Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical

Helical

Helical

Helical


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Belongs to the glycosyltransferase 6 family

Zhong J.
Gao Y.M.
Mo C.P.
Zhang Y.
Li L.B.
Wei S.T.
Li T.Y.

Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A

HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Disordered

Low complexity

Polar residues

FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Aculeata Apoidea Anthophila Apidae Xylocopa Koptortosoma

Cytotoxin that provokes cell lysis. Induces leak currents in cell membranes in the same way as melittin, suggesting a membrane disrupting mode of action. Also activates DRG neurons. DRG activation and cell lysis is potentiated by phospholipase A2 (PA2). In vivo, intraplantar injection in mice causes spontaneous pain behaviors and paw swelling, which are also potentiated by PA2 coinjection

Proline amide

Shi N.
Szanto T.G.
He J.
Schroeder C.I.
Walker A.A.
Deuis J.R.
Vetter I.
Panyi G.
King G.F.
Robinson S.D.

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana.

NUCLEOTIDE SEQUENCE [MRNA]
PROTEIN SEQUENCE OF 34-50
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION
AMIDATION AT PRO-50
SYNTHESIS OF 34-50
FUNCTION
BIOASSAY


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Aplacophora Solenogastres Cavibelonia Epimeniidae Epimenia

PAS

PAS

Disordered

Basic residues

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1


Eukaryota Amoebozoa Evosea Eumycetozoa Myxogastria Myxogastromycetidae Physariida Physaraceae Physarum

alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose

Belongs to the glycosyl hydrolase 65 family

FYVE-type

Minami Y.
Morita R.
Okano S.
Ishii K.
Furukawa A.
Teramoto C.

Analysis of trehalose synthesis pathway from Physarum polycephalum.

Glycoside hydrolase, family 65, N-terminal domain

Zinc/RING finger domain, C3HC4 (zinc finger)


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Helical

Ionotropic glutamate receptor C-terminal

Ionotropic glutamate receptor L-glutamate and glycine-binding

Crucial to convey clamshell closure to channel opening

Interaction with the cone snail toxin Con-ikot-ikot

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

F:transmitter-gated monoatomic ion channel activity

P:cell surface receptor signaling pathway

Glutamate receptor ionotropic, kainate 1

Glutamate receptor ionotropic, kainate 2


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Sabellida Siboglinidae Ridgeia

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data

Chitin-binding type-2

Ig-like

Perez M.
Aroh O.
Sun Y.
Lan Y.
Juniper S.K.
Young C.R.
Angers B.
Qian P.Y.

Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.

CARTILAGE INTERMEDIATE LAYER PROTEIN 1-LIKE ISOFORM X1

CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

PUM-HD

Pumilio

Pumilio

Pumilio

Pumilio

Pumilio

Pumilio

Pumilio

Pumilio

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Polar residues

Pro residues

Kostyuchenko R.P.
Nikanorova D.D.
Amosov A.V.

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.

P:post-transcriptional regulation of gene expression


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Megaloptera Corydalidae Corydalinae Protohermes

Helical

Helical

Helical

Helical

Yang J.
Wen X.
Zou J.
Huang X.
Wu T.
Huang X.

De novo transcriptome analysis of Protohermes xanthodes Navas (Megaloptera: Corydalidae) reveling the effects of sublethal chlorpyrifos on the expression of cholinergic neuronal genes.

F:extracellular ligand-gated monoatomic ion channel activity

F:transmembrane signaling receptor activity

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Eupercaria Sciaenidae Argyrosomus

Hemopexin

Hemopexin


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

P:positive regulation of transcription by RNA polymerase II


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Tityus

Cryptide Pep-16

Dias N.B.
de Souza B.M.
Cocchi F.K.
Chalkidis H.M.
Dorce V.A.C.
Palma M.S.

Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.

PROTEIN SEQUENCE
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.


Eukaryota Metazoa Chordata Tunicata Ascidiacea Phlebobranchia Cionidae Ciona

Helical

Helical

Helical

Helical

Helical

Long T.
Zhang Y.
Donnelly L.
Li H.
Pien Y.C.
Liu N.
Olson E.N.
Li X.

Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.

STRUCTURE BY ELECTRON MICROSCOPY (3.22 ANGSTROMS)

POST-GPI ATTACHMENT TO PROTEINS FACTOR 6


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Low complexity

Polar residues

Low complexity

Polar residues

Low complexity

Polar residues

Low complexity

Low complexity

Low complexity

Polar residues

Low complexity

Polar residues

Polar residues

Polar residues

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]


axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Echinodermata Eleutherozoa Echinozoa Holothuroidea Aspidochirotacea Aspidochirotida Stichopodidae Apostichopus

Guanylate-binding protein N-terminal

Guanylate-binding protein/Atlastin C-terminal

P-loop containing nucleotide triphosphate hydrolases

Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Bivalvia Autobranchia Pteriomorphia Pterioida Pterioidea Pteriidae Pinctada

Belongs to the tumor necrosis factor family

Helical

THD

Characterism and functional analysis of a novel tumor necrosis factor from pearl oyster Pinctada fucata martensii.

F:tumor necrosis factor receptor binding

TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN


Ligated ion channel binding I - glutamate

Helical

Helical

Helical

Helical

Helical

Helical

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Grapsoidea Varunidae Eriocheir

Integration of transcriptomics and proteomics analysis reveals the molecular mechanism of Eriocheir sinensis gills exposed to heat stress.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Disordered

International Human Genome Sequencing Consortium

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Humphray S.J.
Oliver K.
Hunt A.R.
Plumb R.W.
Loveland J.E.
Howe K.L.
Andrews T.D.
Searle S.
Hunt S.E.
Scott C.E.
Jones M.C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Ashwell R.I.
Babbage A.K.
Babbage S.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beasley H.
Beasley O.
Bird C.P.
Bray-Allen S.
Brown A.J.
Brown J.Y.
Burford D.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Chen Y.
Clarke G.
Clark S.Y.
Clee C.M.
Clegg S.
Collier R.E.
Corby N.
Crosier M.
Cummings A.T.
Davies J.
Dhami P.
Dunn M.
Dutta I.
Dyer L.W.
Earthrowl M.E.
Faulkner L.
Fleming C.J.
Frankish A.
Frankland J.A.
French L.
Fricker D.G.
Garner P.
Garnett J.
Ghori J.
Gilbert J.G.
Glison C.
Grafham D.V.
Gribble S.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Guy J.
Hall R.E.
Hammond S.
Harley J.L.
Harrison E.S.
Hart E.A.
Heath P.D.
Henderson C.D.
Hopkins B.L.
Howard P.J.
Howden P.J.
Huckle E.
Johnson C.
Johnson D.
Joy A.A.
Kay M.
Keenan S.
Kershaw J.K.
Kimberley A.M.
King A.
Knights A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.
Lloyd D.M.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
McLaren S.
McLay K.E.
McMurray A.
Milne S.
Nickerson T.
Nisbett J.
Nordsiek G.
Pearce A.V.
Peck A.I.
Porter K.M.
Pandian R.
Pelan S.
Phillimore B.
Povey S.
Ramsey Y.
Rand V.
Scharfe M.
Sehra H.K.
Shownkeen R.
Sims S.K.
Skuce C.D.
Smith M.
Steward C.A.
Swarbreck D.
Sycamore N.
Tester J.
Thorpe A.
Tracey A.
Tromans A.
Thomas D.W.
Wall M.
Wallis J.M.
West A.P.
Whitehead S.L.
Willey D.L.
Williams S.A.
Wilming L.
Wray P.W.
Young L.
Ashurst J.L.
Coulson A.
Blocker H.
Durbin R.
Sulston J.E.
Hubbard T.
Jackson M.J.
Bentley D.R.
Beck S.
Rogers J.
Dunham I.

