Daily Papers

Large language models (LLMs) have proven to work well in question-answering scenarios, but real-world applications often require access to tools for live information or actuation. For this, LLMs can be extended with tools, which are often defined in advance, also allowing for some fine-tuning for specific use cases. However, rapidly evolving software landscapes and individual services require the constant development and integration of new tools. Domain- or company-specific tools can greatly elevate the usefulness of an LLM, but such custom tools can be problematic to integrate, or the LLM may fail to reliably understand and use them. For this, we need strategies to define new tools and integrate them into the LLM dynamically, as well as robust and scalable zero-shot prompting methods that can make use of those tools in an efficient manner. In this paper, we present SAGE, a specialized conversational AI interface, based on the OPACA framework for tool discovery and execution. The integration with OPACA makes it easy to add new tools or services for the LLM to use, while SAGE itself presents rich extensibility and modularity. This not only provides the ability to seamlessly switch between different models (e.g. GPT, LLAMA), but also to add and select prompting methods, involving various setups of differently prompted agents for selecting and executing tools and evaluating the results. We implemented a number of task-solving strategies, making use of agentic concepts and prompting methods in various degrees of complexity, and evaluated those against a comprehensive set of benchmark services. The results are promising and highlight the distinct strengths and weaknesses of different task-solving strategies. Both SAGE and the OPACA framework, as well as the different benchmark services and results, are available as Open Source/Open Data on GitHub.

Vision-language models have demonstrated impressive capabilities as computer-use agents (CUAs) capable of automating diverse computer tasks. As their commercial potential grows, critical details of the most capable CUA systems remain closed. As these agents will increasingly mediate digital interactions and execute consequential decisions on our behalf, the research community needs access to open CUA frameworks to study their capabilities, limitations, and risks. To bridge this gap, we propose OpenCUA, a comprehensive open-source framework for scaling CUA data and foundation models. Our framework consists of: (1) an annotation infrastructure that seamlessly captures human computer-use demonstrations; (2) AgentNet, the first large-scale computer-use task dataset spanning 3 operating systems and 200+ applications and websites; (3) a scalable pipeline that transforms demonstrations into state-action pairs with reflective long Chain-of-Thought reasoning that sustain robust performance gains as data scales. Our end-to-end agent models demonstrate strong performance across CUA benchmarks. In particular, OpenCUA-32B achieves an average success rate of 34.8% on OSWorld-Verified, establishing a new state-of-the-art (SOTA) among open-source models and surpassing OpenAI CUA (GPT-4o). Further analysis confirms that our approach generalizes well across domains and benefits significantly from increased test-time computation. We release our annotation tool, datasets, code, and models to build open foundations for further CUA research.

Foundation models trained on large-scale dataset gain a recent surge in CV and NLP. In contrast, development in biomedical domain lags far behind due to data scarcity. To address this issue, we build and release PMC-OA, a biomedical dataset with 1.6M image-caption pairs collected from PubMedCentral's OpenAccess subset, which is 8 times larger than before. PMC-OA covers diverse modalities or diseases, with majority of the image-caption samples aligned at finer-grained level, i.e., subfigure and subcaption. While pretraining a CLIP-style model on PMC-OA, our model named PMC-CLIP achieves state-of-the-art results on various downstream tasks, including image-text retrieval on ROCO, MedMNIST image classification, Medical VQA, i.e. +8.1% R@10 on image-text retrieval, +3.9% accuracy on image classification.

