Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Disordered


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

Disordered

Basic residues

Basic residues

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.

Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Helical


Helical

axial binding residue


Eukaryota Sar Stramenopiles Oomycota Peronosporales Peronosporaceae Phytophthora

Structure of RxLR121 effector from phytophthora capsici.


SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)

Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family

Helical

Helical

Helical

Helical

Major facilitator superfamily (MFS) profile

Disordered

International Human Genome Sequencing Consortium

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Finishing the euchromatic sequence of the human genome.

Zody M.C.
Garber M.
Adams D.J.
Sharpe T.
Harrow J.
Lupski J.R.
Nicholson C.
Searle S.M.
Wilming L.
Young S.K.
Abouelleil A.
Allen N.R.
Bi W.
Bloom T.
Borowsky M.L.
Bugalter B.E.
Butler J.
Chang J.L.
Chen C.K.
Cook A.
Corum B.
Cuomo C.A.
de Jong P.J.
DeCaprio D.
Dewar K.
FitzGerald M.
Gilbert J.
Gibson R.
Gnerre S.
Goldstein S.
Grafham D.V.
Grocock R.
Hafez N.
Hagopian D.S.
Hart E.
Norman C.H.
Humphray S.
Jaffe D.B.
Jones M.
Kamal M.
Khodiyar V.K.
LaButti K.
Laird G.
Lehoczky J.
Liu X.
Lokyitsang T.
Loveland J.
Lui A.
Macdonald P.
Major J.E.
Matthews L.
Mauceli E.
McCarroll S.A.
Mihalev A.H.
Mudge J.
Nguyen C.
Nicol R.
O'Leary S.B.
Osoegawa K.
Schwartz D.C.
Shaw-Smith C.
Stankiewicz P.
Steward C.
Swarbreck D.
Venkataraman V.
Whittaker C.A.
Yang X.
Zimmer A.R.
Bradley A.
Hubbard T.
Birren B.W.
Rogers J.
Lander E.S.
Nusbaum C.

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

MFS general substrate transporter like domains


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Helical

Disordered

Basic and acidic residues

Low complexity


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Portunoidea Portunidae Portuninae Scylla

Disordered

Low complexity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Helical

Helical

Helical

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate

Belongs to the histidine acid phosphatase family

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.

P:chondroitin sulfate proteoglycan biosynthetic process


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Sabellida Siboglinidae Ridgeia

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data

Ig-like

Perez M.
Aroh O.
Sun Y.
Lan Y.
Juniper S.K.
Young C.R.
Angers B.
Qian P.Y.

Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.

CARTILAGE INTERMEDIATE LAYER PROTEIN 1-LIKE ISOFORM X1

CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Ranunculales Papaveraceae Fumarioideae Corydalis

Helical

Helical

axial binding residue

P:isoquinoline alkaloid biosynthetic process


Disordered

Acidic residues

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


S S.B.
Negi N.
Nagarjuna Reddy K.
R G.G.

Takout-proteins of Maconellicoccus hirsutus.

Haemolymph juvenile hormone binding protein

CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN


N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA = N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA

Helical

CoA carboxyltransferase C-terminal

F:carboxyl- or carbamoyltransferase activity

2-enoyl-CoA Hydratase, Chain A, domain 1


Archaea
Promethearchaeati
Promethearchaeota
Promethearchaeia
Promethearchaeales
Promethearchaeaceae
Candidatus Harpocratesius

PAZ

Piwi

Bastiaanssen C.
Bobadilla Ugarte P.
Kim K.
Finocchio G.
Feng Y.
Anzelon T.A.
Kostlbacher S.
Tamarit D.
Ettema T.J.G.
Jinek M.
MacRae I.J.
Joo C.
Swarts D.C.
Wu F.

RNA-guided RNA silencing by an Asgard archaeal Argonaute.

STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS)

Ribonuclease H-like superfamily/Ribonuclease H

EUKARYOTIC TRANSLATION INITIATION FACTOR 2C


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Cephalopoda Coleoidea Octopodiformes Octopoda Incirrata Octopodidae Callistoctopus

Belongs to the group II decarboxylase family

Disordered

Polar residues

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE


Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.


F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


F:cysteine-type endopeptidase inhibitor activity


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Echiura Xenopneusta Urechidae Urechis

Heat shock protein family A member 12 variant X2

Belongs to the heat shock protein 70 family

F:ATP-dependent protein folding chaperone


Deoxyribonuclease

Endonuclease/exonuclease/phosphatase

Essential for enzymatic activity


Disordered

Low complexity

Gly residues

F:extracellular matrix structural constituent conferring tensile strength


Eukaryota Metazoa Echinodermata Eleutherozoa Echinozoa Holothuroidea Aspidochirotacea Aspidochirotida Stichopodidae Apostichopus

Guanylate-binding protein N-terminal

P-loop containing nucleotide triphosphate hydrolases

Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain

P-loop containing nucleoside triphosphate hydrolases


Haemolymph juvenile hormone binding protein

CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Auchenorrhyncha Membracoidea Cicadellidae Typhlocybinae Empoascini Empoasca

Disordered

Disordered

Low complexity

Low complexity

Low complexity

Low complexity

Acidic residues

Low complexity

C:cytoplasmic side of apical plasma membrane

P:positive regulation of hippo signaling

FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY


Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Eurotiomycetes Eurotiomycetidae Eurotiales Aspergillaceae Penicillium

Arginine-containing cyclodipeptide synthase pthA

Arginine-containing cyclodipeptide synthase; part of the cluster that mediates the biosynthesis of a highly modified cyclo-arginine-aspartate dipeptide (cRD) (PubMed:36702957). Within the pathway, pthA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Asp diketopiperazine (cRW) from L-arginyl-tRNA(Arg) + L-aspartyl-tRNA(Asp) (PubMed:36702957). Additional enzymes from the cluster then further modify the cyclo-Arg-Asp diketopiperazine (cRW) scaffold (Probable)

L-aspartyl-tRNA(Asp) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-aspartyl) + tRNA(Asp) + tRNA(Arg) + 2 H(+)

The conserved DDXXE motif is essential for catalytic activity

Belongs to the arginine-containing cyclodipeptide synthase family

Conserved DDXXE motif

Yee D.A.
Niwa K.
Perlatti B.
Chen M.
Li Y.
Tang Y.

Genome mining for unknown-unknown natural products.

NUCLEOTIDE SEQUENCE [MRNA]
FUNCTION
CATALYTIC ACTIVITY
PATHWAY


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Aparapotamon

Cation-independent mannose-6-phosphate receptor-like protein

MRH

Disordered

Polar residues

Mannose-6-phosphate receptor binding domain

MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1

MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Terebellida Terebelliformia Alvinellidae Alvinella

Interchain

Longo M.A.
Roy S.
Chen Y.
Tomaszowski K.H.
Arvai A.S.
Pepper J.T.
Boisvert R.A.
Kunnimalaiyaan S.
Keshvani C.
Schild D.
Bacolla A.
Williams G.J.
Tainer J.A.
Schlacher K.

