explanatory features such that the sparsity pattern and coefficients vary as a function of the contextual features. The fitting process learns this function nonparametrically via a deep neural network. To attain sparse coefficients, we train the network with a novel lasso regularizer in the form of a projection layer that maps the network's output onto the space of ell_1-constrained linear models. An extensive suite of experiments on real and synthetic data suggests that the learned models, which remain highly transparent, can be sparser than the regular lasso without sacrificing the predictive power of a standard deep neural network.

We introduce the variational graph auto-encoder (VGAE), a framework for unsupervised learning on graph-structured data based on the variational auto-encoder (VAE). This model makes use of latent variables and is capable of learning interpretable latent representations for undirected graphs. We demonstrate this model using a graph convolutional network (GCN) encoder and a simple inner product decoder. Our model achieves competitive results on a link prediction task in citation networks. In contrast to most existing models for unsupervised learning on graph-structured data and link prediction, our model can naturally incorporate node features, which significantly improves predictive performance on a number of benchmark datasets.

Vector Symbolic Architectures (VSAs) have emerged as a novel framework for enabling interpretable machine learning algorithms equipped with the ability to reason and explain their decision processes. The basic idea is to represent discrete information through high dimensional random vectors. Complex data structures can be built up with operations over vectors such as the "binding" operation involving element-wise vector multiplication, which associates data together. The reverse task of decomposing the associated elements is a combinatorially hard task, with an exponentially large search space. The main algorithm for performing this search is the resonator network, inspired by Hopfield network-based memory search operations. In this work, we introduce a new variant of the resonator network, based on self-attention based update rules in the iterative search problem. This update rule, based on the Hopfield network with log-sum-exp energy function and norm-bounded states, is shown to substantially improve the performance and rate of convergence. As a result, our algorithm enables a larger capacity for associative memory, enabling applications in many tasks like perception based pattern recognition, scene decomposition, and object reasoning. We substantiate our algorithm with a thorough evaluation and comparisons to baselines.

The field of Explainable Artificial Intelligence (XAI) aims to build explainable and interpretable machine learning (or deep learning) methods without sacrificing prediction performance. Convolutional Neural Networks (CNNs) have been successful in making predictions, especially in image classification. However, these famous deep learning models use tens of millions of parameters based on a large number of pre-trained filters which have been repurposed from previous data sets. We propose a novel Interaction-based Convolutional Neural Network (ICNN) that does not make assumptions about the relevance of local information. Instead, we use a model-free Influence Score (I-score) to directly extract the influential information from images to form important variable modules. We demonstrate that the proposed method produces state-of-the-art prediction performance of 99.8% on a real-world data set classifying COVID-19 Chest X-ray images without sacrificing the explanatory power of the model. This proposed design can efficiently screen COVID-19 patients before human diagnosis, and will be the benchmark for addressing future XAI problems in large-scale data sets.

Prototype models are an important method for explainable artificial intelligence (XAI) and interpretable machine learning. In this paper, we perform an in-depth analysis of a set of prominent prototype models including ProtoPNet, ProtoPool and PIPNet. For their assessment, we apply a comprehensive set of metrics. In addition to applying standard metrics from literature, we propose several new metrics to further complement the analysis of model interpretability. In our experimentation, we apply the set of prototype models on a diverse set of datasets including fine-grained classification, Non-IID settings and multi-label classification to further contrast the performance. Furthermore, we also provide our code as an open-source library (https://github.com/uos-sis/quanproto), which facilitates simple application of the metrics itself, as well as extensibility -- providing the option for easily adding new metrics and models.

Brain stroke remains one of the principal causes of death and disability worldwide, yet most tabular-data prediction models still hover below the 95% accuracy threshold, limiting real-world utility. Addressing this gap, the present work develops and validates a completely data-driven and interpretable machine-learning framework designed to predict strokes using ten routinely gathered demographic, lifestyle, and clinical variables sourced from a public cohort of 4,981 records. We employ a detailed exploratory data analysis (EDA) to understand the dataset's structure and distribution, followed by rigorous data preprocessing, including handling missing values, outlier removal, and class imbalance correction using Synthetic Minority Over-sampling Technique (SMOTE). To streamline feature selection, point-biserial correlation and random-forest Gini importance were utilized, and ten varied algorithms-encompassing tree ensembles, boosting, kernel methods, and a multilayer neural network-were optimized using stratified five-fold cross-validation. Their predictions based on probabilities helped us build the proposed model, which included Random Forest, XGBoost, LightGBM, and a support-vector classifier, with logistic regression acting as a meta-learner. The proposed model achieved an accuracy rate of 97.2% and an F1-score of 97.15%, indicating a significant enhancement compared to the leading individual model, LightGBM, which had an accuracy of 91.4%. Our study's findings indicate that rigorous preprocessing, coupled with a diverse hybrid model, can convert low-cost tabular data into a nearly clinical-grade stroke-risk assessment tool.

With the rise of Large Language Models (LLMs), the novel metric "Brainscore" emerged as a means to evaluate the functional similarity between LLMs and human brain/neural systems. Our efforts were dedicated to mining the meaning of the novel score by constructing topological features derived from both human fMRI data involving 190 subjects, and 39 LLMs plus their untrained counterparts. Subsequently, we trained 36 Linear Regression Models and conducted thorough statistical analyses to discern reliable and valid features from our constructed ones. Our findings reveal distinctive feature combinations conducive to interpreting existing brainscores across various brain regions of interest (ROIs) and hemispheres, thereby significantly contributing to advancing interpretable machine learning (iML) studies. The study is enriched by our further discussions and analyses concerning existing brainscores. To our knowledge, this study represents the first attempt to comprehend the novel metric brainscore within this interdisciplinary domain.

Learning self-supervised representations that are invariant and equivariant to transformations is crucial for advancing beyond traditional visual classification tasks. However, many methods rely on predictor architectures to encode equivariance, despite evidence that architectural choices, such as capsule networks, inherently excel at learning interpretable pose-aware representations. To explore this, we introduce EquiCaps (Equivariant Capsule Network), a capsule-based approach to pose-aware self-supervision that eliminates the need for a specialised predictor for enforcing equivariance. Instead, we leverage the intrinsic pose-awareness capabilities of capsules to improve performance in pose estimation tasks. To further challenge our assumptions, we increase task complexity via multi-geometric transformations to enable a more thorough evaluation of invariance and equivariance by introducing 3DIEBench-T, an extension of a 3D object-rendering benchmark dataset. Empirical results demonstrate that EquiCaps outperforms prior state-of-the-art equivariant methods on rotation prediction, achieving a supervised-level R^2 of 0.78 on the 3DIEBench rotation prediction benchmark and improving upon SIE and CapsIE by 0.05 and 0.04 R^2, respectively. Moreover, in contrast to non-capsule-based equivariant approaches, EquiCaps maintains robust equivariant performance under combined geometric transformations, underscoring its generalisation capabilities and the promise of predictor-free capsule architectures.

We present POTATO, a task- and languageindependent framework for human-in-the-loop (HITL) learning of rule-based text classifiers using graph-based features. POTATO handles any type of directed graph and supports parsing text into Abstract Meaning Representations (AMR), Universal Dependencies (UD), and 4lang semantic graphs. A streamlit-based user interface allows users to build rule systems from graph patterns, provides real-time evaluation based on ground truth data, and suggests rules by ranking graph features using interpretable machine learning models. Users can also provide patterns over graphs using regular expressions, and POTATO can recommend refinements of such rules. POTATO is applied in projects across domains and languages, including classification tasks on German legal text and English social media data. All components of our system are written in Python, can be installed via pip, and are released under an MIT License on GitHub.

Large-scale vision-language models (VLMs), such as CLIP, have achieved remarkable success in zero-shot learning (ZSL) by leveraging large-scale visual-text pair datasets. However, these methods often lack interpretability, as they compute the similarity between an entire query image and the embedded category words, making it difficult to explain their predictions. One approach to address this issue is to develop interpretable models by integrating language, where classifiers are built using discrete attributes, similar to human perception. This introduces a new challenge: how to effectively align local visual features with corresponding attributes based on pre-trained VLMs. To tackle this, we propose LaZSL, a locally-aligned vision-language model for interpretable ZSL. LaZSL employs local visual-semantic alignment via optimal transport to perform interaction between visual regions and their associated attributes, facilitating effective alignment and providing interpretable similarity without the need for additional training. Extensive experiments demonstrate that our method offers several advantages, including enhanced interpretability, improved accuracy, and strong domain generalization. Codes available at: https://github.com/shiming-chen/LaZSL.

Continual learning enables incremental learning of new tasks without forgetting those previously learned, resulting in positive knowledge transfer that can enhance performance on both new and old tasks. However, continual learning poses new challenges for interpretability, as the rationale behind model predictions may change over time, leading to interpretability concept drift. We address this problem by proposing Interpretable Class-InCremental LEarning (ICICLE), an exemplar-free approach that adopts a prototypical part-based approach. It consists of three crucial novelties: interpretability regularization that distills previously learned concepts while preserving user-friendly positive reasoning; proximity-based prototype initialization strategy dedicated to the fine-grained setting; and task-recency bias compensation devoted to prototypical parts. Our experimental results demonstrate that ICICLE reduces the interpretability concept drift and outperforms the existing exemplar-free methods of common class-incremental learning when applied to concept-based models.

