Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Disordered

Pro residues

Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Paf1 complex subunit Cdc73 N-terminal

A novel Pathogenic CDC73 Gene Variant in Hyperparathyroidism Jaw Tumor Syndrome.


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Lycopodiopsida Lycopodiales Lycopodiaceae Huperzioideae Huperzia

Belongs to the AP2/ERF transcription factor family. AP2 subfamily

Disordered

Disordered

Lei M.
Li C.
Zhang Z.-j.
Ou X.-l.
Chen X.-y.

F:DNA-binding transcription factor activity

AP2-like ethylene-responsive transcription factor

AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR

ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR RAP2-7


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Disordered

Polar residues

Crucial to convey clamshell closure to channel opening

Interaction with the cone snail toxin Con-ikot-ikot

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

F:transmitter-gated monoatomic ion channel activity

P:cell surface receptor signaling pathway

Eye-enriched kainate receptor, isoform B

Glutamate receptor ionotropic, kainate 1

Glutamate receptor ionotropic, kainate 2

Putative glutamate receptor ionotropic kainate 1


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
malvids
Myrtales
Myrtaceae
Myrtoideae
Myrteae
Pimenta group
Psidium

Terpene synthase N-terminal

Canal D.
dos Santos P.H.D.
Carpinetti-Oliveira P.A.
Silva M.A.
Fernandes M.
Brustolini O.J.B.
Ferreira A.
Ferreira M.F.S.

Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Disordered


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Deleted in malignant brain tumors 1 protein-like protein 2

Lacks conserved residue(s) required for the propagation of feature annotation

SRCR

SRCR

SRCR

Ig-like

Ig-like

Protein kinase

Ig-like

DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED


Structure-specific endonuclease subunit SLX4

Helical

Helical

Helical

Helical

BTB

Disordered

Disordered

Disordered

Disordered

Disordered

Basic residues

Polar residues

Polar residues

P:resolution of meiotic recombination intermediates

STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Helical

Helical

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.


Family with sequence similarity 136 member A

Disordered

Basic and acidic residues

International Human Genome Sequencing Consortium

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.


Metabotropic glutamate receptor-like protein

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors

Belongs to the G-protein coupled receptor 3 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 3 profile

Disordered

Disordered

Disordered

Polar residues

Low complexity

Polar residues

P:phospholipase C-activating G protein-coupled glutamate receptor signaling pathway


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Ranunculales Papaveraceae Fumarioideae Corydalis

Helical

axial binding residue

P:isoquinoline alkaloid biosynthetic process


Helical


Reverse transcriptase domain-containing protein

Disordered

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Polar residues

Polar residues

Basic and acidic residues

Low complexity

REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN

REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN


Helical

Helical

Helical

Helical

Helical

Helical

Helical


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

K-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity


Epithelial sodium channel/degenerin-like protein

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family

Helical

Disordered

Polar residues


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Errantia Eunicida Dorvilleidae Ophryotrocha

Lacks conserved residue(s) required for the propagation of feature annotation

Helical

VWFD

Filamin

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

SEA

EGF-like

D or N

Latent-transforming growth factor beta-binding protein 3


Ig-like

Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Diptera Brachycera Muscomorpha Oestroidea Sarcophagidae Sarcophaga Pandelleisca

Expression of genes involved in ecdysteroidogenesis in relation to pupal diapause entry in the flesh fly Sarcophaga similis.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Helical

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Sabellida Siboglinidae Ridgeia

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data

Ig-like domain-containing protein

Ig-like

Perez M.
Aroh O.
Sun Y.
Lan Y.
Juniper S.K.
Young C.R.
Angers B.
Qian P.Y.

Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.


Helical

Ig-like

Disordered

Disordered

Polar residues

CARTILAGE INTERMEDIATE LAYER PROTEIN 1-LIKE ISOFORM X1

CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

SCP

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Belongs to the peptidase S1 family. CLIP subfamily

Peptidase S1


Peptidase S1


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pentatomoidea Pentatomidae Asopinae Arma

Belongs to the Toll-like receptor family

Helical

TIR

Disordered

Polar residues

miR-8 maintains the immune homeostasis of Arma chinensis Fallou by inhibiting AcMNPV's essential genes and regulating the innate immune response in host insect.