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.

X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH ZN(2+)


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Aculeata Apoidea Anthophila Apidae Scaptotrigona

Leon-Estrada N.
Garcia-Fajardo L.V.
Rojas-Leon J.C.
Guillen-Navarro K.

Pheromone/general odorant binding protein domain


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:cis-regulatory region sequence-specific DNA binding

F:DNA-binding transcription factor activity, RNA polymerase II-specific

P:positive regulation of transcription by RNA polymerase II


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

axial binding residue

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Eukaryota Fungi Dikarya Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces

Uncharacterized protein YMR106W-A

Bowman S.
Churcher C.M.
Badcock K.
Brown D.
Chillingworth T.
Connor R.
Dedman K.
Devlin K.
Gentles S.
Hamlin N.
Hunt S.
Jagels K.
Lye G.
Moule S.
Odell C.
Pearson D.
Rajandream M.A.
Rice P.
Skelton J.
Walsh S.V.
Whitehead S.
Barrell B.G.

The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.

Engel S.R.
Dietrich F.S.
Fisk D.G.
Binkley G.
Balakrishnan R.
Costanzo M.C.
Dwight S.S.
Hitz B.C.
Karra K.
Nash R.S.
Weng S.
Wong E.D.
Lloyd P.
Skrzypek M.S.
Miyasato S.R.
Simison M.
Cherry J.M.

The reference genome sequence of Saccharomyces cerevisiae: Then and now.

Engel S.R.
Wong E.D.
Nash R.S.
Aleksander S.
Alexander M.
Douglass E.
Karra K.
Miyasato S.R.
Simison M.
Skrzypek M.S.
Weng S.
Cherry J.M.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources.

Biological factors and statistical limitations prevent detection of most noncanonical proteins by mass spectrometry.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

Helical

Peptidase M13 N-terminal

Church D.M.
Goodstadt L.
Hillier L.W.
Zody M.C.
Goldstein S.
She X.
Bult C.J.
Agarwala R.
Cherry J.L.
DiCuccio M.
Hlavina W.
Kapustin Y.
Meric P.
Maglott D.
Birtle Z.
Marques A.C.
Graves T.
Zhou S.
Teague B.
Potamousis K.
Churas C.
Place M.
Herschleb J.
Runnheim R.
Forrest D.
Amos-Landgraf J.
Schwartz D.C.
Cheng Z.
Lindblad-Toh K.
Eichler E.E.
Ponting C.P.

Lineage-specific biology revealed by a finished genome assembly of the mouse.

Church D.M.
Schneider V.A.
Graves T.
Auger K.
Cunningham F.
Bouk N.
Chen H.C.
Agarwala R.
McLaren W.M.
Ritchie G.R.
Albracht D.
Kremitzki M.
Rock S.
Kotkiewicz H.
Kremitzki C.
Wollam A.
Trani L.
Fulton L.
Fulton R.
Matthews L.
Whitehead S.
Chow W.
Torrance J.
Dunn M.
Harden G.
Threadgold G.
Wood J.
Collins J.
Heath P.
Griffiths G.
Pelan S.
Grafham D.
Eichler E.E.
Weinstock G.
Mardis E.R.
Wilson R.K.
Howe K.
Flicek P.
Hubbard T.

Modernizing reference genome assemblies.

ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED

Metalloproteases ('zincins'), catalytic domain


Bacteria Bacillati Bacillota Bacilli Bacillales Paenibacillaceae Paenibacillus

Extracellular domain of a sensor histidine kinase NagS

Cache

Characterization of the extracellular domain of sensor histidine kinase NagS from Paenibacillus sp. str. FPU-7: nagS interacts with oligosaccharide binding protein NagB1 in complexes with N, N'-diacetylchitobiose.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Cervidae Cervinae Cervus

Disordered

Basic residues


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Helical

Disordered

Polar residues

Gly residues

Low complexity

Gly residues

Low complexity

Low complexity

Low complexity

Gly residues

Gly residues

Gly residues

Basic and acidic residues

Gly residues

Low complexity

Low complexity

COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Belongs to the protease inhibitor I19 family

Lacks conserved residue(s) required for the propagation of feature annotation

Protease inhibitor

Pacifastin

Pacifastin

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).

F:serine-type endopeptidase inhibitor activity


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose

a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose

an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose

Lipid metabolism; sphingolipid metabolism

Belongs to the glycosyl hydrolase 30 family

Glycosyl hydrolase family 30 TIM-barrel

Glycosyl hydrolase family 30 beta sandwich

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

P:negative regulation of cellular component organization

P:negative regulation of macromolecule metabolic process

P:positive regulation of protein metabolic process


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris


Eukaryota Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetidae Agaricales Tricholomatineae Entolomataceae Clitopilus

Mechanistic characterisation of the diterpene synthase for clitopilene and identification of isopentalenene synthase from the fungus Clitopilus passeckerianus.


MADS-box

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Apocynaceae Asclepiadoideae Marsdenieae Gymnema

Belongs to the disease resistance NB-LRR family

NB-ARC

Disease resistance protein At4g27190-like leucine-rich repeats

Transcriptomic revealing of plant pathogen interaction in Gymnema sylvestre.

Helical domain of apoptotic protease-activating factors

P-loop containing nucleotide triphosphate hydrolases

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

P-loop containing nucleoside triphosphate hydrolases


VWFA


Helical

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota
Metazoa
Spiralia
Lophotrochozoa
Annelida
Polychaeta
Errantia
Phyllodocida
Nereididae
Hediste
Hediste diversicolor species group

Belongs to the fatty acid desaturase type 1 family

Helical

Helical

Helical

Cytochrome b5 heme-binding

F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

Cytochrome b5-like heme/steroid binding domain


Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Dothideomycetes Pleosporomycetidae Pleosporales Pleosporineae Didymellaceae Didymella


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

Belongs to the argonaute family. Piwi subfamily

PAZ

Piwi

Disordered

Basic residues

Low complexity

Gly residues

Kostyuchenko R.P.
Nikanorova D.D.
Amosov A.V.

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.

P:regulatory ncRNA-mediated gene silencing

Ribonuclease H-like superfamily/Ribonuclease H

EUKARYOTIC TRANSLATION INITIATION FACTOR 2C


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Megalopygidae Megalopyge

Walker A.A.
Robinson S.D.
Merritt D.J.
Cardoso F.C.
Goudarzi M.H.
Mercedes R.S.
Eagles D.A.
Cooper P.
Zdenek C.N.
Fry B.G.
Hall D.W.
Vetter I.
King G.F.

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).

NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
SYNTHESIS OF 24-40
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Serine hydrolase-like protein isoform X1

AB hydrolase-1

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.

SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239


Eukaryota Fungi Dikarya Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces

Uncharacterized protein YFR035W-A

Helical

Murakami Y.
Naitou M.
Hagiwara H.
Shibata T.
Ozawa M.
Sasanuma S.
Sasanuma M.
Tsuchiya Y.
Soeda E.
Yokoyama K.
Yamazaki M.
Tashiro H.
Eki T.

Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae.

F:mitochondrion autophagosome adaptor activity

CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE


NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
RECOMBINANT EXPRESSION
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 1 profile

Rhodopsin 7-helix transmembrane proteins

ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR

Family A G protein-coupled receptor-like


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

K-box

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity


Helical

Helical

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Aculeata Apoidea Anthophila Apidae Xylocopa Koptortosoma

Toxin with weak activity on calcium-activated potassium (KCa) channels. Causes a small reversible block of human KCa2.1/KCNN1/SK1 and KCa2.2/KCNN2/SK2 (IC(50)=25.1 uM) currents

Negative results: does not show activity against Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA3. Does not elicit any spontaneous pain behaviors after intraplantar injection in mice

Alanine amide

Voltage-gated potassium channel impairing toxin

Shi N.
Szanto T.G.
He J.
Schroeder C.I.
Walker A.A.
Deuis J.R.
Vetter I.
Panyi G.
King G.F.
Robinson S.D.

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana.

NUCLEOTIDE SEQUENCE [MRNA]
PROTEIN SEQUENCE OF 32-54
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION
AMIDATION AT ALA-54
SYNTHESIS OF 32-54


Belongs to the peptidase S1 family. CLIP subfamily

Peptidase S1


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Hirudinea Hirudinida Hirudiniformes Hirudinidae Hirudo


DEAD-box RNA helicase Q

Helicase ATP-binding

Helicase C-terminal

Disordered

Disordered

Q motif

Basic and acidic residues

Pro residues

Low complexity

Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.

Probable ATP-dependent RNA helicase DDX4

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Solanales Solanaceae Solanoideae Physaleae Physalis

Belongs to the CLV3/ESR signal peptide family

Disordered

Editing multiple genes in Physalis pubescens provides implications for creating new germplasm and varieties of Physalis crops.

F:receptor serine/threonine kinase binding


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Mungall A.J.
Palmer S.A.
Sims S.K.
Edwards C.A.
Ashurst J.L.
Wilming L.
Jones M.C.
Horton R.
Hunt S.E.
Scott C.E.
Gilbert J.G.
Clamp M.E.
Bethel G.
Milne S.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Andrews T.D.
Ashwell R.I.
Babbage A.K.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beare D.M.
Beasley H.
Beasley O.
Bird C.P.
Blakey S.
Bray-Allen S.
Brook J.
Brown A.J.
Brown J.Y.
Burford D.C.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Clark S.Y.
Clark G.
Clee C.M.
Clegg S.
Cobley V.
Collier R.E.
Collins J.E.
Colman L.K.
Corby N.R.
Coville G.J.
Culley K.M.
Dhami P.
Davies J.
Dunn M.
Earthrowl M.E.
Ellington A.E.
Evans K.A.
Faulkner L.
Francis M.D.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Ghori M.J.
Gilby L.M.
Gillson C.J.
Glithero R.J.
Grafham D.V.
Grant M.
Gribble S.
Griffiths C.
Griffiths M.
Hall R.
Halls K.S.
Hammond S.
Harley J.L.
Hart E.A.
Heath P.D.
Heathcott R.
Holmes S.J.
Howden P.J.
Howe K.L.
Howell G.R.
Huckle E.
Humphray S.J.
Humphries M.D.
Hunt A.R.
Johnson C.M.
Joy A.A.
Kay M.
Keenan S.J.
Kimberley A.M.
King A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.R.
Lloyd D.M.
Loveland J.E.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Maslen G.L.
Matthews L.
McCann O.T.
McLaren S.J.
McLay K.
McMurray A.
Moore M.J.
Mullikin J.C.
Niblett D.
Nickerson T.
Novik K.L.
Oliver K.
Overton-Larty E.K.
Parker A.
Patel R.
Pearce A.V.
Peck A.I.
Phillimore B.
Phillips S.
Plumb R.W.
Porter K.M.
Ramsey Y.
Ranby S.A.
Rice C.M.
Ross M.T.
Searle S.M.
Sehra H.K.
Sheridan E.
Skuce C.D.
Smith S.
Smith M.
Spraggon L.
Squares S.L.
Steward C.A.
Sycamore N.
Tamlyn-Hall G.
Tester J.
Theaker A.J.
Thomas D.W.
Thorpe A.
Tracey A.
Tromans A.
Tubby B.
Wall M.
Wallis J.M.
West A.P.
White S.S.
Whitehead S.L.
Whittaker H.
Wild A.
Willey D.J.
Wilmer T.E.
Wood J.M.
Wray P.W.
Wyatt J.C.
Young L.
Younger R.M.
Bentley D.R.
Coulson A.
Durbin R.
Hubbard T.
Sulston J.E.
Dunham I.
Rogers J.
Beck S.

The DNA sequence and analysis of human chromosome 6.

Finishing the euchromatic sequence of the human genome.


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Disordered

Disordered

Low complexity

Low complexity

Gly residues

Low complexity

Basic and acidic residues


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Viperidae Crotalinae Protobothrops

Protocetin subunit alpha

Fan-Yu Z.
Ren-Sheng J.
Xiao-Qin Y.
Ya-Nan L.
Qi-Yun Z.
Qian-Yun S.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus


Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Sordariomycetes Sordariomycetidae Sordariales Chaetomiaceae Humicola

Fuscoatroside biosynthesis cluster protein D

Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the enfumafungin-type antibiotic, fuscoatroside (PubMed:38654452). Within the pathway, fsoD catalyzes the hydroxylation at position C2 of isomotiol to produce 2-alpha-hydroxy-isomotiol. FsoD may also hydroxylate the intermediates 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside at the same position C2 (PubMed:38654452). The fuscoatroside biosynthesis is initiated by the cyclization of 2,3(S)-oxidosqualene through FsoA's terpene cyclase (TC) domain, leading to the formation of the fernane skeleton isomotiol, harboring a fernane triterpene skeleton with a C8-C9 double bond. Subsequently, C2-alpha-hydroxylation mediated by fsoD results in the production of 2-alpha-hydroxy-isomotiol, which is further acetylated by fsoF. The glycosyltransferase (GT) domain of FsoA may convert isomotiol, 2-alpha-hydroxy-isomotiol, and the acetylated derivative of 2-alpha-hydroxy-isomotiol into their corresponding glycosides 3-O-(beta-D-glucopyranosyl)-isomotiol, 3-O-(beta-D-glucopyranosyl)-2-alpha-hydroxy-isomotiol, and 3-O-(beta-D-glucopyranosyl)-2-alpha-acetoxy-isomotiol, which then undergo oxidative cleavage under the action of fsoE to form s 2-deacetoxy-fuscoatroside, 2-deacetyl-fuscoatroside, and fuscoatroside, respectively. Although hydroxylation followed by acetylation of 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside by fsoD and fsoF could not be ruled out, this process is likely to occur with difficulty due to bulky steric hindrance caused by the presence of a glycan at C3 in these compounds. Interestingly, fsoE can also utilize the aglycones isomotiol and 2-alpha-hydroxy-isomotiol as substrates to generate 19-beta-hydroxy-isomotiol and 2-alpha,19-beta-dihydroxy-isomotiol, respectively. These reactions occur with lower efficiency. Finally, fsoE can further convert 2-alpha,19-beta-dihydroxy-isomotiol into 2-alpha-hydroxy-ismotiol-19-one and 2-alpha-hydroxy-ismotiol-19-one into 2-deacetyl-3-deglucopyranosyl-fuscoatroside (PubMed:38654452)