DNA sequence and analysis of human chromosome 9.

Finishing the euchromatic sequence of the human genome.


Glycosyl transferase family 28 C-terminal


WD

Disordered

C:Cul4A-RING E3 ubiquitin ligase complex

P:proteasome-mediated ubiquitin-dependent protein catabolic process

YVTN repeat-like/Quinoprotein amine dehydrogenase


Eukaryota
Fungi
Dikarya
Ascomycota
Pezizomycotina
Eurotiomycetes
Eurotiomycetidae
Eurotiales
Aspergillaceae
Aspergillus
Aspergillus subgen. Circumdati

Arginine-containing cyclodipeptide synthase ateA

Arginine-containing cyclodipeptide synthase; part of the cluster that mediates the biosynthesis of a highly modified cyclo-arginine-glutamate dipeptide (cRE) (PubMed:36702957). Within the pathway, ateA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Glu diketopiperazine (cRW) from L-arginyl-tRNA(Arg) + L-glutamyl-tRNA(Glu) (PubMed:36702957). Additional enzymes from the cluster then further modify the cyclo-Arg-Glu diketopiperazine (cRW) scaffold (Probable)

L-glutamyl-tRNA(Glu) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-glutamyl) + tRNA(Glu) + tRNA(Arg) + 2 H(+)

The conserved DDXXE motif is essential for catalytic activity

Belongs to the arginine-containing cyclodipeptide synthase family

Disordered

Conserved DDXXE motif

Polar residues

Yee D.A.
Niwa K.
Perlatti B.
Chen M.
Li Y.
Tang Y.

Genome mining for unknown-unknown natural products.

NUCLEOTIDE SEQUENCE [MRNA]
FUNCTION
CATALYTIC ACTIVITY
PATHWAY


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

Identification of Cytochrome P450s in Maconellicoccus hirsutus.


Disordered

Martin J.
Han C.
Gordon L.A.
Terry A.
Prabhakar S.
She X.
Xie G.
Hellsten U.
Chan Y.M.
Altherr M.
Couronne O.
Aerts A.
Bajorek E.
Black S.
Blumer H.
Branscomb E.
Brown N.C.
Bruno W.J.
Buckingham J.M.
Callen D.F.
Campbell C.S.
Campbell M.L.
Campbell E.W.
Caoile C.
Challacombe J.F.
Chasteen L.A.
Chertkov O.
Chi H.C.
Christensen M.
Clark L.M.
Cohn J.D.
Denys M.
Detter J.C.
Dickson M.
Dimitrijevic-Bussod M.
Escobar J.
Fawcett J.J.
Flowers D.
Fotopulos D.
Glavina T.
Gomez M.
Gonzales E.
Goodstein D.
Goodwin L.A.
Grady D.L.
Grigoriev I.
Groza M.
Hammon N.
Hawkins T.
Haydu L.
Hildebrand C.E.
Huang W.
Israni S.
Jett J.
Jewett P.B.
Kadner K.
Kimball H.
Kobayashi A.
Krawczyk M.C.
Leyba T.
Longmire J.L.
Lopez F.
Lou Y.
Lowry S.
Ludeman T.
Manohar C.F.
Mark G.A.
McMurray K.L.
Meincke L.J.
Morgan J.
Moyzis R.K.
Mundt M.O.
Munk A.C.
Nandkeshwar R.D.
Pitluck S.
Pollard M.
Predki P.
Parson-Quintana B.
Ramirez L.
Rash S.
Retterer J.
Ricke D.O.
Robinson D.L.
Rodriguez A.
Salamov A.
Saunders E.H.
Scott D.
Shough T.
Stallings R.L.
Stalvey M.
Sutherland R.D.
Tapia R.
Tesmer J.G.
Thayer N.
Thompson L.S.
Tice H.
Torney D.C.
Tran-Gyamfi M.
Tsai M.
Ulanovsky L.E.
Ustaszewska A.
Vo N.
White P.S.
Williams A.L.
Wills P.L.
Wu J.R.
Wu K.
Yang J.
Dejong P.
Bruce D.
Doggett N.A.
Deaven L.
Schmutz J.
Grimwood J.
Richardson P.
Rokhsar D.S.
Eichler E.E.
Gilna P.
Lucas S.M.
Myers R.M.
Rubin E.M.
Pennacchio L.A.

The sequence and analysis of duplication-rich human chromosome 16.


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Belongs to the sulfotransferase 1 family

Sulfotransferase


Nanos-type


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Lacks conserved residue(s) required for the propagation of feature annotation

CUB

Peptidase S1

Disordered

Basic and acidic residues

Basic and acidic residues


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Helical

Helical

Helical

Helical

Helical

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).


Eukaryota Cryptophyceae Pyrenomonadales Chroomonadaceae Chroomonas

Helical

Photosystem II reaction center protein M, PsbM


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Staphyliniformia Silphidae Nicrophorinae Nicrophorus

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:37379839). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:37379839). Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor (PubMed:37379839)

pppGp(2'-5')A = 2',3'-cGAMP + diphosphate

Cyclic GMP-AMP synthase-like receptor

Cunningham C.B.
Li L.
Wiberg R.A.
Shelton J.M.
Mckinney E.C.
Parker D.J.
Meagher R.B.
Benowitz K.M.
Roy-Zokan E.M.
Ritchie M.G.
Brown S.J.
Schmitz R.B.
Moore A.J.

The Nicrophorus vespilloides genome and methylome, a beetle with complex social behavior.

Li Y.
Slavik K.M.
Toyoda H.C.
Morehouse B.R.
de Oliveira Mann C.C.
Elek A.
Levy S.
Wang Z.
Mears K.S.
Liu J.
Kashin D.
Guo X.
Mass T.
Sebe-Pedros A.
Schwede F.
Kranzusch P.J.

cGLRs are a diverse family of pattern recognition receptors in innate immunity.