Humans recognize objects after observing only a few examples, a remarkable capability enabled by their inherent language understanding of the real-world environment. Developing verbalized and interpretable representation can significantly improve model generalization in low-data settings. In this work, we propose Verbalized Representation Learning (VRL), a novel approach for automatically extracting human-interpretable features for object recognition using few-shot data. Our method uniquely captures inter-class differences and intra-class commonalities in the form of natural language by employing a Vision-Language Model (VLM) to identify key discriminative features between different classes and shared characteristics within the same class. These verbalized features are then mapped to numeric vectors through the VLM. The resulting feature vectors can be further utilized to train and infer with downstream classifiers. Experimental results show that, at the same model scale, VRL achieves a 24% absolute improvement over prior state-of-the-art methods while using 95% less data and a smaller mode. Furthermore, compared to human-labeled attributes, the features learned by VRL exhibit a 20% absolute gain when used for downstream classification tasks. Code is available at: https://github.com/joeyy5588/VRL/tree/main.

Reinforcement learning agents deployed in the real world often have to cope with partially observable environments. Therefore, most agents employ memory mechanisms to approximate the state of the environment. Recently, there have been impressive success stories in mastering partially observable environments, mostly in the realm of computer games like Dota 2, StarCraft II, or MineCraft. However, none of these methods are interpretable in the sense that it is not comprehensible for humans how the agent decides which actions to take based on its inputs. Yet, human understanding is necessary in order to deploy such methods in high-stake domains like autonomous driving or medical applications. We propose a novel memory mechanism that operates on human language to illuminate the decision-making process. First, we use CLIP to associate visual inputs with language tokens. Then we feed these tokens to a pretrained language model that serves the agent as memory and provides it with a coherent and interpretable representation of the past. Our memory mechanism achieves state-of-the-art performance in environments where memorizing the past is crucial to solve tasks. Further, we present situations where our memory component excels or fails to demonstrate strengths and weaknesses of our new approach.

When we are faced with challenging image classification tasks, we often explain our reasoning by dissecting the image, and pointing out prototypical aspects of one class or another. The mounting evidence for each of the classes helps us make our final decision. In this work, we introduce a deep network architecture -- prototypical part network (ProtoPNet), that reasons in a similar way: the network dissects the image by finding prototypical parts, and combines evidence from the prototypes to make a final classification. The model thus reasons in a way that is qualitatively similar to the way ornithologists, physicians, and others would explain to people on how to solve challenging image classification tasks. The network uses only image-level labels for training without any annotations for parts of images. We demonstrate our method on the CUB-200-2011 dataset and the Stanford Cars dataset. Our experiments show that ProtoPNet can achieve comparable accuracy with its analogous non-interpretable counterpart, and when several ProtoPNets are combined into a larger network, it can achieve an accuracy that is on par with some of the best-performing deep models. Moreover, ProtoPNet provides a level of interpretability that is absent in other interpretable deep models.

We generalise the problem of reward modelling (RM) for reinforcement learning (RL) to handle non-Markovian rewards. Existing work assumes that human evaluators observe each step in a trajectory independently when providing feedback on agent behaviour. In this work, we remove this assumption, extending RM to capture temporal dependencies in human assessment of trajectories. We show how RM can be approached as a multiple instance learning (MIL) problem, where trajectories are treated as bags with return labels, and steps within the trajectories are instances with unseen reward labels. We go on to develop new MIL models that are able to capture the time dependencies in labelled trajectories. We demonstrate on a range of RL tasks that our novel MIL models can reconstruct reward functions to a high level of accuracy, and can be used to train high-performing agent policies.

Multi-Agent Deep Reinforcement Learning (MADRL) was proven efficient in solving complex problems in robotics or games, yet most of the trained models are hard to interpret. While learning intrinsically interpretable models remains a prominent approach, its scalability and flexibility are limited in handling complex tasks or multi-agent dynamics. This paper advocates for direct interpretability, generating post hoc explanations directly from trained models, as a versatile and scalable alternative, offering insights into agents' behaviour, emergent phenomena, and biases without altering models' architectures. We explore modern methods, including relevance backpropagation, knowledge edition, model steering, activation patching, sparse autoencoders and circuit discovery, to highlight their applicability to single-agent, multi-agent, and training process challenges. By addressing MADRL interpretability, we propose directions aiming to advance active topics such as team identification, swarm coordination and sample efficiency.

Sparse dictionary learning has been a rapidly growing technique in mechanistic interpretability to attack superposition and extract more human-understandable features from model activations. We ask a further question based on the extracted more monosemantic features: How do we recognize circuits connecting the enormous amount of dictionary features? We propose a circuit discovery framework alternative to activation patching. Our framework suffers less from out-of-distribution and proves to be more efficient in terms of asymptotic complexity. The basic unit in our framework is dictionary features decomposed from all modules writing to the residual stream, including embedding, attention output and MLP output. Starting from any logit, dictionary feature or attention score, we manage to trace down to lower-level dictionary features of all tokens and compute their contribution to these more interpretable and local model behaviors. We dig in a small transformer trained on a synthetic task named Othello and find a number of human-understandable fine-grained circuits inside of it.

Deep Learning based models are currently dominating most state-of-the-art solutions for disease prediction. Existing works employ RNNs along with multiple levels of attention mechanisms to provide interpretability. These deep learning models, with trainable parameters running into millions, require huge amounts of compute and data to train and deploy. These requirements are sometimes so huge that they render usage of such models as unfeasible. We address these challenges by developing a simpler yet interpretable non-deep learning based model for application to EHR data. We model and showcase our work's results on the task of predicting first occurrence of a diagnosis, often overlooked in existing works. We push the capabilities of a tree based model and come up with a strong baseline for more sophisticated models. Its performance shows an improvement over deep learning based solutions (both, with and without the first-occurrence constraint) all the while maintaining interpretability.

Accurately grounding regions of interest (ROIs) is critical for diagnosis and treatment planning in medical imaging. While multimodal large language models (MLLMs) combine visual perception with natural language, current medical-grounding pipelines still rely on supervised fine-tuning with explicit spatial hints, making them ill-equipped to handle the implicit queries common in clinical practice. This work makes three core contributions. We first define Unified Medical Reasoning Grounding (UMRG), a novel vision-language task that demands clinical reasoning and pixel-level grounding. Second, we release U-MRG-14K, a dataset of 14K samples featuring pixel-level masks alongside implicit clinical queries and reasoning traces, spanning 10 modalities, 15 super-categories, and 108 specific categories. Finally, we introduce MedReasoner, a modular framework that distinctly separates reasoning from segmentation: an MLLM reasoner is optimized with reinforcement learning, while a frozen segmentation expert converts spatial prompts into masks, with alignment achieved through format and accuracy rewards. MedReasoner achieves state-of-the-art performance on U-MRG-14K and demonstrates strong generalization to unseen clinical queries, underscoring the significant promise of reinforcement learning for interpretable medical grounding.

Off-policy learning (OPL) aims at finding improved policies from logged bandit data, often by minimizing the inverse propensity scoring (IPS) estimator of the risk. In this work, we investigate a smooth regularization for IPS, for which we derive a two-sided PAC-Bayes generalization bound. The bound is tractable, scalable, interpretable and provides learning certificates. In particular, it is also valid for standard IPS without making the assumption that the importance weights are bounded. We demonstrate the relevance of our approach and its favorable performance through a set of learning tasks. Since our bound holds for standard IPS, we are able to provide insight into when regularizing IPS is useful. Namely, we identify cases where regularization might not be needed. This goes against the belief that, in practice, clipped IPS often enjoys favorable performance than standard IPS in OPL.

Medical image classification requires not only high predictive performance but also interpretability to ensure clinical trust and adoption. Graph Neural Networks (GNNs) offer a powerful framework for modeling relational structures within datasets; however, standard GNNs often operate as black boxes, limiting transparency and usability, particularly in clinical settings. In this work, we present an interpretable graph-based learning framework named FireGNN that integrates trainable fuzzy rules into GNNs for medical image classification. These rules embed topological descriptors - node degree, clustering coefficient, and label agreement - using learnable thresholds and sharpness parameters to enable intrinsic symbolic reasoning. Additionally, we explore auxiliary self-supervised tasks (e.g., homophily prediction, similarity entropy) as a benchmark to evaluate the contribution of topological learning. Our fuzzy-rule-enhanced model achieves strong performance across five MedMNIST benchmarks and the synthetic dataset MorphoMNIST, while also generating interpretable rule-based explanations. To our knowledge, this is the first integration of trainable fuzzy rules within a GNN. Source Code: https://github.com/basiralab/FireGNN

Retrosynthesis prediction aims to infer the reactant molecule based on a given product molecule, which is a fundamental task in chemical synthesis. However, existing models rely on static pattern-matching paradigm, which limits their ability to perform effective logic decision-making, leading to black-box decision-making. Building on this, we propose Retro-Expert, an interpretable retrosynthesis framework that performs collaborative reasoning by combining the complementary reasoning strengths of Large Language Models and specialized models via reinforcement learning. It outputs natural language explanations grounded in chemical logic through three components: (1) specialized models perform shallow reasoning to construct high-quality chemical decision space, (2) LLM-driven critical reasoning to generate predictions and corresponding interpretable reasoning path, and (3) reinforcement learning optimizing interpretable decision policy. Experiments show that Retro-Expert not only surpasses both LLM-based and specialized models across different metrics but also provides expert-aligned explanations that bridge the gap between AI predictions and actionable chemical insights.

