Text Classification
Transformers
English
bert
biology
genomics
dna
variant-effect-prediction
dnabert
deepvregulome
transcription-factors
histone-modifications
ENCODE
chip-seq
regulatory-variants
cancer-genomics
glioblastoma
noncoding-variants
fine-tuned
sequence-classification
Eval Results (legacy)
Instructions to use duttaprat/DeepVRegulome with libraries, inference providers, notebooks, and local apps. Follow these links to get started.
- Libraries
- Transformers
How to use duttaprat/DeepVRegulome with Transformers:
# Use a pipeline as a high-level helper from transformers import pipeline pipe = pipeline("text-classification", model="duttaprat/DeepVRegulome")# Load model directly from transformers import AutoTokenizer, AutoModelForSequenceClassification tokenizer = AutoTokenizer.from_pretrained("duttaprat/DeepVRegulome") model = AutoModelForSequenceClassification.from_pretrained("duttaprat/DeepVRegulome", device_map="auto") - Notebooks
- Google Colab
- Kaggle
updated
Browse files
README.md
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# DeepVRegulome
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DeepVRegulome is an end-to-end framework for predicting the functional impact
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of small somatic variants in non-coding regulatory regions using fine-tuned
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[DNABERT](https://github.com/jerryji1993/DNABERT) models. It covers **458
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transcription factors**
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| Resource | Link |
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| Code | [GitHub: DavuluriLab/DeepVRegulome](https://github.com/DavuluriLab/DeepVRegulome) |
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| PyPI | `pip install deepvregulome` |
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| Web App | [deepvregulome.streamlit.app](https://deepvregulome.streamlit.app) |
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## Key Features
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- **Variant effect scoring** via log-odds ratio between reference and alternate alleles
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- **Attention-based motif analysis** for interpretable predictions
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- **Experimentally validated** against SNP-SELEX (Yan et al., 2021, Nature Genetics): mean per-TF AUROC = 0.611 across 61 evaluable TFs
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# DeepVRegulome
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<p align="center">
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<a href="https://github.com/DavuluriLab/DeepVRegulome"><img src="https://img.shields.io/badge/GitHub-Repo-181717?logo=github" alt="GitHub"></a>
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<a href="https://pypi.org/project/deepvregulome/"><img src="https://img.shields.io/pypi/v/deepvregulome?color=blue" alt="PyPI"></a>
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<a href="https://pepy.tech/projects/deepvregulome"><img src="https://static.pepy.tech/personalized-badge/deepvregulome?period=total&units=INTERNATIONAL_SYSTEM&left_color=BLACK&right_color=GREEN&left_text=downloads" alt="PyPI Downloads"></a>
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<a href="https://huggingface.co/spaces/duttaprat/DeepVRegulome"><img src="https://img.shields.io/badge/%F0%9F%A4%97-Live%20Demo-blue" alt="HuggingFace Space"></a>
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<a href="https://arxiv.org/abs/2511.09026"><img src="https://img.shields.io/badge/arXiv-2511.09026-b31b1b" alt="arXiv"></a>
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<a href="https://deepvregulome.streamlit.app"><img src="https://img.shields.io/badge/demo-Streamlit-ff4b4b" alt="Streamlit"></a>
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<a href="https://creativecommons.org/licenses/by-nc/4.0/"><img src="https://img.shields.io/badge/license-CC--BY--NC--4.0-green" alt="License"></a>
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</p>
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**464 fine-tuned DNABERT models for regulatory variant effect prediction**
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DeepVRegulome is an end-to-end framework for predicting the functional impact
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of small somatic variants in non-coding regulatory regions using fine-tuned
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[DNABERT](https://github.com/jerryji1993/DNABERT) models. It covers **458
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transcription factors**, **4 histone modifications**, and **2 splice sites**
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(acceptor + donor) from ENCODE ChIP-seq and GENCODE data, validated against
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Yan et al. (2021) SNP-SELEX experimental variant-effect measurements.
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| Resource | Link |
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|----------|------|
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| Code | [GitHub: DavuluriLab/DeepVRegulome](https://github.com/DavuluriLab/DeepVRegulome) |
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| PyPI | `pip install deepvregulome` |
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| Web App | [deepvregulome.streamlit.app](https://deepvregulome.streamlit.app) |
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| Live Demo | [HuggingFace Space](https://huggingface.co/spaces/duttaprat/DeepVRegulome) |
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## Key Features
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- **464 fine-tuned models** (458 TF-binding + 4 histone mark + 2 splice-site) trained on ENCODE ChIP-seq peaks and GENCODE exon-intron junctions
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- **Splice-site disruption scoring** for acceptor (3') and donor (5') junction variants
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- **Variant effect scoring** via log-odds ratio between reference and alternate alleles
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- **Attention-based motif analysis** for interpretable predictions
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- **Experimentally validated** against SNP-SELEX (Yan et al., 2021, Nature Genetics): mean per-TF AUROC = 0.611 across 61 evaluable TFs
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