{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1F3", "uniProtkbId": "A0AAU7P1F3_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30726.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30726.1"}], "value": "Low density lipoprotein receptor"}}], "flag": "Fragment"}, "features": [{"type": "Region", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 86, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30726.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 103, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30726.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30726.1"}], "id": "KW-0449", "category": "PTM", "name": "Lipoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30726.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30726.1"}], "value": "2", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30726.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892382", "properties": [{"key": "ProteinId", "value": "XBS30726.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "SLSPPRTQVWKPLSLMPYIWRQEPEHGKRQMPDENPGVAPVSRACAGCPNTARRGMAFYTVPGEDEKERPAPAPLRRRQVQSVLSAGRPMATVCRAGGGQLEG", "length": 103, "molWeight": 11279, "crc64": "20239BA32EACC837", "md5": "E2D82B38AD57CC3B9A2E9BB9818DA231"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D33704"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96UTL3", "uniProtkbId": "A0AA96UTL3_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29083.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29083.1"}], "value": "CREWS-C3"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 261, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041698478"}, {"type": "Domain", "location": {"start": {"value": 86, "modifier": "EXACT"}, "end": {"value": 168, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Region", "location": {"start": {"value": 171, "modifier": "EXACT"}, "end": {"value": 261, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 183, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 211, "modifier": "EXACT"}, "end": {"value": 231, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29083.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651420", "properties": [{"key": "ProteinId", "value": "WNX29083.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLLFHLFLLFVILCSSAAKRDLSCTKPDIRVLVDADVGQLDNYAISLMSKFIETPEEKDVTKFTHCDAHTAIENASKSIPDGKEGVIVFVTTKNNTVTTKALKAAKEVHYRKNLLLFAVGVGSDVNNTILEKLRRLATSIDPRSKQFVYTYKDIADLYIDQSKLATRICEGGNVTKPDTTKPAKPKPGRGRRPKANLATATSAEEESAKGRPSKAKRAGKPAKVGAKKPKPGHKDNIKLVNTVKPAVKPAIRTTRPPGTRG", "length": 261, "molWeight": 28474, "crc64": "8A064A3473628BA2", "md5": "B48C989EA211D36A622F16F3364A4198"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 2}, "uniParcId": "UPI002B2C8FD0"}, "cluster_size": 1, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QK75", "uniProtkbId": "A0AAU0QK75_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56425.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56425.1"}], "value": "Chemosensory protein"}}]}, "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56425.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56425.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970416", "properties": [{"key": "ProteinId", "value": "WPO56425.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.2080.10", "properties": [{"key": "EntryName", "value": "Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005055", "properties": [{"key": "EntryName", "value": "A10/PebIII"}]}, {"database": "InterPro", "id": "IPR036682", "properties": [{"key": "EntryName", "value": "OS_D_A10/PebIII_sf"}]}, {"database": "PANTHER", "id": "PTHR11257", "properties": [{"key": "EntryName", "value": "CHEMOSENSORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11257:SF13", "properties": [{"key": "EntryName", "value": "GEO07322P1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03392", "properties": [{"key": "EntryName", "value": "OS-D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF100910", "properties": [{"key": "EntryName", "value": "Chemosensory protein Csp2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDCFLDKGPCTPLGRVFKFALPEVVKTGCSKCTPAQRSFARRTFDAFKRNLPEQHEELKKLLDPDNKYYDKFEKAIAIA", "length": 79, "molWeight": 9085, "crc64": "4EF2E3CDD703A541", "md5": "BF2C36BDA74D2834520B335928CF0020"}, "extraAttributes": {"uniParcId": "UPI00308DA5A7"}, "cluster_size": 2, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MPK7", "uniProtkbId": "A0AA96MPK7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50049.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50049.1"}], "value": "Uncharacterized protein 7"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041697206"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50049.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460126", "properties": [{"key": "ProteinId", "value": "WNS50049.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MKAFAALIAILSVLVARLDGGPVQELSDKAIAELQVLADRECPKLQGKGYDKFETQSKLNSQLNPVGRSIQFCESFGYHVDLPTCDDEGSVDDTYYLMWTTSGSVVGWMCEWGSVF", "length": 116, "molWeight": 12789, "crc64": "A243D1D22C6DFB9D", "md5": "E987E9C5925E7D02ECE2FF5CF4F5A664"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B2CC3AA"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU75", "uniProtkbId": "A0AAT9UU75_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41660.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41660.1"}], "value": "Cytochrome P450 404E1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 439, "modifier": "EXACT"}, "end": {"value": 439, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41660.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117220", "properties": [{"key": "ProteinId", "value": "WIM41660.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11054", "properties": [{"key": "EntryName", "value": "CYP24A1-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050479", "properties": [{"key": "EntryName", "value": "CYP11_CYP27_families"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "PANTHER", "id": "PTHR24279", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24279:SF120", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRNRFLRPICTQAVPYTKSFDSIPRPFQLPLLGNWHLYKLGIYNPRKYHQVLLDLYKHYGPVVYEKVGLDKPIIHVFEPDDVQTVYRNEDKTPRIFPLSEFTKAYRQQERMSTGLGNTNDDEWYRLKNGIRHLMLKTNSVQRFLKDTETVTDDLVEVIKKYRDDQGRIGDLRQLLGRWSQEVAGQICFDKRLGYLCGPNESLGKRIVQANETVFRLGALLKFSLPIYNYIRTPKWMKLVENEHIVHKTALQYINESFTRIDKLLETNSIKDDQYTFLITLLQKDELSRKDVTVITTSLFIDGLSTTVPVLINNLYSLATNQQVQEKAYQEICRVCSDKDDLDAGTLNKLTYLKAIIKETFRMYPNGTEVARINKKPLILSNYEIPPESNLSMNMLVHFKSPKYFSDPETFKPERWLRGAENSPIHPFLLTPFGHGARTCAGRKFAEQDLLVSLYKIVKNFKLIYPSNGPRIDFVFDTLIFPDKDLPINFIPR", "length": 492, "molWeight": 57337, "crc64": "FCB14E64935F35A5", "md5": "E346A6DA9C8FA49BEA00968F1919634D"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D26F8F"}, "cluster_size": 4, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QK09", "uniProtkbId": "A0AAU0QK09_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56501.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56501.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 48, "modifier": "EXACT"}, "end": {"value": 70, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 118, "modifier": "EXACT"}, "end": {"value": 118, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56501.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56501.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56501.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56501.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970394", "properties": [{"key": "ProteinId", "value": "WPO56501.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MNSRYLKLLLSLGHCTLTAWFLYPLIDDLEYNLFLEIRLPFNYRSPSSYVFAYFLVGIAFVYISHFVMVIDLIMQAHLLHLVCQLAVLRDCIENAFEECAEGFGDQDLDTFVTDDRFR", "length": 118, "molWeight": 13829, "crc64": "A84B1F89912EE4B3", "md5": "944F5FA43E2550405025F879A2198532"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00308EF6DA"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU18", "uniProtkbId": "A0AAT9UU18_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41622.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41622.1"}], "value": "Cytochrome P450 6PZ15 short isoform"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41622.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117182", "properties": [{"key": "ProteinId", "value": "WIM41622.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002402", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-II"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00464", "properties": [{"key": "EntryName", "value": "EP450II"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDTIEILFCAIFLSIIYLYYRFKNNYTYFERNGIPYIKPVLFFGNVADWVFMKKPLPVVHFELYKKLEPHSFAGVYLGGKKTFLIRDAELVKNILVKDFACFRDRGIKRDPHDILSRNLFMMRGDDWKNLRIKLTSTFTSGKMKMMFPLVDECGSRLHEKMQKITDTDILIKDVCSRFTTDVIGSCAFGLEINSLDDPDSEFRKIGNRILDSSFTPVFRSIMRNMLPAVAKLSKHLHTDTTVQDFFVDLVQKTVKYREDNKIKRGDFLDLLINLKNDTSSQKSNDQQVQEDLTKFLDQLGENHVKSNIGKSSFTFIQPLNSSHSPSSHDLRVNDRSMLCILHRRFRDILEHPELHVTRTIPTSRYPTKSSSRNHHRIAKARQSVKLRYVEGTQILRFGYRGNPAKIPNHR", "length": 410, "molWeight": 47784, "crc64": "E10D12C8A2BD4C2F", "md5": "29945FE4351D41F7F1FC14063506330A"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI0035D3AEC5"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU66", "uniProtkbId": "A0AAT9UU66_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41645.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41645.1"}], "value": "Cytochrome P450 6AED1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 45, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 484, "modifier": "EXACT"}, "end": {"value": 484, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41645.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117205", "properties": [{"key": "ProteinId", "value": "WIM41645.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000042", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEAHSYINSKYHFLSHFFHVSKMGLTVVLLLLIIVGSILQSYWFFKKSYRFFDENHFPTLKPTFVFGNLGDAITFKKSLALTIYDLYNKLEAHKFAGLYMLHRPFVMIRDAELIKNILIKDFVYFRDRGIACKEDAEPLNNNLLRIDGDRWKSLRVKLTPIFSPNKMKLMFVPIQENSKKLVQILNSTKGESFDMKELSERFTTDVIGNCAFGIETRALENPDSIVREMGKRIFEFRYQTLIRHLFPHLPSILVKIFKLTYLNKIVESFFIKMLRETIEQREKSSVSRKDLLELLIALKNETSDIYPNKDVEQFLSQINDNNVKNETGLTMDLIIAQCYLFFAAGFETSSSSLGYVMLELALNKNVQNTARNEIIKVLSENGGEITYDSLKDMTYADMVIAETLRKHPPAGFLLRKCTKSYQIPDTEAIIPQNTLIFISIYGVHMDRKYYEKPEQFYPEHFEEEARNKRPKCAFIPFGDGPRNCIGERFAKLEIKIGMIHMLMNHSFDVSPQMKLPLEYNYDSTLGLMSVKGGIWLRCQKI", "length": 541, "molWeight": 62896, "crc64": "3632B643E8881755", "md5": "8CAFC1A3D9D35C93154A153BB6A21DCA"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D3C9DA"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N6K8", "uniProtkbId": "A0AAJ6N6K8_PHYCP", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Phytophthora capsici LT1534", "taxonId": 763924, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8WOJ"}], "lineage": ["Eukaryota", "Sar", "Stramenopiles", "Oomycota", "Peronosporales", "Peronosporaceae", "Phytophthora"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8WOJ"}], "value": "RxLR121 effector"}}]}, "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8WOJ"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-643BSTAP6LOFA", "citationType": "submission", "authors": ["Yang C.C.", "Zhang X.G."], "title": "Structure of RxLR121 effector from phytophthora capsici.", "publicationDate": "OCT-2023", "submissionDatabase": "PDB data bank"}, "referencePositions": ["X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS)"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8WOJ"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8WOJ", "properties": [{"key": "Method", "value": "X-ray"}, {"key": "Resolution", "value": "1.77 A"}, {"key": "Chains", "value": "A/B=1-76"}]}, {"database": "SMR", "id": "A0AAJ6N6K8", "properties": [{"key": "Description", "value": "-"}]}], "sequence": {"value": "AFTYTFNFSLWDDLFNSLPEQFQRMRKEPWYLRRIFRSWRSGMGTSDEAVAYMRSQGLSQKAIDQFEDAYIKYRAH", "length": 76, "molWeight": 9257, "crc64": "049FC2750AB7F4BC", "md5": "A767A777878FFBF8F42478133A2E639C"}, "extraAttributes": {"uniParcId": "UPI002A6B906C"}, "cluster_size": 1, "family": "Peronosporaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHT9", "uniProtkbId": "A0AAQ5BHT9_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519556.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519556.1"}], "value": "SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519556.1"}], "value": "SPNS3"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00024338"}], "value": "Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 65, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 85, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 112, "modifier": "EXACT"}, "end": {"value": 131, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 137, "modifier": "EXACT"}, "end": {"value": 161, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 47, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "Major facilitator superfamily (MFS) profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50850"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 30, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHT9"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHT9"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519556.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519556.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16625196", "citationType": "journal article", "authors": ["Zody M.C.", "Garber M.", "Adams D.J.", "Sharpe T.", "Harrow J.", "Lupski J.R.", "Nicholson C.", "Searle S.M.", "Wilming L.", "Young S.K.", "Abouelleil A.", "Allen N.R.", "Bi W.", "Bloom T.", "Borowsky M.L.", "Bugalter B.E.", "Butler J.", "Chang J.L.", "Chen C.K.", "Cook A.", "Corum B.", "Cuomo C.A.", "de Jong P.J.", "DeCaprio D.", "Dewar K.", "FitzGerald M.", "Gilbert J.", "Gibson R.", "Gnerre S.", "Goldstein S.", "Grafham D.V.", "Grocock R.", "Hafez N.", "Hagopian D.S.", "Hart E.", "Norman C.H.", "Humphray S.", "Jaffe D.B.", "Jones M.", "Kamal M.", "Khodiyar V.K.", "LaButti K.", "Laird G.", "Lehoczky J.", "Liu X.", "Lokyitsang T.", "Loveland J.", "Lui A.", "Macdonald P.", "Major J.E.", "Matthews L.", "Mauceli E.", "McCarroll S.A.", "Mihalev A.H.", "Mudge J.", "Nguyen C.", "Nicol R.", "O'Leary S.B.", "Osoegawa K.", "Schwartz D.C.", "Shaw-Smith C.", "Stankiewicz P.", "Steward C.", "Swarbreck D.", "Venkataraman V.", "Whittaker C.A.", "Yang X.", "Zimmer A.R.", "Bradley A.", "Hubbard T.", "Birren B.W.", "Rogers J.", "Lander E.S.", "Nusbaum C."], "citationCrossReferences": [{"database": "PubMed", "id": "16625196"}, {"database": "DOI", "id": "10.1038/nature04689"}], "title": "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.", "publicationDate": "2006", "journal": "Nature", "firstPage": "1045", "lastPage": "1049", "volume": "440"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519556.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519556.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC116910", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AC127521", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHT9", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714275.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519556.1"}, {"key": "GeneId", "value": "ENSG00000182557.9"}]}, {"database": "HGNC", "id": "HGNC:28433", "properties": [{"key": "GeneName", "value": "SPNS3"}]}, {"database": "OpenTargets", "id": "ENSG00000182557", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000005976", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 17"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0022857", "properties": [{"key": "GoTerm", "value": "F:transmembrane transporter activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.20.1250.20", "properties": [{"key": "EntryName", "value": "MFS general substrate transporter like domains"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR011701", "properties": [{"key": "EntryName", "value": "MFS"}]}, {"database": "InterPro", "id": "IPR020846", "properties": [{"key": "EntryName", "value": "MFS_dom"}]}, {"database": "InterPro", "id": "IPR044770", "properties": [{"key": "EntryName", "value": "MFS_spinster-like"}]}, {"database": "InterPro", "id": "IPR036259", "properties": [{"key": "EntryName", "value": "MFS_trans_sf"}]}, {"database": "PANTHER", "id": "PTHR23505:SF3", "properties": [{"key": "EntryName", "value": "PROTEIN SPINSTER HOMOLOG 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23505", "properties": [{"key": "EntryName", "value": "SPINSTER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07690", "properties": [{"key": "EntryName", "value": "MFS_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF103473", "properties": [{"key": "EntryName", "value": "MFS general substrate transporter"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50850", "properties": [{"key": "EntryName", "value": "MFS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAGGMSAECPEPGPGGLQGQSPGPGRQCPPPITPTSWSLPPWRAYVAAAVLCYINLLNYMNWFIIAGVLLDIQEVFQISDNHAGLLQTVFVSCLLLSAPVFGYLGDRHSRKATMSFGILLWSGAGLSSSFISPRYSWLFFLSRGIVGTGSASYSTIAPTVLGDLFVRDQRTRVLAVFYIFIPVGRSCPAWRPWP", "length": 194, "molWeight": 21088, "crc64": "B81F9C070E81EF8A", "md5": "5EE3921E8A7D89AECCB9A2BAF2D2DEE1"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 4, "Domain": 1, "Region": 1}, "uniParcId": "UPI0032C70D40"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NNI7", "uniProtkbId": "A0AA96NNI7_PAELC", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia lactiflora", "commonName": "Chinese peony", "synonyms": ["Paeonia albiflora"], "taxonId": 35924, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94117.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94117.1"}], "value": "Uncharacterized protein"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 88, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 46, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 46, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94117.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-816JBB05UD0I7", "citationType": "submission", "authors": ["Shi Y.J."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94117.1"}], "value": "S-SPD A", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94117.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR552630", "properties": [{"key": "ProteinId", "value": "WNT94117.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "TKRNPDNPVSLSRSGGSEDEHRISTKRNPDNPVSLSRSGGSKGSSSLSFTTFNSYFNLFLLQNPKYQFVLIVLYFWIVRLSSDVFCYVHDSYLASMVGMIYI", "length": 102, "molWeight": 11553, "crc64": "61E17264CC67F7DE", "md5": "8FBF3A2749267143BFC0D63C8523D9C3"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Region": 1, "Compositional bias": 2, "Non-terminal residue": 1}, "uniParcId": "UPI002B2BE565"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9PAT4", "uniProtkbId": "A0AAT9PAT4_SCYPA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Scylla paramamosain", "commonName": "Mud crab", "taxonId": 85552, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UDM59913.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Portunoidea", "Portunidae", "Portuninae", "Scylla"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UDM59913.1"}], "value": "Scybaumancin"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 30, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AIIQ1SCSBITLU", "citationType": "submission", "authors": ["Wang K.", "Zhou Y.", "Chen F.", "Liu J."], "publicationDate": "JUL-2020", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UDM59913.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "MT707607", "properties": [{"key": "ProteinId", "value": "UDM59913.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MCVGASRLPPSSPPLTSTPAAAATTTEATPQPQHALSSLPPVHSCPSHHQTPGSKERGGRRPPQRQEQSRRSPHSPPCALGARPAAALQPATSQPPDTRSHCRTVVTCRLAHMALKSAKSSRSLLCHVY", "length": 129, "molWeight": 13617, "crc64": "38D04E97A2A7C216", "md5": "5128B9C41D5D4350D1551876B53E91D3"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D2E5AA"}, "cluster_size": 1, "family": "Portunidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEG6", "uniProtkbId": "A0AB38ZEG6_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02683.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02683.1"}], "value": "Venom redulysin 7"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 433, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044251791"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02683.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517433", "properties": [{"key": "ProteinId", "value": "WXI02683.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSKLWLLLLLVAAFQNINAYPAEYEIDDDDYGYMSEEAEEDLEYYTSTEDDDYMSDEQSTWGILTDAWGKLKDKYSKITAAKLKKIIVSIKNKFCTQQEDFEDDLQSDEAQDSLSIQYKIVQNIRERYKAAKAKWGNKKEKFNEALAKIKAEFCGKLKDYAEESDFYEDDDDGDEERFNWGSITKGLKKAGQTMAKGMKTAGKSMAKGLKTAGKNVAKGMKTAGKNMAKGMKTAGKSMVKGLKTAAKKLKKLKEPMKKLMKKGATLLKNAGIKIRPLQCEEKTCQSCIVLTIPTEISFCVKMTFMKTNKATYLIIHLTKNDEVLLEKKLIIGEVPHCVYAGSLIGDICLKGIEGHAKSSKGQLNANICLVIVTPNWGIASKLCAVYEDKKLRVKFEPTAFPAVKDEDGEIVEMTENGEEGAAVDADEEEVEVD", "length": 433, "molWeight": 48334, "crc64": "F10D5F76A78BD0D6", "md5": "11BEA3BE33594B369D45F7035124DFEB"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BE5C5"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMS6", "uniProtkbId": "A0AAU0QMS6_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56506.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56506.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 42, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56506.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56506.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56506.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56506.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970399", "properties": [{"key": "ProteinId", "value": "WPO56506.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIMHHKEIVNMADKIQDIFGGAVFYQFLVSGWILCTSVYRIANVS", "length": 45, "molWeight": 5147, "crc64": "D6450B375CF9A22C", "md5": "14713BC5634A676EA3108B62B69ACF98"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0030901000"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QP32", "uniProtkbId": "A0AAU0QP32_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56466.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56466.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 51, "modifier": "EXACT"}, "end": {"value": 71, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 112, "modifier": "EXACT"}, "end": {"value": 145, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 205, "modifier": "EXACT"}, "end": {"value": 226, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 238, "modifier": "EXACT"}, "end": {"value": 260, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56466.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56466.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56466.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970359", "properties": [{"key": "ProteinId", "value": "WPO56466.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNIIAVSRLTLLFNKKYYEIVSDFFLKIHLFHYKDQSDYAMKTHLLIHKRSHFIVMFVYTAMWSGNVMFHVPPLYKNYKSGMLFNPSDENGTFEHALYWTLPFDYTTNYKGIIFVALFNMYICYICSTLVGVLDVLLCIMVFHLWGHLKIFIHNLEEFPKPKHMINSLVGEWYTEEENRNVKTKLKSIIAYHNILIKFVARMSKVFGGILFVYYGFHQVCGCLLLLECSQLEMSAFMLYGPLTVTLNVLLIQLSTIFDLLESTTMKITTAIYNLPWESMDTPNRRIVNSMLRQSLKPITIKALDMLDVGCTTMITIFKNSFSYFIMLRTVANKD", "length": 334, "molWeight": 39047, "crc64": "C098286AEA826FF7", "md5": "51605F20E1BB234661431AD4977224FC"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 4}, "uniParcId": "UPI00308FCACD"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P7M0", "uniProtkbId": "A0AAF0P7M0_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Tenuipotamon huaningense", "taxonId": 511399, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59257.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00040357"}], "value": "2-phosphoxylose phosphatase 1"}}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00041499"}], "value": "Acid phosphatase-like protein 2"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59257.1"}], "value": "scaffold2066371"}}], "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:56512"}, {"database": "Rhea", "id": "RHEA-COMP:12573"}, {"database": "Rhea", "id": "RHEA-COMP:14559"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:43474"}, {"database": "ChEBI", "id": "CHEBI:132093"}, {"database": "ChEBI", "id": "CHEBI:140495"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00036311"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005375"}], "value": "Belongs to the histidine acid phosphatase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59257.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 295, "modifier": "EXACT"}, "end": {"value": 295, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59257.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59257.1"}], "value": "HNHX", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59257.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59257.1"}], "value": "HNHX", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59257.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515380", "properties": [{"key": "ProteinId", "value": "WMS59257.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005794", "properties": [{"key": "GoTerm", "value": "C:Golgi apparatus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016791", "properties": [{"key": "GoTerm", "value": "F:phosphatase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0050650", "properties": [{"key": "GoTerm", "value": "P:chondroitin sulfate proteoglycan biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006024", "properties": [{"key": "GoTerm", "value": "P:glycosaminoglycan biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd07061", "properties": [{"key": "EntryName", "value": "HP_HAP_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.1240", "properties": [{"key": "EntryName", "value": "Phosphoglycerate mutase-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000560", "properties": [{"key": "EntryName", "value": "His_Pase_clade-2"}]}, {"database": "InterPro", "id": "IPR029033", "properties": [{"key": "EntryName", "value": "His_PPase_superfam"}]}, {"database": "InterPro", "id": "IPR050645", "properties": [{"key": "EntryName", "value": "Histidine_acid_phosphatase"}]}, {"database": "PANTHER", "id": "PTHR11567:SF110", "properties": [{"key": "EntryName", "value": "2-PHOSPHOXYLOSE PHOSPHATASE 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11567", "properties": [{"key": "EntryName", "value": "ACID PHOSPHATASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00328", "properties": [{"key": "EntryName", "value": "His_Phos_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53254", "properties": [{"key": "EntryName", "value": "Phosphoglycerate mutase-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "FVGPFVRFPLLPPPAHCGLGHLTPQGVLQHLQLGRVLRQVYLTEFNLLGNQWEQDDILVFCTKYRRTFQSVLAFLYSFIPDFHISKVRLQEGRGVSFCGDDCRCEQSDHYDQKYEEERRDYRRSHPGIVDLVHRVNPLVREGEDITSPLVMRDALLSYVCHGASLPCVAGRCVRVEDVTGLVSYEEWEGRQKRTSAQRKAAKLRVYGLMKSISSALNGMMGDSRPRVVVYSGHDRTLKYLLDTLSIPNYQLPYYASRLVLELYQNASATHDPDYHATYYFRLVYNGKDITKFIPF", "length": 295, "molWeight": 34007, "crc64": "D345F89C69C265EA", "md5": "671C2FF827E4640368D6F9E1F26723AE"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI002B2D8D32"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAD9KTI0", "uniProtkbId": "A0AAD9KTI0_RIDPI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ridgeia piscesae", "commonName": "Tubeworm", "taxonId": 27915, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176610.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001209878"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Sedentaria", "Canalipalpata", "Sabellida", "Siboglinidae", "Ridgeia"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}], "value": "Ig-like domain-containing protein"}}}, "genes": [{"orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176610.1"}], "value": "NP493_652g02015"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176610.1"}], "value": "The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}], "commentType": "CAUTION"}], "features": [{"type": "Domain", "location": {"start": {"value": 272, "modifier": "EXACT"}, "end": {"value": 360, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047216"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001209878"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}], "references": [{"referenceNumber": 1, "citation": {"id": "37494294", "citationType": "journal article", "authors": ["Perez M.", "Aroh O.", "Sun Y.", "Lan Y.", "Juniper S.K.", "Young C.R.", "Angers B.", "Qian P.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37494294"}, {"database": "DOI", "id": "10.1093/molbev/msad172"}], "title": "Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.", "publicationDate": "2023", "journal": "Mol. Biol. Evol.", "firstPage": "msad172", "lastPage": "msad172", "volume": "40"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176610.1"}], "value": "R07B-5", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176610.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "JAODUO010000651", "properties": [{"key": "ProteinId", "value": "KAK2176610.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP001209878", "properties": [{"key": "Component", "value": "Unassembled WGS sequence"}]}, {"database": "CDD", "id": "cd00096", "properties": [{"key": "EntryName", "value": "Ig"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.20.100.10:FF:000007", "properties": [{"key": "EntryName", "value": "Thrombospondin 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.1120", "properties": [{"key": "EntryName", "value": "Carboxypeptidase-like, regulatory domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.20.100.10", "properties": [{"key": "EntryName", "value": "Thrombospondin type-1 (TSP1) repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008969", "properties": [{"key": "EntryName", "value": "CarboxyPept-like_regulatory"}]}, {"database": "InterPro", "id": "IPR056255", "properties": [{"key": "EntryName", "value": "CILP-1/2_dom"}]}, {"database": "InterPro", "id": "IPR039675", "properties": [{"key": "EntryName", "value": "CILP1/CILP2"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR000884", "properties": [{"key": "EntryName", "value": "TSP1_rpt"}]}, {"database": "InterPro", "id": "IPR036383", "properties": [{"key": "EntryName", "value": "TSP1_rpt_sf"}]}, {"database": "PANTHER", "id": "PTHR15031:SF6", "properties": [{"key": "EntryName", "value": "CARTILAGE INTERMEDIATE LAYER PROTEIN 1-LIKE ISOFORM X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR15031", "properties": [{"key": "EntryName", "value": "CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13620", "properties": [{"key": "EntryName", "value": "CarboxypepD_reg"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23708", "properties": [{"key": "EntryName", "value": "CILP_5th"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13927", "properties": [{"key": "EntryName", "value": "Ig_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00090", "properties": [{"key": "EntryName", "value": "TSP_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01705", "properties": [{"key": "EntryName", "value": "TSP1REPEAT"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00209", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49464", "properties": [{"key": "EntryName", "value": "Carboxypeptidase regulatory domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF82895", "properties": [{"key": "EntryName", "value": "TSP-1 type 1 repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50092", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYLCVEDSSGGLVINGQWSVWDPWSSCSVTCDGGTQQRVRRCDDPAPQNGGSECVGVSSEGRPCDQWACPDCSRTCPPGGHLDPDCSVCQCDSDVIEGRVTDRQTSLPLADVNIFTVGREWSAAAVSGRDGRFTLSGVCVSGLRLTARKDGYESATQEYVVIAGSSVSVVMYKLGEYIVIGEYIVSVVMYKLGEYVVSVVTYKLGESSYKLGSTHQCGHVQSEYVVSVVMYKLGEYVVNVVTYKLGQYVISVVTYKLGQYVVNVVTYKLEKPMFSMEPRSTAGFVGGKVRFSCQATAEPDVTQYDWFKDGHIIRSDVVGGSGNSGSVYEVANVKADDVGHYVCRAVSLGGKIFSRVASLVVKDASATDTCDKSPLDLSVTLPPTCKVTIDGTKVSSVNVGRCSHVPCVTRTSSDSEGLCCVPSSMRQLQVECDGFSYEVNQVASCECARCDDNKKVTVTGRASSGGADVTDVHVLYDDVIYDVTNSQFLFEATPRAGVIVFQVKSSSFMPRLVTLDVNEGVAQVYVEVSLVARPSPDVVDAATGAKLQVVTPGMSSAVSVTIPPGAFNDKNGDPVSGNVNVFLSISDPRLPDGLDSASGQFTFQDSEGDTRLLKTFGVVTLLAEDTNGNEVYLSGKATMTLNTDAMGLTVGESVSLWVIDGASGTWRKTVDMMTGSRRRRRRQVSMGSTLTGQTAIPRNVPVVNCDVPVPRPFCFVAVYVYFGSDFSVPMPGERVTATGFDSETGVASFQNTATTDQNGRACLFVACGTKYLLKMFSRGGITVHPTHSLPVGFPFANVFNGVTFTTTPPANQADYANGPVFINQEFSSACPATTQFFFKFGVVLTRPSLYGSLNAGPGWYPDQPAEAPACAYLVVLNLPNVGTTSHRTYSC", "length": 891, "molWeight": 95404, "crc64": "C1859D7032AF5D8A", "md5": "A625E781B99D268C8EEFFE1CA6590550"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0028843259"}, "cluster_size": 2, "family": "Siboglinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6NDJ6", "uniProtkbId": "A0AAU6NDJ6_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59754.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59754.1"}], "value": "CSP5"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59754.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59754.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420114", "properties": [{"key": "ProteinId", "value": "WWA59754.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.2080.10", "properties": [{"key": "EntryName", "value": "Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005055", "properties": [{"key": "EntryName", "value": "A10/PebIII"}]}, {"database": "InterPro", "id": "IPR036682", "properties": [{"key": "EntryName", "value": "OS_D_A10/PebIII_sf"}]}, {"database": "PANTHER", "id": "PTHR11257", "properties": [{"key": "EntryName", "value": "CHEMOSENSORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03392", "properties": [{"key": "EntryName", "value": "OS-D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF100910", "properties": [{"key": "EntryName", "value": "Chemosensory protein Csp2"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "SQKLKVIPEALESTCGKCSPKQKQLILESTCGKCSPKQKQLIRMVVKAVMASHPEAWQKLTDKFDKDRKFKASFDKFLAEEN", "length": 82, "molWeight": 9328, "crc64": "304B456B524493C5", "md5": "64387B1409A07D46310E307418753D0F"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D274F0"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NDT4", "uniProtkbId": "A0AA96NDT4_9MAGN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Corydalis yanhusuo", "taxonId": 458692, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT44090.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Ranunculales", "Papaveraceae", "Fumarioideae", "Corydalis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT44090.1"}], "value": "CYP82BD1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004913"}], "value": "Alkaloid biosynthesis"}], "commentType": "PATHWAY"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004370"}], "value": "Membrane", "id": "SL-0162"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 43, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 367, "modifier": "EXACT"}, "end": {"value": 385, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 512, "modifier": "EXACT"}, "end": {"value": 512, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7U5ELI1R3HKK0", "citationType": "submission", "authors": ["Liu X."], "publicationDate": "FEB-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT44090.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ434212", "properties": [{"key": "ProteinId", "value": "WNT44090.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0033075", "properties": [{"key": "GoTerm", "value": "P:isoquinoline alkaloid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050651", "properties": [{"key": "EntryName", "value": "Plant_Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR47947:SF26", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47947", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 82C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDLPLSSSSLLVFLSDQWSTISAHPLLAYVLFFCFIFYIIHLIRRPSSSKKKQRVLAEPPKVAGAWPLIGHIDLLSLPFEKFGDMVDTYGPIYRIQLGIRETVVINNSETAKECFTTHDKLFSNRPLPFNHKYGFNNDYSFNHIPHGSLWRDFRKIASVGLFSRIRIEMQRHIRTSEVNLWCNHLYMLWKKDERTRGGEKGPAVLVEISSWARNLFFFVLFDFIIGVDNGDHDQQQNGGLSLKDMGKKYKKVMDEMVHLMETTFPISDLIPFLEWYDKLTGKNTALEKKAKEMDSFLDMWLQEHRRRRHLSRTTSVIVDNNISDNQDQDGQVKSYMDIMLSTIDKDPQYVGLDTDVIIKTACQDMMFGGYQTITIALPWALFFLMNNRHVLDKARKELDEQIGKERQVEESDLKQLPYLQTILKETMRLYIPAADFLARVPSEDCEVGGFHVKAGTTVIINLRKIHQDPKIWPDSTFEFKPERFLIGSTNEGVDVKGQNFELFPFGTGRRMCPAVTFSLRLMNLVLARLIHGFELNIPMPDGTADTSVGASIPLIDRKMDHLPLLISPRLASEAYAVKH", "length": 579, "molWeight": 66645, "crc64": "8EC37CF4079936E4", "md5": "6B48B8AE798B71400C163736FD47CEF2"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "PATHWAY": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 2, "Binding site": 1}, "uniParcId": "UPI002B2DB990"}, "cluster_size": 2, "family": "Papaveraceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BIB7", "uniProtkbId": "A0AAQ5BIB7_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520341.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520341.1"}], "value": "YY1 associated protein 1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520341.1"}], "value": "YY1AP1"}}], "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 31, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BIB7"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BIB7"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520341.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520341.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520341.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520341.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL162734", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "BX088689", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BIB7", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000715140.1", "properties": [{"key": "ProteinId", "value": "ENSP00000520341.1"}, {"key": "GeneId", "value": "ENSG00000163374.21"}]}, {"database": "HGNC", "id": "HGNC:30935", "properties": [{"key": "GeneName", "value": "YY1AP1"}]}, {"database": "OpenTargets", "id": "ENSG00000163374", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000016256", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR052435", "properties": [{"key": "EntryName", "value": "YY1-Transcr_Regul"}]}, {"database": "PANTHER", "id": "PTHR16088:SF3", "properties": [{"key": "EntryName", "value": "GON-4-LIKE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR16088", "properties": [{"key": "EntryName", "value": "YY1 ASSOCIATED PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEDLFETFQDEMGFSNMEDDGPEEEERVAEPQANFNTPQALRFEELLANLLNEQHQIAKELFEQLKMKKPSAKQQKEVEKVKPQCKEVHQTLILDPAQRKRLQQQMQQRQGSLC", "length": 114, "molWeight": 13416, "crc64": "78C27D56A1E71341", "md5": "7313E876044AAD48EB40B877ABD4D6F6"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0032CBB8D2"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6SGY2", "uniProtkbId": "A0AAU6SGY2_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32408.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32408.1"}], "value": "Protein takeout"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00060902"}], "value": "Belongs to the TO family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023108"}], "id": "KW-0090", "category": "Biological process", "name": "Biological rhythms"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B0NSJ4HC5RLL1", "citationType": "submission", "authors": ["S S.B.", "Negi N.", "Nagarjuna Reddy K.", "R G.G."], "title": "Takout-proteins of Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32408.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR247751", "properties": [{"key": "ProteinId", "value": "WZP32408.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007623", "properties": [{"key": "GoTerm", "value": "P:circadian rhythm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "3.15.10.30:FF:000001", "properties": [{"key": "EntryName", "value": "Takeout-like protein 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.15.10.30", "properties": [{"key": "EntryName", "value": "Haemolymph juvenile hormone binding protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR010562", "properties": [{"key": "EntryName", "value": "Haemolymph_juvenile_hormone-bd"}]}, {"database": "InterPro", "id": "IPR038606", "properties": [{"key": "EntryName", "value": "To_sf"}]}, {"database": "PANTHER", "id": "PTHR11008:SF39", "properties": [{"key": "EntryName", "value": "CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11008", "properties": [{"key": "EntryName", "value": "PROTEIN TAKEOUT-LIKE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF06585", "properties": [{"key": "EntryName", "value": "JHBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00700", "properties": [{"key": "EntryName", "value": "JHBP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKESLERLRPFLKTGIPELSIPSFEPLILPEITLNQGKGPINLQTTFNNLHLWGLSVFDIKEFRSKMESNQLKFKLLYPYLMSKSIYRINGRVLMLPIEGDGVSEGNYTNVESVVQIQGSRIRQNGNTFFFVEKATVSLDVSHVSIYFDNLFNGDKELGDSMNTFLNDNWKSIMKDMRPVFEESIGAMVKELFNSMYNKLPLEEILPL", "length": 208, "molWeight": 23911, "crc64": "7C6A2F0C5A72328C", "md5": "1B0AC9259684CC7BDF44F545B36684CF"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0035D3B2D7"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38Z7E4", "uniProtkbId": "A0AB38Z7E4_PAESU", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Paeonia suffruticosa", "commonName": "Tree peony", "synonyms": ["Paeonia moutan"], "taxonId": 45171, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20331.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011883"}], "value": "acetyl-CoA carboxytransferase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011883"}], "value": "2.1.3.15"}]}}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA = N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:54728"}, {"database": "Rhea", "id": "RHEA-COMP:10505"}, {"database": "Rhea", "id": "RHEA-COMP:10506"}, {"database": "ChEBI", "id": "CHEBI:57288"}, {"database": "ChEBI", "id": "CHEBI:57384"}, {"database": "ChEBI", "id": "CHEBI:83144"}, {"database": "ChEBI", "id": "CHEBI:83145"}], "ecNumber": "2.1.3.15", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00049152"}]}}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 70, "modifier": "EXACT"}, "end": {"value": 88, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 631, "modifier": "EXACT"}, "end": {"value": 725, "modifier": "EXACT"}}, "description": "CoA carboxyltransferase C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50989"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023160"}], "id": "KW-0275", "category": "Biological process", "name": "Fatty acid biosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022832"}], "id": "KW-0276", "category": "Biological process", "name": "Fatty acid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022516"}], "id": "KW-0444", "category": "Biological process", "name": "Lipid biosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023098"}], "id": "KW-0443", "category": "Biological process", "name": "Lipid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-67NUCHPS7RPVN", "citationType": "submission", "authors": ["Zhang Y.", "Gai S."], "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20331.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR237916", "properties": [{"key": "ProteinId", "value": "WRI20331.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0009317", "properties": [{"key": "GoTerm", "value": "C:acetyl-CoA carboxylase complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003989", "properties": [{"key": "GoTerm", "value": "F:acetyl-CoA carboxylase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016743", "properties": [{"key": "GoTerm", "value": "F:carboxyl- or carbamoyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006633", "properties": [{"key": "GoTerm", "value": "P:fatty acid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.90.226.10", "properties": [{"key": "EntryName", "value": "2-enoyl-CoA Hydratase, Chain A, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001095", "properties": [{"key": "EntryName", "value": "Acetyl_CoA_COase_a_su"}]}, {"database": "InterPro", "id": "IPR029045", "properties": [{"key": "EntryName", "value": "ClpP/crotonase-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR011763", "properties": [{"key": "EntryName", "value": "COA_CT_C"}]}, {"database": "InterPro", "id": "IPR040267", "properties": [{"key": "EntryName", "value": "EID1-like"}]}, {"database": "InterPro", "id": "IPR036047", "properties": [{"key": "EntryName", "value": "F-box-like_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR31348", "properties": [{"key": "EntryName", "value": "EID1-LIKE F-BOX PROTEIN 2-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31348:SF4", "properties": [{"key": "EntryName", "value": "PHYTOCHROME A-ASSOCIATED F-BOX PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03255", "properties": [{"key": "EntryName", "value": "ACCA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52096", "properties": [{"key": "EntryName", "value": "ClpP/crotonase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81383", "properties": [{"key": "EntryName", "value": "F-box domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50989", "properties": [{"key": "EntryName", "value": "COA_CT_CTER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDCIHIRSALSINNNINELSTYSKSLSYFIKALVNRDTFAPVDKLEKKSILSGISLLPPPAFAVQRTFRYFFYSVSYFLAMMTGTVLLKLSDDVVLTIFFMLEDDPRNWSRVACVCTKFSSLIRDVCWKNKCYSTIPSVVSDRFPSSDSPPPGGWSALQKLAVCCPGLLHAGVLLENSDFGPDKNFSKSNKIEMNLNQSNEMITEPCSGSSLNVLDTRLVGLIVHDIDVNPLDRQWRIWMELDSPFGRVNLAMFLEFAIDVEIDLIRRFQFFIGSVIGDHTDDPDYPQSSERARFFLRGQSLDSRQYENWVGLAPVYQTLSLVVALFIVGFAEDSTHLHPVNRTVEEQPAKEWFSKPRHNSSSQKHKHRFWRPGMPWFELWREDARSCIIQCEFDDNGLEDKFEELSKINEISALDESSEINEASDFQFKEAMEHDGDDTNYGFEGLFKDDKIPDSMYENWVGLAPVYQTLSLVVALFYENWVGLAPVYQTLSLVVALFIVGFAEDSTHLHPVNRTVEEQPAKEWFSKPRHNSSSQKHKHRFWRPGMPWFELWREDARSCIIQCEFDDNGLEDKFEELSKINEISALDESSEINEASDFQFKEAMEHDGDDTNYGFEGLFKDDKIPDSMFPIVFIIIEERGSGGALTIGCANKILVLENSVYYVANPESCATVLWKSAKAFAKVAEKPKIIAADFWKLQIDDHVLSIIKSFIGITNDGFIADASMVFSKFSNKRHGVLGGSGLTSGIDENLLRACVMENVIYFFWKGGGWDVFARLGRTRFLWLFGRNLSGDR", "length": 793, "molWeight": 90361, "crc64": "A0B6EFCCB730E1B3", "md5": "68DA932CC24F1DDABEAE846174CDC9C9"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1}, "uniParcId": "UPI00388BFAEE"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT8XUE3", "uniProtkbId": "A0AAT8XUE3_9ARCH", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Candidatus Harpocratesius repetitus", "taxonId": 3049170, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8R3Z"}], "lineage": ["Archaea", "Promethearchaeati", "Promethearchaeota", "Promethearchaeia", "Promethearchaeales", "Promethearchaeaceae", "Candidatus Harpocratesius"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8R3Z"}], "value": "HrAgo1"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 218, "modifier": "EXACT"}, "end": {"value": 334, "modifier": "EXACT"}}, "description": "PAZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50821"}]}, {"type": "Domain", "location": {"start": {"value": 499, "modifier": "EXACT"}, "end": {"value": 803, "modifier": "EXACT"}}, "description": "Piwi", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50822"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8R3Z"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}], "references": [{"referenceNumber": 1, "citation": {"id": "38951509", "citationType": "journal article", "authors": ["Bastiaanssen C.", "Bobadilla Ugarte P.", "Kim K.", "Finocchio G.", "Feng Y.", "Anzelon T.A.", "Kostlbacher S.", "Tamarit D.", "Ettema T.J.G.", "Jinek M.", "MacRae I.J.", "Joo C.", "Swarts D.C.", "Wu F."], "citationCrossReferences": [{"database": "PubMed", "id": "38951509"}, {"database": "DOI", "id": "10.1038/s41467-024-49452-1"}], "title": "RNA-guided RNA silencing by an Asgard archaeal Argonaute.", "publicationDate": "2024", "journal": "Nat. Commun.", "firstPage": "5499", "lastPage": "5499", "volume": "15"}, "referencePositions": ["STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS)"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8R3Z"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8R3Z", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "3.40 A"}, {"key": "Chains", "value": "A=1-817"}]}, {"database": "EMDB", "id": "EMD-18878", "properties": [{"key": "Description", "value": "-"}]}, {"database": "SMR", "id": "A0AAT8XUE3", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.170.260.10", "properties": [{"key": "EntryName", "value": "paz domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.10", "properties": [{"key": "EntryName", "value": "Ribonuclease H-like superfamily/Ribonuclease H"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR003100", "properties": [{"key": "EntryName", "value": "PAZ_dom"}]}, {"database": "InterPro", "id": "IPR036085", "properties": [{"key": "EntryName", "value": "PAZ_dom_sf"}]}, {"database": "InterPro", "id": "IPR003165", "properties": [{"key": "EntryName", "value": "Piwi"}]}, {"database": "InterPro", "id": "IPR012337", "properties": [{"key": "EntryName", "value": "RNaseH-like_sf"}]}, {"database": "InterPro", "id": "IPR036397", "properties": [{"key": "EntryName", "value": "RNaseH_sf"}]}, {"database": "PANTHER", "id": "PTHR22891", "properties": [{"key": "EntryName", "value": "EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02170", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02171", "properties": [{"key": "EntryName", "value": "Piwi"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00949", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00950", "properties": [{"key": "EntryName", "value": "Piwi"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF101690", "properties": [{"key": "EntryName", "value": "PAZ domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53098", "properties": [{"key": "EntryName", "value": "Ribonuclease H-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50821", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50822", "properties": [{"key": "EntryName", "value": "PIWI"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSKSQNKGRKSNDAPLASPCCPQKKKIDLEMNLFPVKISNLKISIYSWLIFPKIDNYKVQRNILEIALSEEALYEYIIQKNKIYQKKRHPNIKRVVLFQNKEFQIEINHLETVYLLDNPTLQNEIFGSICQTVGFEQIGHNYYYSAERQSSQLTQSTKESLKRIFPAIEIDGGKYYLKQGLTTAIHSTKKNFSIDQGKNAISNVVELEQTSKLIQKKNLLEIIMDLNRKVKDHHKIENLLIGSRFITHYNNRIYTIHGIAWNKDPTSTFQIRSKLHQNLEITFEEYYKKNYQLKISDLHQPLIIYYPMSSQKSATSSGSQDILYFLPEFCHLFGLSNLDADNFRIRQEITRNTQMSPSDRYRKLKTFVENQDILEFFKVWGLDIDSRMISMSGIKLPSLEIQTQTGVFPINFEQSNWLSLLNRSQVIDAPELKKWMILYPKKSMSLQEARKFSNDFQKIAQQMGMVCRPPQLQGVFDMTKFLAILKKNPSQHHINSIQLILTITPNRNKTCYRKIKQLCYRDLGIANQNVVLKNLRDQKRRMPIIRNLVRQIICKVPNFNTKYGGALWKIKNNSIPDKTLIVGIDVWHGRPGIDKSIAGIVFSTDKGLHYTANYTITPRKGLEFIHNLGKIIITQLQNHYNATRQYFENILIFRDGVGNTQYNKILQEEFKSIQQELTNSSIFSEKHPKIAIILVNKRINRRLFHKNKQGQILNPKPGTFIEDQYIKSEFSNYYLVPHFSRFGTTRPIHISVIYNNTKYVNFQFVEIANILCHLNYNWAGTVRIPASVEYAHKVADFIGSNQITSIAPELLQTQFYL", "length": 817, "molWeight": 95237, "crc64": "ADFF0A6F311A46FF", "md5": "8C2F476284EA675381DB4798A8B5824A"}, "extraAttributes": {"countByFeatureType": {"Domain": 2}, "uniParcId": "UPI0032E93922"}, "cluster_size": 1, "family": "Promethearchaeaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P2T5", "uniProtkbId": "A0AAU7P2T5_CALMC", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Callistoctopus minor", "commonName": "Octopus", "synonyms": ["Octopus minor"], "taxonId": 515824, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35919.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Cephalopoda", "Coleoidea", "Octopodiformes", "Octopoda", "Incirrata", "Octopodidae", "Callistoctopus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35919.1"}], "value": "Tryptophan decarboxylase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35919.1"}], "value": "TDC"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "pyridoxal 5'-phosphate", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001933"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000382"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:597326"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009533"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000382"}], "value": "Belongs to the group II decarboxylase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 290, "modifier": "EXACT"}, "end": {"value": 333, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 299, "modifier": "EXACT"}, "end": {"value": 333, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022793"}], "id": "KW-0210", "category": "Molecular function", "name": "Decarboxylase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023239"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000382"}], "id": "KW-0456", "category": "Molecular function", "name": "Lyase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022898"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000382"}], "id": "KW-0663", "category": "Ligand", "name": "Pyridoxal phosphate"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B1PARK2TANKH3", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35919.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP889620", "properties": [{"key": "ProteinId", "value": "XBS35919.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016831", "properties": [{"key": "GoTerm", "value": "F:carboxy-lyase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0030170", "properties": [{"key": "GoTerm", "value": "F:pyridoxal phosphate binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006520", "properties": [{"key": "GoTerm", "value": "P:amino acid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0019752", "properties": [{"key": "GoTerm", "value": "P:carboxylic acid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.90.1150.10:FF:000018", "properties": [{"key": "EntryName", "value": "Histidine decarboxylase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.90.1150.10", "properties": [{"key": "EntryName", "value": "Aspartate Aminotransferase, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1340.10", "properties": [{"key": "EntryName", "value": "dopa decarboxylase, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.640.10", "properties": [{"key": "EntryName", "value": "Type I PLP-dependent aspartate aminotransferase-like (Major domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR010977", "properties": [{"key": "EntryName", "value": "Aromatic_deC"}]}, {"database": "InterPro", "id": "IPR002129", "properties": [{"key": "EntryName", "value": "PyrdxlP-dep_de-COase"}]}, {"database": "InterPro", "id": "IPR015424", "properties": [{"key": "EntryName", "value": "PyrdxlP-dep_Trfase"}]}, {"database": "InterPro", "id": "IPR015421", "properties": [{"key": "EntryName", "value": "PyrdxlP-dep_Trfase_major"}]}, {"database": "InterPro", "id": "IPR015422", "properties": [{"key": "EntryName", "value": "PyrdxlP-dep_Trfase_small"}]}, {"database": "PANTHER", "id": "PTHR11999", "properties": [{"key": "EntryName", "value": "GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11999:SF70", "properties": [{"key": "EntryName", "value": "MIP05841P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00282", "properties": [{"key": "EntryName", "value": "Pyridoxal_deC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00800", "properties": [{"key": "EntryName", "value": "YHDCRBOXLASE"}]}, {"database": "SUPFAM", "id": "SSF53383", "properties": [{"key": "EntryName", "value": "PLP-dependent transferases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDSCEFRKRGKEMVDYIADYMETLSVRKVTAQVEPGKMIGLPKDFLHESGKGGGVIQVCATLGTTAVCSFDALHEIAEFAHSINFNPNKWMLHWGIPLSRRFRSLKLWFVLRTYGIEGLQHYIREHVRLAKLFESKVLEEDRFEVLGQVIMGLVCFRLKGPNTLTQKLLRQINESGRLHMVPALLNEHYIIRFAICAQNADDSDIIYAWQTISKIADELLASRERESSVRESRRIALSDTSEEGESAEEEEVFLEFDKENIYDNQQLNFQRARMRRNLFLRMVSDPKSYSPHMMKSYSIDDSSSRLPSDTPSETGSTNSTKRSPKTPQLATPL", "length": 333, "molWeight": 38191, "crc64": "CB98A83C769E46F7", "md5": "73D7356F8F437A0A70C5AEB17F0B9926"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D2D600"}, "cluster_size": 1, "family": "Octopodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BI08", "uniProtkbId": "A0AAQ5BI08_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519691.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519691.1"}], "value": "Serine/threonine kinase 17b"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519691.1"}], "value": "STK17B"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BI08"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BI08"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519691.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519691.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15815621", "citationType": "journal article", "authors": ["Hillier L.W.", "Graves T.A.", "Fulton R.S.", "Fulton L.A.", "Pepin K.H.", "Minx P.", "Wagner-McPherson C.", "Layman D.", "Wylie K.", "Sekhon M.", "Becker M.C.", "Fewell G.A.", "Delehaunty K.D.", "Miner T.L.", "Nash W.E.", "Kremitzki C.", "Oddy L.", "Du H.", "Sun H.", "Bradshaw-Cordum H.", "Ali J.", "Carter J.", "Cordes M.", "Harris A.", "Isak A.", "van Brunt A.", "Nguyen C.", "Du F.", "Courtney L.", "Kalicki J.", "Ozersky P.", "Abbott S.", "Armstrong J.", "Belter E.A.", "Caruso L.", "Cedroni M.", "Cotton M.", "Davidson T.", "Desai A.", "Elliott G.", "Erb T.", "Fronick C.", "Gaige T.", "Haakenson W.", "Haglund K.", "Holmes A.", "Harkins R.", "Kim K.", "Kruchowski S.S.", "Strong C.M.", "Grewal N.", "Goyea E.", "Hou S.", "Levy A.", "Martinka S.", "Mead K.", "McLellan M.D.", "Meyer R.", "Randall-Maher J.", "Tomlinson C.", "Dauphin-Kohlberg S.", "Kozlowicz-Reilly A.", "Shah N.", "Swearengen-Shahid S.", "Snider J.", "Strong J.T.", "Thompson J.", "Yoakum M.", "Leonard S.", "Pearman C.", "Trani L.", "Radionenko M.", "Waligorski J.E.", "Wang C.", "Rock S.M.", "Tin-Wollam A.M.", "Maupin R.", "Latreille P.", "Wendl M.C.", "Yang S.P.", "Pohl C.", "Wallis J.W.", "Spieth J.", "Bieri T.A.", "Berkowicz N.", "Nelson J.O.", "Osborne J.", "Ding L.", "Meyer R.", "Sabo A.", "Shotland Y.", "Sinha P.", "Wohldmann P.E.", "Cook L.L.", "Hickenbotham M.T.", "Eldred J.", "Williams D.", "Jones T.A.", "She X.", "Ciccarelli F.D.", "Izaurralde E.", "Taylor J.", "Schmutz J.", "Myers R.M.", "Cox D.R.", "Huang X.", "McPherson J.D.", "Mardis E.R.", "Clifton S.W.", "Warren W.C.", "Chinwalla A.T.", "Eddy S.R.", "Marra M.A.", "Ovcharenko I.", "Furey T.S.", "Miller W.", "Eichler E.E.", "Bork P.", "Suyama M.", "Torrents D.", "Waterston R.H.", "Wilson R.K."], "citationCrossReferences": [{"database": "PubMed", "id": "15815621"}, {"database": "DOI", "id": "10.1038/nature03466"}], "title": "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.", "publicationDate": "2005", "journal": "Nature", "firstPage": "724", "lastPage": "731", "volume": "434"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519691.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519691.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC114760", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000714422.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519691.1"}, {"key": "GeneId", "value": "ENSG00000081320.12"}]}, {"database": "HGNC", "id": "HGNC:11396", "properties": [{"key": "GeneName", "value": "STK17B"}]}, {"database": "OpenTargets", "id": "ENSG00000081320", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000154014", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 2"}]}], "sequence": {"value": "MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGSFLYLTLNHRISALERLQWSVVLLIQCLYAAQQSFL", "length": 76, "molWeight": 8900, "crc64": "781307B56D56DA7F", "md5": "61A71172467296839143D82E8B055E97"}, "extraAttributes": {"uniParcId": "UPI0032CF7F5F"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU68", "uniProtkbId": "A0AAT9UU68_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41674.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41674.1"}], "value": "Cytochrome P450 3638C1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41674.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117234", "properties": [{"key": "ProteinId", "value": "WIM41674.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTIASVNERFLRVMKMPINCNILYRIISKMKFELCYAILLFYILTIKWRMQKKTSMLRSFNRAPSPSIIESVCLLRGNMKDCAAKQLKLLKEYKPPFVIWLFRTPMIVIGDKHDVQTVLKTTQESNTRRFFGGILNNNASISQNEIYHKVCQTIVSAFTPAMMQRYFPLLNQYSERLASKLEPHCDTAEAFNIGNYISSVTLDIITQNMTGYKLSSLENKNTKFFDAFFKLLKMETMRCTFPSPFPPVMFNTYLYLSGNLDKYEEIHRLSRKIVQNRLRELSKRGRDHHYENAYETVEGPETLLDLLLQLKDDKHFTEKHIRVEVLNMIMMGYKSTFLTISSVLLMLAANLDAQEKVYEEIRTILGDDERKVQMEDIKDLVYMEQCINETLRKFPIIPTATRRHNKDIELNDKKIIPAGCQILVNFHSIHHDKRIFPNSDEWDPKHFAPNNISRIQRQIYPYGADPRSEISAEYAMISVKIQLIHLLRRYRLSTSMKKRNIHFVLDLGLRNSSGYWLKLSSRSKNNPKHL", "length": 530, "molWeight": 62155, "crc64": "582C086640400F89", "md5": "15F441FEBBB06ED1FD82036A253B9DAA"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "uniParcId": "UPI0035D31D00"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEP2", "uniProtkbId": "A0AB38ZEP2_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02725.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02725.1"}], "value": "Venom cystatin 4"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 119, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044327571"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02725.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517475", "properties": [{"key": "ProteinId", "value": "WXI02725.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004869", "properties": [{"key": "GoTerm", "value": "F:cysteine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00042", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.450.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000010", "properties": [{"key": "EntryName", "value": "Cystatin_dom"}]}, {"database": "InterPro", "id": "IPR046350", "properties": [{"key": "EntryName", "value": "Cystatin_sf"}]}, {"database": "SUPFAM", "id": "SSF54403", "properties": [{"key": "EntryName", "value": "Cystatin/monellin"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIKSISIILILAGVCLVEFSSAGFFSSQGKRGPCPGCQNEISKNDEMMRKSLQLVLSKQNAALRNIKVISATKQTVVGYKYRINFEADAPGGRKTCDTTFVVSAGVEPKLKSVDRFECN", "length": 119, "molWeight": 12980, "crc64": "8A839F83FF4B597C", "md5": "4F9C9A601086F987CA7F49EF07D997FE"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BF044"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0MUF1", "uniProtkbId": "A0AAU0MUF1_UREUN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Urechis unicinctus", "commonName": "Fat innkeeper worm", "synonyms": ["Chinese penis fish"], "taxonId": 6432, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59941.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Echiura", "Xenopneusta", "Urechidae", "Urechis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59941.1"}], "value": "Heat shock protein family A member 12 variant X2"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59941.1"}], "value": "HSPA12"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007381"}], "value": "Belongs to the heat shock protein 70 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59941.1"}], "id": "KW-0346", "category": "Biological process", "name": "Stress response"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FQL9M4QGPVUS3", "citationType": "submission", "authors": ["Liu D.D."], "publicationDate": "FEB-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59941.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OM803162", "properties": [{"key": "ProteinId", "value": "WOS59941.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0140662", "properties": [{"key": "GoTerm", "value": "F:ATP-dependent protein folding chaperone"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd10229", "properties": [{"key": "EntryName", "value": "ASKHA_NBD_HSP70_HSPA12"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.90.640.10", "properties": [{"key": "EntryName", "value": "Actin, Chain A, domain 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR043129", "properties": [{"key": "EntryName", "value": "ATPase_NBD"}]}, {"database": "InterPro", "id": "IPR013126", "properties": [{"key": "EntryName", "value": "Hsp_70_fam"}]}, {"database": "PANTHER", "id": "PTHR14187", "properties": [{"key": "EntryName", "value": "ALPHA KINASE/ELONGATION FACTOR 2 KINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14187:SF5", "properties": [{"key": "EntryName", "value": "HEAT SHOCK 70 KDA PROTEIN 12A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00012", "properties": [{"key": "EntryName", "value": "HSP70"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53067", "properties": [{"key": "EntryName", "value": "Actin-like ATPase domain"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MAKTDAADELVRLLNALHAHNKGMEEAKAAAAISEPPKDYIMVGAIDFGTTFSGYAFSFKSQKDDIRMFTDWGSGVGLSGCKAPTCVLTNAKGDFEAFGYEAEQKYANLDETEVKKYCFYDRFKMRLHTEKNLGRSTQIKARNGKNRSALEVFSMALRYLKSHLIDAVEKQSSHPISRDHIRWVITVPAIWSDASKQFMREAAFLAGIIKDVESTRLLIALEPEAASLYCRTLDIEHLVTGSYTASVKMAAGVKYLVLDAGGGTLDVTAHQLLGDASGRVRELYQASGGNLGGTQVDKHYVELLEKIFGKDVLDRYRKECAAGWLQFMCTFERIKRSVKTSGTTTTNIPIPFELGETYVEIKGKPLRRGIQDYQKINPGVRFNAGMLCLSNDVMVKLFTPVVKGIVDHMKTLMALSVMEGVTHLMMVGGFSDSPVLQDAIKDALGTRLNIIIPHDASLCVIKGAAIFGHDPSLISTRIARKTYGIEVTQEFDTDIHDINKKEVVDGVPHCMEIFKVLVQKGEEVEIGNTRLFNFTPLRANQTGADIKIYSSDQKSPKYVKENGVSYHGNIHINLSGLGINRLILITVMFGGTEIHVHAKDGSCGADGHFATTRVQFMTE", "length": 619, "molWeight": 68360, "crc64": "250396A344685B8A", "md5": "7A41193341124C64387C3CDC0652B492"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0035D34CE4"}, "cluster_size": 2, "family": "Urechidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MLR5", "uniProtkbId": "A0AA96MLR5_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50037.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR000988"}], "value": "Deoxyribonuclease"}}}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007359"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR000988"}], "value": "Belongs to the DNase I family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 309, "modifier": "EXACT"}}, "description": "Deoxyribonuclease", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041680428"}, {"type": "Domain", "location": {"start": {"value": 49, "modifier": "EXACT"}, "end": {"value": 274, "modifier": "EXACT"}}, "description": "Endonuclease/exonuclease/phosphatase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03372"}]}, {"type": "Active site", "location": {"start": {"value": 103, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000988-1"}]}, {"type": "Active site", "location": {"start": {"value": 158, "modifier": "EXACT"}, "end": {"value": 158, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000988-1"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 199, "modifier": "EXACT"}, "end": {"value": 233, "modifier": "EXACT"}}, "description": "Essential for enzymatic activity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000988-2"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000988-2"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR000988"}], "id": "KW-0255", "category": "Molecular function", "name": "Endonuclease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR000988"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022722"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR000988"}], "id": "KW-0540", "category": "Molecular function", "name": "Nuclease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50037.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460114", "properties": [{"key": "ProteinId", "value": "WNS50037.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004530", "properties": [{"key": "GoTerm", "value": "F:deoxyribonuclease I activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006308", "properties": [{"key": "GoTerm", "value": "P:DNA catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.60.10.10", "properties": [{"key": "EntryName", "value": "Endonuclease/exonuclease/phosphatase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR016202", "properties": [{"key": "EntryName", "value": "DNase_I"}]}, {"database": "InterPro", "id": "IPR036691", "properties": [{"key": "EntryName", "value": "Endo/exonu/phosph_ase_sf"}]}, {"database": "InterPro", "id": "IPR005135", "properties": [{"key": "EntryName", "value": "Endo/exonuclease/phosphatase"}]}, {"database": "PANTHER", "id": "PTHR11371", "properties": [{"key": "EntryName", "value": "DEOXYRIBONUCLEASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11371:SF31", "properties": [{"key": "EntryName", "value": "EXTRACELLULAR NUCLEASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03372", "properties": [{"key": "EntryName", "value": "Exo_endo_phos"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF000988", "properties": [{"key": "EntryName", "value": "DNase_I_euk"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00130", "properties": [{"key": "EntryName", "value": "DNASEI"}]}, {"database": "SMART", "id": "SM00476", "properties": [{"key": "EntryName", "value": "DNaseIc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56219", "properties": [{"key": "EntryName", "value": "DNase I-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRLLSVLAAAAVLLAFCSLSRSKSIKVAAFNIQIFGQSKYRKPGVVPILVKIVRRYDLVFIQEIRDKSETVIFNFVRAVNSAEGRAAFAVHVSRRLGRTSSKEQYAYMYRTDAIRIDAVSVANGFINNFERPPYVALVTVLNQNRGCSSFSFLAIGAHIKPGRVHVVNELNSMVKVYEAAQRHFRMDRALLMGDFNAGCGYLSKTNYRHLKLTTDRRFKWLINQDSTVAKSWCAYDRFVAAGGLEEYVSGRPSVYYFNTTMGLSRQQAKKVSDHFPIELVLDDSLRNRKRSRPAVGNAGVTVAEGYAII", "length": 309, "molWeight": 34739, "crc64": "9628A691582F0605", "md5": "D8DBB1DA0F806D17FE6A0371B11EDD0A"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Active site": 2, "Disulfide bond": 1}, "uniParcId": "UPI002B28DCB9"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN60", "uniProtkbId": "A0AA96MN60_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50085.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50085.1"}], "value": "Uncharacterized protein 20"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 440, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041678660"}, {"type": "Region", "location": {"start": {"value": 45, "modifier": "EXACT"}, "end": {"value": 131, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 45, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 78, "modifier": "EXACT"}, "end": {"value": 87, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50085.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460162", "properties": [{"key": "ProteinId", "value": "WNS50085.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005592", "properties": [{"key": "GoTerm", "value": "C:collagen type XI trimer"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030020", "properties": [{"key": "GoTerm", "value": "F:extracellular matrix structural constituent conferring tensile strength"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030198", "properties": [{"key": "GoTerm", "value": "P:extracellular matrix organization"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR008160", "properties": [{"key": "EntryName", "value": "Collagen"}]}, {"database": "InterPro", "id": "IPR050149", "properties": [{"key": "EntryName", "value": "Collagen_superfamily"}]}, {"database": "PANTHER", "id": "PTHR24023", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24023:SF42", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA-1(XI) CHAIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01391", "properties": [{"key": "EntryName", "value": "Collagen"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MNTALAIVGIVIGVVAFAAAQDDLQCIENPTGEVSLNVAVRGIPGQQGPQGIKGDIGSRGQKGQNGDIGVQGTEGKQGVVGPGGPVGAKGEVGQQGVRGMKGSSGPIGPKGIVGSHGRQGDIGATGPRGNPGRAGFPGPKGLLGSPGDLLDSAQIQSLTETVVSSTAPKIQATVMQSITEVEAKVKVLNQALREEVMIELQALKDSIGSLEIVESKKCGIVGPWRRVAHFDTTNNDTCPPVLQTVLNPTTGQKACGRRASTLGCDLWQVPSKGLYTSVCGKARGYQSGNTLAFFPYHFPTYNQKTLNSSYVNGISITSGNLGRHIWTFAVGRTELVTGTSADAMCPCALNPPQTSPPPFIGDNYYCESGLRNRIVFRTAWEDVLWDGQGCFTAGNTCCARSGWFHRQLSPSSDGIQVRWCGYAGAATTDIPTDLVEIWVM", "length": 440, "molWeight": 46100, "crc64": "1DB803375FF6DABE", "md5": "A724D131CC789576800BB0C7BAB54C43"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1, "Compositional bias": 2}, "uniParcId": "UPI002B280104"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39J761", "uniProtkbId": "A0AB39J761_STIJA", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Stichopus japonicus", "commonName": "Sea cucumber", "taxonId": 307972, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88988.1"}], "lineage": ["Eukaryota", "Metazoa", "Echinodermata", "Eleutherozoa", "Echinozoa", "Holothuroidea", "Aspidochirotacea", "Aspidochirotida", "Stichopodidae", "Apostichopus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88988.1"}], "value": "Guanylate binding protein 3"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 301, "modifier": "EXACT"}}, "description": "Guanylate-binding protein N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02263"}]}, {"type": "Coiled coil", "location": {"start": {"value": 716, "modifier": "EXACT"}, "end": {"value": 743, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9KB24OKSBOGJC", "citationType": "submission", "authors": ["Yang L.", "Li C."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88988.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ120689", "properties": [{"key": "ProteinId", "value": "XDN88988.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003924", "properties": [{"key": "GoTerm", "value": "F:GTPase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036543", "properties": [{"key": "EntryName", "value": "Guanylate-bd_C_sf"}]}, {"database": "InterPro", "id": "IPR015894", "properties": [{"key": "EntryName", "value": "Guanylate-bd_N"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "PANTHER", "id": "PTHR10751", "properties": [{"key": "EntryName", "value": "GUANYLATE BINDING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02263", "properties": [{"key": "EntryName", "value": "GBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48340", "properties": [{"key": "EntryName", "value": "Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAVDKAVPLCLPDNQTWDAEEQCIHINEGAPRNKLQLCEEGLNIIKSIDHSTVVVCITGPVRSGKSFLLSQIQNGGRFDVHHGTTSKTTGIWIASPECTVMRNGHPARLIFLDTEGLGSLNTSDGNEDNTWERKLLALSLLLSSYFIFNSQGTPSYDDLLKLGFLASFSEFVKKAKMPQRRGRHTTHQSNTSLPDFLWLIRDAILQPELKNKPCTWSNYIKETILQNRNASSPDQRNQIRKSMIDTFGEIDAESLPFPSIDRVVIQTLDSPEGISNLNPTFNDALQHITTKINESANVKKEVGKVLKGRDLADLLQAYVNVLNTPNGIIDVESAWDCLTAAKEAERLYANEMRAIQMPCEEEQVDACHLIATDKTLTLISSKTGKCSASDIEFYTAKFNAQIKEKLRSCHVKNEELPRSMCKKIKKKMKTKYLQQTNVADLKDVKKARQGALQEYQKSARGPAKMVMLNELESLVSEFEERAGNILSEKFFDQAVSLYRDEIRKLKLPCSNRQLNKLHRSACSKAESFYTNMIGNDGNRLISDRRSQLLTEIENEKSIIADNNSRLSQESCDDLMRSLRNEHLKPIIDNLGTGSNIQDLKDGFERVLNHYDRGAVGPRSQYVRKTAVEDVETLIKESQRTLIQRGMHKAKEFYTQQLYNLPLPCSEEYLYRTDRTCLGPAKERFKFYCTGCPSEVCEKSLQTLTWELKGIFDTRKFEIHAISKEDLRKQIERLERDYRLDDTLQNSSQRNEDNVKIIHSQILREFKQSARGVGVDEFYEETKSRYQQTQAQRRKEDKVRNDLLWAGGALAFSMLAYGVSKFFETSDDDKERKTSRRSSPRKY", "length": 842, "molWeight": 96121, "crc64": "4819CD9A902EA4A1", "md5": "675871B62C9FA4D481790B0E7C6D463E"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Coiled coil": 1}, "uniParcId": "UPI00388BF9F2"}, "cluster_size": 3, "family": "Stichopodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6SHC0", "uniProtkbId": "A0AAU6SHC0_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32414.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32414.1"}], "value": "Circadian clock-controlled protein"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00060902"}], "value": "Belongs to the TO family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 255, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043357942"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023108"}], "id": "KW-0090", "category": "Biological process", "name": "Biological rhythms"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B0NSJ4HC5RLL1", "citationType": "submission", "authors": ["S S.B.", "Negi N.", "Nagarjuna Reddy K.", "R G.G."], "title": "Takout-proteins of Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32414.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR247757", "properties": [{"key": "ProteinId", "value": "WZP32414.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007623", "properties": [{"key": "GoTerm", "value": "P:circadian rhythm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "3.15.10.30:FF:000001", "properties": [{"key": "EntryName", "value": "Takeout-like protein 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.15.10.30", "properties": [{"key": "EntryName", "value": "Haemolymph juvenile hormone binding protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR010562", "properties": [{"key": "EntryName", "value": "Haemolymph_juvenile_hormone-bd"}]}, {"database": "InterPro", "id": "IPR038606", "properties": [{"key": "EntryName", "value": "To_sf"}]}, {"database": "PANTHER", "id": "PTHR11008:SF39", "properties": [{"key": "EntryName", "value": "CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11008", "properties": [{"key": "EntryName", "value": "PROTEIN TAKEOUT-LIKE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF06585", "properties": [{"key": "EntryName", "value": "JHBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00700", "properties": [{"key": "EntryName", "value": "JHBP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MCTQYFSSRSFILLFCVILGLSLAQCKRSSKIPDDIHLCKKDDPELNKCLEELFESVRPKLSQGIPEIGLPPMDPLILKEVVIFRGGTGQNMRAVGHDIKITGISNLKINYIKADVENLEISVGVHFPYLRYEGQYDVNARFVNIPVKGKGPMRGNATEVDAQAILKGKFVEVNGEKFVEFTSATVDVDVKDYSVRVEKLFPDKQLNDAINVLINDRKMQSMATAKPIVNKVAGSMMLEMVNRIAKNLSFDEVFA", "length": 255, "molWeight": 28518, "crc64": "C628C73D4D28DAB8", "md5": "35E830360D0C3FD16CBA6E4C963831FE"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D37594"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PAU8", "uniProtkbId": "A0AAU6PAU8_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20564.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20564.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 30, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 31, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043548658"}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20564.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20564.1"}], "value": "U_LCTX_83_Cm32", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20564.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480833", "properties": [{"key": "ProteinId", "value": "WXB20564.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR023795", "properties": [{"key": "EntryName", "value": "Serpin_CS"}]}, {"database": "PROSITE", "id": "PS00284", "properties": [{"key": "EntryName", "value": "SERPIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "FKTIVCGRQNMGRKMLVLLCLIAVAISSMGQNLPPSQLKADHPFVFLIREEVKVPLVGNYSQI", "length": 63, "molWeight": 7013, "crc64": "F73B5762D82F0009", "md5": "B3AB277E94146753744FA51F234C168D"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D30E0A"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96Q3L1", "uniProtkbId": "A0AA96Q3L1_9HEMI", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Empoasca flavescens", "taxonId": 317765, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNV59769.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Auchenorrhyncha", "Membracoidea", "Cicadellidae", "Typhlocybinae", "Empoascini", "Empoasca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNV59769.1"}], "value": "Mucin-like protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNV59769.1"}], "value": "MLP2"}}], "features": [{"type": "Region", "location": {"start": {"value": 213, "modifier": "EXACT"}, "end": {"value": 472, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1417, "modifier": "EXACT"}, "end": {"value": 1439, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 219, "modifier": "EXACT"}, "end": {"value": 264, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 283, "modifier": "EXACT"}, "end": {"value": 293, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 306, "modifier": "EXACT"}, "end": {"value": 333, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 353, "modifier": "EXACT"}, "end": {"value": 403, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 425, "modifier": "EXACT"}, "end": {"value": 434, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1427, "modifier": "EXACT"}, "end": {"value": 1439, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DTH9FOVLRRL4M", "citationType": "submission", "authors": ["Pan C.", "He X."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNV59769.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR504429", "properties": [{"key": "ProteinId", "value": "WNV59769.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0098592", "properties": [{"key": "GoTerm", "value": "C:cytoplasmic side of apical plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0035332", "properties": [{"key": "GoTerm", "value": "P:positive regulation of hippo signaling"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR047145", "properties": [{"key": "EntryName", "value": "FRMD6-like"}]}, {"database": "PANTHER", "id": "PTHR13429", "properties": [{"key": "EntryName", "value": "FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13429:SF5", "properties": [{"key": "EntryName", "value": "PROTEIN EXPANDED"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNLIQVNQVLQQQQPQSLKIPLPQVKLLNLQRQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVLQQQQPQSLKIPLPQVKLLNLQRQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVHQQQQPQSLKILQPQVKLLNLQQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQPSTTTTTESEDSTTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESVSTESSTSTTTMETEDSTTTRDTTESSTMTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESDSSESSTSTTTTTESEDSTTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSKESTTTVSAKMFLSSEESDEYDEIESSSSSGESSEEESSNENSVLVVERESTSSLESEEQTAEESIEELCKRVYAQKGTESDIDYKKRVYTRRETESDEEYVERINTIRIIFSESSIWQEDESLTYSEDYYKCASKQKDNEDTKTYYTRLTKRLDGESDQSYVQRLSGIQRVEPNLALWSEETYLYLTKTYYLIRYTRTVTEETHTYYLRLFRQETRETIENYVKRIKIISTLFSELTIWENLEEIEITRTYYEYLFKQNSGESSDKYYNRIMYQGLFESPEHYVNRISFIQKLFPGLDLWTNKKYLIYTAKYFKLLYKRSTEESDEQYYERILHRRSDESSDDYVKRISIIETLFKNLSFLFNNAGYLRYTREYYDILYGQRNKETDQKYLARVFKQGAKEGNVEFIERMKLLNAMYPNLAIWHNPKEVRYTRRYYLDLYKRNRGESEDDYYRRLMYQGLFETDEHYTQRMQVVQAILPKLDLWTEPKYLPYTAKYYRFLYQQKDGESETAFLKNIFKRKSQESQENFVKRLDLLKRVLHVELESIFDNLEALEWTKEYYTINYGQKQGESMEDFVARTFKHDEDESDSEYVTRIKIVMALFPELEVWNDKEQLECTKHFYELLYEQQPDQSEQDYYQKIFGLGKNESPEDYFKRIQIFQLIHPESQIWDNPDYLIYTKKFYEIQYTKPKDTKEEDFIKSIFQRAASETKTHYLNRLTTFLLVDSKNPIWSDSKYLKYTKPYINVLYAQKPDESVSSWANRILKQYPEENEEEYASRLKIIQAALSEPIWKKVTAAKSGTEKIVSHTGVTYINDEKEDSSEDDETLAERVLAKRHYESYHSYLARILERDSDEDDDNYKQRLEWIKKKFPTVALSEQFQEAYKGVFKSQEKHPLLAAYRRKAVTQLEKEVEAVKHIPLLSKRSRVILTSQHPWESRRQYNERLYKQKDEEEEEDYLTRLLARKPHESNKHYIKRLVTLRKVFPTLDVWEDNAYTNYVSDIEQDDVDNYQSNKHQDKSTSSLSSDSSISD", "length": 1439, "molWeight": 169253, "crc64": "A41BB495E9FFE06F", "md5": "EAEAB5B9748C7BAF7DF8798CB32BEFF9"}, "extraAttributes": {"countByFeatureType": {"Region": 2, "Compositional bias": 6}, "uniParcId": "UPI002B31B8EE"}, "cluster_size": 1, "family": "Cicadellidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P9WEJ8", "uniProtkbId": "PTHA_PENTH", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Penicillium thymicola", "taxonId": 293382, "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Pezizomycotina", "Eurotiomycetes", "Eurotiomycetidae", "Eurotiales", "Aspergillaceae", "Penicillium"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36702957"}], "value": "Arginine-containing cyclodipeptide synthase pthA"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36702957"}], "value": "RCDPS pthA"}], "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}], "value": "6.3.2.-"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36702957"}], "value": "pthA"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}, {"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "36702957"}], "value": "Arginine-containing cyclodipeptide synthase; part of the cluster that mediates the biosynthesis of a highly modified cyclo-arginine-aspartate dipeptide (cRD) (PubMed:36702957). Within the pathway, pthA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Asp diketopiperazine (cRW) from L-arginyl-tRNA(Arg) + L-aspartyl-tRNA(Asp) (PubMed:36702957). Additional enzymes from the cluster then further modify the cyclo-Arg-Asp diketopiperazine (cRW) scaffold (Probable)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "L-aspartyl-tRNA(Asp) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-aspartyl) + tRNA(Asp) + tRNA(Arg) + 2 H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:80415"}, {"database": "Rhea", "id": "RHEA-COMP:9658"}, {"database": "Rhea", "id": "RHEA-COMP:9660"}, {"database": "Rhea", "id": "RHEA-COMP:9673"}, {"database": "Rhea", "id": "RHEA-COMP:9678"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:78442"}, {"database": "ChEBI", "id": "CHEBI:78513"}, {"database": "ChEBI", "id": "CHEBI:78516"}, {"database": "ChEBI", "id": "CHEBI:231489"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:80416"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}]}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}], "value": "Secondary metabolite biosynthesis"}], "commentType": "PATHWAY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P9WEJ7"}], "value": "The conserved DDXXE motif is essential for catalytic activity"}], "commentType": "DOMAIN"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the arginine-containing cyclodipeptide synthase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 530, "modifier": "EXACT"}}, "description": "Arginine-containing cyclodipeptide synthase pthA", "featureId": "PRO_0000461003"}, {"type": "Motif", "location": {"start": {"value": 419, "modifier": "EXACT"}, "end": {"value": 423, "modifier": "EXACT"}}, "description": "Conserved DDXXE motif", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P9WEJ7"}]}], "keywords": [{"id": "KW-0436", "category": "Molecular function", "name": "Ligase"}], "references": [{"referenceNumber": 1, "citation": {"id": "36702957", "citationType": "journal article", "authors": ["Yee D.A.", "Niwa K.", "Perlatti B.", "Chen M.", "Li Y.", "Tang Y."], "citationCrossReferences": [{"database": "PubMed", "id": "36702957"}, {"database": "DOI", "id": "10.1038/s41589-022-01246-6"}], "title": "Genome mining for unknown-unknown natural products.", "publicationDate": "2023", "journal": "Nat. Chem. Biol.", "firstPage": "633", "lastPage": "640", "volume": "19"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "FUNCTION", "CATALYTIC ACTIVITY", "PATHWAY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP622862", "properties": [{"key": "ProteinId", "value": "WCB22921.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016874", "properties": [{"key": "GoTerm", "value": "F:ligase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MSTLYLLANLRNRPDGRHSIDFGSLSARESDPVKMPHEITGLFSSDYCSSTSTTLEAEESEAYSKALSRNKRAAGILEHFLNGEQAAAHPSVCLQDRARLRLCEEAILVGAPRGTATRAREGIASYDKMEFLFPGSRQRKSIQMLHVSCPSLQPGATLLDSHSGSVHDSITILSGMCLFTRKILNSTTTNGRLDGQKLRHMPPTLYEMECIARLSAIIADVTTLTQSNFGEDNHPAVNIVLDLPSWHYYQFIEDCIKSDTCSLEEAIDWTEAIKLRRQQLASVLKKAVWHELGQRQVAHKSTLKAIQISPESTVVDELIKETLQRGHQPRLDDILHALSGTPHSLWPQFYSLLRDRDKPHSIRDLGFLFYVFQVVRPALLKAIPCQEAPSSKAPACEQPNLHRGQRQCLPQRPLIISLDDRAERKIYSQAHSLLLRLSRSSNQLVNPTLVQLYMPRRVYIDGNKDGQRLYWHDPSPVLPLLEGTKEQQRRDARNHDHHRRELQQTDILTELYGRDCSANIQGWFKEAGLC", "length": 530, "molWeight": 59930, "crc64": "BA404350F7281C87", "md5": "41828ABAF62CCED7FA3961C2BA0A99E3"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 1, "PATHWAY": 1, "DOMAIN": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Motif": 1}, "uniParcId": "UPI00279CF3D5"}, "cluster_size": 2, "family": "Aspergillaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P7K2", "uniProtkbId": "A0AAF0P7K2_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Aparapotamon grahami", "taxonId": 511395, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Aparapotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}], "value": "Cation-independent mannose-6-phosphate receptor-like protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}], "value": "scaffold2047706"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004608"}], "value": "Endosome membrane", "id": "SL-0100"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004394"}], "value": "Golgi apparatus membrane", "id": "SL-0134"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00038191"}], "value": "Belongs to the MRL1/IGF2R family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 7, "modifier": "EXACT"}, "end": {"value": 138, "modifier": "EXACT"}}, "description": "MRH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51914"}]}, {"type": "Region", "location": {"start": {"value": 151, "modifier": "EXACT"}, "end": {"value": 173, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 151, "modifier": "EXACT"}, "end": {"value": 162, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 188, "modifier": "EXACT"}, "end": {"value": 188, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022753"}], "id": "KW-0967", "category": "Cellular component", "name": "Endosome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023034"}], "id": "KW-0333", "category": "Cellular component", "name": "Golgi apparatus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}], "value": "F81101C", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}], "value": "F81101C", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59242.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515365", "properties": [{"key": "ProteinId", "value": "WMS59242.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0010008", "properties": [{"key": "GoTerm", "value": "C:endosome membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000139", "properties": [{"key": "GoTerm", "value": "C:Golgi membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005802", "properties": [{"key": "GoTerm", "value": "C:trans-Golgi network"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.70.130.10", "properties": [{"key": "EntryName", "value": "Mannose-6-phosphate receptor binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009011", "properties": [{"key": "EntryName", "value": "Man6P_isomerase_rcpt-bd_dom_sf"}]}, {"database": "InterPro", "id": "IPR044865", "properties": [{"key": "EntryName", "value": "MRH_dom"}]}, {"database": "PANTHER", "id": "PTHR15071:SF0", "properties": [{"key": "EntryName", "value": "MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR15071", "properties": [{"key": "EntryName", "value": "MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50911", "properties": [{"key": "EntryName", "value": "Mannose 6-phosphate receptor domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51914", "properties": [{"key": "EntryName", "value": "MRH"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "KVEDSGLQCHIRFDDAKANIDLKPLHRPEGYQVNFGNKTFTVNICGSACNNTSGSCTSDGDSYGLSKKSELQWNYGQLSLTYYGGSHCNESLSGHKTTTIHFECDMNVGFGFPVADELMESLDCHAIFTWKTNVTCIEGIYATEDTPPLNISSANNTAGQNDPSKDSLKSKTSTHATASTVIATVMVV", "length": 188, "molWeight": 20332, "crc64": "6431770EFC45C177", "md5": "B7F60DB0F30C9D8DE6E8C4EF285DDEE7"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B28B52E"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N6A5", "uniProtkbId": "A0AAJ6N6A5_9ANNE", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Alvinella pompejana", "taxonId": 6376, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8GJ9"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Sedentaria", "Canalipalpata", "Terebellida", "Terebelliformia", "Alvinellidae", "Alvinella"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8GJ9"}], "value": "Rad51c"}}]}, "features": [{"type": "Binding site", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJ9"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105"}}, {"type": "Disulfide bond", "location": {"start": {"value": 46, "modifier": "EXACT"}, "end": {"value": 46, "modifier": "EXACT"}}, "description": "Interchain", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJ9"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJ9"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJ9"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJ9"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}], "references": [{"referenceNumber": 1, "citation": {"id": "37488098", "citationType": "journal article", "authors": ["Longo M.A.", "Roy S.", "Chen Y.", "Tomaszowski K.H.", "Arvai A.S.", "Pepper J.T.", "Boisvert R.A.", "Kunnimalaiyaan S.", "Keshvani C.", "Schild D.", "Bacolla A.", "Williams G.J.", "Tainer J.A.", "Schlacher K."], "citationCrossReferences": [{"database": "PubMed", "id": "37488098"}, {"database": "DOI", "id": "10.1038/s41467-023-40096-1"}], "title": "RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.", "publicationDate": "2023", "journal": "Nat. Commun.", "firstPage": "4445", "lastPage": "4445", "volume": "14"}, "referencePositions": ["X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH ZN(2+)", "DISULFIDE BONDS"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJ9"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8GJ9", "properties": [{"key": "Method", "value": "X-ray"}, {"key": "Resolution", "value": "1.60 A"}, {"key": "Chains", "value": "A/B=1-65"}]}, {"database": "SMR", "id": "A0AAJ6N6A5", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0000166", "properties": [{"key": "GoTerm", "value": "F:nucleotide binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR010995", "properties": [{"key": "EntryName", "value": "DNA_repair_Rad51/TF_NusA_a-hlx"}]}, {"database": "SUPFAM", "id": "SSF47794", "properties": [{"key": "EntryName", "value": "Rad51 N-terminal domain-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "GHMNRLLTSFPLTASVRTKLHNKGFQTVGDVLELKPTELSAELEICKEEALEIIKFLEEETQKVK", "length": 65, "molWeight": 7383, "crc64": "2F323C39B92910EC", "md5": "EB232062632DAF20133A53E96BD50F9D"}, "extraAttributes": {"countByFeatureType": {"Binding site": 1, "Disulfide bond": 1}, "uniParcId": "UPI0027403126"}, "cluster_size": 1, "family": "Alvinellidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8HMC4", "uniProtkbId": "A0AAU8HMC4_9HYME", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Scaptotrigona mexicana", "taxonId": 596862, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI10635.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Hymenoptera", "Apocrita", "Aculeata", "Apoidea", "Anthophila", "Apidae", "Scaptotrigona"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI10635.1"}], "value": "Odorant binding protein 4"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI10635.1"}], "value": "Obp4"}}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-334V2VO1Q3KKB", "citationType": "submission", "authors": ["Leon-Estrada N.", "Garcia-Fajardo L.V.", "Rojas-Leon J.C.", "Guillen-Navarro K."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI10635.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP977268", "properties": [{"key": "ProteinId", "value": "XCI10635.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKSMYESNSEEQMKKLGCFEACVFQKLHFMDGNTLNVEKLESGTRELTPDDFTEDVHEIIEQCVSKVSSSALAKLQTKTNAWLPENISIALWKK", "length": 94, "molWeight": 10730, "crc64": "989DEBAE8BF2C9B8", "md5": "92B8F85CD0F416CBDFB1898BBACFA035"}, "extraAttributes": {"uniParcId": "UPI0035D3D054"}, "cluster_size": 1, "family": "Apidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJK3", "uniProtkbId": "A0AAU7LJK3_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28287.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28287.1"}], "value": "MADS92"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28287.1"}], "value": "MADS92"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28287.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28287.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400927", "properties": [{"key": "ProteinId", "value": "XBP28287.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000987", "properties": [{"key": "GoTerm", "value": "F:cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00266", "properties": [{"key": "EntryName", "value": "MADS_SRF_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050142", "properties": [{"key": "EntryName", "value": "MADS-box/MEF2_TF"}]}, {"database": "InterPro", "id": "IPR033897", "properties": [{"key": "EntryName", "value": "SRF-like_MADS-box"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR48019", "properties": [{"key": "EntryName", "value": "SERUM RESPONSE FACTOR HOMOLOG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGRGKLPLELITKEKSRRTTFEKRKKGLMKKTYELSTLCGVKVCLLIFDYNNPLAEPETFPSNAEQVRSLVNKFEADQTETKKNLTLHDFYRARLKKVKKEIEGNRAQEHNRQISDFPSWDDRLNGFSIDQLFELLNLMQNKIEALDQQIIMKNIMTQKSSIPVLDHHMIFDPYNYNPSLYSTLNNPPHFKNTENVPFGLNCSNAVVPDNSCSSMMDLLMNNKGYCGDVEDRNSSRSFSMYGNEKLKTPMEPWKLENINENEDVSFSKIMPIHSFLPQQFHQQFPSHHLRHSIMPNYSTSSSSSDHKQFQRFHYGFEYYPYDYSHTTSGFN", "length": 331, "molWeight": 38671, "crc64": "8C88E6F0AC37558F", "md5": "23AFF11EAF285DF0C57403E74BC62801"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D32A4B"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEG5", "uniProtkbId": "A0AB38ZEG5_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02669.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02669.1"}], "value": "Heteropteran venom family 1 protein 2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 143, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044312199"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02669.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517419", "properties": [{"key": "ProteinId", "value": "WXI02669.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MKCAIILLAFGCLFAGSYGETKFDKIYRNARFQYKLAYVALHNQVFGATGVELGLAKTDEERDCITNAKKAAIEDGDRLLGETVGKIVPPMDKLYESGTEEEKSAYVDKFDYEEFKKSAMEDFKKKLMKWVPAQQEKMASCRK", "length": 143, "molWeight": 16232, "crc64": "87A69701B49B4C9C", "md5": "B0216FF265AE2E011689934589A17E65"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C2E19"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTM9", "uniProtkbId": "A0AAT9UTM9_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41685.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41685.1"}], "value": "Cytochrome P450 3638G3"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 463, "modifier": "EXACT"}, "end": {"value": 463, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41685.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117245", "properties": [{"key": "ProteinId", "value": "WIM41685.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51257", "properties": [{"key": "EntryName", "value": "PROKAR_LIPOPROTEIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSTTMRSILVNFYWIFGSCVFMILVRTIVHRTFTYIRQMRRMTPLLNSLDHLPTKPIIGSLYYLIKDTKDFMTERGEKVIELISKYESAIFWMMHVPIVSLGKHEDIQAVLNNSRCSRKFLRLLEGTLGDSIFVLHGEKWRRSRKILLAAFSPNRFHRFFSIIKEYSSFTTKALELFCDTDEIIDIKHYILSLNANSFVRNISDYEINKSNNEDIAMINAVIEIARLECTRFLIPWLHPKFIYKTYLFFLGKLHLYREILQLPKKIIKERSMCNMTRNLQNDKIAEDTDTASPELFIDMLLQRHNGDADFTEKHIRAEIFSVISAGYETTAATVCNVLLMLAMHLEVQEKVYDEIKTVFGNDDREVQIEDVKKLVYMEQCINETLRKFAVIPSTLRVHNEDIMLSDGHIIPAGCLIFLGFYLSHHDKTFFPNADNWDPERFSPERYGDCKNAFLPFGGGPRLCIGTKYAMASIKTQLVHLIRRYHFSTEMKMQDIHLVLDILLRNDSGYWLKLHSRPKN", "length": 519, "molWeight": 60719, "crc64": "CB8256BD5E62BBEB", "md5": "5BCBD2F353B17E103F753FFB2CDB93CE"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D26EAA"}, "cluster_size": 3, "family": "Pseudococcidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P9WEJ3", "secondaryAccessions": ["A0AAT9JAW2"], "uniProtkbId": "YM106_YEAST", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "commonName": "Baker's yeast", "taxonId": 559292, "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Saccharomycotina", "Saccharomycetes", "Saccharomycetales", "Saccharomycetaceae", "Saccharomyces"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Uncharacterized protein YMR106W-A"}}}, "genes": [{"orderedLocusNames": [{"evidences": [{"evidenceCode": "ECO:0000312", "source": "SGD", "id": "S000350097"}], "value": "YMR106W-A"}]}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 87, "modifier": "EXACT"}}, "description": "Uncharacterized protein YMR106W-A", "featureId": "PRO_0000461174"}], "keywords": [{"id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "9169872", "citationType": "journal article", "authors": ["Bowman S.", "Churcher C.M.", "Badcock K.", "Brown D.", "Chillingworth T.", "Connor R.", "Dedman K.", "Devlin K.", "Gentles S.", "Hamlin N.", "Hunt S.", "Jagels K.", "Lye G.", "Moule S.", "Odell C.", "Pearson D.", "Rajandream M.A.", "Rice P.", "Skelton J.", "Walsh S.V.", "Whitehead S.", "Barrell B.G."], "citationCrossReferences": [{"database": "PubMed", "id": "9169872"}, {"database": "DOI", "id": "10.1038/387s090"}], "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.", "publicationDate": "1997", "journal": "Nature", "firstPage": "90", "lastPage": "93", "volume": "387"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"value": "ATCC 204508 / S288c", "type": "STRAIN"}]}, {"referenceNumber": 2, "citation": {"id": "24374639", "citationType": "journal article", "authors": ["Engel S.R.", "Dietrich F.S.", "Fisk D.G.", "Binkley G.", "Balakrishnan R.", "Costanzo M.C.", "Dwight S.S.", "Hitz B.C.", "Karra K.", "Nash R.S.", "Weng S.", "Wong E.D.", "Lloyd P.", "Skrzypek M.S.", "Miyasato S.R.", "Simison M.", "Cherry J.M."], "citationCrossReferences": [{"database": "PubMed", "id": "24374639"}, {"database": "DOI", "id": "10.1534/g3.113.008995"}], "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "publicationDate": "2014", "journal": "G3 (Bethesda)", "firstPage": "389", "lastPage": "398", "volume": "4"}, "referencePositions": ["GENOME REANNOTATION"], "referenceComments": [{"value": "ATCC 204508 / S288c", "type": "STRAIN"}]}, {"referenceNumber": 3, "citation": {"id": "34897464", "citationType": "journal article", "authors": ["Engel S.R.", "Wong E.D.", "Nash R.S.", "Aleksander S.", "Alexander M.", "Douglass E.", "Karra K.", "Miyasato S.R.", "Simison M.", "Skrzypek M.S.", "Weng S.", "Cherry J.M."], "citationCrossReferences": [{"database": "PubMed", "id": "34897464"}, {"database": "DOI", "id": "10.1093/genetics/iyab224"}], "title": "New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources.", "publicationDate": "2022", "journal": "Genetics", "firstPage": "iyab224", "lastPage": "iyab224", "volume": "220"}, "referencePositions": ["GENOME REANNOTATION"], "referenceComments": [{"value": "ATCC 204508 / S288c", "type": "STRAIN"}]}, {"referenceNumber": 4, "citation": {"id": "38048358", "citationType": "journal article", "authors": ["Wacholder A.", "Carvunis A.R."], "citationCrossReferences": [{"database": "PubMed", "id": "38048358"}, {"database": "DOI", "id": "10.1371/journal.pbio.3002409"}], "title": "Biological factors and statistical limitations prevent detection of most noncanonical proteins by mass spectrometry.", "publicationDate": "2023", "journal": "PLoS Biol.", "firstPage": "e3002409", "lastPage": "e3002409", "volume": "21"}, "referencePositions": ["IDENTIFICATION BY MASS SPECTROMETRY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "BK006946", "properties": [{"key": "ProteinId", "value": "DBA54441.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "RefSeq", "id": "NP_001418070.1", "properties": [{"key": "NucleotideSequenceId", "value": "NM_001431141.1"}]}, {"database": "GeneID", "id": "91000624", "properties": [{"key": "Description", "value": "-"}]}, {"database": "SGD", "id": "S000350097", "properties": [{"key": "GeneName", "value": "YMR106W-A"}]}, {"database": "Proteomes", "id": "UP000002311", "properties": [{"key": "Component", "value": "Chromosome XIII"}]}], "sequence": {"value": "MISMEAINNFIKTAPKHDYLTGGVHHSGNVDVLQLSGNKEDGSLVWNHTFVDVDNNVVAKFEDALEKLESLHRRSSSSTGNEEHANV", "length": 87, "molWeight": 9604, "crc64": "303B4FA72C0FD51F", "md5": "E75F51F2C6693317D504FF176B48CD00"}, "extraAttributes": {"countByFeatureType": {"Chain": 1}, "uniParcId": "UPI001A52B532"}, "cluster_size": 1, "family": "Saccharomycetaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ4VMR0", "uniProtkbId": "A0AAQ4VMR0_MOUSE", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159964.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159964.1"}], "value": "Membrane metallo-endopeptidase-like 1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159964.1"}, {"evidenceCode": "ECO:0000313", "source": "MGI", "id": "MGI:1351603"}], "value": "Mmel1"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004606"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004606"}], "value": "Single-pass type II membrane protein", "id": "SL-9906"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 42, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 75, "modifier": "EXACT"}, "end": {"value": 307, "modifier": "EXACT"}}, "description": "Peptidase M13 N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF05649"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ4VMR0"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022968"}], "id": "KW-0735", "category": "Domain", "name": "Signal-anchor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "19468303", "citationType": "journal article", "authoringGroup": ["Mouse Genome Sequencing Consortium"], "authors": ["Church D.M.", "Goodstadt L.", "Hillier L.W.", "Zody M.C.", "Goldstein S.", "She X.", "Bult C.J.", "Agarwala R.", "Cherry J.L.", "DiCuccio M.", "Hlavina W.", "Kapustin Y.", "Meric P.", "Maglott D.", "Birtle Z.", "Marques A.C.", "Graves T.", "Zhou S.", "Teague B.", "Potamousis K.", "Churas C.", "Place M.", "Herschleb J.", "Runnheim R.", "Forrest D.", "Amos-Landgraf J.", "Schwartz D.C.", "Cheng Z.", "Lindblad-Toh K.", "Eichler E.E.", "Ponting C.P."], "citationCrossReferences": [{"database": "PubMed", "id": "19468303"}, {"database": "DOI", "id": "10.1371/journal.pbio.1000112"}], "title": "Lineage-specific biology revealed by a finished genome assembly of the mouse.", "publicationDate": "2009", "journal": "PLoS Biol.", "firstPage": "e1000112", "lastPage": "e1000112", "volume": "7"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159964.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159964.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}]}, {"referenceNumber": 2, "citation": {"id": "21750661", "citationType": "journal article", "authors": ["Church D.M.", "Schneider V.A.", "Graves T.", "Auger K.", "Cunningham F.", "Bouk N.", "Chen H.C.", "Agarwala R.", "McLaren W.M.", "Ritchie G.R.", "Albracht D.", "Kremitzki M.", "Rock S.", "Kotkiewicz H.", "Kremitzki C.", "Wollam A.", "Trani L.", "Fulton L.", "Fulton R.", "Matthews L.", "Whitehead S.", "Chow W.", "Torrance J.", "Dunn M.", "Harden G.", "Threadgold G.", "Wood J.", "Collins J.", "Heath P.", "Griffiths G.", "Pelan S.", "Grafham D.", "Eichler E.E.", "Weinstock G.", "Mardis E.R.", "Wilson R.K.", "Howe K.", "Flicek P.", "Hubbard T."], "citationCrossReferences": [{"database": "PubMed", "id": "21750661"}], "title": "Modernizing reference genome assemblies.", "publicationDate": "2011", "journal": "PLoS Biol.", "firstPage": "e1001091", "lastPage": "e1001091", "volume": "9"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159964.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159964.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}]}, {"referenceNumber": 3, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159964.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159964.1"}]}], "uniProtKBCrossReferences": [{"database": "SMR", "id": "A0AAQ4VMR0", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENSMUST00000249868.1", "properties": [{"key": "ProteinId", "value": "ENSMUSP00000159964.1"}, {"key": "GeneId", "value": "ENSMUSG00000058183.17"}]}, {"database": "AGR", "id": "MGI:1351603", "properties": [{"key": "Description", "value": "-"}]}, {"database": "MGI", "id": "MGI:1351603", "properties": [{"key": "GeneName", "value": "Mmel1"}]}, {"database": "GeneTree", "id": "ENSGT00940000157799", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000000589", "properties": [{"key": "Component", "value": "Chromosome 4"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004222", "properties": [{"key": "GoTerm", "value": "F:metalloendopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.390.10", "properties": [{"key": "EntryName", "value": "Collagenase (Catalytic Domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.1380.10", "properties": [{"key": "EntryName", "value": "Neutral endopeptidase , domain2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR024079", "properties": [{"key": "EntryName", "value": "MetalloPept_cat_dom_sf"}]}, {"database": "InterPro", "id": "IPR000718", "properties": [{"key": "EntryName", "value": "Peptidase_M13"}]}, {"database": "InterPro", "id": "IPR042089", "properties": [{"key": "EntryName", "value": "Peptidase_M13_dom_2"}]}, {"database": "InterPro", "id": "IPR008753", "properties": [{"key": "EntryName", "value": "Peptidase_M13_N"}]}, {"database": "PANTHER", "id": "PTHR11733:SF141", "properties": [{"key": "EntryName", "value": "MEMBRANE METALLO-ENDOPEPTIDASE-LIKE 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11733", "properties": [{"key": "EntryName", "value": "ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF05649", "properties": [{"key": "EntryName", "value": "Peptidase_M13_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55486", "properties": [{"key": "EntryName", "value": "Metalloproteases ('zincins'), catalytic domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51885", "properties": [{"key": "EntryName", "value": "NEPRILYSIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVERAGWCRKKSPGFVEYGLMVLLLLLLLGAIVTLGVFYSIALRDSSLKSDICTTPSCVIAAARILENMDQSRNPCENFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKGVLEDSTSQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLSVLKMVGGWPVAMDKWNETMGLKWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFQEDNNHKVRKAYLEFMTSVATMLRKDQNLSKESAMVREEMAEVLELETHLANATVPQEKRHDVTALYHRMDLMELQERFGLKGFSV", "length": 315, "molWeight": 36391, "crc64": "D5F602FD582E9068", "md5": "0F31B7BED8E83AD9700F7095A4A957B8"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1}, "uniParcId": "UPI0032C58E78"}, "cluster_size": 1, "family": "Muridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0NPC6", "uniProtkbId": "A0AAN0NPC6_9BACL", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paenibacillus sp. FPU-7", "taxonId": 762821, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8W7P"}], "lineage": ["Bacteria", "Bacillati", "Bacillota", "Bacilli", "Bacillales", "Paenibacillaceae", "Paenibacillus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8W7P"}], "value": "Extracellular domain of a sensor histidine kinase NagS"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 5, "modifier": "EXACT"}, "end": {"value": 243, "modifier": "EXACT"}}, "description": "Cache", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02743"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8W7P"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38059852", "citationType": "journal article", "authors": ["Itoh T.", "Ogawa T.", "Hibi T.", "Kimoto H."], "citationCrossReferences": [{"database": "PubMed", "id": "38059852"}, {"database": "DOI", "id": "10.1093/bbb/zbad173"}], "title": "Characterization of the extracellular domain of sensor histidine kinase NagS from Paenibacillus sp. str. FPU-7: nagS interacts with oligosaccharide binding protein NagB1 in complexes with N, N'-diacetylchitobiose.", "publicationDate": "2024", "journal": "Biosci. Biotechnol. Biochem.", "firstPage": "294", "lastPage": "304", "volume": "88"}, "referencePositions": ["X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS)"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8W7P"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8W7P", "properties": [{"key": "Method", "value": "X-ray"}, {"key": "Resolution", "value": "1.80 A"}, {"key": "Chains", "value": "A/B=1-274"}]}, {"database": "SMR", "id": "A0AAN0NPC6", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "InterPro", "id": "IPR033479", "properties": [{"key": "EntryName", "value": "dCache_1"}]}, {"database": "Pfam", "id": "PF02743", "properties": [{"key": "EntryName", "value": "dCache_1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSQHMIEQNYAEQSEFTLKAIGRNINYVLKEANHFSESSMLREDIQQTLSINHEVDQVVLAEYNRLLQRTFLFYTPSYSVHLYNFTGQLYNQGKIGYERFTYESLYKSPQVSEVIKLNGKPLWLGPYEFTESSANPNLFTSIRMINNTYTMNNMGILLQQFQFNNELNEIFNYFGTTHSKAVRFMLVNQEGLIMMDNKGKLSGRKLSDYAGSPVVLGAEYQSRKMTFDQVESVVSVHHLALDDFGKMNWNVVSVTPWEYLSGRSEQLEHHHHHH", "length": 274, "molWeight": 31919, "crc64": "5134A8CC45A78184", "md5": "362D6A82D13777411F10AF56BB3F5C8F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI002B4186E4"}, "cluster_size": 1, "family": "Paenibacillaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJJ5", "uniProtkbId": "A0AAU7LJJ5_CEREL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Cervus elaphus", "commonName": "Red deer", "taxonId": 9860, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28626.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Laurasiatheria", "Artiodactyla", "Ruminantia", "Pecora", "Cervidae", "Cervinae", "Cervus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28626.1"}], "value": "Transmembrane protein 183A"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28626.1"}], "value": "TMEM183A"}}], "features": [{"type": "Region", "location": {"start": {"value": 85, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 105, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28626.1"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28626.1"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-E18AOKK6JUCU4", "citationType": "submission", "authors": ["Zheng Q."], "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28626.1"}], "value": "351", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28626.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP839277", "properties": [{"key": "ProteinId", "value": "XBP28626.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0019005", "properties": [{"key": "GoTerm", "value": "C:SCF ubiquitin ligase complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0031647", "properties": [{"key": "GoTerm", "value": "P:regulation of protein stability"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR026509", "properties": [{"key": "EntryName", "value": "TMEM183"}]}, {"database": "PANTHER", "id": "PTHR20988", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN 183A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR20988:SF2", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN 183A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MARGPGPLTRPRPDTVVMPKRGKRLKFRAQDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEASQVPAVEALSGAGEPCDIIDSSGETDAQEESIHERTISRKKKSKRHRVA", "length": 116, "molWeight": 12491, "crc64": "866BD25585CD57F3", "md5": "10D23E15B9F69D472F56280A78F461C3"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D32347"}, "cluster_size": 2, "family": "Cervidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PB67", "uniProtkbId": "A0AAU6PB67_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20565.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20565.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20565.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20565.1"}], "value": "U_LCTX_24_Cm33", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20565.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480834", "properties": [{"key": "ProteinId", "value": "WXB20565.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "KRYFLDFTFDIKINIMSKLLLLCLASVLFAQLSAVNAINYRPIYKEQDE", "length": 49, "molWeight": 5771, "crc64": "DDBE507CC59E1682", "md5": "A9C3024DE5E7BFBB863A80179D104D70"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D382B7"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2Y9", "uniProtkbId": "A0AA96S2Y9_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50074.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50074.1"}], "value": "Collagen alpha-1(IV) chain"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 68, "modifier": "EXACT"}, "end": {"value": 609, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 68, "modifier": "EXACT"}, "end": {"value": 77, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 116, "modifier": "EXACT"}, "end": {"value": 145, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 175, "modifier": "EXACT"}, "end": {"value": 188, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 198, "modifier": "EXACT"}, "end": {"value": 207, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 208, "modifier": "EXACT"}, "end": {"value": 224, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 263, "modifier": "EXACT"}, "end": {"value": 296, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 358, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 384, "modifier": "EXACT"}, "end": {"value": 393, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 495, "modifier": "EXACT"}, "end": {"value": 504, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 510, "modifier": "EXACT"}, "end": {"value": 519, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 526, "modifier": "EXACT"}, "end": {"value": 539, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 540, "modifier": "EXACT"}, "end": {"value": 549, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 565, "modifier": "EXACT"}, "end": {"value": 581, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 593, "modifier": "EXACT"}, "end": {"value": 609, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50074.1"}], "id": "KW-0176", "category": "Domain", "name": "Collagen"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50074.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460151", "properties": [{"key": "ProteinId", "value": "WNS50074.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005581", "properties": [{"key": "GoTerm", "value": "C:collagen trimer"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR008160", "properties": [{"key": "EntryName", "value": "Collagen"}]}, {"database": "InterPro", "id": "IPR050938", "properties": [{"key": "EntryName", "value": "Collagen_Structural_Proteins"}]}, {"database": "PANTHER", "id": "PTHR37456:SF6", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR37456", "properties": [{"key": "EntryName", "value": "SI:CH211-266K2.1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01391", "properties": [{"key": "EntryName", "value": "Collagen"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEGYKEKKQPFCLSGSFLLAFCVVTFTIAVFEGIGGVVMWTHFSAEQSTLRSEVQDLKANFYEITSDLTQEPQTEATEASRAARDALPTDGYYKPKYPYPPTTNCKCPPGPPGLPGQTGGPGGPGKPGATGGPGAPGKPGVGYPGPQGPAGKTGQPGQPGPAGKPGRGEKGEMGNPGKPGSNGKPGQNGEPGQDGTPGETGGQGKPGNDGQPGKDGQPGDNGEPGQPGPEGPKGNDGQPGKPGRQGPKGDSGNPGKNGQPGMDGEPGQDGKPGPQGPQGSKGDMGTPGLPGKSGKPGSKGEPGDAGQNGQPGEDGQPGENGQPGEDGQPGKPGSQGAKGDMGNPGQPGKAGRQGPKGDAGTPGRPGDDGTPGQDGKPGSDGEPGEMGGQGPKGDNGTPGTDGKPGRQGPKGDMGNPGQNGQPGEDGQPGMDGTPGDNGAQGPKGDAGMPGQPGKDGRPGSMGDAGTPGKPGAKGDQGNPGTPGKPGTPGEDGDDGNPGGPGMKGSTGSPGKPGAGGKPGTPGVDGDDGKPGRPGMKGDRGNPGGPGKPGTPGRPGEDGDNGKSGQPGQKGNMGNMGNSGKPGRPGQDGDDGKSGQTGQKGQKGQASQTKGCTCYNKYGHRYWSSTGSCKSGFWCKW", "length": 636, "molWeight": 61902, "crc64": "96F19DA2BD95D255", "md5": "8B038E1E8BC2B09DE5C2793E880C6C58"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Region": 1, "Compositional bias": 14}, "uniParcId": "UPI002B2B2669"}, "cluster_size": 3, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEW4", "uniProtkbId": "A0AB38ZEW4_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02814.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001625"}], "value": "Protease inhibitor"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001625"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00029459"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001625"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}], "value": "Belongs to the protease inhibitor I19 family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001625"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 93, "modifier": "EXACT"}}, "description": "Protease inhibitor", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001625"}], "featureId": "PRO_5044050211"}, {"type": "Domain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "Pacifastin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51446"}]}, {"type": "Domain", "location": {"start": {"value": 61, "modifier": "EXACT"}, "end": {"value": 93, "modifier": "EXACT"}}, "description": "Pacifastin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51446"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 47, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 74, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 77, "modifier": "EXACT"}, "end": {"value": 87, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022690"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001625"}], "id": "KW-0646", "category": "Molecular function", "name": "Protease inhibitor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001625"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022900"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001625"}], "id": "KW-0722", "category": "Molecular function", "name": "Serine protease inhibitor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001625"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02814.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517564", "properties": [{"key": "ProteinId", "value": "WXI02814.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004867", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "InterPro", "id": "IPR008037", "properties": [{"key": "EntryName", "value": "Pacifastin_dom"}]}, {"database": "InterPro", "id": "IPR036201", "properties": [{"key": "EntryName", "value": "Pacifastin_dom_sf"}]}, {"database": "InterPro", "id": "IPR016307", "properties": [{"key": "EntryName", "value": "Prtase-inh_pacifastin"}]}, {"database": "Pfam", "id": "PF05375", "properties": [{"key": "EntryName", "value": "Pacifastin_I"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PIRSF", "id": "PIRSF001625", "properties": [{"key": "EntryName", "value": "Prot_inhib_pacifastin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57283", "properties": [{"key": "EntryName", "value": "PMP inhibitors"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS51446", "properties": [{"key": "EntryName", "value": "PACIFASTIN"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MKFAVILLLTGLTIAVVSAGKKCDKPGEKFDDGCNRCKCTKGGMLACTKRLCQSKKVKREAKECVPGTTWNDGCNLCTCSDDGLALCTRMGCK", "length": 93, "molWeight": 9971, "crc64": "439272277641D61D", "md5": "E3183DA411F8B595CE0E68D294B41514"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2, "Disulfide bond": 5}, "uniParcId": "UPI00388C0863"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LP79", "uniProtkbId": "A0AAN0LP79_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 4.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34097.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012658"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361188"}], "value": "Glucosylceramidase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012658"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361188"}], "value": "3.2.1.45"}]}}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:13269"}, {"database": "ChEBI", "id": "CHEBI:4167"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:22801"}, {"database": "ChEBI", "id": "CHEBI:52639"}], "ecNumber": "3.2.1.45", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001013"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:13270"}, "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001013"}]}]}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:81447"}, {"database": "ChEBI", "id": "CHEBI:4167"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:83264"}, {"database": "ChEBI", "id": "CHEBI:83273"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00050474"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:81448"}, "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00050474"}]}]}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:34755"}, {"database": "ChEBI", "id": "CHEBI:4167"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:70815"}, {"database": "ChEBI", "id": "CHEBI:70846"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00051345"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:34756"}, "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00051345"}]}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004760"}], "value": "Lipid metabolism; sphingolipid metabolism"}], "commentType": "PATHWAY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004991"}], "value": "Sphingolipid metabolism"}], "commentType": "PATHWAY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005382"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361188"}], "value": "Belongs to the glycosyl hydrolase 30 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 370, "modifier": "EXACT"}, "end": {"value": 720, "modifier": "EXACT"}}, "description": "Glycosyl hydrolase family 30 TIM-barrel", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02055"}]}, {"type": "Domain", "location": {"start": {"value": 731, "modifier": "EXACT"}, "end": {"value": 791, "modifier": "EXACT"}}, "description": "Glycosyl hydrolase family 30 beta sandwich", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF17189"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361188"}], "id": "KW-0326", "category": "Molecular function", "name": "Glycosidase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361188"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023098"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361188"}], "id": "KW-0443", "category": "Biological process", "name": "Lipid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022919"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361188"}], "id": "KW-0746", "category": "Biological process", "name": "Sphingolipid metabolism"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34097.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155023", "properties": [{"key": "ProteinId", "value": "WRW34097.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005764", "properties": [{"key": "GoTerm", "value": "C:lysosome"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0005774", "properties": [{"key": "GoTerm", "value": "C:vacuolar membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0004348", "properties": [{"key": "GoTerm", "value": "F:glucosylceramidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0005102", "properties": [{"key": "GoTerm", "value": "F:signaling receptor binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0006066", "properties": [{"key": "GoTerm", "value": "P:alcohol metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0006914", "properties": [{"key": "GoTerm", "value": "P:autophagy"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0006680", "properties": [{"key": "GoTerm", "value": "P:glucosylceramide catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030259", "properties": [{"key": "GoTerm", "value": "P:lipid glycosylation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0007040", "properties": [{"key": "GoTerm", "value": "P:lysosome organization"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0051129", "properties": [{"key": "GoTerm", "value": "P:negative regulation of cellular component organization"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0010605", "properties": [{"key": "GoTerm", "value": "P:negative regulation of macromolecule metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0051247", "properties": [{"key": "GoTerm", "value": "P:positive regulation of protein metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0016241", "properties": [{"key": "GoTerm", "value": "P:regulation of macroautophagy"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0042391", "properties": [{"key": "GoTerm", "value": "P:regulation of membrane potential"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0032006", "properties": [{"key": "GoTerm", "value": "P:regulation of TOR signaling"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0008202", "properties": [{"key": "GoTerm", "value": "P:steroid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "3.20.20.80:FF:000030", "properties": [{"key": "EntryName", "value": "Lysosomal acid glucosylceramidase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.20.20.80", "properties": [{"key": "EntryName", "value": "Glycosidases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.1180", "properties": [{"key": "EntryName", "value": "Golgi alpha-mannosidase II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR033452", "properties": [{"key": "EntryName", "value": "GH30_C"}]}, {"database": "InterPro", "id": "IPR001139", "properties": [{"key": "EntryName", "value": "Glyco_hydro_30"}]}, {"database": "InterPro", "id": "IPR033453", "properties": [{"key": "EntryName", "value": "Glyco_hydro_30_TIM-barrel"}]}, {"database": "InterPro", "id": "IPR013780", "properties": [{"key": "EntryName", "value": "Glyco_hydro_b"}]}, {"database": "InterPro", "id": "IPR017853", "properties": [{"key": "EntryName", "value": "Glycoside_hydrolase_SF"}]}, {"database": "PANTHER", "id": "PTHR11069", "properties": [{"key": "EntryName", "value": "GLUCOSYLCERAMIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11069:SF23", "properties": [{"key": "EntryName", "value": "LYSOSOMAL ACID GLUCOSYLCERAMIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02055", "properties": [{"key": "EntryName", "value": "Glyco_hydro_30"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF17189", "properties": [{"key": "EntryName", "value": "Glyco_hydro_30C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00843", "properties": [{"key": "EntryName", "value": "GLHYDRLASE30"}]}, {"database": "SUPFAM", "id": "SSF51445", "properties": [{"key": "EntryName", "value": "(Trans)glycosidases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKVISISLLFCTAPFIISKSKSKENYFDGYQGLIYNSFFPKKIFNLTLFEGNNCFIGHRLGKNMFSGMLGEMKKKKIDMAIINLRIDFGLDDFYFSPIIFESSAVYYYFFKFKFKLSNKSNLITTLKDLAEHSLIYPVLTKNGQLQSLFNSSKSKLNSIIWKKINKKGLSKTLITLKDNNVNTNLRLLKFIKDNNFAYIINKHNIDFIKLGYCSDFYQSIKEKDDYILNISQDFASNLNSMPYNSNIKKSLKKKLDNHFSYYLPFGFIEQAQRILPFNLKKNFVSKNSHCFEAEITLKFEKLNDPFYIQEFLNHKPLIKKNLTDGFINIYESTESGLRFSFRQTPFNDISLTDVQEIKIKLNLTDTKQKIVGFGGSFTDAACENLQKTNKEIRDQIIIDYFSENGLEYNLGRTTIGGSDFSSRNYTLDDYEYDYDLKNFSLTYEDLDYKIPIIKMALKHQPNLKLIATSWSPPIWLKTNKKIYGKGKLIGNKVTDKSYVTYAKYFVKFLDAYKKEGIKIDSITAANEPSNGNDPDWNFNCIGFKNDEMRDFIVKTLKPILEKAGYGKNELKFYIVDENIDNIKYYADTIMADPIAKEYVYGIAFHWYFNFYGDYDVLTELHEKYPNLELSSTEACNGFEKTEKAVIIGSWSRAVNYAKDIILDLNRWTSSWIDWNLVLDERGGPNWVDNFVDAPIIINLKTNTYIRQPMFYALAHFSKFLKKNYLALNYKIKSDANQTKNFYFSAFRNEKNEVVVVVNNNRDKNLKVSISLTNDKNNVFNILSLKNSIQTYVWKN", "length": 795, "molWeight": 92631, "crc64": "4A8B6323EB22BDA3", "md5": "9185BDC0265AA3BC4A5306A78F235ACA"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 3, "PATHWAY": 2, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2}, "uniParcId": "UPI0032504B06"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZE79", "uniProtkbId": "A0AB38ZE79_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71727.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71727.1"}], "value": "Venom redulysin 4"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 366, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044339964"}, {"type": "Coiled coil", "location": {"start": {"value": 107, "modifier": "EXACT"}, "end": {"value": 160, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71727.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510802", "properties": [{"key": "ProteinId", "value": "WXH71727.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSKLWLLLLLVAAAYAYPANPDEDEDVGYLEDPGVMDNVIDAEEELEDYMEEDPEKGTMDILKEAWGRFKKLGKKELKKIIGIMKKKFCSQQNDFEEDEELEDEPKKGGLAAKLKALQQKMKELKKKAKEMYANNKQKLKEELKKVNKWLCDRLEKLDQQEDVEEFEEDGDDEERGFGSFLKKLVKKVSSFAKKNMKKGLKFLKKNAVKITPLECEGKTCKSCVKSIVQLSACVEMTLERNGKESSLNMKITVNGDSKWEKNIKLGDVPSCYDIGKPIGKICCKGLQGKGKSSKGQANVNFCLAIVAPDHGVGCKFCASYQDKKFKVKMSPKLFAGTIAEDGDIVEIAKNGEDAQALLGPDEYELD", "length": 366, "molWeight": 41129, "crc64": "B85CB4ECAA812F48", "md5": "BF57FC19156E4F9F896AB4825F5B18FD"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Coiled coil": 1}, "uniParcId": "UPI00388BF6FF"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEE7", "uniProtkbId": "A0AB38ZEE7_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02667.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02667.1"}], "value": "Venom redulysin 3"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 454, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044325050"}, {"type": "Coiled coil", "location": {"start": {"value": 97, "modifier": "EXACT"}, "end": {"value": 142, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 202, "modifier": "EXACT"}, "end": {"value": 233, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02667.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517417", "properties": [{"key": "ProteinId", "value": "WXI02667.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSKFWLLLLCVSAFQAVHSYPALEDYYLEDPAQSTWEILKEGWDKLSDKYNQMGKDAAAKFIAAFKNRFCKNIESDEDFEEDQGEPTVQVKLVRRVLELLRKAKKAIGDEKKQIKEEIEGMRRKICSELNDVEEDLDEMEEDPQQSTWSILKDAMGKLKDRWTGLAKEKQKQITDYLEKKFCSEQNDFEEDVPQGLSKSEIVQKIQDALKSLKDKYGNQKDKMIEEVNKLKQRFCAQLIASSKQNDVDEDEGDEERGINWGKWADKIKKGLKKISKSMLKGMKKGAKFLKDKAIKVTPIKCEGKSCKSCISLTIPMKQSVCAQFTLLKTNKATYLIVALTVNDEAKLEQKIKIGEVPRCMNIGEPIGKLCMKGLEGKAKSSKGQANANFCLVILAEKYNCGVKICAKYEDKKFKVKFSPKLFAGGQSEDGDIVELDEKEESGVTLDADEFEIDE", "length": 454, "molWeight": 51613, "crc64": "1AEF71D93285B092", "md5": "FF303A668D3A2AE530A3372465833AA1"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Coiled coil": 2}, "uniParcId": "UPI00388C2081"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEB2", "uniProtkbId": "A0AB38ZEB2_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71759.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71759.1"}], "value": "Heteropteran venom family 16 protein 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 120, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044322433"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71759.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510834", "properties": [{"key": "ProteinId", "value": "WXH71759.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MWAWLPLFLLGTSQLIYFSSAGEMSEHELAIVHKLEETFGPDWAKKVPGIAERLKHLGKHLEAGNSLEAGKFQPWEQAEINLKWKKFLHKVGHVAEQIGKKAAGAAIGKLVGDAAAAAIG", "length": 120, "molWeight": 13066, "crc64": "02161EBB6B000685", "md5": "DA776841FD16FAA03744C28C7DF19D29"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C0E96"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7YDG2", "uniProtkbId": "A0AAU7YDG2_CLIPA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Clitopilus passeckerianus", "commonName": "Pleurotus passeckerianus", "taxonId": 648682, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87421.1"}], "lineage": ["Eukaryota", "Fungi", "Dikarya", "Basidiomycota", "Agaricomycotina", "Agaricomycetes", "Agaricomycetidae", "Agaricales", "Tricholomatineae", "Entolomataceae", "Clitopilus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87421.1"}], "value": "Clitopilene synthase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87421.1"}], "value": "TS1"}}], "references": [{"referenceNumber": 1, "citation": {"id": "38904208", "citationType": "journal article", "authors": ["Li H.", "Goldfuss B.", "Dickschat J.S."], "citationCrossReferences": [{"database": "PubMed", "id": "38904208"}], "title": "Mechanistic characterisation of the diterpene synthase for clitopilene and identification of isopentalenene synthase from the fungus Clitopilus passeckerianus.", "publicationDate": "2024", "journal": "Chem. Commun. (Camb.)", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87421.1"}], "value": "DSM 1602", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87421.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP777465", "properties": [{"key": "ProteinId", "value": "XBY87421.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.600.10", "properties": [{"key": "EntryName", "value": "Farnesyl Diphosphate Synthase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008949", "properties": [{"key": "EntryName", "value": "Isoprenoid_synthase_dom_sf"}]}, {"database": "Pfam", "id": "PF19086", "properties": [{"key": "EntryName", "value": "Terpene_syn_C_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48576", "properties": [{"key": "EntryName", "value": "Terpenoid synthases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVSVLSTALCKRPNFVSRFPANEHFDRGVIAENVQWYLSEKWPWKSDAERERYLTKDFEGWGLMILGDAPSDRTEAACLWFSWLFLWDDMVEKMSSSEARLSLVQLAEIFSDTRIPKDPTPIERIALAIRDMLLEVDDDDLRDLGRSILTQVCHFFTAIGSKQDRARAFAGGFDSFIKYRLNDVGGRLALELLLWARGCIIPPNAKSTGLADLVNISLLHATLINDFFSYEVEAEVLRELEFSGRKKHGYMVFNTVAVLMAEKSMSRTDAYVELIEKIKVVEKRYVKALDDLRIRHRESGEDLTRIEEVSDVLVDLMGGNSVWSETCGRYNPA", "length": 333, "molWeight": 38034, "crc64": "0F5872E23E4BC8F6", "md5": "239DA801D8B665186D806065AA44C354"}, "extraAttributes": {"uniParcId": "UPI0035D3BF33"}, "cluster_size": 1, "family": "Entolomataceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJ90", "uniProtkbId": "A0AAU7LJ90_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28196.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28196.1"}], "value": "MADS1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28196.1"}], "value": "MADS1"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 8, "modifier": "EXACT"}, "end": {"value": 68, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}, {"type": "Coiled coil", "location": {"start": {"value": 99, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28196.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28196.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400836", "properties": [{"key": "ProteinId", "value": "XBP28196.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00265", "properties": [{"key": "EntryName", "value": "MADS_MEF2_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.1810.10:FF:000006", "properties": [{"key": "EntryName", "value": "Agamous-like MADS-box protein AGL62"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR033896", "properties": [{"key": "EntryName", "value": "MEF2-like_N"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR11945", "properties": [{"key": "EntryName", "value": "MADS BOX PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11945:SF534", "properties": [{"key": "EntryName", "value": "MYOCYTE-SPECIFIC ENHANCER FACTOR 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVSKKKTQGRQKIEIKKIENKNSSQVTFSKRRTGLFKKACELSVLCDVEVATIVFSNNNKAFCFGHPSIENVLHRYLHNSSSSSLLSFSSSSISRVSDASVLEEFNREYMEAVKELEEKKKALNMEDFQHSSQPWWEYINVDFGMELEELVHMKIALEELRKKVLAKVKDRQDHELMIMANNNTNSDGFMATAQLPLNSTM", "length": 201, "molWeight": 23073, "crc64": "68FE2A70FBA161FA", "md5": "A4D84B3609BF8A0F59DD61408A98EB1C"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Coiled coil": 1}, "uniParcId": "UPI0035D2B2F5"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NP70", "uniProtkbId": "A0AA96NP70_GYMSY", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Gymnema sylvestre", "commonName": "Gurmar", "synonyms": ["Periploca sylvestris"], "taxonId": 4068, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99863.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "asterids", "lamiids", "Gentianales", "Apocynaceae", "Asclepiadoideae", "Marsdenieae", "Gymnema"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99863.1"}], "value": "Disease resistance protein RPS2"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99863.1"}], "value": "RPS2"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008894"}], "value": "Belongs to the disease resistance NB-LRR family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 132, "modifier": "EXACT"}, "end": {"value": 354, "modifier": "EXACT"}}, "description": "NB-ARC", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00931"}]}, {"type": "Domain", "location": {"start": {"value": 806, "modifier": "EXACT"}, "end": {"value": 871, "modifier": "EXACT"}}, "description": "Disease resistance protein At4g27190-like leucine-rich repeats", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF23247"}]}, {"type": "Domain", "location": {"start": {"value": 969, "modifier": "EXACT"}, "end": {"value": 1110, "modifier": "EXACT"}}, "description": "Disease resistance protein At4g27190-like leucine-rich repeats", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF23247"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99863.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022614"}], "id": "KW-0433", "category": "Domain", "name": "Leucine-rich repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022821"}], "id": "KW-0611", "category": "Biological process", "name": "Plant defense"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8JD0E4S7VLN46", "citationType": "submission", "authors": ["Kalariya K.A."], "title": "Transcriptomic revealing of plant pathogen interaction in Gymnema sylvestre.", "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99863.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR484765", "properties": [{"key": "ProteinId", "value": "WNT99863.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043531", "properties": [{"key": "GoTerm", "value": "F:ADP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006952", "properties": [{"key": "GoTerm", "value": "P:defense response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.10.8.430", "properties": [{"key": "EntryName", "value": "Helical domain of apoptotic protease-activating factors"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.80.10.10", "properties": [{"key": "EntryName", "value": "Ribonuclease Inhibitor"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Gene3D", "id": "1.10.10.10", "properties": [{"key": "EntryName", "value": "Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR042197", "properties": [{"key": "EntryName", "value": "Apaf_helical"}]}, {"database": "InterPro", "id": "IPR057135", "properties": [{"key": "EntryName", "value": "At4g27190-like_LRR"}]}, {"database": "InterPro", "id": "IPR032675", "properties": [{"key": "EntryName", "value": "LRR_dom_sf"}]}, {"database": "InterPro", "id": "IPR002182", "properties": [{"key": "EntryName", "value": "NB-ARC"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR050905", "properties": [{"key": "EntryName", "value": "Plant_NBS-LRR"}]}, {"database": "InterPro", "id": "IPR036388", "properties": [{"key": "EntryName", "value": "WH-like_DNA-bd_sf"}]}, {"database": "PANTHER", "id": "PTHR33463", "properties": [{"key": "EntryName", "value": "NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR33463:SF198", "properties": [{"key": "EntryName", "value": "RPP4C3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23247", "properties": [{"key": "EntryName", "value": "LRR_RPS2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Pfam", "id": "PF00931", "properties": [{"key": "EntryName", "value": "NB-ARC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00364", "properties": [{"key": "EntryName", "value": "DISEASERSIST"}]}, {"database": "SUPFAM", "id": "SSF52058", "properties": [{"key": "EntryName", "value": "L domain-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "EHGKLITIKNAVEQRILVARRDLQEPSPHIQEWLKGVETMNSKVLWIRQHRERVERGCLYGCGPNLKWRYLLGGEARKKIDEIVKLCNEAKEHVSFSVPTASMGFESVATEAMAEFESRKYIEVDAISALKDTHANVIGLCGMGGVGKTLMAKKIGKIMKEEKIFHEVVMALVGQDPEPNKIQGEIAVGLGLTLGEGNRADRLYTRLMDEKKILIILDDVWRWIDLNELGIPSPDRHRGCKILLTSRNRSVCFQMKAKWIFTIPILPEAEAWSVFRQMACNNSNIEDPQVLAIARNVARECKGLPIALVNVGRSMRNKSKRSWEDALVQLRKATPRTISGLLDDVYRPLKLSYTSLESDVAKTLFLMCCLFEEDSHIPVDLLIRYVMGLHIFPDVENLEEARNSVHGLLETLKDSSLLDDSEEEDYVRMHDVVRDVAMFIAADKFLINHNIVSKKWPRRPTFQQFTHISLISGAFDELPESLDCPNLEMLLLECNFQPLKAADSLFIETKVLKVLEMRNLCIPSLPSSLKLCTSLRTLQLHFCKFVKDISDVEEDRSKEVLSVIAELVNLEILSFSYSTIKALPCAIGNLRNLRLLDLTGCKHLNVIQSGIISSLVNLEEIYLKKSFSNWGAEIEGKGHNMSLAELESLLHLTTLTILIPETHLIPRNFQLPSTLTKYDLSIGQPPEKSKEIYKEIGKNYEKIVCFNLSLPHSFGLSLLQMLKNAECLYSRGDGSCSAIEALAPEGFQNLKQLRLENCYGLQHLANTKDMVTEDICSIFPVLEKIYLTGISCLKEICNGKLPAGSFEKLRHLDFKQLPMLIHLWRSPALGISLANLIFISIDECHRLQYLFSLSIARSLQQLEQLKVNECNMMEEIVAAENGSSLNEIEFPRLRSLGLDKLGNFDRFCRWFDYIHFPQLCILRLNNLPNLKNIFHEKDGSTSSVVQAETDHQLHSLFNEKKSFESLQFLELYKLANVTNLWSRKMATGLFRALEGLKVVSCHGLRNLFPSSVAKGLVNLKELEVRDCSTMEEIIEKEDEEGEGKEKSKLSLFPELEMLRLVTLDDLNRFSHLKHQLELKSLEHLEINNCPKFDTFNPGSTDTPKLEVLKIDDQRLETNDLNTTIQQLLQEKQEEVPSKNYIASSSEGRYWIPVIHNLFNKGGG", "length": 1163, "molWeight": 132199, "crc64": "071C39F49B169467", "md5": "4DD177AFB16A6D2F5B503C9BC926C453"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 3, "Non-terminal residue": 1}, "uniParcId": "UPI002B3218A8"}, "cluster_size": 2, "family": "Apocynaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MMY8", "uniProtkbId": "A0AA96MMY8_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50033.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50033.1"}], "value": "Collagen alpha-6(VI) chain-like protein"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 74, "modifier": "EXACT"}, "end": {"value": 245, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50033.1"}], "id": "KW-0176", "category": "Domain", "name": "Collagen"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50033.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460110", "properties": [{"key": "ProteinId", "value": "WNS50033.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005581", "properties": [{"key": "GoTerm", "value": "C:collagen trimer"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd19941", "properties": [{"key": "EntryName", "value": "TIL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00111", "properties": [{"key": "EntryName", "value": "Trefoil"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.10.25.10", "properties": [{"key": "EntryName", "value": "Laminin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR000519", "properties": [{"key": "EntryName", "value": "P_trefoil_dom"}]}, {"database": "InterPro", "id": "IPR036084", "properties": [{"key": "EntryName", "value": "Ser_inhib-like_sf"}]}, {"database": "InterPro", "id": "IPR002919", "properties": [{"key": "EntryName", "value": "TIL_dom"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF90", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA-1(XXI) CHAIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01826", "properties": [{"key": "EntryName", "value": "TIL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00088", "properties": [{"key": "EntryName", "value": "Trefoil"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00453", "properties": [{"key": "EntryName", "value": "VWFADOMAIN"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57567", "properties": [{"key": "EntryName", "value": "Serine protease inhibitors"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNVSGTCVPKDNCCTVPGAVYLDWGTCVATCDAPEPLCGDCMPACGCPEGYVLHQAACIPRTDCPTVPCSNKTDIVLLVDSSASVCRKKFTRAQNFLATLVEKLPIGENTIRVAEVIYGLHPELVFSLPAYSTAGTLSHAIRNVEYARKCSTKTGKAIQFVVDYYSGLLSGRFGTNRILIVVTDGKSMDDVQTAAKNARQAGFNVIAIGVGAYADAEELMMITGSEGKVVMVAAYSVLQTVCAQIWDIINVCCYYGISQDDCEAKECCWNEETLLIHVVKIEEELKRMYLNFEFKLCVFTILIGVTVSCSIISP", "length": 314, "molWeight": 34060, "crc64": "54D2B2E8EFE15FC8", "md5": "F39C92222CF2BC2B8FA91510DD35579E"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI002B2F2DF9"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU12", "uniProtkbId": "A0AAT9UU12_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41607.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41607.1"}], "value": "Cytochrome P450 6PV1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 445, "modifier": "EXACT"}, "end": {"value": 445, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41607.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117167", "properties": [{"key": "ProteinId", "value": "WIM41607.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000042", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNEELLSSILFVLITWLLYVIIQYIRTYTYWKKRGVPQITPIPFFGNTFSVTCGEEPLYHFHYKNYFKFKDHPFGGYYDFGRPVLLVRDPELINHILTKDFAYFQDRGFPYDEEKEPLTANLFNMGGPRWKNIRTKITPCFTTGKRKLMFEMLKNCMDDLKNIVRSNLRNDEDVEFKDILARFSTDIITESAFGIKAHTLKNPEAEFRQMGRSLIQPNSRIRPIFLQICPKLMQYFGVRFLSQEMNDFFQGFVKEAVEFRKTNHVNRNDFLNSMVQLMENQTKEESGRDITYASIAAECWFFFFAGFEASSSALSMTLYELARNPEIQRKVREEVDRVVEKYDGEITYDALQEMTYMEMVIYETIRLYPSLPFLIRSCTKTYKIPNSDTYIDKGVSVVIPVVGLHRDPVYYTDPEVYNPENFSEEVKNSRHHCTFLPFGEGPRICIASRFGMMQIKTGLATLIRNFEFTPSSKMITPLQLIPRLILTNCGSGVWLKCSERSFN", "length": 503, "molWeight": 58935, "crc64": "3D33E163FE2E09C4", "md5": "CCB20F4DBD5D818E8BF30D091C332591"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D2A83D"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QKS9", "uniProtkbId": "A0AAU0QKS9_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56447.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56447.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 38, "modifier": "EXACT"}, "end": {"value": 57, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 123, "modifier": "EXACT"}, "end": {"value": 143, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 149, "modifier": "EXACT"}, "end": {"value": 170, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 177, "modifier": "EXACT"}, "end": {"value": 200, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 248, "modifier": "EXACT"}, "end": {"value": 268, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56447.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56447.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56447.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970340", "properties": [{"key": "ProteinId", "value": "WPO56447.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIMDIDIPVFEDFFRIIKLNLWISGIPFNGSKIQYRFYFLYISIVLILIEEGCFLVVKYSPENLLELTKLAPCSCFGLLSVLKILPIALKREKISRLTQSLDALYSTLLSNPKKKGIVAKEMILVKLLLKYFFLLNAILNVVYNFSTLIITFCNYVVSGEVIFSLPYAVIVPFSTEIWFNWIIVYLHSILCGATCGLFLITVDALYYVLTSQICSHLAVISSEINELDESNEHLLRGLVMNHLYMLRYFMLWIYVIMPGKVIFSIVTVKQPKFHMNERVQTLILGGLQVSVPMKVRYVAEPMTVSVE", "length": 307, "molWeight": 35243, "crc64": "AAB2220DEE1C3A8C", "md5": "A9B90B050644F06FB5B222DC0F630947"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 6}, "uniParcId": "UPI00308687DC"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0Z1V1", "uniProtkbId": "A0AAF0Z1V1_HEDDI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hediste diversicolor", "commonName": "Sandworm", "synonyms": ["Nereis diversicolor"], "taxonId": 126592, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPC85594.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Errantia", "Phyllodocida", "Nereididae", "Hediste", "Hediste diversicolor species group"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPC85594.1"}], "value": "Front-end fatty acid desaturase group B"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009295"}], "value": "Belongs to the fatty acid desaturase type 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 120, "modifier": "EXACT"}, "end": {"value": 140, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 254, "modifier": "EXACT"}, "end": {"value": 278, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 290, "modifier": "EXACT"}, "end": {"value": 310, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 9, "modifier": "EXACT"}, "end": {"value": 86, "modifier": "EXACT"}}, "description": "Cytochrome b5 heme-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50255"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023098"}], "id": "KW-0443", "category": "Biological process", "name": "Lipid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9LTOMUJ9LUE38", "citationType": "submission", "authors": ["Villena A."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPC85594.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ941904", "properties": [{"key": "ProteinId", "value": "WPC85594.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016717", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006629", "properties": [{"key": "GoTerm", "value": "P:lipid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd03506", "properties": [{"key": "EntryName", "value": "Delta6-FADS-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.120.10", "properties": [{"key": "EntryName", "value": "Cytochrome b5-like heme/steroid binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001199", "properties": [{"key": "EntryName", "value": "Cyt_B5-like_heme/steroid-bd"}]}, {"database": "InterPro", "id": "IPR036400", "properties": [{"key": "EntryName", "value": "Cyt_B5-like_heme/steroid_sf"}]}, {"database": "InterPro", "id": "IPR005804", "properties": [{"key": "EntryName", "value": "FA_desaturase_dom"}]}, {"database": "InterPro", "id": "IPR012171", "properties": [{"key": "EntryName", "value": "Fatty_acid_desaturase"}]}, {"database": "PANTHER", "id": "PTHR19353:SF88", "properties": [{"key": "EntryName", "value": "DELTA(5) FATTY ACID DESATURASE FAT-4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR19353", "properties": [{"key": "EntryName", "value": "FATTY ACID DESATURASE 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00173", "properties": [{"key": "EntryName", "value": "Cyt-b5"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00487", "properties": [{"key": "EntryName", "value": "FA_desaturase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF015921", "properties": [{"key": "EntryName", "value": "FA_sphinglp_des"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00363", "properties": [{"key": "EntryName", "value": "CYTOCHROMEB5"}]}, {"database": "SMART", "id": "SM01117", "properties": [{"key": "EntryName", "value": "Cyt-b5"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55856", "properties": [{"key": "EntryName", "value": "Cytochrome b5-like heme/steroid binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50255", "properties": [{"key": "EntryName", "value": "CYTOCHROME_B5_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGKGTNVQHRTFSWNEVQEHTELNDRWIVIDNSIYDVSRFQKIHPGGAKIISHFAGQDATEVWLAMHKNQELAKKYMKSIYVGQVKDVMNYDAEREERQRDMEEIRQVAIKNGWFESNPVFFIAQFLSIVMFEFLGYLVFLYNGSGWMSYFGACLFLATAQAQLGWTMHDYGHWSVVKNRKLSHAVQQFYMGFMKGASKHWWNFRHNRHHAKTNIYKKDPDITFPKDVFLFGTRIPVIFGKMGKKNMPYNYEHIYFWLFGPAMLLPVVVNLEIIYYLIKRRDRFALRDTLAIIGFFCRYTLIYGSFVGGLWGAVKLYFFVRFLESFWFTMVTQMSHIPMKVDFDAGDDWLVSQTLSTQNIESSPWNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVKSVCEKHHLPYMVKPMLTAMKEIISSLRTSGELWYEAYHHQ", "length": 438, "molWeight": 51799, "crc64": "7D697EC1591D9A65", "md5": "680B985CA15FA2E05A8502B5D9AFF77A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 3, "Domain": 1}, "uniParcId": "UPI002B3108AE"}, "cluster_size": 1, "family": "Nereididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0UHZ9", "uniProtkbId": "A0AAU0UHZ9_9PLEO", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Didymella segeticola", "taxonId": 2021029, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRK57383.1"}], "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Pezizomycotina", "Dothideomycetes", "Pleosporomycetidae", "Pleosporales", "Pleosporineae", "Didymellaceae", "Didymella"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRK57383.1"}], "value": "Uncharacterized protein"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRK57383.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1CP78AQUA35D3", "citationType": "submission", "authors": ["Wang Y."], "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRK57383.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR987684", "properties": [{"key": "ProteinId", "value": "WRK57383.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MWKKPGKLQLPHLPHLVGP", "length": 19, "molWeight": 2177, "crc64": "7A325F2D3507B969", "md5": "7EF473DFE8C9F255CEF027D880A1EE88"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D38A3F"}, "cluster_size": 1, "family": "Didymellaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFF0", "uniProtkbId": "A0AAU7VFF0_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67471.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67471.1"}], "value": "Piwi-like protein 1A"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67471.1"}], "value": "piwi1A"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00038291"}], "value": "Belongs to the argonaute family. Piwi subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 351, "modifier": "EXACT"}, "end": {"value": 463, "modifier": "EXACT"}}, "description": "PAZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50821"}]}, {"type": "Domain", "location": {"start": {"value": 627, "modifier": "EXACT"}, "end": {"value": 919, "modifier": "EXACT"}}, "description": "Piwi", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50822"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 12, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 42, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 89, "modifier": "EXACT"}, "end": {"value": 107, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022782"}], "id": "KW-0221", "category": "Biological process", "name": "Differentiation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023158"}], "id": "KW-0943", "category": "Biological process", "name": "RNA-mediated gene silencing"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67471.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67471.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750676", "properties": [{"key": "ProteinId", "value": "XBW67471.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0030154", "properties": [{"key": "GoTerm", "value": "P:cell differentiation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0031047", "properties": [{"key": "GoTerm", "value": "P:regulatory ncRNA-mediated gene silencing"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd02845", "properties": [{"key": "EntryName", "value": "PAZ_piwi_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd04658", "properties": [{"key": "EntryName", "value": "Piwi_piwi-like_Euk"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.420.10:FF:000014", "properties": [{"key": "EntryName", "value": "Piwi-like RNA-mediated gene silencing 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.170.260.10:FF:000003", "properties": [{"key": "EntryName", "value": "Piwi-like RNA-mediated gene silencing 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.170.260.10", "properties": [{"key": "EntryName", "value": "paz domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.10", "properties": [{"key": "EntryName", "value": "Ribonuclease H-like superfamily/Ribonuclease H"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR003100", "properties": [{"key": "EntryName", "value": "PAZ_dom"}]}, {"database": "InterPro", "id": "IPR036085", "properties": [{"key": "EntryName", "value": "PAZ_dom_sf"}]}, {"database": "InterPro", "id": "IPR003165", "properties": [{"key": "EntryName", "value": "Piwi"}]}, {"database": "InterPro", "id": "IPR012337", "properties": [{"key": "EntryName", "value": "RNaseH-like_sf"}]}, {"database": "InterPro", "id": "IPR036397", "properties": [{"key": "EntryName", "value": "RNaseH_sf"}]}, {"database": "PANTHER", "id": "PTHR22891", "properties": [{"key": "EntryName", "value": "EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02170", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02171", "properties": [{"key": "EntryName", "value": "Piwi"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23278", "properties": [{"key": "EntryName", "value": "Piwi_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00949", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00950", "properties": [{"key": "EntryName", "value": "Piwi"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF101690", "properties": [{"key": "EntryName", "value": "PAZ domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53098", "properties": [{"key": "EntryName", "value": "Ribonuclease H-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50821", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50822", "properties": [{"key": "EntryName", "value": "PIWI"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDGRGRGRARGRGRGDQPQQQGAAQPGAAAQPRASEPTQQTRPGPPPQQLQQQQLGAGSGDPRWAQPQQQPVPRYVAPTAVGDQPPSRPGGGGEGVMVPGGNGGGPGRAAHRGGAARPGASVEQLEAGVAGIVMADAMGGRPRRGALMFRAEPRTRPETAADKRGTAGRQVALCTNQFHLQRAQQFHLYQYHVDFNPEVPNTRMRKGMLHTFKELLGPISLFDGTILFLPLRLELDTTEVYTQRISDDEKIRVTIKFTNEIPSTSPMCMQLYNITFKKVLTHIGLQLIGRNYYHPNLAAKIPQHKLEVWPGYETSILQLEVWPGYETSILQFESGPMLSVDVSHKILSMASAYDVMQDCFQQGPRGDVQDRVKARLIGQIVLTRYNNKTYRVDDIDFSRTPASTFEKKDKSLISFVEYYQTAHNFRIQREDQPLLISMPKRRDERAGVKGPICLIPELCTVTGLEEKVRTDFNVMKDLAQHTRLDPNKRVAKYRELRNNIQQNAEAMRDLNNWNIGLSNELVQLQGRQLPPENIHQGDLDFNGGEQADWTKQMRALRMQRLVHLSSWIVVCPQKNGRNAEDLIRALRDVSHGLGLELSNPTALPINNDNTQTYKEALQNAITPTTRMVVCVLPTNRKDRYDALKCLLCCDIPVPSQMILSRTLSKPQMLMSVATKVLIQMNCKMGGEVWHLDVPMGGTMVVGIDTYHDSSQRGRSVAGVAASLNKSLTRYYTSWSFQNTHEELVNGLTASLAKCLQKYKEVNKVLPIKVIVFRDGVGDGQLGMVNDHELPQILQCFARIDPDYKPGLGFVVVKKRISSRFFMRAGNNYSNPPPGTIIDDVATRPEWYDYFVISQSVRQGTVTPTHYNIIHDTTRLQPDHYQRLTYKLCHLYYNWSGTIRVPAPCQYAHKVAFLVGQSLHRNPHESLADKLFFL", "length": 933, "molWeight": 104709, "crc64": "4EFAA122197480F5", "md5": "CA3733A797D0080BD26ADBDEEB212FA9"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2, "Region": 1, "Compositional bias": 3}, "uniParcId": "UPI0035D29378"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PAW8", "uniProtkbId": "A0AAU6PAW8_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20562.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20562.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20562.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20562.1"}], "value": "U_LCTX_7_Cm30", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20562.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480831", "properties": [{"key": "ProteinId", "value": "WXB20562.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "TYCIKVRIMFRLILVFAMVTLLTYLSKVDATLIDAPEIDIEPKYKALTPYQQFVQYHMRRKARLEAQKAAAAAAAKN", "length": 77, "molWeight": 8835, "crc64": "342848E28EE0529B", "md5": "470C90053C0CF9FB110060D7E32B7FAC"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D2D787"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXW6", "uniProtkbId": "TXU45_MEGOP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Megalopyge opercularis", "commonName": "Southern flannel moth", "synonyms": ["Phalaena opercularis"], "taxonId": 1113279, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Megalopygidae", "Megalopyge"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-megalopygitoxin(4)-Mo5"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-MPTX(4)-Mo5"}, {"evidences": [{"evidenceCode": "ECO:0000312", "source": "EMBL", "id": "WJJ70368.1"}], "value": "U-MPTX.4-5"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Probable toxin"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Expressed by the venom apparatus"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Larvae"}], "commentType": "DEVELOPMENTAL STAGE"}, {"commentType": "MASS SPECTROMETRY", "method": "MALDI", "molWeight": 1944.05, "molWeightError": 0.0, "note": "Monoisotopic mass.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the caterpillar 4 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Peptide", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "U-megalopygitoxin(4)-Mo5", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "featureId": "PRO_0000461524"}], "keywords": [{"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "37428925", "citationType": "journal article", "authors": ["Walker A.A.", "Robinson S.D.", "Merritt D.J.", "Cardoso F.C.", "Goudarzi M.H.", "Mercedes R.S.", "Eagles D.A.", "Cooper P.", "Zdenek C.N.", "Fry B.G.", "Hall D.W.", "Vetter I.", "King G.F."], "citationCrossReferences": [{"database": "PubMed", "id": "37428925"}, {"database": "DOI", "id": "10.1073/pnas.2305871120"}], "title": "Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).", "publicationDate": "2023", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "e2305871120", "lastPage": "e2305871120", "volume": "120"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "MASS SPECTROMETRY", "SYNTHESIS OF 24-40", "SUBCELLULAR LOCATION", "TISSUE SPECIFICITY", "DEVELOPMENTAL STAGE"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP514850", "properties": [{"key": "ProteinId", "value": "WJJ70368.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MKCSLLLVVFAAMVALFAAGTNAAMNQRKMLEVIGGLKKEK", "length": 41, "molWeight": 4397, "crc64": "C15244D20BA9B068", "md5": "A86449A777F7F07ACB84B7B3F30F012A"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "DEVELOPMENTAL STAGE": 1, "MASS SPECTROMETRY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Peptide": 1}, "uniParcId": "UPI00388C33C9"}, "cluster_size": 1, "family": "Megalopygidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB32TWY6", "uniProtkbId": "A0AB32TWY6_DANRE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Danio rerio", "commonName": "Zebrafish", "synonyms": ["Brachydanio rerio"], "taxonId": 7955, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}, {"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068079372.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Cypriniformes", "Danionidae", "Danioninae", "Danio"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068079372.1"}], "value": "Serine hydrolase-like protein isoform X1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068079372.1"}, {"evidenceCode": "ECO:0000313", "source": "ZFIN", "id": "ZDB-GENE-030131-1368"}], "value": "serhl"}, "synonyms": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068079372.1"}], "value": "wu:fb69a04"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068079372.1"}], "value": "zgc:55804"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008645"}], "value": "Belongs to the AB hydrolase superfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 55, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "AB hydrolase-1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00561"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AB32TWY6"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "23594743", "citationType": "journal article", "authoringGroup": ["Genome Reference Consortium Zebrafish"], "authors": ["Howe K.", "Clark M.D.", "Torroja C.F.", "Torrance J.", "Berthelot C.", "Muffato M.", "Collins J.E.", "Humphray S.", "McLaren K.", "Matthews L.", "McLaren S.", "Sealy I.", "Caccamo M.", "Churcher C.", "Scott C.", "Barrett J.C.", "Koch R.", "Rauch G.J.", "White S.", "Chow W.", "Kilian B.", "Quintais L.T.", "Guerra-Assuncao J.A.", "Zhou Y.", "Gu Y.", "Yen J.", "Vogel J.H.", "Eyre T.", "Redmond S.", "Banerjee R.", "Chi J.", "Fu B.", "Langley E.", "Maguire S.F.", "Laird G.K.", "Lloyd D.", "Kenyon E.", "Donaldson S.", "Sehra H.", "Almeida-King J.", "Loveland J.", "Trevanion S.", "Jones M.", "Quail M.", "Willey D.", "Hunt A.", "Burton J.", "Sims S.", "McLay K.", "Plumb B.", "Davis J.", "Clee C.", "Oliver K.", "Clark R.", "Riddle C.", "Elliot D.", "Eliott D.", "Threadgold G.", "Harden G.", "Ware D.", "Begum S.", "Mortimore B.", "Mortimer B.", "Kerry G.", "Heath P.", "Phillimore B.", "Tracey A.", "Corby N.", "Dunn M.", "Johnson C.", "Wood J.", "Clark S.", "Pelan S.", "Griffiths G.", "Smith M.", "Glithero R.", "Howden P.", "Barker N.", "Lloyd C.", "Stevens C.", "Harley J.", "Holt K.", "Panagiotidis G.", "Lovell J.", "Beasley H.", "Henderson C.", "Gordon D.", "Auger K.", "Wright D.", "Collins J.", "Raisen C.", "Dyer L.", "Leung K.", "Robertson L.", "Ambridge K.", "Leongamornlert D.", "McGuire S.", "Gilderthorp R.", "Griffiths C.", "Manthravadi D.", "Nichol S.", "Barker G.", "Whitehead S.", "Kay M.", "Brown J.", "Murnane C.", "Gray E.", "Humphries M.", "Sycamore N.", "Barker D.", "Saunders D.", "Wallis J.", "Babbage A.", "Hammond S.", "Mashreghi-Mohammadi M.", "Barr L.", "Martin S.", "Wray P.", "Ellington A.", "Matthews N.", "Ellwood M.", "Woodmansey R.", "Clark G.", "Cooper J.", "Cooper J.", "Tromans A.", "Grafham D.", "Skuce C.", "Pandian R.", "Andrews R.", "Harrison E.", "Kimberley A.", "Garnett J.", "Fosker N.", "Hall R.", "Garner P.", "Kelly D.", "Bird C.", "Palmer S.", "Gehring I.", "Berger A.", "Dooley C.M.", "Ersan-Urun Z.", "Eser C.", "Geiger H.", "Geisler M.", "Karotki L.", "Kirn A.", "Konantz J.", "Konantz M.", "Oberlander M.", "Rudolph-Geiger S.", "Teucke M.", "Lanz C.", "Raddatz G.", "Osoegawa K.", "Zhu B.", "Rapp A.", "Widaa S.", "Langford C.", "Yang F.", "Schuster S.C.", "Carter N.P.", "Harrow J.", "Ning Z.", "Herrero J.", "Searle S.M.", "Enright A.", "Geisler R.", "Plasterk R.H.", "Lee C.", "Westerfield M.", "de Jong P.J.", "Zon L.I.", "Postlethwait J.H.", "Nusslein-Volhard C.", "Hubbard T.J.", "Roest Crollius H.", "Rogers J.", "Stemple D.L."], "citationCrossReferences": [{"database": "PubMed", "id": "23594743"}, {"database": "DOI", "id": "10.1038/nature12111"}], "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "publicationDate": "2013", "journal": "Nature", "firstPage": "498", "lastPage": "503", "volume": "496"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FT6AD0HQEQTFJ", "citationType": "submission", "authoringGroup": ["RefSeq"], "publicationDate": "APR-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068079372.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068079372.1"}]}], "uniProtKBCrossReferences": [{"database": "RefSeq", "id": "XP_068079372.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_068223271.1"}]}, {"database": "GeneID", "id": "322648", "properties": [{"key": "Description", "value": "-"}]}, {"database": "CTD", "id": "94009", "properties": [{"key": "Description", "value": "-"}]}, {"database": "ZFIN", "id": "ZDB-GENE-030131-1368", "properties": [{"key": "GeneName", "value": "serhl"}]}, {"database": "Proteomes", "id": "UP000000437", "properties": [{"key": "Component", "value": "Chromosome 1"}]}, {"database": "GO", "id": "GO:0016787", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.50.1820", "properties": [{"key": "EntryName", "value": "alpha/beta hydrolase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000073", "properties": [{"key": "EntryName", "value": "AB_hydrolase_1"}]}, {"database": "InterPro", "id": "IPR029058", "properties": [{"key": "EntryName", "value": "AB_hydrolase_fold"}]}, {"database": "InterPro", "id": "IPR050266", "properties": [{"key": "EntryName", "value": "AB_hydrolase_sf"}]}, {"database": "PANTHER", "id": "PTHR43798", "properties": [{"key": "EntryName", "value": "MONOACYLGLYCEROL LIPASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43798:SF14", "properties": [{"key": "EntryName", "value": "SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00561", "properties": [{"key": "EntryName", "value": "Abhydrolase_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53474", "properties": [{"key": "EntryName", "value": "alpha/beta-Hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRGHSQIFYRTDPPLLALVNNQSSRAAGMRRSAEGAQLACCKEFASLINYGSLRSLNTLQWKRFSIIGHSMGGNVAGMFSALYPEMVESVVLLDTYGFLPTEVTDMFTNMRKGINDQIQYDNMANERKERVYTYEKAKERLKVANPYLSDQSADILLERAVREVDGGFVFTRDFRINLKNIIYINIDQCLHVLSQVKAKVMLLLAKDGLFKTFTLPDGYADRICKSWTDQKATFVEVEGDHHVHLNNPEAVSSVITDFLQPQSPDQTESQSGNQTSRL", "length": 278, "molWeight": 31448, "crc64": "C70B29AB06DE710E", "md5": "5EB0C762B7DF0B3584E2BB493A609626"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035A11D14"}, "cluster_size": 8, "family": "Danionidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P9WEJ4", "secondaryAccessions": ["A0AAT9JB48"], "uniProtkbId": "YF035_YEAST", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "commonName": "Baker's yeast", "taxonId": 559292, "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Saccharomycotina", "Saccharomycetes", "Saccharomycetales", "Saccharomycetaceae", "Saccharomyces"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Uncharacterized protein YFR035W-A"}}}, "genes": [{"orderedLocusNames": [{"evidences": [{"evidenceCode": "ECO:0000312", "source": "SGD", "id": "S000350095"}], "value": "YFR035W-A"}]}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000255"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000255"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "Uncharacterized protein YFR035W-A", "featureId": "PRO_0000461173"}, {"type": "Transmembrane", "location": {"start": {"value": 53, "modifier": "EXACT"}, "end": {"value": 71, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000255"}]}], "keywords": [{"id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "7670463", "citationType": "journal article", "authors": ["Murakami Y.", "Naitou M.", "Hagiwara H.", "Shibata T.", "Ozawa M.", "Sasanuma S.", "Sasanuma M.", "Tsuchiya Y.", "Soeda E.", "Yokoyama K.", "Yamazaki M.", "Tashiro H.", "Eki T."], "citationCrossReferences": [{"database": "PubMed", "id": "7670463"}, {"database": "DOI", "id": "10.1038/ng0795-261"}], "title": "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae.", "publicationDate": "1995", "journal": "Nat. Genet.", "firstPage": "261", "lastPage": "268", "volume": "10"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"value": "ATCC 204508 / S288c", "type": "STRAIN"}]}, {"referenceNumber": 2, "citation": {"id": "24374639", "citationType": "journal article", "authors": ["Engel S.R.", "Dietrich F.S.", "Fisk D.G.", "Binkley G.", "Balakrishnan R.", "Costanzo M.C.", "Dwight S.S.", "Hitz B.C.", "Karra K.", "Nash R.S.", "Weng S.", "Wong E.D.", "Lloyd P.", "Skrzypek M.S.", "Miyasato S.R.", "Simison M.", "Cherry J.M."], "citationCrossReferences": [{"database": "PubMed", "id": "24374639"}, {"database": "DOI", "id": "10.1534/g3.113.008995"}], "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "publicationDate": "2014", "journal": "G3 (Bethesda)", "firstPage": "389", "lastPage": "398", "volume": "4"}, "referencePositions": ["GENOME REANNOTATION"], "referenceComments": [{"value": "ATCC 204508 / S288c", "type": "STRAIN"}]}, {"referenceNumber": 3, "citation": {"id": "34897464", "citationType": "journal article", "authors": ["Engel S.R.", "Wong E.D.", "Nash R.S.", "Aleksander S.", "Alexander M.", "Douglass E.", "Karra K.", "Miyasato S.R.", "Simison M.", "Skrzypek M.S.", "Weng S.", "Cherry J.M."], "citationCrossReferences": [{"database": "PubMed", "id": "34897464"}, {"database": "DOI", "id": "10.1093/genetics/iyab224"}], "title": "New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources.", "publicationDate": "2022", "journal": "Genetics", "firstPage": "iyab224", "lastPage": "iyab224", "volume": "220"}, "referencePositions": ["GENOME REANNOTATION"], "referenceComments": [{"value": "ATCC 204508 / S288c", "type": "STRAIN"}]}, {"referenceNumber": 4, "citation": {"id": "38048358", "citationType": "journal article", "authors": ["Wacholder A.", "Carvunis A.R."], "citationCrossReferences": [{"database": "PubMed", "id": "38048358"}, {"database": "DOI", "id": "10.1371/journal.pbio.3002409"}], "title": "Biological factors and statistical limitations prevent detection of most noncanonical proteins by mass spectrometry.", "publicationDate": "2023", "journal": "PLoS Biol.", "firstPage": "e3002409", "lastPage": "e3002409", "volume": "21"}, "referencePositions": ["IDENTIFICATION BY MASS SPECTROMETRY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "BK006940", "properties": [{"key": "ProteinId", "value": "DBA54438.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "RefSeq", "id": "NP_001418067.1", "properties": [{"key": "NucleotideSequenceId", "value": "NM_001431138.1"}]}, {"database": "GeneID", "id": "91000622", "properties": [{"key": "Description", "value": "-"}]}, {"database": "SGD", "id": "S000350095", "properties": [{"key": "GeneName", "value": "YFR035W-A"}]}, {"database": "Proteomes", "id": "UP000002311", "properties": [{"key": "Component", "value": "Chromosome VI"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0140580", "properties": [{"key": "GoTerm", "value": "F:mitochondrion autophagosome adaptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000423", "properties": [{"key": "GoTerm", "value": "P:mitophagy"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR013898", "properties": [{"key": "EntryName", "value": "Atg43"}]}, {"database": "PANTHER", "id": "PTHR38699", "properties": [{"key": "EntryName", "value": "CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR38699:SF1", "properties": [{"key": "EntryName", "value": "MITOPHAGY RECEPTOR ATG43"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNVPTAPTPNKHLNIPDLRFEKVFKKALHRELAPSSSLSRKAGVITKVVVRDVLLMPLLQSFVLSLALMGVKEWLSYIRLKGRTLGDRIRQRLFPI", "length": 96, "molWeight": 10932, "crc64": "D054C80DB951F46E", "md5": "517C7F4D0F35DE58192685F771C8DE03"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Chain": 1, "Transmembrane": 1}, "uniParcId": "UPI000454E04E"}, "cluster_size": 2, "family": "Saccharomycetaceae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXW3", "uniProtkbId": "TXU11_MEGOP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Megalopyge opercularis", "commonName": "Southern flannel moth", "synonyms": ["Phalaena opercularis"], "taxonId": 1113279, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Megalopygidae", "Megalopyge"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-megalopygitoxin(1)-Mo1"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-MPTX(1)-Mo1"}, {"evidences": [{"evidenceCode": "ECO:0000312", "source": "EMBL", "id": "WJJ70362.1"}], "value": "U-MPTX.1-1"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Probable toxin"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Expressed by the venom apparatus"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Larvae"}], "commentType": "DEVELOPMENTAL STAGE"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "value": "Contains 4 disulfide bonds"}], "commentType": "PTM"}, {"commentType": "MASS SPECTROMETRY", "method": "MALDI", "molWeight": 9188.36, "molWeightError": 0.0, "note": "Monoisotopic mass.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the caterpillar 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 98, "modifier": "EXACT"}}, "description": "U-megalopygitoxin(1)-Mo1", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "featureId": "PRO_0000461521"}], "keywords": [{"id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "37428925", "citationType": "journal article", "authors": ["Walker A.A.", "Robinson S.D.", "Merritt D.J.", "Cardoso F.C.", "Goudarzi M.H.", "Mercedes R.S.", "Eagles D.A.", "Cooper P.", "Zdenek C.N.", "Fry B.G.", "Hall D.W.", "Vetter I.", "King G.F."], "citationCrossReferences": [{"database": "PubMed", "id": "37428925"}, {"database": "DOI", "id": "10.1073/pnas.2305871120"}], "title": "Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).", "publicationDate": "2023", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "e2305871120", "lastPage": "e2305871120", "volume": "120"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "MASS SPECTROMETRY", "RECOMBINANT EXPRESSION", "SUBCELLULAR LOCATION", "TISSUE SPECIFICITY", "DEVELOPMENTAL STAGE"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP514844", "properties": [{"key": "ProteinId", "value": "WJJ70362.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR029277", "properties": [{"key": "EntryName", "value": "SVWC_dom"}]}, {"database": "Pfam", "id": "PF15430", "properties": [{"key": "EntryName", "value": "SVWC"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYRETFVFCVLLAVVSANVEMRDLEEKPEKYKGVNCCYVSAIQECIPVGETRPFKHECKGWTCNKDNLLEVSCGKVLVEHYVEDKTAPYPHCCPVAKA", "length": 98, "molWeight": 11133, "crc64": "8C870F89D10C4EAB", "md5": "F1FA4A36B245D6B37A0C6588969F365B"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "DEVELOPMENTAL STAGE": 1, "PTM": 1, "MASS SPECTROMETRY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C33B0"}, "cluster_size": 1, "family": "Megalopygidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QL73", "uniProtkbId": "A0AAU0QL73_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56499.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56499.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56499.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56499.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56499.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970392", "properties": [{"key": "ProteinId", "value": "WPO56499.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MILIYFRFVLANVYLTINISFQAYGNSTMDCMISTFFCTTKTQLQMLKYNLENIVNLDDNSEATEYSPYLDSDLIQRRLRLCVQHHLQILWWDL", "length": 94, "molWeight": 11224, "crc64": "D45ED3D6A71C8F84", "md5": "51260E3801AF401789CAF5980BB71D2C"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "uniParcId": "UPI00308D27D1"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHF2", "uniProtkbId": "A0AAN0LHF2_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34094.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34094.1"}], "value": "G protein-coupled receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 99, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 106, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 146, "modifier": "EXACT"}, "end": {"value": 168, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 189, "modifier": "EXACT"}, "end": {"value": 209, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 343, "modifier": "EXACT"}, "end": {"value": 364, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 869, "modifier": "EXACT"}, "end": {"value": 891, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 903, "modifier": "EXACT"}, "end": {"value": 926, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 89, "modifier": "EXACT"}, "end": {"value": 923, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34094.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155020", "properties": [{"key": "ProteinId", "value": "WRW34094.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24248", "properties": [{"key": "EntryName", "value": "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24248:SF174", "properties": [{"key": "EntryName", "value": "TYRAMINE_OCTOPAMINE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAKLIFPAGHVFLKSDAIYNRLLTANNSIDGSLITNIFYNKTIDNFNSSNLINTTTSLCTSLVDHQSQNSLIIFSMIFMVIVNLVVIFGNLLVIISVFLYSKLRTVTNFFIVSLAVADLLLGLTVLPYSLTQTISKTWYFGEIWCLGWLVIDVWLSTASILNLVAISVDRYLAITQPLKYRTLMTAKRAKTIIASAWILSFLICFPPLVGWNQQGSGLIKVNLTKTLEYKPQIHPSFFSSSLSFETLTKHLTSKSLNSIENLKISIESPKSNSIHKTKTLFKDKSKRIKKRFIRHIGKLEKNKLKNFRFSRSIDSMSLNKTSIDDNCENYEVLQCILFDSKGYVIYSAFGSFFIPMFIMVFFYWRIYLVAMYTTQALNRGYISKKCVRTNLVSGFPNYQSEILNQKDNLTNNTEKVYTNKNLTLRVHRGFVKDNHLLESTQSNLTISNGSCNIKNYNRSSYDSGERQNSTSPTITIRKNNSIDASSAAQFCKKILPSRLSNRLLTSLEKNDDKRLKKIQHRSIRCLDRTQNIVSLAVNVSKNKNIVLKKTRSEQFIADDNLKKNQNKIDTNLDELNLSILNKTDNPEIKNNVNKNLINKEEDKLSLKESTFICFNEINSNLLNSKIEDNIKINNSDWKIKFVKKKLYKKSNTFTLSNSDSEKSFCKLENSIKPISLSSGNLNVKDYNLPKKSLIGELSNKTKIINFNLTEPEKIFYQNKIQLKIDSPKNDSSIEMNKISEDSSLKNDSFTKCNDNYEAIEVLNNKSKIENDSNFDTEITTKKDYLENENVTETMNNGSFDSINKPIFQDNDLTKFHENNLTPSSNKKTKNIVNFTSRLFKRQANNFKTQNNSGKFQAKRYLAETKAAKTVGVIVGGFICCWFPFFTVYLVRGLCEDKNCVPEVLLTIFTWLGYINSALNPIIYGMFSKDFRKAFKNIICKCKFTEETGVTSLIRQIHLPNLFEEDMI", "length": 967, "molWeight": 110711, "crc64": "992CB2705AEF0DA9", "md5": "0702A7C4F3DA3E025730F28E988FE533"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI00324E863B"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJR0", "uniProtkbId": "A0AAU7LJR0_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28234.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28234.1"}], "value": "MADS39"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28234.1"}], "value": "MADS39"}}], "features": [{"type": "Domain", "location": {"start": {"value": 185, "modifier": "EXACT"}, "end": {"value": 247, "modifier": "EXACT"}}, "description": "K-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51297"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28234.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28234.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400874", "properties": [{"key": "ProteinId", "value": "XBP28234.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR002487", "properties": [{"key": "EntryName", "value": "TF_Kbox"}]}, {"database": "Pfam", "id": "PF01486", "properties": [{"key": "EntryName", "value": "K-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51297", "properties": [{"key": "EntryName", "value": "K_BOX"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRAGILNILQGFALPQQISLENRSRDQMHLQKKFEIRFPYIRIAEWFTHLSTGSSILIRPPADFDDSWTGIALYVVVKIHEHDDHFDRSWELKETHFHFSTTENTIAFQNLKSCSPGSYGLCTYVPRGWFAGQFKKATSLEASVSANRPDVEVVRCGIHIILEQDTSLFATDLSRTASEHLKNFETKNIVEVTKLKFKYESLQRTQRHLLGEDLGPLSVKELQNLETQLEAGLAQARQRKFFRSLVA", "length": 247, "molWeight": 28367, "crc64": "A957E0DDDCA7ACE6", "md5": "02163BC8B07DEFE42357993A1E0AE6F2"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D3BC35"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLK4", "uniProtkbId": "A0AAU0QLK4_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56503.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56503.1"}], "value": "Odorant receptor"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 43, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 134, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 173, "modifier": "EXACT"}, "end": {"value": 195, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56503.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56503.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56503.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970396", "properties": [{"key": "ProteinId", "value": "WPO56503.