F:transmembrane signaling receptor activity

Toll/interleukin-1 receptor homology (TIR) domain


Fork-head

Fork-head

Disordered

Polar residues

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

RNase L inhibitor RLI-like possible metal-binding

Disordered

Church D.M.
Goodstadt L.
Hillier L.W.
Zody M.C.
Goldstein S.
She X.
Bult C.J.
Agarwala R.
Cherry J.L.
DiCuccio M.
Hlavina W.
Kapustin Y.
Meric P.
Maglott D.
Birtle Z.
Marques A.C.
Graves T.
Zhou S.
Teague B.
Potamousis K.
Churas C.
Place M.
Herschleb J.
Runnheim R.
Forrest D.
Amos-Landgraf J.
Schwartz D.C.
Cheng Z.
Lindblad-Toh K.
Eichler E.E.
Ponting C.P.

Lineage-specific biology revealed by a finished genome assembly of the mouse.

Church D.M.
Schneider V.A.
Graves T.
Auger K.
Cunningham F.
Bouk N.
Chen H.C.
Agarwala R.
McLaren W.M.
Ritchie G.R.
Albracht D.
Kremitzki M.
Rock S.
Kotkiewicz H.
Kremitzki C.
Wollam A.
Trani L.
Fulton L.
Fulton R.
Matthews L.
Whitehead S.
Chow W.
Torrance J.
Dunn M.
Harden G.
Threadgold G.
Wood J.
Collins J.
Heath P.
Griffiths G.
Pelan S.
Grafham D.
Eichler E.E.
Weinstock G.
Mardis E.R.
Wilson R.K.
Howe K.
Flicek P.
Hubbard T.

Modernizing reference genome assemblies.

F:rRNA small subunit aminocarboxypropyltransferase activity

RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG


Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Helical

Selvamani S.B.
Negi N.
Nagarjun Reddy K.
Ramasamy G.G.

Partial mRNA sequence of CYP3638E1 from Maconellicoccus hirsutus (Green).


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Nusbaum C.
Zody M.C.
Borowsky M.L.
Kamal M.
Kodira C.D.
Taylor T.D.
Whittaker C.A.
Chang J.L.
Cuomo C.A.
Dewar K.
FitzGerald M.G.
Yang X.
Abouelleil A.
Allen N.R.
Anderson S.
Bloom T.
Bugalter B.
Butler J.
Cook A.
DeCaprio D.
Engels R.
Garber M.
Gnirke A.
Hafez N.
Hall J.L.
Norman C.H.
Itoh T.
Jaffe D.B.
Kuroki Y.
Lehoczky J.
Lui A.
Macdonald P.
Mauceli E.
Mikkelsen T.S.
Naylor J.W.
Nicol R.
Nguyen C.
Noguchi H.
O'Leary S.B.
O'Neill K.
Piqani B.
Smith C.L.
Talamas J.A.
Topham K.
Totoki Y.
Toyoda A.
Wain H.M.
Young S.K.
Zeng Q.
Zimmer A.R.
Fujiyama A.
Hattori M.
Birren B.W.
Sakaki Y.
Lander E.S.

DNA sequence and analysis of human chromosome 18.


IgG Fc fragment receptor transporter alpha chain

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB

FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer. Interacts with albumin/ALB; this interaction regulates ALB homeostasis

Belongs to the immunoglobulin superfamily

IgG receptor FcRn large subunit p51

Ig-like

Disordered

Low complexity

Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.


Disordered

Basic residues

P-loop containing nucleotide triphosphate hydrolases

RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY

P-loop containing nucleoside triphosphate hydrolases


Helical

Helical

Helical


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

RRM

Disordered

Polar residues

Kostyuchenko R.P.
Nikanorova D.D.
Amosov A.V.

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.