Knee Osteoarthritis (KOA) is a highly prevalent chronic musculoskeletal condition with no currently available treatment. The manifestation of KOA is heterogeneous and prediction of its progression is challenging. Current literature suggests that the use of multi-modal data and advanced modeling methods, such as the ones based on Deep Learning, has promise in tackling this challenge. To date, however, the evidence on the efficacy of this approach is limited. In this study, we leveraged recent advances in Deep Learning and, using a Transformer approach, developed a unified framework for the multi-modal fusion of knee imaging data. Subsequently, we analyzed its performance across a range of scenarios by investigating multiple progression horizons -- from short-term to long-term. We report our findings using a large cohort (n=2421-3967) derived from the Osteoarthritis Initiative dataset. We show that structural knee MRI allows identifying radiographic KOA progressors on par with multi-modal fusion approaches, achieving an area under the ROC curve (ROC AUC) of 0.70-0.76 and Average Precision (AP) of 0.15-0.54 in 2-8 year horizons. Progression within 1 year was better predicted with a multi-modal method using X-ray, structural, and compositional MR images -- ROC AUC of 0.76(0.04), AP of 0.13(0.04) -- or via clinical data. Our follow-up analysis generally shows that prediction from the imaging data is more accurate for post-traumatic subjects, and we further investigate which subject subgroups may benefit the most. The present study provides novel insights into multi-modal imaging of KOA and brings a unified data-driven framework for studying its progression in an end-to-end manner, providing new tools for the design of more efficient clinical trials. The source code of our framework and the pre-trained models are made publicly available.

LiDAR-based SLAM is a core technology for autonomous vehicles and robots. One key contribution of this work to 3D LiDAR SLAM and localization is a fierce defense of view-based maps (pose graphs with time-stamped sensor readings) as the fundamental representation of maps. As will be shown, they allow for the greatest flexibility, enabling the posterior generation of arbitrary metric maps optimized for particular tasks, e.g. obstacle avoidance, real-time localization. Moreover, this work introduces a new framework in which mapping pipelines can be defined without coding, defining the connections of a network of reusable blocks much like deep-learning networks are designed by connecting layers of standardized elements. We also introduce tightly-coupled estimation of linear and angular velocity vectors within the Iterative Closest Point (ICP)-like optimizer, leading to superior robustness against aggressive motion profiles without the need for an IMU. Extensive experimental validation reveals that the proposal compares well to, or improves, former state-of-the-art (SOTA) LiDAR odometry systems, while also successfully mapping some hard sequences where others diverge. A proposed self-adaptive configuration has been used, without parameter changes, for all 3D LiDAR datasets with sensors between 16 and 128 rings, and has been extensively tested on 83 sequences over more than 250~km of automotive, hand-held, airborne, and quadruped LiDAR datasets, both indoors and outdoors. The system flexibility is demonstrated with additional configurations for 2D LiDARs and for building 3D NDT-like maps. The framework is open-sourced online: https://github.com/MOLAorg/mola

Data catalogs play a crucial role in modern data-driven organizations by facilitating the discovery, understanding, and utilization of diverse data assets. However, ensuring their quality and reliability is complex, especially in open and large-scale data environments. This paper proposes a framework to automatically determine the quality of open data catalogs, addressing the need for efficient and reliable quality assessment mechanisms. Our framework can analyze various core quality dimensions, such as accuracy, completeness, consistency, scalability, and timeliness, offer several alternatives for the assessment of compatibility and similarity across such catalogs as well as the implementation of a set of non-core quality dimensions such as provenance, readability, and licensing. The goal is to empower data-driven organizations to make informed decisions based on trustworthy and well-curated data assets. The source code that illustrates our approach can be downloaded from https://www.github.com/jorge-martinez-gil/dataq/.

The rapid advancement of ML models in critical sectors such as healthcare, finance, and security has intensified the need for robust data security, model integrity, and reliable outputs. Large multimodal foundational models, while crucial for complex tasks, present challenges in scalability, reliability, and potential misuse. Decentralized systems offer a solution by distributing workload and mitigating central points of failure, but they introduce risks of unauthorized access to sensitive data across nodes. We address these challenges with a comprehensive framework designed for responsible AI development. Our approach incorporates: 1) Zero-knowledge proofs for secure model verification, enhancing trust without compromising privacy. 2) Consensus-based verification checks to ensure consistent outputs across nodes, mitigating hallucinations and maintaining model integrity. 3) Split Learning techniques that segment models across different nodes, preserving data privacy by preventing full data access at any point. 4) Hardware-based security through trusted execution environments (TEEs) to protect data and computations. This framework aims to enhance security and privacy and improve the reliability and fairness of multimodal AI systems. Promoting efficient resource utilization contributes to more sustainable AI development. Our state-of-the-art proofs and principles demonstrate the framework's effectiveness in responsibly democratizing artificial intelligence, offering a promising approach for building secure and private foundational models.