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MDGLEILPEEYVKPFRRCLEVLKRSNIMFPSENSSFWKTNWRFLYMAPLHIMHFLSLTAYIVKIVIEGQDVFQQANVIPMWLVTAEVTVKTTLLLMKRDDLKNVVIHLGSMWRTEGLNEEQILLKKAALKRVKYTEFIFYRISLAVTWQYTMLPLVELTVRRLIFHQDVELQLAFAAIYPFEVTNIYIYLIMYAFQTYCGK", "length": 201, "molWeight": 23861, "crc64": "E067685342935E33", "md5": "4E96CA5C621E15499B40DF62DD0FBB7A"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 3}, "uniParcId": "UPI00308CFE35"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXZ5", "uniProtkbId": "TX2A_XYLAR", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Xylocopa aruana", "commonName": "Great carpenter bee", "taxonId": 135674, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Hymenoptera", "Apocrita", "Aculeata", "Apoidea", "Anthophila", "Apidae", "Xylocopa", "Koptortosoma"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36550366"}, {"evidenceCode": "ECO:0000305"}], "value": "Xylotoxin(2)-Xa2a"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36550366"}], "value": "XYTX(2)-Xa2a"}, {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36550366"}], "value": "XYTX2-Xa2a"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36550366"}], "value": "Toxin with weak activity on calcium-activated potassium (KCa) channels. Causes a small reversible block of human KCa2.1/KCNN1/SK1 and KCa2.2/KCNN2/SK2 (IC(50)=25.1 uM) currents"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36550366"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "36550366"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "36550366"}], "value": "Contains 2 disulfide bonds"}], "commentType": "PTM"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36550366"}], "value": "Negative results: does not show activity against Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA3. Does not elicit any spontaneous pain behaviors after intraplantar injection in mice"}], "commentType": "MISCELLANEOUS"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Propeptide", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 31, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "36550366"}], "featureId": "PRO_0000461568"}, {"type": "Peptide", "location": {"start": {"value": 32, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "Xylotoxin(2)-Xa2a", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36550366"}], "featureId": "PRO_0000461569"}, {"type": "Modified residue", "location": {"start": {"value": 54, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "Alanine amide", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36550366"}]}], "keywords": [{"id": "KW-0027", "category": "PTM", "name": "Amidation"}, {"id": "KW-0903", "category": "Technical term", "name": "Direct protein sequencing"}, {"id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"id": "KW-0872", "category": "Molecular function", "name": "Ion channel impairing toxin"}, {"id": "KW-0632", "category": "Molecular function", "name": "Potassium channel impairing toxin"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}, {"id": "KW-1220", "category": "Molecular function", "name": "Voltage-gated potassium channel impairing toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "36550366", "citationType": "journal article", "authors": ["Shi N.", "Szanto T.G.", "He J.", "Schroeder C.I.", "Walker A.A.", "Deuis J.R.", "Vetter I.", "Panyi G.", "King G.F.", "Robinson S.D."], "citationCrossReferences": [{"database": "PubMed", "id": "36550366"}, {"database": "DOI", "id": "10.1038/s41598-022-26867-8"}], "title": "Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana.", "publicationDate": "2022", "journal": "Sci. Rep.", "firstPage": "22168", "lastPage": "22168", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "PROTEIN SEQUENCE OF 32-54", "IDENTIFICATION BY MASS SPECTROMETRY", "SUBCELLULAR LOCATION", "AMIDATION AT ALA-54", "SYNTHESIS OF 32-54"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}, {"value": "Venom gland", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON586843", "properties": [{"key": "ProteinId", "value": "UTO68650.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015459", "properties": [{"key": "GoTerm", "value": "F:potassium channel regulator activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MKQSLIFCFLLLTIIFASGYAAMPELESRIPSRCNCKAPPNSLPGLLCRKRCMAGK", "length": 56, "molWeight": 6191, "crc64": "720A6D3F97474555", "md5": "F25226E2AD84FA50B87A1A9C462B7AEB"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "PTM": 1, "MISCELLANEOUS": 1}, "countByFeatureType": {"Signal": 1, "Propeptide": 1, "Peptide": 1, "Modified residue": 1}, "uniParcId": "UPI0021FFCFFD"}, "cluster_size": 1, "family": "Apidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEU1", "uniProtkbId": "A0AB38ZEU1_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02781.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02781.1"}], "value": "Venom S1 protease 41"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00024195"}], "value": "Belongs to the peptidase S1 family. CLIP subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 164, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02781.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02781.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02781.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517531", "properties": [{"key": "ProteinId", "value": "WXI02781.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00190", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.40.10.10:FF:000054", "properties": [{"key": "EntryName", "value": "Complement C1r subcomponent"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001314", "properties": [{"key": "EntryName", "value": "Peptidase_S1A"}]}, {"database": "InterPro", "id": "IPR051487", "properties": [{"key": "EntryName", "value": "Ser/Thr_Proteases_Immune/Dev"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24256", "properties": [{"key": "EntryName", "value": "TRYPTASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00722", "properties": [{"key": "EntryName", "value": "CHYMOTRYPSIN"}]}, {"database": "SMART", "id": "SM00020", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVDVRRIIEHQNFNRVTLVNDIAVLVLAEKVTFNQFIGPICLPTEKKDLDHKYVRIIGWGSMNQDGDNSPVLKKVDLRVVPLKTCSYNYAGQVDPAADNQICTFGRRKGSCQGDSGGPVLWLDPETNRYTLLGTVSFGKSCASTIPTVNTHVISYVDWIKRTIEATDREANTCAKTT", "length": 177, "molWeight": 19690, "crc64": "649BEFA1E4444F0D", "md5": "73A2ED201EFBE2C18EC4F2B94C1D4199"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI00388C184B"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0YZX9", "uniProtkbId": "A0AAF0YZX9_HIRNI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hirudo nipponia", "commonName": "Korean blood-sucking leech", "taxonId": 42736, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49279.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Hirudinea", "Hirudinida", "Hirudiniformes", "Hirudinidae", "Hirudo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49279.1"}], "value": "Uncharacterized protein"}}]}, "references": [{"referenceNumber": 1, "citation": {"id": "CI-ANPA6HQVADV17", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49279.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR759985", "properties": [{"key": "ProteinId", "value": "WPD49279.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MGEGYESAANTIREHTQKTKINLKSKQDIERSLSLIVPKVQFKVYNCPDQGIFKEEKHFGKIVLVVDRKNVVIVPPKYYGDEPDLSFALTLMGEGYKKAIKIIQERIENTKIVVQLQRNCTIIWQSTKKKLDYILVEISPDNKVIEPPKFIRVPKE", "length": 156, "molWeight": 18030, "crc64": "FC6A8DC28C3747A6", "md5": "060CEC8C34B2B5F634E4B6E409D379BD"}, "extraAttributes": {"uniParcId": "UPI002B2FF102"}, "cluster_size": 1, "family": "Hirudinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9FG60", "uniProtkbId": "A0AAT9FG60_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Enchytraeus japonensis", "taxonId": 228735, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61266.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012552"}], "value": "RNA helicase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012552"}], "value": "3.6.4.13"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61266.1"}], "value": "Ej-vasa2"}}], "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "ATP + H2O = ADP + phosphate + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:13065"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:43474"}, {"database": "ChEBI", "id": "CHEBI:456216"}], "ecNumber": "3.6.4.13", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047984"}]}}], "features": [{"type": "Domain", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "DEAD-box RNA helicase Q", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51195"}]}, {"type": "Domain", "location": {"start": {"value": 95, "modifier": "EXACT"}, "end": {"value": 281, "modifier": "EXACT"}}, "description": "Helicase ATP-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51192"}]}, {"type": "Domain", "location": {"start": {"value": 293, "modifier": "EXACT"}, "end": {"value": 454, "modifier": "EXACT"}}, "description": "Helicase C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51194"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 464, "modifier": "EXACT"}, "end": {"value": 534, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Motif", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "Q motif", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00552"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 510, "modifier": "EXACT"}, "end": {"value": 527, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022806"}], "id": "KW-0347", "category": "Molecular function", "name": "Helicase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1NS4NNSF9REKQ", "citationType": "submission", "authors": ["Yamaguchi S.", "Fujita T."], "title": "Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61266.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC727639", "properties": [{"key": "ProteinId", "value": "BDR61266.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016787", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003676", "properties": [{"key": "GoTerm", "value": "F:nucleic acid binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003724", "properties": [{"key": "GoTerm", "value": "F:RNA helicase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd18787", "properties": [{"key": "EntryName", "value": "SF2_C_DEAD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.50.300:FF:000008", "properties": [{"key": "EntryName", "value": "ATP-dependent RNA helicase RhlB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.50.300:FF:000397", "properties": [{"key": "EntryName", "value": "Probable ATP-dependent RNA helicase DDX4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011545", "properties": [{"key": "EntryName", "value": "DEAD/DEAH_box_helicase_dom"}]}, {"database": "InterPro", "id": "IPR014001", "properties": [{"key": "EntryName", "value": "Helicase_ATP-bd"}]}, {"database": "InterPro", "id": "IPR001650", "properties": [{"key": "EntryName", "value": "Helicase_C-like"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR014014", "properties": [{"key": "EntryName", "value": "RNA_helicase_DEAD_Q_motif"}]}, {"database": "PANTHER", "id": "PTHR47958", "properties": [{"key": "EntryName", "value": "ATP-DEPENDENT RNA HELICASE DBP3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00270", "properties": [{"key": "EntryName", "value": "DEAD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00271", "properties": [{"key": "EntryName", "value": "Helicase_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00487", "properties": [{"key": "EntryName", "value": "DEXDc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00490", "properties": [{"key": "EntryName", "value": "HELICc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51192", "properties": [{"key": "EntryName", "value": "HELICASE_ATP_BIND_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51194", "properties": [{"key": "EntryName", "value": "HELICASE_CTER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51195", "properties": [{"key": "EntryName", "value": "Q_MOTIF"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAKDCPKASTQDDGKPRPPPYIPPPPPENEEDIFSTITQGINFNRYDEIKVECTGQNIPSRPMESFTDVNFSDVIMTNLRKTKYEKPTPIQKWSIPVIISGRDMMGCAQTGSGKTASFLLPMLTKMLGTGFEPPIVEDGCAMPLMLVMAPTRELVLQIFHETRKFSFDTVVRAVVAYGGVSSSHQEKDILKGAHIVIATPGRLIDFIGKKKINLSKLKYLVLDEVDRMLDMGFHTAIESILSQGESGMPSTNSRQTVVFSATIPEEVQKLAAKLLREDYIFVTVGSVGSANLDIEQYVLLMEQEAKRDKLMEIVQNRGEDKIIIFVEEKRKADFISAFLSQASFATASIHGNLTQAEREKSLRDFRAGVSPILVATNVAARGLDIPEVKHVINYDMPQHIEEYVHRIGRTGRCGNTGKATAFFVAENDNHLARSLVKVLSDAMQEVPEWLEKLAVDNIGMGGFSRPGGGKFGGRDMRSNRPMGYQQQSGPSHYQGDGGYKGDGGSRVRPEAAAARTQPAAKAASPAANEDEDWD", "length": 534, "molWeight": 58802, "crc64": "F621212319705B88", "md5": "E549C6ED95336643B54E307C2A777FC9"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1}, "countByFeatureType": {"Domain": 3, "Region": 2, "Motif": 1, "Compositional bias": 3}, "uniParcId": "UPI0035D2CE71"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8BWH2", "uniProtkbId": "A0AAU8BWH2_9SOLA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Physalis pubescens", "taxonId": 300354, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD29952.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "asterids", "lamiids", "Solanales", "Solanaceae", "Solanoideae", "Physaleae", "Physalis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD29952.1"}], "value": "CLV3"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005416"}], "value": "Belongs to the CLV3/ESR signal peptide family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 45, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022782"}], "id": "KW-0221", "category": "Biological process", "name": "Differentiation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-HO9DBLON1JO8", "citationType": "submission", "authors": ["Liu Q."], "title": "Editing multiple genes in Physalis pubescens provides implications for creating new germplasm and varieties of Physalis crops.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD29952.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP948789", "properties": [{"key": "ProteinId", "value": "XCD29952.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0033612", "properties": [{"key": "GoTerm", "value": "F:receptor serine/threonine kinase binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0030154", "properties": [{"key": "GoTerm", "value": "P:cell differentiation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR044962", "properties": [{"key": "EntryName", "value": "CLV3/ESR"}]}, {"database": "PANTHER", "id": "PTHR36349", "properties": [{"key": "EntryName", "value": "PROTEIN CLAVATA 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR36349:SF2", "properties": [{"key": "EntryName", "value": "PROTEIN CLAVATA 3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MHRIPSGLNGQGDEVLESQWAAFGKGYYNHAEKKINEKFADWELRGVPGGPDPLHHNGVNPKKPRTP", "length": 67, "molWeight": 7475, "crc64": "24500288EF6C043B", "md5": "EDE614330B39C2952DAEA21CF9E66EB5"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Region": 1}, "uniParcId": "UPI0035D2907C"}, "cluster_size": 1, "family": "Solanaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BH21", "uniProtkbId": "A0AAQ5BH21_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519221.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519221.1"}], "value": "Desmoplakin"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519221.1"}], "value": "DSP"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BH21"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BH21"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519221.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "14574404", "citationType": "journal article", "authors": ["Mungall A.J.", "Palmer S.A.", "Sims S.K.", "Edwards C.A.", "Ashurst J.L.", "Wilming L.", "Jones M.C.", "Horton R.", "Hunt S.E.", "Scott C.E.", "Gilbert J.G.", "Clamp M.E.", "Bethel G.", "Milne S.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Andrews T.D.", "Ashwell R.I.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beare D.M.", "Beasley H.", "Beasley O.", "Bird C.P.", "Blakey S.", "Bray-Allen S.", "Brook J.", "Brown A.J.", "Brown J.Y.", "Burford D.C.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Clark S.Y.", "Clark G.", "Clee C.M.", "Clegg S.", "Cobley V.", "Collier R.E.", "Collins J.E.", "Colman L.K.", "Corby N.R.", "Coville G.J.", "Culley K.M.", "Dhami P.", "Davies J.", "Dunn M.", "Earthrowl M.E.", "Ellington A.E.", "Evans K.A.", "Faulkner L.", "Francis M.D.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Ghori M.J.", "Gilby L.M.", "Gillson C.J.", "Glithero R.J.", "Grafham D.V.", "Grant M.", "Gribble S.", "Griffiths C.", "Griffiths M.", "Hall R.", "Halls K.S.", "Hammond S.", "Harley J.L.", "Hart E.A.", "Heath P.D.", "Heathcott R.", "Holmes S.J.", "Howden P.J.", "Howe K.L.", "Howell G.R.", "Huckle E.", "Humphray S.J.", "Humphries M.D.", "Hunt A.R.", "Johnson C.M.", "Joy A.A.", "Kay M.", "Keenan S.J.", "Kimberley A.M.", "King A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.R.", "Lloyd D.M.", "Loveland J.E.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Maslen G.L.", "Matthews L.", "McCann O.T.", "McLaren S.J.", "McLay K.", "McMurray A.", "Moore M.J.", "Mullikin J.C.", "Niblett D.", "Nickerson T.", "Novik K.L.", "Oliver K.", "Overton-Larty E.K.", "Parker A.", "Patel R.", "Pearce A.V.", "Peck A.I.", "Phillimore B.", "Phillips S.", "Plumb R.W.", "Porter K.M.", "Ramsey Y.", "Ranby S.A.", "Rice C.M.", "Ross M.T.", "Searle S.M.", "Sehra H.K.", "Sheridan E.", "Skuce C.D.", "Smith S.", "Smith M.", "Spraggon L.", "Squares S.L.", "Steward C.A.", "Sycamore N.", "Tamlyn-Hall G.", "Tester J.", "Theaker A.J.", "Thomas D.W.", "Thorpe A.", "Tracey A.", "Tromans A.", "Tubby B.", "Wall M.", "Wallis J.M.", "West A.P.", "White S.S.", "Whitehead S.L.", "Whittaker H.", "Wild A.", "Willey D.J.", "Wilmer T.E.", "Wood J.M.", "Wray P.W.", "Wyatt J.C.", "Young L.", "Younger R.M.", "Bentley D.R.", "Coulson A.", "Durbin R.", "Hubbard T.", "Sulston J.E.", "Dunham I.", "Rogers J.", "Beck S."], "citationCrossReferences": [{"database": "PubMed", "id": "14574404"}, {"database": "DOI", "id": "10.1038/nature02055"}], "title": "The DNA sequence and analysis of human chromosome 6.", "publicationDate": "2003", "journal": "Nature", "firstPage": "805", "lastPage": "811", "volume": "425"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519221.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519221.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519221.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL031058", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "KF458095", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000713924.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519221.1"}, {"key": "GeneId", "value": "ENSG00000096696.17"}]}, {"database": "HGNC", "id": "HGNC:3052", "properties": [{"key": "GeneName", "value": "DSP"}]}, {"database": "OpenTargets", "id": "ENSG00000096696", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000154843", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 6"}]}], "sequence": {"value": "MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYWN", "length": 58, "molWeight": 6386, "crc64": "EFBEBEC73A0382C8", "md5": "92D86D1DD276000B3D9799FC4425608D"}, "extraAttributes": {"uniParcId": "UPI0032D0545A"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MKF7", "uniProtkbId": "A0AA96MKF7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50062.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50062.1"}], "value": "Collagen alpha-2(IV) chain-like protein"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 101, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 129, "modifier": "EXACT"}, "end": {"value": 276, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 54, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 81, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 91, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 139, "modifier": "EXACT"}, "end": {"value": 197, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 205, "modifier": "EXACT"}, "end": {"value": 218, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50062.1"}], "id": "KW-0176", "category": "Domain", "name": "Collagen"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50062.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460139", "properties": [{"key": "ProteinId", "value": "WNS50062.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005581", "properties": [{"key": "GoTerm", "value": "C:collagen trimer"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR008160", "properties": [{"key": "EntryName", "value": "Collagen"}]}, {"database": "PANTHER", "id": "PTHR24637", "properties": [{"key": "EntryName", "value": "COLLAGEN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01391", "properties": [{"key": "EntryName", "value": "Collagen"}, {"key": "MatchStatus", "value": "3"}]}], "sequence": {"value": "MGMGPGPGLGAWLLAEVMLASRSPCWLFTIVCLVTVCVCHTQATTYNYSPHYSTTRPTTRPTTRPTTRPATQYSSSYCPYRGCRGQQGPQGPKGGRGSSGLPGSMGSKGFCDPNLCFNWAVKAVHSQGGAVGQTGSKGDAGPPGLPGSDGSAGSPGSPGAMGPAGKDGVAGSSGSNGDPGAPGNSGPPGSMGPTGTVGNTGAKGEPGEKGEVGMKGDMGDPGLKGEPGVSGPAGQQGDNGPIGPPGFPGQDGTPGVNGTSGDPGRKGSPGDPGAPIVPLLGDADRCDEQNIGAFSFDIQSRQLQFCDGQNWRCVSLGSCP", "length": 320, "molWeight": 31622, "crc64": "45455AE42F3CAF56", "md5": "68AFFB282EDBE51AE700B3410C1C1AC9"}, "extraAttributes": {"countByFeatureType": {"Region": 2, "Compositional bias": 5}, "uniParcId": "UPI002B310FE2"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "C0HMC4", "uniProtkbId": "PRTA_PROMU", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Protobothrops mucrosquamatus", "commonName": "Taiwan habu", "synonyms": ["Trimeresurus mucrosquamatus"], "taxonId": 103944, "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Lepidosauria", "Squamata", "Bifurcata", "Unidentata", "Episquamata", "Toxicofera", "Serpentes", "Colubroidea", "Viperidae", "Crotalinae", "Protobothrops"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "Reference", "id": "Ref.1"}], "value": "Protocetin subunit alpha"}}, "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "Reference", "id": "Ref.1"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "Reference", "id": "Ref.1"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the snaclec family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 15, "modifier": "EXACT"}}, "description": "Protocetin subunit alpha", "featureId": "PRO_0000461055"}, {"type": "Non-terminal residue", "location": {"start": {"value": 15, "modifier": "EXACT"}, "end": {"value": 15, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000305"}]}], "keywords": [{"id": "KW-0903", "category": "Technical term", "name": "Direct protein sequencing"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-E842HMKF8NTO3", "citationType": "submission", "authors": ["Fan-Yu Z.", "Ren-Sheng J.", "Xiao-Qin Y.", "Ya-Nan L.", "Qi-Yun Z.", "Qian-Yun S."], "publicationDate": "JUN-2024", "submissionDatabase": "UniProtKB"}, "referencePositions": ["PROTEIN SEQUENCE", "SUBCELLULAR LOCATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "Reference", "id": "Ref.1"}], "value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}], "sequence": {"value": "DTPSDWSXFTRYTYK", "length": 15, "molWeight": 1878, "crc64": "FDB7DEA9DE41F98E", "md5": "25B74D299041448858231308BBD4FDA2"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI003390784F"}, "cluster_size": 1, "family": "Viperidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEW7", "uniProtkbId": "A0AB38ZEW7_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02813.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02813.1"}], "value": "Venom peptide Os8a"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 50, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044236393"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02813.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517563", "properties": [{"key": "ProteinId", "value": "WXI02813.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MKFLLFLLLVLVAVLVALISPANGCIERFGKCKQGDTCCEGSCFAFGQCF", "length": 50, "molWeight": 5406, "crc64": "98226598AE1E1618", "md5": "25C46DFFE952DF80DFB2E7A07EC1E04E"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BCE5D"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P9WEH0", "uniProtkbId": "FSOD_HUMFU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Humicola fuscoatra", "taxonId": 112175, "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Pezizomycotina", "Sordariomycetes", "Sordariomycetidae", "Sordariales", "Chaetomiaceae", "Humicola"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38654452"}], "value": "Cytochrome P450 monooxygenase fsoD"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}], "value": "1.-.-.-"}]}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38654452"}], "value": "Fuscoatroside biosynthesis cluster protein D"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38654452"}], "value": "fsoD"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}], "value": "Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the enfumafungin-type antibiotic, fuscoatroside (PubMed:38654452). Within the pathway, fsoD catalyzes the hydroxylation at position C2 of isomotiol to produce 2-alpha-hydroxy-isomotiol. FsoD may also hydroxylate the intermediates 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside at the same position C2 (PubMed:38654452). The fuscoatroside biosynthesis is initiated by the cyclization of 2,3(S)-oxidosqualene through FsoA's terpene cyclase (TC) domain, leading to the formation of the fernane skeleton isomotiol, harboring a fernane triterpene skeleton with a C8-C9 double bond. Subsequently, C2-alpha-hydroxylation mediated by fsoD results in the production of 2-alpha-hydroxy-isomotiol, which is further acetylated by fsoF. The glycosyltransferase (GT) domain of FsoA may convert isomotiol, 2-alpha-hydroxy-isomotiol, and the acetylated derivative of 2-alpha-hydroxy-isomotiol into their corresponding glycosides 3-O-(beta-D-glucopyranosyl)-isomotiol, 3-O-(beta-D-glucopyranosyl)-2-alpha-hydroxy-isomotiol, and 3-O-(beta-D-glucopyranosyl)-2-alpha-acetoxy-isomotiol, which then undergo oxidative cleavage under the action of fsoE to form s 2-deacetoxy-fuscoatroside, 2-deacetyl-fuscoatroside, and fuscoatroside, respectively. Although hydroxylation followed by acetylation of 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside by fsoD and fsoF could not be ruled out, this process is likely to occur with difficulty due to bulky steric hindrance caused by the presence of a glycan at C3 in these compounds. Interestingly, fsoE can also utilize the aglycones isomotiol and 2-alpha-hydroxy-isomotiol as substrates to generate 19-beta-hydroxy-isomotiol and 2-alpha,19-beta-dihydroxy-isomotiol, respectively. These reactions occur with lower efficiency. Finally, fsoE can further convert 2-alpha,19-beta-dihydroxy-isomotiol into 2-alpha-hydroxy-ismotiol-19-one and 2-alpha-hydroxy-ismotiol-19-one into 2-deacetyl-3-deglucopyranosyl-fuscoatroside (PubMed:38654452)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "isomotiol + reduced [NADPH--hemoprotein reductase] + O2 = 2alpha-hydroxyisomotiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:82727"}, {"database": "Rhea", "id": "RHEA-COMP:11964"}, {"database": "Rhea", "id": "RHEA-COMP:11965"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:15379"}, {"database": "ChEBI", "id": "CHEBI:57618"}, {"database": "ChEBI", "id": "CHEBI:58210"}, {"database": "ChEBI", "id": "CHEBI:232471"}, {"database": "ChEBI", "id": "CHEBI:232472"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:82728"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}]}]}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P04798"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}], "value": "Secondary metabolite biosynthesis; terpenoid biosynthesis"}], "commentType": "PATHWAY"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000255"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000255"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}], "value": "Fuscoatroside and some of its derivatives show interesting antifungal activity against Candida albicans and Aspergillus niger"}], "commentType": "BIOTECHNOLOGY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 547, "modifier": "EXACT"}}, "description": "Cytochrome P450 monooxygenase fsoD", "featureId": "PRO_0000461497"}, {"type": "Transmembrane", "location": {"start": {"value": 3, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Binding site", "location": {"start": {"value": 490, "modifier": "EXACT"}, "end": {"value": 490, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P04798"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38654452", "citationType": "journal article", "authors": ["Cao Z.Q.", "Wang G.Q.", "Luo R.", "Gao Y.H.", "Lv J.M.", "Qin S.Y.", "Chen G.D.", "Awakawa T.", "Bao X.F.", "Mei Q.H.", "Yao X.S.", "Hu D.", "Abe I.", "Gao H."], "citationCrossReferences": [{"database": "PubMed", "id": "38654452"}, {"database": "DOI", "id": "10.1021/jacs.4c02415"}], "title": "Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C-C Bond Cleavage.", "publicationDate": "2024", "journal": "J. Am. Chem. Soc.", "firstPage": "12723", "lastPage": "12733", "volume": "146"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [GENOMIC DNA]", "FUNCTION", "CATALYTIC ACTIVITY", "PATHWAY", "BIOTECHNOLOGY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR962264", "properties": [{"key": "ProteinId", "value": "XAF84279.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "UniPathway", "id": "UPA00213", "properties": [{"key": "RectionId", "value": "-"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0019748", "properties": [{"key": "GoTerm", "value": "P:secondary metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "CDD", "id": "cd11041", "properties": [{"key": "EntryName", "value": "CYP503A1-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "PANTHER", "id": "PTHR46206", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46206:SF1", "properties": [{"key": "EntryName", "value": "P450, PUTATIVE (EUROFUNG)-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYDITLAAVSIGLFFYVGARAVLKCLFPRQTSFPKHVPVVGVRDEMLSITRASLRQLTNGITTLLDGYSKHGQRNRPFVLYDPSAQPELLLPVQHIRWFSEQPDSKLSSHGVRQERHAVRYLHMGDQVELESTTRFIRYASNDRLNRHLENLQGLLHDEVRRSVDCVFGSQRQAQDDHWKEINLYGAMQDLVFPIMCRVFLGKELGESDEERGRVLTVFRRYLMAMGISTIFIGELPRLLKGVVARVVRIPLAYYRSQTLRMLVPLVRSQLSRTKHDEDDDDERGSDFIKHCANLSTKSTLSGTSSEAGPDLIAEWIMMLAGSLGFAGSSSTIIQATNLILDLVNTPPELLALQQLRHEAERTLQDDSNWTQAASFRQQKLADSAIRESLRLHPILIKGLTKEVVTPNGLELPDDENTTIPMGSWVGVPVLGIHQDERFYPQASEYRPFRFVEQAEAARTQAGGGSYEDAPEAAKPTTTYLGFGYGRHACPGRWFAVLMLKMILSYVLLHYDVESTGPAPKTRVLGDAALPPFRATIRVRKRKLGSE", "length": 547, "molWeight": 61616, "crc64": "9EA7D39EBC06DA84", "md5": "7B2DD5AD600A28724864D5FFAAD25C39"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 1, "COFACTOR": 1, "PATHWAY": 1, "SUBCELLULAR LOCATION": 1, "BIOTECHNOLOGY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI003369443C"}, "cluster_size": 2, "family": "Chaetomiaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NHW6", "uniProtkbId": "A0AA96NHW6_GYMSY", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 9, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Gymnema sylvestre", "commonName": "Gurmar", "synonyms": ["Periploca sylvestris"], "taxonId": 4068, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99868.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "asterids", "lamiids", "Gentianales", "Apocynaceae", "Asclepiadoideae", "Marsdenieae", "Gymnema"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99868.1"}], "value": "Disease resistance protein RPS5"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99868.1"}], "value": "RPS5"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008894"}], "value": "Belongs to the disease resistance NB-LRR family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 160, "modifier": "EXACT"}, "end": {"value": 377, "modifier": "EXACT"}}, "description": "NB-ARC", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00931"}]}, {"type": "Coiled coil", "location": {"start": {"value": 35, "modifier": "EXACT"}, "end": {"value": 62, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 597, "modifier": "EXACT"}, "end": {"value": 597, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99868.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022614"}], "id": "KW-0433", "category": "Domain", "name": "Leucine-rich repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022821"}], "id": "KW-0611", "category": "Biological process", "name": "Plant defense"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8JD0E4S7VLN46", "citationType": "submission", "authors": ["Kalariya K.A."], "title": "Transcriptomic revealing of plant pathogen interaction in Gymnema sylvestre.", "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99868.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR484770", "properties": [{"key": "ProteinId", "value": "WNT99868.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043531", "properties": [{"key": "GoTerm", "value": "F:ADP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006952", "properties": [{"key": "GoTerm", "value": "P:defense response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.10.8.430", "properties": [{"key": "EntryName", "value": "Helical domain of apoptotic protease-activating factors"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.10.10", "properties": [{"key": "EntryName", "value": "Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR042197", "properties": [{"key": "EntryName", "value": "Apaf_helical"}]}, {"database": "InterPro", "id": "IPR002182", "properties": [{"key": "EntryName", "value": "NB-ARC"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR050905", "properties": [{"key": "EntryName", "value": "Plant_NBS-LRR"}]}, {"database": "InterPro", "id": "IPR036388", "properties": [{"key": "EntryName", "value": "WH-like_DNA-bd_sf"}]}, {"database": "PANTHER", "id": "PTHR33463:SF136", "properties": [{"key": "EntryName", "value": "NB-ARC DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR33463", "properties": [{"key": "EntryName", "value": "NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00931", "properties": [{"key": "EntryName", "value": "NB-ARC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00364", "properties": [{"key": "EntryName", "value": "DISEASERSIST"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52047", "properties": [{"key": "EntryName", "value": "RNI-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVESAVIQGVGKLVEYSADAIKKQVRYLCCYSCNVQTLSDEVRELDIKRQSLQQRVDTDRNNLRDITPDVEAWLRNVEELKTRSDEILGDAEEVKRSCVCKWFPMLHYSLSRKALKTANDSVQLRNIEFREISTPIIAADIPPVPTTSIVSFKSRDSIEDKIVDALKDPSVYSIGIWGLGGVGKTVMAEKIEKRVRDEKLFEHVVMVVVSQQADIPKIQSHIAEGLGLPLSEDSPVSRQRKLHQRLMAEKGILIILDDLWERLNLEEFGIPSQSTHAGCKLILTSRNRDTLTFTGVQKFFQLQILNEEDSWRFFKVNIGINVDDDFPDDLVQIAMKVVRECKGLPLALKTVAYALKGKERFFWNNAVQELEKHVPDNIPGVIRDVYGSLQFSINALEGKEQKYLFLLCCLFPEDHYISIEELLRCRMGLGIFKELENLTEARDKVKAMLDILLTRSLLMKGDEKRESFNVRVHDVIRDVGIWIATEEGMEKRIFLIKHGLNKWPEVKENCNFISFLFSDYSIILPDTIVCPKLEFLRLDFVRRSTNYYVELPKNFLSGMGGLRVLEALHIQSLPQSIGQLNNLCTLSLQECKIFETI", "length": 597, "molWeight": 68387, "crc64": "F962B376ADFE1CEB", "md5": "3770D941F1C274161D356C666DB28E1A"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Coiled coil": 1, "Non-terminal residue": 1}, "uniParcId": "UPI002B2EF8DC"}, "cluster_size": 1, "family": "Apocynaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BH62", "uniProtkbId": "A0AAQ5BH62_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519236.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519236.1"}], "value": "Retinoid isomerohydrolase RPE65"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519236.1"}], "value": "RPE65"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BH62"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BH62"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519236.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519236.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519236.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519236.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL139413", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "KF454958", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000713939.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519236.1"}, {"key": "GeneId", "value": "ENSG00000116745.8"}]}, {"database": "HGNC", "id": "HGNC:10294", "properties": [{"key": "GeneName", "value": "RPE65"}]}, {"database": "OpenTargets", "id": "ENSG00000116745", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00950000182913", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}], "sequence": {"value": "MSIQVEHPAGGYKKLFETVEELSSPLTAHVTGSSALMLTYGQ", "length": 42, "molWeight": 4509, "crc64": "EB56AE6948C34662", "md5": "AA2B71395728881D74A8C647CD495C1A"}, "extraAttributes": {"uniParcId": "UPI0032D1BFD3"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAW9R1C7", "uniProtkbId": "A0AAW9R1C7_9CHRO", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Pannus brasiliensis CCIBt3594", "taxonId": 1427578, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MEG3439649.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001328733"}], "lineage": ["Bacteria", "Bacillati", "Cyanobacteriota", "Cyanophyceae", "Oscillatoriophycideae", "Chroococcales", "Microcystaceae", "Pannus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR005897"}], "value": "Protein PatA"}}}, "genes": [{"orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MEG3439649.1"}], "value": "V0288_21155"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR005897"}], "value": "Controls heterocyst pattern formation"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR005897"}], "value": "Cell septum", "id": "SL-0455"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR005897"}], "value": "By nitrogen starvation"}], "commentType": "INDUCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MEG3439649.1"}], "value": "The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}], "commentType": "CAUTION"}], "features": [{"type": "Domain", "location": {"start": {"value": 283, "modifier": "EXACT"}, "end": {"value": 399, "modifier": "EXACT"}}, "description": "Response regulatory", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50110"}]}, {"type": "Region", "location": {"start": {"value": 253, "modifier": "EXACT"}, "end": {"value": 273, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Modified residue", "location": {"start": {"value": 332, "modifier": "EXACT"}, "end": {"value": 332, "modifier": "EXACT"}}, "description": "4-aspartylphosphate", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00169"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR005897"}], "id": "KW-0364", "category": "Developmental stage", "name": "Heterocyst"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022553"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00169"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001328733"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR005897"}], "id": "KW-0902", "category": "Biological process", "name": "Two-component regulatory system"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-44EQRE9L1095V", "citationType": "submission", "authors": ["Machado M.", "Botero N.B.", "Andreote A.P.D.", "Feitosa A.M.T.", "Popin R.", "Sivonen K.", "Fiore M.F."], "title": "Genomic insights into the taxonomy and metabolism of the cyanobacterium Pannus brasiliensis CCIBt3594.", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MEG3439649.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001328733"}], "value": "CCIBt3594", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MEG3439649.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001328733"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "JBAFSM010000055", "properties": [{"key": "ProteinId", "value": "MEG3439649.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "RefSeq", "id": "WP_332867130.1", "properties": [{"key": "NucleotideSequenceId", "value": "NZ_JBAFSM010000055.1"}]}, {"database": "Proteomes", "id": "UP001328733", "properties": [{"key": "Component", "value": "Unassembled WGS sequence"}]}, {"database": "GO", "id": "GO:0030428", "properties": [{"key": "GoTerm", "value": "C:cell septum"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0043158", "properties": [{"key": "GoTerm", "value": "P:heterocyst development"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0000160", "properties": [{"key": "GoTerm", "value": "P:phosphorelay signal transduction system"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050595", "properties": [{"key": "EntryName", "value": "Bact_response_regulator"}]}, {"database": "InterPro", "id": "IPR011006", "properties": [{"key": "EntryName", "value": "CheY-like_superfamily"}]}, {"database": "InterPro", "id": "IPR025497", "properties": [{"key": "EntryName", "value": "PatA-like_N"}]}, {"database": "InterPro", "id": "IPR024186", "properties": [{"key": "EntryName", "value": "Sig_transdc_resp-reg_PatA"}]}, {"database": "InterPro", "id": "IPR001789", "properties": [{"key": "EntryName", "value": "Sig_transdc_resp-reg_receiver"}]}, {"database": "PANTHER", "id": "PTHR44591:SF3", "properties": [{"key": "EntryName", "value": "RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR44591", "properties": [{"key": "EntryName", "value": "STRESS RESPONSE REGULATOR PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14332", "properties": [{"key": "EntryName", "value": "DUF4388"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00072", "properties": [{"key": "EntryName", "value": "Response_reg"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF005897", "properties": [{"key": "EntryName", "value": "RR_PatA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00448", "properties": [{"key": "EntryName", "value": "REC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52172", "properties": [{"key": "EntryName", "value": "CheY-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50110", "properties": [{"key": "EntryName", "value": "RESPONSE_REGULATORY"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLNPSLTPTESSNGAGEVLERFAQARASGCLLVTERAVEWRFYFHQGQLTHATNSIDPFERLERHLRGLSAVNSQLSGAVRERARSLFANAPPNENSPQTADYRAILWLIQQKYLNATETRSLVAHLAGEVLQSYLLLDTIAHEFIPYSPVPLVHLDYRSFLQDCRAKLQGWQKLAPHIQSSYQRPYLIEQGGIVQSLREQQRDKLKKILIGFNFRQLAVLLNQDPLVLARNLHPLIVKGAIRLRAPQSPFDRLPTLSRSPDARASLSAPEESVPTRKVARTNLVCVDDSPAMLKAIKQFLSGHDVEIHTITDPLKALREIVRLEPKLILLDVGMPNLDGYRLCRLIRNHSLFKETPIIMVTGNTGMIDRAKAKVAGATDYLTKPFSQSDLEQMVSKYLVF", "length": 401, "molWeight": 45169, "crc64": "A019C8BDC32953CA", "md5": "75581E8D34AC5100FA8DC00E61ED37D2"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "INDUCTION": 1, "CAUTION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Modified residue": 1}, "uniParcId": "UPI002FCDD6AF"}, "cluster_size": 1, "family": "Microcystaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1B3", "uniProtkbId": "A0AAU7P1B3_MARVT", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maruca vitrata", "commonName": "Bean pod borer moth", "taxonId": 497515, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS26414.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Maruca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS26414.1"}], "value": "Cytochrome p450"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 376, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS26414.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-54EO10LSH7AVO", "citationType": "submission", "authors": ["Esmaeily M.", "kim Y."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS26414.1"}], "value": "4", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS26414.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP908383", "properties": [{"key": "ProteinId", "value": "XBS26414.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MLEVFDGDLLHQLQIPNHHHGVDKLVSSNESLFRIIVVHPLDVDCEVFHPEQYPGHVAQQWDGFVMLHAGLGEPRVDLLAVEPQGRPEGLLPICTATLPKLVITQQCYNSTRNCSRITVTGSGKPNGRLAQEENQRIRWCLHRHRYQRHDYSLCQCRHRLLRLRPEGGLPVRREQPVLPHGQGHFHLQLQTAAPLLRLFFALVNFRRLWIYQGTFVHGRYGVVLELATILLVCLSDLLHQFILNIRVEGQLVYSERHPRRHSLEAGDEEEDCLGCEVVVRPLSVNFFLSYIRFFHSGKSSIRIGCIIVVHQSSFFSLHQYMYHVWSDAISFFPVFHSIHHNILEELLYFLREQRNVQFCHELRKNQEEYKLQARPL", "length": 376, "molWeight": 43837, "crc64": "AB46FEC703A65FF5", "md5": "85D2FC8C4AD1547ECA005D936C446760"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D3568C"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMV5", "uniProtkbId": "A0AAU0QMV5_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56558.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56558.1"}], "value": "Odorant binding protein/PBP-general odorant binding protein"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043748237"}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56558.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 103, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56558.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56558.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56558.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970297", "properties": [{"key": "ProteinId", "value": "WPO56558.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "SMR", "id": "A0AAU0QMV5", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007608", "properties": [{"key": "GoTerm", "value": "P:sensory perception of smell"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "PANTHER", "id": "PTHR11857", "properties": [{"key": "EntryName", "value": "ODORANT BINDING PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKLILCVTCVSAVAILLASVNAGKEDEENMLRGVAEDCIKETGATDEDIKGVVNKQLPTTRSGKCFSFCVFHLFNCFSDTGDFQQEDFMTLVKMGIENDTLLE", "length": 103, "molWeight": 11333, "crc64": "316184DCDC5EBEE4", "md5": "3D9C5E4BE3E50A3DF5A051F30C3CE0A2"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI003084A048"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38Z7E9", "uniProtkbId": "A0AB38Z7E9_PAESU", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia suffruticosa", "commonName": "Tree peony", "synonyms": ["Paeonia moutan"], "taxonId": 45171, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20329.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20329.1"}], "value": "Beta-glucosidase 13-like"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010838"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003690"}], "value": "Belongs to the glycosyl hydrolase 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 28, "modifier": "EXACT"}, "end": {"value": 57, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 56, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-67NUCHPS7RPVN", "citationType": "submission", "authors": ["Zhang Y.", "Gai S."], "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20329.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR237914", "properties": [{"key": "ProteinId", "value": "WRI20329.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008422", "properties": [{"key": "GoTerm", "value": "F:beta-glucosidase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.20.20.80", "properties": [{"key": "EntryName", "value": "Glycosidases"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001360", "properties": [{"key": "EntryName", "value": "Glyco_hydro_1"}]}, {"database": "InterPro", "id": "IPR017853", "properties": [{"key": "EntryName", "value": "Glycoside_hydrolase_SF"}]}, {"database": "PANTHER", "id": "PTHR10353:SF154", "properties": [{"key": "EntryName", "value": "BETA-GLUCOSIDASE 9-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10353", "properties": [{"key": "EntryName", "value": "GLYCOSYL HYDROLASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00232", "properties": [{"key": "EntryName", "value": "Glyco_hydro_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00131", "properties": [{"key": "EntryName", "value": "GLHYDRLASE1"}]}, {"database": "SUPFAM", "id": "SSF51445", "properties": [{"key": "EntryName", "value": "(Trans)glycosidases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAESSFTSALSPAASQANYDPLTKKLRAGASYATTRPSEDVDTSDRPSEDVDRSDDFPTSFKFGASIFDAWRRPEPVARSDFPPSFKFGASSSALQTESYATEGRRGHCTWDEMLGDLPAVHSLILHFLVQDTTKGPHSINKQGVDFYNRLLDELNHNGIMPMVTLCHFDVPSALQKKYNGILGRQFVNDFNDYANLCFQLFGDKVKHWITFNEPSVYCESGYQYEMTGKDEPAIYPYLAAHHLLLAHATSVKTYRDCYQKQQNGKIGISLVTAWFLPYSGSCHDIVYLDPIVTGDYPFSMKSIVRDRLPQFSSEEKKMLEGSYDFIGVNYYTSRYTRALPFSPNDIPVSYAKDQYVEMLTEDKDGVPIGPQSEGMEFMYIAPKWLASILVNLKTKYNNPLIYITENGYPQLIQDKTMEEICDDQVRIDYIKDHLVSIRTALREGVNVDGYFSWTLMDNMEVKGYYYTIGFGLHHVDIPNDFERFPKKSAFWYRKFLSGKRAPLLSEPIIAKEPIMEPINAKATV", "length": 525, "molWeight": 59775, "crc64": "D2EDBCE99ADE9D9B", "md5": "92FC5376B3046D91FC2D948F6AAA1E11"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Region": 2, "Compositional bias": 2}, "uniParcId": "UPI00388BCE54"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7EBS4", "uniProtkbId": "A0AAU7EBS4_MOUSE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Mus musculus domesticus", "commonName": "western European house mouse", "taxonId": 10092, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "Truncated receptor-type tyrosine-protein phosphatase zeta transcript variant X1"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "3.1.3.48"}]}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}, {"evidenceCode": "ECO:0000313", "source": "MGI", "id": "MGI:97816"}], "value": "Ptprz1"}, "synonyms": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "DSD-1-PG"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "PTPbeta"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "Ptprz"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "Ptpz"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "PTPzeta"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "R-PTP-zeta"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "Rptpbeta"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "RPTPz"}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 51, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3I9S4IM5MILIV", "citationType": "journal article", "authors": ["Taki S.", "Boron W.F.", "Moss F.J."], "title": "Mouse RPTP-RPTP variants and expression.", "publicationDate": "2024", "journal": "Front. Physiol.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}], "value": "C57BL/6", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK22464.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP524784", "properties": [{"key": "ProteinId", "value": "XBK22464.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "AGR", "id": "MGI:97816", "properties": [{"key": "Description", "value": "-"}]}, {"database": "MGI", "id": "MGI:97816", "properties": [{"key": "GeneName", "value": "Ptprz1"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016787", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "SEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFI", "length": 61, "molWeight": 6689, "crc64": "0D193E82733D83DF", "md5": "936B96C48EE21E1C38FF0212DD97FD09"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D3D0FE"}, "cluster_size": 1, "family": "Muridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6MX04", "uniProtkbId": "A0AAU6MX04_ARGRE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Argyrosomus regius", "commonName": "Meagre", "taxonId": 172269, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WVX34104.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Neoteleostei", "Acanthomorphata", "Eupercaria", "Sciaenidae", "Argyrosomus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00014702"}], "value": "Interleukin-1 beta"}}, "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WVX34104.1"}], "value": "il1b"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004514"}], "value": "Cytoplasm, cytosol", "id": "SL-0091"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004371"}], "value": "Lysosome", "id": "SL-0158"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004550"}], "value": "Secreted, extracellular exosome", "id": "SL-0466"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010448"}], "value": "Belongs to the IL-1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WVX34104.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WVX34104.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022514"}], "id": "KW-0202", "category": "Molecular function", "name": "Cytokine"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023198"}], "id": "KW-0395", "category": "Biological process", "name": "Inflammatory response"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023228"}], "id": "KW-0458", "category": "Cellular component", "name": "Lysosome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023246"}], "id": "KW-0497", "category": "Molecular function", "name": "Mitogen"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022620"}], "id": "KW-0666", "category": "Molecular function", "name": "Pyrogen"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4NENQRPOO7E2", "citationType": "submission", "authors": ["Rocha A."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WVX34104.1"}], "value": "Head kidney", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WVX34104.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP338792", "properties": [{"key": "ProteinId", "value": "WVX34104.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005829", "properties": [{"key": "GoTerm", "value": "C:cytosol"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005764", "properties": [{"key": "GoTerm", "value": "C:lysosome"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005125", "properties": [{"key": "GoTerm", "value": "F:cytokine activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0071222", "properties": [{"key": "GoTerm", "value": "P:cellular response to lipopolysaccharide"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0019221", "properties": [{"key": "GoTerm", "value": "P:cytokine-mediated signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0001660", "properties": [{"key": "GoTerm", "value": "P:fever generation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006955", "properties": [{"key": "GoTerm", "value": "P:immune response"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0048246", "properties": [{"key": "GoTerm", "value": "P:macrophage chemotaxis"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042119", "properties": [{"key": "GoTerm", "value": "P:neutrophil activation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0051781", "properties": [{"key": "GoTerm", "value": "P:positive regulation of cell division"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0010628", "properties": [{"key": "GoTerm", "value": "P:positive regulation of gene expression"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:1901222", "properties": [{"key": "GoTerm", "value": "P:regulation of non-canonical NF-kappaB signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.80.10.50", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000975", "properties": [{"key": "EntryName", "value": "IL-1_fam"}]}, {"database": "InterPro", "id": "IPR008996", "properties": [{"key": "EntryName", "value": "IL1/FGF"}]}, {"database": "PANTHER", "id": "PTHR10078:SF30", "properties": [{"key": "EntryName", "value": "INTERLEUKIN-1 BETA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10078", "properties": [{"key": "EntryName", "value": "INTERLEUKIN-1 FAMILY MEMBER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00340", "properties": [{"key": "EntryName", "value": "IL1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50353", "properties": [{"key": "EntryName", "value": "Cytokine"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "SCHRDGDNEPALHLETVENPGNLASISSDSDMVRFLFYKQDTGLNLSTLVSVPYNDWYISTAKENNKPLGMCLENARRH", "length": 79, "molWeight": 8898, "crc64": "315E30FDAE921953", "md5": "1D91BE010289CC543D5B9C9E01CBBF04"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D3B1A0"}, "cluster_size": 1, "family": "Sciaenidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFJ5", "uniProtkbId": "A0AAU7VFJ5_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67480.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67480.1"}], "value": "Tudor domain protein 3"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67480.1"}], "value": "tudor3"}}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 203, "modifier": "EXACT"}, "end": {"value": 260, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 412, "modifier": "EXACT"}, "end": {"value": 472, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 606, "modifier": "EXACT"}, "end": {"value": 664, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Region", "location": {"start": {"value": 309, "modifier": "EXACT"}, "end": {"value": 357, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 741, "modifier": "EXACT"}, "end": {"value": 767, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 323, "modifier": "EXACT"}, "end": {"value": 342, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67480.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 767, "modifier": "EXACT"}, "end": {"value": 767, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67480.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67480.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67480.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750685", "properties": [{"key": "ProteinId", "value": "XBW67480.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "FunFam", "id": "2.30.30.140:FF:000018", "properties": [{"key": "EntryName", "value": "Serine/threonine-protein kinase 31"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Gene3D", "id": "2.40.50.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "InterPro", "id": "IPR035437", "properties": [{"key": "EntryName", "value": "SNase_OB-fold_sf"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR050621", "properties": [{"key": "EntryName", "value": "Tudor_domain_containing"}]}, {"database": "PANTHER", "id": "PTHR22948", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22948:SF72", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS50304", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "4"}]}], "sequence": {"value": "GSPCCAQYSEDNRWYRGRIISVDADNMKVHFIDYGNSETVARDLVRPLSQRFLAYPVRCLACSLSGVTPVDSSTWSEEAVAKFDDITAEAEAIQVTVVGLDRGRKTECGGAIYRVRLVVVADSVDVSRSLIDSGLAVSVPLINEVFAERDVLTGVKKSVIVSHVESPTDFYVQLLASEADLSSLTTGLQKFYSQPENGDLLEGEALGRACVAQFSDSCWYRSLVLTAGDDGLLVRYVDFGNSLKVAGEKVLVIDKQFLSLPAQAIHCSMDGVEEKCSEEVRKRFDEMTKSEVTCEFMGSHSDGRTIVRLSDKQGKQIDPTLKPSPASTSSSVTAPSSRAAVTPAAKPTRSYKRSESGFKKGQTLTAEVLYVDYDGTLYVQRPDDTATLEEIMALLATKYGEMGLREAEIDQNVAVGEPCVAKFTEDDSWYRAEVVGACGSDGLIPVRFVDYGNGESAEPFVVKNIEDSALTRPALALRCTLDGLPADNTDAINQLNDTVLGLSVTVTIASVTRAGILRVKISLEDGEDVASKLGFPAAEITETESGTTIPPQKPPSEEVEVYITHVVTPAEFYIQLSESTETLDELSESLCALYDSEACCRELAEPPGVGAMCCARFSEDAAWYRAVVTGVEGEMVDVQFMDYGNSDTVAMATEVKELSEEFTGKPALAYRCSLSGRDAATTGWSEEEITKFTELAGGGESAFTCTFLTTTTLDNTASHAVILTTSEGQLVNDMFGLASSLENSDEPSGYPAADAPSSSKACGTVKE", "length": 767, "molWeight": 82552, "crc64": "B5F133CD0465519A", "md5": "802CB7C3F263C23744B4513E02C8B994"}, "extraAttributes": {"countByFeatureType": {"Domain": 4, "Region": 2, "Compositional bias": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D38C2B"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7EB79", "uniProtkbId": "A0AAU7EB79_TERTR", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Terebratalia transversa", "commonName": "Transverse lampshell", "taxonId": 34513, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48607.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Brachiopoda", "Rhynchonelliformea", "Rhynchonellata", "Terebratellidina", "Laqueoidea", "Laqueidae", "Terebratalia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48607.1"}], "value": "Dickkopf5 protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48607.1"}], "value": "dkk5"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010842"}], "value": "Belongs to the dickkopf family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 28, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "Dickkopf N-terminal cysteine-rich", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF04706"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022687"}], "id": "KW-0879", "category": "Biological process", "name": "Wnt signaling pathway"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AKIT4T8HERMEG", "citationType": "submission", "authors": ["Vellutini B.C.", "Martin-Duran J.M.", "Borve A.", "Hejnol A."], "title": "Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48607.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP860514", "properties": [{"key": "ProteinId", "value": "XBK48607.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0039706", "properties": [{"key": "GoTerm", "value": "F:co-receptor binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0048019", "properties": [{"key": "GoTerm", "value": "F:receptor antagonist activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0090090", "properties": [{"key": "GoTerm", "value": "P:negative regulation of canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016055", "properties": [{"key": "GoTerm", "value": "P:Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.10.80.10", "properties": [{"key": "EntryName", "value": "Lipase, subunit A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006796", "properties": [{"key": "EntryName", "value": "Dickkopf_N"}]}, {"database": "InterPro", "id": "IPR039863", "properties": [{"key": "EntryName", "value": "DKK1-4"}]}, {"database": "PANTHER", "id": "PTHR12113:SF31", "properties": [{"key": "EntryName", "value": "DICKKOPF N-TERMINAL CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12113", "properties": [{"key": "EntryName", "value": "DICKKOPF3-LIKE 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF04706", "properties": [{"key": "EntryName", "value": "Dickkopf_N"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVSSQVLVSAIVFWIIQWRSILCSAYIWNFALSSTLNNKVDYDNFHPRNIRAFKDRISQHNAIDKQEICKTDKSCGKGKFCDRHYGFCDRKRQSGQYCRRDGQCEHGLQCMFGKCTKSLKHGTIGARCRHDKDCGASMCCARQHGERICKAKLKIHAKCYVPQGGLEYSLNEMCPCDRGLTCKPTLKQKDDSPSWRFWSTFDHMRCSPG", "length": 209, "molWeight": 24037, "crc64": "97E6A76398E3F653", "md5": "7B6000273F1D81033C7C9381324E73E4"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1}, "uniParcId": "UPI0035D2E5D1"}, "cluster_size": 1, "family": "Laqueidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P7X9", "uniProtkbId": "A0AAF0P7X9_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Tenuipotamon panxiense", "taxonId": 2841827, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59230.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00018074"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "value": "Autophagy-related protein 9"}}, "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59230.1"}], "value": "scaffold2009086"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "value": "Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004511"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "value": "Preautophagosomal structure membrane", "id": "SL-0221"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004511"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006185"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "value": "Belongs to the ATG9 family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 93, "modifier": "EXACT"}, "end": {"value": 115, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}]}, {"type": "Transmembrane", "location": {"start": {"value": 148, "modifier": "EXACT"}, "end": {"value": 165, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 35, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 11, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59230.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 184, "modifier": "EXACT"}, "end": {"value": 184, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59230.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023006"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "id": "KW-0072", "category": "Biological process", "name": "Autophagy"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023055"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "id": "KW-0445", "category": "Biological process", "name": "Lipid transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364027"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59230.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59230.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59230.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59230.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515353", "properties": [{"key": "ProteinId", "value": "WMS59230.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005776", "properties": [{"key": "GoTerm", "value": "C:autophagosome"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0034045", "properties": [{"key": "GoTerm", "value": "C:phagophore assembly site membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000422", "properties": [{"key": "GoTerm", "value": "P:autophagy of mitochondrion"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006869", "properties": [{"key": "GoTerm", "value": "P:lipid transport"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0034727", "properties": [{"key": "GoTerm", "value": "P:piecemeal microautophagy of the nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0034497", "properties": [{"key": "GoTerm", "value": "P:protein localization to phagophore assembly site"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0061709", "properties": [{"key": "GoTerm", "value": "P:reticulophagy"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR007241", "properties": [{"key": "EntryName", "value": "Autophagy-rel_prot_9"}]}, {"database": "PANTHER", "id": "PTHR13038", "properties": [{"key": "EntryName", "value": "APG9 AUTOPHAGY 9"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13038:SF10", "properties": [{"key": "EntryName", "value": "AUTOPHAGY-RELATED PROTEIN 9"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF04109", "properties": [{"key": "EntryName", "value": "ATG9"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "PFTGGLEERGDGGVQGSSSNSGCGGGGGAFMDEERDEDLSPDAHTSMVFHVVPKSSKSRWNHIEDLDSFFTRVYQYHQNHGLLCMMLQQAFELAQFIFIMVFTSFLVACVDYDILFRNKFPSDFNYNQTDKITLPDAIRTHDQCMEHFSWQLVVTILAASVFWLMRFGHACYTFFQFWEIKQFF", "length": 184, "molWeight": 21207, "crc64": "D934DDC9310B14FB", "md5": "C63F0AEAAB759053D72A5BA601650CB4"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 2, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2C15F6"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0W7", "uniProtkbId": "A0AA96S0W7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50057.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50057.1"}], "value": "Cadherin-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 9337, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041647876"}, {"type": "Transmembrane", "location": {"start": {"value": 9301, "modifier": "EXACT"}, "end": {"value": 9325, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 193, "modifier": "EXACT"}, "end": {"value": 291, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 286, "modifier": "EXACT"}, "end": {"value": 388, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 1251, "modifier": "EXACT"}, "end": {"value": 1355, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 1372, "modifier": "EXACT"}, "end": {"value": 1458, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 1459, "modifier": "EXACT"}, "end": {"value": 1558, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 1997, "modifier": "EXACT"}, "end": {"value": 2104, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 2105, "modifier": "EXACT"}, "end": {"value": 2198, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 2199, "modifier": "EXACT"}, "end": {"value": 2304, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 2306, "modifier": "EXACT"}, "end": {"value": 2407, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 2408, "modifier": "EXACT"}, "end": {"value": 2531, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 2822, "modifier": "EXACT"}, "end": {"value": 2902, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 2910, "modifier": "EXACT"}, "end": {"value": 3025, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 4345, "modifier": "EXACT"}, "end": {"value": 4453, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 4449, "modifier": "EXACT"}, "end": {"value": 4541, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 4550, "modifier": "EXACT"}, "end": {"value": 4669, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 4679, "modifier": "EXACT"}, "end": {"value": 4778, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 4773, "modifier": "EXACT"}, "end": {"value": 4877, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 4887, "modifier": "EXACT"}, "end": {"value": 4981, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 4982, "modifier": "EXACT"}, "end": {"value": 5090, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 5090, "modifier": "EXACT"}, "end": {"value": 5196, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 5197, "modifier": "EXACT"}, "end": {"value": 5310, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 5310, "modifier": "EXACT"}, "end": {"value": 5428, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 5429, "modifier": "EXACT"}, "end": {"value": 5550, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 5551, "modifier": "EXACT"}, "end": {"value": 5659, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 5659, "modifier": "EXACT"}, "end": {"value": 5787, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 5788, "modifier": "EXACT"}, "end": {"value": 5900, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 5909, "modifier": "EXACT"}, "end": {"value": 6008, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 6025, "modifier": "EXACT"}, "end": {"value": 6108, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 6231, "modifier": "EXACT"}, "end": {"value": 6311, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 6312, "modifier": "EXACT"}, "end": {"value": 6417, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 6418, "modifier": "EXACT"}, "end": {"value": 6538, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 7515, "modifier": "EXACT"}, "end": {"value": 7605, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 7613, "modifier": "EXACT"}, "end": {"value": 7723, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 8391, "modifier": "EXACT"}, "end": {"value": 8518, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 8519, "modifier": "EXACT"}, "end": {"value": 8625, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Domain", "location": {"start": {"value": 8772, "modifier": "EXACT"}, "end": {"value": 8871, "modifier": "EXACT"}}, "description": "Cadherin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50268"}]}, {"type": "Region", "location": {"start": {"value": 6051, "modifier": "EXACT"}, "end": {"value": 6075, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 6051, "modifier": "EXACT"}, "end": {"value": 6060, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022837"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00043"}], "id": "KW-0106", "category": "Ligand", "name": "Calcium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50057.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460134", "properties": [{"key": "ProteinId", "value": "WNS50057.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016342", "properties": [{"key": "GoTerm", "value": "C:catenin complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008013", "properties": [{"key": "GoTerm", "value": "F:beta-catenin binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045296", "properties": [{"key": "GoTerm", "value": "F:cadherin binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005509", "properties": [{"key": "GoTerm", "value": "F:calcium ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0016477", "properties": [{"key": "GoTerm", "value": "P:cell migration"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007156", "properties": [{"key": "GoTerm", "value": "P:homophilic cell adhesion via plasma membrane adhesion molecules"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11304", "properties": [{"key": "EntryName", "value": "Cadherin_repeat"}, {"key": "MatchStatus", "value": "31"}]}, {"database": "FunFam", "id": "2.60.40.60:FF:000033", "properties": [{"key": "EntryName", "value": "FAT atypical cadherin 1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "2.60.120.200", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "2.60.40.60", "properties": [{"key": "EntryName", "value": "Cadherins"}, {"key": "MatchStatus", "value": "34"}]}, {"database": "InterPro", "id": "IPR039808", "properties": [{"key": "EntryName", "value": "Cadherin"}]}, {"database": "InterPro", "id": "IPR002126", "properties": [{"key": "EntryName", "value": "Cadherin-like_dom"}]}, {"database": "InterPro", "id": "IPR015919", "properties": [{"key": "EntryName", "value": "Cadherin-like_sf"}]}, {"database": "InterPro", "id": "IPR020894", "properties": [{"key": "EntryName", "value": "Cadherin_CS"}]}, {"database": "InterPro", "id": "IPR013320", "properties": [{"key": "EntryName", "value": "ConA-like_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24027:SF438", "properties": [{"key": "EntryName", "value": "CADHERIN 23"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24027", "properties": [{"key": "EntryName", "value": "CADHERIN-23"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00028", "properties": [{"key": "EntryName", "value": "Cadherin"}, {"key": "MatchStatus", "value": "10"}]}, {"database": "Pfam", "id": "PF13385", "properties": [{"key": "EntryName", "value": "Laminin_G_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00205", "properties": [{"key": "EntryName", "value": "CADHERIN"}]}, {"database": "SMART", "id": "SM00112", "properties": [{"key": "EntryName", "value": "CA"}, {"key": "MatchStatus", "value": "35"}]}, {"database": "SUPFAM", "id": "SSF49313", "properties": [{"key": "EntryName", "value": "Cadherin-like"}, {"key": "MatchStatus", "value": "35"}]}, {"database": "SUPFAM", "id": "SSF49899", "properties": [{"key": "EntryName", "value": "Concanavalin A-like lectins/glucanases"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS00232", "properties": [{"key": "EntryName", "value": "CADHERIN_1"}, {"key": "MatchStatus", "value": "11"}]}, {"database": "PROSITE", "id": "PS50268", "properties": [{"key": "EntryName", "value": "CADHERIN_2"}, {"key": "MatchStatus", "value": "36"}]}], "sequence": {"value": "MLSSRLFGAFVILWAIAVLQNVHGQNLCSPPPCLDLSSGPANRESFNLRFSGIEDTNPQPLMIVTRAPPFGIYAEDDGLAAVFATIVEPGGGPVFNSTEIDIVSIGGSNLDPAFHGTNKTFSFNTMNESVLSTLMYIGGSGMLSSVNDFQMRTVQVHIMTTEGDLSNLVFADITIAYDNGDSPIFTNLPYMFDIDETASNGALVGTVMAQDDNNVTYSIVSDQFEIDDNGMITVKDNAAFDQEDSNPESYSLVVTATDGHLLSPRSATADVTIVINNVNDNAAQLQANPAIFFVPEDASQGFVIGSLEAFDPDNLTQDIQFLIKTFPPPSQFGLMPDGQIVIQVPLDYEVDEYYEFEVEIIDESGSDVIGTGTVQINVMNVDDERPAVTPISNNKAYIDLTVMPPETGTVLNDRFTIIDDSDFLTTGSAYLNRTDGLPYPNPYGCCDNISLNVFDICGLQNYANLFEGAVFNTAAAVPVGTPVYGADITSQTVGTPAVKAADAIVSDIMSITDNTFTFGGWVLYASTEAEYIFSIDENNNDHYFTLYATKNRLEFQYRRTFQLGEVEDLNGEDLDQQVRVIFNAPDNVPDGQSVKPSNHTLNDGRWHFIAIVCQGRNIMYYLDGQRYDPWSIIHRIPQQGKIQSFSTIDQPILQLPYDIYMPSSLLFGAIAGESNDAKHNLFNGKVSKLFFVHEALSMSILDCIASCNEFLLSEEPSNLNTSYNPATRVLTFKSDLPVAEYTEFLRTLRYESPVLAATDNARAVSIQVSDPIDAGSVTIVEIRAIGNIYRPVLDATGPDVEGLDYTVVIEEGEFDPVPIVSSGRVLTDRDAEALDPDQIDVDGLSQYVRVEFIRIEMEDPRFADAEERLSVDRAEDLTADVFANDTFVEITSNEVSNNRDMLTALNSVRYTITSTEPSSDNRTLIITVFDGFFENVPKTYTYISVQSVQDPVFVDLNGLGTPGVDRTVQFIEEDPPLQFPEEATISDEDTATVVSMTVELERVFDDGDESLDIGSFILPSGVTCSPSECNGTILQFTGVGSQATYTSILRSVHYLNRRRAADFPSLNDRFININVMNSDNQDANAVLTIDFFPISGRSIIDLDSPMKNFTTYFHENSTDKTIPIVGNVRVRDTSVLTLERVEVQLRRTVVGEAETITVNDTTAITDLAIEVNTGTDTVIFAIQEGSGQSAVDISIFVQAMQRLVYENFADEPDPRTRFIDFSIFPGQGIPDDFAITIINPILVNDNNPIFSSDSYFTSVAETAGLGHLVFTFSASDADKGIQGEVTYSSITANTSTIFSLVSETGEVRLLQALDFEIGATEFFMEVIATDGEGAQSLPATLFITVLNENDERPILSPNLISTNLTEGISATIVTFTVEDPDNLAGQTSTISIGGVEPSSEAGLFSIAGDATLVVSANLDYESSRNGVKVTVVASDGVNMGTALVMITVIDIDDEEPMFATDPIVFYLNEDNAVGMLVGTVSAADVDSDPLLVTYTLSGADSDGFYIATGGNIHVNFSASFEDNSKYEFVVAANDPGNNFGFANVIIMINDINNKHPILDLSASTDTTVNSITTTNYTEGAPAVKVITDPSFSDPDSVFIVRRILVRVDGGVANEDFLTLPASPNYAVGLQFGLQYMIAVDPVNSSDFSVVEFVLSNVLYENKAKEPSKDTQTIIFSIFDDLFFSNEANATVQITLVNDEPEVDLDIANSGNGFSTSYQEGGAGIGLTGDDFVLEDVDSMVTTMTISVSTAASSGNAERISVVSTDPSVTVSGSGTSQLTVMGAASPSVYKAILGSAIYEIDGQLEGVPARIISVSVSDGAATTEVFVNINFVITNALPIIHLDPPSRNRMITFQEEQGPLSSIAADATITDADDPLIVEMTVILQNPTPLERLFYNLSTVPASIDVTASDSSLRFNGSAPPSVYESILREIGYENNAEEFTGVPPPAQVIAIQIRDDRSGSSVVSEVTIALSPVNDHALLSDGPVSGAFAENSMDLMLAVTLTDDDQGVSQDITATIVSVFPSGVSAVTIGNQVTVSNGSTSPQQYSWTVTLSGPIDFEFHSSVVVQVSLVGPDGATVFENITYNILNLNDNTPTIEPIASPQFILEGIAVGSPTGIQIVASDEDGDQLDYDLTEGDEYLSLSDHSANFSLIVKSEIDRESIPGAMFPVVVVVRDGVFESTLSFIVFVDDVNDNSPMFEEPEYSFSIEEDVVVPVVIGVPTATDPDVNTGIPPIQYLISSEADAFGIEVNVTTGALTLTVEVDYEQTPSFLFLMRAIDSGSPQSTTTVNVTLVVSDVNDEAPTIDSPLVTSIVVKESNSADDIQIIATDPDSNSSLVYSIQPGIFPFSIGISGLIETTDGLDADIGSFVDNITVTVEDQFTASGYISITTKTYQILVDDVNDNPPVFTQPTYSFTLSEGMNFSTTAQVHATDADRGTDSAGNPNGYDQITFSLDATFDSAEPSISVVQEFFAVLPSGEIVVLKHIDREMNSVFVFRIKAEDSSSDPDWPSLTDFAIVTVNVSDINDNAPVADPSEYIGTVVEEAPSQTAVRTHVLARWDPFFLRTGVYHRQYAGQGIMLQSTSAMNVFICGYLELNDTHMSFNEVTYSSLQGIDCNSATATIIWLQRYTLELEETNVVDSFIKLADDTRSNILGAYSNPPTDDTASQYLNLDTTFLSTKWRVLERYITVREATYVVALNGLVGDQYKCNLKSGDGFQFGVEYNIFDIDSCNGGFTLGAISNTFDATSVYFLMGFNGPCMVTYGPLKDPPQGTLTTVDPLSVGGFLYVHMPNCASSQNCVFPSFSSGICDATLDRLVPAYIPINVFDADVDSLTLQFVSGDQGLFTISNDQSILTTGSIDRDSAGREKLNYLLVIEATDLSGKAVNYTVNVAVTDINDNLPTSDVGQCVGSVVENAANGSQVSNCSFSDSDYAANGDLTYSLIFPTGYPWDIIGSWFTIRTMQASPNNYGSIEVSGNINREFIFSELGVLYVDFTVVATDAGVSPQSGSVPIRVSIQEDNEFLPTISTSGNATYCEETDPVVITTVTLGDMDVDSHDIICASVSVIDAQDPNERGVSPSLPSQLSMSYFQNILVISGQLSPSQYENILSQVAYVSDADEFELPLWRTVEFCVADDRNGPFNFSDPSTLPCADLTFAKQNNLVSCAVAYVNLCELNDQPDANCSLIRHLPDIEEDSNAVENPGDEGTFVSEIVGSSLSDDDAGTSNIGIAIVELVSPQVGNWRYSIQHRFTYLWLDGGDSVEVELTVNSLCSGTIRIKSTQAYLNTPATLTLSPTVVIDVGQHLNVAHLSYFEIGTTTVTPTEIDFLRSEPIFDIMPPHITSPAIVSVLYNRDFARVSSAVSPSSAIVMGACGVLSFTSLPDEDTQGELLFVPWDQTAGSEGSSIDASSGFSSRTSAFGRDNCSIIADILPVDDAPTINVDQPGTIYREGGSPVSIAGNAAVDDVDNDMLQSIKVRISPEDGDCFNYQNDQDTLLYPASLPFSVSETRSQIGVSCVEYVFEGPLVLNEWEMFINMLTFTIGNLEPSGHVRSFAFSAPATATAIATTTVGVQTVDDNCPEIQVGSNVFTFLEEGSAISIVSSNFNLTDLDIPQDFLIQEVQVTVAYEDPAAIELTFASGSSVSVSDLGNGSYVLNGPATDADFTTVLRTMQFDLTTQEPLGVSAVITIRALDTRGGNVCFDQSSSITVVIEPINDNPAVLRLNNPSQNFSTSYTENGNPISVAMNVFISDSDEYPDMRSINYTVTVTLQGDCSDVDAFSEPGCSQAFTGPYQDIVSFINSIMFSSSAEAHASTARVIEFVLSDGSFERVSFTTVSVVPVNDEPVVDLSAADDSSGNAMKALPLDEPNLNYVKIVGDGGSAITDPDSPDINTISLQIREYDSSVVVIPRTLPDPALSWSDSLQFEDSMGTLQTVSPVSGITASFNVTTGILTLQGPAVHSDFETVLDSIVYVFEGFQVERNTRRIEVIACEAACSSPVESWINLMGVNHPPSVDCNGNAAGSGNSFLYSSASPGLFVCPGLTITEIDEGDGHLINRAIISIEGPLPTCSSLDVSLATHSAISQFEQYSGNTTVFELQSSPEGLLTSTFSDILRRVRFVSSQTDPGATCTVTFTVYDDLEFIERGEPIHIVSVQNASLMRSIPIPLIFGEAGEAPLSNLDPLTNLSYAGYEVSDFEGDDLQYLRVSLTDTPGRNGDLITFPCRHPTEEDLTSYYRGCVSNGESTTSTGLVFDGTYLSDCQPDSNICDGLSVEIQCPVSNMKTYEFRYTGNASAIRYYNLLGCIGYQNVEDVNRTNTVYKPLSLTASDGKNVSRTTQTTVRIRRFIPQIIFPVVPTVEVYEDARPNETALCVLEILSADTVSGRPLTSIEYEIVNGNTDDTFYIDNRGYIFLFKPLDRETVPYYNVTVQATSGESSANTTIEIFVLDVNDNRPVTDPVFNANASEGRADEFVINIPATDADIGTNQELLYSIVGYGSDVFRIYNNGSVYTRRALDRDIQNMYTLVVIISDKGSPVHLQNYTILHVTVVPRFVFLRFNDTYTATVVEESTDLSVVQVFAFEDESMSTDQIFYTLVSATPDYVNASLGSLFALDAVTGELSLTESWDAETVDGNGNSITAINITIQASSTKTQPTIIPATTEIVISIQDINDVPPVITCPGAIVASENRSLVPPLHSFSASDGDVTPTAEFTFRLAFTSGAPVTISSDGTLSLSSELDYEMNREYVLSVCVDDSTTPPMNSDCCNVTLMVTNVDDEPVQFINTPYNLPIREDANDGDVVVVLVAVDGDDAPFDVVEYSTPNNDIPFEVNITTGELRVSNPTFIDESEDEGPICFLVVATSKPSGMSAQTNVCVTVELLNDNSPIFEPNNYTVACIREDVAVNDVVVTVTATDADGGIDGEFEYTIMEVNGSFSVNQNGEVLTIKNLDYEEVDSFTFAVVATETGNEPRNSDTAEVTICLVDLNDNAPTFPGAPFTTSVIESAGNGHLVFQFGHVDEDGTLENRMVEYSLDTLDTPFSISGDTLVVSDAASLDYDEGQRVFLLQIRATNAPHIADDQTLVTTFNLTVTLINTNDHVPMFQGPFDIHVCEERPAGEMVAQFSATDRDVGIFGNFTFSLMDPSIECTSDFPFRVLSNGLFEACSRIDYEIVQDTPYMASVVVSDGNLTDTRTVAINVEDLNDNGPYFLNPTFEANMREDESNGFVVYTINTADDDGPANRILSITSSNAFQTPFSLAGNEIVLANQDSIDFDTGPIRYVVNVTVENVGMGSLVICPSNETRSIQVSITINIEDVNEHSPVLPFPFEFRFHETNDKDNETLVECFTATDADAGTSGVVSFSATAQTTEAECSQDFPFMFQQHATMFNTACIYSCNTADFESDQNVFEFSVVATDGGNPSMSSNQSYTVRLIDVNDEPPVFGNTELSISIEEKHGPNTVINLIVSDADSALNDVLYLELDVEPKPSPFAIDNSTRTVYVSDASLLDNDLSRADTYSFVVTAVNPPCRSGHEDASLCLNDDDTLTSEILFTVSIIDCNDQPPEFVQNLYVATLNEDAQVNATVLELDSTDDDRASSNKQVTYSIGESTPFGINGDMLIVADSSLLDFDTQPMTYTFVVFAENSAIACPSDTALNTTATVVISLIDVNDNDPALVEPDCITISESMAGPVSVLSLVATDADSGANAELNFNFDILANNVPDAESFNIDGVTPLSHLNCSRNSPFSIDPVTGEVFLCGPLDRENITSFVYVATAQDNGLPTRTSNPVKVCFIIEDVNDNPPVFQDDSFSFELPENSTTGTEIYTFVVTDDDVGANMEISFSASTVDGSVVDMCTPELPFAVSNDGILTLCLLIDYETDATLYIFMIEASDGGNPSMTTTITVTVSITDFNDNAPVFVTDNTAEVEEESANAIVISIRATDGDGTEINSNVTYTILGSVPESQFSIDQPVTGGDATLRTAEALDREAISIYSIILSACDTGTPQLCGSQTLNVTVVDIDDNDPVFGECNYTYVEETGFSFDITYTDADIGANAMLNFTLITEPELSLTSDGQVSTSDGLDRDPGTGGQEQRQFSLSSIPLSGNGEVFTAACTVLLTDINDNFPMFTSGPTIEIIESANDGEKVDYGVTADDFDKGVNQEITFALVPDDSTIGAIIDIRPNGEIFLIDEASLLPPLSFINISSTDGGGLVTYGNFAIELTDSIPLWAFNDTSVNLDEINFRTLITEQPASDRDIEMNDIFTYSIKSALPYGEFTIAGNGSVYIESCCLDAEDNNIFTLVVEVGPDNITVSDQLTISIVVDDMNDNAPYISPSQLAVSLEETTGPDTIILTVTAIDIDSGNNSQLTYALSGNDSSLFQFDSSGNLRLASGANLDYERTTRYVLFVTASDNGTPSRISNTATVTITVTDVDDNPPMFSRGMYMVNVSEGLAEGETAITIVISDADTQPEHISFTLEFIRGDPVNDQFEIIRSGSNDTINGVLVYADIRRRLGSSNLDRDNADRMIVLRANASDQSDEPPATTQVVIFLTDIDDSTPLIDPRSSASQINENATELQFSNFRINDSDTAASSPIMSLNIRLVPNSAFEGQSFPLDGGYSDHPQLDILAGNHIGELIGFDTATYPLSGYANSMNVYRPTGTQIISNVFDPVTTSDVTLFTFFSTNSISPVRHVLSFTSANYSISVEITPTQLIIVPSDGIQVSTTLSAEIQTAVVESICAMSVTIVRSTQFDAWLYCSSGSAHVQTSLTSLALLNAAHLMVGSANAINTYGQMAVFPHLLTAADITSLIRGGEYFTLSSTESSITITENIFARSLRVTYNGDDNAESVAVMTNALNSVIYHNDISEPQKDARNIELMASDSAGFGPPSTLTITVSLIDDSNPEADLNGLNEPGLDFATTFREKSAPVLIVSRDARIYDKDSGDQLISMVELHIQGANSTQATPSDLLEFTAGFPPNIEFDNRGTGLAYLIPANASVRSLPAETFTEALLAVTYQYNGTYFQPLIKYLTVTVVDSQGRMNDPRSTVTFSLTLVNDPPTLLNFDVMTQFQEAVGRVNVLSANGQSIDDPDSTALSEARITLENRLDGADEFLEVNTMGVSGITVTSEGTSSKYTLIVSGQASFAAYLVILQTVVYVNNVRNPGNPFSDDRIISFEVKDDGDDFGTPSSASARHNVTISIETLDDLAVVYLDYPSRDYATQFKEDSACIPFVNLDTVDIIDVDGGVAEAARIVLRAADNDPGTVNSTMRADGGLWEYISHDGFTGVGTTADDVPEPGVFAIELTLFDNDNLKRFLREARYCNYVDEPVFAVRVVTVEVKDPMDSTRTTYVSAANISVVEANDIPVVNVSAQEEVAIRNRPTPIFSSESVELDDSDDPLFKFVKIYITNPQNSQEEETIVFDGNLPIGAVSVGPKSSDLMAYPNAYLFEVTFSADGVSKDSIVAVIQQIRYQNNATNVNEIVSRVVCLVVSDFQDESEPSCVNIDLSASNLFAPVFGNHSVTLDTITVQENQGRVLIDQQVATDNDTDSLASSITYSIFSVMSRTPTNSLEATTGLFEVDSEGMIFANTLNAEEYIRHTITVQAEDRGNPILSGFIVVSVMVGDVNDNAPSLQVDTAGVFSDNLSPGLTIAELTIVDPDVSSANSEIDTATLQISSNYMINSRNVFVLSDTTLEADGSVTSRIRNGEVLDREQIGDPATLVVSVRDAQNLEGSVTITFTITDIPDTAPSVLQRTVAVYATDGDVPRPTASIGPAILVSDGDVDPKVETVVIELTPHSSDSSLLLSSCGCQDNIFEICQLNVMSSIDLLPISTFFNNPTTQINQAGLCDSVDLIRADQHYGTVKRDVFPEDLSVSGFTFTFVADQNREGYALLFTQNQTAGVFQLSLWIRRFTVDVNYAYTTDAGVTGIDETFDVDSAVEYFSRPNREHHWALTVDNVNREIRLYYDCGLRGTHPMQGSLNVSPDADLYFGKDPRRTVASLSRGFEGDVTDLYFHPTALSTSDIGCLCSCGSERLVAPSDLPVSTTATLSSNDQVLTIETSGGLAAESMTELLRSVQYDNTVPNPTLGDRQITFTATDAETTVGVPFTATSSGTIRLVANDDALPVIDNNNLVSGGVDYSTTFQEGGDPVPVTSAGVRITRGSLVNPSITSLQITISNPSSTDSESLVYSPSESSNGNNVLTVSGHDSHAITFTGPGIATDFETAVRDVKYQLSSNNPDTTDRIVQFSLEDTNGGTATSLTFITINPINDAPSLAIAQNQVIKFTERGSPVNVIKNPAITDPDSVTLQSATVSFTSGNLDGDELGFGSLPSGIKGSYDNDSGVLLFNGTASLSSYISILESVTFSTTQAPILDDEFVVDDNARTVSVVVTDTSGDDSSSVEQMVHFLPINDPPTITINGETVATVQFVESNPPVDVFIAAGVTIVDPDNQQLSRTILDLINPQEQENQEFMTLTINNVRSSRLVLGLNSLENTVALIGSATYTNTAPEPTLVSRTVRITVFDSADNSVTLTITIKFQTLNDNNPQFSQPSYSFSVNENADVGAEVSTLSASDEDVMTGLPNFSYSLVNSSVPFRLDSSSNEATLVVNGTLNFEEVSQYTLLVTVVDEPSSNQPLTGTAVITVNISNVSEAPVVDLSAADSTTFDQSVHTRYAEGSGLKSVFTEVITISDQDIDENVGSATVQMTGIQNPGQESITINGLSSGTVDGISFQTTSGTTIVASGAADASTYIQLLYNVTYLNSVNNVGLRLTREVTVEIRDEAGLISNTATAVILIANAPIFEQATYEVSLEENEDTDYIAIVSASTGLDVQLAYLIETQYLSLFNVTDTGAVFMIAALDFEALGSPVNVEVYAVDTEEPPVSGTATIVITLENVNDIAPVVGYTGTVSISQPGPNSLFDSNLDLTDPDQLELESVIVTVSGPDSLNESPYIGLVCVDDSDVSVKLRQCGVTADSVQLLESLRVTDGSMLLTPGTNNLELENGNYAELTNNTELSYFISDNWQPFAFVTWIMLPADSSGYIVSFSSNDGSTRYFGVEYNSESLRLFVYFKRPNFAGLQAITRVVFQLSESNRLDDNKWHFLMVVYESRDVRVSVDGQPISSSVVTYTTVVEGSQLPLSHDVCGPADVEGFRFVVGARITAEGGVDKQLPGEYASTHLITGTVPTSLSVCVTTCSEDFAAEITVPGIEVGDFNVTTRTLRLYGAASVASYVQLLSNLVYTNRATSPNIDWFDIEAFDGLFSTNASIPVSVQSKRKRRSVAPRPAAPLSGSIITSGRITSKRQTIVEPAPERKPRMSAPLAAEAEAPKEETKAYWFFPLGVLSATAIVLALGVVAWTLRKKSSKEDGLQV", "length": 9337, "molWeight": 1006856, "crc64": "C1F9C33539BEAA58", "md5": "21D76F6A2CE24392C1DE26E0A0553709"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 36, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B2E12F0"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBP2", "uniProtkbId": "A0AAU6PBP2_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20543.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20543.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 277, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043929788"}, {"type": "Non-terminal residue", "location": {"start": {"value": 277, "modifier": "EXACT"}, "end": {"value": 277, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20543.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20543.1"}], "value": "U_LCTX_66_Cm11", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20543.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480812", "properties": [{"key": "ProteinId", "value": "WXB20543.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd20235", "properties": [{"key": "EntryName", "value": "PFM_spherulin-2a-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.170.15.10", "properties": [{"key": "EntryName", "value": "Proaerolysin, chain A, domain 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR004991", "properties": [{"key": "EntryName", "value": "Aerolysin-like"}]}, {"database": "Pfam", "id": "PF03318", "properties": [{"key": "EntryName", "value": "ETX_MTX2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56973", "properties": [{"key": "EntryName", "value": "Aerolisin/ETX pore-forming domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNYSYLLLLLPVLTRAHISVKVKTSLEGVTGVQFSGSDEQLISDKDREAFGLSDEMLKTAITQFLGARPTDVYLRDSELYKKYGWSEVTRILKPVSSSIGAVHSTPVIINTQQFTNNDTTEATFSAGISQTVEETFSHTWSTGGEFSLGQDISYSFEMAGVGLSGTTSISHTASWGEETTKSKTVTVGSSSGLEITLPPGRKSQVTLLATRGSMHVTVGFAASLNGDFVCNYANKHNGHHIFKNKLKYLLQQVHFPSLVYSHETIEIGFYSDVHIIV", "length": 277, "molWeight": 30300, "crc64": "36DBDDCEFE1F8923", "md5": "92F3645FB8C90F326674FF699C48460D"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D3D09A"}, "cluster_size": 4, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHA3", "uniProtkbId": "A0AAQ5BHA3_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519286.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519286.1"}], "value": "Endoglin"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519286.1"}], "value": "ENG"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 372, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042954948"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHA3"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHA3"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519286.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15164053", "citationType": "journal article", "authors": ["Humphray S.J.", "Oliver K.", "Hunt A.R.", "Plumb R.W.", "Loveland J.E.", "Howe K.L.", "Andrews T.D.", "Searle S.", "Hunt S.E.", "Scott C.E.", "Jones M.C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Ashwell R.I.", "Babbage A.K.", "Babbage S.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beasley H.", "Beasley O.", "Bird C.P.", "Bray-Allen S.", "Brown A.J.", "Brown J.Y.", "Burford D.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Chen Y.", "Clarke G.", "Clark S.Y.", "Clee C.M.", "Clegg S.", "Collier R.E.", "Corby N.", "Crosier M.", "Cummings A.T.", "Davies J.", "Dhami P.", "Dunn M.", "Dutta I.", "Dyer L.W.", "Earthrowl M.E.", "Faulkner L.", "Fleming C.J.", "Frankish A.", "Frankland J.A.", "French L.", "Fricker D.G.", "Garner P.", "Garnett J.", "Ghori J.", "Gilbert J.G.", "Glison C.", "Grafham D.V.", "Gribble S.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Guy J.", "Hall R.E.", "Hammond S.", "Harley J.L.", "Harrison E.S.", "Hart E.A.", "Heath P.D.", "Henderson C.D.", "Hopkins B.L.", "Howard P.J.", "Howden P.J.", "Huckle E.", "Johnson C.", "Johnson D.", "Joy A.A.", "Kay M.", "Keenan S.", "Kershaw J.K.", "Kimberley A.M.", "King A.", "Knights A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.", "Lloyd D.M.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "McLaren S.", "McLay K.E.", "McMurray A.", "Milne S.", "Nickerson T.", "Nisbett J.", "Nordsiek G.", "Pearce A.V.", "Peck A.I.", "Porter K.M.", "Pandian R.", "Pelan S.", "Phillimore B.", "Povey S.", "Ramsey Y.", "Rand V.", "Scharfe M.", "Sehra H.K.", "Shownkeen R.", "Sims S.K.", "Skuce C.D.", "Smith M.", "Steward C.A.", "Swarbreck D.", "Sycamore N.", "Tester J.", "Thorpe A.", "Tracey A.", "Tromans A.", "Thomas D.W.", "Wall M.", "Wallis J.M.", "West A.P.", "Whitehead S.L.", "Willey D.L.", "Williams S.A.", "Wilming L.", "Wray P.W.", "Young L.", "Ashurst J.L.", "Coulson A.", "Blocker H.", "Durbin R.", "Sulston J.E.", "Hubbard T.", "Jackson M.J.", "Bentley D.R.", "Beck S.", "Rogers J.", "Dunham I."], "citationCrossReferences": [{"database": "PubMed", "id": "15164053"}, {"database": "DOI", "id": "10.1038/nature02465"}], "title": "DNA sequence and analysis of human chromosome 9.", "publicationDate": "2004", "journal": "Nature", "firstPage": "369", "lastPage": "374", "volume": "429"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519286.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519286.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519286.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL157935", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AL162586", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHA3", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000713996.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519286.1"}, {"key": "GeneId", "value": "ENSG00000106991.15"}]}, {"database": "HGNC", "id": "HGNC:3349", "properties": [{"key": "GeneName", "value": "ENG"}]}, {"database": "OpenTargets", "id": "ENSG00000106991", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00530000063861", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 9"}]}, {"database": "PROSITE", "id": "PS51257", "properties": [{"key": "EntryName", "value": "PROKAR_LIPOPROTEIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTVSMAPCSASLPTIRPLENTPSRSFQRKTFVASSSQTHLKASWGRPGCSMPALWHPSWSYRWPALSHFMPPAAVVGCRPHPHRSRPLLPRTLVARSCSCP", "length": 372, "molWeight": 40368, "crc64": "EED355CFCCCD80CC", "md5": "A7794A090AD04F781932063C44325F60"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0032D1E347"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96RS75", "uniProtkbId": "A0AA96RS75_PLADU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Platynereis dumerilii", "commonName": "Dumeril's clam worm", "taxonId": 6359, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNR62020.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Errantia", "Phyllodocida", "Nereididae", "Platynereis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "value": "Elongation of very long chain fatty acids protein"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "value": "2.3.1.199"}]}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "value": "Very-long-chain 3-oxoacyl-CoA synthase"}}]}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:32727"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:16526"}, {"database": "ChEBI", "id": "CHEBI:57287"}, {"database": "ChEBI", "id": "CHEBI:57384"}, {"database": "ChEBI", "id": "CHEBI:90725"}, {"database": "ChEBI", "id": "CHEBI:90736"}], "ecNumber": "2.3.1.199", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "value": "Belongs to the ELO family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Transmembrane", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 84, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Transmembrane", "location": {"start": {"value": 143, "modifier": "EXACT"}, "end": {"value": 162, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Transmembrane", "location": {"start": {"value": 168, "modifier": "EXACT"}, "end": {"value": 191, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Transmembrane", "location": {"start": {"value": 212, "modifier": "EXACT"}, "end": {"value": 234, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Domain", "location": {"start": {"value": 654, "modifier": "EXACT"}, "end": {"value": 729, "modifier": "EXACT"}}, "description": "K Homology", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00322"}]}, {"type": "Region", "location": {"start": {"value": 286, "modifier": "EXACT"}, "end": {"value": 307, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 334, "modifier": "EXACT"}, "end": {"value": 397, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 407, "modifier": "EXACT"}, "end": {"value": 476, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 286, "modifier": "EXACT"}, "end": {"value": 301, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 378, "modifier": "EXACT"}, "end": {"value": 387, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023160"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0275", "category": "Biological process", "name": "Fatty acid biosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022832"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0276", "category": "Biological process", "name": "Fatty acid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022516"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0444", "category": "Biological process", "name": "Lipid biosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023098"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0443", "category": "Biological process", "name": "Lipid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00117"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-860OA2E7TJQLG", "citationType": "submission", "authors": ["Ramos-Llorens M."], "publicationDate": "MAR-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNR62020.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ731769", "properties": [{"key": "ProteinId", "value": "WNR62020.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0009922", "properties": [{"key": "GoTerm", "value": "F:fatty acid elongase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0034625", "properties": [{"key": "GoTerm", "value": "P:fatty acid elongation, monounsaturated fatty acid"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0034626", "properties": [{"key": "GoTerm", "value": "P:fatty acid elongation, polyunsaturated fatty acid"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0019367", "properties": [{"key": "GoTerm", "value": "P:fatty acid elongation, saturated fatty acid"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030148", "properties": [{"key": "GoTerm", "value": "P:sphingolipid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042761", "properties": [{"key": "GoTerm", "value": "P:very long-chain fatty acid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00105", "properties": [{"key": "EntryName", "value": "KH-I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.1370.10", "properties": [{"key": "EntryName", "value": "K Homology domain, type 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002076", "properties": [{"key": "EntryName", "value": "ELO_fam"}]}, {"database": "InterPro", "id": "IPR004087", "properties": [{"key": "EntryName", "value": "KH_dom"}]}, {"database": "InterPro", "id": "IPR004088", "properties": [{"key": "EntryName", "value": "KH_dom_type_1"}]}, {"database": "InterPro", "id": "IPR036612", "properties": [{"key": "EntryName", "value": "KH_dom_type_1_sf"}]}, {"database": "PANTHER", "id": "PTHR11157:SF12", "properties": [{"key": "EntryName", "value": "ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11157", "properties": [{"key": "EntryName", "value": "FATTY ACID ACYL TRANSFERASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01151", "properties": [{"key": "EntryName", "value": "ELO"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00013", "properties": [{"key": "EntryName", "value": "KH_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00322", "properties": [{"key": "EntryName", "value": "KH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54791", "properties": [{"key": "EntryName", "value": "Eukaryotic type KH-domain (KH-domain type I)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50084", "properties": [{"key": "EntryName", "value": "KH_TYPE_1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDVLKDTAIHLWDDYQSAFQDGDKRVEDWFMMDAYWKTWAGSVLYLLIVWIGPKLMENREPMKLRYPIVIYNVLIVLLNFYIFYELLVCTTKRGYSYSCQLVDRSDNPYEVRIAKALWWFYFSKCMEFMDTFFFILRKKNTQITLLHVYHHASVFPLCWIGVKWHPGGQVFFGALMNSWTHVVMYSYYGLASMGPKVQKYLWWKRYITKMQLTQFVAGMVHGAQSISLGCPFPLWIQWTLFFYVGSMQALFWNFYFQAYIKPKHKLTKAEYTSSHIANGYSSQNKQALANGSEDNNGQALANGSRDNKKDMAENWLTSPLKDQDQVTVNAEDYDQISDETDETPAPRPKRTRNPSATDMCSFDKDSTFDPTSAEAPKQKRGRGRPKSKKDDDQDDTNQQLYLIRQELDNSYGDIDRLKREMETLVKENKKLASLLQENNKEKEEMELDLELTRSSLLEKECDYAELLDQFSQHEERTSAAPKPQGLVLFDGITVALLDCLPDTIEWKHMQKSLKDLKPNNMDMCQPFDLVLLMIGAEEIQDALAFPVFSDLKMIVEEACKFSEIYCTTLPPNNKNRLQVDLLIHKMLGSQIANSTMIKLKFTGSRSVWVTGDEMTHRCIRLYKEAIAATVSIPNELKGTASAASATASDESEAFEVSAIVPLKQSLFGRIIGKGGNVVKKLTDQHKVRMSFGMWSEERKEDGEVISGVLVRGLTKNVKSVTEEIKKITNYE", "length": 731, "molWeight": 84116, "crc64": "4A3EEAB3750B15A3", "md5": "D675AE387D3B0293BDB327C2B7146E90"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 5, "Domain": 1, "Region": 2, "Coiled coil": 1, "Compositional bias": 2}, "uniParcId": "UPI002B3204E7"}, "cluster_size": 1, "family": "Nereididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZLP7", "uniProtkbId": "A0AB38ZLP7_9TELE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenualosa ilisha", "commonName": "Hilsa shad", "taxonId": 373995, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAL74203.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Clupei", "Clupeiformes", "Clupeoidei", "Clupeidae", "Tenualosa"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAL74203.1"}], "value": "Luteinizing hormone"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAL74203.1"}], "value": "lh"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 2, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "Glycoprotein hormone subunit beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00007"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAL74203.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 40, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAL74203.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DOIEFQE65JEKT", "citationType": "submission", "authors": ["Pathan M.A.", "Dasgupta S.", "Tripathi G.", "Mitra P.", "Misra A.", "Pandey A."], "title": "Complete gene characterization of gonadotrophins in Tenualosa ilisha.", "publicationDate": "MAR-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAL74203.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ695492", "properties": [{"key": "ProteinId", "value": "XAL74203.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "Gene3D", "id": "2.10.90.10", "properties": [{"key": "EntryName", "value": "Cystine-knot cytokines"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR029034", "properties": [{"key": "EntryName", "value": "Cystine-knot_cytokine"}]}, {"database": "InterPro", "id": "IPR006208", "properties": [{"key": "EntryName", "value": "Glyco_hormone_CN"}]}, {"database": "Pfam", "id": "PF00007", "properties": [{"key": "EntryName", "value": "Cys_knot"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57501", "properties": [{"key": "EntryName", "value": "Cystine-knot cytokines"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "EPVYKSPFSMVYQHVCTYGNFRYETVRLPGCADGVDPFVT", "length": 40, "molWeight": 4574, "crc64": "EBC8DFF809F68825", "md5": "49418C3DA240BA80ABC7AA9B9505282C"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI00388C04B6"}, "cluster_size": 1, "family": "Clupeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0PBA6", "uniProtkbId": "A0AAF0PBA6_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Lobothelphusa thewanica", "taxonId": 3073734, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69313.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Lobothelphusa"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69313.1"}], "value": "XlCGF8.2DB-like gastrula zinc finger protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69313.1"}], "value": "scaffold1430345"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 53, "modifier": "EXACT"}, "end": {"value": 80, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 80, "modifier": "EXACT"}, "end": {"value": 107, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 108, "modifier": "EXACT"}, "end": {"value": 135, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 135, "modifier": "EXACT"}, "end": {"value": 162, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 169, "modifier": "EXACT"}, "end": {"value": 186, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69313.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 186, "modifier": "EXACT"}, "end": {"value": 186, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69313.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00042"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69313.1"}], "value": "S92", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69313.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69313.1"}], "value": "S92", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69313.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR517366", "properties": [{"key": "ProteinId", "value": "WMS69313.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000646", "properties": [{"key": "EntryName", "value": "Myeloid zinc finger 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000062", "properties": [{"key": "EntryName", "value": "RB-associated KRAB zinc finger protein-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:001009", "properties": [{"key": "EntryName", "value": "Zinc finger protein 26"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000038", "properties": [{"key": "EntryName", "value": "Zinc finger protein 624"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.160.60", "properties": [{"key": "EntryName", "value": "Classic Zinc Finger"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "InterPro", "id": "IPR036236", "properties": [{"key": "EntryName", "value": "Znf_C2H2_sf"}]}, {"database": "InterPro", "id": "IPR013087", "properties": [{"key": "EntryName", "value": "Znf_C2H2_type"}]}, {"database": "PANTHER", "id": "PTHR23226:SF416", "properties": [{"key": "EntryName", "value": "FI01424P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23226", "properties": [{"key": "EntryName", "value": "ZINC FINGER AND SCAN DOMAIN-CONTAINING"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00096", "properties": [{"key": "EntryName", "value": "zf-C2H2"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SMART", "id": "SM00355", "properties": [{"key": "EntryName", "value": "ZnF_C2H2"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "SUPFAM", "id": "SSF57667", "properties": [{"key": "EntryName", "value": "beta-beta-alpha zinc fingers"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS00028", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_1"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "PROSITE", "id": "PS50157", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_2"}, {"key": "MatchStatus", "value": "6"}]}], "sequence": {"value": "CEAVLMSNSRFIQHALSHIGVTVYRCNSCEKLFHSAAQLDRHAAVDHSERKRFECKECGKQFTRKGQFARHTDIHRGKKFMCEQCGKLFSQKGYLKVHKAIHSDLKLFKCDECGREFTQKSTLVHHFTVHSGKKFGCKDCGKVFSRKSYLSYHAKTHSSGTTSSDLKKFKCGECGRLFTHKGDLTQ", "length": 186, "molWeight": 21269, "crc64": "6058AAD697B0912E", "md5": "208F92E5C2D0F08D17648B41643B5396"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 6, "Non-terminal residue": 2}, "uniParcId": "UPI002B2F7B3D"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96UT42", "uniProtkbId": "A0AA96UT42_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29081.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29081.1"}], "value": "CREWS-C1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 187, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041722965"}, {"type": "Domain", "location": {"start": {"value": 74, "modifier": "EXACT"}, "end": {"value": 164, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29081.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651418", "properties": [{"key": "ProteinId", "value": "WNX29081.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLLFHLFLLFVILCSSAAQRVLLCDKPTDIRALMDANAEQLLLYTIGLMSDFVQMPTIKDVIKFTDCDADTAIRKASENISDGKQNVIVFITSDSSTVTEKAVQAAEEARSKGILLFAVGVGNDMDNTKLNELAGEATENKQFVFTYKDIDELYLRGYILRKGICKGGDKFELPTPDPCKKESVRRP", "length": 187, "molWeight": 20793, "crc64": "1462E5E547C02534", "md5": "6E72682F7021C60FE449F05451A95635"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B2C6C75"}, "cluster_size": 1, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJC4", "uniProtkbId": "A0AAU7LJC4_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28226.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28226.1"}], "value": "MADS31"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28226.1"}], "value": "MADS31"}}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 91, "modifier": "EXACT"}}, "description": "K-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51297"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28226.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28226.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400866", "properties": [{"key": "ProteinId", "value": "XBP28226.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR002487", "properties": [{"key": "EntryName", "value": "TF_Kbox"}]}, {"database": "Pfam", "id": "PF01486", "properties": [{"key": "EntryName", "value": "K-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51297", "properties": [{"key": "EntryName", "value": "K_BOX"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKIQPRIQSKFVFDRQMMGEELSGLSIKDLQNLENQLEMSLRGVRMKKDQILMDEIQELNRKQTTAAIARSSNDEGCHLVLSTKRNMVTNYASIKKMWYKSHRPINKRLRFETSYD", "length": 116, "molWeight": 13711, "crc64": "E93D0368D7122AD4", "md5": "77B668DF5C6238C0BCB79CF95D8E55D5"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D2E101"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2F9", "uniProtkbId": "A0AA96S2F9_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50043.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50043.1"}], "value": "WD repeat-containing protein 75-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004604"}], "value": "Nucleus, nucleolus", "id": "SL-0188"}}]}], "features": [{"type": "Repeat", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 94, "modifier": "EXACT"}}, "description": "WD", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00221"}]}, {"type": "Repeat", "location": {"start": {"value": 259, "modifier": "EXACT"}, "end": {"value": 300, "modifier": "EXACT"}}, "description": "WD", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00221"}]}, {"type": "Region", "location": {"start": {"value": 662, "modifier": "EXACT"}, "end": {"value": 682, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 738, "modifier": "EXACT"}, "end": {"value": 759, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 792, "modifier": "EXACT"}, "end": {"value": 848, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 743, "modifier": "EXACT"}, "end": {"value": 756, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 802, "modifier": "EXACT"}, "end": {"value": 822, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 823, "modifier": "EXACT"}, "end": {"value": 843, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022517"}], "id": "KW-0690", "category": "Biological process", "name": "Ribosome biogenesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022552"}], "id": "KW-0698", "category": "Biological process", "name": "rRNA processing"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022574"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00221"}], "id": "KW-0853", "category": "Domain", "name": "WD repeat"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50043.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460120", "properties": [{"key": "ProteinId", "value": "WNS50043.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005730", "properties": [{"key": "GoTerm", "value": "C:nucleolus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0032040", "properties": [{"key": "GoTerm", "value": "C:small-subunit processome"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:2000234", "properties": [{"key": "GoTerm", "value": "P:positive regulation of rRNA processing"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045943", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase I"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006364", "properties": [{"key": "GoTerm", "value": "P:rRNA processing"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.130.10.10", "properties": [{"key": "EntryName", "value": "YVTN repeat-like/Quinoprotein amine dehydrogenase"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR015943", "properties": [{"key": "EntryName", "value": "WD40/YVTN_repeat-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR036322", "properties": [{"key": "EntryName", "value": "WD40_repeat_dom_sf"}]}, {"database": "InterPro", "id": "IPR001680", "properties": [{"key": "EntryName", "value": "WD40_rpt"}]}, {"database": "InterPro", "id": "IPR053826", "properties": [{"key": "EntryName", "value": "WDR75"}]}, {"database": "PANTHER", "id": "PTHR44215", "properties": [{"key": "EntryName", "value": "WD REPEAT-CONTAINING PROTEIN 75"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR44215:SF1", "properties": [{"key": "EntryName", "value": "WD REPEAT-CONTAINING PROTEIN 75"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23869", "properties": [{"key": "EntryName", "value": "Beta-prop_WDR75_1st"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Pfam", "id": "PF23769", "properties": [{"key": "EntryName", "value": "Beta-prop_WDR75_2nd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00320", "properties": [{"key": "EntryName", "value": "WD40"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "SUPFAM", "id": "SSF69322", "properties": [{"key": "EntryName", "value": "Tricorn protease domain 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50978", "properties": [{"key": "EntryName", "value": "WD40 repeat-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50082", "properties": [{"key": "EntryName", "value": "WD_REPEATS_2"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MEQSVCKVQPVDCYSITDEKVVFSEDSKFVCLSCGESIRVYSVKTGQLVHTLAKHKSCVSGLALNPKNPYQLVSVCTDGELIIWDYEDGIALRVIELEQSVAGLQFAPRGLVGSPSKGFLACFVIARKVDSMTSEKEGKVAHAAVCVDWELLAGKGEDGGRGAGGDLLQRTKPVLHSLAKKCRVVFTHKGDCLVGFHRKDLLVYNFEQEHVVKHVSTYLVTCVAAHPSRDCVATGNKHGEVLLWYDFMDSKSPPVCSVLHWHAHQVHDVHFTPEGTNLLSVGMEGVMVIWKVESKKSTFRPHLGGPINTICSSPRGEYFALGMGDNTVNILSSYTNEVESTVGSLIRAHVNPGSTAGVLTGLVREPGRERVVLNASLGHLQFYDPVQGQLASELNVTGLNYVTQADKVPLVPTLVSFVQFSPSGDWMVTVESREDRMTTPELRMKFWKYSRENQRFELNTLVDPPHYSSLTGVAFSPGSEQMCATASHDGCFKTWLFHSNDQQDESSWFCSSESHYIREPAISCVFSRDGSILAVLYEKYITLWKPDACAAVKKVFAVPSVDEVFRFVCFQTEASTHYLVASTFHSLYVWNLTSCAVCWSVKAKVEQLVACPFLPCVAAFVRRNGTTNMSLFSPSDPTPLALFEDVCSTSVLGAVFLKSQSSSKPSSSELLSKTSDSSSDCNSFDGRSWYKTCTLYFMTQDQELYRIGLQTDDDEEKSLQLKYHRDSEGQNVYEQIFGLHSGPSPAASSSPQRAPAGLPDSKLSKIFSGPPHTLPPMSMLCSVFLRALHGQDLQGDGPQVGGEDEESVEVDSEELSSSEEEGEVLHTKDETQGLGEAQERMEDSEFTSKVSFDKSTTLTKENIGDFMWLTDVFKQMK", "length": 877, "molWeight": 96772, "crc64": "335AC708DE586D66", "md5": "5958B4766CEE626C0CA070617C7F8D1F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Repeat": 2, "Region": 3, "Compositional bias": 3}, "uniParcId": "UPI002B2DF754"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7YDW8", "uniProtkbId": "A0AAU7YDW8_NIDPL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Nidirana pleuraden", "commonName": "Yunnan pond frog", "synonyms": ["Babina pleuraden"], "taxonId": 369511, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87681.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Ranoidea", "Ranidae", "Nidirana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87681.1"}], "value": "Amplexin 7"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 166, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043571622"}, {"type": "Non-terminal residue", "location": {"start": {"value": 166, "modifier": "EXACT"}, "end": {"value": 166, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87681.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "38891597", "citationType": "journal article", "authors": ["Zheng P.", "Gong Y.", "Wang B.", "Yu H.", "Huang S.", "Liao X.", "Jiang J.", "Ran J.", "Xie F."], "citationCrossReferences": [{"database": "PubMed", "id": "38891597"}], "title": "Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.", "publicationDate": "2024", "journal": "Animals (Basel)", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87681.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-E24AGF4876IHP", "citationType": "submission", "authors": ["Zheng P."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87681.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP583597", "properties": [{"key": "ProteinId", "value": "XBY87681.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR045860", "properties": [{"key": "EntryName", "value": "Snake_toxin-like_sf"}]}, {"database": "SUPFAM", "id": "SSF57302", "properties": [{"key": "EntryName", "value": "Snake toxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKAMITLLILGLPLIHGKDLECWKTVEFGCSHQVNIPIKCTKNETRCAIKRLSSYSHSEALQCWKTTAFHGMIQVKSKINCTKDETQCVIIRQSPCVHRYSSEGCATEERCQESSTDPLYRCCATDLCNVFNVADLLEGRSFKSEMDKEKALEDIVIVGGGAPEEV", "length": 166, "molWeight": 18564, "crc64": "FE767B800C1C7A60", "md5": "BE4654EF012C24CD9D78161C34ED1D60"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D2BBD1"}, "cluster_size": 2, "family": "Ranidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QJZ7", "uniProtkbId": "A0AAU0QJZ7_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56486.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56486.1"}], "value": "Odorant receptor"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 39, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 82, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56486.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56486.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56486.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970379", "properties": [{"key": "ProteinId", "value": "WPO56486.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MALCECQWIFIYIYSKCIFLIQIKWLSIYLHNFIFLAMAKSYKIVYYRPVYENLVSELREMWPRGEVSEEEDQIIGSALTQLNYVVQGSLLLFLNYYIFFSF", "length": 102, "molWeight": 12324, "crc64": "FBD9CDEB785304EF", "md5": "7509465CF6FCD58B808B0F3A8CE2B343"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2}, "uniParcId": "UPI003091ED12"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB32TAB8", "uniProtkbId": "A0AB32TAB8_DANRE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Danio rerio", "commonName": "Zebrafish", "synonyms": ["Brachydanio rerio"], "taxonId": 7955, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}, {"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072243.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Cypriniformes", "Danionidae", "Danioninae", "Danio"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072243.1"}], "value": "Ice nucleation protein isoform X1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072243.1"}, {"evidenceCode": "ECO:0000313", "source": "ZFIN", "id": "ZDB-GENE-030131-5362"}], "value": "si:ch1073-263o8.2"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 1373, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044230020"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AB32TAB8"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "23594743", "citationType": "journal article", "authoringGroup": ["Genome Reference Consortium Zebrafish"], "authors": ["Howe K.", "Clark M.D.", "Torroja C.F.", "Torrance J.", "Berthelot C.", "Muffato M.", "Collins J.E.", "Humphray S.", "McLaren K.", "Matthews L.", "McLaren S.", "Sealy I.", "Caccamo M.", "Churcher C.", "Scott C.", "Barrett J.C.", "Koch R.", "Rauch G.J.", "White S.", "Chow W.", "Kilian B.", "Quintais L.T.", "Guerra-Assuncao J.A.", "Zhou Y.", "Gu Y.", "Yen J.", "Vogel J.H.", "Eyre T.", "Redmond S.", "Banerjee R.", "Chi J.", "Fu B.", "Langley E.", "Maguire S.F.", "Laird G.K.", "Lloyd D.", "Kenyon E.", "Donaldson S.", "Sehra H.", "Almeida-King J.", "Loveland J.", "Trevanion S.", "Jones M.", "Quail M.", "Willey D.", "Hunt A.", "Burton J.", "Sims S.", "McLay K.", "Plumb B.", "Davis J.", "Clee C.", "Oliver K.", "Clark R.", "Riddle C.", "Elliot D.", "Eliott D.", "Threadgold G.", "Harden G.", "Ware D.", "Begum S.", "Mortimore B.", "Mortimer B.", "Kerry G.", "Heath P.", "Phillimore B.", "Tracey A.", "Corby N.", "Dunn M.", "Johnson C.", "Wood J.", "Clark S.", "Pelan S.", "Griffiths G.", "Smith M.", "Glithero R.", "Howden P.", "Barker N.", "Lloyd C.", "Stevens C.", "Harley J.", "Holt K.", "Panagiotidis G.", "Lovell J.", "Beasley H.", "Henderson C.", "Gordon D.", "Auger K.", "Wright D.", "Collins J.", "Raisen C.", "Dyer L.", "Leung K.", "Robertson L.", "Ambridge K.", "Leongamornlert D.", "McGuire S.", "Gilderthorp R.", "Griffiths C.", "Manthravadi D.", "Nichol S.", "Barker G.", "Whitehead S.", "Kay M.", "Brown J.", "Murnane C.", "Gray E.", "Humphries M.", "Sycamore N.", "Barker D.", "Saunders D.", "Wallis J.", "Babbage A.", "Hammond S.", "Mashreghi-Mohammadi M.", "Barr L.", "Martin S.", "Wray P.", "Ellington A.", "Matthews N.", "Ellwood M.", "Woodmansey R.", "Clark G.", "Cooper J.", "Cooper J.", "Tromans A.", "Grafham D.", "Skuce C.", "Pandian R.", "Andrews R.", "Harrison E.", "Kimberley A.", "Garnett J.", "Fosker N.", "Hall R.", "Garner P.", "Kelly D.", "Bird C.", "Palmer S.", "Gehring I.", "Berger A.", "Dooley C.M.", "Ersan-Urun Z.", "Eser C.", "Geiger H.", "Geisler M.", "Karotki L.", "Kirn A.", "Konantz J.", "Konantz M.", "Oberlander M.", "Rudolph-Geiger S.", "Teucke M.", "Lanz C.", "Raddatz G.", "Osoegawa K.", "Zhu B.", "Rapp A.", "Widaa S.", "Langford C.", "Yang F.", "Schuster S.C.", "Carter N.P.", "Harrow J.", "Ning Z.", "Herrero J.", "Searle S.M.", "Enright A.", "Geisler R.", "Plasterk R.H.", "Lee C.", "Westerfield M.", "de Jong P.J.", "Zon L.I.", "Postlethwait J.H.", "Nusslein-Volhard C.", "Hubbard T.J.", "Roest Crollius H.", "Rogers J.", "Stemple D.L."], "citationCrossReferences": [{"database": "PubMed", "id": "23594743"}, {"database": "DOI", "id": "10.1038/nature12111"}], "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "publicationDate": "2013", "journal": "Nature", "firstPage": "498", "lastPage": "503", "volume": "496"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FT6AD0HQEQTFJ", "citationType": "submission", "authoringGroup": ["RefSeq"], "publicationDate": "APR-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072243.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072243.1"}]}], "uniProtKBCrossReferences": [{"database": "RefSeq", "id": "XP_005173963.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_005173906.3"}]}, {"database": "RefSeq", "id": "XP_068072243.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_068216142.1"}]}, {"database": "GeneID", "id": "327151", "properties": [{"key": "Description", "value": "-"}]}, {"database": "KEGG", "id": "dre:327151", "properties": [{"key": "Description", "value": "-"}]}, {"database": "ZFIN", "id": "ZDB-GENE-030131-5362", "properties": [{"key": "GeneName", "value": "si:ch1073-263o8.2"}]}, {"database": "Proteomes", "id": "UP000000437", "properties": [{"key": "Component", "value": "Chromosome 21"}]}, {"database": "PANTHER", "id": "PTHR36916:SF3", "properties": [{"key": "EntryName", "value": "SI:DKEY-229D11.5"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR36916", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNHLDYFAKLFIFLLLRHYWVCYADTPARTHGVAHVVSWDDVPDSVFEDLLGDLQIDVLKENVHGNFSLEFTDANGNFSLYADAVETGSNVHGNLSLDADAESNSTLHGNLSLDTAAESNSTLNANFTLNNAAESNSTLHGNLSLDDATDRNNNFSLDAAVESNSTLNGTFTLDNAAESNSTLHGNLSLDDATDGHLNFSLDASAVSNSSLQDAVDSGSNVHGNLSLDADTESNSTLHGNFSFDTADGNRNFSLDAAAESNSTLQAVKSPGSAKVAVRSLEDVPDSVFADFFRDLQNGLSREILQGNFSLEFTDANGNFTLYADAVEPGSNIHGNITLDKSAESNSTLHGNISLNDAAESNLTLYGNVSLDDAAESNLTLHGNVSLDDTAESNSTLYGNFILDDAAEEFNSTLYDNFSLDDAAESNSTLYKNFSLNAAESNSTLHGNISLDAAEEFNSTLHGNFSLDDAESNSTLYSNFSLDDAESNSTLYGNVSLDAAAESSSTLYGNFTLDVADFNSTLHGNISLDAAETNSTLYGNFSLDDDAESNSTLYGNVSLDATESNSTLYGNVSLDAAAESNSTLHGNFSLDDTAESNSTLYGNVNLDAAAESSSTLYGNVTLDVADFNSTLHGNISLDAAESNSTLFGDFTLDDAEESNSTLYGNFSLDDDAESNSTLYGNVSLDATESNSTLYGNVSLDAAAESNSTLYGNFSLDDAAESNSTLYGNFSLNAEESNSTLHGNVSLDNTAESNSTLYGNVSLDAAEFNSTLQGNVSLDAAAESSSTLYGNVTLDVADFNSTLHGNASLDATESNSTLFGNFSLDDATESNSTLYGNVSLDAAESNSTLHGNVSLDAAEESNSTLYGNVSLDAAESNSTLFGDFTLDDAAEEFNSTLYGNFSLHDDAESNSTLYGNVSLDAAEELNSTLYGNFSLDDAAESNSTLYGNFSLDAESNSALYGNFTLDDDAAAESYSALFGDFTLDDAAEEFNSTLHGNFSLDDTAESNSTLYGNVNLDAAAKSNSTLQGNVSLDAAAESSSTLYGNVTLDVADFNSTLHGNISLDAAESNSTLFGDFTLDDAEESNSTLYGNFSLDDAAESNSTLYGNFSLNAAESNSTLHGNVSLDDTAESNSTLYGNVSLDDAAESNSTLYGNFSLDDAESNSALYGNFSLDDAESNSALYGNFSLDDAESNSTLYGNFTLDDAAAESNSTLFGDFTLDDAAEEFNSTLHGNFSLDDTESNSDLYGNFSLDDGAESNSTLYGNFSLKAAAESNSTLGGNFSLDDAATSNSTQHGNFSLVNSALKAVFDLLGVGNSKQSNQIPSVPGPNVPDKPDPYSVSAFHESSADVLVVYGDLSNVGNPKAVTNVSKVNGCS", "length": 1373, "molWeight": 144369, "crc64": "A22A31837281F383", "md5": "13B2E6E6CD41CA602FD71B79765F5076"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0003835F80"}, "cluster_size": 4, "family": "Danionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0MUJ9", "uniProtkbId": "A0AAU0MUJ9_UREUN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Urechis unicinctus", "commonName": "Fat innkeeper worm", "synonyms": ["Chinese penis fish"], "taxonId": 6432, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59940.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Echiura", "Xenopneusta", "Urechidae", "Urechis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59940.1"}], "value": "Heat shock protein family A member 12 variant X1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59940.1"}], "value": "HSPA12"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007381"}], "value": "Belongs to the heat shock protein 70 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59940.1"}], "id": "KW-0346", "category": "Biological process", "name": "Stress response"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FQL9M4QGPVUS3", "citationType": "submission", "authors": ["Liu D.D."], "publicationDate": "FEB-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59940.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OM803161", "properties": [{"key": "ProteinId", "value": "WOS59940.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0140662", "properties": [{"key": "GoTerm", "value": "F:ATP-dependent protein folding chaperone"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd10229", "properties": [{"key": "EntryName", "value": "ASKHA_NBD_HSP70_HSPA12"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR043129", "properties": [{"key": "EntryName", "value": "ATPase_NBD"}]}, {"database": "InterPro", "id": "IPR013126", "properties": [{"key": "EntryName", "value": "Hsp_70_fam"}]}, {"database": "PANTHER", "id": "PTHR14187", "properties": [{"key": "EntryName", "value": "ALPHA KINASE/ELONGATION FACTOR 2 KINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14187:SF5", "properties": [{"key": "EntryName", "value": "HEAT SHOCK 70 KDA PROTEIN 12A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00012", "properties": [{"key": "EntryName", "value": "HSP70"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53067", "properties": [{"key": "EntryName", "value": "Actin-like ATPase domain"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MASEVYDPSLDRHADDQYLMVAAIDFGTTFSGYAFSLRSSLHDIIVYKHWGSELGIQGYKTPTCVLTDKDGSFKHFGYEAENFFVGLADGEDREYSFFSKFKMVLHRIKKLNKATNITASNGHFRPAIQIFAMALEYLKNHLLEVVTKQLKSCPNTRRIRWVITVPAIWSDASKQFMREAAFEAGIMPTVDSNQLIIALEPEAASVWCRSLSVDNFLNTTTSASTMQPGAKYIVIDAGGGTLDCTAHELLEDGHVRELERASGGAFGGTKVDDTFVKLLNDVFTKDFISLCKADCPAVWLQLMSSFEQRKKGFRPDQSETTNIQLTYQLASKYQEFTGNKLKDALKTSNVSGVSVNNGMLRISCEKMKELFQPCIDGIISHVDQMLKNIKLEKIEYILMVGGFSESPVLQQAMLSAFRQRAKVLIPHEAGLSVIKGAVLFGHDPLSITTRISRRTYGIKCQRTFNSEIHSYRKMRTVNGVDKAVDIFDPIIVKGEEVEIGTVKTFTFRPSRPDQTGADILIYGTDREEIQYVTEEGVELLGHVFVELAGQGQDRCIQARIIFGGPEITVEARDLSCTESAAHRCSLQFLFE", "length": 591, "molWeight": 66081, "crc64": "8D7DDFB92D124785", "md5": "44CCEC4152BD8D874902700878ABD2F7"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0035D3CF71"}, "cluster_size": 1, "family": "Urechidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96YJR6", "uniProtkbId": "A0AA96YJR6_PARAW", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pardosa astrigera", "commonName": "Wolf spider", "taxonId": 317848, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA03679.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Araneae", "Araneomorphae", "Entelegynae", "Lycosoidea", "Lycosidae", "Pardosa"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA03679.1"}], "value": "NPC intracellular cholesterol transporter 2-like protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA03679.1"}], "value": "NPC2-4"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006370"}], "value": "Belongs to the NPC2 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 158, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041661433"}, {"type": "Domain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "MD-2-related lipid-recognition", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00737"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4814ODGAGOV0B", "citationType": "submission", "authors": ["Zhao M.", "Li R."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA03679.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR671211", "properties": [{"key": "ProteinId", "value": "WOA03679.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "FunFam", "id": "2.60.40.770:FF:000001", "properties": [{"key": "EntryName", "value": "NPC intracellular cholesterol transporter 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.770", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR014756", "properties": [{"key": "EntryName", "value": "Ig_E-set"}]}, {"database": "InterPro", "id": "IPR003172", "properties": [{"key": "EntryName", "value": "ML_dom"}]}, {"database": "Pfam", "id": "PF02221", "properties": [{"key": "EntryName", "value": "E1_DerP2_DerF2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00737", "properties": [{"key": "EntryName", "value": "ML"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81296", "properties": [{"key": "EntryName", "value": "E set domains"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGGFLLVLMFVSLFASMECDVMPFTACESGNPPITVSIDPCGESTYIKDIGCIFKQGTKVKVQAPFIAPFTSGSLETIASATFRGHEIPFPDSGSNACSYIVPSCPIMEGRMNILNYNFEILKYYPTGEMDVKFMIRDRRTKKVAACAKTTVIIVESN", "length": 158, "molWeight": 17320, "crc64": "61EB2AFDD2B26FD7", "md5": "5DD535A34FE2AF34F8FA06C1DAC4231E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B2D292A"}, "cluster_size": 1, "family": "Lycosidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAG2UWH7", "uniProtkbId": "A0AAG2UWH7_HUMAN", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518323.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518323.1"}], "value": "Heterogeneous nuclear ribonucleoprotein H1"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518323.1"}], "value": "HNRNPH1"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518323.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAG2UWH7"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAG2UWH7"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518323.1"}]}], "uniProtKBCrossReferences": [{"database": "PeptideAtlas", "id": "A0AAG2UWH7", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000710518.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518323.1"}, {"key": "GeneId", "value": "ENSG00000284254.4"}]}, {"database": "HGNC", "id": "HGNC:5041", "properties": [{"key": "GeneName", "value": "HNRNPH1"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Unplaced"}]}, {"database": "GO", "id": "GO:0003676", "properties": [{"key": "GoTerm", "value": "F:nucleic acid binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.30.70.330", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050666", "properties": [{"key": "EntryName", "value": "ESRP"}]}, {"database": "InterPro", "id": "IPR012677", "properties": [{"key": "EntryName", "value": "Nucleotide-bd_a/b_plait_sf"}]}, {"database": "InterPro", "id": "IPR035979", "properties": [{"key": "EntryName", "value": "RBD_domain_sf"}]}, {"database": "PANTHER", "id": "PTHR13976", "properties": [{"key": "EntryName", "value": "HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54928", "properties": [{"key": "EntryName", "value": "RNA-binding domain, RBD"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "XSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGILKSLRAVELKLELIMIHHESLWPCSGQVLMTDLGLVEGITALAEELALRG", "length": 132, "molWeight": 14755, "crc64": "A95D87B3E2B2B130", "md5": "218DBC03A9C04C2C8E3E0D62473E1467"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0026459FA8"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96KA98", "uniProtkbId": "A0AA96KA98_9BILA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pectinatella magnifica", "taxonId": 350071, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25266.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Bryozoa", "Phylactolaemata", "Pectinatellidae", "Pectinatella"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25266.1"}], "value": "Hypoxia-inducible factor 1"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 106, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 191, "modifier": "EXACT"}, "end": {"value": 242, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25266.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 314, "modifier": "EXACT"}, "end": {"value": 314, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25266.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25266.1"}], "value": "Pectin1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25266.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ355001", "properties": [{"key": "ProteinId", "value": "WNN25266.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001610", "properties": [{"key": "EntryName", "value": "PAC"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "InterPro", "id": "IPR013655", "properties": [{"key": "EntryName", "value": "PAS_fold_3"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08447", "properties": [{"key": "EntryName", "value": "PAS_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00086", "properties": [{"key": "EntryName", "value": "PAC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "HVASIVRIAITYLKLQRLTSSGLQISDRPVSLTALDGKFDHFYMKALDGFLMIISKNGEIIYATDNVVFHLGIAQVDMIGHSIFDLTHPCDHDDIRDLITDKRRHSIASGANSDTRPHYDFFVRMKSNYLSKANFSTFKSSSYRVVHCCGHTMPVNDNDLLPCVVLTGQLIPHPSICDLHLDSHTFVTHHNLDMTITYCDQQIYSLLGYKLEQLIGKSLFLFHHALDGELLEKAFRTLFAKGQVLTGPYRFMAYGGGYCWLNTQATLVHNSSAADKAQRIICVNNVISNIEEKDLVLSEVQLLPVADEAESRTC", "length": 314, "molWeight": 35278, "crc64": "EB2F4D1F0B237F44", "md5": "E9DCF02BA5CFA4A1A222BAB0B8AF10EF"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 2, "Non-terminal residue": 2}, "uniParcId": "UPI002B31299C"}, "cluster_size": 1, "family": "Pectinatellidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96V0F2", "uniProtkbId": "A0AA96V0F2_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29086.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29086.1"}], "value": "VWACP-3"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 465, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041686235"}, {"type": "Domain", "location": {"start": {"value": 68, "modifier": "EXACT"}, "end": {"value": 244, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29086.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651423", "properties": [{"key": "ProteinId", "value": "WNX29086.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF87", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA-1(VI) CHAIN-LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLAILALPALLLTQLVVAHPHDDLSLRDLETLYELLAEEKRMIEEEPREMSNRVKEGFEEHCKQAPLELGLIIDSSVSINPTDYKKGLTFLAEYLDNYVISQDAVRVAAVTFGEGVYTQDGFNLTQYTSKEPLIQKVKTLPFRHGRSTDTGYALAHMRDVQLNNGITRKGVPKMVMVLTDGNSQKGAYTKAEALKVKAANITVMVVGVGNVKHSELVNIAGGVEKNVIKVTSYDKLGEEIRDKLKFASCTLVPKPTTPTTTTTTTTTTTMPAQEPCGKDFPTDINFIFSPSALGLEDTQYATRFISHVNKHEKLQEGTQYGLVTGDCPTDEGFTLKEYRKITDLDARLSYYDRNKIPELVEFAYSERFSAYNGGQDGATKVAVIFLNSAKVDTDRLITIIQQMVDDDVRVYISTRDTDTRDQWVSRLPREVTFLTPDPNSPQQHALEFVSLLCTPVVMGNNAART", "length": 465, "molWeight": 51777, "crc64": "D3261AC295197E40", "md5": "2F7037AC3883D41693B96C94469E7A7D"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B2EA153"}, "cluster_size": 1, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMX0", "uniProtkbId": "A0AAU0QMX0_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56565.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56565.1"}], "value": "Odorant binding protein/PBP-general odorant binding protein"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008098"}], "value": "Belongs to the PBP/GOBP family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043838019"}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56565.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56565.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56565.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970304", "properties": [{"key": "ProteinId", "value": "WPO56565.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007608", "properties": [{"key": "GoTerm", "value": "P:sensory perception of smell"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "PANTHER", "id": "PTHR11857:SF43", "properties": [{"key": "EntryName", "value": "GEO07291P1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11857", "properties": [{"key": "EntryName", "value": "ODORANT BINDING PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00708", "properties": [{"key": "EntryName", "value": "PhBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51257", "properties": [{"key": "EntryName", "value": "PROKAR_LIPOPROTEIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MHKIAIVCLSVFAACSICVASPNASLGPQILMAALDCMKAHPISISDILAIKNTLKIPDTKNANCFLACVLKRIGLLNDEGKFDTEKVYASVPLVFSNKDDDLAHKSKRVVDACTSVNTDSVSDGNKGCERARLAFNCLVQNAPKFGLSFKL", "length": 152, "molWeight": 16317, "crc64": "709DA4B935F86130", "md5": "979DF00D6EC41F6EAAAF7ED9864AA623"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0030854F1E"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LKL5", "uniProtkbId": "A0AAU7LKL5_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28244.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28244.1"}], "value": "MADS49"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28244.1"}], "value": "MADS49"}}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 43, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 115, "modifier": "EXACT"}, "end": {"value": 133, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 281, "modifier": "EXACT"}, "end": {"value": 305, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 338, "modifier": "EXACT"}, "end": {"value": 361, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 55, "modifier": "EXACT"}, "end": {"value": 139, "modifier": "EXACT"}}, "description": "K-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51297"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28244.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28244.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400884", "properties": [{"key": "ProteinId", "value": "XBP28244.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR002487", "properties": [{"key": "EntryName", "value": "TF_Kbox"}]}, {"database": "Pfam", "id": "PF01486", "properties": [{"key": "EntryName", "value": "K-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51297", "properties": [{"key": "EntryName", "value": "K_BOX"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVFLLVTLFNKEGLNRVSLLIRVMMGLTLLNGVPFGNIHYYNICFWSRFNKNRGYRSWYQEVTKLKFKYESLQRTQRHLLGEDLGPLSVKELQNLEKQLEAGLAQARQRKLTIPLMVNASVLITVAIDLWSLLKPRPLVHILVVIIQQKGLRYGDFISPYLFIFGVETFSRLILHAKNSTNLHGVKISRNVPIINRFIYIDDGDSISPYLFIFGAITFSRLLLLVENSLNLHGVKITRSVPTISHFLYADDIIIFYQANLIEIYCDILSGLDRKKIYLSLLFFYFDNVSLLLPVILYIWGIIYFYTKEKVFRRIIDNLIMKTKSWRSCMLSKASKATYIRSIILLLPVYSMSILKFLSLICDKGDSILRKLS", "length": 372, "molWeight": 43184, "crc64": "D23AC8E6357639C0", "md5": "11AD0B489AC626AFD0E3CD0C4757ABE3"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 4, "Domain": 1}, "uniParcId": "UPI0035D3247F"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEC9", "uniProtkbId": "A0AB38ZEC9_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71782.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71782.1"}], "value": "Venom POBP 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008098"}], "value": "Belongs to the PBP/GOBP family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044312201"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71782.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510857", "properties": [{"key": "ProteinId", "value": "WXH71782.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007608", "properties": [{"key": "GoTerm", "value": "P:sensory perception of smell"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "PANTHER", "id": "PTHR11857:SF43", "properties": [{"key": "EntryName", "value": "GEO07291P1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11857", "properties": [{"key": "EntryName", "value": "ODORANT BINDING PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00708", "properties": [{"key": "EntryName", "value": "PhBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLTKIFAGLLLVTMFSQTLSFDHLTYLRLKECQKEHKISENIINQVKMWKSLPNEGIYKCFLACWLDKLSVLTMDKYTNKKVADVLCDFNYDSEKSRNMAESFINYCEDKVQLTDKCQSAYEIYDCYATLMRENPGLDRHALYPNEKSSLTSL", "length": 153, "molWeight": 17885, "crc64": "34AE0FB75F7DE2C6", "md5": "EC1AF7267EE3D2CE87E896CA5B66BE17"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BD15E"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEI2", "uniProtkbId": "A0AB38ZEI2_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02678.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00066707"}], "value": "limulus clotting factor C"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00066707"}], "value": "3.4.21.84"}]}}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.", "ecNumber": "3.4.21.84", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00052079"}]}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 398, "modifier": "EXACT"}}, "description": "limulus clotting factor C", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044349999"}, {"type": "Domain", "location": {"start": {"value": 160, "modifier": "EXACT"}, "end": {"value": 390, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022820"}], "id": "KW-0353", "category": "Biological process", "name": "Hemolymph clotting"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022825"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022659"}], "id": "KW-0768", "category": "Domain", "name": "Sushi"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02678.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517428", "properties": [{"key": "ProteinId", "value": "WXI02678.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0042381", "properties": [{"key": "GoTerm", "value": "P:hemolymph coagulation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00190", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.40.10.10:FF:000120", "properties": [{"key": "EntryName", "value": "Putative serine protease"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001314", "properties": [{"key": "EntryName", "value": "Peptidase_S1A"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR018114", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24252", "properties": [{"key": "EntryName", "value": "ACROSIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24252:SF7", "properties": [{"key": "EntryName", "value": "HYALIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00722", "properties": [{"key": "EntryName", "value": "CHYMOTRYPSIN"}]}, {"database": "SMART", "id": "SM00020", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51257", "properties": [{"key": "EntryName", "value": "PROKAR_LIPOPROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00134", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRAFGVVICLGFIACSMANLIQVPSESKPIVLMPQTGPGVVETRFDLQACTGCKMVLTCAFQIYSCRLTKIAVYDGLEVTEHCPETNPYVFRNSWKSVMTVSFANAASRLGAFCQVVATRRYLDLPQMVVDSSEQGLLHNMPRSPNTCDCGWVNRSPRRIVRGKETEPNQLPYQAQLITADTKFGFCGGSIISVRHVLTAAHCTEPHKERQLAVRLGGHDILKRTSVIQEILIAKTYEHENYNTRTHENDIAILELVKDILFNTLVGPICLPNFQTVLNYGQTLKVSGWGRNENGKSTRVLMATNLNVMEPEVCETVYRQFVRGTQVCTYHPNTDSCQGDSGGPLAAHDPRTDRWYLAACVSFGTACTFSDPAVNTNIQAFLRWIQSITRGLECLLPS", "length": 398, "molWeight": 44235, "crc64": "EBB4462FA3AEF516", "md5": "7F3575619A26DF2E23C35D5EC93EF5F4"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388C1D43"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BIH3", "uniProtkbId": "A0AAQ5BIH3_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520437.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520437.1"}], "value": "Inositol polyphosphate-5-phosphatase J"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520437.1"}], "value": "INPP5J"}}], "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 43, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BIH3"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BIH3"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520437.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520437.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "18477386", "citationType": "journal article", "authors": ["Cole C.G.", "McCann O.T.", "Collins J.E.", "Oliver K.", "Willey D.", "Gribble S.M.", "Yang F.", "McLaren K.", "Rogers J.", "Ning Z.", "Beare D.M.", "Dunham I."], "citationCrossReferences": [{"database": "PubMed", "id": "18477386"}, {"database": "DOI", "id": "10.1186/gb-2008-9-5-r78"}], "title": "Finishing the finished human chromosome 22 sequence.", "publicationDate": "2008", "journal": "Genome Biol.", "firstPage": "R78", "lastPage": "R78", "volume": "9"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520437.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520437.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC005005", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000715268.1", "properties": [{"key": "ProteinId", "value": "ENSP00000520437.1"}, {"key": "GeneId", "value": "ENSG00000185133.15"}]}, {"database": "HGNC", "id": "HGNC:8956", "properties": [{"key": "GeneName", "value": "INPP5J"}]}, {"database": "OpenTargets", "id": "ENSG00000185133", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000156855", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 22"}]}], "sequence": {"value": "MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKPLTWPSQGLAHRVQGLAGA", "length": 54, "molWeight": 5452, "crc64": "3C8927665EBE452B", "md5": "0F1BA0CB165B507EAFC2AF73C21E72A7"}, "extraAttributes": {"countByFeatureType": {"Region": 1}, "uniParcId": "UPI0032C58D5E"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB32TAL0", "uniProtkbId": "A0AB32TAL0_DANRE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Danio rerio", "commonName": "Zebrafish", "synonyms": ["Brachydanio rerio"], "taxonId": 7955, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}, {"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072915.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Cypriniformes", "Danionidae", "Danioninae", "Danio"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072915.1"}], "value": "Uro-adherence factor A"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072915.1"}, {"evidenceCode": "ECO:0000313", "source": "ZFIN", "id": "ZDB-GENE-141212-268"}], "value": "si:ch73-160p18.3"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 2133, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044338765"}, {"type": "Region", "location": {"start": {"value": 150, "modifier": "EXACT"}, "end": {"value": 181, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 297, "modifier": "EXACT"}, "end": {"value": 321, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 370, "modifier": "EXACT"}, "end": {"value": 391, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 561, "modifier": "EXACT"}, "end": {"value": 626, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 638, "modifier": "EXACT"}, "end": {"value": 679, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 871, "modifier": "EXACT"}, "end": {"value": 896, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1973, "modifier": "EXACT"}, "end": {"value": 2006, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 150, "modifier": "EXACT"}, "end": {"value": 174, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 303, "modifier": "EXACT"}, "end": {"value": 314, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 375, "modifier": "EXACT"}, "end": {"value": 386, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 573, "modifier": "EXACT"}, "end": {"value": 584, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 609, "modifier": "EXACT"}, "end": {"value": 620, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 645, "modifier": "EXACT"}, "end": {"value": 656, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 663, "modifier": "EXACT"}, "end": {"value": 679, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 871, "modifier": "EXACT"}, "end": {"value": 890, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1988, "modifier": "EXACT"}, "end": {"value": 2006, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AB32TAL0"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "23594743", "citationType": "journal article", "authoringGroup": ["Genome Reference Consortium Zebrafish"], "authors": ["Howe K.", "Clark M.D.", "Torroja C.F.", "Torrance J.", "Berthelot C.", "Muffato M.", "Collins J.E.", "Humphray S.", "McLaren K.", "Matthews L.", "McLaren S.", "Sealy I.", "Caccamo M.", "Churcher C.", "Scott C.", "Barrett J.C.", "Koch R.", "Rauch G.J.", "White S.", "Chow W.", "Kilian B.", "Quintais L.T.", "Guerra-Assuncao J.A.", "Zhou Y.", "Gu Y.", "Yen J.", "Vogel J.H.", "Eyre T.", "Redmond S.", "Banerjee R.", "Chi J.", "Fu B.", "Langley E.", "Maguire S.F.", "Laird G.K.", "Lloyd D.", "Kenyon E.", "Donaldson S.", "Sehra H.", "Almeida-King J.", "Loveland J.", "Trevanion S.", "Jones M.", "Quail M.", "Willey D.", "Hunt A.", "Burton J.", "Sims S.", "McLay K.", "Plumb B.", "Davis J.", "Clee C.", "Oliver K.", "Clark R.", "Riddle C.", "Elliot D.", "Eliott D.", "Threadgold G.", "Harden G.", "Ware D.", "Begum S.", "Mortimore B.", "Mortimer B.", "Kerry G.", "Heath P.", "Phillimore B.", "Tracey A.", "Corby N.", "Dunn M.", "Johnson C.", "Wood J.", "Clark S.", "Pelan S.", "Griffiths G.", "Smith M.", "Glithero R.", "Howden P.", "Barker N.", "Lloyd C.", "Stevens C.", "Harley J.", "Holt K.", "Panagiotidis G.", "Lovell J.", "Beasley H.", "Henderson C.", "Gordon D.", "Auger K.", "Wright D.", "Collins J.", "Raisen C.", "Dyer L.", "Leung K.", "Robertson L.", "Ambridge K.", "Leongamornlert D.", "McGuire S.", "Gilderthorp R.", "Griffiths C.", "Manthravadi D.", "Nichol S.", "Barker G.", "Whitehead S.", "Kay M.", "Brown J.", "Murnane C.", "Gray E.", "Humphries M.", "Sycamore N.", "Barker D.", "Saunders D.", "Wallis J.", "Babbage A.", "Hammond S.", "Mashreghi-Mohammadi M.", "Barr L.", "Martin S.", "Wray P.", "Ellington A.", "Matthews N.", "Ellwood M.", "Woodmansey R.", "Clark G.", "Cooper J.", "Cooper J.", "Tromans A.", "Grafham D.", "Skuce C.", "Pandian R.", "Andrews R.", "Harrison E.", "Kimberley A.", "Garnett J.", "Fosker N.", "Hall R.", "Garner P.", "Kelly D.", "Bird C.", "Palmer S.", "Gehring I.", "Berger A.", "Dooley C.M.", "Ersan-Urun Z.", "Eser C.", "Geiger H.", "Geisler M.", "Karotki L.", "Kirn A.", "Konantz J.", "Konantz M.", "Oberlander M.", "Rudolph-Geiger S.", "Teucke M.", "Lanz C.", "Raddatz G.", "Osoegawa K.", "Zhu B.", "Rapp A.", "Widaa S.", "Langford C.", "Yang F.", "Schuster S.C.", "Carter N.P.", "Harrow J.", "Ning Z.", "Herrero J.", "Searle S.M.", "Enright A.", "Geisler R.", "Plasterk R.H.", "Lee C.", "Westerfield M.", "de Jong P.J.", "Zon L.I.", "Postlethwait J.H.", "Nusslein-Volhard C.", "Hubbard T.J.", "Roest Crollius H.", "Rogers J.", "Stemple D.L."], "citationCrossReferences": [{"database": "PubMed", "id": "23594743"}, {"database": "DOI", "id": "10.1038/nature12111"}], "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "publicationDate": "2013", "journal": "Nature", "firstPage": "498", "lastPage": "503", "volume": "496"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FT6AD0HQEQTFJ", "citationType": "submission", "authoringGroup": ["RefSeq"], "publicationDate": "APR-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072915.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068072915.1"}]}], "uniProtKBCrossReferences": [{"database": "RefSeq", "id": "XP_068072915.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_068216814.1"}]}, {"database": "KEGG", "id": "dre:100332020", "properties": [{"key": "Description", "value": "-"}]}, {"database": "ZFIN", "id": "ZDB-GENE-141212-268", "properties": [{"key": "GeneName", "value": "si:ch73-160p18.3"}]}, {"database": "Proteomes", "id": "UP000000437", "properties": [{"key": "Component", "value": "Chromosome 23"}]}, {"database": "PANTHER", "id": "PTHR37409:SF5", "properties": [{"key": "EntryName", "value": "CELL WALL PROTEIN AWA1-LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR37409", "properties": [{"key": "EntryName", "value": "RIKEN CDNA D130052B06 GENE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVICKCLVAVLLWCQLMFNGFTSPIGCPFNHDGVKRCDSKSEGGRTHSIMAKSNLALLLALKNASGLIIQRGIKGLPQTIPFSAEVSRPHITKESSAALAELTRKLRPSGCLSEEIDLSTKNVKQSGSGSLTLVSSPQPTEKLTASGSLTVVSNPQPTEKLTESGSLTVVSSPRPTEKLTESGSLTVALGPRPTEKLTESGSLTVALGPRPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVSSPRLTESGSLTVVLGPQPTEKVKESGSLTVVLGPQPTEKLTESGSLTVVSSPWPTEKLTESGSLTVVSSPRPTEKLTESGSLTVALGPRPTEKLTESGSLTVVSSPRPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSSPRPTEKLTESGSLTVVLGPQPTEKVKESGSLTVVLGPQPTEKLTESGSLTVVSSPWPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSNPRPTEKLTESGSLTVALGPRPTEKLTESGSLTVVSSPRPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSSPRPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSSPRPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSNPRPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVLGPQPTEKVTESGSLTVVLGPQPTEKLTESGSLTVVSSPRPTEKLTESGTLTVVLGPQPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVSSPRPTEKLTESGSLTVVLGPQPTEKVKESGSLTVVLGPQPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVLEPQPTEKLTESGSLTVVSSPRPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVLEPQPTEKLTESGSLTVVSSPRPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSNPQPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSNPQPTEKLTESGSLTCVSYPQPTEKLTESGSLTVVLGPQPTEKLTESGSLTVVSNLQPTEKLTESGSLTVKSSALSAACPVSVASSPLPTEKLNHSVSLTLSSPQPTEKLTESGSLTVVLQPQQTEKLTESGSLTVVLGPQQTEKLTESGSLTVVLGPQPTEKLAESGSLTVALGPQPTEKLTESGSLTVALGPQPSEKLAESGSLTVALGPQPTEKLTESGSLTMAVGPQPTEKLTESGSLTVALGPQPTEKLTESGSLTVALGPQPTEKLAESGSLTVALGPQPTEKLAESGSLTVALGPQPTEKLAESGSLTVALGPQPTEKLAESGSLTVVLGPQPTEKLTESGSLTVALGPQPTEKLAESGSLTVVLGPQPTEKLAESGSLTVALGPQPTEKLAESGSLTVALGPQPTEKLAESGSLTVALGPQPTEKLAESGSLTVALGPQPTEKLAESGSLTVALGPQPTEKLAESGSLTVVLGPQPTEKLAESGSLTVALGPQPTEKLTESGSLTVALGPQPTEKLAESGSLTVALGPQPTEKLTESGSLTVALGPQPTEKLTESGSLTVALGPQPTEKLTESGSLTVALGPQPTDKLTESGSLTVVLGPQPTEKLAESGSLTVALGPQPTEKLTESGSLTVALGPQPTEKLAESGSLTVALGPQPTEKLTESGSLTVALGPQPTEKLTESGSLTVALGPQPTEKLTESGSLTVALGPQPTDKLTESGSLTVALGPQPTGKLTESGTLTVVLGPQPTEKLAESGSLTVALGPQPTEKLTESGSLTVALGPQPTGKLTESGTLTVVLGPQPTEKLTESGSLTVALGPQPTEKLTESGSLFVVSSPLSTGKLAESGSLVLSGPLPTDKSTETASSVSSPPATGKLTESGSLSVVSSPLTTGKLTESSSFVLSGSLPAEKLTESGYFSVVSSPPNTGELTESGSLYLVSNPLTTGKMTESGSFEISGHFPVKSKSGSHHPHAFWKKVKSRFHPNDKSAQRLIACLKKKGCAFKRVHF", "length": 2133, "molWeight": 218677, "crc64": "1DFE1B328B072B8E", "md5": "F574FEF52BAC4C3A32F2C6C7B1E309A9"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 7, "Compositional bias": 9}, "uniParcId": "UPI00359F59AA"}, "cluster_size": 1, "family": "Danionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MKK8", "uniProtkbId": "A0AA96MKK8_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50083.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50083.1"}], "value": "Uncharacterized protein 19"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 436, "modifier": "EXACT"}, "end": {"value": 436, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50083.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50083.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460160", "properties": [{"key": "ProteinId", "value": "WNS50083.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MQLISFRKLQSCSHAYGPCGALSLHVNGIDISADSRSASIIAKFSLSVFDRGFTHRMLKWSTGLAVFSLLFLLSSSVDSDSGLLHSCSDFVPRRASPDCPQTDLSRCLYRPLLAVIEDGKCCPNCGERVNLTCEDEDGVHLEGAQWFPSVVPPVEVIVGGLSGLDPRFTCITCSCDSGGRFCSDLRRYCKSPRCNHPIVEPGKCCPFCPTEGSGGSGEDNAAIYLSDQTEACTDEQNVVRDHGECWSLVYGGQTTCMEVCCNDSRVLVTPPDCPPVRPCDAGQPAYGAALACCPQCSRGPVIAPKPAGEEFHLKECVGDLPFKIYLYKRQFQWDGRDSMAYALVNDPYVTILVFKLVEGRRFFVQSKVTWEKLLSRPSGRRYVFRGRTTSEKMTNLLTGEEATQSVLACRSDCARLMVSLLEPTKRPSCATVHTVQ", "length": 436, "molWeight": 47800, "crc64": "4BCC7FDD7759080E", "md5": "01A7113B05873B944DEEDE5B19A37476"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI002B29D624"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN39", "uniProtkbId": "A0AA96MN39_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50055.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50055.1"}], "value": "Transmembrane protein 272-like protein"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 73, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 94, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 141, "modifier": "EXACT"}, "end": {"value": 160, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 165, "modifier": "EXACT"}, "end": {"value": 187, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50055.1"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50055.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460132", "properties": [{"key": "ProteinId", "value": "WNS50055.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR040350", "properties": [{"key": "EntryName", "value": "TMEM272"}]}, {"database": "PANTHER", "id": "PTHR33444", "properties": [{"key": "EntryName", "value": "SI:DKEY-19B23.12-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR33444:SF11", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN 272-LIKE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGIAGAFKKEGKVGIFIVFRDAGCRRTLKSNCHMARAVHINNCRLNPMIPRWMIVFASAILIGITLDVLSYVWDAIYNYKRKVEERRYLNIFNILGWLVQLFYFAWVIVGTVWVLAYYGAWTHGGGQSCTTNPANPLCCEASVYLFSFVVIIFEWIALLLAVVVYVIAIILGICCISCISALGASAYKNLSGGD", "length": 194, "molWeight": 21635, "crc64": "B96FBC42F3AB73BE", "md5": "C14315B5BDADA6FBE71F110399292336"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 4}, "uniParcId": "UPI002B27E0D1"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P6A9", "uniProtkbId": "A0AAF0P6A9_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Paratelphusula gibbosa", "taxonId": 511413, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59283.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Paratelphusula"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012663"}], "value": "beta-N-acetylhexosaminidase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012663"}], "value": "3.2.1.52"}]}, "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59283.1"}], "value": "scaffold2068226"}}], "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "ecNumber": "3.2.1.52", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001231"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006285"}], "value": "Belongs to the glycosyl hydrolase 20 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 3, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "Glycoside hydrolase family 20 catalytic", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00728"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59283.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 319, "modifier": "EXACT"}, "end": {"value": 319, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59283.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59283.1"}], "value": "S85", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59283.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59283.1"}], "value": "S85", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59283.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515406", "properties": [{"key": "ProteinId", "value": "WMS59283.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004563", "properties": [{"key": "GoTerm", "value": "F:beta-N-acetylhexosaminidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.20.20.80", "properties": [{"key": "EntryName", "value": "Glycosidases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR015883", "properties": [{"key": "EntryName", "value": "Glyco_hydro_20_cat"}]}, {"database": "InterPro", "id": "IPR017853", "properties": [{"key": "EntryName", "value": "Glycoside_hydrolase_SF"}]}, {"database": "InterPro", "id": "IPR038901", "properties": [{"key": "EntryName", "value": "HEXDC-like"}]}, {"database": "PANTHER", "id": "PTHR21040", "properties": [{"key": "EntryName", "value": "BCDNA.GH04120"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21040:SF8", "properties": [{"key": "EntryName", "value": "BCDNA.GH04120"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00728", "properties": [{"key": "EntryName", "value": "Glyco_hydro_20"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF51445", "properties": [{"key": "EntryName", "value": "(Trans)glycosidases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "TLPIIKLMIDQVLQLHPGIDWLHIGSDEVYNLGECMRCQQYLLHNQFGKSDLFLHHVMSVAKYVKENYDVQPIMWDDEFRKIPLKVMKDSKVGEILEIMVWKYSSGIMVDLRSDIWEKYSSVFSGIWIASAFKGAANPDSYITNINDRLSNHKEWMEIYEMYKSTIPFRGIILTGWQRFDHFGVLCELLPQAIPSLAVNLMYINERKADHSALVRVGDILKCSSFINLDLQYLEYANKCDFPGSAFYEVSQKLYILKRDINTMMNNPHVTGWVSDYNIEHNFVSPQHAEQGLQDLTMLLFDYGKVMNEAETALSDVFDE", "length": 319, "molWeight": 37020, "crc64": "1E8CBDB471BF1600", "md5": "38D226CF4A2034CBD02DE0BD5712482C"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2AC365"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LIY7", "uniProtkbId": "A0AAN0LIY7_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65880.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65880.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65880.1"}], "value": "UGT"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009995"}], "value": "Belongs to the UDP-glycosyltransferase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Coiled coil", "location": {"start": {"value": 72, "modifier": "EXACT"}, "end": {"value": 99, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65880.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145333", "properties": [{"key": "ProteinId", "value": "WRV65880.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050271", "properties": [{"key": "EntryName", "value": "UDP-glycosyltransferase"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48043", "properties": [{"key": "EntryName", "value": "EG:EG0003.4 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48043:SF145", "properties": [{"key": "EntryName", "value": "FI06409P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00201", "properties": [{"key": "EntryName", "value": "UDPGT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGKLLFIPMLTYGHFNCAINIGRYLIDKNPKHEIYFLVSDLWEKKLMKIEPKFKSLVYITDENAWSFSKPKEKNENKENEIVNKKIEEKKDDLDSLTKIISKPDKDWSDSSLSKVKGLSKFFECLSSIYDNYKDQILKLVNDLDPNLILYDHVVYPSYLMNRPWANLMSINPLFMNHHELPPYSSGYSSKKKLAEKEWIEFRKEFLINSTDFLTKASLKLIEEGEPAMKLDSFFIVSPYFNIYIYPKEINYFNDKIKLPGKWLRLDSPLSPSQKYMSINKNDQESRLNYLNQLFSIPKDFLKEGEKLIFFSVGSMASAYEKLMTRLYQLISNVPNHKFIISKGPIDHIKELPSNCIGDKFVDQIKILQVVDLMISHGGNNSLTECFHFGVPLVILPLFSDQPDNAMRLVDLDFGYKLDPFRCTQEDFNSTIIKALNNKELTNKMEKISQRIKKDNGMIKVLNEIEKYLN", "length": 469, "molWeight": 54759, "crc64": "34460D7209F406B0", "md5": "3ED04F6956B1DF7DF5D27F93913835E9"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Coiled coil": 1}, "uniParcId": "UPI003246CB3F"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N6G5", "uniProtkbId": "A0AAJ6N6G5_9CYAN", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Anthocerotibacter panamensis", "taxonId": 2857077, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8IMN"}], "lineage": ["Bacteria", "Bacillati", "Cyanobacteriota", "Cyanophyceae", "Gloeobacterales", "Anthocerotibacteraceae", "Anthocerotibacter"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8IMN"}, {"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8IMO"}], "value": "CpcN"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004445"}], "value": "Cellular thylakoid membrane", "id": "SL-0045"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004445"}], "value": "Peripheral membrane protein", "id": "SL-9903"}, "orientation": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004445"}], "value": "Cytoplasmic side", "id": "SL-9910"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00775"}], "value": "Belongs to the phycobilisome linker protein family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 93, "modifier": "EXACT"}, "end": {"value": 272, "modifier": "EXACT"}}, "description": "PBS-linker", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51445"}]}, {"type": "Domain", "location": {"start": {"value": 326, "modifier": "EXACT"}, "end": {"value": 505, "modifier": "EXACT"}}, "description": "PBS-linker", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51445"}]}, {"type": "Domain", "location": {"start": {"value": 548, "modifier": "EXACT"}, "end": {"value": 727, "modifier": "EXACT"}}, "description": "PBS-linker", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51445"}]}, {"type": "Domain", "location": {"start": {"value": 765, "modifier": "EXACT"}, "end": {"value": 948, "modifier": "EXACT"}}, "description": "PBS-linker", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51445"}]}, {"type": "Domain", "location": {"start": {"value": 991, "modifier": "EXACT"}, "end": {"value": 1170, "modifier": "EXACT"}}, "description": "PBS-linker", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51445"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IMN"}, {"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IMO"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022549"}], "id": "KW-0042", "category": "Cellular component", "name": "Antenna complex"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022531"}], "id": "KW-0602", "category": "Biological process", "name": "Photosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022738"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00775"}], "id": "KW-0605", "category": "Cellular component", "name": "Phycobilisome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023078"}], "id": "KW-0793", "category": "Cellular component", "name": "Thylakoid"}], "references": [{"referenceNumber": 1, "citation": {"id": "38049400", "citationType": "journal article", "authors": ["Jiang H.W.", "Wu H.Y.", "Wang C.H.", "Yang C.H.", "Ko J.T.", "Ho H.C.", "Tsai M.D.", "Bryant D.A.", "Li F.W.", "Ho M.C.", "Ho M.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "38049400"}, {"database": "DOI", "id": "10.1038/s41467-023-43646-9"}], "title": "A structure of the relict phycobilisome from a thylakoid-free cyanobacterium.", "publicationDate": "2023", "journal": "Nat. Commun.", "firstPage": "8009", "lastPage": "8009", "volume": "14"}, "referencePositions": ["STRUCTURE BY ELECTRON MICROSCOPY (3.07 ANGSTROMS)"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IMN"}, {"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IMO"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8IMN", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "3.07 A"}, {"key": "Chains", "value": "5=1-1182"}]}, {"database": "PDB", "id": "8IMO", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "3.08 A"}, {"key": "Chains", "value": "5=1-1182"}]}, {"database": "SMR", "id": "A0AAJ6N6G5", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0030089", "properties": [{"key": "GoTerm", "value": "C:phycobilisome"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0031676", "properties": [{"key": "GoTerm", "value": "C:plasma membrane-derived thylakoid membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015979", "properties": [{"key": "GoTerm", "value": "P:photosynthesis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.10.3130.20", "properties": [{"key": "EntryName", "value": "Phycobilisome linker domain"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "InterPro", "id": "IPR001297", "properties": [{"key": "EntryName", "value": "PBS_linker_dom"}]}, {"database": "InterPro", "id": "IPR038255", "properties": [{"key": "EntryName", "value": "PBS_linker_sf"}]}, {"database": "PANTHER", "id": "PTHR34011:SF6", "properties": [{"key": "EntryName", "value": "PHYCOBILIPROTEIN APCE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR34011", "properties": [{"key": "EntryName", "value": "PHYCOBILISOME 32.1 KDA LINKER POLYPEPTIDE, PHYCOCYANIN-ASSOCIATED, ROD 2-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00427", "properties": [{"key": "EntryName", "value": "PBS_linker_poly"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "PROSITE", "id": "PS51445", "properties": [{"key": "EntryName", "value": "PBS_LINKER"}, {"key": "MatchStatus", "value": "5"}]}], "sequence": {"value": "MSDGLNIFLEMARDLTQTQNKSPYAVSRLGVTPLQPTATPQVAGMDPFLDMARRMAGRPVPKGNPFLDMARELTDNRALTLVKEFTAPSPYQQTETYGQERIRALGTIEAPRVTLRAPFTDEQFQGALYAIYRHIFGNTYVMESERPTTAESQLKDGRITVRGFIKLLAKSEVYRSRFFQKTSQNRFIELNHKLLLGRAPYDQAEISAHLDLWNTQGYDAEIDSYVESEEYLENFGEDVIPYFRGFKYQTGQSAQGFNRLLDLYGGWAGSDTDRNQSGQVARLTNSLVRPGQVVEPPVAPPLEFTREAERAAWLAGALTLPSSLGHTETHGQERIRAVGALEAAQVTLRAPFTEEQFQGALYAIYKQVFGNTYVMESERPTTAESQLKDGRITVRGFIRLLAKTEAYKSRFLYTTSQNRFIELNHKLLLGRAPYDQAEIIRHLDLWNSQGYDAEIDSYIESEEYQEFFGEEVVPFFRGFKYQVGQNPLGFNGLVRLYDGYAGSDTERNQSGQVARLTDRLSRPVREQSSVDRIERLLRSYTSPSPLEQTNTYGQERVQANAVLETPQVTLRAPFTEEQFQGALYAIYKQVFGNTYVMESERPATAESQLRDGRITVRGFIRLLAKSDTYKARFFNPATQTRFIELNHKLLLGRAPYDQAEISRHVALYTSQGYEAEIDSYLDSEEYQECFGEDTVPFFRGFTSQPGQSTEAFNRMVTLYDGYATSDSEWDRGGQSARLTDSLARSTMDQDPEYRIGNLISSYTRPSPYGQPQGYGQERIQATAVLERPRATLRVGTTENLEGVIYAIYQQVLGNTHVMTSERLLFAESQLRDGKLTVRGFIRQLAKSEAYKTRFFYPSSQTRFIELNHKLLLGRAPYDQAEISHHVTLYTSQGYDLEIDSYLDSEEYQENFGEDTVPFLRGFTSQPGQVTEAFNRMVNLNDGYATSDSGWSQSAEVARLTESLSRPVREAGASVRVERLLNALTQPSSLGQSPTFGQEQIQATAVLEESPVTLRAPFTEEQLQGALYAIYKQVLGKTHVMESERPTFAESQLRDGKLTVRGFVRQVAQSEAYKARFFNPAAQTRFIELNHKLLLGRAPYDQAEISRHVALYTSQGYEAEIDSYLDSEEYQENFGEDTVPFLRGFTSQPGQSTEAFNRMVTLYDGYAASDGQTPRPTDSLNEP", "length": 1182, "molWeight": 133857, "crc64": "EAE634BF0DE250E7", "md5": "22B5A9F917E6C4FD44FD182EFE9F189D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 5}, "uniParcId": "UPI001FD8868E"}, "cluster_size": 1, "family": "Anthocerotibacteraceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LJ52", "uniProtkbId": "A0AAN0LJ52_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34100.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34100.1"}], "value": "Ligated ion channel binding I - glutamate"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 432, "modifier": "EXACT"}, "end": {"value": 454, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 488, "modifier": "EXACT"}, "end": {"value": 506, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1114, "modifier": "EXACT"}, "end": {"value": 1133, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1374, "modifier": "EXACT"}, "end": {"value": 1399, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34100.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155026", "properties": [{"key": "ProteinId", "value": "WRW34100.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNNYTVNIIIPEVRPYIYLKNNQLYSQFKAGYDAINMLPSFKKKFIGTDYILGVKNKSGHYSGIIGSLERDDVDLIFYPLPIDMVDPPGIFTPVFWESSTYIISLASLPFNKNQDISFSFVSSNLVVTARKDLINTIDDLYKKKEYLPFFIKDHFILNYFISPFSNKKLKSIFERISSCKECIQTIEQHILSSVLYKNISFEKKVFLHDRSNIYLFKNVYCTGNSEKINSLGNLHISLPISKNYFALLVSKKIDLKLKLLIDKRMTHLRENNLSGKLISSLDKVSILDIKDSSKSFKKCFNEKSFEYSDKEYRNIKLTNIFIPELRPYFYVKNNRIVSQYQVAYEVLGLVSAFKPKYIPTNYVLGVKNKTGHYNGMIGSLERDDVDMVFYPLPIEISDPPGIFTPVFYETSSYILTLTSFPSKKYLDISSSLLNFDFTIILSFIFSFIILSLFTAKVLKLFKNVFDALFTFFRLSFKQDSCFNQNNNFRAFLLLIIFYHFIIITLFENSVNSNLVVKARSDLINTVDDLFKKKSLFPFFLKDHFAMNYFINPNSNKKMKNIFYRASICDDCIQTINIHATQVLLYKNITFHNKAFIFDRSFLNVMRNLYCTGNHEKINSLGSFYTSSPIIKNYFAFLMNKKINLKMKMIIDKRTLLIHETGILHRLFSFLDKLSFLDFKDSSQSFKKCINENINYIDNEYVRPYLYVKNYDFLSPYKVAREAINLLPPFKRKFYGVDYVLGMKNKTGHYNGMIGSLERDDVDLVFYPLPIDLSDPPGIFTPVFWESSTYIISLASLPSNKHLDISSSLLNFDFTIIFCHFILNYFVSSYNNEKIKKIFQRVSKCDDCIQKIEEHVTQVSLYRKFNFEKKAFIFDRSFMNIFKNLYCSSNHEKINFLGNFHTSLPITKNYFALLMNKKLKLHIQLLFNKRVTALRENNLSERLFYGLDQVSFLDFRENSFSFKKCMIENNSNNLKNRYEKIKIINILNLITQMFNYTVKISIPEVRPYVYIKGNKPFSSFKQLYTVINLLPEFKKKFIGVEYDLGTKNKSGHYNGMIGSLERNDIDVIFYLLPIDMSDPPGEFTPVFWESSTYIISLANYPSDKYLDISSSLLNFDYNIIILFILFFVLLSLLTYKVLKLFSSIFDAIFTFFCLSLKQDSSRVSNCSNCIQTMDEHITQSLLYKNFSFEKKAFIFDRTVKNVLKNLYCTGNHEKINSLGYFHTSLPILKNYFAFLMSRKLDIKLKKVFNKRVTALRENNLSEQIFNSIDEISVFNLKESRNKYYSSFMVINQIVSLLPNFNNKFIATDYRLGTKNKTGHYNGIIGKLQNDEVDLIFYPLPIEMIDPPGIFSKVFFESSSYIISLDNKPSNKYQDILYSSFNFSFDLIIIILLIFIALTFFETNVNLNLVVKIKNNPIDTIEDLYERPDYLPFFIKDHYTINYFNHPKSKEKVKKIYRRASNCDVCTNTLENHISLVLFYRNITFEKKVFIIDQLFLNVFKNVVCTGNHEKINSLGSLHISLYIFKNQFGYLLSKKISLYYRKLIDKRITIVSETVTVLRNVIEIKKLIF", "length": 1568, "molWeight": 183636, "crc64": "C4637BB84B1A7168", "md5": "5268AA9590BAA7A19AC69174D3B5A791"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 4}, "uniParcId": "UPI003253B038"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MPM7", "uniProtkbId": "A0AA96MPM7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50094.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50094.1"}], "value": "Tenascin-X-like protein 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 1564, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041698580"}, {"type": "Transmembrane", "location": {"start": {"value": 1531, "modifier": "EXACT"}, "end": {"value": 1559, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 219, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 223, "modifier": "EXACT"}, "end": {"value": 316, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 321, "modifier": "EXACT"}, "end": {"value": 407, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 411, "modifier": "EXACT"}, "end": {"value": 519, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 520, "modifier": "EXACT"}, "end": {"value": 616, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 617, "modifier": "EXACT"}, "end": {"value": 708, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 709, "modifier": "EXACT"}, "end": {"value": 808, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 943, "modifier": "EXACT"}, "end": {"value": 1036, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 1041, "modifier": "EXACT"}, "end": {"value": 1127, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 1131, "modifier": "EXACT"}, "end": {"value": 1239, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 1240, "modifier": "EXACT"}, "end": {"value": 1336, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 1337, "modifier": "EXACT"}, "end": {"value": 1429, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 1430, "modifier": "EXACT"}, "end": {"value": 1524, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50094.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460171", "properties": [{"key": "ProteinId", "value": "WNS50094.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00063", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "11"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "15"}]}, {"database": "InterPro", "id": "IPR050991", "properties": [{"key": "EntryName", "value": "ECM_Regulatory_Proteins"}]}, {"database": "InterPro", "id": "IPR003961", "properties": [{"key": "EntryName", "value": "FN3_dom"}]}, {"database": "InterPro", "id": "IPR036116", "properties": [{"key": "EntryName", "value": "FN3_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "PANTHER", "id": "PTHR46708:SF2", "properties": [{"key": "EntryName", "value": "FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46708", "properties": [{"key": "EntryName", "value": "TENASCIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00041", "properties": [{"key": "EntryName", "value": "fn3"}, {"key": "MatchStatus", "value": "12"}]}, {"database": "SMART", "id": "SM00060", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "15"}]}, {"database": "SUPFAM", "id": "SSF49265", "properties": [{"key": "EntryName", "value": "Fibronectin type III"}, {"key": "MatchStatus", "value": "10"}]}, {"database": "PROSITE", "id": "PS50853", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "13"}]}], "sequence": {"value": "MKITLLAVAIYLFTGINAQVPSINAPQSSAQNVSFLWSNNGACSGSIALYEVQYEAQGQTTPPPMMIMPQIAGVITVTQSAVSPSEGTASKTIRGLTPCTNYIVQLRANCTDGSSSNFSATVVFETASEAPLAPLNLTKTATTSTQIDVAWDSPSVCTAFITGYAVYQNGTKTLTNSTMPSFSFPGLDPNTEYMFRVAALISDQEGALSDILIARTTEAPPSVPLNLRGEALTNTSVRVAWDPPASANGVLVGYTVLYGVTTGDLTEELSVSVPSLQADIVGLGAMTTYFFSVFARNTANGTNSTEISIITPVMNPTTPSAPEQLRATETGATHLNLCWNPPLRDGTLAYYTVECNPGTFSFNTTGTCFNVTGLQPETQYTCSVTPFTAGGMAGTPSDMSTSTTISPNLAMPMNVMATTLSTTEIQVTWSHPPFNETIDQIFVNWVPSVPAGVPYTPGSTEIVCSSDNNPVMGMLNCNNITEFTILGLQEYITYAVTVIASNNAGNSSTGSATNTTMPAIPDGVATMVIPTPTYNSVSLSWTAVPFFSQNGPNVRYIVSITRVGSTTPLVQTVSTLTTTRGGLMPLTQYTVVITAINDVGNAVTPSAPVMFTTLETPPNGVTNIMVSADSTGMEANITWTAPTMGTATMYSIVISDANGIVTSESTNSPMYMATGLSPYILYTVTVTAATSGGNGPPTSHMFYTLQDLPTVTVRNVQGSGNSDGLTVSFDPITNPAEGRGNLTYTVCYMLRGSTDQVCQVTDTSPATFSGNFADSIYTVTVTPMTAAGQGMPKYSNRSRSYQFVSPMTFKIKELAVLATVLLLTGINAQVPSINAPQSSAQNVSFLWSNNGACSGSIALYEVQYEAQGQTTPPPMMIMPQIAGVITVTQSAVSPSEGTASKTIRGLTPCTNYTVQLRANCTDGSSSNFSATVVFETASEAPSAPLDFRGEALTSTSVRVAWDPPASANGVLVGYTVRYGVTTGALTEELSVSVPSLQADIVGLMAMAPYFFSVFARNTANGTESTEISIITPVMNPTTPSAPEQLRATETGATHLNLCWNPPLRDGTLDYYTVECNPGTFSFNTTGTCFNVTGLQPETQYNCSVTPFTTGGMAGTPSDMSTSTTISPNLAMPMNVMATTLSTTEIQVTWSHPPFNETIDQIFVNWVPSVPAGVPYTPGSFEIMCSSDNNPAMGMSNCSDITEFTISGLQEYITYAVTVIASNNAGNSSTGSATNTTMSAIPDGVATMVMPTPTYNSVSLSWTAVPFFSQNGPNVRYIVTITRMGFPTPLVRTVSTLTTTGEGLMPLTQYIVVITAINDVGNAVTSSAPVMFTTLETPPNGVTNIMVSADGTGMEANITWTAPTMGTATMYSIVISDAANGMVTSASTNSPMYMATGLSPYILYTVTITAATSGGNGPPTSHMFYTLQDLPTVTVGNVQGSGNSDGLTVSFDPITNPAEGRGNLTYTVCYMLRGSTDQVCQVTDTSPATFSGNFAGSIYTVTVTPMTAAGQGMPSTQIEVDTRNIPIRPHNLALIVTLAVVVPIVAVVVAVSLIVLFCLLAKAKS", "length": 1564, "molWeight": 164283, "crc64": "54A8E70F39C4EF69", "md5": "2EEBD9259A5A91C3D7DFD7472EC0ED58"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 13}, "uniParcId": "UPI002B2E9BF3"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN37", "uniProtkbId": "A0AA96MN37_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50108.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50108.1"}], "value": "Calx domain-containing protein"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 1496, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041666261"}, {"type": "Transmembrane", "location": {"start": {"value": 1468, "modifier": "EXACT"}, "end": {"value": 1495, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 1419, "modifier": "EXACT"}, "end": {"value": 1454, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1425, "modifier": "EXACT"}, "end": {"value": 1442, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1444, "modifier": "EXACT"}, "end": {"value": 1453, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022837"}], "id": "KW-0106", "category": "Ligand", "name": "Calcium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-0245", "category": "Domain", "name": "EGF-like domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50108.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460185", "properties": [{"key": "ProteinId", "value": "WNS50108.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0098794", "properties": [{"key": "GoTerm", "value": "C:postsynapse"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005432", "properties": [{"key": "GoTerm", "value": "F:calcium:sodium antiporter activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0098703", "properties": [{"key": "GoTerm", "value": "P:calcium ion import across plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007154", "properties": [{"key": "GoTerm", "value": "P:cell communication"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00054", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.2030", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "Gene3D", "id": "2.10.25.10", "properties": [{"key": "EntryName", "value": "Laminin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR051171", "properties": [{"key": "EntryName", "value": "CaCA"}]}, {"database": "InterPro", "id": "IPR038081", "properties": [{"key": "EntryName", "value": "CalX-like_sf"}]}, {"database": "InterPro", "id": "IPR003644", "properties": [{"key": "EntryName", "value": "Calx_beta"}]}, {"database": "InterPro", "id": "IPR000742", "properties": [{"key": "EntryName", "value": "EGF-like_dom"}]}, {"database": "PANTHER", "id": "PTHR11878:SF76", "properties": [{"key": "EntryName", "value": "CALX-BETA DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11878", "properties": [{"key": "EntryName", "value": "SODIUM/CALCIUM EXCHANGER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03160", "properties": [{"key": "EntryName", "value": "Calx-beta"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "SUPFAM", "id": "SSF141072", "properties": [{"key": "EntryName", "value": "CalX-like"}, {"key": "MatchStatus", "value": "9"}]}, {"database": "SUPFAM", "id": "SSF57196", "properties": [{"key": "EntryName", "value": "EGF/Laminin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00022", "properties": [{"key": "EntryName", "value": "EGF_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50026", "properties": [{"key": "EntryName", "value": "EGF_3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRKLAFAVVIIALLLGYVNAQLIMSTIQFTSAFQEVSEGDGTVEIVITADMPVDDSITLTFTVGDITTDSSDYNISGTFNMTFANGITTNESIPIDIGDTLYEEDESFILMISKTGDTNDNLFRLGAFSSTVIVIKDNDTITVSITNATTMTVPETGSSQFRIPLTLDVMLQTGLTPNHGIIATATGNLTTPAGVGSDFDSVVVVDFVGMVLILEIKEDDLHELDEALLVTITSSSDRTLMGASSSIQIIILDDDPISLEFAPLPATPFLESDISGTIRILSNIYSQEPIVMSLSIADVTTDMNDYNITSPVSITLDPFSNSTELVIEFDDYLFEMPIESFNLTLGLQVPLQPGIQFGSLSIITVEIMDDEVITAEFTEMNYDAVEESEMVAVQVNISIPTVDTGSIPDPFNFTIQLADGSATIAGADYVVSSVNVSMTISSSTVINVTIPFSDDDVLENNETIGISLTTGPDRVVTGADSNITINNNDSIILNFRETIYSVMEGELTELTLNVTDGQSDIDFGVELSFQPITANVSDYSSPTTMVTFSSGSTCQSLMFQTVVDNVFELNETVSVVVLSTTPANVVQIGNAPATIIIEDDEVMSIKFEPQGYSYTEDVGNATLLINITLPADGLQVSQAINLTVSSDNGTTQGAADFMAPMMLAIENLGMPVAVGNETFVELQLMITLADDDILEATEMFTVTLGSDNPRILFDVDTAMINITNDDAIEVKFNETSISVNEEDVNTTVTVFLVASAMAAFEYNITIEATDITTSMDDRSLPATVMTILPGTTVLEIPLTILHDLIFENDEVFSLNITETSHPNVTIGGNNQVIITIRDNEMISITVDGNFTFEEGDDTNTTRYVTASSNIPDIAPGVTIPIQWIITPFNGPTGLDSDDYFITQDLIMELDQTNSSQTELMLAINIVGDQLLESDEIILVEINSTHPRVNITMNSARATVLNDDALEINFNVTSAVVDESQGNYSIVLIANGTSEYPYTVVFQYTDISTDSNDYIEVTEVEFLQNTAETEFQLNISDYLFEDIEEILQINFTLRDPTNLFVGADSTLQITIRDDEVITAEFSQASYMANEDSTEAILRISFQLPNQGLGINISYGLEITDGTAISPDDYDSSQNSVLLQPTTSASATLDVIVPIVPDTILERDQDFTAALNSTNERLMIAVLSSATVTITDDDILLVNFQVLATNLTETVGLVTILVGANTTSEFPYNITTNVTDLTTSQDDYIVDGNSSIIKFNVNSTYTSIVFAAYNDEVYEDTLEEVLLSMIETSTPEVLIGDMSQVKITIIDDEMVSVQYNASSYALMEGAGSSVLGLQATLPSGGSEVPIVVANSPMDITARETIDYTQASNMSTFPANMSFSELVYNLINDSIPEEDEVFGVTIVPVSPRVTIDVQVANVTIVNDDACPCLNGGECIFFPINDTLRCACTAEYVGQTCQTRVAEPFEEISAPIVAGVTAGVVGIAIIAIAVVFLVIILCVV", "length": 1496, "molWeight": 161552, "crc64": "56E0C8D94C67832B", "md5": "7C1726C65B1BEE8B0D601D27BA34C14C"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 1, "Disulfide bond": 2}, "uniParcId": "UPI002B285759"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0MUL5", "uniProtkbId": "A0AAU0MUL5_UREUN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Urechis unicinctus", "commonName": "Fat innkeeper worm", "synonyms": ["Chinese penis fish"], "taxonId": 6432, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59943.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Echiura", "Xenopneusta", "Urechidae", "Urechis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59943.1"}], "value": "Heat shock protein family A member 12 variant X4"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59943.1"}], "value": "HSPA12"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007381"}], "value": "Belongs to the heat shock protein 70 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59943.1"}], "id": "KW-0346", "category": "Biological process", "name": "Stress response"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FQL9M4QGPVUS3", "citationType": "submission", "authors": ["Liu D.D."], "publicationDate": "FEB-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59943.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OM803164", "properties": [{"key": "ProteinId", "value": "WOS59943.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0140662", "properties": [{"key": "GoTerm", "value": "F:ATP-dependent protein folding chaperone"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd10229", "properties": [{"key": "EntryName", "value": "ASKHA_NBD_HSP70_HSPA12"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.90.640.10", "properties": [{"key": "EntryName", "value": "Actin, Chain A, domain 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR043129", "properties": [{"key": "EntryName", "value": "ATPase_NBD"}]}, {"database": "InterPro", "id": "IPR013126", "properties": [{"key": "EntryName", "value": "Hsp_70_fam"}]}, {"database": "PANTHER", "id": "PTHR14187", "properties": [{"key": "EntryName", "value": "ALPHA KINASE/ELONGATION FACTOR 2 KINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14187:SF5", "properties": [{"key": "EntryName", "value": "HEAT SHOCK 70 KDA PROTEIN 12A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00012", "properties": [{"key": "EntryName", "value": "HSP70"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53067", "properties": [{"key": "EntryName", "value": "Actin-like ATPase domain"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MAAGPSTHPFVAVAALDVGAAFSGYAFSFRTKPEDVTLFKLWGASCGIPCSFKTTTCLLLNANGELDSFGYEAQNKYLTLEEDEMNDYTFYEGFKMQLYDRKDLSRTTCVSSRNNRTCSLMDLMTFSLTYLKDSLIKHANQQTSGDVTASLLRWVVTVPAIWDDSAKQFMREAAVKAGLDDNTNASQLLIALEPEAASIQCRGTSVNSIGVEAGDRSMDSTGQLDVGTKFLVVDAGGGTLDMTAQEVLPEAQMQVLCCANGGPFGGVRVNELIAELLNQIYGADVMKRYREECTADYGALMNNIEVKKRTINREKKATFNLPISQALAEIATDYHKKPFAECISADMMEKGVVARSGILKIPHSMVLKAVTTITDHIVQNVDDQLKQSEVAGVSYIVMVGGFSESPVLQGAIKEQFGARYTVIIPSDASTAVLSGAVAFGHNPNVIYARRAQKTCAVEMWPPFVEGRHPESRKVVADDGACLVRGAVHVLVKKGEVVHRDEVRSYCVTPVYAAQPSIPIKVYRTDATDVMYADDPGMEQVKCCAVKLPGTGMHREAEVKFKFGETEVKIEAWDVLKGHMVHATYSCL", "length": 587, "molWeight": 64091, "crc64": "1777AB727F54A9F0", "md5": "89E6B8784B50DA6D8E86A61FBD72862D"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0035D35421"}, "cluster_size": 1, "family": "Urechidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LI60", "uniProtkbId": "A0AAN0LI60_9LAMI", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Syringa oblata", "taxonId": 178762, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL58346.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "asterids", "lamiids", "Lamiales", "Oleaceae", "Oleeae", "Syringa"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL58346.1"}], "value": "Terpene synthase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL58346.1"}], "value": "TPSa"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001946"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004721"}], "value": "Secondary metabolite biosynthesis; terpenoid biosynthesis"}], "commentType": "PATHWAY"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007727"}], "value": "Belongs to the PC-esterase family. TBL subfamily"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006333"}], "value": "Belongs to the terpene synthase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 2, "modifier": "EXACT"}, "end": {"value": 140, "modifier": "EXACT"}}, "description": "Terpene synthase N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01397"}]}, {"type": "Domain", "location": {"start": {"value": 197, "modifier": "EXACT"}, "end": {"value": 434, "modifier": "EXACT"}}, "description": "Terpene synthase metal-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03936"}]}, {"type": "Domain", "location": {"start": {"value": 476, "modifier": "EXACT"}, "end": {"value": 529, "modifier": "EXACT"}}, "description": "Trichome birefringence-like N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF14416"}]}, {"type": "Domain", "location": {"start": {"value": 530, "modifier": "EXACT"}, "end": {"value": 795, "modifier": "EXACT"}}, "description": "Trichome birefringence-like C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF13839"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023239"}], "id": "KW-0456", "category": "Molecular function", "name": "Lyase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022968"}], "id": "KW-0735", "category": "Domain", "name": "Signal-anchor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-MO10HU5N4AR3", "citationType": "submission", "authors": ["Gao J."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL58346.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP693223", "properties": [{"key": "ProteinId", "value": "WZL58346.