P:positive regulation of translational initiation


Odorant binding protein/PBP-general odorant binding protein

Pheromone/general odorant binding protein domain


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Bifunctional 3-dehydroquinate dehydratase shikimate dehydrogenase

F:shikimate 3-dehydrogenase (NADP+) activity

BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC


Adhesion G protein-coupled receptor L3-like protein

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Disordered

Disordered

Polar residues

Polar residues

Basic and acidic residues

Polar residues

Rhodopsin 7-helix transmembrane proteins


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Pinopsida
Pinidae
Conifers I
Pinales
Pinaceae
Pinus
Pinus subgen. Pinus

PAZ

RNase III

RNase III

DRBM

Identification of RNAi-Related Genes and Transcriptome Assembly of Loblolly Pine (Pinus taeda, L.) Seedlings Exposed to Insect-Specific dsRNA.


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Rhynchonelliformea Rhynchonellata Terebratellidina Laqueoidea Laqueidae Terebratalia

Belongs to the secreted frizzled-related protein (sFRP) family

Lacks conserved residue(s) required for the propagation of feature annotation

FZ

NTR

Disordered

Basic residues

Vellutini B.C.
Martin-Duran J.M.
Borve A.
Hejnol A.

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 1 profile

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

P:adenylate cyclase-activating adrenergic receptor signaling pathway

ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR

Family A G protein-coupled receptor-like


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Characiformes Characoidei Acestrorhamphidae Acestrorhamphinae Astyanax

Nuclear receptor

Molecular and hormonal mechanisms underlying oocyte maturation and ovulation and its application to seed production in the lambari (Astyanax altiparanae).

F:DNA-binding transcription factor activity

Erythroid Transcription Factor GATA-1, subunit A

Glucocorticoid receptor-like (DNA-binding domain)


Cystatin

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).

F:cysteine-type endopeptidase inhibitor activity


Belongs to the argonaute family. Piwi subfamily

PAZ

Piwi

Disordered

Low complexity

Low complexity

P:regulatory ncRNA-mediated gene silencing

Ribonuclease H-like superfamily/Ribonuclease H

EUKARYOTIC TRANSLATION INITIATION FACTOR 2C


Belongs to the UDP-glycosyltransferase family


Disordered

Basic and acidic residues

Cole C.G.
McCann O.T.
Collins J.E.
Oliver K.
Willey D.
Gribble S.M.
Yang F.
McLaren K.
Rogers J.
Ning Z.
Beare D.M.
Dunham I.

Finishing the finished human chromosome 22 sequence.


Helical

Glycosyl transferase family 28 C-terminal


Bacteria Pseudomonadati Pseudomonadota Alphaproteobacteria Rickettsiales Lyticum

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner

Hydrolysis of proteins in presence of ATP.

Homohexamer. Organized in a ring with a central cavity

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data

Lon N-terminal

Lon proteolytic

Castelli M.
Nardi T.
Gammuto L.
Bellinzona G.
Sabaneyeva E.
Potekhin A.
Serra V.
Petroni G.
Sassera D.

Host association and intracellularity evolved multiple times independently in the Rickettsiales.

P:protein quality control for misfolded or incompletely synthesized proteins

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Aplacophora Solenogastres Cavibelonia Amphimeniidae Alexandromenia

PAS

Disordered

Disordered

Disordered

Basic and acidic residues

Basic and acidic residues

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Bivalvia Autobranchia Pteriomorphia Pterioida Pterioidea Pteriidae Pinctada

Lacks conserved residue(s) required for the propagation of feature annotation

Integrase catalytic

ShKT

BPTI/Kunitz inhibitor

Disordered

Disordered

Disordered

Polar residues

Low complexity

Polar residues

The improved chromosome-level genome for the pearl oyster Pinctada fucata martensii using PacBio sequencing and Hi-C.