In the current landscape of artificial intelligence, foundation models serve as the bedrock for advancements in both language and vision domains. OpenAI GPT-4 has emerged as the pinnacle in large language models (LLMs), while the computer vision (CV) domain boasts a plethora of state-of-the-art (SOTA) models such as Meta's SAM and DINO, and YOLOS. However, the financial and computational burdens of training new models from scratch remain a significant barrier to progress. In response to this challenge, we introduce UnifiedVisionGPT, a novel framework designed to consolidate and automate the integration of SOTA vision models, thereby facilitating the development of vision-oriented AI. UnifiedVisionGPT distinguishes itself through four key features: (1) provides a versatile multimodal framework adaptable to a wide range of applications, building upon the strengths of multimodal foundation models; (2) seamlessly integrates various SOTA vision models to create a comprehensive multimodal platform, capitalizing on the best components of each model; (3) prioritizes vision-oriented AI, ensuring a more rapid progression in the CV domain compared to the current trajectory of LLMs; and (4) introduces automation in the selection of SOTA vision models, generating optimal results based on diverse multimodal inputs such as text prompts and images. This paper outlines the architecture and capabilities of UnifiedVisionGPT, demonstrating its potential to revolutionize the field of computer vision through enhanced efficiency, versatility, generalization, and performance. Our implementation, along with the unified multimodal framework and comprehensive dataset, is made publicly available at https://github.com/LHBuilder/SA-Segment-Anything.

Medical diagnostic applications require models that can process multimodal medical inputs (images, patient histories, lab results) and generate diverse outputs including both textual reports and visual content (annotations, segmentation masks, and images). Despite this need, existing medical AI systems disrupt this unified process: medical image understanding models interpret images but cannot generate visual outputs, while medical image generation models synthesize images but cannot provide textual explanations. This leads to gaps in data representation, feature integration, and task-level multimodal capabilities. To this end, we propose a multi-level framework that draws inspiration from diagnostic workflows through the Observation-Knowledge-Analysis (OKA) paradigm. Specifically, at the observation level, we construct UniMed-5M, a dataset comprising over 5.6M samples that reformat diverse unimodal data into multimodal pairs for foundational observation. At the knowledge level, we propose Progressive Curriculum Learning that systematically introduces medical multimodal knowledge. At the analysis level, we introduce UniMedVL, the first medical unified multimodal model for the simultaneous analysis of image understanding and generation tasks within a single architecture. UniMedVL achieves superior performance on five medical image understanding benchmarks, while matching specialized models in generation quality across eight medical imaging modalities. Crucially, our unified architecture enables bidirectional knowledge sharing: generation tasks enhance visual understanding features, demonstrating that integrating traditionally separate capabilities within a single medical framework unlocks improvements across diverse medical vision-language tasks. Code is available at https://github.com/uni-medical/UniMedVL.

