Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Sordariomycetes Sordariomycetidae Sordariales Chaetomiaceae Humicola

Fuscoatroside biosynthesis cluster protein F

Terpene cyclase-glycosyl transferase fusion protein; part of the gene cluster that mediates the biosynthesis of the enfumafungin-type antibiotic, fuscoatroside (PubMed:38654452). Within the pathway, fsoF catalyzes the acetylation of C2-alpha-OH following the C2 hydroxylation by the cytochrome monooxygenase fsoD (PubMed:38654452). The fuscoatroside biosynthesis is initiated by the cyclization of 2,3(S)-oxidosqualene through FsoA's terpene cyclase (TC) domain, leading to the formation of the fernane skeleton isomotiol, harboring a fernane triterpene skeleton with a C8-C9 double bond. Subsequently, C2-alpha-hydroxylation mediated by fsoD results in the production of 2-alpha-hydroxy-isomotiol, which is further acetylated by fsoF. The glycosyltransferase (GT) domain of FsoA may convert isomotiol, 2-alpha-hydroxy-isomotiol, and the acetylated derivative of 2-alpha-hydroxy-isomotiol into their corresponding glycosides 3-O-(beta-D-glucopyranosyl)-isomotiol, 3-O-(beta-D-glucopyranosyl)-2-alpha-hydroxy-isomotiol, and 3-O-(beta-D-glucopyranosyl)-2-alpha-acetoxy-isomotiol, which then undergo oxidative cleavage under the action of fsoE to form s 2-deacetoxy-fuscoatroside, 2-deacetyl-fuscoatroside, and fuscoatroside, respectively. Although hydroxylation followed by acetylation of 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside by fsoD and fsoF could not be ruled out, this process is likely to occur with difficulty due to bulky steric hindrance caused by the presence of a glycan at C3 in these compounds. Interestingly, fsoE can also utilize the aglycones isomotiol and 2-alpha-hydroxy-isomotiol as substrates to generate 19-beta-hydroxy-isomotiol and 2-alpha,19-beta-dihydroxy-isomotiol, respectively. These reactions occur with lower efficiency. Finally, fsoE can further convert 2-alpha,19-beta-dihydroxy-isomotiol into 2-alpha-hydroxy-ismotiol-19-one and 2-alpha-hydroxy-ismotiol-19-one into 2-deacetyl-3-deglucopyranosyl-fuscoatroside (PubMed:38654452)

3-O-(beta-D-glucopyranosyl)-2alpha-hydroxyisomotiol + acetyl-CoA = 3-O-(beta-D-glucopyranosyl)-2alpha-acetoxyisomotiol + CoA

2-deacetylfuscoatroside + acetyl-CoA = fuscoatroside + CoA

Secondary metabolite biosynthesis; terpenoid biosynthesis

Fuscoatroside and some of its derivatives show interesting antifungal activity against Candida albicans and Aspergillus niger

Acetyltransferase fsoF

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

N-linked (GlcNAc...) asparagine

N-linked (GlcNAc...) asparagine

N-linked (GlcNAc...) asparagine

Cao Z.Q.
Wang G.Q.
Luo R.
Gao Y.H.
Lv J.M.
Qin S.Y.
Chen G.D.
Awakawa T.
Bao X.F.
Mei Q.H.
Yao X.S.
Hu D.
Abe I.
Gao H.

Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C-C Bond Cleavage.

NUCLEOTIDE SEQUENCE [GENOMIC DNA]
FUNCTION
CATALYTIC ACTIVITY
PATHWAY
BIOTECHNOLOGY


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Disordered

Polar residues

Gly residues

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

Neonatal crystallizable Fc receptor splice variant 5

MHC class I-like antigen recognition-like

Disordered

Low complexity

Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Cyprinidae Schizothoracinae Schizothorax

Disordered

Polar residues

Alexander C.
Manchi R.
Akhtar M.S.
Kamalam B.S.
Tripathi P.H.
Sharma P.

F:insulin-like growth factor receptor binding

P:insulin-like growth factor receptor signaling pathway

P:negative regulation of apoptotic process

P:positive regulation of cell population proliferation

P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction


Eukaryota Discoba Euglenozoa Kinetoplastea Metakinetoplastina Trypanosomatida Trypanosomatidae Blastocrithidia

Helical

Helical

Helical

Helical

Helical

Helical

C:proton-transporting ATP synthase complex

F:proton transmembrane transporter activity

P:proton motive force-driven ATP synthesis


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family

Lacks conserved residue(s) required for the propagation of feature annotation

CUB

Myosin motor

FERM

Actin-binding

Disordered

Disordered

Disordered

Disordered

Pro residues

Low complexity

Polar residues

Low complexity

Pro residues

Pro residues

Polar residues

C:plasma membrane bounded cell projection

Myosin VI head, motor domain, U50 subdomain

Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Helical

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Curculionidae Curculioninae Anthonomini Anthonomus

Segura Leon O.L.
Lechuga-Paredes P.
Cibrian Tovar J.
Torres Huerta B.

Lechuga-Paredes P.
Segura-Leon O.L.
Cibrian-Tovar J.
Torres-Huerta B.
Velazquez-Gonzalez J.C.
Cruz-Jaramillo J.L.

Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Brassiceae Brassica

Yamamoto M.
Ishii T.
Ogura M.
Akanuma T.
Zhu X.
Kitashiba H.

Updating of a comprehensive list of S haplotypes of Brassica rapa, Brassica oleracea and Raphanus sativus.


Helical

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Peptidase S1

Disordered

Basic and acidic residues


PPR

PPR

PPR

PPR

Peptidase S26

Disordered

Gly residues


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Caridea Palaemonoidea Palaemonidae Macrobrachium

Belongs to the Toll-like receptor family

Helical

TIR

Disordered

Low complexity

Pro residues

Regulation of AMPs expression by Six Tolls in stomach during WSSV infection in Macrobrachium nipponense.

Toll/interleukin-1 receptor homology (TIR) domain


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Dendrobranchiata Penaeoidea Penaeidae Penaeus

Naveenkumar R.
Panigrahi A.
Bedekar M.
Saranya C.


Eukaryota Metazoa Spiralia Lophotrochozoa Nemertea Palaeonemertea Tubulaniformes Tubulanidae Tubulanus

BHLH

PAS

PAS

Disordered

Disordered

Basic and acidic residues

Basic and acidic residues

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1

hypoxia-inducible factor 3-alpha isoform X1

HLH, helix-loop-helix DNA-binding domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Caelifera Acrididea Acridomorpha Acridoidea Acrididae Oedipodinae Locusta

Tudor

Disordered

Polar residues

Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.