F:2',3'-cyclic GMP-AMP synthase activity

CELL FATE DETERMINING PROTEIN MAB21-RELATED

CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED


Disordered

Disordered

Disordered

Polar residues

Acidic residues

axial binding residue

Haem peroxidase domain superfamily, animal type


Helical

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pentatomoidea Pentatomidae Asopinae Eocanthecona

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Helical

Helical

G-protein coupled receptors family 1 profile

Disordered

Basic and acidic residues

Polar residues

F:G protein-coupled peptide receptor activity

Rhodopsin 7-helix transmembrane proteins

G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED

G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN

Family A G protein-coupled receptor-like


Helical

Helical

Helical


Helical

Helical

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Interacts with the splicing factor SRSF3 and increases its binding to specific exons within pre-mRNA, thereby regulating exon-inclusion during alternative splicing (PubMed:32440474). Does not directly bind pre-mRNA and could regulate a wider range of splicing factors through a similar mechanism (PubMed:32440474)

Interacts with SRSF3; increases SRSF3 binding to specific exons

Splicing regulatory small protein

Disordered

Mediates interaction with SRSF3

Disordered

Basic residues

Basic and acidic residues

Polar residues

Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.-M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.-P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

Meng N.
Chen M.
Chen D.
Chen X.H.
Wang J.Z.
Zhu S.
He Y.T.
Zhang X.L.
Lu R.X.
Yan G.R.

Small protein hidden in lncRNA LOC90024 promotes 'cancerous' RNA splicing and tumorigenesis.

IDENTIFICATION BY MASS SPECTROMETRY
FUNCTION
INTERACTION WITH SRSF3
REGION


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Thysanoptera Terebrantia Thripoidea Thripidae Thrips

Vitellinogen open beta-sheet

Lipovitellin-phosvitin complex, chain A, domain 4

Lipovitellin-phosvitin complex, beta-sheet shell regions


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Caelifera Acrididea Acridomorpha Acridoidea Acrididae Oedipodinae Locusta

Ubiquitin-like

Disordered

Disordered

Disordered

Polar residues

Gly residues

Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.

Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Helical

Helical

Distal membrane-arm assembly complex protein 1-like

Strausberg R.L.
Feingold E.A.
Grouse L.H.
Derge J.G.
Klausner R.D.
Collins F.S.
Wagner L.
Shenmen C.M.
Schuler G.D.
Altschul S.F.
Zeeberg B.
Buetow K.H.
Schaefer C.F.
Bhat N.K.
Hopkins R.F.
Jordan H.
Moore T.
Max S.I.
Wang J.
Hsieh F.
Diatchenko L.
Marusina K.
Farmer A.A.
Rubin G.M.
Hong L.
Stapleton M.
Soares M.B.
Bonaldo M.F.
Casavant T.L.
Scheetz T.E.
Brownstein M.J.
Usdin T.B.
Toshiyuki S.
Carninci P.
Prange C.
Raha S.S.
Loquellano N.A.
Peters G.J.
Abramson R.D.
Mullahy S.J.
Bosak S.A.
McEwan P.J.
McKernan K.J.
Malek J.A.
Gunaratne P.H.
Richards S.
Worley K.C.
Hale S.
Garcia A.M.
Gay L.J.
Hulyk S.W.
Villalon D.K.
Muzny D.M.
Sodergren E.J.
Lu X.
Gibbs R.A.
Fahey J.
Helton E.
Ketteman M.
Madan A.
Rodrigues S.
Sanchez A.
Whiting M.
Madan A.
Young A.C.
Shevchenko Y.
Bouffard G.G.
Blakesley R.W.
Touchman J.W.
Green E.D.
Dickson M.C.
Rodriguez A.C.
Grimwood J.
Schmutz J.
Myers R.M.
Butterfield Y.S.
Krzywinski M.I.
Skalska U.
Smailus D.E.
Schnerch A.
Schein J.E.
Jones S.J.
Marra M.A.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

Gaudet P.
Livstone M.S.
Lewis S.E.
Thomas P.D.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.


Eukaryota Metazoa Porifera Calcarea Calcinea Clathrinida Leucettidae Leucetta

BZIP

Gene networks governing the response of a calcareous sponge to future ocean conditions reveal lineage-specific XBP1 regulation of the unfolded protein response.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding


Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED


Epithelial sodium channel/degenerin-like protein

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family

Helical

Helical

Disordered

Polar residues

Basic residues

Basic residues

Polar residues


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pyrrhocoroidea Pyrrhocoridae Pyrrhocoris

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)

receptor protein-tyrosine kinase

Helical

Protein kinase

Disordered

Basic and acidic residues

F:transmembrane receptor protein tyrosine kinase activity

P:cell surface receptor protein tyrosine kinase signaling pathway

P:positive regulation of intracellular signal transduction

Proto-oncogene tyrosine-protein kinase receptor Ret


Bacteria Pseudomonadati Pseudomonadota Gammaproteobacteria Oceanospirillales Hahellaceae Hahella

Hu W.
Yang B.
Xiao Q.
Wang Y.
Shuai Y.
Zhao G.
Zhang L.
Deng Z.
He X.
Liu G.

Characterization of a promiscuous DNA sulfur binding domain and application in site-directed RNA base editing.

X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH MG(2+)


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Megalopygidae Megalopyge

Walker A.A.
Robinson S.D.
Merritt D.J.
Cardoso F.C.
Goudarzi M.H.
Mercedes R.S.
Eagles D.A.
Cooper P.
Zdenek C.N.
Fry B.G.
Hall D.W.
Vetter I.
King G.F.

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).

NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
SYNTHESIS OF 30-55
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Gobiaria Gobiiformes Gobioidei Gobiidae Gobiinae Knipowitschia

Secreted, extracellular space, extracellular matrix

Ig-like

CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides

Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Peptidase S1


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Transposase Tnp1/En/Spm-like domain-containing protein

Disordered

Disordered

Basic residues

Basic and acidic residues

Acidic residues

Basic residues


The zebrafish reference genome sequence and its relationship to the human genome.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Disordered

Initial sequencing and analysis of the human genome.

DNA sequence and analysis of human chromosome 9.

Finishing the euchromatic sequence of the human genome.


Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Helical

Helical

F:ligand-gated monoatomic ion channel activity


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

MD-2-related lipid-recognition domain-containing protein

MD-2-related lipid-recognition


Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).

F:cysteine-type endopeptidase inhibitor activity


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Microhyloidea Microhylidae Dyscophinae Dyscophus

IgGFc-binding protein N-terminal

IgGFc-binding protein N-terminal

IgGFc-binding protein N-terminal

Disordered

Low complexity

Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.


Eukaryota
Fungi
Dikarya
Ascomycota
Pezizomycotina
Sordariomycetes
Hypocreomycetidae
Glomerellales
Glomerellaceae
Colletotrichum
Colletotrichum acutatum species complex

Key lime anthracnose pathogenicity protein

Zambounis A.
Angeli C.
Tsalgatidou P.
Delis C.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Tineoidea Gracillariidae Conopomorpha


Fibronectin type-III

Fibronectin type-III

Fibronectin type-III


Helical

Helical

axial binding residue

Identification of Cytochrome P450s in Maconellicoccus hirsutus.