In order to develop machine learning and deep learning models that take into account the guidelines and principles of trustworthy AI, a novel information theoretic trustworthy AI framework is introduced. A unified approach to "privacy-preserving interpretable and transferable learning" is considered for studying and optimizing the tradeoffs between privacy, interpretability, and transferability aspects. A variational membership-mapping Bayesian model is used for the analytical approximations of the defined information theoretic measures for privacy-leakage, interpretability, and transferability. The approach consists of approximating the information theoretic measures via maximizing a lower-bound using variational optimization. The study presents a unified information theoretic approach to study different aspects of trustworthy AI in a rigorous analytical manner. The approach is demonstrated through numerous experiments on benchmark datasets and a real-world biomedical application concerned with the detection of mental stress on individuals using heart rate variability analysis.

Despite widespread adoption, machine learning models remain mostly black boxes. Understanding the reasons behind predictions is, however, quite important in assessing trust, which is fundamental if one plans to take action based on a prediction, or when choosing whether to deploy a new model. Such understanding also provides insights into the model, which can be used to transform an untrustworthy model or prediction into a trustworthy one. In this work, we propose LIME, a novel explanation technique that explains the predictions of any classifier in an interpretable and faithful manner, by learning an interpretable model locally around the prediction. We also propose a method to explain models by presenting representative individual predictions and their explanations in a non-redundant way, framing the task as a submodular optimization problem. We demonstrate the flexibility of these methods by explaining different models for text (e.g. random forests) and image classification (e.g. neural networks). We show the utility of explanations via novel experiments, both simulated and with human subjects, on various scenarios that require trust: deciding if one should trust a prediction, choosing between models, improving an untrustworthy classifier, and identifying why a classifier should not be trusted.

Model interpretability is a requirement in many applications in which crucial decisions are made by users relying on a model's outputs. The recent movement for "algorithmic fairness" also stipulates explainability, and therefore interpretability of learning models. And yet the most successful contemporary Machine Learning approaches, the Deep Neural Networks, produce models that are highly non-interpretable. We attempt to address this challenge by proposing a technique called CNN-INTE to interpret deep Convolutional Neural Networks (CNN) via meta-learning. In this work, we interpret a specific hidden layer of the deep CNN model on the MNIST image dataset. We use a clustering algorithm in a two-level structure to find the meta-level training data and Random Forest as base learning algorithms to generate the meta-level test data. The interpretation results are displayed visually via diagrams, which clearly indicates how a specific test instance is classified. Our method achieves global interpretation for all the test instances without sacrificing the accuracy obtained by the original deep CNN model. This means our model is faithful to the deep CNN model, which leads to reliable interpretations.

Multi-Agent Reinforcement Learning (MARL) is increasingly deployed in safety-critical domains, yet methods for interpretable failure detection and attribution remain underdeveloped. We introduce a two-stage gradient-based framework that provides interpretable diagnostics for three critical failure analysis tasks: (1) detecting the true initial failure source (Patient-0); (2) validating why non-attacked agents may be flagged first due to domino effects; and (3) tracing how failures propagate through learned coordination pathways. Stage 1 performs interpretable per-agent failure detection via Taylor-remainder analysis of policy-gradient costs, declaring an initial Patient-0 candidate at the first threshold crossing. Stage 2 provides validation through geometric analysis of critic derivatives-first-order sensitivity and directional second-order curvature aggregated over causal windows to construct interpretable contagion graphs. This approach explains "downstream-first" detection anomalies by revealing pathways that amplify upstream deviations. Evaluated across 500 episodes in Simple Spread (3 and 5 agents) and 100 episodes in StarCraft II using MADDPG and HATRPO, our method achieves 88.2-99.4% Patient-0 detection accuracy while providing interpretable geometric evidence for detection decisions. By moving beyond black-box detection to interpretable gradient-level forensics, this framework offers practical tools for diagnosing cascading failures in safety-critical MARL systems.

Obesity, the leading cause of many non-communicable diseases, occurs mainly for eating more than our body requirements and lack of proper activity. So, being healthy requires heathy diet plans, especially for patients with comorbidities. But it is difficult to figure out the exact quantity of each nutrient because nutrients requirement varies based on physical and disease conditions. In our study we proposed a novel machine learning based system to predict the amount of nutrients one individual requires for being healthy. We applied different machine learning algorithms: linear regression, support vector machine (SVM), decision tree, random forest, XGBoost, LightGBM on fluid and 3 other major micronutrients: carbohydrate, protein, fat consumption prediction. We achieved high accuracy with low root mean square error (RMSE) by using linear regression in fluid prediction, random forest in carbohydrate prediction and LightGBM in protein and fat prediction. We believe our diet recommender system, OBESEYE, is the only of its kind which recommends diet with the consideration of comorbidities and physical conditions and promote encouragement to get rid of obesity.

Deep reinforcement learning (RL) has shown remarkable success in complex domains, however, the inherent black box nature of deep neural network policies raises significant challenges in understanding and trusting the decision-making processes. While existing explainable RL methods provide local insights, they fail to deliver a global understanding of the model, particularly in high-stakes applications. To overcome this limitation, we propose a novel model-agnostic approach that bridges the gap between explainability and interpretability by leveraging Shapley values to transform complex deep RL policies into transparent representations. The proposed approach offers two key contributions: a novel approach employing Shapley values to policy interpretation beyond local explanations and a general framework applicable to off-policy and on-policy algorithms. We evaluate our approach with three existing deep RL algorithms and validate its performance in two classic control environments. The results demonstrate that our approach not only preserves the original models' performance but also generates more stable interpretable policies.

Human-interpretable predictions are essential for deploying AI in medical imaging, yet most interpretable-by-design (IBD) frameworks require concept annotations for training data, which are costly and impractical to obtain in clinical contexts. Recent attempts to bypass annotation, such as zero-shot vision-language models or concept-generation frameworks, struggle to capture domain-specific medical features, leading to poor reliability. In this paper, we propose a novel Prior-guided Concept Predictor (PCP), a weakly supervised framework that enables concept answer prediction without explicit supervision or reliance on language models. PCP leverages class-level concept priors as weak supervision and incorporates a refinement mechanism with KL divergence and entropy regularization to align predictions with clinical reasoning. Experiments on PH2 (dermoscopy) and WBCatt (hematology) show that PCP improves concept-level F1-score by over 33% compared to zero-shot baselines, while delivering competitive classification performance on four medical datasets (PH2, WBCatt, HAM10000, and CXR4) relative to fully supervised concept bottleneck models (CBMs) and V-IP.

Prototype-based neural networks offer interpretable predictions by comparing inputs to learned, representative signal patterns anchored in training data. While such models have shown promise in the classification of physiological data, it remains unclear whether their prototypes capture an underlying structure that aligns with broader clinical phenotypes. We use a prototype-based deep learning model trained for multi-label ECG classification using the PTB-XL dataset. Then without modification we performed inference on the MIMIC-IV clinical database. We assess whether individual prototypes, trained solely for classification, are associated with hospital discharge diagnoses in the form of phecodes in this external population. Individual prototypes demonstrate significantly stronger and more specific associations with clinical outcomes compared to the classifier's class predictions, NLP-extracted concepts, or broader prototype classes across all phecode categories. Prototype classes with mixed significance patterns exhibit significantly greater intra-class distances (p < 0.0001), indicating the model learned to differentiate clinically meaningful variations within diagnostic categories. The prototypes achieve strong predictive performance across diverse conditions, with AUCs ranging from 0.89 for atrial fibrillation to 0.91 for heart failure, while also showing substantial signal for non-cardiac conditions such as sepsis and renal disease. These findings suggest that prototype-based models can support interpretable digital phenotyping from physiologic time-series data, providing transferable intermediate phenotypes that capture clinically meaningful physiologic signatures beyond their original training objectives.

Deep reinforcement learning (DRL) has shown significant promise for uncovering sophisticated control policies that interact in environments with complicated dynamics, such as stabilizing the magnetohydrodynamics of a tokamak fusion reactor or minimizing the drag force exerted on an object in a fluid flow. However, these algorithms require an abundance of training examples and may become prohibitively expensive for many applications. In addition, the reliance on deep neural networks often results in an uninterpretable, black-box policy that may be too computationally expensive to use with certain embedded systems. Recent advances in sparse dictionary learning, such as the sparse identification of nonlinear dynamics (SINDy), have shown promise for creating efficient and interpretable data-driven models in the low-data regime. In this work we introduce SINDy-RL, a unifying framework for combining SINDy and DRL to create efficient, interpretable, and trustworthy representations of the dynamics model, reward function, and control policy. We demonstrate the effectiveness of our approaches on benchmark control environments and challenging fluids problems. SINDy-RL achieves comparable performance to state-of-the-art DRL algorithms using significantly fewer interactions in the environment and results in an interpretable control policy orders of magnitude smaller than a deep neural network policy.