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000287", "properties": [{"key": "GoTerm", "value": "F:magnesium ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0010333", "properties": [{"key": "GoTerm", "value": "F:terpene synthase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016740", "properties": [{"key": "GoTerm", "value": "F:transferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016102", "properties": [{"key": "GoTerm", "value": "P:diterpenoid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00684", "properties": [{"key": "EntryName", "value": "Terpene_cyclase_plant_C1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.600.10:FF:000007", "properties": [{"key": "EntryName", "value": "Isoprene synthase, chloroplastic"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.50.10.130:FF:000001", "properties": [{"key": "EntryName", "value": "Isoprene synthase, chloroplastic"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.600.10", "properties": [{"key": "EntryName", "value": "Farnesyl Diphosphate Synthase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.50.10.130", "properties": [{"key": "EntryName", "value": "Terpene synthase, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008949", "properties": [{"key": "EntryName", "value": "Isoprenoid_synthase_dom_sf"}]}, {"database": "InterPro", "id": "IPR026057", "properties": [{"key": "EntryName", "value": "TBL_C"}]}, {"database": "InterPro", "id": "IPR025846", "properties": [{"key": "EntryName", "value": "TBL_N"}]}, {"database": "InterPro", "id": "IPR034741", "properties": [{"key": "EntryName", "value": "Terpene_cyclase-like_1_C"}]}, {"database": "InterPro", "id": "IPR044814", "properties": [{"key": "EntryName", "value": "Terpene_cyclase_plant_C1"}]}, {"database": "InterPro", "id": "IPR001906", "properties": [{"key": "EntryName", "value": "Terpene_synth_N"}]}, {"database": "InterPro", "id": "IPR036965", "properties": [{"key": "EntryName", "value": "Terpene_synth_N_sf"}]}, {"database": "InterPro", "id": "IPR050148", "properties": [{"key": "EntryName", "value": "Terpene_synthase-like"}]}, {"database": "InterPro", "id": "IPR005630", "properties": [{"key": "EntryName", "value": "Terpene_synthase_metal-bd"}]}, {"database": "InterPro", "id": "IPR008930", "properties": [{"key": "EntryName", "value": "Terpenoid_cyclase/PrenylTrfase"}]}, {"database": "PANTHER", "id": "PTHR31225:SF221", "properties": [{"key": "EntryName", "value": "(-)-GERMACRENE D SYNTHASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31225", "properties": [{"key": "EntryName", "value": "OS04G0344100 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13839", "properties": [{"key": "EntryName", "value": "PC-Esterase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14416", "properties": [{"key": "EntryName", "value": "PMR5N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01397", "properties": [{"key": "EntryName", "value": "Terpene_synth"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03936", "properties": [{"key": "EntryName", "value": "Terpene_synth_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SFLD", "id": "SFLDS00005", "properties": [{"key": "EntryName", "value": "Isoprenoid_Synthase_Type_I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SFLD", "id": "SFLDG01019", "properties": [{"key": "EntryName", "value": "Terpene_Cyclase_Like_1_C_Termi"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48239", "properties": [{"key": "EntryName", "value": "Terpenoid cyclases/Protein prenyltransferases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48576", "properties": [{"key": "EntryName", "value": "Terpenoid synthases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPDDSLHKLDLVDAIQRLGVGYHFETEIEKSLKYVYDTCHENYENQDGDLHTIALRFRLLRQQGYYVSCDVFDKFKDHQGKFDESLVSSLQGLLSLYEAAHFRVHGEEILEEALKFTTTHLDSSLFHIRNCVSRQVSEALEMPIHKTLTRLGARKFLSIYQQDESHNDILLNFAKLDFNILQKMHQKELSDITRWWKSLEFGSKLPFARDRVVECYFWILSIYFEPEYAISRKILTKVISMFSVIDDIYDVYGTLDELKLFTDAIERWNLINDIDELPLYMKDCFNALSNVCVEIAEELGKTGRWYGIHYVIKEMKNLLGAYYEEAKWAYNGYMPIHMEEYMKVALMSSGYIMLSTTCLVGMGESVTEEAFDWISSKSIAAKASSIIARLMDDMAGHGFEQKVSAVECYMNEKGASKEEAFAEFQRLVTNAWKDINQECLHPTMVPMAILMRVVNLARVINLLYGDGDGINQSNAKKCDLFEGSWVHDSSSPLYNSRSCPFIEREFNCQNNGRSDTLYLQYKWQPHACNLSRFDGHDFLQRFKGKSIMFVGDSLSRNQWQSLTCLLYTALPSTKFNVSRVGDISTFTFTDFDVEVMLDRSVYLVDVVGEAEGRILKLDSIERGKHWKGIDMLIFNTWHWWNRRGATQPWDYIQVGQQLYQDMDRVVAFEKALTTWAKWVDTNIDPAKTKVFFQGISPSHYNGSTWDEPSAKSCVGQKEPLAGSTYPGGLPYALTVLKKVLGTIKKPVTLLDVTNLSLLRKDGHPSIYGLGGRTGMDCSHWCLAGVPDTWNQILFSLIL", "length": 798, "molWeight": 91662, "crc64": "115FFBA8469BF0AF", "md5": "441F59ED89547A3D6CFFB04E21E50AE1"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "PATHWAY": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 2}, "countByFeatureType": {"Domain": 4}, "uniParcId": "UPI003252C3E6"}, "cluster_size": 1, "family": "Oleaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P2W1", "uniProtkbId": "A0AAU7P2W1_CALMC", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Callistoctopus minor", "commonName": "Octopus", "synonyms": ["Octopus minor"], "taxonId": 515824, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35917.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Cephalopoda", "Coleoidea", "Octopodiformes", "Octopoda", "Incirrata", "Octopodidae", "Callistoctopus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35917.1"}], "value": "Tryptophan-5-hydroxylase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35917.1"}], "value": "TPH"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Fe(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001954"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29033"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009712"}], "value": "Belongs to the biopterin-dependent aromatic amino acid hydroxylase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 184, "modifier": "EXACT"}, "end": {"value": 226, "modifier": "EXACT"}}, "description": "Biopterin-dependent aromatic amino acid hydroxylase family profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00351"}]}, {"type": "Domain", "location": {"start": {"value": 244, "modifier": "EXACT"}, "end": {"value": 322, "modifier": "EXACT"}}, "description": "Biopterin-dependent aromatic amino acid hydroxylase family profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00351"}]}, {"type": "Coiled coil", "location": {"start": {"value": 313, "modifier": "EXACT"}, "end": {"value": 344, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B1PARK2TANKH3", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35917.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP889618", "properties": [{"key": "ProteinId", "value": "XBS35917.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043005", "properties": [{"key": "GoTerm", "value": "C:neuron projection"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004510", "properties": [{"key": "GoTerm", "value": "F:tryptophan 5-monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0009072", "properties": [{"key": "GoTerm", "value": "P:aromatic amino acid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.30.70.260", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.800.10", "properties": [{"key": "EntryName", "value": "Aromatic amino acid hydroxylase"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001273", "properties": [{"key": "EntryName", "value": "ArAA_hydroxylase"}]}, {"database": "InterPro", "id": "IPR036951", "properties": [{"key": "EntryName", "value": "ArAA_hydroxylase_sf"}]}, {"database": "InterPro", "id": "IPR036329", "properties": [{"key": "EntryName", "value": "Aro-AA_hydroxylase_C_sf"}]}, {"database": "InterPro", "id": "IPR019774", "properties": [{"key": "EntryName", "value": "Aromatic-AA_hydroxylase_C"}]}, {"database": "PANTHER", "id": "PTHR11473", "properties": [{"key": "EntryName", "value": "AROMATIC AMINO ACID HYDROXYLASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11473:SF16", "properties": [{"key": "EntryName", "value": "TRYPTOPHAN 5-HYDROXYLASE 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00351", "properties": [{"key": "EntryName", "value": "Biopterin_H"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF56534", "properties": [{"key": "EntryName", "value": "Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKPRVMLLTRMIQRGQDFSLRCPRYQILFKIQFWETIVNWIIVEIELQNYNIGKLDGRVERWNIRITFDLAAFDNKVNVTHIESRRSQMEDSEYDIFINVESSKLAIEDLLEKLQLQIPDDVGNVKAFPTCPEEPDVVNQYLELNTNRRSKHLGHCVQRTKQALSYIFLQAAFKKFAVANEILRLQNNIPQLEDVAKFLKERTGFTVRPVAGYLSSRDFLAGLAFRLGLASLGASDFEIAKLASHVLTDAAIKKPFNPDKVIEQECQVSTYQDAYFVSESFKEAQNQIREFALNIKRPFTVRYDPYSQSVMVLEKARKRKNREKDKCKIENKNKNDNKKTTEKQIVMIIQIHFCIFKLSVDNKEKKIKRIPQNK", "length": 374, "molWeight": 43675, "crc64": "ABCE10A7849B1F3C", "md5": "AA8BCA5FED16E3F0B3CE124D8666F2DF"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2, "Coiled coil": 1}, "uniParcId": "UPI0035D383D3"}, "cluster_size": 1, "family": "Octopodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LH83", "uniProtkbId": "A0AAN0LH83_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65906.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65906.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65906.1"}], "value": "UGT"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 440, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042811763"}, {"type": "Domain", "location": {"start": {"value": 298, "modifier": "EXACT"}, "end": {"value": 412, "modifier": "EXACT"}}, "description": "Glycosyl transferase family 28 C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF04101"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65906.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145359", "properties": [{"key": "ProteinId", "value": "WRV65906.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR007235", "properties": [{"key": "EntryName", "value": "Glyco_trans_28_C"}]}, {"database": "InterPro", "id": "IPR050426", "properties": [{"key": "EntryName", "value": "Glycosyltransferase_28"}]}, {"database": "PANTHER", "id": "PTHR48050", "properties": [{"key": "EntryName", "value": "STEROL 3-BETA-GLUCOSYLTRANSFERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48050:SF13", "properties": [{"key": "EntryName", "value": "STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF04101", "properties": [{"key": "EntryName", "value": "Glyco_tran_28_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGKLLFLTMLTSSQIKVCVAVAKKIIELFGDKHEIYIPVDKDWEPKVKEMCPEIKCITFQRPSEELQRQFFARTGKKKEDVFAEICEQYNQIWCNFDRAEVVNRMASFYKIIFNHLIKFHPIVNEIVKQVAPDFIVTSFHVSTPLGIDRNIPYAMLLTSSPTFFGHEFLPPPMSDLPSEPTLENIKIWEKFFEEAYLLEHFDMKERINFWLKQRNCPNLDERNFYLVESPYLNISLYPKEIDYNPNLVKLPGKWLKLDSAICNPLPEPIVIPEKLKNLPGKLVYVDFGNQPFIYLYHVKEVLKLLPTLKHRFIVCTGSIDLKDADNIYTEKNIESLSALQVADVVICHGGTKIITDSFHLGVPQIIIPLFGDQIDNGRRIDDKKLGIRLYTSEISHQVIDEAINKSCNPTLMKKLKEISNRIKTENGLKNVCLEICKFLK", "length": 440, "molWeight": 50985, "crc64": "01BBCAD13030B2D6", "md5": "5A5B6A6E3A6B4BF1640A439765318CF7"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00324AFFDB"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0D5", "uniProtkbId": "A0AA96S0D5_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50030.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363063"}], "value": "Hexosyltransferase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363063"}], "value": "2.4.1.-"}]}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004323"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363063"}], "value": "Golgi apparatus membrane", "id": "SL-0134"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004323"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363063"}], "value": "Single-pass type II membrane protein", "id": "SL-9906"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008661"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363063"}], "value": "Belongs to the glycosyltransferase 31 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 57, "modifier": "EXACT"}, "end": {"value": 112, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 82, "modifier": "EXACT"}, "end": {"value": 97, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 99, "modifier": "EXACT"}, "end": {"value": 112, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363063"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023034"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363063"}], "id": "KW-0333", "category": "Cellular component", "name": "Golgi apparatus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022968"}], "id": "KW-0735", "category": "Domain", "name": "Signal-anchor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50030.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460107", "properties": [{"key": "ProteinId", "value": "WNS50030.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0000139", "properties": [{"key": "GoTerm", "value": "C:Golgi membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006486", "properties": [{"key": "GoTerm", "value": "P:protein glycosylation"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.90.550.50", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002659", "properties": [{"key": "EntryName", "value": "Glyco_trans_31"}]}, {"database": "InterPro", "id": "IPR029044", "properties": [{"key": "EntryName", "value": "Nucleotide-diphossugar_trans"}]}, {"database": "PANTHER", "id": "PTHR11214:SF3", "properties": [{"key": "EntryName", "value": "BETA-1,3-GALACTOSYLTRANSFERASE 6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11214", "properties": [{"key": "EntryName", "value": "BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01762", "properties": [{"key": "EntryName", "value": "Galactosyl_T"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53448", "properties": [{"key": "EntryName", "value": "Nucleotide-diphospho-sugar transferases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLKKGLDKWSLKTLIATSVIILCLTNIILLTTSLAKSCDRLYCKLQAQRVRCQLTSEQQQVVPKPTQPDEDTKCNSTTTTQNPSPASVNVNSTSTTSKGHSERDEEENQQLHRQLEETEVTQVILQVIIFSRPTSYSLRNACRATWMNSYIRNPAVNFKFAIGTGHLDRKSNESLNKEASVHKDVIFFEGHNESYGKQCVEKLILSLNWVSENAKAKYFLKTDDDCYVRIGYILTLLKIRELITNQVFLMGTIAKFLIPQRDGKWAEDNWKLTHFYPPFAYGSGYILPVSLVKRISADNRSSPLRRLRNEDVTLGVWLLPYDLQYVNIKRFQKVDHAICPYDSKQIAFFHYSQSPTFMYKAHECLPP", "length": 367, "molWeight": 42157, "crc64": "A82B728A56A41012", "md5": "67937ADE3BB017ADF9FDCECB4BEB9879"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Region": 1, "Compositional bias": 2}, "uniParcId": "UPI002B310342"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MKK0", "uniProtkbId": "A0AA96MKK0_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50068.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50068.1"}], "value": "DOMON domain-containing protein"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 2276, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041674075"}, {"type": "Domain", "location": {"start": {"value": 459, "modifier": "EXACT"}, "end": {"value": 573, "modifier": "EXACT"}}, "description": "DOMON", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50836"}]}, {"type": "Region", "location": {"start": {"value": 611, "modifier": "EXACT"}, "end": {"value": 647, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1392, "modifier": "EXACT"}, "end": {"value": 1413, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1489, "modifier": "EXACT"}, "end": {"value": 1510, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1586, "modifier": "EXACT"}, "end": {"value": 1607, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1834, "modifier": "EXACT"}, "end": {"value": 1897, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 613, "modifier": "EXACT"}, "end": {"value": 625, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 628, "modifier": "EXACT"}, "end": {"value": 645, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1392, "modifier": "EXACT"}, "end": {"value": 1412, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1489, "modifier": "EXACT"}, "end": {"value": 1509, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1586, "modifier": "EXACT"}, "end": {"value": 1606, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1834, "modifier": "EXACT"}, "end": {"value": 1868, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1869, "modifier": "EXACT"}, "end": {"value": 1894, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50068.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460145", "properties": [{"key": "ProteinId", "value": "WNS50068.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd09631", "properties": [{"key": "EntryName", "value": "DOMON_DOH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR045266", "properties": [{"key": "EntryName", "value": "DOH_DOMON"}]}, {"database": "InterPro", "id": "IPR005018", "properties": [{"key": "EntryName", "value": "DOMON_domain"}]}, {"database": "PANTHER", "id": "PTHR46901", "properties": [{"key": "EntryName", "value": "GH04942P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46901:SF2", "properties": [{"key": "EntryName", "value": "GH04942P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03351", "properties": [{"key": "EntryName", "value": "DOMON"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00664", "properties": [{"key": "EntryName", "value": "DoH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49344", "properties": [{"key": "EntryName", "value": "CBD9-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50836", "properties": [{"key": "EntryName", "value": "DOMON"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNSVLGVAILVGVLASAAAQSIGFNGNQPVIGDTTVTFSWTFTGVTADGFTCSLNGGTATSCQSPHVVQQSDLLNGKNTLAVIALFGNGQSLGPLALEVTVSQSSSSNQVQFKGLAPVVGDNGVSFSWELTGASADKFTCSLNGATAEDCSSPFSVAKSGLSDGLNTLAVTAVVGGQNVGPVNLEVTVSKSSSSNQVQFSGQTPVVGDNDVSFSWELTGASADKFTCSLNGATAEDCSSPFSVAKADLSDGLNTLAVTAVVGGQNVGPVNLEVTVSQSSSSNQVKFSGQTPVVGDNDVSFSWELTGATADKFTCSLNGGAAVDCTSPHSVSKSALQAGSNTLSVTAIVSGLVLDPLDFTVSSGGDSVQFNGEANLNGNSVEFTWSVTGVSGVTYQCSLNGEALFACSSGHSVALSALQDGENVLSVTASGEGVSFSGPLELKVTKSFSVSTGTLSANGGAYSVAYTIHGDVVSFVVSAETTGWVGLGFSEDQLMPNSDVVVGAADSDGGMFVFDGFANALAQPPVDSQQDITDFSATHEGGMTTVTFSRKLVTGDSDDDLPVTKSLYWLWAYGGSFSGSDPTSIGYHFTNRGVFPSNMTLSATAATASFSGSNGPLTGATSTPTTGDPPVATSGPGTTPAPGTVSFSGNAESSGNSVVFTWSVTGVSGVTYQCSFNGEASFVCTSPYTVDVSSDPSVQDGLNVLSVTASGGGVTFESPLELSFTKFHSVEAPVLSSPTVHSVDVPVLPSPAVHSVEAPVLPSPAVHSVEAPVPSSPTVHSVDVPVLPSLAVHSVDVSVLPSPAVHSVDAPVLSSPTVHSVEAPVLSSLTVHSVDVPVLPSPAVHSVDAPVLSSPTVHSVEAPVLSSPTVHSVEAPVLSSPTVHSVDVPVLSPPIIHSVDVPVLTSSHTDLPSYRILHPPNFTWGSLDGRDFDVLINDAYNEVVHWKHNVFEVPRGKAGNSFVAELCRLLEQFADDTAMECISMRAAMTIPALLLQKPHRRSTSKDHISCLERRLKCWLAGDIQSLLHEGRSIQNTLDKMHRRKKNDTASISRSFENLVSKGNIKAAIRLITEQNGRGCLPLRGEQPDGRSVKDHLLEKHPSSQPVDPTALSDCTPAPIPHPTFYDQIDGPFIRSIALHMSGSAGPSGLDAKAWKRLCSAFHNTSKDLCNALAKIARKICTTFVDPQGLEAFTACRLIALDKDPGVRPIGVGETVRRLISKAILRVTKVEIQKVAGSSQLCAAESSGNSVEFTWSVTGVSGVTYQCSFNGGDPFVCTSPYTVDVSDPSVQDGLNVLSVTASGGGVTFESPLELSFTKSESSGNSVEFTWSVTGVSGVTYQCSFNGGDPFVCTSPYTVDVSDPSVQDGLNVLSVTASGGGVTFESPLELSFTKSVSTTSSPGTTPTPGTVTFSGNAESSGNSVEFTWSVTGVSGVTYQCSFNGGDPFVCSSSYTVDVSDPSVQDGLNVLSVTASGGGVTFESPLELSFTKSVSTTSSPGTTPTPGTVSFSGNAESSGNSVEFTWSVTGVSGVTYQCSFNGGDPFVCSSPYTVDVSDPSVQDGLNVLSVTASGGGVTFESPLELSFTKSVSTTSSPGTTPTPGTVSFSGNAESSGNSVEFTWSVTGVSGVTYQCSFNGGDPFVCSSPYTVDVSDPSVQDGLNVLSVTASGGGVTFESPLELSFTKSESSGNSVEFTWSVTGVSGVTYQCSFNGGDPFVCTSPYTVDVSSDPSVQDGLNVLSVTASGGGVTFESPLELSFTKSESSGNAVEFTWSVTGVSGVTYQCSFNGGDPFVCTSPYTVDVSSDPSVQDGLNVLSVTASGGGVTFESPLELSFTKTVTPTSEPGTVPAQTSEPGTVPAQTSEPGTVPAQTSDPGPISTPTSSPGTPTPGSVTFSGNAESSGNSVEFTWSAVTGVSGVTYQCSFNGGDPFVCTSPYTVDVSDPSVQDGLNVLSVTASGGGVTFESPLELSFTRIEAVGGSVVFRWSFTGATDLPLMCSLNGGEFFDCQSPYEVDFSDLPDGDNVLTVVAKRGEDEVARGSVTFTKLTTTPEEGAGSVTVEWETDPDLTYKCFLNDELRNSCTSPFELSEEEQVAATTVVRVESFRGEMQVRVVGETVVESCRFTGISSPDRAYLWPEGYAMFSWTSEGNVEENRCTLGGGADFPCQSGLHFNVSAVTAGTHRGEVIAYCQGKPIGREVLRFRAQSGIPRDPDNCARLLVSDHVATYNRSASTVTVAFSTNIPSSCVCRLPADNRRAIQSCELKWIIVKLNVFISLLYV", "length": 2276, "molWeight": 235484, "crc64": "1A33864B7BD1534A", "md5": "F1853E2426B997CEB40407385A40633F"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 5, "Compositional bias": 7}, "uniParcId": "UPI002B2B1D5E"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA97BBH7", "uniProtkbId": "A0AA97BBH7_SALSA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Salmo salar", "commonName": "Atlantic salmon", "taxonId": 8030, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA06360.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Protacanthopterygii", "Salmoniformes", "Salmonidae", "Salmoninae", "Salmo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA06360.1"}], "value": "Apoptosis-associated speck-like protein containing a CARD"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004514"}], "value": "Cytoplasm, cytosol", "id": "SL-0091"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "CARD", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50209"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022859"}], "id": "KW-0391", "category": "Biological process", "name": "Immunity"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023198"}], "id": "KW-0395", "category": "Biological process", "name": "Inflammatory response"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022588"}], "id": "KW-0399", "category": "Biological process", "name": "Innate immunity"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4CJ46KCEDKA54", "citationType": "submission", "authors": ["Acevedo-Castillo W.A.", "Moran-Figueroa R.", "Vargas-Chacoff L.", "Morera F.J.", "Pontigo J.P."], "title": "Revealing the Salmo salar NLRP3 Inflammasome: Insights from Structural Modeling and Transcriptome Analysis.", "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA06360.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR552112", "properties": [{"key": "ProteinId", "value": "WOA06358.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "EMBL", "id": "OR552114", "properties": [{"key": "ProteinId", "value": "WOA06360.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005829", "properties": [{"key": "GoTerm", "value": "C:cytosol"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0006954", "properties": [{"key": "GoTerm", "value": "P:inflammatory response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0045087", "properties": [{"key": "GoTerm", "value": "P:innate immune response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0042981", "properties": [{"key": "GoTerm", "value": "P:regulation of apoptotic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd08330", "properties": [{"key": "EntryName", "value": "CARD_ASC_NALP1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.533.10", "properties": [{"key": "EntryName", "value": "Death Domain, Fas"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001315", "properties": [{"key": "EntryName", "value": "CARD"}]}, {"database": "InterPro", "id": "IPR033516", "properties": [{"key": "EntryName", "value": "CARD8/ASC/NALP1_CARD"}]}, {"database": "InterPro", "id": "IPR011029", "properties": [{"key": "EntryName", "value": "DEATH-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR051249", "properties": [{"key": "EntryName", "value": "NLRP_Inflammasome"}]}, {"database": "PANTHER", "id": "PTHR46985:SF2", "properties": [{"key": "EntryName", "value": "APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46985", "properties": [{"key": "EntryName", "value": "NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00619", "properties": [{"key": "EntryName", "value": "CARD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47986", "properties": [{"key": "EntryName", "value": "DEATH domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50209", "properties": [{"key": "EntryName", "value": "CARD"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MESLSLLPDQAATPQSSQDQSAVMETKQYGAQFVDDNMEKLVQRITMVMPIADGLYQKKMIHDEDYYEITAAQTSMSKMRKLYVALKPGGVVAKSAFYKILLEQQSLLVEELGGVGQK", "length": 118, "molWeight": 13166, "crc64": "FA7A3FB170C292E4", "md5": "7A4807B342D12710439DE9F17149DB87"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B28436E"}, "cluster_size": 1, "family": "Salmonidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7B9P2", "uniProtkbId": "A0AAU7B9P2_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC30854.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC30854.1"}], "value": "IRX4 isoform 4 transcript variant 6"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC30854.1"}], "value": "IRX4 isoform 4"}}], "features": [{"type": "Region", "location": {"start": {"value": 28, "modifier": "EXACT"}, "end": {"value": 78, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 62, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "33919200", "citationType": "journal article", "authors": ["Fernando A.", "Liyanage C.", "Moradi A.", "Janaththani P.", "Batra J."], "citationCrossReferences": [{"database": "PubMed", "id": "33919200"}], "title": "Identification and Characterization of Alternatively Spliced Transcript Isoforms of IRX4 in Prostate Cancer.", "publicationDate": "2021", "journal": "Genes (Basel)", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC30854.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-3JVS11EV10VTP", "citationType": "submission", "authors": ["Batra J."], "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC30854.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP835324", "properties": [{"key": "ProteinId", "value": "XBC30854.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MVRDLRMGAWHQPLPPTTLTSQLWASTPMTGMEPWTAARGARTPRARPPARSRPGCRSTARTPTPPRARRSCWPSSPR", "length": 78, "molWeight": 8718, "crc64": "3FF350D3F5242855", "md5": "119E75BAB7A2ACBD87275AC0C44D9E28"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D3A0F3"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7YNC6", "uniProtkbId": "A0AAU7YNC6_LINPO", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Lingulodinium polyedra", "commonName": "Dinoflagellate", "synonyms": ["Gonyaulax polyedra"], "taxonId": 160621, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCA47735.1"}], "lineage": ["Eukaryota", "Sar", "Alveolata", "Dinophyceae", "Gonyaulacales", "Lingulodiniaceae", "Lingulodinium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCA47735.1"}], "value": "Cellulose synthase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCA47735.1"}], "value": "CesA1"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 858, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043493340"}, {"type": "Transmembrane", "location": {"start": {"value": 128, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 650, "modifier": "EXACT"}, "end": {"value": 667, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 679, "modifier": "EXACT"}, "end": {"value": 695, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 715, "modifier": "EXACT"}, "end": {"value": 732, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 753, "modifier": "EXACT"}, "end": {"value": 778, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 798, "modifier": "EXACT"}, "end": {"value": 823, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 835, "modifier": "EXACT"}, "end": {"value": 857, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 85, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 109, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "30941114", "citationType": "journal article", "authors": ["Chan W.S.", "Kwok A.C.M.", "Wong J.T.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "30941114"}], "title": "Knockdown of Dinoflagellate Cellulose Synthase CesA1 Resulted in Malformed Intracellular Cellulosic Thecal Plates and Severely Impeded Cyst-to-Swarmer Transition.", "publicationDate": "2019", "journal": "Front. Microbiol.", "firstPage": "0", "lastPage": "0", "volume": "10"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCA47735.1"}], "value": "CCMP1931", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCA47735.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-9CRH64127A05U", "citationType": "submission", "authors": ["Kwok A.C.M.", "Chan W.S.", "Wong J.T.Y."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCA47735.1"}], "value": "CCMP1931", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCA47735.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP949236", "properties": [{"key": "ProteinId", "value": "XCA47735.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016757", "properties": [{"key": "GoTerm", "value": "F:glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.90.550.10", "properties": [{"key": "EntryName", "value": "Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050321", "properties": [{"key": "EntryName", "value": "Glycosyltr_2/OpgH_subfam"}]}, {"database": "InterPro", "id": "IPR029044", "properties": [{"key": "EntryName", "value": "Nucleotide-diphossugar_trans"}]}, {"database": "PANTHER", "id": "PTHR43867", "properties": [{"key": "EntryName", "value": "CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43867:SF8", "properties": [{"key": "EntryName", "value": "GLYCOSIDE HYDROLASE FAMILY 8"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53448", "properties": [{"key": "EntryName", "value": "Nucleotide-diphospho-sugar transferases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MASSAGCSLSTEARRLPVGSIVCGLLLLVAARAAGPEPLGAAPGLRCAVVACEAVGSAADEAATQGTQGEGLGLLQTRGKRVVAGIPERRSELPNASRTRSSGLLGLNARSNESGSAGPQSASATSRIWLQVVVPVVMGVAAVVVMGVAAASGAVYRPTAQQHMAALGHADKALHGQTSWVEPYQTNALTKMLGAMGALLGPAFLARLYEHRSARFPILARVFLIGEVWNLGLAIVGRVNMWHRQHRHVIRLDCLSPPFPREQWPKVHFFFTHYMEPIEESVEPLVRALQQDYPPDRYVVNILDDSYYKRLSDGSYEIAEIGMEMEDLICRTMAARAGDVKVTRRTVFAEEREDGRPAPAPGGSSVIEFRADGLPLVRVVGRKKGPESFAKAGNLENGLWNILEEDVHFLVVMDSDMAPKPEMLQTLLPPMLAYRNGAWGPDWRTGFVSSPQDFRNVQAVWGADDPCDQMMKFVWRILPTALDHIGLVHFWGTNVGFFVPALKDAGGFVYGCMTEDLVTGAHVHRFGWKSAYVGSVQHSLAKGLCREDVLGTIMQRKRWCQGNIQQLLMEMDPPLILHDSFRYPPHRLEYKAKLQALYDGDSALEPAQALCEADCGAAERRARRTYKWKLLTGFAYFPAKFAFLFHMKPIIYYFLALTIIFIGEPPFRLTGDCFKIAGLYWLANLSANFCTYSAVLDDPDNASSPLWRTQQETYGFAWVRVIGVIEGIWSAITGKQPTWVSFGMNKDSKINMLFHVPNAVAFLFLLTLVIATLLNYFVLARYGLQVPVLCHDVEDAQVLGACSMGVLMLWLLWPVTSCIFADFLGLPYYRLSRILSTFVASSVEVSIGVLFFVAQFLR", "length": 858, "molWeight": 94718, "crc64": "7E7AB382A7F6C75C", "md5": "AFAA4495746BC1453A2A68EFC548BCC6"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 7, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D38F3D"}, "cluster_size": 1, "family": "Lingulodiniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96UUW5", "uniProtkbId": "A0AA96UUW5_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 9, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29085.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29085.1"}], "value": "VWACP-2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 670, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041676447"}, {"type": "Domain", "location": {"start": {"value": 35, "modifier": "EXACT"}, "end": {"value": 212, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 276, "modifier": "EXACT"}, "end": {"value": 450, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Region", "location": {"start": {"value": 222, "modifier": "EXACT"}, "end": {"value": 258, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 222, "modifier": "EXACT"}, "end": {"value": 253, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29085.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651422", "properties": [{"key": "ProteinId", "value": "WNX29085.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "CDD", "id": "cd01472", "properties": [{"key": "EntryName", "value": "vWA_collagen"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.50.410:FF:000004", "properties": [{"key": "EntryName", "value": "collagen alpha-6(VI) chain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PRINTS", "id": "PR00453", "properties": [{"key": "EntryName", "value": "VWFADOMAIN"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MDVKKVAALVFCLVAVHQAGGQDWNHNRQCGQAADMVFVLDMSSSISLTNVKRMLYFVTNVTSQLNVGPGQSQTRVAAVAFSTDVRLEFYLNQYMDKDTLLKKILQIRSKGGNTNTHLALEYVNRHVFQPHRGARPNVSRVVIVITDGVSHKKEATREAAQAVRDNGAKVFAIGVGRQQNRKQLADIASVPADHYVHEVKDFKALAKLKDIVVTRACQVSSSTTTTTTTTTTTTTPSTTTPETSTTTAARSTSPDFPINDSPWQDVNEVCASHPADVYFVLDSSSSIWRYHFENNTLNLVRDIIELYDIGSHHTRVGIITYSDAAEVVFGLNAHLYKDDLLKAVNKDNVKYIPGVTNTSTALKVAGQQLMKEGRDSVQQIIVLVTDGQSNDPKSTMSTARALRDRGVRLLAVGVGDNVDEGELQGVSGEEEVILVGDFQSLEQHSLLLAARSCTPGGNSWIPMRDASSTPSPDYYGSYRRCSLGQADIVWAYDWATLGTRVVSQLSSTLHHLSTTLTQRHADVTMGIMTSHACVRGQKALLPLSSAAIFGKYTRGVVVRSQLHRILKKVRQFAFTAKNGHRPTARKLVVMVLDDASNSPILRQMAIESANMRNEGVEVFLVTSGDHNDDDVLWQEFQLPAPSHVIRLRNLDFSDYGFASDVIAGALCGGW", "length": 670, "molWeight": 73520, "crc64": "2213C5E98C3318F4", "md5": "E273C2A32C3AB92583D3AE378854A6F4"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B32622C"}, "cluster_size": 2, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HCC9", "uniProtkbId": "A0AA96HCC9_9BILA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 9, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Cephalodiscus hodgsoni", "taxonId": 560606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25246.1"}], "lineage": ["Eukaryota", "Metazoa", "Hemichordata", "Pterobranchia", "Cephalodiscida", "Cephalodiscidae", "Cephalodiscus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25246.1"}], "value": "Hypoxia-inducible factor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Domain", "location": {"start": {"value": 90, "modifier": "EXACT"}, "end": {"value": 157, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 242, "modifier": "EXACT"}, "end": {"value": 290, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 28, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25246.1"}], "value": "Cepha1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25246.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354981", "properties": [{"key": "ProteinId", "value": "WNN25246.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005667", "properties": [{"key": "GoTerm", "value": "C:transcription regulator complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "4.10.280.10", "properties": [{"key": "EntryName", "value": "Helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR001067", "properties": [{"key": "EntryName", "value": "Nuc_translocat"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23171", "properties": [{"key": "EntryName", "value": "bHLH_HIF1A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14598", "properties": [{"key": "EntryName", "value": "PAS_11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00785", "properties": [{"key": "EntryName", "value": "NCTRNSLOCATR"}]}, {"database": "SMART", "id": "SM00353", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MKTEIRTKSKRRNSEKRKERSRNAARSRRGKETDLFYELAQELPVSCSVCSQLDKAGIMRMVLSYLKIRNLFSDCDVERALKQLSKDTVAEESYLKALDGFLVVLTQEGSIAYVSDNVSRYLGLKQVDLTGSSLYEYSHPCDHDEVRDELETKNDRHAGSHKAAHSFLVRMKCTLQPNGKKVNLKAAAYKAIHFRGHSVMAHADQSQAGHEELYTVLVGEPIPHPANIEVPLDSKTFVTKHNLDMTFTYCDERVKDLLGYDPEELLGRSVYKFQHGLDTNHLKKTFHQRK", "length": 290, "molWeight": 33132, "crc64": "CF7BFD0B6B961ACE", "md5": "1834BDC11CADB19B591C6EC5949E4080"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 1}, "uniParcId": "UPI002B2AC674"}, "cluster_size": 1, "family": "Cephalodiscidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7Z6", "uniProtkbId": "A0AAN0N7Z6_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65881.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65881.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65881.1"}], "value": "UGT"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009995"}], "value": "Belongs to the UDP-glycosyltransferase family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65881.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145334", "properties": [{"key": "ProteinId", "value": "WRV65881.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050271", "properties": [{"key": "EntryName", "value": "UDP-glycosyltransferase"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48043", "properties": [{"key": "EntryName", "value": "EG:EG0003.4 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48043:SF145", "properties": [{"key": "EntryName", "value": "FI06409P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00201", "properties": [{"key": "EntryName", "value": "UDPGT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEQVKKDVLLIIPLLTQGHTNVCAAIGKKFLEKYGSTIDVYFMVDEEYKTKLSKIDQNFKFSLLSDFFDKAMDTFLEKKEEKNTHYILDSFREFGKLWHLDTKEYIQKSTYLFTLDFEAMNNNYDQMTEMIKKLKPKFIILDNLFSYPLGVDQGIPYANLLSSAITYFGHDQLPPPQSSLPSEYTPENLKLWKEFIDATYKVGNFKELKDKINEKLKLHNCPNLDDKYFLYKESKYLNIYNYPKFLDYENENIKYPGPWFRIQSSIIKPIPDPYPVILKDLPGKLIYFSLGSMASVYKPLMEKILSILSQIPHRFIVSTGMVGEQYELSKNMHGEKFVNQLAALQTVDIVISHGGNNTLTEAFYFGKPLVVMPLFGDQKDNAFRVDEIGLGKKINTFNFTKEEMENAIEYCLKDEVIEKMKLCSQLIQNDNSLDLLCEEVKKYF", "length": 444, "molWeight": 51742, "crc64": "8A0F25178D006681", "md5": "BD60D3BA37E9D319BD974CD57C6E7DBB"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0032516201"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MMD2", "uniProtkbId": "A0AA96MMD2_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50066.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50066.1"}], "value": "Uncharacterized protein 12"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 223, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041722716"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50066.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460143", "properties": [{"key": "ProteinId", "value": "WNS50066.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MVGLFGQLCFLAMLATGLSKCNKTSPPYIDTGDLATIYPIGRVCTSGYDQRWLTLVFDYCKSHYGPTVVLAGPRPVYQHWVKVFNGKLTAKSQFHLVSFPFLDYALKVSDTTPFGATGNTKVITAAKLPAGFYHSTNGGPFRQLTDDFLFTDMVAYTDGTISGTWNHVQHVSTGLYLKALLDHPAQCGTKYDPVVCSGVKTYDDMTSKTCSCIVEWPLWRYHD", "length": 223, "molWeight": 24722, "crc64": "CB53440687946855", "md5": "3996ED1C2ACBCFDF5F2C4B04A331CF48"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B2A3614"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEN7", "uniProtkbId": "A0AB38ZEN7_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02756.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02756.1"}], "value": "Venom CUB domain protein 4"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 15, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 145, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044277559"}, {"type": "Domain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 132, "modifier": "EXACT"}}, "description": "CUB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS01180"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 145, "modifier": "EXACT"}, "end": {"value": 145, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02756.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02756.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517506", "properties": [{"key": "ProteinId", "value": "WXI02756.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd00041", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.290", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000859", "properties": [{"key": "EntryName", "value": "CUB_dom"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24251", "properties": [{"key": "EntryName", "value": "OVOCHYMASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00431", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00042", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01180", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQLVGVVILAVLAAAEDQEMDEVIQLEAGGKPYTFTSENYPLQPPDNFNQNWHFSTSPGSTIRVTCSDFRLVQKSETECTEETVTFTDGVKSEEVCGTRYGYTVLSSNNQMSVMFKTGMYGRGSFKCVAQGRQMDRYGEVTTTPL", "length": 145, "molWeight": 16108, "crc64": "701E85C8F08EB67F", "md5": "21D4398134C113783FB9D887AEB5313E"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Disulfide bond": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388BCC38"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZET4", "uniProtkbId": "A0AB38ZET4_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02769.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02769.1"}], "value": "Venom Ptu1 family peptide Os1a"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044325048"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02769.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517519", "properties": [{"key": "ProteinId", "value": "WXI02769.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MKHLLLLLFFIVSVLVVAQSHPGFVEPDEAPPGCIPAGEKCSLMSMYKCCLPAICNEITSECI", "length": 63, "molWeight": 6838, "crc64": "232967979029FB37", "md5": "0FF051601DF00C8E5299018441D6F382"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C28B4"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTS4", "uniProtkbId": "A0AAT9UTS4_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41624.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41624.1"}], "value": "Cytochrome P450 6PZ17"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 450, "modifier": "EXACT"}, "end": {"value": 450, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41624.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117184", "properties": [{"key": "ProteinId", "value": "WIM41624.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000042", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYTKFLLFFATVFLVYIYYRLNKLYSYFERNGIPYIKPILLLGNTKDWIFMKKALSMVYYDVYEKLDPHRFCGVFVGWRKVILVRDPELIRNILVKDFSYFYNREVEPTPKTDFLNENLMEMRGDEWKTLRAKLTTTFTPVKMKDMYPLIQDCGKKLHFILHNLVNKDILIKDICARYTTDVIGICAFGLNINSLNDPDSIFTQMGNRVLETSFINTLRAAFPKLDLFFDPFGSDNILQAFFLNFVKDTVQHRLDHKIVRGDLLDLLISLKLDADSHKSKQCHLAHQKNHTSIEMTDELMTAQCFAYFIGSFATSSSALSYMLLELAQNQHIQDKLRNEIITVLENNNNELTYEAMKQLKYMDMVIDETLRKYPVAGNICRACCKPYQIPDSEFVIPERTKIVISIRGIHYDPKYYEKPLEFYPEHFTEKAKARRPHFTFLPFGGGPRICIGERFAKMQIKVGAVNLLKDLSYHVSPKMKFPIEHAPGLFLFNVKGGIWLRCEKL", "length": 505, "molWeight": 59037, "crc64": "B59A176A4683369D", "md5": "CE051164C581252A3B8ACC07FFEBA25E"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D37A9F"}, "cluster_size": 5, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEE3", "uniProtkbId": "A0AB38ZEE3_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00902.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00902.1"}], "value": "Venom peptide Es1a"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044280062"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022854"}], "id": "KW-0960", "category": "Domain", "name": "Knottin"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022656"}], "id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00902.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-RUDT4T1F4QC9", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00902.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP516297", "properties": [{"key": "ProteinId", "value": "WXI00902.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0019855", "properties": [{"key": "GoTerm", "value": "F:calcium channel inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR012325", "properties": [{"key": "EntryName", "value": "Assassin_bug_toxin-like"}]}, {"database": "Pfam", "id": "PF08117", "properties": [{"key": "EntryName", "value": "Toxin_30"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57059", "properties": [{"key": "EntryName", "value": "omega toxin-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS60010", "properties": [{"key": "EntryName", "value": "ASSASSIN_BUG_TOXIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKFLAILFLVIITYLSLAFGAEKDCIPLGAPCFGTDKPCCEPRTWCSPYANKCL", "length": 54, "molWeight": 5974, "crc64": "45F766E7FDAC63C5", "md5": "BC724DC6D5201C6A809E3FBC3EED7788"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BC4E4"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJK2", "uniProtkbId": "A0AAU7LJK2_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28268.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28268.1"}], "value": "MADS73"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28268.1"}], "value": "MADS73"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 42, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28268.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28268.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400908", "properties": [{"key": "ProteinId", "value": "XBP28268.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00266", "properties": [{"key": "EntryName", "value": "MADS_SRF_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR033897", "properties": [{"key": "EntryName", "value": "SRF-like_MADS-box"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR11945", "properties": [{"key": "EntryName", "value": "MADS BOX PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11945:SF534", "properties": [{"key": "EntryName", "value": "MYOCYTE-SPECIFIC ENHANCER FACTOR 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MELIANEKTRKTTFQKRKKGLMKKAYEFSTLCDVDVCVILYTPDDLKVAKTESQLHTTWPSNPIEVKRIISKFDFINKHKPTKINACDVFDILSERKRRVAIDISKSRKAFYASKYPTWHEILNHYSNDQMGLLLNRLDSNIEALGRLIDFKKEVKEAIKTSTCLFSSNQNRVDFYKHQVLFHNPSYIQHPIHNFNRVLDHSDLNQTMPLTSGGDQTFNYDPTAPYIQHPIHSFNHVLDHMQLLPPSDLNQTMPLTSGGDLSFNYDPKAPGVLMGSAYMPMMLNNGATSTSDANQQYFGMLDSAVNYSQYPILPSISTQQMHDSEGNDSSYIYIN", "length": 335, "molWeight": 38372, "crc64": "71989865B0EBC900", "md5": "6D20FBEC6836DD07D8AB65A8E7DB93F3"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D370D1"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0PAB7", "uniProtkbId": "A0AAF0PAB7_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paratelphusula gibbosa", "taxonId": 511413, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69272.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Paratelphusula"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69272.1"}], "value": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69272.1"}], "value": "scaffold930585"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 28, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 68, "modifier": "EXACT"}, "end": {"value": 104, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 106, "modifier": "EXACT"}, "end": {"value": 142, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 144, "modifier": "EXACT"}, "end": {"value": 180, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 56, "modifier": "EXACT"}, "end": {"value": 65, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 94, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 132, "modifier": "EXACT"}, "end": {"value": 141, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 170, "modifier": "EXACT"}, "end": {"value": 179, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69272.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 227, "modifier": "EXACT"}, "end": {"value": 227, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69272.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022536"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-0245", "category": "Domain", "name": "EGF-like domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69272.1"}], "value": "S85", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69272.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69272.1"}], "value": "S85", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69272.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR517325", "properties": [{"key": "ProteinId", "value": "WMS69272.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005509", "properties": [{"key": "GoTerm", "value": "F:calcium ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005112", "properties": [{"key": "GoTerm", "value": "F:Notch binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007219", "properties": [{"key": "GoTerm", "value": "P:Notch signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00054", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000123", "properties": [{"key": "EntryName", "value": "Crumbs homolog 1 (Drosophila)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000122", "properties": [{"key": "EntryName", "value": "Protein crumbs homolog 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000472", "properties": [{"key": "EntryName", "value": "Uncharacterized protein, isoform A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000649", "properties": [{"key": "EntryName", "value": "Uncharacterized protein, isoform A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.10.25.10", "properties": [{"key": "EntryName", "value": "Laminin"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "InterPro", "id": "IPR001881", "properties": [{"key": "EntryName", "value": "EGF-like_Ca-bd_dom"}]}, {"database": "InterPro", "id": "IPR013032", "properties": [{"key": "EntryName", "value": "EGF-like_CS"}]}, {"database": "InterPro", "id": "IPR000742", "properties": [{"key": "EntryName", "value": "EGF-like_dom"}]}, {"database": "InterPro", "id": "IPR000152", "properties": [{"key": "EntryName", "value": "EGF-type_Asp/Asn_hydroxyl_site"}]}, {"database": "InterPro", "id": "IPR018097", "properties": [{"key": "EntryName", "value": "EGF_Ca-bd_CS"}]}, {"database": "InterPro", "id": "IPR009030", "properties": [{"key": "EntryName", "value": "Growth_fac_rcpt_cys_sf"}]}, {"database": "PANTHER", "id": "PTHR12916", "properties": [{"key": "EntryName", "value": "CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12916:SF4", "properties": [{"key": "EntryName", "value": "UNINFLATABLE, ISOFORM C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00008", "properties": [{"key": "EntryName", "value": "EGF"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Pfam", "id": "PF12661", "properties": [{"key": "EntryName", "value": "hEGF"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PRINTS", "id": "PR00010", "properties": [{"key": "EntryName", "value": "EGFBLOOD"}]}, {"database": "SMART", "id": "SM00181", "properties": [{"key": "EntryName", "value": "EGF"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "SMART", "id": "SM00179", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "SUPFAM", "id": "SSF57196", "properties": [{"key": "EntryName", "value": "EGF/Laminin"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF57184", "properties": [{"key": "EntryName", "value": "Growth factor receptor domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00010", "properties": [{"key": "EntryName", "value": "ASX_HYDROXYL"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS00022", "properties": [{"key": "EntryName", "value": "EGF_1"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "PROSITE", "id": "PS01186", "properties": [{"key": "EntryName", "value": "EGF_2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50026", "properties": [{"key": "EntryName", "value": "EGF_3"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "PROSITE", "id": "PS01187", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "CMNGAACIDGVNDFSCTCKPGWTGKRCDTDIGGCDSLPCLNAAQCINLFEDYFCVCPSGTDGKRCQVTPERCVGNPCMNGATCQDYGSGLNCTCSRDFIGVGCEYEFDACEAGLCKNGATCIDRGAGYECVCPPGYTGTNCDLDIQDCTQTSCPPGATCIDLTNDFYCKCPFNLTGEDCRKVINIDYELYINDESKASSASLATPFELGEPTSFTIAFWVQFAVQDD", "length": 227, "molWeight": 24323, "crc64": "121BFD6530AEE176", "md5": "EC86B841F6B919F7C93683002BD17B31"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Domain": 5, "Disulfide bond": 5, "Non-terminal residue": 2}, "uniParcId": "UPI002B29AB9D"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P6P4", "uniProtkbId": "A0AAF0P6P4_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paratelphusula gibbosa", "taxonId": 511413, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59213.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Paratelphusula"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59213.1"}], "value": "Fukutin-related protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59213.1"}], "value": "scaffold1786417"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59213.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 243, "modifier": "EXACT"}, "end": {"value": 243, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59213.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59213.1"}], "value": "S85", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59213.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59213.1"}], "value": "S85", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59213.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515336", "properties": [{"key": "ProteinId", "value": "WMS59213.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR052613", "properties": [{"key": "EntryName", "value": "LicD_transferase"}]}, {"database": "PANTHER", "id": "PTHR13627", "properties": [{"key": "EntryName", "value": "FUKUTIN RELATED PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13627:SF34", "properties": [{"key": "EntryName", "value": "RIBITOL-5-PHOSPHATE TRANSFERASE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VRLSGSLVVLCPDVMFFVDEAPAMAREDWLEVASRWAIQDVWPHDGGKLEFTCKEIGIECVNIMKMVSSFLVPPCCREALRYELGLVQECGEELGAYVELQAGSLLGAVKTDGILPWDFDMDVLGDCKYKKDWMEKGMECMSRKGCSSVHIAGSYWMTTCNVSFVDVSCKPDQLTLLPPEYRDVPTRVNYSGRMIFVPPNPALVARNTYGPEYLRHEVHWRYTGKDKGVWNRCSAPGFHACLE", "length": 243, "molWeight": 27420, "crc64": "FC36EC777B3C3BEF", "md5": "22A97551379DE5DADA680AB7EDC6D020"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI002B2F920E"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MNW2", "uniProtkbId": "A0AA96MNW2_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50110.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50110.1"}], "value": "Insulin-like protein receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 750, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041655739"}, {"type": "Transmembrane", "location": {"start": {"value": 447, "modifier": "EXACT"}, "end": {"value": 475, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 32, "modifier": "EXACT"}, "end": {"value": 122, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Domain", "location": {"start": {"value": 324, "modifier": "EXACT"}, "end": {"value": 416, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Region", "location": {"start": {"value": 410, "modifier": "EXACT"}, "end": {"value": 435, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 481, "modifier": "EXACT"}, "end": {"value": 504, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 554, "modifier": "EXACT"}, "end": {"value": 730, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 418, "modifier": "EXACT"}, "end": {"value": 435, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 554, "modifier": "EXACT"}, "end": {"value": 565, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 609, "modifier": "EXACT"}, "end": {"value": 618, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 660, "modifier": "EXACT"}, "end": {"value": 683, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 707, "modifier": "EXACT"}, "end": {"value": 727, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50110.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50110.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460187", "properties": [{"key": "ProteinId", "value": "WNS50110.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005005", "properties": [{"key": "GoTerm", "value": "F:transmembrane-ephrin receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00063", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050449", "properties": [{"key": "EntryName", "value": "Ephrin_rcpt_TKs"}]}, {"database": "InterPro", "id": "IPR003961", "properties": [{"key": "EntryName", "value": "FN3_dom"}]}, {"database": "InterPro", "id": "IPR036116", "properties": [{"key": "EntryName", "value": "FN3_sf"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "PANTHER", "id": "PTHR46877", "properties": [{"key": "EntryName", "value": "EPH RECEPTOR A5"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46877:SF9", "properties": [{"key": "EntryName", "value": "EPHRIN TYPE-A RECEPTOR 7"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00041", "properties": [{"key": "EntryName", "value": "fn3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00060", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49265", "properties": [{"key": "EntryName", "value": "Fibronectin type III"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50853", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIKELLILYLLAVTTHGTSSLQVNLTVVIDGYTVNSTLTSSATLPLGRTALLVCRVSGIPHGQQTSYQWTCPNQPCVQTGYAGRKISNNIIAINTTSTSDGGTYTCTVTAGGMKGRQDFGINVNGGAVAHSYGRLLENEAVITNKRQLQPPNADTGDGRIECTISGGMSRFSFSPYRVDSGNTQKATAVIPSKAFGRFNNIDGSCGNTFLYLYLNKTDGFPQVRSLTPSTDSRQSTITANMEFTYDMSNGIGRVITGYHRLDLGHEMVGQFHNNGMKKKLMFSALVPGARYRITAWGLGGGPNKKRGSAPAVLEVTTQPSDPSPPRALTITTVLEDGIELNWLPPRKSNGDIQHYIIRYTLQNGTGQRITTTDNINYYNLTGLEGGQTYYNFTVEAANLAHTSAQSNTIESYTHSPDSSNTLTTKSGTSTATIPTTTSITEPQGSSILYIGSGAGSLLLVLVAVLAVIICCVVAVHRRGKRSRSTDHTPTLHYYSTPGHEQEEEPQVQIGADNYDTVGENASFTPGTLYDEVEVKIVKPKPVAVPSEYQLPLVEADKEDDKEAHDTVTIPESFYAQPDTTAKSNKKGEKGTTADVEDPDVLYAEVDKPKKPKKKKKGKEKKEEHPQGDLYAVVDKTSKQKGKEKKIKEKEQQGDGDLYAEVDKTQKKGKNDMEEKASFVREQSDSPPPVPQYRMAYEPSADSCLFLNNNNNSNNSNSNNSNNNNNNNGRAVTLGHTIMMARSTQKISTKH", "length": 750, "molWeight": 81630, "crc64": "F9B072886DE567C5", "md5": "4E10537EACE4A1B07B3F9D0103CF9BDF"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 2, "Region": 3, "Compositional bias": 5}, "uniParcId": "UPI002B2A6ACD"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LM86", "uniProtkbId": "A0AAN0LM86_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34098.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34098.1"}], "value": "Serotonin receptor-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 49, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 169, "modifier": "EXACT"}, "end": {"value": 197, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 209, "modifier": "EXACT"}, "end": {"value": 227, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 247, "modifier": "EXACT"}, "end": {"value": 268, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 289, "modifier": "EXACT"}, "end": {"value": 310, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 330, "modifier": "EXACT"}, "end": {"value": 353, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 189, "modifier": "EXACT"}, "end": {"value": 362, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34098.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155024", "properties": [{"key": "ProteinId", "value": "WRW34098.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004993", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled serotonin receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0071880", "properties": [{"key": "GoTerm", "value": "P:adenylate cyclase-activating adrenergic receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043410", "properties": [{"key": "GoTerm", "value": "P:positive regulation of MAPK cascade"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24248", "properties": [{"key": "EntryName", "value": "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24248:SF199", "properties": [{"key": "EntryName", "value": "IP13425P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSFKEFNYLKIFKQSFRTAKQFDKSFFCILNKTFILTFMIINFICITLVSSKTIKIKYFDYPFFKQNLENKLVNGFVDSKEIFIFTNNTISSVPQNLNKTISVIENNILKYSNKKTNVRNVKNLNNNSNEFKQIFSSTNELIENSTKINNSSKTKFLEGSNSSPNHYSLLMKIVICLILIVLILLTIVGNIFVIVAICLDKNLQSAQNYLVLSLAVADLTVAILVMPLCAHMEILQRWTLGSELCTFWNLIDVFSCTASILHLLGIALDRYWSVSSLHYSQRRSLQRMMYLIAAIWLAAAVISMPPLLGVKDPEYANRVKNGQCLMSQDVGYQIFATFSTFYLPCAVILLLYWKIYKLSRKP", "length": 362, "molWeight": 41544, "crc64": "F3D33CFD851BA3C6", "md5": "CF03F59B72B4CF5ABEF59C0A35B47B9D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6, "Domain": 1}, "uniParcId": "UPI00324FC559"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7PIV5", "uniProtkbId": "A0AAU7PIV5_9MAGN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Asarum sieboldii", "taxonId": 76098, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS51825.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Magnoliidae", "Piperales", "Asaraceae", "Asarum"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS51825.1"}], "value": "Cytochrome P450 CYP719A3"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS51825.1"}], "value": "1.14.19.68"}]}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 443, "modifier": "EXACT"}, "end": {"value": 443, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS51825.1"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8CGUL9EAQV1PQ", "citationType": "submission", "authors": ["Ji P.", "Liu Z."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS51825.1"}], "value": "Whole plant", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS51825.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP908980", "properties": [{"key": "ProteinId", "value": "XBS51825.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "PANTHER", "id": "PTHR24281", "properties": [{"key": "EntryName", "value": "STEROID 21-HYDROXYLASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MENLNIWVAFLTTALAVFFEAFRRLQSRRKPAATLVGWPVGPRRLPIIGNLHQLAKGGDLVHRALANLARVHGRVMTIWLGSWTPMIVVSDSELVWEVLVGKSSDYASRALPSISKFINADFRSVATSDMGPHWHSLRRGLQNGPLGPANVAAQAHLQEGDVAALIQTLKKEATQSDDGVVWPFGPIRHTTIRLLARLCFGADFDDEEFVKAMDRVVEDTISITGHGRLVDAFAFARFLPSVRRTFQQTLHVKRKIEEVIRPHLSPSPPQNSFLDVLLSQNLPEEVTIFCIFEVFLLGVDSTASTTAWALAFLIHHQDVQEKLHREISDYHRKEGGKKIVKAEDVSKLQYLQAVVKETMRMKPIAPLAVPHKTTKDTKLNGRSVGKGTQVVVNIYSVHYDPKVWTEPERFSPERFLAGGVKQGKNEKLQDQSFIPFGGGMRTCAGMELGKLQVALAVANLVGAFRWAPAVASELPDMSEEMTFVLMMKNPLAARIMVHDE", "length": 500, "molWeight": 55697, "crc64": "065857893E807A36", "md5": "E3DB042460190B0F81902AF759E5AC31"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D2CBFD"}, "cluster_size": 3, "family": "Asaraceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38YKR9", "uniProtkbId": "A0AB38YKR9_9TRYP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Blastocrithidia nonstop", "taxonId": 2592485, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58453.1"}], "lineage": ["Eukaryota", "Discoba", "Euglenozoa", "Kinetoplastea", "Metakinetoplastina", "Trypanosomatida", "Trypanosomatidae", "Blastocrithidia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003375"}], "value": "Cytochrome c oxidase subunit 3"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58453.1"}], "value": "COIII"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003375"}], "value": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003375"}], "value": "Belongs to the cytochrome c oxidase subunit 3 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 43, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 49, "modifier": "EXACT"}, "end": {"value": 68, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 80, "modifier": "EXACT"}, "end": {"value": 104, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 110, "modifier": "EXACT"}, "end": {"value": 133, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 140, "modifier": "EXACT"}, "end": {"value": 168, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 174, "modifier": "EXACT"}, "end": {"value": 193, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 225, "modifier": "EXACT"}, "end": {"value": 246, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 280, "modifier": "EXACT"}}, "description": "Heme-copper oxidase subunit III family profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50253"}]}], "geneLocations": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58453.1"}], "geneEncodingType": "Mitochondrion"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003375"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58453.1"}], "id": "KW-0496", "category": "Cellular component", "name": "Mitochondrion"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003375"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FDG24681IABBA", "citationType": "submission", "authors": ["Afonin D.A."], "publicationDate": "APR-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58453.1"}], "value": "P57", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58453.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ911728", "properties": [{"key": "ProteinId", "value": "WLJ58453.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005739", "properties": [{"key": "GoTerm", "value": "C:mitochondrion"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004129", "properties": [{"key": "GoTerm", "value": "F:cytochrome-c oxidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0022904", "properties": [{"key": "GoTerm", "value": "P:respiratory electron transport chain"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.20.120.80", "properties": [{"key": "EntryName", "value": "Cytochrome c oxidase, subunit III, four-helix bundle"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000298", "properties": [{"key": "EntryName", "value": "Cyt_c_oxidase-like_su3"}]}, {"database": "InterPro", "id": "IPR035973", "properties": [{"key": "EntryName", "value": "Cyt_c_oxidase_su3-like_sf"}]}, {"database": "InterPro", "id": "IPR013833", "properties": [{"key": "EntryName", "value": "Cyt_c_oxidase_su3_a-hlx"}]}, {"database": "Pfam", "id": "PF00510", "properties": [{"key": "EntryName", "value": "COX3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81452", "properties": [{"key": "EntryName", "value": "Cytochrome c oxidase subunit III-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50253", "properties": [{"key": "EntryName", "value": "COX3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLFFRVLYLGCSNIFLFLSIPAILLFLYVLFIIEFVIICFWSFLYVDFFLLWFLFGLFFFVFCLWSDFSFDYFRSNDNFIFLRCVQYCFILFFLSEFILFVTFFYCVFGYVIFCVLEFCFVFCLPFLICFCIVDFGFISYWFFIDFFLIMMNTFYLFLGGLFVNLLFFSFYFRLHFFSCLICVWVLLFGYLFIWNQSYDFNLLYCTISCGIFGSILFVIDILHFTHVLIGIFFFGFSYFRFFIYVVMDLRFVFLVVVIFYWHFVDVVWFFLLRFCYYFINLFWYECYLIIFF", "length": 292, "molWeight": 36220, "crc64": "4A83D5CC2480A24A", "md5": "B5145E8E8396576AC1996E97F1E71D5F"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI00388C1E7A"}, "cluster_size": 1, "family": "Trypanosomatidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9FG57", "uniProtkbId": "A0AAT9FG57_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Enchytraeus japonensis", "taxonId": 228735, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61260.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61260.1"}], "value": "Matrix metalloproteinase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61260.1"}], "value": "Ej-MMPreg"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Ca(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29108"}}], "note": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "value": "Can bind about 5 Ca(2+) ions per subunit."}]}}, {"commentType": "COFACTOR", "cofactors": [{"name": "Zn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29105"}}], "note": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "value": "Binds 2 Zn(2+) ions per subunit."}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010370"}], "value": "Belongs to the peptidase M10A family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 652, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043972475"}, {"type": "Transmembrane", "location": {"start": {"value": 630, "modifier": "EXACT"}, "end": {"value": 648, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 165, "modifier": "EXACT"}, "end": {"value": 324, "modifier": "EXACT"}}, "description": "Peptidase metallopeptidase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00235"}]}, {"type": "Repeat", "location": {"start": {"value": 406, "modifier": "EXACT"}, "end": {"value": 454, "modifier": "EXACT"}}, "description": "Hemopexin", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01011"}]}, {"type": "Repeat", "location": {"start": {"value": 458, "modifier": "EXACT"}, "end": {"value": 507, "modifier": "EXACT"}}, "description": "Hemopexin", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01011"}]}, {"type": "Repeat", "location": {"start": {"value": 509, "modifier": "EXACT"}, "end": {"value": 556, "modifier": "EXACT"}}, "description": "Hemopexin", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01011"}]}, {"type": "Repeat", "location": {"start": {"value": 557, "modifier": "EXACT"}, "end": {"value": 604, "modifier": "EXACT"}}, "description": "Hemopexin", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01011"}]}, {"type": "Region", "location": {"start": {"value": 327, "modifier": "EXACT"}, "end": {"value": 352, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 329, "modifier": "EXACT"}, "end": {"value": 343, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Active site", "location": {"start": {"value": 280, "modifier": "EXACT"}, "end": {"value": 280, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR001191-1"}]}, {"type": "Binding site", "location": {"start": {"value": 184, "modifier": "EXACT"}, "end": {"value": 184, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 218, "modifier": "EXACT"}, "end": {"value": 218, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "2"}}, {"type": "Binding site", "location": {"start": {"value": 228, "modifier": "EXACT"}, "end": {"value": 228, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 230, "modifier": "EXACT"}, "end": {"value": 230, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 235, "modifier": "EXACT"}, "end": {"value": 235, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "3"}}, {"type": "Binding site", "location": {"start": {"value": 236, "modifier": "EXACT"}, "end": {"value": 236, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "3"}}, {"type": "Binding site", "location": {"start": {"value": 243, "modifier": "EXACT"}, "end": {"value": 243, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 252, "modifier": "EXACT"}, "end": {"value": 252, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "2"}}, {"type": "Binding site", "location": {"start": {"value": 254, "modifier": "EXACT"}, "end": {"value": 254, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "2"}}, {"type": "Binding site", "location": {"start": {"value": 256, "modifier": "EXACT"}, "end": {"value": 256, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 258, "modifier": "EXACT"}, "end": {"value": 258, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "3"}}, {"type": "Binding site", "location": {"start": {"value": 261, "modifier": "EXACT"}, "end": {"value": 261, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "3"}}, {"type": "Binding site", "location": {"start": {"value": 261, "modifier": "EXACT"}, "end": {"value": 261, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 279, "modifier": "EXACT"}, "end": {"value": 279, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR001191-2"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "label": "2", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 283, "modifier": "EXACT"}, "end": {"value": 283, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR001191-2"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "label": "2", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 289, "modifier": "EXACT"}, "end": {"value": 289, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR001191-2"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "label": "2", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 297, "modifier": "EXACT"}, "end": {"value": 297, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "label": "2", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 414, "modifier": "EXACT"}, "end": {"value": 414, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "4"}}, {"type": "Binding site", "location": {"start": {"value": 416, "modifier": "EXACT"}, "end": {"value": 416, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "5"}}, {"type": "Binding site", "location": {"start": {"value": 462, "modifier": "EXACT"}, "end": {"value": 462, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "4"}}, {"type": "Binding site", "location": {"start": {"value": 515, "modifier": "EXACT"}, "end": {"value": 515, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108", "label": "5"}}, {"type": "Modified residue", "location": {"start": {"value": 493, "modifier": "EXACT"}, "end": {"value": 493, "modifier": "EXACT"}}, "description": "Phosphotyrosine; by PKDCC", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-4"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR621190-2"}], "id": "KW-0106", "category": "Ligand", "name": "Calcium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR001191-2"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023049"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61260.1"}], "id": "KW-0482", "category": "Molecular function", "name": "Metalloprotease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR001191-2"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023145"}], "id": "KW-0865", "category": "PTM", "name": "Zymogen"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1NS4NNSF9REKQ", "citationType": "submission", "authors": ["Yamaguchi S.", "Fujita T."], "title": "Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61260.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC727633", "properties": [{"key": "ProteinId", "value": "BDR61260.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0031012", "properties": [{"key": "GoTerm", "value": "C:extracellular matrix"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004222", "properties": [{"key": "GoTerm", "value": "F:metalloendopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0030574", "properties": [{"key": "GoTerm", "value": "P:collagen catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030198", "properties": [{"key": "GoTerm", "value": "P:extracellular matrix organization"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00094", "properties": [{"key": "EntryName", "value": "HX"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd04278", "properties": [{"key": "EntryName", "value": "ZnMc_MMP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.110.10.10:FF:000018", "properties": [{"key": "EntryName", "value": "Matrix metallopeptidase 25b"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.390.10", "properties": [{"key": "EntryName", "value": "Collagenase (Catalytic Domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.110.10.10", "properties": [{"key": "EntryName", "value": "Hemopexin-like domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000585", "properties": [{"key": "EntryName", "value": "Hemopexin-like_dom"}]}, {"database": "InterPro", "id": "IPR036375", "properties": [{"key": "EntryName", "value": "Hemopexin-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR018487", "properties": [{"key": "EntryName", "value": "Hemopexin-like_repeat"}]}, {"database": "InterPro", "id": "IPR033739", "properties": [{"key": "EntryName", "value": "M10A_MMP"}]}, {"database": "InterPro", "id": "IPR024079", "properties": [{"key": "EntryName", "value": "MetalloPept_cat_dom_sf"}]}, {"database": "InterPro", "id": "IPR001818", "properties": [{"key": "EntryName", "value": "Pept_M10_metallopeptidase"}]}, {"database": "InterPro", "id": "IPR021190", "properties": [{"key": "EntryName", "value": "Pept_M10A"}]}, {"database": "InterPro", "id": "IPR006026", "properties": [{"key": "EntryName", "value": "Peptidase_Metallo"}]}, {"database": "InterPro", "id": "IPR002477", "properties": [{"key": "EntryName", "value": "Peptidoglycan-bd-like"}]}, {"database": "InterPro", "id": "IPR036365", "properties": [{"key": "EntryName", "value": "PGBD-like_sf"}]}, {"database": "PANTHER", "id": "PTHR10201", "properties": [{"key": "EntryName", "value": "MATRIX METALLOPROTEINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10201:SF291", "properties": [{"key": "EntryName", "value": "MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00045", "properties": [{"key": "EntryName", "value": "Hemopexin"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Pfam", "id": "PF00413", "properties": [{"key": "EntryName", "value": "Peptidase_M10"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01471", "properties": [{"key": "EntryName", "value": "PG_binding_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF001191", "properties": [{"key": "EntryName", "value": "Peptidase_M10A_matrix"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00138", "properties": [{"key": "EntryName", "value": "MATRIXIN"}]}, {"database": "SMART", "id": "SM00120", "properties": [{"key": "EntryName", "value": "HX"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SMART", "id": "SM00235", "properties": [{"key": "EntryName", "value": "ZnMc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50923", "properties": [{"key": "EntryName", "value": "Hemopexin-like domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55486", "properties": [{"key": "EntryName", "value": "Metalloproteases ('zincins'), catalytic domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47090", "properties": [{"key": "EntryName", "value": "PGBD-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51642", "properties": [{"key": "EntryName", "value": "HEMOPEXIN_2"}, {"key": "MatchStatus", "value": "4"}]}], "sequence": {"value": "MFWCQVMALLGSCVMTHPLEKSYGYDLSGGNNDGGSIKKYQKEFELRHMDGTTYLSRYGYLPGSDLETGALRTEDELIRAVTLFQRHAHIPQTGRLDDATVKMMKEPRCGVIDAIHDHRNSAHNQNRHSGRGRRGAETLGGLKPIITLSRETREALEEPQQYVLGPSSWKKKYLTFRILNYTPDLSYEETRDAIIRAFYLWSDVTPLSFHEIQSGDADIYIQFSSGYHQDGYTFDGPGMVLAHAFFPGEGRGGDIHFDEDERWTVRTKEGVNLYAVMAHELGHSLGLAHSYVQGSLMFPWHRGYDPDLKLHQDDIQAIQLLYGVREKAPPPPVTPHPKLPTAPPTSTTTKPTTTTRAIRRFTINLNPVTMAPVTRAFVPIEPVTKATVPKVPPTKEKANTDPDRAPDKCSVTLDAISLIRGEVFAFSGKWFWRLSADGVMAGYPIQISRFWFGLPRDLTRVDAVVERPNNGHILFFSGARYFEFYGNSLLPGYSPNGRPISELGLPSDLDGVDAAFVWAHNRRIYIIKDTMYWRLDDGGRSVDHGYPRDMSMWGGVPLPVSAAFTHTDRHTYFFHGRDYYEFNNIRMRVKPGYPKPMTSRWLGCDVTDDSPSVSRRDSLLMTNMADTTRASLFVFIIVGLNLLTVFRISKIL", "length": 652, "molWeight": 73726, "crc64": "899B76F6A5AD935F", "md5": "6A13D60E32DF43181E9FE689D0D5A59B"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 2, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 1, "Repeat": 4, "Region": 1, "Compositional bias": 1, "Active site": 1, "Binding site": 21, "Modified residue": 1}, "uniParcId": "UPI0035D2C87C"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLQ9", "uniProtkbId": "A0AAU0QLQ9_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56493.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56493.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 30, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56493.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56493.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56493.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56493.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970386", "properties": [{"key": "ProteinId", "value": "WPO56493.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VLITEPDVPTKILHFFRMVSVSLTIFIYTWPAEVLSEANADLAQAAYKSLWYISDVRTRRLSLLIMQRSVHPVYLKALSFWNIKLETYTKIMSSAYSYISVLSTANN", "length": 107, "molWeight": 12322, "crc64": "0D188BF98B861C0C", "md5": "1971C037321862E9E9278AE597CFA95D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 1}, "uniParcId": "UPI003093872C"}, "cluster_size": 2, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7J8Q2", "uniProtkbId": "A0AAU7J8Q2_LOCMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Locusta migratoria", "commonName": "Migratory locust", "taxonId": 7004, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89710.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Polyneoptera", "Orthoptera", "Caelifera", "Acrididea", "Acridomorpha", "Acridoidea", "Acrididae", "Oedipodinae", "Locusta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89710.1"}], "value": "Tudor domain-containing protein Tdr6"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 54, "modifier": "EXACT"}, "end": {"value": 114, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 325, "modifier": "EXACT"}, "end": {"value": 383, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 518, "modifier": "EXACT"}, "end": {"value": 576, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1033, "modifier": "EXACT"}, "end": {"value": 1091, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1246, "modifier": "EXACT"}, "end": {"value": 1304, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1448, "modifier": "EXACT"}, "end": {"value": 1505, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1636, "modifier": "EXACT"}, "end": {"value": 1694, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1828, "modifier": "EXACT"}, "end": {"value": 1888, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Region", "location": {"start": {"value": 669, "modifier": "EXACT"}, "end": {"value": 960, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 674, "modifier": "EXACT"}, "end": {"value": 685, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 705, "modifier": "EXACT"}, "end": {"value": 719, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 756, "modifier": "EXACT"}, "end": {"value": 765, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 794, "modifier": "EXACT"}, "end": {"value": 834, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 842, "modifier": "EXACT"}, "end": {"value": 879, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 886, "modifier": "EXACT"}, "end": {"value": 895, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 909, "modifier": "EXACT"}, "end": {"value": 923, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 924, "modifier": "EXACT"}, "end": {"value": 946, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 948, "modifier": "EXACT"}, "end": {"value": 957, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 2004, "modifier": "EXACT"}, "end": {"value": 2004, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89710.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3S1R4NEJO2BB6", "citationType": "submission", "authors": ["Deng S.", "Wang J.", "Ma E.", "Zhang J.", "Xing S."], "title": "Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89710.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR912208", "properties": [{"key": "ProteinId", "value": "XBN89710.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043186", "properties": [{"key": "GoTerm", "value": "C:P granule"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030719", "properties": [{"key": "GoTerm", "value": "P:P granule organization"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0034587", "properties": [{"key": "GoTerm", "value": "P:piRNA processing"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007283", "properties": [{"key": "GoTerm", "value": "P:spermatogenesis"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd20379", "properties": [{"key": "EntryName", "value": "Tudor_dTUD-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "2.30.30.140:FF:000018", "properties": [{"key": "EntryName", "value": "Serine/threonine-protein kinase 31"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "Gene3D", "id": "2.40.50.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "InterPro", "id": "IPR035437", "properties": [{"key": "EntryName", "value": "SNase_OB-fold_sf"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR050621", "properties": [{"key": "EntryName", "value": "Tudor_domain_containing"}]}, {"database": "PANTHER", "id": "PTHR22948:SF29", "properties": [{"key": "EntryName", "value": "FI02030P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22948", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "PROSITE", "id": "PS50304", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "8"}]}], "sequence": {"value": "MSSIEVYVTYLEKEGPFLKLWVQLNRSSAMFVEKLIRQYTDQFERGLFITHPSALIVGGICCAKYVDGMYYRARIISLANVSEGEIYVQFCDFGNKEVVPVSNIRNVQVRAGEPQPPLIAVPDQATEFYLAGVLPSQGGEWDDSTVDHIRQKLGYEEFQGVIVGETTRKKLLALYSGGIDISQVLIQEGLAVAITPSAQQILSHSLHAPQHVSQKVNPPTVPWQQFTPPPSVNRVVSVKSNPAYQVETMRAARTNVNMKKNPVQQGSGRVFGVPVLEVNSEHMVYVSFVDDGPLAFSVQLKAFEDQLSSMSIELNENPPQPMLKPLLPGSICLGRFSEDHLLCRAVVMSVMDDRCMVYYVDFGNSEVLPYSEIYEIPDKFMNLKSMALRYCLAGMRDTPLSDDLKDEFKKIVLDKLLKMKVVTPEGPPVKQYCELYLDGKNVKDLLLEKLKLQQLSKGYKKMPLPAVGLVEKVYVSYVESVSSFYVQLEANVSGLTNIMNYLASYCTRTQVQGFSPAQLQVGMPCCALFAADGRWYRAKITGVESNMVQVFYVDYGNSDTVPLSSLCKVEPTLLSQPPEQAIHCILNGYEHSGTDDDISATFELLVIEKLLSMKVLKHAAGGIVVDLYDATVQPMRNICDLLMVSQTKAAAAAVAAPPEVGNDWQENAALGTTYGDNSSGGNQREQYGGRGGNEDRNASFRKSQRHDNSVSHWQNKGEEMSSETSDTGASKGGSRFPGGGHRRDDRKSNAEAGRMGSEKEWDRNTKFGNKGGRYRDENTEPDGESQGDVFQNDRGGRQGNNRDRRRFPGGEKDDDTENRWASDRGRDRPYDSNRRGSGGRFRGSDRENDGESGRPSNRDSSRSYDENRGGSYGNRERGGGNRRGGRFGDRDKDNDWGGGGKGGRRFGTTAENSTSEDSTWNSNRKWEEKPDRNANKRDRWNSRDKGNSFGSYQNDADTTAVPAEEDLWGETEPSLKTIPPVDIQLNTVHTMHLIYVVNPSEFCLQMTDDSKLNALMEQIAAKYGDGGGTSLDNIKEGVTCAALYSLDGSWNRAVIETVHTDTVLCRFIDYGNSDEIPHSGLKILEKEFEQLPAQAIKCVLLCAKPSAGSWSEEEMLRFKEATDGKVISTKFVKRKGDVYEVILREAADSIKSINEDFGADPSEMENIAAAVCVSSGVCGNVDSGCATFGDKYQLQNTVGTKHDVVVSWFVNPENFYCQLISLQNELKNMMESIQKDYRKKKRQKVNVVVDTPVIARFKSDKVLYRAIVKELKNNAVVVQYIDFGNCDIADTSDIWPLEKKYLSYPVYALQCSLKGVKSPNSEWQISPSDVGKFFSEKLVCTFHEQVDHKYMITLENNGSSVAEALITEGIAVGDEKAPSATNISVSVEEDLDLALCQGQCLAAHVTYVCSLSKFFVHLNPARAIEIQACIENHMQQYSETAGKLPANSLKQGKMCLATPDGVSWYRAVIMETHPDNVTTNFIDFGDTAEVPVERMAPIPSDMMSCHRLAIECSVVGSSLDTAGELDEQFKLEVEEQDVILHVDSVCEDRLCVRLFDVEGQRLELLKELYNENLQEVEPVCPLPVLSSKMKVCVSHVEDNAPFFWIQNVQDIAGLSQLLESWFDFYETKSSGKDLIDIKPGKLCAAKSGNDDNWYRARINSVDNENASINFIDYGNTEIVPFTNIKSLDDGFYSPHAMALKVCLPVNVLDNEKTVSEFQNYTAEKEFVAQLSRNTSEEEYWFIDLISEGKRLIDELSNLGLITEAEDSPFAGNFMVKSMSEGVKTSVYVTYVESPSSFWVQLGSNLDEIEKLRNMLQKHANTADSMKTLPEVGMLCAAQYSEDASWYRAVVMDVEQSTVTVSFIDYGNTDKITLSSSGLKPLKPDLISLPPFGIKCSLDIRPMPNETEWSEAAIKKFNEIVDETGGVMVAEVLKSTDVNLVTLYTDESNVSSILIDLNLATSPSKKVEQLSVSQHESLQVGLLGNESDNLVFVSHCESPTDFWIQ", "length": 2004, "molWeight": 222822, "crc64": "ED9A85058B654529", "md5": "532F1A246B9A5ABC745ED4159DCEC3F9"}, "extraAttributes": {"countByFeatureType": {"Domain": 8, "Region": 1, "Compositional bias": 9, "Non-terminal residue": 1}, "uniParcId": "UPI0035D2F730"}, "cluster_size": 1, "family": "Acrididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7N2U1", "uniProtkbId": "A0AAU7N2U1_ACIRT", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Acipenser ruthenus", "commonName": "Sterlet sturgeon", "taxonId": 7906, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57380.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Chondrostei", "Acipenseriformes", "Acipenseridae", "Acipenser"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57380.1"}], "value": "IFNe2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000436"}], "value": "Belongs to the alpha/beta interferon family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 181, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043649913"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023118"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000436"}], "id": "KW-0051", "category": "Biological process", "name": "Antiviral defense"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022514"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000436"}], "id": "KW-0202", "category": "Molecular function", "name": "Cytokine"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7E12KI7O9QAUB", "citationType": "submission", "authors": ["Hu S.M."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57380.1"}], "value": "E2", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57380.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP893265", "properties": [{"key": "ProteinId", "value": "XBQ57380.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "RefSeq", "id": "XP_033912941.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_034057050.1"}]}, {"database": "GeneID", "id": "117434486", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005125", "properties": [{"key": "GoTerm", "value": "F:cytokine activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005126", "properties": [{"key": "GoTerm", "value": "F:cytokine receptor binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0051607", "properties": [{"key": "GoTerm", "value": "P:defense response to virus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006955", "properties": [{"key": "GoTerm", "value": "P:immune response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "Gene3D", "id": "1.20.1250.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009079", "properties": [{"key": "EntryName", "value": "4_helix_cytokine-like_core"}]}, {"database": "InterPro", "id": "IPR000471", "properties": [{"key": "EntryName", "value": "Interferon_alpha/beta/delta"}]}, {"database": "PANTHER", "id": "PTHR11691:SF73", "properties": [{"key": "EntryName", "value": "INTERFERON BETA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11691", "properties": [{"key": "EntryName", "value": "TYPE I INTERFERON"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00143", "properties": [{"key": "EntryName", "value": "Interferon"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00076", "properties": [{"key": "EntryName", "value": "IFabd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47266", "properties": [{"key": "EntryName", "value": "4-helical cytokines"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51257", "properties": [{"key": "EntryName", "value": "PROKAR_LIPOPROTEIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDLLRRSGLCFLFLCLSQNISLGCKWIQNGEYKHKSSFSLTLLKDMGEKDMSEDVNISIPEELYKLHSKSEIDNKISILHTALGQILKFYKKSEKRTTWDKDQLNQFMSLLHRQKLELNHCKTKGGCVGCKELKQYFKNLKRFLRSQKNSALAWEIIRKKVMDNLIRMELLASHIKNPPAI", "length": 181, "molWeight": 21147, "crc64": "05774B2A6C819CC0", "md5": "62DF7C33B44BBB443D539BEFFC7D0E5F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00145B9D06"}, "cluster_size": 5, "family": "Acipenseridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTW5", "uniProtkbId": "A0AAT9UTW5_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41678.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41678.1"}], "value": "Cytochrome P450 3638E1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 13, "modifier": "EXACT"}, "end": {"value": 34, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Coiled coil", "location": {"start": {"value": 259, "modifier": "EXACT"}, "end": {"value": 286, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Binding site", "location": {"start": {"value": 455, "modifier": "EXACT"}, "end": {"value": 455, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41678.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117238", "properties": [{"key": "ProteinId", "value": "WIM41678.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "METPLKVLLNRCWSSNFSTILIILFGVLWMYYLYKCRMRGLTKKLESFNSIPTVPLIGNLNILSGTKKERAIKWYKLVTEHETPLVFWLLHKPIFILGRSQDIQVVLNRTQERDLLGMFEMVFGDSITGLQGEKWRKHRRIVTSAFSPKMLQAYLKIFNKYSFLLTNDLKKFADNDNAIDTWNHVNHVNSLSITQNITGHKVEIGDRSIDEFTEAYSKSLGIETSRFTSPVLLPKLIYKLYLVISGKIEIFKTMRRFPRHIVKERLSEYEKKLQENEQREETDNSKTLIDSLLNAHIADAEFTEKHVSAEIANLIILGNDSTSTTINFVLLMMAMYPNIQERVYEEIKTVLGNSDREVETEDIRKFVYLERCIKETLRKFTVLPITFRRHNEDITLNDGRIIPANHTMLIAFYAAHHDRKVFPNPEKWDPEHFAPNNITTQREVFFPFGAGLRSCVGATYAMMSMKTQLVYLLRCYRFTTNMKMNDLKLTFLPGLRNTTGFWMKLWSRDT", "length": 510, "molWeight": 59617, "crc64": "8EAB96EDD73B1872", "md5": "8DBC98BA7FBED82EF0F3B92905A41839"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Coiled coil": 1, "Binding site": 1}, "uniParcId": "UPI0035D3CB3A"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXW9", "uniProtkbId": "TXUB_MEGOP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Megalopyge opercularis", "commonName": "Southern flannel moth", "synonyms": ["Phalaena opercularis"], "taxonId": 1113279, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Megalopygidae", "Megalopyge"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-megalopygitoxin(11)-Mo28"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-MPTX(11)-Mo28"}, {"evidences": [{"evidenceCode": "ECO:0000312", "source": "EMBL", "id": "WJJ70395.1"}], "value": "U-MPTX.11-28"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Probable toxin"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Expressed by the venom apparatus"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Larvae"}], "commentType": "DEVELOPMENTAL STAGE"}, {"commentType": "MASS SPECTROMETRY", "method": "MALDI", "molWeight": 1201.68, "molWeightError": 0.0, "note": "Monoisotopic mass.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the caterpillar 11 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Peptide", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "U-megalopygitoxin(11)-Mo28", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "featureId": "PRO_0000461527"}], "keywords": [{"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "37428925", "citationType": "journal article", "authors": ["Walker A.A.", "Robinson S.D.", "Merritt D.J.", "Cardoso F.C.", "Goudarzi M.H.", "Mercedes R.S.", "Eagles D.A.", "Cooper P.", "Zdenek C.N.", "Fry B.G.", "Hall D.W.", "Vetter I.", "King G.F."], "citationCrossReferences": [{"database": "PubMed", "id": "37428925"}, {"database": "DOI", "id": "10.1073/pnas.2305871120"}], "title": "Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).", "publicationDate": "2023", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "e2305871120", "lastPage": "e2305871120", "volume": "120"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "MASS SPECTROMETRY", "SYNTHESIS OF 30-40", "SUBCELLULAR LOCATION", "TISSUE SPECIFICITY", "DEVELOPMENTAL STAGE"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP514877", "properties": [{"key": "ProteinId", "value": "WJJ70395.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MRTTLLLLIIAITVMVFVSEAYAAPAPEPILKQGTIESLTR", "length": 41, "molWeight": 4472, "crc64": "6FE3226816FB5D34", "md5": "82F0A0C1E276A546474336AA49551C2E"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "DEVELOPMENTAL STAGE": 1, "MASS SPECTROMETRY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Peptide": 1}, "uniParcId": "UPI00388C33C6"}, "cluster_size": 1, "family": "Megalopygidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N818", "uniProtkbId": "A0AAN0N818_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34104.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34104.1"}], "value": "Epithelial sodium channel/degenerin-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007193"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "value": "Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 388, "modifier": "EXACT"}, "end": {"value": 409, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023053"}], "id": "KW-0915", "category": "Ligand", "name": "Sodium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022461"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0894", "category": "Molecular function", "name": "Sodium channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023201"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0739", "category": "Biological process", "name": "Sodium transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34104.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155030", "properties": [{"key": "ProteinId", "value": "WRW34104.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005272", "properties": [{"key": "GoTerm", "value": "F:sodium channel activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR001873", "properties": [{"key": "EntryName", "value": "ENaC"}]}, {"database": "Pfam", "id": "PF00858", "properties": [{"key": "EntryName", "value": "ASC"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTKSNFLKHFLIFFTCFYACFYQLRLLIDNYLSYEIETEVTTNYAEEKVIIPDISLCNFFIDLLDEDKLRKSSFKNYLFKNKLMKDNQLIKDLLRNEKIFQLFENFYTINQISYFFYEPKQIFRKIKSLVYNDTFIGLVEKECEFKFYSSLQDACYLIICPYQKKETKTYSNIYVKKNILSKSKNKNIFLQLNLNQDTLKKIFSPFAVYILSTNIGFPYRSSTKTSISLMSPDIPRKYIITYQRYRSRLLPAPYKTDCVDYQLQGHISRSQKIDKCIKIEKNAFEELRNRSYFGNLVYGNETNQYFDFYRQFFNSKEYKKLFPVLSFVYDKCANQSIKKDCYAQNFTPFLVQQLIIPNNSKTTVLKLLATTLPQIKNKTKPKLNPNNFFALACSIVSFWFGITIFRFIYFASDFYSSCKTKILKLKVKKQISKPTKTSLYSLHKTNLYIDKVKNFKRLKLSDKKKIELSNGTFEKK", "length": 476, "molWeight": 56703, "crc64": "09ED96933F9FA8D2", "md5": "064DE170A435AC0D57CCCFD3BF6B4CCF"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI00324FB712"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZE97", "uniProtkbId": "A0AB38ZE97_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71746.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71746.1"}], "value": "Heteropteran venom family 2 protein 3"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 220, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044290412"}, {"type": "Domain", "location": {"start": {"value": 67, "modifier": "EXACT"}, "end": {"value": 178, "modifier": "EXACT"}}, "description": "DUF4773", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF15998"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71746.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510821", "properties": [{"key": "ProteinId", "value": "WXH71746.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR031941", "properties": [{"key": "EntryName", "value": "DUF4773"}]}, {"database": "PANTHER", "id": "PTHR36299", "properties": [{"key": "EntryName", "value": "AGAP008005-PA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR36299:SF2", "properties": [{"key": "EntryName", "value": "DUF4773 DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF15998", "properties": [{"key": "EntryName", "value": "DUF4773"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYKVGLFIFTLISLCIFFIHGDTLTEEEMNQLINAPFITVNIEGDYERNLNQDRSLKDKLIQAKRMCQCHGITCGCCTKYTIMFVGIKACANITILPKEKAFKVFITVGGKSVYSSKIDAKNLEKVCSTVPKINSVELCLHNTIEEHAANGFTSCMSFDISWKGQLMANINFHCLKYEDNKLSFQENTITGKDAPATLKIRSPLELLAKLIEAGLKKLEE", "length": 220, "molWeight": 24718, "crc64": "06B9221A3CE44B0E", "md5": "616E44F3C4CB2C53A73E878B3F61438C"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388BDE87"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96C6Z0", "uniProtkbId": "A0AA96C6Z0_PSIGU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Psidium guajava", "commonName": "Guava", "synonyms": ["Psidium pyriferum"], "taxonId": 120290, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01956.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "malvids", "Myrtales", "Myrtaceae", "Myrtoideae", "Myrteae", "Pimenta group", "Psidium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01956.1"}], "value": "Terpene synthase"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001946"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 125, "modifier": "EXACT"}}, "description": "Terpene synthase N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01397"}]}, {"type": "Domain", "location": {"start": {"value": 173, "modifier": "EXACT"}, "end": {"value": 356, "modifier": "EXACT"}}, "description": "Terpene synthase metal-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03936"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022842"}], "id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FCTKIOK6O0LM0", "citationType": "submission", "authors": ["Canal D.", "dos Santos P.H.D.", "Carpinetti-Oliveira P.A.", "Silva M.A.", "Fernandes M.", "Brustolini O.J.B.", "Ferreira A.", "Ferreira M.F.S."], "title": "Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01956.1"}], "value": "Pg13454", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01956.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR232564", "properties": [{"key": "ProteinId", "value": "WNI01956.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0000287", "properties": [{"key": "GoTerm", "value": "F:magnesium ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0010333", "properties": [{"key": "GoTerm", "value": "F:terpene synthase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016114", "properties": [{"key": "GoTerm", "value": "P:terpenoid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.600.10", "properties": [{"key": "EntryName", "value": "Farnesyl Diphosphate Synthase"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "1.50.10.130", "properties": [{"key": "EntryName", "value": "Terpene synthase, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008949", "properties": [{"key": "EntryName", "value": "Isoprenoid_synthase_dom_sf"}]}, {"database": "InterPro", "id": "IPR001906", "properties": [{"key": "EntryName", "value": "Terpene_synth_N"}]}, {"database": "InterPro", "id": "IPR036965", "properties": [{"key": "EntryName", "value": "Terpene_synth_N_sf"}]}, {"database": "InterPro", "id": "IPR050148", "properties": [{"key": "EntryName", "value": "Terpene_synthase-like"}]}, {"database": "InterPro", "id": "IPR005630", "properties": [{"key": "EntryName", "value": "Terpene_synthase_metal-bd"}]}, {"database": "InterPro", "id": "IPR008930", "properties": [{"key": "EntryName", "value": "Terpenoid_cyclase/PrenylTrfase"}]}, {"database": "PANTHER", "id": "PTHR31225", "properties": [{"key": "EntryName", "value": "OS04G0344100 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31225:SF252", "properties": [{"key": "EntryName", "value": "TERPENE SYNTHASE 12-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01397", "properties": [{"key": "EntryName", "value": "Terpene_synth"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03936", "properties": [{"key": "EntryName", "value": "Terpene_synth_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48239", "properties": [{"key": "EntryName", "value": "Terpenoid cyclases/Protein prenyltransferases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48576", "properties": [{"key": "EntryName", "value": "Terpenoid synthases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MERLGLGDHFEEDILRALRRCLSPGAVHKSIDKSLHGAALSFRILRQHGFEVSQDVFKMFMDGSGSFMKTLGGDVQGMLSLYEASHLAFEGEDILQKARTFAIEHLQSLNPGVSKDLQDQVKHELELPLHRRMPLLEARRSIEAYSRRGNTNLLELAVTDFNTSQSTLQRDLQEMLRWDLDAVEGLPGYMKLCYLALYNSVNEMAYETLKRDRGKRHPVSSESGKSDVSVVSQWYDLCKAFLQEAKWINSKIIPGVEEYLNNGWASSSGQVMLTHAYFLSSPGMRKEELESLEQYDDLLRLPSLIFRLTNDIASSSAEIERGETTNSIRCYMQEKGVSETEARQCVTEQIDMAWKKMNKYMVHHSTFDRSFVRMAYNLARMAHCVYQDGDAIGAPDDQSWSRVHSLIIEPVSLAP", "length": 415, "molWeight": 47218, "crc64": "0573488D1A462F2E", "md5": "D5FFBF189A8B0D96FFEE17034431BC45"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1}, "countByFeatureType": {"Domain": 2}, "uniParcId": "UPI002B2D2E79"}, "cluster_size": 8, "family": "Myrtaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96SJC4", "uniProtkbId": "A0AA96SJC4_9STRA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Schizochytrium sp", "taxonId": 1907177, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94201.1"}], "lineage": ["Eukaryota", "Sar", "Stramenopiles", "Bigyra", "Labyrinthulomycetes", "Thraustochytrida", "Thraustochytriidae", "Schizochytrium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94201.1"}], "value": "Phosphatidate phosphatase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94201.1"}], "value": "pap"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004240"}], "value": "Endoplasmic reticulum", "id": "SL-0095"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 601, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041739307"}, {"type": "Domain", "location": {"start": {"value": 397, "modifier": "EXACT"}, "end": {"value": 581, "modifier": "EXACT"}}, "description": "MRH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51914"}]}, {"type": "Region", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 128, "modifier": "EXACT"}, "end": {"value": 182, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 46, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 68, "modifier": "EXACT"}, "end": {"value": 82, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 86, "modifier": "EXACT"}, "end": {"value": 114, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 141, "modifier": "EXACT"}, "end": {"value": 158, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-81MDF9VBSAK2G", "citationType": "submission", "authors": ["Pan X.", "Yang Q."], "title": "Metabolism balance regulation for squalene production by disturbing triglycerides (TAG) synthesis in Schizochytrium sp.", "publicationDate": "SEP-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94201.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP562239", "properties": [{"key": "ProteinId", "value": "WNT94201.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005788", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum lumen"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030968", "properties": [{"key": "GoTerm", "value": "P:endoplasmic reticulum unfolded protein response"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0030970", "properties": [{"key": "GoTerm", "value": "P:retrograde protein transport, ER to cytosol"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.70.130.10", "properties": [{"key": "EntryName", "value": "Mannose-6-phosphate receptor binding domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR009011", "properties": [{"key": "EntryName", "value": "Man6P_isomerase_rcpt-bd_dom_sf"}]}, {"database": "InterPro", "id": "IPR044865", "properties": [{"key": "EntryName", "value": "MRH_dom"}]}, {"database": "InterPro", "id": "IPR045149", "properties": [{"key": "EntryName", "value": "OS-9-like"}]}, {"database": "InterPro", "id": "IPR012913", "properties": [{"key": "EntryName", "value": "OS9-like_dom"}]}, {"database": "PANTHER", "id": "PTHR15414:SF0", "properties": [{"key": "EntryName", "value": "ENDOPLASMIC RETICULUM LECTIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR15414", "properties": [{"key": "EntryName", "value": "OS-9-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07915", "properties": [{"key": "EntryName", "value": "PRKCSH"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF50911", "properties": [{"key": "EntryName", "value": "Mannose 6-phosphate receptor domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51914", "properties": [{"key": "EntryName", "value": "MRH"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTNMTVLWRHFALVVAVAVVVAVLGSPQTVRAAASTSKASKPSTSAKDADSQFSTSGSGQQKSPANQDPRKQDVKVGMHLDLGDNAVEDDDYDDDYDDDYDDDYDDENDEDEDDNKAKEELVREQFLHHNSNKQKSSSTVQIQQQPKQQQQQQQQQQQQKKKQTFNKKDKPSASSMGNLHYSEDPTAARSRYLIHQLQEIQGIELVSQPEVSTSNTWKMTNIQGVPYECGFAASMGGESLYGFSKDDGAATAHAGGGGSKPILQSEDVLRSLEGLCIFVQKDYWSYDVCYKDGIYQYHGMSRAKASPVWSLGAYDPNETFVVTNTVTTASSVSNGQDSKHANSGKTSSLALVQRYRNGQVCDETGKPRESRIEYFCCPHLANNPGQDFQLESLNEHQICNYTITICSSALCNAGFVPRGSTDAWTTLRTISGLCFQDTLDWWTYSVCVERGVQQFHVQESVGTNGKRLVQKTSEYSLGKFQSDPAYNLPATLTAGSSMEKDPHSRTLLYIDRDRRNPAIVQVYTDGSPCAVSKTRSRMTIVRFVCDRASERASETNRILNVEEVTSCRYILTFHSHLLCQHSLFNTEEERGEKVTCNPAQT", "length": 601, "molWeight": 66928, "crc64": "06E947DDBF8AD4C8", "md5": "A0B6ECA4DD5F53FE1675FE2E87728C85"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 2, "Compositional bias": 5}, "uniParcId": "UPI001701C120"}, "cluster_size": 1, "family": "Thraustochytriidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJH7", "uniProtkbId": "A0AAU7LJH7_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28271.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28271.1"}], "value": "MADS76"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28271.1"}], "value": "MADS76"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 64, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 10, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28271.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28271.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400911", "properties": [{"key": "ProteinId", "value": "XBP28271.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "3.40.1810.10:FF:000006", "properties": [{"key": "EntryName", "value": "Agamous-like MADS-box protein AGL62"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR11945", "properties": [{"key": "EntryName", "value": "MADS BOX PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11945:SF782", "properties": [{"key": "EntryName", "value": "OS11G0229900 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MISNHKKTQGRQKIENKNSSQVTFSKRRTGLFKKACELSVLCGVEVATIAFSNNNKAFCFGHPSVEHVLHRYLHDSSSSSSLSCSSSTSRVSIASVLEKFNKEYMEAVKELKELKEKKK", "length": 119, "molWeight": 13371, "crc64": "CC6B53506933216A", "md5": "03CA836F14DBC7E2ECAA51F766641184"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D3B25A"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MKL5", "uniProtkbId": "A0AA96MKL5_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50098.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50098.1"}], "value": "Jacalin-related lectin-like protein"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 526, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041697422"}, {"type": "Domain", "location": {"start": {"value": 28, "modifier": "EXACT"}, "end": {"value": 177, "modifier": "EXACT"}}, "description": "Jacalin-type lectin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51752"}]}, {"type": "Domain", "location": {"start": {"value": 230, "modifier": "EXACT"}, "end": {"value": 378, "modifier": "EXACT"}}, "description": "Jacalin-type lectin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51752"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50098.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460175", "properties": [{"key": "ProteinId", "value": "WNS50098.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.100.10.30", "properties": [{"key": "EntryName", "value": "Jacalin-like lectin domain"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR001229", "properties": [{"key": "EntryName", "value": "Jacalin-like_lectin_dom"}]}, {"database": "InterPro", "id": "IPR036404", "properties": [{"key": "EntryName", "value": "Jacalin-like_lectin_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR47293", "properties": [{"key": "EntryName", "value": "JACALIN-RELATED LECTIN 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47293:SF43", "properties": [{"key": "EntryName", "value": "PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN DWY1, CHLOROPLASTIC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01419", "properties": [{"key": "EntryName", "value": "Jacalin"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SMART", "id": "SM00915", "properties": [{"key": "EntryName", "value": "Jacalin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF51101", "properties": [{"key": "EntryName", "value": "Mannose-binding lectins"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS51752", "properties": [{"key": "EntryName", "value": "JACALIN_LECTIN"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MAFTTAIGCITVVALLAISSVESYPFPVYYTVWYGSSKGYHFNDYTTHGLSSPSVVGVDKIYIRYKSTDVLAVQFTYRLSNGNCQMGSYHGGGTEYEGSDSFISLSKDEYVSRMSGRSNRNIYYLHFIIRNSITGRTRSYGYGYNQGGQHFTIAGPIYAIYGHAGSRVYYLGAYLPTPTTELYGYVDGSGFWDSVTSHFPAITRLQQVIGCITILALLAISSVESYPFPVYNTVWYGSSKGYHFNDYTRHGLSSTSVVGVDKIYIHYKSTDVLAVQFTYRLSNGGCQLGYYHGDGAEGGGSNSIISLSKDEYVARISGRYEITIRYLQFVIQNSITGRTRSYSYGYNRGQHFTIAGPIYAIYGHSGSRIDNLGVYLSTPATELHGYIRGTGFWDPVTSHFPAITRLQQVCIRSGADIDSVLFTYLTTTGSYTSGRYGGGGGGEGCFTLESYERISSVQIYKSETKGGVIIGLQFTISSSTSVRTYVQGPFGRLSGDGITLRRDTGVLGFYGYYTSTRLTGLGLIGH", "length": 526, "molWeight": 57826, "crc64": "1EBA90134B3AE4BA", "md5": "7A1C2F26992E9C127B6E3C2E92592EE0"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2}, "uniParcId": "UPI002B2A7289"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1G4", "uniProtkbId": "A0AAU7P1G4_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30739.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30739.1"}], "value": "Apolipoprotein E"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30739.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 78, "modifier": "EXACT"}, "end": {"value": 78, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30739.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30739.1"}], "value": "3", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30739.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892395", "properties": [{"key": "ProteinId", "value": "XBS30739.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "WRTCAAAWCSTAARCRPCSARAPRSCGCASPPTCASCVSGRAPRSCGCASPPTCASCVSGSSAMPMTCRSAWQCTRPG", "length": 78, "molWeight": 7908, "crc64": "90E6F84453CC79E0", "md5": "6337EB100CD4DEA94EB89EFD4FB0F319"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D35173"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAA9WUT9", "uniProtkbId": "A0AAA9WUT9_MOUSE", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159849.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159849.1"}], "value": "Neuroligin 4-like"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159849.1"}, {"evidenceCode": "ECO:0000313", "source": "MGI", "id": "MGI:3775191"}], "value": "Nlgn4l"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005964"}], "value": "Belongs to the type-B carboxylesterase/lipase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 269, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042037165"}, {"type": "Domain", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 139, "modifier": "EXACT"}}, "description": "Carboxylesterase type B", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00135"}]}, {"type": "Region", "location": {"start": {"value": 249, "modifier": "EXACT"}, "end": {"value": 269, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 259, "modifier": "EXACT"}, "end": {"value": 269, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAA9WUT9"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "19468303", "citationType": "journal article", "authoringGroup": ["Mouse Genome Sequencing Consortium"], "authors": ["Church D.M.", "Goodstadt L.", "Hillier L.W.", "Zody M.C.", "Goldstein S.", "She X.", "Bult C.J.", "Agarwala R.", "Cherry J.L.", "DiCuccio M.", "Hlavina W.", "Kapustin Y.", "Meric P.", "Maglott D.", "Birtle Z.", "Marques A.C.", "Graves T.", "Zhou S.", "Teague B.", "Potamousis K.", "Churas C.", "Place M.", "Herschleb J.", "Runnheim R.", "Forrest D.", "Amos-Landgraf J.", "Schwartz D.C.", "Cheng Z.", "Lindblad-Toh K.", "Eichler E.E.", "Ponting C.P."], "citationCrossReferences": [{"database": "PubMed", "id": "19468303"}, {"database": "DOI", "id": "10.1371/journal.pbio.1000112"}], "title": "Lineage-specific biology revealed by a finished genome assembly of the mouse.", "publicationDate": "2009", "journal": "PLoS Biol.", "firstPage": "e1000112", "lastPage": "e1000112", "volume": "7"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159849.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159849.1"}]}, {"referenceNumber": 2, "citation": {"id": "21750661", "citationType": "journal article", "authors": ["Church D.M.", "Schneider V.A.", "Graves T.", "Auger K.", "Cunningham F.", "Bouk N.", "Chen H.C.", "Agarwala R.", "McLaren W.M.", "Ritchie G.R.", "Albracht D.", "Kremitzki M.", "Rock S.", "Kotkiewicz H.", "Kremitzki C.", "Wollam A.", "Trani L.", "Fulton L.", "Fulton R.", "Matthews L.", "Whitehead S.", "Chow W.", "Torrance J.", "Dunn M.", "Harden G.", "Threadgold G.", "Wood J.", "Collins J.", "Heath P.", "Griffiths G.", "Pelan S.", "Grafham D.", "Eichler E.E.", "Weinstock G.", "Mardis E.R.", "Wilson R.K.", "Howe K.", "Flicek P.", "Hubbard T."], "citationCrossReferences": [{"database": "PubMed", "id": "21750661"}], "title": "Modernizing reference genome assemblies.", "publicationDate": "2011", "journal": "PLoS Biol.", "firstPage": "e1001091", "lastPage": "e1001091", "volume": "9"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159849.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159849.1"}]}, {"referenceNumber": 3, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159849.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159849.1"}]}], "uniProtKBCrossReferences": [{"database": "SMR", "id": "A0AAA9WUT9", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENSMUST00000249671.1", "properties": [{"key": "ProteinId", "value": "ENSMUSP00000159849.1"}, {"key": "GeneId", "value": "ENSMUSG00000121607.1"}]}, {"database": "AGR", "id": "MGI:3775191", "properties": [{"key": "Description", "value": "-"}]}, {"database": "MGI", "id": "MGI:3775191", "properties": [{"key": "GeneName", "value": "Nlgn4l"}]}, {"database": "GeneTree", "id": "ENSGT00940000156607", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000000589", "properties": [{"key": "Component", "value": "Chromosome X"}]}, {"database": "Gene3D", "id": "3.40.50.1820", "properties": [{"key": "EntryName", "value": "alpha/beta hydrolase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR029058", "properties": [{"key": "EntryName", "value": "AB_hydrolase_fold"}]}, {"database": "InterPro", "id": "IPR002018", "properties": [{"key": "EntryName", "value": "CarbesteraseB"}]}, {"database": "InterPro", "id": "IPR019819", "properties": [{"key": "EntryName", "value": "Carboxylesterase_B_CS"}]}, {"database": "InterPro", "id": "IPR051093", "properties": [{"key": "EntryName", "value": "Neuroligin/BSAL"}]}, {"database": "PANTHER", "id": "PTHR43903", "properties": [{"key": "EntryName", "value": "NEUROLIGIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00135", "properties": [{"key": "EntryName", "value": "COesterase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53474", "properties": [{"key": "EntryName", "value": "alpha/beta-Hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00941", "properties": [{"key": "EntryName", "value": "CARBOXYLESTERASE_B_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPAPAPALLCLALALASAQPSPPPPPPFPVVATNYGKLRGVRAALPGDVLGPVTQFLGVPYAAPPTGERRFQPPEPPSSWAGVRDATRFAPVCPQHLDERALLRDRLPAWFAANLDAIAAYVQDQSEDCLYLNLYVPGDPADPQLICIRAPSPPPATHVNPPHLHSPHPPRCHRLICIHLHAPPPGPRPRSDFFPVTFDLARAPRPPHAVPGLSRGRNLHFQIYFIFKIHFLLGFGDVRSLLVPDLRQGHGCLGNQRRRPGDAGGRGEI", "length": 269, "molWeight": 29225, "crc64": "860DF1736DA3DA2B", "md5": "3A0FF8F8B8E36E6348B2BC570C91E7B1"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B50440C"}, "cluster_size": 1, "family": "Muridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHG7", "uniProtkbId": "A0AAQ5BHG7_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519377.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519377.1"}], "value": "Tubulin beta 4A class IVa"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519377.1"}], "value": "TUBB4A"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 3, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "Tubulin/FtsZ GTPase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00091"}]}, {"type": "Region", "location": {"start": {"value": 109, "modifier": "EXACT"}, "end": {"value": 161, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHG7"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519377.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15057824", "citationType": "journal article", "authors": ["Grimwood J.", "Gordon L.A.", "Olsen A.", "Terry A.", "Schmutz J.", "Lamerdin J.", "Hellsten U.", "Goodstein D.", "Couronne O.", "Tran-Gyamfi M.", "Aerts A.", "Altherr M.", "Ashworth L.", "Bajorek E.", "Black S.", "Branscomb E.", "Caenepeel S.", "Carrano A.", "Caoile C.", "Chan Y.M.", "Christensen M.", "Cleland C.A.", "Copeland A.", "Dalin E.", "Dehal P.", "Denys M.", "Detter J.C.", "Escobar J.", "Flowers D.", "Fotopulos D.", "Garcia C.", "Georgescu A.M.", "Glavina T.", "Gomez M.", "Gonzales E.", "Groza M.", "Hammon N.", "Hawkins T.", "Haydu L.", "Ho I.", "Huang W.", "Israni S.", "Jett J.", "Kadner K.", "Kimball H.", "Kobayashi A.", "Larionov V.", "Leem S.H.", "Lopez F.", "Lou Y.", "Lowry S.", "Malfatti S.", "Martinez D.", "McCready P.", "Medina C.", "Morgan J.", "Nelson K.", "Nolan M.", "Ovcharenko I.", "Pitluck S.", "Pollard M.", "Popkie A.P.", "Predki P.", "Quan G.", "Ramirez L.", "Rash S.", "Retterer J.", "Rodriguez A.", "Rogers S.", "Salamov A.", "Salazar A.", "She X.", "Smith D.", "Slezak T.", "Solovyev V.", "Thayer N.", "Tice H.", "Tsai M.", "Ustaszewska A.", "Vo N.", "Wagner M.", "Wheeler J.", "Wu K.", "Xie G.", "Yang J.", "Dubchak I.", "Furey T.S.", "DeJong P.", "Dickson M.", "Gordon D.", "Eichler E.E.", "Pennacchio L.A.", "Richardson P.", "Stubbs L.", "Rokhsar D.S.", "Myers R.M.", "Rubin E.M.", "Lucas S.M."], "citationCrossReferences": [{"database": "PubMed", "id": "15057824"}, {"database": "DOI", "id": "10.1038/nature02399"}], "title": "The DNA sequence and biology of human chromosome 19.", "publicationDate": "2004", "journal": "Nature", "firstPage": "529", "lastPage": "535", "volume": "428"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519377.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519377.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519377.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC010503", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHG7", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714086.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519377.1"}, {"key": "GeneId", "value": "ENSG00000104833.12"}]}, {"database": "HGNC", "id": "HGNC:20774", "properties": [{"key": "GeneName", "value": "TUBB4A"}]}, {"database": "OpenTargets", "id": "ENSG00000104833", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000161972", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 19"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.40.50.1440:FF:000034", "properties": [{"key": "EntryName", "value": "Tubulin beta chain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.1440", "properties": [{"key": "EntryName", "value": "Tubulin/FtsZ, GTPase domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR013838", "properties": [{"key": "EntryName", "value": "Beta-tubulin_BS"}]}, {"database": "InterPro", "id": "IPR036525", "properties": [{"key": "EntryName", "value": "Tubulin/FtsZ_GTPase_sf"}]}, {"database": "InterPro", "id": "IPR003008", "properties": [{"key": "EntryName", "value": "Tubulin_FtsZ_GTPase"}]}, {"database": "PANTHER", "id": "PTHR36527", "properties": [{"key": "EntryName", "value": "OS01G0282866 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR36527:SF3", "properties": [{"key": "EntryName", "value": "OS01G0282866 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00091", "properties": [{"key": "EntryName", "value": "Tubulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52490", "properties": [{"key": "EntryName", "value": "Tubulin nucleotide-binding domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00228", "properties": [{"key": "EntryName", "value": "TUBULIN_B_AUTOREG"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGRAKEAPSRRKLCPQSGAGGPGTRHHGLCPFWPLRSDLSAGQLRVWPIRSRQQLGKGALHGGRRAGGRCPGRSPEGGRELRLPSGLPADPLAGGWHGVRNGHAAHQ", "length": 161, "molWeight": 17402, "crc64": "5059707CF57EE974", "md5": "22FE4933C9111BF1C520A3ADE5935BDF"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1}, "uniParcId": "UPI0032C7AAEF"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PB50", "uniProtkbId": "A0AAU6PB50_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Osedax japonicus", "taxonId": 385425, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42271.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Sedentaria", "Canalipalpata", "Sabellida", "Siboglinidae", "Osedax"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42271.1"}], "value": "Chitin synthase 2"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42271.1"}], "value": "CS2"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 15, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 65, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 77, "modifier": "EXACT"}, "end": {"value": 93, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 105, "modifier": "EXACT"}, "end": {"value": 124, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 378, "modifier": "EXACT"}, "end": {"value": 397, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 423, "modifier": "EXACT"}, "end": {"value": 444, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 201, "modifier": "EXACT"}, "end": {"value": 232, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 250, "modifier": "EXACT"}, "end": {"value": 272, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 553, "modifier": "EXACT"}, "end": {"value": 587, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 205, "modifier": "EXACT"}, "end": {"value": 214, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 253, "modifier": "EXACT"}, "end": {"value": 271, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 556, "modifier": "EXACT"}, "end": {"value": 569, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42271.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38831357", "citationType": "journal article", "authors": ["Tilic E.", "Miyamoto N.", "Herranz M.", "Worsaae K."], "citationCrossReferences": [{"database": "PubMed", "id": "38831357"}], "title": "Hooked on zombie worms? Genetic blueprints of bristle formation in Osedax japonicus (Annelida).", "publicationDate": "2024", "journal": "Evodevo", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42271.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-2J69OR40U6SUT", "citationType": "submission", "authors": ["Tilic E."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42271.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP475510", "properties": [{"key": "ProteinId", "value": "WXA42271.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0071944", "properties": [{"key": "GoTerm", "value": "C:cell periphery"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004100", "properties": [{"key": "GoTerm", "value": "F:chitin synthase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006031", "properties": [{"key": "GoTerm", "value": "P:chitin biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR004835", "properties": [{"key": "EntryName", "value": "Chitin_synth"}]}, {"database": "PANTHER", "id": "PTHR22914", "properties": [{"key": "EntryName", "value": "CHITIN SYNTHASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22914:SF42", "properties": [{"key": "EntryName", "value": "CHITIN SYNTHASE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLAGAVHVVLAGSYYYLWLSLSYGLAVFYIMVCFKCRPSVQLLVAGYMSVGYAIVMLVVSVGIIVQTSQDTWTSPNAMFLLVIVGIFSSAAFLHPEEFMCLLPGILYFLCIPSGFVLLFIYSIVNLHIVTWGTRETNPTGSQPEKQENKMLIQEIFDEIKYILTMVFCCLKKRCVHFIEERTVIESPTTKRKKMVKEILEELGQDGQTASTRNRSSSSQDEKSSEITANTTISTRSALSRQLRDDIEQVIVQRDAENAPSEKEETLSERRKNISTRLQQIHNGAMRDSKRSKVTHESDIIEVDNIQCEAENQDDLQISWLWQTWLNGGSIVPLDAVETLFWKRLIEKYLKPSQDDEEGRRQRKIIKAELITLRNNTSFLFFMLNFIWLFIILLLQIVQEQLRDKLYIKVAKAGSSEQMQFEPLSVAFLVFFALIIVVQFVTMIFHRYGTFLHIISSTSLSGCFSCRQKYDEVGIRDIVETVKYMQRIKDCADSDEINISANSSDTDGGYACLGSGGPGNQLEPDIVSQTRVKTQGKTLRAAFARRYNALTADRGANEGGADYGRPGAGQRGRRSRPQINGAFDNAQV", "length": 587, "molWeight": 66361, "crc64": "28ED3E44CE1BC97C", "md5": "D4792322A3ADC443E6EAAE62A2E68EDE"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 6, "Region": 3, "Compositional bias": 3, "Non-terminal residue": 1}, "uniParcId": "UPI0035D2B2A2"}, "cluster_size": 1, "family": "Siboglinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96ZP25", "uniProtkbId": "A0AA96ZP25_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29089.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29089.1"}], "value": "VWACP-6"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 221, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041741574"}, {"type": "Domain", "location": {"start": {"value": 32, "modifier": "EXACT"}, "end": {"value": 210, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29089.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651426", "properties": [{"key": "ProteinId", "value": "WNX29089.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF20", "properties": [{"key": "EntryName", "value": "PH DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00453", "properties": [{"key": "EntryName", "value": "VWFADOMAIN"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLQVSFLILLVILCGYAPAPAFSYLHCSRPADVIFLLDSSKSIGEDEFKKQLSFVQQVVEYFDVSRGNIRVGLILYTDVAVAEFNLARYSSKEFVKDAVGRIFYVGGDGRNSHLAIKKADEHMFQYHWVHNYGLHMIVYITTGKATDHEEAVKEAQEAKKGSMIFTLGVGSQVDMKKLGQLATQDSNQFVFNASSFDDLLLQKYTVARQICSGGEDRQRKR", "length": 221, "molWeight": 24892, "crc64": "7C2E41AAA04A930F", "md5": "B9850272D007EFFD788952332772ADEC"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B28C5E5"}, "cluster_size": 1, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTU7", "uniProtkbId": "A0AAT9UTU7_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41680.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41680.1"}], "value": "Cytochrome P450 3638F1"}}], "flag": "Fragment"}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41680.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 371, "modifier": "EXACT"}, "end": {"value": 371, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41680.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41680.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117240", "properties": [{"key": "ProteinId", "value": "WIM41680.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VEMLKSFDQIPTIPVIGSSYLFIGGMRERVEKMINAMNNYEAPVVLWLMNIPVVCIGEHEDTQAIFNKCQHIEYLNVFDKIFGDALPRLQGEKWRKSRQTASYAFSPTTMHHYFTIINEYSAILTKDLEPFCDTNQVFDIKSYISKANLNSITMNMAGYKISSLENEDTELNNAFSEALRMESTRYTVPFLLPKIMYETYLFLFGKNRVYEIIQKFPKKIIQERLPMYRTTGHQRSEIGQNISKYVKKDKKGPKLLIDLLFKRHNTDADFTKEHILDEVKGMILAGYTTTHEAVSFVLLMLAMHHEAQEKVYEEIETICGDDEEFQMEDLKELVYMEQCVNETLRKFTIVPVDFRTHHEDIMLKNGQVIPA", "length": 371, "molWeight": 43240, "crc64": "81A52261C29F0DF9", "md5": "69AC5F50A7FACC66B53B1DE04A061DF0"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D27D98"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VHS7", "uniProtkbId": "A0AAU7VHS7_PONPI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pongamia pinnata", "commonName": "Pongam oil-tree", "synonyms": ["Millettia pinnata"], "taxonId": 56065, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75475.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Fabales", "Fabaceae", "Papilionoideae", "50 kb inversion clade", "NPAAA clade", "indigoferoid/millettioid clade", "Millettieae", "Pongamia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75475.1"}], "value": "Trehalose phosphate synthase"}}], "flag": "Fragment"}, "features": [{"type": "Region", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 61, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75475.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75475.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-15U5C92M41UO1", "citationType": "submission", "authors": ["Mehra A.", "Mazumdar-Leighton S."], "title": "Transcripts identified in leaf tissues of Pongamia pinnata at the University of Delhi, India.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75475.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP908487", "properties": [{"key": "ProteinId", "value": "XBW75475.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MTSPIDYVLCIGHFLGKDEDLYSFFEPYLPSIGVGPPGSQVTTEGVKFPVERKIPAMKSGPKSSPNKAQRPVSNSEKKT", "length": 79, "molWeight": 8613, "crc64": "D83B4DE2EEE10844", "md5": "F816CE48CC447487FDBEC98DE6A7B2D5"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D3003E"}, "cluster_size": 1, "family": "Fabaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39J3M6", "uniProtkbId": "A0AB39J3M6_STIJA", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Stichopus japonicus", "commonName": "Sea cucumber", "taxonId": 307972, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88986.1"}], "lineage": ["Eukaryota", "Metazoa", "Echinodermata", "Eleutherozoa", "Echinozoa", "Holothuroidea", "Aspidochirotacea", "Aspidochirotida", "Stichopodidae", "Apostichopus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88986.1"}], "value": "Guanylate binding protein 1"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01052"}], "value": "Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 154, "modifier": "EXACT"}}, "description": "GB1/RHD3-type G", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51715"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023134"}], "id": "KW-0342", "category": "Ligand", "name": "GTP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9KB24OKSBOGJC", "citationType": "submission", "authors": ["Yang L.", "Li C."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88986.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ120687", "properties": [{"key": "ProteinId", "value": "XDN88986.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003924", "properties": [{"key": "GoTerm", "value": "F:GTPase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.20.1000.10", "properties": [{"key": "EntryName", "value": "Guanylate-binding protein, C-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR030386", "properties": [{"key": "EntryName", "value": "G_GB1_RHD3_dom"}]}, {"database": "InterPro", "id": "IPR003191", "properties": [{"key": "EntryName", "value": "Guanylate-bd/ATL_C"}]}, {"database": "InterPro", "id": "IPR036543", "properties": [{"key": "EntryName", "value": "Guanylate-bd_C_sf"}]}, {"database": "InterPro", "id": "IPR015894", "properties": [{"key": "EntryName", "value": "Guanylate-bd_N"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "PANTHER", "id": "PTHR10751", "properties": [{"key": "EntryName", "value": "GUANYLATE BINDING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02263", "properties": [{"key": "EntryName", "value": "GBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02841", "properties": [{"key": "EntryName", "value": "GBP_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48340", "properties": [{"key": "EntryName", "value": "Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51715", "properties": [{"key": "EntryName", "value": "G_GB1_RHD3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MESRTSVPLCLPSNFRWNQRNAAIEVQENEPRGNITVCPEGLKLLQSIQEDNVVVVCITGPARTGKSYFLSQIEEGASFKVSHTTTAETTGIWISVAPTLLTVNGKVARLVLLDVEGLGSTSTVDQGGSTEKWDMKVFTLCALFSSYLIYNSRNVPTVDDLDKLGFIAQFRSFIYGHSAPTTVEGSPEDIQVDIAPYFMWLIRDTLLQPQVDGKDCSWEKYITSSVLSVNDDGVKNRRNAIKKAICTTFRHFDAYGLPPPSVKLEVVRNLSLPEHRAEINPEFLKGIQDVKEKVLSLSQVKKILGCYPTGDQLATYVSECVKSVNKGLDKLSVPNTLDSLIELRLNDSFHQATQKYDKCIQKLKLPVLTRVAKRFHHDASKEAQEELFQLLSPTFDDDTRAIWSEKLTTALEKKYDNLKEKNLSESRKQCENVAAELTKTYLTAKTDTLKKNCFKDVVAKEAILREYSSKAKGPLVNEVKAKLKERIQHRINDVSSAIIQASLKTVDEMYARGENKVKREMPFEEHILEAKYKQIVTSCSNLFIRKCEGCYQFHEKLSCLKKDLRDRFDTLQNHNDTCSQDECEKTMKALKMKDFDAILNMAKDASYSHLIDAKEKIITKYDQAAVGPAKDKVKRNYMEKIDEQLSRAQGIISLAAFEEAEKELKEYLDLVEKRDPLETEKETSQYETKCTNIRKTYEGRCCGIDTTVASVYKTKLSKLEGRNRTKFVTLQKRRSEDFCRKLMEKLIRENLTPLLDDVQFLADFTKAKEHILKLYNEQAKGPSSEDIQREYLVKIDRDIDIGQQQRVLKGCKLAADAALELAKLSSQFGGNPAKIAAGSAAFIQLAKDAMNK", "length": 852, "molWeight": 96401, "crc64": "63B7329FB105901F", "md5": "E423E98319BBEE64AC770FA1B867E431"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI00388C1312"}, "cluster_size": 2, "family": "Stichopodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8KYC4", "uniProtkbId": "A0AAU8KYC4_HALDU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28590.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28590.1"}], "value": "MRTF"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Repeat", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "RPEL", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00401"}]}, {"type": "Repeat", "location": {"start": {"value": 132, "modifier": "EXACT"}, "end": {"value": 157, "modifier": "EXACT"}}, "description": "RPEL", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00401"}]}, {"type": "Domain", "location": {"start": {"value": 501, "modifier": "EXACT"}, "end": {"value": 535, "modifier": "EXACT"}}, "description": "SAP", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50800"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 171, "modifier": "EXACT"}, "end": {"value": 197, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 217, "modifier": "EXACT"}, "end": {"value": 236, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 241, "modifier": "EXACT"}, "end": {"value": 387, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 435, "modifier": "EXACT"}, "end": {"value": 464, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 631, "modifier": "EXACT"}, "end": {"value": 716, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 172, "modifier": "EXACT"}, "end": {"value": 182, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 255, "modifier": "EXACT"}, "end": {"value": 265, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 274, "modifier": "EXACT"}, "end": {"value": 283, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 284, "modifier": "EXACT"}, "end": {"value": 293, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 311, "modifier": "EXACT"}, "end": {"value": 330, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 346, "modifier": "EXACT"}, "end": {"value": 361, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 362, "modifier": "EXACT"}, "end": {"value": 379, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 444, "modifier": "EXACT"}, "end": {"value": 460, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 690, "modifier": "EXACT"}, "end": {"value": 699, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EGAS7BV8JDS8L", "citationType": "submission", "authors": ["Mikhailov K.", "Kravchuk O.", "Lyupina Y.", "Adameyko K."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28590.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP971924", "properties": [{"key": "ProteinId", "value": "XCN28590.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003713", "properties": [{"key": "GoTerm", "value": "F:transcription coactivator activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "6.10.140.2040", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "6.10.150.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.720.30", "properties": [{"key": "EntryName", "value": "SAP domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR043451", "properties": [{"key": "EntryName", "value": "Myocardin-like"}]}, {"database": "InterPro", "id": "IPR004018", "properties": [{"key": "EntryName", "value": "RPEL_repeat"}]}, {"database": "InterPro", "id": "IPR003034", "properties": [{"key": "EntryName", "value": "SAP_dom"}]}, {"database": "InterPro", "id": "IPR036361", "properties": [{"key": "EntryName", "value": "SAP_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR22793:SF12", "properties": [{"key": "EntryName", "value": "MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22793", "properties": [{"key": "EntryName", "value": "MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02037", "properties": [{"key": "EntryName", "value": "SAP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00707", "properties": [{"key": "EntryName", "value": "RPEL"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SMART", "id": "SM00513", "properties": [{"key": "EntryName", "value": "SAP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF68906", "properties": [{"key": "EntryName", "value": "SAP domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51073", "properties": [{"key": "EntryName", "value": "RPEL"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50800", "properties": [{"key": "EntryName", "value": "SAP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MASDVPRARALDREGSGRGGFTPELPPVLEGVQESPVPRHEAQQAVEWKLNQRPLKQELIARNILSSIPASPALQSQAVRLQWEKKSNQLEQRIRRRPQLNDVVNLNILKDPKLSPGVQAAQDQIRRKNLAESLNNRIALRPGPLELIKDGILNPGDASILRALKSIPLAKKSSDDSEKGDPPEACPSPSPSSIDMSAELSSSNFVSDVIRRKSIQESAKTGALPSLGPYSSKRHSIGAAPSLDSVFQSPPPATGQLSLSMSMDETSCMEWESGEGRQGRKASESSLSSLPSPIDFSCLQADSPLGMRSPESVQRSASSPSATANGQPFSASLLYKKRGGVMSPRPQRKKSSSKSSKVRKYNFHEYKPPNHQGKIEKKPSTTTKPSGPYDYIVQQQQILLQIQLLQQQYPEQLSQISNSGDKDQQMTAIMKALGELSQQGGAGKKGDKSGRGTPKLDAHKSGLGGGAGGCSVVNGATTAASSAQMSPDTLVACDNGQKVKVEELKVNHLRSACKDRGLGVTGKKCELLERLLEHNRRKLPASVYAEVALDRRQSLSLGSGGVTPAAGGNGPAKPLRCDPAPSKQKLQAEQLQEKIKEICEQSKRVHLSGKSGTLYPAPVVEAMYNFDLQTPPSSTASVPQTPPPSWEAQALVASQPPKFSPLRNHSLPLSSELGKGPASDDLLQLISSRPSPPFQPSPAPAAKLSAASPPPQQVMSPTQDLLEQLKLSGAVSWSPDTATPPTTTNPLLTMSNGTYAGKFSDSSIGMGVSPGGLHQCSGLVRDTPLLASTASHPFQDQLLSTPAKSEGPYGCSSKETLEPLITSSTSQTLFDFLDLEQPTGLHSLYGSSPVGQQSGKTPHPLHAHLPVPSPMLGITVPTVKSGSDLYLPGHEYSAVQPSLPPLSRSPGSDQLEWLDLESSFGSQAPNSAGQGGGGGCLTDLQFGELGTFLDGVPSMGGNPREVPQYQPPDFHNDLGFGSLGNSNFVDNSDIFQPATSEQSFVEIGMSH", "length": 1007, "molWeight": 107066, "crc64": "B6EFD470E9908A53", "md5": "23E692E5A63C77786BD1953C3FFCDAA5"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Repeat": 2, "Domain": 1, "Region": 6, "Compositional bias": 10}, "uniParcId": "UPI0035D3BF83"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N5Z2", "uniProtkbId": "A0AAN0N5Z2_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06419.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06419.1"}], "value": "Nicotinic acetylcholine receptor"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06419.1"}], "value": "nAChR"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003328"}], "value": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009237"}], "value": "Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 234, "modifier": "EXACT"}, "end": {"value": 259, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 265, "modifier": "EXACT"}, "end": {"value": 287, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 299, "modifier": "EXACT"}, "end": {"value": 322, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 788, "modifier": "EXACT"}, "end": {"value": 807, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Domain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 233, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel ligand-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02931"}]}, {"type": "Domain", "location": {"start": {"value": 240, "modifier": "EXACT"}, "end": {"value": 414, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel transmembrane", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02932"}]}, {"type": "Domain", "location": {"start": {"value": 726, "modifier": "EXACT"}, "end": {"value": 804, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel transmembrane", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02932"}]}, {"type": "Region", "location": {"start": {"value": 620, "modifier": "EXACT"}, "end": {"value": 641, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06419.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06419.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP191258", "properties": [{"key": "ProteinId", "value": "WTM06419.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0022848", "properties": [{"key": "GoTerm", "value": "F:acetylcholine-gated monoatomic cation-selective channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004888", "properties": [{"key": "GoTerm", "value": "F:transmembrane signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007271", "properties": [{"key": "GoTerm", "value": "P:synaptic transmission, cholinergic"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "CDD", "id": "cd19031", "properties": [{"key": "EntryName", "value": "LGIC_ECD_nAChR_proto_alpha-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd19064", "properties": [{"key": "EntryName", "value": "LGIC_TM_nAChR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.70.170.10:FF:000013", "properties": [{"key": "EntryName", "value": "Acetylcholine receptor subunit alpha"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.20.58.390:FF:000012", "properties": [{"key": "EntryName", "value": "Acetylcholine receptor subunit alpha-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.70.170.10", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel ligand-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.390", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR006202", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd"}]}, {"database": "InterPro", "id": "IPR036734", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd_sf"}]}, {"database": "InterPro", "id": "IPR006201", "properties": [{"key": "EntryName", "value": "Neur_channel"}]}, {"database": "InterPro", "id": "IPR036719", "properties": [{"key": "EntryName", "value": "Neuro-gated_channel_TM_sf"}]}, {"database": "InterPro", "id": "IPR038050", "properties": [{"key": "EntryName", "value": "Neuro_actylchol_rec"}]}, {"database": "InterPro", "id": "IPR006029", "properties": [{"key": "EntryName", "value": "Neurotrans-gated_channel_TM"}]}, {"database": "InterPro", "id": "IPR018000", "properties": [{"key": "EntryName", "value": "Neurotransmitter_ion_chnl_CS"}]}, {"database": "InterPro", "id": "IPR002394", "properties": [{"key": "EntryName", "value": "Nicotinic_acetylcholine_rcpt"}]}, {"database": "NCBIfam", "id": "TIGR00860", "properties": [{"key": "EntryName", "value": "LIC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR18945", "properties": [{"key": "EntryName", "value": "NEUROTRANSMITTER GATED ION CHANNEL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02931", "properties": [{"key": "EntryName", "value": "Neur_chan_LBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02932", "properties": [{"key": "EntryName", "value": "Neur_chan_memb"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00254", "properties": [{"key": "EntryName", "value": "NICOTINICR"}]}, {"database": "PRINTS", "id": "PR00252", "properties": [{"key": "EntryName", "value": "NRIONCHANNEL"}]}, {"database": "SUPFAM", "id": "SSF90112", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane pore"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63712", "properties": [{"key": "EntryName", "value": "Nicotinic receptor ligand binding domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00236", "properties": [{"key": "EntryName", "value": "NEUROTR_ION_CHANNEL"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKQQNLKKSLVILSNQDAKRLYDDLMSNYSNLVRPVKNLSEPVTVRIKLKLSQLIEVNLKDQIMTTSMWVEQYWHDGLLTWNPDDYGGIKMMHVPSDQIWRPDIVLYNNAAGDFEVTLSTKAQLSHKGDIKWNPPAMFKSYCEIDVEYFPFDEQTCLMKFGSWTNDGWILDLRHVDEIPGQSDVEFGIDLSDFYLSVEWDLIEVPARRHTKYYLCCESPYLDLTFNISMRRKTLFYTVNLIIPCMGISFLTVLVFYLPSDSGEKISLSVSILVALTVFFLLLAETIPPTSLVVPFLGKYLLFTMLLVGLSICVTVLVLNVHFRSGSTHHMSNRMRKLFLEILPKYLFMERPNYQYSNNSLYFNGYTNNLKNYFSLELEKDFNKIFQRRKRKRRTFKNLNEPNLKKMNNVNRNIKDKFNKDENSIKQNENTLINVDFECSTCDFKNLKTTTKPYNFDNDQSLTNSIKSFQNQIKSPFKNKCLKCLKLNRDQIVPSNYNFVNNFNNQSDSIDNFNEINLKNEYELRPMHSSKNNLNCQNYKTINDKNFNHFNHFEMQNKNEYKSEIENEYKNENEYFLEYNSDIENKYESDYKNIENQSILENDSNNEINDFNNEFENNFHNNENSDNESNLNSDMNDSNNNNFSEINSSNIIKSNEFLNKSFNQQVKRQFSDSVIKSDDYNLKMKSAMSIDQFINYKSCSFSEKCNTCNKVIDNKFSSIDNLPFNKQRNSKIEKDQNIFIKTFYTLEKNPYILRSMKNAYFLAEHNRKCILEEEIKQDWKYVAMVLDRLFLWIFLLAVLFGTFSIILLDKRHPADQKISQLAFSVLNKTRFTQSFWHE", "length": 837, "molWeight": 98879, "crc64": "8745B31EF40DC6DE", "md5": "3D10197C58D458E43B48F62E615BD978"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 4, "Domain": 3, "Region": 1}, "uniParcId": "UPI00324DEB6D"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MKG8", "uniProtkbId": "A0AA96MKG8_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50077.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50077.1"}], "value": "Uncharacterized protein 15"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 210, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041737706"}, {"type": "Region", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 119, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 174, "modifier": "EXACT"}, "end": {"value": 210, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 186, "modifier": "EXACT"}, "end": {"value": 201, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50077.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460154", "properties": [{"key": "ProteinId", "value": "WNS50077.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSCVGKILLSVAILAVCLQAAPIAKPPASDKFMPASCPAAKTGKYLVVLEYPVEQPGSSEQKAAPSFVFKKYMDSHLTKEDDQVKEEQPTKADILNQVSLSPDGPTSAVPTDTDDNEDKQAVVKSYSMLIDELMYHVDMNDPALLDVLGMSGVAFVEEEMTVIGANCGGGFGGDFGGDGFGGDKGEGEEEEGESGSEDDESQQPMMMMLG", "length": 210, "molWeight": 22242, "crc64": "C235ED29AEEFAFF8", "md5": "25DA830983D616D2F58EEC77AA03F4B1"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 2, "Compositional bias": 2}, "uniParcId": "UPI002B2F8AAE"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QKA6", "uniProtkbId": "A0AAU0QKA6_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56455.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56455.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 101, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56455.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56455.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56455.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970348", "properties": [{"key": "ProteinId", "value": "WPO56455.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVHDINNPFAEPEERFESPFFEIVFAFMTGSVVIWIVNYSSYDALFGIVTNHARIKMIVFCMKLEDAFDQKDDQLMQKGVKEFINEQNRMYRFVDVIQDSYNVWLGIILTITMIQLSFLMFHISAGYGFDLRYIFFSLICVAHIFLPCNYASNLKIMSTETATMIYCSRWETVLSKKVAKVIPFIIARAQIPIQLTFYIFEFDMKLFVNILKSSYSIFMLMRT", "length": 223, "molWeight": 26204, "crc64": "EFE8EFE509E7249D", "md5": "1746533D21BE08E7D67AAE0EADF5CCE6"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 3}, "uniParcId": "UPI003092FA8D"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BGU8", "uniProtkbId": "A0AAQ5BGU8_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519087.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519087.1"}], "value": "Proprotein convertase subtilisin/kexin type 9"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519087.1"}], "value": "PCSK9"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 30, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 31, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042953916"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BGU8"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BGU8"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519087.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519087.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519087.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519087.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC091609", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AL589790", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BGU8", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000713785.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519087.1"}, {"key": "GeneId", "value": "ENSG00000169174.13"}]}, {"database": "HGNC", "id": "HGNC:20001", "properties": [{"key": "GeneName", "value": "PCSK9"}]}, {"database": "OpenTargets", "id": "ENSG00000169174", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00490000043472", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}], "sequence": {"value": "MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKTEAAWWRCIS", "length": 79, "molWeight": 8779, "crc64": "2D58166FFB751B9D", "md5": "2FE18C2E541D8B0C6494C8EA92F4324E"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0032CF2D03"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEF8", "uniProtkbId": "A0AB38ZEF8_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00904.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00904.1"}], "value": "Venom peptide Es3a"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044322436"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00904.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-RUDT4T1F4QC9", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00904.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP516299", "properties": [{"key": "ProteinId", "value": "WXI00904.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MDFLKMLFFIALCIMMALGASGQNCIPRGNPCRGNARCCGMNACAGGRCVPTPGK", "length": 55, "molWeight": 5769, "crc64": "D38ED7BA52C79FDC", "md5": "50B88F3BBF53282E64A838560DBE5399"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C083A"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0YZ94", "uniProtkbId": "A0AAF0YZ94_HIRNI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hirudo nipponia", "commonName": "Korean blood-sucking leech", "taxonId": 42736, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49276.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Hirudinea", "Hirudinida", "Hirudiniformes", "Hirudinidae", "Hirudo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00198"}], "value": "SCP domain-containing protein"}}}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 195, "modifier": "EXACT"}}, "description": "SCP domain-containing protein", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042124943"}, {"type": "Domain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 168, "modifier": "EXACT"}}, "description": "SCP", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00198"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-ANPA6HQVADV17", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49276.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR759982", "properties": [{"key": "ProteinId", "value": "WPD49276.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.33.10", "properties": [{"key": "EntryName", "value": "CAP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR018244", "properties": [{"key": "EntryName", "value": "Allrgn_V5/Tpx1_CS"}]}, {"database": "InterPro", "id": "IPR014044", "properties": [{"key": "EntryName", "value": "CAP_dom"}]}, {"database": "InterPro", "id": "IPR035940", "properties": [{"key": "EntryName", "value": "CAP_sf"}]}, {"database": "InterPro", "id": "IPR001283", "properties": [{"key": "EntryName", "value": "CRISP-related"}]}, {"database": "PANTHER", "id": "PTHR10334", "properties": [{"key": "EntryName", "value": "CYSTEINE-RICH SECRETORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00188", "properties": [{"key": "EntryName", "value": "CAP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00837", "properties": [{"key": "EntryName", "value": "V5TPXLIKE"}]}, {"database": "SMART", "id": "SM00198", "properties": [{"key": "EntryName", "value": "SCP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55797", "properties": [{"key": "EntryName", "value": "PR-1-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01009", "properties": [{"key": "EntryName", "value": "CRISP_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01010", "properties": [{"key": "EntryName", "value": "CRISP_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKTLILIVTTLCLASGTLLSPEVERRVLDHHNKLRRGEGSSDMKEMKWDPTLAQTASMWADGCVFKHGHPTSVKTNYGYVGQNIFWSSSESVDAVDGIQKFFDEKKDYIYSQTKCRERAVCGHYTQVVWADSEYVGCAATVCSGKREEGKVSGTLMVCNYGPGGNYRGAKPFKVGRACSECETGYRCRNDLCYKP", "length": 195, "molWeight": 21739, "crc64": "0B75BCF9B54C9C48", "md5": "934A46B34E0912898F18B414A2551B01"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B2C0AC3"}, "cluster_size": 1, "family": "Hirudinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MKH6", "uniProtkbId": "A0AA96MKH6_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 9, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50092.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50092.1"}], "value": "Receptor-type tyrosine-protein phosphatase-like protein"}}]}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:10684"}, {"database": "Rhea", "id": "RHEA-COMP:10136"}, {"database": "Rhea", "id": "RHEA-COMP:20101"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:43474"}, {"database": "ChEBI", "id": "CHEBI:46858"}, {"database": "ChEBI", "id": "CHEBI:61978"}], "ecNumber": "3.1.3.48", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00051722"}]}}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 642, "modifier": "EXACT"}, "end": {"value": 666, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 39, "modifier": "EXACT"}, "end": {"value": 139, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 305, "modifier": "EXACT"}, "end": {"value": 399, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 401, "modifier": "EXACT"}, "end": {"value": 507, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 545, "modifier": "EXACT"}, "end": {"value": 635, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 722, "modifier": "EXACT"}, "end": {"value": 943, "modifier": "EXACT"}}, "description": "Tyrosine-protein phosphatase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50055"}]}, {"type": "Domain", "location": {"start": {"value": 859, "modifier": "EXACT"}, "end": {"value": 934, "modifier": "EXACT"}}, "description": "Tyrosine specific protein phosphatases", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50056"}]}, {"type": "Domain", "location": {"start": {"value": 975, "modifier": "EXACT"}, "end": {"value": 1234, "modifier": "EXACT"}}, "description": "Tyrosine-protein phosphatase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50055"}]}, {"type": "Domain", "location": {"start": {"value": 1150, "modifier": "EXACT"}, "end": {"value": 1225, "modifier": "EXACT"}}, "description": "Tyrosine specific protein phosphatases", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50056"}]}, {"type": "Region", "location": {"start": {"value": 387, "modifier": "EXACT"}, "end": {"value": 410, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 399, "modifier": "EXACT"}, "end": {"value": 410, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022912"}], "id": "KW-0904", "category": "Molecular function", "name": "Protein phosphatase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50092.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50092.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460169", "properties": [{"key": "ProteinId", "value": "WNS50092.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004725", "properties": [{"key": "GoTerm", "value": "F:protein tyrosine phosphatase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00063", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "CDD", "id": "cd00047", "properties": [{"key": "EntryName", "value": "PTPc"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Gene3D", "id": "3.90.190.10", "properties": [{"key": "EntryName", "value": "Protein tyrosine phosphatase superfamily"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR003961", "properties": [{"key": "EntryName", "value": "FN3_dom"}]}, {"database": "InterPro", "id": "IPR036116", "properties": [{"key": "EntryName", "value": "FN3_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR029021", "properties": [{"key": "EntryName", "value": "Prot-tyrosine_phosphatase-like"}]}, {"database": "InterPro", "id": "IPR050348", "properties": [{"key": "EntryName", "value": "Protein-Tyr_Phosphatase"}]}, {"database": "InterPro", "id": "IPR000242", "properties": [{"key": "EntryName", "value": "PTP_cat"}]}, {"database": "InterPro", "id": "IPR016130", "properties": [{"key": "EntryName", "value": "Tyr_Pase_AS"}]}, {"database": "InterPro", "id": "IPR003595", "properties": [{"key": "EntryName", "value": "Tyr_Pase_cat"}]}, {"database": "InterPro", "id": "IPR000387", "properties": [{"key": "EntryName", "value": "Tyr_Pase_dom"}]}, {"database": "PANTHER", "id": "PTHR19134", "properties": [{"key": "EntryName", "value": "RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR19134:SF449", "properties": [{"key": "EntryName", "value": "TYROSINE-PROTEIN PHOSPHATASE 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00041", "properties": [{"key": "EntryName", "value": "fn3"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Pfam", "id": "PF00102", "properties": [{"key": "EntryName", "value": "Y_phosphatase"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00014", "properties": [{"key": "EntryName", "value": "FNTYPEIII"}]}, {"database": "PRINTS", "id": "PR00700", "properties": [{"key": "EntryName", "value": "PRTYPHPHTASE"}]}, {"database": "SMART", "id": "SM00060", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "SMART", "id": "SM00194", "properties": [{"key": "EntryName", "value": "PTPc"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00404", "properties": [{"key": "EntryName", "value": "PTPc_motif"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF52799", "properties": [{"key": "EntryName", "value": "(Phosphotyrosine protein) phosphatases II"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF49265", "properties": [{"key": "EntryName", "value": "Fibronectin type III"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS50853", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS00383", "properties": [{"key": "EntryName", "value": "TYR_PHOSPHATASE_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50056", "properties": [{"key": "EntryName", "value": "TYR_PHOSPHATASE_2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50055", "properties": [{"key": "EntryName", "value": "TYR_PHOSPHATASE_PTP"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MSRAFDGLLPDTTYAIDCVEVDSEGKYLCKEYNHSVLTKPDAPLLRAIDVQSCKNVIVAWDAPHDNGGLPVQGYELHYYSDPTQELVVLNISGNTTERELDNLLPGTEYTFVIKATTSIATDNNNTLSNTTHFRGSADDILIATQNKSRMINITSKNGTPFVCWINRTRDEHENYTVNETTTVEGLQPDTLYSIDCVEINSKGEYQCRKFNTTLLTENLSIEMQPFSSTGAHLLIWPQYNNTVNYSCSLTALQAENYTKSTIELNNTLSELSPNTTYSVWCLVYEEDRERELCYEGRAEGRTFPLIENITATNITAASTVITWNTPPHNYNYTIWLESRVADNFTYWNSSIILTSPTSRSSYTLTDLDSFRNYSISMYLELSNLGNGTDSEEPFETQGKEPTSTPNNRTVNMDKKFATLQWRIPSISGRNGIITNYSINWRSHGSAQAQKSPIIYNLTNPSFTHPEDIRYTLSSLTPYTNYTWRVAAVNEKGVGPFSEWNNFTTDEDKAGVPYDVSVWAVTSAGPGNKTQYAETIFTKELTPNASVSDVVITWTGGDVVNISWEALPLRVARGNPQYTVNVTSRGVVVWSGAVNTSSVQVPGLSRTTVYSVVVRVSTLEGQGNYSEPVSFGTEPAEDSNVPVVAGIIAVVIAALAVVICIAVCIVVRRRRSRKVAIAPNEELPLRPLYRDNTEEPQGQRREPISRDNFCAHVKHMHQDKSKPFKDEFSSVLQAPDATHTAAQNNPLRNRYVNIYPCPIQSTVADFWEMIWEHKSPVIVMLTRLKEGDRPKCIQYWSEEINIPYEPGRNLSVVTTRMDTTPSYEMRHFEVTKTSEKSSPLKVKQFLYTAWPDHGVPQYSSSMVKFIMEQIRPEVQNSSAPIIVHCSAGAGRTGTLIAIDTTIDRLEEEEDINIFECVELMRARRTQMVQNVNQYMYIHDAINDYVSCGNTTIVAHELGPKIALLSTKNPGQDKTGYEQQFQALEDLSPVFSDADRSFALKAEAKDKIRYTDRFTYSDNCIRTEIKEKYVNATQIKGYYGQNHFIAAQAPMKKTVEDTWNVIREQDCKVVVVLCKLTDEDDAELEMSCIQFCPSEPGKTTSTDSYTFTALRVDQTAGYTTTEVSSVVEDEEPVLITVYQYKNWKKNGRPEVSSLLRLMGDVQRSLSSGGEGSLMVMCDDGMSRTGVFITVMSEIDRVKVEGEMDIFQTIKAARTARPYMVSTVVDYEVCHEIIHNYLESFDTYANFK", "length": 1245, "molWeight": 140136, "crc64": "945F289D1258EAAA", "md5": "FB49DDF9862657CB15A3CA8949B1C41B"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 8, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B323AF6"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBF0", "uniProtkbId": "A0AAU6PBF0_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20551.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20551.1"}], "value": "Venom peptide"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00124"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043537253"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20551.1"}], "value": "U_LCTX_10_Cm19", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20551.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480820", "properties": [{"key": "ProteinId", "value": "WXB20551.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043195", "properties": [{"key": "GoTerm", "value": "C:terminal bouton"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030297", "properties": [{"key": "GoTerm", "value": "F:transmembrane receptor protein tyrosine kinase activator activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043410", "properties": [{"key": "GoTerm", "value": "P:positive regulation of MAPK cascade"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00112", "properties": [{"key": "EntryName", "value": "LDLa"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.128.620", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036055", "properties": [{"key": "EntryName", "value": "LDL_receptor-like_sf"}]}, {"database": "InterPro", "id": "IPR023415", "properties": [{"key": "EntryName", "value": "LDLR_class-A_CS"}]}, {"database": "InterPro", "id": "IPR002172", "properties": [{"key": "EntryName", "value": "LDrepeatLR_classA_rpt"}]}, {"database": "PANTHER", "id": "PTHR21105", "properties": [{"key": "EntryName", "value": "GH16255P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21105:SF0", "properties": [{"key": "EntryName", "value": "GH16255P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00057", "properties": [{"key": "EntryName", "value": "Ldl_recept_a"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00192", "properties": [{"key": "EntryName", "value": "LDLa"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57424", "properties": [{"key": "EntryName", "value": "LDL receptor-like module"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01209", "properties": [{"key": "EntryName", "value": "LDLRA_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50068", "properties": [{"key": "EntryName", "value": "LDLRA_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNMNKILYLLFILTVIGIVYSDGPECPPAEDGTEKLACPTTDQKGRYRCIEGYVLCDGTNDCPNGEDEDLKDCMFFKTTLSYLNVISEAMLRSARS", "length": 96, "molWeight": 10727, "crc64": "979545F1DCE9DF97", "md5": "55774B4EFBF6B9E935387ABAF27D6EA6"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D33DD9"}, "cluster_size": 2, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2Y4", "uniProtkbId": "A0AA96S2Y4_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50044.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50044.1"}], "value": "Uncharacterized protein 5"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 41, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 61, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50044.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460121", "properties": [{"key": "ProteinId", "value": "WNS50044.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MKVMGKMLRSATTASLAQSRPRQTTTRPARRHDTLQRRQFVNQGRRAVALWRLVQRILKWIFKGPSPPDSSTETTTKPPKPESEETGRQTGSEDSPDADD", "length": 100, "molWeight": 11318, "crc64": "CB81FE0C765A01A7", "md5": "7072172DE48E5545D9627526F7D2DDC1"}, "extraAttributes": {"countByFeatureType": {"Region": 2, "Compositional bias": 1}, "uniParcId": "UPI002B27DB1F"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MNV9", "uniProtkbId": "A0AA96MNV9_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50095.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50095.1"}], "value": "Uncharacterized protein 23"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 338, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041726043"}, {"type": "Region", "location": {"start": {"value": 51, "modifier": "EXACT"}, "end": {"value": 130, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50095.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460172", "properties": [{"key": "ProteinId", "value": "WNS50095.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.20.5.320", "properties": [{"key": "EntryName", "value": "6-Phosphogluconate Dehydrogenase, domain 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008160", "properties": [{"key": "EntryName", "value": "Collagen"}]}, {"database": "PANTHER", "id": "PTHR24637", "properties": [{"key": "EntryName", "value": "COLLAGEN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01391", "properties": [{"key": "EntryName", "value": "Collagen"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSSLWSILSVLVLGLTSGVAGETNISAPSSRQCVANPSGSVKLDVDVVGVPGAPGPRGPQGVVGLMGPPCKGPKGSRGAEGVQGPRGERGEEGPIGSPGERGEGGARGPRGLAGERGVQGPKGDPGDTVLSDKEFQSMTAQVITEMKRYSKFMTPTWIYNNANFVNRNAIVSHDAKRLTLKSLQLHGLILTIPLSFDRCSRGEDVFKVTISLQTPSRDSDPYVGIGNAGGTVAAVWILEQRPNAILLQSLVPSSGNVYSPTKAEQSGGSTVPAPFDEESTFIYKPSEDFGAFYSGTAVVTGTFQHRPNMTDDVHLVLIGHNVNEIYKIQYIHVEITSS", "length": 338, "molWeight": 35673, "crc64": "F62D6C523EA21B5C", "md5": "BDF78978A34EC4FBF3B68E73B45AFA51"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1}, "uniParcId": "UPI002B2EB82F"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0MT79", "uniProtkbId": "A0AAU0MT79_UREUN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Urechis unicinctus", "commonName": "Fat innkeeper worm", "synonyms": ["Chinese penis fish"], "taxonId": 6432, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59932.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Echiura", "Xenopneusta", "Urechidae", "Urechis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00039893"}], "value": "Forkhead box protein O"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00089"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 70, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Fork-head", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50039"}]}, {"type": "DNA binding", "location": {"start": {"value": 70, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Fork-head", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00089"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 64, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 148, "modifier": "EXACT"}, "end": {"value": 179, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 317, "modifier": "EXACT"}, "end": {"value": 434, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 447, "modifier": "EXACT"}, "end": {"value": 481, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 541, "modifier": "EXACT"}, "end": {"value": 561, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 13, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 326, "modifier": "EXACT"}, "end": {"value": 342, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 356, "modifier": "EXACT"}, "end": {"value": 367, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 375, "modifier": "EXACT"}, "end": {"value": 388, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 425, "modifier": "EXACT"}, "end": {"value": 434, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 449, "modifier": "EXACT"}, "end": {"value": 471, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 472, "modifier": "EXACT"}, "end": {"value": 481, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00089"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022604"}], "id": "KW-0341", "category": "Biological process", "name": "Growth regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00089"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022553"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FQL9M4QGPVUS3", "citationType": "submission", "authors": ["Liu D.D."], "publicationDate": "FEB-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59932.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OM809793", "properties": [{"key": "ProteinId", "value": "WOS59932.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd20061", "properties": [{"key": "EntryName", "value": "FH_FOXO3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.10.10:FF:000032", "properties": [{"key": "EntryName", "value": "Forkhead box protein O4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.10.10", "properties": [{"key": "EntryName", "value": "Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001766", "properties": [{"key": "EntryName", "value": "Fork_head_dom"}]}, {"database": "InterPro", "id": "IPR032067", "properties": [{"key": "EntryName", "value": "FOXO-TAD"}]}, {"database": "InterPro", "id": "IPR030456", "properties": [{"key": "EntryName", "value": "TF_fork_head_CS_2"}]}, {"database": "InterPro", "id": "IPR036388", "properties": [{"key": "EntryName", "value": "WH-like_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR036390", "properties": [{"key": "EntryName", "value": "WH_DNA-bd_sf"}]}, {"database": "PANTHER", "id": "PTHR45767", "properties": [{"key": "EntryName", "value": "FORKHEAD BOX PROTEIN O"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45767:SF2", "properties": [{"key": "EntryName", "value": "FORKHEAD BOX PROTEIN O"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00250", "properties": [{"key": "EntryName", "value": "Forkhead"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF16676", "properties": [{"key": "EntryName", "value": "FOXO-TAD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00053", "properties": [{"key": "EntryName", "value": "FORKHEAD"}]}, {"database": "SMART", "id": "SM00339", "properties": [{"key": "EntryName", "value": "FH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF46785", "properties": [{"key": "EntryName", "value": "Winged helix' DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00658", "properties": [{"key": "EntryName", "value": "FORK_HEAD_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50039", "properties": [{"key": "EntryName", "value": "FORK_HEAD_3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEIEVADIDPNFEPQTRCRSNTWPLRPREFTKEEENRSTPSSTEGEIHPEPPKPDPLGLAKKTSSRRNAWGNLSYADLITKAIESSPEKRLTLSQIYDWMVQNVPYFKDKGESNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWVINPDAKPGKTPRRRATSMDTKAYEKKRGRVKKKVEALRAELHSQSNPGSDFGDSANDLNLSDNFNLSPQGFRARTSSNASSIGGRLSPIQAGIEPEMTDSQVSSMSPLPWGVQSGGMTPSAAGYTSQDGFTETLSQSLAEMFVGQDLPNLSPDSSMTAMSDLSLKAMATTSPSPLNHQSQISSSFQQQQPQSYLPAPPPPYPDQLRTSPEQISSSQPSPLNGCSTVNSSMSGLNGSSMGGPRMPTQGRGMRSLPQSLSDLLRDSPPPPSSTAEYVGNGSQDVELSSSAGSHFTTLASFPNQQQQQQRQRASQHSTLQQLLSQHMAAQQTGGSRQHNIVGLSNSLLRQALTQKAQLQLASQLQQQQQQQQQQQQIQQQLQQRSMQLGLQELLQQSPPQQQAHLSQPQQPGAQAQSLIGLQQPPQLSQHLMCGGSVLSTSSAMPLDAPNMPTDLLNFDDAKPSDLECDVDQIIKHELSMDGSLDFNFESAPSTEAQPTSQYNTILT", "length": 652, "molWeight": 71318, "crc64": "695976D852381C88", "md5": "F56FC68F03403DF234C854F379236D0F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "DNA binding": 1, "Region": 5, "Compositional bias": 8}, "uniParcId": "UPI0035D2895C"}, "cluster_size": 1, "family": "Urechidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DY03", "uniProtkbId": "NDBP7_EUSVA", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Euscorpiops validus", "commonName": "Scorpion", "taxonId": 1643527, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Scorpiones", "Iurida", "Chactoidea", "Euscorpiidae", "Scorpiopinae", "Scorpiopini", "Euscorpiops"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "29290802"}], "value": "Antimicrobial peptide Eval967"}}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "29290802"}], "value": "Probable antimicrobial peptide. Has no inhibitory activity against herpes simplex virus type 1 (HSV-1)"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "29290802"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "29290802"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Peptide", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 36, "modifier": "EXACT"}}, "description": "Antimicrobial peptide Eval967", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "29290802"}], "featureId": "PRO_0000461883"}, {"type": "Propeptide", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "29290802"}], "featureId": "PRO_0000461884"}, {"type": "Modified residue", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 36, "modifier": "EXACT"}}, "description": "Leucine amide", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "29290802"}]}], "keywords": [{"id": "KW-0027", "category": "PTM", "name": "Amidation"}, {"id": "KW-0929", "category": "Molecular function", "name": "Antimicrobial"}, {"id": "KW-0165", "category": "PTM", "name": "Cleavage on pair of basic residues"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "29290802", "citationType": "journal article", "authors": ["Zeng Z.", "Zhang R.", "Hong W.", "Cheng Y.", "Wang H.", "Lang Y.", "Ji Z.", "Wu Y.", "Li W.", "Xie Y.", "Cao Z."], "citationCrossReferences": [{"database": "PubMed", "id": "29290802"}, {"database": "DOI", "id": "10.7150/thno.21425"}], "title": "Histidine-rich modification of a scorpion-derived peptide improves bioavailability and inhibitory activity against HSV-1.", "publicationDate": "2018", "journal": "Theranostics", "firstPage": "199", "lastPage": "211", "volume": "8"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "SYNTHESIS OF 23-36", "PROBABLE AMIDATION AT LEU-36"], "referenceComments": [{"value": "Venom gland", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}], "sequence": {"value": "MKFSALLPVFFLLLAVIDYCQAFAFLAAIPSILSALGKRDVKTQKYVDIKRRDLDLDDMLSKLFED", "length": 66, "molWeight": 7542, "crc64": "ED451879DF124720", "md5": "9E204FCF9D60A4542D3B265690FAA515"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Peptide": 1, "Propeptide": 1, "Modified residue": 1}, "uniParcId": "UPI00388C33AF"}, "cluster_size": 2, "family": "Euscorpiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QKU9", "uniProtkbId": "A0AAU0QKU9_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56462.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56462.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 84, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56462.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56462.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56462.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56462.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970355", "properties": [{"key": "ProteinId", "value": "WPO56462.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "NEQVSDKNAVERLKECYRRHVELMKFSRLFDSCLSPIMLLYMFVCSVMLCVTAYQITSETSAMQRFLTTEYLVFGIAQLFIYCWHSNDVLYASLQLSEGPYESIWWCKNLSHRRNLYTLTDQFRRVVVFSAGPFNKLTVATFISVCIMQLIS", "length": 152, "molWeight": 17803, "crc64": "AE963AC4E799336A", "md5": "603CB3487F049559D71AE79F8A2D4A9A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 1}, "uniParcId": "UPI00308C1935"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHG9", "uniProtkbId": "A0AAQ5BHG9_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519351.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519351.1"}], "value": "Alpha glucosidase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519351.1"}], "value": "GAA"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00779"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 80, "modifier": "EXACT"}, "end": {"value": 131, "modifier": "EXACT"}}, "description": "P-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51448"}]}, {"type": "Region", "location": {"start": {"value": 47, "modifier": "EXACT"}, "end": {"value": 82, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 226, "modifier": "EXACT"}, "end": {"value": 248, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 271, "modifier": "EXACT"}, "end": {"value": 296, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 234, "modifier": "EXACT"}, "end": {"value": 245, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 286, "modifier": "EXACT"}, "end": {"value": 296, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHG9"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHG9"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519351.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519351.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16625196", "citationType": "journal article", "authors": ["Zody M.C.", "Garber M.", "Adams D.J.", "Sharpe T.", "Harrow J.", "Lupski J.R.", "Nicholson C.", "Searle S.M.", "Wilming L.", "Young S.K.", "Abouelleil A.", "Allen N.R.", "Bi W.", "Bloom T.", "Borowsky M.L.", "Bugalter B.E.", "Butler J.", "Chang J.L.", "Chen C.K.", "Cook A.", "Corum B.", "Cuomo C.A.", "de Jong P.J.", "DeCaprio D.", "Dewar K.", "FitzGerald M.", "Gilbert J.", "Gibson R.", "Gnerre S.", "Goldstein S.", "Grafham D.V.", "Grocock R.", "Hafez N.", "Hagopian D.S.", "Hart E.", "Norman C.H.", "Humphray S.", "Jaffe D.B.", "Jones M.", "Kamal M.", "Khodiyar V.K.", "LaButti K.", "Laird G.", "Lehoczky J.", "Liu X.", "Lokyitsang T.", "Loveland J.", "Lui A.", "Macdonald P.", "Major J.E.", "Matthews L.", "Mauceli E.", "McCarroll S.A.", "Mihalev A.H.", "Mudge J.", "Nguyen C.", "Nicol R.", "O'Leary S.B.", "Osoegawa K.", "Schwartz D.C.", "Shaw-Smith C.", "Stankiewicz P.", "Steward C.", "Swarbreck D.", "Venkataraman V.", "Whittaker C.A.", "Yang X.", "Zimmer A.R.", "Bradley A.", "Hubbard T.", "Birren B.W.", "Rogers J.", "Lander E.S.", "Nusbaum C."], "citationCrossReferences": [{"database": "PubMed", "id": "16625196"}, {"database": "DOI", "id": "10.1038/nature04689"}], "title": "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.", "publicationDate": "2006", "journal": "Nature", "firstPage": "1045", "lastPage": "1049", "volume": "440"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519351.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519351.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC087741", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHG9", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714061.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519351.1"}, {"key": "GeneId", "value": "ENSG00000171298.15"}]}, {"database": "HGNC", "id": "HGNC:4065", "properties": [{"key": "GeneName", "value": "GAA"}]}, {"database": "OpenTargets", "id": "ENSG00000171298", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000159355", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 17"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00111", "properties": [{"key": "EntryName", "value": "Trefoil"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "4.10.110.10:FF:000007", "properties": [{"key": "EntryName", "value": "Lysosomal alpha-glucosidase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.1760", "properties": [{"key": "EntryName", "value": "glycosyl hydrolase (family 31)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "4.10.110.10", "properties": [{"key": "EntryName", "value": "Spasmolytic Protein, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR017994", "properties": [{"key": "EntryName", "value": "P_trefoil_chordata"}]}, {"database": "InterPro", "id": "IPR017957", "properties": [{"key": "EntryName", "value": "P_trefoil_CS"}]}, {"database": "InterPro", "id": "IPR000519", "properties": [{"key": "EntryName", "value": "P_trefoil_dom"}]}, {"database": "InterPro", "id": "IPR044913", "properties": [{"key": "EntryName", "value": "P_trefoil_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR13826", "properties": [{"key": "EntryName", "value": "INTESTINAL TREFOIL FACTOR-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13826:SF14", "properties": [{"key": "EntryName", "value": "TREFOIL FACTOR 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00088", "properties": [{"key": "EntryName", "value": "Trefoil"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00018", "properties": [{"key": "EntryName", "value": "PD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57492", "properties": [{"key": "EntryName", "value": "Trefoil"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00025", "properties": [{"key": "EntryName", "value": "P_TREFOIL_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51448", "properties": [{"key": "EntryName", "value": "P_TREFOIL_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGASRPGPRDAQAHPGRPRAVPTQCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGLQGAQMGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLHFTVGRAGAGAAARAEGARGHRHPRTSQGWGACCTTVCWALAGSGGVSRQWQRPSGSSGDTTVTGTPEGRARGSFIFMKRSKIQLTGATRCPWRPRMSTAGHRPHSTAWSSPRSPSG", "length": 296, "molWeight": 31932, "crc64": "7A33284561C7EEC6", "md5": "E83860CAAD51B23AA3F470F8FDCEBF4E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1, "Region": 3, "Compositional bias": 2}, "uniParcId": "UPI0032C8D4A4"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HDL4", "uniProtkbId": "A0AA96HDL4_9METZ", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Kirkpatrickia variolosa", "taxonId": 1631157, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25254.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Heteroscleromorpha", "Poecilosclerida", "Hymedesmiidae", "Kirkpatrickia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25254.1"}], "value": "Hypoxia-inducible factor 1"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Region", "location": {"start": {"value": 169, "modifier": "EXACT"}, "end": {"value": 217, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 232, "modifier": "EXACT"}, "end": {"value": 266, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 194, "modifier": "EXACT"}, "end": {"value": 211, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 237, "modifier": "EXACT"}, "end": {"value": 266, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25254.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 266, "modifier": "EXACT"}, "end": {"value": 266, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25254.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25254.1"}], "value": "Kirpa1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25254.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354989", "properties": [{"key": "ProteinId", "value": "WNN25254.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14598", "properties": [{"key": "EntryName", "value": "PAS_11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VVFCKLATISKLREMVVGTFFKTKHSLDLSYTKVDTRIRWILGYDPSEMTGLKAYQYFHPQDLGVTSSCHMNLLSRGVSHSPCYRFMTRWGDWVWCRSKSQMVFNKNSHLPEGIVIYTWIVKVDEEDDRMLAIKNGEDGESKRKTYDNFSSNISSSGGSVDVSALANPFKKPLKTQTPPPETTPSPKEASKVIYEPSLPYSPPLSAESSPLKGQRRLPSDCAYQAEDVATPPMMAVSSPPMGISSPPIGVNASSPPMGMGISSPPM", "length": 266, "molWeight": 29392, "crc64": "27F9CEEA36A9A2BE", "md5": "A26FF47C98D852E41DE14AA7A5E3CDA5"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Region": 2, "Compositional bias": 2, "Non-terminal residue": 2}, "uniParcId": "UPI002B2D836C"}, "cluster_size": 1, "family": "Hymedesmiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7BNB7", "uniProtkbId": "A0AAU7BNB7_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33945.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33945.1"}], "value": "Ribosomal protein S6 kinase A6"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33945.1"}], "value": "RPS6KA6"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006692"}], "value": "Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 177, "modifier": "EXACT"}}, "description": "Protein kinase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50011"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 28, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022777"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33945.1"}], "id": "KW-0418", "category": "Molecular function", "name": "Kinase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022527"}], "id": "KW-0723", "category": "Molecular function", "name": "Serine/threonine-protein kinase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "38560189", "citationType": "journal article", "authors": ["Qin Z.", "Yang J.", "Zhang K.", "Gao X.", "Ran Q.", "Xu Y.", "Wang Z.", "Lou D.", "Huang C.", "Zellmer L.", "Meng G.", "Chen N.", "Ma H.", "Wang Z.", "Liao D.J."], "citationCrossReferences": [{"database": "PubMed", "id": "38560189"}], "title": "Updating mRNA variants of the human RSK4 gene and their expression in different stressed situations.", "publicationDate": "2024", "journal": "Heliyon", "firstPage": "0", "lastPage": "0", "volume": "10"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33945.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8A9UVL1DNNG5C", "citationType": "submission", "authors": ["Qin Z.W.", "Yang J.L.", "Zhang K.Y.", "Gao X.", "Ran Q.C.", "Xu Y.H.", "Wang Z.", "Lou D.D.", "Huang C.H.", "Zellmer L.", "Meng G.X.", "Chen N.", "Ma H.", "Wang Z.", "Liao D.J."], "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33945.