Eukaryota Rhodophyta Florideophyceae Rhodymeniophycidae Gigartinales Solieriaceae Eucheuma

Peptidase C83

Disordered

Functional characterisation of phytochelatin synthase from Eucheuma denticulatum (Rhodophyta).

Phytochelatin synthase, N-terminal domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Helical

Helical

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Lacks conserved residue(s) required for the propagation of feature annotation

Metalloendopeptidase

Peptidase M12A

DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING

Metalloproteases ('zincins'), catalytic domain


Disordered

F:cellulose synthase (UDP-forming) activity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Maruca

an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

axial binding residue

C18 oxylipin, EpOME, mediates the immune resolution at late infection stage in the legume pod borer, Maruca vitrata.


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Araneae Araneomorphae Entelegynae Lycosoidea Ctenidae Cupiennius

acetylcholine + H2O = choline + acetate + H(+)

Belongs to the type-B carboxylesterase/lipase family

Carboxylic ester hydrolase

Carboxylesterase type B

Acyl-ester intermediate

Charge relay system

Charge relay system

Liu H.
Jang J.
French A.S.
Torkkeli P.H.

Expression and Characterization of Seven Acetylcholine esterases in the Spider Cupiennius salei.


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding


Adaptor related protein complex 4 subunit beta 1

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.


Peptidase S1


Helical


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
Liliopsida
Poales
Poaceae
BOP clade
Pooideae
Triticodae
Triticeae
Triticinae
Aegilops

non-specific serine/threonine protein kinase

L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)

L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)

Belongs to the protein kinase superfamily

Protein kinase

Disordered

Polar residues

MLKL-K, a mixed lineage kinase-like domain-containing kinase gene, originated from Aegilops longissima confers resistance to wheat powdery mildew.

F:protein serine/threonine kinase activity

P:cell surface receptor signaling pathway

C2 CALCIUM/LIPID-BINDING PLANT PHOSPHORIBOSYLTRANSFERASE FAMILY PROTEIN

PROTEIN KINASE DOMAIN-CONTAINING PROTEIN


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Single

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the UDP-glycosyltransferase family

Helical

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).


CUB

Disordered

Gly residues

Low complexity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Odorant binding protein/PBP-general odorant binding protein

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

VWFA

VWFA

VWFA

Disordered

Low complexity

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Craniiformea Craniata Craniida Cranioidea Craniidae Novocrania

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family

Helical

Disordered

Basic and acidic residues

Borve A.
Marti-Solans J.
Lynagh T.
Hejnol A.

Diarylamidine Activation of a Brachiopod DEG/ENaC/ASIC Channel.

AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Importin N-terminal

Mikhailov K.
Kravchuk O.
Lyupina Y.
Adameyko K.

F:nuclear export signal receptor activity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Disordered

Basic residues

Initial sequencing and analysis of the human genome.

Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.


Disordered

axial binding residue

Haem peroxidase domain superfamily, animal type


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Hirudinea Hirudinida Hirudiniformes Hirudinidae Hirudo

F5/8 type C domain-containing protein


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Polypodiopsida Polypodiidae Polypodiales Polypodiineae Polypodiaceae Microsoroideae Leptochilus

Wei J.Z.
Lum A.
Schepers E.
Liu L.
Weston R.T.
McGinness B.S.
Heckert M.J.
Xie W.
Kassa A.
Bruck D.
Rauscher G.
Kapka-Kitzman D.
Mathis J.P.
Zhao J.Z.
Sethi A.
Barry J.
Lu A.L.
Brugliera F.
Lee E.L.
van derWeerden N.L.
Eswar N.
Maher M.J.
Anderson M.A.

Novel insecticidal proteins from ferns resemble insecticidal proteins from <i>Bacillus thuringiensis</i>.

X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS)
DISULFIDE BONDS

Pesticidal crystal protein, N-terminal domain

delta-Endotoxin (insectocide), N-terminal domain


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Rhynchonelliformea Rhynchonellata Terebratellidina Laqueoidea Laqueidae Laqueus

PAS

Disordered

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1


Disordered

Low complexity

Basic residues


Eukaryota Metazoa Cnidaria Scyphozoa Semaeostomeae Ulmaridae Aurelia

TGF-beta propeptide

Disordered

Basic and acidic residues

Basic residues

Tetraradial symmetry disturbance and recovery at feeding-dependent tentacle initiations in Aurelia aurita polyps.


Helical


VWFA

Disordered

Pro residues


Helical

Helical

axial binding residue


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Caelifera Acrididea Acridomorpha Acridoidea Acrididae Oedipodinae Locusta

ARID

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Basic residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Polar residues

Low complexity

Basic residues

Low complexity

Acidic residues

Polar residues

Pro residues

Acidic residues

Polar residues

Polar residues

Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.

F:transcription cis-regulatory region binding

P:regulation of transcription by RNA polymerase II

AT-rich interactive domain-containing protein 4B


Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

F:transmitter-gated monoatomic ion channel activity

P:cell surface receptor signaling pathway

Glutamate receptor ionotropic, kainate 2

Putative glutamate receptor ionotropic kainate 1


Deleted in malignant brain tumors 1 protein-like protein 3

Lacks conserved residue(s) required for the propagation of feature annotation

SRCR

SRCR

Fibronectin type-III

Scavenger receptor cysteine-rich protein type 12

Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D


After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily

Helical

Helical

Helical

Helical

F:acetylcholine-gated monoatomic cation-selective channel activity

F:transmembrane signaling receptor activity

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3

EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Curculionidae Curculioninae Anthonomini Anthonomus

Segura Leon O.L.
Lechuga-Paredes P.
Cibrian Tovar J.
Torres Huerta B.

Lechuga-Paredes P.
Segura-Leon O.L.
Cibrian-Tovar J.
Torres-Huerta B.
Velazquez-Gonzalez J.C.
Cruz-Jaramillo J.L.

Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Terebellida Terebelliformia Alvinellidae Alvinella

RecA family profile 1

Longo M.A.
Roy S.
Chen Y.
Tomaszowski K.H.
Arvai A.S.
Pepper J.T.
Boisvert R.A.
Kunnimalaiyaan S.
Keshvani C.
Schild D.
Bacolla A.
Williams G.J.
Tainer J.A.
Schlacher K.

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.

X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ADP

F:ATP-dependent DNA damage sensor activity

P:double-strand break repair via synthesis-dependent strand annealing

P:resolution of mitotic recombination intermediates

P:telomere maintenance via recombination

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


IF rod

LTD

Disordered

Intermediate filament protein, coiled coil region


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Belongs to the krueppel C2H2-type zinc-finger protein family

Disordered

Disordered

Basic residues

Basic and acidic residues

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.