isomotiol + reduced [NADPH--hemoprotein reductase] + O2 = 2alpha-hydroxyisomotiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Secondary metabolite biosynthesis; terpenoid biosynthesis

Fuscoatroside and some of its derivatives show interesting antifungal activity against Candida albicans and Aspergillus niger

Cytochrome P450 monooxygenase fsoD

Helical

axial binding residue

Cao Z.Q.
Wang G.Q.
Luo R.
Gao Y.H.
Lv J.M.
Qin S.Y.
Chen G.D.
Awakawa T.
Bao X.F.
Mei Q.H.
Yao X.S.
Hu D.
Abe I.
Gao H.

Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C-C Bond Cleavage.

NUCLEOTIDE SEQUENCE [GENOMIC DNA]
FUNCTION
CATALYTIC ACTIVITY
PATHWAY
BIOTECHNOLOGY

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Apocynaceae Asclepiadoideae Marsdenieae Gymnema

Belongs to the disease resistance NB-LRR family

NB-ARC

Helical domain of apoptotic protease-activating factors

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain


Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Bacteria Bacillati Cyanobacteriota Cyanophyceae Oscillatoriophycideae Chroococcales Microcystaceae Pannus

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data

Response regulatory

Disordered

Machado M.
Botero N.B.
Andreote A.P.D.
Feitosa A.M.T.
Popin R.
Sivonen K.
Fiore M.F.

Genomic insights into the taxonomy and metabolism of the cyanobacterium Pannus brasiliensis CCIBt3594.

P:phosphorelay signal transduction system

RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Maruca


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Odorant binding protein/PBP-general odorant binding protein

Pheromone/general odorant binding protein domain


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Belongs to the glycosyl hydrolase 1 family

Disordered

Disordered

Polar residues

Basic and acidic residues


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

Truncated receptor-type tyrosine-protein phosphatase zeta transcript variant X1

Helical

Mouse RPTP-RPTP variants and expression.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Eupercaria Sciaenidae Argyrosomus

P:cellular response to lipopolysaccharide

P:positive regulation of gene expression

P:regulation of non-canonical NF-kappaB signal transduction


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

Tudor

Tudor

Tudor

Tudor

Disordered

Disordered

Low complexity


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Rhynchonelliformea Rhynchonellata Terebratellidina Laqueoidea Laqueidae Terebratalia

Helical

Dickkopf N-terminal cysteine-rich

Vellutini B.C.
Martin-Duran J.M.
Borve A.
Hejnol A.

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.

P:negative regulation of canonical Wnt signaling pathway

DICKKOPF N-TERMINAL CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion

Lacks conserved residue(s) required for the propagation of feature annotation

Helical

Helical

Disordered

Basic and acidic residues

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.

P:piecemeal microautophagy of the nucleus

P:protein localization to phagophore assembly site


Helical

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Disordered

Polar residues

P:homophilic cell adhesion via plasma membrane adhesion molecules


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Humphray S.J.
Oliver K.
Hunt A.R.
Plumb R.W.
Loveland J.E.
Howe K.L.
Andrews T.D.
Searle S.
Hunt S.E.
Scott C.E.
Jones M.C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Ashwell R.I.
Babbage A.K.
Babbage S.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beasley H.
Beasley O.
Bird C.P.
Bray-Allen S.
Brown A.J.
Brown J.Y.
Burford D.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Chen Y.
Clarke G.
Clark S.Y.
Clee C.M.
Clegg S.
Collier R.E.
Corby N.
Crosier M.
Cummings A.T.
Davies J.
Dhami P.
Dunn M.
Dutta I.
Dyer L.W.
Earthrowl M.E.
Faulkner L.
Fleming C.J.
Frankish A.
Frankland J.A.
French L.
Fricker D.G.
Garner P.
Garnett J.
Ghori J.
Gilbert J.G.
Glison C.
Grafham D.V.
Gribble S.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Guy J.
Hall R.E.
Hammond S.
Harley J.L.
Harrison E.S.
Hart E.A.
Heath P.D.
Henderson C.D.
Hopkins B.L.
Howard P.J.
Howden P.J.
Huckle E.
Johnson C.
Johnson D.
Joy A.A.
Kay M.
Keenan S.
Kershaw J.K.
Kimberley A.M.
King A.
Knights A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.
Lloyd D.M.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
McLaren S.
McLay K.E.
McMurray A.
Milne S.
Nickerson T.
Nisbett J.
Nordsiek G.
Pearce A.V.
Peck A.I.
Porter K.M.
Pandian R.
Pelan S.
Phillimore B.
Povey S.
Ramsey Y.
Rand V.
Scharfe M.
Sehra H.K.
Shownkeen R.
Sims S.K.
Skuce C.D.
Smith M.
Steward C.A.
Swarbreck D.
Sycamore N.
Tester J.
Thorpe A.
Tracey A.
Tromans A.
Thomas D.W.
Wall M.
Wallis J.M.
West A.P.
Whitehead S.L.
Willey D.L.
Williams S.A.
Wilming L.
Wray P.W.
Young L.
Ashurst J.L.
Coulson A.
Blocker H.
Durbin R.
Sulston J.E.
Hubbard T.
Jackson M.J.
Bentley D.R.
Beck S.
Rogers J.
Dunham I.

DNA sequence and analysis of human chromosome 9.


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Errantia Phyllodocida Nereididae Platynereis

Elongation of very long chain fatty acids protein

a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA

Helical

Helical

Helical

Helical

Helical

K Homology

Disordered

Disordered

Polar residues

Basic residues

P:fatty acid elongation, monounsaturated fatty acid

P:fatty acid elongation, polyunsaturated fatty acid

P:fatty acid elongation, saturated fatty acid

P:very long-chain fatty acid biosynthetic process

ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4

Eukaryotic type KH-domain (KH-domain type I)


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Clupei Clupeiformes Clupeoidei Clupeidae Tenualosa

Glycoprotein hormone subunit beta

Pathan M.A.
Dasgupta S.
Tripathi G.
Mitra P.
Misra A.
Pandey A.