Color fundus photography and Optical Coherence Tomography (OCT) are the two most cost-effective tools for glaucoma screening. Both two modalities of images have prominent biomarkers to indicate glaucoma suspected. Clinically, it is often recommended to take both of the screenings for a more accurate and reliable diagnosis. However, although numerous algorithms are proposed based on fundus images or OCT volumes in computer-aided diagnosis, there are still few methods leveraging both of the modalities for the glaucoma assessment. Inspired by the success of Retinal Fundus Glaucoma Challenge (REFUGE) we held previously, we set up the Glaucoma grAding from Multi-Modality imAges (GAMMA) Challenge to encourage the development of fundus \& OCT-based glaucoma grading. The primary task of the challenge is to grade glaucoma from both the 2D fundus images and 3D OCT scanning volumes. As part of GAMMA, we have publicly released a glaucoma annotated dataset with both 2D fundus color photography and 3D OCT volumes, which is the first multi-modality dataset for glaucoma grading. In addition, an evaluation framework is also established to evaluate the performance of the submitted methods. During the challenge, 1272 results were submitted, and finally, top-10 teams were selected to the final stage. We analysis their results and summarize their methods in the paper. Since all these teams submitted their source code in the challenge, a detailed ablation study is also conducted to verify the effectiveness of the particular modules proposed. We find many of the proposed techniques are practical for the clinical diagnosis of glaucoma. As the first in-depth study of fundus \& OCT multi-modality glaucoma grading, we believe the GAMMA Challenge will be an essential starting point for future research.

Generative AI (GAI) offers unprecedented opportunities for research and innovation, but its commercialization has raised concerns about transparency, reproducibility, and safety. Many open GAI models lack the necessary components for full understanding and reproducibility, and some use restrictive licenses whilst claiming to be ``open-source''. To address these concerns, we propose the Model Openness Framework (MOF), a ranked classification system that rates machine learning models based on their completeness and openness, following principles of open science, open source, open data, and open access. The MOF requires specific components of the model development lifecycle to be included and released under appropriate open licenses. This framework aims to prevent misrepresentation of models claiming to be open, guide researchers and developers in providing all model components under permissive licenses, and help individuals and organizations identify models that can be safely adopted without restrictions. By promoting transparency and reproducibility, the MOF combats ``openwashing'' practices and establishes completeness and openness as primary criteria alongside the core tenets of responsible AI. Wide adoption of the MOF will foster a more open AI ecosystem, benefiting research, innovation, and adoption of state-of-the-art models.

Optical coherence tomography angiography (OCTA) is a novel imaging modality that has been widely utilized in ophthalmology and neuroscience studies to observe retinal vessels and microvascular systems. However, publicly available OCTA datasets remain scarce. In this paper, we introduce the largest and most comprehensive OCTA dataset dubbed OCTA-500, which contains OCTA imaging under two fields of view (FOVs) from 500 subjects. The dataset provides rich images and annotations including two modalities (OCT/OCTA volumes), six types of projections, four types of text labels (age / gender / eye / disease) and seven types of segmentation labels (large vessel/capillary/artery/vein/2D FAZ/3D FAZ/retinal layers). Then, we propose a multi-object segmentation task called CAVF, which integrates capillary segmentation, artery segmentation, vein segmentation, and FAZ segmentation under a unified framework. In addition, we optimize the 3D-to-2D image projection network (IPN) to IPN-V2 to serve as one of the segmentation baselines. Experimental results demonstrate that IPN-V2 achieves an ~10% mIoU improvement over IPN on CAVF task. Finally, we further study the impact of several dataset characteristics: the training set size, the model input (OCT/OCTA, 3D volume/2D projection), the baseline networks, and the diseases. The dataset and code are publicly available at: https://ieee-dataport.org/open-access/octa-500.

KonfAI is a modular, extensible, and fully configurable deep learning framework specifically designed for medical imaging tasks. It enables users to define complete training, inference, and evaluation workflows through structured YAML configuration files, without modifying the underlying code. This declarative approach enhances reproducibility, transparency, and experimental traceability while reducing development time. Beyond the capabilities of standard pipelines, KonfAI provides native abstractions for advanced strategies including patch-based learning, test-time augmentation, model ensembling, and direct access to intermediate feature representations for deep supervision. It also supports complex multi-model training setups such as generative adversarial architectures. Thanks to its modular and extensible architecture, KonfAI can easily accommodate custom models, loss functions, and data processing components. The framework has been successfully applied to segmentation, registration, and image synthesis tasks, and has contributed to top-ranking results in several international medical imaging challenges. KonfAI is open source and available at https://github.com/vboussot/KonfAI{https://github.com/vboussot/KonfAI}.