Recently, finetuning a pretrained language model to capture the similarity between sentence embeddings has shown the state-of-the-art performance on the semantic textual similarity (STS) task. However, the absence of an interpretation method for the sentence similarity makes it difficult to explain the model output. In this work, we explicitly describe the sentence distance as the weighted sum of contextualized token distances on the basis of a transportation problem, and then present the optimal transport-based distance measure, named RCMD; it identifies and leverages semantically-aligned token pairs. In the end, we propose CLRCMD, a contrastive learning framework that optimizes RCMD of sentence pairs, which enhances the quality of sentence similarity and their interpretation. Extensive experiments demonstrate that our learning framework outperforms other baselines on both STS and interpretable-STS benchmarks, indicating that it computes effective sentence similarity and also provides interpretation consistent with human judgement. The code and checkpoint are publicly available at https://github.com/sh0416/clrcmd.

In order to make accurate predictions of material properties, current machine-learning approaches generally require large amounts of data, which are often not available in practice. In this work, an all-round framework is presented which relies on a feedforward neural network, the selection of physically-meaningful features and, when applicable, joint-learning. Next to being faster in terms of training time, this approach is shown to outperform current graph-network models on small datasets. In particular, the vibrational entropy at 305 K of crystals is predicted with a mean absolute test error of 0.009 meV/K/atom (four times lower than previous studies). Furthermore, joint-learning reduces the test error compared to single-target learning and enables the prediction of multiple properties at once, such as temperature functions. Finally, the selection algorithm highlights the most important features and thus helps understanding the underlying physics.

Single-cell RNA sequencing (scRNA-seq) data are often confounded by technical or biological batch effects. Existing deep learning models mitigate these effects but often discard batch-specific information, potentially losing valuable biological insights. We propose a Mixed Effects Deep Learning (MEDL) autoencoder framework that separately models batch-invariant (fixed effects) and batch-specific (random effects) components. By decoupling batch-invariant biological states from batch variations, our framework integrates both into predictive models. Our approach also generates 2D visualizations of how the same cell appears across batches, enhancing interpretability. Retaining both fixed and random effect latent spaces improves classification accuracy. We applied our framework to three datasets spanning the cardiovascular system (Healthy Heart), Autism Spectrum Disorder (ASD), and Acute Myeloid Leukemia (AML). With 147 batches in the Healthy Heart dataset, far exceeding typical numbers, we tested our framework's ability to handle many batches. In the ASD dataset, our approach captured donor heterogeneity between autistic and healthy individuals. In the AML dataset, it distinguished donor heterogeneity despite missing cell types and diseased donors exhibiting both healthy and malignant cells. These results highlight our framework's ability to characterize fixed and random effects, enhance batch effect visualization, and improve prediction accuracy across diverse datasets.

Conventional Time Series Classification (TSC) methods are often black boxes that obscure inherent interpretation of their decision-making processes. In this work, we leverage Multiple Instance Learning (MIL) to overcome this issue, and propose a new framework called MILLET: Multiple Instance Learning for Locally Explainable Time series classification. We apply MILLET to existing deep learning TSC models and show how they become inherently interpretable without compromising (and in some cases, even improving) predictive performance. We evaluate MILLET on 85 UCR TSC datasets and also present a novel synthetic dataset that is specially designed to facilitate interpretability evaluation. On these datasets, we show MILLET produces sparse explanations quickly that are of higher quality than other well-known interpretability methods. To the best of our knowledge, our work with MILLET, which is available on GitHub (https://github.com/JAEarly/MILTimeSeriesClassification), is the first to develop general MIL methods for TSC and apply them to an extensive variety of domains

Medical visual question answering (VQA) aims to answer clinically relevant questions regarding input medical images. This technique has the potential to improve the efficiency of medical professionals while relieving the burden on the public health system, particularly in resource-poor countries. Existing medical VQA methods tend to encode medical images and learn the correspondence between visual features and questions without exploiting the spatial, semantic, or medical knowledge behind them. This is partially because of the small size of the current medical VQA dataset, which often includes simple questions. Therefore, we first collected a comprehensive and large-scale medical VQA dataset, focusing on chest X-ray images. The questions involved detailed relationships, such as disease names, locations, levels, and types in our dataset. Based on this dataset, we also propose a novel baseline method by constructing three different relationship graphs: spatial relationship, semantic relationship, and implicit relationship graphs on the image regions, questions, and semantic labels. The answer and graph reasoning paths are learned for different questions.

Prototypical part network (ProtoPNet) methods have been designed to achieve interpretable classification by associating predictions with a set of training prototypes, which we refer to as trivial prototypes because they are trained to lie far from the classification boundary in the feature space. Note that it is possible to make an analogy between ProtoPNet and support vector machine (SVM) given that the classification from both methods relies on computing similarity with a set of training points (i.e., trivial prototypes in ProtoPNet, and support vectors in SVM). However, while trivial prototypes are located far from the classification boundary, support vectors are located close to this boundary, and we argue that this discrepancy with the well-established SVM theory can result in ProtoPNet models with inferior classification accuracy. In this paper, we aim to improve the classification of ProtoPNet with a new method to learn support prototypes that lie near the classification boundary in the feature space, as suggested by the SVM theory. In addition, we target the improvement of classification results with a new model, named ST-ProtoPNet, which exploits our support prototypes and the trivial prototypes to provide more effective classification. Experimental results on CUB-200-2011, Stanford Cars, and Stanford Dogs datasets demonstrate that ST-ProtoPNet achieves state-of-the-art classification accuracy and interpretability results. We also show that the proposed support prototypes tend to be better localised in the object of interest rather than in the background region.

Without relevant human priors, neural networks may learn uninterpretable features. We propose Dynamics of Attention for Focus Transition (DAFT) as a human prior for machine reasoning. DAFT is a novel method that regularizes attention-based reasoning by modelling it as a continuous dynamical system using neural ordinary differential equations. As a proof of concept, we augment a state-of-the-art visual reasoning model with DAFT. Our experiments reveal that applying DAFT yields similar performance to the original model while using fewer reasoning steps, showing that it implicitly learns to skip unnecessary steps. We also propose a new metric, Total Length of Transition (TLT), which represents the effective reasoning step size by quantifying how much a given model's focus drifts while reasoning about a question. We show that adding DAFT results in lower TLT, demonstrating that our method indeed obeys the human prior towards shorter reasoning paths in addition to producing more interpretable attention maps. Our code is available at https://github.com/kakao/DAFT.

Building generalizable AI models is one of the primary challenges in the healthcare domain. While radiologists rely on generalizable descriptive rules of abnormality, Neural Network (NN) models suffer even with a slight shift in input distribution (e.g., scanner type). Fine-tuning a model to transfer knowledge from one domain to another requires a significant amount of labeled data in the target domain. In this paper, we develop an interpretable model that can be efficiently fine-tuned to an unseen target domain with minimal computational cost. We assume the interpretable component of NN to be approximately domain-invariant. However, interpretable models typically underperform compared to their Blackbox (BB) variants. We start with a BB in the source domain and distill it into a mixture of shallow interpretable models using human-understandable concepts. As each interpretable model covers a subset of data, a mixture of interpretable models achieves comparable performance as BB. Further, we use the pseudo-labeling technique from semi-supervised learning (SSL) to learn the concept classifier in the target domain, followed by fine-tuning the interpretable models in the target domain. We evaluate our model using a real-life large-scale chest-X-ray (CXR) classification dataset. The code is available at: https://github.com/batmanlab/MICCAI-2023-Route-interpret-repeat-CXRs.

Vision foundation models (FMs) achieve state-of-the-art performance in medical imaging. However, they encode information in abstract latent representations that clinicians cannot interrogate or verify. The goal of this study is to investigate Sparse Autoencoders (SAEs) for replacing opaque FM image representations with human-interpretable, sparse features. We train SAEs on embeddings from BiomedParse (biomedical) and DINOv3 (general-purpose) using 909,873 CT and MRI 2D image slices from the TotalSegmentator dataset. We find that learned sparse features: (a) reconstruct original embeddings with high fidelity (R2 up to 0.941) and recover up to 87.8% of downstream performance using only 10 features (99.4% dimensionality reduction), (b) preserve semantic fidelity in image retrieval tasks, (c) correspond to specific concepts that can be expressed in language using large language model (LLM)-based auto-interpretation. (d) bridge clinical language and abstract latent representations in zero-shot language-driven image retrieval. Our work indicates SAEs are a promising pathway towards interpretable, concept-driven medical vision systems. Code repository: https://github.com/pwesp/sail.

Optimal operation of chemical processes is vital for energy, resource, and cost savings in chemical engineering. The problem of optimal operation can be tackled with reinforcement learning, but traditional reinforcement learning methods face challenges due to hard constraints related to quality and safety that must be strictly satisfied, and the large amount of required training data. Chemical processes often cannot provide sufficient experimental data, and while detailed dynamic models can be an alternative, their complexity makes it computationally intractable to generate the needed data. Optimal control methods, such as model predictive control, also struggle with the complexity of the underlying dynamic models. Consequently, many chemical processes rely on manually defined operation recipes combined with simple linear controllers, leading to suboptimal performance and limited flexibility. In this work, we propose a novel approach that leverages expert knowledge embedded in operation recipes. By using reinforcement learning to optimize the parameters of these recipes and their underlying linear controllers, we achieve an optimized operation recipe. This method requires significantly less data, handles constraints more effectively, and is more interpretable than traditional reinforcement learning methods due to the structured nature of the recipes. We demonstrate the potential of our approach through simulation results of an industrial batch polymerization reactor, showing that it can approach the performance of optimal controllers while addressing the limitations of existing methods.