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP796816", "properties": [{"key": "ProteinId", "value": "XBG33945.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "PeptideAtlas", "id": "A0AAU7BNB7", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004674", "properties": [{"key": "GoTerm", "value": "F:protein serine/threonine kinase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.30.200.20", "properties": [{"key": "EntryName", "value": "Phosphorylase Kinase, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.510.10", "properties": [{"key": "EntryName", "value": "Transferase(Phosphotransferase) domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050205", "properties": [{"key": "EntryName", "value": "CDPK_Ser/Thr_kinases"}]}, {"database": "InterPro", "id": "IPR011009", "properties": [{"key": "EntryName", "value": "Kinase-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR000719", "properties": [{"key": "EntryName", "value": "Prot_kinase_dom"}]}, {"database": "PANTHER", "id": "PTHR24349", "properties": [{"key": "EntryName", "value": "SERINE/THREONINE-PROTEIN KINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00069", "properties": [{"key": "EntryName", "value": "Pkinase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00220", "properties": [{"key": "EntryName", "value": "S_TKc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56112", "properties": [{"key": "EntryName", "value": "Protein kinase-like (PK-like)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50011", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_DOM"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 239, "molWeight": 26396, "crc64": "8522F6E87BCF7A6E", "md5": "AE3E9C57F4A1132CA5A53D698B053462"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Region": 1}, "uniParcId": "UPI0035D2C0A1"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N8N9", "uniProtkbId": "A0AAN0N8N9_DUGJA", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Dugesia japonica", "commonName": "Planarian", "taxonId": 6161, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL62549.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Platyhelminthes", "Rhabditophora", "Seriata", "Tricladida", "Continenticola", "Geoplanoidea", "Dugesiidae", "Dugesia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL62549.1"}], "value": "Collagen alpha-4 like protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL62549.1"}], "value": "col-4"}}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 129, "modifier": "EXACT"}, "end": {"value": 302, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL62549.1"}], "id": "KW-0176", "category": "Domain", "name": "Collagen"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1VQB2TO5IHBRB", "citationType": "submission", "authors": ["Ma K."], "title": "Identification of a collagen alpha-4 like gene in planarian Dugesia japonica.", "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL62549.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP680535", "properties": [{"key": "ProteinId", "value": "WZL62549.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005581", "properties": [{"key": "GoTerm", "value": "C:collagen trimer"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00198", "properties": [{"key": "EntryName", "value": "vWFA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF20", "properties": [{"key": "EntryName", "value": "PH DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00453", "properties": [{"key": "EntryName", "value": "VWFADOMAIN"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MIKDVESTKNQNGLTAIGKAVNLTLVELLPMMRPDADKLVILFTDGTNNKYPAPYIYADKLKDAGVKILTIGIGSDINNKELGTLASPGLSVTFDSFSRLVNSQNQILSHICPIPDPPLEVPCKRTKLDLVVVLDSSASISNEDYDSAKRFIAKIFGKLELGPNKGRVAMISFSNDPRLDFSFEDYYDNKKLDLKLRNLERFGGLTGIGKALQEVQSKLMPKQRSKVPFNILLITDGVNNIYPRPYGVANALKQNKANIITLGIGSDINLNELKALSSNDKVLTVDSFDELEASLKTIFETVICGNAQ", "length": 308, "molWeight": 33810, "crc64": "3DA97B11C0C2E0D3", "md5": "833A65C23E36CEC198C3447C4246ACC7"}, "extraAttributes": {"countByFeatureType": {"Domain": 2}, "uniParcId": "UPI003246483B"}, "cluster_size": 1, "family": "Dugesiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BGI2", "uniProtkbId": "A0AAQ5BGI2_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518915.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518915.1"}], "value": "Activin A receptor like type 1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518915.1"}], "value": "ACVRL1"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 223, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042917520"}, {"type": "Transmembrane", "location": {"start": {"value": 119, "modifier": "EXACT"}, "end": {"value": 141, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 194, "modifier": "EXACT"}, "end": {"value": 223, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 195, "modifier": "EXACT"}, "end": {"value": 223, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BGI2"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BGI2"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518915.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518915.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16541075", "citationType": "journal article", "authoringGroup": ["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"], "authors": ["Scherer S.E.", "Muzny D.M.", "Buhay C.J.", "Chen R.", "Cree A.", "Ding Y.", "Dugan-Rocha S.", "Gill R.", "Gunaratne P.", "Harris R.A.", "Hawes A.C.", "Hernandez J.", "Hodgson A.V.", "Hume J.", "Jackson A.", "Khan Z.M.", "Kovar-Smith C.", "Lewis L.R.", "Lozado R.J.", "Metzker M.L.", "Milosavljevic A.", "Miner G.R.", "Montgomery K.T.", "Morgan M.B.", "Nazareth L.V.", "Scott G.", "Sodergren E.", "Song X.Z.", "Steffen D.", "Lovering R.C.", "Wheeler D.A.", "Worley K.C.", "Yuan Y.", "Zhang Z.", "Adams C.Q.", "Ansari-Lari M.A.", "Ayele M.", "Brown M.J.", "Chen G.", "Chen Z.", "Clerc-Blankenburg K.P.", "Davis C.", "Delgado O.", "Dinh H.H.", "Draper H.", "Gonzalez-Garay M.L.", "Havlak P.", "Jackson L.R.", "Jacob L.S.", "Kelly S.H.", "Li L.", "Li Z.", "Liu J.", "Liu W.", "Lu J.", "Maheshwari M.", "Nguyen B.V.", "Okwuonu G.O.", "Pasternak S.", "Perez L.M.", "Plopper F.J.", "Santibanez J.", "Shen H.", "Tabor P.E.", "Verduzco D.", "Waldron L.", "Wang Q.", "Williams G.A.", "Zhang J.", "Zhou J.", "Allen C.C.", "Amin A.G.", "Anyalebechi V.", "Bailey M.", "Barbaria J.A.", "Bimage K.E.", "Bryant N.P.", "Burch P.E.", "Burkett C.E.", "Burrell K.L.", "Calderon E.", "Cardenas V.", "Carter K.", "Casias K.", "Cavazos I.", "Cavazos S.R.", "Ceasar H.", "Chacko J.", "Chan S.N.", "Chavez D.", "Christopoulos C.", "Chu J.", "Cockrell R.", "Cox C.D.", "Dang M.", "Dathorne S.R.", "David R.", "Davis C.M.", "Davy-Carroll L.", "Deshazo D.R.", "Donlin J.E.", "D'Souza L.", "Eaves K.A.", "Egan A.", "Emery-Cohen A.J.", "Escotto M.", "Flagg N.", "Forbes L.D.", "Gabisi A.M.", "Garza M.", "Hamilton C.", "Henderson N.", "Hernandez O.", "Hines S.", "Hogues M.E.", "Huang M.", "Idlebird D.G.", "Johnson R.", "Jolivet A.", "Jones S.", "Kagan R.", "King L.M.", "Leal B.", "Lebow H.", "Lee S.", "LeVan J.M.", "Lewis L.C.", "London P.", "Lorensuhewa L.M.", "Loulseged H.", "Lovett D.A.", "Lucier A.", "Lucier R.L.", "Ma J.", "Madu R.C.", "Mapua P.", "Martindale A.D.", "Martinez E.", "Massey E.", "Mawhiney S.", "Meador M.G.", "Mendez S.", "Mercado C.", "Mercado I.C.", "Merritt C.E.", "Miner Z.L.", "Minja E.", "Mitchell T.", "Mohabbat F.", "Mohabbat K.", "Montgomery B.", "Moore N.", "Morris S.", "Munidasa M.", "Ngo R.N.", "Nguyen N.B.", "Nickerson E.", "Nwaokelemeh O.O.", "Nwokenkwo S.", "Obregon M.", "Oguh M.", "Oragunye N.", "Oviedo R.J.", "Parish B.J.", "Parker D.N.", "Parrish J.", "Parks K.L.", "Paul H.A.", "Payton B.A.", "Perez A.", "Perrin W.", "Pickens A.", "Primus E.L.", "Pu L.L.", "Puazo M.", "Quiles M.M.", "Quiroz J.B.", "Rabata D.", "Reeves K.", "Ruiz S.J.", "Shao H.", "Sisson I.", "Sonaike T.", "Sorelle R.P.", "Sutton A.E.", "Svatek A.F.", "Svetz L.A.", "Tamerisa K.S.", "Taylor T.R.", "Teague B.", "Thomas N.", "Thorn R.D.", "Trejos Z.Y.", "Trevino B.K.", "Ukegbu O.N.", "Urban J.B.", "Vasquez L.I.", "Vera V.A.", "Villasana D.M.", "Wang L.", "Ward-Moore S.", "Warren J.T.", "Wei X.", "White F.", "Williamson A.L.", "Wleczyk R.", "Wooden H.S.", "Wooden S.H.", "Yen J.", "Yoon L.", "Yoon V.", "Zorrilla S.E.", "Nelson D.", "Kucherlapati R.", "Weinstock G.", "Gibbs R.A.", "null."], "citationCrossReferences": [{"database": "PubMed", "id": "16541075"}, {"database": "DOI", "id": "10.1038/nature04569"}], "title": "The finished DNA sequence of human chromosome 12.", "publicationDate": "2006", "journal": "Nature", "firstPage": "346", "lastPage": "351", "volume": "440"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518915.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518915.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC025259", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BGI2", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000713618.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518915.1"}, {"key": "GeneId", "value": "ENSG00000139567.14"}]}, {"database": "HGNC", "id": "HGNC:175", "properties": [{"key": "GeneName", "value": "ACVRL1"}]}, {"database": "OpenTargets", "id": "ENSG00000139567", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000161446", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 12"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd23534", "properties": [{"key": "EntryName", "value": "TFP_LU_ECD_ALK1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.10.60.10:FF:000014", "properties": [{"key": "EntryName", "value": "Serine/threonine-protein kinase receptor R3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.10.60.10", "properties": [{"key": "EntryName", "value": "CD59"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR045860", "properties": [{"key": "EntryName", "value": "Snake_toxin-like_sf"}]}, {"database": "SUPFAM", "id": "SSF57302", "properties": [{"key": "EntryName", "value": "Snake toxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGEKAAMAKCGGACGTVRVWPSRSSPRGMNSPGSGRLRSITQCCSDTTTS", "length": 223, "molWeight": 23953, "crc64": "CADE3DE111CD24EA", "md5": "14771E36518D9CDBBF53C2482423229F"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0032CF8F3B"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAG2UWH5", "uniProtkbId": "A0AAG2UWH5_HUMAN", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518221.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518221.1"}], "value": "ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518221.1"}], "value": "ABO"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001936"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004606"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004606"}], "value": "Single-pass type II membrane protein", "id": "SL-9906"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042459451"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAG2UWH5"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAG2UWH5"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022968"}], "id": "KW-0735", "category": "Domain", "name": "Signal-anchor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022968"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518221.1"}]}], "uniProtKBCrossReferences": [{"database": "SMR", "id": "A0AAG2UWH5", "properties": [{"key": "Description", "value": "-"}]}, {"database": "PeptideAtlas", "id": "A0AAG2UWH5", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000710350.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518221.1"}, {"key": "GeneId", "value": "ENSG00000281879.5"}]}, {"database": "HGNC", "id": "HGNC:79", "properties": [{"key": "GeneName", "value": "ABO"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Unplaced"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR005076", "properties": [{"key": "EntryName", "value": "Glyco_trans_6"}]}, {"database": "Pfam", "id": "PF03414", "properties": [{"key": "EntryName", "value": "Glyco_transf_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPW", "length": 61, "molWeight": 7001, "crc64": "D7ADD40BD4A4AC5F", "md5": "A4272428DD43CE8D1EE85A16209D5958"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0026454779"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXW5", "uniProtkbId": "TXU34_MEGOP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Megalopyge opercularis", "commonName": "Southern flannel moth", "synonyms": ["Phalaena opercularis"], "taxonId": 1113279, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Megalopygidae", "Megalopyge"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-megalopygitoxin(3)-Mo4"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-MPTX(3)-Mo4"}, {"evidences": [{"evidenceCode": "ECO:0000312", "source": "EMBL", "id": "WJJ70367.1"}], "value": "U-MPTX.3-4"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Probable toxin"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Expressed by the venom apparatus"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Larvae"}], "commentType": "DEVELOPMENTAL STAGE"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "value": "Contains 3 disulfide bonds"}], "commentType": "PTM"}, {"commentType": "MASS SPECTROMETRY", "method": "MALDI", "molWeight": 6872.12, "molWeightError": 0.0, "note": "Monoisotopic mass.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the caterpillar 3 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 81, "modifier": "EXACT"}}, "description": "U-megalopygitoxin(3)-Mo4", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "featureId": "PRO_0000461523"}], "keywords": [{"id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "37428925", "citationType": "journal article", "authors": ["Walker A.A.", "Robinson S.D.", "Merritt D.J.", "Cardoso F.C.", "Goudarzi M.H.", "Mercedes R.S.", "Eagles D.A.", "Cooper P.", "Zdenek C.N.", "Fry B.G.", "Hall D.W.", "Vetter I.", "King G.F."], "citationCrossReferences": [{"database": "PubMed", "id": "37428925"}, {"database": "DOI", "id": "10.1073/pnas.2305871120"}], "title": "Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).", "publicationDate": "2023", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "e2305871120", "lastPage": "e2305871120", "volume": "120"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "MASS SPECTROMETRY", "RECOMBINANT EXPRESSION", "SUBCELLULAR LOCATION", "TISSUE SPECIFICITY", "DEVELOPMENTAL STAGE"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP514849", "properties": [{"key": "ProteinId", "value": "WJJ70367.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00104", "properties": [{"key": "EntryName", "value": "KAZAL_FS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.60.30", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002350", "properties": [{"key": "EntryName", "value": "Kazal_dom"}]}, {"database": "InterPro", "id": "IPR036058", "properties": [{"key": "EntryName", "value": "Kazal_dom_sf"}]}, {"database": "Pfam", "id": "PF07648", "properties": [{"key": "EntryName", "value": "Kazal_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF100895", "properties": [{"key": "EntryName", "value": "Kazal-type serine protease inhibitors"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNSKFVLIVVFLAVVSICFANEVWDPEKCGCPPFDKVENAVCTKDRATYDNRCQFDCHAKFLSKSGKTLEESPCIESADPK", "length": 81, "molWeight": 9065, "crc64": "448FFF963FB02F44", "md5": "20549CC139F4DB8886A4095E5AD5F7BD"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "DEVELOPMENTAL STAGE": 1, "PTM": 1, "MASS SPECTROMETRY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C338D"}, "cluster_size": 2, "family": "Megalopygidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7BBE0", "uniProtkbId": "A0AAU7BBE0_9NEOB", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Dyscophus guineti", "commonName": "Sambava tomato frog", "taxonId": 111069, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44906.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Microhyloidea", "Microhylidae", "Dyscophinae", "Dyscophus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "value": "Galectin"}}}, "features": [{"type": "Domain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 145, "modifier": "EXACT"}}, "description": "Galectin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51304"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022734"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "id": "KW-0430", "category": "Ligand", "name": "Lectin"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9LKRFH5MKF7BD", "citationType": "submission", "authors": ["Zaman S.", "Roelants K."], "title": "Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.", "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44906.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR480786", "properties": [{"key": "ProteinId", "value": "XBE44906.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005829", "properties": [{"key": "GoTerm", "value": "C:cytosol"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030246", "properties": [{"key": "GoTerm", "value": "F:carbohydrate binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0016936", "properties": [{"key": "GoTerm", "value": "F:galactoside binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:2000562", "properties": [{"key": "GoTerm", "value": "P:negative regulation of CD4-positive, alpha-beta T cell proliferation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0032689", "properties": [{"key": "GoTerm", "value": "P:negative regulation of type II interferon production"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0010628", "properties": [{"key": "GoTerm", "value": "P:positive regulation of gene expression"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00070", "properties": [{"key": "EntryName", "value": "GLECT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.60.120.200:FF:000124", "properties": [{"key": "EntryName", "value": "Galectin-4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.200", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR013320", "properties": [{"key": "EntryName", "value": "ConA-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR044156", "properties": [{"key": "EntryName", "value": "Galectin-like"}]}, {"database": "InterPro", "id": "IPR001079", "properties": [{"key": "EntryName", "value": "Galectin_CRD"}]}, {"database": "PANTHER", "id": "PTHR11346", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11346:SF188", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00337", "properties": [{"key": "EntryName", "value": "Gal-bind_lectin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00908", "properties": [{"key": "EntryName", "value": "Gal-bind_lectin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00276", "properties": [{"key": "EntryName", "value": "GLECT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49899", "properties": [{"key": "EntryName", "value": "Concanavalin A-like lectins/glucanases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51304", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAGTPGYRIIYDPTLPFKAFMGTTFDNGRYLIACGRVSNGADRFKIDLMNGKTGNIAFHFNPRFNQGAIVRNTCIQNSWGTEELELESMPFGPGDNFEVEIRNEGPCFGVYSNGEKIINYNHRLSACEIDTLVIAGDVVMNSVQF", "length": 145, "molWeight": 16129, "crc64": "60EAC85BD382B0B5", "md5": "99562376F2F1C361B1E4B1EEA5CF70D7"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D2B838"}, "cluster_size": 1, "family": "Microhylidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9TYI9", "uniProtkbId": "A0AAT9TYI9_9HEMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Eocanthecona furcellata", "taxonId": 696902, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83466.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Pentatomomorpha", "Pentatomoidea", "Pentatomidae", "Asopinae", "Eocanthecona"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83466.1"}], "value": "Odorant-binding protein 1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83466.1"}], "value": "OBP1"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043367034"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4EEV3RJ5PT5SU", "citationType": "submission", "authors": ["Pan Y.", "Chen W."], "publicationDate": "OCT-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83466.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP575945", "properties": [{"key": "ProteinId", "value": "WGJ83466.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAKFFLVILAICFLGASGVRFTEDKVAFKNATWKKCQEQENAPDEGMKEFYAFNSMEGLKDHKCAVKCINEEYGLYLKNGTISRPRLVQIIHYLSKDPKTRENLIATTDECIASVADQASSGIVRKNCINCKHSTYKQTCFQPCTPPSYQRIRGIA", "length": 156, "molWeight": 17628, "crc64": "0C8AC3E241DFA210", "md5": "622539991A9213AC4CBDAA2089F61BCD"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D29ABE"}, "cluster_size": 1, "family": "Pentatomidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHB2", "uniProtkbId": "A0AAN0LHB2_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34099.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34099.1"}], "value": "Ligated ion channel binding I - glutamate"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 119, "modifier": "EXACT"}, "end": {"value": 141, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 147, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 175, "modifier": "EXACT"}, "end": {"value": 191, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34099.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155025", "properties": [{"key": "ProteinId", "value": "WRW34099.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNYTVRIAIPEIKPYIVINNDKIFSQYELFYELISLLPTFKKKIIGLEYRLGTKNETGHYNGMIGKLQNDEVDLIYYPLPIDMSDPPGFLTKVFFESSTYIMNLANIPLDKHKDLFNSLFNLNLEIIFLFLFFLIFLSVFTSQVLKLFFSFFEALFFLLCLTFKKSIAINYKFRAFSYSMILYSFILMTIFESNVNSNLIIKVKTNIIDSIDDLYAKVDNLPIFFKDHFTTYYFNSPYSNKKFKVVYQRALNCKDCIKTIEEHMSQFVSPTNDNLKKKVFILDQTMIKLFKNIVCTFHHEKINSLGFLHTSSYIFKNQFGYLMNRKISFFHRKEINKRLTDVLESGIIIKVFENVDNLSPLGKKQYNLSIEKCLKSNDKYTNKIIEKKLNTVKLFDSIKMTNSN", "length": 404, "molWeight": 47604, "crc64": "A1E2AF22AAFCDEA0", "md5": "217D5A2538319A692DC43E242E5768B8"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 3}, "uniParcId": "UPI00324BA6F0"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39IUS1", "uniProtkbId": "A0AB39IUS1_9MICR", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ameson portunus", "taxonId": 1477415, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDL39898.1"}], "lineage": ["Eukaryota", "Fungi", "Fungi incertae sedis", "Microsporidia", "Pereziidae", "Ameson"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDL39898.1"}], "value": "Spore wall protein"}}]}, "references": [{"referenceNumber": 1, "citation": {"id": "CI-EHBMQ29N4SGSK", "citationType": "submission", "authors": ["Zhu Z.Q."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDL39898.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ114138", "properties": [{"key": "ProteinId", "value": "XDL39898.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MLNRINRTIFAKMNGPYQHAIFTDDFLEMEKNYKASRDSLEKIKTHIYFLMTYEFGGAGFKSIMENLEKISQSKMKSKNCFENLEKINRDLAHKISGENKEPVECIAENFMRINAEKRAFNGKLEELLAKIELLKAEVMNIDYLRNNLKDVQYKLEKCCRDNEDDFKRETFRSEFDQAMAKTRDEMEKFLDGNNFILIFKDLNSELKNYFKRSADVIKIN", "length": 220, "molWeight": 26070, "crc64": "80AB85A08E13A4D0", "md5": "07720C299564130CD2CF6AC25F1110AB"}, "extraAttributes": {"uniParcId": "UPI00388C0F81"}, "cluster_size": 1, "family": "Pereziidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P648", "uniProtkbId": "A0AAF0P648_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenuipotamon panxiense", "taxonId": 2841827, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69316.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69316.1"}], "value": "Neoverrucotoxin subunit beta"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69316.1"}], "value": "scaffold1720125"}}], "features": [{"type": "Coiled coil", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 53, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69316.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 136, "modifier": "EXACT"}, "end": {"value": 136, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69316.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69316.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69316.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69316.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69316.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR517369", "properties": [{"key": "ProteinId", "value": "WMS69316.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "PANTHER", "id": "PTHR32046:SF14", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR32046", "properties": [{"key": "EntryName", "value": "G DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "HKNFPYKYDLETRKTKKTVSELRQRYEEATKSKLTAENLVEEVNEEFNALQVKVLGMTHSVRKSLQRLQEIALRPNPLTTVQYIDILIESERSQAQPGWQARLEQLNNVKKEAEYMEMIADQGFDPFKQYAEKLEL", "length": 136, "molWeight": 16032, "crc64": "3BEFA706FB279E73", "md5": "D5CD39EA1B8F3C8903FBB9A7D9A1531C"}, "extraAttributes": {"countByFeatureType": {"Coiled coil": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B31FF5D"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6ND24", "uniProtkbId": "A0AAU6ND24_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59755.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59755.1"}], "value": "CSP6"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59755.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59755.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420115", "properties": [{"key": "ProteinId", "value": "WWA59755.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.2080.10", "properties": [{"key": "EntryName", "value": "Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005055", "properties": [{"key": "EntryName", "value": "A10/PebIII"}]}, {"database": "InterPro", "id": "IPR036682", "properties": [{"key": "EntryName", "value": "OS_D_A10/PebIII_sf"}]}, {"database": "Pfam", "id": "PF03392", "properties": [{"key": "EntryName", "value": "OS-D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF100910", "properties": [{"key": "EntryName", "value": "Chemosensory protein Csp2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "DCIMDKGNCGGYKTLVELSTKVVASKCAECSPNQKKIYDRVVEQLQEKFEPVYTALLKKAEAIKE", "length": 65, "molWeight": 7283, "crc64": "0C00AD46C6B62D4B", "md5": "F2EF4974C62D4A433168278AF1A1D26E"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D2E6B3"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DRE7", "uniProtkbId": "CRY2_TITOB", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Tityus obscurus", "commonName": "Amazonian scorpion", "synonyms": ["Tityus cambridgei"], "taxonId": 1221240, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Scorpiones", "Buthida", "Buthoidea", "Buthidae", "Tityus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "28918200"}], "value": "Cryptide Pep-2"}}}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}], "value": "Presents weak hemolytic activity at physiological concentrations (micromolar range), and weak lactate dehydrogenase (LDH) release from mast cells. Does not induce mast cell degranulation, and antimicrobial effects. In vivo, injection into mice induces very weak or no change in nociceptive sensibility, and very reduced or no edema formation. It also reduces mice locomotion, suggesting an increase in anxiety, but causes no alteration in rearing (standing on hind limbs)"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "28918200"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}], "features": [{"type": "Peptide", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "Cryptide Pep-2", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}], "featureId": "PRO_0000461737"}], "keywords": [{"id": "KW-0204", "category": "Biological process", "name": "Cytolysis"}, {"id": "KW-0903", "category": "Technical term", "name": "Direct protein sequencing"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}], "references": [{"referenceNumber": 1, "citation": {"id": "28918200", "citationType": "journal article", "authors": ["Dias N.B.", "de Souza B.M.", "Cocchi F.K.", "Chalkidis H.M.", "Dorce V.A.C.", "Palma M.S."], "citationCrossReferences": [{"database": "PubMed", "id": "28918200"}, {"database": "DOI", "id": "10.1016/j.jprot.2017.09.006"}], "title": "Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.", "publicationDate": "2018", "journal": "J. Proteomics", "firstPage": "70", "lastPage": "79", "volume": "170"}, "referencePositions": ["PROTEIN SEQUENCE", "IDENTIFICATION BY MASS SPECTROMETRY", "SUBCELLULAR LOCATION", "SYNTHESIS", "FUNCTION", "BIOASSAY"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0031640", "properties": [{"key": "GoTerm", "value": "P:killing of cells of another organism"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "GCDALLSGDHGGLLSANGC", "length": 19, "molWeight": 1760, "crc64": "54CD4A0248360504", "md5": "C2E5E1772FD606425FC9E63C4F4E8452"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1}, "countByFeatureType": {"Peptide": 1}, "uniParcId": "UPI00388C33BB"}, "cluster_size": 2, "family": "Buthidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF1C2X8", "uniProtkbId": "A0AAF1C2X8_9FABA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Stylosanthes guianensis subsp. guianensis", "taxonId": 198726, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD96597.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Fabales", "Fabaceae", "Papilionoideae", "50 kb inversion clade", "dalbergioids sensu lato", "Dalbergieae", "Pterocarpus clade", "Stylosanthes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD96597.1"}], "value": "BHLH32 protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD96597.1"}], "value": "bHLH32"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 207, "modifier": "EXACT"}, "end": {"value": 256, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00353"}]}, {"type": "Region", "location": {"start": {"value": 41, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 240, "modifier": "EXACT"}, "end": {"value": 274, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 49, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-72REDVEO80VI6", "citationType": "submission", "authors": ["Wang W.", "Zhang Z.S.", "Yang Y.L.", "Luo L.L.", "Jiang J.L."], "publicationDate": "NOV-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD96597.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR775508", "properties": [{"key": "ProteinId", "value": "WPD96597.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11393", "properties": [{"key": "EntryName", "value": "bHLH_AtbHLH_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "4.10.280.10", "properties": [{"key": "EntryName", "value": "Helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR044658", "properties": [{"key": "EntryName", "value": "bHLH92/bHLH041-like"}]}, {"database": "InterPro", "id": "IPR045239", "properties": [{"key": "EntryName", "value": "bHLH95_bHLH"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR055477", "properties": [{"key": "EntryName", "value": "DUF7049"}]}, {"database": "InterPro", "id": "IPR055478", "properties": [{"key": "EntryName", "value": "DUF7050"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "PANTHER", "id": "PTHR46665:SF1", "properties": [{"key": "EntryName", "value": "SPERMATOGENESIS- AND OOGENESIS-SPECIFIC BASIC HELIX-LOOP-HELIX-CONTAINING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46665", "properties": [{"key": "EntryName", "value": "TRANSCRIPTION FACTOR BHLH041-RELATED-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23132", "properties": [{"key": "EntryName", "value": "DUF7049"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23133", "properties": [{"key": "EntryName", "value": "DUF7050"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00010", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00353", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGCNKGEIELGFLNMSQAEIQTALSSLFPEDFSSAARQIVVDPQNNPPTSSSSSLRSLSTTTGGSPECSSLIFTVPPVAPPGTIVPNTASALLSHPSTATPHYMFPNQEIENETLMRVFLNAISPQHVQLQNQNLPYNITVVHPESSAFRRYRTEREAGAAEAGTSLRSRQSLMKRSLSFFRRINAMRVRERIQATRPSSNTQLHHMIAERRRREKLNDNFQALRALLPHGTKKDKASILTTAKETLSSLTAEIEKLRIRNQELESRFPETKESSTTATDQEIRKTILMVPPNERFHVQISDVPQSSSSEERMVDLHVAMRGQISHIDAVVRLLEFLKLAQNVSLVSMRTNTNDIGEGNNSINQLTFRLRILEGSEWDVSAFQEAVRRVVGELVQFQ", "length": 397, "molWeight": 44475, "crc64": "5F00AD37DCAA1284", "md5": "027E4F7A407B267123603171E91AA377"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Coiled coil": 1, "Compositional bias": 1}, "uniParcId": "UPI002B29DF49"}, "cluster_size": 1, "family": "Fabaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HCJ6", "uniProtkbId": "A0AA96HCJ6_9BILA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Phoronopsis harmeri", "taxonId": 490051, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25268.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Phoronida", "Phoronidae", "Phoronopsis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25268.1"}], "value": "Hypoxia-inducible factor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Domain", "location": {"start": {"value": 84, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 240, "modifier": "EXACT"}, "end": {"value": 291, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 28, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 591, "modifier": "EXACT"}, "end": {"value": 644, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 28, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 620, "modifier": "EXACT"}, "end": {"value": 629, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25268.1"}], "value": "Phoronop1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25268.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ355003", "properties": [{"key": "ProteinId", "value": "WNN25268.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005667", "properties": [{"key": "GoTerm", "value": "C:transcription regulator complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd11433", "properties": [{"key": "EntryName", "value": "bHLH-PAS_HIF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000005", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1 subunit alpha"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR001067", "properties": [{"key": "EntryName", "value": "Nuc_translocat"}]}, {"database": "InterPro", "id": "IPR001610", "properties": [{"key": "EntryName", "value": "PAC"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "InterPro", "id": "IPR013655", "properties": [{"key": "EntryName", "value": "PAS_fold_3"}]}, {"database": "NCBIfam", "id": "TIGR00229", "properties": [{"key": "EntryName", "value": "sensory_box"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23171", "properties": [{"key": "EntryName", "value": "bHLH_HIF1A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08447", "properties": [{"key": "EntryName", "value": "PAS_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00785", "properties": [{"key": "EntryName", "value": "NCTRNSLOCATR"}]}, {"database": "SMART", "id": "SM00353", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00086", "properties": [{"key": "EntryName", "value": "PAC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MPSMDKPKRRNSEKRKEKSRDAARNRRGKELEVFTDLISQLPLPNGDASQLDKASVLRLAISVLKLRRMLGDEDRGLNLSNGFNRKLDQQYLKALEGFLMVISSDGDITYLSENVSKYLGLAQVDLVGQNVFDYTHPCDHDEIREMVSAKHAPQPHEPTERTFFTRLKCTLTTKGRNVNLKSAAYKVLRCTGHIVHQEVKPNLGDSDTANSFLVMIAEPIPHPSNIEVPLGPCTFLSKHSLDMKFLYCDDRVYDLIGYSSSDLVGQSAYGYHHALDSTEVEKACKTLFSKGQSQIGQYRFLAKHGGYVWVITQATIIHHSKTQKPQCVVCVNFVISGVMEDGKVMSNIQQSRSPSSLPVRPPGIFREWNVDTKSDYGFTNGLTKIEELDPDEQSLYAPHSGEFLIPLDFSSFAQAGEPHDVLDDLLDTKTDTTYKNEPALYSCGNAKESVCASPEFTCPSFYMQPVDDVPPSHDAVSQQFTTDIFVDKDFELDSMDWDLRAPYIPMSCEEEIGIFQAGENLFTNACDFGESTKILGVTDTVFSSLPPSPPAKPPATTTCQAPTSLSYSILPTSSALSPSVASMMSCVSMAEPDSTVRGSPRGSPGMVSPGQQLLQKRKHGPEDPGDTRWKQPKYFDSSFSPPAMPPLTTIRKPSMANKNSVLMNLLLKNDDSIYGNRGKQIDKVTSALLPSRPGIARPSGQKWSILSPLQNREHGGGKMSDFVDLTRI", "length": 728, "molWeight": 80574, "crc64": "A846B43C36A5B39C", "md5": "21238EADADB0A64CC9E125D977D5D04F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 2, "Compositional bias": 2}, "uniParcId": "UPI002B2EA8C0"}, "cluster_size": 2, "family": "Phoronidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MNT6", "uniProtkbId": "A0AA96MNT6_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50050.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50050.1"}], "value": "Uncharacterized protein 8"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 109, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041664830"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50050.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460127", "properties": [{"key": "ProteinId", "value": "WNS50050.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MKPEGKILLALLLGLLMQGMLAASTMNEELLERVVFPCIYSDGQEFKDIDEQMSRYQAQLDEIALSVRVCDILAPDTKFALPECLPPGADKTSAGYVGRNSDGKVVVCG", "length": 109, "molWeight": 11852, "crc64": "5F4F818D39374CB7", "md5": "53DBC6AFDB3207B06E8EDB01797F5091"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B302DB2"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXF0", "uniProtkbId": "PHOAT_MYCS2", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)", "commonName": "Mycobacterium smegmatis", "taxonId": 246196, "lineage": ["Bacteria", "Bacillati", "Actinomycetota", "Actinomycetes", "Mycobacteriales", "Mycobacteriaceae", "Mycolicibacterium"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "25999286"}], "value": "Probable antitoxin PhoAT"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "25999286"}], "value": "phoAT"}, "orderedLocusNames": [{"value": "MSMEG_5247.5"}, {"value": "MSMEI_5108.5"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "25999286"}], "value": "Probable antitoxin component of a type II toxin-antitoxin (TA) system. The probable cognate antitoxin is PhoAT; the toxin gene can be expressed in the absence of the antitoxin gene in M.smegmatis strain mc(2)155 (PubMed:25999286)"}], "commentType": "FUNCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "25999286"}], "value": "Interacts with toxin PhoH2 (PubMed:25999286)"}], "commentType": "SUBUNIT"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "25999286"}], "value": "Part of the phoAT-phoH2 operon (PubMed:25999286)"}], "commentType": "INDUCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "25999286"}], "value": "Deletion of the phoAT-phoH2 genes has no visible growth phenotype (PubMed:25999286)"}], "commentType": "DISRUPTION PHENOTYPE"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the PhoAT antitoxin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 48, "modifier": "EXACT"}}, "description": "Probable antitoxin PhoAT", "featureId": "PRO_0000460850"}], "keywords": [{"id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"id": "KW-1277", "category": "Biological process", "name": "Toxin-antitoxin system"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-ET8TSAB7T4FCA", "citationType": "submission", "authors": ["Fleischmann R.D.", "Dodson R.J.", "Haft D.H.", "Merkel J.S.", "Nelson W.C.", "Fraser C.M."], "publicationDate": "OCT-2006", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"value": "ATCC 700084 / mc(2)155", "type": "STRAIN"}]}, {"referenceNumber": 2, "citation": {"id": "17295914", "citationType": "journal article", "authors": ["Deshayes C.", "Perrodou E.", "Gallien S.", "Euphrasie D.", "Schaeffer C.", "Van-Dorsselaer A.", "Poch O.", "Lecompte O.", "Reyrat J.-M."], "citationCrossReferences": [{"database": "PubMed", "id": "17295914"}, {"database": "DOI", "id": "10.1186/gb-2007-8-2-r20"}], "title": "Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?", "publicationDate": "2007", "journal": "Genome Biol.", "firstPage": "R20.1", "lastPage": "R20.9", "volume": "8"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"value": "ATCC 700084 / mc(2)155", "type": "STRAIN"}]}, {"referenceNumber": 3, "citation": {"id": "18955433", "citationType": "journal article", "authors": ["Gallien S.", "Perrodou E.", "Carapito C.", "Deshayes C.", "Reyrat J.-M.", "Van Dorsselaer A.", "Poch O.", "Schaeffer C.", "Lecompte O."], "citationCrossReferences": [{"database": "PubMed", "id": "18955433"}, {"database": "DOI", "id": "10.1101/gr.081901.108"}], "title": "Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol.", "publicationDate": "2009", "journal": "Genome Res.", "firstPage": "128", "lastPage": "135", "volume": "19"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"value": "ATCC 700084 / mc(2)155", "type": "STRAIN"}]}, {"referenceNumber": 4, "citation": {"id": "25999286", "citationType": "journal article", "authors": ["Andrews E.S.", "Arcus V.L."], "citationCrossReferences": [{"database": "PubMed", "id": "25999286"}, {"database": "DOI", "id": "10.1016/j.tube.2015.03.013"}], "title": "The mycobacterial PhoH2 proteins are type II toxin antitoxins coupled to RNA helicase domains.", "publicationDate": "2015", "journal": "Tuberculosis", "firstPage": "385", "lastPage": "394", "volume": "95"}, "referencePositions": ["IDENTIFICATION BY MASS SPECTROMETRY", "FUNCTION", "SUBUNIT", "OPERON STRUCTURE", "DISRUPTION PHENOTYPE"], "referenceComments": [{"value": "ATCC 700084 / mc(2)155", "type": "STRAIN"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "CP000480", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "CP001663", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP000000757", "properties": [{"key": "Component", "value": "Chromosome"}]}, {"database": "Proteomes", "id": "UP000006158", "properties": [{"key": "Component", "value": "Chromosome"}]}], "sequence": {"value": "MASDLLCCPGGTDRFDHERTGPGPAAVSTEQFVWGRMKSAVPLGAPRD", "length": 48, "molWeight": 5089, "crc64": "CD3DB9EC4BB6929A", "md5": "F2A4DC10910B57F393A2AD584AE310B8"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBUNIT": 1, "INDUCTION": 1, "DISRUPTION PHENOTYPE": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1}, "uniParcId": "UPI003390785F"}, "cluster_size": 1, "family": "Mycobacteriaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6SH69", "uniProtkbId": "A0AAU6SH69_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32412.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32412.1"}], "value": "Protein takeout-like protein"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00060902"}], "value": "Belongs to the TO family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 247, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043907533"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023108"}], "id": "KW-0090", "category": "Biological process", "name": "Biological rhythms"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B0NSJ4HC5RLL1", "citationType": "submission", "authors": ["S S.B.", "Negi N.", "Nagarjuna Reddy K.", "R G.G."], "title": "Takout-proteins of Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32412.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR247755", "properties": [{"key": "ProteinId", "value": "WZP32412.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007623", "properties": [{"key": "GoTerm", "value": "P:circadian rhythm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "3.15.10.30:FF:000001", "properties": [{"key": "EntryName", "value": "Takeout-like protein 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.15.10.30", "properties": [{"key": "EntryName", "value": "Haemolymph juvenile hormone binding protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR010562", "properties": [{"key": "EntryName", "value": "Haemolymph_juvenile_hormone-bd"}]}, {"database": "InterPro", "id": "IPR038606", "properties": [{"key": "EntryName", "value": "To_sf"}]}, {"database": "PANTHER", "id": "PTHR11008", "properties": [{"key": "EntryName", "value": "PROTEIN TAKEOUT-LIKE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11008:SF41", "properties": [{"key": "EntryName", "value": "RE70318P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF06585", "properties": [{"key": "EntryName", "value": "JHBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00700", "properties": [{"key": "EntryName", "value": "JHBP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFQRSSLIILCSLVALVYGRSLPSFIKPCKRNDPQLEKCLIELIEGIRSNLAKGIPEMRIPPLDPLHVPQVTLDQGSGSVNFQAKFKNIIASGAKNFNLTGVRLDFNVPSLSIDVGFPALRLDSDYNITGKVLVVPIKGNGKCQGNFTNVFASVKLLGKYDKRDGKTFLSVKERKINLKIGNLQIHFSNLFNGNKQLSESTNVFINENWRDILQEINPLVEDTIGEVMMQIIKGLLDLYSLEDLIPY", "length": 247, "molWeight": 27593, "crc64": "1650B0AC0FCF324D", "md5": "23D9A2ABB1060837336DB903C48787EC"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D3BF6F"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLS4", "uniProtkbId": "A0AAU0QLS4_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56480.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56480.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56480.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56480.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56480.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970373", "properties": [{"key": "ProteinId", "value": "WPO56480.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MILNTYISYICAFLVCTMDLFLCLMVFQIIGHIKILRHALRSFPTVKSQNDQLELHHVKETASCDLMFNKQENDIIKTKIKECVEHHLLIVNFADDISQFFGPLLAINYLNHLIILSLLLLECLQGV", "length": 127, "molWeight": 14660, "crc64": "EE1E11EA4F6E1A34", "md5": "DEE06BF0E6D32F6DFB73D4FBA3C5D478"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI003086668F"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1D6", "uniProtkbId": "A0AAU7P1D6_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30734.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30734.1"}], "value": "Low density lipoprotein receptor"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30734.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 129, "modifier": "EXACT"}, "end": {"value": 129, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30734.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30734.1"}], "id": "KW-0449", "category": "PTM", "name": "Lipoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30734.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30734.1"}], "value": "10", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30734.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892390", "properties": [{"key": "ProteinId", "value": "XBS30734.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "LIFQQACISLPTKNPSLETTCLMPYIWRQEPSMARGRCQIEPRCGSCLTCLCWLPQHCEAGNGLLHDEMRALYKGCYTWHHPEHFPVPGEDKRKGQPQLPYAAGRCSRSCAGRPMATVCRAGGGQLGAF", "length": 129, "molWeight": 14337, "crc64": "871CC4B7E18B68AE", "md5": "42C655689335BFD7659BE4B049380C17"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D3CD64"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LJ33", "uniProtkbId": "A0AAN0LJ33_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34103.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34103.1"}], "value": "Gamma-aminobutyric acid type B receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008991"}], "value": "Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 475, "modifier": "EXACT"}, "end": {"value": 502, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 514, "modifier": "EXACT"}, "end": {"value": 533, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 553, "modifier": "EXACT"}, "end": {"value": 572, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 651, "modifier": "EXACT"}, "end": {"value": 672, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 692, "modifier": "EXACT"}, "end": {"value": 709, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 715, "modifier": "EXACT"}, "end": {"value": 737, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 484, "modifier": "EXACT"}, "end": {"value": 759, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 3 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50259"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022553"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34103.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34103.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155029", "properties": [{"key": "ProteinId", "value": "WRW34103.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0038039", "properties": [{"key": "GoTerm", "value": "C:G protein-coupled receptor heterodimeric complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004965", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled GABA receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007214", "properties": [{"key": "GoTerm", "value": "P:gamma-aminobutyric acid signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd06366", "properties": [{"key": "EntryName", "value": "PBP1_GABAb_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.50.2300:FF:000072", "properties": [{"key": "EntryName", "value": "Gamma-aminobutyric acid type B receptor subunit 2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR002455", "properties": [{"key": "EntryName", "value": "GPCR3_GABA-B"}]}, {"database": "InterPro", "id": "IPR017978", "properties": [{"key": "EntryName", "value": "GPCR_3_C"}]}, {"database": "InterPro", "id": "IPR017979", "properties": [{"key": "EntryName", "value": "GPCR_3_CS"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "PANTHER", "id": "PTHR10519", "properties": [{"key": "EntryName", "value": "GABA-B RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10519:SF74", "properties": [{"key": "EntryName", "value": "GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00003", "properties": [{"key": "EntryName", "value": "7tm_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01177", "properties": [{"key": "EntryName", "value": "GABAB1RECPTR"}]}, {"database": "PRINTS", "id": "PR01176", "properties": [{"key": "EntryName", "value": "GABABRECEPTR"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00981", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F3_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50259", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F3_4"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIKKLIFSNLVLETNDTNSKRIKKINFNGFKSLNCLIKTLFFIFIFNPCLIQAKKPLYTAGFFPLSGEKADLGTGILPAVQLALDDVNENEVIPGYKLDLVGNDTECNAAVGMKIFFDMIFAAPKKYILFGDACPTVTDPIAKASRFFHLIQLSYADTHPMYTSDSYPNLFRVTPSQSAFNKARVALLKHFNWQRVGTIYKNSPRYSLPHSRLLTELDLTNIDIAYTQSLSDEVPFELIKIKEKDVRIILGNFGESWARKIFCQAYQHGIYGRKYQWIIAGEYSEFWWTKIDRGINCTRKELLAAIEGYIITDVLPLTSGNIITASGMTASEYEIRYNSLRGADYSKFHGYAYDGLWTIALAMQRVQKKLKTVYTNTTLEDFKYRDAFWSKLFRNALNETSFIGVTGNVSFFNNERRGSMILKQMQSGREVKIGEYHGTNDYLDLSVGKPISWGHNNVAPLDRTIKEIVSSRVNLTLFIVISIFAILGILLALVFLIMNIKYRKQRYIKMSSPYLNNLIIIGCILTYTSVILLGLDSRLLSEKNFPYICTARAWVLMTGFTLAFGSMFSKTYRVHAIFTNIKLNKKVIKDYKLFMVVGILVFIDVATLTTWQIVDPFYRQTNLGTPETTPENEDILIVPQMEYCQSKRMTIFLGSIYVYKGLLMAFGIFLAWETRHVSIPALNDSKYIGMSVYNVVIMCVIGAGLSVVLKDQQNAAFLIISIFIIFCSTATLCLVFVPKLIELKRNPNMDERRTRPTLKPFKKSRRESDEFELLNKIKNLTETNVRQRQKLKEKTYELEALMFRLRQINAEIAEDDAEIEQNKNQNIPELETKNLLNKQLMKPIDHNRLNTNQLKKQIFVVVGEESSSRSNDRETSFITLSASASFVSLNENCAIYAHCQQTNQNNKFQQSTLQQKFVSKKIEDTAYRCSNVNQIAKQLLIGNSDLTDDIIVLDQNLIQQHNSCPELHQMQQLKLLNDDQCNNNISERLMLSNTTNIKNNETDLDSLLSNCSNYSFKNEALEKDIENQLFNKNYNKERFKILNKKKELNINHRNNSHVNQSAKNKNKARCRMVKAISQIEPLSLIEKVREVRFAVQRSLKEAENEQIIKLDKVYKQKNKKKKKSFSLNDSNNQFSQKQFNLPSSINNLIKNDNLWNENYLNESKDLRKITYANENIFKNKSLDEDLPLSCDYLNNSSSSSSPSTAIGQNLINTKIKEKRKKKLKSKKQVKNSKIDNLKKNQSISICHQHSTFLQRRAVSLDTLNSQLYNCKNISKKKNCDDQDTEKKIEEEIKFNISTILSKPFNFTSTNLYDNIPKFPYSNLNNNRLTNSITTNSISTVAVCPKIDFFNKKLNTTNTLTQLTNTFSSSPSIKCDIVEYL", "length": 1380, "molWeight": 158502, "crc64": "19A42BE10D5DAC5E", "md5": "339BC0A723AA1CC59D65AA720474EBC3"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6, "Domain": 1}, "uniParcId": "UPI00325470DD"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1F0", "uniProtkbId": "A0AAU7P1F0_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30740.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30740.1"}], "value": "Apolipoprotein E"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30740.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 61, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30740.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30740.1"}], "value": "4", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30740.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892396", "properties": [{"key": "ProteinId", "value": "XBS30740.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "ARTWRTCAAAWCSTAARCRPCSARAPRSCGCASPPTCASCVSGSSAMPMTCRSAWQCTRPG", "length": 61, "molWeight": 6344, "crc64": "169D682F1DD929B4", "md5": "4CBF985AE4EFAB749B927DF1955444D2"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D2EE3C"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXX2", "uniProtkbId": "TXU8C_MEGOP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Megalopyge opercularis", "commonName": "Southern flannel moth", "synonyms": ["Phalaena opercularis"], "taxonId": 1113279, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Megalopygidae", "Megalopyge"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-megalopygitoxin(8)-Mo12"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-MPTX(8)-Mo12"}, {"evidences": [{"evidenceCode": "ECO:0000312", "source": "EMBL", "id": "WJJ70381.1"}], "value": "U-MPTX.8-12"}]}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "Aerolysin-like pore-forming toxin"}}, {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "Megalysin"}}], "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "value": "May function as a large pore-forming protein"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Secreted", "id": "SL-0243"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "value": "Target cell membrane", "id": "SL-0451"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Expressed by the venom apparatus"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Larvae"}], "commentType": "DEVELOPMENTAL STAGE"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "value": "Contains 2 disulfide bonds"}], "commentType": "PTM"}, {"commentType": "MASS SPECTROMETRY", "method": "MALDI", "molWeight": 29818.77, "molWeightError": 0.0, "note": "Monoisotopic mass.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the megalysin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 284, "modifier": "EXACT"}}, "description": "U-megalopygitoxin(8)-Mo12", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "featureId": "PRO_0000461530"}, {"type": "Modified residue", "location": {"start": {"value": 284, "modifier": "EXACT"}, "end": {"value": 284, "modifier": "EXACT"}}, "description": "Histidine amide", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}], "keywords": [{"id": "KW-0027", "category": "PTM", "name": "Amidation"}, {"id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-1052", "category": "Cellular component", "name": "Target cell membrane"}, {"id": "KW-1053", "category": "Cellular component", "name": "Target membrane"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "37428925", "citationType": "journal article", "authors": ["Walker A.A.", "Robinson S.D.", "Merritt D.J.", "Cardoso F.C.", "Goudarzi M.H.", "Mercedes R.S.", "Eagles D.A.", "Cooper P.", "Zdenek C.N.", "Fry B.G.", "Hall D.W.", "Vetter I.", "King G.F."], "citationCrossReferences": [{"database": "PubMed", "id": "37428925"}, {"database": "DOI", "id": "10.1073/pnas.2305871120"}], "title": "Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).", "publicationDate": "2023", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "e2305871120", "lastPage": "e2305871120", "volume": "120"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "MASS SPECTROMETRY", "PROBABLE AMIDATION AT HIS-284", "3D-STRUCTURE MODELING", "RECOMBINANT EXPRESSION", "SUBCELLULAR LOCATION", "TISSUE SPECIFICITY", "DEVELOPMENTAL STAGE"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP514863", "properties": [{"key": "ProteinId", "value": "WJJ70381.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0044218", "properties": [{"key": "GoTerm", "value": "C:other organism cell membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd20235", "properties": [{"key": "EntryName", "value": "PFM_spherulin-2a-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.170.15.10", "properties": [{"key": "EntryName", "value": "Proaerolysin, chain A, domain 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56973", "properties": [{"key": "EntryName", "value": "Aerolisin/ETX pore-forming domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNLQYLILSLLSTTVYGGFNLNFDSKGDALEKAAIDFTGEDVAVIKENERESFGITDGPLKDACGKVSGRRPDHVWLYKPTLWGDMYTMYKWPEVTRTLTPIAARVVGKEQKPMIVSSQVYRNRSNRTVKVNGKISQEVTNTVENKWSKTHGLSVTASMTYSFKVVEASMEIGYTSEWGQEETKSESVAVGQEMGFESELQPGESVEAVLSATKGSMIIDVTYRATLDGCCAINYNNGWKGHHYYCYPIGMVQDAGKLKKHVDVKETIKIGFYSDSHVIVRDKHGKK", "length": 287, "molWeight": 32066, "crc64": "70960EDBEB50110C", "md5": "6C6713A821F72A67C9864AF8A7BE55DB"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "DEVELOPMENTAL STAGE": 1, "PTM": 1, "MASS SPECTROMETRY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Modified residue": 1}, "uniParcId": "UPI00388C33AD"}, "cluster_size": 3, "family": "Megalopygidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0W2", "uniProtkbId": "A0AA96S0W2_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50042.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50042.1"}], "value": "Perlecan-like protein"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 96, "modifier": "EXACT"}, "end": {"value": 245, "modifier": "EXACT"}}, "description": "NIDO", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00539"}]}, {"type": "Domain", "location": {"start": {"value": 791, "modifier": "EXACT"}, "end": {"value": 866, "modifier": "EXACT"}}, "description": "Immunoglobulin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00409"}]}, {"type": "Domain", "location": {"start": {"value": 797, "modifier": "EXACT"}, "end": {"value": 854, "modifier": "EXACT"}}, "description": "Immunoglobulin subtype 2", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00408"}]}, {"type": "Domain", "location": {"start": {"value": 876, "modifier": "EXACT"}, "end": {"value": 975, "modifier": "EXACT"}}, "description": "Immunoglobulin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00409"}]}, {"type": "Domain", "location": {"start": {"value": 885, "modifier": "EXACT"}, "end": {"value": 963, "modifier": "EXACT"}}, "description": "Immunoglobulin subtype 2", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00408"}]}, {"type": "Domain", "location": {"start": {"value": 986, "modifier": "EXACT"}, "end": {"value": 1065, "modifier": "EXACT"}}, "description": "Immunoglobulin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00409"}]}, {"type": "Domain", "location": {"start": {"value": 992, "modifier": "EXACT"}, "end": {"value": 1053, "modifier": "EXACT"}}, "description": "Immunoglobulin subtype 2", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00408"}]}, {"type": "Domain", "location": {"start": {"value": 1077, "modifier": "EXACT"}, "end": {"value": 1153, "modifier": "EXACT"}}, "description": "Immunoglobulin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00409"}]}, {"type": "Domain", "location": {"start": {"value": 1083, "modifier": "EXACT"}, "end": {"value": 1141, "modifier": "EXACT"}}, "description": "Immunoglobulin subtype 2", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00408"}]}, {"type": "Domain", "location": {"start": {"value": 1168, "modifier": "EXACT"}, "end": {"value": 1251, "modifier": "EXACT"}}, "description": "Immunoglobulin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00409"}]}, {"type": "Domain", "location": {"start": {"value": 1174, "modifier": "EXACT"}, "end": {"value": 1235, "modifier": "EXACT"}}, "description": "Immunoglobulin subtype 2", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00408"}]}, {"type": "Domain", "location": {"start": {"value": 1259, "modifier": "EXACT"}, "end": {"value": 1339, "modifier": "EXACT"}}, "description": "Immunoglobulin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00409"}]}, {"type": "Domain", "location": {"start": {"value": 1265, "modifier": "EXACT"}, "end": {"value": 1324, "modifier": "EXACT"}}, "description": "Immunoglobulin subtype 2", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00408"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023319"}], "id": "KW-0393", "category": "Domain", "name": "Immunoglobulin domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50042.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460119", "properties": [{"key": "ProteinId", "value": "WNS50042.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0098632", "properties": [{"key": "GoTerm", "value": "F:cell-cell adhesion mediator activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007160", "properties": [{"key": "GoTerm", "value": "P:cell-matrix adhesion"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007156", "properties": [{"key": "GoTerm", "value": "P:homophilic cell adhesion via plasma membrane adhesion molecules"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00096", "properties": [{"key": "EntryName", "value": "Ig"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003006", "properties": [{"key": "EntryName", "value": "Ig/MHC_CS"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR003598", "properties": [{"key": "EntryName", "value": "Ig_sub2"}]}, {"database": "InterPro", "id": "IPR035234", "properties": [{"key": "EntryName", "value": "IgGFc-bd_N"}]}, {"database": "InterPro", "id": "IPR003886", "properties": [{"key": "EntryName", "value": "NIDO_dom"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "PANTHER", "id": "PTHR10075", "properties": [{"key": "EntryName", "value": "BASIGIN RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10075:SF100", "properties": [{"key": "EntryName", "value": "FASCICLIN-2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13895", "properties": [{"key": "EntryName", "value": "Ig_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13927", "properties": [{"key": "EntryName", "value": "Ig_3"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Pfam", "id": "PF17517", "properties": [{"key": "EntryName", "value": "IgGFc_binding"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF06119", "properties": [{"key": "EntryName", "value": "NIDO"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "SMART", "id": "SM00408", "properties": [{"key": "EntryName", "value": "IGc2"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "SMART", "id": "SM00539", "properties": [{"key": "EntryName", "value": "NIDO"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "PROSITE", "id": "PS00290", "properties": [{"key": "EntryName", "value": "IG_MHC"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAAEFVTGRMVSFSLSEPILVLFISFFVTLSVSAPYSRFVEYEGRGALVISTASRHLAFSREFFFSGQSFDSLMVHRDGSLELRDSETGSNVSLSVFKTSPSPTYGSVYHRFISTDENDDVGSELQDALTAMNVSFGSVLVDHSPHWAVIVTWHDMSMGNVNHNTFQAILLAMQESVASFVLYNYGSIQWPTRADQGECIAGYNTSFSTGYIIPGSQVGDSVGVMEVSNIDQPGMWAFRVDQHQTSLESEADSFYLAFAPPLNQRSRHKPYILVSTSEEGRVPITVDCPGIRLHQEATILKDSAYRLNFPSSLSSSYFQSNGGIRVTTTKGKKISVVAVSEVSPQYVTRYSVLHQRDLKRNYVYYVTTADDSQSTFTHLVIVGMYDRTRVKIHAPVLLRAGRRTVGANQVIELTIHEYRTLYVVARQDLSGMKIVSFSKPVAVFSGHACTQIPSRYTRCDSIMEQLPSTYDWGRKFVIPPMYGRSYSLLHVFAAADLTQFNLDCITKSGRQKERENVMIDSAGAHAVVQQSGSEICYLSANSSVLAVQFSISVAADTDSRQGGPAMLMIPSVQQFSKNAVVPALQASLEHSATIIVPEQYHHPSLIYINNETTLQNLTNTPLVYYNNYTISHYVYSVELQTAGVYHIHSEQPGARLGVIAVGHRESSSYAYMASIHSSGAKFESPLVKVIRGTDYAVCLTTTTQHSSTFWRDENGQVISTDSVLYANSSASSDFYCEVPALGFQPEFYYREKYTPSTLAISIQRGSTTGGGQNCDAEDCKTKCSFTVRVFPESATANIYSNITLYCTASVEEDIVSMKWSRAGSTVDEGPVMYLMQAGPQDAGTYTCTVTRTGGETGMASANVTILSYPPVITIHPTSVYTVLNEINTPIRLQCSAEYAGGLLWWEKLLSSNQHRRLQNWDILKSGRSTQNEILIDQSGDLLLLSPSRTSGGVYRCVAFNESGRAVSNPASVVIEGTQPLTIVMSPLNQTILINTTAVLRCLATGYGHIHYNWTRGNATVQGRAVDRGSELDVVDQDEDSEGEYTCVAYTEDEVVSSPQAFIRVLKPDKALAASVHPLNESVYEGRDAAFHCHGAHGQGDYTYLWMNDVDQAFGNTSTLVLSRVSMSHSGLYTCVVEDEMGMKTNATARLLVQDTKEPNITIPTIKNVTLSLVDRSRYAVFECDVGQDGMAYTWRKQEGPLPNRALGVNSSTLVLPVLALADAGKYQCSVTHLETRENATSAWAYLSLSVAPPTIKHHPANLTTALGGNVSLSCIAEGYGSLLYRWNRVGVGLVQTGSSPHLFLNNVTKSAEGQYKCSVTNQNGEASTSNFATITVRVSERVEVQNCNRTLLSSTLLSQNLRAPSFLKTDTLLLQGPIFSTSKQLSKDMKLLANSLVYVCHKGVQKSKGRSSTLQALTLGIAIEPDWVMTLSTICTGMCRNEQFDIVPLKQLSKYTNPAMKICKEIAGRGKAISVESDTSIHKSPANSSVLLLQLKRPLLTSYISKGSLLSRSQLLKLKSGNAVDLLGISSTESSTPPTPKRFKFRIRSKLPPSNAPLPAVTSQDSCSENLPESCSWFPGSPIVYQPPQSAKYALLGLAASQDGCSAAGIYESHISLSTDMEWIDETVV", "length": 1629, "molWeight": 178390, "crc64": "C87C10B06D3586CB", "md5": "8E392B1F9E55F1E7316BBD34605D4AF5"}, "extraAttributes": {"countByFeatureType": {"Domain": 13}, "uniParcId": "UPI002B2B485F"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LIZ6", "uniProtkbId": "A0AAN0LIZ6_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65895.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65895.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65895.1"}], "value": "UGT"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009995"}], "value": "Belongs to the UDP-glycosyltransferase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 318, "modifier": "EXACT"}, "end": {"value": 407, "modifier": "EXACT"}}, "description": "Glycosyl transferase family 28 C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF04101"}]}, {"type": "Coiled coil", "location": {"start": {"value": 836, "modifier": "EXACT"}, "end": {"value": 870, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65895.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145348", "properties": [{"key": "ProteinId", "value": "WRV65895.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR007235", "properties": [{"key": "EntryName", "value": "Glyco_trans_28_C"}]}, {"database": "InterPro", "id": "IPR050271", "properties": [{"key": "EntryName", "value": "UDP-glycosyltransferase"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48043", "properties": [{"key": "EntryName", "value": "EG:EG0003.4 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48043:SF145", "properties": [{"key": "EntryName", "value": "FI06409P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF04101", "properties": [{"key": "EntryName", "value": "Glyco_tran_28_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPEKKKIAFFSLLESGHLNLCSSVATTLLNKYFDKFEIYFFTDQKWADKLSEKDSRFKFEIYEYETKEQENFLEDMVNQLEPLLSLSHVEKMKILLKSFDYKDDFVYVDQEVSKLIKKLKPDYILCDLFCHMPALVENKIPYSFIISTNPLVLDIKDLPLLGLATDARDKKEIKATRLELKDSIDESKRNLEEIYRIRKVKIDDKYPINVPRSKHLSIYSYPKELDYFGDEIRQKYNLIQVDCPIVPSKIPTPFELPETFNEIPGKIIYVSLGSIFSCYYEKLQKLLDSLANLPYKYIVSKGPKGDKIKFPNKRFIGENFVDQLAVLQVVDMMISHGGNNTFTECFYFGVPALIFPVMGDQINNAKRIEETGFGSHISLMFYTENELKNKIKKILSNKALIEKTKKVGKRMRNDNSLEKTKKLIGINLLVLIGKVTEVRASQELILNQIAYKQSFDTLNSEKSFLSSSLESKKASFSMSNLNSLQVGLVTCTENDSFFELPFVKKQNILPKNYETILETLKHSLVLSESIQNKPESVNAERIFDLKKSLNVSINDQLNSENKLNIETVNSKKVKPFLEGLQHNLDVSQKQVNESVQNVQKEKPYLQRANSSFIEQDSITVGFNTVQDNQTIKDYDLLIKPKTIEQDFVLQKSANVLEIFSNSKELEVESSKTDSQRINQQIIEKNCIQIKENIPLNVEKALEKNYELKLNNAIKNLQTHHGVLSQEQISMNEAELKYKPKLKKKSIAMPKIITQEAILVSSINLDDKEEILKDKKSKTKTAKKTIKPQKALQVSKTKFLDSENIIEQGKIEKVSLNQSLPSIDAIQVNQIIANNSLQELEIEKQSFKKVIVDLQENLAFTNTDNLALEKENKFFKKNEKIKYASKDLMKQKSISVKQLYADENLLNFGSSKIKKLKAKRDLSESKCKSLNITSHSTNDVLNKLTEKNFSKEKAKLILSDFENLNVNEKILLDKESELLSLKTEKVKPKKSKVLNRTASFSVERLDVLEKERVFMNDTFQFKKANIDFVTKKAASKSDILQVENENFYNFPKLQHSFVESSIENLQSLNVNSVLAVENEESFKKHSIKKKKLNYKIDALNLISADSTCKQSQFLVSVNEDSKANLQLESTLPLNVFQSKVENQVTKLNLKPEAIKQANPSLQNLNISLLVQKPEVQIKEGVLEINEDKEAKVKGKIIGQSSLNINFYKPFNTFEEFKPKTDNLACSKISLVEKNSYETHETVENEN", "length": 1245, "molWeight": 142921, "crc64": "304D689AB7CA9B2F", "md5": "43DCA6D0D6F2C6D17314F879D64D5464"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Coiled coil": 1}, "uniParcId": "UPI0032472651"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEB8", "uniProtkbId": "A0AB38ZEB8_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71754.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71754.1"}], "value": "Venom S1 protease with CUB domain 6"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 338, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044197720"}, {"type": "Domain", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 132, "modifier": "EXACT"}}, "description": "CUB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS01180"}]}, {"type": "Region", "location": {"start": {"value": 258, "modifier": "EXACT"}, "end": {"value": 277, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 258, "modifier": "EXACT"}, "end": {"value": 269, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 78, "modifier": "EXACT"}, "end": {"value": 95, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 338, "modifier": "EXACT"}, "end": {"value": 338, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71754.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71754.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71754.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71754.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510829", "properties": [{"key": "ProteinId", "value": "WXH71754.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007340", "properties": [{"key": "GoTerm", "value": "P:acrosome reaction"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00041", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.290", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000859", "properties": [{"key": "EntryName", "value": "CUB_dom"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR018114", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}]}, {"database": "PANTHER", "id": "PTHR24252:SF8", "properties": [{"key": "EntryName", "value": "ACROSIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24252", "properties": [{"key": "EntryName", "value": "ACROSIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00431", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01180", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00134", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLTLVCCAILLAALSTSAIDEESIIKLKRGSVFTDLKTPDYPYGSDVDEPIEWIIQTESESKLKIHCEDFRLTDSEDCLSAYLKIEDNGNVKTYCSEVHQLTYTSVSSRIVINLGGNGGQAAISCIAKSIELPEPDFIDIVEDKAHHLEISSGPIPFFDKIWHFQTKEHLKIQFRCFINLLQTENCHKEVLKVYIGIGEQIYCGAREEVFTSENHLASIRLELGRTGIGKLFCSVQATKGAELLEPSKDEIDTVRSLRVNEEDSSEHGGKPGPKGTTCNCGWANKPRSRIIRGKEASPNEYPWMVALKAYFGEAHIDCGGSIITHRHVLTAAHCLLNI", "length": 338, "molWeight": 37584, "crc64": "25B9CE15EBCE9149", "md5": "D25BBDFB7DDDFC0F8DF89EEAB36FEB68"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 1, "Disulfide bond": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388BDE2C"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEN9", "uniProtkbId": "A0AB38ZEN9_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02731.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02731.1"}], "value": "Heteropteran venom family 8 protein 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044342570"}, {"type": "Region", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 88, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02731.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517481", "properties": [{"key": "ProteinId", "value": "WXI02731.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MNAVVIFLLQFLIQVVVSTSVSTSTINGQTITYLDNKKVDLSKAEILEKTDLCTVYKPAENKSCTLVKCVHGATSVKCGGSSSVSSSGNMTPEEVDDFNRLSNKY", "length": 105, "molWeight": 11342, "crc64": "B1CDE8C5D076E168", "md5": "963F8C0C5DB2373ED22907C99DB3C2B3"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI00388BC681"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QJZ1", "uniProtkbId": "A0AAU0QJZ1_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56487.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56487.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 41, "modifier": "EXACT"}, "end": {"value": 59, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 142, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 183, "modifier": "EXACT"}, "end": {"value": 209, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 284, "modifier": "EXACT"}, "end": {"value": 303, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56487.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56487.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56487.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56487.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970380", "properties": [{"key": "ProteinId", "value": "WPO56487.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "YDQLDGTFRQSLDYSLGFFRFLGIYFFNISHLSLVQKYSRFIVFIIGYVFLFGCIFYSAKYDEQNIQGLAIRIPALLLVLMSVPKQYLLFRMRARDRISGVMQQINDEWPSEKELKDLKKKNEIAKWQTHCSMFFKTIMRFVMAYTISFNIKSFIAAWQKLYITPDMVMRMPSSYGLPKPNTPFILFLGMFSAQAAAGLSLEVICYFALNALIGVNVMNIKALFIILQIDLENSINDENGLVKPVDTSNTDNVSSYRNIRIIIKRHQKILSICNEMNAIFSPTIFVDVTLSAIVMGFYGFVLVTEVSEVTCYKLQFSKRHDIQY", "length": 324, "molWeight": 37478, "crc64": "1CD8BFD64002F8B9", "md5": "37EF74CEB614A5554ADC4579D259EDDC"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 6, "Non-terminal residue": 1}, "uniParcId": "UPI00308B8B35"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7BND7", "uniProtkbId": "A0AAU7BND7_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33919.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33919.1"}], "value": "Glycosyltransferase"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33919.1"}], "value": "ABO"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001936"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004606"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004606"}], "value": "Single-pass type II membrane protein", "id": "SL-9906"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010413"}], "value": "Belongs to the glycosyltransferase 6 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 3, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:67138"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR605076-2"}], "ligand": {"name": "UDP-N-acetyl-alpha-D-galactosamine", "id": "ChEBI:CHEBI:67138"}}, {"type": "Binding site", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 6, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:67138"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR605076-2"}], "ligand": {"name": "UDP-N-acetyl-alpha-D-galactosamine", "id": "ChEBI:CHEBI:67138"}}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33919.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 60, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33919.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022968"}], "id": "KW-0735", "category": "Domain", "name": "Signal-anchor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022968"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-D2446FVSI6Q1B", "citationType": "submission", "authors": ["Zhong J.", "Gao Y.M.", "Mo C.P.", "Zhang Y.", "Li L.B.", "Wei S.T.", "Li T.Y."], "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33919.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP834549", "properties": [{"key": "ProteinId", "value": "XBG33919.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "PeptideAtlas", "id": "A0AAU7BND7", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.90.550.10", "properties": [{"key": "EntryName", "value": "Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005076", "properties": [{"key": "EntryName", "value": "Glyco_trans_6"}]}, {"database": "InterPro", "id": "IPR029044", "properties": [{"key": "EntryName", "value": "Nucleotide-diphossugar_trans"}]}, {"database": "PANTHER", "id": "PTHR10462", "properties": [{"key": "EntryName", "value": "GLYCOSYLTRANSFERASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10462:SF29", "properties": [{"key": "EntryName", "value": "HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03414", "properties": [{"key": "EntryName", "value": "Glyco_transf_6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53448", "properties": [{"key": "EntryName", "value": "Nucleotide-diphospho-sugar transferases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "FAIKKYVAFLKLFLETAEKHFMVGHRVHYCVFTDQPAAVPRVTLGTGRQLSVLEVRAYKR", "length": 60, "molWeight": 6938, "crc64": "500FEB87547D019F", "md5": "A94121237BA5450E3041E1E516F95FD8"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 2, "Non-terminal residue": 2}, "uniParcId": "UPI0035D381F3"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MLU7", "uniProtkbId": "A0AA96MLU7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50082.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50082.1"}], "value": "Fibronectin-like protein"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 28, "modifier": "EXACT"}, "end": {"value": 682, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041635283"}, {"type": "Domain", "location": {"start": {"value": 31, "modifier": "EXACT"}, "end": {"value": 124, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 129, "modifier": "EXACT"}, "end": {"value": 220, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 221, "modifier": "EXACT"}, "end": {"value": 318, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Region", "location": {"start": {"value": 461, "modifier": "EXACT"}, "end": {"value": 657, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 461, "modifier": "EXACT"}, "end": {"value": 614, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 643, "modifier": "EXACT"}, "end": {"value": 657, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50082.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460159", "properties": [{"key": "ProteinId", "value": "WNS50082.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd00063", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR050991", "properties": [{"key": "EntryName", "value": "ECM_Regulatory_Proteins"}]}, {"database": "InterPro", "id": "IPR003961", "properties": [{"key": "EntryName", "value": "FN3_dom"}]}, {"database": "InterPro", "id": "IPR036116", "properties": [{"key": "EntryName", "value": "FN3_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "PANTHER", "id": "PTHR46708:SF2", "properties": [{"key": "EntryName", "value": "FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46708", "properties": [{"key": "EntryName", "value": "TENASCIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00041", "properties": [{"key": "EntryName", "value": "fn3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00060", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SUPFAM", "id": "SSF49265", "properties": [{"key": "EntryName", "value": "Fibronectin type III"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50853", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "3"}]}], "sequence": {"value": "MDSCCSLQFVFLSAVVGAIFLGRGVEGTVQPPTGLTVNGYTRYVLYQFNTSPTEGCMHEVLAVAKREGIPNHGPTKLERLSPSVRTFQTLSGLYPGTDYTLQVTAVCPGNQSASVAANFTTLPEVPNGPPQRLMVSEATGTTATLSWEEPAPVHVNDKGGITAYILEANSSTAVSIRKKTYTLENLSPGSVYSVMVYAENSVGRSSQDDAAALTFTTSSEAPGAPVITGLLPRFYLVAISWDLPTPRTGAVTGYHMQYSIDGRLPYDRVFEGTTFTRYHIVHAPTDSVGLTHSVKVRAQTGGGYGPFCAPVTFVYRQIVVPTIRPLGCDKVSIAYTVHPLPACSHPTLKDRVTSVVFSYNVSTNATENVKLFQEVSLHGGEGQLVVSGLIPGNRYHFTAGLVATAGSSASLPMDMSRDMVVVLPGDGPCLETNECLAREFFTPSNSCSLVPSEHCDLTSQTTQTTTDTQPTATQTFSQTTTQASSQTTTEASSQTTTQTSSQTTTQTSSQTTTQTSSQTTTQASSQTTTQASSQTTTQASSQTTTEASSQTTTEASSQTTTEASSQTTTQASSQTTTRASSQTVASSQMPTTPASASPTTRVVPTPTSATTPPTDAIGNVGNQPSATPTSPIGPPIGPPTGSNQGNTSVSGPQESSSAKSCKETLVALVISVFFSAILQTLY", "length": 682, "molWeight": 71582, "crc64": "B1B2476AED9E5B67", "md5": "FC7A61302F2234E0FB289E5D989C6F69"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 3, "Region": 1, "Compositional bias": 2}, "uniParcId": "UPI002B2C5C29"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU96", "uniProtkbId": "A0AAT9UU96_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41713.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41713.1"}], "value": "Cytochrome P450 4461Q1"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003690"}], "value": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides"}], "commentType": "FUNCTION"}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 436, "modifier": "EXACT"}, "end": {"value": 436, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41713.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117273", "properties": [{"key": "ProteinId", "value": "WIM41713.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002403", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-IV"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00465", "properties": [{"key": "EntryName", "value": "EP450IV"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIITITFASLVAVFFVRYIYKLKHARLYRLLEQFPSYPTYPLIGNLHLLFGSPNSIMQKLDDIARPHNNLVFWWGPIPALMLTKYRDISTISNQSNDRNIQGFTYPWSDVGILTARGNEWKTSKKMLTPAFSTEMLTKYVNVFNKKASDLARKFEHVADTEEIIDVFHIVSYINCDASTENTLGVSIQNCGKGQQFYEAISECIKDGVERLFNLWLHPTFMYLAYLKITGKIKFVNHLHDFSTKIIKNILNDFRQRPHESNNDNSSESMVHLLLKKNLQEVNMTETRIRDEMIQVLLASMETSTVTLSFLMLMLAIHQNIQQKVYEEVEQFPNDESLTFTQLTNQLQYLEQCIKETIRLYAHGTIFFRYTNKEHVLDDNKIVPGGIFIIALTRFAYQDAELYANPQKWDPEHFSEKTSTNRPKGSDLLFGYGARSCIGSKYAMMSIKTQIVYILRKYHLSTNIKELKEDDLGVDLMIRSKPGFPIKFIKRQKIVQNHKINHN", "length": 502, "molWeight": 58363, "crc64": "46E8162FF94F70E3", "md5": "8513AF68F91A30311EB698DC595BDC1F"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D35D4C"}, "cluster_size": 3, "family": "Pseudococcidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXZ4", "uniProtkbId": "TX1A_XYLAR", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Xylocopa aruana", "commonName": "Great carpenter bee", "taxonId": 135674, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Hymenoptera", "Apocrita", "Aculeata", "Apoidea", "Anthophila", "Apidae", "Xylocopa", "Koptortosoma"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36550366"}, {"evidenceCode": "ECO:0000305"}], "value": "Xylotoxin(1)-Xa1a"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36550366"}], "value": "XYTX(1)-Xa1a"}, {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36550366"}], "value": "XYTX1-Xa1a"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36550366"}], "value": "Cytotoxin that provokes cell lysis. Induces leak currents in cell membranes in the same way as melittin, suggesting a membrane disrupting mode of action. Also activates DRG neurons. DRG activation and cell lysis is potentiated by phospholipase A2 (PA2). In vivo, intraplantar injection in mice causes spontaneous pain behaviors and paw swelling, which are also potentiated by PA2 coinjection"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36550366"}], "value": "Secreted", "id": "SL-0243"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Target cell membrane", "id": "SL-0451"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "36550366"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Propeptide", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "36550366"}], "featureId": "PRO_0000461566"}, {"type": "Peptide", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 50, "modifier": "EXACT"}}, "description": "Xylotoxin(1)-Xa1a", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36550366"}], "featureId": "PRO_0000461567"}, {"type": "Modified residue", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 50, "modifier": "EXACT"}}, "description": "Proline amide", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36550366"}]}], "keywords": [{"id": "KW-0027", "category": "PTM", "name": "Amidation"}, {"id": "KW-0903", "category": "Technical term", "name": "Direct protein sequencing"}, {"id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-1052", "category": "Cellular component", "name": "Target cell membrane"}, {"id": "KW-1053", "category": "Cellular component", "name": "Target membrane"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "36550366", "citationType": "journal article", "authors": ["Shi N.", "Szanto T.G.", "He J.", "Schroeder C.I.", "Walker A.A.", "Deuis J.R.", "Vetter I.", "Panyi G.", "King G.F.", "Robinson S.D."], "citationCrossReferences": [{"database": "PubMed", "id": "36550366"}, {"database": "DOI", "id": "10.1038/s41598-022-26867-8"}], "title": "Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana.", "publicationDate": "2022", "journal": "Sci. Rep.", "firstPage": "22168", "lastPage": "22168", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "PROTEIN SEQUENCE OF 34-50", "IDENTIFICATION BY MASS SPECTROMETRY", "SUBCELLULAR LOCATION", "AMIDATION AT PRO-50", "SYNTHESIS OF 34-50", "FUNCTION", "BIOASSAY"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}, {"value": "Venom gland", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON586842", "properties": [{"key": "ProteinId", "value": "UTO68649.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0044218", "properties": [{"key": "GoTerm", "value": "C:other organism cell membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MKFLFSVLVLFIVAFVCLSNAEPEPDPEADPEAGFLSILKKLPLILKHLPGK", "length": 52, "molWeight": 5737, "crc64": "B2AE4E798FA87064", "md5": "2A5ABF0AB2AB74C5B7F4BFB0EAF4BB64"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1}, "countByFeatureType": {"Signal": 1, "Propeptide": 1, "Peptide": 1, "Modified residue": 1}, "uniParcId": "UPI002206F8FD"}, "cluster_size": 1, "family": "Apidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96K9Y7", "uniProtkbId": "A0AA96K9Y7_9MOLL", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Epimenia babai", "taxonId": 231999, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25248.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Aplacophora", "Solenogastres", "Cavibelonia", "Epimeniidae", "Epimenia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25248.1"}], "value": "Hypoxia-inducible factor 1"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 84, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 237, "modifier": "EXACT"}, "end": {"value": 283, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 371, "modifier": "EXACT"}, "end": {"value": 371, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25248.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25248.1"}], "value": "Epim1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25248.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354983", "properties": [{"key": "ProteinId", "value": "WNN25248.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "InterPro", "id": "IPR013655", "properties": [{"key": "EntryName", "value": "PAS_fold_3"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08447", "properties": [{"key": "EntryName", "value": "PAS_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MDSVKAKAKRRSSEKRRLKAKESAQIRRTAETELFQMMISLLPLKLTAIKFNYTQAIRISIAIIHHFEIKRNKFETACSSNIKSEIDSPSIHDALHGFFIILSSNGNVIFVTDNISKHIGISQQELLGSSLYDYLHHCDIKEVRSILTPKSSSSSQNGAPCAVHFLCRVKCTLTHRGTVTSFKSAPHRVIQFTGRHLYIPRGVYLMALCEPVPHPTNIEVPLGRSTFLSRHDPCMVFTYCDDRMSELVGFTSEDVLGHSVYEYHHACDTGIIQHAHKDLFAKGQCISNEYRFLVKHGGYVQMMSQSTVIYHDLTNEPHSVISVNFVLSGVHCRDLILSHIQVPRELLSTQQLDINPMVNHNAEDKQKRKKY", "length": 371, "molWeight": 42128, "crc64": "32EC98A0F97B6618", "md5": "42DF551213E1AB71C4864FAD90B3FA59"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 2, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI002B299D2E"}, "cluster_size": 2, "family": "Epimeniidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA86J3I1", "uniProtkbId": "A0AA86J3I1_PHYPO", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Physarum polycephalum", "commonName": "Many-headed slime mold", "synonyms": ["Badhamia polycephala"], "taxonId": 5791, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96134.1"}], "lineage": ["Eukaryota", "Amoebozoa", "Evosea", "Eumycetozoa", "Myxogastria", "Myxogastromycetidae", "Physariida", "Physaraceae", "Physarum"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96134.1"}], "value": "Trehalose-6-phosphate phosphorylase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96134.1"}], "value": "T6pp"}}], "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:32675"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:15903"}, {"database": "ChEBI", "id": "CHEBI:16551"}, {"database": "ChEBI", "id": "CHEBI:17925"}], "ecNumber": "3.2.1.28", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001576"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006768"}], "value": "Belongs to the glycosyl hydrolase 65 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 823, "modifier": "EXACT"}, "end": {"value": 880, "modifier": "EXACT"}}, "description": "FYVE-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50178"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00091"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8FNH18LGM7QJ2", "citationType": "submission", "authors": ["Minami Y.", "Morita R.", "Okano S.", "Ishii K.", "Furukawa A.", "Teramoto C."], "title": "Analysis of trehalose synthesis pathway from Physarum polycephalum.", "publicationDate": "FEB-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96134.1"}], "value": "Ai35Xdp246", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96134.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC757378", "properties": [{"key": "ProteinId", "value": "BDX96134.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004555", "properties": [{"key": "GoTerm", "value": "F:alpha,alpha-trehalase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0030246", "properties": [{"key": "GoTerm", "value": "F:carbohydrate binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00065", "properties": [{"key": "EntryName", "value": "FYVE_like_SF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.50.10.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.70.98.40", "properties": [{"key": "EntryName", "value": "Glycoside hydrolase, family 65, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.420.10", "properties": [{"key": "EntryName", "value": "Maltose phosphorylase, domain 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.40.10", "properties": [{"key": "EntryName", "value": "Zinc/RING finger domain, C3HC4 (zinc finger)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008928", "properties": [{"key": "EntryName", "value": "6-hairpin_glycosidase_sf"}]}, {"database": "InterPro", "id": "IPR012341", "properties": [{"key": "EntryName", "value": "6hp_glycosidase-like_sf"}]}, {"database": "InterPro", "id": "IPR011013", "properties": [{"key": "EntryName", "value": "Gal_mutarotase_sf_dom"}]}, {"database": "InterPro", "id": "IPR037018", "properties": [{"key": "EntryName", "value": "GH65_N"}]}, {"database": "InterPro", "id": "IPR005194", "properties": [{"key": "EntryName", "value": "Glyco_hydro_65_C"}]}, {"database": "InterPro", "id": "IPR005195", "properties": [{"key": "EntryName", "value": "Glyco_hydro_65_M"}]}, {"database": "InterPro", "id": "IPR005196", "properties": [{"key": "EntryName", "value": "Glyco_hydro_65_N"}]}, {"database": "InterPro", "id": "IPR017455", "properties": [{"key": "EntryName", "value": "Znf_FYVE-rel"}]}, {"database": "InterPro", "id": "IPR013083", "properties": [{"key": "EntryName", "value": "Znf_RING/FYVE/PHD"}]}, {"database": "PANTHER", "id": "PTHR11051", "properties": [{"key": "EntryName", "value": "GLYCOSYL HYDROLASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11051:SF8", "properties": [{"key": "EntryName", "value": "PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03633", "properties": [{"key": "EntryName", "value": "Glyco_hydro_65C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03632", "properties": [{"key": "EntryName", "value": "Glyco_hydro_65m"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03636", "properties": [{"key": "EntryName", "value": "Glyco_hydro_65N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF74650", "properties": [{"key": "EntryName", "value": "Galactose mutarotase-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48208", "properties": [{"key": "EntryName", "value": "Six-hairpin glycosidases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50178", "properties": [{"key": "EntryName", "value": "ZF_FYVE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSKDNDPSWHLVYDSFDPKQVSLREALCVLGNGLYATRGCSEESCADGIHYPATYLAGAYDRLTAKVEDKDVSNESLVNFPNWLPITFRCGPNEEWFKINEKGTNILKYRLDLDMYNGILRREMLVEDDSRREFEITSTRFINLHTQNPHAAGLQYSVKPINWSGEMQIRSSLDGSVENTGIKRYEGLGSKHLRVENLGEVEPHGIYLEVKTVQSNISFCQAARTTVQVGKKKITKAHVEKEKERIHMIYTFHIEKGQTAVAEKLIAMYFNSAKGILDAKEACLHQIKWLPSYSELENIHKEAWGLAWFNWDIVLKYSDDNSADSLQQVVRLHIFHMIQTVSLNTIGYDVSVPARGLHGESYRGHIFWDELFIIPFYTLHVPEVAKTLLRYRYYRLDRARHLAAEAGYKGAMFPWQSGSDGREESQTIHYNPLDKTWGPDNSSLQRHVNIAIAVNIVRYFDTVKDGFFMEKYGAEILFEICRFFASLCTFNHASGRYEIKGVMGPDEFHERLPRSENQGLDNNTYTNVMVVWLLQKALDMLRGSAMREPLKERIVHTLGIKPQDMELWEDITKKMTIVFHKDGQIWSQFQGYEDLRDLDFEAYRKKNDNNIERMDRILKAAKDSPDNYKVSKQPDVCMLFYLLTTKEIEGIFRGLGYPFKESMIQANIEYYLQRTTHGSTLSKMIFSTILQPYDKEQAWGMFMESVRSDIDDTQGGTTGEGIHLALMSGSLFAVIRMYAGVDTSNRILRINPEMPKALKKIKFFIQFRGVLVDIVVTHSSVKVSSSWNFFPVIVQGVTMLATSKSFRKRIKDQPNTKECPKETNCAECSASIKVGNNSICRSCGRDMCDNCLKRNIGWYNVLIPEDPHIKVCKDCADGIDQNDNVERHPHHKMEGLKRDTNNLTKSELVSE", "length": 911, "molWeight": 104622, "crc64": "9EC8D7964E93A322", "md5": "4D9FCD50D2079EE69824D49215EAEDCC"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI002B2A0F4F"}, "cluster_size": 1, "family": "Physaraceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LJ47", "uniProtkbId": "A0AAN0LJ47_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34085.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34085.1"}], "value": "Glutamate receptor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 642, "modifier": "EXACT"}, "end": {"value": 663, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 684, "modifier": "EXACT"}, "end": {"value": 702, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 722, "modifier": "EXACT"}, "end": {"value": 743, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 904, "modifier": "EXACT"}, "end": {"value": 926, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 507, "modifier": "EXACT"}, "end": {"value": 885, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00079"}]}, {"type": "Domain", "location": {"start": {"value": 517, "modifier": "EXACT"}, "end": {"value": 586, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor L-glutamate and glycine-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00918"}]}, {"type": "Binding site", "location": {"start": {"value": 595, "modifier": "EXACT"}, "end": {"value": 595, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 597, "modifier": "EXACT"}, "end": {"value": 597, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 602, "modifier": "EXACT"}, "end": {"value": 602, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 771, "modifier": "EXACT"}, "end": {"value": 771, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 772, "modifier": "EXACT"}, "end": {"value": 772, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 821, "modifier": "EXACT"}, "end": {"value": 821, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Site", "location": {"start": {"value": 750, "modifier": "EXACT"}, "end": {"value": 750, "modifier": "EXACT"}}, "description": "Crucial to convey clamshell closure to channel opening", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Site", "location": {"start": {"value": 777, "modifier": "EXACT"}, "end": {"value": 777, "modifier": "EXACT"}}, "description": "Interaction with the cone snail toxin Con-ikot-ikot", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 417, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 834, "modifier": "EXACT"}, "end": {"value": 889, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34085.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34085.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155011", "properties": [{"key": "ProteinId", "value": "WRW34085.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0022824", "properties": [{"key": "GoTerm", "value": "F:transmitter-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0007166", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "1.10.287.70:FF:000067", "properties": [{"key": "EntryName", "value": "glutamate receptor 2 isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000060", "properties": [{"key": "EntryName", "value": "Glutamate receptor ionotropic, kainate 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000001", "properties": [{"key": "EntryName", "value": "Glutamate receptor ionotropic, kainate 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR001508", "properties": [{"key": "EntryName", "value": "Iono_Glu_rcpt_met"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00177", "properties": [{"key": "EntryName", "value": "NMDARECEPTOR"}]}, {"database": "SMART", "id": "SM00918", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81324", "properties": [{"key": "EntryName", "value": "Voltage-gated potassium channels"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPAQFTLQQIPVGAIFMDNDIESKNSFYLAVNLYNEKNNSKFKIEPIVDLIPKNEPYIFTNHLCRQLKAGIFALITPISGDSYETLISYSNTFQLPTIHAGYSIHNTPLLTENFFVQMPKFTVFLEPHYLTAIYQLADMYNWDNVIYLYDSNQGLNKLQYLLNLLNSTRYENFLDYDLTKNTANQFVEKRELRLTAMKKITSGIEGFKFIKKFELADKESIKHVIIDCEFDVVKELIVNHVNDIYMGRRNYHFLLSSLVIDNIIRNGHKTPELFAVNITGIRLLDLDFLNKTKYSLADSPVKIIETNGINKLSKKVIPRKLNSKEINSLITILESWVKNNTALDHSLTNSQKNSFNSKPTNVKDITVKSSLMFDSVFLLAKALDRIFIDKPLVLNGNFWRDDYYINNKSDNFKGIDCSKQYPFAHWQHGRLITDYIKSTRIQGLTGEISFDKNTGIRNNYTLKAYQTLLNNRLVNMGSWSSEANQLISIQKSYQRNFQIPQIERNITYLVTSILEEPFLFLKNESNNGKKLEGNDRFEGYCKDLADLIAEKMGINYELRLVKDKKYGGIDKTSDAGWNGMVGELIKKEADLAIAPLTITSARERVIDFTKPFLSLGISIMIKKPAKKNPDIFSFMNPLSADIWYFILLSYLAVSSIIFIVSRISPNECRIEEEQNSNGDRVTKIVNEFSFCNSLWFALAALFQQGVDICPRSYAGRIAGSVWWFFTLIIISSYTANLAAFLTVERMVTPINSADDLAKQTEVEYGVLKDSSTQEFFRNSKIQVYSRMWDFMVARSHVFVETYSEGIKRVRESKGKYAFLMESTQNDYINERQPCDTMKVGRNLDAKGFGIATPLNSPLSHSLNIIVLALTESGDLTRLESKWWFDRSECKNSDSKENRKKSLTLYNVAGCFYILIAGLILALIASLCELIKNHCRTCKKK", "length": 940, "molWeight": 107792, "crc64": "EBF218CBE6468AAE", "md5": "E0A32F5A18DA7B7C5695A04F66585B2E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 4, "Domain": 2, "Binding site": 6, "Site": 2, "Disulfide bond": 2}, "uniParcId": "UPI0032451F31"}, "cluster_size": 2, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAD9NNK4", "uniProtkbId": "A0AAD9NNK4_RIDPI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ridgeia piscesae", "commonName": "Tubeworm", "taxonId": 27915, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2173694.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001209878"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Sedentaria", "Canalipalpata", "Sabellida", "Siboglinidae", "Ridgeia"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0008006", "source": "Google", "id": "ProtNLM"}], "value": "Ig-like domain-containing protein"}}}, "genes": [{"orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2173694.1"}], "value": "NP493_856g01023"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2173694.1"}], "value": "The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}], "commentType": "CAUTION"}], "features": [{"type": "Domain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 72, "modifier": "EXACT"}}, "description": "Chitin-binding type-2", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50940"}]}, {"type": "Domain", "location": {"start": {"value": 242, "modifier": "EXACT"}, "end": {"value": 323, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047216"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001209878"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "37494294", "citationType": "journal article", "authors": ["Perez M.", "Aroh O.", "Sun Y.", "Lan Y.", "Juniper S.K.", "Young C.R.", "Angers B.", "Qian P.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37494294"}, {"database": "DOI", "id": "10.1093/molbev/msad172"}], "title": "Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.", "publicationDate": "2023", "journal": "Mol. Biol. Evol.", "firstPage": "msad172", "lastPage": "msad172", "volume": "40"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2173694.1"}], "value": "R07B-5", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2173694.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "JAODUO010000855", "properties": [{"key": "ProteinId", "value": "KAK2173694.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP001209878", "properties": [{"key": "Component", "value": "Unassembled WGS sequence"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008061", "properties": [{"key": "GoTerm", "value": "F:chitin binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "2.20.100.10:FF:000001", "properties": [{"key": "EntryName", "value": "semaphorin-5A isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.20.20.80", "properties": [{"key": "EntryName", "value": "Glycosidases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.20.100.10", "properties": [{"key": "EntryName", "value": "Thrombospondin type-1 (TSP1) repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008969", "properties": [{"key": "EntryName", "value": "CarboxyPept-like_regulatory"}]}, {"database": "InterPro", "id": "IPR002557", "properties": [{"key": "EntryName", "value": "Chitin-bd_dom"}]}, {"database": "InterPro", "id": "IPR036508", "properties": [{"key": "EntryName", "value": "Chitin-bd_dom_sf"}]}, {"database": "InterPro", "id": "IPR039675", "properties": [{"key": "EntryName", "value": "CILP1/CILP2"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR003598", "properties": [{"key": "EntryName", "value": "Ig_sub2"}]}, {"database": "InterPro", "id": "IPR000884", "properties": [{"key": "EntryName", "value": "TSP1_rpt"}]}, {"database": "InterPro", "id": "IPR036383", "properties": [{"key": "EntryName", "value": "TSP1_rpt_sf"}]}, {"database": "PANTHER", "id": "PTHR15031:SF6", "properties": [{"key": "EntryName", "value": "CARTILAGE INTERMEDIATE LAYER PROTEIN 1-LIKE ISOFORM X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR15031", "properties": [{"key": "EntryName", "value": "CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01607", "properties": [{"key": "EntryName", "value": "CBM_14"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13927", "properties": [{"key": "EntryName", "value": "Ig_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00090", "properties": [{"key": "EntryName", "value": "TSP_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00408", "properties": [{"key": "EntryName", "value": "IGc2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00209", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49464", "properties": [{"key": "EntryName", "value": "Carboxypeptidase regulatory domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57625", "properties": [{"key": "EntryName", "value": "Invertebrate chitin-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF82895", "properties": [{"key": "EntryName", "value": "TSP-1 type 1 repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50940", "properties": [{"key": "EntryName", "value": "CHIT_BIND_II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50092", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYVVVTEAKTTGPRCVKSCRGKRNGYYQSCRGCHVYITCSNGRTYDNRPCPARLVWDDRTKRCQYKSKTCAEYKGLPINGKWSEWRPWSKCSKSCGGGVHSRIRRCDDPKPENRGTPCRGVSRETAPCATWDCPDCRSDCPPGGKLSKDCAVCECSGAKLTGQVLNMAGDTIPLVGVGVYIVGREWHPSATTDLQGKFELKDLCIIGLKLTFKKTGFMSELPVYNAEHSNPIVIKMIKLERPTFTIEPQDSAGFVGDNVVLRCQATAVPAPSAYDWFKDDNLVKSDPAADESFISELELSPLKVSDAGLYGCRAVSRAGKKFSQFAVLTVNQGNPETGRRKRDADIDTCEATPKKGVNLYKLAETCTAKVNGKHVDQVDLGRCGAKACRNGENYAISRCCRPVQTANVLVTCAGYEFTLPVATVCGCSVCDAGGGIGVNGIVDTGLVNTVPQVDIFAGGRKYGLYNRRHFYFETTAEAGRVVFRVVPWRNFMPQVVSIDVASLGISEVYVQVNLVKRPRRVTINATIGGSVALVSEGQPSAGRVFIPPYATVDQYGMPVVGFIDVYISFADPRVPNGLSGAPGELTFLDEEGETRFLHSYGIMTLVVEQNYDEPVFLQGPLNVKLNARNLGLRRLRNGQANALLWTFDTKMGNWERLTTLKFPGRRQRNQATARPEFPAEYPIIKNIDEPLPVKDICEVSVYVYHDDDFVQPLPGELVVVLTSSRTGVITRSTGLTNEDGRACVAVPCGYKHTVTVGISSRDVIVVSRDHKLPPKFRFKNIKSYGVNFTSPSIDNLVNENGPIFPYRKCRNPIPKSRHYHFAMAVLNLRPAVQGQLAPVETRPGQALSWYQEPGTSDQKEACMVRLDVLTLDPQRTEVVGESRRNGIDGPFYGAYMARVSQALNPFSFVPLRGNYRACVQVRCPTSGDEPTTVNLQLSHPNRKSCVFKWTPLGATENVTTSNAGMSLMIPKESRENIGFYRARGPGNSAYRQVLNDCGRGGPYAALFDCAGGEVTHLGWG", "length": 1020, "molWeight": 112139, "crc64": "141441F2010F2EC9", "md5": "4831FB0EE4BE4260255BC15522040077"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Domain": 2}, "uniParcId": "UPI0028847517"}, "cluster_size": 1, "family": "Siboglinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFF2", "uniProtkbId": "A0AAU7VFF2_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67476.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67476.1"}], "value": "Pumilio-like protein 2"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67476.1"}], "value": "pumilio2"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 800, "modifier": "EXACT"}, "end": {"value": 1140, "modifier": "EXACT"}}, "description": "PUM-HD", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50303"}]}, {"type": "Repeat", "location": {"start": {"value": 820, "modifier": "EXACT"}, "end": {"value": 855, "modifier": "EXACT"}}, "description": "Pumilio", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00317"}]}, {"type": "Repeat", "location": {"start": {"value": 856, "modifier": "EXACT"}, "end": {"value": 891, "modifier": "EXACT"}}, "description": "Pumilio", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00317"}]}, {"type": "Repeat", "location": {"start": {"value": 892, "modifier": "EXACT"}, "end": {"value": 927, "modifier": "EXACT"}}, "description": "Pumilio", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00317"}]}, {"type": "Repeat", "location": {"start": {"value": 928, "modifier": "EXACT"}, "end": {"value": 963, "modifier": "EXACT"}}, "description": "Pumilio", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00317"}]}, {"type": "Repeat", "location": {"start": {"value": 964, "modifier": "EXACT"}, "end": {"value": 999, "modifier": "EXACT"}}, "description": "Pumilio", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00317"}]}, {"type": "Repeat", "location": {"start": {"value": 1000, "modifier": "EXACT"}, "end": {"value": 1035, "modifier": "EXACT"}}, "description": "Pumilio", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00317"}]}, {"type": "Repeat", "location": {"start": {"value": 1036, "modifier": "EXACT"}, "end": {"value": 1071, "modifier": "EXACT"}}, "description": "Pumilio", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00317"}]}, {"type": "Repeat", "location": {"start": {"value": 1075, "modifier": "EXACT"}, "end": {"value": 1114, "modifier": "EXACT"}}, "description": "Pumilio", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00317"}]}, {"type": "Region", "location": {"start": {"value": 178, "modifier": "EXACT"}, "end": {"value": 201, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 214, "modifier": "EXACT"}, "end": {"value": 253, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 276, "modifier": "EXACT"}, "end": {"value": 305, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 424, "modifier": "EXACT"}, "end": {"value": 443, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 459, "modifier": "EXACT"}, "end": {"value": 479, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 513, "modifier": "EXACT"}, "end": {"value": 542, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 190, "modifier": "EXACT"}, "end": {"value": 201, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 283, "modifier": "EXACT"}, "end": {"value": 301, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 428, "modifier": "EXACT"}, "end": {"value": 441, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67476.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67476.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750681", "properties": [{"key": "ProteinId", "value": "XBW67476.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0003730", "properties": [{"key": "GoTerm", "value": "F:mRNA 3'-UTR binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0010608", "properties": [{"key": "GoTerm", "value": "P:post-transcriptional regulation of gene expression"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd07920", "properties": [{"key": "EntryName", "value": "Pumilio"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.25.10.10:FF:000004", "properties": [{"key": "EntryName", "value": "Pumilio homolog 1 isoform 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.25.10.10", "properties": [{"key": "EntryName", "value": "Leucine-rich Repeat Variant"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR011989", "properties": [{"key": "EntryName", "value": "ARM-like"}]}, {"database": "InterPro", "id": "IPR016024", "properties": [{"key": "EntryName", "value": "ARM-type_fold"}]}, {"database": "InterPro", "id": "IPR033133", "properties": [{"key": "EntryName", "value": "PUM-HD"}]}, {"database": "InterPro", "id": "IPR033712", "properties": [{"key": "EntryName", "value": "Pumilio_RNA-bd"}]}, {"database": "InterPro", "id": "IPR001313", "properties": [{"key": "EntryName", "value": "Pumilio_RNA-bd_rpt"}]}, {"database": "PANTHER", "id": "PTHR12537:SF12", "properties": [{"key": "EntryName", "value": "MATERNAL PROTEIN PUMILIO"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12537", "properties": [{"key": "EntryName", "value": "RNA BINDING PROTEIN PUMILIO-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00806", "properties": [{"key": "EntryName", "value": "PUF"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "SMART", "id": "SM00025", "properties": [{"key": "EntryName", "value": "Pumilio"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "SUPFAM", "id": "SSF48371", "properties": [{"key": "EntryName", "value": "ARM repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50302", "properties": [{"key": "EntryName", "value": "PUM"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "PROSITE", "id": "PS50303", "properties": [{"key": "EntryName", "value": "PUM_HD"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPVLTMQETNSWEDARSMLGNDSDIASLTGSMDGRGPGGVASGNVVSRSQDDARVGYFFQRPQAVMLNQQFNNKRWAGDEAFPEQARTVTDLEREFHRLAFENSEEDATLKMWTTNAGNLSRSSGGVDGNLSDSAVGKSGSAGMFQLASLPNNPWLPREDFWGGGPQADTSTLSDLMHTATGHRRPGSFPGSTDLSQHGADNSNLGINMAEYVLGTSPGMSGPGPIKDNMDVRQRQQQALSRRYVGGSDADNSRLEQDQDALHMNGVLQNGLEEKSFSRAPGSRQNSPTEADHQSTMSGPHQSMAHKLNTSLTSAVAGNNISMETMSGYGMLTSAGVGGVMGGINNGMGGINNGMGGFNNGMGGMNNGMGGMNNGMGGMNNGMGMAIDNMGMPHMGGLTLDVPQQMEIMGFDPFQGAIYQNHLMQGGQPPPQPGAAPPPMESPNFSIDYTHQMMQAAARQQQQQQQAAAIGPPQMMMPGQQQYALPTDQILGQTMMPQFYNVQPSWPMYQPQAMLHQQQQQRQQQLQSGQQTPTGPGTPQPVQQLLRTQMPTRPMTPQQQQQQQMDAMTPIQTPGAGGPGFQVITPAFYDQNGQLFMNTLNSSRHVVRLVSPGHPAVLMTGGQQGYAAPAYTPTVSTGMLTPRASATPVFLNPQQGMNPGNPGGAGGIGPIGTGLVQPRRDSFGSLDLKQLTFAGAPQFNQWYGGAASLSPGGAIGIAHTMTPPPNNPGLLLPGLGLNAAIAPPGRLYSAAPGAEAKYRNGSLTLNPAVGQPGSMGLFGTSLFNQQTFSKSDGISKDVAGRSQLLEDFRNNRMPNLQLRDLVDHVVEFSQDQHGSRFIQQKLEHANASEKLMVFNEILSSAHGLMTDVFGNYVIQKFLEFGSTEQKHMLTQRVRGHVLALALHMYGCRVIQKALESVPLEMQVEVLKELEGHILKCVKDQNGNHVVQKCIECIEPAHLSFITDSFKGQVLNLAMHPYGCRVIQRILEHCTAEQIACIMDELREHTEHLVFDQYGNYVIQHVLEHGRPDDKTLIVNQLRGKILPLSQHKFASNVIEKCVSHASRAERALIIEEVCNMNDGAQSALYTMMKDQFANYVVQKMIDIADPAQRKLLLQKIRPHVATLRKYAYGKHILAKLEKFYAKNNAELGPIGNPISNSSSNSSSS", "length": 1164, "molWeight": 126053, "crc64": "835843FF3DA089DD", "md5": "3F0E5E0100D04CE1B8ED8B066773F747"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Repeat": 8, "Region": 6, "Compositional bias": 3}, "uniParcId": "UPI0035D382C9"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBN0", "uniProtkbId": "A0AAU6PBN0_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Protohermes xanthodes", "taxonId": 1452977, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59958.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Megaloptera", "Corydalidae", "Corydalinae", "Protohermes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59958.1"}], "value": "Nicotinic acetylcholine receptor alpha9"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 426, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043492837"}, {"type": "Transmembrane", "location": {"start": {"value": 252, "modifier": "EXACT"}, "end": {"value": 270, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 277, "modifier": "EXACT"}, "end": {"value": 298, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 310, "modifier": "EXACT"}, "end": {"value": 331, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 401, "modifier": "EXACT"}, "end": {"value": 422, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 243, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel ligand-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02931"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59958.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38879304", "citationType": "journal article", "authors": ["Yang J.", "Wen X.", "Zou J.", "Huang X.", "Wu T.", "Huang X."], "citationCrossReferences": [{"database": "PubMed", "id": "38879304"}], "title": "De novo transcriptome analysis of Protohermes xanthodes Navas (Megaloptera: Corydalidae) reveling the effects of sublethal chlorpyrifos on the expression of cholinergic neuronal genes.", "publicationDate": "2024", "journal": "Pestic. Biochem. Physiol.", "firstPage": "0", "lastPage": "0", "volume": "202"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59958.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-CQT4T7LJ8MPGH", "citationType": "submission", "authors": ["Huang X."], "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59958.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP239124", "properties": [{"key": "ProteinId", "value": "WXH59958.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005230", "properties": [{"key": "GoTerm", "value": "F:extracellular ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004888", "properties": [{"key": "GoTerm", "value": "F:transmembrane signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd18989", "properties": [{"key": "EntryName", "value": "LGIC_ECD_cation"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.70.170.10:FF:000028", "properties": [{"key": "EntryName", "value": "AcetylCholine Receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.70.170.10", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel ligand-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.390", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006202", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd"}]}, {"database": "InterPro", "id": "IPR036734", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd_sf"}]}, {"database": "InterPro", "id": "IPR006201", "properties": [{"key": "EntryName", "value": "Neur_channel"}]}, {"database": "InterPro", "id": "IPR036719", "properties": [{"key": "EntryName", "value": "Neuro-gated_channel_TM_sf"}]}, {"database": "InterPro", "id": "IPR038050", "properties": [{"key": "EntryName", "value": "Neuro_actylchol_rec"}]}, {"database": "PANTHER", "id": "PTHR18945", "properties": [{"key": "EntryName", "value": "NEUROTRANSMITTER GATED ION CHANNEL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02931", "properties": [{"key": "EntryName", "value": "Neur_chan_LBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00252", "properties": [{"key": "EntryName", "value": "NRIONCHANNEL"}]}, {"database": "SUPFAM", "id": "SSF90112", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane pore"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63712", "properties": [{"key": "EntryName", "value": "Nicotinic receptor ligand binding domain-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFSTKYFVICILFLIPVALADDDDDCPSKGGVQETLKKLKNDILCNYDRSFRPVLDSKTTVVVTIAIMFKFFEFTDLSNQMQINYWLVLKWNDEYLNWKPADYNGIPNFHIDTDSIWIPDISIYNSADMSSSRTSMSGFSCMLRATGNITCVIPIRHDALCKSNVKQWPFDTQKCTVRVGSWIYSGEEVGFRLVKPSVSLGDYTPNREWELISANASINPGVIICCPNRTYPHIDYKFNIVRHATAITTTTIIPAAIFAVITLAAMFASWDSQERYFFCGLNLVLHLLILENLVWILPPNGLECPIILTYFKDSLLMAAFGILEGLFLRYISTSSLTTSNWLTAFINMMVNCRPGQILLLSKLDPKAVAAATGTNTEEGGDLVVNVPTPGCSKEWLILVNFIDRICFIGYILAYIIMGALIIPKPS", "length": 426, "molWeight": 47860, "crc64": "F80CCA65CF187213", "md5": "D346B3B05DC55CEBA357050A114DA1FB"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 4, "Domain": 1}, "uniParcId": "UPI0035D38202"}, "cluster_size": 1, "family": "Corydalidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0UJ91", "uniProtkbId": "A0AAU0UJ91_ARGRE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Argyrosomus regius", "commonName": "Meagre", "taxonId": 172269, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRH06998.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Neoteleostei", "Acanthomorphata", "Eupercaria", "Sciaenidae", "Argyrosomus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRH06998.1"}], "value": "Matrix metallopeptidase 9"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRH06998.1"}], "value": "mmp9"}}], "features": [{"type": "Repeat", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 59, "modifier": "EXACT"}}, "description": "Hemopexin", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01011"}]}, {"type": "Repeat", "location": {"start": {"value": 60, "modifier": "EXACT"}, "end": {"value": 94, "modifier": "EXACT"}}, "description": "Hemopexin", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01011"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRH06998.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 94, "modifier": "EXACT"}, "end": {"value": 94, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRH06998.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1INEMGUQ3VHLD", "citationType": "submission", "authors": ["Rocha A."], "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRH06998.1"}], "value": "Meagre", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRH06998.1"}], "value": "Head kidney", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRH06998.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP065952", "properties": [{"key": "ProteinId", "value": "WRH06998.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.110.10.10", "properties": [{"key": "EntryName", "value": "Hemopexin-like domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036375", "properties": [{"key": "EntryName", "value": "Hemopexin-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR018487", "properties": [{"key": "EntryName", "value": "Hemopexin-like_repeat"}]}, {"database": "Pfam", "id": "PF00045", "properties": [{"key": "EntryName", "value": "Hemopexin"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00120", "properties": [{"key": "EntryName", "value": "HX"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF50923", "properties": [{"key": "EntryName", "value": "Hemopexin-like domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51642", "properties": [{"key": "EntryName", "value": "HEMOPEXIN_2"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "RSIEKLGLPNTVQKVEGALQRGKGKVLLFSGESFWRLDVKAQKIDKGYPRYTDAVFGGIPNDAHDVFQYKGHFYFCRDRFYWRMNSRRQVDRVG", "length": 94, "molWeight": 11017, "crc64": "3F9F8638B42844E6", "md5": "C2581FB3AEB7A55DC9AC310561217BE7"}, "extraAttributes": {"countByFeatureType": {"Repeat": 2, "Non-terminal residue": 2}, "uniParcId": "UPI0035D3ACED"}, "cluster_size": 1, "family": "Sciaenidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LL47", "uniProtkbId": "A0AAU7LL47_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28269.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28269.1"}], "value": "MADS74"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28269.1"}], "value": "MADS74"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 51, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28269.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28269.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400909", "properties": [{"key": "ProteinId", "value": "XBP28269.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00266", "properties": [{"key": "EntryName", "value": "MADS_SRF_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR033897", "properties": [{"key": "EntryName", "value": "SRF-like_MADS-box"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR11945:SF521", "properties": [{"key": "EntryName", "value": "AGAMOUS-LIKE 48-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11945", "properties": [{"key": "EntryName", "value": "MADS BOX PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTRKKVKLVWIANDSARKASFKKRKQGLLKKVKELTTLCDVSALVIIYGPNDNEAAIWPSHPIVEELLARFESIPEIERCKKMMNQETYLKERGLKMHEQLRKHHKKNGEKEMGYMMHQINQGKQFIEFQTSELTNFFWMIDDKMKEIRRRAEYIQHVPLPPVSLPPPPFQGAAPTGGNMIMGETWWDNIYADIIKNKGSSTARATSSVRSETGFPYGSTANELGLQFGSFPYRGFNEAGRTGPGMENFGGTNRESSEMSLALGLPHNNYNSYNSSNAMDFHEYMGHNITRLNQNDNLQGVQKGGNSTIGSDLGFPSNLFTGSSTAGSDAGLPYDVTKAWLTPPSP", "length": 346, "molWeight": 38807, "crc64": "D88C95A8C8D4275B", "md5": "9D07EF9B1B41D326873A14E2DBE2E309"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D2BD80"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DRG1", "uniProtkbId": "CRY16_TITOB", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tityus obscurus", "commonName": "Amazonian scorpion", "synonyms": ["Tityus cambridgei"], "taxonId": 1221240, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Scorpiones", "Buthida", "Buthoidea", "Buthidae", "Tityus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "28918200"}], "value": "Cryptide Pep-16"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "28918200"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}], "features": [{"type": "Peptide", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 12, "modifier": "EXACT"}}, "description": "Cryptide Pep-16", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}], "featureId": "PRO_0000461751"}], "keywords": [{"id": "KW-0903", "category": "Technical term", "name": "Direct protein sequencing"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}], "references": [{"referenceNumber": 1, "citation": {"id": "28918200", "citationType": "journal article", "authors": ["Dias N.B.", "de Souza B.M.", "Cocchi F.K.", "Chalkidis H.M.", "Dorce V.A.C.", "Palma M.S."], "citationCrossReferences": [{"database": "PubMed", "id": "28918200"}, {"database": "DOI", "id": "10.1016/j.jprot.2017.09.006"}], "title": "Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.", "publicationDate": "2018", "journal": "J. Proteomics", "firstPage": "70", "lastPage": "79", "volume": "170"}, "referencePositions": ["PROTEIN SEQUENCE", "IDENTIFICATION BY MASS SPECTROMETRY", "SUBCELLULAR LOCATION"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}], "sequence": {"value": "PHWLFFGVSVLC", "length": 12, "molWeight": 1405, "crc64": "DE88A2F8B2C879C9", "md5": "86C2577AE16FB7266D52C7B4A29C89BB"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1}, "countByFeatureType": {"Peptide": 1}, "uniParcId": "UPI00388C3399"}, "cluster_size": 1, "family": "Buthidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P9W9", "uniProtkbId": "A0AAF0P9W9_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenuipotamon huaningense", "taxonId": 511399, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59285.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00029569"}], "value": "Rotamase"}}, "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59285.1"}], "value": "scaffold2067350"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59285.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 189, "modifier": "EXACT"}, "end": {"value": 189, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59285.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59285.1"}], "id": "KW-0413", "category": "Molecular function", "name": "Isomerase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59285.1"}], "value": "HNHX", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59285.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59285.1"}], "value": "HNHX", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59285.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515408", "properties": [{"key": "ProteinId", "value": "WMS59285.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016853", "properties": [{"key": "GoTerm", "value": "F:isomerase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.25.40.10", "properties": [{"key": "EntryName", "value": "Tetratricopeptide repeat domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050754", "properties": [{"key": "EntryName", "value": "FKBP4/5/8-like"}]}, {"database": "InterPro", "id": "IPR011990", "properties": [{"key": "EntryName", "value": "TPR-like_helical_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR46512", "properties": [{"key": "EntryName", "value": "PEPTIDYLPROLYL ISOMERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46512:SF9", "properties": [{"key": "EntryName", "value": "PEPTIDYLPROLYL ISOMERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48452", "properties": [{"key": "EntryName", "value": "TPR-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VSLQEVCCSCEMKLLESKYINSKAFESYILGDATTALDRALETAFSLMSNEETANIVVSLPGKLVDLPESVSVTCTAHLRIIENNKMVYELSAAEKLGIAVKYKNTGVTLYKEGLLHKQILAFFMFSDGVKWLCMIGPEEGEDLSKEATTIKMQCYNNIALFHLQQQNYRLCIAAATTLLNVDGSNVKA", "length": 189, "molWeight": 20888, "crc64": "B2914ECB0BD93D52", "md5": "5FA5B029AA119CACB9DE50DD2872AC19"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI002B2D3D2D"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N6K3", "uniProtkbId": "A0AAJ6N6K3_9ASCI", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ciona robusta", "taxonId": 1774208, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8T05"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Tunicata", "Ascidiacea", "Phlebobranchia", "Cionidae", "Ciona"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8T05"}], "value": "Myomaker"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005542"}], "value": "Belongs to the TMEM8 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 35, "modifier": "EXACT"}, "end": {"value": 59, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 83, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 117, "modifier": "EXACT"}, "end": {"value": 134, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 154, "modifier": "EXACT"}, "end": {"value": 174, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 180, "modifier": "EXACT"}, "end": {"value": 200, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8T05"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8T05"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "37770716", "citationType": "journal article", "authors": ["Long T.", "Zhang Y.", "Donnelly L.", "Li H.", "Pien Y.C.", "Liu N.", "Olson E.N.", "Li X."], "citationCrossReferences": [{"database": "PubMed", "id": "37770716"}, {"database": "DOI", "id": "10.1038/s41594-023-01110-8"}], "title": "Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.", "publicationDate": "2023", "journal": "Nat. Struct. Mol. Biol.", "firstPage": "1746", "lastPage": "1754", "volume": "30"}, "referencePositions": ["STRUCTURE BY ELECTRON MICROSCOPY (3.22 ANGSTROMS)", "DISULFIDE BONDS"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8T05"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8T05", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "3.22 A"}, {"key": "Chains", "value": "A/B=1-219"}]}, {"database": "EMDB", "id": "EMD-40935", "properties": [{"key": "Description", "value": "-"}]}, {"database": "SMR", "id": "A0AAJ6N6K3", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "InterPro", "id": "IPR021910", "properties": [{"key": "EntryName", "value": "NGX6/PGAP6/MYMK"}]}, {"database": "PANTHER", "id": "PTHR14319", "properties": [{"key": "EntryName", "value": "FIVE-SPAN TRANSMEMBRANE PROTEIN M83"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14319:SF7", "properties": [{"key": "EntryName", "value": "POST-GPI ATTACHMENT TO PROTEINS FACTOR 6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF12036", "properties": [{"key": "EntryName", "value": "DUF3522"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGLILVKFLLPAISSGAFFIPGIFATKKRLFTLAFLYIFTAFFQLFFHLCTTPLLSLLFCLMGKKLLTFFSTYGLVLSIYSTLTQLTRYTDDRKHSAVVCGGLLIGVRIFQENEGPGVYAGPLITGGLLLAISWGQEMYRSKALYPDKEKWLKIILPSFALGAVSLLLLCVFQNSWNYAFVHSIHHLLMSAAITIILRLVEDGEKQDKCCGLSIACCIC", "length": 219, "molWeight": 24384, "crc64": "9930926C2D871F73", "md5": "F6DCD98952E3FDF895DA072E63F0DA1E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 5, "Disulfide bond": 1}, "uniParcId": "UPI00089DA8A3"}, "cluster_size": 1, "family": "Cionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB32U4Q7", "uniProtkbId": "A0AB32U4Q7_DANRE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Danio rerio", "commonName": "Zebrafish", "synonyms": ["Brachydanio rerio"], "taxonId": 7955, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}, {"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080460.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Cypriniformes", "Danionidae", "Danioninae", "Danio"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080460.1"}], "value": "Platelet binding protein GspB-like"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080460.1"}], "value": "LOC137496709"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 1579, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044206851"}, {"type": "Region", "location": {"start": {"value": 90, "modifier": "EXACT"}, "end": {"value": 178, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1047, "modifier": "EXACT"}, "end": {"value": 1198, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1213, "modifier": "EXACT"}, "end": {"value": 1241, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1257, "modifier": "EXACT"}, "end": {"value": 1395, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1414, "modifier": "EXACT"}, "end": {"value": 1543, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 98, "modifier": "EXACT"}, "end": {"value": 113, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 114, "modifier": "EXACT"}, "end": {"value": 131, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 132, "modifier": "EXACT"}, "end": {"value": 178, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1047, "modifier": "EXACT"}, "end": {"value": 1097, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1098, "modifier": "EXACT"}, "end": {"value": 1134, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1155, "modifier": "EXACT"}, "end": {"value": 1167, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1168, "modifier": "EXACT"}, "end": {"value": 1181, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1182, "modifier": "EXACT"}, "end": {"value": 1198, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1220, "modifier": "EXACT"}, "end": {"value": 1241, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1257, "modifier": "EXACT"}, "end": {"value": 1271, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1272, "modifier": "EXACT"}, "end": {"value": 1301, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1302, "modifier": "EXACT"}, "end": {"value": 1354, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1372, "modifier": "EXACT"}, "end": {"value": 1395, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1414, "modifier": "EXACT"}, "end": {"value": 1458, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1466, "modifier": "EXACT"}, "end": {"value": 1543, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AB32U4Q7"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "23594743", "citationType": "journal article", "authoringGroup": ["Genome Reference Consortium Zebrafish"], "authors": ["Howe K.", "Clark M.D.", "Torroja C.F.", "Torrance J.", "Berthelot C.", "Muffato M.", "Collins J.E.", "Humphray S.", "McLaren K.", "Matthews L.", "McLaren S.", "Sealy I.", "Caccamo M.", "Churcher C.", "Scott C.", "Barrett J.C.", "Koch R.", "Rauch G.J.", "White S.", "Chow W.", "Kilian B.", "Quintais L.T.", "Guerra-Assuncao J.A.", "Zhou Y.", "Gu Y.", "Yen J.", "Vogel J.H.", "Eyre T.", "Redmond S.", "Banerjee R.", "Chi J.", "Fu B.", "Langley E.", "Maguire S.F.", "Laird G.K.", "Lloyd D.", "Kenyon E.", "Donaldson S.", "Sehra H.", "Almeida-King J.", "Loveland J.", "Trevanion S.", "Jones M.", "Quail M.", "Willey D.", "Hunt A.", "Burton J.", "Sims S.", "McLay K.", "Plumb B.", "Davis J.", "Clee C.", "Oliver K.", "Clark R.", "Riddle C.", "Elliot D.", "Eliott D.", "Threadgold G.", "Harden G.", "Ware D.", "Begum S.", "Mortimore B.", "Mortimer B.", "Kerry G.", "Heath P.", "Phillimore B.", "Tracey A.", "Corby N.", "Dunn M.", "Johnson C.", "Wood J.", "Clark S.", "Pelan S.", "Griffiths G.", "Smith M.", "Glithero R.", "Howden P.", "Barker N.", "Lloyd C.", "Stevens C.", "Harley J.", "Holt K.", "Panagiotidis G.", "Lovell J.", "Beasley H.", "Henderson C.", "Gordon D.", "Auger K.", "Wright D.", "Collins J.", "Raisen C.", "Dyer L.", "Leung K.", "Robertson L.", "Ambridge K.", "Leongamornlert D.", "McGuire S.", "Gilderthorp R.", "Griffiths C.", "Manthravadi D.", "Nichol S.", "Barker G.", "Whitehead S.", "Kay M.", "Brown J.", "Murnane C.", "Gray E.", "Humphries M.", "Sycamore N.", "Barker D.", "Saunders D.", "Wallis J.", "Babbage A.", "Hammond S.", "Mashreghi-Mohammadi M.", "Barr L.", "Martin S.", "Wray P.", "Ellington A.", "Matthews N.", "Ellwood M.", "Woodmansey R.", "Clark G.", "Cooper J.", "Cooper J.", "Tromans A.", "Grafham D.", "Skuce C.", "Pandian R.", "Andrews R.", "Harrison E.", "Kimberley A.", "Garnett J.", "Fosker N.", "Hall R.", "Garner P.", "Kelly D.", "Bird C.", "Palmer S.", "Gehring I.", "Berger A.", "Dooley C.M.", "Ersan-Urun Z.", "Eser C.", "Geiger H.", "Geisler M.", "Karotki L.", "Kirn A.", "Konantz J.", "Konantz M.", "Oberlander M.", "Rudolph-Geiger S.", "Teucke M.", "Lanz C.", "Raddatz G.", "Osoegawa K.", "Zhu B.", "Rapp A.", "Widaa S.", "Langford C.", "Yang F.", "Schuster S.C.", "Carter N.P.", "Harrow J.", "Ning Z.", "Herrero J.", "Searle S.M.", "Enright A.", "Geisler R.", "Plasterk R.H.", "Lee C.", "Westerfield M.", "de Jong P.J.", "Zon L.I.", "Postlethwait J.H.", "Nusslein-Volhard C.", "Hubbard T.J.", "Roest Crollius H.", "Rogers J.", "Stemple D.L."], "citationCrossReferences": [{"database": "PubMed", "id": "23594743"}, {"database": "DOI", "id": "10.1038/nature12111"}], "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "publicationDate": "2013", "journal": "Nature", "firstPage": "498", "lastPage": "503", "volume": "496"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FT6AD0HQEQTFJ", "citationType": "submission", "authoringGroup": ["RefSeq"], "publicationDate": "APR-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080460.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080460.1"}]}], "uniProtKBCrossReferences": [{"database": "RefSeq", "id": "XP_068080460.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_068224359.1"}]}, {"database": "GeneID", "id": "137496709", "properties": [{"key": "Description", "value": "-"}]}, {"database": "KEGG", "id": "dre:137496709", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000000437", "properties": [{"key": "Component", "value": "Chromosome 11"}]}], "sequence": {"value": "MGDPAIRLLRLSLALLSLCLHGQIKTVYGSEPYPGSYNVGFPMMDGLRPWNLYDQGGFTGPLIPNNMTYTSVKGVYDSASYNPQTGSSGFGVVPNLNKPDSVSNTRGQPQGTPVSSVNSESLVSSSVSTEVDTTGSNESLPTSASLQTSSESQPDMQQPTEASSPLVDQSDIQPVQASSASVAQPISLSAPTSHQSVQAIYQSLAQQPNQASNVPLRLQNVNQPILTSSQSDPQSIGLQSAQAWYPFVSQPIGMQFEPARHPVLQPGAWQFPQATYQSVPQVSSIQSAQSWYQSLSQPSGLQSANKKYQSSVSQSVQPSYQCACQPIGLQSAQASYQCACQPSRLTSTQAQFLSQSATLVSAQVMVMSQSNEPQSTQANYQCACQPVVPSMSKTTGQSSAPLGYQCACQPSSPSLSQPVGPQSAQASYQCACQPSDPSVFQPNAQQSSQTNYQCACQPSSSFVAQPGILQSAQALNQSPSQPITLVSAQVPFTSVSQTYGPQSAQSGYQCSCQLSGQPSGPASYQCACQPSTLQSAKAFYQSLTQSSIFVSAQVRYPTMSPSKGPQFAQASYQCACQPSGLSVSQPNGQPSIPSSYQCACQPSSPSLSQPIGPQQAQASYQCACQPNGQQSSQTNYQCACQPSSSSVSQPGILMSAPALNQSPSQPITLVSAQVPSPSMSQTNGPQSAQSGYQCSCQLGSQSSGPASYQCACQPSSLQSAKAFYQSLTQSSILVSAQVRYPTVSPSKGPQFAQASYQCACQPSGPSVSQPSGQPSIPSSYQCACQPSGPSLSQPIGPQSAQASYQCACQPSDPSVSQPTGQQSAQTNYQCVCQPSSSSVSQPGILQPAQALNQSPSQPITLVSAQVPSPSMFQLSGPQSAQSGYQCSCQLGSQSSGPASYQCACQPSSLQSAKAFYQSLTQSSILVSAQVRYPTMSPSKGPQFAQASYQCACQPSGPSVSQPNGQPSIPSSYQCACQPSSPSLSQPIGQQPAQASYQCACQPNGQMSSQTNYQCACQPSSSSVSQPGILQSAQALNQSPSQPITLVSAQVPSPSVSQPSSPQSQTSTLVSAQVRYPSVSQSSGSPQGSYQCSCQPSGPSVSDPSSQTSQASYQCACQPSDTSVSQPSATQSVPTDSPPEPSSLPSQTSGQPEPQPSSVPTSQTSDQPVSQPSAMQSVQASFQYVPQPSSQSVPQPSGLQSVPVRYQAVPLPTGLQSGQASYQSFPQPSGPQSGKPSYQSASTASGLLAALARYQSIPQSSSLQSSQSNYQSVPQPSGPQSAQAWYQSVPSPSGLQSLQATYQSVSQPSGPQSGRVSYQSSSSGLLAALGRYPSAPQSSSLQSSQSSYQTVQQPSGPQSSQAWYQSLPVPGGLQSSASFQSVTQPSGQMSGQPSYQSVSTASGLLAALARYPSVPQSTNLQSPQASYQSITQPSGPQSAQAWYQTVPSPSGPQLAQVSYLSVPRPSGLQSAQTWYQSLPSPSGSQSAQVSYQSVPQSSGLQSTPTWFQSMSQPNTAQLTPATYQYDSRISDQQSAQGQSEASTYESVFQPGFLDPLQLQFQTTPKRVPYSMSRLLQQVKS", "length": 1579, "molWeight": 164929, "crc64": "F06FDFBE10DBF904", "md5": "978A0C45DAF7B10109DF3D7276A9D37A"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 5, "Compositional bias": 15}, "uniParcId": "UPI0035A08EE1"}, "cluster_size": 1, "family": "Danionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU88", "uniProtkbId": "A0AAT9UU88_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41673.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41673.1"}], "value": "Cytochrome P450 3638A5"}}], "flag": "Fragment"}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 332, "modifier": "EXACT"}, "end": {"value": 332, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}, {"type": "Non-terminal residue", "location": {"start": {"value": 396, "modifier": "EXACT"}, "end": {"value": 396, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41673.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41673.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117233", "properties": [{"key": "ProteinId", "value": "WIM41673.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNPAFSGTMLHRYMSVFNEQAIILSKRLSQQANTATVIDLWEYISDMNFDTVTENMTDYKLHVQETGGNDFSKAVQKALHLESQRINNPILFFSIFFTVFQYITGNGGLSEKINELPAQIVRQKMCEYENEKKKLKDNGVKEEKPEKSLIDFLLKIHETYPEFDENRIRIEILNMIFAGSDTTATTVSLVLLFLGIHPKIQDKVYNEILEVFQDDGRSNYNDTDELGKELGLHVNVNVHQCAKLAYMEQCIKETLRLFTLVPITARKCPEPVKIDDKLTIPANCMISFAYHAVHHNPIVYPNPERFDPDRFAPNNIRNKKDFMGFGAGPRACIGSKYAMLSMKTQLTHILLRYRLTCEMAISDIVHIVDMLSRSQNGYPVKIWRRSNVKSSVHLCR", "length": 396, "molWeight": 45539, "crc64": "96743127CF4A4E93", "md5": "B5552D8E340B4CA9C86B118ECD1BD279"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D3104E"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39J5D7", "uniProtkbId": "A0AB39J5D7_STIJA", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Stichopus japonicus", "commonName": "Sea cucumber", "taxonId": 307972, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88987.1"}], "lineage": ["Eukaryota", "Metazoa", "Echinodermata", "Eleutherozoa", "Echinozoa", "Holothuroidea", "Aspidochirotacea", "Aspidochirotida", "Stichopodidae", "Apostichopus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88987.1"}], "value": "Guanylate binding protein 2"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 35, "modifier": "EXACT"}, "end": {"value": 299, "modifier": "EXACT"}}, "description": "Guanylate-binding protein N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02263"}]}, {"type": "Domain", "location": {"start": {"value": 303, "modifier": "EXACT"}, "end": {"value": 466, "modifier": "EXACT"}}, "description": "Guanylate-binding protein/Atlastin C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02841"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9KB24OKSBOGJC", "citationType": "submission", "authors": ["Yang L.", "Li C."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88987.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ120688", "properties": [{"key": "ProteinId", "value": "XDN88987.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003924", "properties": [{"key": "GoTerm", "value": "F:GTPase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR003191", "properties": [{"key": "EntryName", "value": "Guanylate-bd/ATL_C"}]}, {"database": "InterPro", "id": "IPR036543", "properties": [{"key": "EntryName", "value": "Guanylate-bd_C_sf"}]}, {"database": "InterPro", "id": "IPR015894", "properties": [{"key": "EntryName", "value": "Guanylate-bd_N"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "PANTHER", "id": "PTHR10751", "properties": [{"key": "EntryName", "value": "GUANYLATE BINDING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02263", "properties": [{"key": "EntryName", "value": "GBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02841", "properties": [{"key": "EntryName", "value": "GBP_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48340", "properties": [{"key": "EntryName", "value": "Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEPYPSVPLCLPGNFIWDSHNRHILVDKSKSRGDITVCKEGLAILDSVKDDYVIVICITGPARTGKSYFLSQFQEGVTFEIGHSTTSKTTGIWIALAPNSVTMTDGKIARLVLLDAEGLGSTSTIDHDGCTERWDRKVFTLCALFSSYLIYNSKGVPTSDDLDKLSFMSQFSSSIQGHLSTPGESMETAVDISPYFMWLIRDAVLQPEVDGQNCTWKKFIISSVLCVEAGAAKNSRNAIKAAIKRSFQNFDAHGIPPPSVDPEVVQNLLLAKYKDQINKKFLYRVEEVKNHVLACAQVKVIKGFPITGQQLALYVSSCVSAVNSESDKLPIQNAWESFLEVKWNDTLIATMEKYDDHANQISYPISTEDIESFHVQESSEVQKAFTEFEASNFDERSVKQYREKLNSALKGKLHTIKTINNTKSHNHCEKVARNLELHLTKVENLDNYTFEELLKGRQKVLEEYLRKAIGPSINEVKEALEERMDGKIRTLQPALIQNTIEAVEEVYEREARDTIQDRLPLETNVIDAEYQRIRELCINQFRIRCRGCDGFLNALSRLETDLRKRLQSLQQTNLSLSNDVCEEAMRSSKRKHFDALWNLVSELNIADLQSAKETALAEYERDARGPAKDKVRKEYGEDMDEKLCRAKTLIAEHALTEAKRDYKRELDELLIEGPLDSREASVKCSSICTKIRKHFERRCDGLDDVLSRVYGTNVTKVESDVVKYFHRRNGELSFEYCDKLMTRLIREILKPSIDNIEMLVSYEEKKTSILQKYDESAKGPKAVDVKDAAVLQIDKDIKRAEQQRVLKGIKLGLQALEVAGGVYGAAVGGKAAKIGMTAAMAAKLGQNVFDKTM", "length": 853, "molWeight": 96230, "crc64": "BB85D4A3BBD2B9F3", "md5": "558A9554B20B0F7407B3D73E9498E629"}, "extraAttributes": {"countByFeatureType": {"Domain": 2}, "uniParcId": "UPI00388BD3B4"}, "cluster_size": 3, "family": "Stichopodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6R4E0", "uniProtkbId": "A0AAU6R4E0_PINIB", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pinctada imbricata", "commonName": "Atlantic pearl-oyster", "synonyms": ["Pinctada martensii"], "taxonId": 66713, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC35622.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Bivalvia", "Autobranchia", "Pteriomorphia", "Pterioida", "Pterioidea", "Pteriidae", "Pinctada"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC35622.1"}], "value": "Tumor necrosis factor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004370"}], "value": "Membrane", "id": "SL-0162"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008670"}], "value": "Belongs to the tumor necrosis factor family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 38, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 112, "modifier": "EXACT"}, "end": {"value": 249, "modifier": "EXACT"}}, "description": "THD", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50049"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022514"}], "id": "KW-0202", "category": "Molecular function", "name": "Cytokine"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-E2OTJNSICE4A5", "citationType": "submission", "authors": ["Liang b."], "title": "Characterism and functional analysis of a novel tumor necrosis factor from pearl oyster Pinctada fucata martensii.", "publicationDate": "APR-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC35622.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ889552", "properties": [{"key": "ProteinId", "value": "WZC35622.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005125", "properties": [{"key": "GoTerm", "value": "F:cytokine activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005164", "properties": [{"key": "GoTerm", "value": "F:tumor necrosis factor receptor binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006955", "properties": [{"key": "GoTerm", "value": "P:immune response"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00184", "properties": [{"key": "EntryName", "value": "TNF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006052", "properties": [{"key": "EntryName", "value": "TNF_dom"}]}, {"database": "InterPro", "id": "IPR008983", "properties": [{"key": "EntryName", "value": "Tumour_necrosis_fac-like_dom"}]}, {"database": "PANTHER", "id": "PTHR11471:SF13", "properties": [{"key": "EntryName", "value": "TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11471", "properties": [{"key": "EntryName", "value": "TUMOR NECROSIS FACTOR FAMILY MEMBER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00229", "properties": [{"key": "EntryName", "value": "TNF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00207", "properties": [{"key": "EntryName", "value": "TNF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49842", "properties": [{"key": "EntryName", "value": "TNF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50049", "properties": [{"key": "EntryName", "value": "THD_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MANIKGNIKTCKCLSIGLVFTNIVLLLCTFAITLAWFLQRQKFEPKEHSLLTCLPSASDSKDCFSRVDDLCCSNLTLSDSIKHNTKKRYEEQTNEENTHLAQHCLSSPGNITAARVVGIDKDIAPTAILQWRQNNHGGFLNEVKYLSGRFVIEKNGYYFIYSQVTFIEHSVNEHDKLSHSIYRQTPLNNEKLVESVRSHCRLQTGESDSSRFVGSVFLLNKGDEIYVHVTDPTKVSRAEHANYFGLHII", "length": 249, "molWeight": 28240, "crc64": "39118F47CAF578CD", "md5": "92144BCA25409B91CDAB86FC79F6FE5D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1}, "uniParcId": "UPI0035D3CFBE"}, "cluster_size": 1, "family": "Pteriidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7A3", "uniProtkbId": "A0AAN0N7A3_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34075.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34075.1"}], "value": "Ligated ion channel binding I - glutamate"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 136, "modifier": "EXACT"}, "end": {"value": 155, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 187, "modifier": "EXACT"}, "end": {"value": 203, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 485, "modifier": "EXACT"}, "end": {"value": 503, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 538, "modifier": "EXACT"}, "end": {"value": 558, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 826, "modifier": "EXACT"}, "end": {"value": 845, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 877, "modifier": "EXACT"}, "end": {"value": 897, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1084, "modifier": "EXACT"}, "end": {"value": 1107, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34075.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155001", "properties": [{"key": "ProteinId", "value": "WRW34075.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "InterPro", "id": "IPR052192", "properties": [{"key": "EntryName", "value": "Insect_Ionotropic_Sensory_Rcpt"}]}, {"database": "PANTHER", "id": "PTHR42643", "properties": [{"key": "EntryName", "value": "IONOTROPIC RECEPTOR 20A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR42643:SF24", "properties": [{"key": "EntryName", "value": "IONOTROPIC RECEPTOR 60A"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNSSCKKNIFKLIYNNMKYNNLYSLDKKKNKLTGLIGSNFQRLLDYFQICPIFINIDNFGTKFQNGSFNGVIGALVNGEADFFFKPLYLDINNEYSIPTKVLGVDEILISHKILNKKNHDEDDLTDFLVFEQKINILVFLCFFTVLMFLILFDYFGKKNEPLLQKISEAFKNIFGLSNLKGGFKKKIIHLFFILFSFIFLSIIKNEIKTFKVIVDTSTIITDYYSLKKSEKSLCVISSEKKVTKSTNSLKTTVALIFNDRISKGKLKYFSPENLLSFLKDEDCFYFLSKQSTELITRLSIMSLSLKNYWVNSKPYFESQLILLMSKKIKNQKRFLLNDKVTKAFEYGILLNVFKKIIHSSDLKYKTLLFENLVIFDEKTLKFKGLIGSKYQKLFDYLQICSSFVKIENWGTKFKNGSISGIQGALAKGEADLFFKIFEIDSNNDFSIPTKALDVEENFISHKISIKKINEKEDDLIEFLKFQNEINFLIFFCLIIVVVFLVLFDNFNKKNESLLQKISEALKNIFGLTNLKGGFKKRIIHLFFILFFFIFTSIITNGIKTFKVVVDTSSIITDVNSLLSSNKSLCLLVFGKSVPIFEKAPKGTTLNLIWEDRLLKGRKKLFTFQELFKFYSDYECFYVADKQTTNLNARIALKFLSIKNYWINLNPISQSYQVLFMSKKIDHKKRLYLDYKVTKAFEHGIMSNINKNFDDYLSLNKKTNRLTGLIGNELQKVIDYLQICSLFINEINYGKIYENGTADGALGLLFKGEADFYLKSVLIIENNEYSIPSNAINTEEKFISHKIPNKKKSDDNDDLIDFLKFTNDINFLIFLSLTIVVLSLVFFDYFGNKKESFYTKLSEALKTIIGFQDLKGGFKKKLVFLFFIFFSFVFTSIITNGIKTLKVIVDTSSIITDYESIITSDKSLCLLLSKNQISFLENSPKGTLLYLIRKNRLSKKKFKQFNFYQTFAFLLDYECFYIMNKQLTNINARIGFNYLSLENYWINPKPVMQSYQVFLMSKKISYNRKSYLNNKLTKMLEHGILIYIDKKIIELADRKYQTASKSIFYSLEEYIKKFTKFSSVQINSFYTLFLIFLSVYAIFFLLFIVSFFRP", "length": 1109, "molWeight": 129257, "crc64": "46A805E0F5694E2E", "md5": "272C2B6E6FE0A1965208E8BC63B919A3"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 7}, "uniParcId": "UPI003243BBF7"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF1BW41", "uniProtkbId": "A0AAF1BW41_ERISI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Eriocheir sinensis", "commonName": "Chinese mitten crab", "taxonId": 95602, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPE03564.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Grapsoidea", "Varunidae", "Eriocheir"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPE03564.1"}], "value": "Anti-lipopolysaccharide factor"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPE03564.1"}], "value": "ALF"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPE03564.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023022"}], "id": "KW-0044", "category": "Molecular function", "name": "Antibiotic"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022529"}], "id": "KW-0929", "category": "Molecular function", "name": "Antimicrobial"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-38ADI1M76NPFI", "citationType": "submission", "authors": ["Shen C."], "title": "Integration of transcriptomics and proteomics analysis reveals the molecular mechanism of Eriocheir sinensis gills exposed to heat stress.", "publicationDate": "NOV-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPE03564.1"}], "value": "Gills", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPE03564.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR813948", "properties": [{"key": "ProteinId", "value": "WPE03564.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0042742", "properties": [{"key": "GoTerm", "value": "P:defense response to bacterium"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.30.160.320", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR024509", "properties": [{"key": "EntryName", "value": "Anti-LPS_factor/Scygonadin"}]}, {"database": "InterPro", "id": "IPR038539", "properties": [{"key": "EntryName", "value": "Anti-LPS_factor/Scygonadin_sf"}]}, {"database": "Pfam", "id": "PF11630", "properties": [{"key": "EntryName", "value": "Anti-LPS-SCYG"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "LPSDSRRGKILCSSIGWFCCCWWIRDPPCLPPFLHPFCSMARGYVSLLVAVLVVAGVLHAPTPVQGFDFSAILSSVADTAINRLYVDREINIVDHYCTLNRSPHFYRWELKWRATVTCPGWTPIKGTARNYYSPNTAEREATRDFVRKAVDRGLIEKEDVTEWL", "length": 164, "molWeight": 18736, "crc64": "DF5A89118A1DD3FC", "md5": "EC74D04EA6967A9755582030EFA936F9"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI002B29AACB"}, "cluster_size": 3, "family": "Varunidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHF3", "uniProtkbId": "A0AAQ5BHF3_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519374.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519374.1"}], "value": "Endoglin"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519374.1"}], "value": "ENG"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 330, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042851188"}, {"type": "Region", "location": {"start": {"value": 203, "modifier": "EXACT"}, "end": {"value": 256, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHF3"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHF3"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519374.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15164053", "citationType": "journal article", "authors": ["Humphray S.J.", "Oliver K.", "Hunt A.R.", "Plumb R.W.", "Loveland J.E.", "Howe K.L.", "Andrews T.D.", "Searle S.", "Hunt S.E.", "Scott C.E.", "Jones M.C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Ashwell R.I.", "Babbage A.K.", "Babbage S.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beasley H.", "Beasley O.", "Bird C.P.", "Bray-Allen S.", "Brown A.J.", "Brown J.Y.", "Burford D.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Chen Y.", "Clarke G.", "Clark S.Y.", "Clee C.M.", "Clegg S.", "Collier R.E.", "Corby N.", "Crosier M.", "Cummings A.T.", "Davies J.", "Dhami P.", "Dunn M.", "Dutta I.", "Dyer L.W.", "Earthrowl M.E.", "Faulkner L.", "Fleming C.J.", "Frankish A.", "Frankland J.A.", "French L.", "Fricker D.G.", "Garner P.", "Garnett J.", "Ghori J.", "Gilbert J.G.", "Glison C.", "Grafham D.V.", "Gribble S.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Guy J.", "Hall R.E.", "Hammond S.", "Harley J.L.", "Harrison E.S.", "Hart E.A.", "Heath P.D.", "Henderson C.D.", "Hopkins B.L.", "Howard P.J.", "Howden P.J.", "Huckle E.", "Johnson C.", "Johnson D.", "Joy A.A.", "Kay M.", "Keenan S.", "Kershaw J.K.", "Kimberley A.M.", "King A.", "Knights A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.", "Lloyd D.M.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "McLaren S.", "McLay K.E.", "McMurray A.", "Milne S.", "Nickerson T.", "Nisbett J.", "Nordsiek G.", "Pearce A.V.", "Peck A.I.", "Porter K.M.", "Pandian R.", "Pelan S.", "Phillimore B.", "Povey S.", "Ramsey Y.", "Rand V.", "Scharfe M.", "Sehra H.K.", "Shownkeen R.", "Sims S.K.", "Skuce C.D.", "Smith M.", "Steward C.A.", "Swarbreck D.", "Sycamore N.", "Tester J.", "Thorpe A.", "Tracey A.", "Tromans A.", "Thomas D.W.", "Wall M.", "Wallis J.M.", "West A.P.", "Whitehead S.L.", "Willey D.L.", "Williams S.A.", "Wilming L.", "Wray P.W.", "Young L.", "Ashurst J.L.", "Coulson A.", "Blocker H.", "Durbin R.", "Sulston J.E.", "Hubbard T.", "Jackson M.J.", "Bentley D.R.", "Beck S.", "Rogers J.", "Dunham I."], "citationCrossReferences": [{"database": "PubMed", "id": "15164053"}, {"database": "DOI", "id": "10.1038/nature02465"}], "title": "DNA sequence and analysis of human chromosome 9.", "publicationDate": "2004", "journal": "Nature", "firstPage": "369", "lastPage": "374", "volume": "429"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519374.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519374.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519374.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL157935", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AL162586", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHF3", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714083.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519374.1"}, {"key": "GeneId", "value": "ENSG00000106991.15"}]}, {"database": "HGNC", "id": "HGNC:3349", "properties": [{"key": "GeneName", "value": "ENG"}]}, {"database": "OpenTargets", "id": "ENSG00000106991", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00530000063861", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 9"}]}, {"database": "PROSITE", "id": "PS51257", "properties": [{"key": "EntryName", "value": "PROKAR_LIPOPROTEIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQGVTVLLHAGSQPGHGPHARVAAAYSSLGPGLPLGRRGRPQGGAHPEGPAGPLGRAPDGDGEGGTELRTRGSRCRPHPAGSPLRVLAHRRQPQHADLDHWRILLQDLSREKHSWLQAPRHTSRPPGGGPDAQCQHCGILRGATAGQHCLTSCLQLRW", "length": 330, "molWeight": 35167, "crc64": "A9E46ECC278A9518", "md5": "308E0BC52130BECBFBC1A783804BFBFB"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1}, "uniParcId": "UPI0032D048D1"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHI6", "uniProtkbId": "A0AAN0LHI6_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65903.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65903.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65903.1"}], "value": "UGT"}}], "features": [{"type": "Domain", "location": {"start": {"value": 241, "modifier": "EXACT"}, "end": {"value": 335, "modifier": "EXACT"}}, "description": "Glycosyl transferase family 28 C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF04101"}]}, {"type": "Coiled coil", "location": {"start": {"value": 113, "modifier": "EXACT"}, "end": {"value": 140, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65903.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145356", "properties": [{"key": "ProteinId", "value": "WRV65903.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR007235", "properties": [{"key": "EntryName", "value": "Glyco_trans_28_C"}]}, {"database": "InterPro", "id": "IPR050426", "properties": [{"key": "EntryName", "value": "Glycosyltransferase_28"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48050", "properties": [{"key": "EntryName", "value": "STEROL 3-BETA-GLUCOSYLTRANSFERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48050:SF13", "properties": [{"key": "EntryName", "value": "STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF04101", "properties": [{"key": "EntryName", "value": "Glyco_tran_28_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDSRYKFEIYEYEKKEQNDFINSLVKPLIALPAIDRMKESFKSFDKNVDYFFYVDKEVSKLIKKLKPDYLLCDMSTHLPSVILESKIPYSFIISTNPLILDVENLPVMGLDHGVDEKEKIKAARIELKELRENTLKILEELYAKRNVTYDYKYPMNVPRSDYLTFYIYPRELDYFDDNFRKDYKILQVDAPIANSRLPNPFELPEEFAKLPGKIIYVSLGSLFRPFGDKINFPNNRFIGENFVDQLAVLQVVDMMIAHGGNNTFSECFYFGVPALIFPVMTDQLNNAKRTEETEFGYQMNLMDYTKEELKEKINKILSDKVLIEKTKKVGERIRKENSLEKAVKTFYESLKILKKI", "length": 356, "molWeight": 41861, "crc64": "99D2C40AAB95E881", "md5": "2D93B399AB6A0DE5391DC9C246265CBC"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Coiled coil": 1}, "uniParcId": "UPI00324C976C"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P9Y8", "uniProtkbId": "A0AAF0P9Y8_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenuipotamon panxiense", "taxonId": 2841827, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59300.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59300.1"}], "value": "DNA excision repair protein ERCC-8"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59300.1"}], "value": "scaffold2024146"}}], "features": [{"type": "Repeat", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 41, "modifier": "EXACT"}}, "description": "WD", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00221"}]}, {"type": "Region", "location": {"start": {"value": 130, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59300.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 153, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59300.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00221"}], "id": "KW-0853", "category": "Domain", "name": "WD repeat"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59300.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59300.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59300.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59300.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515423", "properties": [{"key": "ProteinId", "value": "WMS59300.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0031464", "properties": [{"key": "GoTerm", "value": "C:Cul4A-RING E3 ubiquitin ligase complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000109", "properties": [{"key": "GoTerm", "value": "C:nucleotide-excision repair complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043161", "properties": [{"key": "GoTerm", "value": "P:proteasome-mediated ubiquitin-dependent protein catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000209", "properties": [{"key": "GoTerm", "value": "P:protein polyubiquitination"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006283", "properties": [{"key": "GoTerm", "value": "P:transcription-coupled nucleotide-excision repair"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "2.130.10.10", "properties": [{"key": "EntryName", "value": "YVTN repeat-like/Quinoprotein amine dehydrogenase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR042238", "properties": [{"key": "EntryName", "value": "Rad28/ERCC8/Ckn1/ATCSA-1"}]}, {"database": "InterPro", "id": "IPR015943", "properties": [{"key": "EntryName", "value": "WD40/YVTN_repeat-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR036322", "properties": [{"key": "EntryName", "value": "WD40_repeat_dom_sf"}]}, {"database": "InterPro", "id": "IPR001680", "properties": [{"key": "EntryName", "value": "WD40_rpt"}]}, {"database": "PANTHER", "id": "PTHR46202", "properties": [{"key": "EntryName", "value": "DNA EXCISION REPAIR PROTEIN ERCC-8"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46202:SF1", "properties": [{"key": "EntryName", "value": "DNA EXCISION REPAIR PROTEIN ERCC-8"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00400", "properties": [{"key": "EntryName", "value": "WD40"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50978", "properties": [{"key": "EntryName", "value": "WD40 repeat-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50082", "properties": [{"key": "EntryName", "value": "WD_REPEATS_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50294", "properties": [{"key": "EntryName", "value": "WD_REPEATS_REGION"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "QAHKSQVVSLCFTHDGLWLLTFGYDGELKLWNSSTGKKINVNYGEMFTDSRRNLRMAVTPSMYPDLAFLPCKSKVLVLEILTGQLVNVLSGHFSTVYGALYNPSSMNLYTFGNDHNFITWMPKMIESRECEEEEEDDRTPNVPALSKRKRVMR", "length": 153, "molWeight": 17546, "crc64": "F3D7C5A62FCECE5A", "md5": "F2DFA98114613BAB6404260C1EF068C1"}, "extraAttributes": {"countByFeatureType": {"Repeat": 1, "Region": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2F260B"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P9WEJ9", "uniProtkbId": "ATEA_ASPTE", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Aspergillus terreus", "taxonId": 33178, "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Pezizomycotina", "Eurotiomycetes", "Eurotiomycetidae", "Eurotiales", "Aspergillaceae", "Aspergillus", "Aspergillus subgen. Circumdati"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36702957"}], "value": "Arginine-containing cyclodipeptide synthase ateA"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36702957"}], "value": "RCDPS ateA"}], "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}], "value": "6.3.2.-"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36702957"}], "value": "ateA"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}, {"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "36702957"}], "value": "Arginine-containing cyclodipeptide synthase; part of the cluster that mediates the biosynthesis of a highly modified cyclo-arginine-glutamate dipeptide (cRE) (PubMed:36702957). Within the pathway, ateA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Glu diketopiperazine (cRW) from L-arginyl-tRNA(Arg) + L-glutamyl-tRNA(Glu) (PubMed:36702957). Additional enzymes from the cluster then further modify the cyclo-Arg-Glu diketopiperazine (cRW) scaffold (Probable)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "L-glutamyl-tRNA(Glu) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-glutamyl) + tRNA(Glu) + tRNA(Arg) + 2 H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:80419"}, {"database": "Rhea", "id": "RHEA-COMP:9658"}, {"database": "Rhea", "id": "RHEA-COMP:9663"}, {"database": "Rhea", "id": "RHEA-COMP:9673"}, {"database": "Rhea", "id": "RHEA-COMP:9680"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:78442"}, {"database": "ChEBI", "id": "CHEBI:78513"}, {"database": "ChEBI", "id": "CHEBI:78520"}, {"database": "ChEBI", "id": "CHEBI:231490"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:80420"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}]}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}], "value": "Secondary metabolite biosynthesis"}], "commentType": "PATHWAY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P9WEJ7"}], "value": "The conserved DDXXE motif is essential for catalytic activity"}], "commentType": "DOMAIN"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the arginine-containing cyclodipeptide synthase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 545, "modifier": "EXACT"}}, "description": "Arginine-containing cyclodipeptide synthase ateA", "featureId": "PRO_0000461004"}, {"type": "Region", "location": {"start": {"value": 390, "modifier": "EXACT"}, "end": {"value": 433, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Motif", "location": {"start": {"value": 434, "modifier": "EXACT"}, "end": {"value": 438, "modifier": "EXACT"}}, "description": "Conserved DDXXE motif", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P9WEJ7"}]}, {"type": "Compositional bias", "location": {"start": {"value": 390, "modifier": "EXACT"}, "end": {"value": 425, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"id": "KW-0436", "category": "Molecular function", "name": "Ligase"}], "references": [{"referenceNumber": 1, "citation": {"id": "36702957", "citationType": "journal article", "authors": ["Yee D.A.", "Niwa K.", "Perlatti B.", "Chen M.", "Li Y.", "Tang Y."], "citationCrossReferences": [{"database": "PubMed", "id": "36702957"}, {"database": "DOI", "id": "10.1038/s41589-022-01246-6"}], "title": "Genome mining for unknown-unknown natural products.", "publicationDate": "2023", "journal": "Nat. Chem. Biol.", "firstPage": "633", "lastPage": "640", "volume": "19"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "FUNCTION", "CATALYTIC ACTIVITY", "PATHWAY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP622863", "properties": [{"key": "ProteinId", "value": "WCB22922.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016874", "properties": [{"key": "GoTerm", "value": "F:ligase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MDVQYVLADLQTGPESQSSQSSIHFHDMAPFYVVSIERQHGLSGLVSIVPCSTTPTIHYDEKDKKAYQKAWSRGRRFAALFENLLNGGKMATKTSCSLQQTPYLQLRDEALIVGSPLGTPTRTREGISSFHNMEFNFPGAKPVVSSQMLHITCPGLRSEESLFDKNGGALYDSVTVLTGMCLFTRKILDESVADGFLDTRKLLDMQLTLYEVERIAGLSSAIADIAALVLSRYDGKCHKPVNIILDLPTWHYYQSVEDQLQHRGYKPCEVMDWIEAITLRSQQLAGLLKSAVLHELDRRGVSSSQRLYDIQISPGSALVDDAFRETLKYENLPCLDNILEALSGSEDGSWQQFYSLLPERDRPQSIKDLSYLFYIFEVVRPAVLAGIQSGNQQTPTQSADMDSTVSHRQQQPASSRSYTSKQNQMPRPLVISVDDPSERKLYSKAHSFFLRLPKNPIYPADPTLVQVYTTRRVFVDGNRKGERLYRNDPSPVMPELSNGKLYGDGGDAGYSKYARELQQMDFIAKLYGAECAANIQRWSKEVGLC", "length": 545, "molWeight": 61174, "crc64": "012FE8E9FAA86B40", "md5": "087101B96C7BB264843E9B6DC446CF40"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 1, "PATHWAY": 1, "DOMAIN": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Region": 1, "Motif": 1, "Compositional bias": 1}, "uniParcId": "UPI00279FE010"}, "cluster_size": 2, "family": "Aspergillaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTG9", "uniProtkbId": "A0AAT9UTG9_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41641.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41641.1"}], "value": "Cytochrome P450 6PZ31"}}], "flag": "Fragment"}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41641.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 419, "modifier": "EXACT"}, "end": {"value": 419, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41641.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41641.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117201", "properties": [{"key": "ProteinId", "value": "WIM41641.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002402", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-II"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00464", "properties": [{"key": "EntryName", "value": "EP450II"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "LQTKHTLVIASMFIASIFLLIVTISLYLYRRLNSSHKFFDKYGIPYTKPHWFYGHMKEAMQYKKSYVMTLKEIYQESEPHRFIGMYILQRPSVMIRDPELLKKIMIKDFVYFQDHGVYYCKEAEPMSHNLFNMEGDDWKSLRVKLTGTFTSGKMKMMFPLVKKCASNIRPALTSYSTSPEGFDVKDFCARYTTDVIGSCAFGIDTHSLQDPQSEFRTMGKRIFESRWQNFVRAFFENLPAWFITFFRLEQFDKKVTDYFTNIIKDMVKYREENTTSRGDFLDLLIAMKNQKDTEKLKDHQEETDLAKFITQIGDKWVKSNVEMTIELMAAQCFLFFIGGFEGTSATLTFLLFELSQHPDIQDKVRDEITTVIEENNNEISYDLLKKLPYLEMVIFETLRKYGLGLGIRTARKHVNHRRD", "length": 419, "molWeight": 49407, "crc64": "2F509BA7082831C3", "md5": "BD2826E08842ABC70072097D9594D731"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D2BA05"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LP44", "uniProtkbId": "A0AAN0LP44_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65889.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65889.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65889.1"}], "value": "UGT"}}], "features": [{"type": "Domain", "location": {"start": {"value": 287, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "Glycosyl transferase family 28 C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF04101"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65889.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145342", "properties": [{"key": "ProteinId", "value": "WRV65889.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR007235", "properties": [{"key": "EntryName", "value": "Glyco_trans_28_C"}]}, {"database": "InterPro", "id": "IPR050426", "properties": [{"key": "EntryName", "value": "Glycosyltransferase_28"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48050", "properties": [{"key": "EntryName", "value": "STEROL 3-BETA-GLUCOSYLTRANSFERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48050:SF13", "properties": [{"key": "EntryName", "value": "STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF04101", "properties": [{"key": "EntryName", "value": "Glyco_tran_28_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MAALQITDLNIIHDRLMNLIDYFYFGVSPNIFLSFDQSISVKRNEEKRFGYQMDILNFSKKELKEKVNKIMYVDLSFDDEVSVLIKKLKPDYLLCDLVYHMPSLIEFKIPYSFIISCNPLILNHEDFPLYGIGQGIDQIKEIKSAREEFKEIFDFIDKKFQSSYKKLNINFQKKYPVYSPRSDNFSFYIYPKELDYFNEKIKKEYNLLQVDSPVVLSRIPLPYRLSEEFAELPRKIIYVSLGSLFNYYYVLLQKLIDSLANLPYKYIISKGQFGDKIKFPNNHFIGENFVDQLAVLQVADMMIAHGGNNTFTECFYFGVPAIIVPVMGDQMNNAKRIEETEFGLKMNIMNYTQEELKEKIEKVLLDEILFEKIKKVGERIRKEKSLDKAVKNFYESIKDILRTLKKSISNAKRIEETGFGYQMDLMNYTVEELKDKINKILSDKSLIEKTKKVGERIRKDNSIEKAVKFFYESLEKNLK", "length": 479, "molWeight": 56435, "crc64": "74ABCFC9CB4AC451", "md5": "6D6A0913F57948676BF601B0D5D55DBD"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI003247168E"}, "cluster_size": 2, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAA9YHV5", "uniProtkbId": "A0AAA9YHV5_HUMAN", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518665.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518665.1"}], "value": "Ubiquitin conjugating enzyme E2 I"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518665.1"}], "value": "UBE2I"}}], "features": [{"type": "Region", "location": {"start": {"value": 60, "modifier": "EXACT"}, "end": {"value": 84, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAA9YHV5"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAA9YHV5"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518665.1"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518665.1"}]}, {"referenceNumber": 3, "citation": {"id": "15616553", "citationType": "journal article", "authors": ["Martin J.", "Han C.", "Gordon L.A.", "Terry A.", "Prabhakar S.", "She X.", "Xie G.", "Hellsten U.", "Chan Y.M.", "Altherr M.", "Couronne O.", "Aerts A.", "Bajorek E.", "Black S.", "Blumer H.", "Branscomb E.", "Brown N.C.", "Bruno W.J.", "Buckingham J.M.", "Callen D.F.", "Campbell C.S.", "Campbell M.L.", "Campbell E.W.", "Caoile C.", "Challacombe J.F.", "Chasteen L.A.", "Chertkov O.", "Chi H.C.", "Christensen M.", "Clark L.M.", "Cohn J.D.", "Denys M.", "Detter J.C.", "Dickson M.", "Dimitrijevic-Bussod M.", "Escobar J.", "Fawcett J.J.", "Flowers D.", "Fotopulos D.", "Glavina T.", "Gomez M.", "Gonzales E.", "Goodstein D.", "Goodwin L.A.", "Grady D.L.", "Grigoriev I.", "Groza M.", "Hammon N.", "Hawkins T.", "Haydu L.", "Hildebrand C.E.", "Huang W.", "Israni S.", "Jett J.", "Jewett P.B.", "Kadner K.", "Kimball H.", "Kobayashi A.", "Krawczyk M.C.", "Leyba T.", "Longmire J.L.", "Lopez F.", "Lou Y.", "Lowry S.", "Ludeman T.", "Manohar C.F.", "Mark G.A.", "McMurray K.L.", "Meincke L.J.", "Morgan J.", "Moyzis R.K.", "Mundt M.O.", "Munk A.C.", "Nandkeshwar R.D.", "Pitluck S.", "Pollard M.", "Predki P.", "Parson-Quintana B.", "Ramirez L.", "Rash S.", "Retterer J.", "Ricke D.O.", "Robinson D.L.", "Rodriguez A.", "Salamov A.", "Saunders E.H.", "Scott D.", "Shough T.", "Stallings R.L.", "Stalvey M.", "Sutherland R.D.", "Tapia R.", "Tesmer J.G.", "Thayer N.", "Thompson L.S.", "Tice H.", "Torney D.C.", "Tran-Gyamfi M.", "Tsai M.", "Ulanovsky L.E.", "Ustaszewska A.", "Vo N.", "White P.S.", "Williams A.L.", "Wills P.L.", "Wu J.R.", "Wu K.", "Yang J.", "Dejong P.", "Bruce D.", "Doggett N.A.", "Deaven L.", "Schmutz J.", "Grimwood J.", "Richardson P.", "Rokhsar D.S.", "Eichler E.E.", "Gilna P.", "Lucas S.M.", "Myers R.M.", "Rubin E.M.", "Pennacchio L.A."], "citationCrossReferences": [{"database": "PubMed", "id": "15616553"}, {"database": "DOI", "id": "10.1038/nature03187"}], "title": "The sequence and analysis of duplication-rich human chromosome 16.", "publicationDate": "2004", "journal": "Nature", "firstPage": "988", "lastPage": "994", "volume": "432"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518665.1"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518665.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC120498", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AL031714", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000678584.2", "properties": [{"key": "ProteinId", "value": "ENSP00000518665.1"}, {"key": "GeneId", "value": "ENSG00000103275.22"}]}, {"database": "Ensembl", "id": "ENST00000711335.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518699.1"}, {"key": "GeneId", "value": "ENSG00000103275.22"}]}, {"database": "Ensembl", "id": "ENST00000711337.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518701.1"}, {"key": "GeneId", "value": "ENSG00000103275.22"}]}, {"database": "Ensembl", "id": "ENST00000711339.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518703.1"}, {"key": "GeneId", "value": "ENSG00000103275.22"}]}, {"database": "Ensembl", "id": "ENST00000711341.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518705.1"}, {"key": "GeneId", "value": "ENSG00000103275.22"}]}, {"database": "Ensembl", "id": "ENST00000711347.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518710.1"}, {"key": "GeneId", "value": "ENSG00000103275.22"}]}, {"database": "Ensembl", "id": "ENST00000711349.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518712.1"}, {"key": "GeneId", "value": "ENSG00000103275.22"}]}, {"database": "Ensembl", "id": "ENST00000711351.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518714.1"}, {"key": "GeneId", "value": "ENSG00000103275.22"}]}, {"database": "Ensembl", "id": "ENST00000713922.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518666.1"}, {"key": "GeneId", "value": "ENSG00000103275.22"}]}, {"database": "HGNC", "id": "HGNC:12485", "properties": [{"key": "GeneName", "value": "UBE2I"}]}, {"database": "OpenTargets", "id": "ENSG00000103275", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00550000075088", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 16"}]}, {"database": "Gene3D", "id": "3.10.110.10", "properties": [{"key": "EntryName", "value": "Ubiquitin Conjugating Enzyme"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR016135", "properties": [{"key": "EntryName", "value": "UBQ-conjugating_enzyme/RWD"}]}, {"database": "SUPFAM", "id": "SSF54495", "properties": [{"key": "EntryName", "value": "UBC-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGVWLRSRELGLQESHPGLKPSTGEPPGAQGLAAAT", "length": 84, "molWeight": 9050, "crc64": "E18907A52ADAA57F", "md5": "EAC362E753289241F46861736103F7AA"}, "extraAttributes": {"countByFeatureType": {"Region": 1}, "uniParcId": "UPI002B503BF2"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MMB3", "uniProtkbId": "A0AA96MMB3_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50036.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50036.1"}], "value": "Sulfotransferase-like protein"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005771"}], "value": "Belongs to the sulfotransferase 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 43, "modifier": "EXACT"}, "end": {"value": 286, "modifier": "EXACT"}}, "description": "Sulfotransferase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00685"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50036.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460113", "properties": [{"key": "ProteinId", "value": "WNS50036.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008146", "properties": [{"key": "GoTerm", "value": "F:sulfotransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR000863", "properties": [{"key": "EntryName", "value": "Sulfotransferase_dom"}]}, {"database": "PANTHER", "id": "PTHR11783", "properties": [{"key": "EntryName", "value": "SULFOTRANSFERASE SULT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00685", "properties": [{"key": "EntryName", "value": "Sulfotransfer_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAGINQEQSAEDGIYCDVIDGILMPPFFKQKRSEAYKAWTVLPDDIYITSFPKSGTTWTQHVVKLIKNNGKDDGVNTDKAMPWMEEAHPDEFKEMQSPRMFKTHMPYNLMFGGAPATSPSKFIYLARNPKDVSVSLYHHAKCFKLSDTEVAFPFSWDLFFEAFMTGQNHYGSWYDHVLPWWENKDAENILFLKYEDRKKNPRQAVEKIATFLSYNLDPDVLDSITQQSTFEAMKKNPATNWSWNKEKYTAEFVMMRKGVIGDWKNYYTPEQSKRMDEELKKQFPGTGLEFKFEEN", "length": 295, "molWeight": 34487, "crc64": "87BD529B4B20F522", "md5": "77F4A43D01FC4F406891932AD0EA9BA4"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI002B287D9C"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFF6", "uniProtkbId": "A0AAU7VFF6_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67474.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67474.1"}], "value": "Nanos-like protein 2"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67474.1"}], "value": "nanos2"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00855"}], "value": "Belongs to the nanos family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 280, "modifier": "EXACT"}, "end": {"value": 334, "modifier": "EXACT"}}, "description": "Nanos-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51522"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00855"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022845"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00855"}], "id": "KW-0810", "category": "Biological process", "name": "Translation regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00855"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67474.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67474.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750679", "properties": [{"key": "ProteinId", "value": "XBW67474.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006417", "properties": [{"key": "GoTerm", "value": "P:regulation of translation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "Gene3D", "id": "2.160.20.20", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "4.10.60.30", "properties": [{"key": "EntryName", "value": "Nanos, RNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR012332", "properties": [{"key": "EntryName", "value": "Autotransporter_pectin_lyase_C"}]}, {"database": "InterPro", "id": "IPR008705", "properties": [{"key": "EntryName", "value": "Nanos/Xcar2"}]}, {"database": "InterPro", "id": "IPR038129", "properties": [{"key": "EntryName", "value": "Nanos_sf"}]}, {"database": "InterPro", "id": "IPR024161", "properties": [{"key": "EntryName", "value": "Znf_nanos-typ"}]}, {"database": "PANTHER", "id": "PTHR12887", "properties": [{"key": "EntryName", "value": "NANOS PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF05741", "properties": [{"key": "EntryName", "value": "zf-nanos"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51522", "properties": [{"key": "EntryName", "value": "ZF_NANOS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRVKHLISAFYVPRYEEELKRLFRGSQSGHSTPDSGGTRSVWSRESPVAVASLEELEQILQDIRTSRHSLVAQDESASFVRPSYGSVVKSNSSIQLSNGTVLTSSGSVLPSNDSVQMSNSSVLSSNGSVQMSNGAVQMSNGSVQMSNGSFLMSNGSVPIRNGSLLMSNCSIPMSNCSLLMSNCSTHSSRSQSPALGSTETTRNFSGYAHVLASTVAKELINKAKLIDILRDREHLQRASGSAKRDALECLGAIGARNKSGGASSSGGSGKKLGKIVSANVCVFCRNNQEQEEVYASHSLKDSEGNVTCPVLYIYTCPTCGASGKRAHTIKYCPYGAGPVARALVKSTGAKL", "length": 351, "molWeight": 37147, "crc64": "F52BF198604567CC", "md5": "266B92ADE58CD9D4EE9D117D2A25D255"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D3342C"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEF4", "uniProtkbId": "A0AB38ZEF4_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00903.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00903.1"}], "value": "Venom peptide Es2a"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044208110"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00903.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-RUDT4T1F4QC9", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI00903.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP516298", "properties": [{"key": "ProteinId", "value": "WXI00903.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MRFFIIFTFLAMFITATLAAPVAEEIDLFKLMPQGGSRGIAPLIKICLPGQELNDKNECV", "length": 60, "molWeight": 6645, "crc64": "8D5F84CC22A6F824", "md5": "611C260BE774BFC05B2425CD5C322D8F"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BDE57"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEH3", "uniProtkbId": "A0AB38ZEH3_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02688.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02688.1"}], "value": "Venom S1 protease with CUB domain 1"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 696, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044210651"}, {"type": "Domain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 128, "modifier": "EXACT"}}, "description": "CUB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS01180"}]}, {"type": "Domain", "location": {"start": {"value": 452, "modifier": "EXACT"}, "end": {"value": 684, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}, {"type": "Region", "location": {"start": {"value": 248, "modifier": "EXACT"}, "end": {"value": 440, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 253, "modifier": "EXACT"}, "end": {"value": 399, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 405, "modifier": "EXACT"}, "end": {"value": 428, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 75, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02688.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02688.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517438", "properties": [{"key": "ProteinId", "value": "WXI02688.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00041", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00190", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.290", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000859", "properties": [{"key": "EntryName", "value": "CUB_dom"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001314", "properties": [{"key": "EntryName", "value": "Peptidase_S1A"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR018114", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24252", "properties": [{"key": "EntryName", "value": "ACROSIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24252:SF7", "properties": [{"key": "EntryName", "value": "HYALIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00431", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00722", "properties": [{"key": "EntryName", "value": "CHYMOTRYPSIN"}]}, {"database": "SMART", "id": "SM00042", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00020", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01180", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00134", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIRLILLAVAVAAAPPLVDYHVKLKPGEVFGYLRNPEYPGAYESDQPIVWKFESDPDSKIQIKCDDFRLAESENCKAVQVEVITKESRQSYCGQYEAFKVISAENKLIFKLKGDGLAQAVFSCYVKSTQAPPAEEVDVQLNQVFHFGTPEEPTPHFDKVWHLTAEKHFQVDLSCDVNLLEMNPCHGDVLTIDIGDGPEEYCGYVKKLLFSKGKRATVRLELDHIGNGRVHCVAQAVKKVMKPGIKQVDGDITDVNKDKEGKEIKDENEKEGKDQENKEQEVKDGDDKETNDQVNKEQEVKDTDQENKEQEVKDTDQENKEQEVKDTKDQDNKEQEVKDTKDEENKEQEVKDTKDEENKEQEVKDTKDEENKEQEVNEVKDAEDKESTDQENKEPEVKEVTDEEVKENLDLTDIKPGVEARNAVEDSSEHGGPPGKRGTTCRCGWANKPKGRIIRGREAAANEFPWMVGLRAHFGNKFARCGGSIVTHRHVITAAHCLIDLQGDRRPVKTENLYVIVGAHNLDMFSPKRSYREYQAEEHFIRPEFPRFLTHDFAIIVVKGHIEFNEFIGPICLSPVSIYEANKLITIMGWGQTESSRGSSKLLKANTKIIDKNWCRIKEWEVCTYAHQSATCSGDSGGPLVSLDKDTNRYFQVSLVSYGHPDCVSSPSVSTDVAYFYPWLLQKIKATYPEETPCIKV", "length": 696, "molWeight": 78908, "crc64": "7545D2DFD8DD6D08", "md5": "E4195A4703C93DF1542C44660D34A09C"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2, "Region": 1, "Compositional bias": 2, "Disulfide bond": 1}, "uniParcId": "UPI00388C12FE"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QK05", "uniProtkbId": "A0AAU0QK05_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56502.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56502.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 76, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 127, "modifier": "EXACT"}, "end": {"value": 154, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 208, "modifier": "EXACT"}, "end": {"value": 230, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 242, "modifier": "EXACT"}, "end": {"value": 260, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 261, "modifier": "EXACT"}, "end": {"value": 261, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56502.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56502.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56502.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56502.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970395", "properties": [{"key": "ProteinId", "value": "WPO56502.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MEALSYVTQKNLTEKQRSDRAMFVMSHPILFAYIGTVEILKNNIERLLHELVVELKRTYNDLHVEASMIKKSKQHCASFSALFMIAILFYGYEATVQVVRGGGTFTTVITCWPDVEDTSLLAMVARVIWYLLWWLFMIRVCAVYIDVISTIVALSHQFKNCQKYFLSLNLIFDEDLDENEKEMKYLESFKLGIQMHAKTLWCTKECQAAYSLIFSFQIMTLVSVLAQLMSQMVESGRSLENVLSIVAAGSTTLLSTGFFMC", "length": 261, "molWeight": 29894, "crc64": "08E661E5EB173B02", "md5": "E9CACC9A1DB144F569ACB5C7A54F67EC"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 4, "Non-terminal residue": 1}, "uniParcId": "UPI00308A65D7"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHK4", "uniProtkbId": "A0AAN0LHK4_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34081.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34081.1"}], "value": "Ligated ion channel binding I - glutamate"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 422, "modifier": "EXACT"}, "end": {"value": 439, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 451, "modifier": "EXACT"}, "end": {"value": 473, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 738, "modifier": "EXACT"}, "end": {"value": 755, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 767, "modifier": "EXACT"}, "end": {"value": 789, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1269, "modifier": "EXACT"}, "end": {"value": 1293, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34081.