Biomedical multimodal assistants have the potential to unify radiology, pathology, and clinical-text reasoning, yet a critical deployment gap remains: top-performing systems are either closed-source or computationally prohibitive, precluding the on-premises deployment required for patient privacy and PHI compliance. We introduce MEDGPT-OSS, an open-weight, 20B-parameter generalist vision-language model designed to facilitate open research in clinical AI. Rather than relying on architectural complexity, MEDGPT-OSS pairs the GPT-oss language backbone with a visual front-end via a optimized, three-stage training curriculum. By progressively domain-adapting these modules through rigorous data curation and long-context multimodal alignment, we demonstrate that a 20B model can bridge the capacity gap. It successfully outperforms larger open medical models on out-of-distribution (OOD) multimodal reasoning and complex text-only clinical tasks. By unifying diverse modalities under a single instruction-following interface, MEDGPT-OSS maintains a parameter-efficient footprint fully compatible with commodity GPUs. We release the complete training recipe, open-weight checkpoints, and a rigorous evaluation harness to serve as a verifiable foundation for privacy-preserving, institution-specific clinical AI research.

OpenAI's CLIP, released in early 2021, have long been the go-to choice of vision encoder for building multimodal foundation models. Although recent alternatives such as SigLIP have begun to challenge this status quo, to our knowledge none are fully open: their training data remains proprietary and/or their training recipes are not released. This paper fills this gap with OpenVision, a fully-open, cost-effective family of vision encoders that match or surpass the performance of OpenAI's CLIP when integrated into multimodal frameworks like LLaVA. OpenVision builds on existing works -- e.g., CLIPS for training framework and Recap-DataComp-1B for training data -- while revealing multiple key insights in enhancing encoder quality and showcasing practical benefits in advancing multimodal models. By releasing vision encoders spanning from 5.9M to 632.1M parameters, OpenVision offers practitioners a flexible trade-off between capacity and efficiency in building multimodal models: larger models deliver enhanced multimodal performance, while smaller versions enable lightweight, edge-ready multimodal deployments.

Despite increasing discussions on open-source Artificial Intelligence (AI), existing research lacks a discussion on the transparency and accessibility of state-of-the-art (SoTA) Large Language Models (LLMs). The Open Source Initiative (OSI) has recently released its first formal definition of open-source software. This definition, when combined with standard dictionary definitions and the sparse published literature, provide an initial framework to support broader accessibility to AI models such as LLMs, but more work is essential to capture the unique dynamics of openness in AI. In addition, concerns about open-washing, where models claim openness but lack full transparency, has been raised, which limits the reproducibility, bias mitigation, and domain adaptation of these models. In this context, our study critically analyzes SoTA LLMs from the last five years, including ChatGPT, DeepSeek, LLaMA, and others, to assess their adherence to transparency standards and the implications of partial openness. Specifically, we examine transparency and accessibility from two perspectives: open-source vs. open-weight models. Our findings reveal that while some models are labeled as open-source, this does not necessarily mean they are fully open-sourced. Even in the best cases, open-source models often do not report model training data, and code as well as key metrics, such as weight accessibility, and carbon emissions. To the best of our knowledge, this is the first study that systematically examines the transparency and accessibility of over 100 different SoTA LLMs through the dual lens of open-source and open-weight models. The findings open avenues for further research and call for responsible and sustainable AI practices to ensure greater transparency, accountability, and ethical deployment of these models.(DeepSeek transparency, ChatGPT accessibility, open source, DeepSeek open source)