Disordered


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Aleyrodoidea Aleyrodidae Aleyrodinae Bemisia

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family

Peptidoglycan recognition protein family


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the G-protein coupled receptor 3 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 3 profile

Disordered

Polar residues

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).


Ig-like

Ig-like

Ig-like

Protein kinase

Ig-like

F:transmembrane receptor protein tyrosine kinase activity

P:cell surface receptor protein tyrosine kinase signaling pathway

TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR


Lacks conserved residue(s) required for the propagation of feature annotation

Helical

Helical

Helical

Helical

Helical


Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 1 profile

Rhodopsin 7-helix transmembrane proteins

Family A G protein-coupled receptor-like


F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Echiura Xenopneusta Urechidae Urechis

Heat shock protein family A member 12 variant X10

Belongs to the heat shock protein 70 family

F:ATP-dependent protein folding chaperone


Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily

Helical

Helical

Helical

Helical

Helical

Helical

Helical

G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN

NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


Helical

F:transmembrane receptor protein tyrosine kinase activator activity


Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Disordered

Disordered

Disordered

Polar residues

Basic residues

Polar residues

Polar residues

Low complexity

ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Characiformes Characoidei Acestrorhamphidae Acestrorhamphinae Astyanax

Molecular and hormonal mechanisms underlying oocyte maturation and ovulation and its application to seed production in the lambari (Astyanax altiparanae).

Hydroxysteroid (17-beta) dehydrogenase 3

20BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2


Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway

Helical

Helical

Helical

Helical

Helical

Helical

F:thyrotropin-releasing hormone receptor activity


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Liliopsida Arecaceae Calamoideae Calameae Salaccinae Salacca


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1

Protein modification; protein ubiquitination

Part of a SCF (SKP1-cullin-F-box) protein ligase complex

Helical

SKP1 component POZ

SKP1 component dimerisation

Disordered

Disordered

Basic residues

P:jasmonic acid mediated signaling pathway

P:ubiquitin-dependent protein catabolic process


IGFBP N-terminal


Heat shock protein family A member 12 variant X8

Belongs to the heat shock protein 70 family

F:ATP-dependent protein folding chaperone


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Lacks conserved residue(s) required for the propagation of feature annotation

Metalloendopeptidase

Peptidase M12A

DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING

Metalloproteases ('zincins'), catalytic domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Amphipyrinae Spodoptera

DM

DM

Disordered

Pro residues

Nagamine K.
Kanno Y.
Sahara K.
Fukushi M.
Ishikawa Y.
Terao M.
Kageyama D.
Shintani Y.

A novel segmented RNA virus that induces male killing in a noctuid moth.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA helicase RuvA subunit, C-terminal domain

DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT

Cysteine-rich DNA binding domain, (DM domain)


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

Tudor

Tudor

Tudor

Tudor

Kostyuchenko R.P.
Nikanorova D.D.
Amosov A.V.

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Ionotropic glutamate receptor C-terminal

F:ligand-gated monoatomic ion channel activity

P:detection of stimulus involved in sensory perception


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Ranunculales Papaveraceae Fumarioideae Corydalis

Helical

Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

P:isoquinoline alkaloid biosynthetic process


Eukaryota Viridiplantae Streptophyta Embryophyta Bryophyta Bryophytina Bryopsida Dicranidae Pottiales Pottiaceae Syntrichia

Belongs to the AP2/ERF transcription factor family. ERF subfamily

Disordered

Disordered

Basic and acidic residues

Low complexity

Basic and acidic residues

Low complexity

Polar residues

Low complexity

Silva A.T.
Gao B.
Fisher K.M.
Mishler B.D.
Ekwealor J.T.B.
Stark L.R.
Li X.
Zhang D.
Bowker M.A.
Brinda J.C.
Coe K.K.
Oliver M.J.

To dry perchance to live: Insights from the genome of the desiccation-tolerant biocrust moss Syntrichia caninervis.

F:DNA-binding transcription factor activity

Ethylene-responsive transcription factor 2

DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2C

DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2D


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Secretory carrier-associated membrane protein

Disordered

Pro residues

International Human Genome Sequencing Consortium

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Finishing the euchromatic sequence of the human genome.

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.

SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 3

SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Terebellida Terebelliformia Melinnidae Melinna

BHLH

PAS

PAS

Disordered

Basic residues

Basic and acidic residues

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1

HLH, helix-loop-helix DNA-binding domain


Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.


Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta

Calx-beta


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Portunoidea Portunidae Portuninae Scylla

Adipokinetic hormone/corazonin-related peptide promotes ovarian development in the mud crab, Scylla paramamosain.


Regulation of cellular response to hypoxia

Disordered

Basic residues

P:positive regulation of transcription by RNA polymerase II

COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77

COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 2-RELATED


RRM

Disordered

CUGBP Elav-like family member 1 isoform 2


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Caelifera Acrididea Acridomorpha Acridoidea Acrididae Oedipodinae Locusta

Tudor

Disordered

Polar residues


Tudor

Tudor


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Glutamate receptor ionotropic kainate-3 like protein

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Receptor ligand binding region

F:ligand-gated monoatomic ion channel activity


Tudor

Disordered

Low complexity


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Hirudinea Hirudinida Hirudiniformes Hirudinidae Hirudo

Peptidase M13 N-terminal domain-containing protein

Peptidase M13 N-terminal

Metalloproteases ('zincins'), catalytic domain


Eukaryota Metazoa Spiralia Lophotrochozoa Platyhelminthes Rhabditophora Seriata Tricladida Continenticola Geoplanoidea Dugesiidae Girardia

Helical

Helical

Helical

Helical

Helical

Morphometric characteristics of serotonergic nervous system, functional activity and the pathway in Girardia tigrina (Turbellaria, Platyhelminthes).

Rhodopsin 7-helix transmembrane proteins

ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR

Family A G protein-coupled receptor-like


Eukaryota Metazoa Cnidaria Anthozoa Hexacorallia Actiniaria Nynantheae Metridiidae Metridium

Solution structure of Metridium senile toxin Ms13-1 with the unique fold.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.

Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Maruca

axial binding residue

C18 oxylipin, EpOME, mediates the immune resolution at late infection stage in the legume pod borer, Maruca vitrata.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

P:C21-steroid hormone biosynthetic process

P:cellular response to peptide hormone stimulus

CYTOCHROME P450 FAMILY 24 SUBFAMILY A MEMBER 1


glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)

Belongs to the UDP-glycosyltransferase family


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Pinopsida
Pinidae
Conifers I
Pinales
Pinaceae
Pinus
Pinus subgen. Pinus

Response regulatory

HTH myb-type

Disordered

Disordered

Low complexity

Polar residues

P:phosphorelay signal transduction system


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Tineoidea Gracillariidae Conopomorpha

Disordered

Disordered

Basic residues

Polar residues

Polar residues

Low complexity

Basic and acidic residues


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides

axial binding residue

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Microhyloidea Microhylidae Dyscophinae Dyscophus

Galectin

Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.

P:negative regulation of CD4-positive, alpha-beta T cell proliferation

P:negative regulation of type II interferon production

P:positive regulation of gene expression


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

CUB


Disordered

Gly residues

P:negative regulation of cell population proliferation


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Sabellida Siboglinidae Osedax

[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)

Belongs to the chitin synthase family. Class IV subfamily

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Chitin synthase chs-1/2 N-terminal putative transporter

Disordered

Disordered

Disordered

Basic and acidic residues

Basic residues

Basic residues

Polar residues

Basic residues

Tilic E.
Miyamoto N.
Herranz M.
Worsaae K.

Hooked on zombie worms? Genetic blueprints of bristle formation in Osedax japonicus (Annelida).


Helical

Helical

Helical

axial binding residue


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Bottapotamon

Helical

Helical

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.

Rhodopsin 7-helix transmembrane proteins

G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED

G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN

Family A G protein-coupled receptor-like


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Spermatogenesis-associated protein 20-like TRX domain-containing protein


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Helical

Helical


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Echiura Xenopneusta Urechidae Urechis

Heat shock protein family A member 12 variant X7

Belongs to the heat shock protein 70 family

F:ATP-dependent protein folding chaperone


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Ionotropic glutamate receptor L-glutamate and glycine-binding

Interaction with the cone snail toxin Con-ikot-ikot

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

F:ligand-gated monoatomic ion channel activity

Eye-enriched kainate receptor, isoform A

Superoxide dismutase, copper/zinc binding domain


Helical

Helical

Helical

Helical


axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

EF-hand


Bacteria
Bacillati
Bacillota
Bacilli
Bacillales
Bacillaceae
Bacillus
Bacillus amyloliquefaciens group

Has antibacterial activity against Listeria monocytogenes

Haotian M.
Yuexia D.
Jinju P.
Yang L.
Ruixue P.
Yuner L.
Yining Z.
Xiaohui Z.
Yi M.

F:translation elongation factor activity

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


Odorant binding protein/PBP-general odorant binding protein

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pentatomoidea Pentatomidae Asopinae Eocanthecona


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Helical

Mungall A.J.
Palmer S.A.
Sims S.K.
Edwards C.A.
Ashurst J.L.
Wilming L.
Jones M.C.
Horton R.
Hunt S.E.
Scott C.E.
Gilbert J.G.
Clamp M.E.
Bethel G.
Milne S.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Andrews T.D.
Ashwell R.I.
Babbage A.K.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beare D.M.
Beasley H.
Beasley O.
Bird C.P.
Blakey S.
Bray-Allen S.
Brook J.
Brown A.J.
Brown J.Y.
Burford D.C.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Clark S.Y.
Clark G.
Clee C.M.
Clegg S.
Cobley V.
Collier R.E.
Collins J.E.
Colman L.K.
Corby N.R.
Coville G.J.
Culley K.M.
Dhami P.
Davies J.
Dunn M.
Earthrowl M.E.
Ellington A.E.
Evans K.A.
Faulkner L.
Francis M.D.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Ghori M.J.
Gilby L.M.
Gillson C.J.
Glithero R.J.
Grafham D.V.
Grant M.
Gribble S.
Griffiths C.
Griffiths M.
Hall R.
Halls K.S.
Hammond S.
Harley J.L.
Hart E.A.
Heath P.D.
Heathcott R.
Holmes S.J.
Howden P.J.
Howe K.L.
Howell G.R.
Huckle E.
Humphray S.J.
Humphries M.D.
Hunt A.R.
Johnson C.M.
Joy A.A.
Kay M.
Keenan S.J.
Kimberley A.M.
King A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.R.
Lloyd D.M.
Loveland J.E.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Maslen G.L.
Matthews L.
McCann O.T.
McLaren S.J.
McLay K.
McMurray A.
Moore M.J.
Mullikin J.C.
Niblett D.
Nickerson T.
Novik K.L.
Oliver K.
Overton-Larty E.K.
Parker A.
Patel R.
Pearce A.V.
Peck A.I.
Phillimore B.
Phillips S.
Plumb R.W.
Porter K.M.
Ramsey Y.
Ranby S.A.
Rice C.M.
Ross M.T.
Searle S.M.
Sehra H.K.
Sheridan E.
Skuce C.D.
Smith S.
Smith M.
Spraggon L.
Squares S.L.
Steward C.A.
Sycamore N.
Tamlyn-Hall G.
Tester J.
Theaker A.J.
Thomas D.W.
Thorpe A.
Tracey A.
Tromans A.
Tubby B.
Wall M.
Wallis J.M.
West A.P.
White S.S.
Whitehead S.L.
Whittaker H.
Wild A.
Willey D.J.
Wilmer T.E.
Wood J.M.
Wray P.W.
Wyatt J.C.
Young L.
Younger R.M.
Bentley D.R.
Coulson A.
Durbin R.
Hubbard T.
Sulston J.E.
Dunham I.
Rogers J.
Beck S.

The DNA sequence and analysis of human chromosome 6.


Eukaryota Amoebozoa Evosea Eumycetozoa Myxogastria Myxogastromycetidae Physariida Physaraceae Physarum

In the N-terminal section; belongs to the glycosyltransferase 20 family

Disordered

Low complexity

Minami Y.
Morita R.
Okano S.
Ishii K.
Furukawa A.
Teramoto C.

Analysis of trehalose synthesis pathway from Physarum polycephalum.