F:DNA-binding transcription repressor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

zinc finger and SCAN domain-containing protein 29

GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED


Disordered

Acidic residues

Finishing the euchromatic sequence of the human genome.

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Eukaryota Sar Stramenopiles Bigyra Labyrinthulomycetes Thraustochytrida Thraustochytriidae Schizochytrium

an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA

Helical

Helical

Helical

Helical

Helical

Helical

Metabolism balance regulation for squalene production by disturbing triglycerides (TAG) synthesis in Schizochytrium sp.

P:fatty acid elongation, monounsaturated fatty acid

P:fatty acid elongation, polyunsaturated fatty acid

P:fatty acid elongation, saturated fatty acid

P:very long-chain fatty acid biosynthetic process


Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Lacks conserved residue(s) required for the propagation of feature annotation

Helical

Helical

Helical

Helical

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Peptidase S1

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).

Atrial natriuretic peptide-converting enzyme


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the G-protein coupled receptor 3 family

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 3 profile

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

G-PROTEIN COUPLED RECEPTOR CG31760-RELATED


Belongs to the plakin or cytolinker family

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Mungall A.J.
Palmer S.A.
Sims S.K.
Edwards C.A.
Ashurst J.L.
Wilming L.
Jones M.C.
Horton R.
Hunt S.E.
Scott C.E.
Gilbert J.G.
Clamp M.E.
Bethel G.
Milne S.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Andrews T.D.
Ashwell R.I.
Babbage A.K.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beare D.M.
Beasley H.
Beasley O.
Bird C.P.
Blakey S.
Bray-Allen S.
Brook J.
Brown A.J.
Brown J.Y.
Burford D.C.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Clark S.Y.
Clark G.
Clee C.M.
Clegg S.
Cobley V.
Collier R.E.
Collins J.E.
Colman L.K.
Corby N.R.
Coville G.J.
Culley K.M.
Dhami P.
Davies J.
Dunn M.
Earthrowl M.E.
Ellington A.E.
Evans K.A.
Faulkner L.
Francis M.D.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Ghori M.J.
Gilby L.M.
Gillson C.J.
Glithero R.J.
Grafham D.V.
Grant M.
Gribble S.
Griffiths C.
Griffiths M.
Hall R.
Halls K.S.
Hammond S.
Harley J.L.
Hart E.A.
Heath P.D.
Heathcott R.
Holmes S.J.
Howden P.J.
Howe K.L.
Howell G.R.
Huckle E.
Humphray S.J.
Humphries M.D.
Hunt A.R.
Johnson C.M.
Joy A.A.
Kay M.
Keenan S.J.
Kimberley A.M.
King A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.R.
Lloyd D.M.
Loveland J.E.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Maslen G.L.
Matthews L.
McCann O.T.
McLaren S.J.
McLay K.
McMurray A.
Moore M.J.
Mullikin J.C.
Niblett D.
Nickerson T.
Novik K.L.
Oliver K.
Overton-Larty E.K.
Parker A.
Patel R.
Pearce A.V.
Peck A.I.
Phillimore B.
Phillips S.
Plumb R.W.
Porter K.M.
Ramsey Y.
Ranby S.A.
Rice C.M.
Ross M.T.
Searle S.M.
Sehra H.K.
Sheridan E.
Skuce C.D.
Smith S.
Smith M.
Spraggon L.
Squares S.L.
Steward C.A.
Sycamore N.
Tamlyn-Hall G.
Tester J.
Theaker A.J.
Thomas D.W.
Thorpe A.
Tracey A.
Tromans A.
Tubby B.
Wall M.
Wallis J.M.
West A.P.
White S.S.
Whitehead S.L.
Whittaker H.
Wild A.
Willey D.J.
Wilmer T.E.
Wood J.M.
Wray P.W.
Wyatt J.C.
Young L.
Younger R.M.
Bentley D.R.
Coulson A.
Durbin R.
Hubbard T.
Sulston J.E.
Dunham I.
Rogers J.
Beck S.

The DNA sequence and analysis of human chromosome 6.

P:intermediate filament cytoskeleton organization


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Apocynaceae Asclepiadoideae Marsdenieae Gymnema

RIN4 pathogenic type III effector avirulence factor Avr cleavage site

Disordered

Disordered

Polar residues

Transcriptomic revealing of plant pathogen interaction in Gymnema sylvestre.

RPM1-INTERACTING PROTEIN 4 (RIN4) FAMILY PROTEIN


AB hydrolase-1


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pyrrhocoroidea Pyrrhocoridae Pyrrhocoris


Pheromone/general odorant binding protein domain


Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family

Helical

Helical

Helical

Disordered

Disordered

Polar residues

F:ligand-gated monoatomic ion channel activity

glutamate receptor ionotropic, NMDA 1 isoform X1

Putative glutamate receptor ionotropic NMDA 2B


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Aculeata Formicoidea Formicidae Myrmicinae Pogonomyrmex

Toxin that causes a rapid and irreversible paralysis when intrathoracically injected into insects (blowflies). Does not cause spontaneous nocifensive behaviors by intraplantar injection in mice. Exhibits hemolytic and cytotoxic activities on HEK293 cells

PD(50) [1 hour] is 9.9 nmol/g when intrathoracically injected into insects (blowfly L.caesar)

Belongs to the formicidae venom clade 3 family

Valine amide

Robinson S.D.
Deuis J.R.
Niu P.
Touchard A.
Mueller A.
Schendel V.
Brinkwirth N.
King G.F.
Vetter I.
Schmidt J.O.

Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants.

NUCLEOTIDE SEQUENCE [MRNA]
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION
SYNTHESIS OF 38-66
BIOASSAY
TOXIC DOSE
AMIDATION AT VAL-66


Helical


Gamma-aminobutyric acid receptor subunit beta

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily

Helical

Helical

Helical

Helical

Disordered

Low complexity

F:extracellular ligand-gated monoatomic ion channel activity

F:ligand-gated monoatomic anion channel activity

F:transmembrane signaling receptor activity

Gamma-aminobutyric acid receptor isoform 3b

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Fibrinogen C-terminal


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Tineoidea Gracillariidae Conopomorpha

Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Lacks conserved residue(s) required for the propagation of feature annotation

Helical

Helical

Helical

Helical

Helical

Helical


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Pinopsida
Pinidae
Conifers I
Pinales
Pinaceae
Pinus
Pinus subgen. Pinus

Belongs to the helicase family. Dicer subfamily

Helicase C-terminal

Dicer dsRNA-binding fold

PAZ

RNase III

RNase III

DRBM

DRBM

Disordered

Polar residues

Identification of RNAi-Related Genes and Transcriptome Assembly of Loblolly Pine (Pinus taeda, L.) Seedlings Exposed to Insect-Specific dsRNA.