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155007", "properties": [{"key": "ProteinId", "value": "WRW34081.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MKALNLSAVICSLPVTIQKSENPSQNFQENNDCSMGHKFKNNSFNGLYKDLIDQDADFILFFAKHELLYEDFFYSSINILEEIIFFYFFHVKSNNLSILSNIKKISYDIRFLNVLLIEFDKTNYLLTLEDLSLSSYYNPIIISKDIEDLFENSKLISKKVIWNKFKKTTLHPSCSYDATFTGQLECLNFMKNNNLALITEDKEIPFFENVYCADNNKLINKNDNYVWVYGKPFLTYSNYFPINKKIKLYKRKIFDKHVSSLFNMGRFIKLNIDVAKNLKVLFISKNSEYLAMQALNLTTVICSLPVTIQRSKDENKNFDGILASVFNDFFPRKKFNLNSYENTDCLLGHKFENNGTFNGMYDDLLKQNLDFILFCAKHQLLYDEFSYSPIIYDEKIVYFYFFLIKSNSLSILSNMKKVSSDILVLVLIVYIINLSFELIKKKSYNKVYKLLSTVFISFFLTNYILGYLNVLLIEFDKTNFIPTLEDLSLSSYYNPIIYSQDIEDLFEKSNEKTKKIIWQKYKKTNREPCNYDADFEEELKCLQYLKVNKIAIIFEEGEIPFFEPVYCSDDNHLVNRNDNYVWIYGEPFLRVSNFYPYNKKISFHKRKILDDHLVLQFDTGLSLKQGMNIKKSIKDQFRSKNSECILTKKNEFINSYENTDCLLGHKFENNGTYNGMYNDLLKQDLDFIMFSAKHQLLYDDFLYSPIIYDEKIVYFYFFLIKSNNLSIMSNIKKISSEILVLATIVYLTNLSFDLVKKVSYNKVYKLLSTVFISFFLINYILGSLNVLLIELDKTNYISSLKDLALSSYYSPIIYTEDTENLFENSDEKVKKKIWKKYKNIKRDTSCNYDADFEEEIRCLQSIKSNKLAMIIEEGEIPFFEPVYCAENNRLIDKNDNYVWIYSQPFLQISNYFPFNKKISFLKRKKLYGHLNLLFNMGLLIKQYRDLNKSIKDQFKSRNSECILTKKRELFDKNLFFTQLLPVVLQKTKDENLNFGGILAPVYNSLFPRKKLFFYTHENTDCLLGHRFDNNGTYNGMYNDLLEKNLDLIFFCAKHQLLYDDFLYRYLNVLLIEFDKTNYVPTLKDLSSSSFYKPIIYSQDIQVLFKNSEETTKKLIWKKFKKIKLDPSCKYDADFEDELKCLKFMKTNKFAIILEEGEIPFFEPVYCANKNKFLEKHDKIAWVYGKPFSAFSNFFPYNKNLNSHKRKILDDHMNFLFNMGLFIKQNIDIHKNIKNQFKTKNSECVLRKKEELLDKSYFFTQLVFDNYQSLFIIFIFIQSLTILLFFLDFLLFFIKKNENNFDFISKM", "length": 1306, "molWeight": 154982, "crc64": "514E4EAAD5402AAD", "md5": "B51D0D4D356A311F73703FC2E66DFF4A"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 5}, "uniParcId": "UPI00325200BD"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8MKE3", "uniProtkbId": "A0AAU8MKE3_9CRYP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Chroomonas placoidea", "taxonId": 173977, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCO00664.1"}], "lineage": ["Eukaryota", "Cryptophyceae", "Pyrenomonadales", "Chroomonadaceae", "Chroomonas"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCO00664.1"}], "value": "Chloroplast PsbM"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCO00664.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCO00664.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022531"}], "id": "KW-0602", "category": "Biological process", "name": "Photosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023276"}], "id": "KW-0604", "category": "Cellular component", "name": "Photosystem II"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022469"}], "id": "KW-0674", "category": "Cellular component", "name": "Reaction center"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AMO3UKG3JTHS3", "citationType": "submission", "authors": ["Zhao L."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCO00664.1"}], "value": "T11", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCO00664.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP870015", "properties": [{"key": "ProteinId", "value": "XCO00664.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "SMR", "id": "A0AAU8MKE3", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0009523", "properties": [{"key": "GoTerm", "value": "C:photosystem II"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0019684", "properties": [{"key": "GoTerm", "value": "P:photosynthesis, light reaction"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR007826", "properties": [{"key": "EntryName", "value": "PSII_PsbM"}]}, {"database": "InterPro", "id": "IPR037269", "properties": [{"key": "EntryName", "value": "PSII_PsbM_sf"}]}, {"database": "NCBIfam", "id": "TIGR03038", "properties": [{"key": "EntryName", "value": "PS_II_psbM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF05151", "properties": [{"key": "EntryName", "value": "PsbM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF161033", "properties": [{"key": "EntryName", "value": "Photosystem II reaction center protein M, PsbM"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNVSVAAYLAVLLGTFVPVVFLVTLYIQSESRKAGSS", "length": 37, "molWeight": 3932, "crc64": "0C54442E320C6D56", "md5": "EB72E4F928AFA104BE2D743CA19902BB"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0032E9396D"}, "cluster_size": 1, "family": "Chroomonadaceae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXB7", "uniProtkbId": "CGLR_NICVS", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Nicrophorus vespilloides", "commonName": "Boreal carrion beetle", "taxonId": 110193, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Coleoptera", "Polyphaga", "Staphyliniformia", "Silphidae", "Nicrophorinae", "Nicrophorus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Cyclic GMP-AMP synthase-like receptor"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37379839"}], "value": "Nves-cGLR"}], "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}], "value": "2.7.7.86"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37379839"}], "value": "cGLR"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}], "value": "Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:37379839). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:37379839). Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor (PubMed:37379839)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "GTP + ATP = 2',3'-cGAMP + 2 diphosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:42064"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:33019"}, {"database": "ChEBI", "id": "CHEBI:37565"}, {"database": "ChEBI", "id": "CHEBI:143093"}], "ecNumber": "2.7.7.86", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:42065"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}]}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "GTP + ATP = pppGp(2'-5')A + diphosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:23748"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:33019"}, {"database": "ChEBI", "id": "CHEBI:37565"}, {"database": "ChEBI", "id": "CHEBI:78318"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:23749"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}]}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "pppGp(2'-5')A = 2',3'-cGAMP + diphosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:23924"}, {"database": "ChEBI", "id": "CHEBI:33019"}, {"database": "ChEBI", "id": "CHEBI:78318"}, {"database": "ChEBI", "id": "CHEBI:143093"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:23925"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}]}, {"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}, {"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the mab-21 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 353, "modifier": "EXACT"}}, "description": "Cyclic GMP-AMP synthase-like receptor", "featureId": "PRO_0000460022"}, {"type": "Binding site", "location": {"start": {"value": 60, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 72, "modifier": "EXACT"}, "end": {"value": 74, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 72, "modifier": "EXACT"}, "end": {"value": 72, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 74, "modifier": "EXACT"}, "end": {"value": 74, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 183, "modifier": "EXACT"}, "end": {"value": 183, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:37565"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "GTP", "id": "ChEBI:CHEBI:37565"}}, {"type": "Binding site", "location": {"start": {"value": 183, "modifier": "EXACT"}, "end": {"value": 183, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 245, "modifier": "EXACT"}, "end": {"value": 245, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 269, "modifier": "EXACT"}, "end": {"value": 269, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29035"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "ligand": {"name": "Mn(2+)", "id": "ChEBI:CHEBI:29035"}}, {"type": "Binding site", "location": {"start": {"value": 270, "modifier": "EXACT"}, "end": {"value": 270, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29035"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "ligand": {"name": "Mn(2+)", "id": "ChEBI:CHEBI:29035"}}], "keywords": [{"id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"id": "KW-0342", "category": "Ligand", "name": "GTP-binding"}, {"id": "KW-0391", "category": "Biological process", "name": "Immunity"}, {"id": "KW-0399", "category": "Biological process", "name": "Innate immunity"}, {"id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"id": "KW-0464", "category": "Ligand", "name": "Manganese"}, {"id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"id": "KW-0548", "category": "Molecular function", "name": "Nucleotidyltransferase"}, {"id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B6DCKT9L708DI", "citationType": "submission", "authors": ["Cunningham C.B.", "Li L.", "Wiberg R.A.", "Shelton J.M.", "Mckinney E.C.", "Parker D.J.", "Meagher R.B.", "Benowitz K.M.", "Roy-Zokan E.M.", "Ritchie M.G.", "Brown S.J.", "Schmitz R.B.", "Moore A.J."], "title": "The Nicrophorus vespilloides genome and methylome, a beetle with complex social behavior.", "publicationDate": "AUG-2015", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}, {"referenceNumber": 2, "citation": {"id": "37379839", "citationType": "journal article", "authors": ["Li Y.", "Slavik K.M.", "Toyoda H.C.", "Morehouse B.R.", "de Oliveira Mann C.C.", "Elek A.", "Levy S.", "Wang Z.", "Mears K.S.", "Liu J.", "Kashin D.", "Guo X.", "Mass T.", "Sebe-Pedros A.", "Schwede F.", "Kranzusch P.J."], "citationCrossReferences": [{"database": "PubMed", "id": "37379839"}, {"database": "DOI", "id": "10.1016/j.cell.2023.05.038"}], "title": "cGLRs are a diverse family of pattern recognition receptors in innate immunity.", "publicationDate": "2023", "journal": "Cell", "firstPage": "3261", "lastPage": "3276", "volume": "186"}, "referencePositions": ["FUNCTION", "CATALYTIC ACTIVITY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LJCH01000001", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "P0DXB7", "properties": [{"key": "Description", "value": "-"}]}, {"database": "KEGG", "id": "nvl:108568334", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000695000", "properties": [{"key": "Component", "value": "Unplaced"}]}, {"database": "GO", "id": "GO:0061501", "properties": [{"key": "GoTerm", "value": "F:2',3'-cyclic GMP-AMP synthase activity"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "37379839"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003690", "properties": [{"key": "GoTerm", "value": "F:double-stranded DNA binding"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "37379839"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0045087", "properties": [{"key": "GoTerm", "value": "P:innate immune response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.10.1410.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.460.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR046903", "properties": [{"key": "EntryName", "value": "Mab-21-like_nuc_Trfase"}]}, {"database": "InterPro", "id": "IPR046906", "properties": [{"key": "EntryName", "value": "Mab-21_HhH/H2TH-like"}]}, {"database": "InterPro", "id": "IPR024810", "properties": [{"key": "EntryName", "value": "MAB21L/cGLR"}]}, {"database": "PANTHER", "id": "PTHR10656", "properties": [{"key": "EntryName", "value": "CELL FATE DETERMINING PROTEIN MAB21-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10656:SF42", "properties": [{"key": "EntryName", "value": "CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03281", "properties": [{"key": "EntryName", "value": "Mab-21"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF20266", "properties": [{"key": "EntryName", "value": "Mab-21_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01265", "properties": [{"key": "EntryName", "value": "Mab-21"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEYSWLENKLQEINRKCIQINNKKSNNDSLNMIIGKLIDVMKDTSVLFKTLYERIIFNGSYYNNLKISKADEYDLDLILVLPVALETVLMLTPEAGYVDVKIDISKIKKLAYYRDILTPLEKLCENGIFSSLKIHSWFEGLVQKSLNIINASKYFPQYKLDMYKSGPAVTLTVHTPFSSYDMDLVPCLKLDKSLYPKGYKKQNCNHIYAVSKPNKDKEWRLSFIEQELSILRDNGHVKPAIRLLKFLRDQRDHKLIKSYFIVTVAMWDLETTNFNGKSLSFAFMTLLESLYKHICERKIPFYWNPNLNLLNKCHRDYLFNLENQLLNILKKLRSSNSNPNVLNEVFNFDIQES", "length": 353, "molWeight": 41388, "crc64": "D37E20EDDEAFB5C8", "md5": "01BCBA88125580B40D85D8B95D2C17EA"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 3, "COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Binding site": 9}, "uniParcId": "UPI00083C4CD2"}, "cluster_size": 2, "family": "Silphidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MKD6", "uniProtkbId": "A0AA96MKD6_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50032.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50032.1"}], "value": "Peroxidase-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 972, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041648623"}, {"type": "Region", "location": {"start": {"value": 196, "modifier": "EXACT"}, "end": {"value": 234, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 866, "modifier": "EXACT"}, "end": {"value": 885, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 903, "modifier": "EXACT"}, "end": {"value": 958, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 872, "modifier": "EXACT"}, "end": {"value": 881, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 908, "modifier": "EXACT"}, "end": {"value": 926, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 496, "modifier": "EXACT"}, "end": {"value": 496, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:60344"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR619791-2"}], "ligand": {"name": "heme b", "id": "ChEBI:CHEBI:60344"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR619791-2"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR619791-2"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR619791-2"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50032.1"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50032.1"}], "id": "KW-0575", "category": "Molecular function", "name": "Peroxidase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50032.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460109", "properties": [{"key": "ProteinId", "value": "WNS50032.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004601", "properties": [{"key": "GoTerm", "value": "F:peroxidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006979", "properties": [{"key": "GoTerm", "value": "P:response to oxidative stress"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd09823", "properties": [{"key": "EntryName", "value": "peroxinectin_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.640.10:FF:000003", "properties": [{"key": "EntryName", "value": "chorion peroxidase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.640.10", "properties": [{"key": "EntryName", "value": "Haem peroxidase domain superfamily, animal type"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR019791", "properties": [{"key": "EntryName", "value": "Haem_peroxidase_animal"}]}, {"database": "InterPro", "id": "IPR010255", "properties": [{"key": "EntryName", "value": "Haem_peroxidase_sf"}]}, {"database": "InterPro", "id": "IPR037120", "properties": [{"key": "EntryName", "value": "Haem_peroxidase_sf_animal"}]}, {"database": "PANTHER", "id": "PTHR11475:SF4", "properties": [{"key": "EntryName", "value": "CHORION PEROXIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11475", "properties": [{"key": "EntryName", "value": "OXIDASE/PEROXIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03098", "properties": [{"key": "EntryName", "value": "An_peroxidase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00457", "properties": [{"key": "EntryName", "value": "ANPEROXIDASE"}]}, {"database": "SUPFAM", "id": "SSF48113", "properties": [{"key": "EntryName", "value": "Heme-dependent peroxidases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50292", "properties": [{"key": "EntryName", "value": "PEROXIDASE_3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGVWQAAAVFCLLVCVWSLAGADNVLIQEMASLPSADRARVIKAAIASVNEQVKISSEVLGNGRIRTQNRLKDPAIDAQGLSRVRLEKTVRKAEADLIRLRYKDALQSSDRSVRVEALARVAFHRLGSLLSRSEIRMIQEETSQCSPPAQPRCDSFLKQRSIDGTCNNLARPLQGAAGQNFRRLIAARYEDGISQPRGFLQSKGNDLAGRDEFSPPNPSPREVSRTVLRPQPEDDPIHSHMIMQWGQFLDHDLDLAPEFGEHDCPPESCIATEKCFPIRKVSDDPSFTSLPCLFFGRSIPSCNPADGEFPAREQFNAITHYIDASNVYGSSQGVARELRELQGGRLKTGPPHTPGAKPSLPLLSREELEKIEREGTFLTLCPEPLEKCYVAGDVRVNEHLALTAMHTIWLREHNRIVAQLSRLQPGQTDEQLYQTARSVVGGEMQAIIYQEYLPEVLGSTVVEKLILSPALTGGYDSSVDPSVPNSYAAAAFRYGHSLIRPEFARLDEKNRPLPAGPLNLLDSFFDPSQYNTSLGTDPVLRGLLAEAARRADEFLTPVLTTQLFASGSFDGRDLGALNINRGRDHGLPPYLVWREFCVRYWKEQGLQVRPQFRSELTQLELTRVYGSLDSVDLFAGAMAEEPFVHPANGEKSIIGPTFTCIFAINYRAMAQGDRFFYQFPTYSPNQVAQLKKTSLSRVICDNSDGIAHIQPNAFLRASKTNGPVYCSSLPSLDLSAFATIGCEKYIKLSLWLPAYTWLRGIVMMDKPTYDSHTSQFFSLSRGTQCVKISCPVKYSKVIAYIARGQPIRPSVTPGLAASLKFNGKYLAGVVPLAKMAATNGIYDSAVQCRSGRVVAVRYGHPAVSHHFKTTKQEAPQTTDGQVPTGISDEESILRLVESTTIPVQEPVDAYDDDDAVDGSEYGEYEDSSSNQPSAAVSEEGEKDSASRADAGLQEAAGATLDQDLEDALSALQ", "length": 972, "molWeight": 106943, "crc64": "E6EE7ACB317CFFFB", "md5": "ADAAC10BF9EFA93E062D83DEE55B3D98"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 3, "Compositional bias": 2, "Binding site": 1}, "uniParcId": "UPI002B2E09A0"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LM77", "uniProtkbId": "A0AAN0LM77_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34083.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34083.1"}], "value": "Ligated ion channel binding I - glutamate"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 129, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 154, "modifier": "EXACT"}, "end": {"value": 172, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34083.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155009", "properties": [{"key": "ProteinId", "value": "WRW34083.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVLSLKTVICSLSVTLRKSKSNKHNFEGILADIFESFFPKKNFNVTLFETNNCLLGRQLPNGSFTGIYQEIINKNLDLGLFFAKDQLLNNHFFYSPVLCFEEILYFYFFEVKFNKMSILTNLRNINFSLIFLTLMVILSRLLFRFIIKNVYQKLYKLLLTIFISFFLTNYILGSLNVLMIEFDKTNFLSTSKDLSLTSYYKIIFKSDDLREYFKLSYDVNNRNILTKSEKSNLINKPKICTHMKSFDDILNCVQGMKEKKLVYILEDRYLAFFEPIYCSDAHQSLNKNKNLIWINSQKFATIANFLPYNRNIDIYKRKKIDNQLVDFISIFENN", "length": 334, "molWeight": 39520, "crc64": "D5769AB91EF3E223", "md5": "5F2C97DFF37B030CBC2EB21C2DB356C0"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2}, "uniParcId": "UPI00324B5D3E"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9TZ14", "uniProtkbId": "A0AAT9TZ14_9HEMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Eocanthecona furcellata", "taxonId": 696902, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83469.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Pentatomomorpha", "Pentatomoidea", "Pentatomidae", "Asopinae", "Eocanthecona"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83469.1"}], "value": "Odorant-binding protein 4"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83469.1"}], "value": "OBP4"}}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4EEV3RJ5PT5SU", "citationType": "submission", "authors": ["Pan Y.", "Chen W."], "publicationDate": "OCT-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83469.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP575948", "properties": [{"key": "ProteinId", "value": "WGJ83469.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRSFLTVTIAFSEQAKIVSNQAIPKTEAEKCFLECMYNGLNITRDGKFIELSAKGLAQHRFANSPDELTKANNMIETCTKEAVVKDANEKCAIGRLVRECFVKNGSKVINLIQVTYDNHLINNN", "length": 124, "molWeight": 13885, "crc64": "92BD42DC77D88FA0", "md5": "3464BF84986C56A9187E29DD0402C1B6"}, "extraAttributes": {"uniParcId": "UPI0035D3735C"}, "cluster_size": 1, "family": "Pentatomidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P894", "uniProtkbId": "A0AAF0P894_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenuipotamon panxiense", "taxonId": 2841827, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}], "value": "G-protein coupled receptor"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}], "value": "scaffold1802736"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004370"}], "value": "Membrane", "id": "SL-0162"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 64, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 98, "modifier": "EXACT"}, "end": {"value": 118, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 155, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}, {"type": "Region", "location": {"start": {"value": 192, "modifier": "EXACT"}, "end": {"value": 220, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 192, "modifier": "EXACT"}, "end": {"value": 203, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 205, "modifier": "EXACT"}, "end": {"value": 220, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 232, "modifier": "EXACT"}, "end": {"value": 232, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69289.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR517342", "properties": [{"key": "ProteinId", "value": "WMS69289.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0008528", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled peptide receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR019427", "properties": [{"key": "EntryName", "value": "7TM_GPCR_serpentine_rcpt_Srw"}]}, {"database": "InterPro", "id": "IPR053093", "properties": [{"key": "EntryName", "value": "GPCR-like"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR47760", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47760:SF1", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10324", "properties": [{"key": "EntryName", "value": "7TM_GPCR_Srw"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "RVPREAEDCQAPSFTPPDNQTWWVACLIHDTSNKGYFIVYVWIRQAVVTFLPIIAVVWLNLLTLRGFMRHTRMRRDMLNRRVSGQPSVMSNSREEKNLMGLLIAVISSFVITIVPSGIANAINSSTNTSELTFVIFSAVANNLEILNHTLNFYLYVLCSKPVRDTLQEYYNKHRTNIARRLEGFSSARKVKSETGDDRVDGEMRNSVTPISKSSTPRHSQQIYAISGTPLSS", "length": 232, "molWeight": 26269, "crc64": "B2916B6A510F5430", "md5": "1E23D09B1848C17F8EFC3B524F65FA24"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 2, "Domain": 1, "Region": 1, "Compositional bias": 2, "Non-terminal residue": 2}, "uniParcId": "UPI002B2DEAFE"}, "cluster_size": 11, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMM9", "uniProtkbId": "A0AAU0QMM9_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56475.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56475.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 46, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 123, "modifier": "EXACT"}, "end": {"value": 143, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 149, "modifier": "EXACT"}, "end": {"value": 168, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56475.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56475.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56475.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970368", "properties": [{"key": "ProteinId", "value": "WPO56475.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF44", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 13A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFTDDVIEPLLPFDGWYPFNKVNWYYIALIWESFMTSIVVCIYGFVSMTNSSFTLSLCMELKVLGYSIESIISENNRKNIVKGINKIETNNGIKNNLKNIIKRHQLLAQMASEFNDVTGDPMFLNYVFGSVFITLTIFTATVVDNLYNSLRYFFMFCSLLLEIFFQCLNGQLLSDHSETLTGSIYKADWTYADNDTKIILLILMSRTQKPFQYTANGFLVMNLESFSSVCSMSYQFFNLLYTMYYN", "length": 246, "molWeight": 28539, "crc64": "A834C941ED437FA6", "md5": "A7C4E548397862D81EE8817D6819A403"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 3}, "uniParcId": "UPI00308B8E5A"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTU4", "uniProtkbId": "A0AAT9UTU4_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41692.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41692.1"}], "value": "Cytochrome P450 3638J1 short isoform"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 34, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 317, "modifier": "EXACT"}, "end": {"value": 341, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41692.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117252", "properties": [{"key": "ProteinId", "value": "WIM41692.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MINFLTNSSFYALCKIASITTGMLLCMTIFYYILIHEWRVRKMMPNLKTFNSSPTLPVIGSLHHIAFNINKGATKLLQIFNHYKLPLVGWIVRSPFVAVGSYEDIQIVMNNSLERDFLGLLRKVATNSTLLLQGEQWQKSRHIATPAFSYGAMQQYIPVFNEYASFLVKKLQQFSNNNEAIEITNHVFSMNIDATIQNMTGYKLRSLETENTEVIKLLFKLLQMESMRFAFPPLFPEFMYKIYLFFSGKDKLYKKIHAISKKILKDKLNQYEMNKKREKNQDTHETDDQDSKSLINLLLKVHKIDATLTEKHIRDELIIMITLGYESISLTVCAMLLMLAMNPDIQVNNLKTETFTLSFNAYISTITFRQRYTTKL", "length": 376, "molWeight": 43705, "crc64": "B0311C7323325915", "md5": "C404D26D81C5752D01A6A2CFF9A24CDA"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 2}, "uniParcId": "UPI0035D28D03"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXC1", "uniProtkbId": "SRSP_HUMAN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "32440474"}], "value": "Splicing regulatory small protein"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "32440474"}], "value": "SRSP"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "32440474"}], "value": "Interacts with the splicing factor SRSF3 and increases its binding to specific exons within pre-mRNA, thereby regulating exon-inclusion during alternative splicing (PubMed:32440474). Does not directly bind pre-mRNA and could regulate a wider range of splicing factors through a similar mechanism (PubMed:32440474)"}], "commentType": "FUNCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "32440474"}], "value": "Interacts with SRSF3; increases SRSF3 binding to specific exons"}], "commentType": "SUBUNIT"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "32440474"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 130, "modifier": "EXACT"}}, "description": "Splicing regulatory small protein", "featureId": "PRO_0000459842"}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Mediates interaction with SRSF3", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "32440474"}]}, {"type": "Region", "location": {"start": {"value": 74, "modifier": "EXACT"}, "end": {"value": 130, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 10, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 77, "modifier": "EXACT"}, "end": {"value": 98, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 120, "modifier": "EXACT"}, "end": {"value": 130, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"id": "KW-0507", "category": "Biological process", "name": "mRNA processing"}, {"id": "KW-0508", "category": "Biological process", "name": "mRNA splicing"}, {"id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "15815621", "citationType": "journal article", "authors": ["Hillier L.W.", "Graves T.A.", "Fulton R.S.", "Fulton L.A.", "Pepin K.H.", "Minx P.", "Wagner-McPherson C.", "Layman D.", "Wylie K.", "Sekhon M.", "Becker M.C.", "Fewell G.A.", "Delehaunty K.D.", "Miner T.L.", "Nash W.E.", "Kremitzki C.", "Oddy L.", "Du H.", "Sun H.", "Bradshaw-Cordum H.", "Ali J.", "Carter J.", "Cordes M.", "Harris A.", "Isak A.", "van Brunt A.", "Nguyen C.", "Du F.", "Courtney L.", "Kalicki J.", "Ozersky P.", "Abbott S.", "Armstrong J.", "Belter E.A.", "Caruso L.", "Cedroni M.", "Cotton M.", "Davidson T.", "Desai A.", "Elliott G.", "Erb T.", "Fronick C.", "Gaige T.", "Haakenson W.", "Haglund K.", "Holmes A.", "Harkins R.", "Kim K.", "Kruchowski S.S.", "Strong C.M.", "Grewal N.", "Goyea E.", "Hou S.", "Levy A.", "Martinka S.", "Mead K.", "McLellan M.D.", "Meyer R.", "Randall-Maher J.", "Tomlinson C.", "Dauphin-Kohlberg S.", "Kozlowicz-Reilly A.", "Shah N.", "Swearengen-Shahid S.", "Snider J.", "Strong J.T.", "Thompson J.", "Yoakum M.", "Leonard S.", "Pearman C.", "Trani L.", "Radionenko M.", "Waligorski J.E.", "Wang C.", "Rock S.M.", "Tin-Wollam A.-M.", "Maupin R.", "Latreille P.", "Wendl M.C.", "Yang S.-P.", "Pohl C.", "Wallis J.W.", "Spieth J.", "Bieri T.A.", "Berkowicz N.", "Nelson J.O.", "Osborne J.", "Ding L.", "Meyer R.", "Sabo A.", "Shotland Y.", "Sinha P.", "Wohldmann P.E.", "Cook L.L.", "Hickenbotham M.T.", "Eldred J.", "Williams D.", "Jones T.A.", "She X.", "Ciccarelli F.D.", "Izaurralde E.", "Taylor J.", "Schmutz J.", "Myers R.M.", "Cox D.R.", "Huang X.", "McPherson J.D.", "Mardis E.R.", "Clifton S.W.", "Warren W.C.", "Chinwalla A.T.", "Eddy S.R.", "Marra M.A.", "Ovcharenko I.", "Furey T.S.", "Miller W.", "Eichler E.E.", "Bork P.", "Suyama M.", "Torrents D.", "Waterston R.H.", "Wilson R.K."], "citationCrossReferences": [{"database": "PubMed", "id": "15815621"}, {"database": "DOI", "id": "10.1038/nature03466"}], "title": "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.", "publicationDate": "2005", "journal": "Nature", "firstPage": "724", "lastPage": "731", "volume": "434"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}, {"referenceNumber": 2, "citation": {"id": "32440474", "citationType": "journal article", "authors": ["Meng N.", "Chen M.", "Chen D.", "Chen X.H.", "Wang J.Z.", "Zhu S.", "He Y.T.", "Zhang X.L.", "Lu R.X.", "Yan G.R."], "citationCrossReferences": [{"database": "PubMed", "id": "32440474"}, {"database": "DOI", "id": "10.1002/advs.201903233"}], "title": "Small protein hidden in lncRNA LOC90024 promotes 'cancerous' RNA splicing and tumorigenesis.", "publicationDate": "2020", "journal": "Adv. Sci.", "firstPage": "1903233", "lastPage": "1903233", "volume": "7"}, "referencePositions": ["IDENTIFICATION BY MASS SPECTROMETRY", "FUNCTION", "INTERACTION WITH SRSF3", "REGION"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AP001816", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Unplaced"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "32440474"}]}, {"database": "GO", "id": "GO:0036002", "properties": [{"key": "GoTerm", "value": "F:pre-mRNA binding"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "32440474"}]}, {"database": "GO", "id": "GO:0006397", "properties": [{"key": "GoTerm", "value": "P:mRNA processing"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0043484", "properties": [{"key": "GoTerm", "value": "P:regulation of RNA splicing"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "32440474"}]}, {"database": "GO", "id": "GO:0008380", "properties": [{"key": "GoTerm", "value": "P:RNA splicing"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MRTKPQRPRATRSYLGQPCGSPRRTEETGETWERVAFSLFTHTCTQPLAGTVDTHLPSLLLPVILHPLGAASAGRALEPKADPHTCPYGRKESRGEKVRRGRAKSNSGPNVPGPPAAPQSLKSGSPSTRR", "length": 130, "molWeight": 14030, "crc64": "05A42ACA5EDAE714", "md5": "C55A3167A9AA9BABB4618612142B44D0"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBUNIT": 1, "SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Chain": 1, "Region": 3, "Compositional bias": 3}, "uniParcId": "UPI0000140F92"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QL41", "uniProtkbId": "A0AAU0QL41_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56522.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56522.1"}], "value": "Ionotropic receptor"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 207, "modifier": "EXACT"}, "end": {"value": 207, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56522.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56522.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56522.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56522.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970322", "properties": [{"key": "ProteinId", "value": "WPO56522.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MAIVTTEVMTTLSEIARNLLMSHTLAQWLYVISDTDLNNGNLSSLINSLYEGENVAFMYNVTDNSPDCKNGIMCYCQEMLSAFVSALDAAVQDELDVAAQVSDEEWEAIRPTKLQRRSMLLKHMQQFIATKSRCGNCSTWRALAADTWGATYRTFTDTEFLGDTGNATTAGVIEHVDLLHVGYWRPIDALRFDEVLFPHVEHGFRGK", "length": 207, "molWeight": 23239, "crc64": "B9F56DD3A9A1FCC4", "md5": "76AE9E2BE00C14D030AB1B4C6DC32652"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0030931E1A"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA95ZCX9", "uniProtkbId": "A0AA95ZCX9_THRPL", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Thrips palmi", "commonName": "Melon thrips", "taxonId": 161013, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96476.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Thysanoptera", "Terebrantia", "Thripoidea", "Thripidae", "Thrips"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96476.1"}], "value": "Vitellogenin"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 2, "modifier": "EXACT"}, "end": {"value": 125, "modifier": "EXACT"}}, "description": "Vitellinogen open beta-sheet", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF09172"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96476.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 126, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96476.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-A8QMHI7B7G5F", "citationType": "submission", "authors": ["Shiksha B.", "Amalendu G."], "publicationDate": "JUL-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96476.1"}], "value": "AG-78", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96476.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR358943", "properties": [{"key": "ProteinId", "value": "WNH96476.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005319", "properties": [{"key": "GoTerm", "value": "F:lipid transporter activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "2.20.80.10", "properties": [{"key": "EntryName", "value": "Lipovitellin-phosvitin complex, chain A, domain 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR015819", "properties": [{"key": "EntryName", "value": "Lipid_transp_b-sht_shell"}]}, {"database": "InterPro", "id": "IPR015255", "properties": [{"key": "EntryName", "value": "Vitellinogen_open_b-sht"}]}, {"database": "InterPro", "id": "IPR050733", "properties": [{"key": "EntryName", "value": "Vitellogenin/Apolipophorin"}]}, {"database": "PANTHER", "id": "PTHR23345:SF15", "properties": [{"key": "EntryName", "value": "VITELLOGENIN 1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23345", "properties": [{"key": "EntryName", "value": "VITELLOGENIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF09172", "properties": [{"key": "EntryName", "value": "Vit_open_b-sht"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56968", "properties": [{"key": "EntryName", "value": "Lipovitellin-phosvitin complex, beta-sheet shell regions"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "FLINVLSQQRFFTLDNHTVEQIPQYLKHAANTLRSGENFNYTKLYNRYSLTMGIPTSMGLPLVYTLKAPTMVTVGGEARVRTQPDLANGPKDAAYVPNTVNASADVHFTYATRTEAKMGFITPFDH", "length": 126, "molWeight": 14101, "crc64": "4D9DFBECC9738B81", "md5": "EF0370C919951DEE8DBD12F8666A3F2B"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2BCE1F"}, "cluster_size": 1, "family": "Thripidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7J8F7", "uniProtkbId": "A0AAU7J8F7_LOCMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Locusta migratoria", "commonName": "Migratory locust", "taxonId": 7004, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89717.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Polyneoptera", "Orthoptera", "Caelifera", "Acrididea", "Acridomorpha", "Acridoidea", "Acrididae", "Oedipodinae", "Locusta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89717.1"}], "value": "Tudor domain-containing protein Tdr14"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 74, "modifier": "EXACT"}}, "description": "Ubiquitin-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50053"}]}, {"type": "Region", "location": {"start": {"value": 148, "modifier": "EXACT"}, "end": {"value": 175, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 272, "modifier": "EXACT"}, "end": {"value": 365, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 380, "modifier": "EXACT"}, "end": {"value": 429, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 272, "modifier": "EXACT"}, "end": {"value": 299, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 326, "modifier": "EXACT"}, "end": {"value": 335, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 429, "modifier": "EXACT"}, "end": {"value": 429, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89717.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3S1R4NEJO2BB6", "citationType": "submission", "authors": ["Deng S.", "Wang J.", "Ma E.", "Zhang J.", "Xing S."], "title": "Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89717.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR912216", "properties": [{"key": "ProteinId", "value": "XBN89717.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.20.90", "properties": [{"key": "EntryName", "value": "Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000626", "properties": [{"key": "EntryName", "value": "Ubiquitin-like_dom"}]}, {"database": "InterPro", "id": "IPR029071", "properties": [{"key": "EntryName", "value": "Ubiquitin-like_domsf"}]}, {"database": "Pfam", "id": "PF00240", "properties": [{"key": "EntryName", "value": "ubiquitin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00213", "properties": [{"key": "EntryName", "value": "UBQ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54236", "properties": [{"key": "EntryName", "value": "Ubiquitin-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50053", "properties": [{"key": "EntryName", "value": "UBIQUITIN_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MILKVRGPGKRIEDVTINLLMQVKELKEKIGNIFQVEPENQRLILRGKQLKDEHKLWDYGVQIYDTVLLTVTQKVIQKEVVTANQEPFSLIKHLKTLRQISQSKYFKVGEYVDFLDTHFGAWFQGKIKIIYVEDQARLDAISEEVDLPSQRNGDSKEDGDITVVDDNTEDTPAANTLHRDSPVVISDDESIDVVTVRSSSPDSVIYIPQDNEPVIYIPPDEELGVCVPPPVYVEPYSISVRTVETINNSPELRVQEETTCLQSSQKTCAVSDTNGVNTVNTAGSARNSNGSDQGVQQETTYDRSSDDVNAASETRGRKTVGSTGRKTGGTRGGKTVGAPGRKTVGAPCKQTDDTTEFTPRPNETKQEALQRALQEALQAMSWGEFSDKTNAVSDTDHSESGDSGHSSHMSSKNIPQSKEWPGSEEAANQ", "length": 429, "molWeight": 47329, "crc64": "F60B770A3F3E7922", "md5": "48BDC06AAC7DB83FF5E0EE2EB16E1C16"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 3, "Compositional bias": 2, "Non-terminal residue": 1}, "uniParcId": "UPI0035D2D9B3"}, "cluster_size": 1, "family": "Acrididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB13A910", "uniProtkbId": "A0AB13A910_DANRE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Danio rerio", "commonName": "Zebrafish", "synonyms": ["Brachydanio rerio"], "taxonId": 7955, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}, {"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "NP_001373651.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Cypriniformes", "Danionidae", "Danioninae", "Danio"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "NP_001373651.1"}], "value": "Uncharacterized protein LOC558782"}}]}, "genes": [{"orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "NP_001373651.1"}, {"evidenceCode": "ECO:0000313", "source": "ZFIN", "id": "ZDB-GENE-081022-37"}], "value": "zgc:193742"}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 49, "modifier": "EXACT"}, "end": {"value": 71, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "Distal membrane-arm assembly complex protein 1-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF15055"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AB13A910"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "12477932", "citationType": "journal article", "authoringGroup": ["Mammalian Gene Collection Program Team"], "authors": ["Strausberg R.L.", "Feingold E.A.", "Grouse L.H.", "Derge J.G.", "Klausner R.D.", "Collins F.S.", "Wagner L.", "Shenmen C.M.", "Schuler G.D.", "Altschul S.F.", "Zeeberg B.", "Buetow K.H.", "Schaefer C.F.", "Bhat N.K.", "Hopkins R.F.", "Jordan H.", "Moore T.", "Max S.I.", "Wang J.", "Hsieh F.", "Diatchenko L.", "Marusina K.", "Farmer A.A.", "Rubin G.M.", "Hong L.", "Stapleton M.", "Soares M.B.", "Bonaldo M.F.", "Casavant T.L.", "Scheetz T.E.", "Brownstein M.J.", "Usdin T.B.", "Toshiyuki S.", "Carninci P.", "Prange C.", "Raha S.S.", "Loquellano N.A.", "Peters G.J.", "Abramson R.D.", "Mullahy S.J.", "Bosak S.A.", "McEwan P.J.", "McKernan K.J.", "Malek J.A.", "Gunaratne P.H.", "Richards S.", "Worley K.C.", "Hale S.", "Garcia A.M.", "Gay L.J.", "Hulyk S.W.", "Villalon D.K.", "Muzny D.M.", "Sodergren E.J.", "Lu X.", "Gibbs R.A.", "Fahey J.", "Helton E.", "Ketteman M.", "Madan A.", "Rodrigues S.", "Sanchez A.", "Whiting M.", "Madan A.", "Young A.C.", "Shevchenko Y.", "Bouffard G.G.", "Blakesley R.W.", "Touchman J.W.", "Green E.D.", "Dickson M.C.", "Rodriguez A.C.", "Grimwood J.", "Schmutz J.", "Myers R.M.", "Butterfield Y.S.", "Krzywinski M.I.", "Skalska U.", "Smailus D.E.", "Schnerch A.", "Schein J.E.", "Jones S.J.", "Marra M.A."], "citationCrossReferences": [{"database": "PubMed", "id": "12477932"}, {"database": "DOI", "id": "10.1073/pnas.242603899"}], "title": "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.", "publicationDate": "2002", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "16899", "lastPage": "16903", "volume": "99"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "NP_001373651.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "NP_001373651.1"}]}, {"referenceNumber": 2, "citation": {"id": "21873635", "citationType": "journal article", "authors": ["Gaudet P.", "Livstone M.S.", "Lewis S.E.", "Thomas P.D."], "citationCrossReferences": [{"database": "PubMed", "id": "21873635"}, {"database": "DOI", "id": "10.1093/bib/bbr042"}], "title": "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.", "publicationDate": "2011", "journal": "Brief. Bioinform.", "firstPage": "449", "lastPage": "462", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "NP_001373651.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "NP_001373651.1"}]}, {"referenceNumber": 3, "citation": {"id": "CI-FT6AD0HQEQTFJ", "citationType": "submission", "authoringGroup": ["RefSeq"], "publicationDate": "APR-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "NP_001373651.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "NP_001373651.1"}]}], "uniProtKBCrossReferences": [{"database": "RefSeq", "id": "NP_001373651.1", "properties": [{"key": "NucleotideSequenceId", "value": "NM_001386722.1"}]}, {"database": "GeneID", "id": "558782", "properties": [{"key": "Description", "value": "-"}]}, {"database": "KEGG", "id": "dre:558782", "properties": [{"key": "Description", "value": "-"}]}, {"database": "ZFIN", "id": "ZDB-GENE-081022-37", "properties": [{"key": "GeneName", "value": "zgc:193742"}]}, {"database": "Proteomes", "id": "UP000000437", "properties": [{"key": "Component", "value": "Alternate scaffold 10"}]}, {"database": "Proteomes", "id": "UP000000437", "properties": [{"key": "Component", "value": "Chromosome 10"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR028036", "properties": [{"key": "EntryName", "value": "DMAC1-like_dom"}]}, {"database": "Pfam", "id": "PF15055", "properties": [{"key": "EntryName", "value": "DMAC1_Dmo2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSNPPPLLEHTLEAFFNCWRCRVVACGGLIASGLFVFGAARRRNLGRPFNLFTAVQMASATGLITSGLLVIDERVGMKDTGK", "length": 82, "molWeight": 8869, "crc64": "85A325BB7F4BDA47", "md5": "FAA0A454D6E5B7FDCFC0CD9646E31AC9"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2, "Domain": 1}, "uniParcId": "UPI00005469C9"}, "cluster_size": 2, "family": "Danionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6R3S2", "uniProtkbId": "A0AAU6R3S2_9METZ", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucetta chagosensis", "taxonId": 185688, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC81643.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Calcarea", "Calcinea", "Clathrinida", "Leucettidae", "Leucetta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00040165"}], "value": "X-box-binding protein 1"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC81643.1"}], "value": "XBP1_2"}}], "features": [{"type": "Domain", "location": {"start": {"value": 27, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "BZIP", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50217"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38952658", "citationType": "journal article", "authors": ["Posadas N.", "Conaco C."], "citationCrossReferences": [{"database": "PubMed", "id": "38952658"}], "title": "Gene networks governing the response of a calcareous sponge to future ocean conditions reveal lineage-specific XBP1 regulation of the unfolded protein response.", "publicationDate": "2024", "journal": "Ecol. Evol.", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC81643.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-B6JVVS90CVM02", "citationType": "submission", "authors": ["Posadas N.", "Conaco C."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC81643.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP627506", "properties": [{"key": "ProteinId", "value": "WZC81643.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.20.5.170", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR004827", "properties": [{"key": "EntryName", "value": "bZIP"}]}, {"database": "InterPro", "id": "IPR046347", "properties": [{"key": "EntryName", "value": "bZIP_sf"}]}, {"database": "InterPro", "id": "IPR052470", "properties": [{"key": "EntryName", "value": "ER_Stress-Reg_TF"}]}, {"database": "PANTHER", "id": "PTHR46542", "properties": [{"key": "EntryName", "value": "X-BOX BINDING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46542:SF1", "properties": [{"key": "EntryName", "value": "X-BOX BINDING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00170", "properties": [{"key": "EntryName", "value": "bZIP_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00338", "properties": [{"key": "EntryName", "value": "BRLZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57959", "properties": [{"key": "EntryName", "value": "Leucine zipper domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50217", "properties": [{"key": "EntryName", "value": "BZIP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDCTAISLDPEKYRPRKREKLDHLSPEEKLKRRKVFNRVSAQIARDRRKNYLDRLERLVATLRAENEALVVDNRSLNLSLTNLREEHIRLRSKFATSTLPASPNTFESRSVDLQPGSESAELIVSRQQKHQAVSLPITLLVAAMLSMSSVNLDSYSNLDSILAMDSLVHLKASAHLPVRPTSVFSPSLRQIAQLPLHQSPLFLPATSLRSTQKCSTLTCSAWIRMIRPKPRLAVKTSQ", "length": 238, "molWeight": 26886, "crc64": "C2F656601EC042F6", "md5": "CBEF4052B6C11200744718C313EB5DCD"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D39B56"}, "cluster_size": 2, "family": "Leucettidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LPN2", "uniProtkbId": "A0AAN0LPN2_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34101.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34101.1"}], "value": "Tachykinin-like peptide receptor 99D"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 70, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 82, "modifier": "EXACT"}, "end": {"value": 107, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 119, "modifier": "EXACT"}, "end": {"value": 138, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 159, "modifier": "EXACT"}, "end": {"value": 180, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 213, "modifier": "EXACT"}, "end": {"value": 236, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 268, "modifier": "EXACT"}, "end": {"value": 289, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 309, "modifier": "EXACT"}, "end": {"value": 327, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 61, "modifier": "EXACT"}, "end": {"value": 324, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}, {"type": "Region", "location": {"start": {"value": 399, "modifier": "EXACT"}, "end": {"value": 429, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34101.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155027", "properties": [{"key": "ProteinId", "value": "WRW34101.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004995", "properties": [{"key": "GoTerm", "value": "F:tachykinin receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd15390", "properties": [{"key": "EntryName", "value": "7tmA_TACR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR001681", "properties": [{"key": "EntryName", "value": "Neurokn_rcpt"}]}, {"database": "PANTHER", "id": "PTHR46925", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46925:SF2", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "PRINTS", "id": "PR00244", "properties": [{"key": "EntryName", "value": "NEUROKININR"}]}, {"database": "SMART", "id": "SM01381", "properties": [{"key": "EntryName", "value": "7TM_GPCR_Srsx"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLALLNDSIMSNSTILSLKNLEENLDNKIQVNLQDSYSRELWQVIFWSFIFGFMVIIATTGNLIVIMIVLLNKQMRTITNLFIVNLSIADIMVSTMNVIFNFVYMLNGYWWFGSTYCKVSNFIAIMSVAASVFTLMAISIDRYIAIVYPLKPRMSLMTTLNIAIGIWCASSLLSAPNFIFSITQQETLPNGEIKIICLIKWPDGVAPGSKFDYFYNLAVLILTYFIPITLMALTYFRVGTVLWGSQTIGEYTAKQVQSIQSKRKIVKMLILVLCIFAVCWLPYHIYFIIQHHLPEITNFKYAQQIYLVLYWLAMSNSMYNPFIYCWMNNRFRRGFRNILFCKYCFKTNPSNNKKFRIRILKENDQIYLNEFQNSEQQPSNEQRNSTWYESFNKKQTNKLTNTSQNSNFFSGQKNDLKSSSNASTSKDISPNISDKMMMYIDNKSNIKICMASDVKNDNVNTLKNKLSVQKKEYTDSSIENSILKVKQPNKIEMNEVDLVKTIYKKENIIIKKHVIKKNLDDENANQNGEENCTKN", "length": 535, "molWeight": 62062, "crc64": "DF5904512C9C6807", "md5": "E518695DB6E3FD4088C9FE897DC96D7F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1, "Region": 1}, "uniParcId": "UPI0032481737"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LW06", "uniProtkbId": "A0AAN0LW06_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34093.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34093.1"}], "value": "Epithelial sodium channel/degenerin-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007193"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "value": "Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 221, "modifier": "EXACT"}, "end": {"value": 242, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 817, "modifier": "EXACT"}, "end": {"value": 837, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 340, "modifier": "EXACT"}, "end": {"value": 422, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 341, "modifier": "EXACT"}, "end": {"value": 353, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 354, "modifier": "EXACT"}, "end": {"value": 364, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 380, "modifier": "EXACT"}, "end": {"value": 389, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 390, "modifier": "EXACT"}, "end": {"value": 422, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023053"}], "id": "KW-0915", "category": "Ligand", "name": "Sodium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022461"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0894", "category": "Molecular function", "name": "Sodium channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023201"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0739", "category": "Biological process", "name": "Sodium transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34093.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155019", "properties": [{"key": "ProteinId", "value": "WRW34093.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0015280", "properties": [{"key": "GoTerm", "value": "F:ligand-gated sodium channel activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.60.470.10", "properties": [{"key": "EntryName", "value": "Acid-sensing ion channels like domains"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.770", "properties": [{"key": "EntryName", "value": "YojJ-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001873", "properties": [{"key": "EntryName", "value": "ENaC"}]}, {"database": "PANTHER", "id": "PTHR11690", "properties": [{"key": "EntryName", "value": "AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11690:SF248", "properties": [{"key": "EntryName", "value": "PICKPOCKET 17, ISOFORM A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00858", "properties": [{"key": "EntryName", "value": "ASC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01078", "properties": [{"key": "EntryName", "value": "AMINACHANNEL"}]}], "sequence": {"value": "MNFKNKVLNDKIESTQQYLNKRLPWYCETTSPVQWFKQFSNDQFPKVKYKINQNFNKTDSSIEIEKNDNKNDTESNSSITYVKKSNQDLDTIENLKNSNNLSIIIENQLNRFSKNQIDKNEFDKKEIEKNENLRKFSNSSYNQEPWRKFNYPGFRNINFKGSSLSSFKKSSIKKNFFKLKPFVTNFRQRSSSFINLKDMFADSSVPGVREICNSNNNFRKIIWLITFVLFSFLALNAIQQLLSDFYSYPITVDMRMRESRKLAFPAVTICNLNIVRYSALCNSTLNVSMPIELQEKLCGISLSTSKNTSIEDINDILPDSDQGIKTTTLDDYFNYEDEVGNDSTTAKQDSSTHVNRKHKQKFSSKKTNFTDESTTTYKPKITKKTRFKRSPTSNTNTKSHGATGTVSNPNSNINKVTSFPSDTSTEVEMIELTEREEKELQENLTTWLAVMANKNKNLTFFLGHQFDDMILRCTIKSTNCTHPNSFVSSFTPTEGNCYTFIAKTNTNPSPSHTTFKPTTPMSTVTQSTFETSDSFTGTSESPKINPPLQVELFSTTEPPDLSTKTERTTEKKIITTYNEPEHNQVETILAGADHGLELVINLEKNEYLPGTAQIGALVMVHSPDDFGISASEAIMVSPGCATYIGLKMVKISRLPAPYPEQCVDIWPKGLQRKSMLNASYSQQACIKICLQKTIFKRCKCQSAFLEQFEFNGTELRICDTRKRNTRRCVEEVMLRPENKLEDCKCPPRCQVIQYEKTVSLARWPTREDRVSFDRGTKDISISNVAKVVVYYQTMTLQEVTQQAAWTSAKLLSSIGGFMGMYVGFSFLSLFELFEIFFRRIWFLMSRKRPSFKIIAKIIQALIRTRNAAKKNHQNVA", "length": 876, "molWeight": 100382, "crc64": "65708FE0EC1E505B", "md5": "CAB2270BC7FE6D2AED9B42657CCCB88C"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 2, "Region": 1, "Compositional bias": 4}, "uniParcId": "UPI00324F7148"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7B995", "uniProtkbId": "A0AAU7B995_PYRAP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Pyrrhocoris apterus", "commonName": "Sap sucking bug", "synonyms": ["Cimex apterus"], "taxonId": 37000, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28253.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Pentatomomorpha", "Pyrrhocoroidea", "Pyrrhocoridae", "Pyrrhocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011902"}], "value": "receptor protein-tyrosine kinase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011902"}], "value": "2.7.10.1"}]}}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:10596"}, {"database": "Rhea", "id": "RHEA-COMP:10136"}, {"database": "Rhea", "id": "RHEA-COMP:20101"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:46858"}, {"database": "ChEBI", "id": "CHEBI:61978"}, {"database": "ChEBI", "id": "CHEBI:456216"}], "ecNumber": "2.7.10.1", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00051243"}]}}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Single-pass type I membrane protein", "id": "SL-9905"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 770, "modifier": "EXACT"}}, "description": "receptor protein-tyrosine kinase", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043515173"}, {"type": "Transmembrane", "location": {"start": {"value": 380, "modifier": "EXACT"}, "end": {"value": 400, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 448, "modifier": "EXACT"}, "end": {"value": 753, "modifier": "EXACT"}}, "description": "Protein kinase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50011"}]}, {"type": "Region", "location": {"start": {"value": 409, "modifier": "EXACT"}, "end": {"value": 429, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 419, "modifier": "EXACT"}, "end": {"value": 429, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 479, "modifier": "EXACT"}, "end": {"value": 479, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022777"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28253.1"}], "id": "KW-0418", "category": "Molecular function", "name": "Kinase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28253.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023137"}], "id": "KW-0829", "category": "Molecular function", "name": "Tyrosine-protein kinase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-6ACPSJKDM67VK", "citationType": "submission", "authors": ["Zhang J.-L.", "Xu H.-J."], "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28253.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP813840", "properties": [{"key": "ProteinId", "value": "XBC28253.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043235", "properties": [{"key": "GoTerm", "value": "C:receptor complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0004714", "properties": [{"key": "GoTerm", "value": "F:transmembrane receptor protein tyrosine kinase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007169", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor protein tyrosine kinase signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:1902533", "properties": [{"key": "GoTerm", "value": "P:positive regulation of intracellular signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "CDD", "id": "cd00063", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00192", "properties": [{"key": "EntryName", "value": "PTKc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.510.10:FF:000190", "properties": [{"key": "EntryName", "value": "Proto-oncogene tyrosine-protein kinase receptor Ret"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.200.20", "properties": [{"key": "EntryName", "value": "Phosphorylase Kinase, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.510.10", "properties": [{"key": "EntryName", "value": "Transferase(Phosphotransferase) domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR003961", "properties": [{"key": "EntryName", "value": "FN3_dom"}]}, {"database": "InterPro", "id": "IPR036116", "properties": [{"key": "EntryName", "value": "FN3_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR011009", "properties": [{"key": "EntryName", "value": "Kinase-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR000719", "properties": [{"key": "EntryName", "value": "Prot_kinase_dom"}]}, {"database": "InterPro", "id": "IPR017441", "properties": [{"key": "EntryName", "value": "Protein_kinase_ATP_BS"}]}, {"database": "InterPro", "id": "IPR050122", "properties": [{"key": "EntryName", "value": "RTK"}]}, {"database": "InterPro", "id": "IPR001245", "properties": [{"key": "EntryName", "value": "Ser-Thr/Tyr_kinase_cat_dom"}]}, {"database": "InterPro", "id": "IPR008266", "properties": [{"key": "EntryName", "value": "Tyr_kinase_AS"}]}, {"database": "InterPro", "id": "IPR020635", "properties": [{"key": "EntryName", "value": "Tyr_kinase_cat_dom"}]}, {"database": "PANTHER", "id": "PTHR24416", "properties": [{"key": "EntryName", "value": "TYROSINE-PROTEIN KINASE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24416:SF620", "properties": [{"key": "EntryName", "value": "TYROSINE-PROTEIN KINASE RECEPTOR TORSO"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07714", "properties": [{"key": "EntryName", "value": "PK_Tyr_Ser-Thr"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00109", "properties": [{"key": "EntryName", "value": "TYRKINASE"}]}, {"database": "SMART", "id": "SM00060", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00219", "properties": [{"key": "EntryName", "value": "TyrKc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49265", "properties": [{"key": "EntryName", "value": "Fibronectin type III"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56112", "properties": [{"key": "EntryName", "value": "Protein kinase-like (PK-like)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00107", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_ATP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50011", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00109", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_TYR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSTITSCLITLFQLHLLIVRCKPNDNYNGNSLEPHTQFREESCNGTCTNSTTSEVPDSGTDLTIGKIKLYCRDEKKLAVVWSCSERDTDFLVDYQSEYNGQWINEIIVHKPIAVINNVSGGYVFRITPQKRFNKHKGKPRNSATFYTLSRNLPLSRISSANVSLHASFESYMNAVLRWQPIKEKVCGYGIIIWKVGVESFELEPSVEDLYEVLLEDLQYSTEYRIGIYAFTKKNEGPKYWIQYYTPSCAKINDYDYNFCIPEKPENFSVVEDDCVLRMSWTRPPKSPDGYFLRIHDLLNRSVTDKEISKEQTNLNVKISGLGEYLQIQFYAVANSKKGEEIVKRIKTQCPFKEEEKLQKIAKHIGNMYKFVDGFVRSPELSFALISIVIVITFVVIFVLLRHRRTRPRASEETQTSIKADIREDTKSTHEEPVKPLINNEYEIQANMLVMLETVGKGEFGIVSKAILKSLDKELEVAVKSLRKNATKEDEECFQTELEVMKIVGKHKNLVSLIGYCSSDNLLIVEFCAFGDLQRFLREARKTKILLQKMVSMAPEDEEMWRNAVSNIIYDRTDLEKKHMELNSMDLLSFARQVAIGMEYLSTNKIIHRDLAARNILLTSNLTAKISDFGLSRDIYLESVYRRKNNSKLPIKWMAPESLSHQLFTTHSDVWSFGVLLWEIMTLGGSPYPSMPSAMIYKLLRNGYRMEKPPSCKEEVYDIMKCCWKDTPFKRPSFTNISNALDKLIGEESAHEYLELNTDSIDYAHTNEIDD", "length": 770, "molWeight": 88709, "crc64": "3855A8138B93B2F4", "md5": "6E3744E3B1B4C50CA7BDDDD28545660E"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 1, "Region": 1, "Compositional bias": 1, "Binding site": 1}, "uniParcId": "UPI0035D2CDFC"}, "cluster_size": 1, "family": "Pyrrhocoridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N6B1", "uniProtkbId": "A0AAJ6N6B1_9GAMM", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hahella ganghwensis", "taxonId": 286420, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8H0L"}], "lineage": ["Bacteria", "Pseudomonadati", "Pseudomonadota", "Gammaproteobacteria", "Oceanospirillales", "Hahellaceae", "Hahella"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8H0L"}], "value": "SBDHga1"}}]}, "features": [{"type": "Binding site", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8H0L"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8H0L"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8H0L"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "37702119", "citationType": "journal article", "authors": ["Hu W.", "Yang B.", "Xiao Q.", "Wang Y.", "Shuai Y.", "Zhao G.", "Zhang L.", "Deng Z.", "He X.", "Liu G."], "citationCrossReferences": [{"database": "PubMed", "id": "37702119"}, {"database": "DOI", "id": "10.1093/nar/gkad743"}], "title": "Characterization of a promiscuous DNA sulfur binding domain and application in site-directed RNA base editing.", "publicationDate": "2023", "journal": "Nucleic Acids Res.", "firstPage": "10782", "lastPage": "10794", "volume": "51"}, "referencePositions": ["X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH MG(2+)"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8H0L"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8H0L", "properties": [{"key": "Method", "value": "X-ray"}, {"key": "Resolution", "value": "1.80 A"}, {"key": "Chains", "value": "A/B=1-163"}]}, {"database": "SMR", "id": "A0AAJ6N6B1", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "GSHMSLLEYEAKFSELNPNRRHGNTSPHKIAMLLAVMDLIESGSLQENRIYFDRQLKDAFTKRFNELKSEADRDNPHLPYYHLHTSGFWHHQVNPGQRESYKTMSASGASAIDQHIAYAYLDEELFELLQNFTVRKLLTSALDRNFAITETSRKSILGSNNHW", "length": 163, "molWeight": 18867, "crc64": "1A0CB81B5199C082", "md5": "EAAAF8465C2A57B6D68A34DA08215276"}, "extraAttributes": {"countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI002888F8FE"}, "cluster_size": 1, "family": "Hahellaceae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXW4", "uniProtkbId": "TXU22_MEGOP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Megalopyge opercularis", "commonName": "Southern flannel moth", "synonyms": ["Phalaena opercularis"], "taxonId": 1113279, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Megalopygidae", "Megalopyge"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-megalopygitoxin(2)-Mo2"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-MPTX(2)-Mo2"}, {"evidences": [{"evidenceCode": "ECO:0000312", "source": "EMBL", "id": "WJJ70364.1"}], "value": "U-MPTX.2-2"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Probable toxin"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Expressed by the venom apparatus"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Larvae"}], "commentType": "DEVELOPMENTAL STAGE"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "value": "Contains 2 disulfide bonds"}], "commentType": "PTM"}, {"commentType": "MASS SPECTROMETRY", "method": "MALDI", "molWeight": 2717.26, "molWeightError": 0.0, "note": "Monoisotopic mass.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the caterpillar 2 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Peptide", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "U-megalopygitoxin(2)-Mo2", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "featureId": "PRO_0000461522"}], "keywords": [{"id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "37428925", "citationType": "journal article", "authors": ["Walker A.A.", "Robinson S.D.", "Merritt D.J.", "Cardoso F.C.", "Goudarzi M.H.", "Mercedes R.S.", "Eagles D.A.", "Cooper P.", "Zdenek C.N.", "Fry B.G.", "Hall D.W.", "Vetter I.", "King G.F."], "citationCrossReferences": [{"database": "PubMed", "id": "37428925"}, {"database": "DOI", "id": "10.1073/pnas.2305871120"}], "title": "Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).", "publicationDate": "2023", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "e2305871120", "lastPage": "e2305871120", "volume": "120"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "MASS SPECTROMETRY", "SYNTHESIS OF 30-55", "SUBCELLULAR LOCATION", "TISSUE SPECIFICITY", "DEVELOPMENTAL STAGE"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP514846", "properties": [{"key": "ProteinId", "value": "WJJ70364.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MKFVVLLMIVAAAVAMFAAGTEAFPEPIPASNNFLRKRCAGQGKCIGNGECVPCP", "length": 55, "molWeight": 5741, "crc64": "1C0FB2BAC7245C5D", "md5": "5EAA686B2303F25E241B61206CE600D0"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "DEVELOPMENTAL STAGE": 1, "PTM": 1, "MASS SPECTROMETRY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Peptide": 1}, "uniParcId": "UPI00388C339E"}, "cluster_size": 1, "family": "Megalopygidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAV2KUV4", "uniProtkbId": "A0AAV2KUV4_KNICA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Knipowitschia caucasica", "commonName": "Caucasian dwarf goby", "synonyms": ["Pomatoschistus caucasicus"], "taxonId": 637954, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "CAL1592806.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001497482"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Neoteleostei", "Acanthomorphata", "Gobiaria", "Gobiiformes", "Gobioidei", "Gobiidae", "Gobiinae", "Knipowitschia"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}], "value": "Ig-like domain-containing protein"}}}, "genes": [{"orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "CAL1592806.1"}], "value": "KC01_LOCUS22011"}]}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004498"}], "value": "Secreted, extracellular space, extracellular matrix", "id": "SL-0111"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 349, "modifier": "EXACT"}, "end": {"value": 433, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022685"}], "id": "KW-0165", "category": "PTM", "name": "Cleavage on pair of basic residues"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022530"}], "id": "KW-0272", "category": "Cellular component", "name": "Extracellular matrix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023319"}], "id": "KW-0393", "category": "Domain", "name": "Immunoglobulin domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047216"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001497482"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5V4QA5VRBKBFU", "citationType": "submission", "authors": ["Waldvogel A.-M.", "Schoenle A."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "CAL1592806.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001497482"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OZ035824", "properties": [{"key": "ProteinId", "value": "CAL1592806.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP001497482", "properties": [{"key": "Component", "value": "Chromosome 2"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "2.60.40.10:FF:001254", "properties": [{"key": "EntryName", "value": "Cartilage intermediate layer protein 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.20.100.10", "properties": [{"key": "EntryName", "value": "Thrombospondin type-1 (TSP1) repeat"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR008969", "properties": [{"key": "EntryName", "value": "CarboxyPept-like_regulatory"}]}, {"database": "InterPro", "id": "IPR056258", "properties": [{"key": "EntryName", "value": "CILP-1/2_C"}]}, {"database": "InterPro", "id": "IPR056255", "properties": [{"key": "EntryName", "value": "CILP-1/2_dom"}]}, {"database": "InterPro", "id": "IPR039675", "properties": [{"key": "EntryName", "value": "CILP1/CILP2"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR003598", "properties": [{"key": "EntryName", "value": "Ig_sub2"}]}, {"database": "InterPro", "id": "IPR000884", "properties": [{"key": "EntryName", "value": "TSP1_rpt"}]}, {"database": "InterPro", "id": "IPR036383", "properties": [{"key": "EntryName", "value": "TSP1_rpt_sf"}]}, {"database": "InterPro", "id": "IPR025155", "properties": [{"key": "EntryName", "value": "WxxW_domain"}]}, {"database": "PANTHER", "id": "PTHR15031:SF0", "properties": [{"key": "EntryName", "value": "CARTILAGE INTERMEDIATE LAYER PROTEIN 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR15031", "properties": [{"key": "EntryName", "value": "CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23708", "properties": [{"key": "EntryName", "value": "CILP_5th"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23599", "properties": [{"key": "EntryName", "value": "CILP_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13927", "properties": [{"key": "EntryName", "value": "Ig_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13330", "properties": [{"key": "EntryName", "value": "Mucin2_WxxW"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00090", "properties": [{"key": "EntryName", "value": "TSP_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00408", "properties": [{"key": "EntryName", "value": "IGc2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00209", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF49464", "properties": [{"key": "EntryName", "value": "Carboxypeptidase regulatory domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF82895", "properties": [{"key": "EntryName", "value": "TSP-1 type 1 repeat"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50092", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MSALLSVGFGQGSLRPRHPSVDSGHEAYNSYSYSQSTAVTEWTSWFNIDHPGGNGDYERLEAIRFYYRERVCVRPTAMEVRTTDWVSAADTGEVVHSSLDKGFWCVNKEQPHGRICSNYHVRFQCPPVQSYWSDWSEWGPCSTSVCNDAGIQTRHRKCLSSQPMPLLLVPACQGHHTDRRECSTPPCTAKWSPWGQWGDCSVSCGGGRRVRRRTCIKNSPTVQCTGRPAEMQKCGKSPCPVRCQMSCSEGRPIEDCSRCVCDGHVLLGEVHSMTGVPVSGASVSLPSQPKVILARTDNKGQFKLPGVCSSSSALVSIRKDKFAPVTVAATSNTTGRSWIKTVLKTAEKPYIVKHPEDKVRYEGGRVLLCCKATGSPLPDKYYWYHNGTLLDRKVNKYEEDLVLRDLRPEQSGHYYCKTSSSAGSIKSAPALLTVIAKGAAACNSSPEPHLVRMPVDCVQPGTDSAFYNAGRCPHNKCPGPLDYDLRCRDGAGFCCAVKTMEARTINCGSYNQNPRVAKEIAIGRCFDGTSDGFSREMKADAGIALTFHCPERKINREGLFQRLQTNPGQTLAQMARDMRELEGVQVQRSRVVAYPGSKYYFIDLESRVIVDNLMLLSMNHF", "length": 621, "molWeight": 68794, "crc64": "DF2A063431492BB6", "md5": "35B38B76C792FCA8B71239DFCEDF9BB1"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI003366F913"}, "cluster_size": 1, "family": "Gobiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UVB2", "uniProtkbId": "A0AAT9UVB2_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41619.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41619.1"}], "value": "Cytochrome P450 6PZ14"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003690"}], "value": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides"}], "commentType": "FUNCTION"}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 5, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 469, "modifier": "EXACT"}, "end": {"value": 469, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41619.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117179", "properties": [{"key": "ProteinId", "value": "WIM41619.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000042", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002403", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-IV"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00465", "properties": [{"key": "EntryName", "value": "EP450IV"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MHTVAFDCTALMIISFVLYMYWSLKQIYLFFEKLDIPFITPNLLLGNMTDVVLLRKSLAEVYVDLYRQLEPHKFGGVFTPMKPVVIIRDPELLKDVLIKNFALTNDRGFHIDSQVEPLSHNLFTMKGEEWKNLRIKLTGTFSSLKMKMMFPLVKSCGEKLDKVLAQIPPNKAFDIKEISARYTTDVIGTCAFGLEINSLENPNSEFRLIGKKAFQFRFKALIRTLWMTMPTQLIQLFDLTFFDSKVQNFFSSLVYKTIQHREENNVTRDDFLDLLIALKTNTASQLLHDTKDGEDLKTFLDQVGDKGVKKDIKMTDELIAAQAFLFFAAGFETSSTTLSYALLELALNQTIQHEVRQEIHRVFSTTDEHLSYEMLAQMPYTDMVISETLRKYPPSSLLFRKTCRNYKIPNTRITLPEDTSVIIPVYGLHLDEKYYPNPQEFRPERFTEEEKNKRPNYTYLPFGEGPRTCIARRFAKMSIKIGLIYALKNASYTVSPKMKFPVQFQINFGLLTARNKIWLQRQPI", "length": 524, "molWeight": 60817, "crc64": "11958ACB86FDE914", "md5": "74A5E8F5B8B8BB928B2E6A1B98EE2A57"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D37B69"}, "cluster_size": 24, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEX0", "uniProtkbId": "A0AB38ZEX0_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02790.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02790.1"}], "value": "Venom S1 protease 43"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 432, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044256843"}, {"type": "Domain", "location": {"start": {"value": 183, "modifier": "EXACT"}, "end": {"value": 415, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02790.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02790.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517540", "properties": [{"key": "ProteinId", "value": "WXI02790.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00190", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.40.10.10:FF:000068", "properties": [{"key": "EntryName", "value": "transmembrane protease serine 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001314", "properties": [{"key": "EntryName", "value": "Peptidase_S1A"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR018114", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24252", "properties": [{"key": "EntryName", "value": "ACROSIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24252:SF7", "properties": [{"key": "EntryName", "value": "HYALIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00722", "properties": [{"key": "EntryName", "value": "CHYMOTRYPSIN"}]}, {"database": "SMART", "id": "SM00020", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00134", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLRAETFWAILAMIGFAHYANCAVLQPIKNDIIIKGNVINRDISGNFTPHTHLKYRFRCDKGKSMYVRCQMNVQFTQDPKGSCAPFQLKVYSGTRLRWQCMTEKFFPFISENDLMDLTIDTGDGIKGGNVSCEVKAVHKVVHSLYKNVASEEVDSSEFGQKNVNGPKKTTCDCGWSNKDPKRILFGKEAGKHEYPWSVSLQMKEGKFHFCGGSIITPYHVITAAHCTLNRAASKIIVVMGTNNRSDNTISSDVKKIYDHNYHRKMFINDISIIEVVDKITFNQFIGPVCLPTRDPGLVRKYVTAMGWGRMHDSEYKTRDVTMMKKTNMRVVDIDSCSLDWVYIWEVDDPKVICTWSNHTDICLGDSGGPVVFYDTEIKRYTLVGLPALSDTCKLVRPAAHTAVHYFHKWILNTIANSIQPEARTAQVCTKID", "length": 432, "molWeight": 48979, "crc64": "D2A8DC6050D3A7E0", "md5": "E38D87FA3A4EEC7C9BA66967858C7771"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388BDB04"}, "cluster_size": 2, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96SGH8", "uniProtkbId": "A0AA96SGH8_PAELC", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia lactiflora", "commonName": "Chinese peony", "synonyms": ["Paeonia albiflora"], "taxonId": 35924, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94115.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0008006", "source": "Google", "id": "ProtNLM"}], "value": "Transposase Tnp1/En/Spm-like domain-containing protein"}}}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 514, "modifier": "EXACT"}, "end": {"value": 538, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 481, "modifier": "EXACT"}, "end": {"value": 508, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 11, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 59, "modifier": "EXACT"}, "end": {"value": 75, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 99, "modifier": "EXACT"}, "end": {"value": 122, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 135, "modifier": "EXACT"}, "end": {"value": 144, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-816JBB05UD0I7", "citationType": "submission", "authors": ["Shi Y.J."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94115.1"}], "value": "S-CPA C", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94115.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR552628", "properties": [{"key": "ProteinId", "value": "WNT94115.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR004252", "properties": [{"key": "EntryName", "value": "Probable_transposase_24"}]}, {"database": "PANTHER", "id": "PTHR33018:SF34", "properties": [{"key": "EntryName", "value": "OS02G0472350 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR33018", "properties": [{"key": "EntryName", "value": "OS10G0338966 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03004", "properties": [{"key": "EntryName", "value": "Transposase_24"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAITRSSKRRPVTVSAPQTRNGDFGQPIDSLVIQAMPNSSSGNDRLQKKVTRDQTSMDVIRKGKSTDVISKERVSCTEVEANGPGQPDTLAASEHERDEESYEVDDEDDAHETSDSDDDAQETSDSSFGDDQQPKKRKRGRPRKVVIGNGQALPTDVEHNPVIQPLVIAASQSESHDDTLVSDETSYSPSISLAAQRMTISYNRNSQGRKKWRRDRDKIYVIANRKRSLTKVEFNELGQPVGDNAASFVSFLGCLVREKIPITSLERWKGLSIQCKDDLWSSVQQNYRINDCYRKDILKRMGMSWRNYKGKITKEIYKISQSDDASHQLALLKPDNIKSSEEWEAFVKQRTSAEFKVMSEKYRRLRANQPLLHTLGRRGYACLLHEMKKKSPTPSKITRVDVWTRAHLRKDGKPINEAAAESIRKLEEYSKSPEAQTGISPREDALAKLFGPERRDQVRGLGFGATASKVDVEIRGSGSKVHRLEYEVKDLRQQVVDLKAMLLQETRQKFLQGQNVSDEDTMHSSKDIPQGCNVRDEETMHSSGAISQDWNARGEEMMHPSGDTQDNLRDEGMMHSSGAAATQGQNVRDEGMVHSSRAIPLGQNASEEEMVCSYKATRQGPSRDEQMVYSRRATPQISVGLFSCLGRNVRDEKMMWHFSSTTTKGQNVRDEGMMHSSEAISLDQNVRDEGMVYSSRATTQGQNVRDGEMMMHSSRVITQGEEREIMHKSGATTQAQPGSDNLVPANCKLIHWMGTEVVANAELVSKDPRKLVHLVKLGPDCWEVRVNQVTVDDVPLYRPTIKMFCLEDAVGSMVAWPSKYITME", "length": 824, "molWeight": 92694, "crc64": "E4CE953E41D7A222", "md5": "D85CBC3BB9CD507BCD22EE82246385FC"}, "extraAttributes": {"countByFeatureType": {"Region": 2, "Coiled coil": 1, "Compositional bias": 4}, "uniParcId": "UPI002B3213F3"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB32TZ50", "uniProtkbId": "A0AB32TZ50_DANRE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Danio rerio", "commonName": "Zebrafish", "synonyms": ["Brachydanio rerio"], "taxonId": 7955, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}, {"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080317.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Cypriniformes", "Danionidae", "Danioninae", "Danio"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080317.1"}], "value": "Uncharacterized protein isoform X2"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080317.1"}, {"evidenceCode": "ECO:0000313", "source": "ZFIN", "id": "ZDB-GENE-070912-34"}], "value": "si:ch211-122l24.6"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AB32TZ50"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "23594743", "citationType": "journal article", "authoringGroup": ["Genome Reference Consortium Zebrafish"], "authors": ["Howe K.", "Clark M.D.", "Torroja C.F.", "Torrance J.", "Berthelot C.", "Muffato M.", "Collins J.E.", "Humphray S.", "McLaren K.", "Matthews L.", "McLaren S.", "Sealy I.", "Caccamo M.", "Churcher C.", "Scott C.", "Barrett J.C.", "Koch R.", "Rauch G.J.", "White S.", "Chow W.", "Kilian B.", "Quintais L.T.", "Guerra-Assuncao J.A.", "Zhou Y.", "Gu Y.", "Yen J.", "Vogel J.H.", "Eyre T.", "Redmond S.", "Banerjee R.", "Chi J.", "Fu B.", "Langley E.", "Maguire S.F.", "Laird G.K.", "Lloyd D.", "Kenyon E.", "Donaldson S.", "Sehra H.", "Almeida-King J.", "Loveland J.", "Trevanion S.", "Jones M.", "Quail M.", "Willey D.", "Hunt A.", "Burton J.", "Sims S.", "McLay K.", "Plumb B.", "Davis J.", "Clee C.", "Oliver K.", "Clark R.", "Riddle C.", "Elliot D.", "Eliott D.", "Threadgold G.", "Harden G.", "Ware D.", "Begum S.", "Mortimore B.", "Mortimer B.", "Kerry G.", "Heath P.", "Phillimore B.", "Tracey A.", "Corby N.", "Dunn M.", "Johnson C.", "Wood J.", "Clark S.", "Pelan S.", "Griffiths G.", "Smith M.", "Glithero R.", "Howden P.", "Barker N.", "Lloyd C.", "Stevens C.", "Harley J.", "Holt K.", "Panagiotidis G.", "Lovell J.", "Beasley H.", "Henderson C.", "Gordon D.", "Auger K.", "Wright D.", "Collins J.", "Raisen C.", "Dyer L.", "Leung K.", "Robertson L.", "Ambridge K.", "Leongamornlert D.", "McGuire S.", "Gilderthorp R.", "Griffiths C.", "Manthravadi D.", "Nichol S.", "Barker G.", "Whitehead S.", "Kay M.", "Brown J.", "Murnane C.", "Gray E.", "Humphries M.", "Sycamore N.", "Barker D.", "Saunders D.", "Wallis J.", "Babbage A.", "Hammond S.", "Mashreghi-Mohammadi M.", "Barr L.", "Martin S.", "Wray P.", "Ellington A.", "Matthews N.", "Ellwood M.", "Woodmansey R.", "Clark G.", "Cooper J.", "Cooper J.", "Tromans A.", "Grafham D.", "Skuce C.", "Pandian R.", "Andrews R.", "Harrison E.", "Kimberley A.", "Garnett J.", "Fosker N.", "Hall R.", "Garner P.", "Kelly D.", "Bird C.", "Palmer S.", "Gehring I.", "Berger A.", "Dooley C.M.", "Ersan-Urun Z.", "Eser C.", "Geiger H.", "Geisler M.", "Karotki L.", "Kirn A.", "Konantz J.", "Konantz M.", "Oberlander M.", "Rudolph-Geiger S.", "Teucke M.", "Lanz C.", "Raddatz G.", "Osoegawa K.", "Zhu B.", "Rapp A.", "Widaa S.", "Langford C.", "Yang F.", "Schuster S.C.", "Carter N.P.", "Harrow J.", "Ning Z.", "Herrero J.", "Searle S.M.", "Enright A.", "Geisler R.", "Plasterk R.H.", "Lee C.", "Westerfield M.", "de Jong P.J.", "Zon L.I.", "Postlethwait J.H.", "Nusslein-Volhard C.", "Hubbard T.J.", "Roest Crollius H.", "Rogers J.", "Stemple D.L."], "citationCrossReferences": [{"database": "PubMed", "id": "23594743"}, {"database": "DOI", "id": "10.1038/nature12111"}], "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "publicationDate": "2013", "journal": "Nature", "firstPage": "498", "lastPage": "503", "volume": "496"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FT6AD0HQEQTFJ", "citationType": "submission", "authoringGroup": ["RefSeq"], "publicationDate": "APR-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080317.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068080317.1"}]}], "uniProtKBCrossReferences": [{"database": "RefSeq", "id": "XP_068080317.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_068224216.1"}]}, {"database": "GeneID", "id": "557261", "properties": [{"key": "Description", "value": "-"}]}, {"database": "ZFIN", "id": "ZDB-GENE-070912-34", "properties": [{"key": "GeneName", "value": "si:ch211-122l24.6"}]}, {"database": "Proteomes", "id": "UP000000437", "properties": [{"key": "Component", "value": "Chromosome 2"}]}], "sequence": {"value": "MGSFLSIPVTQKPEIYELPSQVQRDDDEIFQEFNENICKTMRRQNLRSRQELNLLNAYRRNWSSVVEKLMKKYPKWSSEDILNLRYRYEIVAKRYGYLLHFCNLRSRHAHGSGGPGEAASFDLWPTHTMPSVPCPGPFPGSFEKCERAESGSSTVHLAGPGPVGRGVCPSTWSKQRQSFTVDRSPKIGLKNFNGFRQMGANWSKVEVRIGGGKQMDCRRSRVSEPR", "length": 226, "molWeight": 25844, "crc64": "BEA05B46ECCFD1A2", "md5": "B615BBB24ABB2A351932BBA4B99F41BF"}, "extraAttributes": {"uniParcId": "UPI0035A1872C"}, "cluster_size": 3, "family": "Danionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHE8", "uniProtkbId": "A0AAQ5BHE8_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519372.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519372.1"}], "value": "Endoglin"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519372.1"}], "value": "ENG"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044712418"}, {"type": "Region", "location": {"start": {"value": 168, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHE8"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHE8"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519372.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15164053", "citationType": "journal article", "authors": ["Humphray S.J.", "Oliver K.", "Hunt A.R.", "Plumb R.W.", "Loveland J.E.", "Howe K.L.", "Andrews T.D.", "Searle S.", "Hunt S.E.", "Scott C.E.", "Jones M.C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Ashwell R.I.", "Babbage A.K.", "Babbage S.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beasley H.", "Beasley O.", "Bird C.P.", "Bray-Allen S.", "Brown A.J.", "Brown J.Y.", "Burford D.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Chen Y.", "Clarke G.", "Clark S.Y.", "Clee C.M.", "Clegg S.", "Collier R.E.", "Corby N.", "Crosier M.", "Cummings A.T.", "Davies J.", "Dhami P.", "Dunn M.", "Dutta I.", "Dyer L.W.", "Earthrowl M.E.", "Faulkner L.", "Fleming C.J.", "Frankish A.", "Frankland J.A.", "French L.", "Fricker D.G.", "Garner P.", "Garnett J.", "Ghori J.", "Gilbert J.G.", "Glison C.", "Grafham D.V.", "Gribble S.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Guy J.", "Hall R.E.", "Hammond S.", "Harley J.L.", "Harrison E.S.", "Hart E.A.", "Heath P.D.", "Henderson C.D.", "Hopkins B.L.", "Howard P.J.", "Howden P.J.", "Huckle E.", "Johnson C.", "Johnson D.", "Joy A.A.", "Kay M.", "Keenan S.", "Kershaw J.K.", "Kimberley A.M.", "King A.", "Knights A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.", "Lloyd D.M.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "McLaren S.", "McLay K.E.", "McMurray A.", "Milne S.", "Nickerson T.", "Nisbett J.", "Nordsiek G.", "Pearce A.V.", "Peck A.I.", "Porter K.M.", "Pandian R.", "Pelan S.", "Phillimore B.", "Povey S.", "Ramsey Y.", "Rand V.", "Scharfe M.", "Sehra H.K.", "Shownkeen R.", "Sims S.K.", "Skuce C.D.", "Smith M.", "Steward C.A.", "Swarbreck D.", "Sycamore N.", "Tester J.", "Thorpe A.", "Tracey A.", "Tromans A.", "Thomas D.W.", "Wall M.", "Wallis J.M.", "West A.P.", "Whitehead S.L.", "Willey D.L.", "Williams S.A.", "Wilming L.", "Wray P.W.", "Young L.", "Ashurst J.L.", "Coulson A.", "Blocker H.", "Durbin R.", "Sulston J.E.", "Hubbard T.", "Jackson M.J.", "Bentley D.R.", "Beck S.", "Rogers J.", "Dunham I."], "citationCrossReferences": [{"database": "PubMed", "id": "15164053"}, {"database": "DOI", "id": "10.1038/nature02465"}], "title": "DNA sequence and analysis of human chromosome 9.", "publicationDate": "2004", "journal": "Nature", "firstPage": "369", "lastPage": "374", "volume": "429"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519372.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519372.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519372.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL157935", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AL162586", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000462196.2", "properties": [{"key": "ProteinId", "value": "ENSP00000519251.1"}, {"key": "GeneId", "value": "ENSG00000106991.15"}]}, {"database": "Ensembl", "id": "ENST00000714081.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519372.1"}, {"key": "GeneId", "value": "ENSG00000106991.15"}]}, {"database": "HGNC", "id": "HGNC:3349", "properties": [{"key": "GeneName", "value": "ENG"}]}, {"database": "OpenTargets", "id": "ENSG00000106991", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00530000063861", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 9"}]}, {"database": "PROSITE", "id": "PS51257", "properties": [{"key": "EntryName", "value": "PROKAR_LIPOPROTEIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYAGSTHHMLGVRVTLACQDPVMGPGPSTKSDKSLSVRTTCQALCKDGQEFQPGHLPRAPGGQHHRAAILPQDPDP", "length": 194, "molWeight": 20591, "crc64": "5C6B6AD39E36C90C", "md5": "69D1648AE50E2D44A3A6137F8CA4F2EF"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1}, "uniParcId": "UPI0032CB3BB7"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LPM4", "uniProtkbId": "A0AAN0LPM4_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34086.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34086.1"}], "value": "Glutamate ionotropic [NMDA] receptor 3A"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 235, "modifier": "EXACT"}, "end": {"value": 253, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1167, "modifier": "EXACT"}, "end": {"value": 1187, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1207, "modifier": "EXACT"}, "end": {"value": 1227, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1239, "modifier": "EXACT"}, "end": {"value": 1259, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1418, "modifier": "EXACT"}, "end": {"value": 1444, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 1041, "modifier": "EXACT"}, "end": {"value": 1397, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00079"}]}, {"type": "Domain", "location": {"start": {"value": 1051, "modifier": "EXACT"}, "end": {"value": 1114, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor L-glutamate and glycine-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00918"}]}, {"type": "Coiled coil", "location": {"start": {"value": 1870, "modifier": "EXACT"}, "end": {"value": 1897, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Binding site", "location": {"start": {"value": 1125, "modifier": "EXACT"}, "end": {"value": 1125, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 1130, "modifier": "EXACT"}, "end": {"value": 1130, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 1291, "modifier": "EXACT"}, "end": {"value": 1291, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 1332, "modifier": "EXACT"}, "end": {"value": 1332, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Site", "location": {"start": {"value": 1270, "modifier": "EXACT"}, "end": {"value": 1270, "modifier": "EXACT"}}, "description": "Crucial to convey clamshell closure to channel opening", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1346, "modifier": "EXACT"}, "end": {"value": 1400, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34086.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34086.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155012", "properties": [{"key": "ProteinId", "value": "WRW34086.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043226", "properties": [{"key": "GoTerm", "value": "C:organelle"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0038023", "properties": [{"key": "GoTerm", "value": "F:signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000078", "properties": [{"key": "EntryName", "value": "glutamate receptor ionotropic, NMDA 3B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000324", "properties": [{"key": "EntryName", "value": "Predicted protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR001508", "properties": [{"key": "EntryName", "value": "Iono_Glu_rcpt_met"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00177", "properties": [{"key": "EntryName", "value": "NMDARECEPTOR"}]}, {"database": "SMART", "id": "SM00918", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNENSINQKMFNSEKNLCNEKIFDIKENLVKKKLFISQENFLMNRNMNENVLDKNFYLNTEKNISESSSSKSNSKLKTNLKNDSLINPLSKNLNSYRNSIIRNFISSNNDLTNNNSTNNSTITKDSSNNPKLANLNFPNDNSINKLSNFNKNSNSNETSIDKSDIKNKISKSKTFSDFTYEDIDDNFYSNNCENFYKYCKIVNEKKFICRPMPRKEVIKPKKLKPNTRKNKWKQCFDFFNPFFLISVFFYLLYCELTAVRGEILNSNITFLNKEFFLINNSSNEKIYSLDDFYKQINNSKLEKKNFFGKTRNDNFKIDNLPIFKVLAILPTIHTPEISKHFYRAIELNNALKENLVSNLELAHYFDHLKYPYRSQTELSSSLHHLQNNQNFYLNKTFENFAKFNENYLQNKKLFLNLNHSELSYEDHLYIHLLQRIYRRNHTNIETNNFFYPNSKNYENNQSPDNKINFLSKIQTSLLPLGNSSQRLINSFCDTAEIQRPSLILSLVEPTRSYYLEMLARITEIPLLTLSGEYMETASLQNILLEGKISETSMQLSLDPPISALADATFQLLKTQHWFDAILLIDDTSASDLFSYRLSQLCRQNDHRSKMFYQNKFSRYDEQTKHSTFSFMKDKFENEDGIRNYNRKEFNEDNYEFIDSIWTRLKIIRVSKNLLQKELYLQLSEIQTNHRRVVLVHCDKVTTKRVITTSKTLGLLDGSKIWVLLDGVIGSHIDTAEFLYEMNLPVGMLALHQRAPSLQDAQTLFNIVRIIGETAANTLLNAKDWMYEGSFSNGSQPEVSCWQKATSARIKYSQVVYQELKKIMKQFLYINHNKSKCKTTAKENFSTDKLNEKTVNLSSLKQISNEDLNKNFSVNQFPKTINRIKRHKTLKKRNNYYFDNDKNNEDPLVEKLKEMWPTPVFDVLNLVPNINSKVKANQTYKLTSSFLNNLLPKIALKSGLIQTKNYWKVIGNISDSNSTINSIKFITGKSGDRVIGPGSSSKHNFRIVSAISPPFVQHSTKLINGTCLTGIPCLKVNSSEPEDLVSVFTDFNSKIRRFEGKTYTVLCCEGISIDLLNSIARDLHFSYEMYLVADGLFGLPRKINRWDGITGDLISGSAHMAFSAFSITSARVQVIDFSVPFFYSGVSCLAQQRTSDVPLTAFLIPFSIQLWVAIFSSLLLTAIASATYEFMSPYGLNPHRGRQRTKNFSIGSAFWVMFSILFSHLYAFKAPKSWPNKVLLNLWGCFSVIFLATYTANVAAQFAGLFNTHEINNFNDGILMEKKVGVARSSASEGYIMKENMQLWSHVQKNRVNNLEEGIQLLRENKIEVLIGDTAILDYFRANEPGCNFNLLGDSIFDDAYAIGMQRNFPLKDAISDLIMEYNAYGFLDQLQRRWYGRAPCLENSLSNLRKPKPLSVRALAGVFIMLFIGMCIGVLILIGEHFLFKYGIPRLRKKSKDCFWKSPNLMFFSQKLYRFINSVELVSPHHSAKEIMSSLKTGQITTLFQKSLKRKAKEDARRRKSKYQFFEMIQEVRNVVKERKKNDPCIVGDSSINYPLKQDSFFSETDSIGNQTTIRTSSIKWKEETSNNSNSNLRNEYSAAKIREHQQFKSSLNNKARQGSVHTQQSAKELRSTIILHNEKKINSIDKTKNKNVSENLIDKQKENLNKNISKVKHSHNILKCLNNLDIPENFYKSQSSNLSSEFLSDKNCLLRVASGGQINQPHLHYENKSNYNCNLNEKVQHINLHSNISISLEDITLPGDSGSGIGFIKREDSSLVNKNFKKTLSFDDLTTLKKQLNYCVNSNDTENNSLNISNCNLMMMEDNSARNSMRSLILSSISPLRNYNYSKFDTVQNSNLSKEDIVSLWKNSERELLNNLHNILMQKKNLEEKCNLLQRMLTKNSY", "length": 1903, "molWeight": 219536, "crc64": "8239ADAE89DA8703", "md5": "2A35875807C5A6FDA565F0A51CFDD53E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 5, "Domain": 2, "Coiled coil": 1, "Binding site": 4, "Site": 1, "Disulfide bond": 1}, "uniParcId": "UPI00324C5619"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI30", "uniProtkbId": "A0AA96MI30_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50024.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02221"}], "value": "MD-2-related lipid-recognition domain-containing protein"}}}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 193, "modifier": "EXACT"}}, "description": "MD-2-related lipid-recognition domain-containing protein", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041676436"}, {"type": "Domain", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 190, "modifier": "EXACT"}}, "description": "MD-2-related lipid-recognition", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02221"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50024.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460101", "properties": [{"key": "ProteinId", "value": "WNS50024.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.60.40.770", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR014756", "properties": [{"key": "EntryName", "value": "Ig_E-set"}]}, {"database": "InterPro", "id": "IPR003172", "properties": [{"key": "EntryName", "value": "ML_dom"}]}, {"database": "Pfam", "id": "PF02221", "properties": [{"key": "EntryName", "value": "E1_DerP2_DerF2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81296", "properties": [{"key": "EntryName", "value": "E set domains"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MMSFTKTTFVCLCVSLIVVRGFNQPNWERKFDSKAPFEFTDQEKNLDSAHPQLWQTLADVHSITIKKLTVCAKAEDKLVLKNPPSISPMTIKPGGTVEIHVLATLKENVTGGEIKMAVLFYQKSVDLCAALAVSGVVKCPVSAGTFNYVQTPLKFQVPGNLKIPITGEFNIKLTVSDSKGQELTCLGLDIVIN", "length": 193, "molWeight": 21129, "crc64": "FACAE3E94817DCD1", "md5": "A29F647DE2C958E9648C0AA42B921A0C"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B2E9881"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BIE2", "uniProtkbId": "A0AAQ5BIE2_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520033.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520033.1"}], "value": "YY1 associated protein 1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520033.1"}], "value": "YY1AP1"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BIE2"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520033.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520033.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520033.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520033.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL162734", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "BX088689", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BIE2", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714832.1", "properties": [{"key": "ProteinId", "value": "ENSP00000520033.1"}, {"key": "GeneId", "value": "ENSG00000163374.21"}]}, {"database": "HGNC", "id": "HGNC:30935", "properties": [{"key": "GeneName", "value": "YY1AP1"}]}, {"database": "OpenTargets", "id": "ENSG00000163374", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000016256", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR052435", "properties": [{"key": "EntryName", "value": "YY1-Transcr_Regul"}]}, {"database": "PANTHER", "id": "PTHR16088:SF3", "properties": [{"key": "EntryName", "value": "GON-4-LIKE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR16088", "properties": [{"key": "EntryName", "value": "YY1 ASSOCIATED PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEDLFETHVQLLTQIHLLATCNPNLNPEASSTRICLKELGTFAQSSIALHHQYNPKFQTLFQPCNLMGAMQLIEDFSTHVSIDCSPHKTVKKTGRRQMCQL", "length": 101, "molWeight": 11470, "crc64": "EDCF28A7481DED2E", "md5": "61C5DC2D34CCC517DC6C1EB27FCDF597"}, "extraAttributes": {"uniParcId": "UPI0032CCFCC5"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZET1", "uniProtkbId": "A0AB38ZET1_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02766.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02766.1"}], "value": "Venom cystatin 7"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 120, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044231294"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02766.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517516", "properties": [{"key": "ProteinId", "value": "WXI02766.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004869", "properties": [{"key": "GoTerm", "value": "F:cysteine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00042", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.450.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000010", "properties": [{"key": "EntryName", "value": "Cystatin_dom"}]}, {"database": "InterPro", "id": "IPR046350", "properties": [{"key": "EntryName", "value": "Cystatin_sf"}]}, {"database": "SUPFAM", "id": "SSF54403", "properties": [{"key": "EntryName", "value": "Cystatin/monellin"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFKSAVIILLLGSVFLLECNAANIKLQPKGPHKVIKPGGVVDISVDDELMKKSLNFLLSERNSGLEVARVISAKRQTTNGYHYIIIFKTTGGQKCKANFTVRGSGDKMKLLSKNRGDILC", "length": 120, "molWeight": 13151, "crc64": "EDE9783CC83DBDEC", "md5": "95837E1C595A44FF36F08875ABBC48E4"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C2AFB"}, "cluster_size": 2, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7BBB6", "uniProtkbId": "A0AAU7BBB6_9NEOB", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Dyscophus guineti", "commonName": "Sambava tomato frog", "taxonId": 111069, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44905.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Microhyloidea", "Microhylidae", "Dyscophinae", "Dyscophus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44905.1"}], "value": "PRIT domain-containing protein"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 3243, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043952475"}, {"type": "Domain", "location": {"start": {"value": 189, "modifier": "EXACT"}, "end": {"value": 478, "modifier": "EXACT"}}, "description": "IgGFc-binding protein N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF17517"}]}, {"type": "Domain", "location": {"start": {"value": 2092, "modifier": "EXACT"}, "end": {"value": 2380, "modifier": "EXACT"}}, "description": "IgGFc-binding protein N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF17517"}]}, {"type": "Domain", "location": {"start": {"value": 2740, "modifier": "EXACT"}, "end": {"value": 3026, "modifier": "EXACT"}}, "description": "IgGFc-binding protein N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF17517"}]}, {"type": "Region", "location": {"start": {"value": 2431, "modifier": "EXACT"}, "end": {"value": 2457, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 2441, "modifier": "EXACT"}, "end": {"value": 2457, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9LKRFH5MKF7BD", "citationType": "submission", "authors": ["Zaman S.", "Roelants K."], "title": "Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.", "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44905.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR483821", "properties": [{"key": "ProteinId", "value": "XBE44905.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR035234", "properties": [{"key": "EntryName", "value": "IgGFc-bd_N"}]}, {"database": "PANTHER", "id": "PTHR46534", "properties": [{"key": "EntryName", "value": "IGGFC_BINDING DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46534:SF2", "properties": [{"key": "EntryName", "value": "VWFD DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF17517", "properties": [{"key": "EntryName", "value": "IgGFc_binding"}, {"key": "MatchStatus", "value": "3"}]}], "sequence": {"value": "MGWIMGPALWLSALLLCGGIQQAQAQYICRCFDPQAYLRLQGLFPEDTXGAGTMILPKGEKLGTGKWKFPRPIPYEGWKSEGIPGGGVPWMSFGTYDPPTKGKEFVTSFLPNNNNKEPSKTELLVTGTKDNTRLSITSAKMNLKRELKVGKGETVRVPIPPEVGSEPVVIKSPSDVTVMSSSYKGDSGDMSVVLPSDSLGREYYVMTPALGPPNEYKQVSVISQAAPTTVKISVTGTVTHKGKTYKKGDIIKENLDPYQAITIQSKDDLSGTKVESSQPVAVTVGHTCAEGNIGCNQVYEQSTPVETWGSRYYVPSHSSPPNSDTAYVMAPKKTAIQYTSGTEKVYKIVEAGKPLKIKVDKTSPLSLISREKFQVMLHGKGGIYKGKPSGSYLSSVPPISKYALKYTPVTQDNFNNIGMIMAKTTSTPEITVDGERPKDMKWNPFPGTDYSWAKYDFGPKYASHTVQHPNVPFGLMLNGYGDKAAYGTVAPSTIGGGIPEIPGVPGQIITGEIPGKPKIPGVPWQIITREIPGKPEIPGTPGQIITGEIPGKPKIPGTPGQIITGEIPGRPEIPGVSGQIITWEIPGKPKIPGTPGQIITGEIPGRPEIPGTPGQIITGEIPGKPTIPGTPGQIITGEIPGRPEIPGTPGQIITGEIPGKPKIPGTPGQIITGEIPGRPEIPGTPGQIITGEIPGKPKIPGTPGQIITGEIPGRPEIPGTPGQIITGEIPGKPKIPGTPGQIITGEIPGKPXIPGTPGQIITGEIPVTXGYPGVSEQIVTEKIPVTPGYPGVPEQIVTEKIPVTPGYPGVPEQIVTEKIPGRPSIPGVPGQIITGEIPGRPAIXGVPGQIITGEIPGRPAIPGVPGQIITGEIPGRPAIPGVPGQIITGEIPGTPEIPGVPGQIITGEIPGRYGVPGAPGWLPQEFELKGMKPWMTIGTYDPPTKGKEFVTSFLPNNKNNKEPSKMELLVTGTEDDTRFSITSPKIKFDKEARVGKDETVRVPIPPEVGSEPVVIKSPSDITVMSSSYKGDSGDMSVVCHPIIWEGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTIPGEPGQIITGEIPGRPAIPGEPGQIITGEIPGRPAIPGEPGQIITGEIPGRPAIPGEPGQIITWRIPGRPAIPGEPRWFPQESELKGMKPWMTIGTYDPPTKGKQFVTSFLPNKNNKEPSKTELLVTGTKDNTRFFITSDKTNLKKEARVGKDETVRVPIPPEVGSEPVVIKSRSDITVMSSSYKGDSGDMSAILPVDSLGKEYYVMTPALGAPDQYKQVSVISDEAPTTVKISVTGTVTHKGKTYKKGDIIKENLDPYQAITIQSKDDLSGTKVMSSRPVAVIAGQTCAKGNIGCNQGYEQSIPVEKWGSRYYVPSHSSPPNSDTAYVMAPKKTAIQYTSGTEKVYKIVEAGEPLKIKVDKTSPLSIISREKFQVMLHGKGGIYKGKPSGSYLSSVPDISKYGLKFNPVSQDNFNNIGMIMAKTTSTPEITVDGERPKDMKWNPFPGTEYSWAEYDFGTKFASHTVKHPSVPFGLMLNGYGDKTAYGTVAPSTIGGIPEIPEVPGQIITGEIPGMPEIPGKPGQIITVEKPGRPGIPGRPGQIITEEIPGRPEIPGIPRQIITVEKPGRPGIPGKPGQIITVEKPGRPGIPGRPGQIITVEKPGRPGIPGKPGQIITVKKPGRPGIPGKPGQIITVKKPGRPGIPGKPGQIITVKKPGRPGIPGKPGQIITVKKPGRPGIPGKPGQIITIEKPGRPGIPGKPGQIITIEKPGRPGIPGEPGWQFQWKGMKPGMSWMSIGSLGAPTKGKDFATAFLPNNNNNKPSKMEVLVTGTEDNTPVSITSSQANFKKEMKVRKGQTVRIPIPAKVGSQPVVIKSPKDITVMSSSYKGNSGDVAINLPFNLWGNEYYVITPALGPPNQYKQFIVITYSSPATVNVYVRGTVVYEGKTYVKGDVITVSMAPFQTILFQSKDNISGTRVFSSSNVGVMVGHSCAQDNNGCNNVFEQIDSVPRWGSTFFVASTSSKPNFDTVYVMAAKKTTIQYTSGTAKMNKNVEAGELFQINIDQSSPLFLSSPDGLQVLLHGKGGKFNNKPFGSFLSLIPDTMKYGLKYNLITKSNFINWAVIIAKTESGFGITFNGKRPKGIKWNKFPGTEYSWAVYNLGLKHASYIVQHPSDPFGLLSIGYGDNAAYGTLASCILGASGATWSKEWKFGTGPLSKWKFGGLKFPFKPRIAVLKPTKTFHWEGKVSIGTKGVSTKKGKGGHGFIPHIKKAFGWGVSTKKGKGGHGFLPHVKKAFGWKGKVSIGTKGGKGVHARKQFKLGVVPPGHAKKAFGWGGKFSIGTKAVSLGKGKGIHAGKQFKLGVVPPGHDRKAFGWGGKFSIGTKAGLKTTRGHHQLTYRS", "length": 3243, "molWeight": 349598, "crc64": "8B9F805C363C7D76", "md5": "263A4F5A6D748EAAEBA5D1E16D44DC52"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 3, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D3C27F"}, "cluster_size": 1, "family": "Microhylidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7N4D1", "uniProtkbId": "A0AAU7N4D1_GLOAC", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Glomerella acutata", "commonName": "Colletotrichum acutatum", "taxonId": 27357, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ83517.1"}], "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Pezizomycotina", "Sordariomycetes", "Hypocreomycetidae", "Glomerellales", "Glomerellaceae", "Colletotrichum", "Colletotrichum acutatum species complex"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ83517.1"}], "value": "Key lime anthracnose pathogenicity protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ83517.1"}], "value": "KLAP1"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ83517.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 103, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ83517.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EQTL7RJ3JAI99", "citationType": "submission", "authors": ["Zambounis A.", "Angeli C.", "Tsalgatidou P.", "Delis C."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ83517.1"}], "value": "FAth24.1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ83517.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP897736", "properties": [{"key": "ProteinId", "value": "XBQ83517.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "EVGMNPLDFLAAQDESIPSPAMVPPPQNFLTPYDGRNSQASLINSVCPSMSSGTSAAETLPLTRENSSFDNQSLSGAFGMTRINSAHSQGAADFMSPEVYAVP", "length": 103, "molWeight": 10824, "crc64": "DDA0297C4EDE9FA3", "md5": "255524111228EA6722D67FC4AE39B027"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D33259"}, "cluster_size": 3, "family": "Glomerellaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8BD56", "uniProtkbId": "A0AAU8BD56_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Conopomorpha sinensis", "commonName": "litch fruit borer", "taxonId": 940481, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD10486.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Tineoidea", "Gracillariidae", "Conopomorpha"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD10486.1"}], "value": "PBAN-type neuropeptides-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007714"}], "value": "Belongs to the pyrokinin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043347214"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022815"}], "id": "KW-0027", "category": "PTM", "name": "Amidation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022702"}], "id": "KW-0372", "category": "Molecular function", "name": "Hormone"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023320"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD10486.1"}], "id": "KW-0527", "category": "Molecular function", "name": "Neuropeptide"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5PCR16OJ21JA0", "citationType": "submission", "authors": ["Chang H."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD10486.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP937559", "properties": [{"key": "ProteinId", "value": "XCD10486.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005184", "properties": [{"key": "GoTerm", "value": "F:neuropeptide hormone activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007218", "properties": [{"key": "GoTerm", "value": "P:neuropeptide signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0042811", "properties": [{"key": "GoTerm", "value": "P:pheromone biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR008730", "properties": [{"key": "EntryName", "value": "PBAN"}]}, {"database": "InterPro", "id": "IPR001484", "properties": [{"key": "EntryName", "value": "Pyrokinin_CS"}]}, {"database": "Pfam", "id": "PF05874", "properties": [{"key": "EntryName", "value": "PBAN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00539", "properties": [{"key": "EntryName", "value": "PYROKININ"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFQKIFDSIVFLIILQLASDLVVADDFNIKEDNMERDARDRTGMWFGPRLGKRSVSLDTDKNDAFVRMLEAADVMKYYYDQLPSAYDAPRDLDSGNTVIFTPKLGRGADEKRREVDFTPRLGRRRVPEKIITHEIEKDDVRRELLVPSYFLRHMSPLERQFTPRLGRNMFDVFPEINKRVARSVEKRTLNKTST", "length": 194, "molWeight": 22735, "crc64": "8CC53934471A87B0", "md5": "440849264B786B14ED3D23113D3453BC"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D3CEC3"}, "cluster_size": 1, "family": "Gracillariidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2F5", "uniProtkbId": "A0AA96S2F5_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50028.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50028.1"}], "value": "Tenascin-X-like protein 2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Single-pass type I membrane protein", "id": "SL-9905"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 170, "modifier": "EXACT"}, "end": {"value": 256, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 257, "modifier": "EXACT"}, "end": {"value": 358, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Domain", "location": {"start": {"value": 450, "modifier": "EXACT"}, "end": {"value": 540, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50028.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460105", "properties": [{"key": "ProteinId", "value": "WNS50028.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "CDD", "id": "cd00063", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "InterPro", "id": "IPR003961", "properties": [{"key": "EntryName", "value": "FN3_dom"}]}, {"database": "InterPro", "id": "IPR036116", "properties": [{"key": "EntryName", "value": "FN3_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR050713", "properties": [{"key": "EntryName", "value": "RTP_Phos/Ushers"}]}, {"database": "PANTHER", "id": "PTHR46957", "properties": [{"key": "EntryName", "value": "CYTOKINE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46957:SF3", "properties": [{"key": "EntryName", "value": "CYTOKINE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00041", "properties": [{"key": "EntryName", "value": "fn3"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PRINTS", "id": "PR00014", "properties": [{"key": "EntryName", "value": "FNTYPEIII"}]}, {"database": "SMART", "id": "SM00060", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SUPFAM", "id": "SSF49265", "properties": [{"key": "EntryName", "value": "Fibronectin type III"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50853", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "3"}]}], "sequence": {"value": "MTKDEGELIEANIKATSVTLYHLLGKDVDYRCNVLTETSTDQFNITGGVRNTLSGLSADTTHTVNCVAYRGGVEYCLEATTTFRTSPVATVTDATSTSVDYYLEFGLSYNCTLLGKDNKVTATHKNVDLEKRQTFHGLTPGQNYSIRCSNRYRVFSVNTTFTTLEAPASEPMNLEGTAASSSQIRLTWQQPDYPNGVITSYVITYNEVQVDTNTASLGYTMTGLQPFTTYNISVASRNGAGVGEESREIGVKTRPGVPGAPTIARNISTTCQSLQISWTPPANTGGDEIMYYTVTYYVSGAVKNYINHTVYDIVVNAALVTLDELTPNTEYTVLVRASNSEQTGEAANTSVRTDSRDSISQRIIPFSSTGIIVAITPPPLQNIIGKAYTYSLSFVPNHLRVSPYNTSTTFQIFNGLQANTEYKVTSLVYRNGKGLCYEGMATGTTLPDTPPSRVRNLIVTRVTSTTIELRWERPEMTNGPITSYLIYYNGVQEDTSNVSLEYNLTGLQPFTTYNIGVAAKNGAGVGEESPAEITATTLEGVPGKVLKLRTVGVAVRGEPYITQPIAWERPPGHMSILEYVITISNTKTSQIAEALTNQTSFNLSLPTPRDCIDYNVSVAARSAVGQGEAASITVKYGGDGVTYNCSLALSQSHPAAASTYHTSSENGLFISSLRANTEYIVICTVSKGEQELCYEGTATGRTP", "length": 703, "molWeight": 76179, "crc64": "00876642DB3EF344", "md5": "EAB28A74B28A00C29555056D3770411D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3}, "uniParcId": "UPI002B299881"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU85", "uniProtkbId": "A0AAT9UU85_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41675.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41675.1"}], "value": "Cytochrome P450 3638D1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 34, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 81, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 460, "modifier": "EXACT"}, "end": {"value": 460, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41675.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117235", "properties": [{"key": "ProteinId", "value": "WIM41675.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTNALKNMSSGSQWSLLIIIYTLSFFTIWYIFVYKWRTRRITRMLKPFTKVPALPIIGSLHLVSGNMRERMIKFFDLLNKYEFPLVAWLFHTPIIFVGSYKDIQTVLNNTHERDTFGIFKRALGGSISLLQGETWRKHRRAMTPAFSNYMLQQYLHVFNEQSASLAKKLKQLADNDEAFDIWKYVVNMNVDIITQNMTGHKLQLQEKGTTKFSEALFKSLWLESSRFTSPLLFPDFIYSVYLFVTGNGKCFKTIYEFSRQIVQDRLAQYNKEKKIQQPQNNDDEGMKGPKTLIDLLVKVHDMDPEFTTEHMRAELLNMITLGSDTSSLTVSFVLLMLAMHPEVQEKVYDEIKTVFGDEDRVVEPGDLKHLVYLEQCIRETLRKYNVLPATARKPSQDIVLSDKRVIPGGCHVIVAFHAAHLDREIFPNPETWDPEHFASDSVASQNRQVSFPFGAGLRSCIGARYAMISIKTQLVHLLRDYRFTTNMKMDDIQVIVDLVLRNDTGYWLKLWSRKKNKQEIEA", "length": 522, "molWeight": 60646, "crc64": "2556153981A69E8D", "md5": "747E63191FE7F3ECF93734B73013C181"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 2, "Binding site": 1}, "uniParcId": "UPI0035D2A037"}, "cluster_size": 5, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA94YIJ2", "uniProtkbId": "A0AA94YIJ2_9FLOR", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Eucheuma denticulatum", "taxonId": 305493, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UXP11857.1"}], "lineage": ["Eukaryota", "Rhodophyta", "Florideophyceae", "Rhodymeniophycidae", "Gigartinales", "Solieriaceae", "Eucheuma"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012468"}], "value": "glutathione gamma-glutamylcysteinyltransferase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012468"}], "value": "2.3.2.15"}]}}, "features": [{"type": "Domain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 219, "modifier": "EXACT"}}, "description": "Peptidase C83", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51443"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UXP11857.1"}], "id": "KW-0012", "category": "Molecular function", "name": "Acyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022539"}], "id": "KW-0104", "category": "Ligand", "name": "Cadmium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UXP11857.1"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EJL3AL4AGJEKL", "citationType": "submission", "authors": ["Othman R.", "Murthy S."], "title": "Functional characterisation of phytochelatin synthase from Eucheuma denticulatum (Rhodophyta).", "publicationDate": "JUN-2021", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UXP11857.1"}], "value": "Thallus", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UXP11857.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "MZ420718", "properties": [{"key": "ProteinId", "value": "UXP11857.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016756", "properties": [{"key": "GoTerm", "value": "F:glutathione gamma-glutamylcysteinyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0046938", "properties": [{"key": "GoTerm", "value": "P:phytochelatin biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0010038", "properties": [{"key": "GoTerm", "value": "P:response to metal ion"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.90.70.30:FF:000001", "properties": [{"key": "EntryName", "value": "Glutathione gamma-glutamylcysteinyltransferase 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.90.70.30", "properties": [{"key": "EntryName", "value": "Phytochelatin synthase, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR038765", "properties": [{"key": "EntryName", "value": "Papain-like_cys_pep_sf"}]}, {"database": "InterPro", "id": "IPR040409", "properties": [{"key": "EntryName", "value": "PCS-like"}]}, {"database": "InterPro", "id": "IPR007719", "properties": [{"key": "EntryName", "value": "PCS_N"}]}, {"database": "InterPro", "id": "IPR038156", "properties": [{"key": "EntryName", "value": "PCS_N_sf"}]}, {"database": "PANTHER", "id": "PTHR33447", "properties": [{"key": "EntryName", "value": "GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF05023", "properties": [{"key": "EntryName", "value": "Phytochelatin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54001", "properties": [{"key": "EntryName", "value": "Cysteine proteinases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51443", "properties": [{"key": "EntryName", "value": "PCS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTKPTNPNPEEPDTSPPTHQKSFYRRPLPSNLVDFNSAEGKSRFSSALEAGHAETFFPLISQFQTQSHPALCGLTTLSTILNALQIDPKRVWNHPWRWFAESLLDCCLNMEDMKTEGITMDQLACTAACQGSTVRALRGLSAQDARDMIRDSARGNADGSFEFIVAAYDRQALGQTGTGHFSPIAAYDHASDSVLVLDVARFKVSSVFRFLLASCNRSL", "length": 219, "molWeight": 24132, "crc64": "50774097FD26A5C8", "md5": "51EDF04E010139C673ABD75BAE0D7DFA"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1}, "uniParcId": "UPI002B2A959B"}, "cluster_size": 1, "family": "Solieriaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6ND80", "uniProtkbId": "A0AAU6ND80_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59824.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59824.1"}], "value": "OR94a"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 49, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 86, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59824.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 131, "modifier": "EXACT"}, "end": {"value": 131, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59824.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59824.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420184", "properties": [{"key": "ProteinId", "value": "WWA59824.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "GPLFNQKKPEHREFLLEAIRQAKVLLRGFNIAAVFTCLLWALYPVILYVQRKPVEFAIWLPFDANLSPQFYFAIFYVWVQTSWLAFSNTSMDAFATSFLVQSKAQLSILRLDLEHVVEKSKEEAVETSGDF", "length": 131, "molWeight": 15152, "crc64": "906E31EB419A355D", "md5": "51D01D4795F486B6C1259884399E686A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 2}, "uniParcId": "UPI0035D2E696"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEB0", "uniProtkbId": "A0AB38ZEB0_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71761.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "value": "Metalloendopeptidase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "value": "3.4.24.-"}]}}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Zn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29105"}}], "note": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "value": "Binds 1 zinc ion per subunit."}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}]}, {"type": "Chain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 280, "modifier": "EXACT"}}, "description": "Metalloendopeptidase", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "featureId": "PRO_5044045632"}, {"type": "Domain", "location": {"start": {"value": 72, "modifier": "EXACT"}, "end": {"value": 276, "modifier": "EXACT"}}, "description": "Peptidase M12A", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51864"}]}, {"type": "Active site", "location": {"start": {"value": 172, "modifier": "EXACT"}, "end": {"value": 172, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}]}, {"type": "Binding site", "location": {"start": {"value": 171, "modifier": "EXACT"}, "end": {"value": 171, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 175, "modifier": "EXACT"}, "end": {"value": 175, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 181, "modifier": "EXACT"}, "end": {"value": 181, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "note": "catalytic"}}, {"type": "Disulfide bond", "location": {"start": {"value": 138, "modifier": "EXACT"}, "end": {"value": 160, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023049"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0482", "category": "Molecular function", "name": "Metalloprotease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71761.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510836", "properties": [{"key": "ProteinId", "value": "WXH71761.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004222", "properties": [{"key": "GoTerm", "value": "F:metalloendopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd04280", "properties": [{"key": "EntryName", "value": "ZnMc_astacin_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.390.10", "properties": [{"key": "EntryName", "value": "Collagenase (Catalytic Domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR034035", "properties": [{"key": "EntryName", "value": "Astacin-like_dom"}]}, {"database": "InterPro", "id": "IPR024079", "properties": [{"key": "EntryName", "value": "MetalloPept_cat_dom_sf"}]}, {"database": "InterPro", "id": "IPR001506", "properties": [{"key": "EntryName", "value": "Peptidase_M12A"}]}, {"database": "InterPro", "id": "IPR006026", "properties": [{"key": "EntryName", "value": "Peptidase_Metallo"}]}, {"database": "PANTHER", "id": "PTHR10127", "properties": [{"key": "EntryName", "value": "DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10127:SF780", "properties": [{"key": "EntryName", "value": "METALLOENDOPEPTIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01400", "properties": [{"key": "EntryName", "value": "Astacin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00480", "properties": [{"key": "EntryName", "value": "ASTACIN"}]}, {"database": "SMART", "id": "SM00235", "properties": [{"key": "EntryName", "value": "ZnMc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55486", "properties": [{"key": "EntryName", "value": "Metalloproteases ('zincins'), catalytic domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51864", "properties": [{"key": "EntryName", "value": "ASTACIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLGSLYVAVLLATALSLPIKQEEDINEGYQLVCPKDKKGCYVIGHQEISEDKLFEGDVIPFDVGDGGDESRNALINMKRRWPKNTVPYVFHAEFSAKSKELIIKSMRFIESKTCIKFEEFDPELGHTHILFITNDRGCRATTGFERRQKMHLLNLNEAGCINMLRVGKIHHEMLHVLGLKHEHSRPDRDEYVTIVKKNISPEKMHNFIKANPKEYTTYGVPYNYLSVMHYPSVAFSIDNKSPTIVPKNNVDHTLLGQRKKAADSDLEKINIMYKCPKEEN", "length": 280, "molWeight": 32121, "crc64": "DB3B45FC75D901E6", "md5": "0719D8AE68930A7C8D9AA403950CB149"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Active site": 1, "Binding site": 3, "Disulfide bond": 1}, "uniParcId": "UPI00388BF062"}, "cluster_size": 5, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38Z7E5", "uniProtkbId": "A0AB38Z7E5_PAESU", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia suffruticosa", "commonName": "Tree peony", "synonyms": ["Paeonia moutan"], "taxonId": 45171, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20332.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20332.1"}], "value": "Glycosyltransferase 2 family"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004308"}], "value": "Endomembrane system", "id": "SL-0147"}}]}], "features": [{"type": "Region", "location": {"start": {"value": 141, "modifier": "EXACT"}, "end": {"value": 161, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 452, "modifier": "EXACT"}, "end": {"value": 452, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:58885"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR605150-2"}], "ligand": {"name": "UDP-alpha-D-glucose", "id": "ChEBI:CHEBI:58885"}}, {"type": "Binding site", "location": {"start": {"value": 453, "modifier": "EXACT"}, "end": {"value": 453, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29035"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR605150-3"}], "ligand": {"name": "Mn(2+)", "id": "ChEBI:CHEBI:29035"}}, {"type": "Binding site", "location": {"start": {"value": 477, "modifier": "EXACT"}, "end": {"value": 477, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29035"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR605150-3"}], "ligand": {"name": "Mn(2+)", "id": "ChEBI:CHEBI:29035"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023316"}], "id": "KW-0961", "category": "Biological process", "name": "Cell wall biogenesis/degradation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-67NUCHPS7RPVN", "citationType": "submission", "authors": ["Zhang Y.", "Gai S."], "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20332.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR237917", "properties": [{"key": "ProteinId", "value": "WRI20332.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0012505", "properties": [{"key": "GoTerm", "value": "C:endomembrane system"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016760", "properties": [{"key": "GoTerm", "value": "F:cellulose synthase (UDP-forming) activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0071555", "properties": [{"key": "GoTerm", "value": "P:cell wall organization"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0030244", "properties": [{"key": "GoTerm", "value": "P:cellulose biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.1190.20", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005150", "properties": [{"key": "EntryName", "value": "Cellulose_synth"}]}, {"database": "InterPro", "id": "IPR029056", "properties": [{"key": "EntryName", "value": "Ribokinase-like"}]}, {"database": "PANTHER", "id": "PTHR13301", "properties": [{"key": "EntryName", "value": "X-BOX TRANSCRIPTION FACTOR-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03552", "properties": [{"key": "EntryName", "value": "Cellulose_synt"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53613", "properties": [{"key": "EntryName", "value": "Ribokinase-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAPGRNRNKLKYVAHRTTLVQVEVNTDGEPNGIQSDTGTHTFWAWQSVLLRNHLRYPLNEAIHWKQYPIKYKDLLWLEMQENAEKNLDNRVDHPHPNHHMGSRGYPALTTLMILAAELENRALPDDFEIWNRFDEKVIEFTNEDESTPESQRPTSTPRHRAWDFVNDEKNSTKHRLGKGSGPTITMLSGIQKFVNEEMITKLRPTQHELQMTKEDLSTTQLKVNEDNLKVNEDKMSKMQAFLEAKFSSQSIQRGLEFFLFSKAKDHINLKIDVFDLAGIWVAFYRKYGIEPRNPEAYFGQKCDFLKNKVRLDFVREGRQVKRKYDEFKVGINSLPESIRRRSDAYNAHEELRQKKKQMEMGDNLSDPIKVLKGTWMSDGSHWPGTWSSVETDHSRGDHAGIIQTMLAPPNAEPVFGTEADGENLIDTTEVDTRLPMLVYVSREKRPGYDHNKKVRAMNALVRTSAIMSNGPFILNLDCDHYIYNSMALREGMCFMLDWGGNRIRYVQFLQGIYPSDRYANHNIVSFDVSMRALDGLQGPINSTTLAASIPVVEYQGRLLQDLQGKGNQGRLAGSLAVPREPLDAVTVAEAIMHFPALPASVVRLTGASDCLVGGALAALCVGLDVLQSVAVGVTAAKAAVELEPNEHLQSEGELTRLLQLLEELNDSHYWGDGCTRVIFYYVLPHFVKTTKLEVDLTSINIKTIEDIARMMMAILSWLPNSSSILEALLMNMEELEDLKFFYHEHLLWLQ", "length": 750, "molWeight": 85449, "crc64": "54E60A10CC7C873F", "md5": "13B7319CC691410A691D7B539C1DD777"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Region": 1, "Binding site": 3}, "uniParcId": "UPI00388BF1B9"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7NIL0", "uniProtkbId": "A0AAU7NIL0_MARVT", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maruca vitrata", "commonName": "Bean pod borer moth", "taxonId": 497515, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96830.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Maruca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012109"}], "value": "unspecific monooxygenase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012109"}], "value": "1.14.14.1"}]}}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003690"}], "value": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:17149"}, {"database": "Rhea", "id": "RHEA-COMP:11964"}, {"database": "Rhea", "id": "RHEA-COMP:11965"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:15379"}, {"database": "ChEBI", "id": "CHEBI:30879"}, {"database": "ChEBI", "id": "CHEBI:57618"}, {"database": "ChEBI", "id": "CHEBI:58210"}, {"database": "ChEBI", "id": "CHEBI:142491"}], "ecNumber": "1.14.14.1", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047827"}]}}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 221, "modifier": "EXACT"}, "end": {"value": 221, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1RJQRMRFQ0KB6", "citationType": "submission", "authors": ["Esmaeily M.", "Kim Y."], "title": "C18 oxylipin, EpOME, mediates the immune resolution at late infection stage in the legume pod borer, Maruca vitrata.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96830.1"}], "value": "7", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96830.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP905475", "properties": [{"key": "ProteinId", "value": "XBR96830.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292:SF84", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 28A5-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNLSPWLSRKLKIKLFSEYEEFFIGAVKKIIRQREHESGQKHDFADICVNLQRSRTLKDRETGLEMEPTDELLAGLAFFFFSAGVDPSAAAIFGCLLELGRHPDHLEKVHVEIDSTFEALNGKFPYESVMDMGYLEMVLCESLRLWPPIGFLGRQCVEDTVLPVGNIKIEKGTKVFAAVYELHHDPKHYPDPEVFDPERFASEAARDSGVYMPFGKGNRLCVGMRFARR", "length": 229, "molWeight": 26131, "crc64": "C85926602EFBA93D", "md5": "EC0944F161FE727EB6FF43932118115C"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 1, "COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D2D86D"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7E2K7", "uniProtkbId": "A0AAU7E2K7_CUPSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Cupiennius salei", "commonName": "American wandering spider", "taxonId": 6928, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBH24427.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Araneae", "Araneomorphae", "Entelegynae", "Lycosoidea", "Ctenidae", "Cupiennius"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361235"}], "value": "Carboxylic ester hydrolase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361235"}], "value": "3.1.1.-"}]}}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "acetylcholine + H2O = choline + acetate + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:17561"}, {"database": "ChEBI", "id": "CHEBI:15354"}, {"database": "ChEBI", "id": "CHEBI:15355"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:30089"}], "ecNumber": "3.1.1.7", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00048484"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005964"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361235"}], "value": "Belongs to the type-B carboxylesterase/lipase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361235"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 566, "modifier": "EXACT"}}, "description": "Carboxylic ester hydrolase", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361235"}], "featureId": "PRO_5043100549"}, {"type": "Domain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 530, "modifier": "EXACT"}}, "description": "Carboxylesterase type B", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00135"}]}, {"type": "Active site", "location": {"start": {"value": 213, "modifier": "EXACT"}, "end": {"value": 213, "modifier": "EXACT"}}, "description": "Acyl-ester intermediate", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR600997-1"}]}, {"type": "Active site", "location": {"start": {"value": 344, "modifier": "EXACT"}, "end": {"value": 344, "modifier": "EXACT"}}, "description": "Charge relay system", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR600997-1"}]}, {"type": "Active site", "location": {"start": {"value": 461, "modifier": "EXACT"}, "end": {"value": 461, "modifier": "EXACT"}}, "description": "Charge relay system", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR600997-1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361235"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022867"}], "id": "KW-0531", "category": "Biological process", "name": "Neurotransmitter degradation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022487"}], "id": "KW-0719", "category": "Molecular function", "name": "Serine esterase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361235"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BO23AKJ3U52CJ", "citationType": "submission", "authors": ["Liu H.", "Jang J.", "French A.S.", "Torkkeli P.H."], "title": "Expression and Characterization of Seven Acetylcholine esterases in the Spider Cupiennius salei.", "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBH24427.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP836381", "properties": [{"key": "ProteinId", "value": "XBH24427.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0003990", "properties": [{"key": "GoTerm", "value": "F:acetylcholinesterase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006581", "properties": [{"key": "GoTerm", "value": "P:acetylcholine catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0019695", "properties": [{"key": "GoTerm", "value": "P:choline metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "3.40.50.1820:FF:000029", "properties": [{"key": "EntryName", "value": "Acetylcholinesterase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.1820", "properties": [{"key": "EntryName", "value": "alpha/beta hydrolase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR029058", "properties": [{"key": "EntryName", "value": "AB_hydrolase_fold"}]}, {"database": "InterPro", "id": "IPR050654", "properties": [{"key": "EntryName", "value": "AChE-related_enzymes"}]}, {"database": "InterPro", "id": "IPR002018", "properties": [{"key": "EntryName", "value": "CarbesteraseB"}]}, {"database": "InterPro", "id": "IPR019826", "properties": [{"key": "EntryName", "value": "Carboxylesterase_B_AS"}]}, {"database": "InterPro", "id": "IPR019819", "properties": [{"key": "EntryName", "value": "Carboxylesterase_B_CS"}]}, {"database": "InterPro", "id": "IPR000997", "properties": [{"key": "EntryName", "value": "Cholinesterase"}]}, {"database": "PANTHER", "id": "PTHR43918", "properties": [{"key": "EntryName", "value": "ACETYLCHOLINESTERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43918:SF4", "properties": [{"key": "EntryName", "value": "CARBOXYLIC ESTER HYDROLASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00135", "properties": [{"key": "EntryName", "value": "COesterase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00878", "properties": [{"key": "EntryName", "value": "CHOLNESTRASE"}]}, {"database": "SUPFAM", "id": "SSF53474", "properties": [{"key": "EntryName", "value": "alpha/beta-Hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00122", "properties": [{"key": "EntryName", "value": "CARBOXYLESTERASE_B_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00941", "properties": [{"key": "EntryName", "value": "CARBOXYLESTERASE_B_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYCLGLLEMHLIVLIASLFKISSSELIVETSSGPIRGTAALSDDVEAFLGIPYAEPPVGDLRFAKPVPKKRWDKILDASTLPPPCVQFSMGPYYFMPDITNMSEDCLYLNIWNPKAESNHGLRPVIIYIHPGAFCTGGTNMKVYDGSRLASLGDVVVVTINYRLGVLGYFLAYNEVANGNMGMYDQITAMKWIKSNAKNFGGDPENIVLMGISAGAFSAAAHVISPLSNNLFRRAILQSGGMVHPYFMDDNARLYRNSELMSSVVGCANETVSLKSDPRAVVKCLKEKPKEILANAELLLMKSNPINFYPRVNDEFLPKSSVAFLREGKFRKDINVIIGVNKDEGGLFLTTGLPDYFGLYGKVSLNVINKYRAALISRGFSMVAGEPRPSELVDFYIKNVKNRTSTGYTKMVSNFIGDYMIACNTIFFADFLSLKGNVVYFYKFEYRSTSTPIAEWMGTTHLDDVPYVFGNPFHENFTAEEEELSNRLIARWSAFAKTGNPNIPGHVPWLRYSYHNPLFLSFGQEEESIRLKPIDRCEVWRERFGAAFDADSIRRLRNSAMNITFP", "length": 566, "molWeight": 63388, "crc64": "9CE1F779C3020FFD", "md5": "49700B25DF4AD576E1F0DBB9E0071DFF"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Active site": 3}, "uniParcId": "UPI0035D2DAAF"}, "cluster_size": 2, "family": "Ctenidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJH0", "uniProtkbId": "A0AAU7LJH0_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28221.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28221.1"}], "value": "MADS26"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28221.1"}], "value": "MADS26"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 36, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28221.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28221.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400861", "properties": [{"key": "ProteinId", "value": "XBP28221.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR11945:SF776", "properties": [{"key": "EntryName", "value": "AGAMOUS-LIKE 50-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11945", "properties": [{"key": "EntryName", "value": "MADS BOX PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGLFNKAAELNILTGAKVAAIVFSPHDKCFSFGTPNCKSVIDSYFHTTASASDDHHDRIMINNINDQNYNNDSIALSILENTNRLEEDRKMKMKKVDGFWWDSSIDHDNMSLNELMSYKNSLLNLKENVEKRAMDLLRISTYTT", "length": 144, "molWeight": 16470, "crc64": "D07A60BCF29286FA", "md5": "6F2095CF86FBADEDADFDF149FE16CC9E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D2854B"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAA9YHL4", "uniProtkbId": "A0AAA9YHL4_HUMAN", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518884.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518884.1"}], "value": "Adaptor related protein complex 4 subunit beta 1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518884.1"}], "value": "AP4B1"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAA9YHL4"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAA9YHL4"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518884.1"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518884.1"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518884.1"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518884.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL137856", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000489092.6", "properties": [{"key": "ProteinId", "value": "ENSP00000518884.1"}, {"key": "GeneId", "value": "ENSG00000134262.15"}]}, {"database": "HGNC", "id": "HGNC:572", "properties": [{"key": "GeneName", "value": "AP4B1"}]}, {"database": "OpenTargets", "id": "ENSG00000134262", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000157025", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}], "sequence": {"value": "MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRSGSPGHQYAVQRLLRPQSNGARAGVTEHV", "length": 67, "molWeight": 7579, "crc64": "76B2807B3031251F", "md5": "00379876D26736731F2C01CF14C92F69"}, "extraAttributes": {"uniParcId": "UPI00004DE60B"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEL7", "uniProtkbId": "A0AB38ZEL7_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02729.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02729.1"}], "value": "Venom S1 protease 21"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 406, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044329979"}, {"type": "Domain", "location": {"start": {"value": 162, "modifier": "EXACT"}, "end": {"value": 397, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022825"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023145"}], "id": "KW-0865", "category": "PTM", "name": "Zymogen"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02729.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517479", "properties": [{"key": "ProteinId", "value": "WXI02729.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00190", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.40.10.10:FF:000146", "properties": [{"key": "EntryName", "value": "Serine protease 53"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001314", "properties": [{"key": "EntryName", "value": "Peptidase_S1A"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR018114", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24258:SF116", "properties": [{"key": "EntryName", "value": "FI16631P1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24258", "properties": [{"key": "EntryName", "value": "SERINE PROTEASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00722", "properties": [{"key": "EntryName", "value": "CHYMOTRYPSIN"}]}, {"database": "SMART", "id": "SM00020", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00134", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNTYSWALILIWCSVTAHAASSDITMKTGEQKRLTHKTEDGLAETTWNLETCEGCRFIVSCYLYNKNCDEEQLIVFDGNRTTKECGPRFSATVIKNSVYNKMSITFKTKGHVDNCMCHVSTTKPYTNTPYEPEDSAEHGLGTGATKQPTCKCGWANKSPARIVGGHEVAPNQYPFVAYFKIKHDSRPLCGATIISPYHLLTAAHCTSGFEGMPLVGVVGDHDVTRNDETAFTQEIEVEQIINHENYDNDHLLHDIAIIVLKNQINFNDAVGPVCLPSARINLDGKYAKFMGWGNLRSKGQKSPVLRHVTVKGIPLDICSEVYRQGIDLTASKQHCTWAPGRDSCQGDSGGPLVWVNPEYNLYKQVGIVSFGSGCASMEPGVTTDVSYFKEWIEQVVARTKPHQLCE", "length": 406, "molWeight": 45023, "crc64": "C2A569830C412493", "md5": "E420E7BA03EDA0445D1C1512583AB715"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388C08D3"}, "cluster_size": 3, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MMH7", "uniProtkbId": "A0AA96MMH7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50096.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50096.1"}], "value": "Uncharacterized protein 24"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 189, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041696961"}, {"type": "Transmembrane", "location": {"start": {"value": 98, "modifier": "EXACT"}, "end": {"value": 119, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50096.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460173", "properties": [{"key": "ProteinId", "value": "WNS50096.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MMRKTSMLFILLVIASSAALSILGAEEEISGNDITPAELAAYTRVQGIDDIDNEEDNWMDNDDEMVLMEAVMSTANDDDDLQKELAGGLETGHVKQQFFGLGSVFSIARRLLPSIVRLFKRRKRRTRRYRRYRPSQRRYGRYRRRQERPCLTMQYLVQKVSVAIQRENALSISGSLSSLPDLDMDYVYF", "length": 189, "molWeight": 21812, "crc64": "B9F52C7B48A3F2F1", "md5": "37841144BAC0112B11D33ECC4E51AAAF"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1}, "uniParcId": "UPI002B304613"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9V4W8", "uniProtkbId": "A0AAT9V4W8_AEGLO", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Aegilops longissima", "commonName": "Goatgrass", "synonyms": ["Triticum longissimum"], "taxonId": 4486, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WJE88197.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Liliopsida", "Poales", "Poaceae", "BOP clade", "Pooideae", "Triticodae", "Triticeae", "Triticinae", "Aegilops"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012513"}], "value": "non-specific serine/threonine protein kinase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012513"}], "value": "2.7.11.1"}]}}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:17989"}, {"database": "Rhea", "id": "RHEA-COMP:9863"}, {"database": "Rhea", "id": "RHEA-COMP:11604"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:29999"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:83421"}, {"database": "ChEBI", "id": "CHEBI:456216"}], "ecNumber": "2.7.11.1", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00048679"}]}}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:46608"}, {"database": "Rhea", "id": "RHEA-COMP:11060"}, {"database": "Rhea", "id": "RHEA-COMP:11605"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:30013"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:61977"}, {"database": "ChEBI", "id": "CHEBI:456216"}], "ecNumber": "2.7.11.1", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047899"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000304"}], "value": "Belongs to the protein kinase superfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 214, "modifier": "EXACT"}, "end": {"value": 476, "modifier": "EXACT"}}, "description": "Protein kinase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50011"}]}, {"type": "Region", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 164, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 148, "modifier": "EXACT"}, "end": {"value": 164, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 242, "modifier": "EXACT"}, "end": {"value": 242, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022777"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WJE88197.1"}], "id": "KW-0418", "category": "Molecular function", "name": "Kinase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022527"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000304"}], "id": "KW-0723", "category": "Molecular function", "name": "Serine/threonine-protein kinase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EHAOMK3UA0H9A", "citationType": "submission", "authors": ["He H.", "Wang Y."], "title": "MLKL-K, a mixed lineage kinase-like domain-containing kinase gene, originated from Aegilops longissima confers resistance to wheat powdery mildew.", "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WJE88197.1"}], "value": "AE 417", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WJE88197.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR052514", "properties": [{"key": "ProteinId", "value": "WJE88197.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0004674", "properties": [{"key": "GoTerm", "value": "F:protein serine/threonine kinase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0007166", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd21037", "properties": [{"key": "EntryName", "value": "MLKL_NTD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.510.10:FF:001023", "properties": [{"key": "EntryName", "value": "Os07g0541700 protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.930.20", "properties": [{"key": "EntryName", "value": "Adaptor protein Cbl, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.510.10", "properties": [{"key": "EntryName", "value": "Transferase(Phosphotransferase) domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036537", "properties": [{"key": "EntryName", "value": "Adaptor_Cbl_N_dom_sf"}]}, {"database": "InterPro", "id": "IPR011009", "properties": [{"key": "EntryName", "value": "Kinase-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR054000", "properties": [{"key": "EntryName", "value": "MLKL_N"}]}, {"database": "InterPro", "id": "IPR000719", "properties": [{"key": "EntryName", "value": "Prot_kinase_dom"}]}, {"database": "InterPro", "id": "IPR017441", "properties": [{"key": "EntryName", "value": "Protein_kinase_ATP_BS"}]}, {"database": "InterPro", "id": "IPR008271", "properties": [{"key": "EntryName", "value": "Ser/Thr_kinase_AS"}]}, {"database": "PANTHER", "id": "PTHR45707", "properties": [{"key": "EntryName", "value": "C2 CALCIUM/LIPID-BINDING PLANT PHOSPHORIBOSYLTRANSFERASE FAMILY PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45707:SF43", "properties": [{"key": "EntryName", "value": "PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF22215", "properties": [{"key": "EntryName", "value": "MLKL_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00069", "properties": [{"key": "EntryName", "value": "Pkinase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00220", "properties": [{"key": "EntryName", "value": "S_TKc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56112", "properties": [{"key": "EntryName", "value": "Protein kinase-like (PK-like)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00107", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_ATP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50011", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00108", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_ST"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEAVGQGAAVAQLVGSTGTVGLIQRIIRATETARQNKRECQHLALRVSVIWELLPRLPLEPGLESPLKELGKTLGEAHKLILACQKRSTVGTFLKASRHAHSFREVNARIDSLLSLFPLIVASRLGRILPPDDHDGESITLTGPPPSSSYGSLQTQPYEDGESSQPWETVINTLLSSREMSDQVMELKALKGVLIDANAEPIRLSYPFLSSITGDFSREIGRGGFGIVYQGDIGTSKVAVKKLFISESFSDTLFVDEIKCLLKAKHNNVVRFLGYCADTHGKLASFNGNHVMSELPHRLLCFEYVPNGDLRKYLKDESHKDEWKIRYQMIRGICRGLNYLHGQRVNHLDLKPANILLDACMEPKIADFGLSRCFDEGISRVHTNVVRGTVGCIAPETINNGEITFKSDIYGLGIIIIKLLTRCNNCDFENWLTSLDMDHPRVMSLAEIAQTCVQMDQHKRPTICEIMQKLDEIESM", "length": 476, "molWeight": 53042, "crc64": "2A5B122778F1E926", "md5": "3E6C7C06CD405E8FB9512EFA3E3E1E71"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 2, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1, "Binding site": 1}, "uniParcId": "UPI0035D381ED"}, "cluster_size": 14, "family": "Poaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PB23", "uniProtkbId": "A0AAU6PB23_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20555.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20555.1"}], "value": "Venom peptide"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043694378"}, {"type": "Domain", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 102, "modifier": "EXACT"}}, "description": "Single", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM01318"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20555.1"}], "value": "U_LCTX_80_Cm23", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20555.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480824", "properties": [{"key": "ProteinId", "value": "WXB20555.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "InterPro", "id": "IPR029277", "properties": [{"key": "EntryName", "value": "SVWC_dom"}]}, {"database": "Pfam", "id": "PF15430", "properties": [{"key": "EntryName", "value": "SVWC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01318", "properties": [{"key": "EntryName", "value": "SVWC"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFRVICLLCGFLGSGLALVSFQPLQEKPQHFKHIPGCYIEALGNVMPKGTVMQRPGYCMQYHCEEKHYVIETCPDPVLRPGDKLVEQDRSLPYPSCCPKLVMGRMTTHDEF", "length": 111, "molWeight": 12632, "crc64": "21E91447D749C309", "md5": "3B00CFBD63BCFD7B7C817FDDFFFC83B2"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI0035D306CC"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEI1", "uniProtkbId": "A0AB38ZEI1_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02671.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02671.1"}], "value": "Venom redulysin 4"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 289, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044261996"}, {"type": "Coiled coil", "location": {"start": {"value": 51, "modifier": "EXACT"}, "end": {"value": 86, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 254, "modifier": "EXACT"}, "end": {"value": 285, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02671.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517421", "properties": [{"key": "ProteinId", "value": "WXI02671.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSKLWLLLLLVAAFQAVHSFPALDDEYLEDPAETTWSILKDTFNKLKDKYAENWNQLKEKSKENWAKLKEKSKEKYREMLSRIQNKLCTQQDVDLDFEEDDSNEVPLKVQILQKIRELLRKVKTAAGAEKEKLKQLIKDLTAKLCDRLSNDYEEDDDDMEEDPAESTWSILKQTFTKLKDKYKENWSKLKEKAKQNWSKLKEKTKEKYLEMVKRVKEKICTQQDVEEDMEFEEDTDFEEDEEGQKEVPLGVKLLNKLRELLRKIKSAIGDKKDKLKEEIQNIKAKFCSS", "length": 289, "molWeight": 34255, "crc64": "08B2B8610BF5C7FC", "md5": "E8A6497C626DB985246B6BAA69050724"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Coiled coil": 2}, "uniParcId": "UPI00388BDDA0"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7M6", "uniProtkbId": "A0AAN0N7M6_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65894.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65894.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65894.1"}], "value": "UGT"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009995"}], "value": "Belongs to the UDP-glycosyltransferase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 7, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65894.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145347", "properties": [{"key": "ProteinId", "value": "WRV65894.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050271", "properties": [{"key": "EntryName", "value": "UDP-glycosyltransferase"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48043", "properties": [{"key": "EntryName", "value": "EG:EG0003.4 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48043:SF145", "properties": [{"key": "EntryName", "value": "FI06409P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00201", "properties": [{"key": "EntryName", "value": "UDPGT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSEKKKILFYTYLSIGHLNVCSSIASILLDKYHDEIEINFLVDEIWAKKLSIIDSRFKFNIYEASKKNEEDLITKTIKKLEDSLNLPYFDRTIEIYKTFYEKPDDLVFTDEQISKIINELKPDYILCDLISQMPSVIGSKIPHSFIISCNPLVLDIEDFPSMGLFVNTDEKEKIKSMKQNLENAIKGPKEKYESIFDIMNVKYNKKYPMFSPRSDYLSIYCYPKELDYYDDEIKKKYKLLQIDSALVKSRIPAPFELPEKFVKLPGKIIYVSLGSLFSCYYEKLQKLINVLAKLPYKYIVSKGPNGDKIKFPDNRFIGENFINQLAVLQVVDMMVSHGGNNTFTECFYFGVPAIILPVMADQINNAKRIEETGFGYHINLVSYTEEELKNKINKVLLDDSLTEKMKKISERIKYENKLEKVAVEFYNSIKNIKKNI", "length": 436, "molWeight": 50801, "crc64": "C3270066689E5065", "md5": "BFC538E665D5ED172D56E3B9FFA9FF77"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI00324E8475"}, "cluster_size": 13, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEB6", "uniProtkbId": "A0AB38ZEB6_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71775.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71775.1"}], "value": "Venom CUB domain protein 3"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 190, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044299669"}, {"type": "Domain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 109, "modifier": "EXACT"}}, "description": "CUB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS01180"}]}, {"type": "Region", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 190, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 150, "modifier": "EXACT"}, "end": {"value": 166, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 181, "modifier": "EXACT"}, "end": {"value": 190, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 73, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 190, "modifier": "EXACT"}, "end": {"value": 190, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71775.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71775.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510850", "properties": [{"key": "ProteinId", "value": "WXH71775.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd00041", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.290", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000859", "properties": [{"key": "EntryName", "value": "CUB_dom"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "Pfam", "id": "PF00431", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01180", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSAVSLILLAVLSVIGSAKILQKRDVQNVDVDSPDYPTIPPPGTKIIWEITGEVNSNILLTCEDLRIAPSENCKNGYYLVNDGATEEKYCGTHSGLMIKSVKHQMKIIFDVYYTSGVAKCEVEGKDMNIVRKDESIDWGPNGEPGSDIGKPGGGTDEPGSGTGEPGSGTDEPGSGTGEPGSGTDEPGSGT", "length": 190, "molWeight": 19876, "crc64": "908EB6DC87B21183", "md5": "F76109F2000B4FE7F51EBA0759582B26"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 2, "Disulfide bond": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388BD6AE"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QL78", "uniProtkbId": "A0AAU0QL78_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56552.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56552.1"}], "value": "Odorant binding protein/PBP-general odorant binding protein"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008098"}], "value": "Belongs to the PBP/GOBP family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56552.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56552.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56552.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970291", "properties": [{"key": "ProteinId", "value": "WPO56552.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006072", "properties": [{"key": "EntryName", "value": "Odorant/phero-bd_Lep"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00484", "properties": [{"key": "EntryName", "value": "PBPGOBP"}]}, {"database": "SMART", "id": "SM00708", "properties": [{"key": "EntryName", "value": "PhBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "EFKHFWSEEFEVVHRELGCALICMSNKFSLLQEDTRIHHINMHDYVKSFPNGEALSAKMVELLHNCEKQYDSITDDCDRTVKVAACFKVDAKKEGIAPEITMIEAVMERY", "length": 110, "molWeight": 12785, "crc64": "2B81D114DF9FABD9", "md5": "751F8B2D8E43C156385A41DE4F3923A5"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0030883323"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96US83", "uniProtkbId": "A0AA96US83_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29079.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29079.1"}], "value": "CREWS-A3"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 935, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041667447"}, {"type": "Domain", "location": {"start": {"value": 31, "modifier": "EXACT"}, "end": {"value": 204, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 359, "modifier": "EXACT"}, "end": {"value": 532, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 555, "modifier": "EXACT"}, "end": {"value": 732, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 751, "modifier": "EXACT"}, "end": {"value": 924, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Region", "location": {"start": {"value": 260, "modifier": "EXACT"}, "end": {"value": 344, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 260, "modifier": "EXACT"}, "end": {"value": 331, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29079.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651416", "properties": [{"key": "ProteinId", "value": "WNX29079.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF20", "properties": [{"key": "EntryName", "value": "PH DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "4"}]}], "sequence": {"value": "MVLFPLLLLFLILRGSAPAATFNPTCTERSNVVFLVDTSNSTDEQDFKKELLYVQGLLDFFDVSPTTTRVAAISYSDDYEKKFGLNTHKTVDKVKEAVDKIKISESQDRNSHMAMKHAREILAAQGKGPNVGQPIIICFTTGSATDPDKVLKEAQKMQNKNIKLFVVHVGSEEEDTRLGDVAKVVTLPNEGDVSRQLNAIAAKICEGSETTEATTLEVTSPGITSPVVTTTEVTSPEVTSSVFTTPEVTSPVNTSVITTSEVTSPEVTSSEVTPSVVTSSEVTSPEVTPSVVTSSEVTSPEVTSPEVTTSVVTSPEVSSPVVTSHGVTSPVTTPPATSPPVVTTTTTKRPVVRCKRPADIVFLLDTSAYLRHIEFQLIKKFVQDMIGYFDVSPSATRVAVVSFSTTSKEEFGLGRYQSEDPMLKAVSNISFTDGGYTRGHKAIAHALTLLEPQPRDDAARIIIYVTASTSSPRDKTVKAAKKVRSKGILVFSVGIGHYVNAEELGQIATQNTTDFVHSVSTFPDLSRISESLGRQACKVPIPVVQPVPQCEQPFDLVFLVDTSGNIYDEEFPLLLEFVQDMIRQFDVSPQKTRVAVISYSKGTKEAFGLDKYQSSEPMLEAVGKIAFTNTGYLDSHDAIDDAYNLLSPKSRDDAVRAIIYIAHGGATKRDETFRIAEKVRNKGILMFTVGVGEHWTHKELDQIATENTAQFVHNVNYLEDLSALSETLGPEVCAAKAPIMEPVELCKHPVELVFLVDMSNSVNPSDFPFMMDFVIEVIELFDISPSTTRVAVVSFNEEHKEEFNLQKYSTVRELRKAVSQISFTGGGRTNPDLAIKHAREVILDDSRKDAGRVIISMIEGQPSDWSSTVQEADETRQEDIVMFAVGLGEEADEKKLEEIVFNGDEQYVYTAYNVTYLPEITKALGEKACSVSQLE", "length": 935, "molWeight": 102349, "crc64": "C77B8C9B1C168238", "md5": "9B34954CEB1FB43D572E18F30AF224FF"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 4, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B2D2A50"}, "cluster_size": 1, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8BSW0", "uniProtkbId": "A0AAU8BSW0_9BILA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Novocrania anomala", "taxonId": 317945, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD23094.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Brachiopoda", "Craniiformea", "Craniata", "Craniida", "Cranioidea", "Craniidae", "Novocrania"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD23094.1"}], "value": "Diarylamidine-activated Na+ channel"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD23094.1"}], "value": "DiaaNaC"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "value": "Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 71, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 482, "modifier": "EXACT"}, "end": {"value": 507, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 482, "modifier": "EXACT"}, "end": {"value": 500, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 519, "modifier": "EXACT"}, "end": {"value": 519, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD23094.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023053"}], "id": "KW-0915", "category": "Ligand", "name": "Sodium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022461"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0894", "category": "Molecular function", "name": "Sodium channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023201"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0739", "category": "Biological process", "name": "Sodium transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-76HL0R1OC4Q1Q", "citationType": "submission", "authors": ["Borve A.", "Marti-Solans J.", "Lynagh T.", "Hejnol A."], "title": "Diarylamidine Activation of a Brachiopod DEG/ENaC/ASIC Channel.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD23094.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP942623", "properties": [{"key": "ProteinId", "value": "XCD23094.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0015280", "properties": [{"key": "GoTerm", "value": "F:ligand-gated sodium channel activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.60.470.10", "properties": [{"key": "EntryName", "value": "Acid-sensing ion channels like domains"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.770", "properties": [{"key": "EntryName", "value": "YojJ-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001873", "properties": [{"key": "EntryName", "value": "ENaC"}]}, {"database": "InterPro", "id": "IPR020903", "properties": [{"key": "EntryName", "value": "ENaC_CS"}]}, {"database": "PANTHER", "id": "PTHR11690:SF222", "properties": [{"key": "EntryName", "value": "AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11690", "properties": [{"key": "EntryName", "value": "AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00858", "properties": [{"key": "EntryName", "value": "ASC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01078", "properties": [{"key": "EntryName", "value": "AMINACHANNEL"}]}, {"database": "PROSITE", "id": "PS01206", "properties": [{"key": "EntryName", "value": "ASC"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MESKQSSGSHRNSTCCPVKCTWHYERQFAETTTCHGVSHIVSSDRLWSKAIWSVFVCTAFVAVISQCWLLFSNYLHHHTVTEIRVLYEDRIEFPAVTVCNFNRLRKSVLEDWGIIDTDMREYLLAGFGAEGVLHGNLTFYPKTRHHRFLNISKTAGSKIPKDFEQVVRKAGTQFQDLITFCAFGGLPNFGVCADEAFQHTYTELGNCYTYKPKIPGYQYATGTNRGLTLGMFLRVEDYAETLFYGLIESGLRFHIHDPGEPPIMEGSGLSVAPGVHAYASIARTDFINLKDPWGECVNHSLTFFPKYTVQGCLLECKVKFIMSVCNCTPIAYPSVDGVPVCSPVEMLTCFYRKSIEFEFLKIQDTPCGISCDPACNYTEYDVALSYAELPGKSVAIEFAAEKNVTLEFLKKNYMELSVYFKDIKHTIIEQKKAQTPEGLISNIGGQLGLFLGASFLTLAEFGQYILIKLQHWCGTKDPDKKRKEALEKTKDNPSVDHRPVDTSQDNDCNNAKAAAVTYL", "length": 519, "molWeight": 58408, "crc64": "9D483C620E28557C", "md5": "92E85EE1418B7413FFDE1D14047D3D78"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D36864"}, "cluster_size": 1, "family": "Craniidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8KYK8", "uniProtkbId": "A0AAU8KYK8_HALDU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28587.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28587.1"}], "value": "Exportin-6"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009466"}], "value": "Belongs to the exportin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 35, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "Importin N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03810"}]}, {"type": "Domain", "location": {"start": {"value": 103, "modifier": "EXACT"}, "end": {"value": 275, "modifier": "EXACT"}}, "description": "Exportin-1/Importin-beta-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF08389"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022927"}], "id": "KW-0653", "category": "Biological process", "name": "Protein transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EGAS7BV8JDS8L", "citationType": "submission", "authors": ["Mikhailov K.", "Kravchuk O.", "Lyupina Y.", "Adameyko K."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28587.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP971921", "properties": [{"key": "ProteinId", "value": "XCN28587.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005049", "properties": [{"key": "GoTerm", "value": "F:nuclear export signal receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0031267", "properties": [{"key": "GoTerm", "value": "F:small GTPase binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006611", "properties": [{"key": "GoTerm", "value": "P:protein export from nucleus"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.25.10.10", "properties": [{"key": "EntryName", "value": "Leucine-rich Repeat Variant"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011989", "properties": [{"key": "EntryName", "value": "ARM-like"}]}, {"database": "InterPro", "id": "IPR016024", "properties": [{"key": "EntryName", "value": "ARM-type_fold"}]}, {"database": "InterPro", "id": "IPR013598", "properties": [{"key": "EntryName", "value": "Exportin-1/Importin-b-like"}]}, {"database": "InterPro", "id": "IPR001494", "properties": [{"key": "EntryName", "value": "Importin-beta_N"}]}, {"database": "InterPro", "id": "IPR040016", "properties": [{"key": "EntryName", "value": "XPO6"}]}, {"database": "PANTHER", "id": "PTHR21452", "properties": [{"key": "EntryName", "value": "EXPORTIN-6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21452:SF4", "properties": [{"key": "EntryName", "value": "EXPORTIN-6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03810", "properties": [{"key": "EntryName", "value": "IBN_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08389", "properties": [{"key": "EntryName", "value": "Xpo1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48371", "properties": [{"key": "EntryName", "value": "ARM repeat"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQSSEEDTLRQFEALLMEMFSGTCDNTRIREIGKMLDDFSCQPHSWKFCLYFLHQSQNSSVQMYSLNVLDKFITRLWPSVNAEDRLLVRQTLWVFLDKNPSVPSFIRSKVLTVIVVIVRLEWPHDYPDFFHTVYQLIRQDSTSSIGLSFLLTASEELVTPREGAISTTRKQELKDLLLQEAQSIVPLLLDVLRLQAQRHQCSSHSTLPSSPAPFLRTGSPSVPQSLGKIHSFTPFDAAAEEICSLCLRCLTHMSSWIPLRLFVTPAITEMLFYYVFLGCESENDCTDSAGILGHLALGCVNEILQQNFVPSEAEHFMMQIFERTFILLRKLTGASGGDLRTHYASLDDRYLGKCNEYLRLLVSSHLRRIDSNPNFPLTEFLSLFQDHTLKQPQVDSYYLCLEAWHVFLDHVITSRAASQEGRTSQDPSHLAKYKEPLMNLLEGLVKKILMDINTLELSELDDDRLDSDNETEWQCFVRQTTEIFALIAELFPMEAFQKLIPLLENFSVTFFQIKDHLYRQGKDLCIHLEGVDGKGLHARLRDLCTVLQMLGRLAEHLAEPHFLARFDLGNMLFDRFCCIAKFSSDHELYSVMLEESSDESFADFDSLDRTFMEVHAHSLGALNALCYSWLPTYHLCALRDSEPRCSDCAVKVEALCQLGLPLLVEQIPERISVSAGHMLVTLSHAVRPQQLTQLPLIQGFILQGSQGRFNQLPNLIGRLSYRIVSNIFVMPWPEVPTSQQHWDSRSHEFGKFIDGAMQSLLDIGKLDRFGERPEVVTQAEPLIVQSLSALEEMVAGVGSEGTRSTMVMYQAVEKIIDLSLVFFQHCLSNSRILSAVMSFFQTVFKNLKVQEKSGRTQTAVILTIMKLLDSQVFKEMLISNDPVSCNVMQKFLSILTDQVSTQSSFLKVELPNIITFCLEAVYTTVEKLPVPDVKLELYKLLAQILMHNWRYFFRSNILTRMEGEDDESVVCVGQFRAIMQIYLQSFMQPEIELFRENLTALQELNRRHSLFSKTIFKTDMLPLFVHVLLEVLVQKSHDLLGEDIGACLHAMACSSFQTFHREVLPSFLCKFPQLSQEQRDKLAQNYKLEEDLPSFLRNIHQLSCDLRYYFLLNASLKPLT", "length": 1120, "molWeight": 128238, "crc64": "0A07FA3885A46006", "md5": "E0BE213F17C5AB6BBCB28069B9CC9935"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2}, "uniParcId": "UPI0035D2C503"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTK2", "uniProtkbId": "A0AAT9UTK2_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41681.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41681.1"}], "value": "Cytochrome P450 3638F2"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 15, "modifier": "EXACT"}, "end": {"value": 34, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 461, "modifier": "EXACT"}, "end": {"value": 461, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41681.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117241", "properties": [{"key": "ProteinId", "value": "WIM41681.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTIMKTNILVFLHNTLGYGVGTIIIFGITFYFAFIRKRRTSKMMSMLQSFNQMPAIPIIGSLYLLMGNPRERTAKVIKAWNTYETPFVVWLMNTPLVCITEHEDTQEILNTSHHVEYLGTFEKFFRNSIQQSQGEKWRKSRQLASAAFSSTMMREYFTTVNEHSAILAKELEPLSDTDEVIDIKSYISMSNLNSTLRNFTGYKMYSSRKERVEFIDAISKAIQMESDRYTVPFLLPKIMYEAYLFLFRKRYVYDTMQNLAKKIVRERLATYNTKTNTPSEGTDQDTVATGPKLYIDLLLQRYNTDADITKEHVEDEVFGIIFGSLGTTSETVCFLSLMLAIHQEAQQKVYDEIEIICGDTDQEFQKEDLKKLVYLEQCVNETLRKFTIVPVDFRTHHEDIMLKNGQVIPAGCLVLLALYKIHHNKKFFPNADNWDPRHFDRERITQWRQSFFPFGSGPRLCVGSKYAMMSIKIQLVHLLRRYRLTTEMKMRDIHIVFGMVTQNDSGYRLKLHSRVKNERSDMSA", "length": 524, "molWeight": 61161, "crc64": "6F1AF5B166AB5247", "md5": "C0E3F1B1B53110A790F49B70E7D0426F"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D3210D"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BIC9", "uniProtkbId": "A0AAQ5BIC9_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520414.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520414.1"}], "value": "Uncharacterized protein"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 9, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BIC9"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520414.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520414.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15815621", "citationType": "journal article", "authors": ["Hillier L.W.", "Graves T.A.", "Fulton R.S.", "Fulton L.A.", "Pepin K.H.", "Minx P.", "Wagner-McPherson C.", "Layman D.", "Wylie K.", "Sekhon M.", "Becker M.C.", "Fewell G.A.", "Delehaunty K.D.", "Miner T.L.", "Nash W.E.", "Kremitzki C.", "Oddy L.", "Du H.", "Sun H.", "Bradshaw-Cordum H.", "Ali J.", "Carter J.", "Cordes M.", "Harris A.", "Isak A.", "van Brunt A.", "Nguyen C.", "Du F.", "Courtney L.", "Kalicki J.", "Ozersky P.", "Abbott S.", "Armstrong J.", "Belter E.A.", "Caruso L.", "Cedroni M.", "Cotton M.", "Davidson T.", "Desai A.", "Elliott G.", "Erb T.", "Fronick C.", "Gaige T.", "Haakenson W.", "Haglund K.", "Holmes A.", "Harkins R.", "Kim K.", "Kruchowski S.S.", "Strong C.M.", "Grewal N.", "Goyea E.", "Hou S.", "Levy A.", "Martinka S.", "Mead K.", "McLellan M.D.", "Meyer R.", "Randall-Maher J.", "Tomlinson C.", "Dauphin-Kohlberg S.", "Kozlowicz-Reilly A.", "Shah N.", "Swearengen-Shahid S.", "Snider J.", "Strong J.T.", "Thompson J.", "Yoakum M.", "Leonard S.", "Pearman C.", "Trani L.", "Radionenko M.", "Waligorski J.E.", "Wang C.", "Rock S.M.", "Tin-Wollam A.M.", "Maupin R.", "Latreille P.", "Wendl M.C.", "Yang S.P.", "Pohl C.", "Wallis J.W.", "Spieth J.", "Bieri T.A.", "Berkowicz N.", "Nelson J.O.", "Osborne J.", "Ding L.", "Meyer R.", "Sabo A.", "Shotland Y.", "Sinha P.", "Wohldmann P.E.", "Cook L.L.", "Hickenbotham M.T.", "Eldred J.", "Williams D.", "Jones T.A.", "She X.", "Ciccarelli F.D.", "Izaurralde E.", "Taylor J.", "Schmutz J.", "Myers R.M.", "Cox D.R.", "Huang X.", "McPherson J.D.", "Mardis E.R.", "Clifton S.W.", "Warren W.C.", "Chinwalla A.T.", "Eddy S.R.", "Marra M.A.", "Ovcharenko I.", "Furey T.S.", "Miller W.", "Eichler E.E.", "Bork P.", "Suyama M.", "Torrents D.", "Waterston R.H.", "Wilson R.K."], "citationCrossReferences": [{"database": "PubMed", "id": "15815621"}, {"database": "DOI", "id": "10.1038/nature03466"}], "title": "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.", "publicationDate": "2005", "journal": "Nature", "firstPage": "724", "lastPage": "731", "volume": "434"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520414.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520414.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC096670", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "PeptideAtlas", "id": "A0AAQ5BIC9", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000715207.1", "properties": [{"key": "ProteinId", "value": "ENSP00000520414.1"}, {"key": "GeneId", "value": "ENSG00000293584.1"}]}, {"database": "GeneTree", "id": "ENSGT01130000282389", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 2"}]}], "sequence": {"value": "MSDSDSRTEKRKKKRPNGKATF", "length": 22, "molWeight": 2568, "crc64": "CFB91A84B23E2707", "md5": "19E6BB3853E58EA1FF437ABC5E63A71B"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0032C69A6C"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2Y5", "uniProtkbId": "A0AA96S2Y5_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50059.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50059.1"}], "value": "Peroxidasin-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 716, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041649354"}, {"type": "Region", "location": {"start": {"value": 188, "modifier": "EXACT"}, "end": {"value": 212, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 470, "modifier": "EXACT"}, "end": {"value": 470, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:60344"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR619791-2"}], "ligand": {"name": "heme b", "id": "ChEBI:CHEBI:60344"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR619791-2"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR619791-2"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR619791-2"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50059.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460136", "properties": [{"key": "ProteinId", "value": "WNS50059.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004601", "properties": [{"key": "GoTerm", "value": "F:peroxidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006979", "properties": [{"key": "GoTerm", "value": "P:response to oxidative stress"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd09823", "properties": [{"key": "EntryName", "value": "peroxinectin_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.640.10:FF:000003", "properties": [{"key": "EntryName", "value": "chorion peroxidase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.640.10", "properties": [{"key": "EntryName", "value": "Haem peroxidase domain superfamily, animal type"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR019791", "properties": [{"key": "EntryName", "value": "Haem_peroxidase_animal"}]}, {"database": "InterPro", "id": "IPR010255", "properties": [{"key": "EntryName", "value": "Haem_peroxidase_sf"}]}, {"database": "InterPro", "id": "IPR037120", "properties": [{"key": "EntryName", "value": "Haem_peroxidase_sf_animal"}]}, {"database": "PANTHER", "id": "PTHR11475:SF4", "properties": [{"key": "EntryName", "value": "CHORION PEROXIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11475", "properties": [{"key": "EntryName", "value": "OXIDASE/PEROXIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03098", "properties": [{"key": "EntryName", "value": "An_peroxidase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00457", "properties": [{"key": "EntryName", "value": "ANPEROXIDASE"}]}, {"database": "SUPFAM", "id": "SSF48113", "properties": [{"key": "EntryName", "value": "Heme-dependent peroxidases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50292", "properties": [{"key": "EntryName", "value": "PEROXIDASE_3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPRLVAALSALLVLCHIGAGADFAAPRAFEVRLSALLADADARATTLLQDGMRGALRPGRDRRETADWGSAAELHRIMGLPQPMAQGMVHAALAAEMAQANFSSLVHSDPFFREAASDARLQRMAREQITQHCKDVRKEKSCSKVQKMLRKYLPEFDLSKHHAFSGACNNLKHRSYGSTPMPLGRMLGAAYDQPESSPRSTGAGGQPLPGSREVSNSLCFGSQDQDQIFTMMGVTWGQLLDHDVDLTCAGNFDKNQSCSGICGSSQETKACFPIAVATSDTELGCRAGNCIPMARSCPACIKGQGSREQINQITSYHDASNVYGGPFGAGDTYWKGLADLTTGKMRVQKSSSNTDLLPQATGNPDSCDGTCFQGGDARANEVPVLTAFHTIWVREHNRLVPALKSINPTWTPTKLYLEARKIVTALHQHITYAEFVPLLLGSPLESYKYCPETDASTANVFATASFRYAHSAITENFNLADDQYMPLTPLSVVDGYFDTTHIRSPGALDNLLRGMAVQKAFKVDTKFSDSLRNRMFESSHGDCGLDLLSLNIQRGRDHGLPSYNKWRQLVRGRCQLTSGTVHSFDDLKSEMSSQSLASLKAVYDDVDDIDLYAGGLAETAYAPSGVVGPTFWCLNKIQLENFRKGDRLFYENPGVFSYDQVTEIKKMTLATIICRNSDDITRMPEHVMRVDSRSTFVDCAGLPEMDLRMWKEGSSC", "length": 716, "molWeight": 78525, "crc64": "BCABABA37FA72307", "md5": "3EBF3FCBC361D02A54ACC9CD588DA46F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1, "Binding site": 1}, "uniParcId": "UPI002B319FEB"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0Z4H4", "uniProtkbId": "A0AAF0Z4H4_HIRNI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hirudo nipponia", "commonName": "Korean blood-sucking leech", "taxonId": 42736, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49277.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Hirudinea", "Hirudinida", "Hirudiniformes", "Hirudinidae", "Hirudo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0008006", "source": "Google", "id": "ProtNLM"}], "value": "F5/8 type C domain-containing protein"}}}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 470, "modifier": "EXACT"}}, "description": "F5/8 type C domain-containing protein", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042245631"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-ANPA6HQVADV17", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49277.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR759983", "properties": [{"key": "ProteinId", "value": "WPD49277.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.60.120.260", "properties": [{"key": "EntryName", "value": "Galactose-binding domain-like"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR051941", "properties": [{"key": "EntryName", "value": "BG_Antigen-Binding_Lectin"}]}, {"database": "InterPro", "id": "IPR008979", "properties": [{"key": "EntryName", "value": "Galactose-bd-like_sf"}]}, {"database": "PANTHER", "id": "PTHR45713:SF15", "properties": [{"key": "EntryName", "value": "F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45713", "properties": [{"key": "EntryName", "value": "FTP DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF22633", "properties": [{"key": "EntryName", "value": "F5_F8_type_C_2"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SUPFAM", "id": "SSF49785", "properties": [{"key": "EntryName", "value": "Galactose-binding domain-like"}, {"key": "MatchStatus", "value": "3"}]}], "sequence": {"value": "MRLIISLLFLWCLCSASRAFNEIPLSKKHVRQGEVTRKGHDATLAIDGDLSTFSLAEGKETWWMIDLLKTYQISQVIITASHDAENAKYLQSFSIWLEDEKSNRDLCYEYTSTESLVPSETRSFPCKAHNFQTRFVKINTDGTNEQNKLVLAEVTIIWGLPMSQIFCSGDEITLIDETHNENANKQKKNLAIDKNVATFSLAESSDINSFAWLQVDLGELYDVGEVILTADDKYYNQSLQNFAIRLHGEHNSVQNCKDYKSGKNLAPRETRPFRCEGASFQTRFVRIERIGGFKQNLLAIAEVKVKTRSSPVTIFPNSEFGIEIPLAGNLVTLMGAEERDHVGNLATDGNVNSFAVVKTESSTGLWWQVDLEGNYHVGEVILTASIKQEYANCLHNFTIWLVNEKLERHFCNHYKLSEYFRKQETRSFVCEKDMFVARYIRIEKHGDSRPDTLALAEVAAFSGFSRRIVL", "length": 470, "molWeight": 53474, "crc64": "0976866BEC5C8493", "md5": "58D4A4A9BDAC6CD4FC7F9298C9642A76"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B2ADE80"}, "cluster_size": 1, "family": "Hirudinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N666", "uniProtkbId": "A0AAJ6N666_9MONI", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leptochilus wrightii", "taxonId": 187345, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8D2J"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Polypodiopsida", "Polypodiidae", "Polypodiales", "Polypodiineae", "Polypodiaceae", "Microsoroideae", "Leptochilus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8D2J"}], "value": "IPD113_Cow"}}]}, "features": [{"type": "Disulfide bond", "location": {"start": {"value": 251, "modifier": "EXACT"}, "end": {"value": 256, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8D2J"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8D2J"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}], "references": [{"referenceNumber": 1, "citation": {"id": "37871210", "citationType": "journal article", "authors": ["Wei J.Z.", "Lum A.", "Schepers E.", "Liu L.", "Weston R.T.", "McGinness B.S.", "Heckert M.J.", "Xie W.", "Kassa A.", "Bruck D.", "Rauscher G.", "Kapka-Kitzman D.", "Mathis J.P.", "Zhao J.Z.", "Sethi A.", "Barry J.", "Lu A.L.", "Brugliera F.", "Lee E.L.", "van derWeerden N.L.", "Eswar N.", "Maher M.J.", "Anderson M.A."], "citationCrossReferences": [{"database": "PubMed", "id": "37871210"}, {"database": "DOI", "id": "10.1073/pnas.2306177120"}], "title": "Novel insecticidal proteins from ferns resemble insecticidal proteins from <i>Bacillus thuringiensis</i>.", "publicationDate": "2023", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "e2306177120", "lastPage": "e2306177120", "volume": "120"}, "referencePositions": ["X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS)", "DISULFIDE BONDS"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8D2J"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8D2J", "properties": [{"key": "Method", "value": "X-ray"}, {"key": "Resolution", "value": "2.10 A"}, {"key": "Chains", "value": "A/B/C/D=1-512"}]}, {"database": "SMR", "id": "A0AAJ6N666", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "2.100.10.30", "properties": [{"key": "EntryName", "value": "Jacalin-like lectin domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.190.10", "properties": [{"key": "EntryName", "value": "Pesticidal crystal protein, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036404", "properties": [{"key": "EntryName", "value": "Jacalin-like_lectin_dom_sf"}]}, {"database": "InterPro", "id": "IPR036716", "properties": [{"key": "EntryName", "value": "Pest_crys_N_sf"}]}, {"database": "SUPFAM", "id": "SSF56849", "properties": [{"key": "EntryName", "value": "delta-Endotoxin (insectocide), N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAAEGVETVSELAPATDKVQNADMAEEDPIFTQLAQKMAAAAEKEEVPVDLLAQYMQVEAHDWHNRVRGAILGLISAVPKVGAAISRLIGLFWPANKVDIWEALRAEEYIRNIVQQELFEFEMRLLENDIQALETTVGRYDTAALTEKGNFLSIWISQADALYIRMRNSTNNIHLLLHMVTVSTLHLAALHERLTFGEELYGTNNSTNWTRDLVDKFETYTSDLIPNVFKRWKEWRPTQIEISAWVRRGSCGNLTCRPDVSYATVEDKISGALFSFQATNRNSTTLFLEVCEDHKTRMVNEAIADMASCLSPTFAFHKLLPDDIQTQFSPYDRQQFGQVFRGPYSQDLSHGLWTAFKNFRSRTTRSDQTLRDRILEVIIRAGHHVDAIQFVYDHSNPNLTTPGTVAGNAAGGTRHQVDVRDRPIQELRMEFSQDVLASLQLHFEDGTSTRKFGNELGWATRILTCTAPYGYRFSSWAFREDPGPYRTTAISVLRFQFTPELDMPLPASYMLS", "length": 512, "molWeight": 58161, "crc64": "25CEF8557CC820F9", "md5": "77148735572A1AA03C869B0384F5C3A5"}, "extraAttributes": {"countByFeatureType": {"Disulfide bond": 1}, "uniParcId": "UPI0024C5C0CD"}, "cluster_size": 1, "family": "Polypodiaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HF26", "uniProtkbId": "A0AA96HF26_9BILA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Laqueus californianus", "taxonId": 33478, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25255.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Brachiopoda", "Rhynchonelliformea", "Rhynchonellata", "Terebratellidina", "Laqueoidea", "Laqueidae", "Laqueus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25255.1"}], "value": "Hypoxia-inducible factor 1"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 10, "modifier": "EXACT"}, "end": {"value": 49, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 287, "modifier": "EXACT"}, "end": {"value": 317, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 317, "modifier": "EXACT"}, "end": {"value": 317, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25255.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25255.1"}], "value": "Laqu1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25255.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354990", "properties": [{"key": "ProteinId", "value": "WNN25255.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001610", "properties": [{"key": "EntryName", "value": "PAC"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013655", "properties": [{"key": "EntryName", "value": "PAS_fold_3"}]}, {"database": "NCBIfam", "id": "TIGR00229", "properties": [{"key": "EntryName", "value": "sensory_box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08447", "properties": [{"key": "EntryName", "value": "PAS_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00086", "properties": [{"key": "EntryName", "value": "PAC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNKNVLFCRITELTGYSPDELNGKSCYDYHHALDSAGLEKSYKTLFSKGQTMTSPYRFIAKHGGYVWVCTQATVISNTRTQKPQCVVCVNYVVSGMVSSGKIFSTVQCRSSTDSCLSKVESDIFPDCVQTTCAGFDEEDDLLHLAPTAGDACIPLDFPPCLSPDNSVLGDSCTLEDDQFDIVNPFETKNKRKFATDSVIIDPDWKIPSPASVNLNDKQRNNGTGIFVDSLLDEIDFENRAPYIPMDTNDFDLLDIFGPSVSPVSKETNSWSSAMSSTMSCVVPLHVEPDSTTTSNNTTPLHSPVNDVGAVDSKKEKS", "length": 317, "molWeight": 34712, "crc64": "3D492D4CD0DE3162", "md5": "289314DD53415E9C1EB94940C65C5B08"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Non-terminal residue": 1}, "uniParcId": "UPI002B2FD205"}, "cluster_size": 1, "family": "Laqueidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1C2", "uniProtkbId": "A0AAU7P1C2_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30737.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30737.1"}], "value": "Apolipoprotein E"}}], "flag": "Fragment"}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 9, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30737.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30737.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30737.1"}], "value": "1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30737.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892393", "properties": [{"key": "ProteinId", "value": "XBS30737.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "HARPEHRGAAGAPRLPPAQAACGSSAMPIPAEAPGSVPGRGPRGRRARPQRHPRAPGAPGGTGPRA", "length": 66, "molWeight": 6566, "crc64": "2B58D0813F952625", "md5": "34BDDCF8295A6F8E012D6C2D21FBA117"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 2, "Non-terminal residue": 2}, "uniParcId": "UPI0035D373E4"}, "cluster_size": 3, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA86J434", "uniProtkbId": "A0AA86J434_AURAU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Aurelia aurita", "commonName": "Moon jellyfish", "synonyms": ["Medusa aurita"], "taxonId": 6145, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53441.1"}], "lineage": ["Eukaryota", "Metazoa", "Cnidaria", "Scyphozoa", "Semaeostomeae", "Ulmaridae", "Aurelia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53441.1"}], "value": "Growth/differentiation factor protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53441.1"}], "value": "GDF"}}], "features": [{"type": "Domain", "location": {"start": {"value": 11, "modifier": "EXACT"}, "end": {"value": 237, "modifier": "EXACT"}}, "description": "TGF-beta propeptide", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00688"}]}, {"type": "Region", "location": {"start": {"value": 243, "modifier": "EXACT"}, "end": {"value": 270, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 243, "modifier": "EXACT"}, "end": {"value": 252, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 254, "modifier": "EXACT"}, "end": {"value": 270, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53441.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 270, "modifier": "EXACT"}, "end": {"value": 270, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53441.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B2HUVLRISDPSM", "citationType": "submission", "authors": ["Nakanishi T.", "Sarper S.E."], "title": "Tetraradial symmetry disturbance and recovery at feeding-dependent tentacle initiations in Aurelia aurita polyps.", "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53441.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC778156", "properties": [{"key": "ProteinId", "value": "BES53441.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR001111", "properties": [{"key": "EntryName", "value": "TGF-b_propeptide"}]}, {"database": "Pfam", "id": "PF00688", "properties": [{"key": "EntryName", "value": "TGFb_propeptide"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "SEINSQTYKSVTENITQALIEMTQESLLRSFGIDIKRKPSRSFTPHDYMLEVYSLLSGESDVARTTRINTVRGIIDTDSNNERLFRLPHQTFQFNVAGIPKTENLIGCEFRLQWRPAKVASRLRRYRSLRYKMFYKMILLGILPKDNVNGKNTTSSQRLEVTPLATRVFDLANMQAKWFSFEELAKFSQKARDRGVNIMKLVTYFVEMSSGRIVSPDDIGFNKHGRMDKEKGLLVLFSEDKMKKRDEEENSKGGRAKRGARRGRRKDRKG", "length": 270, "molWeight": 31273, "crc64": "3C1D5A7CCDAF17C6", "md5": "2DEF1F98D29E07DEBD26402CA0629E58"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 2, "Non-terminal residue": 2}, "uniParcId": "UPI002B300B61"}, "cluster_size": 1, "family": "Ulmaridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S1Q5", "uniProtkbId": "A0AA96S1Q5_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50061.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50061.1"}], "value": "Uncharacterized protein 11"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 353, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041696599"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50061.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460138", "properties": [{"key": "ProteinId", "value": "WNS50061.