F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity

Trehalose-6-phosphate phosphatase related protein, domain 2


MADS-box

Disordered

Disordered

Polar residues

Polar residues

Polar residues

F:cis-regulatory region sequence-specific DNA binding

F:DNA-binding transcription factor activity, RNA polymerase II-specific

P:positive regulation of transcription by RNA polymerase II


Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna


Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Muzny D.M.
Scherer S.E.
Kaul R.
Wang J.
Yu J.
Sudbrak R.
Buhay C.J.
Chen R.
Cree A.
Ding Y.
Dugan-Rocha S.
Gill R.
Gunaratne P.
Harris R.A.
Hawes A.C.
Hernandez J.
Hodgson A.V.
Hume J.
Jackson A.
Khan Z.M.
Kovar-Smith C.
Lewis L.R.
Lozado R.J.
Metzker M.L.
Milosavljevic A.
Miner G.R.
Morgan M.B.
Nazareth L.V.
Scott G.
Sodergren E.
Song X.Z.
Steffen D.
Wei S.
Wheeler D.A.
Wright M.W.
Worley K.C.
Yuan Y.
Zhang Z.
Adams C.Q.
Ansari-Lari M.A.
Ayele M.
Brown M.J.
Chen G.
Chen Z.
Clendenning J.
Clerc-Blankenburg K.P.
Chen R.
Chen Z.
Davis C.
Delgado O.
Dinh H.H.
Dong W.
Draper H.
Ernst S.
Fu G.
Gonzalez-Garay M.L.
Garcia D.K.
Gillett W.
Gu J.
Hao B.
Haugen E.
Havlak P.
He X.
Hennig S.
Hu S.
Huang W.
Jackson L.R.
Jacob L.S.
Kelly S.H.
Kube M.
Levy R.
Li Z.
Liu B.
Liu J.
Liu W.
Lu J.
Maheshwari M.
Nguyen B.V.
Okwuonu G.O.
Palmeiri A.
Pasternak S.
Perez L.M.
Phelps K.A.
Plopper F.J.
Qiang B.
Raymond C.
Rodriguez R.
Saenphimmachak C.
Santibanez J.
Shen H.
Shen Y.
Subramanian S.
Tabor P.E.
Verduzco D.
Waldron L.
Wang J.
Wang J.
Wang Q.
Williams G.A.
Wong G.K.
Yao Z.
Zhang J.
Zhang X.
Zhao G.
Zhou J.
Zhou Y.
Nelson D.
Lehrach H.
Reinhardt R.
Naylor S.L.
Yang H.
Olson M.
Weinstock G.
Gibbs R.A.

The DNA sequence, annotation and analysis of human chromosome 3.


Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Rhodopsin 7-helix transmembrane proteins

Family A G protein-coupled receptor-like


Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Crucial to convey clamshell closure to channel opening

F:ligand-gated monoatomic ion channel activity


Helical

Helical


Belongs to the glycosyl hydrolase 31 family

Glycoside hydrolase family 31 TIM barrel

Glycosyl hydrolase family 31 C-terminal

F:hydrolase activity, hydrolyzing O-glycosyl compounds


Helical


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Rhynchonelliformea Rhynchonellata Terebratellidina Laqueoidea Laqueidae Terebratalia

Lacks conserved residue(s) required for the propagation of feature annotation

WIF

EGF-like

EGF-like

Disordered

Vellutini B.C.
Martin-Duran J.M.
Borve A.
Hejnol A.

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.

Latent-transforming growth factor beta-binding protein 1


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Liliopsida Arecaceae Calamoideae Calameae Salaccinae Salacca

Disordered

PROTEIN EARLY RESPONSIVE TO DEHYDRATION 15


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Pinopsida
Pinidae
Conifers I
Pinales
Pinaceae
Pinus
Pinus subgen. Pinus

DNA2/NAM7 helicase helicase

Disordered

Disordered

Polar residues

Basic and acidic residues

Basic residues

Identification of RNAi-Related Genes and Transcriptome Assembly of Loblolly Pine (Pinus taeda, L.) Seedlings Exposed to Insect-Specific dsRNA.

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Proctotrupomorpha Chalcidoidea Trichogrammatidae Trichogramma

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:37379839). Directly binds some unknown ligand, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor (PubMed:37379839)

pppGp(2'-5')A = 2',3'-cGAMP + diphosphate

Cyclic GMP-AMP synthase-like receptor

Murali S.
Richards S.
Bandaranaike D.
Bellair M.
Blankenburg K.
Chao H.
Dinh H.
Doddapaneni H.
Dugan-Rocha S.
Elkadiri S.
Gnanaolivu R.
Hernandez B.
Skinner E.
Javaid M.
Lee S.
Li M.
Ming W.
Munidasa M.
Muniz J.
Nguyen L.
Hughes D.
Osuji N.
Pu L.-L.
Puazo M.
Qu C.
Quiroz J.
Raj R.
Weissenberger G.
Xin Y.
Zou X.
Han Y.
Worley K.
Muzny D.
Gibbs R.

Li Y.
Slavik K.M.
Toyoda H.C.
Morehouse B.R.
de Oliveira Mann C.C.
Elek A.
Levy S.
Wang Z.
Mears K.S.
Liu J.
Kashin D.
Guo X.
Mass T.
Sebe-Pedros A.
Schwede F.
Kranzusch P.J.

cGLRs are a diverse family of pattern recognition receptors in innate immunity.

F:2',3'-cyclic GMP-AMP synthase activity

CELL FATE DETERMINING PROTEIN MAB21-RELATED

CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Dendrobranchiata Penaeoidea Penaeidae Penaeus

Hemocyanin subunit-like antimicrobial peptide

Hemocyanin middle

Naveenkumar R.
Panigrahi A.
Bedekar M.
Saranya C.

Di-copper center containing domain from catechol oxidase


Heat shock protein family A member 12 variant X5

Belongs to the heat shock protein 70 family

Disordered

Basic and acidic residues

F:ATP-dependent protein folding chaperone


Helical

Helical

Helical

Helical

Helical


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


PIN2 (TERF1) interacting telomerase inhibitor 1


Tudor domain-containing protein-like protein

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Acidic residues

Basic and acidic residues

Acidic residues

Acidic residues

Acidic residues

Acidic residues

Acidic residues

Basic and acidic residues

Acidic residues

Acidic residues

Polar residues

Low complexity


Muscrinic acethylcholine receptor-like GPCR protein

Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

F:G protein-coupled acetylcholine receptor activity

F:G protein-coupled serotonin receptor activity

P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Rhodopsin 7-helix transmembrane proteins

Family A G protein-coupled receptor-like


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Chondrostei Acipenseriformes Acipenseridae Acipenser

Ig-like

F:transmembrane receptor protein tyrosine kinase activity

P:cell surface receptor protein tyrosine kinase signaling pathway

IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS


VWFA


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

RRM

Kostyuchenko R.P.
Nikanorova D.D.
Amosov A.V.

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.

P:positive regulation of translational initiation


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
malvids
Myrtales
Myrtaceae
Myrtoideae
Myrteae
Pimenta group
Psidium

Terpene synthase N-terminal

Terpene synthase metal-binding

Disordered

Polar residues

Canal D.
dos Santos P.H.D.
Carpinetti-Oliveira P.A.
Silva M.A.
Fernandes M.
Brustolini O.J.B.
Ferreira A.
Ferreira M.F.S.

Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.

TERPENE SYNTHASE FAMILY, METAL-BINDING DOMAIN PROTEIN


Serine/threonine-protein kinase STE20-like protein

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)

Helical

Protein kinase

Disordered

Disordered


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Caelifera Acrididea Acridomorpha Acridoidea Acrididae Oedipodinae Locusta

Tudor

Disordered

Disordered

Disordered

Polar residues

Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Lacks conserved residue(s) required for the propagation of feature annotation

Helical

Helical

Helical

Helical

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Inosine/uridine-preferring nucleoside hydrolase

F:hydrolase activity, hydrolyzing N-glycosyl compounds


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Eupercaria Sciaenidae Argyrosomus

T-cell surface glycoprotein CD3 zeta chain

Helical

Disordered

HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR GAMMA-SUBUNIT

HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT GAMMA


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

P:positive regulation of transcription by RNA polymerase II


Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Errantia Eunicida Eunicidae Palola

BHLH

PAS

PAS

Disordered

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Low complexity

Low complexity

Low complexity

Polar residues

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

Hypoxia-inducible factor 1 subunit alpha

Hypoxia-inducible factor 1-alpha isoform 1

HLH, helix-loop-helix DNA-binding domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Gelechioidea Gelechiidae Gelechiinae Tuta

Helical

Helical

Ryanodine Receptor TM 4-6

Disordered

Gly residues

Muthu Lakshmi Bavithra C.
Murugan M.
Balasubramani V.
Kumar K.
Harish S.
Jayakanthan M.

Identification of ryanodine receptor mutation in insecticide resistant Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) population of South India.

F:ryanodine-sensitive calcium-release channel activity

P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Helical

EGF-like

DOMON

DOMON

Disordered

Acidic residues

Acidic residues


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Microhyloidea Brevicipitidae Breviceps

IgGFc-binding protein N-terminal

Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.


Disordered

Pro residues


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Helical

Helical

Helical

Helical

Helical

Helical

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Loganiaceae Strychnos

Malonylransferase involved in the biosynthesis of curare monoterpene indole alkaloids (MIAs), natural products such as strychnine, a neurotoxic compound used as a pesticide to control rodents, and its pharmacologically active derivatives, including brucine, used to regulate blood pressure (PubMed:35794473). Curare alkaloids act as animal glycine receptor antagonists (PubMed:35794473). Catalyzes the conversion of 17,18-epoxy-17-hydroxycur-19-ene (Wieland-Gumlich aldehyde) to prestrychnine, which is spontaneously converted into strychnine and isostrychnine (PubMed:35794473)

17,18-epoxy-17-hydroxycur-19-ene + malonyl-CoA = prestrychnine + CoA

Belongs to the plant acyltransferase family

17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase

Proton acceptor

Proton acceptor

Hong B.
Grzech D.
Caputi L.
Sonawane P.
Lopez C.E.R.
Kamileen M.O.
Hernandez Lozada N.J.
Grabe V.
O'Connor S.E.

Biosynthesis of strychnine.

NUCLEOTIDE SEQUENCE [MRNA]
FUNCTION
CATALYTIC ACTIVITY
PATHWAY
TISSUE SPECIFICITY
SUBCELLULAR LOCATION


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Disordered

Disordered

Basic and acidic residues

Acidic residues

Low complexity

Acidic residues

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

F:ligand-gated monoatomic ion channel activity


Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Lacks conserved residue(s) required for the propagation of feature annotation

Helical

Helical

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.

F:translation elongation factor activity


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

PUM-HD

Pumilio

Disordered

Disordered

Basic residues

Acidic residues

Polar residues

Basic and acidic residues


Cystatin

F:cysteine-type endopeptidase inhibitor activity


RRM

MYND-type

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Disordered

Disordered

Disordered

Disordered

Polar residues

Polar residues

Polar residues

Polar residues


Helical

Helical

Helical

Disordered

Low complexity

Basic and acidic residues

Polar residues

Glutamate receptor ionotropic, kainate 1

Putative glutamate receptor ionotropic kainate 1


Succinate dehydrogenase complex iron sulfur subunit B


Helical


After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily

Helical

Helical

Helical

Helical

F:acetylcholine-gated monoatomic cation-selective channel activity

F:transmembrane signaling receptor activity

Nicotinic acetylcholine receptor subunit alpha4

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like


Disordered

Disordered

Low complexity

Low complexity


Belongs to the secreted frizzled-related protein (sFRP) family

FZ

NTR

Mikhailov K.
Kravchuk O.
Lyupina Y.
Adameyko K.


Belongs to the UDP-glycosyltransferase family


Helical

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Basic and acidic residues

Rhodopsin 7-helix transmembrane proteins

Family A G protein-coupled receptor-like


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Belongs to the glycosyl hydrolase 56 family

Hyaluronidase

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.


Belongs to the krueppel C2H2-type zinc-finger protein family


Helical

Ig-like


Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Curculionidae Scolytinae Ips

Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Lacks conserved residue(s) required for the propagation of feature annotation

Helical

Helical

Helical

Helical

Helical

Biswas T.
Sims C.
Yuvaraj J.K.
Roberts R.E.
Lofstedt C.
Andersson M.N.

Functional characterization supports multiple evolutionary origins of pheromone receptors bark beetles.


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Aplacophora Caudofoveata Chaetodermatida Prochaetodermatidae Spathoderma

BHLH

PAS

PAS

Disordered

Disordered

Low complexity

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1

HLH, helix-loop-helix DNA-binding domain


Disordered

Basic and acidic residues


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Aculeata Formicoidea Formicidae Myrmicinae Pogonomyrmex

Vertebrate-selective toxin that causes pain by targeting voltage-gated sodium channels

Belongs to the formicidae venom clade 1 family

Disordered

Acidic residues

Low complexity

Asparagine amide

Voltage-gated sodium channel impairing toxin

Robinson S.D.
Deuis J.R.
Niu P.
Touchard A.
Mueller A.
Schendel V.
Brinkwirth N.
King G.F.
Vetter I.
Schmidt J.O.

Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants.

NUCLEOTIDE SEQUENCE [MRNA]
PROBABLE AMIDATION AT ASN-61


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Tityus

Cryptide Pep-15

Dias N.B.
de Souza B.M.
Cocchi F.K.
Chalkidis H.M.
Dorce V.A.C.
Palma M.S.

Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.