Model-Free Reinforcement Learning (RL) algorithms either learn how to map states to expected rewards or search for policies that can maximize a certain performance function. Model-Based algorithms instead, aim to learn an approximation of the underlying model of the RL environment and then use it in combination with planning algorithms. Upside-Down Reinforcement Learning (UDRL) is a novel learning paradigm that aims to learn how to predict actions from states and desired commands. This task is formulated as a Supervised Learning problem and has successfully been tackled by Neural Networks (NNs). In this paper, we investigate whether function approximation algorithms other than NNs can also be used within a UDRL framework. Our experiments, performed over several popular optimal control benchmarks, show that tree-based methods like Random Forests and Extremely Randomized Trees can perform just as well as NNs with the significant benefit of resulting in policies that are inherently more interpretable than NNs, therefore paving the way for more transparent, safe, and robust RL.

Sepsis remains one of the leading causes of mortality in intensive care units, where timely and accurate treatment decisions can significantly impact patient outcomes. In this work, we propose an interpretable decision support framework. Our system integrates four core components: (1) a clustering-based stratification module that categorizes patients into low, intermediate, and high-risk groups upon ICU admission, using clustering with statistical validation; (2) a synthetic data augmentation pipeline leveraging variational autoencoders (VAE) and diffusion models to enrich underrepresented trajectories such as fluid or vasopressor administration; (3) an offline reinforcement learning (RL) agent trained using Advantage Weighted Regression (AWR) with a lightweight attention encoder and supported by an ensemble models for conservative, safety-aware treatment recommendations; and (4) a rationale generation module powered by a multi-modal large language model (LLM), which produces natural-language justifications grounded in clinical context and retrieved expert knowledge. Evaluated on the MIMIC-III and eICU datasets, our approach achieves high treatment accuracy while providing clinicians with interpretable and robust policy recommendations.

Generative models have been very popular in the recent years for their image generation capabilities. GAN-based models are highly regarded for their disentangled latent space, which is a key feature contributing to their success in controlled image editing. On the other hand, diffusion models have emerged as powerful tools for generating high-quality images. However, the latent space of diffusion models is not as thoroughly explored or understood. Existing methods that aim to explore the latent space of diffusion models usually relies on text prompts to pinpoint specific semantics. However, this approach may be restrictive in areas such as art, fashion, or specialized fields like medicine, where suitable text prompts might not be available or easy to conceive thus limiting the scope of existing work. In this paper, we propose an unsupervised method to discover latent semantics in text-to-image diffusion models without relying on text prompts. Our method takes a small set of unlabeled images from specific domains, such as faces or cats, and a pre-trained diffusion model, and discovers diverse semantics in unsupervised fashion using a contrastive learning objective. Moreover, the learned directions can be applied simultaneously, either within the same domain (such as various types of facial edits) or across different domains (such as applying cat and face edits within the same image) without interfering with each other. Our extensive experiments show that our method achieves highly disentangled edits, outperforming existing approaches in both diffusion-based and GAN-based latent space editing methods.

Recently, deep learning models have made great progress in MWP solving on answer accuracy. However, they are uninterpretable since they mainly rely on shallow heuristics to achieve high performance without understanding and reasoning the grounded math logic. To address this issue and make a step towards interpretable MWP solving, we first construct a high-quality MWP dataset named InterMWP which consists of 11,495 MWPs and annotates interpretable logical formulas based on algebraic knowledge as the grounded linguistic logic of each solution equation. Different from existing MWP datasets, our InterMWP benchmark asks for a solver to not only output the solution expressions but also predict the corresponding logical formulas. We further propose a novel approach with logical prompt and interpretation generation, called LogicSolver. For each MWP, our LogicSolver first retrieves some highly-correlated algebraic knowledge and then passes them to the backbone model as prompts to improve the semantic representations of MWPs. With these improved semantic representations, our LogicSolver generates corresponding solution expressions and interpretable knowledge formulas in accord with the generated solution expressions, simultaneously. Experimental results show that our LogicSolver has stronger logical formula-based interpretability than baselines while achieving higher answer accuracy with the help of logical prompts, simultaneously. The source code and dataset is available at https://github.com/yangzhch6/InterMWP.

Expert problem-solving is driven by powerful languages for thinking about problems and their solutions. Acquiring expertise means learning these languages -- systems of concepts, alongside the skills to use them. We present DreamCoder, a system that learns to solve problems by writing programs. It builds expertise by creating programming languages for expressing domain concepts, together with neural networks to guide the search for programs within these languages. A ``wake-sleep'' learning algorithm alternately extends the language with new symbolic abstractions and trains the neural network on imagined and replayed problems. DreamCoder solves both classic inductive programming tasks and creative tasks such as drawing pictures and building scenes. It rediscovers the basics of modern functional programming, vector algebra and classical physics, including Newton's and Coulomb's laws. Concepts are built compositionally from those learned earlier, yielding multi-layered symbolic representations that are interpretable and transferrable to new tasks, while still growing scalably and flexibly with experience.

Perceptual similarity scores that align with human vision are critical for both training and evaluating computer vision models. Deep perceptual losses, such as LPIPS, achieve good alignment but rely on complex, highly non-linear discriminative features with unknown invariances, while hand-crafted measures like SSIM are interpretable but miss key perceptual properties. We introduce the Structured Uncertainty Similarity Score (SUSS); it models each image through a set of perceptual components, each represented by a structured multivariate Normal distribution. These are trained in a generative, self-supervised manner to assign high likelihood to human-imperceptible augmentations. The final score is a weighted sum of component log-probabilities with weights learned from human perceptual datasets. Unlike feature-based methods, SUSS learns image-specific linear transformations of residuals in pixel space, enabling transparent inspection through decorrelated residuals and sampling. SUSS aligns closely with human perceptual judgments, shows strong perceptual calibration across diverse distortion types, and provides localized, interpretable explanations of its similarity assessments. We further demonstrate stable optimization behavior and competitive performance when using SUSS as a perceptual loss for downstream imaging tasks.

We propose a novel spectral generative modeling framework for natural language processing that jointly learns a global time varying Fourier dictionary and per token mixing coefficients, replacing the ubiquitous self attention mechanism in transformer architectures. By enforcing reconstruction losses in both the time domain (embedding reconstruction) and the frequency domain (via Short Time Fourier Transform magnitude matching) alongside a standard language modeling objective, and fitting a Gaussian Mixture Model (GMM) prior over the learned mixing vectors, our approach achieves competitive perplexity and generation quality on standard benchmarks such as WikiText2 and Penn Treebank. In contrast to the quadratic computation complexity of self attention, our method operates with linear complexity, delivering substantial efficiency gains. We demonstrate that spectral dictionary models can achieve competitive performance compared to transformer baselines while significantly reducing inference latency and memory footprint, offering a compelling alternative for scalable language modeling.

Supervised machine learning models boast remarkable predictive capabilities. But can you trust your model? Will it work in deployment? What else can it tell you about the world? We want models to be not only good, but interpretable. And yet the task of interpretation appears underspecified. Papers provide diverse and sometimes non-overlapping motivations for interpretability, and offer myriad notions of what attributes render models interpretable. Despite this ambiguity, many papers proclaim interpretability axiomatically, absent further explanation. In this paper, we seek to refine the discourse on interpretability. First, we examine the motivations underlying interest in interpretability, finding them to be diverse and occasionally discordant. Then, we address model properties and techniques thought to confer interpretability, identifying transparency to humans and post-hoc explanations as competing notions. Throughout, we discuss the feasibility and desirability of different notions, and question the oft-made assertions that linear models are interpretable and that deep neural networks are not.

Embeddings have become a pivotal means to represent complex, multi-faceted information about entities, concepts, and relationships in a condensed and useful format. Nevertheless, they often preclude direct interpretation. While downstream tasks make use of these compressed representations, meaningful interpretation usually requires visualization using dimensionality reduction or specialized machine learning interpretability methods. This paper addresses the challenge of making such embeddings more interpretable and broadly useful, by employing Large Language Models (LLMs) to directly interact with embeddings -- transforming abstract vectors into understandable narratives. By injecting embeddings into LLMs, we enable querying and exploration of complex embedding data. We demonstrate our approach on a variety of diverse tasks, including: enhancing concept activation vectors (CAVs), communicating novel embedded entities, and decoding user preferences in recommender systems. Our work couples the immense information potential of embeddings with the interpretative power of LLMs.

In this work we propose a simple and efficient framework for learning sentence representations from unlabelled data. Drawing inspiration from the distributional hypothesis and recent work on learning sentence representations, we reformulate the problem of predicting the context in which a sentence appears as a classification problem. Given a sentence and its context, a classifier distinguishes context sentences from other contrastive sentences based on their vector representations. This allows us to efficiently learn different types of encoding functions, and we show that the model learns high-quality sentence representations. We demonstrate that our sentence representations outperform state-of-the-art unsupervised and supervised representation learning methods on several downstream NLP tasks that involve understanding sentence semantics while achieving an order of magnitude speedup in training time.