F:serine-type endopeptidase inhibitor activity

Retrovirus-related Pol polyprotein from transposon 297-like Protein

Retrovirus-related Pol polyprotein from transposon gypsy-like Protein

Pancreatic trypsin inhibitor Kunitz domain

ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED

Retrovirus capsid dimerization domain-like


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Disordered

Polar residues

Polar residues


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos

ACB

Disordered

Low complexity

Moore S.
Alexander L.
Brownstein M.
Guan L.
Lobo S.
Meng Y.
Tanaguchi M.
Wang Z.
Yu J.
Prange C.
Schreiber K.
Shenmen C.
Wagner L.
Bala M.
Barbazuk S.
Barber S.
Babakaiff R.
Beland J.
Chun E.
Del Rio L.
Gibson S.
Hanson R.
Kirkpatrick R.
Liu J.
Matsuo C.
Mayo M.
Santos R.R.
Stott J.
Tsai M.
Wong D.
Siddiqui A.
Holt R.
Jones S.J.
Marra M.A.

Rosen B.D.
Bickhart D.M.
Koren S.
Schnabel R.D.
Hall R.
Zimin A.
Dreischer C.
Schultheiss S.
Schroeder S.G.
Elsik C.G.
Couldrey C.
Liu G.E.
Van Tassell C.P.
Phillippy A.M.
Smith T.P.L.
Medrano J.F.

ARS-UCD1.2.

Expressed in corpus luteum and 104 other cell types or tissues

Enoyl-CoA delta isomerase 2, mitochondrial

2-enoyl-CoA Hydratase, Chain A, domain 1


F-box

PDZ


Muscrinic acethylcholine receptor-like GPCR protein

Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Disordered

Disordered

Disordered

Low complexity

Low complexity

Polar residues

Polar residues

Basic and acidic residues

Polar residues

Basic and acidic residues

F:G protein-coupled acetylcholine receptor activity

F:G protein-coupled serotonin receptor activity

P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Rhodopsin 7-helix transmembrane proteins

MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A

Family A G protein-coupled receptor-like


Centromere-associated protein E-like protein

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family

Kinesin motor

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Acidic residues

Basic and acidic residues

Basic and acidic residues

Polar residues

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Aplacophora Solenogastres Pholidoskepia Macellomeniidae Macellomenia

BHLH

PAS

PAS

Disordered

Disordered

Basic residues

Basic and acidic residues

Polar residues

Low complexity

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Caridea Palaemonoidea Palaemonidae Macrobrachium

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

USP

Disordered

Disordered

Disordered

Disordered

Disordered

Low complexity

Polar residues

Low complexity

Basic and acidic residues

Polar residues

Basic and acidic residues

Basic and acidic residues

Acidic residues

Low complexity

Polar residues

Polar residues

Basic and acidic residues

Low complexity

UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Helical

Helical

Helical

Helical

Helical

Helical

Helical


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Liliopsida Asparagales Asparagaceae Agavoideae Agave

SBP-type

Disordered

Basic residues

Hernandez-Soriano L.
Galvez-Sandre L.
Avila De Dios E.
Simpson J.

How to awaken a sleeping giant: antagonistic expression of flowering locus T homologs and elements of the age related pathway are associated with the flowering transition in Agave tequilana.

SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 4

SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 7


Eukaryota
Viridiplantae
Chlorophyta
core chlorophytes
Chlorophyceae
CS clade
Chlamydomonadales
Dunaliellaceae
Dunaliella

Divalent metal cations. Prefers magnesium or manganese.

Helical

Malic enzyme N-terminal

Proton donor

Proton acceptor

Combined Effects of Nitrogen Limitation and Overexpression of Malic Enzyme Gene on Lipid Accumulation in Dunaliella parva.

F:malate dehydrogenase (decarboxylating) (NADP+) activity

Aminoacid dehydrogenase-like, N-terminal domain


Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Helical

Ionotropic glutamate receptor C-terminal

Ionotropic glutamate receptor L-glutamate and glycine-binding

F:ligand-gated monoatomic ion channel activity

glutamate receptor ionotropic, NMDA 1 isoform X1

Putative glutamate receptor ionotropic NMDA 2B


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo


Bacteria Pseudomonadati Pseudomonadota Gammaproteobacteria Vibrionales Vibrionaceae Vibrio

Gruschow S.
McQuarrie S.
Ackermann K.
McMahon S.
Bode B.E.
Gloster T.M.
White M.F.