Complete gene characterization of gonadotrophins in Tenualosa ilisha.


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Lobothelphusa

XlCGF8.2DB-like gastrula zinc finger protein

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

RB-associated KRAB zinc finger protein-like


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

K-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

WD repeat-containing protein 75-like protein

WD

WD

Disordered

Disordered

Disordered

Low complexity

Acidic residues

Basic and acidic residues

P:positive regulation of rRNA processing

P:positive regulation of transcription by RNA polymerase I

YVTN repeat-like/Quinoprotein amine dehydrogenase


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Echiura Xenopneusta Urechidae Urechis

Heat shock protein family A member 12 variant X1

Belongs to the heat shock protein 70 family

F:ATP-dependent protein folding chaperone


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Araneae Araneomorphae Entelegynae Lycosoidea Lycosidae Pardosa

NPC intracellular cholesterol transporter 2-like protein

MD-2-related lipid-recognition


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Heterogeneous nuclear ribonucleoprotein H1


Eukaryota Metazoa Spiralia Lophotrochozoa Bryozoa Phylactolaemata Pectinatellidae Pectinatella

PAS

PAS

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1


VWFA


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Odorant binding protein/PBP-general odorant binding protein

Pheromone/general odorant binding protein domain


Helical

Helical

Helical

Helical

K-box


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.

limulus clotting factor C

Peptidase S1

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Disordered

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Cole C.G.
McCann O.T.
Collins J.E.
Oliver K.
Willey D.
Gribble S.M.
Yang F.
McLaren K.
Rogers J.
Ning Z.
Beare D.M.
Dunham I.

Finishing the finished human chromosome 22 sequence.


Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues


Helical

Helical

Helical

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Paratelphusula

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Belongs to the glycosyl hydrolase 20 family

Glycoside hydrolase family 20 catalytic


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the UDP-glycosyltransferase family

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).


Bacteria Bacillati Cyanobacteriota Cyanophyceae Gloeobacterales Anthocerotibacteraceae Anthocerotibacter

Belongs to the phycobilisome linker protein family

PBS-linker

PBS-linker

PBS-linker

PBS-linker

PBS-linker

Jiang H.W.
Wu H.Y.
Wang C.H.
Yang C.H.
Ko J.T.
Ho H.C.
Tsai M.D.
Bryant D.A.
Li F.W.
Ho M.C.
Ho M.Y.

A structure of the relict phycobilisome from a thylakoid-free cyanobacterium.

STRUCTURE BY ELECTRON MICROSCOPY (3.07 ANGSTROMS)

C:plasma membrane-derived thylakoid membrane

PHYCOBILISOME 32.1 KDA LINKER POLYPEPTIDE, PHYCOCYANIN-ASSOCIATED, ROD 2-RELATED


Ligated ion channel binding I - glutamate

Helical

Helical

Helical

Helical


Helical

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN


Lacks conserved residue(s) required for the propagation of feature annotation

Helical

EGF-like

P:calcium ion import across plasma membrane


Heat shock protein family A member 12 variant X4

Belongs to the heat shock protein 70 family

F:ATP-dependent protein folding chaperone


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Lamiales Oleaceae Oleeae Syringa

Secondary metabolite biosynthesis; terpenoid biosynthesis

Belongs to the PC-esterase family. TBL subfamily

Terpene synthase N-terminal

Terpene synthase metal-binding

Trichome birefringence-like N-terminal

Trichome birefringence-like C-terminal


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Cephalopoda Coleoidea Octopodiformes Octopoda Incirrata Octopodidae Callistoctopus

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family

Biopterin-dependent aromatic amino acid hydroxylase family profile

Aromatic aminoacid monoxygenases, catalytic and oligomerization domains


Glycosyl transferase family 28 C-terminal


Belongs to the glycosyltransferase 31 family

Disordered

Low complexity

Basic and acidic residues


DOMON

Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Low complexity

Low complexity

Low complexity

Low complexity

Polar residues

Low complexity


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Protacanthopterygii Salmoniformes Salmonidae Salmoninae Salmo

Apoptosis-associated speck-like protein containing a CARD

CARD

Disordered

Polar residues

Acevedo-Castillo W.A.
Moran-Figueroa R.
Vargas-Chacoff L.
Morera F.J.
Pontigo J.P.

Revealing the Salmo salar NLRP3 Inflammasome: Insights from Structural Modeling and Transcriptome Analysis.

APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD

NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1


Disordered

Low complexity

Fernando A.
Liyanage C.
Moradi A.
Janaththani P.
Batra J.

Identification and Characterization of Alternatively Spliced Transcript Isoforms of IRX4 in Prostate Cancer.


Eukaryota Sar Alveolata Dinophyceae Gonyaulacales Lingulodiniaceae Lingulodinium

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Polar residues

Knockdown of Dinoflagellate Cellulose Synthase CesA1 Resulted in Malformed Intracellular Cellulosic Thecal Plates and Severely Impeded Cyst-to-Swarmer Transition.

Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A

CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

VWFA

Disordered

Low complexity


Eukaryota Metazoa Hemichordata Pterobranchia Cephalodiscida Cephalodiscidae Cephalodiscus

BHLH

PAS

PAS

Disordered

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

HLH, helix-loop-helix DNA-binding domain


Belongs to the UDP-glycosyltransferase family


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca


Lacks conserved residue(s) required for the propagation of feature annotation

CUB


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

P:positive regulation of transcription by RNA polymerase II


Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.


Helical

Ig-like

Fibronectin type-III

Disordered

Disordered

Disordered

Low complexity

Basic and acidic residues

Basic residues

Basic and acidic residues

Low complexity


Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

F:G protein-coupled serotonin receptor activity

P:adenylate cyclase-activating adrenergic receptor signaling pathway

Rhodopsin 7-helix transmembrane proteins

ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR

Family A G protein-coupled receptor-like


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Magnoliidae Piperales Asaraceae Asarum

Helical

axial binding residue


Eukaryota Discoba Euglenozoa Kinetoplastea Metakinetoplastina Trypanosomatida Trypanosomatidae Blastocrithidia

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix

Belongs to the cytochrome c oxidase subunit 3 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Heme-copper oxidase subunit III family profile

Cytochrome c oxidase, subunit III, four-helix bundle


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

Can bind about 5 Ca(2+) ions per subunit.

Helical

Peptidase metallopeptidase

Hemopexin

Hemopexin

Hemopexin

Hemopexin

Disordered

Pro residues

Phosphotyrosine; by PKDCC

Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.

MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED

Metalloproteases ('zincins'), catalytic domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Caelifera Acrididea Acridomorpha Acridoidea Acrididae Oedipodinae Locusta

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Disordered

Polar residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Polar residues

Basic and acidic residues

Polar residues

Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Chondrostei Acipenseriformes Acipenseridae Acipenser

Belongs to the alpha/beta interferon family


Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Megalopygidae Megalopyge

Walker A.A.
Robinson S.D.
Merritt D.J.
Cardoso F.C.
Goudarzi M.H.
Mercedes R.S.
Eagles D.A.
Cooper P.
Zdenek C.N.
Fry B.G.
Hall D.W.
Vetter I.
King G.F.

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).

NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
SYNTHESIS OF 30-40
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Epithelial sodium channel/degenerin-like protein

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
malvids
Myrtales
Myrtaceae
Myrtoideae
Myrteae
Pimenta group
Psidium

Terpene synthase N-terminal

Terpene synthase metal-binding

Canal D.
dos Santos P.H.D.
Carpinetti-Oliveira P.A.
Silva M.A.
Fernandes M.
Brustolini O.J.B.
Ferreira A.
Ferreira M.F.S.

Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.


Eukaryota Sar Stramenopiles Bigyra Labyrinthulomycetes Thraustochytrida Thraustochytriidae Schizochytrium

MRH

Disordered

Disordered

Low complexity

Polar residues

Basic and acidic residues

Acidic residues

Low complexity

Metabolism balance regulation for squalene production by disturbing triglycerides (TAG) synthesis in Schizochytrium sp.

P:endoplasmic reticulum unfolded protein response

P:retrograde protein transport, ER to cytosol

Mannose-6-phosphate receptor binding domain


MADS-box

Disordered

Basic residues

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding


Jacalin-type lectin

Jacalin-type lectin

PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN DWY1, CHLOROPLASTIC


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

Belongs to the type-B carboxylesterase/lipase family

Carboxylesterase type B

Disordered

Basic and acidic residues

Church D.M.
Goodstadt L.
Hillier L.W.
Zody M.C.
Goldstein S.
She X.
Bult C.J.
Agarwala R.
Cherry J.L.
DiCuccio M.
Hlavina W.
Kapustin Y.
Meric P.
Maglott D.
Birtle Z.
Marques A.C.
Graves T.
Zhou S.
Teague B.
Potamousis K.
Churas C.
Place M.
Herschleb J.
Runnheim R.
Forrest D.
Amos-Landgraf J.
Schwartz D.C.
Cheng Z.
Lindblad-Toh K.
Eichler E.E.
Ponting C.P.

Lineage-specific biology revealed by a finished genome assembly of the mouse.

Church D.M.
Schneider V.A.
Graves T.
Auger K.
Cunningham F.
Bouk N.
Chen H.C.
Agarwala R.
McLaren W.M.
Ritchie G.R.
Albracht D.
Kremitzki M.
Rock S.
Kotkiewicz H.
Kremitzki C.
Wollam A.
Trani L.
Fulton L.
Fulton R.
Matthews L.
Whitehead S.
Chow W.
Torrance J.
Dunn M.
Harden G.
Threadgold G.
Wood J.
Collins J.
Heath P.
Griffiths G.
Pelan S.
Grafham D.
Eichler E.E.
Weinstock G.
Mardis E.R.
Wilson R.K.
Howe K.
Flicek P.
Hubbard T.

Modernizing reference genome assemblies.


Tubulin/FtsZ GTPase

Disordered

Initial sequencing and analysis of the human genome.

Grimwood J.
Gordon L.A.
Olsen A.
Terry A.
Schmutz J.
Lamerdin J.
Hellsten U.
Goodstein D.
Couronne O.
Tran-Gyamfi M.
Aerts A.
Altherr M.
Ashworth L.
Bajorek E.
Black S.
Branscomb E.
Caenepeel S.
Carrano A.
Caoile C.
Chan Y.M.
Christensen M.
Cleland C.A.
Copeland A.
Dalin E.
Dehal P.
Denys M.
Detter J.C.
Escobar J.
Flowers D.
Fotopulos D.
Garcia C.
Georgescu A.M.
Glavina T.
Gomez M.
Gonzales E.
Groza M.
Hammon N.
Hawkins T.
Haydu L.
Ho I.
Huang W.
Israni S.
Jett J.
Kadner K.
Kimball H.
Kobayashi A.
Larionov V.
Leem S.H.
Lopez F.
Lou Y.
Lowry S.
Malfatti S.
Martinez D.
McCready P.
Medina C.
Morgan J.
Nelson K.
Nolan M.
Ovcharenko I.
Pitluck S.
Pollard M.
Popkie A.P.
Predki P.
Quan G.
Ramirez L.
Rash S.
Retterer J.
Rodriguez A.
Rogers S.
Salamov A.
Salazar A.
She X.
Smith D.
Slezak T.
Solovyev V.
Thayer N.
Tice H.
Tsai M.
Ustaszewska A.
Vo N.
Wagner M.
Wheeler J.
Wu K.
Xie G.
Yang J.
Dubchak I.
Furey T.S.
DeJong P.
Dickson M.
Gordon D.
Eichler E.E.
Pennacchio L.A.
Richardson P.
Stubbs L.
Rokhsar D.S.
Myers R.M.
Rubin E.M.
Lucas S.M.

The DNA sequence and biology of human chromosome 19.

Finishing the euchromatic sequence of the human genome.


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Sabellida Siboglinidae Osedax

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Disordered

Disordered

Polar residues

Basic and acidic residues

Gly residues

Tilic E.
Miyamoto N.
Herranz M.
Worsaae K.

Hooked on zombie worms? Genetic blueprints of bristle formation in Osedax japonicus (Annelida).


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
fabids
Fabales
Fabaceae
Papilionoideae
50 kb inversion clade
NPAAA clade
indigoferoid/millettioid clade
Millettieae
Pongamia

Disordered

Polar residues

Transcripts identified in leaf tissues of Pongamia pinnata at the University of Delhi, India.


Eukaryota Metazoa Echinodermata Eleutherozoa Echinozoa Holothuroidea Aspidochirotacea Aspidochirotida Stichopodidae Apostichopus

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family

GB1/RHD3-type G

Guanylate-binding protein, C-terminal domain

P-loop containing nucleotide triphosphate hydrolases

Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

RPEL

RPEL

SAP

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Basic and acidic residues

Polar residues

Basic and acidic residues

Low complexity

Polar residues

Basic residues

Basic and acidic residues

Basic and acidic residues

Pro residues

Mikhailov K.
Kravchuk O.
Lyupina Y.
Adameyko K.

P:positive regulation of transcription by RNA polymerase II

MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H


After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily

Helical

Helical

Helical

Helical

Disordered

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

F:acetylcholine-gated monoatomic cation-selective channel activity

F:transmembrane signaling receptor activity

Acetylcholine receptor subunit alpha-like

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like


Disordered

Disordered

Basic and acidic residues

Acidic residues


Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Proprotein convertase subtilisin/kexin type 9

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Hirudinea Hirudinida Hirudiniformes Hirudinidae Hirudo

SCP domain-containing protein

SCP


Receptor-type tyrosine-protein phosphatase-like protein

O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Helical

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Tyrosine-protein phosphatase

Tyrosine specific protein phosphatases

Tyrosine-protein phosphatase

Tyrosine specific protein phosphatases

Disordered

Polar residues

Protein tyrosine phosphatase superfamily

(Phosphotyrosine protein) phosphatases II


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Lacks conserved residue(s) required for the propagation of feature annotation

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).