PROTEIN SEQUENCE
IDENTIFICATION BY MASS SPECTROMETRY
MASS SPECTROMETRY
SUBCELLULAR LOCATION


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia


Eukaryota Metazoa Chordata Craniata Vertebrata Chondrichthyes Elasmobranchii Galeomorphii Galeoidea Orectolobiformes Ginglymostomatidae Ginglymostoma

Ig-like

Janes M.E.
Kinlein A.
Flajnik M.F.
Du Pasquier L.
Ohta Y.

Genomic view of the origins of cell-mediated immunity.

P:cell surface receptor signaling pathway

P:cellular response to lipopolysaccharide

P:negative regulation of T cell proliferation

P:positive regulation of T cell proliferation

FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

axial binding residue

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Cryptide Pep-14

PROTEIN SEQUENCE
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Erebidae Lymantriinae Lymantria

ETS

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Basic and acidic residues

Low complexity

Basic residues

F:DNA-binding transcription activator activity, RNA polymerase II-specific

P:regulation of development, heterochronic

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain


Eukaryota Metazoa Porifera Calcarea Calcinea Clathrinida Leucettidae Leucetta

BZIP

Disordered

Disordered

Low complexity

Basic and acidic residues

Basic and acidic residues

Gene networks governing the response of a calcareous sponge to future ocean conditions reveal lineage-specific XBP1 regulation of the unfolded protein response.


axial binding residue


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space

Heterodimer of 2 subunits, IMP1A/B and IMP12

Belongs to the peptidase S26 family. IMP1 subfamily

Peptidase S26

Peptidase S26

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

C:mitochondrial inner membrane peptidase complex

P:protein processing involved in protein targeting to mitochondrion

MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1-LIKE

PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Helical

Helical

Helical

Helical


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Chemokine interleukin-8-like

Disordered

Low complexity

Polar residues

Basic and acidic residues

Humphray S.J.
Oliver K.
Hunt A.R.
Plumb R.W.
Loveland J.E.
Howe K.L.
Andrews T.D.
Searle S.
Hunt S.E.
Scott C.E.
Jones M.C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Ashwell R.I.
Babbage A.K.
Babbage S.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beasley H.
Beasley O.
Bird C.P.
Bray-Allen S.
Brown A.J.
Brown J.Y.
Burford D.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Chen Y.
Clarke G.
Clark S.Y.
Clee C.M.
Clegg S.
Collier R.E.
Corby N.
Crosier M.
Cummings A.T.
Davies J.
Dhami P.
Dunn M.
Dutta I.
Dyer L.W.
Earthrowl M.E.
Faulkner L.
Fleming C.J.
Frankish A.
Frankland J.A.
French L.
Fricker D.G.
Garner P.
Garnett J.
Ghori J.
Gilbert J.G.
Glison C.
Grafham D.V.
Gribble S.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Guy J.
Hall R.E.
Hammond S.
Harley J.L.
Harrison E.S.
Hart E.A.
Heath P.D.
Henderson C.D.
Hopkins B.L.
Howard P.J.
Howden P.J.
Huckle E.
Johnson C.
Johnson D.
Joy A.A.
Kay M.
Keenan S.
Kershaw J.K.
Kimberley A.M.
King A.
Knights A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.
Lloyd D.M.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
McLaren S.
McLay K.E.
McMurray A.
Milne S.
Nickerson T.
Nisbett J.
Nordsiek G.
Pearce A.V.
Peck A.I.
Porter K.M.
Pandian R.
Pelan S.
Phillimore B.
Povey S.
Ramsey Y.
Rand V.
Scharfe M.
Sehra H.K.
Shownkeen R.
Sims S.K.
Skuce C.D.
Smith M.
Steward C.A.
Swarbreck D.
Sycamore N.
Tester J.
Thorpe A.
Tracey A.
Tromans A.
Thomas D.W.
Wall M.
Wallis J.M.
West A.P.
Whitehead S.L.
Willey D.L.
Williams S.A.
Wilming L.
Wray P.W.
Young L.
Ashurst J.L.
Coulson A.
Blocker H.
Durbin R.
Sulston J.E.
Hubbard T.
Jackson M.J.
Bentley D.R.
Beck S.
Rogers J.
Dunham I.

DNA sequence and analysis of human chromosome 9.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Whippomorpha Cetacea Mysticeti Eschrichtiidae Eschrichtius

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data

Bruniche-Olsen A.
Black A.N.
Fields C.J.
Walden K.
Dewoody J.A.

Whole genome sequence of Eschrichtius robustus ER-17-0199.

F:DNA-binding transcription factor activity

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

P:regulation of transcription by RNA polymerase II


Belongs to the glycosyltransferase 6 family

Nucleophile

Zhong J.
Gao Y.M.
Mo C.P.
Zhang Y.
Li L.B.
Wei S.T.
Li T.Y.

Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A

HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE


Helical

Helical

Helical

Helical


Toxin that causes a rapid and irreversible paralysis when intrathoracically injected into insects (blowflies). Does not cause spontaneous nocifensive behaviors by intraplantar injection in mice

PD(50) [1 hour] is 43.7 nmol/g when intrathoracically injected into insects (blowfly L.caesar)

Negative results: does not exhibit hemolytic and cytotoxic activities on HEK293 cells

Belongs to the formicidae venom clade 2 family

Glutamine amide

NUCLEOTIDE SEQUENCE [MRNA]
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION
SYNTHESIS OF 34-60
BIOASSAY
TOXIC DOSE
AMIDATION AT GLN-60


von Willebrand factor A domain-containing protein-like protein

Lacks conserved residue(s) required for the propagation of feature annotation

VWFA

EGF-like

EGF-like

EGF-like

EGF-like

VWFA

VWFA

Disordered

Disordered

Disordered

Pro residues

Basic and acidic residues

Basic and acidic residues

Low complexity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

CUB

Disordered


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Megalopygidae Megalopyge

Pyrrolidone carboxylic acid

Threonine amide

Walker A.A.
Robinson S.D.
Merritt D.J.
Cardoso F.C.
Goudarzi M.H.
Mercedes R.S.
Eagles D.A.
Cooper P.
Zdenek C.N.
Fry B.G.
Hall D.W.
Vetter I.
King G.F.

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).

NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
SYNTHESIS OF 26-55
PYROGLUTAMATE FORMATION AT GLN-26
AMIDATION AT THR-55
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


IF rod

LTD

Disordered

Disordered

Polar residues

Acidic residues

Intermediate filament protein, coiled coil region


Bacteria
Pseudomonadati
Chlamydiota
Chlamydiia
Chlamydiales
Chlamydiaceae
Chlamydia/Chlamydophila group
Chlamydia

T-Q ester bond containing

Disordered

Polar residues

Intramolecular ester bond-containing repeat domain from Chlamydia trachomatis adhesin.