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

axial binding residue

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Spiralia Lophotrochozoa Platyhelminthes Rhabditophora Seriata Tricladida Continenticola Geoplanoidea Dugesiidae Dugesia

Fibronectin type-II

Identification of a GLIPR1-like gene in planarian Dugesia japonica.


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
fabids
Fabales
Fabaceae
Papilionoideae
50 kb inversion clade
NPAAA clade
indigoferoid/millettioid clade
Millettieae
Pongamia

Mature leaf cDNA fragments from Pongamia pinnata.


Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Sordariomycetes Xylariomycetidae Amphisphaeriales Apiosporaceae Apiospora

Arginine-containing cyclodipeptide synthase amaA

Arginine-containing cyclodipeptide synthase; part of the cluster that mediates the biosynthesis of a highly modified cyclo-arginine-proline dipeptide (cRP) (PubMed:36702957). Within the pathway, amaA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Pro diketopiperazine (cRW) from L-arginyl-tRNA(Arg) + L-prolyl-tRNA(Pro) (PubMed:36702957). Additional enzymes from the cluster then further modify the cyclo-Arg-Pro diketopiperazine (cRW) scaffold (Probable)

L-prolyl-tRNA(Pro) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-prolyl) + tRNA(Pro) + tRNA(Arg) + 2 H(+)

The conserved DDXXE motif is essential for catalytic activity

Belongs to the arginine-containing cyclodipeptide synthase family

Conserved DDXXE motif

Yee D.A.
Niwa K.
Perlatti B.
Chen M.
Li Y.
Tang Y.

Genome mining for unknown-unknown natural products.


Bacteria Bacillati Cyanobacteriota Cyanophyceae Gloeobacterales Anthocerotibacteraceae Anthocerotibacter

Belongs to the phycobilisome linker protein family

PBS-linker

PBS-linker

Jiang H.W.
Wu H.Y.
Wang C.H.
Yang C.H.
Ko J.T.
Ho H.C.
Tsai M.D.
Bryant D.A.
Li F.W.
Ho M.C.
Ho M.Y.

A structure of the relict phycobilisome from a thylakoid-free cyanobacterium.

STRUCTURE BY ELECTRON MICROSCOPY (2.74 ANGSTROMS)

C:plasma membrane-derived thylakoid membrane

PHYCOBILISOME 32.1 KDA LINKER POLYPEPTIDE, PHYCOCYANIN-ASSOCIATED, ROD 2-RELATED


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

VWFA

VWFA

VWFA

VWFA

VWFA

VWFA

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Helical

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Peracarida Isopoda Oniscidea Crinocheta Paraplatyarthridae Paraplatyarthrus

cellulose 1,4-beta-cellobiosidase (non-reducing end)

Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.

Belongs to the glycosyl hydrolase 7 (cellulase C) family

Javidkar M.
Cooper S.J.B.
Shokri Bousjein N.
Humphreys W.F.
King R.A.
Austin A.D.

Evolution of endoglucanase genes in subterranean and surface isopod crustaceans from Central Western Australia.

F:hydrolase activity, hydrolyzing O-glycosyl compounds


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Curculionidae Scolytinae Ips

Helical

Helical

Helical

Helical

Helical

Helical

Biswas T.
Sims C.
Yuvaraj J.K.
Roberts R.E.
Lofstedt C.
Andersson M.N.

Functional characterization supports multiple evolutionary origins of pheromone receptors bark beetles.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Cervidae Cervinae Cervus


Eukaryota Metazoa Cnidaria Scyphozoa Semaeostomeae Ulmaridae Aurelia

Helical

Protein kinase

Proton acceptor

Tetraradial symmetry disturbance and recovery at feeding-dependent tentacle initiations in Aurelia aurita polyps.

F:transmembrane receptor protein tyrosine kinase activity

P:cell surface receptor protein tyrosine kinase signaling pathway

FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Curculionidae Curculioninae Anthonomini Anthonomus

Disordered

Segura Leon O.L.
Lechuga-Paredes P.
Cibrian Tovar J.
Torres Huerta B.

Lechuga-Paredes P.
Segura-Leon O.L.
Cibrian-Tovar J.
Torres-Huerta B.
Velazquez-Gonzalez J.C.
Cruz-Jaramillo J.L.

Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Megaloptera Corydalidae Corydalinae Protohermes

Helical

Helical

Helical

Helical

Farnesoic acid O-methyl transferase

Yang J.
Wen X.
Zou J.
Huang X.
Wu T.
Huang X.

De novo transcriptome analysis of Protohermes xanthodes Navas (Megaloptera: Corydalidae) reveling the effects of sublethal chlorpyrifos on the expression of cholinergic neuronal genes.

F:extracellular ligand-gated monoatomic ion channel activity

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Peracarida Isopoda Oniscidea Crinocheta Porcellionidae Porcellionides

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Belongs to the glycosyl hydrolase 9 (cellulase E) family

cellulase

Glycoside hydrolase family 9


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Cephalopoda Coleoidea Octopodiformes Octopoda Incirrata Octopodidae Callistoctopus

Belongs to the group II decarboxylase family

Disordered

Basic and acidic residues

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

Rhodopsin 7-helix transmembrane proteins

Family A G protein-coupled receptor-like


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Cystatin

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).

F:cysteine-type endopeptidase inhibitor activity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Bacteria Pseudomonadati Pseudomonadota Gammaproteobacteria Enterobacterales Enterobacteriaceae Citrobacter

A small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (usually speF and potE) by transcriptional and translational attenuation

Binds ornithine in stalled 70S ribosomes, blocking the upper two-thirds of the exit tunnel. Contacts 23S rRNA and ribosomal proteins L4 and L22

Induced by ornithine, repressed by putrescine. Part of the speFL-speF-potE operon

Belongs to the speF operon leader peptide family

Ornithine recognition loop

P:regulation of translational elongation

P:transcriptional attenuation by ribosome


Metabotropic glutamate receptor-like protein

Helical

Helical

Helical

Helical

Helical

Helical

Helical


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Fabales Fabaceae Detarioideae Saraceae Saraca

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily

Transcriptome analysis of Saraca asoca.

F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Auchenorrhyncha Membracoidea Cicadellidae Typhlocybinae Empoascini Empoasca

Disordered

Disordered

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity


Helical

Helical

Helical


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Rhynchonelliformea Rhynchonellata Terebratellidina Laqueoidea Laqueidae Terebratalia

Ligand for members of the frizzled family of seven transmembrane receptors

Secreted, extracellular space, extracellular matrix

Helical

Vellutini B.C.
Martin-Duran J.M.
Borve A.
Hejnol A.

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.


Cystatin


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

K-box

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Belongs to the AB hydrolase superfamily. AB hydrolase 2 family

Phospholipase/carboxylesterase/thioesterase

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.


axial binding residue

Identification of Cytochrome P450s in Maconellicoccus hirsutus.