CRISPR antiphage defence mediated by the cyclic nucleotide-binding membrane protein Csx23.


Disordered

Disordered

Basic and acidic residues

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Zody M.C.
Garber M.
Sharpe T.
Young S.K.
Rowen L.
O'Neill K.
Whittaker C.A.
Kamal M.
Chang J.L.
Cuomo C.A.
Dewar K.
FitzGerald M.G.
Kodira C.D.
Madan A.
Qin S.
Yang X.
Abbasi N.
Abouelleil A.
Arachchi H.M.
Baradarani L.
Birditt B.
Bloom S.
Bloom T.
Borowsky M.L.
Burke J.
Butler J.
Cook A.
DeArellano K.
DeCaprio D.
Dorris L.III.
Dors M.
Eichler E.E.
Engels R.
Fahey J.
Fleetwood P.
Friedman C.
Gearin G.
Hall J.L.
Hensley G.
Johnson E.
Jones C.
Kamat A.
Kaur A.
Locke D.P.
Madan A.
Munson G.
Jaffe D.B.
Lui A.
Macdonald P.
Mauceli E.
Naylor J.W.
Nesbitt R.
Nicol R.
O'Leary S.B.
Ratcliffe A.
Rounsley S.
She X.
Sneddon K.M.
Stewart S.
Sougnez C.
Stone S.M.
Topham K.
Vincent D.
Wang S.
Zimmer A.R.
Birren B.W.
Hood L.
Lander E.S.
Nusbaum C.

Analysis of the DNA sequence and duplication history of human chromosome 15.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).

Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3

EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED


Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions

Helical

Galectin

Galectin

ARS-UCD1.2.


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Aplacophora Solenogastres Pholidoskepia Dondersiidae Helluoherpia

BHLH

PAS

PAS

Disordered

Disordered

Disordered

Disordered

Disordered

Basic residues

Basic and acidic residues

Basic and acidic residues

Low complexity

Polar residues

HLH, helix-loop-helix DNA-binding domain


Disordered

Disordered

COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Hirudinea Hirudinida Hirudiniformes Hirudinidae Hirudo


Belongs to the protease inhibitor I15 (antistasin) family

Antistasin-like

F:serine-type endopeptidase inhibitor activity


Eukaryota Sar Alveolata Apicomplexa Aconoidasida Piroplasmida Theileriidae Theileria

Lu X.
Wang S.
Chen L.
Liu M.
Liu Y.
Zhu H.
Jiang B.
Du S.
Bayin C.
Liu D.
Zhang W.

Cloning and prokaryotic expression of Theileria equi rhoptry neck protein 5 gene.

Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the vasopressin/oxytocin family

Helical

Helical

P:detection of stimulus involved in sensory perception


Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Lipid metabolism; sphingolipid metabolism

Helical

Helical

Helical

TLC

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.