X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH CA(2+)


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Paratelphusula

Helical

Rhodopsin 7-helix transmembrane proteins


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Cilia- and flagella-associated protein 184 isoform X1

CCDC113/CCDC96 coiled-coil

Disordered

Acidic residues

Polar residues

Acidic residues

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.

COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED

COILED-COIL DOMAIN-CONTAINING PROTEIN 96


Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Helical

Helical

Helical

Helical

Helical

Helical


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Eupercaria Sciaenidae Argyrosomus

Genetic markers of meagre immune system activation.


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Aplacophora Solenogastres Pholidoskepia Meiomeniidae Meiomenia

PAS

PAS

Disordered

Disordered

Disordered

Polar residues

Low complexity

Polar residues

Basic and acidic residues

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Disordered

B3 DOMAIN-CONTAINING PROTEIN REM-LIKE 3-RELATED

B3 DOMAIN-CONTAINING PROTEIN REM14-RELATED


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Disordered

Low complexity

F:dopamine neurotransmitter receptor activity, coupled via Gi/Go

ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR

Family A G protein-coupled receptor-like


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes


CUB

Disordered

Basic and acidic residues


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Elongation factor 1 beta central acidic region eukaryote

Disordered

Acidic residues

Augustine N.
Selvapandian U.
Muthugoundar M.

Evaluation of reference genes for expression studies in the broad mite, Polyphagotarsonemus latus (Acari: Tarsonemidae).

C:eukaryotic translation elongation factor 1 complex

F:guanyl-nucleotide exchange factor activity

F:translation elongation factor activity

EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER


Lacks conserved residue(s) required for the propagation of feature annotation

FZ


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Portunoidea Portunidae Portuninae Scylla

Disordered

Disordered

Polar residues

Basic and acidic residues

Polar residues


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Zygentoma Lepismatidae Thermobia

HTH psq-type

HTH psq-type

H-T-H motif

H-T-H motif

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Low complexity

Polar residues

Polar residues

Polar residues

Basic residues

Basic and acidic residues

Basic and acidic residues

Low complexity

Polar residues

Basic and acidic residues

Acidic residues

Polar residues

P:regulation of transcription by RNA polymerase II


Belongs to the integrin beta chain family

Integrin beta subunit VWA

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Thysanoptera Terebrantia Thripoidea Thripidae Thrips

Belongs to the major royal jelly protein family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


axial binding residue


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Deleted in malignant brain tumors 1 protein-like protein 1

Helical

SRCR

SRCR

SRCR

SRCR

SRCR

SRCR

Scavenger receptor cysteine-rich protein type 12


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Liliopsida Liliales Liliaceae Lilium

The jas domain is required for interaction with COI1

Protein TIFY

Tify

Disordered

P:regulation of jasmonic acid mediated signaling pathway


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Rhynchonelliformea Rhynchonellata Rhynchonellida Hemithiridoidea Hemithyrididae Hemithiris

BHLH

PAS

PAS

Disordered

Disordered

Basic and acidic residues

Polar residues

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1

HLH, helix-loop-helix DNA-binding domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Auchenorrhyncha Fulgoroidea Delphacidae Delphacinae Sogatella

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Belongs to the glycosyl hydrolase 20 family

Glycoside hydrolase family 20 catalytic


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate

Calcineurin-like phosphoesterase

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Neonatal crystallizable Fc receptor FcRn splice variant 6

Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.


axial binding residue

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen


Cytochrome P450 - CYP3636A1 short isoform

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides

Helical

Helical

Disordered

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Curculionidae Curculioninae Anthonomini Anthonomus

Helical

Segura Leon O.L.
Lechuga-Paredes P.
Cibrian Tovar J.
Torres Huerta B.

Lechuga-Paredes P.
Segura-Leon O.L.
Cibrian-Tovar J.
Torres-Huerta B.
Velazquez-Gonzalez J.C.
Cruz-Jaramillo J.L.

Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.

Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3

EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Ensifera Tettigoniidea Tettigonioidea Tettigoniidae Tettigoniinae Anabrus

Belongs to the DNA/RNA non-specific endonuclease family

DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase

ENPP1-3/EXOG-like endonuclease/phosphodiesterase

Proton acceptor

F:single-stranded DNA endodeoxyribonuclease activity


Importin N-terminal

Disordered

Acidic residues

Mikhailov K.
Kravchuk O.
Lyupina Y.
Adameyko K.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Peptidase S1


Epithelial sodium channel/degenerin-like protein

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family

Helical

Disordered

Disordered

Low complexity

Low complexity

Basic and acidic residues

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Peracarida Isopoda Oniscidea Crinocheta Paraplatyarthridae Paraplatyarthrus

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Belongs to the glycosyl hydrolase 9 (cellulase E) family

cellulase

Glycoside hydrolase family 9

Javidkar M.
Cooper S.J.B.
Shokri Bousjein N.
Humphreys W.F.
King R.A.
Austin A.D.

Evolution of endoglucanase genes in subterranean and surface isopod crustaceans from Central Western Australia.