Helical

IONOTROPIC RECEPTOR 31A, ISOFORM C-RELATED


Disordered

Polar residues

Low complexity

Polar residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues


Helical

Helical


Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Rhodopsin 7-helix transmembrane proteins

Family A G protein-coupled receptor-like


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Disordered

Disordered

Basic and acidic residues

Basic and acidic residues


Galectin

Galectin


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Belongs to the calycin superfamily. Triabin family

P:symbiont-mediated perturbation of host defenses


Belongs to the biopterin-dependent aromatic amino acid hydroxylase family

Biopterin-dependent aromatic amino acid hydroxylase family profile

Aromatic aminoacid monoxygenases, catalytic and oligomerization domains


Helical

SEA

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.


Bacteria Bacillati Cyanobacteriota Cyanophyceae Gloeobacterales Anthocerotibacteraceae Anthocerotibacter

CpcD-like

A structure of the relict phycobilisome from a thylakoid-free cyanobacterium.

C:plasma membrane-derived thylakoid membrane


MADS-box

HMA

HMA

Disordered

Basic and acidic residues

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

F:cis-regulatory region sequence-specific DNA binding

F:DNA-binding transcription factor activity, RNA polymerase II-specific

P:positive regulation of transcription by RNA polymerase II

HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 4

HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 7


May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides

Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


Disordered

Disordered

Disordered

Basic and acidic residues

Basic residues

Basic and acidic residues

Polar residues

Low complexity

Polar residues

Low complexity

NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.

Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3


Glycoside hydrolase/deacetylase, beta/alpha-barrel-like protein

Helical

NodB homology

Disordered

Disordered

Low complexity

Low complexity

Basic residues

Low complexity

F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds


Tubulin/FtsZ 2-layer sandwich

Augustine N.
Selvapandian U.
Muthugoundar M.

Evaluation of reference genes for expression studies in the broad mite, Polyphagotarsonemus latus (Acari: Tarsonemidae).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
malvids
Myrtales
Myrtaceae
Myrtoideae
Myrteae
Pimenta group
Psidium

Terpene synthase N-terminal

Terpene synthase metal-binding

Canal D.
dos Santos P.H.D.
Carpinetti-Oliveira P.A.
Silva M.A.
Fernandes M.
Brustolini O.J.B.
Ferreira A.
Ferreira M.F.S.

Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.


Bacteria Pseudomonadati Pseudomonadota Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia

Controls the expression of small non-coding RNA GcvB, which represses the expression of many amino acid transporter proteins and uptake of aminoglycoside antibiotics in cells (PubMed:35081614). Might be a transcriptional activator (Probable) (PubMed:35081614). An RNA (xtr) with a tRNA-like fold possibly derived from tRNA-Arg(UCG) is encoded entirely within the protein; xtr does not have the sequence corresponding to tRNA anticodon or variable arms (PubMed:35081614). 10 synonymous codon changes in the xtr region of xtpA have the same phenotype as a deletion mutation, suggesting the mRNA secondary structure is important for function (PubMed:35081614)

Increased susceptibility to sub-lethal concentrations of aminoglycoside antibiotics neomycin, kanamycin, streptomycin, spectinomycin and kasugamycin, but not non-aminoglycosides tetracycline, chloramphenicol or erythromycin. 10-fold increased transcription of gvcB

Putative transcriptional regulator XtpA

Increased sensitivity to aminoglycoside neomycin.

Blattner F.R.
Plunkett G. III
Bloch C.A.
Perna N.T.
Burland V.
Riley M.
Collado-Vides J.
Glasner J.D.
Rode C.K.
Mayhew G.F.
Gregor J.
Davis N.W.
Kirkpatrick H.A.
Goeden M.A.
Rose D.J.
Mau B.
Shao Y.

The complete genome sequence of Escherichia coli K-12.

Muto A.
Goto S.
Kurita D.
Ushida C.
Soma A.
Himeno H.

A leaderless mRNA including tRNA-like sequence encodes a small peptide that regulates the expression of GcvB small RNA in Escherichia coli.

IDENTIFICATION
FUNCTION
DISRUPTION PHENOTYPE
MUTAGENESIS OF 50-PRO--PHE-60
MUTAGENESIS OF 4-TRP--PHE-60


Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013)

Viruses
Riboviria
Orthornavirae
Kitrinoviricota
Flasuviricetes
Amarillovirales
Flaviviridae
Orthoflavivirus
Orthoflavivirus zikaense

Plays a role in the reorganization of host microtubules and intermediate filaments to form a cytoskeletal cage that surrounds the viral factories, protecting the site of viral replication. May play a role in viral infection of human cortical neurons

Product of an upstream open reading frame of the genome polyprotein gene

The initiator methionine is coded by an unusual start codon CTG

Belongs to the Zika virus American lineage encoding for a two uORF

uORF1 protein

Complete loss of granular structures in the cytoplasm.

Baronti C.
Piorkowski G.
Charrel R.N.
Boubis L.
Leparc-Goffart I.
de Lamballerie X.

Complete coding sequence of zika virus from a French polynesia outbreak in 2013.

Lefevre C.
Cook G.M.
Dinan A.M.
Torii S.
Stewart H.
Gibbons G.
Nicholson A.S.
Echavarria-Consuegra L.
Meredith L.W.
Lulla V.
McGovern N.
Kenyon J.C.
Goodfellow I.
Deane J.E.
Graham S.C.
Lakatos A.
Lambrechts L.
Brierley I.
Irigoyen N.

Zika viruses encode 5' upstream open reading frames affecting infection of human brain cells.

ALTERNATIVE INITIATION (ISOFORM UROF1 AND UORF2)


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Disordered

Polar residues

Zody M.C.
Garber M.
Sharpe T.
Young S.K.
Rowen L.
O'Neill K.
Whittaker C.A.
Kamal M.
Chang J.L.
Cuomo C.A.
Dewar K.
FitzGerald M.G.
Kodira C.D.
Madan A.
Qin S.
Yang X.
Abbasi N.
Abouelleil A.
Arachchi H.M.
Baradarani L.
Birditt B.
Bloom S.
Bloom T.
Borowsky M.L.
Burke J.
Butler J.
Cook A.
DeArellano K.
DeCaprio D.
Dorris L.III.
Dors M.
Eichler E.E.
Engels R.
Fahey J.
Fleetwood P.
Friedman C.
Gearin G.
Hall J.L.
Hensley G.
Johnson E.
Jones C.
Kamat A.
Kaur A.
Locke D.P.
Madan A.
Munson G.
Jaffe D.B.
Lui A.
Macdonald P.
Mauceli E.
Naylor J.W.
Nesbitt R.
Nicol R.
O'Leary S.B.
Ratcliffe A.
Rounsley S.
She X.
Sneddon K.M.
Stewart S.
Sougnez C.
Stone S.M.
Topham K.
Vincent D.
Wang S.
Zimmer A.R.
Birren B.W.
Hood L.
Lander E.S.
Nusbaum C.