Mungall A.J.
Palmer S.A.
Sims S.K.
Edwards C.A.
Ashurst J.L.
Wilming L.
Jones M.C.
Horton R.
Hunt S.E.
Scott C.E.
Gilbert J.G.
Clamp M.E.
Bethel G.
Milne S.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Andrews T.D.
Ashwell R.I.
Babbage A.K.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beare D.M.
Beasley H.
Beasley O.
Bird C.P.
Blakey S.
Bray-Allen S.
Brook J.
Brown A.J.
Brown J.Y.
Burford D.C.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Clark S.Y.
Clark G.
Clee C.M.
Clegg S.
Cobley V.
Collier R.E.
Collins J.E.
Colman L.K.
Corby N.R.
Coville G.J.
Culley K.M.
Dhami P.
Davies J.
Dunn M.
Earthrowl M.E.
Ellington A.E.
Evans K.A.
Faulkner L.
Francis M.D.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Ghori M.J.
Gilby L.M.
Gillson C.J.
Glithero R.J.
Grafham D.V.
Grant M.
Gribble S.
Griffiths C.
Griffiths M.
Hall R.
Halls K.S.
Hammond S.
Harley J.L.
Hart E.A.
Heath P.D.
Heathcott R.
Holmes S.J.
Howden P.J.
Howe K.L.
Howell G.R.
Huckle E.
Humphray S.J.
Humphries M.D.
Hunt A.R.
Johnson C.M.
Joy A.A.
Kay M.
Keenan S.J.
Kimberley A.M.
King A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.R.
Lloyd D.M.
Loveland J.E.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Maslen G.L.
Matthews L.
McCann O.T.
McLaren S.J.
McLay K.
McMurray A.
Moore M.J.
Mullikin J.C.
Niblett D.
Nickerson T.
Novik K.L.
Oliver K.
Overton-Larty E.K.
Parker A.
Patel R.
Pearce A.V.
Peck A.I.
Phillimore B.
Phillips S.
Plumb R.W.
Porter K.M.
Ramsey Y.
Ranby S.A.
Rice C.M.
Ross M.T.
Searle S.M.
Sehra H.K.
Sheridan E.
Skuce C.D.
Smith S.
Smith M.
Spraggon L.
Squares S.L.
Steward C.A.
Sycamore N.
Tamlyn-Hall G.
Tester J.
Theaker A.J.
Thomas D.W.
Thorpe A.
Tracey A.
Tromans A.
Tubby B.
Wall M.
Wallis J.M.
West A.P.
White S.S.
Whitehead S.L.
Whittaker H.
Wild A.
Willey D.J.
Wilmer T.E.
Wood J.M.
Wray P.W.
Wyatt J.C.
Young L.
Younger R.M.
Bentley D.R.
Coulson A.
Durbin R.
Hubbard T.
Sulston J.E.
Dunham I.
Rogers J.
Beck S.

The DNA sequence and analysis of human chromosome 6.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Eupercaria Spariformes Sparidae Acanthopagrus

Regulatory effects of dietary lipid levels on growth performance, lipid metabolism, ERS and inflammatory response of juvenile black seabream Acanthopagrus schlegelii under low-salinity environment.


Eukaryota Metazoa Porifera Demospongiae Heteroscleromorpha Poecilosclerida Latrunculiidae Latrunculia

PAS

Disordered

Disordered

Low complexity

Low complexity

Low complexity

Polar residues

Pro residues

Polar residues

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding


Eukaryota Metazoa Echinodermata Pelmatozoa Crinoidea

BHLH

PAS

PAS

Disordered

Hypoxia-inducible factor 1 subunit alpha

Hypoxia-inducible factor 1-alpha isoform 1


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

VWFA

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.

VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
fabids
Fabales
Fabaceae
Papilionoideae
50 kb inversion clade
NPAAA clade
Hologalegina
IRL clade
Trifolieae
Medicago

Myb-like

Disordered

Disordered

Disordered

Polar residues

Polar residues

MYB_SANT-LIKE DNA-BINDING DOMAIN PROTEIN


Eukaryota Metazoa Cnidaria Scyphozoa Semaeostomeae Ulmaridae Aurelia

Tetraradial symmetry disturbance and recovery at feeding-dependent tentacle initiations in Aurelia aurita polyps.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Liliopsida Arecaceae Calamoideae Calameae Salaccinae Salacca