Large language models (LLMs) have been widely deployed across numerous fields. Reinforcement Learning from Human Feedback (RLHF) leverages reward models (RMs) as proxies for human preferences to align LLM behaviors with human values, making the accuracy, reliability, and interpretability of RMs critical for effective alignment. However, traditional RMs lack interpretability, offer limited insight into the reasoning behind reward assignments, and are inflexible toward user preference shifts. While recent multidimensional RMs aim for improved interpretability, they often fail to provide feature-level attribution and require costly annotations. To overcome these limitations, we introduce the Sparse Autoencoder-enhanced Reward Model (SARM), a novel architecture that integrates a pretrained Sparse Autoencoder (SAE) into a reward model. SARM maps the hidden activations of LLM-based RM into an interpretable, sparse, and monosemantic feature space, from which a scalar head aggregates feature activations to produce transparent and conceptually meaningful reward scores. Empirical evaluations demonstrate that SARM facilitates direct feature-level attribution of reward assignments, allows dynamic adjustment to preference shifts, and achieves superior alignment performance compared to conventional reward models. Our code is available at https://github.com/schrieffer-z/sarm.

Reinforcement learning from human feedback (RLHF) has emerged as the primary method for aligning large language models (LLMs) with human preferences. The RLHF process typically starts by training a reward model (RM) using human preference data. Conventional RMs are trained on pairwise responses to the same user request, with relative ratings indicating which response humans prefer. The trained RM serves as a proxy for human preferences. However, due to the black-box nature of RMs, their outputs lack interpretability, as humans cannot intuitively understand why an RM thinks a response is good or not. As RMs act as human preference proxies, we believe they should be human-interpretable to ensure that their internal decision processes are consistent with human preferences and to prevent reward hacking in LLM alignment. To build RMs with interpretable preferences, we propose a two-stage approach: i) train an Absolute-Rating Multi-Objective Reward Model (ArmoRM) with multi-dimensional absolute-rating data, each dimension corresponding to a human-interpretable objective (e.g., honesty, verbosity, safety); ii) employ a Mixture-of-Experts (MoE) strategy with a gating network that automatically selects the most suitable reward objectives based on the context. We efficiently trained an ArmoRM with Llama-3 8B and a gating network consisting of a shallow MLP on top of the ArmoRM. Our trained model, ArmoRM-Llama3-8B, obtains state-of-the-art performance on RewardBench, a benchmark evaluating RMs for language modeling. Notably, the performance of our model surpasses the LLM-as-a-judge method with GPT-4 judges by a margin, and approaches the performance of the much larger Nemotron-4 340B reward model.

Deep learning methods are highly accurate, yet their opaque decision process prevents them from earning full human trust. Concept-based models aim to address this issue by learning tasks based on a set of human-understandable concepts. However, state-of-the-art concept-based models rely on high-dimensional concept embedding representations which lack a clear semantic meaning, thus questioning the interpretability of their decision process. To overcome this limitation, we propose the Deep Concept Reasoner (DCR), the first interpretable concept-based model that builds upon concept embeddings. In DCR, neural networks do not make task predictions directly, but they build syntactic rule structures using concept embeddings. DCR then executes these rules on meaningful concept truth degrees to provide a final interpretable and semantically-consistent prediction in a differentiable manner. Our experiments show that DCR: (i) improves up to +25% w.r.t. state-of-the-art interpretable concept-based models on challenging benchmarks (ii) discovers meaningful logic rules matching known ground truths even in the absence of concept supervision during training, and (iii), facilitates the generation of counterfactual examples providing the learnt rules as guidance.

As machine learning algorithms are increasingly applied to high impact yet high risk tasks, such as medical diagnosis or autonomous driving, it is critical that researchers can explain how such algorithms arrived at their predictions. In recent years, a number of image saliency methods have been developed to summarize where highly complex neural networks "look" in an image for evidence for their predictions. However, these techniques are limited by their heuristic nature and architectural constraints. In this paper, we make two main contributions: First, we propose a general framework for learning different kinds of explanations for any black box algorithm. Second, we specialise the framework to find the part of an image most responsible for a classifier decision. Unlike previous works, our method is model-agnostic and testable because it is grounded in explicit and interpretable image perturbations.

This work presents a novel reinforcement learning (RL) algorithm based on Y-wise Affine Neural Networks (YANNs). YANNs provide an interpretable neural network which can exactly represent known piecewise affine functions of arbitrary input and output dimensions defined on any amount of polytopic subdomains. One representative application of YANNs is to reformulate explicit solutions of multi-parametric linear model predictive control. Built on this, we propose the use of YANNs to initialize RL actor and critic networks, which enables the resulting YANN-RL control algorithm to start with the confidence of linear optimal control. The YANN-actor is initialized by representing the multi-parametric control solutions obtained via offline computation using an approximated linear system model. The YANN-critic represents the explicit form of the state-action value function for the linear system and the reward function as the objective in an optimal control problem (OCP). Additional network layers are injected to extend YANNs for nonlinear expressions, which can be trained online by directly interacting with the true complex nonlinear system. In this way, both the policy and state-value functions exactly represent a linear OCP initially and are able to eventually learn the solution of a general nonlinear OCP. Continuous policy improvement is also implemented to provide heuristic confidence that the linear OCP solution serves as an effective lower bound to the performance of RL policy. The YANN-RL algorithm is demonstrated on a clipped pendulum and a safety-critical chemical-reactive system. Our results show that YANN-RL significantly outperforms the modern RL algorithm using deep deterministic policy gradient, especially when considering safety constraints.

Deep learning models are increasingly employed for perception, prediction, and control in complex systems. Embedding physical knowledge into these models is crucial for achieving realistic and consistent outputs, a challenge often addressed by physics-informed machine learning. However, integrating physical knowledge with representation learning becomes difficult when dealing with high-dimensional observation data, such as images, particularly under conditions of incomplete or imprecise state information. To address this, we propose Physically Interpretable World Models, a novel architecture that aligns learned latent representations with real-world physical quantities. Our method combines a variational autoencoder with a dynamical model that incorporates unknown system parameters, enabling the discovery of physically meaningful representations. By employing weak supervision with interval-based constraints, our approach eliminates the reliance on ground-truth physical annotations. Experimental results demonstrate that our method improves the quality of learned representations while achieving accurate predictions of future states, advancing the field of representation learning in dynamic systems.

Although state-of-the-art classifiers for facial expression recognition (FER) can achieve a high level of accuracy, they lack interpretability, an important feature for end-users. Experts typically associate spatial action units (\aus) from a codebook to facial regions for the visual interpretation of expressions. In this paper, the same expert steps are followed. A new learning strategy is proposed to explicitly incorporate \au cues into classifier training, allowing to train deep interpretable models. During training, this \au codebook is used, along with the input image expression label, and facial landmarks, to construct a \au heatmap that indicates the most discriminative image regions of interest w.r.t the facial expression. This valuable spatial cue is leveraged to train a deep interpretable classifier for FER. This is achieved by constraining the spatial layer features of a classifier to be correlated with \au heatmaps. Using a composite loss, the classifier is trained to correctly classify an image while yielding interpretable visual layer-wise attention correlated with \au maps, simulating the expert decision process. Our strategy only relies on image class expression for supervision, without additional manual annotations. Our new strategy is generic, and can be applied to any deep CNN- or transformer-based classifier without requiring any architectural change or significant additional training time. Our extensive evaluation on two public benchmarks \rafdb, and \affectnet datasets shows that our proposed strategy can improve layer-wise interpretability without degrading classification performance. In addition, we explore a common type of interpretable classifiers that rely on class activation mapping (CAM) methods, and show that our approach can also improve CAM interpretability.

Deep learning models have achieved impressive prediction performance but often sacrifice interpretability, a critical consideration in high-stakes domains such as healthcare or policymaking. In contrast, generalized additive models (GAMs) can maintain interpretability but often suffer from poor prediction performance due to their inability to effectively capture feature interactions. In this work, we aim to bridge this gap by using pre-trained neural language models to extract embeddings for each input before learning a linear model in the embedding space. The final model (which we call Emb-GAM) is a transparent, linear function of its input features and feature interactions. Leveraging the language model allows Emb-GAM to learn far fewer linear coefficients, model larger interactions, and generalize well to novel inputs (e.g. unseen ngrams in text). Across a variety of natural-language-processing datasets, Emb-GAM achieves strong prediction performance without sacrificing interpretability. All code is made available on Github.

Deep learning models have achieved remarkable success in different areas of machine learning over the past decade; however, the size and complexity of these models make them difficult to understand. In an effort to make them more interpretable, several recent works focus on explaining parts of a deep neural network through human-interpretable, semantic attributes. However, it may be impossible to completely explain complex models using only semantic attributes. In this work, we propose to augment these attributes with a small set of uninterpretable features. Specifically, we develop a novel explanation framework ELUDE (Explanation via Labelled and Unlabelled DEcomposition) that decomposes a model's prediction into two parts: one that is explainable through a linear combination of the semantic attributes, and another that is dependent on the set of uninterpretable features. By identifying the latter, we are able to analyze the "unexplained" portion of the model, obtaining insights into the information used by the model. We show that the set of unlabelled features can generalize to multiple models trained with the same feature space and compare our work to two popular attribute-oriented methods, Interpretable Basis Decomposition and Concept Bottleneck, and discuss the additional insights ELUDE provides.