F:transmembrane receptor protein tyrosine kinase activator activity


Disordered

Disordered

Low complexity


Disordered

6-Phosphogluconate Dehydrogenase, domain 3


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Echiura Xenopneusta Urechidae Urechis

Fork-head

Fork-head

Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Basic and acidic residues

Low complexity

Low complexity

Low complexity

Polar residues

Low complexity

Polar residues

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Scorpiones Iurida Chactoidea Euscorpiidae Scorpiopinae Scorpiopini Euscorpiops

Probable antimicrobial peptide. Has no inhibitory activity against herpes simplex virus type 1 (HSV-1)

Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family

Antimicrobial peptide Eval967

Leucine amide

Zeng Z.
Zhang R.
Hong W.
Cheng Y.
Wang H.
Lang Y.
Ji Z.
Wu Y.
Li W.
Xie Y.
Cao Z.

Histidine-rich modification of a scorpion-derived peptide improves bioavailability and inhibitory activity against HSV-1.

NUCLEOTIDE SEQUENCE [MRNA]
SYNTHESIS OF 23-36
PROBABLE AMIDATION AT LEU-36


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical


Helical

P-type

Disordered

Disordered

Disordered

Low complexity

Polar residues

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Zody M.C.
Garber M.
Adams D.J.
Sharpe T.
Harrow J.
Lupski J.R.
Nicholson C.
Searle S.M.
Wilming L.
Young S.K.
Abouelleil A.
Allen N.R.
Bi W.
Bloom T.
Borowsky M.L.
Bugalter B.E.
Butler J.
Chang J.L.
Chen C.K.
Cook A.
Corum B.
Cuomo C.A.
de Jong P.J.
DeCaprio D.
Dewar K.
FitzGerald M.
Gilbert J.
Gibson R.
Gnerre S.
Goldstein S.
Grafham D.V.
Grocock R.
Hafez N.
Hagopian D.S.
Hart E.
Norman C.H.
Humphray S.
Jaffe D.B.
Jones M.
Kamal M.
Khodiyar V.K.
LaButti K.
Laird G.
Lehoczky J.
Liu X.
Lokyitsang T.
Loveland J.
Lui A.
Macdonald P.
Major J.E.
Matthews L.
Mauceli E.
McCarroll S.A.
Mihalev A.H.
Mudge J.
Nguyen C.
Nicol R.
O'Leary S.B.
Osoegawa K.
Schwartz D.C.
Shaw-Smith C.
Stankiewicz P.
Steward C.
Swarbreck D.
Venkataraman V.
Whittaker C.A.
Yang X.
Zimmer A.R.
Bradley A.
Hubbard T.
Birren B.W.
Rogers J.
Lander E.S.
Nusbaum C.

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.


Eukaryota Metazoa Porifera Demospongiae Heteroscleromorpha Poecilosclerida Hymedesmiidae Kirkpatrickia

Disordered

Disordered

Low complexity

Low complexity

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding


Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family

Protein kinase

Disordered

Qin Z.
Yang J.
Zhang K.
Gao X.
Ran Q.
Xu Y.
Wang Z.
Lou D.
Huang C.
Zellmer L.
Meng G.
Chen N.
Ma H.
Wang Z.
Liao D.J.

Updating mRNA variants of the human RSK4 gene and their expression in different stressed situations.

Qin Z.W.
Yang J.L.
Zhang K.Y.
Gao X.
Ran Q.C.
Xu Y.H.
Wang Z.
Lou D.D.
Huang C.H.
Zellmer L.
Meng G.X.
Chen N.
Ma H.
Wang Z.
Liao D.J.

F:protein serine/threonine kinase activity


Eukaryota Metazoa Spiralia Lophotrochozoa Platyhelminthes Rhabditophora Seriata Tricladida Continenticola Geoplanoidea Dugesiidae Dugesia

VWFA

VWFA

Identification of a collagen alpha-4 like gene in planarian Dugesia japonica.


Helical

Disordered

Polar residues

Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team

Scherer S.E.
Muzny D.M.
Buhay C.J.
Chen R.
Cree A.
Ding Y.
Dugan-Rocha S.
Gill R.
Gunaratne P.
Harris R.A.
Hawes A.C.
Hernandez J.
Hodgson A.V.
Hume J.
Jackson A.
Khan Z.M.
Kovar-Smith C.
Lewis L.R.
Lozado R.J.
Metzker M.L.
Milosavljevic A.
Miner G.R.
Montgomery K.T.
Morgan M.B.
Nazareth L.V.
Scott G.
Sodergren E.
Song X.Z.
Steffen D.
Lovering R.C.
Wheeler D.A.
Worley K.C.
Yuan Y.
Zhang Z.
Adams C.Q.
Ansari-Lari M.A.
Ayele M.
Brown M.J.
Chen G.
Chen Z.
Clerc-Blankenburg K.P.
Davis C.
Delgado O.
Dinh H.H.
Draper H.
Gonzalez-Garay M.L.
Havlak P.
Jackson L.R.
Jacob L.S.
Kelly S.H.
Li L.
Li Z.
Liu J.
Liu W.
Lu J.
Maheshwari M.
Nguyen B.V.
Okwuonu G.O.
Pasternak S.
Perez L.M.
Plopper F.J.
Santibanez J.
Shen H.
Tabor P.E.
Verduzco D.
Waldron L.
Wang Q.
Williams G.A.
Zhang J.
Zhou J.
Allen C.C.
Amin A.G.
Anyalebechi V.
Bailey M.
Barbaria J.A.
Bimage K.E.
Bryant N.P.
Burch P.E.
Burkett C.E.
Burrell K.L.
Calderon E.
Cardenas V.
Carter K.
Casias K.
Cavazos I.
Cavazos S.R.
Ceasar H.
Chacko J.
Chan S.N.
Chavez D.
Christopoulos C.
Chu J.
Cockrell R.
Cox C.D.
Dang M.
Dathorne S.R.
David R.
Davis C.M.
Davy-Carroll L.
Deshazo D.R.
Donlin J.E.
D'Souza L.
Eaves K.A.
Egan A.
Emery-Cohen A.J.
Escotto M.
Flagg N.
Forbes L.D.
Gabisi A.M.
Garza M.
Hamilton C.
Henderson N.
Hernandez O.
Hines S.
Hogues M.E.
Huang M.
Idlebird D.G.
Johnson R.
Jolivet A.
Jones S.
Kagan R.
King L.M.
Leal B.
Lebow H.
Lee S.
LeVan J.M.
Lewis L.C.
London P.
Lorensuhewa L.M.
Loulseged H.
Lovett D.A.
Lucier A.
Lucier R.L.
Ma J.
Madu R.C.
Mapua P.
Martindale A.D.
Martinez E.
Massey E.
Mawhiney S.
Meador M.G.
Mendez S.
Mercado C.
Mercado I.C.
Merritt C.E.
Miner Z.L.
Minja E.
Mitchell T.
Mohabbat F.
Mohabbat K.
Montgomery B.
Moore N.
Morris S.
Munidasa M.
Ngo R.N.
Nguyen N.B.
Nickerson E.
Nwaokelemeh O.O.
Nwokenkwo S.
Obregon M.
Oguh M.
Oragunye N.
Oviedo R.J.
Parish B.J.
Parker D.N.
Parrish J.
Parks K.L.
Paul H.A.
Payton B.A.
Perez A.
Perrin W.
Pickens A.
Primus E.L.
Pu L.L.
Puazo M.
Quiles M.M.
Quiroz J.B.
Rabata D.
Reeves K.
Ruiz S.J.
Shao H.
Sisson I.
Sonaike T.
Sorelle R.P.
Sutton A.E.
Svatek A.F.
Svetz L.A.
Tamerisa K.S.
Taylor T.R.
Teague B.
Thomas N.
Thorn R.D.
Trejos Z.Y.
Trevino B.K.
Ukegbu O.N.
Urban J.B.
Vasquez L.I.
Vera V.A.
Villasana D.M.
Wang L.
Ward-Moore S.
Warren J.T.
Wei X.
White F.
Williamson A.L.
Wleczyk R.
Wooden H.S.
Wooden S.H.
Yen J.
Yoon L.
Yoon V.
Zorrilla S.E.
Nelson D.
Kucherlapati R.
Weinstock G.
Gibbs R.A.
null.