Analysis of the DNA sequence and duplication history of human chromosome 15.

P:regulation of DNA-templated transcription

MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Characiformes Characoidei Acestrorhamphidae Acestrorhamphinae Astyanax

Cholesterol side-chain cleavage enzyme, mitochondrial

A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)

6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O

Lipid metabolism; C21-steroid hormone metabolism

Localizes to the matrix side of the mitochondrion inner membrane

Molecular and hormonal mechanisms underlying oocyte maturation and ovulation and its application to seed production in the lambari (Astyanax altiparanae).

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

P:C21-steroid hormone biosynthetic process

P:cellular response to peptide hormone stimulus

CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL


Helical

Disordered

Low complexity


Peptidase S1


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.


Terpene synthase N-terminal

Terpene synthase metal-binding

TERPENE SYNTHASE FAMILY, METAL-BINDING DOMAIN PROTEIN


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

VWFA

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the G-protein coupled receptor 1 family

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

Rhodopsin 7-helix transmembrane proteins

Family A G protein-coupled receptor-like


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Belongs to the protease inhibitor I19 family

Lacks conserved residue(s) required for the propagation of feature annotation

Pacifastin

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).

F:serine-type endopeptidase inhibitor activity


Cystatin

F:cysteine-type endopeptidase inhibitor activity


PID

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Low complexity

Polar residues

Low complexity

Basic residues

Low complexity

Basic and acidic residues

Low complexity

Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)


Signal transducer and activator of transcription 6

Belongs to the transcription factor STAT family

STAT transcription factor protein interaction

Disordered

Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team

Scherer S.E.
Muzny D.M.
Buhay C.J.
Chen R.
Cree A.
Ding Y.
Dugan-Rocha S.
Gill R.
Gunaratne P.
Harris R.A.
Hawes A.C.
Hernandez J.
Hodgson A.V.
Hume J.
Jackson A.
Khan Z.M.
Kovar-Smith C.
Lewis L.R.
Lozado R.J.
Metzker M.L.
Milosavljevic A.
Miner G.R.
Montgomery K.T.
Morgan M.B.
Nazareth L.V.
Scott G.
Sodergren E.
Song X.Z.
Steffen D.
Lovering R.C.
Wheeler D.A.
Worley K.C.
Yuan Y.
Zhang Z.
Adams C.Q.
Ansari-Lari M.A.
Ayele M.
Brown M.J.
Chen G.
Chen Z.
Clerc-Blankenburg K.P.
Davis C.
Delgado O.
Dinh H.H.
Draper H.
Gonzalez-Garay M.L.
Havlak P.
Jackson L.R.
Jacob L.S.
Kelly S.H.
Li L.
Li Z.
Liu J.
Liu W.
Lu J.
Maheshwari M.
Nguyen B.V.
Okwuonu G.O.
Pasternak S.
Perez L.M.
Plopper F.J.
Santibanez J.
Shen H.
Tabor P.E.
Verduzco D.
Waldron L.
Wang Q.
Williams G.A.
Zhang J.
Zhou J.
Allen C.C.
Amin A.G.
Anyalebechi V.
Bailey M.
Barbaria J.A.
Bimage K.E.
Bryant N.P.
Burch P.E.
Burkett C.E.
Burrell K.L.
Calderon E.
Cardenas V.
Carter K.
Casias K.
Cavazos I.
Cavazos S.R.
Ceasar H.
Chacko J.
Chan S.N.
Chavez D.
Christopoulos C.
Chu J.
Cockrell R.
Cox C.D.
Dang M.
Dathorne S.R.
David R.
Davis C.M.
Davy-Carroll L.
Deshazo D.R.
Donlin J.E.
D'Souza L.
Eaves K.A.
Egan A.
Emery-Cohen A.J.
Escotto M.
Flagg N.
Forbes L.D.
Gabisi A.M.
Garza M.
Hamilton C.
Henderson N.
Hernandez O.
Hines S.
Hogues M.E.
Huang M.
Idlebird D.G.
Johnson R.
Jolivet A.
Jones S.
Kagan R.
King L.M.
Leal B.
Lebow H.
Lee S.
LeVan J.M.
Lewis L.C.
London P.
Lorensuhewa L.M.
Loulseged H.
Lovett D.A.
Lucier A.
Lucier R.L.
Ma J.
Madu R.C.
Mapua P.
Martindale A.D.
Martinez E.
Massey E.
Mawhiney S.
Meador M.G.
Mendez S.
Mercado C.
Mercado I.C.
Merritt C.E.
Miner Z.L.
Minja E.
Mitchell T.
Mohabbat F.
Mohabbat K.
Montgomery B.
Moore N.
Morris S.
Munidasa M.
Ngo R.N.
Nguyen N.B.
Nickerson E.
Nwaokelemeh O.O.
Nwokenkwo S.
Obregon M.
Oguh M.
Oragunye N.
Oviedo R.J.
Parish B.J.
Parker D.N.
Parrish J.
Parks K.L.
Paul H.A.
Payton B.A.
Perez A.
Perrin W.
Pickens A.
Primus E.L.
Pu L.L.
Puazo M.
Quiles M.M.
Quiroz J.B.
Rabata D.
Reeves K.
Ruiz S.J.
Shao H.
Sisson I.
Sonaike T.
Sorelle R.P.
Sutton A.E.
Svatek A.F.
Svetz L.A.
Tamerisa K.S.
Taylor T.R.
Teague B.
Thomas N.
Thorn R.D.
Trejos Z.Y.
Trevino B.K.
Ukegbu O.N.
Urban J.B.
Vasquez L.I.
Vera V.A.
Villasana D.M.
Wang L.
Ward-Moore S.
Warren J.T.
Wei X.
White F.
Williamson A.L.
Wleczyk R.
Wooden H.S.
Wooden S.H.
Yen J.
Yoon L.
Yoon V.
Zorrilla S.E.
Nelson D.
Kucherlapati R.
Weinstock G.
Gibbs R.A.
null.

The finished DNA sequence of human chromosome 12.

F:DNA-binding transcription activator activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Signal transducer and transcription activator 6

STAT transcription factor, all-alpha domain

STAT transcription factor, DNA-binding domain

SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION


PCNA-associated factor histone-like

Disordered

Low complexity

Low complexity

Low complexity


Eukaryota
Metazoa
Spiralia
Lophotrochozoa
Mollusca
Cephalopoda
Coleoidea
Decapodiformes
Decapodiformes incertae sedis
Idiosepiidae
Xipholeptos

Helical

Helical

Helical

Koller D.
Kocot K.M.
Degnan B.M.
Wollesen T.

Developmental gene expression in the eyes of the pygmy squid Xipholeptos notoides.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Thysanoptera Terebrantia Thripoidea Thripidae Thrips