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.2000.10", "properties": [{"key": "EntryName", "value": "Frizzled cysteine-rich domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036790", "properties": [{"key": "EntryName", "value": "Frizzled_dom_sf"}]}], "sequence": {"value": "MTGKAVVCTVLLILAVATGTSVSSELQDEIHHRVLRQSLECSPSNETDSVCSSIINAGNISTSGNYSDNNKIISQRLGNVEKVFPNINSRCQQVYFAINCISLNAPCGTNVWCSTVNKTELQSLVQEKCTFTGEDEILYDVVKYLLLTRLEPSTLNRTDQADNAKCINIDIGDDIAVPKGIPLTIPPLPGIACEPYSGSVCSAVLGGQSVRTPNHTEPESSVQEILEGAKLVNEGNLTIECEKLLLDIQCSSTYLPCNGSVWCASNGAVELAALFNNSCACPEPVSSKCEAAKQNLIVTALLLRNVSLYQINQVPSTLQCQTLSLGSAAPTTSQTHFYTVFTAALMILVGMMV", "length": 353, "molWeight": 37817, "crc64": "82750C15986D5AFB", "md5": "D4DC9F1BC084B90ECE1C7F04A5E479D4"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B28B0F9"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU30", "uniProtkbId": "A0AAT9UU30_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41629.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41629.1"}], "value": "Cytochrome P450 6PZ22"}}], "flag": "Fragment"}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 377, "modifier": "EXACT"}, "end": {"value": 377, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41629.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41629.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117189", "properties": [{"key": "ProteinId", "value": "WIM41629.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002402", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-II"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00464", "properties": [{"key": "EntryName", "value": "EP450II"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYILTALFLSAVNVCLYVYWYLKKSRKFFDQYGIPSSPSHWLFGHMKDVILMRKPLWVGFQEMYRMLPELRFAGVYTLHRPFVMIRDPDLIKLILVKDFFHFNDHGFTINKEVEPMANTLFNMKGDEWKNLRIKLTGTFTSGKMKIMFPLMKNCAQDIKPLLTECFTKNQPFEAKDLFARFATDVIGSCAFGIDTHSLQNPESEFLIMSQKIFRNRWQATLRVLVPNLPASYIKTFGLQFFSPHLCEYFMKLVKEMVIYREQNNISRGDFLDLLIALKKEKNLVKTKQDQEDLDKFMSQIGEKSVKNDAEITIEVMAAQCFLFFLAGFEGASTTLTFLLFELAQKPEIQTKLRNEITTTLATNADGQFTYEMMNKMP", "length": 377, "molWeight": 43986, "crc64": "1FA655A5F7CF1565", "md5": "E3AF45A848F5D7E7FCC4B4279567DAFB"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D2702F"}, "cluster_size": 4, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN12", "uniProtkbId": "A0AA96MN12_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50063.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50063.1"}], "value": "Matrilin-2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 362, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041638055"}, {"type": "Domain", "location": {"start": {"value": 169, "modifier": "EXACT"}, "end": {"value": 346, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Region", "location": {"start": {"value": 121, "modifier": "EXACT"}, "end": {"value": 159, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 122, "modifier": "EXACT"}, "end": {"value": 134, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50063.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460140", "properties": [{"key": "ProteinId", "value": "WNS50063.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF84", "properties": [{"key": "EntryName", "value": "VWFA DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRALYLFATFFVVLTTAPMISQGQSQYPCDSYLRDYLPSLFTHCASCNYSAWSSWIATGQGKIVTACSTQYAEQFNRTRTGSSACTERVQYQTIHRCSASSILDRTAEQVATTMVNQLAIGAPPPTPPTLPTVPPTNSTTLGKRSSGLESRKMHPSLNRHRRQCDQTRYFVLVLDTSGSINSALFHKQTEYLATIVESLCGTIKVAMITYSTGVHPIMCFDFTEDKVQAAAKIRAATYISGGTDTAGALKYVKDTILQTSCGWTPSANDEKHLNIITLTDGAHNSDSLIPSLVNQLGQTTTNTELYAIAYGNVYQPGIAILVKNADTKHIFNIDAFDQQTETTSKVAKLANLCLGYHGVACR", "length": 362, "molWeight": 39546, "crc64": "7163D505E057AB23", "md5": "80E740D0950915524B8D9613E7AE4E57"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B2889DC"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UUA0", "uniProtkbId": "A0AAT9UUA0_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41688.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41688.1"}], "value": "Cytochrome P450 3638G6"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 39, "modifier": "EXACT"}, "end": {"value": 58, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 250, "modifier": "EXACT"}, "end": {"value": 267, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 482, "modifier": "EXACT"}, "end": {"value": 482, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41688.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117248", "properties": [{"key": "ProteinId", "value": "WIM41688.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVDFSLECCIPTTTKTHNIMTTTESHILVDFGTILENCVIAVALLLTGITLRYGFIYYKRMRRMMAMLNSFNQVPTKPIIGSIHLFTGNMRERFRKMVALSKQYEFPFVAWLMNVPIVFIGKCDDIQIVLNKSNDRDLQGVFEKIFCEGLIGLHGEQWRKSRRITISAFTPIMLSRYFSVFDEYAALLTKKLEKLCDTDEVFNIANYVFTIHLSSTVRNLAGYEIEPWSNESKQFVDAMTKCFQMEIKRFANPLLFFNVLYEIYLFITGNRKMYEIIHQLPRKIVQNRLAKYSMKGAPQYDGTSPSTNVSNSKLLIDSVLQRHATDVNFKEKNICDELLNLMIGGFESTGLVTSFMLLMLAMHQEAQEKVYHEIKTIYAHDGQEVQMEDLKKLVYMEQCINETLRKFPFIATDTRIHDEDIVLNNDRVIPAGCQIFLQFYDCHHDKEFFPNADNWDPEHFAPERKNIYKQAFFPFAGGLRSCVGSRYSMMSLKIQFVHLLRRYRFSTEMKMQDIHLISDLAVRNDTGYWLKIHSRQKN", "length": 538, "molWeight": 62804, "crc64": "AFDC81B5D228044D", "md5": "B031E24A114780F951A828C411AFBAC9"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 2, "Binding site": 1}, "uniParcId": "UPI0035D39388"}, "cluster_size": 3, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7J8S7", "uniProtkbId": "A0AAU7J8S7_LOCMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Locusta migratoria", "commonName": "Migratory locust", "taxonId": 7004, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89736.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Polyneoptera", "Orthoptera", "Caelifera", "Acrididea", "Acridomorpha", "Acridoidea", "Acrididae", "Oedipodinae", "Locusta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89736.1"}], "value": "Tudor domain-containing protein Tdr33"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 294, "modifier": "EXACT"}, "end": {"value": 385, "modifier": "EXACT"}}, "description": "ARID", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51011"}]}, {"type": "Region", "location": {"start": {"value": 124, "modifier": "EXACT"}, "end": {"value": 167, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 391, "modifier": "EXACT"}, "end": {"value": 760, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 838, "modifier": "EXACT"}, "end": {"value": 946, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 990, "modifier": "EXACT"}, "end": {"value": 1039, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1179, "modifier": "EXACT"}, "end": {"value": 1227, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1262, "modifier": "EXACT"}, "end": {"value": 1381, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1403, "modifier": "EXACT"}, "end": {"value": 1549, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1592, "modifier": "EXACT"}, "end": {"value": 1616, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 158, "modifier": "EXACT"}, "end": {"value": 167, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 396, "modifier": "EXACT"}, "end": {"value": 405, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 408, "modifier": "EXACT"}, "end": {"value": 487, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 500, "modifier": "EXACT"}, "end": {"value": 634, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 665, "modifier": "EXACT"}, "end": {"value": 703, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 710, "modifier": "EXACT"}, "end": {"value": 721, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 846, "modifier": "EXACT"}, "end": {"value": 856, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 876, "modifier": "EXACT"}, "end": {"value": 895, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 913, "modifier": "EXACT"}, "end": {"value": 927, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1267, "modifier": "EXACT"}, "end": {"value": 1278, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1289, "modifier": "EXACT"}, "end": {"value": 1318, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1356, "modifier": "EXACT"}, "end": {"value": 1375, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1423, "modifier": "EXACT"}, "end": {"value": 1439, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1471, "modifier": "EXACT"}, "end": {"value": 1508, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1511, "modifier": "EXACT"}, "end": {"value": 1532, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1593, "modifier": "EXACT"}, "end": {"value": 1603, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1764, "modifier": "EXACT"}, "end": {"value": 1764, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89736.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022853"}], "id": "KW-0156", "category": "Molecular function", "name": "Chromatin regulator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022499"}], "id": "KW-1017", "category": "PTM", "name": "Isopeptide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022553"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3S1R4NEJO2BB6", "citationType": "submission", "authors": ["Deng S.", "Wang J.", "Ma E.", "Zhang J.", "Xing S."], "title": "Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89736.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR912235", "properties": [{"key": "ProteinId", "value": "XBN89736.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005694", "properties": [{"key": "GoTerm", "value": "C:chromosome"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0000976", "properties": [{"key": "GoTerm", "value": "F:transcription cis-regulatory region binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006325", "properties": [{"key": "GoTerm", "value": "P:chromatin organization"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006357", "properties": [{"key": "GoTerm", "value": "P:regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd16100", "properties": [{"key": "EntryName", "value": "ARID"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd20389", "properties": [{"key": "EntryName", "value": "Tudor_ARID4_rpt1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd20390", "properties": [{"key": "EntryName", "value": "Tudor_ARID4_rpt2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.30.30.140:FF:000009", "properties": [{"key": "EntryName", "value": "AT-rich interactive domain-containing protein 4B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.30.30.140:FF:000097", "properties": [{"key": "EntryName", "value": "AT-rich interactive domain-containing protein 4B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "1.10.150.60", "properties": [{"key": "EntryName", "value": "ARID DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR051232", "properties": [{"key": "EntryName", "value": "ARID/SWI1_ChromRemod"}]}, {"database": "InterPro", "id": "IPR012603", "properties": [{"key": "EntryName", "value": "ARID4A/B_PWWP"}]}, {"database": "InterPro", "id": "IPR001606", "properties": [{"key": "EntryName", "value": "ARID_dom"}]}, {"database": "InterPro", "id": "IPR036431", "properties": [{"key": "EntryName", "value": "ARID_dom_sf"}]}, {"database": "InterPro", "id": "IPR016197", "properties": [{"key": "EntryName", "value": "Chromo-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR025995", "properties": [{"key": "EntryName", "value": "Tudor-knot"}]}, {"database": "PANTHER", "id": "PTHR13964:SF27", "properties": [{"key": "EntryName", "value": "HAT-TRICK, ISOFORM D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13964", "properties": [{"key": "EntryName", "value": "RBP-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01388", "properties": [{"key": "EntryName", "value": "ARID"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08169", "properties": [{"key": "EntryName", "value": "RBB1NT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF11717", "properties": [{"key": "EntryName", "value": "Tudor-knot"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01014", "properties": [{"key": "EntryName", "value": "ARID"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00501", "properties": [{"key": "EntryName", "value": "BRIGHT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF46774", "properties": [{"key": "EntryName", "value": "ARID-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54160", "properties": [{"key": "EntryName", "value": "Chromo domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51011", "properties": [{"key": "EntryName", "value": "ARID"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQGDDPPYLAVGTEVSAKYKGAFCEAKVRKVVRSVKCKVTFKQGLGTATVTDDHIRGTLRVGAVCEVKHPERKEQLEATITKIQDCSQYTVVFDDGDITTLRRSALCLKSGRHFAESETLDQLPLTHPEHFGNPVIGGRKGRRSRQAQDDSSDEDEESQRKGKKKEEKEADIGKVVCVELGDKKKQKDNWFPGLVVAPTAQDTVRIRVRDEYLVRSFKDGRYFTVPKKEATEFTREIGGKVDNNTLKTAVEKALQFLDKEELPPHWDRDLLFGLDESSANSDGIDSDGSDDEPREEKDHFVAQLYKFMDDRGTPINKGPIISGRDVDLYKLFKVVDKLGGYNRVTNHNQWKTITHKLGFGDISGNTNLVKVAYKRFLHSFEDFYRKLGCTMVNHPRGNRSRHRGGRSLIRDRDRATPVNTLKEKDKEKEKEKEKEKEKEKEKEKEKEKDKLKEKTKEKEKTKEKEKSKEKGKDKDKEKEKPSAEKSPEVTSKQPSVTAVGEKEQTKPPLVEEKKPSEQQSIRTKEIKKEKVKEKSDSTKEEKKTEKSKVKNEDKVKAEDKTKAEEKKQQAKQYEKDKQIKQEDKKLEEKIKTEEKVKIEEKDSPRALVRKEEHTKEKELRGRIDRGRSRFKEEPASGPEKQPENSQAVKQVDEKVKGNPSTEEEVVCKKTIKMEKIPDKKQDEEDKVRNKVKEDTLHQTKKESPISPQGRESRTPSREKAPPSHSPRAPVKKEDNSSTVLPAESPLSGPKKRGRKRKDTETNLEDALCHIGNNVTINVGDKLKVYYGPTQDSNKVTYEAKVLEIEDDDLFLVHYTGWNTRYDEWIKRSRIADNLSWSPSRAKRVKQQSQVQGARQTPSRRGRPSRDSVSSATAPQRPRSTTPSSVTSSSSRNKSPGSGGRSACAPSGNSSSRGRGRPPCRRRTRRSSAHTDISLASETESDGFDSEQEVELARLRSGNEKVTSSISNLENDELKQETLSFNEQYTDSKAEVSFSKDDDESIGGNCVIRSKGIADPSSSLEEEEADDSSIPATPEPENQIFCKRRTRRAFHCLDIKTETDSDENEPRGRDFDLNEIRSELKGIEKTVKVLPDVEECIIPLEIKTEVPQHIQEEDKSLASLKADNSSLRKLPDKICETVADDIYEFKEPEPFELEVRPKRESLLLDDRSCKGSRRSVIPRIFEDIGSSSPPKCDRSPQRKKSMYTKNGESSDSETKKKLCHSVQKSDDDSISALDNTLLSSSKTHGCEDAFDKLCVSPSFRLVNSRPASRGSVSGIGSISLFDGDDCGHDADDDDDDEDDDNDADDDMDDEDDNENDNDEQLGAIRSEPLFSYPQRNHEELLPPPSEDEFTFGEQIRPPSSNMGGRSSDSHQASANESPEEVMNMILKEAEYEDDTISAAIQRVIDQSIMDDDDQEIDLFGKGGPPTPPPPAPPPPAPPPLDMREARSRFTAAVDSSDTDSSDEESRLVIAPLDEEDEEEQEEEEEDNREEEDDDGDDEEEDEEDEEEENSSERGSPQPATEVGSSTDGSSELPSMTAGAGKSVPEAAVTLPDSMEVEMPLLSEDTPVIIETLPAQINAEENVQLATVGQPGEALTTSMTSTSNDSEGHSVSARENSIRESMPQLFSVYEKAVVNSASVRKDSGTCEMQDGGNRDEEMKMLERGEIVQQEIEVGEADLLDTAVMPESPKRRRLDTDIVEREECNEDPSFEDCSSKAVFAEQQELVKADDTKVLQDDIILLPQKEGELEVDELVQQQVQEEEEEEEE", "length": 1764, "molWeight": 198323, "crc64": "E205503EDAEC40EA", "md5": "DD29E9795904E40AE2BF1F3741862599"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 8, "Compositional bias": 16, "Non-terminal residue": 1}, "uniParcId": "UPI0035D30565"}, "cluster_size": 1, "family": "Acrididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7A0", "uniProtkbId": "A0AAN0N7A0_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34060.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34060.1"}], "value": "Glutamate receptor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 526, "modifier": "EXACT"}, "end": {"value": 545, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 604, "modifier": "EXACT"}, "end": {"value": 625, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 794, "modifier": "EXACT"}, "end": {"value": 815, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 393, "modifier": "EXACT"}, "end": {"value": 767, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00079"}]}, {"type": "Domain", "location": {"start": {"value": 403, "modifier": "EXACT"}, "end": {"value": 471, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor L-glutamate and glycine-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00918"}]}, {"type": "Binding site", "location": {"start": {"value": 480, "modifier": "EXACT"}, "end": {"value": 480, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 482, "modifier": "EXACT"}, "end": {"value": 482, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 487, "modifier": "EXACT"}, "end": {"value": 487, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 653, "modifier": "EXACT"}, "end": {"value": 653, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 654, "modifier": "EXACT"}, "end": {"value": 654, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 703, "modifier": "EXACT"}, "end": {"value": 703, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Site", "location": {"start": {"value": 632, "modifier": "EXACT"}, "end": {"value": 632, "modifier": "EXACT"}}, "description": "Crucial to convey clamshell closure to channel opening", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Site", "location": {"start": {"value": 659, "modifier": "EXACT"}, "end": {"value": 659, "modifier": "EXACT"}}, "description": "Interaction with the cone snail toxin Con-ikot-ikot", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 716, "modifier": "EXACT"}, "end": {"value": 771, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34060.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34060.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154986", "properties": [{"key": "ProteinId", "value": "WRW34060.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0022824", "properties": [{"key": "GoTerm", "value": "F:transmitter-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0007166", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000087", "properties": [{"key": "EntryName", "value": "glutamate receptor 4 isoform X2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000001", "properties": [{"key": "EntryName", "value": "Glutamate receptor ionotropic, kainate 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.287.70:FF:000010", "properties": [{"key": "EntryName", "value": "Putative glutamate receptor ionotropic kainate 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR001508", "properties": [{"key": "EntryName", "value": "Iono_Glu_rcpt_met"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00177", "properties": [{"key": "EntryName", "value": "NMDARECEPTOR"}]}, {"database": "SMART", "id": "SM00918", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLLGIIINEKVNSSTSLELIRLTINKLNDDLDLINSTKFKLESIVKLINGTNPIDAVDAINDLISEKILVFISTLNGPLHRIILSYSNNFKIPVIHSDQTQNSFYVSNLYQLSIKPIYLKALADLIQHFNWGNVIYLYNSDDGLAKLQYLFNVLLEKKYEWKIEKIKRFNNDKDAHQFIQKLEFQNPEIRKNILLDCDADVAKKIIIKHIHDIYLGRRNFNYLFTNLIFDDFWFKSTKEFGAINITGLRIFDPQSKSSRDIFTNLGLIENDKLSNLAKQFTLEDAFIHDGLKAIYYSLNDLSEKINETINSTNSKCFGCILHSFLKKVKFVGLTGNVEFSYNLFRQNFEIGAVQMTTSSQMTLYASWTKKNKLVVIPSKLYRKENEKKFERKHVIITSILEEPYLMWRKGDKDKKFYGNERFEGYCKDLADLLMKSMNFTYTLRLVNDSKYGAEDSRSVLGWNGMIGELIRKEADLAIAPLTITSARERVIDFTKPFMQMGISIMIKRPKEKYSDVFSFLSPLSKDIWICVFFSYVAVSITIFLSGKISQIEWSKGNIGVYQDRKFLDDFTLVNCFWFSLGAVMRQNTEISPRSFSARIAGSVWWFFTLIIISSYTANLAAFLTVERMITPINSADDLSKQTDVEYGILKDSSTQEFFKRTKISVYKRMWEYMSSRPHVLVNSYEDGINKVRKSRGKFAFLIESTKNDYVNERKPCDTIKVGRNLDAKGYGIATPLNSPLTIELNLKILSFKELSELTKLENKWWFDRSECKSIEKRSTNNIENSLTLNNVAGCFYILMFGIILSLIVCWIEYYYGNKKNSILNLKKENKIKTQIPDLFLANKTIKLRCPIHNR", "length": 854, "molWeight": 98984, "crc64": "02360D16E0718B14", "md5": "A16FA2C2290D252448ED109B07D5EDB4"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 3, "Domain": 2, "Binding site": 6, "Site": 2, "Disulfide bond": 1}, "uniParcId": "UPI00324C769A"}, "cluster_size": 2, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MNV3", "uniProtkbId": "A0AA96MNV3_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50080.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50080.1"}], "value": "Deleted in malignant brain tumors 1 protein-like protein 3"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 494, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041640971"}, {"type": "Domain", "location": {"start": {"value": 68, "modifier": "EXACT"}, "end": {"value": 169, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 174, "modifier": "EXACT"}, "end": {"value": 277, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 280, "modifier": "EXACT"}, "end": {"value": 386, "modifier": "EXACT"}}, "description": "Fibronectin type-III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50853"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 138, "modifier": "EXACT"}, "end": {"value": 148, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 245, "modifier": "EXACT"}, "end": {"value": 255, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50080.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460157", "properties": [{"key": "ProteinId", "value": "WNS50080.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "CDD", "id": "cd00063", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.10.250.10:FF:000016", "properties": [{"key": "EntryName", "value": "Scavenger receptor cysteine-rich protein type 12"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.10.250.10:FF:000007", "properties": [{"key": "EntryName", "value": "Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.10.250.10", "properties": [{"key": "EntryName", "value": "SRCR-like domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR003961", "properties": [{"key": "EntryName", "value": "FN3_dom"}]}, {"database": "InterPro", "id": "IPR036116", "properties": [{"key": "EntryName", "value": "FN3_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR001190", "properties": [{"key": "EntryName", "value": "SRCR"}]}, {"database": "InterPro", "id": "IPR036772", "properties": [{"key": "EntryName", "value": "SRCR-like_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR19331:SF465", "properties": [{"key": "EntryName", "value": "EGG PEPTIDE SPERACT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR19331", "properties": [{"key": "EntryName", "value": "SCAVENGER RECEPTOR DOMAIN-CONTAINING"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00041", "properties": [{"key": "EntryName", "value": "fn3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00530", "properties": [{"key": "EntryName", "value": "SRCR"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00258", "properties": [{"key": "EntryName", "value": "SPERACTRCPTR"}]}, {"database": "SMART", "id": "SM00060", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00202", "properties": [{"key": "EntryName", "value": "SR"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF49265", "properties": [{"key": "EntryName", "value": "Fibronectin type III"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56487", "properties": [{"key": "EntryName", "value": "SRCR-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50853", "properties": [{"key": "EntryName", "value": "FN3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00420", "properties": [{"key": "EntryName", "value": "SRCR_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50287", "properties": [{"key": "EntryName", "value": "SRCR_2"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MASWALSLALVLAVLFSLSVHLQAQQFDGYYSVQKSPSKSVPYTATQYKTLMYCCQDKPSVNTREGHIKLIDGPSLNEGRLMINYKNFYGAICADRFDTHDATTACHQLGFAGVETITGCCPYGTRPYGEIWIDELQCTSDQVWLPDCRRNAWGDEDCHNGQEIGIRCNPVLNLRLTGGRHSFEGRVEQYHAGRWGTVCDDTWDMKDARVACNQLGLGEPAKAITGTSRYFSLRKGSPILSRIDCVGTEIALGGCYHTGWRANTCPASSDNAGVVCKGPVPQDFKMDNVSESSASFSFTLPTQLQFTTAVKEYKVEFHPLPNVLGDKRVLFVTPSNSRSVKPRFTIQGLNPCSTYTFKVAVVASKLDGGTGPYSQPINVATQTQVPGDMRGLNGMPFNSSCASFKLEPPASTDDSCSADIQSYLIVFIPHPRFASPIPRTVSIPAPLPTGNKVTVCGLKYYVPYIFHASAVNRAGSGPQIRHDYYHYELSNRFN", "length": 494, "molWeight": 54322, "crc64": "A03AED8CEB5FB014", "md5": "0F6F33EC00CED9FC3F4F89B2A4384736"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 3, "Disulfide bond": 2}, "uniParcId": "UPI002B2DEAC7"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHM2", "uniProtkbId": "A0AAN0LHM2_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06409.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06409.1"}], "value": "Nicotinic acetylcholine receptor"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06409.1"}], "value": "nAChR"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003328"}], "value": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009237"}], "value": "Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 476, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "featureId": "PRO_5042664318"}, {"type": "Transmembrane", "location": {"start": {"value": 235, "modifier": "EXACT"}, "end": {"value": 259, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 266, "modifier": "EXACT"}, "end": {"value": 284, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 300, "modifier": "EXACT"}, "end": {"value": 321, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 429, "modifier": "EXACT"}, "end": {"value": 452, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Domain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 234, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel ligand-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02931"}]}, {"type": "Domain", "location": {"start": {"value": 241, "modifier": "EXACT"}, "end": {"value": 445, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel transmembrane", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02932"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06409.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06409.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP191248", "properties": [{"key": "ProteinId", "value": "WTM06409.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0022848", "properties": [{"key": "GoTerm", "value": "F:acetylcholine-gated monoatomic cation-selective channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004888", "properties": [{"key": "GoTerm", "value": "F:transmembrane signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "2.70.170.10:FF:000013", "properties": [{"key": "EntryName", "value": "Acetylcholine receptor subunit alpha"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.70.170.10", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel ligand-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.390", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR006202", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd"}]}, {"database": "InterPro", "id": "IPR036734", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd_sf"}]}, {"database": "InterPro", "id": "IPR006201", "properties": [{"key": "EntryName", "value": "Neur_channel"}]}, {"database": "InterPro", "id": "IPR036719", "properties": [{"key": "EntryName", "value": "Neuro-gated_channel_TM_sf"}]}, {"database": "InterPro", "id": "IPR038050", "properties": [{"key": "EntryName", "value": "Neuro_actylchol_rec"}]}, {"database": "InterPro", "id": "IPR006029", "properties": [{"key": "EntryName", "value": "Neurotrans-gated_channel_TM"}]}, {"database": "InterPro", "id": "IPR018000", "properties": [{"key": "EntryName", "value": "Neurotransmitter_ion_chnl_CS"}]}, {"database": "InterPro", "id": "IPR002394", "properties": [{"key": "EntryName", "value": "Nicotinic_acetylcholine_rcpt"}]}, {"database": "NCBIfam", "id": "TIGR00860", "properties": [{"key": "EntryName", "value": "LIC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR18945", "properties": [{"key": "EntryName", "value": "NEUROTRANSMITTER GATED ION CHANNEL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02931", "properties": [{"key": "EntryName", "value": "Neur_chan_LBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02932", "properties": [{"key": "EntryName", "value": "Neur_chan_memb"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00254", "properties": [{"key": "EntryName", "value": "NICOTINICR"}]}, {"database": "PRINTS", "id": "PR00252", "properties": [{"key": "EntryName", "value": "NRIONCHANNEL"}]}, {"database": "SUPFAM", "id": "SSF90112", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane pore"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63712", "properties": [{"key": "EntryName", "value": "Nicotinic receptor ligand binding domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00236", "properties": [{"key": "EntryName", "value": "NEUROTR_ION_CHANNEL"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNFILFLNIFVLFLIFKIKCNPDAKRLYEDLMAPYNKLVRPVFNSSEMINVKLGLKLFQILDLNLKKEYLLTNMMVSHEWNDYSLRWNFSDYGNVKQLYIPADKLWLPDIILYNNADDAYELSIKTNAVIHYDGTVIWQSPTTFKSHCEINVEYFPFDLQTCKLHFTSWTHGDNINLKHHNYKSSEPGIDLNNYFLNVEWDVLSVTALEQKKNFNCCTDIYSDIFFTIHLRRKTFFYIFSLLIPISLLSFLTVFVFYLPANSGEKVSLIISILLSLTFLLLIYIDIMPSTSICLPVLGKYLIFILLLVILSLIITCFILNVHFRSPNTHKMSPWSKTFFLKTLPPYLLIDLSIENQKFLLSSNNNITTNIKTFASKSIQTPTTGYIYSAEINRAIRNTLFIAYHLENKDTFENCKQDWQIMALVLDRMFFYLFFLLHLVGTIAIFLSITSIYDSSNPIDLQQSKINKDFENILKTF", "length": 476, "molWeight": 55678, "crc64": "309D2BB5E851EB32", "md5": "EBCEFCEBF4A55EA2AB31C4FD8EF2EBF6"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 4, "Domain": 2}, "uniParcId": "UPI00324CF442"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7YFX1", "uniProtkbId": "A0AAU7YFX1_NIDPL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Nidirana pleuraden", "commonName": "Yunnan pond frog", "synonyms": ["Babina pleuraden"], "taxonId": 369511, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87680.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Ranoidea", "Ranidae", "Nidirana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87680.1"}], "value": "Amplexin 6"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 127, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043919137"}, {"type": "Non-terminal residue", "location": {"start": {"value": 127, "modifier": "EXACT"}, "end": {"value": 127, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87680.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "38891597", "citationType": "journal article", "authors": ["Zheng P.", "Gong Y.", "Wang B.", "Yu H.", "Huang S.", "Liao X.", "Jiang J.", "Ran J.", "Xie F."], "citationCrossReferences": [{"database": "PubMed", "id": "38891597"}], "title": "Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.", "publicationDate": "2024", "journal": "Animals (Basel)", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87680.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-E24AGF4876IHP", "citationType": "submission", "authors": ["Zheng P."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87680.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP583596", "properties": [{"key": "ProteinId", "value": "XBY87680.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.10.60.10", "properties": [{"key": "EntryName", "value": "CD59"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR045860", "properties": [{"key": "EntryName", "value": "Snake_toxin-like_sf"}]}, {"database": "SUPFAM", "id": "SSF57302", "properties": [{"key": "EntryName", "value": "Snake toxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKVVITLLILGLLLIHGEALQCHKTIYLGENYFIYSVLNCTNNEDRCIIQLFTDVTYRYMYGCATQEDCLNENLVLKVEKCCDTDLCNDGVSEVSLMEAELQKKCDGWGRSSPCQCCVQSFIVLPDL", "length": 127, "molWeight": 14389, "crc64": "4AF2DB404CFFFB15", "md5": "0EC3F0215E00D8FE6362DDCF93D29050"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D28272"}, "cluster_size": 4, "family": "Ranidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBD5", "uniProtkbId": "A0AAU6PBD5_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20536.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20536.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 26, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 27, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043716805"}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20536.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20536.1"}], "value": "U_LCTX_20_Cm4", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20536.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480805", "properties": [{"key": "ProteinId", "value": "WXB20536.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.2080.10", "properties": [{"key": "EntryName", "value": "Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005055", "properties": [{"key": "EntryName", "value": "A10/PebIII"}]}, {"database": "InterPro", "id": "IPR036682", "properties": [{"key": "EntryName", "value": "OS_D_A10/PebIII_sf"}]}, {"database": "PANTHER", "id": "PTHR11257", "properties": [{"key": "EntryName", "value": "CHEMOSENSORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11257:SF12", "properties": [{"key": "EntryName", "value": "EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03392", "properties": [{"key": "EntryName", "value": "OS-D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF100910", "properties": [{"key": "EntryName", "value": "Chemosensory protein Csp2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "TIDTESHTKKMKTVIVLSLVVFSVAADTYTDRYDNTNIEEIMENCRMLVPYENCILEKQKCTKEGQELKSHLKEAIENGCAKCTETQKEKAKRAACILSNCQPAFWKKAMDMYDPNNNHRKEHQNEFDNATKCAVDCKKYKECDINTGRPVGE", "length": 153, "molWeight": 17563, "crc64": "8CF77EA48EEC39A8", "md5": "D55CA8ED889DCD9043301A81430D62AB"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D3852E"}, "cluster_size": 2, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96C6Z7", "uniProtkbId": "A0AA96C6Z7_9CUCU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Anthonomus eugenii", "commonName": "pepper weevil", "taxonId": 122869, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96194.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Coleoptera", "Polyphaga", "Cucujiformia", "Curculionidae", "Curculioninae", "Anthonomini", "Anthonomus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96194.1"}], "value": "Odorant binding protein C09"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96194.1"}], "value": "OBPC09"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96194.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DHPI8O2N9J4MB", "citationType": "submission", "authors": ["Segura Leon O.L.", "Lechuga-Paredes P.", "Cibrian Tovar J.", "Torres Huerta B."], "publicationDate": "JUL-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96194.1"}]}, {"referenceNumber": 2, "citation": {"id": "36834814", "citationType": "journal article", "authors": ["Lechuga-Paredes P.", "Segura-Leon O.L.", "Cibrian-Tovar J.", "Torres-Huerta B.", "Velazquez-Gonzalez J.C.", "Cruz-Jaramillo J.L."], "citationCrossReferences": [{"database": "PubMed", "id": "36834814"}], "title": "Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.", "publicationDate": "2023", "journal": "Int. J. Mol. Sci.", "firstPage": "0", "lastPage": "0", "volume": "24"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96194.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP056786", "properties": [{"key": "ProteinId", "value": "WNH96194.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "HANCMLVGLGYQDQNGHVNHDAIRRVVKIYYSDNDKVERIVQECSNVRGDKEETALKLFDVCFGKYLINIGHL", "length": 73, "molWeight": 8364, "crc64": "9F1D48A3966C7A97", "md5": "9181F64B0079FDF9480A933CF2E3F95A"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI002B2CD226"}, "cluster_size": 1, "family": "Curculionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N6A7", "uniProtkbId": "A0AAJ6N6A7_9ANNE", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Alvinella pompejana", "taxonId": 6376, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8GJA"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Sedentaria", "Canalipalpata", "Terebellida", "Terebelliformia", "Alvinellidae", "Alvinella"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8GJA"}], "value": "Xrcc3"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 76, "modifier": "EXACT"}, "end": {"value": 254, "modifier": "EXACT"}}, "description": "RecA family profile 1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50162"}]}, {"type": "Binding site", "location": {"start": {"value": 109, "modifier": "EXACT"}, "end": {"value": 109, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 110, "modifier": "EXACT"}, "end": {"value": 110, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 111, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 112, "modifier": "EXACT"}, "end": {"value": 112, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 113, "modifier": "EXACT"}, "end": {"value": 113, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 290, "modifier": "EXACT"}, "end": {"value": 290, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 300, "modifier": "EXACT"}, "end": {"value": 300, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 315, "modifier": "EXACT"}, "end": {"value": 315, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "1"}}, {"type": "Binding site", "location": {"start": {"value": 324, "modifier": "EXACT"}, "end": {"value": 324, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "2"}}, {"type": "Binding site", "location": {"start": {"value": 327, "modifier": "EXACT"}, "end": {"value": 327, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:456216"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "ligand": {"name": "ADP", "id": "ChEBI:CHEBI:456216", "label": "2"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022763"}], "id": "KW-0227", "category": "Biological process", "name": "DNA damage"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023204"}], "id": "KW-0234", "category": "Biological process", "name": "DNA repair"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}, {"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}], "references": [{"referenceNumber": 1, "citation": {"id": "37488098", "citationType": "journal article", "authors": ["Longo M.A.", "Roy S.", "Chen Y.", "Tomaszowski K.H.", "Arvai A.S.", "Pepper J.T.", "Boisvert R.A.", "Kunnimalaiyaan S.", "Keshvani C.", "Schild D.", "Bacolla A.", "Williams G.J.", "Tainer J.A.", "Schlacher K."], "citationCrossReferences": [{"database": "PubMed", "id": "37488098"}, {"database": "DOI", "id": "10.1038/s41467-023-40096-1"}], "title": "RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.", "publicationDate": "2023", "journal": "Nat. Commun.", "firstPage": "4445", "lastPage": "4445", "volume": "14"}, "referencePositions": ["X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ADP"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8GJA"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8GJA", "properties": [{"key": "Method", "value": "X-ray"}, {"key": "Resolution", "value": "2.60 A"}, {"key": "Chains", "value": "B/D/F=1-347"}]}, {"database": "SMR", "id": "A0AAJ6N6A7", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0033065", "properties": [{"key": "GoTerm", "value": "C:Rad51C-XRCC3 complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005657", "properties": [{"key": "GoTerm", "value": "C:replication fork"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0140664", "properties": [{"key": "GoTerm", "value": "F:ATP-dependent DNA damage sensor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000400", "properties": [{"key": "GoTerm", "value": "F:four-way junction DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045003", "properties": [{"key": "GoTerm", "value": "P:double-strand break repair via synthesis-dependent strand annealing"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071140", "properties": [{"key": "GoTerm", "value": "P:resolution of mitotic recombination intermediates"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0090656", "properties": [{"key": "GoTerm", "value": "P:t-circle formation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000722", "properties": [{"key": "GoTerm", "value": "P:telomere maintenance via recombination"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd19491", "properties": [{"key": "EntryName", "value": "XRCC3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR013632", "properties": [{"key": "EntryName", "value": "DNA_recomb/repair_Rad51_C"}]}, {"database": "InterPro", "id": "IPR016467", "properties": [{"key": "EntryName", "value": "DNA_recomb/repair_RecA-like"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR020588", "properties": [{"key": "EntryName", "value": "RecA_ATP-bd"}]}, {"database": "InterPro", "id": "IPR047348", "properties": [{"key": "EntryName", "value": "XRCC3-like_C"}]}, {"database": "PANTHER", "id": "PTHR46487", "properties": [{"key": "EntryName", "value": "DNA REPAIR PROTEIN XRCC3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46487:SF1", "properties": [{"key": "EntryName", "value": "DNA REPAIR PROTEIN XRCC3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08423", "properties": [{"key": "EntryName", "value": "Rad51"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF005856", "properties": [{"key": "EntryName", "value": "Rad51"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50162", "properties": [{"key": "EntryName", "value": "RECA_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDELDLNPRIIYSIKKAHLHDYGTILSLSAADIQRMTRLSASDVHQLQKTVAERIRRTPHTTAFHLHRRSGPAELNRDHLTTGCQQLDSFLRGGILTRTLTEIAGESASGKTQLCMQLCLTVQLPEQMGGLGGGAVYICTEDVFPNKRLVQMISQLKQRAHDVKVKDICFTDNIFIEHAAELDDLHYCVSKKVPVLLAQRHVKLIIIDSIAALFRCEHDSQSLQERARLMQLIASKLLQLANQFNVPAICVNQVSDVVEQHPSLLHQRKVIPTLGISWANHVTVRLMLMRTNYKLPVQQKNIEGDVIGSLDVQIRTMEVLFAPHLPNSLCRFIVDQDGVKGLPAKLN", "length": 347, "molWeight": 38973, "crc64": "E871BCC6684CE736", "md5": "E1ED1F4A3E34F90CB48C7ABAF75B9B28"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Binding site": 10}, "uniParcId": "UPI0027403183"}, "cluster_size": 1, "family": "Alvinellidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8KYD6", "uniProtkbId": "A0AAU8KYD6_HALDU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28589.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28589.1"}], "value": "Lamin A/C"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 370, "modifier": "EXACT"}}, "description": "IF rod", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51842"}]}, {"type": "Domain", "location": {"start": {"value": 395, "modifier": "EXACT"}, "end": {"value": 513, "modifier": "EXACT"}}, "description": "LTD", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51841"}]}, {"type": "Region", "location": {"start": {"value": 368, "modifier": "EXACT"}, "end": {"value": 400, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 206, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022754"}], "id": "KW-0403", "category": "Cellular component", "name": "Intermediate filament"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EGAS7BV8JDS8L", "citationType": "submission", "authors": ["Mikhailov K.", "Kravchuk O.", "Lyupina Y.", "Adameyko K."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28589.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP971923", "properties": [{"key": "ProteinId", "value": "XCN28589.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005882", "properties": [{"key": "GoTerm", "value": "C:intermediate filament"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "Gene3D", "id": "1.10.287.1490", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.5.170", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.1260", "properties": [{"key": "EntryName", "value": "Lamin Tail domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR039008", "properties": [{"key": "EntryName", "value": "IF_rod_dom"}]}, {"database": "InterPro", "id": "IPR001322", "properties": [{"key": "EntryName", "value": "Lamin_tail_dom"}]}, {"database": "InterPro", "id": "IPR036415", "properties": [{"key": "EntryName", "value": "Lamin_tail_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR45721", "properties": [{"key": "EntryName", "value": "LAMIN DM0-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45721:SF11", "properties": [{"key": "EntryName", "value": "LAMIN DM0-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00038", "properties": [{"key": "EntryName", "value": "Filament"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00932", "properties": [{"key": "EntryName", "value": "LTD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01391", "properties": [{"key": "EntryName", "value": "Filament"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF64593", "properties": [{"key": "EntryName", "value": "Intermediate filament protein, coiled coil region"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF74853", "properties": [{"key": "EntryName", "value": "Lamin A/C globular tail domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57997", "properties": [{"key": "EntryName", "value": "Tropomyosin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51842", "properties": [{"key": "EntryName", "value": "IF_ROD_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51841", "properties": [{"key": "EntryName", "value": "LTD"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNGDVGSSPRVNRQHERDEIKDLNDRFAGYIDTVKNLKGHNVSLEAEIEALKKEINTGADRLKEMYEAELEATRSLLEETEDEKARQAEHAQDVTKRNAELKKRLEELRNSVDGLERNLMSATQKLNTLDGQHNTTSHECMELGKTLRDVEREIEDLKRKIERLKRELETEVEEKKKLQDQIQQLKKELDDAKQEYLQDMEDLNATGQPSFQEGIDSPHFDTTLDDAIEEIRAISERECANHKMEMERRHRDNIDNLEDRTKRNADNIKKLTSDLRKLTDTNTTKIREIKKVQGLVDGLEKQVKDRDEEIARNRQDRNEEVSAHLDELRRLRENYEKQIQEYKELFDVKVDLDRELAAYKAMLAGEEDRLSIKPSPNKRRPPPPDSPAAAKRSKSDPKVSSTFAGYIQVVDVDPNGRYIQISNTSDKAENVGTFRIVHTVDDTGATNVFNFHSRSRLKAGITTTVWASSAGVEHNPPTDIVSKQVVVWGTGEKTTTRLRTSKGDAIATYVQRKEEQGQSSGSQDTQ", "length": 526, "molWeight": 60229, "crc64": "1B9076E6BE069D11", "md5": "6B261848185E23D1CFF869E31CCAE730"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 2, "Region": 1, "Coiled coil": 1}, "uniParcId": "UPI0035D2C9AC"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MLV6", "uniProtkbId": "A0AA96MLV6_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50097.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50097.1"}], "value": "Uncharacterized protein 25"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 42, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50097.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460174", "properties": [{"key": "ProteinId", "value": "WNS50097.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MYTGVPGQTISILVTMAYPVKRIAWPWAGLACLLVFIPCALLTSSSVQGEMITLTRLDVGGDIHNQKGWMRATITFNNKTSVIGSVCGQPDPASFYLACWTTGWLAVISQGTVGTVGFDVGEPDYPVISNLTCSGKSRLPCTFDMKGLGSCVQNRKNIAALSCCELNTTTTTTTT", "length": 175, "molWeight": 18668, "crc64": "295CCF187E50C002", "md5": "FBAE7428B329490C6C61E8ED7CE9D1B7"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI002B2F2F74"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P7D0", "uniProtkbId": "A0AAF0P7D0_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Tenuipotamon purpura", "taxonId": 2875585, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59327.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59327.1"}], "value": "Zinc finger protein 845"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59327.1"}], "value": "scaffold2031420"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006991"}], "value": "Belongs to the krueppel C2H2-type zinc-finger protein family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 49, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 77, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 78, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 120, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 148, "modifier": "EXACT"}, "end": {"value": 175, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 176, "modifier": "EXACT"}, "end": {"value": 203, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 204, "modifier": "EXACT"}, "end": {"value": 231, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 232, "modifier": "EXACT"}, "end": {"value": 254, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Region", "location": {"start": {"value": 266, "modifier": "EXACT"}, "end": {"value": 300, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 330, "modifier": "EXACT"}, "end": {"value": 356, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 266, "modifier": "EXACT"}, "end": {"value": 279, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 330, "modifier": "EXACT"}, "end": {"value": 344, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59327.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 390, "modifier": "EXACT"}, "end": {"value": 390, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59327.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00042"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59327.1"}], "value": "XDZL02", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59327.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59327.1"}], "value": "XDZL02", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59327.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515438", "properties": [{"key": "ProteinId", "value": "WMS59327.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005654", "properties": [{"key": "GoTerm", "value": "C:nucleoplasm"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0001227", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription repressor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042802", "properties": [{"key": "GoTerm", "value": "F:identical protein binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0001817", "properties": [{"key": "GoTerm", "value": "P:regulation of cytokine production"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0002682", "properties": [{"key": "GoTerm", "value": "P:regulation of immune system process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000322", "properties": [{"key": "EntryName", "value": "GDNF-inducible zinc finger protein 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000508", "properties": [{"key": "EntryName", "value": "Myeloid zinc finger 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000100", "properties": [{"key": "EntryName", "value": "Zinc finger 45-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000557", "properties": [{"key": "EntryName", "value": "zinc finger and SCAN domain-containing protein 29"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:002343", "properties": [{"key": "EntryName", "value": "Zinc finger protein 33A"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000016", "properties": [{"key": "EntryName", "value": "zinc finger protein 37 homolog"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000303", "properties": [{"key": "EntryName", "value": "Zinc finger protein 41"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.160.60", "properties": [{"key": "EntryName", "value": "Classic Zinc Finger"}, {"key": "MatchStatus", "value": "9"}]}, {"database": "InterPro", "id": "IPR036236", "properties": [{"key": "EntryName", "value": "Znf_C2H2_sf"}]}, {"database": "InterPro", "id": "IPR013087", "properties": [{"key": "EntryName", "value": "Znf_C2H2_type"}]}, {"database": "PANTHER", "id": "PTHR24399:SF54", "properties": [{"key": "EntryName", "value": "GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24399", "properties": [{"key": "EntryName", "value": "ZINC FINGER AND BTB DOMAIN-CONTAINING"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00096", "properties": [{"key": "EntryName", "value": "zf-C2H2"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "SMART", "id": "SM00355", "properties": [{"key": "EntryName", "value": "ZnF_C2H2"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "SUPFAM", "id": "SSF57667", "properties": [{"key": "EntryName", "value": "beta-beta-alpha zinc fingers"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "PROSITE", "id": "PS00028", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_1"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "PROSITE", "id": "PS50157", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_2"}, {"key": "MatchStatus", "value": "9"}]}], "sequence": {"value": "FAFTQKSAMKAHMRIHTGDKPFKCDECKATFRHSNSLTVHKRTHTGERPFVCDSCGAAFTQKSHLNLHKRSHAGIKPHMCDECNASFTKKDYLLAHKTKHAGGSTVKIEALVQAVGDSVYKCTDCEMVFTHPSSLTVHMRKHTGERPFVCAECGASFLYSSNLTTHRRKHTGERPYKCDQCEAAFILKSYLTMHLRKHSGERPFKCDECQACFTQKTHLSTHRRIHTGECPYKCEECGEAFRDGANFWRHKKKHLIGEGAATIRRRRNRRGRGRGRGRTVGRGSSRGRTTGGLRGSRNLPRRQAACVPHLSVDFDDIYEQFVLASEDDQLFIKEEPGDPSSNKDDEGEEEETPYIPIDPMVEIKLEGEDDEQQFDLEDRDMMIEEVNSEG", "length": 390, "molWeight": 44340, "crc64": "F3523D475DCE38A3", "md5": "CB75E0BEF86888D28D0B314225EE6B11"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 9, "Region": 2, "Compositional bias": 2, "Non-terminal residue": 2}, "uniParcId": "UPI002B305C81"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BIA8", "uniProtkbId": "A0AAQ5BIA8_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520344.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520344.1"}], "value": "YY1 associated protein 1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520344.1"}], "value": "YY1AP1"}}], "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 31, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BIA8"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BIA8"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520344.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520344.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520344.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520344.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL162734", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "BX088689", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BIA8", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000715143.1", "properties": [{"key": "ProteinId", "value": "ENSP00000520344.1"}, {"key": "GeneId", "value": "ENSG00000163374.21"}]}, {"database": "HGNC", "id": "HGNC:30935", "properties": [{"key": "GeneName", "value": "YY1AP1"}]}, {"database": "OpenTargets", "id": "ENSG00000163374", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000016256", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR052435", "properties": [{"key": "EntryName", "value": "YY1-Transcr_Regul"}]}, {"database": "PANTHER", "id": "PTHR16088:SF3", "properties": [{"key": "EntryName", "value": "GON-4-LIKE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR16088", "properties": [{"key": "EntryName", "value": "YY1 ASSOCIATED PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEDLFETFQDEMGFSNMEDDGPEEEERVAEPQANFNTPQALRFEELLANLLNEQHQIAKELFEQLKMKKPSAKQQKEVEKVKPQCKEVHQTLILDPAQRKRLQQQMQQHVQLLTQIHLLATCNPNLNPEASSTRICLFYKKTKQLPVLGKCCEEIQPHQWKPPIEREEHRLPFWLKVQPSSSKSVGGRRSLKVLREYQGLP", "length": 201, "molWeight": 23509, "crc64": "147C08A850E66FDA", "md5": "416AC84EA9C09B2267FCDB30C8BD9B27"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0032CB784D"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96SIC7", "uniProtkbId": "A0AA96SIC7_9STRA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Schizochytrium sp", "taxonId": 1907177, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94200.1"}], "lineage": ["Eukaryota", "Sar", "Stramenopiles", "Bigyra", "Labyrinthulomycetes", "Thraustochytrida", "Thraustochytriidae", "Schizochytrium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "value": "Elongation of fatty acids protein"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "value": "2.3.1.-"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94200.1"}], "value": "elo1"}}], "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:50252"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:16526"}, {"database": "ChEBI", "id": "CHEBI:57287"}, {"database": "ChEBI", "id": "CHEBI:57384"}, {"database": "ChEBI", "id": "CHEBI:58342"}, {"database": "ChEBI", "id": "CHEBI:90726"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:50253"}, "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "value": "Belongs to the ELO family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 44, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Transmembrane", "location": {"start": {"value": 56, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Transmembrane", "location": {"start": {"value": 102, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Transmembrane", "location": {"start": {"value": 153, "modifier": "EXACT"}, "end": {"value": 174, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Transmembrane", "location": {"start": {"value": 186, "modifier": "EXACT"}, "end": {"value": 205, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}, {"type": "Transmembrane", "location": {"start": {"value": 220, "modifier": "EXACT"}, "end": {"value": 240, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023160"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0275", "category": "Biological process", "name": "Fatty acid biosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022832"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0276", "category": "Biological process", "name": "Fatty acid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022516"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0444", "category": "Biological process", "name": "Lipid biosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023098"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0443", "category": "Biological process", "name": "Lipid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361115"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-81MDF9VBSAK2G", "citationType": "submission", "authors": ["Pan X.", "Yang Q."], "title": "Metabolism balance regulation for squalene production by disturbing triglycerides (TAG) synthesis in Schizochytrium sp.", "publicationDate": "SEP-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94200.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP562238", "properties": [{"key": "ProteinId", "value": "WNT94200.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0009922", "properties": [{"key": "GoTerm", "value": "F:fatty acid elongase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0034625", "properties": [{"key": "GoTerm", "value": "P:fatty acid elongation, monounsaturated fatty acid"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0034626", "properties": [{"key": "GoTerm", "value": "P:fatty acid elongation, polyunsaturated fatty acid"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0019367", "properties": [{"key": "GoTerm", "value": "P:fatty acid elongation, saturated fatty acid"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030148", "properties": [{"key": "GoTerm", "value": "P:sphingolipid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042761", "properties": [{"key": "GoTerm", "value": "P:very long-chain fatty acid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR002076", "properties": [{"key": "EntryName", "value": "ELO_fam"}]}, {"database": "PANTHER", "id": "PTHR11157:SF169", "properties": [{"key": "EntryName", "value": "ELONGATION OF FATTY ACIDS PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11157", "properties": [{"key": "EntryName", "value": "FATTY ACID ACYL TRANSFERASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01151", "properties": [{"key": "EntryName", "value": "ELO"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAAMLARMQSLDVNEIAKLYDDFYVLVPIYAVMVPILQKVYQGASSESSKGWKPIILAYNVIMSVFSACCAIGMAYILFVKFNGQIKGPDCSAFARDPLYDWIVYFFYMSKYVEFADTFFLIIKGKPVSWLHYFHHIGAAIDMGVLWKSGAEPTWIFVLFNGTVHTVMYAYYGAALMGKRLKGKNLITIMQIVQFLSGMGIFYTYPDIPCFASNSQLMFIYYYTNIYVGIVLLFFLNFYVQSYLRPQRKAPGKSE", "length": 255, "molWeight": 29194, "crc64": "8EAA3F5E064AFDDA", "md5": "FE4E28514D690B938A3BA177BC087815"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6}, "uniParcId": "UPI0016E80AC6"}, "cluster_size": 1, "family": "Thraustochytriidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMN1", "uniProtkbId": "A0AAU0QMN1_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56489.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 48, "modifier": "EXACT"}, "end": {"value": 68, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 137, "modifier": "EXACT"}, "end": {"value": 160, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 180, "modifier": "EXACT"}, "end": {"value": 197, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 274, "modifier": "EXACT"}, "end": {"value": 294, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 301, "modifier": "EXACT"}, "end": {"value": 321, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56489.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56489.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970382", "properties": [{"key": "ProteinId", "value": "WPO56489.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSTSDQIELTTKTEIFFSKLCHIAYLHGFPNLWITDLNFSKTFKKYHFIIYKTLDVIFYLFIISQWTASLKQHNLTQKQMSDNLLFSYAQPSLYSYRLALDYHQDKIREIIFNVFVKLKGLHNDEKLEKKMIRKTTILSLVFLTMVCSCLVFFGCQGIYADDAKFVTVITIWPDVEDTRLVAYLGRVVIYIIWWLLIMNVMASYNAVLTLMVTLEYQFKYLGKYFRELDLIFEEDISQKEKERKYYEGVKLGISLHSIILRCVELTQDSCTNVYGLHILVNISVLVSVMFQMVYTGRDLDSVFSTLATGTAMLISTGYFMWCAGDVTVEASFLATDMYFSGWHNCGENAPRVRRLLILAMMQAQNPVEITIMGVFTVSYQAFLSIVKSSYTIFTVLY", "length": 397, "molWeight": 46073, "crc64": "3A579F765F5AA8BA", "md5": "2EE76F8CF0602EC1819FCC303C4B941B"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 5}, "uniParcId": "UPI0030915CB4"}, "cluster_size": 2, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEU6", "uniProtkbId": "A0AB38ZEU6_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02760.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02760.1"}], "value": "Venom S1 protease 34"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 399, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044228779"}, {"type": "Domain", "location": {"start": {"value": 161, "modifier": "EXACT"}, "end": {"value": 396, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 399, "modifier": "EXACT"}, "end": {"value": 399, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02760.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022825"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02760.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517510", "properties": [{"key": "ProteinId", "value": "WXI02760.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00190", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.40.10.10:FF:000015", "properties": [{"key": "EntryName", "value": "Atrial natriuretic peptide-converting enzyme"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001314", "properties": [{"key": "EntryName", "value": "Peptidase_S1A"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR018114", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24252", "properties": [{"key": "EntryName", "value": "ACROSIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24252:SF7", "properties": [{"key": "EntryName", "value": "HYALIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00722", "properties": [{"key": "EntryName", "value": "CHYMOTRYPSIN"}]}, {"database": "SMART", "id": "SM00020", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00134", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKLLILIFCIWATKISGYKHFESYKLKPGDTKNIWPVTNECHSESRWNFEACEGCKIVLSCALFRLNCADHMVTVYNGKHTSRHCGPNDSYLIKTSHKNWMNVVIENRGLKPGSYCHVTATKPYFNAKYETIDSSEHGVAVEARGPSVCDCGWSNKSPARIIGGHEASPNEYPFAAILMIKKTSSFLCGGSIISPYHVLSAAHCTNPFRGIQLSVIVGEHDLRTSKDTPFTKIIDVEKVYDHPNYNNQTNSFDISVLKLRNRIKFNEAIGPVCLPTGIKSDLLNQYLKVLGWGQIMYNGPKSPTLRKVNLKVIDLDICKTIYGHLDAKHKSQICTWGPNKDSCQGDSGGPLVWLDPNTNRFVQVGLVSFARECGYTDPGVNTDISFFIDWINNVVAESG", "length": 399, "molWeight": 44545, "crc64": "9B3399798AE077DF", "md5": "D235EC8EEA45472A14B228609FE066F8"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388C0A5D"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N5X7", "uniProtkbId": "A0AAN0N5X7_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34076.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34076.1"}], "value": "G-protein coupled receptor 3"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004487"}], "value": "Cell projection, neuron projection", "id": "SL-0518"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007242"}], "value": "Belongs to the G-protein coupled receptor 3 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 38, "modifier": "EXACT"}, "end": {"value": 57, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 632, "modifier": "EXACT"}, "end": {"value": 653, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 665, "modifier": "EXACT"}, "end": {"value": 683, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 741, "modifier": "EXACT"}, "end": {"value": 761, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 820, "modifier": "EXACT"}, "end": {"value": 841, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 847, "modifier": "EXACT"}, "end": {"value": 866, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 632, "modifier": "EXACT"}, "end": {"value": 874, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 3 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50259"}]}, {"type": "Coiled coil", "location": {"start": {"value": 899, "modifier": "EXACT"}, "end": {"value": 933, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023273"}], "id": "KW-0966", "category": "Cellular component", "name": "Cell projection"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34076.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34076.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155002", "properties": [{"key": "ProteinId", "value": "WRW34076.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043005", "properties": [{"key": "GoTerm", "value": "C:neuron projection"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd15293", "properties": [{"key": "EntryName", "value": "7tmC_GPR158-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR017978", "properties": [{"key": "EntryName", "value": "GPCR_3_C"}]}, {"database": "InterPro", "id": "IPR043458", "properties": [{"key": "EntryName", "value": "GPR158/179"}]}, {"database": "InterPro", "id": "IPR054714", "properties": [{"key": "EntryName", "value": "GPR158_179_extracellular"}]}, {"database": "PANTHER", "id": "PTHR32546", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR 158-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR32546:SF16", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR CG31760-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00003", "properties": [{"key": "EntryName", "value": "7tm_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF22572", "properties": [{"key": "EntryName", "value": "GPR158_179_EC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50259", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F3_4"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MENLNGFFGNSLNNFSKNYSQINQIIFYRLRVKLHRIYLIYFLFFFLNLIVCEDSILPTSSLKSTSIFLFKEDDEYQAVITSPSFEKKNSKTQSSSIPLFSFTSLSKDTSNLIDSSNFEFYNSENIAPNIFKQEKDFSSNEQIRNKYSLVSNLEEEEKQSYINDFNIDNLTNYKLNENELVSNLNKSSKILNYRKFQNKNNVNLVEDLPYLNKENEKVLKKLDEISKGEDCNFDHPLIIKWADKINQDNSKQKMLNNILNPKFVEFPKLIKDREINLKLNKFYKDVIEKLKLISYLFYDNSDQIDTDQHLKLTKKIMREMKNLNSDILRARLILLDTASKKMKKRSNFNKENLGSNYKMLLNKNFERLKKSDEGLIETLNAEIKAQSILTFVKEHKEPIQSFKNLKFQINYKTAKWLHIENVENSSAPLENIKKLLEEEHIQVYSKNERIFAGWTNMYFDCILNKWLSSFTILLVSCNNCKINKLNNSFNETFDMSLLGILSVDFSLNNLDINQCSDSSLKEDYSLFDTLNVLNKKKELVKLDSQKSHINNTRLLINFDNTNKCHHTSSQCEFRPGYGLRKGGYMCKCLPGYYAFLPEFTGTEVENLWYEKNHINKKLAYLSPCLSFYNWKFRISLLTISILCICIIFVLTYYIHHYRKKKVFKVASPVFLSLTLLGCCIMYSEMIMAFPVLNTGFCIMVKLTRHMGFCITYSALLLKTWRVSLTYRVKSAHKLKLTDRQLLQWLFPILLVMAIFLGTWMVSSPPQTIMIVDSNFRKFKDCEYNNWDHCCEIGKFLFLLWGIKICYSVRNAESFFNEAKYITWAIYNITIVNLIMITIQNAGPDVKYFLTFLRSQLSTATTILLIFGPKFYILIKGEGDSWNVKVKARGINASFSLTGLGVVHEELTDLYQENEELKEQVHKLATKVEMMRLMQMQVNNRHFKFKNNSSTAAGSGSVTHSSAANSSVVVNSTATAASVTGLTAPNTSTANAYHSYSYNQLSSPAIDSAGIGLVTSLVGSVVGVTPGLPFTLGSPATSSCQRISPAAELQSEKV", "length": 1053, "molWeight": 121264, "crc64": "C851379B1B432B53", "md5": "A3B943761A6B8860653A157952E78C24"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6, "Domain": 1, "Coiled coil": 1}, "uniParcId": "UPI003249DC16"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MMD7", "uniProtkbId": "A0AA96MMD7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50081.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50081.1"}], "value": "Uncharacterized protein 18"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 280, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041646365"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50081.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460158", "properties": [{"key": "ProteinId", "value": "WNS50081.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MQVWGWISPLVYIIVLAGISDKGLVHCQSKRKLAVERKPVVPNTDTKVGHSILYNRLLTPTDLKEFASARVHSADFTTRLEITKSGTQGLQRVLRIPILPPSQLTPSQPYYVQVSAGLDQSRTSQAFSTMFSLSDGSHVTGFVLPGTEDRSARVLCYGMEADEDSPAGLDRPLSRYRLINRTPSDDDDDDDASSNRVVIVSNLGARRIAPVNETTILFKPGRDWGSCSAVEYSTFRNVVGFSRHLNPRKGLFFDVHLSRSNGRLNLLYLLIKLVRESSLI", "length": 280, "molWeight": 31131, "crc64": "A8B6BF271C072324", "md5": "5519106E6CFF5EFB7380E0D08C2F6E49"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B2CCB97"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BH43", "uniProtkbId": "A0AAQ5BH43_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519209.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519209.1"}], "value": "Desmoplakin"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519209.1"}], "value": "DSP"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009109"}], "value": "Belongs to the plakin or cytolinker family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Coiled coil", "location": {"start": {"value": 411, "modifier": "EXACT"}, "end": {"value": 441, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BH43"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BH43"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519209.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "14574404", "citationType": "journal article", "authors": ["Mungall A.J.", "Palmer S.A.", "Sims S.K.", "Edwards C.A.", "Ashurst J.L.", "Wilming L.", "Jones M.C.", "Horton R.", "Hunt S.E.", "Scott C.E.", "Gilbert J.G.", "Clamp M.E.", "Bethel G.", "Milne S.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Andrews T.D.", "Ashwell R.I.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beare D.M.", "Beasley H.", "Beasley O.", "Bird C.P.", "Blakey S.", "Bray-Allen S.", "Brook J.", "Brown A.J.", "Brown J.Y.", "Burford D.C.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Clark S.Y.", "Clark G.", "Clee C.M.", "Clegg S.", "Cobley V.", "Collier R.E.", "Collins J.E.", "Colman L.K.", "Corby N.R.", "Coville G.J.", "Culley K.M.", "Dhami P.", "Davies J.", "Dunn M.", "Earthrowl M.E.", "Ellington A.E.", "Evans K.A.", "Faulkner L.", "Francis M.D.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Ghori M.J.", "Gilby L.M.", "Gillson C.J.", "Glithero R.J.", "Grafham D.V.", "Grant M.", "Gribble S.", "Griffiths C.", "Griffiths M.", "Hall R.", "Halls K.S.", "Hammond S.", "Harley J.L.", "Hart E.A.", "Heath P.D.", "Heathcott R.", "Holmes S.J.", "Howden P.J.", "Howe K.L.", "Howell G.R.", "Huckle E.", "Humphray S.J.", "Humphries M.D.", "Hunt A.R.", "Johnson C.M.", "Joy A.A.", "Kay M.", "Keenan S.J.", "Kimberley A.M.", "King A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.R.", "Lloyd D.M.", "Loveland J.E.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Maslen G.L.", "Matthews L.", "McCann O.T.", "McLaren S.J.", "McLay K.", "McMurray A.", "Moore M.J.", "Mullikin J.C.", "Niblett D.", "Nickerson T.", "Novik K.L.", "Oliver K.", "Overton-Larty E.K.", "Parker A.", "Patel R.", "Pearce A.V.", "Peck A.I.", "Phillimore B.", "Phillips S.", "Plumb R.W.", "Porter K.M.", "Ramsey Y.", "Ranby S.A.", "Rice C.M.", "Ross M.T.", "Searle S.M.", "Sehra H.K.", "Sheridan E.", "Skuce C.D.", "Smith S.", "Smith M.", "Spraggon L.", "Squares S.L.", "Steward C.A.", "Sycamore N.", "Tamlyn-Hall G.", "Tester J.", "Theaker A.J.", "Thomas D.W.", "Thorpe A.", "Tracey A.", "Tromans A.", "Tubby B.", "Wall M.", "Wallis J.M.", "West A.P.", "White S.S.", "Whitehead S.L.", "Whittaker H.", "Wild A.", "Willey D.J.", "Wilmer T.E.", "Wood J.M.", "Wray P.W.", "Wyatt J.C.", "Young L.", "Younger R.M.", "Bentley D.R.", "Coulson A.", "Durbin R.", "Hubbard T.", "Sulston J.E.", "Dunham I.", "Rogers J.", "Beck S."], "citationCrossReferences": [{"database": "PubMed", "id": "14574404"}, {"database": "DOI", "id": "10.1038/nature02055"}], "title": "The DNA sequence and analysis of human chromosome 6.", "publicationDate": "2003", "journal": "Nature", "firstPage": "805", "lastPage": "811", "volume": "425"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519209.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519209.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519209.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL031058", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "KF458095", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "RefSeq", "id": "NP_001393520.1", "properties": [{"key": "NucleotideSequenceId", "value": "NM_001406591.1"}]}, {"database": "SMR", "id": "A0AAQ5BH43", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000713910.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519209.1"}, {"key": "GeneId", "value": "ENSG00000096696.17"}]}, {"database": "GeneID", "id": "1832", "properties": [{"key": "Description", "value": "-"}]}, {"database": "CTD", "id": "1832", "properties": [{"key": "Description", "value": "-"}]}, {"database": "HGNC", "id": "HGNC:3052", "properties": [{"key": "GeneName", "value": "DSP"}]}, {"database": "OpenTargets", "id": "ENSG00000096696", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000154843", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 6"}]}, {"database": "GO", "id": "GO:0045104", "properties": [{"key": "GoTerm", "value": "P:intermediate filament cytoskeleton organization"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00176", "properties": [{"key": "EntryName", "value": "SPEC"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "1.20.58.60:FF:000123", "properties": [{"key": "EntryName", "value": "Desmoplakin a"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.1060", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.60", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.30.30.40", "properties": [{"key": "EntryName", "value": "SH3 Domains"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR043197", "properties": [{"key": "EntryName", "value": "Plakin"}]}, {"database": "InterPro", "id": "IPR018159", "properties": [{"key": "EntryName", "value": "Spectrin/alpha-actinin"}]}, {"database": "PANTHER", "id": "PTHR23169:SF26", "properties": [{"key": "EntryName", "value": "DESMOPLAKIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23169", "properties": [{"key": "EntryName", "value": "ENVOPLAKIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF21019", "properties": [{"key": "EntryName", "value": "Spectrin_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF46966", "properties": [{"key": "EntryName", "value": "Spectrin repeat"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQVCTHLE", "length": 479, "molWeight": 55847, "crc64": "B08F4CE1BA6FB47D", "md5": "4AE82FFFCD0BCED0AA27B9B297FF7E55"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Coiled coil": 1}, "uniParcId": "UPI002016F9D6"}, "cluster_size": 3, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJA5", "uniProtkbId": "A0AAU7LJA5_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28213.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28213.1"}], "value": "MADS18"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28213.1"}], "value": "MADS18"}}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28213.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28213.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400853", "properties": [{"key": "ProteinId", "value": "XBP28213.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MNGGIFQLKQLAHKNYNKCILHFKNPPNNDSTNAIVEAHKKFMLNETKQHNEILEEVELEKERDKMREGENEWWDVPIETLDLEELQQMHSSFQVIRNNSTNNFNERSVFVEAHKKFMLDEAKQQHNEILKEVELEKERDEMVEIIKN", "length": 148, "molWeight": 17719, "crc64": "267FD94AED82EF2A", "md5": "83AF1A82CF4B011AA05EDBC871AC34ED"}, "extraAttributes": {"uniParcId": "UPI0035D35388"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NPD7", "uniProtkbId": "A0AA96NPD7_GYMSY", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Gymnema sylvestre", "commonName": "Gurmar", "synonyms": ["Periploca sylvestris"], "taxonId": 4068, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99861.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "asterids", "lamiids", "Gentianales", "Apocynaceae", "Asclepiadoideae", "Marsdenieae", "Gymnema"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99861.1"}], "value": "RPM1-interacting protein 4"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99861.1"}], "value": "RIN4"}}], "features": [{"type": "Domain", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "RIN4 pathogenic type III effector avirulence factor Avr cleavage site", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF05627"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 102, "modifier": "EXACT"}, "end": {"value": 127, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 46, "modifier": "EXACT"}, "end": {"value": 56, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99861.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8JD0E4S7VLN46", "citationType": "submission", "authors": ["Kalariya K.A."], "title": "Transcriptomic revealing of plant pathogen interaction in Gymnema sylvestre.", "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT99861.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR484763", "properties": [{"key": "ProteinId", "value": "WNT99861.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR040387", "properties": [{"key": "EntryName", "value": "RIN4/NOI4"}]}, {"database": "InterPro", "id": "IPR008700", "properties": [{"key": "EntryName", "value": "TypeIII_avirulence_cleave"}]}, {"database": "PANTHER", "id": "PTHR33159:SF6", "properties": [{"key": "EntryName", "value": "RPM1-INTERACTING PROTEIN 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR33159", "properties": [{"key": "EntryName", "value": "RPM1-INTERACTING PROTEIN 4 (RIN4) FAMILY PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF05627", "properties": [{"key": "EntryName", "value": "AvrRpt-cleavage"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "GSNSGRPSRPSAGSEHSFEKSPLHPHYQAKVKGPGGGSPAREGKNSYDSSHGTPTRSRMKPVTRTDGSPDRGAAVPRFGEWDENNPQSADNFTHIFNQVREERHTGSSNAPGAKFESPYHNARQRSENGNKVCCFPFLRK", "length": 140, "molWeight": 15333, "crc64": "4E0C33A2F4D9AC14", "md5": "61B4DD89E0F47AA8D21F1647BC5D0B52"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 2, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI002B2D539F"}, "cluster_size": 1, "family": "Apocynaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0SZ55", "uniProtkbId": "A0AAF0SZ55_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenuipotamon panxiense", "taxonId": 2841827, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59216.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59216.1"}], "value": "Haloalkane dehalogenase-like protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59216.1"}], "value": "scaffold1214736"}}], "features": [{"type": "Domain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 198, "modifier": "EXACT"}}, "description": "AB hydrolase-1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00561"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59216.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 204, "modifier": "EXACT"}, "end": {"value": 204, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59216.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59216.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59216.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59216.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59216.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515339", "properties": [{"key": "ProteinId", "value": "WMS59216.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "3.40.50.1820", "properties": [{"key": "EntryName", "value": "alpha/beta hydrolase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000073", "properties": [{"key": "EntryName", "value": "AB_hydrolase_1"}]}, {"database": "InterPro", "id": "IPR029058", "properties": [{"key": "EntryName", "value": "AB_hydrolase_fold"}]}, {"database": "InterPro", "id": "IPR050228", "properties": [{"key": "EntryName", "value": "Carboxylesterase_BioH"}]}, {"database": "PANTHER", "id": "PTHR43194", "properties": [{"key": "EntryName", "value": "HYDROLASE ALPHA/BETA FOLD FAMILY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43194:SF2", "properties": [{"key": "EntryName", "value": "PEROXISOMAL MEMBRANE PROTEIN LPX1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00561", "properties": [{"key": "EntryName", "value": "Abhydrolase_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53474", "properties": [{"key": "EntryName", "value": "alpha/beta-Hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "TFTESYSHELHCMTLRLLLDHLKLRGITLVCQDWGGLTGLPVVRDCPHLFSRLVIMNTGLPTGNRAFSFNKAMPFLMWRSYAQLYGTALPVGRIFTKALLNAHPAVVKGYEAPFPSALYRAGAAQWPLLVPLTANTPVAADMQATRDFLAQEWQKPALVMFSDRDPITRGMERMFLKLMPHAIVKTVAGAKHFLQEDKGEELTT", "length": 204, "molWeight": 22842, "crc64": "58DFC5FF3352AF6E", "md5": "BD4B2FF446B68D802459F5D5B42E4471"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2EB13C"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PB51", "uniProtkbId": "A0AAU6PB51_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20550.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20550.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20550.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20550.1"}], "value": "U_LCTX_11_Cm18", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20550.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480819", "properties": [{"key": "ProteinId", "value": "WXB20550.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "KNSINEIEFTKLWWELFSSSDSHALGNFLAGTTRFST", "length": 37, "molWeight": 4236, "crc64": "4F232948D5D18587", "md5": "7F2081423DE9B8E497B22EC4CECDEA93"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D38A8B"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJ80", "uniProtkbId": "A0AAU7LJ80_PYRAP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pyrrhocoris apterus", "commonName": "Sap sucking bug", "synonyms": ["Cimex apterus"], "taxonId": 37000, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28115.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Pentatomomorpha", "Pyrrhocoroidea", "Pyrrhocoridae", "Pyrrhocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28115.1"}], "value": "Prothoracicotropic hormone"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28115.1"}], "value": "PTTH"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043986236"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-6ACPF5V3ANG4V", "citationType": "submission", "authors": ["Zhang J.-L.", "Xu H.-J."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28115.1"}], "value": "JZ-2024a", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28115.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP882644", "properties": [{"key": "ProteinId", "value": "XBP28115.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.10.90.10", "properties": [{"key": "EntryName", "value": "Cystine-knot cytokines"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR029034", "properties": [{"key": "EntryName", "value": "Cystine-knot_cytokine"}]}, {"database": "InterPro", "id": "IPR052876", "properties": [{"key": "EntryName", "value": "Insect_Hormone_Regulators"}]}, {"database": "PANTHER", "id": "PTHR39940", "properties": [{"key": "EntryName", "value": "PROTHORACICOTROPIC HORMONE, ISOFORM F"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR39940:SF1", "properties": [{"key": "EntryName", "value": "PROTHORACICOTROPIC HORMONE, ISOFORM F"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57501", "properties": [{"key": "EntryName", "value": "Cystine-knot cytokines"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYRIFARIVLLTALFSYFDVALGNMCINTSVECAGRPQLLDLGRGHYPRYITTVDCGSHSCLYPCTSRTYRVKVLKEKSYEDTKFDGSLPPSLRDEWKFVPIDVSVSCVCGVYDEKKGSII", "length": 121, "molWeight": 13690, "crc64": "64CEFD0B728EC51F", "md5": "C6FF541B02EF1A3DC0BE0FCEAD672795"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D39423"}, "cluster_size": 1, "family": "Pyrrhocoridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96C6E7", "uniProtkbId": "A0AA96C6E7_9CUCU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Anthonomus eugenii", "commonName": "pepper weevil", "taxonId": 122869, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96191.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Coleoptera", "Polyphaga", "Cucujiformia", "Curculionidae", "Curculioninae", "Anthonomini", "Anthonomus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96191.1"}], "value": "Odorant binding protein C04a"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96191.1"}], "value": "OBPC04a"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96191.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 74, "modifier": "EXACT"}, "end": {"value": 74, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96191.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DHPI8O2N9J4MB", "citationType": "submission", "authors": ["Segura Leon O.L.", "Lechuga-Paredes P.", "Cibrian Tovar J.", "Torres Huerta B."], "publicationDate": "JUL-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96191.1"}]}, {"referenceNumber": 2, "citation": {"id": "36834814", "citationType": "journal article", "authors": ["Lechuga-Paredes P.", "Segura-Leon O.L.", "Cibrian-Tovar J.", "Torres-Huerta B.", "Velazquez-Gonzalez J.C.", "Cruz-Jaramillo J.L."], "citationCrossReferences": [{"database": "PubMed", "id": "36834814"}], "title": "Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.", "publicationDate": "2023", "journal": "Int. J. Mol. Sci.", "firstPage": "0", "lastPage": "0", "volume": "24"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96191.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP056780", "properties": [{"key": "ProteinId", "value": "WNH96191.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "EVMTGNFPNDPALKKHLVCFEKMAGFLDESGHHVKDVLIKEMAMKLGDEAKATQLYDKCFVDTGNVEEDVFKSA", "length": 74, "molWeight": 8262, "crc64": "38F99DD4D8848C9D", "md5": "902798F85B7A823F4B2D77D193D0C582"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI002B2BE9EB"}, "cluster_size": 1, "family": "Curculionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LJ07", "uniProtkbId": "A0AAN0LJ07_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34058.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34058.1"}], "value": "Glutamate [NMDA] receptor subunit 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034100"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 1248, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042818837"}, {"type": "Transmembrane", "location": {"start": {"value": 703, "modifier": "EXACT"}, "end": {"value": 721, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 835, "modifier": "EXACT"}, "end": {"value": 861, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1023, "modifier": "EXACT"}, "end": {"value": 1044, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 573, "modifier": "EXACT"}, "end": {"value": 999, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00079"}]}, {"type": "Domain", "location": {"start": {"value": 585, "modifier": "EXACT"}, "end": {"value": 648, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor L-glutamate and glycine-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00918"}]}, {"type": "Region", "location": {"start": {"value": 1075, "modifier": "EXACT"}, "end": {"value": 1115, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1223, "modifier": "EXACT"}, "end": {"value": 1248, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1077, "modifier": "EXACT"}, "end": {"value": 1090, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34058.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34058.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154984", "properties": [{"key": "ProteinId", "value": "WRW34058.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000010", "properties": [{"key": "EntryName", "value": "glutamate receptor ionotropic, NMDA 1 isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000009", "properties": [{"key": "EntryName", "value": "Putative glutamate receptor ionotropic NMDA 2B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00918", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81324", "properties": [{"key": "EntryName", "value": "Voltage-gated potassium channels"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNSKNFLLIWFLIYLKVILFKHAETSGTHRFTIGAVLSSKQSREDFLKEMEIVQRELPANVVVQAKTVPMHTNPIQTANEVCSNLIPHQVHTVVVSHLPDLYTNKTFVTTDQNSASSVSFTCGFLGIPVISISNRNSALSDKQLHRTFLRTVPAFTNQAKIWLLLLRRLRYNNFILIHRADQEGLSALSKLNEWAHKLKMHMERVIAFESIFSGLKKDRNFIDDDKKFEQFYNRKNDNNNDNNFDEIISIPSVDNQVSQFSYNGTQLRTKFENVLRSTNCRVFLLYANTPEEAMYVIRVARSLNMFSPGFVWILSEQSLLSPSLAGAQLSDIPEGVLATKLSSKASQERSHIKDAVRLITNSLKKLTNEIENIASNSPPSDCNTTSYQNWGLGLKMLQLLRSEVINNGSTGRLAFDYKGDRLETEYEIVNIQYQKTNTDTKIEKKIVGLYYHNNLANMTQLQVNLSDIKWPGGVQEQPLGYFVPTHLNIVTLPEQPFVEKRKVLLKDKSKEYDLQQNIKDNYFNNNVNQIKMHHITNDSLNLNSINNLNKFLTINNTETPDYLLVQRSTSKLQYLCKSNEVHCPHYNQTTETTDHYCCSGYCIDLLLRIADALNFTFNLYQVQDLSYGSKKYLENRVEWNGLIGELLSKRADMAIGTLTINPERAKVIDFSKPFKYQGIGMLQLRVSKGTRLASFLQPFHGNLWILVLFSVHVVGLVLFLLDRLSPFGQSKFDENNEFNESDTCVNTDIDNSKTRASSSLAQQQTSQNINSFLKRKQSALSSLHNLFTSIDDSCGHDEEPGERPLTLSGAIWFSWGVLLNSGVGEKTPRSFSARVLGMVWAGFAMIVVASYTANLTAFLVLDSSETQIQNLDDARLRNPAEGFTYGTVKDSNVDLYFRGQIVLSNMYRLMEENNRATAQEAIDAVKKGDMNVFFWDSPRLEYEASRDCDLVISGETFGRSGYGIALQKNSFWTERVTLQILRLIESGFMETLDNKWILRTDKQCDKDLEGFPTTLGLENMAGVFKLVGVGILVSCGLIFIEITYKRKRLNRIRSLTSAKRCALTWRMKVKQRKETNTLRAKTISHTNIETKPNLENKKKTKAQNHQNKKNDNYNLQPNYSNYITNQQIYPFTVEQGVNDLRLMDSNKSAYLHHSGNPNVISPTFMNSSVNNLTNIKNKAGGFNQTPMPAAYNRSANSSAQIIRRTPGPPVKLKRADMYIATRPNKETYNDFDIPPPPPPPSHHRRGFK", "length": 1248, "molWeight": 142024, "crc64": "7014D61037B2258C", "md5": "88B29884A1AB800B499337232D5F3C6F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 3, "Domain": 2, "Region": 2, "Compositional bias": 1}, "uniParcId": "UPI003248D7AF"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DRD5", "uniProtkbId": "TX6A_POGMA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Pogonomyrmex maricopa", "commonName": "Maricopa harvester ant", "taxonId": 144040, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Hymenoptera", "Apocrita", "Aculeata", "Formicoidea", "Formicidae", "Myrmicinae", "Pogonomyrmex"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38110035"}], "value": "Myrmicitoxin(1)-Pm6a"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38110035"}], "value": "MYRTX(1)-Pm6a"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}], "value": "Toxin that causes a rapid and irreversible paralysis when intrathoracically injected into insects (blowflies). Does not cause spontaneous nocifensive behaviors by intraplantar injection in mice. Exhibits hemolytic and cytotoxic activities on HEK293 cells"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "38110035"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}], "value": "PD(50) [1 hour] is 9.9 nmol/g when intrathoracically injected into insects (blowfly L.caesar)"}], "commentType": "TOXIC DOSE"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the formicidae venom clade 3 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Propeptide", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000305"}], "featureId": "PRO_0000461263"}, {"type": "Peptide", "location": {"start": {"value": 38, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Myrmicitoxin(1)-Pm6a", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}], "featureId": "PRO_0000461264"}, {"type": "Modified residue", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Valine amide", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}]}], "keywords": [{"id": "KW-0027", "category": "PTM", "name": "Amidation"}, {"id": "KW-0528", "category": "Molecular function", "name": "Neurotoxin"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "38110035", "citationType": "journal article", "authors": ["Robinson S.D.", "Deuis J.R.", "Niu P.", "Touchard A.", "Mueller A.", "Schendel V.", "Brinkwirth N.", "King G.F.", "Vetter I.", "Schmidt J.O."], "citationCrossReferences": [{"database": "PubMed", "id": "38110035"}, {"database": "DOI", "id": "10.1016/j.jbc.2023.105577"}], "title": "Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants.", "publicationDate": "2024", "journal": "J. Biol. Chem.", "firstPage": "105577", "lastPage": "105577", "volume": "300"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "IDENTIFICATION BY MASS SPECTROMETRY", "SUBCELLULAR LOCATION", "SYNTHESIS OF 38-66", "BIOASSAY", "TOXIC DOSE", "AMIDATION AT VAL-66"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}, {"value": "Venom gland", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR128468", "properties": [{"key": "ProteinId", "value": "WMI02506.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "SMR", "id": "P0DRD5", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MRSLYLSFSLTIIFVLVIMHAEAKAISEPNAIAEADPGIFSALKTLGKILLPVILPTVAEKIKEKVG", "length": 67, "molWeight": 7222, "crc64": "33880ED7ED9A3717", "md5": "E72EB25D70D1D81C8BF89C07C3BFE6F3"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "TOXIC DOSE": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Propeptide": 1, "Peptide": 1, "Modified residue": 1}, "uniParcId": "UPI003086E038"}, "cluster_size": 2, "family": "Formicidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PAW7", "uniProtkbId": "A0AAU6PAW7_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20568.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20568.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20568.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20568.1"}], "value": "U_LCTX_82_Cm36", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20568.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480837", "properties": [{"key": "ProteinId", "value": "WXB20568.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "ETRTVSFSTVFIAAIFIMTKFLSLLLLVALIIAQASVDETTESDAFAD", "length": 48, "molWeight": 5211, "crc64": "CD92C9A213FC6F6E", "md5": "3B7520DB7E3805AF0C5BAAA16F2ADC91"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D3C870"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LW25", "uniProtkbId": "A0AAN0LW25_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06421.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00071250"}], "value": "Gamma-aminobutyric acid receptor subunit beta"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010180"}], "value": "Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 884, "modifier": "EXACT"}}, "description": "Gamma-aminobutyric acid receptor subunit beta", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "featureId": "PRO_5042671590"}, {"type": "Transmembrane", "location": {"start": {"value": 255, "modifier": "EXACT"}, "end": {"value": 278, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 290, "modifier": "EXACT"}, "end": {"value": 309, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 321, "modifier": "EXACT"}, "end": {"value": 342, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 851, "modifier": "EXACT"}, "end": {"value": 871, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Domain", "location": {"start": {"value": 48, "modifier": "EXACT"}, "end": {"value": 251, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel ligand-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02931"}]}, {"type": "Domain", "location": {"start": {"value": 262, "modifier": "EXACT"}, "end": {"value": 434, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel transmembrane", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02932"}]}, {"type": "Region", "location": {"start": {"value": 711, "modifier": "EXACT"}, "end": {"value": 734, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 713, "modifier": "EXACT"}, "end": {"value": 734, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023214"}], "id": "KW-0868", "category": "Ligand", "name": "Chloride"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023173"}], "id": "KW-0869", "category": "Molecular function", "name": "Chloride channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06421.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP191260", "properties": [{"key": "ProteinId", "value": "WTM06421.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0034707", "properties": [{"key": "GoTerm", "value": "C:chloride channel complex"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005254", "properties": [{"key": "GoTerm", "value": "F:chloride channel activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005230", "properties": [{"key": "GoTerm", "value": "F:extracellular ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0099095", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic anion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0004888", "properties": [{"key": "GoTerm", "value": "F:transmembrane signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd19008", "properties": [{"key": "EntryName", "value": "LGIC_ECD_GABAR_RDL-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd19049", "properties": [{"key": "EntryName", "value": "LGIC_TM_anion"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.70.170.10:FF:000021", "properties": [{"key": "EntryName", "value": "Gamma-aminobutyric acid receptor isoform 3b"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.20.58.390:FF:000067", "properties": [{"key": "EntryName", "value": "Glycine receptor subunit alpha-2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.70.170.10", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel ligand-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.390", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR006028", "properties": [{"key": "EntryName", "value": "GABAA/Glycine_rcpt"}]}, {"database": "InterPro", "id": "IPR006202", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd"}]}, {"database": "InterPro", "id": "IPR036734", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd_sf"}]}, {"database": "InterPro", "id": "IPR006201", "properties": [{"key": "EntryName", "value": "Neur_channel"}]}, {"database": "InterPro", "id": "IPR036719", "properties": [{"key": "EntryName", "value": "Neuro-gated_channel_TM_sf"}]}, {"database": "InterPro", "id": "IPR038050", "properties": [{"key": "EntryName", "value": "Neuro_actylchol_rec"}]}, {"database": "InterPro", "id": "IPR006029", "properties": [{"key": "EntryName", "value": "Neurotrans-gated_channel_TM"}]}, {"database": "InterPro", "id": "IPR018000", "properties": [{"key": "EntryName", "value": "Neurotransmitter_ion_chnl_CS"}]}, {"database": "NCBIfam", "id": "TIGR00860", "properties": [{"key": "EntryName", "value": "LIC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR18945", "properties": [{"key": "EntryName", "value": "NEUROTRANSMITTER GATED ION CHANNEL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02931", "properties": [{"key": "EntryName", "value": "Neur_chan_LBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02932", "properties": [{"key": "EntryName", "value": "Neur_chan_memb"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00253", "properties": [{"key": "EntryName", "value": "GABAARECEPTR"}]}, {"database": "PRINTS", "id": "PR00252", "properties": [{"key": "EntryName", "value": "NRIONCHANNEL"}]}, {"database": "SUPFAM", "id": "SSF90112", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane pore"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63712", "properties": [{"key": "EntryName", "value": "Nicotinic receptor ligand binding domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00236", "properties": [{"key": "EntryName", "value": "NEUROTR_ION_CHANNEL"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQCNLLYFINILLLQLVVATNNTSLEDDIEKTSNGNNTEEDLGAHISKILNNFFTSGYDKRVRPNYGGKPVEVGVTMFVISISSVSEVQMDFTSDFYFRQYWKDNRLSFPPTDGITQIFVGAEVSERIWLPDTFFANEKSAYFHIATTKNTFLRITSSGEVLRSIRLTVTASCPMDLQYFPMDRQLCSIEIESYGYSMSDIKYKWQPVANSVGLAKELSLPQFKVLGHRQKEKVIDLTTGNYSRLICEIQFARSLGFYLIQIYIPASLIVVISWVSFWLHRNATPARVSLGVTTVLTMTTLMSSTNAQLPKISYIKSIDVFLGTCFVMVFGSLLEYAIVGYLGKRISMRKSRNEQINKAVLSKLEERKQAANKFLAIKNEETNQLTTNPSIIKMPQTQSPSFCQSSSNVLNTFPVEHQNNQSFNEQSYQPLNSSFNDIHSQNLALRTRSQSADNYIPPINLNQKFDNLNDTLNQASSNFLQPIYKNSYYNLPFSHSTSQFHNPFFYKNDYYNNHSVHNFQNPNLSTSPISDRPPNYKINHLHNYKYPYHQSCYNKLQNFPDTLKFNYLNSFYNSSNHLFNPNLSDNKLSYNRQSYPYYRRNGNLDYKPSHYTSVQNNSFQYSSRNRLNTQLSAYDPSLEESRYSKYASLSKKKQNFLKEAEKSKIDKKESENLQNQQEITQQIQNQRYIDKTKHNLTSNNQKLNSEKLNETLSSKSINHSNSNRNKNHNEFSNSNLNDFSDANIINSTQINSSNIPLQTTNQSVNSVNLNQRQEINQVEAFKSKNKSLDYEPLNATTQLSSNHRSTITATSTRTGARFNKFAKNLLMLGSCKNPNKICGLSPSDIDKYSRVIFPVCFICFNLMYWVIYLHISDDIKADLVPLGS", "length": 884, "molWeight": 101569, "crc64": "B4A63FACE95DCEEF", "md5": "969F826702AEAB4158DAC7009DB0CB5F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 4, "Domain": 2, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI003244086E"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2Z4", "uniProtkbId": "A0AA96S2Z4_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50089.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50089.1"}], "value": "Tenascin-like protein"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 219, "modifier": "EXACT"}}, "description": "Fibrinogen C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51406"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50089.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460166", "properties": [{"key": "ProteinId", "value": "WNS50089.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "3.90.215.10", "properties": [{"key": "EntryName", "value": "Gamma Fibrinogen, chain A, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036056", "properties": [{"key": "EntryName", "value": "Fibrinogen-like_C"}]}, {"database": "InterPro", "id": "IPR014716", "properties": [{"key": "EntryName", "value": "Fibrinogen_a/b/g_C_1"}]}, {"database": "InterPro", "id": "IPR002181", "properties": [{"key": "EntryName", "value": "Fibrinogen_a/b/g_C_dom"}]}, {"database": "InterPro", "id": "IPR050373", "properties": [{"key": "EntryName", "value": "Fibrinogen_C-term_domain"}]}, {"database": "PANTHER", "id": "PTHR19143", "properties": [{"key": "EntryName", "value": "FIBRINOGEN/TENASCIN/ANGIOPOEITIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00147", "properties": [{"key": "EntryName", "value": "Fibrinogen_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00186", "properties": [{"key": "EntryName", "value": "FBG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56496", "properties": [{"key": "EntryName", "value": "Fibrinogen C-terminal domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51406", "properties": [{"key": "EntryName", "value": "FIBRINOGEN_C_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLSAVSRCYFQEFTAVYRGGSCSAWYPYMDCCYLMRLFPYVSNGVYEIGDPCVRNFLHPYSLRMHTKCDMFAAGGGWTVIMQRNTSDSSGSSSVDFSSKGWDDYENGFGSLSGDFWFGLANLRCITQRETYELRVELTFADGSSGDIIYPDFQVDTRANGYKLTFGAPVGNATVNDAFARMTNFIFQTSDFVRSSTCKGKIEGGFWAPGNGACSIRTNLHASVAMWMGKQVYSASMMLRAVRCGNIRDCD", "length": 250, "molWeight": 27853, "crc64": "30FB5DA25F02907F", "md5": "BF65326E38BA7DAB0C4CEB97C88AD351"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI002B311339"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8BDH4", "uniProtkbId": "A0AAU8BDH4_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Conopomorpha sinensis", "commonName": "litch fruit borer", "taxonId": 940481, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD10482.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Tineoidea", "Gracillariidae", "Conopomorpha"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 140, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 220, "modifier": "EXACT"}, "end": {"value": 238, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 299, "modifier": "EXACT"}, "end": {"value": 318, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 325, "modifier": "EXACT"}, "end": {"value": 347, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 390, "modifier": "EXACT"}, "end": {"value": 411, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5PCR16OJ21JA0", "citationType": "submission", "authors": ["Chang H."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD10482.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP937555", "properties": [{"key": "ProteinId", "value": "XCD10482.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSTVDRRKNHLPPTLKLKNMKMLVYVLNGIGAFPWEAFRERRPFLLFITYFMPFETLFVVYMLTNFVYHNVRVTDLATRSQCAITLILQCCQLIRTTRRLLPAYGYVFKTFFEKNHLYYLKDVSPFHNDIYNKVEKMTNFYTYVEIFFIIMLPGSMVAINVFVNYQNGLFSPNPPANVTWSRISYWKLPFIDTEPNIYIYLTIEYLGSQICALSTLQLDLVIAVLVFHLIGHIVVMVHEVETLEVPVDEAAEAQQLVYNDEQNKILSDKIVRVVHHHVDVIAFCDMISDFSGVPVMCNYFYQLVCGCLLLILTTSMDFKSAAQFTVITASTFTELVVISFIFEMVVITSKNLPHALYSSAWEKASCRNRRSVFLMLLRMQQPLQVKGLDIVTFGFDTMIAILKTTFSYFIFLRSFT", "length": 416, "molWeight": 48287, "crc64": "9350D104F20BDB76", "md5": "68F98C8F50D77F56F9A5869D2B113374"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 6}, "uniParcId": "UPI0035D280D1"}, "cluster_size": 1, "family": "Gracillariidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9XYY0", "uniProtkbId": "A0AAT9XYY0_PINTA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Pinus taeda", "commonName": "Loblolly pine", "taxonId": 3352, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Pinopsida", "Pinidae", "Conifers I", "Pinales", "Pinaceae", "Pinus", "Pinus subgen. Pinus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}], "value": "Endoribonuclease dicer-like protein 3"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}], "value": "DCL3"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001946"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}]}, {"commentType": "COFACTOR", "cofactors": [{"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001936"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00035116"}], "value": "Belongs to the helicase family. Dicer subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 2, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "Helicase C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51194"}]}, {"type": "Domain", "location": {"start": {"value": 181, "modifier": "EXACT"}, "end": {"value": 274, "modifier": "EXACT"}}, "description": "Dicer dsRNA-binding fold", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51327"}]}, {"type": "Domain", "location": {"start": {"value": 472, "modifier": "EXACT"}, "end": {"value": 601, "modifier": "EXACT"}}, "description": "PAZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50821"}]}, {"type": "Domain", "location": {"start": {"value": 626, "modifier": "EXACT"}, "end": {"value": 798, "modifier": "EXACT"}}, "description": "RNase III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50142"}]}, {"type": "Domain", "location": {"start": {"value": 839, "modifier": "EXACT"}, "end": {"value": 987, "modifier": "EXACT"}}, "description": "RNase III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50142"}]}, {"type": "Domain", "location": {"start": {"value": 1044, "modifier": "EXACT"}, "end": {"value": 1080, "modifier": "EXACT"}}, "description": "DRBM", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50137"}]}, {"type": "Domain", "location": {"start": {"value": 1320, "modifier": "EXACT"}, "end": {"value": 1394, "modifier": "EXACT"}}, "description": "DRBM", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50137"}]}, {"type": "Region", "location": {"start": {"value": 275, "modifier": "EXACT"}, "end": {"value": 294, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 279, "modifier": "EXACT"}, "end": {"value": 289, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022759"}], "id": "KW-0255", "category": "Molecular function", "name": "Endonuclease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022806"}], "id": "KW-0347", "category": "Molecular function", "name": "Helicase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022842"}], "id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023211"}], "id": "KW-0464", "category": "Ligand", "name": "Manganese"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022722"}], "id": "KW-0540", "category": "Molecular function", "name": "Nuclease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00657"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023158"}], "id": "KW-0943", "category": "Biological process", "name": "RNA-mediated gene silencing"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-134CKBQBAMOI5", "citationType": "submission", "authors": ["Bragg Z.", "Rieske L.K."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}], "value": "7-56xOP_9", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}], "value": "Whole plant", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-CRD440VTN3173", "citationType": "journal article", "authors": ["Bragg Z.", "Rieske L.K."], "title": "Identification of RNAi-Related Genes and Transcriptome Assembly of Loblolly Pine (Pinus taeda, L.) Seedlings Exposed to Insect-Specific dsRNA.", "publicationDate": "2024", "journal": "Forests", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}], "value": "7-56xOP_9", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}], "value": "Whole plant", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66619.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR466154", "properties": [{"key": "ProteinId", "value": "WLZ66619.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004386", "properties": [{"key": "GoTerm", "value": "F:helicase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004525", "properties": [{"key": "GoTerm", "value": "F:ribonuclease III activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0010267", "properties": [{"key": "GoTerm", "value": "P:ta-siRNA processing"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "CDD", "id": "cd00048", "properties": [{"key": "EntryName", "value": "DSRM_SF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00593", "properties": [{"key": "EntryName", "value": "RIBOc"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "1.10.1520.10:FF:000008", "properties": [{"key": "EntryName", "value": "Dicer-like 104"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.1520.10:FF:000004", "properties": [{"key": "EntryName", "value": "Endoribonuclease dicer-like 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.380:FF:000001", "properties": [{"key": "EntryName", "value": "Endoribonuclease dicer-like 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.160.20", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.30.160.380", "properties": [{"key": "EntryName", "value": "Dicer dimerisation domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.170.260.10", "properties": [{"key": "EntryName", "value": "paz domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.1520.10", "properties": [{"key": "EntryName", "value": "Ribonuclease III domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR038248", "properties": [{"key": "EntryName", "value": "Dicer_dimer_sf"}]}, {"database": "InterPro", "id": "IPR005034", "properties": [{"key": "EntryName", "value": "Dicer_dimerisation_dom"}]}, {"database": "InterPro", "id": "IPR014720", "properties": [{"key": "EntryName", "value": "dsRBD_dom"}]}, {"database": "InterPro", "id": "IPR001650", "properties": [{"key": "EntryName", "value": "Helicase_C-like"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR003100", "properties": [{"key": "EntryName", "value": "PAZ_dom"}]}, {"database": "InterPro", "id": "IPR036085", "properties": [{"key": "EntryName", "value": "PAZ_dom_sf"}]}, {"database": "InterPro", "id": "IPR000999", "properties": [{"key": "EntryName", "value": "RNase_III_dom"}]}, {"database": "InterPro", "id": "IPR036389", "properties": [{"key": "EntryName", "value": "RNase_III_sf"}]}, {"database": "PANTHER", "id": "PTHR14950", "properties": [{"key": "EntryName", "value": "DICER-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14950:SF46", "properties": [{"key": "EntryName", "value": "ENDORIBONUCLEASE DICER HOMOLOG 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03368", "properties": [{"key": "EntryName", "value": "Dicer_dimer"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14709", "properties": [{"key": "EntryName", "value": "DND1_DSRM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00035", "properties": [{"key": "EntryName", "value": "dsrm"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00271", "properties": [{"key": "EntryName", "value": "Helicase_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02170", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00636", "properties": [{"key": "EntryName", "value": "Ribonuclease_3"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00358", "properties": [{"key": "EntryName", "value": "DSRM"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00490", "properties": [{"key": "EntryName", "value": "HELICc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00949", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00535", "properties": [{"key": "EntryName", "value": "RIBOc"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF54768", "properties": [{"key": "EntryName", "value": "dsRNA-binding domain-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF101690", "properties": [{"key": "EntryName", "value": "PAZ domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF69065", "properties": [{"key": "EntryName", "value": "RNase III domain-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS51327", "properties": [{"key": "EntryName", "value": "DICER_DSRBF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50137", "properties": [{"key": "EntryName", "value": "DS_RBD"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS51194", "properties": [{"key": "EntryName", "value": "HELICASE_CTER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50821", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00517", "properties": [{"key": "EntryName", "value": "RNASE_3_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50142", "properties": [{"key": "EntryName", "value": "RNASE_3_2"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "LLSYRQVKEIRCIIFVDRVIAATVISRLIKELDCLSYISSDYLAGETGLLDIIGPKPKQNTLDLFRTGKVNVLVTTNVTEEGIDVQDCRSIIRFDLPSSVRSYIQSRGRARRPESDYIVLLERSNEKQLNLFYNVIRSENSMRNLSLNRSHIPLTPKASVAKEAALYSVSRTGASVNCDSSVSFIYKYCSKLPGDKYYLPRPEFVFRSVEGEENLHVCTLRLPPNAPFQEVLGPPSNRQIHAKQLACLEACKRLHEVGAVDDYLIPITEAVPEEEETVNSKGKNATGAGTTKRKELHTKAKAKALCGSWGKEPNGVALQIYKLVFMAQDNDEKAYADFALFIEGTLDDDVANAEIDLHLTAGRVVKARFAPSGKMHLNSIQITDAKAFQEILYNGIFDKLIKRTKSSNGVDVVMKNILGTKKIKRAWASSNIYFLLPLESNQGSFHDTTVNIDWKCISKCADVARAFEYYRTRLQVGEDDSSGIYLATGPILTADLIDKAIVTIHTGKIYCVTDVLHDKTAESPFPELQHSEVPSYVSYSDYFQKKYGRNLNYLKQPLLQLKQSHRPHNLLTRHVEKSQGKACDVRPNCIEMPPELCLNLGVPSSVIRSLYLVPSVMHRMASLMLATQLRQEIQECSNCPFIPATLIMEAVTTMRCLESFSLERLELLGDSVLKYAVSSHLFLKYNKKHEGQLTARRSWAICNASLHRVAILRNLPGYIRDEPFDPRRWFAPGTLSPKSVPCCCDSNFLKESVNGMPEMEGKTVKIGKTCDKGHRWMCSKTIADSVEALIGAYLVGKDLDAALKFMSWMNIEVASEPELVTSAFECASVHPSVLRSVNIHGLESKLGYVFHNKGLLVEAITHASQQDFEGGCCYQRLEFLGDSVLDLLITQHLFSEHPDLPPGVLTDLRSAAVNNKKFAHVSVKHNLHQYLRHGSGILLGQITRFVKAVQEQESKNQSTSLGLGVQAPKVLGDLVESIAGAILIDSKFDIKRVWEIMRPLLSPIVTPETLDLHPLREVSELCHLKGYPIVWKKSTQEGKLVIATMEVAVEDNTLIGKGCKTSKKSAKEKAAREILKQMEERGICHPRHQRLTGREALDTEARGTIKRSLEESVSPEGISRKKTRLLNTSEECILDCPWKNLNSRKSLHTGEGTIRQQNPDKGIAPLIIAERCKNKLEANQTQEFLPRKKARVIMTLGNSETSQDTGNPSVAYNQRCSPSDEGGNNFGASYYNINRHETNFGESNNNNNGREAVSSLLTAVENKRLASDNSNGSEDMLGASYNNNNGSESVSTPAIPVANKLPLNSGFEAACVSLSMRKGGPRSSLYELCKRMKWAVPDFQLVEQERLPQTTRFVFRVVLHIPNREKLLVQGDKKIDKNSAKDSAALLMLHELEKQGLCFIKQ", "length": 1402, "molWeight": 156469, "crc64": "99A926CD18429965", "md5": "B7A2F1F58DC8A90DB8031957F102269F"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 2, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 7, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D39E04"}, "cluster_size": 1, "family": "Pinaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTH1", "uniProtkbId": "A0AAT9UTH1_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41610.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41610.1"}], "value": "Cytochrome P450 6PW3"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 438, "modifier": "EXACT"}, "end": {"value": 438, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41610.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117170", "properties": [{"key": "ProteinId", "value": "WIM41610.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000042", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292:SF100", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 6A16, ISOFORM B-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSEFMWLPLVLLPMIIFWLIKYYYDYWKRRGIPYVESHPLDLDWYKSAGIDYYAKIYRQLEGHKFGGFFSRFAPKLMIRDPELIKNVLIKDFDYFHDRGDTTFDENEPLTMNMFSAPGTLWRNLRTRLTPTFTSGKMKYMFNLVQECAEELVQAVDSHIQNDTTIDVKNYVTRYSIEVISSCAFGLKTYSIKDGHSRFAAMASKIFEGKLSARIVYLTRSVCPKLKEILRVPFIGKTTSEFFLKLTNDVVEHRKASNSSRNDFVQILINLQDDKKMGTIEDEFTLTDDLMSAQCFLFFVAGYDTSSMTISFALYELAANIEIQKKLQNEIDSFMEEHDDQVSYEMVHNMPYLHKVVSESLRKYSINGTLMRVCVKKYQIPGTEVYIDKGTEVFIPVSGLHTDERYFPDPERFLPERFEDRNPEFRDAYLPFGAGPRSCIGFRFALMSVKLALIYLLRNFNLELCTETRYPFEFAPLKIVTSVKHEIFLTFNKR", "length": 493, "molWeight": 57714, "crc64": "22ED3FF5217DBFC4", "md5": "59C88DBB45DBEE9215A9472A23954195"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D343E0"}, "cluster_size": 5, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7Z3", "uniProtkbId": "A0AAN0N7Z3_DUGJA", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Dugesia japonica", "commonName": "Planarian", "taxonId": 6161, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL62550.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Platyhelminthes", "Rhabditophora", "Seriata", "Tricladida", "Continenticola", "Geoplanoidea", "Dugesiidae", "Dugesia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL62550.1"}], "value": "GLIPR1-like protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL62550.1"}], "value": "Glipr1"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00479"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 323, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042989091"}, {"type": "Domain", "location": {"start": {"value": 28, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "Fibronectin type-II", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51092"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8OE96CIP0SB1I", "citationType": "submission", "authors": ["Ma K."], "title": "Identification of a GLIPR1-like gene in planarian Dugesia japonica.", "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZL62550.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP680536", "properties": [{"key": "ProteinId", "value": "WZL62550.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd05380", "properties": [{"key": "EntryName", "value": "CAP_euk"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.33.10", "properties": [{"key": "EntryName", "value": "CAP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.10.10.10", "properties": [{"key": "EntryName", "value": "Fibronectin, type II, collagen-binding"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR014044", "properties": [{"key": "EntryName", "value": "CAP_dom"}]}, {"database": "InterPro", "id": "IPR035940", "properties": [{"key": "EntryName", "value": "CAP_sf"}]}, {"database": "InterPro", "id": "IPR001283", "properties": [{"key": "EntryName", "value": "CRISP-related"}]}, {"database": "InterPro", "id": "IPR000562", "properties": [{"key": "EntryName", "value": "FN_type2_dom"}]}, {"database": "InterPro", "id": "IPR036943", "properties": [{"key": "EntryName", "value": "FN_type2_sf"}]}, {"database": "InterPro", "id": "IPR013806", "properties": [{"key": "EntryName", "value": "Kringle-like"}]}, {"database": "PANTHER", "id": "PTHR10334", "properties": [{"key": "EntryName", "value": "CYSTEINE-RICH SECRETORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00188", "properties": [{"key": "EntryName", "value": "CAP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00040", "properties": [{"key": "EntryName", "value": "fn2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00059", "properties": [{"key": "EntryName", "value": "FN2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00198", "properties": [{"key": "EntryName", "value": "SCP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57440", "properties": [{"key": "EntryName", "value": "Kringle-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55797", "properties": [{"key": "EntryName", "value": "PR-1-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51092", "properties": [{"key": "EntryName", "value": "FN2_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MINYQFMLLLASFLSVIRAQEAYRPKTVNGEFCMIPYEYQGKFYHDCITEGDTKPWCRPSEGQWGYCANVPDFSSCKMAAPTITADEIKQILDLANNIRSKEPALRMAKLRWNTELAHRAQHMSNQCRLGSDNTNLCTSQAPMGQISYATMSSVVQPKKWPQFILEFFNKKSTYDFETNKCTAQYCNGYKQLVNAKTTDIGCAMSSCNKDSMFADYYFCNFYPPIYQDRPYEKGDSGCNSCFRLNDAYTYQCNKSLCEICDKPSSDCKGKEELQKAVEAGQVCDDLDADFCNLNASICPNIDLLPDEYKVMVSTKCKKTCKLC", "length": 323, "molWeight": 36759, "crc64": "5625EBA0A4625974", "md5": "D44AE1FF6A8EF6CD3D794961C0D42CC7"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI003251AA4F"}, "cluster_size": 1, "family": "Dugesiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VG30", "uniProtkbId": "A0AAU7VG30_PONPI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pongamia pinnata", "commonName": "Pongam oil-tree", "synonyms": ["Millettia pinnata"], "taxonId": 56065, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75473.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Fabales", "Fabaceae", "Papilionoideae", "50 kb inversion clade", "NPAAA clade", "indigoferoid/millettioid clade", "Millettieae", "Pongamia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75473.1"}], "value": "Kunitz Trypsin Inhibitor"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75473.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 74, "modifier": "EXACT"}, "end": {"value": 74, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75473.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9ET05JM09V3CI", "citationType": "submission", "authors": ["Mehra A.", "Mazumdar-Leighton S."], "title": "Mature leaf cDNA fragments from Pongamia pinnata.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW75473.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP908485", "properties": [{"key": "ProteinId", "value": "XBW75473.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004866", "properties": [{"key": "GoTerm", "value": "F:endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "2.80.10.50", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR011065", "properties": [{"key": "EntryName", "value": "Kunitz_inhibitor_STI-like_sf"}]}, {"database": "InterPro", "id": "IPR002160", "properties": [{"key": "EntryName", "value": "Prot_inh_Kunz-lg"}]}, {"database": "Pfam", "id": "PF00197", "properties": [{"key": "EntryName", "value": "Kunitz_legume"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50386", "properties": [{"key": "EntryName", "value": "STI-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "ETCPLTVVQTRDELSKGLPVSIASPYGIAYVYEGLIVDIGFTAVPICAPLPSKWTIINGLSEEPVVKLTGYENT", "length": 74, "molWeight": 7939, "crc64": "2A56300C27D4E5AC", "md5": "68D0E64EB371632A8C8B269D1A6AEEAC"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D2C6B3"}, "cluster_size": 1, "family": "Fabaceae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P9WEK1", "uniProtkbId": "AMAA_APIMO", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Apiospora montagnei", "commonName": "Sphaeria apiospora", "taxonId": 255776, "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Pezizomycotina", "Sordariomycetes", "Xylariomycetidae", "Amphisphaeriales", "Apiosporaceae", "Apiospora"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36702957"}], "value": "Arginine-containing cyclodipeptide synthase amaA"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36702957"}], "value": "RCDPS amaA"}], "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}], "value": "6.3.2.-"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "36702957"}], "value": "amaA"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}, {"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "36702957"}], "value": "Arginine-containing cyclodipeptide synthase; part of the cluster that mediates the biosynthesis of a highly modified cyclo-arginine-proline dipeptide (cRP) (PubMed:36702957). Within the pathway, amaA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Pro diketopiperazine (cRW) from L-arginyl-tRNA(Arg) + L-prolyl-tRNA(Pro) (PubMed:36702957). Additional enzymes from the cluster then further modify the cyclo-Arg-Pro diketopiperazine (cRW) scaffold (Probable)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "L-prolyl-tRNA(Pro) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-prolyl) + tRNA(Pro) + tRNA(Arg) + 2 H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:80423"}, {"database": "Rhea", "id": "RHEA-COMP:9658"}, {"database": "Rhea", "id": "RHEA-COMP:9673"}, {"database": "Rhea", "id": "RHEA-COMP:9700"}, {"database": "Rhea", "id": "RHEA-COMP:9702"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:78442"}, {"database": "ChEBI", "id": "CHEBI:78513"}, {"database": "ChEBI", "id": "CHEBI:78532"}, {"database": "ChEBI", "id": "CHEBI:231491"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:80424"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}]}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "36702957"}], "value": "Secondary metabolite biosynthesis"}], "commentType": "PATHWAY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P9WEJ7"}], "value": "The conserved DDXXE motif is essential for catalytic activity"}], "commentType": "DOMAIN"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the arginine-containing cyclodipeptide synthase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 549, "modifier": "EXACT"}}, "description": "Arginine-containing cyclodipeptide synthase amaA", "featureId": "PRO_0000461005"}, {"type": "Motif", "location": {"start": {"value": 445, "modifier": "EXACT"}, "end": {"value": 449, "modifier": "EXACT"}}, "description": "Conserved DDXXE motif", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P9WEJ7"}]}], "keywords": [{"id": "KW-0436", "category": "Molecular function", "name": "Ligase"}], "references": [{"referenceNumber": 1, "citation": {"id": "36702957", "citationType": "journal article", "authors": ["Yee D.A.", "Niwa K.", "Perlatti B.", "Chen M.", "Li Y.", "Tang Y."], "citationCrossReferences": [{"database": "PubMed", "id": "36702957"}, {"database": "DOI", "id": "10.1038/s41589-022-01246-6"}], "title": "Genome mining for unknown-unknown natural products.", "publicationDate": "2023", "journal": "Nat. Chem. Biol.", "firstPage": "633", "lastPage": "640", "volume": "19"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "FUNCTION", "CATALYTIC ACTIVITY", "PATHWAY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP622864", "properties": [{"key": "ProteinId", "value": "WCB22923.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016874", "properties": [{"key": "GoTerm", "value": "F:ligase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MVSISKSLVADICVGSSPPTVRFVTLLENHDISNTTFPSLSGVLAQYGSSLQGPAGLQHVGLAQDQKYQHALTKGLKAVEKLQHFLDGPAPMSGDPVVLRCSSARSSTLLEITDETITSGPPCAGAAREREGITSFHRMKFHLPKHVGCVQDVHETSSQMLHLSCDGLRSEDTLFDRFGRWSRDHVTIVSGMCLFSDKIMRDAVQGDGKLDVSKLSSQEPTLYELEIIARSSSAIADVASHILGKNGAAKPIPLEIVLDAPSWHYFQVVHGNLASGHCTPAEALDWLQAVELRCEQVTTVFENSVRHEMGLRGVPAGFYHILAAPGTAGVGTSIRQALTSGMVPDIADCMDAICEVEGERWAMFYSLIPEKDRPCDFRSLGNLFYIYEVVRPALAAKNGSTAAELEVSGPNSALDDSSSSGHSDILDSALHLKANVERPLIMSIDDRAERKIYSKAQAFIKKIRRAPQIPSHPLLLELYSARRVFINGNTGGDSLYWNDSSPHPLRMNTTAGSPELEAFGVIRNLYGNDCAQNLQRWFSEAGVNVSGHT", "length": 549, "molWeight": 59662, "crc64": "16D05166C78F6B35", "md5": "73F69497290CE4BC0A24301BE27DF7C6"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 1, "PATHWAY": 1, "DOMAIN": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Motif": 1}, "uniParcId": "UPI0027AAD960"}, "cluster_size": 2, "family": "Apiosporaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N6G0", "uniProtkbId": "A0AAJ6N6G0_9CYAN", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Anthocerotibacter panamensis", "taxonId": 2857077, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8IMM"}], "lineage": ["Bacteria", "Bacillati", "Cyanobacteriota", "Cyanophyceae", "Gloeobacterales", "Anthocerotibacteraceae", "Anthocerotibacter"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8IML"}, {"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8IMM"}], "value": "CpcJ"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004445"}], "value": "Cellular thylakoid membrane", "id": "SL-0045"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004445"}], "value": "Peripheral membrane protein", "id": "SL-9903"}, "orientation": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004445"}], "value": "Cytoplasmic side", "id": "SL-9910"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00775"}], "value": "Belongs to the phycobilisome linker protein family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 35, "modifier": "EXACT"}, "end": {"value": 215, "modifier": "EXACT"}}, "description": "PBS-linker", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51445"}]}, {"type": "Domain", "location": {"start": {"value": 319, "modifier": "EXACT"}, "end": {"value": 498, "modifier": "EXACT"}}, "description": "PBS-linker", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51445"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IML"}, {"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IMM"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00775"}], "id": "KW-0042", "category": "Cellular component", "name": "Antenna complex"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00775"}], "id": "KW-0605", "category": "Cellular component", "name": "Phycobilisome"}], "references": [{"referenceNumber": 1, "citation": {"id": "38049400", "citationType": "journal article", "authors": ["Jiang H.W.", "Wu H.Y.", "Wang C.H.", "Yang C.H.", "Ko J.T.", "Ho H.C.", "Tsai M.D.", "Bryant D.A.", "Li F.W.", "Ho M.C.", "Ho M.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "38049400"}, {"database": "DOI", "id": "10.1038/s41467-023-43646-9"}], "title": "A structure of the relict phycobilisome from a thylakoid-free cyanobacterium.", "publicationDate": "2023", "journal": "Nat. Commun.", "firstPage": "8009", "lastPage": "8009", "volume": "14"}, "referencePositions": ["STRUCTURE BY ELECTRON MICROSCOPY (2.74 ANGSTROMS)"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IML"}, {"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IMM"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8IML", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "2.74 A"}, {"key": "Chains", "value": "3=1-531"}]}, {"database": "PDB", "id": "8IMM", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "2.76 A"}, {"key": "Chains", "value": "3=1-531"}]}, {"database": "SMR", "id": "A0AAJ6N6G0", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0030089", "properties": [{"key": "GoTerm", "value": "C:phycobilisome"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0031676", "properties": [{"key": "GoTerm", "value": "C:plasma membrane-derived thylakoid membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015979", "properties": [{"key": "GoTerm", "value": "P:photosynthesis"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR001297", "properties": [{"key": "EntryName", "value": "PBS_linker_dom"}]}, {"database": "PANTHER", "id": "PTHR34011:SF6", "properties": [{"key": "EntryName", "value": "PHYCOBILIPROTEIN APCE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR34011", "properties": [{"key": "EntryName", "value": "PHYCOBILISOME 32.1 KDA LINKER POLYPEPTIDE, PHYCOCYANIN-ASSOCIATED, ROD 2-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00427", "properties": [{"key": "EntryName", "value": "PBS_linker_poly"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS51445", "properties": [{"key": "EntryName", "value": "PBS_LINKER"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MPAVVADQYLAMAKELAASRFGGFTKENIPSPMAQPESYGRDRLGIAAVATENPKVTLRAPFTSEEFQGALYAIYRHIFGNTYVMESERPTTAESQLKDGRITVRGFIRLLAKSEVYKSRFFQKTSQNRFIELSHKLLLGRAPYDQAEISYHLDLWNTQGYDAEIDSYVDSEEYLDFFGEDTVPFLRDFKYQTGQQGVGYSRLLNLYDGYAGSDTDRAQSGQKARLNGTIAQAEPGSIERPSALQDTWKFANPNYRNAKPPMVKALALEPFLDMARELTPKPPTRQVDLLFLNMAKDLTSVSRAEWLAKSYTQPSRYQQTETFGQERIGAVGAIETPRINLRAPFTSEEFQGALYAIYRHIFGNTYVMESERPTTAESQLKDGRITVRGFIRLLAKSEVYKSRFFQKTSQNRFIELSHKLLLGRAPYDQAEISYHLDLWNTQGYDAEIDSYVDSEEYLDFFGEDTVPYFRGFKYQTGQSAEGFNRLVRLYDGWAGSDTDRNVGGQVARLTANLTRGGSGLEPFIVMANSRR", "length": 531, "molWeight": 60269, "crc64": "435E42C39D2F8267", "md5": "4958C6B44B0CE15A1D96396008A6D345"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2}, "uniParcId": "UPI001C40679A"}, "cluster_size": 1, "family": "Anthocerotibacteraceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96UTL0", "uniProtkbId": "A0AA96UTL0_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29080.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29080.1"}], "value": "CREWS-B"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 1300, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041636021"}, {"type": "Domain", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 211, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 292, "modifier": "EXACT"}, "end": {"value": 375, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 458, "modifier": "EXACT"}, "end": {"value": 535, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 622, "modifier": "EXACT"}, "end": {"value": 703, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 721, "modifier": "EXACT"}, "end": {"value": 894, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 916, "modifier": "EXACT"}, "end": {"value": 1093, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 1111, "modifier": "EXACT"}, "end": {"value": 1282, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29080.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651417", "properties": [{"key": "ProteinId", "value": "WNX29080.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF20", "properties": [{"key": "EntryName", "value": "PH DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "PRINTS", "id": "PR00453", "properties": [{"key": "EntryName", "value": "VWFADOMAIN"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "7"}]}], "sequence": {"value": "MLLIHLLLVLIIPCGYVPAGAVRTSVQRCQRRMDIVFLVDTSYTMYPNEFPGELKFVQDVIGQFEVSPSNTRVAVVSYSQGVREEFGLDQYQSLDTVLKAVGNIQYTRGDRLESHKAIEYAHKLLLQQSRHGAVPVIIFITGGKTSYVQQTLEVADEVRTKDILLFSVGVGLSLAMEELGKIATQNTNQFVYSAESFNKSSTIVQSLGPEVCKATPSVTQTADTCMRPTDLVFAIYSPHTSARGSSRDENNFIEGLLNFFHQSPTTTHVSMVTSREDSHDAIMRARVYLLGNSREGAVHIIVYITNGRAIDSDKALKEAKKARAKGIMLFTIGVGSEVDANELGKLATGNNGRFVFTGTSYDDLNPHQQHIAKQICIATPTETQSSQICMRPTDLVFAMDSPFSSGRRPFQQPLKFADGLRTFFHESPSTTNVATISHKVERHDIIRQARTYLLQQPRVEAVRIIVYITNGRATDPEEALKEARKAWDKGILLFVIGVGNKVDVTELGQLATENSGQFVFQAPNYNVLNRLQDQIAEEICSAKPLVTQSDQTCMQPTEMVFVMHMPVSSGGQPYQQESNFVHGLLKYFHQSPFTTIAAVTTSTNGSHEIIRDARTYLLQRPRVEAARIIVYITNGRATDPEETLKEANEVRAKGILLFALGVGYDVGVTELGQLATENNEQFVFVASDFNDLNRRQRAIAEQICSASVVKPPVEDCHRRMDIVFLVDTSYSMLATEFPLELEFVQDMIGQFDVSPSATRVAVISYSTGYADIFSLDQYQSSELMIEAVGKIHFTNGRRVDSHDAIQHALDLLLRQPRNGALRVIILISAGMATDRQRTIQVADNVRTKGILLFCVGVGWFLNTEELGHIATQNSKRFVYSADNFDDLRAISKSLVPQICAIPGHDVQSLQCLRPSDVVILVDTSYDISHTDFLLQLKFVQDLITHFDVSPQKTRVAVVSYSQGYREEFSLDQYQSADTMMFAVENIVSTRGGYLDSHDAIQHALKLLIRQSRNDAAHVIIYITHGRATLKDKTLKIADKVRDKGILMFSVGVGREVDTEELKEIATEKTKEFAHSVYSFHDLSTLSQTLGPKVCAAEIPIIERVRCDGPAELVFLVDVSRSIYPLDFPFELEFVNEVIEMFDISTIRVAAVSYSRGVNEEFNLNQHRTVHALRTAVDEITFASGPTTDTHTAIQYARQIILRESSKDVTRIIIAIVEGRPTDGPSTVQEAEEARKEGIILFAVGVGNEVNRRELGKMAFQNTEDFVHTACTFDTLPDISKVVGQKACSVISDASTATNKQ", "length": 1300, "molWeight": 144581, "crc64": "BFCE64296E6429C7", "md5": "EE275349F0D450D251A056BAE3C030C0"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 7}, "uniParcId": "UPI002B2BC525"}, "cluster_size": 1, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UVH2", "uniProtkbId": "A0AAT9UVH2_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41695.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41695.1"}], "value": "Cytochrome P450 3639B3"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 451, "modifier": "EXACT"}, "end": {"value": 451, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41695.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117255", "properties": [{"key": "ProteinId", "value": "WIM41695.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MELSQFFQVLNSNTLWILIFTLIIYYIRLKRNEKNIRREKCASSFDGPTTIPYFGNSLNFILRPEDIANTLIHYTKKYGPRYRLWIGEKLSIVIADAADAETVLTSSKSLNKGQDFCELFGRIFAPSSFSSDGNVWKQERKIFQFPVKPNALVNYIETMNDVARMIVNELRPKARSGENFDAVNYMSRATLYIACASFFDTKEPIISQEHYPIFRETAERFLKDSFDLMFHPKLIRKIKQLVGLQKFKRTFNIMKLPYLKLAQTGALNRKRSPDDGNKAEEYDEPFKKIIDILRDDSFNAKSRFAETATFIVGGSETSAVTLSFTMLMLAIHQDVQDKVYEELEGIFGDSDRDVAAEDIKRMNYLEKVFKETLRMFPLVPFLIRTPKEDIALGDRTIPSGTEFIINVISLQRNSKYFPDPDKFDPERFSEERIKALPKGSYLPFAIGARNCLGKNFAMHEIKILCSAVLRKYRLYSTTKLNDIKIEMAFLLGKVDGYNISISARNKA", "length": 507, "molWeight": 58442, "crc64": "09A1B046AF5048B5", "md5": "E28DF4287A6D6B7CF5CD8186F2A7F897"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D33694"}, "cluster_size": 4, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NPS1", "uniProtkbId": "A0AA96NPS1_9CRUS", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paraplatyarthrus sp", "taxonId": 3079294, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00134.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Peracarida", "Isopoda", "Oniscidea", "Crinocheta", "Paraplatyarthridae", "Paraplatyarthrus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012561"}], "value": "cellulose 1,4-beta-cellobiosidase (non-reducing end)"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012561"}], "value": "3.2.1.91"}]}, "flag": "Fragment"}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.", "ecNumber": "3.2.1.91", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001641"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006044"}], "value": "Belongs to the glycosyl hydrolase 7 (cellulase C) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00134.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 133, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00134.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023277"}], "id": "KW-0119", "category": "Biological process", "name": "Carbohydrate metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023001"}], "id": "KW-0136", "category": "Biological process", "name": "Cellulose degradation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023295"}], "id": "KW-0326", "category": "Molecular function", "name": "Glycosidase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023326"}], "id": "KW-0624", "category": "Biological process", "name": "Polysaccharide degradation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "37780085", "citationType": "journal article", "authors": ["Javidkar M.", "Cooper S.J.B.", "Shokri Bousjein N.", "Humphreys W.F.", "King R.A.", "Austin A.D."], "citationCrossReferences": [{"database": "PubMed", "id": "37780085"}], "title": "Evolution of endoglucanase genes in subterranean and surface isopod crustaceans from Central Western Australia.", "publicationDate": "2023", "journal": "Ecol. Evol.", "firstPage": "0", "lastPage": "0", "volume": "13"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00134.1"}], "value": "NODE_18582", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00134.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-1O3KGA4J1ARN2", "citationType": "submission", "authors": ["Javidkar M."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00134.1"}], "value": "NODE_18582", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00134.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR531533", "properties": [{"key": "ProteinId", "value": "WNU00134.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004553", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity, hydrolyzing O-glycosyl compounds"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0030245", "properties": [{"key": "GoTerm", "value": "P:cellulose catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.70.100.10", "properties": [{"key": "EntryName", "value": "Glycoside hydrolase, family 7, domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR013320", "properties": [{"key": "EntryName", "value": "ConA-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR001722", "properties": [{"key": "EntryName", "value": "Glyco_hydro_7"}]}, {"database": "InterPro", "id": "IPR037019", "properties": [{"key": "EntryName", "value": "Glyco_hydro_7_sf"}]}, {"database": "PANTHER", "id": "PTHR33753", "properties": [{"key": "EntryName", "value": "1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR33753:SF2", "properties": [{"key": "EntryName", "value": "GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00840", "properties": [{"key": "EntryName", "value": "Glyco_hydro_7"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49899", "properties": [{"key": "EntryName", "value": "Concanavalin A-like lectins/glucanases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "TTHPCNVDGYYPCEGTDCGDNGDDRYNGVCDKDGCDYAIYRNGVQDFYGPGMTVNSNSVITIITQFITSDGSDSGSLSEVRRIYVQGGQTIQNAAVNFAGVTAHDSITSAYCSEIKTFFGDYDGHAAKGGLSS", "length": 133, "molWeight": 14126, "crc64": "E5CE21552760A832", "md5": "3F579DB9869FA5B4AD6F5C4035909A9E"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI002B2978B8"}, "cluster_size": 1, "family": "Paraplatyarthridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6S493", "uniProtkbId": "A0AAU6S493_IPSTY", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Ips typographus", "commonName": "European spruce bark beetle", "taxonId": 55986, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZI48997.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Coleoptera", "Polyphaga", "Cucujiformia", "Curculionidae", "Scolytinae", "Ips"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZI48997.1"}], "value": "OR41"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 7, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 45, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 131, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 199, "modifier": "EXACT"}, "end": {"value": 224, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 280, "modifier": "EXACT"}, "end": {"value": 298, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 310, "modifier": "EXACT"}, "end": {"value": 329, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AA48G6LC0QKOV", "citationType": "submission", "authors": ["Biswas T.", "Sims C.", "Yuvaraj J.K.", "Roberts R.E.", "Lofstedt C.", "Andersson M.N."], "title": "Functional characterization supports multiple evolutionary origins of pheromone receptors bark beetles.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZI48997.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR987888", "properties": [{"key": "ProteinId", "value": "WZI48997.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEANKNLNKKLISWIRIIMIITGYWDRPISSIKFINSCLHVYSVGMRASCFLFWIFLTTELIRLIIFDYPEEVIVSSVAIVVTQLRVITRSWTYLKHNTLDIFSQILDGDQEKWVYGEREIEEVYRRKTTFLNIGAAVFIFADAMTVISLDIIGVMGTLRIHSHNLATNDTLESHLMLQLIFPLNNMAHIKAYFLSEMFWSWIGFTQNVGTELIYVTILVYAATKLEILKVKFRSFVQDDFELCSSNDKVQEKTDLLKNLIREHQSVILFITQFNEKVKYITMVEFIFSSLDLASVSMNLSNDVTMEDGWVFFYCLLMVTQLFLIGWNCNEIKIQSENIGIALYQSKWYVLNQEAKQMLLCVITSTKRPLLMTIGPFGPMTTDSCVLILKAAYSYINIMKK", "length": 401, "molWeight": 46509, "crc64": "A736581BE9BE7578", "md5": "AC36DC5A53BD866910AEF6D9B3597797"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 6}, "uniParcId": "UPI0035D38657"}, "cluster_size": 1, "family": "Curculionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN55", "uniProtkbId": "A0AA96MN55_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50070.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50070.1"}], "value": "Group XV phospholipase A2-like protein"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 403, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041673236"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50070.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460147", "properties": [{"key": "ProteinId", "value": "WNS50070.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008374", "properties": [{"key": "GoTerm", "value": "F:O-acyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006629", "properties": [{"key": "GoTerm", "value": "P:lipid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.50.1820", "properties": [{"key": "EntryName", "value": "alpha/beta hydrolase"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR029058", "properties": [{"key": "EntryName", "value": "AB_hydrolase_fold"}]}, {"database": "InterPro", "id": "IPR003386", "properties": [{"key": "EntryName", "value": "LACT/PDAT_acylTrfase"}]}, {"database": "PANTHER", "id": "PTHR11440", "properties": [{"key": "EntryName", "value": "LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02450", "properties": [{"key": "EntryName", "value": "LCAT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53474", "properties": [{"key": "EntryName", "value": "alpha/beta-Hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKFSCLLVTAAAALVSTSLTASSNELKSRVLLVPGLASSRLSASIKTDGAAWCRTHGNHFALVWISLRRIFCSHYLKLVFNPITKTYTNRPGVTVKVPGFGKTNTVECVGSFILCTLLRSLNLMDQMVKFFVRQGYQRGADIRAAPYDWRLAPDSLRAQGYYAKLKGLIETMYNGKKVTIATHSLGSLTTLYFLNSVVTSEWKNKYVKAFVPMGAPWGGAVQTLSGFLYGYIPASNQRIIPRFIMNYSRCIIRTLQSAYFLAPRPDVFGSQVLVRTPTKNYTAQNYQQLYQDIHYPIGWQKHQAALGVIKGYPNPGVPTFCIYGTNVPTPEQLVYNKSGDLLNAIPKIIHGNGDGSVNKESLEICHRWAKKVTVINKVNHSDIVRSSQVMHEILRIATADTIQ", "length": 403, "molWeight": 44881, "crc64": "C7390FE01E57728D", "md5": "B7E34B109311053BCDBFDFF526495D93"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B28B46A"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7B918", "uniProtkbId": "A0AAU7B918_CEREL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Cervus elaphus", "commonName": "Red deer", "taxonId": 9860, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28076.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Laurasiatheria", "Artiodactyla", "Ruminantia", "Pecora", "Cervidae", "Cervinae", "Cervus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28076.1"}], "value": "Transmembrane protein 183A isoform X11"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28076.1"}], "value": "MEM183A"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28076.1"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28076.1"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-E18AOKK6JUCU4", "citationType": "submission", "authors": ["Zheng Q."], "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28076.1"}], "value": "Antler cartilage", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBC28076.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP824820", "properties": [{"key": "ProteinId", "value": "XBC28076.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0019005", "properties": [{"key": "GoTerm", "value": "C:SCF ubiquitin ligase complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0031647", "properties": [{"key": "GoTerm", "value": "P:regulation of protein stability"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR026509", "properties": [{"key": "EntryName", "value": "TMEM183"}]}, {"database": "PANTHER", "id": "PTHR20988", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN 183A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR20988:SF2", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN 183A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MARGPGPLTRPRPDTVVMPKRGKRLKFRAQDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEASQVPAVEALSGAGEPCDIIDSSGETDAQEESIHERTISRKKKSKRHRVLTFLVQKDCWEQTGTNVGIQLQVQKTVPKIKEQVYGRIAASHSVRRCSYQPGPGLLPTAGHHPQFHLYSNCHGNDIYPVYYQREHGHAASSSETGVPRLSCPWWSETAQ", "length": 224, "molWeight": 24664, "crc64": "E82C2605A7B35D3A", "md5": "53B4DFCF2C03DDCD150778C0280BC73E"}, "extraAttributes": {"uniParcId": "UPI0035D2F7D0"}, "cluster_size": 2, "family": "Cervidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA86IWH2", "uniProtkbId": "A0AA86IWH2_AURAU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 9, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Aurelia aurita", "commonName": "Moon jellyfish", "synonyms": ["Medusa aurita"], "taxonId": 6145, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53439.1"}], "lineage": ["Eukaryota", "Metazoa", "Cnidaria", "Scyphozoa", "Semaeostomeae", "Ulmaridae", "Aurelia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011902"}], "value": "receptor protein-tyrosine kinase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011902"}], "value": "2.7.10.1"}]}, "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53439.1"}], "value": "FGFR"}}], "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:10596"}, {"database": "Rhea", "id": "RHEA-COMP:10136"}, {"database": "Rhea", "id": "RHEA-COMP:20101"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:46858"}, {"database": "ChEBI", "id": "CHEBI:61978"}, {"database": "ChEBI", "id": "CHEBI:456216"}], "ecNumber": "2.7.10.1", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00051243"}]}}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004308"}], "value": "Endomembrane system", "id": "SL-0147"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 198, "modifier": "EXACT"}, "end": {"value": 221, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 303, "modifier": "EXACT"}, "end": {"value": 540, "modifier": "EXACT"}}, "description": "Protein kinase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50011"}]}, {"type": "Active site", "location": {"start": {"value": 440, "modifier": "EXACT"}, "end": {"value": 440, "modifier": "EXACT"}}, "description": "Proton acceptor", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-1"}]}, {"type": "Binding site", "location": {"start": {"value": 310, "modifier": "EXACT"}, "end": {"value": 317, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-2"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 337, "modifier": "EXACT"}, "end": {"value": 337, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-2"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 444, "modifier": "EXACT"}, "end": {"value": 444, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-2"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 445, "modifier": "EXACT"}, "end": {"value": 445, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-3"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420"}}, {"type": "Binding site", "location": {"start": {"value": 458, "modifier": "EXACT"}, "end": {"value": 458, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-3"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420"}}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53439.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-2"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022777"}], "id": "KW-0418", "category": "Molecular function", "name": "Kinase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-3"}], "id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-3"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000615-2"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53439.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023137"}], "id": "KW-0829", "category": "Molecular function", "name": "Tyrosine-protein kinase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B2HUVLRISDPSM", "citationType": "submission", "authors": ["Nakanishi T.", "Sarper S.E."], "title": "Tetraradial symmetry disturbance and recovery at feeding-dependent tentacle initiations in Aurelia aurita polyps.", "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53439.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC778154", "properties": [{"key": "ProteinId", "value": "BES53439.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "SMR", "id": "A0AA86IWH2", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0012505", "properties": [{"key": "GoTerm", "value": "C:endomembrane system"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043235", "properties": [{"key": "GoTerm", "value": "C:receptor complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004714", "properties": [{"key": "GoTerm", "value": "F:transmembrane receptor protein tyrosine kinase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0048468", "properties": [{"key": "GoTerm", "value": "P:cell development"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0007169", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor protein tyrosine kinase signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030182", "properties": [{"key": "GoTerm", "value": "P:neuron differentiation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0050793", "properties": [{"key": "GoTerm", "value": "P:regulation of developmental process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "1.10.510.10:FF:001512", "properties": [{"key": "EntryName", "value": "Receptor tyrosine-protein kinase erbB-2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.30.200.20", "properties": [{"key": "EntryName", "value": "Phosphorylase Kinase, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.510.10", "properties": [{"key": "EntryName", "value": "Transferase(Phosphotransferase) domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR011009", "properties": [{"key": "EntryName", "value": "Kinase-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR000719", "properties": [{"key": "EntryName", "value": "Prot_kinase_dom"}]}, {"database": "InterPro", "id": "IPR017441", "properties": [{"key": "EntryName", "value": "Protein_kinase_ATP_BS"}]}, {"database": "InterPro", "id": "IPR050122", "properties": [{"key": "EntryName", "value": "RTK"}]}, {"database": "InterPro", "id": "IPR001245", "properties": [{"key": "EntryName", "value": "Ser-Thr/Tyr_kinase_cat_dom"}]}, {"database": "InterPro", "id": "IPR008266", "properties": [{"key": "EntryName", "value": "Tyr_kinase_AS"}]}, {"database": "InterPro", "id": "IPR020635", "properties": [{"key": "EntryName", "value": "Tyr_kinase_cat_dom"}]}, {"database": "PANTHER", "id": "PTHR24416:SF550", "properties": [{"key": "EntryName", "value": "FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24416", "properties": [{"key": "EntryName", "value": "TYROSINE-PROTEIN KINASE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07714", "properties": [{"key": "EntryName", "value": "PK_Tyr_Ser-Thr"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF000615", "properties": [{"key": "EntryName", "value": "TyrPK_CSF1-R"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PRINTS", "id": "PR00109", "properties": [{"key": "EntryName", "value": "TYRKINASE"}]}, {"database": "SMART", "id": "SM00219", "properties": [{"key": "EntryName", "value": "TyrKc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF56112", "properties": [{"key": "EntryName", "value": "Protein kinase-like (PK-like)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00107", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_ATP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50011", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00109", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_TYR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "KDDFNSERDKRRISRNGQRLVLLRVHPSDKGKYECKVTDGKTTINRTITVQPEEVVRASPYILQPTDNAVFWAHIGQNMTIECVAFAAGNIHFQLLKVKENRSANGSNSPLEVLKKPTEFISEGKSTHTAQTYRAIFHFINITKKDFFIYTCMAGNSVGFSATSFRIKEKRRSSTKAPVATIPLTRPPQKKGMSGSTLAAVIGSVLILVTLIVLGALFRFCSKRSKRHHSRQEVSHNTIKESVSMQPQGATSTVMNHFGSLTRQRTLNRNISVKSRLSSTLTEQYFFADIVYDPEWEIRFDSLEFQSVLGEGAFGRVMKGIANGIPGRPIPTTVAIKMLKEDATDHELSDLISEMEVMKMIGKHTNIINLLGVCTQGELCVIVEYCRYGNLRQYLRERRPTTPPLPEPPEKITLLDLASYAYQVSKGMEYLASKKCIHRDLAARNVLVNEEKVLKIADFGLARDIHAEDYYRKRTDGRLPVKWMALEALFDRVYTIQSDVWAFGVLVWEIITFGGTPYPGVPLERLFRSTKKWLSHGKTN", "length": 540, "molWeight": 61068, "crc64": "2D50BDBD6DEF5987", "md5": "AEEABF0CBFC835C0C14EEA734501B563"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1, "Active site": 1, "Binding site": 5, "Non-terminal residue": 1}, "uniParcId": "UPI002B285421"}, "cluster_size": 1, "family": "Ulmaridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7YFX0", "uniProtkbId": "A0AAU7YFX0_NIDPL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Nidirana pleuraden", "commonName": "Yunnan pond frog", "synonyms": ["Babina pleuraden"], "taxonId": 369511, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87684.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Ranoidea", "Ranidae", "Nidirana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87684.1"}], "value": "Amplexin 10"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 101, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043481969"}, {"type": "Non-terminal residue", "location": {"start": {"value": 101, "modifier": "EXACT"}, "end": {"value": 101, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87684.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "38891597", "citationType": "journal article", "authors": ["Zheng P.", "Gong Y.", "Wang B.", "Yu H.", "Huang S.", "Liao X.", "Jiang J.", "Ran J.", "Xie F."], "citationCrossReferences": [{"database": "PubMed", "id": "38891597"}], "title": "Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.", "publicationDate": "2024", "journal": "Animals (Basel)", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87684.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-E24AGF4876IHP", "citationType": "submission", "authors": ["Zheng P."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87684.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP623145", "properties": [{"key": "ProteinId", "value": "XBY87684.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR045860", "properties": [{"key": "EntryName", "value": "Snake_toxin-like_sf"}]}, {"database": "SUPFAM", "id": "SSF57302", "properties": [{"key": "EntryName", "value": "Snake toxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKAVITLLILGLLFIHGEGLKCWNIRSIGSYNILSVKNCAENEDRCIARGPTIDLQTWDTYDCATQAECQREDKLTKVLKCCCEDQCNNGKMDEGGAPEEM", "length": 101, "molWeight": 11289, "crc64": "75D29ED4D0F64F9C", "md5": "14557904A51F8620D2CF5494E9BDDE0F"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D32823"}, "cluster_size": 1, "family": "Ranidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA95Z9E3", "uniProtkbId": "A0AA95Z9E3_9CUCU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Anthonomus eugenii", "commonName": "pepper weevil", "taxonId": 122869, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96190.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Coleoptera", "Polyphaga", "Cucujiformia", "Curculionidae", "Curculioninae", "Anthonomini", "Anthonomus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96190.1"}], "value": "Odorant binding protein C03"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96190.1"}], "value": "OBPC03"}}], "features": [{"type": "Region", "location": {"start": {"value": 102, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DHPI8O2N9J4MB", "citationType": "submission", "authors": ["Segura Leon O.L.", "Lechuga-Paredes P.", "Cibrian Tovar J.", "Torres Huerta B."], "publicationDate": "JUL-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96190.1"}]}, {"referenceNumber": 2, "citation": {"id": "36834814", "citationType": "journal article", "authors": ["Lechuga-Paredes P.", "Segura-Leon O.L.", "Cibrian-Tovar J.", "Torres-Huerta B.", "Velazquez-Gonzalez J.C.", "Cruz-Jaramillo J.L."], "citationCrossReferences": [{"database": "PubMed", "id": "36834814"}], "title": "Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.", "publicationDate": "2023", "journal": "Int. J. Mol. Sci.", "firstPage": "0", "lastPage": "0", "volume": "24"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96190.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP056779", "properties": [{"key": "ProteinId", "value": "WNH96190.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNLPSRTSSKITKKPTPLLTSMNMSNVCANFHEHVKCVSKGLNLIQEDGKINPEGVKTHIGHIVSDQAKADSIFKECAQDKGSERENTKHLWECLYEKHVFGSSHGHHHSSESSSSSEEHHHH", "length": 123, "molWeight": 13761, "crc64": "9A5CF5209400D366", "md5": "61330C2D8766453FE5983FE01CE60240"}, "extraAttributes": {"countByFeatureType": {"Region": 1}, "uniParcId": "UPI002B2BDFD2"}, "cluster_size": 1, "family": "Curculionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLI9", "uniProtkbId": "A0AAU0QLI9_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56488.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56488.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 9, "modifier": "EXACT"}, "end": {"value": 30, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 57, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 127, "modifier": "EXACT"}, "end": {"value": 127, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56488.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56488.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56488.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56488.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970381", "properties": [{"key": "ProteinId", "value": "WPO56488.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQSQSMWRLYLFFLMCVLSTCVEWVTVPLFESGPRIFPFKIWMPVDPANSPDYYIGYVYQTVAIFLSGTIFITVDFITISMINFASAQLDIIEEKINQTRRIPLGIDKKERENRLKFNNDTLNECIR", "length": 127, "molWeight": 14917, "crc64": "282AF6DA040141FB", "md5": "1646F7C5AC1DD72F40FD5DFF4C7099C8"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 1}, "uniParcId": "UPI0030897CC4"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBK1", "uniProtkbId": "A0AAU6PBK1_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Protohermes xanthodes", "taxonId": 1452977, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59960.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Megaloptera", "Corydalidae", "Corydalinae", "Protohermes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59960.1"}], "value": "Nicotinic acetylcholine receptor beta2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 584, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043627070"}, {"type": "Transmembrane", "location": {"start": {"value": 418, "modifier": "EXACT"}, "end": {"value": 441, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 448, "modifier": "EXACT"}, "end": {"value": 466, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 486, "modifier": "EXACT"}, "end": {"value": 504, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 557, "modifier": "EXACT"}, "end": {"value": 582, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 178, "modifier": "EXACT"}}, "description": "Farnesoic acid O-methyl transferase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF12248"}]}, {"type": "Domain", "location": {"start": {"value": 203, "modifier": "EXACT"}, "end": {"value": 415, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel ligand-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02931"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59960.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38879304", "citationType": "journal article", "authors": ["Yang J.", "Wen X.", "Zou J.", "Huang X.", "Wu T.", "Huang X."], "citationCrossReferences": [{"database": "PubMed", "id": "38879304"}], "title": "De novo transcriptome analysis of Protohermes xanthodes Navas (Megaloptera: Corydalidae) reveling the effects of sublethal chlorpyrifos on the expression of cholinergic neuronal genes.", "publicationDate": "2024", "journal": "Pestic. Biochem. Physiol.", "firstPage": "0", "lastPage": "0", "volume": "202"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59960.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-CQT4T7LJ8MPGH", "citationType": "submission", "authors": ["Huang X."], "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH59960.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP239126", "properties": [{"key": "ProteinId", "value": "WXH59960.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005230", "properties": [{"key": "GoTerm", "value": "F:extracellular ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd18989", "properties": [{"key": "EntryName", "value": "LGIC_ECD_cation"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.70.170.10", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel ligand-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.390", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR022041", "properties": [{"key": "EntryName", "value": "Methyltransf_FA"}]}, {"database": "InterPro", "id": "IPR006202", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd"}]}, {"database": "InterPro", "id": "IPR036734", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd_sf"}]}, {"database": "InterPro", "id": "IPR036719", "properties": [{"key": "EntryName", "value": "Neuro-gated_channel_TM_sf"}]}, {"database": "InterPro", "id": "IPR038050", "properties": [{"key": "EntryName", "value": "Neuro_actylchol_rec"}]}, {"database": "PANTHER", "id": "PTHR36695", "properties": [{"key": "EntryName", "value": "AGAP008648-PA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR36695:SF12", "properties": [{"key": "EntryName", "value": "AGAP008648-PA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF12248", "properties": [{"key": "EntryName", "value": "Methyltransf_FA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02931", "properties": [{"key": "EntryName", "value": "Neur_chan_LBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF90112", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane pore"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63712", "properties": [{"key": "EntryName", "value": "Nicotinic receptor ligand binding domain-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEYLILLLFTCVLITTDAIKNTTKSDFSTCKEYISKGYVYKQYYEIKNLFHSAGYIVDLHFSVQSSHDAHILLTPATDLDKKEPVYEIVLGAGRNTFSDLRRLRGKGTKGTSRTAGLLSIFEMRSFWLHISTEGLIEVGREGEDLAFLSWKDVSPLPVRFLSFSSWPGVEAKWLFDCKPINKSTEQMSESYLNQVEKPLTQIEQLRKQLLTNYDPYIVPETDGLTYVFLAFTCEHVHFDEKKSLLSISGKFDLQWQDEKMVWNSSEFDDITSLVLSHREIWMPTDLFLFNSADTGGDILQASSMKIEQSGYASWSPKTNMKIWCLTKNIKYWPYNDYDCELSLGFWTQQNLIRLFPASRAKLSTHIVSSGWDITHFTTGNTALDLPWIKEQSIDYSDEVDNYTTAITIYMKLTRRRSLYTVICFSIQFITSFLLLLIFCVSPTGNLKITLSCLIIVLLTGSLLALTKHAPSHPIYVPGLINTCQQMIIATAVALTISIIVICLSRNSCNKPLPSVVCNILSHHSIQTILLLPKSKGCNDYGKLNSSSEKTAEIQEMWIALGTAIDRLFFIIYTIFISILFSIHY", "length": 584, "molWeight": 66501, "crc64": "85792E86CE6C3A10", "md5": "5C9B43FE24401101164974DADDFED253"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 4, "Domain": 2}, "uniParcId": "UPI0035D2924F"}, "cluster_size": 1, "family": "Corydalidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NQJ0", "uniProtkbId": "A0AA96NQJ0_PORPN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Porcellionides pruinosus", "commonName": "Woodlouse", "taxonId": 96870, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00133.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Peracarida", "Isopoda", "Oniscidea", "Crinocheta", "Porcellionidae", "Porcellionides"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012601"}], "value": "cellulase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012601"}], "value": "3.2.1.4"}]}, "flag": "Fragment"}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.", "ecNumber": "3.2.1.4", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00000966"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007072"}], "value": "Belongs to the glycosyl hydrolase 9 (cellulase E) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 15, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "cellulase", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041679496"}, {"type": "Domain", "location": {"start": {"value": 7, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "Glycoside hydrolase family 9", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00759"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00133.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 100, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00133.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023277"}], "id": "KW-0119", "category": "Biological process", "name": "Carbohydrate metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023001"}], "id": "KW-0136", "category": "Biological process", "name": "Cellulose degradation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023295"}], "id": "KW-0326", "category": "Molecular function", "name": "Glycosidase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023326"}], "id": "KW-0624", "category": "Biological process", "name": "Polysaccharide degradation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "37780085", "citationType": "journal article", "authors": ["Javidkar M.", "Cooper S.J.B.", "Shokri Bousjein N.", "Humphreys W.F.", "King R.A.", "Austin A.D."], "citationCrossReferences": [{"database": "PubMed", "id": "37780085"}], "title": "Evolution of endoglucanase genes in subterranean and surface isopod crustaceans from Central Western Australia.", "publicationDate": "2023", "journal": "Ecol. Evol.", "firstPage": "0", "lastPage": "0", "volume": "13"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00133.1"}], "value": "NODE_23006", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00133.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-1O3KGA4J1ARN2", "citationType": "submission", "authors": ["Javidkar M."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00133.1"}], "value": "NODE_23006", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00133.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR531534", "properties": [{"key": "ProteinId", "value": "WNU00133.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004553", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity, hydrolyzing O-glycosyl compounds"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0030245", "properties": [{"key": "GoTerm", "value": "P:cellulose catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.50.10.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008928", "properties": [{"key": "EntryName", "value": "6-hairpin_glycosidase_sf"}]}, {"database": "InterPro", "id": "IPR012341", "properties": [{"key": "EntryName", "value": "6hp_glycosidase-like_sf"}]}, {"database": "InterPro", "id": "IPR001701", "properties": [{"key": "EntryName", "value": "Glyco_hydro_9"}]}, {"database": "PANTHER", "id": "PTHR22298", "properties": [{"key": "EntryName", "value": "ENDO-1,4-BETA-GLUCANASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00759", "properties": [{"key": "EntryName", "value": "Glyco_hydro_9"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48208", "properties": [{"key": "EntryName", "value": "Six-hairpin glycosidases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "FFCFLFCHALVFYEANRSGYLPSDQRVEWRGDSALTDGSDNSVDLEGGYYDAGDLVKFGLPLGYTVTFLSWGLITYEEGYIQAGQISYAETTIRWATDFI", "length": 100, "molWeight": 11294, "crc64": "CE4BF4A6AD880A73", "md5": "4E33268AD1D5DE72D73FEF388FCFE8F6"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2A6C69"}, "cluster_size": 1, "family": "Porcellionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P2T3", "uniProtkbId": "A0AAU7P2T3_CALMC", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Callistoctopus minor", "commonName": "Octopus", "synonyms": ["Octopus minor"], "taxonId": 515824, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35920.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Cephalopoda", "Coleoidea", "Octopodiformes", "Octopoda", "Incirrata", "Octopodidae", "Callistoctopus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35920.1"}], "value": "Histidine decarboxylase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35920.1"}], "value": "HDC"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "pyridoxal 5'-phosphate", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001933"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000382"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:597326"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000382"}], "value": "Belongs to the group II decarboxylase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 376, "modifier": "EXACT"}, "end": {"value": 412, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 381, "modifier": "EXACT"}, "end": {"value": 406, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022793"}], "id": "KW-0210", "category": "Molecular function", "name": "Decarboxylase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023239"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000382"}], "id": "KW-0456", "category": "Molecular function", "name": "Lyase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022898"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000382"}], "id": "KW-0663", "category": "Ligand", "name": "Pyridoxal phosphate"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B1PARK2TANKH3", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35920.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP889621", "properties": [{"key": "ProteinId", "value": "XBS35920.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016831", "properties": [{"key": "GoTerm", "value": "F:carboxy-lyase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0030170", "properties": [{"key": "GoTerm", "value": "F:pyridoxal phosphate binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0019752", "properties": [{"key": "GoTerm", "value": "P:carboxylic acid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.90.1150.10", "properties": [{"key": "EntryName", "value": "Aspartate Aminotransferase, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.640.10", "properties": [{"key": "EntryName", "value": "Type I PLP-dependent aspartate aminotransferase-like (Major domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002129", "properties": [{"key": "EntryName", "value": "PyrdxlP-dep_de-COase"}]}, {"database": "InterPro", "id": "IPR015424", "properties": [{"key": "EntryName", "value": "PyrdxlP-dep_Trfase"}]}, {"database": "InterPro", "id": "IPR015421", "properties": [{"key": "EntryName", "value": "PyrdxlP-dep_Trfase_major"}]}, {"database": "InterPro", "id": "IPR015422", "properties": [{"key": "EntryName", "value": "PyrdxlP-dep_Trfase_small"}]}, {"database": "PANTHER", "id": "PTHR11999:SF167", "properties": [{"key": "EntryName", "value": "AROMATIC-L-AMINO-ACID DECARBOXYLASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11999", "properties": [{"key": "EntryName", "value": "GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00282", "properties": [{"key": "EntryName", "value": "Pyridoxal_deC"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF53383", "properties": [{"key": "EntryName", "value": "PLP-dependent transferases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTTRQIGNDRLCKRSLQSWGFYVAVKSIPGTASEATFVALLAARTEAIRRYKLLHGSMDDSDINGRLVAYCSDQVCGTLGTTGACAFDNLTELGAYRKFMVGIEHAHSMAFNPSKWMMVNFECTAMIKDSTSLHRTFNVDPLYLKHENSGAAIDYMHWQIPLSKRFRALKLWFVIRSFGVEGLQKHIRHGKYVIRFTVTSQYCTEEDIRGDLKTIQDTASVVLRDLSLLMNKTKEDEVIREIPEIPEEKAIITSSEETKLERSLSMKRRDFGMSLILSHVPCSPKFINGSFAAIFDNNETILEFARHLTSSDINGRPIRLSPRRGVKLREQAKQHSLDFSTMIPGRRMSTGTARFKQGSLDTKVDDILDSTPDNYYTNGFDEIHGKKNDKEEGKENDKDEVQKQQELDAQNQQNQQLQVVQLQQNQLHSVLAASQEKASSFLDKIKKLTPKRLTGDTAANNNVKISNGLHVCPHCGKSIV", "length": 480, "molWeight": 54214, "crc64": "88886980B32C0940", "md5": "5CBC6074B03B963436CD8CF14C94400C"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D2704A"}, "cluster_size": 1, "family": "Octopodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1D4", "uniProtkbId": "A0AAU7P1D4_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30735.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30735.1"}], "value": "Low density lipoprotein receptor"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30735.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 128, "modifier": "EXACT"}, "end": {"value": 128, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30735.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30735.1"}], "id": "KW-0449", "category": "PTM", "name": "Lipoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30735.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30735.1"}], "value": "11", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30735.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892391", "properties": [{"key": "ProteinId", "value": "XBS30735.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "VDGSLCVMKPLCTQDRLHLPAAWGAGAGLSFSSSPGTGKCSGWCHVYTFCHSALISSCKGHSPPRSVGAASTGTYRSHTWVLIWHLPLAMLRFLPPDMGIKLVVSKLGFLVGSRSGFLKLHLEAGTGG", "length": 128, "molWeight": 13494, "crc64": "F8252C5274587628", "md5": "20183AA72EEB855A6981F70E25FAF580"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D32AEE"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7B3", "uniProtkbId": "A0AAN0N7B3_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34105.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34105.1"}], "value": "Tachykinin-like peptide receptor 99D"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 694, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042861680"}, {"type": "Transmembrane", "location": {"start": {"value": 98, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 138, "modifier": "EXACT"}, "end": {"value": 157, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 169, "modifier": "EXACT"}, "end": {"value": 197, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 218, "modifier": "EXACT"}, "end": {"value": 242, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 355, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 628, "modifier": "EXACT"}, "end": {"value": 646, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 666, "modifier": "EXACT"}, "end": {"value": 690, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 118, "modifier": "EXACT"}, "end": {"value": 687, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34105.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155031", "properties": [{"key": "ProteinId", "value": "WRW34105.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004983", "properties": [{"key": "GoTerm", "value": "F:neuropeptide Y receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR000611", "properties": [{"key": "EntryName", "value": "NPY_rcpt"}]}, {"database": "PANTHER", "id": "PTHR45695:SF9", "properties": [{"key": "EntryName", "value": "LEUCOKININ RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45695", "properties": [{"key": "EntryName", "value": "LEUCOKININ RECEPTOR-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "PRINTS", "id": "PR01012", "properties": [{"key": "EntryName", "value": "NRPEPTIDEYR"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTIILIYIFLVFQFNKTLSLKSLTSHTDQFPSKNRENLNENILILNKFETHSLINDNQLSLLNDTYQFEKNYNLNKLINFTENESEKQNLNTLYDVPVYLILILAFAYGLVSLTAVLGNSIVLWFVVRSKKLRTVTNIFIANLAIADILIGALAIPFQFQAALLQRWVLPHFFCSFCSFIQIVSVNVSIFTLSAIAADRYLVVFYPINYRITKKVAKIIVFFIWFFAILAAIPSLIALKVVYVPDLRNISLNQQSTNAFIQAINYLNKNYTDSFGLTELQKTLNVSSSFENSLNNSALSIEHPNSKTIFLIDDFLAKIDLTQNKDDKLGLFQNNFTLPTKAHCGNVGLSTYYWKMYNLFLVLIQYFIPLIVITFAYSRMGLKLKLVEEPIEKRNSAKNLKRINTNSSGGFSISSFRTNNNLNYSPCNANLNFKNAFELKEKDNIFINQNDKKSKLKKLSNSNPCSPLEENKIFKRNSSLNKPQSNLNINKSLIKKHPLCIDNEIIMNNNNDLLKNNNVDKLNSSCLKKICKCNIEENVIKEEIDEDFNENIKKENQKHSHHYQNQLNSKNQQFIQLEDYKKNIIQHESRLKQTGSVHSSLMMPIISKSISSLRDNPQAEYIVINKKKVVKMLFIVVALFAFCWLPLQTYNLLEDIFVDINKYRYINLIWFVFHWLAMSNSSVNPFIYAIYTLRN", "length": 694, "molWeight": 80237, "crc64": "721CFF90FC169CDB", "md5": "77421B4C79DA8F57EE6965FCC685B44A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI00324A506E"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZER9", "uniProtkbId": "A0AB38ZER9_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02773.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02773.1"}], "value": "Venom cystatin 9"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 125, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044200308"}, {"type": "Domain", "location": {"start": {"value": 38, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "Cystatin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00043"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02773.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517523", "properties": [{"key": "ProteinId", "value": "WXI02773.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004869", "properties": [{"key": "GoTerm", "value": "F:cysteine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00042", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.450.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000010", "properties": [{"key": "EntryName", "value": "Cystatin_dom"}]}, {"database": "InterPro", "id": "IPR046350", "properties": [{"key": "EntryName", "value": "Cystatin_sf"}]}, {"database": "SMART", "id": "SM00043", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54403", "properties": [{"key": "EntryName", "value": "Cystatin/monellin"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFKSFSIAIVLVLAGSLLQNYGEAAKIPKPLRTKSAKLCLGCAREISTDDKELNKGLNVLMQLENANLSNLKILKATVQTVAGYKYKTEFEADLDGKKKLCKSTFIVKPWEKIKRLRVKGSIICN", "length": 125, "molWeight": 13906, "crc64": "6BC064D1CE92AA8C", "md5": "0927BA43F59F4C2C1B2C271B1D2FA336"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388BEC8F"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU31", "uniProtkbId": "A0AAT9UU31_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41637.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41637.1"}], "value": "Cytochrome P450 6PZ28"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41637.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117197", "properties": [{"key": "ProteinId", "value": "WIM41637.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000182", "properties": [{"key": "EntryName", "value": "Cytochrome P450 3A4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002402", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-II"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00464", "properties": [{"key": "EntryName", "value": "EP450II"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYVCAFLTCSIVLLCIHFHNVFGRLCLYFERHGIPYVKPLPLFGNALDWILMKKPLPMIHYDLYRQLEPHRFGGMFFGWKKQILIRDLDLIQNILVKDFCHFQNRNTRPTSPSNILDKQLFLLQDEEWKNLRSKLTNTFTSGKMKIMFPLVRDCGMKLHKVMENLTDEDIRIKEICARYGTDVIGSCAFGLEINSLENPDSIFRQMGKRALEVGYVTLASTREKYPILRFIGFSFLDILRIVFPKLDFFTKLFRNKKYLQDFFFNLVKDTVRHREDHNIVRGDFLDLLIELKHNTHKDFEGNSKLHVEMTDELMTAQCFIFFIAGFETSSSTLNFMLMELAQNHHIQNKLRDEIITVLENNNNELTYEAMKQMKYMDMVIDGNYLRRPPLLPHLCSAF", "length": 398, "molWeight": 46986, "crc64": "31A971F5C3B2C9CC", "md5": "6A854BC23105BA7689A29319B761F663"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "uniParcId": "UPI0035D36D7D"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAX2BJW0", "uniProtkbId": "A0AAX2BJW0_CITAM", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Citrobacter amalonaticus", "taxonId": 35703, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "SAZ64485.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000245995"}], "lineage": ["Bacteria", "Pseudomonadati", "Pseudomonadota", "Gammaproteobacteria", "Enterobacterales", "Enterobacteriaceae", "Citrobacter"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "value": "Leader peptide SpeFL"}}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "value": "Arrest peptide SpeFL"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "value": "speFL"}, "orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "SAZ64485.1"}], "value": "CITRO92_2735"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "value": "A small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (usually speF and potE) by transcriptional and translational attenuation"}], "commentType": "FUNCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "value": "Binds ornithine in stalled 70S ribosomes, blocking the upper two-thirds of the exit tunnel. Contacts 23S rRNA and ribosomal proteins L4 and L22"}], "commentType": "SUBUNIT"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "value": "Induced by ornithine, repressed by putrescine. Part of the speFL-speF-potE operon"}], "commentType": "INDUCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "value": "Belongs to the speF operon leader peptide family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Motif", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 42, "modifier": "EXACT"}}, "description": "Ornithine recognition loop", "evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}]}, {"type": "Binding site", "location": {"start": {"value": 39, "modifier": "EXACT"}, "end": {"value": 39, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:46911"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "ligand": {"name": "L-ornithine", "id": "ChEBI:CHEBI:46911"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "id": "KW-0428", "category": "Molecular function", "name": "Leader peptide"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "id": "KW-0699", "category": "Molecular function", "name": "rRNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_00851"}], "id": "KW-0810", "category": "Biological process", "name": "Translation regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BJKJVJ1IMN8JU", "citationType": "submission", "authors": ["Regsiter A.", "William W."], "publicationDate": "APR-2016", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "SAZ64485.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000245995"}], "value": "92", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "SAZ64485.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000245995"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LT556085", "properties": [{"key": "ProteinId", "value": "SAZ64485.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP000245995", "properties": [{"key": "Component", "value": "Chromosome CITRO92"}]}, {"database": "GO", "id": "GO:0019843", "properties": [{"key": "GoTerm", "value": "F:rRNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006448", "properties": [{"key": "GoTerm", "value": "P:regulation of translational elongation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0031556", "properties": [{"key": "GoTerm", "value": "P:transcriptional attenuation by ribosome"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "HAMAP", "id": "MF_00851", "properties": [{"key": "EntryName", "value": "Leader_SpeFL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR021237", "properties": [{"key": "EntryName", "value": "SpeFL"}]}], "sequence": {"value": "MISFTDQAVFLDKIPSPSTDKEKVIKMENNSRTMPHIRRTTHIMMFAHRNSFDFHLLVFRLWALQHTGLPDSLYRRLTPVFLSAHSA", "length": 87, "molWeight": 10198, "crc64": "7647A8FC581B8EA6", "md5": "0A4CA4BC044CF08BFAE07E11655B651D"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBUNIT": 1, "INDUCTION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Motif": 1, "Binding site": 1}, "uniParcId": "UPI000B5DE629"}, "cluster_size": 1, "family": "Enterobacteriaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LPL5", "uniProtkbId": "A0AAN0LPL5_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34071.