Cucumber peeling cupredoxin-like protein

Phytocyanin

Disordered


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Disordered

Acidic residues

Basic and acidic residues


May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides

axial binding residue


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical


Nusbaum C.
Zody M.C.
Borowsky M.L.
Kamal M.
Kodira C.D.
Taylor T.D.
Whittaker C.A.
Chang J.L.
Cuomo C.A.
Dewar K.
FitzGerald M.G.
Yang X.
Abouelleil A.
Allen N.R.
Anderson S.
Bloom T.
Bugalter B.
Butler J.
Cook A.
DeCaprio D.
Engels R.
Garber M.
Gnirke A.
Hafez N.
Hall J.L.
Norman C.H.
Itoh T.
Jaffe D.B.
Kuroki Y.
Lehoczky J.
Lui A.
Macdonald P.
Mauceli E.
Mikkelsen T.S.
Naylor J.W.
Nicol R.
Nguyen C.
Noguchi H.
O'Leary S.B.
O'Neill K.
Piqani B.
Smith C.L.
Talamas J.A.
Topham K.
Totoki Y.
Toyoda A.
Wain H.M.
Young S.K.
Zeng Q.
Zimmer A.R.
Fujiyama A.
Hattori M.
Birren B.W.
Sakaki Y.
Lander E.S.

DNA sequence and analysis of human chromosome 18.


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Araneae Araneomorphae Entelegynae Lycosoidea Lycosidae Pardosa

NPC intracellular cholesterol transporter 2-like protein

MD-2-related lipid-recognition


Helical

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Disordered

Disordered

Polar residues

Polar residues

Low complexity

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

P:positive regulation of transcription by RNA polymerase II


Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Eurotiomycetes Eurotiomycetidae Eurotiales Aspergillaceae Penicillium

Moroz O.V.
Blagova E.
Lebedev A.A.
Skov L.K.
Pache R.A.
Schnorr K.M.
Kiemer L.
Friis E.P.
Nymand-Grarup S.
Ming L.
Ye L.
Klausen M.
Cohn M.T.
Schmidt E.G.W.
Davies G.J.
Wilson K.S.

Module walking using an SH3-like cell-wall-binding domain leads to a new GH184 family of muramidases.

X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH ZN(2+)


Helical

Helical

Helical

Helical


Mediator of RNA polymerase II transcription subunit 15-like protein

ARC105/Med15 mediator subunit central

ARC105/Med15 mediator subunit C-terminal

MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

HMG box

HMG box

Disordered

Disordered

Disordered

Basic and acidic residues

Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.

F:DNA-binding transcription activator activity, RNA polymerase II-specific

P:negative regulation of transcription by RNA polymerase II


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Rhodopsin 7-helix transmembrane proteins

Family A G protein-coupled receptor-like


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

Disordered

Church D.M.
Goodstadt L.
Hillier L.W.
Zody M.C.
Goldstein S.
She X.
Bult C.J.
Agarwala R.
Cherry J.L.
DiCuccio M.
Hlavina W.
Kapustin Y.
Meric P.
Maglott D.
Birtle Z.
Marques A.C.
Graves T.
Zhou S.
Teague B.
Potamousis K.
Churas C.
Place M.
Herschleb J.
Runnheim R.
Forrest D.
Amos-Landgraf J.
Schwartz D.C.
Cheng Z.
Lindblad-Toh K.
Eichler E.E.
Ponting C.P.

Lineage-specific biology revealed by a finished genome assembly of the mouse.

Church D.M.
Schneider V.A.
Graves T.
Auger K.
Cunningham F.
Bouk N.
Chen H.C.
Agarwala R.
McLaren W.M.
Ritchie G.R.
Albracht D.
Kremitzki M.
Rock S.
Kotkiewicz H.
Kremitzki C.
Wollam A.
Trani L.
Fulton L.
Fulton R.
Matthews L.
Whitehead S.
Chow W.
Torrance J.
Dunn M.
Harden G.
Threadgold G.
Wood J.
Collins J.
Heath P.
Griffiths G.
Pelan S.
Grafham D.
Eichler E.E.
Weinstock G.
Mardis E.R.
Wilson R.K.
Howe K.
Flicek P.
Hubbard T.

Modernizing reference genome assemblies.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pentatomoidea Pentatomidae Asopinae Eocanthecona

Pheromone/general odorant binding protein domain


BHLH

Disordered

Low complexity

Polar residues

Basic residues

Kostyuchenko R.P.
Nikanorova D.D.
Amosov A.V.

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.

F:DNA-binding transcription factor activity

HLH, helix-loop-helix DNA-binding domain