The finished DNA sequence of human chromosome 12.

Serine/threonine-protein kinase receptor R3


ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Megalopygidae Megalopyge

Walker A.A.
Robinson S.D.
Merritt D.J.
Cardoso F.C.
Goudarzi M.H.
Mercedes R.S.
Eagles D.A.
Cooper P.
Zdenek C.N.
Fry B.G.
Hall D.W.
Vetter I.
King G.F.

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Microhyloidea Microhylidae Dyscophinae Dyscophus

Galectin

Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.

P:negative regulation of CD4-positive, alpha-beta T cell proliferation

P:negative regulation of type II interferon production

P:positive regulation of gene expression


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pentatomoidea Pentatomidae Asopinae Eocanthecona

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Ligated ion channel binding I - glutamate

Helical

Helical

Helical


Eukaryota
Fungi
Fungi incertae sedis
Microsporidia
Pereziidae
Ameson


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.

Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Tityus

Presents weak hemolytic activity at physiological concentrations (micromolar range), and weak lactate dehydrogenase (LDH) release from mast cells. Does not induce mast cell degranulation, and antimicrobial effects. In vivo, injection into mice induces very weak or no change in nociceptive sensibility, and very reduced or no edema formation. It also reduces mice locomotion, suggesting an increase in anxiety, but causes no alteration in rearing (standing on hind limbs)

Cryptide Pep-2

Dias N.B.
de Souza B.M.
Cocchi F.K.
Chalkidis H.M.
Dorce V.A.C.
Palma M.S.

Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.

PROTEIN SEQUENCE
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION
SYNTHESIS
FUNCTION
BIOASSAY


Stylosanthes guianensis subsp. guianensis

Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
fabids
Fabales
Fabaceae
Papilionoideae
50 kb inversion clade
dalbergioids sensu lato
Dalbergieae
Pterocarpus clade
Stylosanthes

BHLH

Disordered

Low complexity

Wang W.
Zhang Z.S.
Yang Y.L.
Luo L.L.
Jiang J.L.

SPERMATOGENESIS- AND OOGENESIS-SPECIFIC BASIC HELIX-LOOP-HELIX-CONTAINING PROTEIN 1

HLH, helix-loop-helix DNA-binding domain


Eukaryota Metazoa Spiralia Lophotrochozoa Phoronida Phoronidae Phoronopsis

BHLH

PAS

PAS

Disordered

Disordered

Basic and acidic residues

Basic and acidic residues

F:DNA-binding transcription factor activity, RNA polymerase II-specific

Hypoxia-inducible factor 1 subunit alpha

Hypoxia-inducible factor 1-alpha isoform 1


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca


Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)

Bacteria Bacillati Actinomycetota Actinomycetes Mycobacteriales Mycobacteriaceae Mycolicibacterium

Probable antitoxin component of a type II toxin-antitoxin (TA) system. The probable cognate antitoxin is PhoAT; the toxin gene can be expressed in the absence of the antitoxin gene in M.smegmatis strain mc(2)155 (PubMed:25999286)

Interacts with toxin PhoH2 (PubMed:25999286)

Part of the phoAT-phoH2 operon (PubMed:25999286)

Deletion of the phoAT-phoH2 genes has no visible growth phenotype (PubMed:25999286)

Probable antitoxin PhoAT

Fleischmann R.D.
Dodson R.J.
Haft D.H.
Merkel J.S.
Nelson W.C.
Fraser C.M.

Deshayes C.
Perrodou E.
Gallien S.
Euphrasie D.
Schaeffer C.
Van-Dorsselaer A.
Poch O.
Lecompte O.
Reyrat J.-M.

Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?

Gallien S.
Perrodou E.
Carapito C.
Deshayes C.
Reyrat J.-M.
Van Dorsselaer A.
Poch O.
Schaeffer C.
Lecompte O.

Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol.

The mycobacterial PhoH2 proteins are type II toxin antitoxins coupled to RNA helicase domains.

IDENTIFICATION BY MASS SPECTROMETRY
FUNCTION
SUBUNIT
OPERON STRUCTURE
DISRUPTION PHENOTYPE


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

S S.B.
Negi N.
Nagarjuna Reddy K.
R G.G.

Takout-proteins of Maconellicoccus hirsutus.

Haemolymph juvenile hormone binding protein


Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo


Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 3 profile

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

C:G protein-coupled receptor heterodimeric complex

F:G protein-coupled GABA receptor activity

P:gamma-aminobutyric acid signaling pathway

Gamma-aminobutyric acid type B receptor subunit 2

GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2


May function as a large pore-forming protein

Histidine amide

NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
PROBABLE AMIDATION AT HIS-284
3D-STRUCTURE MODELING
RECOMBINANT EXPRESSION
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


NIDO

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

P:homophilic cell adhesion via plasma membrane adhesion molecules


Belongs to the UDP-glycosyltransferase family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Lacks conserved residue(s) required for the propagation of feature annotation

CUB

Disordered

Basic and acidic residues


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Disordered

Low complexity

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).