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34071.1"}], "value": "Metabotropic glutamate receptor-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 28, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 1109, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042964595"}, {"type": "Transmembrane", "location": {"start": {"value": 665, "modifier": "EXACT"}, "end": {"value": 689, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 701, "modifier": "EXACT"}, "end": {"value": 721, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 733, "modifier": "EXACT"}, "end": {"value": 751, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 805, "modifier": "EXACT"}, "end": {"value": 826, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 858, "modifier": "EXACT"}, "end": {"value": 879, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 891, "modifier": "EXACT"}, "end": {"value": 909, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 921, "modifier": "EXACT"}, "end": {"value": 944, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 701, "modifier": "EXACT"}, "end": {"value": 946, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 3 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50259"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34071.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34071.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154997", "properties": [{"key": "ProteinId", "value": "WRW34071.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000337", "properties": [{"key": "EntryName", "value": "GPCR_3"}]}, {"database": "InterPro", "id": "IPR017978", "properties": [{"key": "EntryName", "value": "GPCR_3_C"}]}, {"database": "InterPro", "id": "IPR050726", "properties": [{"key": "EntryName", "value": "mGluR"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "PANTHER", "id": "PTHR24060", "properties": [{"key": "EntryName", "value": "METABOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00003", "properties": [{"key": "EntryName", "value": "7tm_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00248", "properties": [{"key": "EntryName", "value": "GPCRMGR"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50259", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F3_4"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSKSNHSSNRPLFAVLIFILIDLSVVKSQRAFLNKKSHNTILNEHHLDNDHLSVRKNPYNDLEKLEPLWYEETEFDEQNSNLHDTLFKNVLHATQLNSGLTIIPTIERSNLNNQYHLQNFYLTALLPIHKKKLNYNLTEICSEEINSPAIYDLEAILWTLDQINLLIANKNGLNFNLAVLDTCSSPNILSKLLNNLLSETPKHLKDEEYEIPLPFFSSDNLISFVSSVSPPEFKVAHDLLSPFNVSLISAQDISFLNQKLGFSKNVIQTALPLEYFTLAALQHLKNQKKKKFSVLYSNSSMQSSMMLDTLVKWITLENKKSKKLIDTKELDKKQNFCMQSVINVPSDKKLSTGEASQILIQLQNENKNIENSADDNIVLVLTESHTTRELLIAYKHLLNAGILKQLSFILIKESNLNIVSGIESSMINMLVLRESQKSLKDFVEYFEQLKPENNLRNPFFKQYWLQSVNCGQNRDCLFDQIDPINTVNIIQSTFALSKAFLKLKNEICAQKDKLEAGENFEAICNSFNESLVKSEEKKTNSHNYIKTHLLSQLVKDELELSQLSKHFNHIIKFTEHAFPEKSVDVLKFRIVNQAYRFDRVANYLNGDIVEQLKNIDSKTFSVNYKLLTCHQTYSYQSSSLKIDQKNSLKKIIPITFWSKSWWWHWWWRIAAIVNLIGALSVFVCALYFLFTFDYNVGTTILGYMILFGIFLLYIVNFFFIFPFNFVVCWVRCYLMSISYSTILSAMLVKVMNNWRIHTYNNYNDLYIQHLNIVGGNNIINNNENIFQNQNSNNFLNKKLNSLSTLMSMCLGLISLGMLSNLVWLIIYPPRAQQLIIENIQQWKCYNTQFAVLIETDSIFSILFSVMLILITMFFSVLTWKYSTINSYESRWIMFSCYVIVVTWIIWAFLFKMFHLVELRDLFVVIANLLVSTSILICMFLRKLIIFYKLKKSKKQNKTHQNLVNSTTSSFSTYYGSVTKSKSQSIINKNNSQNDQDNFDNVSTISAITTTSSIISSVKNYFTKKNSFDYNNETDFHLSSISDQSIATKNKTNKQQVITNELYPMDVYEAGSRQSNEQTSQQPDSLFFTEKKNIFSSNHSLYLIEEKDYI", "length": 1109, "molWeight": 128516, "crc64": "2B276AD2D2911EA6", "md5": "2BEB7B5838B2558EC4DF3C263330770D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI00324C77B4"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7NKJ7", "uniProtkbId": "A0AAU7NKJ7_9FABA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Saraca asoca", "taxonId": 1073321, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96860.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Fabales", "Fabaceae", "Detarioideae", "Saraceae", "Saraca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96860.1"}], "value": "Anthocyanidin reductase"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96860.1"}], "value": "ANR"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023445"}], "value": "Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 65, "modifier": "EXACT"}, "end": {"value": 65, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96860.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023241"}], "id": "KW-0284", "category": "Biological process", "name": "Flavonoid biosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022857"}], "id": "KW-0521", "category": "Ligand", "name": "NADP"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-E4U7KMIOLH7AI", "citationType": "submission", "authors": ["Himaja K.", "Veerapandiyan K.", "Usha B."], "title": "Transcriptome analysis of Saraca asoca.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96860.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP905502", "properties": [{"key": "ProteinId", "value": "XBR96860.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0033729", "properties": [{"key": "GoTerm", "value": "F:anthocyanidin reductase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016616", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0009813", "properties": [{"key": "GoTerm", "value": "P:flavonoid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.50.720", "properties": [{"key": "EntryName", "value": "NAD(P)-binding Rossmann-like Domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036291", "properties": [{"key": "EntryName", "value": "NAD(P)-bd_dom_sf"}]}, {"database": "InterPro", "id": "IPR050425", "properties": [{"key": "EntryName", "value": "NAD(P)_dehydrat-like"}]}, {"database": "PANTHER", "id": "PTHR10366:SF288", "properties": [{"key": "EntryName", "value": "ANTHOCYANIDIN REDUCTASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10366", "properties": [{"key": "EntryName", "value": "NAD DEPENDENT EPIMERASE/DEHYDRATASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF51735", "properties": [{"key": "EntryName", "value": "NAD(P)-binding Rossmann-fold domains"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIKPAIQGVLNVLKACARAKSVKRVVLTSSAAAVSINTLNGTGSVIDESNWTDVEFLSTAKPPTW", "length": 65, "molWeight": 6857, "crc64": "F05D2BAF1BE7D685", "md5": "249F43672AD3D4A0D55C14AD385AF10D"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D33F66"}, "cluster_size": 1, "family": "Fabaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZES1", "uniProtkbId": "A0AB38ZES1_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02787.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02787.1"}], "value": "Heteropteran venom family 13 protein 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 355, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044259399"}, {"type": "Coiled coil", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 53, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 85, "modifier": "EXACT"}, "end": {"value": 176, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02787.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517537", "properties": [{"key": "ProteinId", "value": "WXI02787.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.287.1490", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKMEGKQVLLLLVLLLIWQLNFANSNNNIDSQLEEVGQQIINLKRELANITSRAVNLGNYLDSLLKQTEGGGFVPPNHKGNSEKLNQLLNRIKYLQDNITELNSDLNNHVGDVNDIKMRTTSIEQELENLIKQIDEEKRDNNQSLVKYDSMIANLTSSYRNLVDELTKRLNEVERLLPYECIDAIINKNYFTAEMKINKVADDKVKFIVEQVISKGDANLDTLFILGHKLITNKKFLIYKELADIIIKKNIDYYCSYMKLFRLLQLEIISGTFGENIRAEAVKLVDKLVNRFKYLLNLPYVSQAGWNCSVEQYVSDNPIKFIQSCYGYRTHYIYNVFIGDSSITCRKHDYSDHGY", "length": 355, "molWeight": 41073, "crc64": "B5D982537B5421D8", "md5": "0F630FFEAF6221726B3BFB88A89869E6"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Coiled coil": 2}, "uniParcId": "UPI00388C2864"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96QC90", "uniProtkbId": "A0AA96QC90_9HEMI", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Empoasca flavescens", "taxonId": 317765, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNV59768.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Auchenorrhyncha", "Membracoidea", "Cicadellidae", "Typhlocybinae", "Empoascini", "Empoasca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNV59768.1"}], "value": "Mucin-like protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNV59768.1"}], "value": "MLP1"}}], "features": [{"type": "Region", "location": {"start": {"value": 428, "modifier": "EXACT"}, "end": {"value": 680, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 812, "modifier": "EXACT"}, "end": {"value": 1266, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 428, "modifier": "EXACT"}, "end": {"value": 474, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 494, "modifier": "EXACT"}, "end": {"value": 543, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 562, "modifier": "EXACT"}, "end": {"value": 612, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 632, "modifier": "EXACT"}, "end": {"value": 671, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 838, "modifier": "EXACT"}, "end": {"value": 888, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 908, "modifier": "EXACT"}, "end": {"value": 956, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 976, "modifier": "EXACT"}, "end": {"value": 986, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 993, "modifier": "EXACT"}, "end": {"value": 1025, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1045, "modifier": "EXACT"}, "end": {"value": 1094, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1114, "modifier": "EXACT"}, "end": {"value": 1164, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1184, "modifier": "EXACT"}, "end": {"value": 1234, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DTH9FOVLRRL4M", "citationType": "submission", "authors": ["Pan C.", "He X."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNV59768.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR504428", "properties": [{"key": "ProteinId", "value": "WNV59768.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MNLIQVNQVHQQQQPQSLKILLPQVKLLNLQQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVHQQQQPQSLKILQPQVKLLNLQQQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQLLQQQQPQSLKILLPQVKLLNLQRQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVHQQQQPQSLKILQPQVKLLNLQQQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVHQQQQPQSLKILQPQVKLLNLQQQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVHQQQQPQSLKILQPQVKLLNLQQQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVHQQQQPQSLKITTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESDSSESSTTTTTTESEDSTTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETVVSRDESDSSESSTSTTTTTESEDSTTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESDSSESSTSTTTTTESEDSTTTSETTESSTTTEQSSSTSESTSKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVLQQQQPQSLKIPLPQLLNLQQQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVHQQQQPQSLKILLPQVKLLNLQQQQNSLAALVSQLQKPQHNVSESSSEDSSEETTVVSRDESDSSESSTSTTTTTESEDSTTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESDSSESSTTTTTESEDSTTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESDSSESSTSTTTTTESEDSTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESDSSESSTSTTTTESEDSTTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESDSSESSTSTTTTTESEDSTTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESDSSESSTSTTTTTESEDSTTTSETTESSTTTEQSSSTSESTSETSTTTVVSESSSEDSSEETTVVSRDESDSSESHQQQQPQSLKIPLPQVKLLNLQRQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQVNQVLQQQQPQSLKIPLPQVKLLNLQRQQNSLAALVSQLQKPQPQLSFQNHHLKTQVRKQQLYHEMNLIQ", "length": 1392, "molWeight": 154030, "crc64": "3F6A4AB29DD63D51", "md5": "03284CC8BE6D16EB5D22AC4C8B5D2EB7"}, "extraAttributes": {"countByFeatureType": {"Region": 2, "Compositional bias": 11}, "uniParcId": "UPI002B291B5E"}, "cluster_size": 1, "family": "Cicadellidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QP72", "uniProtkbId": "A0AAU0QP72_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56511.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56511.1"}], "value": "Odorant receptor"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 39, "modifier": "EXACT"}, "end": {"value": 57, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 105, "modifier": "EXACT"}, "end": {"value": 124, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56511.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56511.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56511.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970404", "properties": [{"key": "ProteinId", "value": "WPO56511.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MDEKFSYLSVAHHIKYLQACGQYRLDKKSPEIWKFLHTIYMRSVLIFFVFYTFQQVLKINEVRDDIDKVMGTIFLFLTYTDWTYKCIIYWKKSEEINDLLDVMKGIWLFIFWEFKLFFYLFTYIGKYKECARLLSLRE", "length": 138, "molWeight": 17064, "crc64": "7A7C918C2ACC2A89", "md5": "455104B7CC0E985EEF00C9B1814AA306"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 3}, "uniParcId": "UPI00308C5258"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7EC95", "uniProtkbId": "A0AAU7EC95_TERTR", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Terebratalia transversa", "commonName": "Transverse lampshell", "taxonId": 34513, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48590.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Brachiopoda", "Rhynchonelliformea", "Rhynchonellata", "Terebratellidina", "Laqueoidea", "Laqueidae", "Terebratalia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "value": "Protein Wnt"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48590.1"}], "value": "wnt1t"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "value": "Ligand for members of the frizzled family of seven transmembrane receptors"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004498"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "value": "Secreted, extracellular space, extracellular matrix", "id": "SL-0111"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005683"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "value": "Belongs to the Wnt family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 35, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022530"}], "id": "KW-0272", "category": "Cellular component", "name": "Extracellular matrix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022687"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "id": "KW-0879", "category": "Biological process", "name": "Wnt signaling pathway"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AKIT4T8HERMEG", "citationType": "submission", "authors": ["Vellutini B.C.", "Martin-Duran J.M.", "Borve A.", "Hejnol A."], "title": "Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48590.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP860497", "properties": [{"key": "ProteinId", "value": "XBK48590.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005125", "properties": [{"key": "GoTerm", "value": "F:cytokine activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005109", "properties": [{"key": "GoTerm", "value": "F:frizzled binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0060070", "properties": [{"key": "GoTerm", "value": "P:canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045165", "properties": [{"key": "GoTerm", "value": "P:cell fate commitment"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030182", "properties": [{"key": "GoTerm", "value": "P:neuron differentiation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd13113", "properties": [{"key": "EntryName", "value": "Wnt"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.2460.20", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005817", "properties": [{"key": "EntryName", "value": "Wnt"}]}, {"database": "InterPro", "id": "IPR043158", "properties": [{"key": "EntryName", "value": "Wnt_C"}]}, {"database": "PANTHER", "id": "PTHR12027:SF97", "properties": [{"key": "EntryName", "value": "PROTEIN WNT-4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12027", "properties": [{"key": "EntryName", "value": "WNT RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00110", "properties": [{"key": "EntryName", "value": "wnt"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01349", "properties": [{"key": "EntryName", "value": "WNTPROTEIN"}]}, {"database": "SMART", "id": "SM00097", "properties": [{"key": "EntryName", "value": "WNT1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYSQRRSPKENMVKMFAATTSNLLKSLLVFGTFVFTKTAPRDSNIRFWAISEWAKQKPTNYKDNSVSLSTDLKFTSRQKRLIRRYPGILYGIADGVKMAIDACQSEFKYERWNCPIVDKTFKGTGFGEVLNSGYPEAGLIQALVSAGIAHKVARVCTDRTITACSCAHSPPSLASKEKLKARWTGCMPNINFGMHVSKVFMEGGYNIKRSRRQGNKNWNLKMMKHNFKAGRLHVQYGQNKTCSCGYMLTCALKTCTMQLDPFKEIVRKLKTQYFNAKSLHSKVNTTTTKGTKRRRQKHNQDDIVYHKKPPSYCQSVPHLQFKANYTRQCNGTQSDSSSSCTNLCCGRDYRTEYIVTNVKCKCRFVWCCYVKCQTCRKEVKRYYCLPPTNDPRFGISVG", "length": 398, "molWeight": 45511, "crc64": "BA1BC7588995A474", "md5": "2737642D611F14B93BDA5590F0A84195"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI0035D342FD"}, "cluster_size": 1, "family": "Laqueidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEL1", "uniProtkbId": "A0AB38ZEL1_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02694.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02694.1"}], "value": "Venom cystatin 2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 117, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044213210"}, {"type": "Domain", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 115, "modifier": "EXACT"}}, "description": "Cystatin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00043"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02694.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517444", "properties": [{"key": "ProteinId", "value": "WXI02694.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004869", "properties": [{"key": "GoTerm", "value": "F:cysteine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00042", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.450.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000010", "properties": [{"key": "EntryName", "value": "Cystatin_dom"}]}, {"database": "InterPro", "id": "IPR046350", "properties": [{"key": "EntryName", "value": "Cystatin_sf"}]}, {"database": "Pfam", "id": "PF00031", "properties": [{"key": "EntryName", "value": "Cystatin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00043", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54403", "properties": [{"key": "EntryName", "value": "Cystatin/monellin"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLKCASIILVFATVFLLNYGEATSPTKKTCLGCVQDIKLDDKGMRKSLAIVLKKQNAGVIILKIVSAKYQVVNGMKYTVEFEAKDTATKEKKYCSSTYISRPWKKEVKIIDFQCNSK", "length": 117, "molWeight": 13151, "crc64": "E58643949F8C2970", "md5": "95138C7B84FA913DED21C684D5D1B47F"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388BCF5F"}, "cluster_size": 3, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJM9", "uniProtkbId": "A0AAU7LJM9_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28281.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28281.1"}], "value": "MADS86"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28281.1"}], "value": "MADS86"}}], "features": [{"type": "Domain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 95, "modifier": "EXACT"}}, "description": "K-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51297"}]}, {"type": "Coiled coil", "location": {"start": {"value": 32, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28281.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28281.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400921", "properties": [{"key": "ProteinId", "value": "XBP28281.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR002487", "properties": [{"key": "EntryName", "value": "TF_Kbox"}]}, {"database": "Pfam", "id": "PF01486", "properties": [{"key": "EntryName", "value": "K-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51297", "properties": [{"key": "EntryName", "value": "K_BOX"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEKILERYERYCFAEKQLAGTAESQGNWTLEYSRLRARVELLQRNYRQYLGEDLDSRSLKEIQNLEQQLETSLKLVRSRKVFFFFYLFLYKKYYF", "length": 95, "molWeight": 11789, "crc64": "02A8B0ACF3613F62", "md5": "5F3839BA909FFD6067ABAA0ED5FC6849"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Coiled coil": 1}, "uniParcId": "UPI0035D2960F"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB32T2H4", "uniProtkbId": "A0AB32T2H4_DANRE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Danio rerio", "commonName": "Zebrafish", "synonyms": ["Brachydanio rerio"], "taxonId": 7955, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}, {"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068070058.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Cypriniformes", "Danionidae", "Danioninae", "Danio"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012423"}], "value": "palmitoyl-protein hydrolase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012423"}], "value": "3.1.2.22"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068070058.1"}, {"evidenceCode": "ECO:0000313", "source": "ZFIN", "id": "ZDB-GENE-050306-32"}], "value": "lyplal1"}, "synonyms": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068070058.1"}], "value": "si:dkey-275d24.1"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068070058.1"}], "value": "zgc:110848"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006499"}], "value": "Belongs to the AB hydrolase superfamily. AB hydrolase 2 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 8, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "Phospholipase/carboxylesterase/thioesterase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02230"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AB32T2H4"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "23594743", "citationType": "journal article", "authoringGroup": ["Genome Reference Consortium Zebrafish"], "authors": ["Howe K.", "Clark M.D.", "Torroja C.F.", "Torrance J.", "Berthelot C.", "Muffato M.", "Collins J.E.", "Humphray S.", "McLaren K.", "Matthews L.", "McLaren S.", "Sealy I.", "Caccamo M.", "Churcher C.", "Scott C.", "Barrett J.C.", "Koch R.", "Rauch G.J.", "White S.", "Chow W.", "Kilian B.", "Quintais L.T.", "Guerra-Assuncao J.A.", "Zhou Y.", "Gu Y.", "Yen J.", "Vogel J.H.", "Eyre T.", "Redmond S.", "Banerjee R.", "Chi J.", "Fu B.", "Langley E.", "Maguire S.F.", "Laird G.K.", "Lloyd D.", "Kenyon E.", "Donaldson S.", "Sehra H.", "Almeida-King J.", "Loveland J.", "Trevanion S.", "Jones M.", "Quail M.", "Willey D.", "Hunt A.", "Burton J.", "Sims S.", "McLay K.", "Plumb B.", "Davis J.", "Clee C.", "Oliver K.", "Clark R.", "Riddle C.", "Elliot D.", "Eliott D.", "Threadgold G.", "Harden G.", "Ware D.", "Begum S.", "Mortimore B.", "Mortimer B.", "Kerry G.", "Heath P.", "Phillimore B.", "Tracey A.", "Corby N.", "Dunn M.", "Johnson C.", "Wood J.", "Clark S.", "Pelan S.", "Griffiths G.", "Smith M.", "Glithero R.", "Howden P.", "Barker N.", "Lloyd C.", "Stevens C.", "Harley J.", "Holt K.", "Panagiotidis G.", "Lovell J.", "Beasley H.", "Henderson C.", "Gordon D.", "Auger K.", "Wright D.", "Collins J.", "Raisen C.", "Dyer L.", "Leung K.", "Robertson L.", "Ambridge K.", "Leongamornlert D.", "McGuire S.", "Gilderthorp R.", "Griffiths C.", "Manthravadi D.", "Nichol S.", "Barker G.", "Whitehead S.", "Kay M.", "Brown J.", "Murnane C.", "Gray E.", "Humphries M.", "Sycamore N.", "Barker D.", "Saunders D.", "Wallis J.", "Babbage A.", "Hammond S.", "Mashreghi-Mohammadi M.", "Barr L.", "Martin S.", "Wray P.", "Ellington A.", "Matthews N.", "Ellwood M.", "Woodmansey R.", "Clark G.", "Cooper J.", "Cooper J.", "Tromans A.", "Grafham D.", "Skuce C.", "Pandian R.", "Andrews R.", "Harrison E.", "Kimberley A.", "Garnett J.", "Fosker N.", "Hall R.", "Garner P.", "Kelly D.", "Bird C.", "Palmer S.", "Gehring I.", "Berger A.", "Dooley C.M.", "Ersan-Urun Z.", "Eser C.", "Geiger H.", "Geisler M.", "Karotki L.", "Kirn A.", "Konantz J.", "Konantz M.", "Oberlander M.", "Rudolph-Geiger S.", "Teucke M.", "Lanz C.", "Raddatz G.", "Osoegawa K.", "Zhu B.", "Rapp A.", "Widaa S.", "Langford C.", "Yang F.", "Schuster S.C.", "Carter N.P.", "Harrow J.", "Ning Z.", "Herrero J.", "Searle S.M.", "Enright A.", "Geisler R.", "Plasterk R.H.", "Lee C.", "Westerfield M.", "de Jong P.J.", "Zon L.I.", "Postlethwait J.H.", "Nusslein-Volhard C.", "Hubbard T.J.", "Roest Crollius H.", "Rogers J.", "Stemple D.L."], "citationCrossReferences": [{"database": "PubMed", "id": "23594743"}, {"database": "DOI", "id": "10.1038/nature12111"}], "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "publicationDate": "2013", "journal": "Nature", "firstPage": "498", "lastPage": "503", "volume": "496"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FT6AD0HQEQTFJ", "citationType": "submission", "authoringGroup": ["RefSeq"], "publicationDate": "APR-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068070058.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068070058.1"}]}], "uniProtKBCrossReferences": [{"database": "RefSeq", "id": "XP_068070058.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_068213957.1"}]}, {"database": "CTD", "id": "127018", "properties": [{"key": "Description", "value": "-"}]}, {"database": "ZFIN", "id": "ZDB-GENE-050306-32", "properties": [{"key": "GeneName", "value": "lyplal1"}]}, {"database": "Proteomes", "id": "UP000000437", "properties": [{"key": "Component", "value": "Chromosome 16"}]}, {"database": "GO", "id": "GO:0016787", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.50.1820", "properties": [{"key": "EntryName", "value": "alpha/beta hydrolase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR029058", "properties": [{"key": "EntryName", "value": "AB_hydrolase_fold"}]}, {"database": "InterPro", "id": "IPR050565", "properties": [{"key": "EntryName", "value": "LYPA1-2/EST-like"}]}, {"database": "InterPro", "id": "IPR003140", "properties": [{"key": "EntryName", "value": "PLipase/COase/thioEstase"}]}, {"database": "PANTHER", "id": "PTHR10655:SF17", "properties": [{"key": "EntryName", "value": "LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10655", "properties": [{"key": "EntryName", "value": "LYSOPHOSPHOLIPASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02230", "properties": [{"key": "EntryName", "value": "Abhydrolase_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53474", "properties": [{"key": "EntryName", "value": "alpha/beta-Hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAAVKLQKSVVSQAGKHTASVIFLHGSGDTGPGLRSWVLDVLGQNLAFENIRVIYPTAPLRPYTPMRGAPSHVWFDRHKISQHCPEHLESIDSMCDHLGDIVQDELRAGIPKHRMVIGGFSMGGAMALHLVCRHHQDIAGIFCLSSFLNKDSAVYQFFFVSPFSLSLPAVCRRNVSHTLPLLLLEPDCRER", "length": 191, "molWeight": 21195, "crc64": "E24D5ACB940DFF31", "md5": "99482529B0C59863F454CE37039EE7D0"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035A093C6"}, "cluster_size": 4, "family": "Danionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTV2", "uniProtkbId": "A0AAT9UTV2_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41707.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41707.1"}], "value": "Cytochrome P450 4461L1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 386, "modifier": "EXACT"}, "end": {"value": 386, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41707.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117267", "properties": [{"key": "ProteinId", "value": "WIM41707.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNYFFKNVEKHMQSYDRLVFWMSSYPCVVLKKQEDISLILSQCQDRESLGFLNEWFGTGILTLKYDEWKKSRKTLAPAFTSEMLAIYVHVFNERSAALVDKFKSAADAGLIIDVWDHVMNTNVDIITENVLGASIQSTGKIGHDFSYAIKRAIDSTVKRILSPWLHSRIVYWIYLKLTGESELIKKFHDLPTYIVTKKLNDFRTRKSHIDEINSSKRIIDLLIKAHFNDPFTFTETRIRDELISLMGAGTETTTTTVVFTMLMLAIHQDIQQKVYEEFAQLIGNQEITVDHFTKPLKYLEQCIAETSRLYSQITLTARKTTKECKLHDNTIVPDNVIVFLLTSLVHYEEKYYKSSRTWDPENFNEQAVAARPKSSVLTFGYGARSCLGNQYSMLLAKSQLIHILRNYHLSTNIQKLTRDDLEMDLLIKSKFGYPIKFVKRTGPVQK", "length": 446, "molWeight": 51639, "crc64": "2E06B7C1A397FC5D", "md5": "6FEBCD2DE1BEC3DE8EB5ECF73D021C2D"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D2866F"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLN3", "uniProtkbId": "A0AAU0QLN3_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56533.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56533.1"}], "value": "Ionotropic receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 122, "modifier": "EXACT"}, "end": {"value": 142, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56533.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56533.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56533.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970333", "properties": [{"key": "ProteinId", "value": "WPO56533.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR052192", "properties": [{"key": "EntryName", "value": "Insect_Ionotropic_Sensory_Rcpt"}]}, {"database": "PANTHER", "id": "PTHR42643", "properties": [{"key": "EntryName", "value": "IONOTROPIC RECEPTOR 20A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR42643:SF32", "properties": [{"key": "EntryName", "value": "IONOTROPIC RECEPTOR 31A, ISOFORM C-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYSTKSAAGRDHNFLSAERGMELVKKGGFAFHVDSVVAYRIMRSKFTEREICEAHEIPLYPPQKMGFVVRKASPLKEHFTYGVRKLLESGLMRRLQSTWDEPKPACVHTPDASVFSVSIREFSTALLALLGGVIISLVVLFAEIITHRCRNGQIAFIH", "length": 158, "molWeight": 17794, "crc64": "D48D3FBB5EF75BFA", "md5": "7891AC5D539B09A78709A966FE38545F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI003091F404"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZES0", "uniProtkbId": "A0AB38ZES0_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02794.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02794.1"}], "value": "Heteropteran venom family 14 protein 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 407, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044314729"}, {"type": "Region", "location": {"start": {"value": 120, "modifier": "EXACT"}, "end": {"value": 278, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 143, "modifier": "EXACT"}, "end": {"value": 158, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 163, "modifier": "EXACT"}, "end": {"value": 184, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 185, "modifier": "EXACT"}, "end": {"value": 200, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 202, "modifier": "EXACT"}, "end": {"value": 222, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 230, "modifier": "EXACT"}, "end": {"value": 254, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 261, "modifier": "EXACT"}, "end": {"value": 278, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02794.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517544", "properties": [{"key": "ProteinId", "value": "WXI02794.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MRFKLVLLLLFVTLFTLIGALPSNIDNGKFNSDQKPMFTSIDGKSYETEANKYEEPFNIDGITGNRIGSYGHITALVGIKGIPRFLEKPQVISTTRLSIAHSVPNIQESAHMKGIVKRSITEDNKENQDVSATDAETNKNEDSNTVTADNTESNNQVKELSETETNSEINNQQTNNNENTNENSVNPAESETTATENNINEDTDKITGENNEKVDVENEKLTNGDTGNVVKDEEKEKESIVEKEKEDKEGKEIIDEGNEQNQKEVIEENKPDQNEKESKKSLPLLYILTLIQSSKGNEKITSKDIENLIASIKEKLESNINHKLNQNGDLDYSITVNIGQIPSDNIKKEPITTGKKEKCKKGKKGPFKKFGKKPWWFFRKNGKDKKIDDHFTSMMKNLVQGWRRSTS", "length": 407, "molWeight": 45873, "crc64": "AD3140C17165B025", "md5": "BC454EFF2D2BE587CEF4A85B8B70E7F9"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1, "Compositional bias": 6}, "uniParcId": "UPI00388C221D"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMQ9", "uniProtkbId": "A0AAU0QMQ9_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56491.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56491.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 39, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 112, "modifier": "EXACT"}, "end": {"value": 131, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56491.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56491.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56491.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56491.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970384", "properties": [{"key": "ProteinId", "value": "WPO56491.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VIACSFSVFAQIQGGIVIDGWFPFDPFENHWTALLASQIMGILFVVPLLIRAVALQGIVCSVIMYMCDQLKELQKRLRELKFTVGNESLMREEFKNIIEKHMRLVRYEKFGFFYYLLYDFLSSFYCVWLSFLRVSNANSLTPSYHSTHAHLHTQHSH", "length": 157, "molWeight": 18346, "crc64": "E1F00AF925E1E357", "md5": "3A567E236B57FD08B1D5943B4679F4E1"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 1}, "uniParcId": "UPI00308624F3"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N6I4", "uniProtkbId": "A0AAN0N6I4_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34092.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34092.1"}], "value": "Orexin receptor 2-like GPCR protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 112, "modifier": "EXACT"}, "end": {"value": 137, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 149, "modifier": "EXACT"}, "end": {"value": 168, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 188, "modifier": "EXACT"}, "end": {"value": 207, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 228, "modifier": "EXACT"}, "end": {"value": 246, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 277, "modifier": "EXACT"}, "end": {"value": 300, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 599, "modifier": "EXACT"}, "end": {"value": 617, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 637, "modifier": "EXACT"}, "end": {"value": 657, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 128, "modifier": "EXACT"}, "end": {"value": 654, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34092.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155018", "properties": [{"key": "ProteinId", "value": "WRW34092.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016499", "properties": [{"key": "GoTerm", "value": "F:orexin receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007631", "properties": [{"key": "GoTerm", "value": "P:feeding behavior"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR000204", "properties": [{"key": "EntryName", "value": "Orexin_rcpt"}]}, {"database": "PANTHER", "id": "PTHR45695", "properties": [{"key": "EntryName", "value": "LEUCOKININ RECEPTOR-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45695:SF15", "properties": [{"key": "EntryName", "value": "OPSIN RH2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "PRINTS", "id": "PR01064", "properties": [{"key": "EntryName", "value": "OREXINR"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLSLNNLTTFENQLNQSFLNENNLIKNLTESYQNQTSENILRQISSFTNEIIKDVILNNSTSSLKETKINLNESAQICLNSSSQNNETTECYDKEEYQKILEDYIYPAHYEFVLIALHIIVFFVGLVGNVLVCISVYRNHTMRNVVNYFIVNLAVADFLVILICLPPTVLWDVTETWWLGNSMCKTVLYFQGVSVFVSILTLTFISIDRWYAICHPLRFKCTTAKARIVIAFIWLTSLSIMVPEFIDLHIEPSPFAKQLDKPYFTDCRLSWSDKTQLIYQIIIVSLLFIIPFSLMSIAYYQIAKVLWIKSIPGSAERCSPTKNKKKSLKYCFTQNLNKFIQKSCCNLCSKKKTKKNISCHFNNSLINDEQRNNLYFKIDTSNNITKNFQGLNQKNLNNDRYSAQLKRSSSANINEENNIPQSTKVLSNICNLEQLKFIDDKDSNQTINEKINERTNEEETNKNSNSLPKENFFQSTITKFIQIKLNIQRIFGLKKKLKTNELQLSDNINNKQNLNDNQTDDNFETTNFIQSRRTNVKKDKINRASTPVQLIYTEQNSFKRIRRMTVPGNRLSSFISTNQADSRVNCEGHVQSRRKAAKMLIAVVVMFGFCYLPLHIINTLRYTIGLPQNDITTVASLISHWLCYANSALNPIIYNFMSGKFRREFKNAFACMCFRKKKKSIDLKGTQRQLTTIHNRRNFKNQSRIINKPKQLINYENNKNLVNSNLVTQNLLNENVNDQKLYNQNLIKRNDGTSLDSHSLDDMNFKHQNNQNLKIKNQIIKT", "length": 782, "molWeight": 90761, "crc64": "D3B9B1F4A58409B9", "md5": "FF886DE34FFD819BD28753AD1EBCF767"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI00325347A8"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI23", "uniProtkbId": "A0AA96MI23_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50056.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50056.1"}], "value": "Uncharacterized protein 10"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 54, "modifier": "EXACT"}, "end": {"value": 130, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 58, "modifier": "EXACT"}, "end": {"value": 68, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 76, "modifier": "EXACT"}, "end": {"value": 86, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50056.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460133", "properties": [{"key": "ProteinId", "value": "WNS50056.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MGNNVRPTRPRQPTRYGDKLQRGQPARHMFGPLGPRVGQWARWVVPLLVRVVFGPPRIPDDHWPRRPPAEPQPEDPTTKPKQEGSPKKPQPAECPNTKPKSEGSTTKPKPEPAETGRQNGSAEDFPDVDD", "length": 130, "molWeight": 14535, "crc64": "CD91474562E4120B", "md5": "2D2CA1F0EF3F00C7E6EF9DCB8B796EE0"}, "extraAttributes": {"countByFeatureType": {"Region": 2, "Compositional bias": 2}, "uniParcId": "UPI002B2A46EF"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S1R6", "uniProtkbId": "A0AA96S1R6_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50091.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "value": "Galectin"}}}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 174, "modifier": "EXACT"}}, "description": "Galectin", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041681618"}, {"type": "Domain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 174, "modifier": "EXACT"}}, "description": "Galectin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51304"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022734"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "id": "KW-0430", "category": "Ligand", "name": "Lectin"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50091.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460168", "properties": [{"key": "ProteinId", "value": "WNS50091.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0030246", "properties": [{"key": "GoTerm", "value": "F:carbohydrate binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "Gene3D", "id": "2.60.120.200", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR013320", "properties": [{"key": "EntryName", "value": "ConA-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR001079", "properties": [{"key": "EntryName", "value": "Galectin_CRD"}]}, {"database": "Pfam", "id": "PF00337", "properties": [{"key": "EntryName", "value": "Gal-bind_lectin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00276", "properties": [{"key": "EntryName", "value": "GLECT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49899", "properties": [{"key": "EntryName", "value": "Concanavalin A-like lectins/glucanases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51304", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDRVWKLIVIVAVFGAEKASASQLRGIDTPAGFEPDDELQVGYSLPDTDRTTVNLFDAAGGFVLHVDYRVHFRSNNYIVVINSKPSNGGWGTETRINDLPFREGDSVALVVTRTDENTFQITFGQFPDERTISYTSRLPCADVRRIQWSGPDSTDFGYMFVWSTSSDKYIQVEV", "length": 174, "molWeight": 19557, "crc64": "5D2C0A631B420957", "md5": "4DD877334219361A14C6359189D116EC"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B2A685F"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZE95", "uniProtkbId": "A0AB38ZE95_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71742.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71742.1"}], "value": "Venom triabin 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034121"}], "value": "Belongs to the calycin superfamily. Triabin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 208, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044277553"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71742.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510817", "properties": [{"key": "ProteinId", "value": "WXH71742.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0006629", "properties": [{"key": "GoTerm", "value": "P:lipid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000302", "properties": [{"key": "GoTerm", "value": "P:response to reactive oxygen species"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030682", "properties": [{"key": "GoTerm", "value": "P:symbiont-mediated perturbation of host defenses"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "2.40.128.20", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR012674", "properties": [{"key": "EntryName", "value": "Calycin"}]}, {"database": "InterPro", "id": "IPR005657", "properties": [{"key": "EntryName", "value": "Triabi/Procalin"}]}, {"database": "PANTHER", "id": "PTHR10612", "properties": [{"key": "EntryName", "value": "APOLIPOPROTEIN D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10612:SF34", "properties": [{"key": "EntryName", "value": "APOLIPOPROTEIN D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03973", "properties": [{"key": "EntryName", "value": "Triabin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50814", "properties": [{"key": "EntryName", "value": "Lipocalins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEFKFSSFFFISLFIFAGFVISTKASIIKKQECKVYQPMQGFDKSKFFSGSWYTTHIQKIYLTSKDVCQKFKFQISSDGSIQQITKFYLEEIKGLINAEGPITSDSNFGDGLGVFNWTFHFVRDGKRVDDNTFTFPITVLDTDYDNYAILYSCRVIFNFLLIDELSILRRDKEAELNPKIKEVLSKAGVDFDKLSSRKSVECPEDPNF", "length": 208, "molWeight": 24029, "crc64": "3522A4CE3E69120E", "md5": "458BB6E9446D1BFDE79B056505DE9337"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BEB99"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QKX1", "uniProtkbId": "A0AAU0QKX1_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56477.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56477.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 53, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 73, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 121, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56477.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56477.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56477.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56477.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970370", "properties": [{"key": "ProteinId", "value": "WPO56477.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MDLNNYTFDNIFKITVKSMYYNYSHPFLERTLSWIIKFVIIQTILITCFVFLMNSVLFYDIPSGNYSDATKNGTMSIVSLTITIKYAFLIYFKSHISSYIKIMNKDFILALDFELFEKDIV", "length": 121, "molWeight": 14282, "crc64": "B786F70AFC3B2DD1", "md5": "5D8A7A375EDCA46800C96F550A479306"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 1}, "uniParcId": "UPI00308DE99F"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7EA93", "uniProtkbId": "A0AAU7EA93_TERTR", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Terebratalia transversa", "commonName": "Transverse lampshell", "taxonId": 34513, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48599.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Brachiopoda", "Rhynchonelliformea", "Rhynchonellata", "Terebratellidina", "Laqueoidea", "Laqueidae", "Terebratalia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "value": "Protein Wnt"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48599.1"}], "value": "wnt11"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "value": "Ligand for members of the frizzled family of seven transmembrane receptors"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004498"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "value": "Secreted, extracellular space, extracellular matrix", "id": "SL-0111"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005683"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "value": "Belongs to the Wnt family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022530"}], "id": "KW-0272", "category": "Cellular component", "name": "Extracellular matrix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023288"}], "id": "KW-0449", "category": "PTM", "name": "Lipoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022687"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003500"}], "id": "KW-0879", "category": "Biological process", "name": "Wnt signaling pathway"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AKIT4T8HERMEG", "citationType": "submission", "authors": ["Vellutini B.C.", "Martin-Duran J.M.", "Borve A.", "Hejnol A."], "title": "Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48599.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP860506", "properties": [{"key": "ProteinId", "value": "XBK48599.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005125", "properties": [{"key": "GoTerm", "value": "F:cytokine activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005109", "properties": [{"key": "GoTerm", "value": "F:frizzled binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0060070", "properties": [{"key": "GoTerm", "value": "P:canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045165", "properties": [{"key": "GoTerm", "value": "P:cell fate commitment"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030182", "properties": [{"key": "GoTerm", "value": "P:neuron differentiation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd19343", "properties": [{"key": "EntryName", "value": "Wnt_Wnt11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.2460.20:FF:000001", "properties": [{"key": "EntryName", "value": "Wnt homolog"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.2460.20", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005817", "properties": [{"key": "EntryName", "value": "Wnt"}]}, {"database": "InterPro", "id": "IPR043158", "properties": [{"key": "EntryName", "value": "Wnt_C"}]}, {"database": "InterPro", "id": "IPR018161", "properties": [{"key": "EntryName", "value": "Wnt_CS"}]}, {"database": "PANTHER", "id": "PTHR12027:SF102", "properties": [{"key": "EntryName", "value": "PROTEIN WNT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12027", "properties": [{"key": "EntryName", "value": "WNT RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00110", "properties": [{"key": "EntryName", "value": "wnt"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01349", "properties": [{"key": "EntryName", "value": "WNTPROTEIN"}]}, {"database": "SMART", "id": "SM00097", "properties": [{"key": "EntryName", "value": "WNT1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00246", "properties": [{"key": "EntryName", "value": "WNT1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MELRLYCKNTGKLLFFLHVLYQTSEAIRWIGIARKPKHLSSWNTTSDCSTSRKYGLMAAQVEICKGHLDLMDSVIHAAKLSTRTCTNIFKATRWNCSSLLQTPKVTPDLNTGTREQAYVYSISSAAMTHSIARTCSLGLTQRCGCGRLPDSPTSLKFKWDGCSDNMPYGIKFATMFGDAPYNHVKYRRTKRSKKALMNQHNMISGRKVVIDSLLVKCKCHGVSGSCALKSCWQALPSFMAIGEKLRKKYQLAVAVTKKKVRNNRQLVPISRQRRAFRDDELVFINASPDYCNPDKSTGSVGTRGRLCDKYSRDSFGCGSMCCGRGFWTRHYTKFERCHCKYIWCCYVKCQKCLKSATDYRCR", "length": 362, "molWeight": 41147, "crc64": "4DE61DA9880BCDA9", "md5": "09990997BEAE6590FC50B8B1214797F9"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "uniParcId": "UPI0035D318F7"}, "cluster_size": 1, "family": "Laqueidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P2S6", "uniProtkbId": "A0AAU7P2S6_CALMC", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Callistoctopus minor", "commonName": "Octopus", "synonyms": ["Octopus minor"], "taxonId": 515824, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35916.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Cephalopoda", "Coleoidea", "Octopodiformes", "Octopoda", "Incirrata", "Octopodidae", "Callistoctopus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35916.1"}], "value": "Tyrosine-3-monooxygenase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35916.1"}], "value": "TH"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Fe(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001954"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29033"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009712"}], "value": "Belongs to the biopterin-dependent aromatic amino acid hydroxylase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 180, "modifier": "EXACT"}}, "description": "Biopterin-dependent aromatic amino acid hydroxylase family profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00351"}]}, {"type": "Domain", "location": {"start": {"value": 183, "modifier": "EXACT"}, "end": {"value": 231, "modifier": "EXACT"}}, "description": "Biopterin-dependent aromatic amino acid hydroxylase family profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00351"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B1PARK2TANKH3", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS35916.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP889617", "properties": [{"key": "ProteinId", "value": "XBS35916.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043005", "properties": [{"key": "GoTerm", "value": "C:neuron projection"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004510", "properties": [{"key": "GoTerm", "value": "F:tryptophan 5-monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0009072", "properties": [{"key": "GoTerm", "value": "P:aromatic amino acid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.800.10", "properties": [{"key": "EntryName", "value": "Aromatic amino acid hydroxylase"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001273", "properties": [{"key": "EntryName", "value": "ArAA_hydroxylase"}]}, {"database": "InterPro", "id": "IPR036951", "properties": [{"key": "EntryName", "value": "ArAA_hydroxylase_sf"}]}, {"database": "InterPro", "id": "IPR036329", "properties": [{"key": "EntryName", "value": "Aro-AA_hydroxylase_C_sf"}]}, {"database": "InterPro", "id": "IPR019774", "properties": [{"key": "EntryName", "value": "Aromatic-AA_hydroxylase_C"}]}, {"database": "PANTHER", "id": "PTHR11473", "properties": [{"key": "EntryName", "value": "AROMATIC AMINO ACID HYDROXYLASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11473:SF16", "properties": [{"key": "EntryName", "value": "TRYPTOPHAN 5-HYDROXYLASE 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00351", "properties": [{"key": "EntryName", "value": "Biopterin_H"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF56534", "properties": [{"key": "EntryName", "value": "Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNCSNNSDAENDTTKRRLAFQKCYSLEHGGNWRRKSLIEDARFETVTNAEFERSEERRLGECISEESEQFNGEGKSRLESTKLQVMHIETRVSKQAGSNFDVFIQCVGKKVSINQCIELLDRNTKVQSTTILDESPKEKVREYRRRRKVIADMAFSYRHNVSIPRIEYTEEEVKTCDCVHELKYVAQIKRPYEFHYDAFTQSLVELKDKQALQTMIRKIKVNVDSVQKALKLLEVRTVQVTA", "length": 242, "molWeight": 28254, "crc64": "555C935484B847A9", "md5": "474B34C2ADA4623D0EE8BDA8A7DDB675"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2}, "uniParcId": "UPI0035D30A96"}, "cluster_size": 1, "family": "Octopodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BI39", "uniProtkbId": "A0AAQ5BI39_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519752.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519752.1"}], "value": "Transmembrane serine protease 11A"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519752.1"}], "value": "TMPRSS11A"}}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 44, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 47, "modifier": "EXACT"}, "end": {"value": 114, "modifier": "EXACT"}}, "description": "SEA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50024"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BI39"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BI39"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519752.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519752.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15815621", "citationType": "journal article", "authors": ["Hillier L.W.", "Graves T.A.", "Fulton R.S.", "Fulton L.A.", "Pepin K.H.", "Minx P.", "Wagner-McPherson C.", "Layman D.", "Wylie K.", "Sekhon M.", "Becker M.C.", "Fewell G.A.", "Delehaunty K.D.", "Miner T.L.", "Nash W.E.", "Kremitzki C.", "Oddy L.", "Du H.", "Sun H.", "Bradshaw-Cordum H.", "Ali J.", "Carter J.", "Cordes M.", "Harris A.", "Isak A.", "van Brunt A.", "Nguyen C.", "Du F.", "Courtney L.", "Kalicki J.", "Ozersky P.", "Abbott S.", "Armstrong J.", "Belter E.A.", "Caruso L.", "Cedroni M.", "Cotton M.", "Davidson T.", "Desai A.", "Elliott G.", "Erb T.", "Fronick C.", "Gaige T.", "Haakenson W.", "Haglund K.", "Holmes A.", "Harkins R.", "Kim K.", "Kruchowski S.S.", "Strong C.M.", "Grewal N.", "Goyea E.", "Hou S.", "Levy A.", "Martinka S.", "Mead K.", "McLellan M.D.", "Meyer R.", "Randall-Maher J.", "Tomlinson C.", "Dauphin-Kohlberg S.", "Kozlowicz-Reilly A.", "Shah N.", "Swearengen-Shahid S.", "Snider J.", "Strong J.T.", "Thompson J.", "Yoakum M.", "Leonard S.", "Pearman C.", "Trani L.", "Radionenko M.", "Waligorski J.E.", "Wang C.", "Rock S.M.", "Tin-Wollam A.M.", "Maupin R.", "Latreille P.", "Wendl M.C.", "Yang S.P.", "Pohl C.", "Wallis J.W.", "Spieth J.", "Bieri T.A.", "Berkowicz N.", "Nelson J.O.", "Osborne J.", "Ding L.", "Meyer R.", "Sabo A.", "Shotland Y.", "Sinha P.", "Wohldmann P.E.", "Cook L.L.", "Hickenbotham M.T.", "Eldred J.", "Williams D.", "Jones T.A.", "She X.", "Ciccarelli F.D.", "Izaurralde E.", "Taylor J.", "Schmutz J.", "Myers R.M.", "Cox D.R.", "Huang X.", "McPherson J.D.", "Mardis E.R.", "Clifton S.W.", "Warren W.C.", "Chinwalla A.T.", "Eddy S.R.", "Marra M.A.", "Ovcharenko I.", "Furey T.S.", "Miller W.", "Eichler E.E.", "Bork P.", "Suyama M.", "Torrents D.", "Waterston R.H.", "Wilson R.K."], "citationCrossReferences": [{"database": "PubMed", "id": "15815621"}, {"database": "DOI", "id": "10.1038/nature03466"}], "title": "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.", "publicationDate": "2005", "journal": "Nature", "firstPage": "724", "lastPage": "731", "volume": "434"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519752.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519752.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC096653", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AC096727", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BI39", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714500.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519752.1"}, {"key": "GeneId", "value": "ENSG00000187054.17"}]}, {"database": "HGNC", "id": "HGNC:27954", "properties": [{"key": "GeneName", "value": "TMPRSS11A"}]}, {"database": "OpenTargets", "id": "ENSG00000187054", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000161698", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 4"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.30.70.960", "properties": [{"key": "EntryName", "value": "SEA domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000082", "properties": [{"key": "EntryName", "value": "SEA_dom"}]}, {"database": "InterPro", "id": "IPR036364", "properties": [{"key": "EntryName", "value": "SEA_dom_sf"}]}, {"database": "Pfam", "id": "PF01390", "properties": [{"key": "EntryName", "value": "SEA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF82671", "properties": [{"key": "EntryName", "value": "SEA domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50024", "properties": [{"key": "EntryName", "value": "SEA"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTCCNNPSN", "length": 114, "molWeight": 13232, "crc64": "FCA9110871111C89", "md5": "47EC9837ED42477D7636B160E7635761"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Domain": 1}, "uniParcId": "UPI0032CD7BDC"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N6H2", "uniProtkbId": "A0AAJ6N6H2_9CYAN", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Anthocerotibacter panamensis", "taxonId": 2857077, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8IMO"}], "lineage": ["Bacteria", "Bacillati", "Cyanobacteriota", "Cyanophyceae", "Gloeobacterales", "Anthocerotibacteraceae", "Anthocerotibacter"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8IML"}, {"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8IMM"}], "value": "CpcD"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004445"}], "value": "Cellular thylakoid membrane", "id": "SL-0045"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004445"}], "value": "Peripheral membrane protein", "id": "SL-9903"}, "orientation": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004445"}], "value": "Cytoplasmic side", "id": "SL-9910"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 76, "modifier": "EXACT"}}, "description": "CpcD-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51441"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IML"}, {"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IMM"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022549"}], "id": "KW-0042", "category": "Cellular component", "name": "Antenna complex"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022738"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00771"}], "id": "KW-0605", "category": "Cellular component", "name": "Phycobilisome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023078"}], "id": "KW-0793", "category": "Cellular component", "name": "Thylakoid"}], "references": [{"referenceNumber": 1, "citation": {"id": "38049400", "citationType": "journal article", "authors": ["Jiang H.W.", "Wu H.Y.", "Wang C.H.", "Yang C.H.", "Ko J.T.", "Ho H.C.", "Tsai M.D.", "Bryant D.A.", "Li F.W.", "Ho M.C.", "Ho M.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "38049400"}, {"database": "DOI", "id": "10.1038/s41467-023-43646-9"}], "title": "A structure of the relict phycobilisome from a thylakoid-free cyanobacterium.", "publicationDate": "2023", "journal": "Nat. Commun.", "firstPage": "8009", "lastPage": "8009", "volume": "14"}, "referencePositions": ["STRUCTURE BY ELECTRON MICROSCOPY (2.74 ANGSTROMS)"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IML"}, {"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8IMM"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8IML", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "2.74 A"}, {"key": "Chains", "value": "M/Z/m=1-78"}]}, {"database": "PDB", "id": "8IMM", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "2.76 A"}, {"key": "Chains", "value": "M/Z/m=1-78"}]}, {"database": "PDB", "id": "8IMN", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "3.07 A"}, {"key": "Chains", "value": "M/Z/m=1-78"}]}, {"database": "PDB", "id": "8IMO", "properties": [{"key": "Method", "value": "EM"}, {"key": "Resolution", "value": "3.08 A"}, {"key": "Chains", "value": "M/Z/m=1-78"}]}, {"database": "SMR", "id": "A0AAJ6N6H2", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0030089", "properties": [{"key": "GoTerm", "value": "C:phycobilisome"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0031676", "properties": [{"key": "GoTerm", "value": "C:plasma membrane-derived thylakoid membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "InterPro", "id": "IPR008213", "properties": [{"key": "EntryName", "value": "CpcD-like_dom"}]}, {"database": "Pfam", "id": "PF01383", "properties": [{"key": "EntryName", "value": "CpcD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01094", "properties": [{"key": "EntryName", "value": "CpcD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51441", "properties": [{"key": "EntryName", "value": "CPCD_LIKE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYGQSTSDEAITTQGKRIYKITVSEAGAYATNKHRTGYRAPIRQSNYTLTVPYDRFLPEMIRLHQSGAKIVNVTSVIS", "length": 78, "molWeight": 8753, "crc64": "D7611C5C5EB05ED1", "md5": "A2B8B2FAFB835246641D17A44C5FB46E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI001C4043C7"}, "cluster_size": 1, "family": "Anthocerotibacteraceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJJ7", "uniProtkbId": "A0AAU7LJJ7_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28277.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28277.1"}], "value": "MADS82"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28277.1"}], "value": "MADS82"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00024045"}], "value": "Belongs to the HIPP family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 49, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}, {"type": "Domain", "location": {"start": {"value": 175, "modifier": "EXACT"}, "end": {"value": 238, "modifier": "EXACT"}}, "description": "HMA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50846"}]}, {"type": "Domain", "location": {"start": {"value": 267, "modifier": "EXACT"}, "end": {"value": 330, "modifier": "EXACT"}}, "description": "HMA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50846"}]}, {"type": "Region", "location": {"start": {"value": 333, "modifier": "EXACT"}, "end": {"value": 362, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 336, "modifier": "EXACT"}, "end": {"value": 362, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023289"}], "id": "KW-0449", "category": "PTM", "name": "Lipoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022481"}], "id": "KW-0488", "category": "PTM", "name": "Methylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023289"}], "id": "KW-0636", "category": "PTM", "name": "Prenylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28277.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28277.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400917", "properties": [{"key": "ProteinId", "value": "XBP28277.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000987", "properties": [{"key": "GoTerm", "value": "F:cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00371", "properties": [{"key": "EntryName", "value": "HMA"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "CDD", "id": "cd00266", "properties": [{"key": "EntryName", "value": "MADS_SRF_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.1810.10:FF:000024", "properties": [{"key": "EntryName", "value": "Agamous-like MADS-box protein AGL80"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.70.100", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR044577", "properties": [{"key": "EntryName", "value": "HIPP4/7/8/17/18/19"}]}, {"database": "InterPro", "id": "IPR006121", "properties": [{"key": "EntryName", "value": "HMA_dom"}]}, {"database": "InterPro", "id": "IPR036163", "properties": [{"key": "EntryName", "value": "HMA_dom_sf"}]}, {"database": "InterPro", "id": "IPR033897", "properties": [{"key": "EntryName", "value": "SRF-like_MADS-box"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR46195:SF12", "properties": [{"key": "EntryName", "value": "HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46195", "properties": [{"key": "EntryName", "value": "HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 7"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00403", "properties": [{"key": "EntryName", "value": "HMA"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55008", "properties": [{"key": "EntryName", "value": "HMA, heavy metal-associated domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50846", "properties": [{"key": "EntryName", "value": "HMA_2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTRKKVKLAYISNGAIRKATFKKRKKGLLKKLNELSILCGIEASAIIYSPYESNPEAWPSPIAVQTTVERLRKMPETDQSKNMVTQVSFLKTRIKQVHVQLKKQHMENREKEIRQVMYKCLIGDGLLQNLGPTDLSDLGCLVDKRGLSKMAAKEEIKVKEQQKTEKGKDEKDDGVINAVYKVNLHCDQCAREIKKPLLRTQGVQNVEADLEKGEIKAKGIFDPKKIQEKIEKLTKKKIELISPKVQIKEIATTEKKVQITKQKQAISRTIPVKVHMHCEKCEKDLERKLLRHKGIHGVKADMKSQTLNVDGTIEPEKLISFLRRKVHKNAELITPKLDKKEEKKEKGDTSKPSDNKEKETSIEKTEKIVEIREEVKIVEGNAPPYFIHYVYAPQLFSDENPNACSIM", "length": 407, "molWeight": 46566, "crc64": "7A15B284E3F7E0FD", "md5": "CCE9FC2F18D728328960272963306ED3"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 3, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D29764"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTP2", "uniProtkbId": "A0AAT9UTP2_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41672.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41672.1"}], "value": "Cytochrome P450 3637B1"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003690"}], "value": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides"}], "commentType": "FUNCTION"}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 5, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 428, "modifier": "EXACT"}, "end": {"value": 428, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41672.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117232", "properties": [{"key": "ProteinId", "value": "WIM41672.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000238", "properties": [{"key": "EntryName", "value": "Cytochrome P450 2A6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050182", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_fam2"}]}, {"database": "PANTHER", "id": "PTHR24300", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 508A4-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTSEIIFFLIVILWTLIFIHFFKNCIRPKNFPNGPLLLPIIGSAWTIPGKGMEYLIPKWKKKYGNIIGHKLCNEKLVVLCESEDIIEGLKHPNFQGRFHSKFLMQRTRNKPLGFFFGDDETWSEVRRFTLRYLGVIFNTHLETILHDELLQEFSVIRNGEIHEINGMFMKTPLNVILRIMTGTRRKDYSHQIDDLQKKTEKAFMIGRVTGIELVYPLLKRLFHNDVQIDAINATHKFLKDRLEEHRKSFDPLDIKDYTDAFINESEKEIELYGKINHFTDDEFLSCGIDLLQAGNESTGKTIQFIFMYVAMNEEIQNKLHNEIDEIIGKERYPELSDRINMPYLEATIYEGMRINPIAPIGVAHRVTENTNFKGYFFEKDTLIIFALKYAMHDPEKWQNPDEFMPERFINSDRSKKKIPNFGLGKRSCIGEVLVKNFMFIYLAHFFQKYSIKLPHGYKPCTIPILGITNGPQPFKLVITERKNVTL", "length": 486, "molWeight": 56916, "crc64": "D1B6D37338D29295", "md5": "36F3A4D689F1C3AD9546D9EB9FCEECF8"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D3C239"}, "cluster_size": 6, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9FG62", "uniProtkbId": "A0AAT9FG62_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Enchytraeus japonensis", "taxonId": 228735, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61263.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61263.1"}], "value": "ATP-dependent RNA helicase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61263.1"}], "value": "Ej-pl10"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61263.1"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61263.1"}], "id": "KW-0347", "category": "Molecular function", "name": "Helicase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61263.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61263.1"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1NS4NNSF9REKQ", "citationType": "submission", "authors": ["Yamaguchi S.", "Fujita T."], "title": "Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61263.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC727636", "properties": [{"key": "ProteinId", "value": "BDR61263.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004386", "properties": [{"key": "GoTerm", "value": "F:helicase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "PANTHER", "id": "PTHR47958", "properties": [{"key": "EntryName", "value": "ATP-DEPENDENT RNA HELICASE DBP3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPGCIEEYVHRIGRTGRVGNLGLATSFFNDKNKPITKDLVELLVESHQDVPKWLEEQAYRTPHPTGSYKRPPGKRFNTTFASRDYRQHPQHPQPGLQQHMIPTNPAALQAQVQAPTQYNPQAMQGGLARAPQQHAVMYNPQQSQAAPQQAAQAGYILGGYGYPTYPQAAMGQGAEWWTGGYGGN", "length": 184, "molWeight": 20354, "crc64": "A52D2CE0DE92ED33", "md5": "E0EBCD83B08FB2640B4C2C9E0AD1CEF4"}, "extraAttributes": {"uniParcId": "UPI0035D39F97"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0E3", "uniProtkbId": "A0AA96S0E3_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50060.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50060.1"}], "value": "NUFP1 protein"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 153, "modifier": "EXACT"}, "end": {"value": 175, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Region", "location": {"start": {"value": 222, "modifier": "EXACT"}, "end": {"value": 347, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 390, "modifier": "EXACT"}, "end": {"value": 477, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 541, "modifier": "EXACT"}, "end": {"value": 582, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 222, "modifier": "EXACT"}, "end": {"value": 251, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 268, "modifier": "EXACT"}, "end": {"value": 292, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 293, "modifier": "EXACT"}, "end": {"value": 314, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 424, "modifier": "EXACT"}, "end": {"value": 458, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 459, "modifier": "EXACT"}, "end": {"value": 477, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 549, "modifier": "EXACT"}, "end": {"value": 558, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 559, "modifier": "EXACT"}, "end": {"value": 582, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00042"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00042"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00042"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50060.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460137", "properties": [{"key": "ProteinId", "value": "WNS50060.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0000492", "properties": [{"key": "GoTerm", "value": "P:box C/D snoRNP assembly"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR039136", "properties": [{"key": "EntryName", "value": "NUFIP1-like"}]}, {"database": "InterPro", "id": "IPR019496", "properties": [{"key": "EntryName", "value": "NUFIP1_cons_dom"}]}, {"database": "InterPro", "id": "IPR013087", "properties": [{"key": "EntryName", "value": "Znf_C2H2_type"}]}, {"database": "PANTHER", "id": "PTHR13309:SF0", "properties": [{"key": "EntryName", "value": "FMR1-INTERACTING PROTEIN NUFIP1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13309", "properties": [{"key": "EntryName", "value": "NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10453", "properties": [{"key": "EntryName", "value": "NUFIP1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00355", "properties": [{"key": "EntryName", "value": "ZnF_C2H2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS00028", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50157", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLPFIPPPMTPQNAGPNPLAHLVMPTLNGQPPPMPMMGMPPPNISLQGMPPLGILLPGMPPPSHMQWRQGLPENFPPGQFAPGQQLFQHQPRWPLFPPPLQPPLGWPAPGLPAPPPTGARYPAHMKRHHSAQWKPDSKKPKIRDEASEDVGEFSCENCSRSYTERIHYDNHLRSHKKCMHPGCDFEAIHKVLNDHSLVHSISKELLFDSPDEIAKWREERKKKFPTKDAVEKKLAEQSERRRRGEVVEKRSTKYTGQGFHNECSNSRGRGRGRGRGRGFRGRGRGSHGRGRNRQSDHDCCDQTHQPAGEDREIDTSQGPSDVKLECGGSTDSSYRGGVDRDRSEVVQINDDTIVGGVTDESGCRSQAISRVVADVTERCGVFGSEQGENEIPCLSKASSSVPGDLNLGNGLNESATESDRAIPSTENSKPFPQSPFQRNETHCSDIQPQSTAEHLSNTVPARSPSEEVSSSEQQSAVSTIATIPTATQVQTAPSSVCTGTPVSLSEETALSHHSETIPLISSSNAPVSLSEEASHTALAGVSPVAPPQRSLQGRSNHPSSSQSATAKSSQFSRSNAKQPKQSLLQKLLAPQIQSDRNKLLQCVRFIVENNFLDKPQLKST", "length": 620, "molWeight": 67712, "crc64": "EBD62552FE8A5222", "md5": "D41E35F9E230E8A423FE8A5D260E9422"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 3, "Compositional bias": 7}, "uniParcId": "UPI002B304298"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6ND40", "uniProtkbId": "A0AAU6ND40_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59752.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59752.1"}], "value": "CSP3"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 71, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043873454"}, {"type": "Non-terminal residue", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 71, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59752.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59752.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420112", "properties": [{"key": "ProteinId", "value": "WWA59752.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.2080.10", "properties": [{"key": "EntryName", "value": "Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005055", "properties": [{"key": "EntryName", "value": "A10/PebIII"}]}, {"database": "InterPro", "id": "IPR036682", "properties": [{"key": "EntryName", "value": "OS_D_A10/PebIII_sf"}]}, {"database": "PANTHER", "id": "PTHR11257", "properties": [{"key": "EntryName", "value": "CHEMOSENSORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11257:SF13", "properties": [{"key": "EntryName", "value": "GEO07322P1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03392", "properties": [{"key": "EntryName", "value": "OS-D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF100910", "properties": [{"key": "EntryName", "value": "Chemosensory protein Csp2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKADCLLLATLIVVVVADFYDSKYDSFDVQPLLENDRILLSYTKCFLDEGPCTPDAKDFKSKFHNIKFKFN", "length": 71, "molWeight": 8200, "crc64": "B2789FFBF9DDFFAE", "md5": "617E28A36E3498DACCBBBFA973A915AC"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D2769E"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0E1", "uniProtkbId": "A0AA96S0E1_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50045.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50045.1"}], "value": "Glycoside hydrolase/deacetylase, beta/alpha-barrel-like protein"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 489, "modifier": "EXACT"}, "end": {"value": 516, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 2, "modifier": "EXACT"}, "end": {"value": 128, "modifier": "EXACT"}}, "description": "NodB homology", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01522"}]}, {"type": "Region", "location": {"start": {"value": 363, "modifier": "EXACT"}, "end": {"value": 424, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 521, "modifier": "EXACT"}, "end": {"value": 552, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 363, "modifier": "EXACT"}, "end": {"value": 403, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 411, "modifier": "EXACT"}, "end": {"value": 424, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 521, "modifier": "EXACT"}, "end": {"value": 531, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 532, "modifier": "EXACT"}, "end": {"value": 552, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50045.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50045.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460122", "properties": [{"key": "ProteinId", "value": "WNS50045.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016810", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.20.20.370", "properties": [{"key": "EntryName", "value": "Glycoside hydrolase/deacetylase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR052740", "properties": [{"key": "EntryName", "value": "CE4"}]}, {"database": "InterPro", "id": "IPR011330", "properties": [{"key": "EntryName", "value": "Glyco_hydro/deAcase_b/a-brl"}]}, {"database": "InterPro", "id": "IPR002509", "properties": [{"key": "EntryName", "value": "NODB_dom"}]}, {"database": "PANTHER", "id": "PTHR45985", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45985:SF3", "properties": [{"key": "EntryName", "value": "CHITIN DEACETYLASE-LIKE 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01522", "properties": [{"key": "EntryName", "value": "Polysacc_deac_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF88713", "properties": [{"key": "EntryName", "value": "Glycoside hydrolase/deacetylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVTISFDDAIRVQDYERFYTKILQGRTNPNGCKVPLTFFVSHYDTDYSLAAEIVSEGHELAVHSVTHRTPSGYWAGDDNNTNELTHEILDMRSILSQWARVPKDRVVGYRTPFLASSEDQLKILHENDFLYDCTMVTNDMYWPFTLDYKSPICNSPAVCPDSSLPGLWVIPNINKVQNSSFSCSMIDSCSHPFKTSYDHWTYFFRHNFERHYNNTKVPFGLYAHASWFYYPSMVDRLQAFIDFLDYLGSLNDVYIVTMSQLIAWSKNPTPLSQISTFKPWGCTEEPPQTDCVHTDQTLCKYSGNTNPGSDALPTDIFIRLCGSDECPTLYPNVTVPAGEYPVPSSSSVDLLTTVDLLTSTELLQPSSSSSSSSLDFTSSNSDFATSSSMKSSSVSESSSALESAETDMVISQSTSTQSDDSATADLERTATTVVLSTRNVVNVGTEPTETATVLPSASVDGGNTGPGVVDNTARGGASSSAGGGLQGGAVAGVIVGVLLVVGALATVAVVGGIVVYSRARRGRRPAAKRRAQSGAASASSSSYRNPSAQLTL", "length": 552, "molWeight": 59815, "crc64": "24FBB6EEC7C1E39C", "md5": "BFDEF95D851FC23CA30D6979B32DEDF8"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Domain": 1, "Region": 2, "Compositional bias": 4}, "uniParcId": "UPI002B27D1F2"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38YAP9", "uniProtkbId": "A0AB38YAP9_9ACAR", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39422.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39422.1"}], "value": "Beta-tubulin"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004245"}], "value": "Cytoplasm, cytoskeleton", "id": "SL-0090"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009636"}], "value": "Belongs to the tubulin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "Tubulin/FtsZ 2-layer sandwich", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00865"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39422.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 152, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39422.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023212"}], "id": "KW-0206", "category": "Cellular component", "name": "Cytoskeleton"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023134"}], "id": "KW-0342", "category": "Ligand", "name": "GTP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022701"}], "id": "KW-0493", "category": "Cellular component", "name": "Microtubule"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FCH8NLO8SBUEG", "citationType": "submission", "authors": ["Augustine N.", "Selvapandian U.", "Muthugoundar M."], "title": "Evaluation of reference genes for expression studies in the broad mite, Polyphagotarsonemus latus (Acari: Tarsonemidae).", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39422.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR134569", "properties": [{"key": "ProteinId", "value": "WIW39422.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0000930", "properties": [{"key": "GoTerm", "value": "C:gamma-tubulin complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005874", "properties": [{"key": "GoTerm", "value": "C:microtubule"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0031122", "properties": [{"key": "GoTerm", "value": "P:cytoplasmic microtubule organization"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007020", "properties": [{"key": "GoTerm", "value": "P:microtubule nucleation"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.30.1330.20", "properties": [{"key": "EntryName", "value": "Tubulin/FtsZ, C-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.1440", "properties": [{"key": "EntryName", "value": "Tubulin/FtsZ, GTPase domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002454", "properties": [{"key": "EntryName", "value": "Gamma_tubulin"}]}, {"database": "InterPro", "id": "IPR008280", "properties": [{"key": "EntryName", "value": "Tub_FtsZ_C"}]}, {"database": "InterPro", "id": "IPR000217", "properties": [{"key": "EntryName", "value": "Tubulin"}]}, {"database": "InterPro", "id": "IPR037103", "properties": [{"key": "EntryName", "value": "Tubulin/FtsZ-like_C"}]}, {"database": "InterPro", "id": "IPR018316", "properties": [{"key": "EntryName", "value": "Tubulin/FtsZ_2-layer-sand-dom"}]}, {"database": "InterPro", "id": "IPR036525", "properties": [{"key": "EntryName", "value": "Tubulin/FtsZ_GTPase_sf"}]}, {"database": "PANTHER", "id": "PTHR11588", "properties": [{"key": "EntryName", "value": "TUBULIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03953", "properties": [{"key": "EntryName", "value": "Tubulin_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01164", "properties": [{"key": "EntryName", "value": "GAMMATUBULIN"}]}, {"database": "SMART", "id": "SM00865", "properties": [{"key": "EntryName", "value": "Tubulin_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55307", "properties": [{"key": "EntryName", "value": "Tubulin C-terminal domain-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "AVERLHLENPSFTQINSLVSTIMSSSTATLRYPSYMNNDLIGLIAPLIPIPKLHFLMTGYTPLTTDQDSSIIRKTTVLDVMRRLLQPSNMMVSTNINDKSVNHCYISILNIIQGEVDPTKVHKSLQSIRERKLAQFIPWGPAGIQVDPTKVH", "length": 152, "molWeight": 17053, "crc64": "D5184A08605A9DBC", "md5": "FE01E269F8644ECB34F66ECD6A28F6AC"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI00388C1463"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLM8", "uniProtkbId": "A0AAU0QLM8_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56449.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56449.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 43, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 109, "modifier": "EXACT"}, "end": {"value": 130, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 142, "modifier": "EXACT"}, "end": {"value": 160, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56449.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56449.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56449.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970342", "properties": [{"key": "ProteinId", "value": "WPO56449.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF44", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 13A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPSSYGLPKPGSPFLVFLGMFWAQAAAGASLEIVCYFSLNALIGVNVMNIKALFIILETDLENAIEDNELVSFRLDLTDTDNVSSYKKISNIIKRHQKILRICNEINDVFSLTIFVDVTCAATAIGFYGFVLITEPDIPTKILHFFRMVSVSLTIFIYTWPAEVLSEANADLAQAAYNSLWYISDVRSRRLILLIMHRSVHPVYLKALSFWNIRLETYSKIVSSAYSYISVLSTANN", "length": 237, "molWeight": 26685, "crc64": "9E63C6110F6D4318", "md5": "71BAC79DE12BFF3CCE95EC793C8CD9C9"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 3}, "uniParcId": "UPI003091BB61"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA95ZAY3", "uniProtkbId": "A0AA95ZAY3_PSIGU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Psidium guajava", "commonName": "Guava", "synonyms": ["Psidium pyriferum"], "taxonId": 120290, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01964.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "malvids", "Myrtales", "Myrtaceae", "Myrtoideae", "Myrteae", "Pimenta group", "Psidium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01964.1"}], "value": "Terpene synthase"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 81, "modifier": "EXACT"}}, "description": "Terpene synthase N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01397"}]}, {"type": "Domain", "location": {"start": {"value": 156, "modifier": "EXACT"}, "end": {"value": 241, "modifier": "EXACT"}}, "description": "Terpene synthase metal-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03936"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022842"}], "id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FCTKIOK6O0LM0", "citationType": "submission", "authors": ["Canal D.", "dos Santos P.H.D.", "Carpinetti-Oliveira P.A.", "Silva M.A.", "Fernandes M.", "Brustolini O.J.B.", "Ferreira A.", "Ferreira M.F.S."], "title": "Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01964.1"}], "value": "Pg16969", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01964.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR232572", "properties": [{"key": "ProteinId", "value": "WNI01964.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0000287", "properties": [{"key": "GoTerm", "value": "F:magnesium ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0010333", "properties": [{"key": "GoTerm", "value": "F:terpene synthase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016114", "properties": [{"key": "GoTerm", "value": "P:terpenoid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.600.10", "properties": [{"key": "EntryName", "value": "Farnesyl Diphosphate Synthase"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "1.50.10.130", "properties": [{"key": "EntryName", "value": "Terpene synthase, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008949", "properties": [{"key": "EntryName", "value": "Isoprenoid_synthase_dom_sf"}]}, {"database": "InterPro", "id": "IPR001906", "properties": [{"key": "EntryName", "value": "Terpene_synth_N"}]}, {"database": "InterPro", "id": "IPR036965", "properties": [{"key": "EntryName", "value": "Terpene_synth_N_sf"}]}, {"database": "InterPro", "id": "IPR050148", "properties": [{"key": "EntryName", "value": "Terpene_synthase-like"}]}, {"database": "InterPro", "id": "IPR005630", "properties": [{"key": "EntryName", "value": "Terpene_synthase_metal-bd"}]}, {"database": "InterPro", "id": "IPR008930", "properties": [{"key": "EntryName", "value": "Terpenoid_cyclase/PrenylTrfase"}]}, {"database": "PANTHER", "id": "PTHR31225", "properties": [{"key": "EntryName", "value": "OS04G0344100 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31225:SF234", "properties": [{"key": "EntryName", "value": "TERPENE SYNTHASE 4-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01397", "properties": [{"key": "EntryName", "value": "Terpene_synth"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03936", "properties": [{"key": "EntryName", "value": "Terpene_synth_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48239", "properties": [{"key": "EntryName", "value": "Terpenoid cyclases/Protein prenyltransferases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48576", "properties": [{"key": "EntryName", "value": "Terpenoid synthases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MMSMRSLSIFDFFGKRVIMCLQTRCAFYADVFERFKDKINGFVEGNIKSMMELYEASQMSMEGEDILDEAEDFGGKFLNALPMCDLDHERARTIESMLRCPYRKSFRRSLEPRTFVNDMVGANSWMEDLLEVAKRERRIVHSGHRKEIHQINKWWKELGLGEETKFARDQPLKWHMWSMAILIDPRLSEPRVELIKPISLVYLIDDVFDVRGTFDELILFTEVIGRWDNAGAKQLPEDMKWANLCGAFLVEFQWNASGKLPNADDYLKNETITSGVPLVLAHLFFLMGEDIANQTMESKKEEAPLPNTVFLVAKILRLWDDRGCAQDKNQNGYDGSYVECYL", "length": 342, "molWeight": 39734, "crc64": "5F41883324E57248", "md5": "D5FAC15F8729AC9299CC2725DB9499E6"}, "extraAttributes": {"countByFeatureType": {"Domain": 2}, "uniParcId": "UPI002B3055BA"}, "cluster_size": 1, "family": "Myrtaceae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXX6", "uniProtkbId": "XTPA_ECOLI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Escherichia coli (strain K12)", "taxonId": 83333, "lineage": ["Bacteria", "Pseudomonadati", "Pseudomonadota", "Gammaproteobacteria", "Enterobacterales", "Enterobacteriaceae", "Escherichia"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "35081614"}], "value": "Putative transcriptional regulator XtpA"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "35081614"}], "value": "xtpA"}, "orderedLocusNames": [{"value": "b4845"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35081614"}, {"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "35081614"}], "value": "Controls the expression of small non-coding RNA GcvB, which represses the expression of many amino acid transporter proteins and uptake of aminoglycoside antibiotics in cells (PubMed:35081614). Might be a transcriptional activator (Probable) (PubMed:35081614). An RNA (xtr) with a tRNA-like fold possibly derived from tRNA-Arg(UCG) is encoded entirely within the protein; xtr does not have the sequence corresponding to tRNA anticodon or variable arms (PubMed:35081614). 10 synonymous codon changes in the xtr region of xtpA have the same phenotype as a deletion mutation, suggesting the mRNA secondary structure is important for function (PubMed:35081614)"}], "commentType": "FUNCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35081614"}], "value": "Increased susceptibility to sub-lethal concentrations of aminoglycoside antibiotics neomycin, kanamycin, streptomycin, spectinomycin and kasugamycin, but not non-aminoglycosides tetracycline, chloramphenicol or erythromycin. 10-fold increased transcription of gvcB"}], "commentType": "DISRUPTION PHENOTYPE"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35081614"}], "value": "This is a leaderless mRNA"}], "commentType": "MISCELLANEOUS"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "Putative transcriptional regulator XtpA", "featureId": "PRO_0000461890"}, {"type": "Mutagenesis", "location": {"start": {"value": 4, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "Increased sensitivity to aminoglycoside neomycin.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35081614"}], "alternativeSequence": {}}, {"type": "Mutagenesis", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "Increased sensitivity to aminoglycoside neomycin.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35081614"}], "alternativeSequence": {}}], "keywords": [{"id": "KW-0046", "category": "Biological process", "name": "Antibiotic resistance"}, {"id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "9278503", "citationType": "journal article", "authors": ["Blattner F.R.", "Plunkett G. III", "Bloch C.A.", "Perna N.T.", "Burland V.", "Riley M.", "Collado-Vides J.", "Glasner J.D.", "Rode C.K.", "Mayhew G.F.", "Gregor J.", "Davis N.W.", "Kirkpatrick H.A.", "Goeden M.A.", "Rose D.J.", "Mau B.", "Shao Y."], "citationCrossReferences": [{"database": "PubMed", "id": "9278503"}, {"database": "DOI", "id": "10.1126/science.277.5331.1453"}], "title": "The complete genome sequence of Escherichia coli K-12.", "publicationDate": "1997", "journal": "Science", "firstPage": "1453", "lastPage": "1462", "volume": "277"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"value": "K12 / MG1655 / ATCC 47076", "type": "STRAIN"}]}, {"referenceNumber": 2, "citation": {"id": "35081614", "citationType": "journal article", "authors": ["Muto A.", "Goto S.", "Kurita D.", "Ushida C.", "Soma A.", "Himeno H."], "citationCrossReferences": [{"database": "PubMed", "id": "35081614"}, {"database": "DOI", "id": "10.1093/jb/mvac007"}], "title": "A leaderless mRNA including tRNA-like sequence encodes a small peptide that regulates the expression of GcvB small RNA in Escherichia coli.", "publicationDate": "2022", "journal": "J. Biochem.", "firstPage": "459", "lastPage": "465", "volume": "171"}, "referencePositions": ["IDENTIFICATION", "FUNCTION", "DISRUPTION PHENOTYPE", "MUTAGENESIS OF 50-PRO--PHE-60", "MUTAGENESIS OF 4-TRP--PHE-60"], "referenceComments": [{"value": "K12 / W3110 / ATCC 27325 / DSM 5911", "type": "STRAIN"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "U00096", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP000000625", "properties": [{"key": "Component", "value": "Chromosome"}]}, {"database": "GO", "id": "GO:0046677", "properties": [{"key": "GoTerm", "value": "P:response to antibiotic"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MFVWGLFCILRIALKPDRKYAVRLISKTAISSSGRADDNQDCCMVRGSRPRWRSNFSKLF", "length": 60, "molWeight": 6969, "crc64": "B4816BF7ADACFDB9", "md5": "0C6E210C1D806C42AB07EE9EB7F09D1D"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "DISRUPTION PHENOTYPE": 1, "MISCELLANEOUS": 1}, "countByFeatureType": {"Chain": 1, "Mutagenesis": 2}, "uniParcId": "UPI00388C338B"}, "cluster_size": 69, "family": "Enterobacteriaceae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXO2", "uniProtkbId": "ORF1_ZIKVF", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013)", "commonName": "ZIKV", "taxonId": 2043570, "lineage": ["Viruses", "Riboviria", "Orthornavirae", "Kitrinoviricota", "Flasuviricetes", "Amarillovirales", "Flaviviridae", "Orthoflavivirus", "Orthoflavivirus zikaense"]}, "organismHosts": [{"scientificName": "Aedes aegypti", "commonName": "Yellowfever mosquito", "synonyms": ["Culex aegypti"], "taxonId": 7159}, {"scientificName": "Aedes albopictus", "commonName": "Asian tiger mosquito", "synonyms": ["Stegomyia albopicta"], "taxonId": 7160}, {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606}, {"scientificName": "Macaca mulatta", "commonName": "Rhesus macaque", "taxonId": 9544}], "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"value": "uORF1 protein"}}}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "39394194"}], "value": "Plays a role in the reorganization of host microtubules and intermediate filaments to form a cytoskeletal cage that surrounds the viral factories, protecting the site of viral replication. May play a role in viral infection of human cortical neurons"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "39394194"}], "value": "Host cytoplasm", "id": "SL-0381"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "39394194"}], "value": "Host cytoplasm, host cytoskeleton", "id": "SL-0383"}}]}, {"commentType": "ALTERNATIVE PRODUCTS", "events": ["Alternative initiation"], "isoforms": [{"name": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "39394194"}], "value": "uORF1 protein"}, "isoformIds": ["P0DXO2-1"], "isoformSequenceStatus": "Displayed"}, {"name": {"value": "Genome polyprotein"}, "isoformIds": ["A0A024B7W1-1"], "isoformSequenceStatus": "External"}, {"name": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "39394194"}], "value": "uORF2 protein"}, "isoformIds": ["P0DXO0-1"], "isoformSequenceStatus": "External"}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "39394194"}], "value": "Product of an upstream open reading frame of the genome polyprotein gene"}], "commentType": "MISCELLANEOUS"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "39394194"}], "value": "The initiator methionine is coded by an unusual start codon CTG"}], "commentType": "MISCELLANEOUS"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the Zika virus American lineage encoding for a two uORF"}], "commentType": "MISCELLANEOUS"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 28, "modifier": "EXACT"}}, "description": "uORF1 protein", "featureId": "PRO_0000461827"}, {"type": "Mutagenesis", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 14, "modifier": "EXACT"}}, "description": "Complete loss of granular structures in the cytoplasm.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "39394194"}], "alternativeSequence": {"originalSequence": "I", "alternativeSequences": ["P"]}}], "keywords": [{"id": "KW-0024", "category": "Coding sequence diversity", "name": "Alternative initiation"}, {"id": "KW-1035", "category": "Cellular component", "name": "Host cytoplasm"}, {"id": "KW-1037", "category": "Cellular component", "name": "Host cytoskeleton"}], "references": [{"referenceNumber": 1, "citation": {"id": "24903869", "citationType": "journal article", "authors": ["Baronti C.", "Piorkowski G.", "Charrel R.N.", "Boubis L.", "Leparc-Goffart I.", "de Lamballerie X."], "citationCrossReferences": [{"database": "PubMed", "id": "24903869"}, {"database": "DOI", "id": "10.1128/genomea.00500-14"}], "title": "Complete coding sequence of zika virus from a French polynesia outbreak in 2013.", "publicationDate": "2014", "journal": "Genome Announc.", "firstPage": "0", "lastPage": "0", "volume": "2"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}, {"referenceNumber": 2, "citation": {"id": "39394194", "citationType": "journal article", "authors": ["Lefevre C.", "Cook G.M.", "Dinan A.M.", "Torii S.", "Stewart H.", "Gibbons G.", "Nicholson A.S.", "Echavarria-Consuegra L.", "Meredith L.W.", "Lulla V.", "McGovern N.", "Kenyon J.C.", "Goodfellow I.", "Deane J.E.", "Graham S.C.", "Lakatos A.", "Lambrechts L.", "Brierley I.", "Irigoyen N."], "citationCrossReferences": [{"database": "PubMed", "id": "39394194"}, {"database": "DOI", "id": "10.1038/s41467-024-53085-9"}], "title": "Zika viruses encode 5' upstream open reading frames affecting infection of human brain cells.", "publicationDate": "2024", "journal": "Nat. Commun.", "firstPage": "8822", "lastPage": "8822", "volume": "15"}, "referencePositions": ["ALTERNATIVE INITIATION (ISOFORM UROF1 AND UORF2)", "FUNCTION", "SUBCELLULAR LOCATION", "MUTAGENESIS OF ILE-14"], "referenceComments": [{"value": "Isolate PE243", "type": "STRAIN"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "KJ776791", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_RNA"}]}, {"database": "Proteomes", "id": "UP000151151", "properties": [{"key": "Component", "value": "Segment"}]}, {"database": "GO", "id": "GO:0030430", "properties": [{"key": "GoTerm", "value": "C:host cell cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0044163", "properties": [{"key": "GoTerm", "value": "C:host cytoskeleton"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}], "sequence": {"value": "MRQFEFEAKASNSINRFYFGFGNESFWS", "length": 28, "molWeight": 3398, "crc64": "366E5C3EE9288CD5", "md5": "6A364310AE48415C1F8CBE51840815B7"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "ALTERNATIVE PRODUCTS": 3, "MISCELLANEOUS": 3}, "countByFeatureType": {"Chain": 1, "Mutagenesis": 1}, "uniParcId": "UPI00388C33A4"}, "cluster_size": 2, "family": "Flaviviridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHJ5", "uniProtkbId": "A0AAQ5BHJ5_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519403.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519403.1"}], "value": "SMAD family member 3"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519403.1"}], "value": "SMAD3"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 31, "modifier": "EXACT"}}, "description": "MH1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51075"}]}, {"type": "Region", "location": {"start": {"value": 46, "modifier": "EXACT"}, "end": {"value": 80, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 55, "modifier": "EXACT"}, "end": {"value": 72, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHJ5"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHJ5"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519403.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519403.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16572171", "citationType": "journal article", "authors": ["Zody M.C.", "Garber M.", "Sharpe T.", "Young S.K.", "Rowen L.", "O'Neill K.", "Whittaker C.A.", "Kamal M.", "Chang J.L.", "Cuomo C.A.", "Dewar K.", "FitzGerald M.G.", "Kodira C.D.", "Madan A.", "Qin S.", "Yang X.", "Abbasi N.", "Abouelleil A.", "Arachchi H.M.", "Baradarani L.", "Birditt B.", "Bloom S.", "Bloom T.", "Borowsky M.L.", "Burke J.", "Butler J.", "Cook A.", "DeArellano K.", "DeCaprio D.", "Dorris L.III.", "Dors M.", "Eichler E.E.", "Engels R.", "Fahey J.", "Fleetwood P.", "Friedman C.", "Gearin G.", "Hall J.L.", "Hensley G.", "Johnson E.", "Jones C.", "Kamat A.", "Kaur A.", "Locke D.P.", "Madan A.", "Munson G.", "Jaffe D.B.", "Lui A.", "Macdonald P.", "Mauceli E.", "Naylor J.W.", "Nesbitt R.", "Nicol R.", "O'Leary S.B.", "Ratcliffe A.", "Rounsley S.", "She X.", "Sneddon K.M.", "Stewart S.", "Sougnez C.", "Stone S.M.", "Topham K.", "Vincent D.", "Wang S.", "Zimmer A.R.", "Birren B.W.", "Hood L.", "Lander E.S.", "Nusbaum C."], "citationCrossReferences": [{"database": "PubMed", "id": "16572171"}, {"database": "DOI", "id": "10.1038/nature04601"}], "title": "Analysis of the DNA sequence and duplication history of human chromosome 15.", "publicationDate": "2006", "journal": "Nature", "firstPage": "671", "lastPage": "675", "volume": "440"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519403.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519403.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC012568", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AC087482", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHJ5", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714111.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519403.1"}, {"key": "GeneId", "value": "ENSG00000166949.18"}]}, {"database": "HGNC", "id": "HGNC:6769", "properties": [{"key": "GeneName", "value": "SMAD3"}]}, {"database": "OpenTargets", "id": "ENSG00000166949", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000153499", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 15"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005667", "properties": [{"key": "GoTerm", "value": "C:transcription regulator complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006355", "properties": [{"key": "GoTerm", "value": "P:regulation of DNA-templated transcription"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.90.520.10:FF:000004", "properties": [{"key": "EntryName", "value": "Mothers against decapentaplegic homolog"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.90.520.10", "properties": [{"key": "EntryName", "value": "SMAD MH1 domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR013790", "properties": [{"key": "EntryName", "value": "Dwarfin"}]}, {"database": "InterPro", "id": "IPR003619", "properties": [{"key": "EntryName", "value": "MAD_homology1_Dwarfin-type"}]}, {"database": "InterPro", "id": "IPR013019", "properties": [{"key": "EntryName", "value": "MAD_homology_MH1"}]}, {"database": "InterPro", "id": "IPR036578", "properties": [{"key": "EntryName", "value": "SMAD_MH1_sf"}]}, {"database": "PANTHER", "id": "PTHR13703:SF53", "properties": [{"key": "EntryName", "value": "MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13703", "properties": [{"key": "EntryName", "value": "SMAD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03165", "properties": [{"key": "EntryName", "value": "MH1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56366", "properties": [{"key": "EntryName", "value": "SMAD MH1 domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51075", "properties": [{"key": "EntryName", "value": "MH1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPDPTPWLPE", "length": 80, "molWeight": 9186, "crc64": "E0690DF86932FB51", "md5": "8A6350F645C3C2E9DAA42208DF5EDC73"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0032CA05EE"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8HXP8", "uniProtkbId": "A0AAU8HXP8_9TELE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Astyanax altiparanae", "taxonId": 142828, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71665.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Characiformes", "Characoidei", "Acestrorhamphidae", "Acestrorhamphinae", "Astyanax"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00019844"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "value": "Cholesterol side-chain cleavage enzyme, mitochondrial"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012764"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "value": "1.14.15.6"}]}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "value": "Cholesterol desmolase"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71665.1"}], "value": "cyp11a2"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "value": "A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:35739"}, {"database": "Rhea", "id": "RHEA-COMP:9998"}, {"database": "Rhea", "id": "RHEA-COMP:9999"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:15379"}, {"database": "ChEBI", "id": "CHEBI:16113"}, {"database": "ChEBI", "id": "CHEBI:16581"}, {"database": "ChEBI", "id": "CHEBI:17998"}, {"database": "ChEBI", "id": "CHEBI:33737"}, {"database": "ChEBI", "id": "CHEBI:33738"}], "ecNumber": "1.14.15.6", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}]}}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005108"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "value": "Lipid metabolism; C21-steroid hormone metabolism"}], "commentType": "PATHWAY"}, {"commentType": "SUBCELLULAR LOCATION", "note": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "value": "Localizes to the matrix side of the mitochondrion inner membrane"}]}, "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "value": "Mitochondrion inner membrane", "id": "SL-0168"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71665.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 78, "modifier": "EXACT"}, "end": {"value": 78, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71665.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022548"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0153", "category": "Biological process", "name": "Cholesterol metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023098"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0443", "category": "Biological process", "name": "Lipid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023128"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0496", "category": "Cellular component", "name": "Mitochondrion"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022792"}], "id": "KW-0999", "category": "Cellular component", "name": "Mitochondrion inner membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023221"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0753", "category": "Biological process", "name": "Steroid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023250"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0755", "category": "Biological process", "name": "Steroidogenesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023166"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-1207", "category": "Biological process", "name": "Sterol metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022946"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU364077"}], "id": "KW-0809", "category": "Domain", "name": "Transit peptide"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8QAMRIAJBPKUI", "citationType": "submission", "authors": ["Abreu M.R.", "Batlouni S.R."], "title": "Molecular and hormonal mechanisms underlying oocyte maturation and ovulation and its application to seed production in the lambari (Astyanax altiparanae).", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71665.1"}], "value": "Ovary", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71665.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP964783", "properties": [{"key": "ProteinId", "value": "XCI71665.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005743", "properties": [{"key": "GoTerm", "value": "C:mitochondrial inner membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006700", "properties": [{"key": "GoTerm", "value": "P:C21-steroid hormone biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071375", "properties": [{"key": "GoTerm", "value": "P:cellular response to peptide hormone stimulus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008203", "properties": [{"key": "GoTerm", "value": "P:cholesterol metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0034650", "properties": [{"key": "GoTerm", "value": "P:cortisol metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006704", "properties": [{"key": "GoTerm", "value": "P:glucocorticoid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050479", "properties": [{"key": "EntryName", "value": "CYP11_CYP27_families"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "PANTHER", "id": "PTHR24279:SF3", "properties": [{"key": "EntryName", "value": "CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24279", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "DLQEELRAEITAARAASQGDTVQMLKMVPLVKGALKETLRLHPVAVSLQRYTSEDIVIQNYHIPSGTLVQLGLYAMGR", "length": 78, "molWeight": 8605, "crc64": "CF30EAB4B595B116", "md5": "355BE7535CC4C81342701C6B1425017B"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 1, "COFACTOR": 1, "PATHWAY": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D374E4"}, "cluster_size": 1, "family": "Acestrorhamphidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI61", "uniProtkbId": "A0AA96MI61_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50101.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50101.1"}], "value": "Uncharacterized protein 26"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 43, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 72, "modifier": "EXACT"}, "end": {"value": 101, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 87, "modifier": "EXACT"}, "end": {"value": 101, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50101.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460178", "properties": [{"key": "ProteinId", "value": "WNS50101.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MISPHEDNPEILLEAVTALSVALVLVLCALCLLISCIVCCLCYGCRRRVTCCQATLLWACIEFFMRPCSPLPSGSSNRNNNEEEEGNSNNNGNSSRSGRSNPYGQTMVDSSQCHNHPRAATAVHFTARGGSTGEVNSCTDGDRVHVVSNDECVKVLLCSGDDTHQCSPPPAYPV", "length": 174, "molWeight": 18691, "crc64": "B59F213555AE8952", "md5": "4C591B7240475147DEF024A61068FC33"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B2A5875"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEC4", "uniProtkbId": "A0AB38ZEC4_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71768.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71768.1"}], "value": "Venom S1 protease 33"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 143, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 143, "modifier": "EXACT"}, "end": {"value": 143, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71768.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71768.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71768.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71768.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510843", "properties": [{"key": "ProteinId", "value": "WXH71768.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001314", "properties": [{"key": "EntryName", "value": "Peptidase_S1A"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24253", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEASE SERINE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24253:SF103", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEASE SERINE 7"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00722", "properties": [{"key": "EntryName", "value": "CHYMOTRYPSIN"}]}, {"database": "SMART", "id": "SM00020", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKPHDMLVVMGTNDRTDSRISSGAKKILVHNYDTSNHQHDIALIELEKKITYTETVGPVCLPTTPPAKLNNQHVTAMGWGSMDKSEEGKKDGKLQKKTTLRVIDIESCSIDWNYHWEITDPNVICTWGKNTDICAGDSGGPVV", "length": 143, "molWeight": 15864, "crc64": "7DA5D4CA2DC370ED", "md5": "E2CEF9E282F3C16D7C63D7E1846E7B40"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388BDAB4"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU53", "uniProtkbId": "A0AAT9UU53_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41659.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41659.1"}], "value": "Cytochrome P450 380H1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 41, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41659.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117219", "properties": [{"key": "ProteinId", "value": "WIM41659.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEKSFGVDHLLYSVLLSFNHDKQIFTFLCFGVILSVLSYYINYKMKRRRMETIMNRYDGPATLPFIGNATEFLGSTRDLLKKAIKLMKEYKSPFRVWLVNKPYVVISTPEDFQTVAFKTLEKDSSYRFVVDMLGDGIFTSQVEKWKRNRRVINPAFNPAILFHYFLQIFNERNIDLIHRLGKEVSTGKQFDLWPHVIQTSITTICETAMGYKDDNNTEEVMNFGNAIMKSAELVGQRFYKPWLMPSFVFTAYRYLLGYGNVFSIVHNLPLKMLKKRRELFRQIKTENYVGNEQEKTMRNFIDILLNFHEINANFTDKELSDEVISIMFGGSETNAVTNCFCMLMLGMRRDIQDKVY", "length": 356, "molWeight": 41779, "crc64": "90209DA2F21A058C", "md5": "326806653077411995BA47FB8A131D13"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI0035D33FC0"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96C7I8", "uniProtkbId": "A0AA96C7I8_PSIGU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Psidium guajava", "commonName": "Guava", "synonyms": ["Psidium pyriferum"], "taxonId": 120290, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01943.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "malvids", "Myrtales", "Myrtaceae", "Myrtoideae", "Myrteae", "Pimenta group", "Psidium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01943.1"}], "value": "Terpene synthase"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 86, "modifier": "EXACT"}, "end": {"value": 144, "modifier": "EXACT"}}, "description": "Terpene synthase N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01397"}]}, {"type": "Domain", "location": {"start": {"value": 197, "modifier": "EXACT"}, "end": {"value": 250, "modifier": "EXACT"}}, "description": "Terpene synthase metal-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03936"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022842"}], "id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FCTKIOK6O0LM0", "citationType": "submission", "authors": ["Canal D.", "dos Santos P.H.D.", "Carpinetti-Oliveira P.A.", "Silva M.A.", "Fernandes M.", "Brustolini O.J.B.", "Ferreira A.", "Ferreira M.F.S."], "title": "Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01943.1"}], "value": "Pg55158", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01943.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR232551", "properties": [{"key": "ProteinId", "value": "WNI01943.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0000287", "properties": [{"key": "GoTerm", "value": "F:magnesium ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0010333", "properties": [{"key": "GoTerm", "value": "F:terpene synthase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016114", "properties": [{"key": "GoTerm", "value": "P:terpenoid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.600.10", "properties": [{"key": "EntryName", "value": "Farnesyl Diphosphate Synthase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.50.10.130", "properties": [{"key": "EntryName", "value": "Terpene synthase, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008949", "properties": [{"key": "EntryName", "value": "Isoprenoid_synthase_dom_sf"}]}, {"database": "InterPro", "id": "IPR001906", "properties": [{"key": "EntryName", "value": "Terpene_synth_N"}]}, {"database": "InterPro", "id": "IPR036965", "properties": [{"key": "EntryName", "value": "Terpene_synth_N_sf"}]}, {"database": "InterPro", "id": "IPR050148", "properties": [{"key": "EntryName", "value": "Terpene_synthase-like"}]}, {"database": "InterPro", "id": "IPR005630", "properties": [{"key": "EntryName", "value": "Terpene_synthase_metal-bd"}]}, {"database": "InterPro", "id": "IPR008930", "properties": [{"key": "EntryName", "value": "Terpenoid_cyclase/PrenylTrfase"}]}, {"database": "PANTHER", "id": "PTHR31225", "properties": [{"key": "EntryName", "value": "OS04G0344100 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31225:SF241", "properties": [{"key": "EntryName", "value": "TERPENE SYNTHASE FAMILY, METAL-BINDING DOMAIN PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01397", "properties": [{"key": "EntryName", "value": "Terpene_synth"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03936", "properties": [{"key": "EntryName", "value": "Terpene_synth_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48239", "properties": [{"key": "EntryName", "value": "Terpenoid cyclases/Protein prenyltransferases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48576", "properties": [{"key": "EntryName", "value": "Terpenoid synthases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKKQVFDVLQRSGSLSLDFSLRRGLTSANKALKTVGNMSFQVSAVPSSSPSKGRRDGVVERRLAEYHESVWGDYFLKYASPSNSTDGEGNFSKLLTTNTQGLLSLFEACHLSHLSDNILGDALAFTTTHLKSIDKTNVNPNLVKQPIHKGMPRLEARRYIQLYQEEPSHNEVLLSFAKLDFNLIQEQLQKELGHLTDVKRKFPFARNRLVAMYLWMLGAYFEPEYQVAREILTKGVYVISIIDDIYDVYVPWKNYNSSQSN", "length": 261, "molWeight": 29718, "crc64": "C66940E3872C2843", "md5": "652060B2D106CA2360EB328C49E961AD"}, "extraAttributes": {"countByFeatureType": {"Domain": 2}, "uniParcId": "UPI002B2D783B"}, "cluster_size": 1, "family": "Myrtaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96USJ2", "uniProtkbId": "A0AA96USJ2_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29084.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29084.1"}], "value": "VWACP-1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 435, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041737561"}, {"type": "Domain", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 217, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 236, "modifier": "EXACT"}, "end": {"value": 412, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29084.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651421", "properties": [{"key": "ProteinId", "value": "WNX29084.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF20", "properties": [{"key": "EntryName", "value": "PH DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00453", "properties": [{"key": "EntryName", "value": "VWFADOMAIN"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MLKQVIVLAIVMVMIADADRLSRLRGDQEKDDDCNQRCESEPLELSFVVDGSASIWPENFTYALNFIEDFMDGFDISQNAVRTSMVTYGDIVYTQDAFGFNAYSDKESLKQAISAIPYRSGVKTNTSGGIWYMLHEQRPEARSGVRHVVIVLTDGNSQEADLTRQAAHDAASEGLEVFSIGVGHQVSFAELHNIASDNDYVFEVSNYNMLEHIKDRLKYKACGNVPAPPCKMDPMDLSFVIDSSISIGEGNFSIGMKFVNDFVDNFQINPHTVRVSAITFGDQIYLQDAFDFDDFSNKKELMDRLSAIQWQHGKATNTGAGIHYMRALQMSKRRPNAAHVCIVITDGESQDGEKTVHEARQAQQQGIVMYAVGVGQIGKQLNEQELFSIAGSPQRVLSANSYQQLNLLKKQLIKKTCEGVVAALHRNAEPFRLRE", "length": 435, "molWeight": 48559, "crc64": "948AB609225CBC91", "md5": "97E05ED902B9F77D8478E1D978652FC9"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2}, "uniParcId": "UPI002B2C3B9A"}, "cluster_size": 2, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LW16", "uniProtkbId": "A0AAN0LW16_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34108.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34108.1"}], "value": "Tyrotropin-releasing hormone"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 57, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 109, "modifier": "EXACT"}, "end": {"value": 129, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 150, "modifier": "EXACT"}, "end": {"value": 172, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 199, "modifier": "EXACT"}, "end": {"value": 223, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 247, "modifier": "EXACT"}, "end": {"value": 273, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 293, "modifier": "EXACT"}, "end": {"value": 313, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 48, "modifier": "EXACT"}, "end": {"value": 310, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34108.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155034", "properties": [{"key": "ProteinId", "value": "WRW34108.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24243", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24243:SF233", "properties": [{"key": "EntryName", "value": "THYROTROPIN-RELEASING HORMONE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SMART", "id": "SM01381", "properties": [{"key": "EntryName", "value": "7TM_GPCR_Srsx"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTITKLMNSSSTLALLSSASNVTYEYPSYIRNTATVICIIIFIFGTLGNVLVSLIIIRSKELRNTTNYFLINLSIADLLVIIVCMPTVLIELHSKPEIWLLGEFMCKTIPYVEMSVAHGSILTMLAISFERYYAICKPLKVSYKCTKFRAILIILGIWIIALIATLPLLFIAKQSSAQYLDETQVEVCLTQANDAWSKAFFLIIITLFFFLPLMVLVIIYVAITKKLCAKENISYAETIQMRARKQVVVMLATVILCFFICLLPFRLFTLWLLFSSSQALDSIGMEAYYCYLFASRVMLYLNSALNPVLYNLISSKFRNAFVQILCCRKISNSSRYLFRQSTINTTTTAMSLGTNVIYNSSMTTDDKKYKRNSCFVGSLKQMNLTNLNPNQLKYQLKGRQSSLQQFPTTNKTNLKPLDCKIFEKSICINSIDNNLDENSNDKKKNSLKKVLYKDKKKNDKSVSNSTAETIID", "length": 472, "molWeight": 53650, "crc64": "5758BB3F7A3E1A49", "md5": "8EFA32DFFC74E58097203B44D6600926"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI0032498D57"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEQ6", "uniProtkbId": "A0AB38ZEQ6_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02747.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02747.1"}], "value": "Venom pacifastin 2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00029459"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}], "value": "Belongs to the protease inhibitor I19 family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044233759"}, {"type": "Domain", "location": {"start": {"value": 94, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "Pacifastin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51446"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 97, "modifier": "EXACT"}, "end": {"value": 112, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 107, "modifier": "EXACT"}, "end": {"value": 125, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 110, "modifier": "EXACT"}, "end": {"value": 120, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022690"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}], "id": "KW-0646", "category": "Molecular function", "name": "Protease inhibitor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022900"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00776"}], "id": "KW-0722", "category": "Molecular function", "name": "Serine protease inhibitor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02747.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517497", "properties": [{"key": "ProteinId", "value": "WXI02747.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004867", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "Gene3D", "id": "2.10.70.10", "properties": [{"key": "EntryName", "value": "Complement Module, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008037", "properties": [{"key": "EntryName", "value": "Pacifastin_dom"}]}, {"database": "InterPro", "id": "IPR036201", "properties": [{"key": "EntryName", "value": "Pacifastin_dom_sf"}]}, {"database": "InterPro", "id": "IPR001007", "properties": [{"key": "EntryName", "value": "VWF_dom"}]}, {"database": "Pfam", "id": "PF05375", "properties": [{"key": "EntryName", "value": "Pacifastin_I"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SMART", "id": "SM00215", "properties": [{"key": "EntryName", "value": "VWC_out"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57603", "properties": [{"key": "EntryName", "value": "FnI-like domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF57283", "properties": [{"key": "EntryName", "value": "PMP inhibitors"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51446", "properties": [{"key": "EntryName", "value": "PACIFASTIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKVAIFFALAAVFVAAEACKDGERFMAPDGCNKCVCIKGKAACTKMWCPPRKSLRCKNGETFIASDGCNKCKCIGGKAACTKMRCPPKKVKRDAEECEPDTVWKKDCNVCLCTDEGTAVCTTMECF", "length": 126, "molWeight": 13714, "crc64": "4F03343E56953CF4", "md5": "BFCA9A753749EBC63E1136D4C3A854B5"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Disulfide bond": 3}, "uniParcId": "UPI00388C23E1"}, "cluster_size": 2, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEL5", "uniProtkbId": "A0AB38ZEL5_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02706.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02706.1"}], "value": "Venom cystatin 3"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 112, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044325051"}, {"type": "Domain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 109, "modifier": "EXACT"}}, "description": "Cystatin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00043"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02706.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517456", "properties": [{"key": "ProteinId", "value": "WXI02706.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004869", "properties": [{"key": "GoTerm", "value": "F:cysteine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00042", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.450.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000010", "properties": [{"key": "EntryName", "value": "Cystatin_dom"}]}, {"database": "InterPro", "id": "IPR046350", "properties": [{"key": "EntryName", "value": "Cystatin_sf"}]}, {"database": "Pfam", "id": "PF00031", "properties": [{"key": "EntryName", "value": "Cystatin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00043", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54403", "properties": [{"key": "EntryName", "value": "Cystatin/monellin"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MALKAIFFMLATLVALHHVNASCPGCISDADVNDPNILRGVKQVLAQQNSNDMVIKIVSAKSQVVSGIRYIVEFLVKNPQTNETKLCKADYIEQPWESKNSIIKDFSCEVKN", "length": 112, "molWeight": 12438, "crc64": "87EC87692F372186", "md5": "C806F8754EF578E49B08B8E793AD02BE"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388BFAEF"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI11", "uniProtkbId": "A0AA96MI11_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50026.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50026.1"}], "value": "Uncharacterized protein 1"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 495, "modifier": "EXACT"}, "end": {"value": 606, "modifier": "EXACT"}}, "description": "PID", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS01179"}]}, {"type": "Region", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 57, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 239, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 251, "modifier": "EXACT"}, "end": {"value": 290, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 305, "modifier": "EXACT"}, "end": {"value": 327, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 355, "modifier": "EXACT"}, "end": {"value": 387, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 405, "modifier": "EXACT"}, "end": {"value": 486, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 46, "modifier": "EXACT"}, "end": {"value": 57, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 191, "modifier": "EXACT"}, "end": {"value": 206, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 223, "modifier": "EXACT"}, "end": {"value": 232, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 266, "modifier": "EXACT"}, "end": {"value": 276, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 309, "modifier": "EXACT"}, "end": {"value": 319, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 367, "modifier": "EXACT"}, "end": {"value": 377, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 405, "modifier": "EXACT"}, "end": {"value": 416, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 425, "modifier": "EXACT"}, "end": {"value": 437, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50026.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460103", "properties": [{"key": "ProteinId", "value": "WNS50026.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.30.29.30", "properties": [{"key": "EntryName", "value": "Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR011993", "properties": [{"key": "EntryName", "value": "PH-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR006020", "properties": [{"key": "EntryName", "value": "PTB/PI_dom"}]}, {"database": "SUPFAM", "id": "SSF50729", "properties": [{"key": "EntryName", "value": "PH domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01179", "properties": [{"key": "EntryName", "value": "PID"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSFSYVAEEDDSKVDYTRILAPQYDPEIVPSRKTREPDNAILQSHDGLRYRRSSEKESPRLPRKFDYAHLYFSPSSTEKPLPSLLNPDYVNLDLEEAIPTALVPDHVVFPVVKDIKGCYVNLEVSRPTEVAHRRSSSSCQLHAAPSSPPPPLHPLSRWQSERLHPSTKSITGALQPPMRDYQNIRPTSRQPSPAAGLSPAASLAVARAQSFQSPLRPWDKPSLQRNPTTGEYSHSDHDPPIEIVLEQATTRRTGRHAAAGDRGHRSGAAARSVSSVAGGGGGGSNLPRPPWGVVVRRLPLRSQSEVRSSKARLQAHRKTHILDRPAEQRRHSLMPDYQNLWYLEPESFSILEGHHTSGMRTRRRSSSTDGQGSSTEGWDSGTDERGSVCRGSVISLRSAMSSDYSFDHLQPHRPEETSPSDIITQSQVDASSQSSCSTPFDSHGNKDHFRPMSTPPTVGAHSRDDDKRRSYQQAPPPLPKRSSAKARTGKHLGLFKVQYLGQHPTNRFSGEVDHCLRKMTTSVHFAAKEVFVYVTNSVLRLTPPHSDLLFASFSVEHVLGVESSLKTESVVGIVFKRSKAKCACHVFDCKDRLTAKIFLKTVKEALVSIPEEESLRLKARAEEIERCSLLPSDLFGAVTYVGSCGISPNDVITKTIDSALSAGALRPSGLHSVVLSLRAVMDRRGGVLEVFQRESPAPLHCWHLCDVEMVGCRVADRRYIGLHLLEEEPQLHILHFGGVVGGVAFLAVLRDKFGVCIDEGEFVSPRRSPSCRVTEAGGGVPAGASGEPWRRPVSKKLSFKKLICAIAK", "length": 808, "molWeight": 89056, "crc64": "2B1C768720D73492", "md5": "3E88DAF2CA0AD19512F9D37840C9E402"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 6, "Compositional bias": 8}, "uniParcId": "UPI002B296FE9"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHX1", "uniProtkbId": "A0AAQ5BHX1_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519637.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519637.1"}], "value": "Signal transducer and activator of transcription 6"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519637.1"}], "value": "STAT6"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005586"}], "value": "Belongs to the transcription factor STAT family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 2, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "STAT transcription factor protein interaction", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00964"}]}, {"type": "Region", "location": {"start": {"value": 407, "modifier": "EXACT"}, "end": {"value": 433, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022553"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHX1"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHX1"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022999"}], "id": "KW-0727", "category": "Domain", "name": "SH2 domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519637.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519637.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16541075", "citationType": "journal article", "authoringGroup": ["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"], "authors": ["Scherer S.E.", "Muzny D.M.", "Buhay C.J.", "Chen R.", "Cree A.", "Ding Y.", "Dugan-Rocha S.", "Gill R.", "Gunaratne P.", "Harris R.A.", "Hawes A.C.", "Hernandez J.", "Hodgson A.V.", "Hume J.", "Jackson A.", "Khan Z.M.", "Kovar-Smith C.", "Lewis L.R.", "Lozado R.J.", "Metzker M.L.", "Milosavljevic A.", "Miner G.R.", "Montgomery K.T.", "Morgan M.B.", "Nazareth L.V.", "Scott G.", "Sodergren E.", "Song X.Z.", "Steffen D.", "Lovering R.C.", "Wheeler D.A.", "Worley K.C.", "Yuan Y.", "Zhang Z.", "Adams C.Q.", "Ansari-Lari M.A.", "Ayele M.", "Brown M.J.", "Chen G.", "Chen Z.", "Clerc-Blankenburg K.P.", "Davis C.", "Delgado O.", "Dinh H.H.", "Draper H.", "Gonzalez-Garay M.L.", "Havlak P.", "Jackson L.R.", "Jacob L.S.", "Kelly S.H.", "Li L.", "Li Z.", "Liu J.", "Liu W.", "Lu J.", "Maheshwari M.", "Nguyen B.V.", "Okwuonu G.O.", "Pasternak S.", "Perez L.M.", "Plopper F.J.", "Santibanez J.", "Shen H.", "Tabor P.E.", "Verduzco D.", "Waldron L.", "Wang Q.", "Williams G.A.", "Zhang J.", "Zhou J.", "Allen C.C.", "Amin A.G.", "Anyalebechi V.", "Bailey M.", "Barbaria J.A.", "Bimage K.E.", "Bryant N.P.", "Burch P.E.", "Burkett C.E.", "Burrell K.L.", "Calderon E.", "Cardenas V.", "Carter K.", "Casias K.", "Cavazos I.", "Cavazos S.R.", "Ceasar H.", "Chacko J.", "Chan S.N.", "Chavez D.", "Christopoulos C.", "Chu J.", "Cockrell R.", "Cox C.D.", "Dang M.", "Dathorne S.R.", "David R.", "Davis C.M.", "Davy-Carroll L.", "Deshazo D.R.", "Donlin J.E.", "D'Souza L.", "Eaves K.A.", "Egan A.", "Emery-Cohen A.J.", "Escotto M.", "Flagg N.", "Forbes L.D.", "Gabisi A.M.", "Garza M.", "Hamilton C.", "Henderson N.", "Hernandez O.", "Hines S.", "Hogues M.E.", "Huang M.", "Idlebird D.G.", "Johnson R.", "Jolivet A.", "Jones S.", "Kagan R.", "King L.M.", "Leal B.", "Lebow H.", "Lee S.", "LeVan J.M.", "Lewis L.C.", "London P.", "Lorensuhewa L.M.", "Loulseged H.", "Lovett D.A.", "Lucier A.", "Lucier R.L.", "Ma J.", "Madu R.C.", "Mapua P.", "Martindale A.D.", "Martinez E.", "Massey E.", "Mawhiney S.", "Meador M.G.", "Mendez S.", "Mercado C.", "Mercado I.C.", "Merritt C.E.", "Miner Z.L.", "Minja E.", "Mitchell T.", "Mohabbat F.", "Mohabbat K.", "Montgomery B.", "Moore N.", "Morris S.", "Munidasa M.", "Ngo R.N.", "Nguyen N.B.", "Nickerson E.", "Nwaokelemeh O.O.", "Nwokenkwo S.", "Obregon M.", "Oguh M.", "Oragunye N.", "Oviedo R.J.", "Parish B.J.", "Parker D.N.", "Parrish J.", "Parks K.L.", "Paul H.A.", "Payton B.A.", "Perez A.", "Perrin W.", "Pickens A.", "Primus E.L.", "Pu L.L.", "Puazo M.", "Quiles M.M.", "Quiroz J.B.", "Rabata D.", "Reeves K.", "Ruiz S.J.", "Shao H.", "Sisson I.", "Sonaike T.", "Sorelle R.P.", "Sutton A.E.", "Svatek A.F.", "Svetz L.A.", "Tamerisa K.S.", "Taylor T.R.", "Teague B.", "Thomas N.", "Thorn R.D.", "Trejos Z.Y.", "Trevino B.K.", "Ukegbu O.N.", "Urban J.B.", "Vasquez L.I.", "Vera V.A.", "Villasana D.M.", "Wang L.", "Ward-Moore S.", "Warren J.T.", "Wei X.", "White F.", "Williamson A.L.", "Wleczyk R.", "Wooden H.S.", "Wooden S.H.", "Yen J.", "Yoon L.", "Yoon V.", "Zorrilla S.E.", "Nelson D.", "Kucherlapati R.", "Weinstock G.", "Gibbs R.A.", "null."], "citationCrossReferences": [{"database": "PubMed", "id": "16541075"}, {"database": "DOI", "id": "10.1038/nature04569"}], "title": "The finished DNA sequence of human chromosome 12.", "publicationDate": "2006", "journal": "Nature", "firstPage": "346", "lastPage": "351", "volume": "440"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519637.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519637.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC023237", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHX1", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714370.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519637.1"}, {"key": "GeneId", "value": "ENSG00000166888.13"}]}, {"database": "HGNC", "id": "HGNC:11368", "properties": [{"key": "GeneName", "value": "STAT6"}]}, {"database": "OpenTargets", "id": "ENSG00000166888", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT01080000257420", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 12"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0001228", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription activator activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0019221", "properties": [{"key": "GoTerm", "value": "P:cytokine-mediated signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "CDD", "id": "cd16856", "properties": [{"key": "EntryName", "value": "STAT6_CCD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.20.1050.20:FF:000004", "properties": [{"key": "EntryName", "value": "Signal transducer and transcription activator 6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.60.40.630:FF:000003", "properties": [{"key": "EntryName", "value": "Signal transducer and transcription activator 6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1050.20", "properties": [{"key": "EntryName", "value": "STAT transcription factor, all-alpha domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.630", "properties": [{"key": "EntryName", "value": "STAT transcription factor, DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008967", "properties": [{"key": "EntryName", "value": "p53-like_TF_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR001217", "properties": [{"key": "EntryName", "value": "STAT"}]}, {"database": "InterPro", "id": "IPR036535", "properties": [{"key": "EntryName", "value": "STAT_N_sf"}]}, {"database": "InterPro", "id": "IPR013800", "properties": [{"key": "EntryName", "value": "STAT_TF_alpha"}]}, {"database": "InterPro", "id": "IPR015988", "properties": [{"key": "EntryName", "value": "STAT_TF_CC"}]}, {"database": "InterPro", "id": "IPR013801", "properties": [{"key": "EntryName", "value": "STAT_TF_DNA-bd"}]}, {"database": "InterPro", "id": "IPR012345", "properties": [{"key": "EntryName", "value": "STAT_TF_DNA-bd_N"}]}, {"database": "InterPro", "id": "IPR013799", "properties": [{"key": "EntryName", "value": "STAT_TF_prot_interaction"}]}, {"database": "PANTHER", "id": "PTHR11801", "properties": [{"key": "EntryName", "value": "SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01017", "properties": [{"key": "EntryName", "value": "STAT_alpha"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02864", "properties": [{"key": "EntryName", "value": "STAT_bind"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02865", "properties": [{"key": "EntryName", "value": "STAT_int"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00964", "properties": [{"key": "EntryName", "value": "STAT_int"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49417", "properties": [{"key": "EntryName", "value": "p53-like transcription factors"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47655", "properties": [{"key": "EntryName", "value": "STAT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48092", "properties": [{"key": "EntryName", "value": "Transcription factor STAT-4 N-domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQVNRGPALPQSGTPSPPPMPHTRALDPHLL", "length": 433, "molWeight": 47741, "crc64": "DC42FCC77B62D667", "md5": "3CE4A30827579F50F114988E82674150"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Region": 1}, "uniParcId": "UPI0032CCC981"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI46", "uniProtkbId": "A0AA96MI46_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50054.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00013777"}], "value": "PCNA-associated factor"}}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00030014"}], "value": "PCNA-associated factor of 15 kDa"}}, {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00031186"}], "value": "PCNA-clamp-associated factor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004556"}], "value": "Cytoplasm, perinuclear region", "id": "SL-0198"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "PCNA-associated factor histone-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF15715"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 138, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 9, "modifier": "EXACT"}, "end": {"value": 26, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 50, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 116, "modifier": "EXACT"}, "end": {"value": 129, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022763"}], "id": "KW-0227", "category": "Biological process", "name": "DNA damage"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023204"}], "id": "KW-0234", "category": "Biological process", "name": "DNA repair"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50054.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460131", "properties": [{"key": "ProteinId", "value": "WNS50054.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0048471", "properties": [{"key": "GoTerm", "value": "C:perinuclear region of cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003682", "properties": [{"key": "GoTerm", "value": "F:chromatin binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0051726", "properties": [{"key": "GoTerm", "value": "P:regulation of cell cycle"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0019985", "properties": [{"key": "GoTerm", "value": "P:translesion synthesis"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR040444", "properties": [{"key": "EntryName", "value": "PCNA-AF"}]}, {"database": "InterPro", "id": "IPR031444", "properties": [{"key": "EntryName", "value": "PCNA-AF_dom"}]}, {"database": "PANTHER", "id": "PTHR15679", "properties": [{"key": "EntryName", "value": "PCNA-ASSOCIATED FACTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR15679:SF8", "properties": [{"key": "EntryName", "value": "PCNA-ASSOCIATED FACTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF15715", "properties": [{"key": "EntryName", "value": "PAF"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVRTRGDCSSSSTGSSSAGRKAVVARAPRKALGGPSSSSVSCFSSSSKGGATKKGKNNSGHNAMKMWPTPAWQKELKVFLGGQSPPKKTDETGEEDASSSKDLAYETSVHGDSQGSISTSTPEPSLTESCNDEEGDSE", "length": 138, "molWeight": 14235, "crc64": "CFA4FFE60D9E5D60", "md5": "2E8279FF4051C6B90367BCE6455AA413"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 3}, "uniParcId": "UPI002B2FE53D"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7BNZ8", "uniProtkbId": "A0AAU7BNZ8_9MOLL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Xipholeptos notoides", "taxonId": 66914, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG55519.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Cephalopoda", "Coleoidea", "Decapodiformes", "Decapodiformes incertae sedis", "Idiosepiidae", "Xipholeptos"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG55519.1"}], "value": "Xenopsin"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 50, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 62, "modifier": "EXACT"}, "end": {"value": 87, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 99, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 127, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG55519.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 127, "modifier": "EXACT"}, "end": {"value": 127, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG55519.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-135FE3H0KD621", "citationType": "submission", "authors": ["Koller D.", "Kocot K.M.", "Degnan B.M.", "Wollesen T."], "title": "Developmental gene expression in the eyes of the pygmy squid Xipholeptos notoides.", "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG55519.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP836151", "properties": [{"key": "ProteinId", "value": "XBG55519.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050125", "properties": [{"key": "EntryName", "value": "GPCR_opsins"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24240", "properties": [{"key": "EntryName", "value": "OPSIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSQTMHNSLVTIRGHQENTVSREAGLIVALVLAMFSAVSFLLNGAVILLFILRKDLLTPTNVFIVTLSVCDFLIATLGNPLAIVSSAMRRWYFGRGVCVWYGFTMTFLGLSAISLLTAISVDRYVLI", "length": 127, "molWeight": 13959, "crc64": "86D837402760E755", "md5": "26DCB9D5253AE2CA9D6EB4C2383EE2F2"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 3, "Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D3426A"}, "cluster_size": 1, "family": "Idiosepiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HD43", "uniProtkbId": "A0AA96HD43_THRPL", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Thrips palmi", "commonName": "Melon thrips", "taxonId": 161013, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28509.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Thysanoptera", "Terebrantia", "Thripoidea", "Thripidae", "Thrips"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28509.1"}], "value": "Egghead"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28509.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 76, "modifier": "EXACT"}, "end": {"value": 76, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28509.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-A8QMHI7B7G5F", "citationType": "submission", "authors": ["Shiksha B.", "Amalendu G."], "publicationDate": "JUL-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28509.1"}], "value": "AG-81", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28509.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR371480", "properties": [{"key": "ProteinId", "value": "WNN28509.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0019187", "properties": [{"key": "GoTerm", "value": "F:beta-1,4-mannosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR027389", "properties": [{"key": "EntryName", "value": "B_mannosylTrfase_Bre-3/Egh"}]}, {"database": "PANTHER", "id": "PTHR16779", "properties": [{"key": "EntryName", "value": "BETA-1,4-MANNOSYLTRANSFERASE EGH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR16779:SF1", "properties": [{"key": "EntryName", "value": "BETA-1,4-MANNOSYLTRANSFERASE EGH"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "PLPQVLFCLYGLTRYNDFPMEVKLTGSPLLAPFICIRVVTRGDYKELVKNNVSRNMKHCLDAGLENFLVELVTDKP", "length": 76, "molWeight": 8655, "crc64": "874C2E52E0A99A93", "md5": "AE38509F7A6D51C98422084BD7A2FD7E"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI002B2B6EED"}, "cluster_size": 1, "family": "Thripidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P9WEG8", "uniProtkbId": "FSOF_HUMFU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Humicola fuscoatra", "taxonId": 112175, "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Pezizomycotina", "Sordariomycetes", "Sordariomycetidae", "Sordariales", "Chaetomiaceae", "Humicola"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38654452"}], "value": "Acetyltransferase fsoF"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}], "value": "2.3.1.-"}]}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38654452"}], "value": "Fuscoatroside biosynthesis cluster protein F"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38654452"}], "value": "fsoF"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}], "value": "Terpene cyclase-glycosyl transferase fusion protein; part of the gene cluster that mediates the biosynthesis of the enfumafungin-type antibiotic, fuscoatroside (PubMed:38654452). Within the pathway, fsoF catalyzes the acetylation of C2-alpha-OH following the C2 hydroxylation by the cytochrome monooxygenase fsoD (PubMed:38654452). The fuscoatroside biosynthesis is initiated by the cyclization of 2,3(S)-oxidosqualene through FsoA's terpene cyclase (TC) domain, leading to the formation of the fernane skeleton isomotiol, harboring a fernane triterpene skeleton with a C8-C9 double bond. Subsequently, C2-alpha-hydroxylation mediated by fsoD results in the production of 2-alpha-hydroxy-isomotiol, which is further acetylated by fsoF. The glycosyltransferase (GT) domain of FsoA may convert isomotiol, 2-alpha-hydroxy-isomotiol, and the acetylated derivative of 2-alpha-hydroxy-isomotiol into their corresponding glycosides 3-O-(beta-D-glucopyranosyl)-isomotiol, 3-O-(beta-D-glucopyranosyl)-2-alpha-hydroxy-isomotiol, and 3-O-(beta-D-glucopyranosyl)-2-alpha-acetoxy-isomotiol, which then undergo oxidative cleavage under the action of fsoE to form s 2-deacetoxy-fuscoatroside, 2-deacetyl-fuscoatroside, and fuscoatroside, respectively. Although hydroxylation followed by acetylation of 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside by fsoD and fsoF could not be ruled out, this process is likely to occur with difficulty due to bulky steric hindrance caused by the presence of a glycan at C3 in these compounds. Interestingly, fsoE can also utilize the aglycones isomotiol and 2-alpha-hydroxy-isomotiol as substrates to generate 19-beta-hydroxy-isomotiol and 2-alpha,19-beta-dihydroxy-isomotiol, respectively. These reactions occur with lower efficiency. Finally, fsoE can further convert 2-alpha,19-beta-dihydroxy-isomotiol into 2-alpha-hydroxy-ismotiol-19-one and 2-alpha-hydroxy-ismotiol-19-one into 2-deacetyl-3-deglucopyranosyl-fuscoatroside (PubMed:38654452)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "3-O-(beta-D-glucopyranosyl)-2alpha-hydroxyisomotiol + acetyl-CoA = 3-O-(beta-D-glucopyranosyl)-2alpha-acetoxyisomotiol + CoA", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:83523"}, {"database": "ChEBI", "id": "CHEBI:57287"}, {"database": "ChEBI", "id": "CHEBI:57288"}, {"database": "ChEBI", "id": "CHEBI:232475"}, {"database": "ChEBI", "id": "CHEBI:232477"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:83524"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}]}]}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "2-deacetylfuscoatroside + acetyl-CoA = fuscoatroside + CoA", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:83527"}, {"database": "ChEBI", "id": "CHEBI:57287"}, {"database": "ChEBI", "id": "CHEBI:57288"}, {"database": "ChEBI", "id": "CHEBI:232479"}, {"database": "ChEBI", "id": "CHEBI:232480"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:83528"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}]}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}], "value": "Secondary metabolite biosynthesis; terpenoid biosynthesis"}], "commentType": "PATHWAY"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000255"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000255"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38654452"}], "value": "Fuscoatroside and some of its derivatives show interesting antifungal activity against Candida albicans and Aspergillus niger"}], "commentType": "BIOTECHNOLOGY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the wax synthase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 419, "modifier": "EXACT"}}, "description": "Acetyltransferase fsoF", "featureId": "PRO_0000461499"}, {"type": "Transmembrane", "location": {"start": {"value": 4, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Transmembrane", "location": {"start": {"value": 62, "modifier": "EXACT"}, "end": {"value": 82, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Transmembrane", "location": {"start": {"value": 230, "modifier": "EXACT"}, "end": {"value": 250, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Transmembrane", "location": {"start": {"value": 314, "modifier": "EXACT"}, "end": {"value": 334, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Transmembrane", "location": {"start": {"value": 337, "modifier": "EXACT"}, "end": {"value": 357, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Transmembrane", "location": {"start": {"value": 386, "modifier": "EXACT"}, "end": {"value": 406, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Region", "location": {"start": {"value": 89, "modifier": "EXACT"}, "end": {"value": 114, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Glycosylation", "location": {"start": {"value": 2, "modifier": "EXACT"}, "end": {"value": 2, "modifier": "EXACT"}}, "description": "N-linked (GlcNAc...) asparagine", "evidences": [{"evidenceCode": "ECO:0000255", "source": "PROSITE-ProRule", "id": "PRU00498"}], "featureId": ""}, {"type": "Glycosylation", "location": {"start": {"value": 112, "modifier": "EXACT"}, "end": {"value": 112, "modifier": "EXACT"}}, "description": "N-linked (GlcNAc...) asparagine", "evidences": [{"evidenceCode": "ECO:0000255", "source": "PROSITE-ProRule", "id": "PRU00498"}], "featureId": ""}, {"type": "Glycosylation", "location": {"start": {"value": 169, "modifier": "EXACT"}, "end": {"value": 169, "modifier": "EXACT"}}, "description": "N-linked (GlcNAc...) asparagine", "evidences": [{"evidenceCode": "ECO:0000255", "source": "PROSITE-ProRule", "id": "PRU00498"}], "featureId": ""}], "keywords": [{"id": "KW-0012", "category": "Molecular function", "name": "Acyltransferase"}, {"id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38654452", "citationType": "journal article", "authors": ["Cao Z.Q.", "Wang G.Q.", "Luo R.", "Gao Y.H.", "Lv J.M.", "Qin S.Y.", "Chen G.D.", "Awakawa T.", "Bao X.F.", "Mei Q.H.", "Yao X.S.", "Hu D.", "Abe I.", "Gao H."], "citationCrossReferences": [{"database": "PubMed", "id": "38654452"}, {"database": "DOI", "id": "10.1021/jacs.4c02415"}], "title": "Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C-C Bond Cleavage.", "publicationDate": "2024", "journal": "J. Am. Chem. Soc.", "firstPage": "12723", "lastPage": "12733", "volume": "146"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [GENOMIC DNA]", "FUNCTION", "CATALYTIC ACTIVITY", "PATHWAY", "BIOTECHNOLOGY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR962264", "properties": [{"key": "ProteinId", "value": "XAF84281.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "UniPathway", "id": "UPA00213", "properties": [{"key": "RectionId", "value": "-"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0008374", "properties": [{"key": "GoTerm", "value": "F:O-acyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006629", "properties": [{"key": "GoTerm", "value": "P:lipid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR044851", "properties": [{"key": "EntryName", "value": "Wax_synthase"}]}, {"database": "InterPro", "id": "IPR032805", "properties": [{"key": "EntryName", "value": "Wax_synthase_dom"}]}, {"database": "PANTHER", "id": "PTHR31595", "properties": [{"key": "EntryName", "value": "LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31595:SF67", "properties": [{"key": "EntryName", "value": "WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13813", "properties": [{"key": "EntryName", "value": "MBOAT_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNHTIISLALIFFQLTTTALVVGFTSREHLFLRAIGSVPQGFSAYHQIVFLCSHISNPVNRAFLGAASVFLVILYVDAAILSRWTFASQSPTSSLGGLIPPTTRDTPKTQNNATTAETSASFLRKLSFGFLIALQSRFPATPWAVPRLPPFHKADPKHTPTKSAFLLKNTTKCLVYLLLLRATSGLGNPDDNPVVFASDRIPLFSRLGDKGPGGITLSEIGTRVGAVMGYWAIQYAVIDLLYSLLAVVAVSLHLTDVKGWVPVFGSVSDARGVRLFWGQFYHQLVRQGCSSIAHYITYFILRFRKDSGSLAARYVFMTLVFAVSGVFHTLSDVSQGIPLGESGAMRFFVLQAIGIMLEDGFQAIVSRRRQSGHHGRGKLERVLGSVSGPVWLVTWLTWTSPGWIYMSLQRDRGVPIIPF", "length": 419, "molWeight": 46038, "crc64": "407D133B7E22C198", "md5": "4DE9D6FD289B21E82409F92926F2D009"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 2, "PATHWAY": 1, "SUBCELLULAR LOCATION": 1, "BIOTECHNOLOGY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Transmembrane": 6, "Region": 1, "Glycosylation": 3}, "uniParcId": "UPI003366FED0"}, "cluster_size": 2, "family": "Chaetomiaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LKX2", "uniProtkbId": "A0AAU7LKX2_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28224.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28224.1"}], "value": "MADS29"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28224.1"}], "value": "MADS29"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 10, "modifier": "EXACT"}, "end": {"value": 59, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}, {"type": "Region", "location": {"start": {"value": 163, "modifier": "EXACT"}, "end": {"value": 202, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 163, "modifier": "EXACT"}, "end": {"value": 172, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 192, "modifier": "EXACT"}, "end": {"value": 202, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28224.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28224.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400864", "properties": [{"key": "ProteinId", "value": "XBP28224.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "3.40.1810.10:FF:000006", "properties": [{"key": "EntryName", "value": "Agamous-like MADS-box protein AGL62"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR11945:SF776", "properties": [{"key": "EntryName", "value": "AGAMOUS-LIKE 50-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11945", "properties": [{"key": "EntryName", "value": "MADS BOX PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MASDRTLIKKRENARQVAFSKRRLGLFKKASELSTLCAAEVALVVFSTSGKVYSFGHPSVKSVAHRFKEEGVKSDAKTVEHIANEEAASICNLNKQICNLQVQLEGEKKRSKKLKEEMMEDPMLYLFSAPINSLTLPQLFWLKEKCEELKEKVLKMREAKMAQESSYSSCGSCTEGADAPGTAAELSPKRGSSGGPDGHFVS", "length": 202, "molWeight": 22251, "crc64": "CB8DB46E32898026", "md5": "C9A7FF139629A643CD21F72486E96D79"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 2}, "uniParcId": "UPI0035D374B6"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39TYR7", "uniProtkbId": "A0AB39TYR7_MOUSE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84327.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84327.1"}], "value": "Neonatal crystallizable Fc receptor splice variant 5"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "MGI", "id": "MGI:103017"}], "value": "Fcgrt"}, "synonyms": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84327.1"}], "value": "FCGRT"}]}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004251"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004251"}], "value": "Single-pass type I membrane protein", "id": "SL-9905"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004608"}], "value": "Endosome membrane", "id": "SL-0100"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 236, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044200468"}, {"type": "Domain", "location": {"start": {"value": 27, "modifier": "EXACT"}, "end": {"value": 197, "modifier": "EXACT"}}, "description": "MHC class I-like antigen recognition-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00129"}]}, {"type": "Region", "location": {"start": {"value": 212, "modifier": "EXACT"}, "end": {"value": 236, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 212, "modifier": "EXACT"}, "end": {"value": 222, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022753"}], "id": "KW-0967", "category": "Cellular component", "name": "Endosome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023319"}], "id": "KW-0393", "category": "Domain", "name": "Immunoglobulin domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84327.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38607033", "citationType": "journal article", "authors": ["Haddad G.", "Blaine J."], "citationCrossReferences": [{"database": "PubMed", "id": "38607033"}], "title": "Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.", "publicationDate": "2024", "journal": "Cells", "firstPage": "0", "lastPage": "0", "volume": "13"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84327.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FV12BRJLLL9E9", "citationType": "submission", "authors": ["Haddad G.", "Blaine J."], "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84327.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ136843", "properties": [{"key": "ProteinId", "value": "XDQ84327.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "AGR", "id": "MGI:103017", "properties": [{"key": "Description", "value": "-"}]}, {"database": "MGI", "id": "MGI:103017", "properties": [{"key": "GeneName", "value": "Fcgrt"}]}, {"database": "GO", "id": "GO:0010008", "properties": [{"key": "GoTerm", "value": "C:endosome membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "FunFam", "id": "3.30.500.10:FF:000003", "properties": [{"key": "EntryName", "value": "IgG receptor FcRn large subunit p51"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.500.10", "properties": [{"key": "EntryName", "value": "MHC class I-like antigen recognition-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050208", "properties": [{"key": "EntryName", "value": "MHC_class-I_related"}]}, {"database": "InterPro", "id": "IPR011161", "properties": [{"key": "EntryName", "value": "MHC_I-like_Ag-recog"}]}, {"database": "InterPro", "id": "IPR037055", "properties": [{"key": "EntryName", "value": "MHC_I-like_Ag-recog_sf"}]}, {"database": "InterPro", "id": "IPR011162", "properties": [{"key": "EntryName", "value": "MHC_I/II-like_Ag-recog"}]}, {"database": "PANTHER", "id": "PTHR16675:SF3", "properties": [{"key": "EntryName", "value": "IGG RECEPTOR FCRN LARGE SUBUNIT P51"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR16675", "properties": [{"key": "EntryName", "value": "MHC CLASS I-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00129", "properties": [{"key": "EntryName", "value": "MHC_I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54452", "properties": [{"key": "EntryName", "value": "MHC antigen-recognition domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGMPLPWALSLLLVLLPQTWGSETRPPLMYHLTAVSNPSTGLPSFWATGWLGPQQYLTYNSLRQEADPCGAWMWENQVSWYWEKETTDLKSKEQLFLEALKTLEKILNGTFTLQGLLGCELASDNSSVPTAVFALNGEEFMKFNPRIGNWTGEWPETEIVANLWMKQPDAARKESEFLLNSCPERLLGHLERGRRNLEWKAPWLSLSGDDSGDLLPGGNLPPEAEPQGANAFPATS", "length": 236, "molWeight": 26436, "crc64": "C96F33371B0EDCF6", "md5": "E32540D6E0A66B3C15067377A558724E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI00388BE6C3"}, "cluster_size": 5, "family": "Muridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0Z2K6", "uniProtkbId": "A0AAF0Z2K6_SCHRI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Schizothorax richardsonii", "commonName": "Snowtrout", "synonyms": ["Cyprinus richardsonii"], "taxonId": 183910, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49195.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Cypriniformes", "Cyprinidae", "Schizothoracinae", "Schizothorax"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49195.1"}], "value": "Insulin-like growth factor 3 variant 1"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49195.1"}], "value": "IGF3"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009034"}], "value": "Belongs to the insulin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 101, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 94, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49195.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9HEQHHVU7TAI3", "citationType": "submission", "authors": ["Alexander C.", "Manchi R.", "Akhtar M.S.", "Kamalam B.S.", "Tripathi P.H.", "Sharma P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49195.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR757345", "properties": [{"key": "ProteinId", "value": "WPD49195.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005179", "properties": [{"key": "GoTerm", "value": "F:hormone activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005159", "properties": [{"key": "GoTerm", "value": "F:insulin-like growth factor receptor binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008283", "properties": [{"key": "GoTerm", "value": "P:cell population proliferation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0048009", "properties": [{"key": "GoTerm", "value": "P:insulin-like growth factor receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043066", "properties": [{"key": "GoTerm", "value": "P:negative regulation of apoptotic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008284", "properties": [{"key": "GoTerm", "value": "P:positive regulation of cell population proliferation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0051897", "properties": [{"key": "GoTerm", "value": "P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR036438", "properties": [{"key": "EntryName", "value": "Insulin-like_sf"}]}, {"database": "InterPro", "id": "IPR022353", "properties": [{"key": "EntryName", "value": "Insulin_CS"}]}, {"database": "PANTHER", "id": "PTHR46845:SF2", "properties": [{"key": "EntryName", "value": "INSULIN-LIKE GROWTH FACTOR 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46845", "properties": [{"key": "EntryName", "value": "INSULIN-LIKE GROWTH FACTOR I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56994", "properties": [{"key": "EntryName", "value": "Insulin-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00262", "properties": [{"key": "EntryName", "value": "INSULIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "QCCVRGCDLQHLESYCAKAKRVRRDVPASLQQTPEDQFWLVFQQRYQKHAEMNRDEEAASQRLKERTLYRWNSRDSVLLTNQQQPSTERISSEPTFLPHIR", "length": 101, "molWeight": 12064, "crc64": "2E61242490113F02", "md5": "296153F1CCE71BC9F12789E2A5B1BEDA"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Region": 1, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI002B2FDB1A"}, "cluster_size": 1, "family": "Cyprinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38YJY0", "uniProtkbId": "A0AB38YJY0_9TRYP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Blastocrithidia nonstop", "taxonId": 2592485, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58456.1"}], "lineage": ["Eukaryota", "Discoba", "Euglenozoa", "Kinetoplastea", "Metakinetoplastina", "Trypanosomatida", "Trypanosomatidae", "Blastocrithidia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58456.1"}], "value": "ATPase subunit 6"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58456.1"}], "value": "ATP6"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006810"}], "value": "Belongs to the ATPase A chain family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 84, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 90, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 137, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 162, "modifier": "EXACT"}, "end": {"value": 187, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 194, "modifier": "EXACT"}, "end": {"value": 212, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 218, "modifier": "EXACT"}, "end": {"value": 238, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "geneLocations": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58456.1"}], "geneEncodingType": "Mitochondrion"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023310"}], "id": "KW-0066", "category": "Biological process", "name": "ATP synthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022547"}], "id": "KW-0138", "category": "Cellular component", "name": "CF(0)"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022781"}], "id": "KW-0375", "category": "Biological process", "name": "Hydrogen ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58456.1"}], "id": "KW-0496", "category": "Cellular component", "name": "Mitochondrion"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FDG24681IABBA", "citationType": "submission", "authors": ["Afonin D.A."], "publicationDate": "APR-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58456.1"}], "value": "P57", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLJ58456.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ911731", "properties": [{"key": "ProteinId", "value": "WLJ58456.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005739", "properties": [{"key": "GoTerm", "value": "C:mitochondrion"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0045259", "properties": [{"key": "GoTerm", "value": "C:proton-transporting ATP synthase complex"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0015078", "properties": [{"key": "GoTerm", "value": "F:proton transmembrane transporter activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0015986", "properties": [{"key": "GoTerm", "value": "P:proton motive force-driven ATP synthesis"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR000568", "properties": [{"key": "EntryName", "value": "ATP_synth_F0_asu"}]}, {"database": "InterPro", "id": "IPR035908", "properties": [{"key": "EntryName", "value": "F0_ATP_A_sf"}]}, {"database": "PRINTS", "id": "PR00123", "properties": [{"key": "EntryName", "value": "ATPASEA"}]}, {"database": "SUPFAM", "id": "SSF81336", "properties": [{"key": "EntryName", "value": "F1F0 ATP synthase subunit A"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MINFVTVINFKYRIYSFLFFDFLVLRLLFNFLLLICNFYFMLVIFILFDSLYYSVVYFYDYYICGCLFFFVYWLMLFNIFGLILGTNITYLNVFILTIIVFLSYFSIIIFFLLLFIWKNFFHLLVGDRSMNIVYLRFFLCVLENFSIFCRFISTFLRMFCNLLASHFLMLLFCDFIVFLVIIVFALCAIWFSSIVLVFFLFFLFFLFALELFCSLLQIYIFCNMIFQLWLDFLLFFVIN", "length": 239, "molWeight": 29254, "crc64": "92BB8E1D02F96195", "md5": "5F3FCEEB9788A9EE55BAD51358446464"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6}, "uniParcId": "UPI00388BD854"}, "cluster_size": 1, "family": "Trypanosomatidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7YD16", "uniProtkbId": "A0AAU7YD16_NIDPL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Nidirana pleuraden", "commonName": "Yunnan pond frog", "synonyms": ["Babina pleuraden"], "taxonId": 369511, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87683.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Ranoidea", "Ranidae", "Nidirana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87683.1"}], "value": "Amplexin 9"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 115, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043919135"}, {"type": "Non-terminal residue", "location": {"start": {"value": 115, "modifier": "EXACT"}, "end": {"value": 115, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87683.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "38891597", "citationType": "journal article", "authors": ["Zheng P.", "Gong Y.", "Wang B.", "Yu H.", "Huang S.", "Liao X.", "Jiang J.", "Ran J.", "Xie F."], "citationCrossReferences": [{"database": "PubMed", "id": "38891597"}], "title": "Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.", "publicationDate": "2024", "journal": "Animals (Basel)", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87683.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-E24AGF4876IHP", "citationType": "submission", "authors": ["Zheng P."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87683.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP623144", "properties": [{"key": "ProteinId", "value": "XBY87683.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.10.60.10", "properties": [{"key": "EntryName", "value": "CD59"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR045860", "properties": [{"key": "EntryName", "value": "Snake_toxin-like_sf"}]}, {"database": "SUPFAM", "id": "SSF57302", "properties": [{"key": "EntryName", "value": "Snake toxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKAMITLLILGLLLIHGEALQCLKTINLGDVYYTESKINCTKNEYRCAVIQMLSLPQGYFSEGCATEERCQKMSSTNPLYGCCSTDLCNKLSYEEVCNAHEKKILKFRGRVPEEN", "length": 115, "molWeight": 13008, "crc64": "D29448059D2FD1AF", "md5": "645EF66847BC19B4EBE5AE7E6B5A3291"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D29DAA"}, "cluster_size": 4, "family": "Ranidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MMZ6", "uniProtkbId": "A0AA96MMZ6_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 9, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50048.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50048.1"}], "value": "Unconventional myosin-XV-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008314"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00782"}], "value": "Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 2832, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041658171"}, {"type": "Domain", "location": {"start": {"value": 127, "modifier": "EXACT"}, "end": {"value": 246, "modifier": "EXACT"}}, "description": "CUB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS01180"}]}, {"type": "Domain", "location": {"start": {"value": 382, "modifier": "EXACT"}, "end": {"value": 1061, "modifier": "EXACT"}}, "description": "Myosin motor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51456"}]}, {"type": "Domain", "location": {"start": {"value": 1249, "modifier": "EXACT"}, "end": {"value": 1397, "modifier": "EXACT"}}, "description": "MyTH4", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51016"}]}, {"type": "Domain", "location": {"start": {"value": 2106, "modifier": "EXACT"}, "end": {"value": 2167, "modifier": "EXACT"}}, "description": "SH3", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50002"}]}, {"type": "Domain", "location": {"start": {"value": 2367, "modifier": "EXACT"}, "end": {"value": 2523, "modifier": "EXACT"}}, "description": "MyTH4", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51016"}]}, {"type": "Domain", "location": {"start": {"value": 2528, "modifier": "EXACT"}, "end": {"value": 2832, "modifier": "EXACT"}}, "description": "FERM", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50057"}]}, {"type": "Region", "location": {"start": {"value": 939, "modifier": "EXACT"}, "end": {"value": 961, "modifier": "EXACT"}}, "description": "Actin-binding", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00782"}]}, {"type": "Region", "location": {"start": {"value": 1524, "modifier": "EXACT"}, "end": {"value": 1571, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1616, "modifier": "EXACT"}, "end": {"value": 1637, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1722, "modifier": "EXACT"}, "end": {"value": 1867, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 2185, "modifier": "EXACT"}, "end": {"value": 2247, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 1138, "modifier": "EXACT"}, "end": {"value": 1182, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1536, "modifier": "EXACT"}, "end": {"value": 1546, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1616, "modifier": "EXACT"}, "end": {"value": 1627, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1628, "modifier": "EXACT"}, "end": {"value": 1637, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1722, "modifier": "EXACT"}, "end": {"value": 1731, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1802, "modifier": "EXACT"}, "end": {"value": 1822, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1852, "modifier": "EXACT"}, "end": {"value": 1865, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 2194, "modifier": "EXACT"}, "end": {"value": 2229, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 475, "modifier": "EXACT"}, "end": {"value": 482, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00782"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023203"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00782"}], "id": "KW-0009", "category": "Molecular function", "name": "Actin-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00782"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023175"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00782"}], "id": "KW-0505", "category": "Molecular function", "name": "Motor protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023123"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00782"}], "id": "KW-0518", "category": "Molecular function", "name": "Myosin"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00782"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022443"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00192"}], "id": "KW-0728", "category": "Domain", "name": "SH3 domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50048.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460125", "properties": [{"key": "ProteinId", "value": "WNS50048.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016459", "properties": [{"key": "GoTerm", "value": "C:myosin complex"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0120025", "properties": [{"key": "GoTerm", "value": "C:plasma membrane bounded cell projection"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0003779", "properties": [{"key": "GoTerm", "value": "F:actin binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0003774", "properties": [{"key": "GoTerm", "value": "F:cytoskeletal motor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "CDD", "id": "cd00041", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd14473", "properties": [{"key": "EntryName", "value": "FERM_B-lobe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.10.820:FF:000001", "properties": [{"key": "EntryName", "value": "Myosin heavy chain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.10.820", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.5.190", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.530", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "6.20.240.20", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.850.10", "properties": [{"key": "EntryName", "value": "Kinesin motor domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.120.720", "properties": [{"key": "EntryName", "value": "Myosin VI head, motor domain, U50 subdomain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.25.40.530", "properties": [{"key": "EntryName", "value": "MyTH4 domain"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "2.30.29.30", "properties": [{"key": "EntryName", "value": "Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.30.30.40", "properties": [{"key": "EntryName", "value": "SH3 Domains"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.290", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR019749", "properties": [{"key": "EntryName", "value": "Band_41_domain"}]}, {"database": "InterPro", "id": "IPR000859", "properties": [{"key": "EntryName", "value": "CUB_dom"}]}, {"database": "InterPro", "id": "IPR035963", "properties": [{"key": "EntryName", "value": "FERM_2"}]}, {"database": "InterPro", "id": "IPR019748", "properties": [{"key": "EntryName", "value": "FERM_central"}]}, {"database": "InterPro", "id": "IPR000299", "properties": [{"key": "EntryName", "value": "FERM_domain"}]}, {"database": "InterPro", "id": "IPR000048", "properties": [{"key": "EntryName", "value": "IQ_motif_EF-hand-BS"}]}, {"database": "InterPro", "id": "IPR002404", "properties": [{"key": "EntryName", "value": "IRS_PTB"}]}, {"database": "InterPro", "id": "IPR036961", "properties": [{"key": "EntryName", "value": "Kinesin_motor_dom_sf"}]}, {"database": "InterPro", "id": "IPR001609", "properties": [{"key": "EntryName", "value": "Myosin_head_motor_dom-like"}]}, {"database": "InterPro", "id": "IPR000857", "properties": [{"key": "EntryName", "value": "MyTH4_dom"}]}, {"database": "InterPro", "id": "IPR038185", "properties": [{"key": "EntryName", "value": "MyTH4_dom_sf"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR011993", "properties": [{"key": "EntryName", "value": "PH-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR036028", "properties": [{"key": "EntryName", "value": "SH3-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR001452", "properties": [{"key": "EntryName", "value": "SH3_domain"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "InterPro", "id": "IPR051567", "properties": [{"key": "EntryName", "value": "Unconventional_Myosin_ATPase"}]}, {"database": "PANTHER", "id": "PTHR22692", "properties": [{"key": "EntryName", "value": "MYOSIN VII, XV"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22692:SF26", "properties": [{"key": "EntryName", "value": "SH3 DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00431", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00373", "properties": [{"key": "EntryName", "value": "FERM_M"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00612", "properties": [{"key": "EntryName", "value": "IQ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02174", "properties": [{"key": "EntryName", "value": "IRS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00063", "properties": [{"key": "EntryName", "value": "Myosin_head"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00784", "properties": [{"key": "EntryName", "value": "MyTH4"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Pfam", "id": "PF07653", "properties": [{"key": "EntryName", "value": "SH3_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00193", "properties": [{"key": "EntryName", "value": "MYOSINHEAVY"}]}, {"database": "SMART", "id": "SM00295", "properties": [{"key": "EntryName", "value": "B41"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00042", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00015", "properties": [{"key": "EntryName", "value": "IQ"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SMART", "id": "SM00242", "properties": [{"key": "EntryName", "value": "MYSc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00139", "properties": [{"key": "EntryName", "value": "MyTH4"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00326", "properties": [{"key": "EntryName", "value": "SH3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50729", "properties": [{"key": "EntryName", "value": "PH domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47031", "properties": [{"key": "EntryName", "value": "Second domain of FERM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50044", "properties": [{"key": "EntryName", "value": "SH3-domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01180", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50057", "properties": [{"key": "EntryName", "value": "FERM_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50096", "properties": [{"key": "EntryName", "value": "IQ"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS51456", "properties": [{"key": "EntryName", "value": "MYOSIN_MOTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51016", "properties": [{"key": "EntryName", "value": "MYTH4"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50002", "properties": [{"key": "EntryName", "value": "SH3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQYTMLVILLVCLADACLSAPFAFGGSPFGFPFGGPKHEPMSSVYDWDLNQELVHKTYLGEWTANCMVVYARALAWLERDKQGSGRVRLIEYADVPSSVEYKSNDRYHYYLGYVRDIRPGKEQTLWCRPASTLYFSSHDNQIVNGTADGNYLPGKETVWMISFSQPTQVALLLKNINLEDSAGCRNDYISFYANGQDEKTASTFYCSKLNVDPPHSTFYNVTNFTIKFQTNENLEFSGFSGALVVVNSTSNPSMNYISKRSTRQVKKERVAEDEDVLQKGLEEGMEPLWNSTVTQSEIGVVDCVSKILQDGLEAVELLREVPSCEEPGSKVWFPTEGGFSAPGIVASSSPGSTVKVSHELNPDEVLSVDALDLKKREDFGENGVEDMTQLNDLHEGALLYNIKTRFTKNHIYTFTGSILVSVNPYEVFNIYSMADVRRYQGQPLGKLPPHIFAISSCAYLQMMKSHVGQCIVISGESGSGKTEATKLVMQYLAATDEDDGQTMTAEQILEANPLLESFGNAKTIRNDNSSRFGKYLEIYFNNSGSISGAKVSEYLLEKSRIVSAASGERNYHIFYEMLSGLSSEEKARYKLQGPQHFRYTSQEAALVIAGKDDRADFQRLQSSMEVLGITAEEKKVIFEILAAILHLGNVTFTATTVNGQDGVSLANSPELVTVAGLILVEEGQLRTQLTHKVTLTRGEYFHSPLSLDQALDTRDALSKAMYSRLFTWLVGRINHVIHSGGCNHANSIAVLDIFGFENFAVNSFEQLCINYANESLQFNFNQHIFALEQQEYHREGIEWSTLDYKDNQPCLDLINKKPDGIFVILDDESSFPKATDQSFLDKCHRQHGKNPFYQQPKKNSPQFAVNHYAGTVWYSGKMFLDKNRDTMRSDLVELLCNSHSKLVADLFLGVLEELQDVKTRTMSTRRKARTVAYNFTQSLGKLLRTINKCSPFFVRCVKPNDEKVPKVFRDSTVMEQLRYSGMLETIRIRAAGYPARLEHQAFLTRYQCLCPGVARGEGGEVVGRCRELLQGLGLAEDSFQIGGSKVFMREPAERGLEERRADRLETCARRLQALLRAHTARRRYTALRKATIVLQAAVKGWTARRKFLLVLGGVVRFQALYRMHRARLSYRELLAAKARERALQLAAEEEARQKAEQERVLQEEQQRELERQQRERQARQDVLRLEVPADLAFVLHCVDESEERSLFVPVKTKFLSCSQASTALPDDIDGFSFQKFAGMYFQEGHIWAMSKEPLPKALLKQKDPSLEETALGLFKLVMRFMSDKSQLSDTKQRIIGNYIVFKALSSPALCEELLCELVNQTWCNQEERSRQRGWLLLSVAAGCLQPSPRLEPYLLNYVSDFGFGEYRSVSQDKLLRADRAKPNRSCSPCDLEWASAKAGSAMALLVAYPDGTSTHVEVGSWSTAQELATIVASDRGLPSDRAGPWSFVLKQGKSRVELMGPGYVLDGLSALECPQGTEQACPSPHLVCKEDLYHSRSHLEQVDTFLDVIFGDFLEGASAEIPSPSELASNIKGGGGPPPPPPPPPPVKERVQAKSKPGLPKPAKKAPLPAPPTDFRAELMAKMSRAKGQVSEETVRHSEVLPSGGLKTFSAHSTTTVVGSQSGSETSPAVTRSGSPMATNSLSSVAALASKFGVGQVSMATKQEVFVTSEDEQLYICSSSSFSEDEQLYICSSSSFSEDEQLYICSSSSFSEDGQLYICSSSSFSKDSSTSSPPPPSVKMNSSTSVPPPPSVKMNSSTSVPPPPSVKMNSSTSVPPPPSVKMDSSTSVPPPPSVKMNSSTSVPPPPPHSPPHSPPPPPPPPAVRQESRAAVVEESPEETLQASNVRVSFPSLPAPEPGSPGPPGSPVVVQRRLRRRSSGAILQRMSNSMKRWSVITADPVLDAPAPPDEPIRLHSVARVTPLTYSSGGACLRLSKELMTPTESPSQGAEIQIIYRQVLDDVWTGASLKLTSKERRELKALLDQHGITPSSCQTSLPVMKTVIDLAMKAAIYFSRVYKVTGPAPSPAPSPAYSHVCIGRTAVVLACGIGEEQELDIKAHYKFEEVQSFECEESSVRLCVGGQTYTFNTSYAEDFVNLLTSQINELSQSTHYVVSVADYDALEETLLPFSSGAVIKLLVRDTQEEGWLYGECNGHEGSFPSELVVPIATQGIGPPSQETIEIALANAKRSEHRRQSSQLKRQPSQKLKRQPSQLKRQPSQKLQRQPSQLKKQTSELKQRSSEVTTLSQESIQKQVTSQVGVTTITSDLAISKSSSVARAVLTTQESIELTDEDCAPPEAPPQLPAHKLSMMKFAMDHFRQGEERYELERQLKTSRGLVGTLRNTVRGSRRGKQGAESWTWSGLAELVKYSKSPLQSSLLVLDREDVALNKMAIECFRAIMRFMGDYMAKGTSDKDQVLLVLKSCREREDIRDEVYCQLIKQTTNNRSAKSESCQRGWVLTMICCAYFPPSQQFMPFFQHYISSNSSDSKREFYSLAKMCETNLKKTVRFGGRKNPPSSQELQALAMGRYTKRQAFLLPGNIKKLLRIRTSTVSEDIVREICSMMCLEPEFTKECGLQAEFAGQSTPLTLNPNDYLLDVMSILERQGIDHAFSFRRALWLLPTRLDNNLAVDMLYHQVLPDWRNGNMAQVESEGLQIRQIDQMAVLAALQWRAQEETDCPDKNSIIKLVPSGMLGQVEMEEWIRLIGEHFESISTLISVEAKARFIDLASSLPLYGSSFFNLEGVSSPTVPGPCLLAVNAKGVVFLDSQTKAVLQAVEYSEVISTRKLRSHVGKQFVDIKCGNLMRQRVLRCETPYARDIGGLISGYIKAQRKKT", "length": 2832, "molWeight": 314565, "crc64": "C97BB4D9492072DF", "md5": "063F0830199382CB05FD29CFAF253D14"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 6, "Region": 5, "Coiled coil": 1, "Compositional bias": 7, "Binding site": 1}, "uniParcId": "UPI002B2FF342"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLQ8", "uniProtkbId": "A0AAU0QLQ8_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56465.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 40, "modifier": "EXACT"}, "end": {"value": 58, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 70, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 135, "modifier": "EXACT"}, "end": {"value": 155, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 188, "modifier": "EXACT"}, "end": {"value": 212, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56465.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56465.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970358", "properties": [{"key": "ProteinId", "value": "WPO56465.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFQYYHLKRSHRETYPFSWFDIIGIRFFDAPDKFFIKTKVRFIAFVLSFYFLCSVVTYECFKYDEASIRGLASIIPSGILGVIGVAKQNIVFRPKNRQRVAKLIKEIDELWPSEDQLVEYGKKKILDDWIKKSAIFFRCIFCAALAHAVFSTFIMSPSVLYYKRYVNPNVEIQEPIPMSVIRFECPKALFIVYILYQAVISVAFEVICYFSLNIVIGLKIMNIKALFIILQVDLENIIKEEKLNQIVSNTDHCYDELKKIVQRHQKILSICDNLNELYSFTTFLDVTCAATVMAFYGFAVATEVNVVNRVLHALRMASVSLTVLLLTWPAEVLAGANDGVAEAAYSCLWYLGNARIKSLVLLVMQRAMIPVYLKAFIFSNVVLETYSKLCSTAFSYVSVLSQVHEK", "length": 406, "molWeight": 46619, "crc64": "0DB59B873FA7243F", "md5": "F9A7B7E123EC26068AAC1281D01685E9"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 4}, "uniParcId": "UPI003086CBFB"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA95Z987", "uniProtkbId": "A0AA95Z987_9CUCU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Anthonomus eugenii", "commonName": "pepper weevil", "taxonId": 122869, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96197.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Coleoptera", "Polyphaga", "Cucujiformia", "Curculionidae", "Curculioninae", "Anthonomini", "Anthonomus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96197.1"}], "value": "Odorant binding protein 83b"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96197.1"}], "value": "OBP83b"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96197.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 137, "modifier": "EXACT"}, "end": {"value": 137, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96197.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DHPI8O2N9J4MB", "citationType": "submission", "authors": ["Segura Leon O.L.", "Lechuga-Paredes P.", "Cibrian Tovar J.", "Torres Huerta B."], "publicationDate": "JUL-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96197.1"}]}, {"referenceNumber": 2, "citation": {"id": "36834814", "citationType": "journal article", "authors": ["Lechuga-Paredes P.", "Segura-Leon O.L.", "Cibrian-Tovar J.", "Torres-Huerta B.", "Velazquez-Gonzalez J.C.", "Cruz-Jaramillo J.L."], "citationCrossReferences": [{"database": "PubMed", "id": "36834814"}], "title": "Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.", "publicationDate": "2023", "journal": "Int. J. Mol. Sci.", "firstPage": "0", "lastPage": "0", "volume": "24"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96197.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP056794", "properties": [{"key": "ProteinId", "value": "WNH96197.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "PANTHER", "id": "PTHR21364", "properties": [{"key": "EntryName", "value": "GENERAL ODORANT-BINDING PROTEIN 19A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21364:SF2", "properties": [{"key": "EntryName", "value": "GENERAL ODORANT-BINDING PROTEIN 19A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00708", "properties": [{"key": "EntryName", "value": "PhBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "SQCFVLCAYGILAKLTKEDFREDYRPFLGDLHKNCTDQTGISDEEVKNLKDGIFDHNEKATCFTKCLLVGSEILNDEGKLNEDPFKNIETDEVRKRVQKSYEAAYSIADKLGYDDLCNKSYALVQGLYLSDPGDFFV", "length": 137, "molWeight": 15568, "crc64": "1FEF145F59CB5591", "md5": "BD4C407C817686F6909AA622476BD973"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI002B30FD14"}, "cluster_size": 1, "family": "Curculionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBG0", "uniProtkbId": "A0AAU6PBG0_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20566.