F:hydrolase activity, hydrolyzing O-glycosyl compounds


Bone morphogenetic protein receptor type 1A

Helical

Activin types I and II receptor

Deloukas P.
Earthrowl M.E.
Grafham D.V.
Rubenfield M.
French L.
Steward C.A.
Sims S.K.
Jones M.C.
Searle S.
Scott C.
Howe K.
Hunt S.E.
Andrews T.D.
Gilbert J.G.
Swarbreck D.
Ashurst J.L.
Taylor A.
Battles J.
Bird C.P.
Ainscough R.
Almeida J.P.
Ashwell R.I.
Ambrose K.D.
Babbage A.K.
Bagguley C.L.
Bailey J.
Banerjee R.
Bates K.
Beasley H.
Bray-Allen S.
Brown A.J.
Brown J.Y.
Burford D.C.
Burrill W.
Burton J.
Cahill P.
Camire D.
Carter N.P.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.M.
Clegg S.
Corby N.
Coulson A.
Dhami P.
Dutta I.
Dunn M.
Faulkner L.
Frankish A.
Frankland J.A.
Garner P.
Garnett J.
Gribble S.
Griffiths C.
Grocock R.
Gustafson E.
Hammond S.
Harley J.L.
Hart E.
Heath P.D.
Ho T.P.
Hopkins B.
Horne J.
Howden P.J.
Huckle E.
Hynds C.
Johnson C.
Johnson D.
Kana A.
Kay M.
Kimberley A.M.
Kershaw J.K.
Kokkinaki M.
Laird G.K.
Lawlor S.
Lee H.M.
Leongamornlert D.A.
Laird G.
Lloyd C.
Lloyd D.M.
Loveland J.
Lovell J.
McLaren S.
McLay K.E.
McMurray A.
Mashreghi-Mohammadi M.
Matthews L.
Milne S.
Nickerson T.
Nguyen M.
Overton-Larty E.
Palmer S.A.
Pearce A.V.
Peck A.I.
Pelan S.
Phillimore B.
Porter K.
Rice C.M.
Rogosin A.
Ross M.T.
Sarafidou T.
Sehra H.K.
Shownkeen R.
Skuce C.D.
Smith M.
Standring L.
Sycamore N.
Tester J.
Thorpe A.
Torcasso W.
Tracey A.
Tromans A.
Tsolas J.
Wall M.
Walsh J.
Wang H.
Weinstock K.
West A.P.
Willey D.L.
Whitehead S.L.
Wilming L.
Wray P.W.
Young L.
Chen Y.
Lovering R.C.
Moschonas N.K.
Siebert R.
Fechtel K.
Bentley D.
Durbin R.
Hubbard T.
Doucette-Stamm L.
Beck S.
Smith D.R.
Rogers J.

The DNA sequence and comparative analysis of human chromosome 10.

F:transmembrane receptor protein serine/threonine kinase activity

Receptor protein serine/threonine kinase


Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Helical

Helical


Viruses
Varidnaviria
Bamfordvirae
Preplasmiviricota
Tectiliviricetes
Rowavirales
Adenoviridae
Mastadenovirus
Mastadenovirus tarandri

Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus

Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response

Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion

Expressed in the late phase of the viral replicative cycle

Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell

Belongs to the adenoviridae histone-like nucleoprotein family

Lacks conserved residue(s) required for the propagation of feature annotation

Removed

Pre-histone-like nucleoprotein

Histone-like nucleoprotein

Disordered

Cleavage; by viral protease

Dastjerdi A.
Jeckel S.
Davies H.
Irving J.
Lounge C.
Plummer C.
Vidovszky M.Z.
Harrach B.
Chantrey J.
Williams J.

Novel adenovirus associated with necrotizing bronchiolitis in a captive reindeer (Rangifer tarandus).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Megalopygidae Megalopyge

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).

NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
SYNTHESIS OF 24-48
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Fabales Fabaceae Detarioideae Saraceae Saraca

Transcriptome analysis of Saraca asoca.


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

P:adenylate cyclase-activating adrenergic receptor signaling pathway

Rhodopsin 7-helix transmembrane proteins

ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR

Family A G protein-coupled receptor-like


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Ligated ion channel binding I - glutamate


NTR

Disordered

Pro residues


Eukaryota Metazoa Porifera Calcarea Calcinea Clathrinida Leucettidae Leucetta

BZIP

Disordered

Gene networks governing the response of a calcareous sponge to future ocean conditions reveal lineage-specific XBP1 regulation of the unfolded protein response.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Polypodiopsida
Polypodiidae
Polypodiales
Pteridineae
Pteridaceae
Pteridoideae
Pteris
Pteris subgen. Campteria
Pteris sect. Excelsae

Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family

Helical

Helical

Helical

Helical

Helical

Helical

F:phosphate transmembrane transporter activity


Disordered

Low complexity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Odorant binding protein/PBP-general odorant binding protein

Helical

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Belongs to the small GTPase superfamily. Ras family

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Microhyloidea Brevicipitidae Breviceps

Galectin

Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.


FZ


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Nitidulidae Nitidulinae Aethina

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:37379839). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:37379839). Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor (PubMed:37379839)

Cyclic GMP-AMP synthase-like receptor

Disordered

Polar residues

Evans J.
Huang Q.
Sim S.B.
Corpuz R.L.
Simmonds T.J.
Childers A.
Kuhn K.
Smith T.
Geib S.M.

Chromosome-scale assembly of Aethina tumida.

Li Y.
Slavik K.M.
Toyoda H.C.
Morehouse B.R.
de Oliveira Mann C.C.
Elek A.
Levy S.
Wang Z.
Mears K.S.
Liu J.
Kashin D.
Guo X.
Mass T.
Sebe-Pedros A.
Schwede F.
Kranzusch P.J.

cGLRs are a diverse family of pattern recognition receptors in innate immunity.

F:2',3'-cyclic GMP-AMP synthase activity

CELL FATE DETERMINING PROTEIN MAB21-RELATED

CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED


Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Helical

Helical

Helical

Helical

Helical

Helical

Helical


Bacteria Bacillati Actinomycetota Actinomycetes Micrococcales Microbacteriaceae Microbacterium

3'-dehydrocarminate deglycosidase beta subunit

Carbon-carbon bond-cleaving enzyme which participates in a carminate degradation pathway (PubMed:34728636). Cleaves the C-C bond in 3'-dehydrocarminate to form kermesate (PubMed:34728636). Also shows weak activity with other C-glycosides, such as 3''-dehydropuerarin (3''-oxo-puerarin), 3''-dehydroisoorientin (3''-oxo-homoorientin) and 3'-dehydromangiferin (3'-oxo-mangiferin) (PubMed:34728636)

3'-dehydrocarminate + H(+) = kermesate + 1,5-anhydro-D-erythro-hex-1-en-3-ulose

Activity is strongly reduced in the presence of chelating agents

kcat is 23 min(-1) with 3'-dehydrocarminate as substrate. kcat is 0.12 min(-1) with 3''-dehydropuerarin as substrate. kcat is 0.024 min(-1) with 3''-dehydroisoorientin as substrate. kcat is 0.16 min(-1) with 3'-dehydromangiferin as substrate.

Optimum temperature is around 40 degrees Celsius.

Heterodimer composed of an alpha subunit (CarB) and a beta subunit (CarC)

Belongs to the C-glycoside deglycosidase beta subunit family

Mori T.
Kumano T.
He H.
Watanabe S.
Senda M.
Moriya T.
Adachi N.
Hori S.
Terashita Y.
Kawasaki M.
Hashimoto Y.
Awakawa T.
Senda T.
Abe I.
Kobayashi M.

C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes.

NUCLEOTIDE SEQUENCE [GENOMIC DNA]
FUNCTION
CATALYTIC ACTIVITY
COFACTOR
ACTIVITY REGULATION
BIOPHYSICOCHEMICAL PROPERTIES
SUBUNIT