Drug discovery is a complex and resource-intensive process, making early prediction of approval outcomes critical for optimizing research investments. While classical machine learning and deep learning methods have shown promise in drug approval prediction, their limited interpretability constraints their impact. Here, we present DrugReasoner, a reasoning-based large language model (LLM) built on the LLaMA architecture and fine-tuned with group relative policy optimization (GRPO) to predict the likelihood of small-molecule approval. DrugReasoner integrates molecular descriptors with comparative reasoning against structurally similar approved and unapproved compounds, generating predictions alongside step-by-step rationales and confidence scores. DrugReasoner achieved robust performance with an AUC of 0.732 and an F1 score of 0.729 on the validation set and 0.725 and 0.718 on the test set, respectively. These results outperformed conventional baselines, including logistic regression, support vector machine, and k-nearest neighbors and had competitive performance relative to XGBoost. On an external independent dataset, DrugReasoner outperformed both baseline and the recently developed ChemAP model, achieving an AUC of 0.728 and an F1-score of 0.774, while maintaining high precision and balanced sensitivity, demonstrating robustness in real-world scenarios. These findings demonstrate that DrugReasoner not only delivers competitive predictive accuracy but also enhances transparency through its reasoning outputs, thereby addressing a key bottleneck in AI-assisted drug discovery. This study highlights the potential of reasoning-augmented LLMs as interpretable and effective tools for pharmaceutical decision-making.

Vision-language models (VLMs) have advanced reasoning in natural scenes, but their role in medical imaging remains underexplored. Medical reasoning tasks demand robust image analysis and well-justified answers, posing challenges due to the complexity of medical images. Transparency and trustworthiness are essential for clinical adoption and regulatory compliance. We introduce Med-R1, a framework exploring reinforcement learning (RL) to enhance VLMs' generalizability and trustworthiness in medical reasoning. Leveraging the DeepSeek strategy, we employ Group Relative Policy Optimization (GRPO) to guide reasoning paths via reward signals. Unlike supervised fine-tuning (SFT), which often overfits and lacks generalization, RL fosters robust and diverse reasoning. Med-R1 is evaluated across eight medical imaging modalities: CT, MRI, Ultrasound, Dermoscopy, Fundus Photography, Optical Coherence Tomography (OCT), Microscopy, and X-ray Imaging. Compared to its base model, Qwen2-VL-2B, Med-R1 achieves a 29.94% accuracy improvement and outperforms Qwen2-VL-72B, which has 36 times more parameters. Testing across five question types-modality recognition, anatomy identification, disease diagnosis, lesion grading, and biological attribute analysis Med-R1 demonstrates superior generalization, exceeding Qwen2-VL-2B by 32.06% and surpassing Qwen2-VL-72B in question-type generalization. These findings show that RL improves medical reasoning and enables parameter-efficient models to outperform significantly larger ones. With interpretable reasoning outputs, Med-R1 represents a promising step toward generalizable, trustworthy, and clinically viable medical VLMs.

Self-supervised learning has emerged as a highly effective approach in the fields of natural language processing and computer vision. It is also applicable to brain signals such as electroencephalography (EEG) data, given the abundance of available unlabeled data that exist in a wide spectrum of real-world medical applications ranging from seizure detection to wave analysis. The existing works leveraging self-supervised learning on EEG modeling mainly focus on pretraining upon each individual dataset corresponding to a single downstream task, which cannot leverage the power of abundant data, and they may derive sub-optimal solutions with a lack of generalization. Moreover, these methods rely on end-to-end model learning which is not easy for humans to understand. In this paper, we present a novel EEG foundation model, namely EEGFormer, pretrained on large-scale compound EEG data. The pretrained model cannot only learn universal representations on EEG signals with adaptable performance on various downstream tasks but also provide interpretable outcomes of the useful patterns within the data. To validate the effectiveness of our model, we extensively evaluate it on various downstream tasks and assess the performance under different transfer settings. Furthermore, we demonstrate how the learned model exhibits transferable anomaly detection performance and provides valuable interpretability of the acquired patterns via self-supervised learning.

While transformers achieve strong performance, their internal decision-making processes remain opaque. We investigate whether architectural constraints can enforce interpretability by design through architectural stream independence: maintaining a token stream (carrying symbolic structure) and contextual semantics in separated streams that remain independently observable throughout processing, with integration delayed until output. We validate this principle through the Late Fusion Architecture (LFA), which demonstrates interpretable symbolic heads through all the final layers, while standard transformers show dissolution by the third of six layers; we quantify this effect by introducing the Token-Position Dependence Score (PDS), with PDS_{max} = 0.276 and 0.058, respectively. Crucially, intervention experiments demonstrate functional modularity: suppressing LFA's recency heads causes minimal semantic damage (Cohen's d = -0.158) versus catastrophic entanglement in baselines (d = -0.672). LFA demonstrates that architectural constraints improve underlying learning mechanisms, averaging 42% stability versus 19% and 11% for baseline comparisons, with extremes from 50% on LFA's best pairs (6 of 12 heads position-invariant) down to 0% complete collapse in over-constrained cases. By preventing premature entanglement, architectural independence steers models toward semantic understanding over positional heuristics, establishing interpretability as an architectural design criterion enforceable through structural constraints rather than post-hoc analysis.

Deep learning based automated pathological diagnosis has markedly improved diagnostic efficiency and reduced variability between observers, yet its clinical adoption remains limited by opaque model decisions and a lack of traceable rationale. To address this, recent multimodal visual reasoning architectures provide a unified framework that generates segmentation masks at the pixel level alongside semantically aligned textual explanations. By localizing lesion regions and producing expert style diagnostic narratives, these models deliver the transparent and interpretable insights necessary for dependable AI assisted pathology. Building on these advancements, we propose PathMR, a cell-level Multimodal visual Reasoning framework for Pathological image analysis. Given a pathological image and a textual query, PathMR generates expert-level diagnostic explanations while simultaneously predicting cell distribution patterns. To benchmark its performance, we evaluated our approach on the publicly available PathGen dataset as well as on our newly developed GADVR dataset. Extensive experiments on these two datasets demonstrate that PathMR consistently outperforms state-of-the-art visual reasoning methods in text generation quality, segmentation accuracy, and cross-modal alignment. These results highlight the potential of PathMR for improving interpretability in AI-driven pathological diagnosis. The code will be publicly available in https://github.com/zhangye-zoe/PathMR.

Two common approaches to sequential decision-making are AI planning (AIP) and reinforcement learning (RL). Each has strengths and weaknesses. AIP is interpretable, easy to integrate with symbolic knowledge, and often efficient, but requires an up-front logical domain specification and is sensitive to noise; RL only requires specification of rewards and is robust to noise but is sample inefficient and not easily supplied with external knowledge. We propose an integrative approach that combines high-level planning with RL, retaining interpretability, transfer, and efficiency, while allowing for robust learning of the lower-level plan actions. Our approach defines options in hierarchical reinforcement learning (HRL) from AIP operators by establishing a correspondence between the state transition model of AI planning problem and the abstract state transition system of a Markov Decision Process (MDP). Options are learned by adding intrinsic rewards to encourage consistency between the MDP and AIP transition models. We demonstrate the benefit of our integrated approach by comparing the performance of RL and HRL algorithms in both MiniGrid and N-rooms environments, showing the advantage of our method over the existing ones.

Recently, language-guided global image editing draws increasing attention with growing application potentials. However, previous GAN-based methods are not only confined to domain-specific, low-resolution data but also lacking in interpretability. To overcome the collective difficulties, we develop a text-to-operation model to map the vague editing language request into a series of editing operations, e.g., change contrast, brightness, and saturation. Each operation is interpretable and differentiable. Furthermore, the only supervision in the task is the target image, which is insufficient for a stable training of sequential decisions. Hence, we propose a novel operation planning algorithm to generate possible editing sequences from the target image as pseudo ground truth. Comparison experiments on the newly collected MA5k-Req dataset and GIER dataset show the advantages of our methods. Code is available at https://jshi31.github.io/T2ONet.

Accurate classification of pediatric central nervous system tumors remains challenging due to histological complexity and limited training data. While pathology foundation models have advanced whole-slide image (WSI) analysis, they often fail to leverage the rich, complementary information found in clinical text and tissue microarchitecture. To this end, we propose PathMoE, an interpretable multimodal framework that integrates H\&E slides, pathology reports, and nuclei-level cell graphs via an interaction-aware mixture-of-experts architecture built on state-of-the-art foundation models for each modality. By training specialized experts to capture modality uniqueness, redundancy, and synergy, PathMoE employs an input-dependent gating mechanism that dynamically weights these interactions, providing sample-level interpretability. We evaluate our framework on two dataset-specific classification tasks on an internal pediatric brain tumor dataset (PBT) and external TCGA datasets. PathMoE improves macro-F1 from 0.762 to 0.799 (+0.037) on PBT when integrating WSI, text, and graph modalities; on TCGA, augmenting WSI with graph knowledge improves macro-F1 from 0.668 to 0.709 (+0.041). These results demonstrate significant performance gains over state-of-the-art image-only baselines while revealing the specific modality interactions driving individual predictions. This interpretability is particularly critical for rare tumor subtypes, where transparent model reasoning is essential for clinical trust and diagnostic validation.