In this work, we pursue a unified paradigm for multimodal pretraining to break the scaffolds of complex task/modality-specific customization. We propose OFA, a Task-Agnostic and Modality-Agnostic framework that supports Task Comprehensiveness. OFA unifies a diverse set of cross-modal and unimodal tasks, including image generation, visual grounding, image captioning, image classification, language modeling, etc., in a simple sequence-to-sequence learning framework. OFA follows the instruction-based learning in both pretraining and finetuning stages, requiring no extra task-specific layers for downstream tasks. In comparison with the recent state-of-the-art vision & language models that rely on extremely large cross-modal datasets, OFA is pretrained on only 20M publicly available image-text pairs. Despite its simplicity and relatively small-scale training data, OFA achieves new SOTAs in a series of cross-modal tasks while attaining highly competitive performances on uni-modal tasks. Our further analysis indicates that OFA can also effectively transfer to unseen tasks and unseen domains. Our code and models are publicly available at https://github.com/OFA-Sys/OFA.

In ophthalmic surgery, developing an AI system capable of interpreting surgical videos and predicting subsequent operations requires numerous ophthalmic surgical videos with high-quality annotations, which are difficult to collect due to privacy concerns and labor consumption. Text-guided video generation (T2V) emerges as a promising solution to overcome this issue by generating ophthalmic surgical videos based on surgeon instructions. In this paper, we present Ophora, a pioneering model that can generate ophthalmic surgical videos following natural language instructions. To construct Ophora, we first propose a Comprehensive Data Curation pipeline to convert narrative ophthalmic surgical videos into a large-scale, high-quality dataset comprising over 160K video-instruction pairs, Ophora-160K. Then, we propose a Progressive Video-Instruction Tuning scheme to transfer rich spatial-temporal knowledge from a T2V model pre-trained on natural video-text datasets for privacy-preserved ophthalmic surgical video generation based on Ophora-160K. Experiments on video quality evaluation via quantitative analysis and ophthalmologist feedback demonstrate that Ophora can generate realistic and reliable ophthalmic surgical videos based on surgeon instructions. We also validate the capability of Ophora for empowering downstream tasks of ophthalmic surgical workflow understanding. Code is available at https://github.com/mar-cry/Ophora.

The development of speech foundation models (SFMs) like Whisper and SeamlessM4T has significantly advanced the field of speech processing. However, their closed nature--with inaccessible training data and code--poses major reproducibility and fair evaluation challenges. While other domains have made substantial progress toward open science by developing fully transparent models trained on open-source (OS) code and data, similar efforts in speech remain limited. To fill this gap, we introduce FAMA, the first family of open science SFMs for English and Italian, trained on 150k+ hours of OS speech data. Moreover, we present a new dataset containing 16k hours of cleaned and pseudo-labeled speech for both languages. Results show that FAMA achieves competitive performance compared to existing SFMs while being up to 8 times faster. All artifacts, including code, datasets, and models, are released under OS-compliant licenses, promoting openness in speech technology research.

In this technical report, we introduce OpenR, an open-source framework designed to integrate key components for enhancing the reasoning capabilities of large language models (LLMs). OpenR unifies data acquisition, reinforcement learning training (both online and offline), and non-autoregressive decoding into a cohesive software platform. Our goal is to establish an open-source platform and community to accelerate the development of LLM reasoning. Inspired by the success of OpenAI's o1 model, which demonstrated improved reasoning abilities through step-by-step reasoning and reinforcement learning, OpenR integrates test-time compute, reinforcement learning, and process supervision to improve reasoning in LLMs. Our work is the first to provide an open-source framework that explores the core techniques of OpenAI's o1 model with reinforcement learning, achieving advanced reasoning capabilities beyond traditional autoregressive methods. We demonstrate the efficacy of OpenR by evaluating it on the MATH dataset, utilising publicly available data and search methods. Our initial experiments confirm substantial gains, with relative improvements in reasoning and performance driven by test-time computation and reinforcement learning through process reward models. The OpenR framework, including code, models, and datasets, is accessible at https://openreasoner.github.io.