Large language models (LLMs) are increasingly used as evaluators for natural language generation, applying human-defined rubrics to assess system outputs. However, human rubrics are often static and misaligned with how models internally represent language quality. We introduce GER-Eval (Generating Evaluation Rubrics for Evaluation) to investigate whether LLMs can design and apply their own evaluation rubrics. We evaluate the semantic coherence and scoring reliability of LLM-defined criteria and their alignment with human criteria. LLMs reliably generate interpretable and task-aware evaluation dimensions and apply them consistently within models, but their scoring reliability degrades in factual and knowledge-intensive settings. Closed-source models such as GPT-4o achieve higher agreement and cross-model generalization than open-weight models such as Llama. Our findings position evaluation as a learned linguistic capability of LLMs, consistent within models but fragmented across them, and call for new methods that jointly model human and LLM evaluative language to improve reliability and interpretability.

Chest X-ray imaging is crucial for diagnosing pulmonary and cardiac diseases, yet its interpretation demands extensive clinical experience and suffers from inter-observer variability. While deep learning models offer high diagnostic accuracy, their black-box nature hinders clinical adoption in high-stakes medical settings. To address this, we propose X-Ray-CoT (Chest X-Ray Chain-of-Thought), a novel framework leveraging Vision-Language Large Models (LVLMs) for intelligent chest X-ray diagnosis and interpretable report generation. X-Ray-CoT simulates human radiologists' "chain-of-thought" by first extracting multi-modal features and visual concepts, then employing an LLM-based component with a structured Chain-of-Thought prompting strategy to reason and produce detailed natural language diagnostic reports. Evaluated on the CORDA dataset, X-Ray-CoT achieves competitive quantitative performance, with a Balanced Accuracy of 80.52% and F1 score of 78.65% for disease diagnosis, slightly surpassing existing black-box models. Crucially, it uniquely generates high-quality, explainable reports, as validated by preliminary human evaluations. Our ablation studies confirm the integral role of each proposed component, highlighting the necessity of multi-modal fusion and CoT reasoning for robust and transparent medical AI. This work represents a significant step towards trustworthy and clinically actionable AI systems in medical imaging.

Handheld grippers are increasingly used to collect human demonstrations due to their ease of deployment and versatility. However, most existing designs lack tactile sensing, despite the critical role of tactile feedback in precise manipulation. We present a portable, lightweight gripper with integrated tactile sensors that enables synchronized collection of visual and tactile data in diverse, real-world, and in-the-wild settings. Building on this hardware, we propose a cross-modal representation learning framework that integrates visual and tactile signals while preserving their distinct characteristics. The learning procedure allows the emergence of interpretable representations that consistently focus on contacting regions relevant for physical interactions. When used for downstream manipulation tasks, these representations enable more efficient and effective policy learning, supporting precise robotic manipulation based on multimodal feedback. We validate our approach on fine-grained tasks such as test tube insertion and pipette-based fluid transfer, demonstrating improved accuracy and robustness under external disturbances. Our project page is available at https://binghao-huang.github.io/touch_in_the_wild/ .

Heart failure is a leading cause of global mortality, necessitating improved diagnostic strategies. Classical machine learning models struggle with challenges such as high-dimensional data, class imbalances, poor feature representations, and a lack of interpretability. While quantum machine learning holds promise, current hybrid models have not fully exploited quantum advantages. In this paper, we propose the Kolmogorov-Arnold Classical-Quantum Dual-Channel Neural Network (KACQ-DCNN), a novel hybrid architecture that replaces traditional multilayer perceptrons with Kolmogorov-Arnold Networks (KANs), enabling learnable univariate activation functions. Our KACQ-DCNN 4-qubit, 1-layer model outperforms 37 benchmark models, including 16 classical and 12 quantum neural networks, achieving an accuracy of 92.03%, with macro-average precision, recall, and F1 scores of 92.00%. It also achieved a ROC-AUC of 94.77%, surpassing other models by significant margins, as validated by paired t-tests with a significance threshold of 0.0056 (after Bonferroni correction). Ablation studies highlight the synergistic effect of classical-quantum integration, improving performance by about 2% over MLP variants. Additionally, LIME and SHAP explainability techniques enhance feature interpretability, while conformal prediction provides robust uncertainty quantification. Our results demonstrate that KACQ-DCNN improves cardiovascular diagnostics by combining high accuracy with interpretability and uncertainty quantification.

The current state-of-the-art in quadruped locomotion is able to produce a variety of complex motions. These methods either rely on switching between a discrete set of skills or learn a distribution across gaits using complex black-box models. Alternatively, we present Gaitor, which learns a disentangled and 2D representation across locomotion gaits. This learnt representation forms a planning space for closed-loop control delivering continuous gait transitions and perceptive terrain traversal. Gaitor's latent space is readily interpretable and we discover that during gait transitions, novel unseen gaits emerge. The latent space is disentangled with respect to footswing heights and lengths. This means that these gait characteristics can be varied independently in the 2D latent representation. Together with a simple terrain encoding and a learnt planner operating in the latent space, Gaitor can take motion commands including desired gait type and swing characteristics all while reacting to uneven terrain. We evaluate Gaitor in both simulation and the real world on the ANYmal C platform. To the best of our knowledge, this is the first work learning a unified and interpretable latent space for multiple gaits, resulting in continuous blending between different locomotion modes on a real quadruped robot. An overview of the methods and results in this paper is found at https://youtu.be/eVFQbRyilCA.

Reinforcement Learning is a highly active research field with promising advancements. In the field of autonomous driving, however, often very simple scenarios are being examined. Common approaches use non-interpretable control commands as the action space and unstructured reward designs which lack structure. In this work, we introduce Informed Reinforcement Learning, where a structured rulebook is integrated as a knowledge source. We learn trajectories and asses them with a situation-aware reward design, leading to a dynamic reward which allows the agent to learn situations which require controlled traffic rule exceptions. Our method is applicable to arbitrary RL models. We successfully demonstrate high completion rates of complex scenarios with recent model-based agents.

Purpose: Hard-to-interpret Black-box Machine Learning (ML) were often used for early Alzheimer's Disease (AD) detection. Methods: To interpret eXtreme Gradient Boosting (XGBoost), Random Forest (RF), and Support Vector Machine (SVM) black-box models a workflow based on Shapley values was developed. All models were trained on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset and evaluated for an independent ADNI test set, as well as the external Australian Imaging and Lifestyle flagship study of Ageing (AIBL), and Open Access Series of Imaging Studies (OASIS) datasets. Shapley values were compared to intuitively interpretable Decision Trees (DTs), and Logistic Regression (LR), as well as natural and permutation feature importances. To avoid the reduction of the explanation validity caused by correlated features, forward selection and aspect consolidation were implemented. Results: Some black-box models outperformed DTs and LR. The forward-selected features correspond to brain areas previously associated with AD. Shapley values identified biologically plausible associations with moderate to strong correlations with feature importances. The most important RF features to predict AD conversion were the volume of the amygdalae, and a cognitive test score. Good cognitive test performances and large brain volumes decreased the AD risk. The models trained using cognitive test scores significantly outperformed brain volumetric models (p<0.05). Cognitive Normal (CN) vs. AD models were successfully transferred to external datasets. Conclusion: In comparison to previous work, improved performances for ADNI and AIBL were achieved for CN vs. Mild Cognitive Impairment (MCI) classification using brain volumes. The Shapley values and the feature importances showed moderate to strong correlations.

Non-coding RNA structure and function are essential to understanding various biological processes, such as cell signaling, gene expression, and post-transcriptional regulations. These are all among the core problems in the RNA field. With the rapid growth of sequencing technology, we have accumulated a massive amount of unannotated RNA sequences. On the other hand, expensive experimental observatory results in only limited numbers of annotated data and 3D structures. Hence, it is still challenging to design computational methods for predicting their structures and functions. The lack of annotated data and systematic study causes inferior performance. To resolve the issue, we propose a novel RNA foundation model (RNA-FM) to take advantage of all the 23 million non-coding RNA sequences through self-supervised learning. Within this approach, we discover that the pre-trained RNA-FM could infer sequential and evolutionary information of non-coding RNAs without using any labels. Furthermore, we demonstrate RNA-FM's effectiveness by applying it to the downstream secondary/3D structure prediction, SARS-CoV-2 genome structure and evolution prediction, protein-RNA binding preference modeling, and gene expression regulation modeling. The comprehensive experiments show that the proposed method improves the RNA structural and functional modelling results significantly and consistently. Despite only being trained with unlabelled data, RNA-FM can serve as the foundational model for the field.

Geometry problem solving has attracted much attention in the NLP community recently. The task is challenging as it requires abstract problem understanding and symbolic reasoning with axiomatic knowledge. However, current datasets are either small in scale or not publicly available. Thus, we construct a new large-scale benchmark, Geometry3K, consisting of 3,002 geometry problems with dense annotation in formal language. We further propose a novel geometry solving approach with formal language and symbolic reasoning, called Interpretable Geometry Problem Solver (Inter-GPS). Inter-GPS first parses the problem text and diagram into formal language automatically via rule-based text parsing and neural object detecting, respectively. Unlike implicit learning in existing methods, Inter-GPS incorporates theorem knowledge as conditional rules and performs symbolic reasoning step by step. Also, a theorem predictor is designed to infer the theorem application sequence fed to the symbolic solver for the more efficient and reasonable searching path. Extensive experiments on the Geometry3K and GEOS datasets demonstrate that Inter-GPS achieves significant improvements over existing methods. The project with code and data is available at https://lupantech.github.io/inter-gps.