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20566.1"}], "value": "Venom peptide"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 42, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043683218"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20566.1"}], "value": "U_LCTX_55_Cm34", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20566.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480835", "properties": [{"key": "ProteinId", "value": "WXB20566.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MYRLVLVFSVIALLSLVGAAESVQKRSPIDDSIMASLVGSGV", "length": 42, "molWeight": 4393, "crc64": "5C20F5085CCF82A7", "md5": "DC1B3C120E5A90C0B5E7CE97CE525C66"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D303B1"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEP5", "uniProtkbId": "A0AB38ZEP5_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02736.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02736.1"}], "value": "Heteropteran venom family 5 protein 3"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 218, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044294643"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02736.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517486", "properties": [{"key": "ProteinId", "value": "WXI02736.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MISYKVFRSVVAFILAFVTTSVLTSPTLVNDKIDEIIPHINRHFASKLFDVVQIPDYGYQGSPVYIGVALRNLTTFYRTGDCVVWAEGENVRLRMNLGLRDMKTNVRLVTYMNGPGGFVFEGASAEMGIVMVPEGVDGCRIFWDYVIITTLGNVVGYSFNQQYNGVPPPNQLDGDVIPYYNQRFNGGEIFTIRNLNMFLNLCDLPIVADAFRSFKRRT", "length": 218, "molWeight": 24591, "crc64": "7B38F56B15366A52", "md5": "7F44C86B1EA335ABC4AF1C42D715A09C"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C1D4F"}, "cluster_size": 2, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA86J3J7", "uniProtkbId": "A0AA86J3J7_BRACM", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Brassica campestris", "commonName": "Field mustard", "taxonId": 3711, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDB39443.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "malvids", "Brassicales", "Brassicaceae", "Brassiceae", "Brassica"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDB39443.1"}], "value": "S-locus cysteine-rich protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDB39443.1"}], "value": "SCR-77"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006722"}], "value": "Belongs to the DEFL family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDB39443.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C9RPND062LQ27", "citationType": "submission", "authors": ["Yamamoto M.", "Ishii T.", "Ogura M.", "Akanuma T.", "Zhu X.", "Kitashiba H."], "title": "Updating of a comprehensive list of S haplotypes of Brassica rapa, Brassica oleracea and Raphanus sativus.", "publicationDate": "OCT-2021", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDB39443.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC652455", "properties": [{"key": "ProteinId", "value": "BDB39443.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR010682", "properties": [{"key": "EntryName", "value": "SCRL"}]}, {"database": "Pfam", "id": "PF06876", "properties": [{"key": "EntryName", "value": "SCRL"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "EGCFHDEPFDGRCIEPRNEFCAALFRNQLNEQTAFNCTCITAHSRAHCRCRLARKC", "length": 56, "molWeight": 6491, "crc64": "80CD283F20B3F539", "md5": "D855DE6AB16C937CF1DA93C39FFD17F3"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI002B28D771"}, "cluster_size": 1, "family": "Brassicaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QJX5", "uniProtkbId": "A0AAU0QJX5_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56497.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56497.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 67, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 120, "modifier": "EXACT"}, "end": {"value": 139, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 154, "modifier": "EXACT"}, "end": {"value": 154, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56497.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56497.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56497.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56497.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970390", "properties": [{"key": "ProteinId", "value": "WPO56497.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MLRTRHNIGALNCLNTQKALMFYYRASIKELIDEMSHDYMSYNSLPHRYQIKIDSLISKCVVYTEKVWTISVAIAVTVFPFVAVITTLYSHIFDEMPKRYMVHDINNPFAEPEERFESPFYEIVFAFMTGSIIVWIVNYSSFDALFGILTNHAC", "length": 154, "molWeight": 17971, "crc64": "923B76C76CCB8B33", "md5": "FF706BB7947D55310C4C3A5E9F47CAB4"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 1}, "uniParcId": "UPI0030868FCC"}, "cluster_size": 2, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEJ5", "uniProtkbId": "A0AB38ZEJ5_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02705.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02705.1"}], "value": "Heteropteran venom family 11 protein 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 162, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044223670"}, {"type": "Coiled coil", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 48, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02705.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517455", "properties": [{"key": "ProteinId", "value": "WXI02705.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MFKFLILIAVIACTIHANVSDKDLKRMISKLERSISRLERTGKIMKAKLKNFTDKLLEHTEEDNGETGKKCFLDLWKSLEETLNLKIDESIGGYTRSSRSLINNLKNGLFDKEELERTKHMLSKDGSYFGQIENSLQYLKRSIKKDLINFEKTVHDKCCQHD", "length": 162, "molWeight": 18829, "crc64": "440F595B43C6BB6B", "md5": "D44E4B3DC42019D51DB6047B2EA8161E"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Coiled coil": 1}, "uniParcId": "UPI00388BDF54"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UV99", "uniProtkbId": "A0AAT9UV99_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41604.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41604.1"}], "value": "Cytochrome P450 6PU1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 458, "modifier": "EXACT"}, "end": {"value": 458, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41604.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117164", "properties": [{"key": "ProteinId", "value": "WIM41604.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000042", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDLFSVTLIILTAITVLAYLYYLLKKQFDYWKVLNVPYLETPSYIFGQAKRCATGELSLAESHLQIYRDLAPHKYGGIFLFQNPSLIVRDPELVKHVLAKDFTNFYDRGSYFAKPYEPLTRHLFNLTGEEWKTIRTKLTPTFSGGKLKLMFAYVKECVDELITVIDELHDEEIEMKDLMARYTVDVISSCAFGLKTNSLRHPDAEFKKMGTQALSPTTWTRIKDTLTAISPKLVYFLKIRTFDTQVTEFFNRIVRQTVEYREKNNITRNDFLHLVTQLKKKDETDSLKNNSDGIILNEKSVELTLDLVTAQCFVIFLGGFETSSSALSFTLFELSRNPRVQQELQQDVDRVFDKYHDQITYESLQETTYADMVINETLRKYPAIPFLIRICTTDYKIPESSTVIKRGTWTFIPIYGLHHDPAYFSHPDDFYPEHFTEEAIKSRPHFTFLPFGEGPRICIGWRFGLMQVKLALVSLIRNYSFSLSPNMKLPMTFVKHTVLTHSENGILIVCKKRNTLLIN", "length": 519, "molWeight": 60234, "crc64": "95777C28261C74C1", "md5": "89B7506F621E0DFF7FB242516AD06B31"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D353E5"}, "cluster_size": 3, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEB1", "uniProtkbId": "A0AB38ZEB1_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71719.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71719.1"}], "value": "Venom S1 protease 12"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 137, "modifier": "EXACT"}, "end": {"value": 359, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}, {"type": "Region", "location": {"start": {"value": 88, "modifier": "EXACT"}, "end": {"value": 125, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 99, "modifier": "EXACT"}, "end": {"value": 117, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 359, "modifier": "EXACT"}, "end": {"value": 359, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71719.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022825"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023145"}], "id": "KW-0865", "category": "PTM", "name": "Zymogen"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71719.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510794", "properties": [{"key": "ProteinId", "value": "WXH71719.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00190", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.40.10.10:FF:000146", "properties": [{"key": "EntryName", "value": "Serine protease 53"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001314", "properties": [{"key": "EntryName", "value": "Peptidase_S1A"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR018114", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24252", "properties": [{"key": "EntryName", "value": "ACROSIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24252:SF7", "properties": [{"key": "EntryName", "value": "HYALIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00722", "properties": [{"key": "EntryName", "value": "CHYMOTRYPSIN"}]}, {"database": "SMART", "id": "SM00020", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00134", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKWKFITSRNAKISVFCKQIILGSSCSEGKLITYGGLYSSQICRTGYNVYVDTSKRNVLLVELVTKQLSSAGYLDCLVEAVPRNARVDGSRPHHFQHIKSKEHDDNDSKSSSDSREHGKPKKTTCKCGYSKKNRGRIVNGDVVNKGEYPWVVAILQGGGVFCGGSIITEYHVLTAAHCTVGKQARSISIMTGTIDSRQTKNGQVIEVEKIITHNYDKSKFHFNDISILFTKKKIKFSDYVGPICLTPNQVDLNDKSVTVMGWGSLGPNAGWILSTRMMKAKHRVVDFNTCSFLWYRQFDKNHQNRVCAWSSDKTACFGDSGGPLVWLDPEIKRYTQVGLVSFGRGCATSVPTVYTNIAY", "length": 359, "molWeight": 40025, "crc64": "D7DACA18795AD1B4", "md5": "BA6EDD567ED4BD820572A2393D22D872"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388C32A2"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LKV9", "uniProtkbId": "A0AAU7LKV9_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28259.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28259.1"}], "value": "MADS64"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28259.1"}], "value": "MADS64"}}], "features": [{"type": "Repeat", "location": {"start": {"value": 9, "modifier": "EXACT"}, "end": {"value": 43, "modifier": "EXACT"}}, "description": "PPR", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00708"}]}, {"type": "Repeat", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 78, "modifier": "EXACT"}}, "description": "PPR", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00708"}]}, {"type": "Repeat", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 113, "modifier": "EXACT"}}, "description": "PPR", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00708"}]}, {"type": "Repeat", "location": {"start": {"value": 114, "modifier": "EXACT"}, "end": {"value": 148, "modifier": "EXACT"}}, "description": "PPR", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00708"}]}, {"type": "Domain", "location": {"start": {"value": 315, "modifier": "EXACT"}, "end": {"value": 435, "modifier": "EXACT"}}, "description": "Peptidase S26", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF10502"}]}, {"type": "Region", "location": {"start": {"value": 286, "modifier": "EXACT"}, "end": {"value": 311, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 293, "modifier": "EXACT"}, "end": {"value": 302, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Active site", "location": {"start": {"value": 327, "modifier": "EXACT"}, "end": {"value": 327, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR600223-1"}]}, {"type": "Active site", "location": {"start": {"value": 377, "modifier": "EXACT"}, "end": {"value": 377, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR600223-1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28259.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28259.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400899", "properties": [{"key": "ProteinId", "value": "XBP28259.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006465", "properties": [{"key": "GoTerm", "value": "P:signal peptide processing"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd06530", "properties": [{"key": "EntryName", "value": "S26_SPase_I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.25.40.10", "properties": [{"key": "EntryName", "value": "Tetratricopeptide repeat domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.10.109.10", "properties": [{"key": "EntryName", "value": "Umud Fragment, subunit A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036286", "properties": [{"key": "EntryName", "value": "LexA/Signal_pep-like_sf"}]}, {"database": "InterPro", "id": "IPR000223", "properties": [{"key": "EntryName", "value": "Pept_S26A_signal_pept_1"}]}, {"database": "InterPro", "id": "IPR019756", "properties": [{"key": "EntryName", "value": "Pept_S26A_signal_pept_1_Ser-AS"}]}, {"database": "InterPro", "id": "IPR019533", "properties": [{"key": "EntryName", "value": "Peptidase_S26"}]}, {"database": "InterPro", "id": "IPR002885", "properties": [{"key": "EntryName", "value": "PPR_rpt"}]}, {"database": "InterPro", "id": "IPR011990", "properties": [{"key": "EntryName", "value": "TPR-like_helical_dom_sf"}]}, {"database": "NCBIfam", "id": "TIGR00756", "properties": [{"key": "EntryName", "value": "PPR"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "NCBIfam", "id": "TIGR02227", "properties": [{"key": "EntryName", "value": "sigpep_I_bact"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47931", "properties": [{"key": "EntryName", "value": "OS01G0228400 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47931:SF2", "properties": [{"key": "EntryName", "value": "OS01G0228400 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10502", "properties": [{"key": "EntryName", "value": "Peptidase_S26"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01535", "properties": [{"key": "EntryName", "value": "PPR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF12854", "properties": [{"key": "EntryName", "value": "PPR_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13041", "properties": [{"key": "EntryName", "value": "PPR_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00727", "properties": [{"key": "EntryName", "value": "LEADERPTASE"}]}, {"database": "SUPFAM", "id": "SSF51306", "properties": [{"key": "EntryName", "value": "LexA/Signal peptidase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51375", "properties": [{"key": "EntryName", "value": "PPR"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS00501", "properties": [{"key": "EntryName", "value": "SPASE_I_1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEECGVKPDVITFSTIMNQWSSTGLMKKCQEVFNNMVKVGIEPDVHAFSILAKGYVRAREPGKAESLLTSMTKYGLHPNVVIFTTIISGWCNAGKMERALRLLEKMYEMDVPPTLRTFETLLWGYGEAKQPWKAEELLQLMEEKGVPPENSTVKLVVEAWRSIGLLSEAERFLNEEEEREDDEDKEMDETPLEILETIYKKKHLGASYSNILQVPGVVVTNTENSSSANIRSQMAWKQMVFTSESMKNSTKSILVSYSSRFGVQPMIICKKQFQSPFRTCRSKTKAVLDSGGSDDGGGSGDGDGNDGKIDKTDGTFVAEPRCIPSLSMYPTFAVGDRFLAEKVTYYFRKPCANDIVIFKGPPVLQEVGYTDDDVFIKRIVAKEGDMVEGMLIVNGQERNENVIFEPPSYELTPTRVPENTVFVMGDNRNNSYDLHVCFGGTFFETGCAVEKQESNQAIKSSSSLPAKLYGKEVYN", "length": 475, "molWeight": 53146, "crc64": "5D86661B2F473FBD", "md5": "134247A21F9B01AB216C7A1403534CFC"}, "extraAttributes": {"countByFeatureType": {"Repeat": 4, "Domain": 1, "Region": 1, "Compositional bias": 1, "Active site": 2}, "uniParcId": "UPI0035D3269B"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7L216", "uniProtkbId": "A0AAU7L216_MACNP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Macrobrachium nipponense", "commonName": "Oriental river shrimp", "synonyms": ["Palaemon nipponensis"], "taxonId": 159736, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBO81859.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Caridea", "Palaemonoidea", "Palaemonidae", "Macrobrachium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBO81859.1"}], "value": "Toll2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Single-pass type I membrane protein", "id": "SL-9905"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009634"}], "value": "Belongs to the Toll-like receptor family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 745, "modifier": "EXACT"}, "end": {"value": 765, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 792, "modifier": "EXACT"}, "end": {"value": 931, "modifier": "EXACT"}}, "description": "TIR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50104"}]}, {"type": "Region", "location": {"start": {"value": 950, "modifier": "EXACT"}, "end": {"value": 991, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 950, "modifier": "EXACT"}, "end": {"value": 971, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 972, "modifier": "EXACT"}, "end": {"value": 982, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022859"}], "id": "KW-0391", "category": "Biological process", "name": "Immunity"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022588"}], "id": "KW-0399", "category": "Biological process", "name": "Innate immunity"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022614"}], "id": "KW-0433", "category": "Domain", "name": "Leucine-rich repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4NC4TTNOGURGB", "citationType": "submission", "authors": ["Zheng L.", "Ren Q."], "title": "Regulation of AMPs expression by Six Tolls in stomach during WSSV infection in Macrobrachium nipponense.", "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBO81859.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP842886", "properties": [{"key": "ProteinId", "value": "XBO81859.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0038023", "properties": [{"key": "GoTerm", "value": "F:signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045087", "properties": [{"key": "GoTerm", "value": "P:innate immune response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.40.50.10140:FF:000001", "properties": [{"key": "EntryName", "value": "Toll-like receptor 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.80.10.10", "properties": [{"key": "EntryName", "value": "Ribonuclease Inhibitor"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Gene3D", "id": "3.40.50.10140", "properties": [{"key": "EntryName", "value": "Toll/interleukin-1 receptor homology (TIR) domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001611", "properties": [{"key": "EntryName", "value": "Leu-rich_rpt"}]}, {"database": "InterPro", "id": "IPR003591", "properties": [{"key": "EntryName", "value": "Leu-rich_rpt_typical-subtyp"}]}, {"database": "InterPro", "id": "IPR032675", "properties": [{"key": "EntryName", "value": "LRR_dom_sf"}]}, {"database": "InterPro", "id": "IPR000157", "properties": [{"key": "EntryName", "value": "TIR_dom"}]}, {"database": "InterPro", "id": "IPR035897", "properties": [{"key": "EntryName", "value": "Toll_tir_struct_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24365:SF541", "properties": [{"key": "EntryName", "value": "PROTEIN TOLL-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24365", "properties": [{"key": "EntryName", "value": "TOLL-LIKE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13855", "properties": [{"key": "EntryName", "value": "LRR_8"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Pfam", "id": "PF01582", "properties": [{"key": "EntryName", "value": "TIR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01537", "properties": [{"key": "EntryName", "value": "INTRLKN1R1F"}]}, {"database": "SMART", "id": "SM00369", "properties": [{"key": "EntryName", "value": "LRR_TYP"}, {"key": "MatchStatus", "value": "9"}]}, {"database": "SMART", "id": "SM00255", "properties": [{"key": "EntryName", "value": "TIR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52058", "properties": [{"key": "EntryName", "value": "L domain-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF52200", "properties": [{"key": "EntryName", "value": "Toll/Interleukin receptor TIR domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51450", "properties": [{"key": "EntryName", "value": "LRR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50104", "properties": [{"key": "EntryName", "value": "TIR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKEELREELQEDVRELKSRCTFLPVGQVDSRSLTLPDSLNTHLAEVKAKHSNFSEVSVGSPYGPRLPEGCYRMLSAEDDRSVITCSGSNLTVIPEFRVRRINQLYFRDTAILKVTHDQIANLPRTLNGLAFSDGVLTFFDGRTLKYVEDLTMLSLKNNFVSGWSFAMVFQDDNNPNYTHSLRHLDLQKNYLSYPPDPMGSEPVKMPYLETIGLNHNPLCYLPEKLFKPLRNSPVRRLYMKNCSLCDFHGQPLSYLRHLEVLDLSANTGMDVSQIARFLKPLKDGQLRELYLAQNNYATVPKTALSLVNATLEKLDLHAAAFTCLDNTSFPMMPRLKILNLMYSRIYSIEEQTFATLPMLEELYLDGNYLQSFPAAVLLPSLRKLSMIENPTYTGGDASRSFNMGNVNLSKMKNLLSLALDKVQLTEVKNTYFLGLYELLNLSMVDCHITTIEPYSFRNLTKLQTLYLDKNSLTLMANETFRGLRNLKNLSLTKNNIAFFSRDIIYHLWAGVGKPTVDTRDTRSATVKDSWPGSDPLSYARAFEDLVVTFGKNRVTLPEGREATLQREYAASQGALTEDGGKEPTAYFPFGGLENLQYLWLSDNQIRCLVPEIFRDLVNLEVLNLGYNEIDQWYEPILQRSQKLTFLSLEKNSVKVLTEAMVEDLQIKSLESINLKNNILLCNCSLAFFNGSLDTSIFVDFSSYDCCKNNKYYNVSVVLQELDCPDDSASKGDDDPEAATVLEMKLVIGIVVALPAVVVFAFLVIYKRRWYIRYIVYSMKSGMKMYKEDDDSYLYDTFVCYSQADRQWVFEHLLRKLEDMAKYRVCVHERDFAVGQEITENIIYSVEKSRKVIVVLTPSFVASSWCMFELQMASNKILDEKKSKLILILLEEIPAKDQSKKLRLLLKTRTYITWEKSEEQHRFFWARLFRAIAKPSDTEGLRTVSSSAELVGSSSTSSSTSGSLESSSSSVSPFPPPSPPPPSSSSSLAPYTNFTLDESDVTNIHL", "length": 1005, "molWeight": 114235, "crc64": "937BCACDF67C1B20", "md5": "BA35A19EF10C1BF2295BB954162C8B70"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1, "Region": 1, "Compositional bias": 2}, "uniParcId": "UPI0035D3A1D0"}, "cluster_size": 4, "family": "Palaemonidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39IY59", "uniProtkbId": "A0AB39IY59_PENIN", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Penaeus indicus", "commonName": "Indian white prawn", "synonyms": ["Fenneropenaeus indicus"], "taxonId": 29960, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDL39901.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Dendrobranchiata", "Penaeoidea", "Penaeidae", "Penaeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDL39901.1"}], "value": "Stylicin antimicrobial peptides"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDL39901.1"}], "value": "STYL"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDL39901.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FOFQLOJIRTOK9", "citationType": "submission", "authors": ["Naveenkumar R.", "Panigrahi A.", "Bedekar M.", "Saranya C."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDL39901.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ114162", "properties": [{"key": "ProteinId", "value": "XDL39901.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSQGSSFSPPRGLPGWKDLCPPQSCPVCPGECPKCDGFPVCHEVCPDIAIGCDCPFYHNC", "length": 60, "molWeight": 6414, "crc64": "DBC1CA315C1E4254", "md5": "15BADC41369C4CC91805A911060AFA28"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI00388BBBCB"}, "cluster_size": 1, "family": "Penaeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HC20", "uniProtkbId": "A0AA96HC20_9BILA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tubulanus polymorphus", "taxonId": 672921, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25275.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Nemertea", "Palaeonemertea", "Tubulaniformes", "Tubulanidae", "Tubulanus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25275.1"}], "value": "Hypoxia-inducible factor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 106, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00353"}]}, {"type": "Domain", "location": {"start": {"value": 122, "modifier": "EXACT"}, "end": {"value": 188, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00091"}]}, {"type": "Domain", "location": {"start": {"value": 252, "modifier": "EXACT"}, "end": {"value": 318, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00091"}]}, {"type": "Region", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 629, "modifier": "EXACT"}, "end": {"value": 655, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 646, "modifier": "EXACT"}, "end": {"value": 655, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25275.1"}], "value": "Tubul1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25275.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ355010", "properties": [{"key": "ProteinId", "value": "WNN25275.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd11433", "properties": [{"key": "EntryName", "value": "bHLH-PAS_HIF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "4.10.280.10:FF:000076", "properties": [{"key": "EntryName", "value": "hypoxia-inducible factor 3-alpha isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR014887", "properties": [{"key": "EntryName", "value": "HIF-1_CTAD"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR001610", "properties": [{"key": "EntryName", "value": "PAC"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "NCBIfam", "id": "TIGR00229", "properties": [{"key": "EntryName", "value": "sensory_box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23171", "properties": [{"key": "EntryName", "value": "bHLH_HIF1A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08778", "properties": [{"key": "EntryName", "value": "HIF-1a_CTAD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14598", "properties": [{"key": "EntryName", "value": "PAS_11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00353", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00086", "properties": [{"key": "EntryName", "value": "PAC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MCGKGRPKSVFCGCKDADEWNMINRNETDKQDKRCNSSVRNTEKRKEKSRDAARCRRGKETEIFTELADQLPIPQGCVISQLDKASIMRLAISYLKIRTILGTADCPKDDDVNDFSDEDDLKYEQQYLKAMNGFLMVVEKDGDMIYVSDNVKKYFGIPQVDIIGLSIYEFSHPCDHDEIREMLLEKPHQLENSTDERQFFMRMKCTLTNKGKNVNLKSATYKVVRCQGHMLPVDQKILGHCVVLVGEPIPHPSNINMPLDSKTFLSKHNMGMKFIYCDERISKLLGYNSDELVGKSVYEYHHASDGDENEKAFKNLFSKGQATTHQYRFLAKGGGFAWLITQASVIYNTQTQKPQSVACLNYVISEIIEPGLILSQIQISEEKDKDEPPAIVMSTDKIFVQRTKDMEKDFFMPKDQTSLDLDDLTHLAPTAGDVCIPLGFPSSPNTLLNDFEKQKTNDNPDEEELVALSIKTEPFLPLDLTDCSRDCCTSPESDISDSSPVLVSPISPPSAREFVPGIMVDKENAPRTPPRMCESPIDSLDYEKRAPFIPDDDWMFTPATHSIFKNPPPEIIMKPQKPKHMMTLSTMLRPPDTSSIVKDKITRTIDLTKYTLSTAKNQLKLIQQKRQTVGRRLAADGTQTGQTRKSTGEADERPKTERIIGSSGGSVLMNLLLRGEDRNHGYTVESLLPQHSNVRVSAMKRKHSAEGNMLPQITRRDAEVNAPMPVFEDYLLRGQDLLSALDLVDII", "length": 747, "molWeight": 84323, "crc64": "7B694C1BD7EB0CDB", "md5": "130E8F49D56E4239A7D06846A7B3C108"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 2, "Compositional bias": 2}, "uniParcId": "UPI002B29E130"}, "cluster_size": 3, "family": "Tubulanidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PAT9", "uniProtkbId": "A0AAU6PAT9_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20552.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20552.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 75, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043873461"}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20552.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 75, "modifier": "EXACT"}, "end": {"value": 75, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20552.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20552.1"}], "value": "U_LCTX_30_Cm20", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20552.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480821", "properties": [{"key": "ProteinId", "value": "WXB20552.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "TNKAAAMTGCALIFIFVAVFQVITAQGPPPFPPNLPPQCRGPPPGAGKPHECCKVPAFFTDEDFSGCGFQKLDPE", "length": 75, "molWeight": 7919, "crc64": "5E0EF8E4999B9659", "md5": "A123D5752CE0CA9526A06BCFE97F36D9"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D2AD56"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7J8K0", "uniProtkbId": "A0AAU7J8K0_LOCMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Locusta migratoria", "commonName": "Migratory locust", "taxonId": 7004, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89727.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Polyneoptera", "Orthoptera", "Caelifera", "Acrididea", "Acridomorpha", "Acridoidea", "Acrididae", "Oedipodinae", "Locusta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89727.1"}], "value": "Tudor domain-containing protein Tdr24"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 111, "modifier": "EXACT"}, "end": {"value": 168, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Region", "location": {"start": {"value": 270, "modifier": "EXACT"}, "end": {"value": 296, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 270, "modifier": "EXACT"}, "end": {"value": 286, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3S1R4NEJO2BB6", "citationType": "submission", "authors": ["Deng S.", "Wang J.", "Ma E.", "Zhang J.", "Xing S."], "title": "Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89727.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR912226", "properties": [{"key": "ProteinId", "value": "XBN89727.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043186", "properties": [{"key": "GoTerm", "value": "C:P granule"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030719", "properties": [{"key": "GoTerm", "value": "P:P granule organization"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0034587", "properties": [{"key": "GoTerm", "value": "P:piRNA processing"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007283", "properties": [{"key": "GoTerm", "value": "P:spermatogenesis"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.50.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR035437", "properties": [{"key": "EntryName", "value": "SNase_OB-fold_sf"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR050621", "properties": [{"key": "EntryName", "value": "Tudor_domain_containing"}]}, {"database": "PANTHER", "id": "PTHR22948:SF29", "properties": [{"key": "EntryName", "value": "FI02030P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22948", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50304", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSPKSNVRNGRSNERAAGNSNGVVLVSSDYIPAPYPEDVVNHRHIIIHEELPDNVLYSAELQVYVRKVNSPSEFWINLCGSDYSRKLVDLYADMRQFYQQKQDRYLLPNYAVLVGQFCVCSHINEWHRARIVNASDKELVDVFLIDCGGTVTVSTNNLRYMHKQFSYLPVQSFLANLPDIKPRSGADWSTSVCEFFHQETAGKKLFAKVLNVATEKHTVSLKLLDASRNSISDKLISNNMARAKGKGFDAPAMRNGGSLVSSLGASSLKVDNTDTSSRSEDNSTLPESDEAVSRGSDAPVTCNTWRNVYHNDVTVAGKKLLLLTVEDKNYFVLSEFLQAFSVLHEHVVLKLLETFPSRVVVEKMADRQLTALLRRSVKGRRIRGLAHLADRGVDPRVRLLPVGAACQLLAFLGADGSQRISLHNFVCSWAAGASF", "length": 435, "molWeight": 48392, "crc64": "FC6E4D3058951092", "md5": "B4796F18E0D36A83D47C62111F7C8E2D"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D399A0"}, "cluster_size": 3, "family": "Acrididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEH7", "uniProtkbId": "A0AB38ZEH7_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02672.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02672.1"}], "value": "Venom cystatin 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 117, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044256840"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02672.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517422", "properties": [{"key": "ProteinId", "value": "WXI02672.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "3.10.450.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR046350", "properties": [{"key": "EntryName", "value": "Cystatin_sf"}]}, {"database": "SUPFAM", "id": "SSF54403", "properties": [{"key": "EntryName", "value": "Cystatin/monellin"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLKFVRIIAVFACVLLINHVEAQEPRPTNIPCKGCTYKLEVDDEHINYTLKKILAGRSDNLELVKIIKVTGQPLDGIKYKIQFEAVDKMTNDAKICDTIFYLKNKDIDMRTFNCAAK", "length": 117, "molWeight": 13379, "crc64": "B1A44B6CEE4EA4CC", "md5": "3FD3EB636E58E8CB3F1B79DFC9C5441D"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BE92D"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZE86", "uniProtkbId": "A0AB38ZE86_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71730.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71730.1"}], "value": "Heteropteran venom family 5 protein 2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 207, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044285176"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71730.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510805", "properties": [{"key": "ProteinId", "value": "WXH71730.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MPSRKELVTLLCLLNAVFVFSETKLVNEDIDQKLAKYNAGAKDIGLVTMEIVDLKVNGFKIKRARLGIMHGLRRDGDVYREDSANSITYRGIVSMVPFVIEAGELSYGAYNGPANITADLATADFSFTSSNLVPGDCETHWNKFTILSPMKNVILHMAMGHNEDITDEVNNNFLPKFNQLFKTDELIKVLNERFDFCDLILGISKLF", "length": 207, "molWeight": 23217, "crc64": "AF517E5B5D6B0BD7", "md5": "2CAD6AFF8BEAF779283FBF8798CCD504"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C2473"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEF9", "uniProtkbId": "A0AB38ZEF9_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02663.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02805.1"}], "value": "Venom redulysin 11"}}, {"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02663.1"}], "value": "Venom redulysin 2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 275, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044174135"}, {"type": "Region", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 59, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02663.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517413", "properties": [{"key": "ProteinId", "value": "WXI02663.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "EMBL", "id": "PP517555", "properties": [{"key": "ProteinId", "value": "WXI02805.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSKLWLLLLLVAAFQFVHAHPAEEYEVDEFASDEAEEYLNDEPQMSDEEETDYLEDGEDEERGFKLKKIKPGKIFKKTKDGLAKAGKKLKQLGKKAKDLAKKGAKMLKDLGVTITPLKCEDKKCQSCIGFKPLQQSCCIVFVISRTQNKNLYLTITAELNGKALFTPTKLRIGEVPKCLNAGDFMGKFCMKGFEAHAKSSEGKPHLHFCVVCFSEKLNMGVKLCASYINKKMDLRVSPKFFPAVLSDDGEIVKVDEATDEAVVVEDEGEFEDLDF", "length": 275, "molWeight": 30840, "crc64": "232CB2EC158047F0", "md5": "3BEF16AC171FF81B93D20AC118A6B967"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1}, "uniParcId": "UPI00388C2B42"}, "cluster_size": 3, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBH2", "uniProtkbId": "A0AAU6PBH2_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20563.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20563.1"}], "value": "Venom peptide"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 34, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043727852"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20563.1"}], "value": "U_LCTX_82_Cm31", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20563.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480832", "properties": [{"key": "ProteinId", "value": "WXB20563.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MTKFLILCFVATLMLAQVSLADPVVSDETIAFGD", "length": 34, "molWeight": 3660, "crc64": "0444E39DFA9B99B6", "md5": "18553074ECB4E5F09DDF2B4E2EC65DCB"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D3AF07"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0Z0M7", "uniProtkbId": "A0AAF0Z0M7_BEMTA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Bemisia tabaci", "commonName": "Sweetpotato whitefly", "synonyms": ["Aleurodes tabaci"], "taxonId": 7038, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD72777.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Aleyrodoidea", "Aleyrodidae", "Aleyrodinae", "Bemisia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD72777.1"}], "value": "Peptidoglycan recognition protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD72777.1"}], "value": "PGRP"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007553"}], "value": "Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 91, "modifier": "EXACT"}}, "description": "Peptidoglycan recognition protein family", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00701"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD72777.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 91, "modifier": "EXACT"}, "end": {"value": 91, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD72777.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022859"}], "id": "KW-0391", "category": "Biological process", "name": "Immunity"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022588"}], "id": "KW-0399", "category": "Biological process", "name": "Innate immunity"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3M38ONM43R8M5", "citationType": "submission", "authors": ["Singh A.", "Ghosh A."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD72777.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR659741", "properties": [{"key": "ProteinId", "value": "WPD72777.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008745", "properties": [{"key": "GoTerm", "value": "F:N-acetylmuramoyl-L-alanine amidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0045087", "properties": [{"key": "GoTerm", "value": "P:innate immune response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0009253", "properties": [{"key": "GoTerm", "value": "P:peptidoglycan catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd06583", "properties": [{"key": "EntryName", "value": "PGRP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.80.10", "properties": [{"key": "EntryName", "value": "Peptidoglycan recognition protein-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036505", "properties": [{"key": "EntryName", "value": "Amidase/PGRP_sf"}]}, {"database": "InterPro", "id": "IPR002502", "properties": [{"key": "EntryName", "value": "Amidase_domain"}]}, {"database": "InterPro", "id": "IPR015510", "properties": [{"key": "EntryName", "value": "PGRP"}]}, {"database": "InterPro", "id": "IPR006619", "properties": [{"key": "EntryName", "value": "PGRP_domain_met/bac"}]}, {"database": "PANTHER", "id": "PTHR11022", "properties": [{"key": "EntryName", "value": "PEPTIDOGLYCAN RECOGNITION PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11022:SF77", "properties": [{"key": "EntryName", "value": "PEPTIDOGLYCAN-RECOGNITION PROTEIN LB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01510", "properties": [{"key": "EntryName", "value": "Amidase_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00701", "properties": [{"key": "EntryName", "value": "PGRP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55846", "properties": [{"key": "EntryName", "value": "N-acetylmuramoyl-L-alanine amidase-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "GPIDKYDPEQPPSMVIIHHSRLPPCSTTESCIVRMLELQRLHQRDRHWFDIGFNFAIGGDGSVYEGRGWNQKPAAVKKYNNKSINIAFLGD", "length": 91, "molWeight": 10367, "crc64": "4FA64127EDF17E73", "md5": "3048ECC936FA370992C30054C29C6AFE"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2EAA23"}, "cluster_size": 1, "family": "Aleyrodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LVY7", "uniProtkbId": "A0AAN0LVY7_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34063.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34063.1"}], "value": "G-protein coupled receptor 3"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004487"}], "value": "Cell projection, neuron projection", "id": "SL-0518"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007242"}], "value": "Belongs to the G-protein coupled receptor 3 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 604, "modifier": "EXACT"}, "end": {"value": 630, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 642, "modifier": "EXACT"}, "end": {"value": 663, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 675, "modifier": "EXACT"}, "end": {"value": 693, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 714, "modifier": "EXACT"}, "end": {"value": 737, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 777, "modifier": "EXACT"}, "end": {"value": 797, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 809, "modifier": "EXACT"}, "end": {"value": 828, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 840, "modifier": "EXACT"}, "end": {"value": 862, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 605, "modifier": "EXACT"}, "end": {"value": 866, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 3 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50259"}]}, {"type": "Region", "location": {"start": {"value": 979, "modifier": "EXACT"}, "end": {"value": 1000, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 990, "modifier": "EXACT"}, "end": {"value": 1000, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023273"}], "id": "KW-0966", "category": "Cellular component", "name": "Cell projection"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34063.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34063.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154989", "properties": [{"key": "ProteinId", "value": "WRW34063.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043005", "properties": [{"key": "GoTerm", "value": "C:neuron projection"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd15293", "properties": [{"key": "EntryName", "value": "7tmC_GPR158-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR017978", "properties": [{"key": "EntryName", "value": "GPCR_3_C"}]}, {"database": "InterPro", "id": "IPR043458", "properties": [{"key": "EntryName", "value": "GPR158/179"}]}, {"database": "InterPro", "id": "IPR054714", "properties": [{"key": "EntryName", "value": "GPR158_179_extracellular"}]}, {"database": "PANTHER", "id": "PTHR32546", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR 158-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR32546:SF26", "properties": [{"key": "EntryName", "value": "SMOG, ISOFORM D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00003", "properties": [{"key": "EntryName", "value": "7tm_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF22572", "properties": [{"key": "EntryName", "value": "GPR158_179_EC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50259", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F3_4"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFDNSSMHIFVLSTWFYKYLENIKKNNGLKNLIRKKFFCKLFVFFVLKLLIKQLEASSIENYSLKDSNLFPFHNLINNNSFYRNKHFYRKFNSYLKNQYFNNKIRPFLHHSKHKKASEKSIYLPLKQAKTNSWSVLGDHDAEYALKSLESDHLTSAILHFIEITYEYSKITSNNSQQFNEFKKTKNKFFNSGSCVQVKLDPLRNLINENSFKKYNKQAETAIRTANLLTTLLSQSLINSNDIDKKFLVFNNNSNKLELDKQFFWSLLQVNLQSDLNLFANGIVFKPDENQLKKFSNQNDDENKELKNELFSPYVFRKKEKVNSKNSSSFNLFNYINLSALPSFNQRVVPNPKSNNTSTDIPESMKEKETNLKNLKNLLQNTNKPLIDIYSYSSDWYQVFSDYYSNNSNKNLTLIDYNNLKKTNYLITKVEQGYWTVPYSDCSATKTWLLSYSVPFFGLNKLRNKIEFKGVVLISIDLSSQDINQCSTEDTFFPKSHKCDRQTTECLPTKGLGFRRGAYLCQCKPGYYIPNFTYTSSFHKNDSINILSKRHFFNGSIIESAFVSTYIDPQHDPSLFPFHFQCLACPKDCSECNSNQSCKVNYTGLLRIIILGVQSFCVTIVIILAATTFRLRRSKSFASSRWLILEALLFGCLLLYINVIIQYFEPKPLNCFIEPWFRELGFGFCYGSIIIKLYRIYAEFQTRKAHRVCVRDKDLLKYLCSIILIIIGYMAAWSALILDTINGYSNLITQSAEIYILQVGKTANNLKFYICKQLSWDYVTQSGELSFVFAGVYLSYCIRNARSELYREKWALSTCIYIEFFISSFFYILRNFFWYNFHPDYIYLMYFLRCQLTVSVILILVFGPKIFFRHSQKISKSTQNKSRFFTGQQARDRVPEAMKLHAAILSNGEIDVSDINLSDMDPEDIRNELRRVYTQMQVLKNKTICKENPHISKRRGGRKSAHRRFSLQTFAHSKHIHKSMHHQHDHEQEITEVSRTPEESTASIDCQSVAYCEGQSSVLSSK", "length": 1021, "molWeight": 119259, "crc64": "2DFD55DA0B3DA200", "md5": "F414F579BC18FF91D5CD61023E65D279"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI003252A768"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MMB8", "uniProtkbId": "A0AA96MMB8_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50051.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50051.1"}], "value": "Tyrosine kinase-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 491, "modifier": "EXACT"}, "end": {"value": 605, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Domain", "location": {"start": {"value": 611, "modifier": "EXACT"}, "end": {"value": 734, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Domain", "location": {"start": {"value": 739, "modifier": "EXACT"}, "end": {"value": 859, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Domain", "location": {"start": {"value": 880, "modifier": "EXACT"}, "end": {"value": 1161, "modifier": "EXACT"}}, "description": "Protein kinase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50011"}]}, {"type": "Domain", "location": {"start": {"value": 881, "modifier": "EXACT"}, "end": {"value": 970, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023319"}], "id": "KW-0393", "category": "Domain", "name": "Immunoglobulin domain"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50051.1"}], "id": "KW-0418", "category": "Molecular function", "name": "Kinase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50051.1"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50051.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460128", "properties": [{"key": "ProteinId", "value": "WNS50051.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043235", "properties": [{"key": "GoTerm", "value": "C:receptor complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004714", "properties": [{"key": "GoTerm", "value": "F:transmembrane receptor protein tyrosine kinase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007169", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor protein tyrosine kinase signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "1.10.510.10", "properties": [{"key": "EntryName", "value": "Transferase(Phosphotransferase) domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR013098", "properties": [{"key": "EntryName", "value": "Ig_I-set"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR011009", "properties": [{"key": "EntryName", "value": "Kinase-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR000719", "properties": [{"key": "EntryName", "value": "Prot_kinase_dom"}]}, {"database": "InterPro", "id": "IPR050122", "properties": [{"key": "EntryName", "value": "RTK"}]}, {"database": "InterPro", "id": "IPR001245", "properties": [{"key": "EntryName", "value": "Ser-Thr/Tyr_kinase_cat_dom"}]}, {"database": "InterPro", "id": "IPR008266", "properties": [{"key": "EntryName", "value": "Tyr_kinase_AS"}]}, {"database": "InterPro", "id": "IPR020635", "properties": [{"key": "EntryName", "value": "Tyr_kinase_cat_dom"}]}, {"database": "PANTHER", "id": "PTHR24416", "properties": [{"key": "EntryName", "value": "TYROSINE-PROTEIN KINASE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24416:SF611", "properties": [{"key": "EntryName", "value": "TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07679", "properties": [{"key": "EntryName", "value": "I-set"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07714", "properties": [{"key": "EntryName", "value": "PK_Tyr_Ser-Thr"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00219", "properties": [{"key": "EntryName", "value": "TyrKc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SUPFAM", "id": "SSF56112", "properties": [{"key": "EntryName", "value": "Protein kinase-like (PK-like)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS50011", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00109", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_TYR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGVQYYESGNTLYNCIVKLSTMLTGGAEFDEFSRTTNPEYCSSADQWRCTMKLPPPTCVPDCIVDGKSGDDAVISWNIDSSRDYNFDLKDSQGNAVLPPTFPQRLSGKQPDENAFYKINSSKGVITMPNSLLYVETFTVSITDLAPTSTHKEVASFKVQKGCNPSKPLNLDTSSMCQDAQSVMTLSWDVGSKRSYKYIIESSSQSYEGEVPGSGNSDFIVTNGRGSINVNVADGSYKVKVTDLTSGVTEFQSESTSINVPECKPPHPLNLVTPSCIKSSASSFQISWSAKVDRVYSWKLTNGGSNFASGKLSNGASTSDVVYNPTTEMATLTISAPSGGEFVTGQYMIVVTDLSSYASSSEQAEFPLKKGCKDTIPLDILAQGMCKNGTSAFSISWAVKKSRDYYYEVKRGSTVVQEGTVSGAGEIGFEVSNGRGTIISTGPLVSGDYSVEVQDLDAGVDAYYTEDASFTVSSKPVIDRGKPKPAAAVVLPTIADSLERDRKIKIGANKLVLPGYSFTIICGPVVTYCRSVPPYNITYTWYKDEAHLTTTVYNISAATTEASPCAPSTLTILVNTSDPGQAAGRYKCLAANEIGQDEAESNMRLGIEIVAPPVFLNQATGTDVVVINGSTIPTPCKLPMGNNVVISEVGKLTSLTFYCSLLTIGIPSANISWTVNGRSLINSRWFRSSLNVTNSTDNSTSRMLVNVSNFISSFLCCKAENIAGKDLLCSELKLPSAKSPEASFQTFGSNALIVKDALVNNGTKSLRLPVVLGRWSCVCENKEGSINSSIPVGPCFCRVLQARPDPSVKWFRNGELLSNNTNQTTLRVHVNSSEPAAAAGDYRCTAENAVANDTAHSNMTLGKEILVLPRLLRSTKHYENMPENITVFFGDSSVVQRGKSVTIHCSVVDAGIPQSELSWMDRQNLTASKGVSWSDDGNLTIETALVNATDLRYCCTARNEAGSDTACSNITIEGAYCGLECPGHSQLNRTSCECIAGSGDLLPAIIGAELTLPLEEWELSHSDLEVQGLLGKGQFGNVKLALLDADCNTGRVKNYVDQKFIGCVLSALPVAVVMEFVPFGDLRSNLMKWKVESHLASLNVIHRDLACRNVLVGENKTLKVSDFGLSKEIDGVYTSTSKTKLPIRWMSPEAIRHRIFSQKSDV", "length": 1161, "molWeight": 125242, "crc64": "D37030B4297357E7", "md5": "611585902FDBB961E11DD70476301CAE"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 5}, "uniParcId": "UPI002B2B3700"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMQ0", "uniProtkbId": "A0AAU0QMQ0_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56498.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 81, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 143, "modifier": "EXACT"}, "end": {"value": 164, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 201, "modifier": "EXACT"}, "end": {"value": 234, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 331, "modifier": "EXACT"}, "end": {"value": 352, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56498.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56498.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970391", "properties": [{"key": "ProteinId", "value": "WPO56498.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSIISDDDFQAVTKVTNIKYIRIVKYNLKILNAWPSTLVGEMDSKYIRIRKTALMFVEAFCLLPQALYIRNSTGVLGFHELGHSYITMFMNIVAVSRLVLTFSVKYYEIVANFVNKIHLFHFKHQSEYAMETHLLVHKLSRFFTLYINLLLYSGVCVFNLTLVYTNYVSGALTNLRETEVPFQHALYMAVPFDYTTEYKGAIFIFWFNVIISYICSSIFCTFDLFLSLLVFHLWGHLRILIHNLENFPRPKQSYKPEGYANEVNYEWYTKEENKEVADRLKDIINHHIFITDYIKQMMNIFGPSLFVIYAFHQVSECLLLLQLAQLEAKAFFMYGPLTLTLVQQLIQLSFIFDMLQSMTSSLVRAVYSLPWECMDNPNRRIVNLLLSQCYRPLTPKALGVLDVGCKTMVAIFKNTLSYFIMLQTVAGMDK", "length": 430, "molWeight": 50120, "crc64": "24E343B5B76EC53D", "md5": "38E43DC80E56A9B7D6E913A97C8E09D2"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 5}, "uniParcId": "UPI00308B94B8"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHY1", "uniProtkbId": "A0AAN0LHY1_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34080.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34080.1"}], "value": "Neuropeptide SIFamide receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 7, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 61, "modifier": "EXACT"}, "end": {"value": 86, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 98, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 135, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 177, "modifier": "EXACT"}, "end": {"value": 197, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 448, "modifier": "EXACT"}, "end": {"value": 472, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 776, "modifier": "EXACT"}, "end": {"value": 795, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 815, "modifier": "EXACT"}, "end": {"value": 840, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 77, "modifier": "EXACT"}, "end": {"value": 837, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34080.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155006", "properties": [{"key": "ProteinId", "value": "WRW34080.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR45695:SF9", "properties": [{"key": "EntryName", "value": "LEUCOKININ RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45695", "properties": [{"key": "EntryName", "value": "LEUCOKININ RECEPTOR-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQTKLKVFFIFMFFNFNFSSALIDSCLCDDEFNSSNCLNSNEIVYDINETPMFRHTILVSVIYLIAYSLVFILGFIGNCCVIFVVIRSSQMRNATNFFICNLALADMLVVICCLPATLIGHLFKPWILGWFLCKAVSYFQGVAVSASINTLMAVSIERYLAICFPFKPQMRGSQAKKWIIIIWILSLSIASPWAFFFQLSPMYQQNSTLENETNSLISQNLIKSNKILNLTKQQKNRSVSSNQCLLCKDKEKLEIKFLEKFFFFFDQLIMNQLILVSKENFEDYAFNSSIKSVNFDEIDFNYLNLIIMKWPSIFCDCFNFEKINLIEFENDVKISKKFDKNNLISIKQKLKKSFEKAFSIKEQKLKNLNDLEICKVQTNCELENIKCKSFNKLVNQVNFFQKFNDDYISFEEKSFKIENYENKNYENEFLNYELCTELWPNKTLERTYFIFANLILCYLFPLIIISACYIAIWTTVWHRSVPGEFSEKKNEKFFLKNNVMSYEIGSEKKKRFKRFSFDFNLSKRRNEKKNEICFQQSFESLDENKNLMNSKNKITYSIKNSHSLDENKLKKLSFLEMKDLNERKLLIKSLSIPEKIQTLNTKKTTNTKQFTETKQTIVSINNNLSKINLTNKSLDNLDERNNLNFVDKMKKFFIKEKDKLKNEKLNLSTIENLNSEISLPIQNNSSNDSKKGKKTFNHQFDEKFLSKNLNEDDIKEVSRKNDDVFELKKQISSTKTIHNLNKKICRSKYLTQLNSSIQTNRFQLILQRSRYKVAKMMIIVVLVFFLSWLPLYLIFTKIKLSLELTSFPDSEDRIIRLLAPFAQWLGASNSCINPLLYAFFNKKYYSEFVKIFSNINCLHFFKKENKNDLKNMKTLIMKKQSKRHPSMTTN", "length": 890, "molWeight": 104874, "crc64": "52DC8C87BF0C2A72", "md5": "CED3F4267252392C1B4271A67D553785"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 8, "Domain": 1}, "uniParcId": "UPI00324FC153"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UUA7", "uniProtkbId": "A0AAT9UUA7_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41704.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41704.1"}], "value": "Cytochrome P450 4461J3 short isoform"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41704.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117264", "properties": [{"key": "ProteinId", "value": "WIM41704.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF177", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4AA1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAFLIVIAFLATVYLSTLLYKKKHQRYYDLLKQFPSPPTYPFIGNMKPSHFVINNIVKELSESHDRVIYWMGPKPILVLKKFDDISIFLNQNSERNLTKISKHWAGEAILNNKHVEWKKSRKLINPAFSSQMIEKYFDVFNKRSFALVDKLKLYADTGKEVDIHKYLLNSNIEGLIENLTGAPIRTSEKEVDDFGVALKDVLHGVARGITSPWLYSDTIYSVYLKLTGNMKLIKELNYLPAKIVRENLKDANEKYRSETADSSKCLIDLMVKAQQKDSTFTETRLEHEFLQLMSAGTDASALNASFTLLMLAIHQDVQQKVYEEITQLVGEHDAFTSDHLSNHLKYLEQCIRETLRMYDPVAVTIRESQKEHVLKGIIQISTDRNYSIKKHSSISR", "length": 396, "molWeight": 45672, "crc64": "2BB5F1A62E8D72D5", "md5": "56E94DD71397E7ADF66F8433C02A85AC"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SIMILARITY": 1}, "uniParcId": "UPI0035D28A96"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0MTP0", "uniProtkbId": "A0AAU0MTP0_UREUN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Urechis unicinctus", "commonName": "Fat innkeeper worm", "synonyms": ["Chinese penis fish"], "taxonId": 6432, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59948.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Echiura", "Xenopneusta", "Urechidae", "Urechis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59948.1"}], "value": "Heat shock protein family A member 12 variant X10"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59948.1"}], "value": "HSPA12"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007381"}], "value": "Belongs to the heat shock protein 70 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59948.1"}], "id": "KW-0346", "category": "Biological process", "name": "Stress response"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FQL9M4QGPVUS3", "citationType": "submission", "authors": ["Liu D.D."], "publicationDate": "FEB-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59948.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OM803169", "properties": [{"key": "ProteinId", "value": "WOS59948.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0140662", "properties": [{"key": "GoTerm", "value": "F:ATP-dependent protein folding chaperone"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.30.420.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.90.640.10", "properties": [{"key": "EntryName", "value": "Actin, Chain A, domain 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR043129", "properties": [{"key": "EntryName", "value": "ATPase_NBD"}]}, {"database": "InterPro", "id": "IPR013126", "properties": [{"key": "EntryName", "value": "Hsp_70_fam"}]}, {"database": "PANTHER", "id": "PTHR14187", "properties": [{"key": "EntryName", "value": "ALPHA KINASE/ELONGATION FACTOR 2 KINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14187:SF5", "properties": [{"key": "EntryName", "value": "HEAT SHOCK 70 KDA PROTEIN 12A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00012", "properties": [{"key": "EntryName", "value": "HSP70"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53067", "properties": [{"key": "EntryName", "value": "Actin-like ATPase domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFEAGLWREGRASQLILSIESEAASVWCLDQVIKSGQKKFLLVDVGGGTTDISAHEVLRGRGLRQLCESRGISYGGDNVNKRYAKMLATILGDGVMADFKSKHAADYLDHMRGFEEQKRIFRPNQSDGISLSIQNSLLTVYAEHTRKKFKQAFTDYYPDIIDYEDNRIHIKTEGVTKMFGRVIQKILKHIEVMQRETEGIDKVLLVGGFSGCPMLQRAVRETFQGQGRVVVPDHPGLCVVKGAVQYGFRSDVITSRVAKRTYGFLQCKRYDPNLHDEKRARLIEIDDTLCCSNLVKRIVTKGENVAQDFEFSVRCRPVQRDQRGIELILLSFNDPDVKYCILEEEPELHAKIVVPVKAGGQVQVRCLFGGTEIRLLARDADGLSDWHETTVGFLCY", "length": 396, "molWeight": 44755, "crc64": "769937A248FDC923", "md5": "E047F53EA868439A976A905990A910B8"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0035D2C73D"}, "cluster_size": 2, "family": "Urechidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LP64", "uniProtkbId": "A0AAN0LP64_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34067.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34067.1"}], "value": "G protein-coupled receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "value": "Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 47, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}]}, {"type": "Transmembrane", "location": {"start": {"value": 59, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}]}, {"type": "Transmembrane", "location": {"start": {"value": 99, "modifier": "EXACT"}, "end": {"value": 118, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}]}, {"type": "Transmembrane", "location": {"start": {"value": 139, "modifier": "EXACT"}, "end": {"value": 162, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}]}, {"type": "Transmembrane", "location": {"start": {"value": 210, "modifier": "EXACT"}, "end": {"value": 237, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}]}, {"type": "Transmembrane", "location": {"start": {"value": 337, "modifier": "EXACT"}, "end": {"value": 359, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}]}, {"type": "Transmembrane", "location": {"start": {"value": 371, "modifier": "EXACT"}, "end": {"value": 397, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}]}, {"type": "Domain", "location": {"start": {"value": 38, "modifier": "EXACT"}, "end": {"value": 394, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU046427"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34067.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154993", "properties": [{"key": "ProteinId", "value": "WRW34067.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0042277", "properties": [{"key": "GoTerm", "value": "F:peptide binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005000", "properties": [{"key": "GoTerm", "value": "F:vasopressin receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0032870", "properties": [{"key": "GoTerm", "value": "P:cellular response to hormone stimulus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd15196", "properties": [{"key": "EntryName", "value": "7tmA_Vasopressin_Oxytocin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR001817", "properties": [{"key": "EntryName", "value": "Vasoprsn_rcpt"}]}, {"database": "PANTHER", "id": "PTHR24241:SF161", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24241", "properties": [{"key": "EntryName", "value": "NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "PRINTS", "id": "PR00896", "properties": [{"key": "EntryName", "value": "VASOPRESSINR"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNQTIEKDLISDISKRDQTLANFEIAILSIIFILIVVGNVAVIIALVSARIKIQRMYYFLLHLSISDLLTAFCNVLPQLIWEITVRFYGDNFLCKFVKYIQLLGPYLSSYVLVFTAIDRYQSICFPLANCTWTERRSKIMITFAWIIALICCLPQAFIFSYVRIAWTTYPNSSSSYKILDKPDNKNDLYTVYYNECWGTFIKPWGEKIYVLWYAISVFFVPLIILSFTYFNICKVIWINARIKRKNMKESKSNLIFKKTKKFFKNNSNKNIENFKNSQDEEIVFLKDKYNVYKHNVLISSNSEKTLNNTKTKLSLFNARSNANANKLSKAKFKTIKVTLVVIICYISCSLPFCFVQLWAHWWPEAQSSSLWNGPLITITMLLPSLNSCVNPWIYLLLNRNLLYTLLNLIFGPKCVKNPIDGHLSTSIQKTTTYTDYSKANISNNVKLTEFNITNNNLVTIHYAKTTKIENELKVEFLIKNYVESNLIKKNQYLSRTKSEPNLSNKLMKNISISCSDSDLITIKR", "length": 524, "molWeight": 60871, "crc64": "0C93D6B63447A78C", "md5": "3B5AE03F9729E9755319E148F62A6561"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI00324433C8"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PAV3", "uniProtkbId": "A0AAU6PAV3_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20547.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20547.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00124"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20547.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20547.1"}], "value": "U_LCTX_10_Cm15", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20547.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480816", "properties": [{"key": "ProteinId", "value": "WXB20547.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0043195", "properties": [{"key": "GoTerm", "value": "C:terminal bouton"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030297", "properties": [{"key": "GoTerm", "value": "F:transmembrane receptor protein tyrosine kinase activator activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043410", "properties": [{"key": "GoTerm", "value": "P:positive regulation of MAPK cascade"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00112", "properties": [{"key": "EntryName", "value": "LDLa"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.128.620", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036055", "properties": [{"key": "EntryName", "value": "LDL_receptor-like_sf"}]}, {"database": "InterPro", "id": "IPR023415", "properties": [{"key": "EntryName", "value": "LDLR_class-A_CS"}]}, {"database": "InterPro", "id": "IPR002172", "properties": [{"key": "EntryName", "value": "LDrepeatLR_classA_rpt"}]}, {"database": "PANTHER", "id": "PTHR21105", "properties": [{"key": "EntryName", "value": "GH16255P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21105:SF0", "properties": [{"key": "EntryName", "value": "GH16255P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57424", "properties": [{"key": "EntryName", "value": "LDL receptor-like module"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01209", "properties": [{"key": "EntryName", "value": "LDLRA_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50068", "properties": [{"key": "EntryName", "value": "LDLRA_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "RLSRALVPLVQTYINMYKIWYFLFILSVIGTVFSDGPECPTVEGMERLACATKDEKGRYHCIDDFQICDGTRNCPNGEDEDPIACMYYKSIHSHLDVLADAMLEMSS", "length": 107, "molWeight": 12178, "crc64": "23C64E58F5F231BF", "md5": "EB663D2EE6C85BA58409A1E111F09433"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D27AEF"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHL3", "uniProtkbId": "A0AAN0LHL3_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34096.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34096.1"}], "value": "G protein-coupled receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 47, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 401, "modifier": "EXACT"}, "end": {"value": 422, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 434, "modifier": "EXACT"}, "end": {"value": 459, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 471, "modifier": "EXACT"}, "end": {"value": 492, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 513, "modifier": "EXACT"}, "end": {"value": 535, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 555, "modifier": "EXACT"}, "end": {"value": 581, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1200, "modifier": "EXACT"}, "end": {"value": 1224, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1244, "modifier": "EXACT"}, "end": {"value": 1264, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 413, "modifier": "EXACT"}, "end": {"value": 1257, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 721, "modifier": "EXACT"}, "end": {"value": 778, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 795, "modifier": "EXACT"}, "end": {"value": 833, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1082, "modifier": "EXACT"}, "end": {"value": 1102, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 228, "modifier": "EXACT"}, "end": {"value": 255, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 10, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 723, "modifier": "EXACT"}, "end": {"value": 738, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 761, "modifier": "EXACT"}, "end": {"value": 778, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 802, "modifier": "EXACT"}, "end": {"value": 833, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1089, "modifier": "EXACT"}, "end": {"value": 1102, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34096.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155022", "properties": [{"key": "ProteinId", "value": "WRW34096.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004989", "properties": [{"key": "GoTerm", "value": "F:octopamine receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "1.20.1070.10:FF:000248", "properties": [{"key": "EntryName", "value": "5-hydroxytryptamine receptor 1A-beta"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR002002", "properties": [{"key": "EntryName", "value": "Octopmn_rcpt"}]}, {"database": "PANTHER", "id": "PTHR24248", "properties": [{"key": "EntryName", "value": "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24248:SF174", "properties": [{"key": "EntryName", "value": "TYRAMINE_OCTOPAMINE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "PRINTS", "id": "PR00664", "properties": [{"key": "EntryName", "value": "OCTOPAMINER"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNYAAVNSINKPHPGRRRNSSSYSVKIKNKNFKNDLLIKFKHKNCSLFFNLKSYLFIFLLISSFSFSTQNSLKENLLTNQYSKEQNNIYRNLSENNLELKNGLNITINNLFYKKLNDLVKENDHLDNFYFLKNLIFFEKRDKNNSFKSKKLILKNNDLFSNFKDSFSKKLSIKDKKFLKSFIKYINEKPLNQSSKINIQSNEKFLSNTKIDENFKILNNLENYKVLNNKNIFENLTEIQNKIDELNKNSSKLYQKLSFELSQNKKYHKKDNKKFINDYYSNIENILKQKFLKNQRIINFNKLIFEKDKTVSSQNLFQTKNLVRTKKNQANNIFLEEDSKNYKILSIMSNNHSLIKNDTTIIFNESYIISKTDINSTTQLNFFELLQFYIPNITLEKLIICLAQVATMLFTIIGNILVIISIFTYNPLRNVQNMFLVSLAVSDITVAVCVLPLSAAYSLIDKWVFGIHLCKFWLTSDILCCTASILNLCAIAVDRYQAIHDPINYRMKRTLGRVLGTIVFVWVLSAITSIPPLLGWNDWPQEFSPDLPCRLTSQKGFIVFSSSVSFYIPLLIMTTVYIKIFLATKERLRKRAQGTAKMSFKNANKKSIPMNKNYIDEDQDKKLEEKNLRINNSGHNLIQNYLQDDSFNNKIFLITQVTDNKKNKKFDNSSIKGSIKNENKQKFSISEQKTSSSNEDSFVNLEYNCVDKNFISNKKINKEQLIKPNKKKTKSLNRNKIKRQSTPEEDSDSSDSVVEKEFSSSNAHDFSQKNLCKKVQPTSQKSIAKSFKTRFRNSIFSHHIKNPTPTATSSIPKSNSQISFKNNSSALSQMKRSQQNTRFGSFNLLKKYKSRFNKLNNSNFFNNFPSSPNKPKIGIVSATTTPELTFSSKNSSKEDHIAIFKENSTLFNDKVNNENDKNLNFMSKSVNNSFYNKNELKNKIPNKQQTGYLKSSIEAIYIQKSISITDLNLMKIYNEKLLKEKKNSDDKLNLNNFDVEINLKLDSNLQDKIKSSINKEDEIFMKKNNFKSDEALNFSSKQDDFTTSINNYNMDDYNQRCLSPTSMLQLPKRSIFEKNQQINQNELSNSKNQNSCSNDSNLNYNNSLTKQYTNSQRNHSSNSNYYSYTSTTSTSVLTTSQQHGQSCLDNTDLPLSSNSKSFSNKKSGSFKSSQINSSNMLSSSNMIKQAWEQKQRISLSKERKAAQVLGIVMGAFIACWLPFFLMYVIEPFCGEACAVNQFTQMFITWLGYINSTLNPIIYTIFNMDFRKAFKRIFMKCCCGVKFKQQQRLYQHQQLIKLNKRKEHKKNKMLHLHQKMNKKFEQEKTFENKDICKKVLIDEKERKNSINQLIAIDSSGYLRKISLSLDKNKLLDSNFIKNSSSCSKLDKLPEDTILYKKKIIDTICDMYLSISCENINSKLNKNNIDYKNIILKPISLPPFKKNLINKEEFNYLDKKCNFNKDKIVENDENTDSYDLNDLKQMILEKNLKQLENNADFCHFDFNDQIFTYFI", "length": 1508, "molWeight": 175431, "crc64": "15F6B2AF76430504", "md5": "14BA0F31102E348AAE8BF83560D6BE3F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 8, "Domain": 1, "Region": 4, "Coiled coil": 1, "Compositional bias": 5}, "uniParcId": "UPI003252251E"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJA3", "uniProtkbId": "A0AAU7LJA3_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28212.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28212.1"}], "value": "MADS17"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28212.1"}], "value": "MADS17"}}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28212.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28212.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400852", "properties": [{"key": "ProteinId", "value": "XBP28212.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNGGIFQLKQLAHKNYNKCILHFNNNFAHHFNERSIFGASSSNSLFYVKNSNIFANDFIFFHYENFCYEKFIFFILKIFTSTKGSITSLAWLFSLGFFDHEDLGWSLKTKYILDILKKINELLFINELTTLSGTKVGVVIFSPLGKPYSFAHPYVDSLANRFLNRNPPNNDITHAIVKAYKKFMLDETKQKHNKTLEKVELENERNKMVEIMNN", "length": 214, "molWeight": 25003, "crc64": "269619ADFFCC380D", "md5": "E70EC0626EAF421964F7C376C1211B5B"}, "extraAttributes": {"uniParcId": "UPI0035D2D161"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7YD65", "uniProtkbId": "A0AAU7YD65_NIDPL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Nidirana pleuraden", "commonName": "Yunnan pond frog", "synonyms": ["Babina pleuraden"], "taxonId": 369511, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87686.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Ranoidea", "Ranidae", "Nidirana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87686.1"}], "value": "Amplexin 12"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 101, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043571623"}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87686.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 101, "modifier": "EXACT"}, "end": {"value": 101, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87686.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "38891597", "citationType": "journal article", "authors": ["Zheng P.", "Gong Y.", "Wang B.", "Yu H.", "Huang S.", "Liao X.", "Jiang J.", "Ran J.", "Xie F."], "citationCrossReferences": [{"database": "PubMed", "id": "38891597"}], "title": "Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.", "publicationDate": "2024", "journal": "Animals (Basel)", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87686.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-E24AGF4876IHP", "citationType": "submission", "authors": ["Zheng P."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87686.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP623147", "properties": [{"key": "ProteinId", "value": "XBY87686.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR045860", "properties": [{"key": "EntryName", "value": "Snake_toxin-like_sf"}]}, {"database": "SUPFAM", "id": "SSF57302", "properties": [{"key": "EntryName", "value": "Snake toxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "SSKQSLQIINMKVMITLLILGLLLIHGETLQCFKTTSLGGIYYKYSKITCPRDTDQCYKLKKIYALQDEKELRCATREECQNLYLRNPFGECCATDFCNTI", "length": 101, "molWeight": 11642, "crc64": "C0D506AFBA12EDAD", "md5": "82653FF9E0417ADDC48712CD4CD7EE23"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D358F3"}, "cluster_size": 1, "family": "Ranidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN23", "uniProtkbId": "A0AA96MN23_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50078.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50078.1"}], "value": "Uncharacterized protein 16"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 171, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041675761"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50078.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460155", "properties": [{"key": "ProteinId", "value": "WNS50078.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSMILGKLLLIALAAMCSALPATDETRLHLSRSRRSTDYKFYYPDDNVCCPKVLPATDKSTSSVVQAFGGCQVQVAAITAFGSCNIKHEGFWWFIDWGNGEHDEGCTNDLGPFGPRVHQYKSCLKYHGLGYKGSTECVEVYYCSSPDSGHNKCTSNADCCDSFTHCIDVHY", "length": 171, "molWeight": 18887, "crc64": "10D5E24BC0B52095", "md5": "A5145186C98EFA49FAA3FF5E63A087FF"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B2D93FD"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8HY16", "uniProtkbId": "A0AAU8HY16_9TELE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Astyanax altiparanae", "taxonId": 142828, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71658.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Characiformes", "Characoidei", "Acestrorhamphidae", "Acestrorhamphinae", "Astyanax"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71658.1"}], "value": "20 beta-hydroxysteroid dehydrogenase"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71658.1"}], "value": "hsd20b"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004240"}], "value": "Endoplasmic reticulum", "id": "SL-0095"}}]}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71658.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 187, "modifier": "EXACT"}, "end": {"value": 187, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71658.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022955"}], "id": "KW-0444", "category": "Biological process", "name": "Lipid biosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022955"}], "id": "KW-0443", "category": "Biological process", "name": "Lipid metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022857"}], "id": "KW-0521", "category": "Ligand", "name": "NADP"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022955"}], "id": "KW-0752", "category": "Biological process", "name": "Steroid biosynthesis"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8QAMRIAJBPKUI", "citationType": "submission", "authors": ["Abreu M.R.", "Batlouni S.R."], "title": "Molecular and hormonal mechanisms underlying oocyte maturation and ovulation and its application to seed production in the lambari (Astyanax altiparanae).", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71658.1"}], "value": "Ovary", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71658.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP964776", "properties": [{"key": "ProteinId", "value": "XCI71658.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005783", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016491", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006694", "properties": [{"key": "GoTerm", "value": "P:steroid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd05356", "properties": [{"key": "EntryName", "value": "17beta-HSD1_like_SDR_c"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.50.720:FF:000137", "properties": [{"key": "EntryName", "value": "Hydroxysteroid (17-beta) dehydrogenase 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.720", "properties": [{"key": "EntryName", "value": "NAD(P)-binding Rossmann-like Domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036291", "properties": [{"key": "EntryName", "value": "NAD(P)-bd_dom_sf"}]}, {"database": "InterPro", "id": "IPR020904", "properties": [{"key": "EntryName", "value": "Sc_DH/Rdtase_CS"}]}, {"database": "InterPro", "id": "IPR002347", "properties": [{"key": "EntryName", "value": "SDR_fam"}]}, {"database": "InterPro", "id": "IPR051019", "properties": [{"key": "EntryName", "value": "VLCFA-Steroid_DH"}]}, {"database": "PANTHER", "id": "PTHR43899:SF10", "properties": [{"key": "EntryName", "value": "20BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43899", "properties": [{"key": "EntryName", "value": "RH59310P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00106", "properties": [{"key": "EntryName", "value": "adh_short"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF000126", "properties": [{"key": "EntryName", "value": "11-beta-HSD1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00081", "properties": [{"key": "EntryName", "value": "GDHRDH"}]}, {"database": "SUPFAM", "id": "SSF51735", "properties": [{"key": "EntryName", "value": "NAD(P)-binding Rossmann-fold domains"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00061", "properties": [{"key": "EntryName", "value": "ADH_SHORT"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VRKFGQWAVVTGATSGIGRAYALELARRGLDIVLISRSEEKLVHTAKEIESQYGRQTRVIQADFTGGESIYPDIAQQLKGLEIGILVNNVAMNYAEEFAHFLDVPDSEQRITQVINCNILSVTQMTRVILPHMVERGSGLIINLSSEAASKPQPMLALYSATKIFVTYFSRCLHSEYRSRGITVQCV", "length": 187, "molWeight": 20792, "crc64": "9C550FE266B3866B", "md5": "126AEB748749A4B24C4AB6578CE9AD82"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D3A24B"}, "cluster_size": 2, "family": "Acestrorhamphidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZED5", "uniProtkbId": "A0AB38ZED5_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71771.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71771.1"}], "value": "Venom redulysin 5"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 252, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044256845"}, {"type": "Coiled coil", "location": {"start": {"value": 92, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 211, "modifier": "EXACT"}, "end": {"value": 242, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 252, "modifier": "EXACT"}, "end": {"value": 252, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71771.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71771.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510846", "properties": [{"key": "ProteinId", "value": "WXH71771.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSKLWLLLLLVAAFQTAQSFPTNDDYLEDADTTVSILKDTWGKLKDMYTDKGKQMAKKILAKLKEKLCTQNDFEEDVDYAEEDGETIASKLLTKIRETMKKVKEAVGEKKEQFKQELEKLRVKFCNSQIEDVEEDEEEFFNDYEEEDGDTTASIMKDTLGKLKELYAEKTKEAAKKLLAILKEKLCTQNDYEEDVDYAEEDGEQMSSSKLVAKIKELIQQIKKAVGEEREKLKKQLEEFRVKLCNYQIEDVE", "length": 252, "molWeight": 29279, "crc64": "D4B4DFB7E22FD505", "md5": "CDFC75F6113808B786726D999C8A5485"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Coiled coil": 2, "Non-terminal residue": 1}, "uniParcId": "UPI00388BDC67"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHF8", "uniProtkbId": "A0AAN0LHF8_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34109.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00018873"}], "value": "Thyrotropin-releasing hormone receptor"}}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00032251"}], "value": "Thyroliberin receptor"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004100"}], "value": "Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004370"}], "value": "Membrane", "id": "SL-0162"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 53, "modifier": "EXACT"}, "end": {"value": 81, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 93, "modifier": "EXACT"}, "end": {"value": 112, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 179, "modifier": "EXACT"}, "end": {"value": 196, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 208, "modifier": "EXACT"}, "end": {"value": 226, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 324, "modifier": "EXACT"}, "end": {"value": 344, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 356, "modifier": "EXACT"}, "end": {"value": 380, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 73, "modifier": "EXACT"}, "end": {"value": 377, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34109.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155035", "properties": [{"key": "ProteinId", "value": "WRW34109.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004997", "properties": [{"key": "GoTerm", "value": "F:thyrotropin-releasing hormone receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR002120", "properties": [{"key": "EntryName", "value": "TRH_rcpt_1"}]}, {"database": "PANTHER", "id": "PTHR46061", "properties": [{"key": "EntryName", "value": "THYROTROPIN-RELEASING HORMONE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46061:SF3", "properties": [{"key": "EntryName", "value": "THYROTROPIN-RELEASING HORMONE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNLSLIEKNLELNFSDKMYELLCVLNETDLKILNKETLIQFYEFCSSQPYYPFLYQVIGSLILSLIGIIGVLGNLMVIYVVFYIKSMQTPTNFYLASLAVADLLVLLSTIPFEITSSFIKSDAWLLGELACKLTIYVQYMSINGSAANIAAFTYERYTAICHPIKTQTFNKLQRAKKRILTIWIFVVNYNLSWFFITSVKKDPKKNTQHYLCIFYIIPLILSFYMYTKIIKVLFKSSNFTNKSNIQNKSSISRSDQTDEFKNNEINLVQNPLNKDVTTVKSSFDKDEKKNKLIFMVKKQKTGQSNRRISNLSSQNFKTKQVVKLLILILSLFAILWLPYRLLVVYNSLVKEQYLDIWFLLFCKSLVFINSAINPILYNFISKKFRYQYKICLGYIFKKKKKFKTNSTKSKPSFQSQF", "length": 417, "molWeight": 48718, "crc64": "65C541948CDBD6D2", "md5": "02E64640C2B8913D28438366665BCDB6"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6, "Domain": 1}, "uniParcId": "UPI00324E3728"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39J8M0", "uniProtkbId": "A0AB39J8M0_SALZA", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Salacca zalacca", "commonName": "Snake palm", "synonyms": ["Salacca edulis"], "taxonId": 145711, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89004.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Liliopsida", "Arecaceae", "Calamoideae", "Calameae", "Salaccinae", "Salacca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89004.1"}], "value": "Uncharacterized protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89004.1"}], "value": "LOC114914179"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 193, "modifier": "EXACT"}, "end": {"value": 193, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89004.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9V2V54QP4C7C3", "citationType": "submission", "authors": ["Tong W."], "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89004.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ120712", "properties": [{"key": "ProteinId", "value": "XDN89004.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MGELKPTLRRPNEEPCMDTLDIMMDHEIDIMDELEGAWDIGYDEHEWDFMAWRQSQCKVSQDGGDEMNTHRSFNDEFTVKGENAGFWEARSTFSLNLNLNYQEVIDAWSERGPLWVEDRSISSAANARLVSKQLVCFLNVLKNLIFDISFNCLDNAKHYYKIVWLYDGWRNEWNISFFFKKKKWCMPFVLLYF", "length": 193, "molWeight": 22984, "crc64": "64C3365021FEE0A1", "md5": "8674F25314D8FAAA88F4B2FE66B61480"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI00388BE64E"}, "cluster_size": 1, "family": "Arecaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38Z7S2", "uniProtkbId": "A0AB38Z7S2_PAESU", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Paeonia suffruticosa", "commonName": "Tree peony", "synonyms": ["Paeonia moutan"], "taxonId": 45171, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20336.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20336.1"}], "value": "SKP1 family"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00054396"}], "value": "Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1"}], "commentType": "FUNCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004906"}], "value": "Protein modification; protein ubiquitination"}], "commentType": "PATHWAY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011621"}], "value": "Part of a SCF (SKP1-cullin-F-box) protein ligase complex"}], "commentType": "SUBUNIT"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009993"}], "value": "Belongs to the SKP1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 467, "modifier": "EXACT"}, "end": {"value": 486, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 125, "modifier": "EXACT"}}, "description": "SKP1 component POZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03931"}]}, {"type": "Domain", "location": {"start": {"value": 162, "modifier": "EXACT"}, "end": {"value": 200, "modifier": "EXACT"}}, "description": "SKP1 component dimerisation", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01466"}]}, {"type": "Region", "location": {"start": {"value": 229, "modifier": "EXACT"}, "end": {"value": 255, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 321, "modifier": "EXACT"}, "end": {"value": 355, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 323, "modifier": "EXACT"}, "end": {"value": 334, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022786"}], "id": "KW-0833", "category": "Biological process", "name": "Ubl conjugation pathway"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-67NUCHPS7RPVN", "citationType": "submission", "authors": ["Zhang Y.", "Gai S."], "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20336.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR237921", "properties": [{"key": "ProteinId", "value": "WRI20336.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0009867", "properties": [{"key": "GoTerm", "value": "P:jasmonic acid mediated signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0006511", "properties": [{"key": "GoTerm", "value": "P:ubiquitin-dependent protein catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.30.710.10:FF:000022", "properties": [{"key": "EntryName", "value": "SKP1-like protein 21 isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.710.10", "properties": [{"key": "EntryName", "value": "Potassium Channel Kv1.1, Chain A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR016897", "properties": [{"key": "EntryName", "value": "SKP1"}]}, {"database": "InterPro", "id": "IPR001232", "properties": [{"key": "EntryName", "value": "SKP1-like"}]}, {"database": "InterPro", "id": "IPR036296", "properties": [{"key": "EntryName", "value": "SKP1-like_dim_sf"}]}, {"database": "InterPro", "id": "IPR011333", "properties": [{"key": "EntryName", "value": "SKP1/BTB/POZ_sf"}]}, {"database": "InterPro", "id": "IPR016072", "properties": [{"key": "EntryName", "value": "Skp1_comp_dimer"}]}, {"database": "InterPro", "id": "IPR016073", "properties": [{"key": "EntryName", "value": "Skp1_comp_POZ"}]}, {"database": "PANTHER", "id": "PTHR11165", "properties": [{"key": "EntryName", "value": "SKP1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01466", "properties": [{"key": "EntryName", "value": "Skp1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03931", "properties": [{"key": "EntryName", "value": "Skp1_POZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00512", "properties": [{"key": "EntryName", "value": "Skp1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54695", "properties": [{"key": "EntryName", "value": "POZ domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81382", "properties": [{"key": "EntryName", "value": "Skp1 dimerisation domain-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQNLGQKNASEPLLGSLRKLPGYCKELQTHTQREEHSHFLVQNYCQMSEVSMAVIKPEMMKTYIWLQTTDGSIQEVEQEVAMFCPIISQEINKGMGSSKNYPISLPQRVSPAMLSLILDYCRFHQVPGRSNKEHKSFDEKFIRTDTKRLCELASAADSLKLKPLVDLTSRALARVIEGKTPEEIREIFHLPDDLTEEEKLEPMKNTTNDPQIRLLNRLNAKKRKQLKEREKLKNVDVEESVDDHSVDDRSEDPRASYKKVGALLRSEQAHLLMRWVPRCTGFDDLTPHLPDNSLRISDHSHRYKASLGCVWSRWKSVNEGVKTSKHKKKNRKRKDQQQRPACSNEAHKEESNGVNSVCHNEMDGKFIPTDLSRLQDVGDTTFIEFDDGDIDDEIDPELKEKIDREVEDFARRLNSDWPERMQEILSLGQERGPVSTSINGNGSLGRYAKNEFFFFPVEIFGRLSSSLTLFFNFSSFLTLFFHLMWFRYFYTTRIEPEALILAISKISSATTLLIKRRRKCGPKGKPWASGAPIRGRVVYNEKYKLRKSFVLEGKEMVQREGEEEIKVNKTRYGWVGRGVEPIGGDFHNLGKTFVFFFFEKDRFDKVPDDDGVPSIPSPFQRVELEFCFTCYIVHS", "length": 635, "molWeight": 73370, "crc64": "781C67CB5D26DA0F", "md5": "43264F25A1737D0530FD5C5DB0ECFBD6"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "PATHWAY": 1, "SUBUNIT": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 2, "Region": 2, "Compositional bias": 1}, "uniParcId": "UPI00388C2E96"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI76", "uniProtkbId": "A0AA96MI76_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50084.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50084.1"}], "value": "Serine protease HTRA1A-like protein"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 164, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041660961"}, {"type": "Domain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 87, "modifier": "EXACT"}}, "description": "IGFBP N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51323"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50084.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50084.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50084.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460161", "properties": [{"key": "ProteinId", "value": "WNS50084.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008233", "properties": [{"key": "GoTerm", "value": "F:peptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "4.10.40.20", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009030", "properties": [{"key": "EntryName", "value": "Growth_fac_rcpt_cys_sf"}]}, {"database": "InterPro", "id": "IPR000867", "properties": [{"key": "EntryName", "value": "IGFBP-like"}]}, {"database": "InterPro", "id": "IPR017891", "properties": [{"key": "EntryName", "value": "Insulin_GF-bd_Cys-rich_CS"}]}, {"database": "Pfam", "id": "PF00219", "properties": [{"key": "EntryName", "value": "IGFBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57184", "properties": [{"key": "EntryName", "value": "Growth factor receptor domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00222", "properties": [{"key": "EntryName", "value": "IGFBP_N_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51323", "properties": [{"key": "EntryName", "value": "IGFBP_N_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLLSLLAVLLSAQLCRATGCGQPSQCVAHLCPQPKYCPLGATTEPCGCCKVCLKKEGELCGGPDGACGLGFTCNTTGGAITGKCQRLAGCHLYNSYLAVGTAVQWGECSECECVKDRDLHCRRNMTKCSAVRHDDTPVKNAFPELNYIENTPVDMQDNHEPLLP", "length": 164, "molWeight": 17553, "crc64": "AAADFBDF053A49F1", "md5": "846CE278565BDEF3BF02477A73AEFB36"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B2B6DF2"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0MTA5", "uniProtkbId": "A0AAU0MTA5_UREUN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Urechis unicinctus", "commonName": "Fat innkeeper worm", "synonyms": ["Chinese penis fish"], "taxonId": 6432, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59947.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Echiura", "Xenopneusta", "Urechidae", "Urechis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59947.1"}], "value": "Heat shock protein family A member 12 variant X8"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59947.1"}], "value": "HSPA12"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007381"}], "value": "Belongs to the heat shock protein 70 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59947.1"}], "id": "KW-0346", "category": "Biological process", "name": "Stress response"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FQL9M4QGPVUS3", "citationType": "submission", "authors": ["Liu D.D."], "publicationDate": "FEB-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59947.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OM803168", "properties": [{"key": "ProteinId", "value": "WOS59947.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0140662", "properties": [{"key": "GoTerm", "value": "F:ATP-dependent protein folding chaperone"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd10229", "properties": [{"key": "EntryName", "value": "ASKHA_NBD_HSP70_HSPA12"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR043129", "properties": [{"key": "EntryName", "value": "ATPase_NBD"}]}, {"database": "InterPro", "id": "IPR018181", "properties": [{"key": "EntryName", "value": "Heat_shock_70_CS"}]}, {"database": "InterPro", "id": "IPR013126", "properties": [{"key": "EntryName", "value": "Hsp_70_fam"}]}, {"database": "PANTHER", "id": "PTHR14187", "properties": [{"key": "EntryName", "value": "ALPHA KINASE/ELONGATION FACTOR 2 KINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14187:SF5", "properties": [{"key": "EntryName", "value": "HEAT SHOCK 70 KDA PROTEIN 12A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00012", "properties": [{"key": "EntryName", "value": "HSP70"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53067", "properties": [{"key": "EntryName", "value": "Actin-like ATPase domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS00297", "properties": [{"key": "EntryName", "value": "HSP70_1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDQPYVMVAAIDLGTTYSGYTFSTTYDQNTIYSFNKWGTSVNIPFSQKTPTCLLTDQNLQFVAMGYEAQRQYKEMDDEILNFRYFEGFKMSLHLDKNINQDSVIQDSTGLSCPALDIFAMMLRELGNHLMEQVKCRVDSVPTNCQIRWVVTVPAIWTDAAKQFMRMAAVKAGLVDIPKADNLLIALEPEVASMYCAKLPLKEFPSSPTTHEFKEGLKYVVIDAGGGTLDVTVHELLTGGGLTELHCANGGAMGAHKVNVRFIEVLRRVFKHHDFIDKCRSESPGVFLDLQCSFETIKRSVDPEKKNSALIPINMELSDLHRELYGESIVKSITPDYQKQGVRIRSGMLTLPYSVLLDIFSPVVDDVVTYVCNLLTKPELDGVETVLLVGGFSDCVLLQKSLRQALRSDLAILIPNDAWSAVLKGAVMFGHDPTWIRGRKSQRTYGIAGMVTFNPLYHRLSQRITLNERELVRNAFVMLIQKGEPLRSITKRCKPAAYNTKLMEFKIYATPKKIPTFVDDAESVMVAMVTVELEGCGIDREVEVEVKFDGPETGIAARDISGKGQVVKADINFLRQ", "length": 575, "molWeight": 64362, "crc64": "67EF1524FBAFF9DB", "md5": "2583A75D96E48199764B87C7D5B53AB6"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0035D332A8"}, "cluster_size": 2, "family": "Urechidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEH5", "uniProtkbId": "A0AB38ZEH5_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02684.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "value": "Metalloendopeptidase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "value": "3.4.24.-"}]}}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Zn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29105"}}], "note": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "value": "Binds 1 zinc ion per subunit."}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 264, "modifier": "EXACT"}}, "description": "Metalloendopeptidase", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "featureId": "PRO_5044047224"}, {"type": "Domain", "location": {"start": {"value": 62, "modifier": "EXACT"}, "end": {"value": 264, "modifier": "EXACT"}}, "description": "Peptidase M12A", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51864"}]}, {"type": "Active site", "location": {"start": {"value": 162, "modifier": "EXACT"}, "end": {"value": 162, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}]}, {"type": "Binding site", "location": {"start": {"value": 161, "modifier": "EXACT"}, "end": {"value": 161, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 165, "modifier": "EXACT"}, "end": {"value": 165, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 171, "modifier": "EXACT"}, "end": {"value": 171, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105", "note": "catalytic"}}, {"type": "Disulfide bond", "location": {"start": {"value": 130, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023049"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0482", "category": "Molecular function", "name": "Metalloprotease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361183"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01211"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02684.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517434", "properties": [{"key": "ProteinId", "value": "WXI02684.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004222", "properties": [{"key": "GoTerm", "value": "F:metalloendopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd04280", "properties": [{"key": "EntryName", "value": "ZnMc_astacin_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.390.10", "properties": [{"key": "EntryName", "value": "Collagenase (Catalytic Domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR034035", "properties": [{"key": "EntryName", "value": "Astacin-like_dom"}]}, {"database": "InterPro", "id": "IPR024079", "properties": [{"key": "EntryName", "value": "MetalloPept_cat_dom_sf"}]}, {"database": "InterPro", "id": "IPR001506", "properties": [{"key": "EntryName", "value": "Peptidase_M12A"}]}, {"database": "InterPro", "id": "IPR006026", "properties": [{"key": "EntryName", "value": "Peptidase_Metallo"}]}, {"database": "PANTHER", "id": "PTHR10127", "properties": [{"key": "EntryName", "value": "DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10127:SF780", "properties": [{"key": "EntryName", "value": "METALLOENDOPEPTIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01400", "properties": [{"key": "EntryName", "value": "Astacin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00480", "properties": [{"key": "EntryName", "value": "ASTACIN"}]}, {"database": "SMART", "id": "SM00235", "properties": [{"key": "EntryName", "value": "ZnMc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55486", "properties": [{"key": "EntryName", "value": "Metalloproteases ('zincins'), catalytic domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51864", "properties": [{"key": "EntryName", "value": "ASTACIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTMWSLIVLLFLGSAYSRRLPKLDVQCDKNECVVVGDLMELPDEMIREGDIIADLDLELSRNAFIDKKRRWPQGIVPYVFHNKYSLAERNRIEEAMKGIEAKTCVKFEPMAKVQGAEQTGYVMILPNEGCKSNLGYWATRGQSILSLNPLACLPKLGVIQHELLHVLGLKHEHARPDRDLYVDIVKENIQQSHMQNFWKADEVEFTTYDIPYNYESVMHYKSDAFSKNGKPTIVAKNGEGTAKMGQRKRAHDLDLQKINKMYCS", "length": 264, "molWeight": 30282, "crc64": "326EA6668B1DE61A", "md5": "D5E90211AEF4D9FE3CEF9DBEC132111A"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Active site": 1, "Binding site": 3, "Disulfide bond": 1}, "uniParcId": "UPI00388C2E2C"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA86IX53", "uniProtkbId": "A0AA86IX53_SPOLT", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Spodoptera litura", "commonName": "Asian cotton leafworm", "taxonId": 69820, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDU47018.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Amphipyrinae", "Spodoptera"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDU47018.1"}], "value": "Protein doublesex"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00070"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 35, "modifier": "EXACT"}}, "description": "DM", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50809"}]}, {"type": "DNA binding", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 35, "modifier": "EXACT"}}, "description": "DM", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00070"}]}, {"type": "Region", "location": {"start": {"value": 58, "modifier": "EXACT"}, "end": {"value": 93, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 58, "modifier": "EXACT"}, "end": {"value": 75, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDU47018.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00070"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00070"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00070"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00070"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4HN0Q4T1FF4A", "citationType": "submission", "authors": ["Nagamine K.", "Kanno Y.", "Sahara K.", "Fukushi M.", "Ishikawa Y.", "Terao M.", "Kageyama D.", "Shintani Y."], "title": "A novel segmented RNA virus that induces male killing in a noctuid moth.", "publicationDate": "NOV-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDU47018.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC740464", "properties": [{"key": "ProteinId", "value": "BDU47018.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007548", "properties": [{"key": "GoTerm", "value": "P:sex differentiation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "4.10.1040.10", "properties": [{"key": "EntryName", "value": "DM DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.8.10", "properties": [{"key": "EntryName", "value": "DNA helicase RuvA subunit, C-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001275", "properties": [{"key": "EntryName", "value": "DM_DNA-bd"}]}, {"database": "InterPro", "id": "IPR036407", "properties": [{"key": "EntryName", "value": "DM_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR026607", "properties": [{"key": "EntryName", "value": "DMRT"}]}, {"database": "InterPro", "id": "IPR014932", "properties": [{"key": "EntryName", "value": "DSX_dimer"}]}, {"database": "PANTHER", "id": "PTHR12322", "properties": [{"key": "EntryName", "value": "DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12322:SF116", "properties": [{"key": "EntryName", "value": "DOUBLESEX-MAB RELATED 99B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00751", "properties": [{"key": "EntryName", "value": "DM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08828", "properties": [{"key": "EntryName", "value": "DSX_dimer"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00301", "properties": [{"key": "EntryName", "value": "DM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01143", "properties": [{"key": "EntryName", "value": "DSX_dimer"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF82927", "properties": [{"key": "EntryName", "value": "Cysteine-rich DNA binding domain, (DM domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50809", "properties": [{"key": "EntryName", "value": "DM_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "KGHKRYCKYRNCTCEKCILTADRQRVMAQQTAMRRAQAQDEARARAGMQALGVELEQPEPPVVKAPRSPVVPPPRSLGSASCDSVPGSPGVSPYAPLPPSIPLPQAMPPLLPPQQPAVSLENLVDNCNKLLEKFHYSWEMMPLVLVILNYAGSDVDEASRKIDEGRMIINEYARKNNLNVFDGLELRDSTRQKMAEINNISGVLSSSMKLFCE", "length": 213, "molWeight": 23589, "crc64": "D8DEA09096BF8107", "md5": "2407A7634B02DE260605C888A146977B"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "DNA binding": 1, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI002B2EC626"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFU0", "uniProtkbId": "A0AAU7VFU0_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67478.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67478.1"}], "value": "Tudor domain protein 1"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67478.1"}], "value": "tudor1"}}], "features": [{"type": "Domain", "location": {"start": {"value": 57, "modifier": "EXACT"}, "end": {"value": 122, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 256, "modifier": "EXACT"}, "end": {"value": 320, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 777, "modifier": "EXACT"}, "end": {"value": 835, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1007, "modifier": "EXACT"}, "end": {"value": 1067, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1167, "modifier": "EXACT"}, "end": {"value": 1167, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67478.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67478.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67478.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750683", "properties": [{"key": "ProteinId", "value": "XBW67478.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "FunFam", "id": "2.30.30.140:FF:000018", "properties": [{"key": "EntryName", "value": "Serine/threonine-protein kinase 31"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "Gene3D", "id": "2.40.50.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR035437", "properties": [{"key": "EntryName", "value": "SNase_OB-fold_sf"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR050621", "properties": [{"key": "EntryName", "value": "Tudor_domain_containing"}]}, {"database": "PANTHER", "id": "PTHR22948:SF29", "properties": [{"key": "EntryName", "value": "FI02030P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22948", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "PROSITE", "id": "PS50304", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "4"}]}], "sequence": {"value": "MYKKGDKLLLYITFVNPACRAGRCEFWAQPSLETSQYALLERMIAAYDPASRPRVQEVEVGDVVLARYAADNNWYRVQVIQKIPSAVSHQPSSAKVQFLDFGNMEAVLLSDIVLPDIAISGIPPFAENFLAEGIKPADGQEWSNTDLQYINCNLVNFEFSAEILSPGTVGLQPSVMLTLSPKMVEQLAVSAPGALPPVPPVISLEAGQCYEVVIVQVTSPLGFSVHLVGNVSELENMNKQVLTKVASSAERFTVEQVYVGLVCAARRTGSVVQRAIITGIILLGDGSASPQYIITYLDYGDSASVTLSDLFPMSNDLAALCMIPAQAVLCCISNKPADSALFQQFVNRRRVFARCRGATPSGRHLMELYADASMVGQLSRGPSLSAALAALYQGAVASIPPGFRPPVGVPPGMAGRGMHRAPGFDGYAPVMPGVSRGAAILQNLARPPGLATTGPHCQPLIVPNLGMPPRIVASVAPYQNMPHGMDSSLALQNSMSSSMHSGLGLLQSVPPGQVSVEPLTFKSFLLSPGAQIDVCISSIEMNASFYIQLLPNARQLDNLLREINGNTAGYQAIAVGALAPGSACLVSQHSDGLVYRGRVLNDTTVMLIDFGRRLDVGRGEGSLLTGVNRYLDMPVQAAHCKLAELSERCSPSVVVNVLQQYDSKTALSALIDSVTQGPDPLYTVRLVHTGARDDIDINLSELIRLSAGSDAAVPPPPRFNPGKPEAVTVCLVQAGGQSGNFELFAQLNCYPVEKLTKFQEHLNAVYSREKIPGLLDGTQEGRYCVCRYDVDGQYYRGKVSRKVGGQFLVDFIDFGGQSIYDILSIKVLLSQFSVLCHQGVRMLLDLGGIQADLAQIKEVAADKVLVVIPLGPADNDVYKVHLPTDQPANQDFLSALRSIVPSRPQISSNLPTQIRQVSSSCVTPPYETKVAPSNISNSSHAPLQPFPLDEIKVGVWLDCYVTHVDDPECFYVQFSGAGAVEDKLTGIMDEIQTHVHALPPGSALRRPLGLRTAVLAKFADDGSWYRATVTGMLKGGDQFEVHFIDYGNRGVVGREEMRDITPTLTAYPTQSLPCSLQGINRQGGEAAWSSDDVSRFQGLLSDSDKSYKLFWSGQKDREGRRLVHLLDGQENINRSFLRETRKLSSDYTSPVVLAEAHHPPVMHSSPI", "length": 1167, "molWeight": 126132, "crc64": "B991777E0D832FDB", "md5": "C51BD8CE6174B307BDE0264888445674"}, "extraAttributes": {"countByFeatureType": {"Domain": 4, "Non-terminal residue": 1}, "uniParcId": "UPI0035D28E53"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMS4", "uniProtkbId": "A0AAU0QMS4_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56534.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56534.1"}], "value": "Ionotropic receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 36, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 56, "modifier": "EXACT"}, "end": {"value": 75, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 87, "modifier": "EXACT"}, "end": {"value": 114, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 125, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00060"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56534.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56534.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56534.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970334", "properties": [{"key": "ProteinId", "value": "WPO56534.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0050906", "properties": [{"key": "GoTerm", "value": "P:detection of stimulus involved in sensory perception"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR052192", "properties": [{"key": "EntryName", "value": "Insect_Ionotropic_Sensory_Rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "PANTHER", "id": "PTHR42643", "properties": [{"key": "EntryName", "value": "IONOTROPIC RECEPTOR 20A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR42643:SF24", "properties": [{"key": "EntryName", "value": "IONOTROPIC RECEPTOR 60A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSTALPRYRAILGPFHWHVWVALTFTYLIGIFPLAFSDKHTLRHLLHNSGEIENMFWYVFGTFTNCFTFFGKNSWSKTTKITTRLLIGWYWIFTIIITSCYTGSIIAFVTLPVFPETVDTIQQLLAGFYRVGTLGKLNYNISIIKVVGYLFHTDEVL", "length": 157, "molWeight": 18175, "crc64": "0C6C7B0C9C2BEFFF", "md5": "43D634049A9A9208156244E80296AC2C"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 3, "Domain": 1}, "uniParcId": "UPI00308C56B3"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NFJ2", "uniProtkbId": "A0AA96NFJ2_9MAGN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Corydalis yanhusuo", "taxonId": 458692, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT44092.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Ranunculales", "Papaveraceae", "Fumarioideae", "Corydalis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT44092.1"}], "value": "CYP82BE1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004913"}], "value": "Alkaloid biosynthesis"}], "commentType": "PATHWAY"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004370"}], "value": "Membrane", "id": "SL-0162"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 41, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 323, "modifier": "EXACT"}, "end": {"value": 346, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 469, "modifier": "EXACT"}, "end": {"value": 469, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7U5ELI1R3HKK0", "citationType": "submission", "authors": ["Liu X."], "publicationDate": "FEB-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT44092.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ434214", "properties": [{"key": "ProteinId", "value": "WNT44092.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0033075", "properties": [{"key": "GoTerm", "value": "P:isoquinoline alkaloid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000026", "properties": [{"key": "EntryName", "value": "Cytochrome P450 82C4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050651", "properties": [{"key": "EntryName", "value": "Plant_Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR47947:SF26", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47947", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 82C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MESYSSLPFLHKWPLSSISSSPTSIAATLLIVACFTIVFLYRITTTNSRSKHNDLKAPPKYPGAWPLMGHLRLFGGSNPAHVTLANMAEKYGSTPFMIRFGQWPTLVVSSSDTVKECFNNTNDKLFSNRTITRGIRDMFYDMNAFGFASYGSYWRELRKVLVLTLLSPSRVDSVIQLKAPQFNGWFKKLYEECTNKKSGIVEMKSWLEVMMFNVLASMVVLPKDEGSIEKFRPVLAESVEVMGKMCIDDLIPRLGWLDHFTGLVKQCKVTGKKLDTILNSWLEDHRDEKVADEEKGMIGKLLSMKEGSKLLGHEGDTAVKANILGLLLGAGDSAGSTLTWAIVLLLNHPRMMERLREELDSVVGKHRQVEDADVKNFTYLQAILKETMRLYPVATILLRETPEDCVVAGCHIAAGTRLMVNVWQVQRDPNVWSDPLEFKPDRFQMESAHVDFSGQYSELIPFGTGRRMCPAITLSVRVMLLTLARLIHSFDMKIPNGESSVDTSIMTVGVGFGNLKLTPLEIELLPRLDSKIYG", "length": 534, "molWeight": 59958, "crc64": "10AE791856CB95B7", "md5": "FB74881078518F330377FCAB2FF7E4CF"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "PATHWAY": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 2, "Binding site": 1}, "uniParcId": "UPI002B323C67"}, "cluster_size": 1, "family": "Papaveraceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96RP16", "uniProtkbId": "A0AA96RP16_9BRYO", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Syntrichia caninervis", "taxonId": 200751, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNR61832.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Bryophyta", "Bryophytina", "Bryopsida", "Dicranidae", "Pottiales", "Pottiaceae", "Syntrichia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNR61832.1"}], "value": "ABI4-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00024343"}], "value": "Belongs to the AP2/ERF transcription factor family. ERF subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "AP2/ERF", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51032"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 68, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 372, "modifier": "EXACT"}, "end": {"value": 415, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 14, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 28, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 41, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 372, "modifier": "EXACT"}, "end": {"value": 388, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 389, "modifier": "EXACT"}, "end": {"value": 399, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 401, "modifier": "EXACT"}, "end": {"value": 415, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023016"}], "id": "KW-0346", "category": "Biological process", "name": "Stress response"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "33277766", "citationType": "journal article", "authors": ["Silva A.T.", "Gao B.", "Fisher K.M.", "Mishler B.D.", "Ekwealor J.T.B.", "Stark L.R.", "Li X.", "Zhang D.", "Bowker M.A.", "Brinda J.C.", "Coe K.K.", "Oliver M.J."], "citationCrossReferences": [{"database": "PubMed", "id": "33277766"}], "title": "To dry perchance to live: Insights from the genome of the desiccation-tolerant biocrust moss Syntrichia caninervis.", "publicationDate": "2021", "journal": "Plant J.", "firstPage": "1339", "lastPage": "1356", "volume": "105"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNR61832.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-9DVL6LOVVVJAN", "citationType": "submission", "authors": ["Liu D.", "Yang R.", "Liang Y.", "Zhang D."], "publicationDate": "APR-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNR61832.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON398261", "properties": [{"key": "ProteinId", "value": "WNR61832.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00018", "properties": [{"key": "EntryName", "value": "AP2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.730.10:FF:000001", "properties": [{"key": "EntryName", "value": "Ethylene-responsive transcription factor 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.730.10", "properties": [{"key": "EntryName", "value": "AP2/ERF domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001471", "properties": [{"key": "EntryName", "value": "AP2/ERF_dom"}]}, {"database": "InterPro", "id": "IPR036955", "properties": [{"key": "EntryName", "value": "AP2/ERF_dom_sf"}]}, {"database": "InterPro", "id": "IPR016177", "properties": [{"key": "EntryName", "value": "DNA-bd_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR31241", "properties": [{"key": "EntryName", "value": "DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31241:SF62", "properties": [{"key": "EntryName", "value": "DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00847", "properties": [{"key": "EntryName", "value": "AP2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00367", "properties": [{"key": "EntryName", "value": "ETHRSPELEMNT"}]}, {"database": "SMART", "id": "SM00380", "properties": [{"key": "EntryName", "value": "AP2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54171", "properties": [{"key": "EntryName", "value": "DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51032", "properties": [{"key": "EntryName", "value": "AP2_ERF"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MESKVEEPESKVEEPESGVSSETSSSDVDSCKATGKGGKKREREAATESGERVRRRRGGPENGLHQYRGVRQRQWGRWVAEIREPRLRTRMWLGTFGTALEAARAYDEAALVYHGPGARLNLPHETYQQQQQQRGACSGNSSCHFVQNSRQQQNSSGSATGMCYGTGTGYLQWSTEACHDRAARMDAASTAIPSFGGEALLRSASCNVGSDRQHQLFSPQVPSNYQRLSSCKLAPDRPSFGVLSSTDSGLFYAPRGLGLRSPLIECELGADCPFANRTHPQQQQQHRVADLHSTPVAPVQFAEFPVQPTYPGVDTASGHFVPHQPPEESCQNCSGCLEKVDYEGSAESSFELAEPDLGGFCFETELQAMATTSNSTDVSPVSSSITTSEHGGSPTSFWPDSTASTKPSPEESSSSFLWNTFPESQSFLMKPCDMNDVCWDDVDDVSIPILPPPSLFEFPDLPNLPFDSLADVFCDTPKAAV", "length": 481, "molWeight": 52400, "crc64": "810E3F784E69CE2B", "md5": "5F13C9635D2CD6EE5D70C6F6E9044856"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Region": 2, "Compositional bias": 6}, "uniParcId": "UPI002B2B20A3"}, "cluster_size": 1, "family": "Pottiaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHM9", "uniProtkbId": "A0AAQ5BHM9_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519482.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363122"}], "value": "Secretory carrier-associated membrane protein"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363122"}], "value": "Secretory carrier membrane protein"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519482.1"}], "value": "SCAMP3"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363122"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363122"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363122"}], "value": "Belongs to the SCAMP family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 92, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 49, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHM9"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHM9"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363122"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519482.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519482.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519482.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519482.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL713999", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "RefSeq", "id": "XP_016855480.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_016999991.1"}]}, {"database": "SMR", "id": "A0AAQ5BHM9", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000478737.6", "properties": [{"key": "ProteinId", "value": "ENSP00000519482.1"}, {"key": "GeneId", "value": "ENSG00000116521.12"}]}, {"database": "CTD", "id": "10067", "properties": [{"key": "Description", "value": "-"}]}, {"database": "HGNC", "id": "HGNC:10565", "properties": [{"key": "GeneName", "value": "SCAMP3"}]}, {"database": "OpenTargets", "id": "ENSG00000116521", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000160917", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015031", "properties": [{"key": "GoTerm", "value": "P:protein transport"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR007273", "properties": [{"key": "EntryName", "value": "SCAMP"}]}, {"database": "PANTHER", "id": "PTHR10687:SF6", "properties": [{"key": "EntryName", "value": "SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10687", "properties": [{"key": "EntryName", "value": "SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF04144", "properties": [{"key": "EntryName", "value": "SCAMP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAQSRDGGNPFAEPSELDNPFQDPAVIQHRPSRQYATLDVYNPFETREPPPAYEPPAPAPLPPPSAPSLQPSRKLSPTEPKNYGSYSTQASAAAATAELLKKQEELNRKAEELDRRERELQHAALGGTATRQNNWPPLPSFCPVQPCFFQDISMEIPQEFQKTVSTMYYLWMLAGSLLWWCRRATQQYPCSCCWSPCSSLALLC", "length": 204, "molWeight": 22919, "crc64": "4D4CD03962B17822", "md5": "8974694AFA53425E1FF4DC76CC19A0D3"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Region": 1, "Coiled coil": 1, "Compositional bias": 1}, "uniParcId": "UPI0007DC5BE2"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HCE2", "uniProtkbId": "A0AA96HCE2_9ANNE", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Melinna maculata", "taxonId": 2019425, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25261.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Sedentaria", "Canalipalpata", "Terebellida", "Terebelliformia", "Melinnidae", "Melinna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25261.1"}], "value": "Hypoxia-inducible factor 1"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Domain", "location": {"start": {"value": 88, "modifier": "EXACT"}, "end": {"value": 155, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 243, "modifier": "EXACT"}, "end": {"value": 294, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 13, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 370, "modifier": "EXACT"}, "end": {"value": 370, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25261.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25261.1"}], "value": "Melin1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25261.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354996", "properties": [{"key": "ProteinId", "value": "WNN25261.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005667", "properties": [{"key": "GoTerm", "value": "C:transcription regulator complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd11433", "properties": [{"key": "EntryName", "value": "bHLH-PAS_HIF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "4.10.280.10", "properties": [{"key": "EntryName", "value": "Helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR001067", "properties": [{"key": "EntryName", "value": "Nuc_translocat"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "NCBIfam", "id": "TIGR00229", "properties": [{"key": "EntryName", "value": "sensory_box"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23171", "properties": [{"key": "EntryName", "value": "bHLH_HIF1A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14598", "properties": [{"key": "EntryName", "value": "PAS_11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00785", "properties": [{"key": "EntryName", "value": "NCTRNSLOCATR"}]}, {"database": "SMART", "id": "SM00353", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MSARGKPRRRNSEKRKEKSRDAARSRRGKETEVYYELAQQLPLPNGIGTQLDKASIMRLSISHVKLQSLLHSLLDPKLEDEAKLPVVLDRKLDQQYQKALDGFMLIIADEGDMMYVSEKVSKHVGLTQNDLIGHCVYDYTHPCDHEEIQELVQKVPCKTTPVDTCSFFMRFKSTLTTKGRNINLKGATYKVLHCTGRHLLLDLPPRSSGPASMSCLMLVAEPIPHPSYIDIPLGTSTFLTRHNMDMTFTYCDDKMQDLLGYHSKSLIGHSLFDYHHAMDGEVIDKAFKNLYSKGQTVTPLYRFLVSGGGYVWVTTQATVIMHTRTEKPQFIVCVNFIISSVEESQQILSSVQLQQPKDEVVCMEEEEEEE", "length": 370, "molWeight": 42060, "crc64": "5EA842DD824CC2C2", "md5": "31006D1766EEAE99CF3CCACDC27CBE77"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 1, "Compositional bias": 2, "Non-terminal residue": 1}, "uniParcId": "UPI002B30001E"}, "cluster_size": 1, "family": "Melinnidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHY2", "uniProtkbId": "A0AAQ5BHY2_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519692.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519692.1"}], "value": "Serine/threonine kinase 17b"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519692.1"}], "value": "STK17B"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHY2"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHY2"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519692.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519692.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15815621", "citationType": "journal article", "authors": ["Hillier L.W.", "Graves T.A.", "Fulton R.S.", "Fulton L.A.", "Pepin K.H.", "Minx P.", "Wagner-McPherson C.", "Layman D.", "Wylie K.", "Sekhon M.", "Becker M.C.", "Fewell G.A.", "Delehaunty K.D.", "Miner T.L.", "Nash W.E.", "Kremitzki C.", "Oddy L.", "Du H.", "Sun H.", "Bradshaw-Cordum H.", "Ali J.", "Carter J.", "Cordes M.", "Harris A.", "Isak A.", "van Brunt A.", "Nguyen C.", "Du F.", "Courtney L.", "Kalicki J.", "Ozersky P.", "Abbott S.", "Armstrong J.", "Belter E.A.", "Caruso L.", "Cedroni M.", "Cotton M.", "Davidson T.", "Desai A.", "Elliott G.", "Erb T.", "Fronick C.", "Gaige T.", "Haakenson W.", "Haglund K.", "Holmes A.", "Harkins R.", "Kim K.", "Kruchowski S.S.", "Strong C.M.", "Grewal N.", "Goyea E.", "Hou S.", "Levy A.", "Martinka S.", "Mead K.", "McLellan M.D.", "Meyer R.", "Randall-Maher J.", "Tomlinson C.", "Dauphin-Kohlberg S.", "Kozlowicz-Reilly A.", "Shah N.", "Swearengen-Shahid S.", "Snider J.", "Strong J.T.", "Thompson J.", "Yoakum M.", "Leonard S.", "Pearman C.", "Trani L.", "Radionenko M.", "Waligorski J.E.", "Wang C.", "Rock S.M.", "Tin-Wollam A.M.", "Maupin R.", "Latreille P.", "Wendl M.C.", "Yang S.P.", "Pohl C.", "Wallis J.W.", "Spieth J.", "Bieri T.A.", "Berkowicz N.", "Nelson J.O.", "Osborne J.", "Ding L.", "Meyer R.", "Sabo A.", "Shotland Y.", "Sinha P.", "Wohldmann P.E.", "Cook L.L.", "Hickenbotham M.T.", "Eldred J.", "Williams D.", "Jones T.A.", "She X.", "Ciccarelli F.D.", "Izaurralde E.", "Taylor J.", "Schmutz J.", "Myers R.M.", "Cox D.R.", "Huang X.", "McPherson J.D.", "Mardis E.R.", "Clifton S.W.", "Warren W.C.", "Chinwalla A.T.", "Eddy S.R.", "Marra M.A.", "Ovcharenko I.", "Furey T.S.", "Miller W.", "Eichler E.E.", "Bork P.", "Suyama M.", "Torrents D.", "Waterston R.H.", "Wilson R.K."], "citationCrossReferences": [{"database": "PubMed", "id": "15815621"}, {"database": "DOI", "id": "10.1038/nature03466"}], "title": "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.", "publicationDate": "2005", "journal": "Nature", "firstPage": "724", "lastPage": "731", "volume": "434"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519692.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519692.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC114760", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHY2", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714423.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519692.1"}, {"key": "GeneId", "value": "ENSG00000081320.12"}]}, {"database": "HGNC", "id": "HGNC:11396", "properties": [{"key": "GeneName", "value": "STK17B"}]}, {"database": "OpenTargets", "id": "ENSG00000081320", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000154014", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 2"}]}], "sequence": {"value": "MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRVLCLA", "length": 46, "molWeight": 5335, "crc64": "CEEB8C2B8F006FC0", "md5": "654E0CCFB6BCF52851016BB4A3DDF7F3"}, "extraAttributes": {"uniParcId": "UPI0032CC409C"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0V6", "uniProtkbId": "A0AA96S0V6_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50027.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50027.1"}], "value": "Na-Ca exchanger/integrin-beta4-like protein"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 7000, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041716988"}, {"type": "Domain", "location": {"start": {"value": 487, "modifier": "EXACT"}, "end": {"value": 594, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 613, "modifier": "EXACT"}, "end": {"value": 712, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 729, "modifier": "EXACT"}, "end": {"value": 848, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 979, "modifier": "EXACT"}, "end": {"value": 1077, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 1096, "modifier": "EXACT"}, "end": {"value": 1194, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 1212, "modifier": "EXACT"}, "end": {"value": 1311, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 1329, "modifier": "EXACT"}, "end": {"value": 1429, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 1446, "modifier": "EXACT"}, "end": {"value": 1545, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 1560, "modifier": "EXACT"}, "end": {"value": 1658, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 1674, "modifier": "EXACT"}, "end": {"value": 1772, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 1788, "modifier": "EXACT"}, "end": {"value": 1886, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 1902, "modifier": "EXACT"}, "end": {"value": 2001, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 2016, "modifier": "EXACT"}, "end": {"value": 2114, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 2132, "modifier": "EXACT"}, "end": {"value": 2229, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 2244, "modifier": "EXACT"}, "end": {"value": 2342, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 2358, "modifier": "EXACT"}, "end": {"value": 2456, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 2472, "modifier": "EXACT"}, "end": {"value": 2570, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 2586, "modifier": "EXACT"}, "end": {"value": 2683, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 2699, "modifier": "EXACT"}, "end": {"value": 2797, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 2813, "modifier": "EXACT"}, "end": {"value": 2911, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 2927, "modifier": "EXACT"}, "end": {"value": 3024, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 3040, "modifier": "EXACT"}, "end": {"value": 3138, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 3154, "modifier": "EXACT"}, "end": {"value": 3252, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 3268, "modifier": "EXACT"}, "end": {"value": 3367, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 3382, "modifier": "EXACT"}, "end": {"value": 3479, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 3495, "modifier": "EXACT"}, "end": {"value": 3592, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 3608, "modifier": "EXACT"}, "end": {"value": 3705, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 3721, "modifier": "EXACT"}, "end": {"value": 3819, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 3835, "modifier": "EXACT"}, "end": {"value": 3933, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 3949, "modifier": "EXACT"}, "end": {"value": 4048, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 4063, "modifier": "EXACT"}, "end": {"value": 4160, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 4176, "modifier": "EXACT"}, "end": {"value": 4274, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 4290, "modifier": "EXACT"}, "end": {"value": 4388, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 4404, "modifier": "EXACT"}, "end": {"value": 4501, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 4517, "modifier": "EXACT"}, "end": {"value": 4615, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 4631, "modifier": "EXACT"}, "end": {"value": 4730, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 4745, "modifier": "EXACT"}, "end": {"value": 4843, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 4859, "modifier": "EXACT"}, "end": {"value": 4956, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 4972, "modifier": "EXACT"}, "end": {"value": 5070, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 5086, "modifier": "EXACT"}, "end": {"value": 5184, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 5200, "modifier": "EXACT"}, "end": {"value": 5298, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 5314, "modifier": "EXACT"}, "end": {"value": 5413, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 5428, "modifier": "EXACT"}, "end": {"value": 5528, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 5545, "modifier": "EXACT"}, "end": {"value": 5642, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 5660, "modifier": "EXACT"}, "end": {"value": 5763, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 5783, "modifier": "EXACT"}, "end": {"value": 5894, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 5919, "modifier": "EXACT"}, "end": {"value": 6017, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 6035, "modifier": "EXACT"}, "end": {"value": 6132, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 6146, "modifier": "EXACT"}, "end": {"value": 6244, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 6262, "modifier": "EXACT"}, "end": {"value": 6359, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 6373, "modifier": "EXACT"}, "end": {"value": 6473, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 6491, "modifier": "EXACT"}, "end": {"value": 6589, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}, {"type": "Domain", "location": {"start": {"value": 6607, "modifier": "EXACT"}, "end": {"value": 6704, "modifier": "EXACT"}}, "description": "Calx-beta", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00237"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022837"}], "id": "KW-0106", "category": "Ligand", "name": "Calcium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50027.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460104", "properties": [{"key": "ProteinId", "value": "WNS50027.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007154", "properties": [{"key": "GoTerm", "value": "P:cell communication"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0030001", "properties": [{"key": "GoTerm", "value": "P:metal ion transport"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.60.40.2030", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "56"}]}, {"database": "InterPro", "id": "IPR051171", "properties": [{"key": "EntryName", "value": "CaCA"}]}, {"database": "InterPro", "id": "IPR038081", "properties": [{"key": "EntryName", "value": "CalX-like_sf"}]}, {"database": "InterPro", "id": "IPR003644", "properties": [{"key": "EntryName", "value": "Calx_beta"}]}, {"database": "PANTHER", "id": "PTHR11878:SF65", "properties": [{"key": "EntryName", "value": "NA_CA-EXCHANGE PROTEIN, ISOFORM G"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11878", "properties": [{"key": "EntryName", "value": "SODIUM/CALCIUM EXCHANGER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03160", "properties": [{"key": "EntryName", "value": "Calx-beta"}, {"key": "MatchStatus", "value": "32"}]}, {"database": "SMART", "id": "SM00237", "properties": [{"key": "EntryName", "value": "Calx_beta"}, {"key": "MatchStatus", "value": "53"}]}, {"database": "SUPFAM", "id": "SSF141072", "properties": [{"key": "EntryName", "value": "CalX-like"}, {"key": "MatchStatus", "value": "56"}]}], "sequence": {"value": "MNTLAIALVLLTVYVSSSQAQILRFGPRFEIGRYDVTEGQKLGVRLSASILTHSLLTTGPFSSAEGEIEVDICIEDGTEEPLATPGSDYVLCDTVPGGNWTDRFTVQFVLRQANSSTVDICIGDDNIFEDTENFQLRICAVRFSESISGILGTATGFDSVTAPVEIDDNDVVSIHWERNSVTVTEGEDRQIGLRAVAEGVYARPISIGVQCSPVDSTNGRPASRSTDWIVTQTQLTFSSVDQLMSVSDVPLRALIVDDGIAEPQESFLCNLQSGNADPVKAVPPTQITVTIVDNDELIISWEGDFYEFRESETATVTLVTDSNFESDVVVNGFPSRISENRITLSLPGPTFEGFGQFPATINKVEFRGVRYGVARVAGIRQEPDVASTFDDFLFTSTIKTSTENFDIKNDDILEYDELLMAEFSISNLLEEGWLAIKGQFPICYIAIEDDDFVTVNFNQSEYVVNESARQVMVSLEITGQFFKNVSVTIECIDGNATVAVCRYEQDLYRVAEEAGYLEVALVLNLAASFPLSVNASTLFLLDASVGDAASVVDFLGINELIITFPPGVTRVPFNITIIDDNFPENSELFNLDVNLVGGGGDSRFLQIGSPKQPLVEIFDSDVAVNISLDSTTYSIFENEARVIVTLQLSAPYTQDIIVEVSLSENAAGVDFESSGFPRFVTIPAGQTSVSFPVLVIDEGIVEKDEGFIVSFSYTAGQPGVSVTPGFDQGAITIRNDDELRVRFERELYTVSEDAGSVSVKIIASSTASFDYDVNIAISDISAVFGGDYGDMDILGSGSGLVIPEPLPGVNRVNTTILIRAGLNMDRFAVIIIDDEMYESLESFHINLTVSESFQASNILEGDPIVSRVDIQDDDGVSVHFDPAEYEVREGENKVLILLANRTFNVPFDINVNLFDSSAVAPGDYEDRDYVVRFDVDTQMGMLVVHSNEDTILEDPELFLARLTVPSGLDRVVPGEPSEARVTITDRTPAEVFFDPVMYPIDEGEDANLTLRLTREVASGVVILVQFITRDGTAERDEDYLGEVYNVTFEGTNVAVVPVPSIDDDLVEGVEEFTAVIVVPADTQREHLVTRGSPDTAVVEINDNDMLMVFFDRERYQVNEDDRVATITLRSSKPHELPYNITVNGADGTAEFPGDYSERSFDLLFPAGATSVTFDIPIVDNEVFEGPEFFNLSIVIPQASVDIGVEPGMPIRAFVDILDDEVVNVFFDPTSDIVTEGEDAELTVRADRNFTIPFSVIVTLSDDSAVAPGDYNSSQSPYVLTFQPGQSTQTILVPTNDDTTVEMTELFTAALSLPAVNPTPGVVVIQPEEATVTIVDNEEPLVVVLRRNETVPEGQDALVLVEVSSTDYEFNFTVTLSTMDIPDSAKAPADYQPGPYTASFTAGQASAVVRVGTEDDDISELTEHFKVTIDSTSQDRTRVEIGADNTSFVAILDDDNVTCSFSVDSISVTEGESARVTIDISSADFSFPFTVTLSYMDGSAIEGEDYTRGNITVEFAPGQSSVSFDVPTIDDDRVEKLENFKIMKVGSSRPDKVSPASPDMVTIEITDNDERTLIISPQNYTVVEGQIVNITLVLDSDEFDCEFNVTLVNTDMSATAPEDYTSGPYTVTFQPNQTTAVLMIPTKDNSTAELTEVFKVEISSTSIPAQIVIGEPDDSYVTILDNDDVTCSFSVDSMSVTEGESARVTIDISSADFSFPFTVTLSYMDGSAVEGEDYTRGDITVEFAPGQSSASFNVSTIDDDRVEKLENFKIMKVNSSRPDKVSPASPDMVTIEIIDNDERTLSIIPQNYTVVEGQKVNITLVLDSDEFDCEFNVTLVNTDMSATAPEDYTSGPYTVTFQPGQTTAILMIPTEDDSIAELTEVFKVVINSTSIPAQILIGEPDDSYVTILDNDDLTCSFSDDSISVTEGESARVIIETSSADFSFPFTVTLSYMDGSAVEGEDYTSGDVTVEFTPGQSSVSFDVPTIDDDRVEKLENFKIMKVSSSRPDKVSPASPDMVTIEIIDNDERTLSIIPQNYTVVEGQIVNITLVLDSDEFDCEFNVTLVNTDMSATAPEDYTSGPYTVTFQPNQTTAIVMVPTKDDSTSELTEVFKVEISSTSIPAQIVIGEPDDSYVTIEDSDDLTCSFSVDSMSVTEGESARVTIDISSADFSFPFAVTLSYMDGSAVEGEDYTSGDVTVEFTPGQSSVSFDVPTIDDDRVEKLENFKIMKVSSSRPDKVSPASPDMVTIEIIDNDERTLSIIPQNYTVVEGQIVNITLVLDSDEFDCEFNVTLVNTDMSATAPEDYTSGPYTVTFQPNQTTAIVMVPTKDDSTSELTEVFKVEISSTSIPAQIVIGEPDDSYVTIEDNDDLTCSFSVDSMSVTEGESARVTIDISSADFSFPFTVTLSYMDGSAVEGEDYTRGDVTVEFAPGQSSASFDVSTIDDDRVEKLENFKIMKVNSSRPDKVSPTSPDMVTIEITDNDERTLSIIPQNYTVVEGQKVNITLVLDSDEFDCEFNVTLVNTDMSATAPEDYTSGPYTVTFQPNQTTAILMIPTEDDSIAELTEVFKVEISSTSIPDQIVTGEPDDSYVTILDNDVIECSKAPENATVTEGEVASLTIVCSGEYEFDFTLNLDSMDDSAVAPGDYNGGPYSVVFTAGQQSAILSVPTNDDSIAEMDQVFKVMITGSDLPDKVIIVQPDTCYVTIEDDDDVIECSKAPENATVTEGEVASLTIVCIGEYEFDFTLNLDSMDDSAVAPGDYVGGPYSVVFTAGQQSAIFSVPTNDDSVAEMDQVFKVMITGSDQSDKVVIAQPDTCYVTIEDDDDVIECSKAPENATVTEGQVASLTIVCSGEYEFDFTLNLDSMDDSAVSPGDYVGGPYSVVFTAGQQSAILSVPTNDDSIAEMDQVFNVIIAGSDQSDKVIIVQPDTCFVTIKDNDVIECAKAPQNATVTEGEVASLTIVCSGEYEFDFTLNLDSMDDSAVAPGDYVSGPYSVVFNAGQQSAILSVPTNDDSIAEMDQVFKVMITGSDLPDKVIIVQPDRCYVTIQDDNDVIECSKAPENATVTEGEVASLTIVCSGEYEFDFTLNLNNMDDSAVAPADYRPGPYSVFFTAGTEMMQLNVDTLEDSIAELKEEFKVMITGSNKPGKVVIEQPDTCYIWIEDNDKISVSFETISYVVLESNNASITVVTDPTMFSFPFTVIIRTMNITATGNEDYVSGDYTVTFKPNQARATFVVPTIQDTISERNEVYKVTIVSTSQPDQVMIGDPDVANVTILDDEELTCIFSQPMYSVTEGEIARITIDISSADFSFPFTVTLSYMDGSAVEGEDYTRGDVTVEFAPGQNSTSFDVPTIDDDRVEKLESFKIMKVGTSEPLLISPGPQSMTTVQIVDNDVLMVSVVQNYTVAEGETAPIVVEVDSIEFDCEFNVTLLNTDDTAKSPGDYTPGPYVVNFQPGQRTVTLMVPTVDDSIAELTEVFNVMIASTTLPMKVLISERNTSFVEIEDSDVIECSKAPENATVTEGQEASLTIVCSGEYEFDFTLNLDSMDDSAVAPGDYVGGPYSVVFTAGQESAILSVPTNDDSIAEMDQVFKVMITGSDQSDKVIIVQPDTCYVTIEDNDVIECSKAPENATVTEGEVASLTIECSGEYEFDFTLNLDSMDDSAIAPGDYVSGPYSVDFTAGQQSAILSVLTNDDSIAEMDQVFKVMITGSNQPLKVIIAQPDTCYVTIEDDDDVIECSKAPENATVTEGEVASLTIVCSGEYEFDFTLNLDSMDDSAVAPGDYVGGPYTVVFNAGKQSAILPVPTNDDSIAEMDQVFKVMITGSDLPDKVIIAQPDTCYVTIEDDNDVVTCRKAAENITVTEGQLVNVTIECSGEYEFDFTLDVATLNGTAFAPGDYEAGVMNVLFSAGETSRSVSVVTIDDSVIELEEFFKLMISGSDQGNKVVIAEPGMCFVIVRDNDGLSCFFSDDSISVTEGESARVTIETSSADFSFPFTVTLSYMDGSAVEGEDYTRGNITVEFVPGQNSVSFDVPTIEDGRVEKLESFKIMKVGTSEPDKVSQGTPSMITVEIEDDDERTLIISPQNYTVVEGQKVNITLVLDSDEFDCEFNVTLVNTDITTAPEDYTSGPYTVTFQPGQTTAILMIPTEDDSTPELTEVFKVEISSTSIPAQIVIGEPDDSYVTILDNDDVTCSFSVDSMSVTEGESARVTIDISSADFSFPFTVTLSYMDGSAVEGEDYTSGDITVEFVPGQSSVSFDVPTIDDDRVEKLENFKIMKANSSRPDKVSPTSPDTVTIEITDNDERTLSIIPQNYTVVEGQKVNITLVLDSDEFDCEFNVTLVNTDMSATAPEDYTSGPYTVTFQPGQTTAILMIPTEDDSIAELTEVFKVEISSTSIPAQILIGEPDDSYVTILDNDVIECSKAPENATVTEGQVASLTIVCSGEYEFEFTLNLDSMDDSAVAPGDYIGGPYSVVFTAGQQSAILSVPTNDDSIAEMDQVFKVMITGSDLPDKVIIAQPDTCYVTIEDDNDVVTCRKAAENITVTEGQLVNVTVECSGEYEFDFTLDVATMDGTAFAPGDYEAGVMNVLFSAGETSKSVSVVTIDDSVIELEEFFKLMISGSDKGDKVVIAEPRMCFVIIRDNDGLSCFFSDDSISVTEGESARVTIETSSADFSFPFTVTLSYMDGSAVEGEDYTRGDITVEFVPGQNSVSFEVPTIEDGRVEKLESFKIMKVGTSEPDKVSQGTPSMITVEIEDDDERTLIISPQNYTVVEGQKVNITLVLDSDEFDCEFNVTLVNTDMSATAPEDYTSGPYTVTFQPNQTTAILMIPTEDDSTAELTEVFKVEISSTSIPDQIVTGEPDDSYVTIQDNDVIECSKAPENATVTEGQVASLTIVCSGEYEFDFTLNLDSMDDSAVAPGDYNGGPYSVVFTAGQQSAILSVPTNDDSIAEMDQVFKVMITGSDLPDKVIIAQPDTCFVTIEDDDDVIECSKAPENATLTEGEVASLTIECSGEYEFDFTLNLDSMDDSAIAPGDYVSGPYSVDFTAGQQSAILSVLTNDDSIAEMDQVFKVMITGSNQPLKVIIAQPDTCYVTIEDDDDVIECSKAPENATVTEGEVASLTIVCSGEYEFDFTLNLDSMDDSAVAPGDYVGGPYSVVFNAGKQSAILPVPTNDDSIAEMDQVFKVMITGSDLPDKVIIAQPDTCYVTIEDDNDVVTCRKAAENITVTEGQLVNVTIECSGEYEFDFTLDVATMDGSAVAPGDYEAGVMNVLFSPGETSRSVSVVTIDDSVIELEEFFKLMISGSDQGNKVVIAEPRMCFVIVRDNDGLSCFFSDDSISVTEGESARVTIETSSADFSFPFTVTLSYMDGSAVEGEDYTRGNITVEFAPGQSSASFDVPTIDDDRVEKLENFKIMKVGTSESDKVSQGTPSMITVEIQDNDVLVVMFQPDDYQVAEGETATVSLITNLAYSFNFTVNVVCENGTAFSPDDFTDGMFTAEFLASPNEAGRASIQVQTIPDNVFEALEFFKCSLIVPDMDMDNVVSGQPDMARVNITDNTGADCFFNPDVYLINEGSNATIIVETSVTVAKRFSCIVTTEDDSANSPSDYISGTKVAIFEIGSTSAEVVYRTVFDEIREGLESFRARLSVSEPMMAMGVRAVDPELALVDIIDDDELFVMFERNMYMVTEGNPPPEDGLLNVTIIATRQCEDPYTLNIVASDGSATEGEDYRGQSFTVTIPALTTAATFSVPIINDLVFESDETFFLQIEAPQNRDGECRDVKLGSPDRATVLIKNDEPVVTIEIEESDLDVVENENMVEVCLVKSGPSTEPIMAMLIVEEIVSGSGDSNVSAASENDDFSPVPVPDTLTIPPNVTRMCFDVLINDDPMVERTEPFKITVVFPPDQPALQNGELSIASGDNGTITGTINIQDDDNITIEFEFDMYMRNESDALFEVSILASGSASFPYSFEVSFMNIEAVEPFDYVFIPLTRIFEPGQTSTTFSVPIVDDNFDEIDESFKLIITIPESSRQAGVSVGVKSVTTLIIKDNDVPEAVFNPQNYSVPEGSNASITVVLDKIPVKQCTVTVTTVDLSAEGSVDYTPVVRDLIFMPNQSSVTFAVPTILDGEKEQQEFFRVDLTTTDDECVVGTPAQAFVRILDDSVLSVQFEREMYMTFEVDGMVEVRIIASSPSDFAYDIVVSSMDIEAIDPDDYTFPDMTLTFAPGEVDKLLSIPVFPDMLDERNETFKLTITIPEASGSQGVQEGDPITAVVLIKDSDVPEAVFNPQNYSVPEGSAANITVVLDKIPIEQCTVTVTTVDLSAEDTLDYSGVVAEVVFPAGQTSATFSVNTLGDVLLEGDEHFKVVLSAGDGGCSVGSPDEAFVTVQDQQVDVIVRFNPDTYVVTEGQDGNAVISLEADGEHGFDFVVMVRAMDGFAIIDEDYEGDLFSVLFPANVNTASFNLSILDDQFAESPENLTLKLEVPADEAAKGVQLGSPDVALVTILDDDDLVISFVVPSYTVKENVGTVTVEVIASRPANFDYSVTVRTAEDTAMTPEDFEDNTFTVNFPAGSTQQSFDVVITDDNILEEMESLDLQLSISDDLIDIGVQVGSNGRAVINIMDNDLVVRFRRPEVSVPEENERAPVEVLALGDLSMDFSIIVMAINGSAIENLDFIGNMWMVDFPSAVSSQSFFIPIVQDAVVEDTELFTLKIVVSDELSRRLTVASPEIMTVIITDLVNDTVIGDPLFTVPLPSLHIDDDKLKGSALCFEYHGHSGEHYNLISDSCVSVNTLYSAGVNKSKLNVMSEIGIRAEDSAGGCHTISVLREGCSASLNGAPVTGTVSRSGVVITARRSRVRVSLPNCESQKRLTLWVLCNRRNDEDMLEIVVSRGDGLRPTAHGLIGQFWNVPIGIEPYTGVFDGKQLNKDDGVYLVHVAYPGSQNRTFVAEFRPRAWDSKVPCLYAGNSMAGPMAEAPQYRDNVIDGAVNSYNVDNLFTTDYQHSKYKSDCN", "length": 7000, "molWeight": 759804, "crc64": "2D40DC03DDECDA9F", "md5": "A1790B9465B05CFD16D2844AA72A4CF2"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 53}, "uniParcId": "UPI002B2D6C87"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7NK72", "uniProtkbId": "A0AAU7NK72_SCYPA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Scylla paramamosain", "commonName": "Mud crab", "taxonId": 85552, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR32022.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Portunoidea", "Portunidae", "Portuninae", "Scylla"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR32022.1"}], "value": "Adipokinetic hormone/corazonin-related peptide"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 74, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043706010"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-6F2H5HVG8OV3G", "citationType": "submission", "authors": ["Tan W.T.", "Tang Y.W.", "Lu L.", "Liu A.", "Ye H.H."], "title": "Adipokinetic hormone/corazonin-related peptide promotes ovarian development in the mud crab, Scylla paramamosain.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR32022.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP885732", "properties": [{"key": "ProteinId", "value": "XBR32022.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005179", "properties": [{"key": "GoTerm", "value": "F:hormone activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR010475", "properties": [{"key": "EntryName", "value": "AKH/RPCH_hormone"}]}, {"database": "Pfam", "id": "PF06377", "properties": [{"key": "EntryName", "value": "Adipokin_hormo"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MASWMLVALVVSCVLVGSVTPQITFSRSWVPQGKRSSSPGDIPEPLDPCRDARAATLTSLAGHLLVSLLLCNYK", "length": 74, "molWeight": 7912, "crc64": "CB7248E935F038E2", "md5": "151F87F8570C53AE8E32EACFD47A0377"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D31BD4"}, "cluster_size": 1, "family": "Portunidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEH8", "uniProtkbId": "A0AB38ZEH8_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02696.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02696.1"}], "value": "Venom hemolysin-like 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 213, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044246614"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02696.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517446", "properties": [{"key": "ProteinId", "value": "WXI02696.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MQLKLIFLAIALFQVCLAEESNSKDGSTQTETTKKPSWIGWLIKAPGTVVKETSKFVDAATHETANFAKEAGKVATDIGNQSLQGTLGVAAKGTETVGKIGKELIDRGKTLANNLPFFGKLTQGVLDTGNKVIEAAEGATKKVIGGISKFGEAGFEGVHGVISSIADKTDKTVSGIGEVIRENIDKGHAVVDNTLQHYDELTNKYLPRPVENI", "length": 213, "molWeight": 22625, "crc64": "DE10B7AD72769ADD", "md5": "1F29629EFABB6136A9E204694019742C"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BCAEC"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38Z7H0", "uniProtkbId": "A0AB38Z7H0_PAESU", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia suffruticosa", "commonName": "Tree peony", "synonyms": ["Paeonia moutan"], "taxonId": 45171, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20341.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20341.1"}], "value": "Regulation of cellular response to hypoxia"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 41, "modifier": "EXACT"}, "end": {"value": 53, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-67NUCHPS7RPVN", "citationType": "submission", "authors": ["Zhang Y.", "Gai S."], "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20341.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR237926", "properties": [{"key": "ProteinId", "value": "WRI20341.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005739", "properties": [{"key": "GoTerm", "value": "C:mitochondrion"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043565", "properties": [{"key": "GoTerm", "value": "F:sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007005", "properties": [{"key": "GoTerm", "value": "P:mitochondrion organization"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR055304", "properties": [{"key": "EntryName", "value": "CHCHD2/10-like"}]}, {"database": "PANTHER", "id": "PTHR13523", "properties": [{"key": "EntryName", "value": "COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13523:SF3", "properties": [{"key": "EntryName", "value": "COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 2-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51808", "properties": [{"key": "EntryName", "value": "CHCH"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFEGSSDGSAALGSKMLSGLMRGPEDKVCGPTTRNFQVQRPSRRVPRMPRGSRSRTPAWPLRPGETIAGFETKAWPSDPTGAMTQREATGGGEPRPAAAWARLGQAGPGTSDESCTQAGTCRSATSSGTPICSWLSAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGSNAEPASPDITYQEPKGTQLAQQQQPCFYEIKQFLECAQNQGDIKLCEGFNEVLKQCRLANGR", "length": 240, "molWeight": 25086, "crc64": "3D5B852A86F7DFB1", "md5": "A9D4AF3C508CB65F95E3BCC37BEE205E"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI00388BBC10"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1D3", "uniProtkbId": "A0AAU7P1D3_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30744.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30744.1"}], "value": "Apolipoprotein E"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30744.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 80, "modifier": "EXACT"}, "end": {"value": 80, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30744.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30744.1"}], "value": "8", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30744.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892400", "properties": [{"key": "ProteinId", "value": "XBS30744.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "IGIAEEPLTQLAQVGGEAHPQLLGALAEHGLHLAAVLHQAQLLGALAEHGLHLAAVLHQAAAHVLHVRAQPGLRRLQLLG", "length": 80, "molWeight": 8307, "crc64": "4FF100E5450F7015", "md5": "3E7E347383E280FA0272AE6CDEEFBD3D"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D3C787"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VGX5", "uniProtkbId": "A0AAU7VGX5_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67484.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67484.1"}], "value": "RRM domain protein Bruno2"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67484.1"}], "value": "bruno2"}}], "features": [{"type": "Domain", "location": {"start": {"value": 210, "modifier": "EXACT"}, "end": {"value": 288, "modifier": "EXACT"}}, "description": "RRM", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50102"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00176"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67484.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67484.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750689", "properties": [{"key": "ProteinId", "value": "XBW67484.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0003729", "properties": [{"key": "GoTerm", "value": "F:mRNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "3.30.70.330:FF:000016", "properties": [{"key": "EntryName", "value": "CUGBP Elav-like family member 1 isoform 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.70.330", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050502", "properties": [{"key": "EntryName", "value": "Euk_RNA-bind_prot"}]}, {"database": "InterPro", "id": "IPR012677", "properties": [{"key": "EntryName", "value": "Nucleotide-bd_a/b_plait_sf"}]}, {"database": "InterPro", "id": "IPR035979", "properties": [{"key": "EntryName", "value": "RBD_domain_sf"}]}, {"database": "InterPro", "id": "IPR000504", "properties": [{"key": "EntryName", "value": "RRM_dom"}]}, {"database": "PANTHER", "id": "PTHR48025", "properties": [{"key": "EntryName", "value": "OS02G0815200 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48025:SF1", "properties": [{"key": "EntryName", "value": "RRM DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00076", "properties": [{"key": "EntryName", "value": "RRM_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00360", "properties": [{"key": "EntryName", "value": "RRM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54928", "properties": [{"key": "EntryName", "value": "RNA-binding domain, RBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50102", "properties": [{"key": "EntryName", "value": "RRM"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQQLLNAATSGSNNSSIHNSQGDGGNSMQSFQNLQNLAALAALANNPAVNQAGGGGLNSMSSLQNALPNVGNGTGGGSHHVIGNGGMNGSGGFSNGSGGFSNGSGGFSNGGGGFSNGGGGMMGGGGDMLSSLGASAQGYSSLQQFGGQSSLFNLGSFGGNGLSNAMTQQPAGNMGGASGLAGGGVNGNSLNAAGAQNSPAGKQTEGPDGSNLFIYHLPQEYTDHDLLQMFVPFGSVISSKVFIDKQTNLSKCFGFVSFDNSASAENAIQSMNGYQIGTKRLKVQLKRPKSDTTLY", "length": 295, "molWeight": 29302, "crc64": "D4621B3506339CBB", "md5": "1455B9D0B73AB93C0E262A8D688D2523"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1}, "uniParcId": "UPI0035D28A6E"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7J8T9", "uniProtkbId": "A0AAU7J8T9_LOCMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Locusta migratoria", "commonName": "Migratory locust", "taxonId": 7004, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89728.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Polyneoptera", "Orthoptera", "Caelifera", "Acrididea", "Acridomorpha", "Acridoidea", "Acrididae", "Oedipodinae", "Locusta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89728.1"}], "value": "Tudor domain-containing protein Tdr25"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 81, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Region", "location": {"start": {"value": 257, "modifier": "EXACT"}, "end": {"value": 282, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 262, "modifier": "EXACT"}, "end": {"value": 282, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89728.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3S1R4NEJO2BB6", "citationType": "submission", "authors": ["Deng S.", "Wang J.", "Ma E.", "Zhang J.", "Xing S."], "title": "Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89728.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR912227", "properties": [{"key": "ProteinId", "value": "XBN89728.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "2.30.30.140:FF:000018", "properties": [{"key": "EntryName", "value": "Serine/threonine-protein kinase 31"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.50.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR035437", "properties": [{"key": "EntryName", "value": "SNase_OB-fold_sf"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR050621", "properties": [{"key": "EntryName", "value": "Tudor_domain_containing"}]}, {"database": "PANTHER", "id": "PTHR22948:SF29", "properties": [{"key": "EntryName", "value": "FI02030P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22948", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50304", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "AVEKLQYVTERMEDAANFSVFPDVKKGELCAALFKDDGLWYRAKILSCDSNEISVQFIDYGNTSTTDEVRVLPTDLLEMPGIAEHCSLSLPEEVNNWPENACSEFLRLVSGGETEFHMKLVKEGPLKVVSLEYNGEPVELMLKQSHSKENLQKASTLINETSSTVEESTNGIPLSDKTLLQNTGLQQVNPSSDKVKIEDKLPQEGQRLELLESEQKDGNQMKIKHSEMLIQDLSVEVKVQSLPDQTKKDIIVSEKVCEPSAADTSKSEASFDENNTTPDLLR", "length": 282, "molWeight": 31451, "crc64": "FC3A4B366983758A", "md5": "3597E76C612C98EFBFC5FB3E590D40EE"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D2DA4C"}, "cluster_size": 1, "family": "Acrididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7J8Y3", "uniProtkbId": "A0AAU7J8Y3_LOCMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Locusta migratoria", "commonName": "Migratory locust", "taxonId": 7004, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89722.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Polyneoptera", "Orthoptera", "Caelifera", "Acrididea", "Acridomorpha", "Acridoidea", "Acrididae", "Oedipodinae", "Locusta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89722.1"}], "value": "Tudor domain-containing protein Tdr19"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 53, "modifier": "EXACT"}, "end": {"value": 158, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00567"}]}, {"type": "Domain", "location": {"start": {"value": 274, "modifier": "EXACT"}, "end": {"value": 343, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00567"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3S1R4NEJO2BB6", "citationType": "submission", "authors": ["Deng S.", "Wang J.", "Ma E.", "Zhang J.", "Xing S."], "title": "Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89722.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR912221", "properties": [{"key": "ProteinId", "value": "XBN89722.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR050621", "properties": [{"key": "EntryName", "value": "Tudor_domain_containing"}]}, {"database": "PANTHER", "id": "PTHR22948:SF29", "properties": [{"key": "EntryName", "value": "FI02030P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22948", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MAPELKKIIDITRQHDAKLAEEELLEESRRVPQLDPPRAGQWPLLLLRPGREGHVWVRLITPACDAAFRQLMSGLEEWYGQRALGLPVAVDALRPGQVVAAPVRGFWCRARLLRVGRGRAALASIDEATTACLPLAQLRLLEPRFAQLPQQAFRCRLQEAGGGGVPRWLLQRLSARRLPALFLAGGWPAPPTARLQLPAAHAAHQLSRCRPRLPPEGATVLARVSHVSRGGAVFVRMRGDCVPALEAALRRAVAMATAEQVARASPLRLLADPSRVLLAPAAGGLWCRAAVHKYAPYSAQVVVRLIDHGMKKVFPVNDLIILDRVDELINNLPPQALRVHLAGVRTPLSEAEASLLRRVTSRRTVALQAVGTAGGRRGRRVRLFARRGPTQTSLCSLALLVRGQRDRAGEPL", "length": 412, "molWeight": 45059, "crc64": "A619B0D4135EBEEF", "md5": "F3535E2AA33BE9FAF2D295503C954C1E"}, "extraAttributes": {"countByFeatureType": {"Domain": 2}, "uniParcId": "UPI0035D297ED"}, "cluster_size": 1, "family": "Acrididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N6H5", "uniProtkbId": "A0AAN0N6H5_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34062.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34062.1"}], "value": "Glutamate receptor ionotropic kainate-3 like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034100"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 540, "modifier": "EXACT"}, "end": {"value": 559, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 911, "modifier": "EXACT"}, "end": {"value": 937, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1255, "modifier": "EXACT"}, "end": {"value": 1279, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 340, "modifier": "EXACT"}}, "description": "Receptor ligand binding region", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01094"}]}, {"type": "Domain", "location": {"start": {"value": 879, "modifier": "EXACT"}, "end": {"value": 938, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00060"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34062.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34062.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154988", "properties": [{"key": "ProteinId", "value": "WRW34062.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKNPINSSGIFETNSPEIEKSFIHLIKKANISSSNFKIDYEIRHITSLENSYQANKAACDLIQSGVWAFYSSKSNQLSWILDSYADYFNIPYFNINSLSAFKNKNFTFNLNIDQNFLTDAISSILTKKTQFIFFYQNFEDLIFYKDLLKNNYDLKFVLINQDEIIPNVLEQSKIAGETQFIIALSLKKTEKFLFQALKMGMITEYHRYYLINLDASLLNLSLFENLNKNFTWFNLQKIIYTEQKTLDYYLMKDAVNLYLDAIRQLVKESTKIYPPKTNKTLCSSLFKNSIEDLSTKYKWKSGERLLNKLKQIKFFGQTGIIKFNSSNKRDSLDLEIKRLTKKKIEKIGDWNNLVGVKIFNFDTNLTLEVSKKVFKIGVLDLEPFAFLDERTPAQWPLKHRLKGIYIDLIELLHKEIKFKDYELYLINREEYFSNFYNFLNEKYFRKYRNQDINFGLMEENFDFVIGELIDSNQIYPKKLPAQPFFTLSIVALFIEETLCDSFDNIKSLKNSNFYSNFDNYFCSNHFALYQPIFKVFDFDLWLSLVVCYIFVSFLVYFIINFGQNNTNNLIDSLSKCEKKNNQFKKTLNKLNKKSKNSKKIIKENQIKENTKEQNKIYEYYDENIAISNINNQKQLIICDEDLSLVELNMNNLNNQSDESIILDENQLIDNLSKNQLNILQISQLEPSFKQKTIIESIPTQNIILNQDINILNENEIIQSSFNNLNNTRILNRNFNSTIDSSLFQIQNNSQFIPLYFNKNKTDENILENSSTNNFSIVGFELVDEQLNKNYQDTIYQNNIYQENENISFINKNLNDSEKLNFLNSFVVQNTSKNIENSIPEKLIKFPLTKQENLSKTNQANISLLNLKNNSIEYKLNENYNLKPINLSTCFWYTFAVACHQKTLFKRSSFSICFISSIWRFFTIIIFCIFTANLTAYLNKIAFLSTHSFPLIPASLKPEIQFVCSWPTCNLIQSSKNQFMQQINDKIYKINSDQGKKVFLERLIQGNTIYLTNEFEANYLKSKFCNLTIMKLNEKFLGLDLIKYNSLNDKNDQFELQLENKEKNIKSTFKSLNKIDFKKSYFHKLIDLLMNKKVNEDKKPNKFKNKVYNFDSNSLIQNFGLTFQFQSPYHQVFEQKIITLKEKNLIASLLYKWKKLTSPCNSKENFNSWFSFNSHNLDDQYLHNNRPIPVDGNIEKFKNSENNLKANHFRTNLKFDQSYCATEDKSNSWINSLLNKFFKITNCSFSDEKNPWLKRIIFLLALGLSISCLMVLIEIFISIVTNKDKNLKKNNQTMLANNNLSTFPQNSCLNTDVKNENNKNVDDSISTINKFENSIVSTNNSSNIPSLIIHQNCQVDKNLLNTNFENTMNMSVTNDYNQKNPNRPQHFTFISEPLDEISIETNDGHVLSYQLNDSHQKYINFNLEHQKKASLKAIVYSNQLESSI", "length": 1443, "molWeight": 169293, "crc64": "695CE8E0B5F07D49", "md5": "0DEEEE26B375D1EF3ED210AE51D25EDA"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 3, "Domain": 2}, "uniParcId": "UPI00324F0E75"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI20", "uniProtkbId": "A0AA96MI20_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50041.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50041.1"}], "value": "IgGFc-binding protein-like protein 2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 669, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041702304"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50041.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460118", "properties": [{"key": "ProteinId", "value": "WNS50041.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSTKRELYLLLCTLVTAVLCNSEQYLSNVYGVSVLNRLQAAISSKGCVGGICVCSELNREWSGVFSTGVSLPSVLAKDAATADETQDIQRAIRHVNRIADSMPIANRILDTCKWTRTLFSEKYSSLLEKMNQQTTEDSKVEAVKAAICELNEAVPDPEPAGDVTEVPLFLLYLRYKQEYFGAKDELARKILKEREARTDDDFRKWYQDNLEILRCDVDSAYQKWEIFGNKRKVEDLLVDNDIVADSSLITNSLGLFTAVRDLQPTTDNVAEGTMPVTLTPSGWEAILDGSHTGSPDQLSFEIGEMQVRVAELEGLKSNKASDSKPLESTLNSTLKNVTSLSLEITNARTLCRNGRVQQCNKVASLQKQLTSTSDNFIRDYVSYKSTDSVDGVKKQIQDLQVEIGKAEVQRRSQTALSTTQALDIPEGVQQVSVMFNWTEDSSNLNATFKSLNMTDPLQKRPFLYIQSPPDEGCTGCYDSFQDDVVAERISAKLYFLTMERSWFDPTVLQKAYMKKIIGELSEPYSPSATSQSMLFDDLARRDYLLPFYPTSMVMATDIVVTLKTTSSEAVGAIYKAAWSSSPVKLGIGPFSVVSALEGTYNSQYRYSIENINNEQSEGGSASRLKVRLAGGQIIGMRYQMMESVNVEPAGVTLGPLNITVTPPPGRHRQ", "length": 669, "molWeight": 74291, "crc64": "F197035F0B8BDAB4", "md5": "CDF8DC7F49024A1917494C5B7496C5EF"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B286854"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7J942", "uniProtkbId": "A0AAU7J942_LOCMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Locusta migratoria", "commonName": "Migratory locust", "taxonId": 7004, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89714.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Polyneoptera", "Orthoptera", "Caelifera", "Acrididea", "Acridomorpha", "Acridoidea", "Acrididae", "Oedipodinae", "Locusta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89714.1"}], "value": "Tudor domain-containing protein Tdr10"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 217, "modifier": "EXACT"}, "end": {"value": 275, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Region", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 165, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 144, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89714.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 345, "modifier": "EXACT"}, "end": {"value": 345, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89714.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3S1R4NEJO2BB6", "citationType": "submission", "authors": ["Deng S.", "Wang J.", "Ma E.", "Zhang J.", "Xing S."], "title": "Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89714.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR912212", "properties": [{"key": "ProteinId", "value": "XBN89714.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043186", "properties": [{"key": "GoTerm", "value": "C:P granule"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030719", "properties": [{"key": "GoTerm", "value": "P:P granule organization"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0034587", "properties": [{"key": "GoTerm", "value": "P:piRNA processing"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007283", "properties": [{"key": "GoTerm", "value": "P:spermatogenesis"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.50.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR035437", "properties": [{"key": "EntryName", "value": "SNase_OB-fold_sf"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR050621", "properties": [{"key": "EntryName", "value": "Tudor_domain_containing"}]}, {"database": "PANTHER", "id": "PTHR22948", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22948:SF15", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN-CONTAINING PROTEIN 6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50304", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "STTDELRVLPSDLLQMAGIAEHCSLIPPEEINEWPEDTCSEFLSLVSGGETEFQMKLVKEGLLNVVSLDHNGTPVEVLLKQSYSKESDIEEKVSTAMEELSDIAQKSEERKIDVNTPEISDGEFNHACKEIDTTTSSNNTCNDSQVNDTPKVNESPEVDKREDRETQLQVSAGGDSVFVSHCDSPKDFWIQRKTAAEKLHYVTERMEIAPNFSAFLDAKEGDLCGALFKDDGMWYRARVLSRDNDEISVQFIDYGNTSTTDEVRVLPTDLLEMPGIAEHCSLTIPEEINKWSENNCSEFLRLVGGGETEFQMKLVKDAPLKVISLHYNGEPVELMLKQSYLKESG", "length": 345, "molWeight": 38640, "crc64": "06DCBDCB20FB26EA", "md5": "A4B7DA938F9C81F3F3ED1E0CAAE517A4"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D37BDE"}, "cluster_size": 1, "family": "Acrididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0Z3C7", "uniProtkbId": "A0AAF0Z3C7_HIRNI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hirudo nipponia", "commonName": "Korean blood-sucking leech", "taxonId": 42736, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49278.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Hirudinea", "Hirudinida", "Hirudiniformes", "Hirudinidae", "Hirudo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF05649"}], "value": "Peptidase M13 N-terminal domain-containing protein"}}, "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 4, "modifier": "EXACT"}, "end": {"value": 135, "modifier": "EXACT"}}, "description": "Peptidase M13 N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF05649"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 173, "modifier": "EXACT"}, "end": {"value": 173, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49278.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-ANPA6HQVADV17", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49278.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR759984", "properties": [{"key": "ProteinId", "value": "WPD49278.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004222", "properties": [{"key": "GoTerm", "value": "F:metalloendopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.1380.10", "properties": [{"key": "EntryName", "value": "Neutral endopeptidase , domain2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000718", "properties": [{"key": "EntryName", "value": "Peptidase_M13"}]}, {"database": "InterPro", "id": "IPR042089", "properties": [{"key": "EntryName", "value": "Peptidase_M13_dom_2"}]}, {"database": "InterPro", "id": "IPR008753", "properties": [{"key": "EntryName", "value": "Peptidase_M13_N"}]}, {"database": "Pfam", "id": "PF05649", "properties": [{"key": "EntryName", "value": "Peptidase_M13_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55486", "properties": [{"key": "EntryName", "value": "Metalloproteases ('zincins'), catalytic domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51885", "properties": [{"key": "EntryName", "value": "NEPRILYSIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGLPYFTDLQETLGGYDAKIIAKYILLRGTLLLYHTLPKRFQEMLPSYGFARRLYIILEHDESVCEQETRQNLQYIEEQFYMDISFSGQTKVMADELYKGIKTNLDKQFSSDHCIDDNVKVEIFKKMKGIKVHLGRFELQFFQYKKTSFYNGSYFENFLAFKREFNPTIDPGV", "length": 173, "molWeight": 20471, "crc64": "EDDFE0612963F488", "md5": "097EBF43D2E3AEDCF62CF45648D1E808"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI002B297D42"}, "cluster_size": 1, "family": "Hirudinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LKH6", "uniProtkbId": "A0AAU7LKH6_GIRTI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Girardia tigrina", "commonName": "Planarian", "synonyms": ["Dugesia tigrina"], "taxonId": 6162, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP46542.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Platyhelminthes", "Rhabditophora", "Seriata", "Tricladida", "Continenticola", "Geoplanoidea", "Dugesiidae", "Girardia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP46542.1"}], "value": "5-hydroxytryptamine receptor"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP46542.1"}], "value": "5-HT"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 27, "modifier": "EXACT"}, "end": {"value": 49, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 116, "modifier": "EXACT"}, "end": {"value": 140, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 257, "modifier": "EXACT"}, "end": {"value": 277, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 297, "modifier": "EXACT"}, "end": {"value": 317, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 314, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 328, "modifier": "EXACT"}, "end": {"value": 328, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP46542.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP46542.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DH85PVIN8V0D8", "citationType": "submission", "authors": ["Kreshchenko N.", "Ermakov A."], "title": "Morphometric characteristics of serotonergic nervous system, functional activity and the pathway in Girardia tigrina (Turbellaria, Platyhelminthes).", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP46542.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP886657", "properties": [{"key": "ProteinId", "value": "XBP46542.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd15331", "properties": [{"key": "EntryName", "value": "7tmA_5-HT1A_invertebrates"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24248", "properties": [{"key": "EntryName", "value": "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVAILAMPLSILNEVGKRWWLGVELCDLWICFDVMCCTASILHLVAIAIDRLLTFINVNYVQTRTAARVYLMIIIIWFCSVVISIPARFYHGRDSKDNHIKFSILGKCVINSNHGYTIFSTVGAFYLPMLFMIIIYIRIYKVAQTHIRKKAIRQFNHTNRQHFNIRYIRTHKNRAVMDYKKRLVANSPLSINDSLITTEMSDSLSSHSVIIQSPEKTFSEKETNSVSTKMDTLPMTKDSQMISNLKERIEHKRERKAARTLAIITGCFLLCWLPFFINALLAPFCKDHIKVPEYIESLFLWLGYINSLLNPIIYTIFSPDFRHAFTKL", "length": 328, "molWeight": 38067, "crc64": "2C6B9D638A7FD1F4", "md5": "8A935DB19EDC91FCAA2F4ECDEC5A01A4"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 5, "Domain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D35956"}, "cluster_size": 1, "family": "Dugesiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAJ6N658", "uniProtkbId": "A0AAJ6N658_METSE", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Metridium senile", "commonName": "Brown sea anemone", "synonyms": ["Frilled sea anemone"], "taxonId": 6116, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8BVC"}], "lineage": ["Eukaryota", "Metazoa", "Cnidaria", "Anthozoa", "Hexacorallia", "Actiniaria", "Nynantheae", "Metridiidae", "Metridium"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8BVC"}], "value": "Ms13-1"}}]}, "features": [{"type": "Disulfide bond", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 41, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8BVC"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 3, "modifier": "EXACT"}, "end": {"value": 39, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8BVC"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 5, "modifier": "EXACT"}, "end": {"value": 39, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8BVC"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 5, "modifier": "EXACT"}, "end": {"value": 15, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8BVC"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 13, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8BVC"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8BVC"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DJTSJMA0MPQK7", "citationType": "submission", "authors": ["Mineev K.S."], "title": "Solution structure of Metridium senile toxin Ms13-1 with the unique fold.", "publicationDate": "DEC-2022", "submissionDatabase": "PDB data bank"}, "referencePositions": ["STRUCTURE BY NMR", "DISULFIDE BONDS"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8BVC"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8BVC", "properties": [{"key": "Method", "value": "NMR"}, {"key": "Resolution", "value": "-"}, {"key": "Chains", "value": "A=1-42"}]}, {"database": "SMR", "id": "A0AAJ6N658", "properties": [{"key": "Description", "value": "-"}]}], "sequence": {"value": "CTCECHSPSDGVCECTYDPDGKPPITKTFRLHKDQPCTCTCG", "length": 42, "molWeight": 4578, "crc64": "80D81B80AFC5095F", "md5": "F6F82103DAF71E0855A693FC1CFEF136"}, "extraAttributes": {"countByFeatureType": {"Disulfide bond": 5}, "uniParcId": "UPI002AC9F225"}, "cluster_size": 1, "family": "Metridiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6NDF1", "uniProtkbId": "A0AAU6NDF1_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59760.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59760.1"}], "value": "CSP12"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59760.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59760.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420120", "properties": [{"key": "ProteinId", "value": "WWA59760.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.2080.10", "properties": [{"key": "EntryName", "value": "Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005055", "properties": [{"key": "EntryName", "value": "A10/PebIII"}]}, {"database": "InterPro", "id": "IPR036682", "properties": [{"key": "EntryName", "value": "OS_D_A10/PebIII_sf"}]}, {"database": "PANTHER", "id": "PTHR11257", "properties": [{"key": "EntryName", "value": "CHEMOSENSORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11257:SF13", "properties": [{"key": "EntryName", "value": "GEO07322P1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03392", "properties": [{"key": "EntryName", "value": "OS-D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF100910", "properties": [{"key": "EntryName", "value": "Chemosensory protein Csp2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "NQFRLCSSPSDVTPVWSEDPLFSKDVCGSLLSVPHSTSELIVFPFIIVAKQMALFYPVLSFTEKLPEALETRCAKCTDKQKQMGKALAQEVKKNHPDIWNQLVAMYDPQGKYQQAWQDFLKE", "length": 122, "molWeight": 13925, "crc64": "FC68A956E449AA07", "md5": "DE47D8BC1EA5D31AFD35455D22804B7D"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D330DA"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7N2C7", "uniProtkbId": "A0AAU7N2C7_MARVT", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maruca vitrata", "commonName": "Bean pod borer moth", "taxonId": 497515, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57440.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Maruca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57440.1"}], "value": "Cytochrome p450"}}], "flag": "Fragment"}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 132, "modifier": "EXACT"}, "end": {"value": 132, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57440.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 183, "modifier": "EXACT"}, "end": {"value": 183, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57440.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1RJQRG3KQ0PQG", "citationType": "submission", "authors": ["Esmaeily M.", "kim Y."], "title": "C18 oxylipin, EpOME, mediates the immune resolution at late infection stage in the legume pod borer, Maruca vitrata.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57440.1"}], "value": "23", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBQ57440.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP893332", "properties": [{"key": "ProteinId", "value": "XBQ57440.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005743", "properties": [{"key": "GoTerm", "value": "C:mitochondrial inner membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006700", "properties": [{"key": "GoTerm", "value": "P:C21-steroid hormone biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071375", "properties": [{"key": "GoTerm", "value": "P:cellular response to peptide hormone stimulus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008203", "properties": [{"key": "GoTerm", "value": "P:cholesterol metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0034650", "properties": [{"key": "GoTerm", "value": "P:cortisol metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006704", "properties": [{"key": "GoTerm", "value": "P:glucocorticoid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050479", "properties": [{"key": "EntryName", "value": "CYP11_CYP27_families"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "PANTHER", "id": "PTHR24279", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24279:SF125", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 24 SUBFAMILY A MEMBER 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "ITSSMSFLLYHLAKYQRTQKLLYEEIGKMLVDLKDVGSLKERTPYLQACIKENLRLVPPIPVLTRILPKNIILDRYNIPRGTLIIMSTQDAALKESNFEDATMFKPERWLKPDAKDYHSFASIPFGYGSRKCLGQNIAETMMTLLTTRLIQKYKLEYHYGDIEQTKTFIAKPNKALKIRFIDR", "length": 183, "molWeight": 21307, "crc64": "FD249200B4D46FCA", "md5": "7222A23F07E735C93C4959AF89710FBD"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D29CDF"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LP54", "uniProtkbId": "A0AAN0LP54_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65904.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362059"}], "value": "UDP-glucuronosyltransferase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362059"}], "value": "2.4.1.17"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65904.1"}], "value": "UGT"}}], "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:21032"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:58052"}, {"database": "ChEBI", "id": "CHEBI:58223"}, {"database": "ChEBI", "id": "CHEBI:132367"}, {"database": "ChEBI", "id": "CHEBI:132368"}], "ecNumber": "2.4.1.17", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362059"}]}}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362059"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362059"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009995"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003718"}], "value": "Belongs to the UDP-glycosyltransferase family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003718"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003718"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65904.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145357", "properties": [{"key": "ProteinId", "value": "WRV65904.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050271", "properties": [{"key": "EntryName", "value": "UDP-glycosyltransferase"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "InterPro", "id": "IPR035595", "properties": [{"key": "EntryName", "value": "UDP_glycos_trans_CS"}]}, {"database": "PANTHER", "id": "PTHR48043", "properties": [{"key": "EntryName", "value": "EG:EG0003.4 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48043:SF145", "properties": [{"key": "EntryName", "value": "FI06409P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00201", "properties": [{"key": "EntryName", "value": "UDPGT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00375", "properties": [{"key": "EntryName", "value": "UDPGT"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVKIVFVPLLDYGHLQICFSLGKYLLYKNPENKVYFVCDDENVVKIKSKCLKFECLVFENKITDDQRKKKKLTDRFKLSHQEQFKGGLGKEFMIKMWMERKDVITKLIDEVKPDFVFNENLFNVPYLMNKNYKWGMIVSTNPLKIADQVNYPPMGSGETDPEKFKVYSNILKEFGQEFYDTMNNWYRENNLERKPTLSPIQGSDILNVFMYPKELNYFTPDKIPGKWFQLNCTLVDKKVEDFIVNNNWTKKISLGKNVLTKEFLEKPGKLILFSLGTLVTNSGEFLLEIINKISVLPHKFIINKGKNLQDLILPNNCIGAEFFEQLELLTTVDAFISHGGNNSFTESLYYKVPMIILPVFGDQFDNGRRLEEFKLGRKLDTVNFTTEELALAIEEVTTSSTIKENLNKISESMRKKDDLDELADLIIKICNEC", "length": 433, "molWeight": 50344, "crc64": "16FFF4AA04C0FA33", "md5": "E8B0048C3A968814FF83103EE10949DF"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "uniParcId": "UPI00324EDA4F"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8HP30", "uniProtkbId": "A0AAU8HP30_PINYU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pinus yunnanensis", "commonName": "Yunnan pine", "taxonId": 88732, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI12818.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Pinopsida", "Pinidae", "Conifers I", "Pinales", "Pinaceae", "Pinus", "Pinus subgen. Pinus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI12818.1"}], "value": "Two-component response regulator ARR1"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 167, "modifier": "EXACT"}}, "description": "Response regulatory", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50110"}]}, {"type": "Domain", "location": {"start": {"value": 217, "modifier": "EXACT"}, "end": {"value": 271, "modifier": "EXACT"}}, "description": "HTH myb-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51294"}]}, {"type": "Region", "location": {"start": {"value": 280, "modifier": "EXACT"}, "end": {"value": 324, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 437, "modifier": "EXACT"}, "end": {"value": 459, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 309, "modifier": "EXACT"}, "end": {"value": 318, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 437, "modifier": "EXACT"}, "end": {"value": 454, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Modified residue", "location": {"start": {"value": 103, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "4-aspartylphosphate", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00169"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022553"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00169"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023012"}], "id": "KW-0902", "category": "Biological process", "name": "Two-component regulatory system"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C4D42S7MORCR8", "citationType": "submission", "authors": ["Xu J."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI12818.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP978603", "properties": [{"key": "ProteinId", "value": "XCI12818.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0009736", "properties": [{"key": "GoTerm", "value": "P:cytokinin-activated signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000160", "properties": [{"key": "GoTerm", "value": "P:phosphorelay signal transduction system"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd17584", "properties": [{"key": "EntryName", "value": "REC_typeB_ARR-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.10.60:FF:000007", "properties": [{"key": "EntryName", "value": "Two-component response regulator"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.10.60", "properties": [{"key": "EntryName", "value": "Homeodomain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR045279", "properties": [{"key": "EntryName", "value": "ARR-like"}]}, {"database": "InterPro", "id": "IPR011006", "properties": [{"key": "EntryName", "value": "CheY-like_superfamily"}]}, {"database": "InterPro", "id": "IPR009057", "properties": [{"key": "EntryName", "value": "Homeodomain-like_sf"}]}, {"database": "InterPro", "id": "IPR017930", "properties": [{"key": "EntryName", "value": "Myb_dom"}]}, {"database": "InterPro", "id": "IPR006447", "properties": [{"key": "EntryName", "value": "Myb_dom_plants"}]}, {"database": "InterPro", "id": "IPR001005", "properties": [{"key": "EntryName", "value": "SANT/Myb"}]}, {"database": "InterPro", "id": "IPR001789", "properties": [{"key": "EntryName", "value": "Sig_transdc_resp-reg_receiver"}]}, {"database": "NCBIfam", "id": "TIGR01557", "properties": [{"key": "EntryName", "value": "myb_SHAQKYF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43874", "properties": [{"key": "EntryName", "value": "TWO-COMPONENT RESPONSE REGULATOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43874:SF67", "properties": [{"key": "EntryName", "value": "TWO-COMPONENT RESPONSE REGULATOR ARR2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00249", "properties": [{"key": "EntryName", "value": "Myb_DNA-binding"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00072", "properties": [{"key": "EntryName", "value": "Response_reg"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00448", "properties": [{"key": "EntryName", "value": "REC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52172", "properties": [{"key": "EntryName", "value": "CheY-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF46689", "properties": [{"key": "EntryName", "value": "Homeodomain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51294", "properties": [{"key": "EntryName", "value": "HTH_MYB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50110", "properties": [{"key": "EntryName", "value": "RESPONSE_REGULATORY"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSPLVDRDPQVAKGEAFPVGRSCSDSCCHVGGPTKAAAVTSDEEKFSPSGLHVLVVDDDTFCLAVLERMLRQCEYNVTVCTRVSQAISLVKENREGFDIVMSDVYLPGEDGFKLLEVVGIGLGLPVIMMSANGETNVVMRSIRGGACDYLIKPIRTEELRTIWQHVVRRHRQQCHRHDGKDNHGDFSDHGRVLGDFKKRKHSSCQDITDLNSLKTARVHWTAQLHQRFVKAVNQTGLDNAAPKRILEIMNVPGLTRENVASHLQKYRLYLKRLSGSIPEPRPVASFQAARDGKFGGTMQIRKRGKPTPSSSSSSSSSSAIKTSPLSLELSRNLDHATLKSLEQFQAYERKLVANRVQMLRGAATAAAPSSYMRTNVHVDQGYENGGELRIITHAGRLRRNLQGGGGHRACPADESAAQSFKVDFANLAETKPLTKSFGLSTHQPQFQNPAPTTETPEENDVYKEEAKRLIDETQTIDQEELLFSNFVEENFPHMKIPSDHDQMPTLIASAGDLSEEYFMLGEGFLPRLGDKEEITQVHIP", "length": 540, "molWeight": 59914, "crc64": "EC4FD3B7E3788A09", "md5": "EB23E6F8243603E93E643DE628ACBD50"}, "extraAttributes": {"countByFeatureType": {"Domain": 2, "Region": 2, "Compositional bias": 2, "Modified residue": 1}, "uniParcId": "UPI0035D27AA3"}, "cluster_size": 1, "family": "Pinaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8BC24", "uniProtkbId": "A0AAU8BC24_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Conopomorpha sinensis", "commonName": "litch fruit borer", "taxonId": 940481, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD10481.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Tineoidea", "Gracillariidae", "Conopomorpha"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD10481.1"}], "value": "Opsin"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 314, "modifier": "EXACT"}, "end": {"value": 370, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}, {"type": "Region", "location": {"start": {"value": 156, "modifier": "EXACT"}, "end": {"value": 305, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 394, "modifier": "EXACT"}, "end": {"value": 414, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 156, "modifier": "EXACT"}, "end": {"value": 169, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 170, "modifier": "EXACT"}, "end": {"value": 190, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 255, "modifier": "EXACT"}, "end": {"value": 264, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 272, "modifier": "EXACT"}, "end": {"value": 281, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 289, "modifier": "EXACT"}, "end": {"value": 305, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023305"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023305"}], "id": "KW-0844", "category": "Biological process", "name": "Vision"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5PCR16OJ21JA0", "citationType": "submission", "authors": ["Chang H."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCD10481.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP937554", "properties": [{"key": "ProteinId", "value": "XCD10481.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0007602", "properties": [{"key": "GoTerm", "value": "P:phototransduction"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007601", "properties": [{"key": "GoTerm", "value": "P:visual perception"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050125", "properties": [{"key": "EntryName", "value": "GPCR_opsins"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR001391", "properties": [{"key": "EntryName", "value": "Opsin_lateye"}]}, {"database": "InterPro", "id": "IPR027430", "properties": [{"key": "EntryName", "value": "Retinal_BS"}]}, {"database": "PANTHER", "id": "PTHR24240", "properties": [{"key": "EntryName", "value": "OPSIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00578", "properties": [{"key": "EntryName", "value": "OPSINLTRLEYE"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50096", "properties": [{"key": "EntryName", "value": "IQ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00238", "properties": [{"key": "EntryName", "value": "OPSIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLPAPTKADTAPVEQKLPQMVTEAALLHPLWEDLAAHYGSVAVARGAAKPLGPSFRGHQARKEGRHSGRARSIWCTRAVRRMWCAQCGVPRIAGRTTEVVTVRSARTDDQTKSKREVVCKRCLRRTLPYACDDKATQAEQRSILLPSTAVRDCLLKRHRRKRARSKVSKQTKSNSCSARVTSAQKQQAKGKSSLLAAIPKVSARSARGKQQERSSASESITREPVALPSTPAPPKSDVRATATMPSRIQPLEAMPTTTTVVPSRSNDDNNAPKKAAAPLLNIPSISRKPNKDKSGKSGSGEVKKEVANTSAECKLAKVALMTISLWFMAWTPYLVINYTGVFEGAPLSPIATIWGSLFAKANAVYNPIVYGISHPKYQAALYARFPSLACQGTPDDSGSVASATTAASEEKPAA", "length": 414, "molWeight": 44635, "crc64": "F3D144791320A441", "md5": "9F9E18601709FFBE0191DAFE059FCE1B"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 2, "Compositional bias": 5}, "uniParcId": "UPI0035D37487"}, "cluster_size": 1, "family": "Gracillariidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTJ7", "uniProtkbId": "A0AAT9UTJ7_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41671.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41671.1"}], "value": "Cytochrome P450 3637A3"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003690"}], "value": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides"}], "commentType": "FUNCTION"}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 476, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043792988"}, {"type": "Binding site", "location": {"start": {"value": 421, "modifier": "EXACT"}, "end": {"value": 421, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41671.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117231", "properties": [{"key": "ProteinId", "value": "WIM41671.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016712", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008395", "properties": [{"key": "GoTerm", "value": "F:steroid hydroxylase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006082", "properties": [{"key": "GoTerm", "value": "P:organic acid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006805", "properties": [{"key": "GoTerm", "value": "P:xenobiotic metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000238", "properties": [{"key": "EntryName", "value": "Cytochrome P450 2A6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050182", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_fam2"}]}, {"database": "PANTHER", "id": "PTHR24300:SF376", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 15A1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24300", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 508A4-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MISSAMIFFLLIFVIFLLSLIAAKRPKKYPPGPIFLPIIGSIYAVPGQAAHFNIERWRQKHGNIIGHRYGPSYEIYVTGVDESLAALKHPNFQGRKIFYHRNSGIKRGLFFNDGDKWSVIKRFTLNYFSEFQKIKIKDVMVDEMNQLFSNIVPNTVVEMNYQFFPIALNVLMKLLSSITSTRDSTMNFILTHTYKSLHETRPTGIENYFPIIRKLFFAKDNSVQVVHNYLKKSINEHRATLKVDQPRDYIDAFLIEQEKRRALGDSDTFTDEELVVDCYDLIRAGSISTADAIALVMLYLVLYPDAQNKMIQEINANIGRDIMPTLDDKKKLPYCEAVIAESLRINPIVPFTAPHRATEETEFYGYVIPKNTIVKVSLWTLFRDPQLWKDPDDFRPERFIVDGEFVKYPYHLPFGLGKRSCLMEVMARNIIFLYIASFFQKFSIHLPHGEPYPSTDLVQGSVAGPQPFKVLIKSLR", "length": 476, "molWeight": 54934, "crc64": "ED046F86BE5B1065", "md5": "B1AB7F797415C03AA3078FDC5C8DE081"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Binding site": 1}, "uniParcId": "UPI0035D395A4"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7BBU7", "uniProtkbId": "A0AAU7BBU7_9NEOB", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Dyscophus guineti", "commonName": "Sambava tomato frog", "taxonId": 111069, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44907.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Microhyloidea", "Microhylidae", "Dyscophinae", "Dyscophus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "value": "Galectin"}}}, "features": [{"type": "Domain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 145, "modifier": "EXACT"}}, "description": "Galectin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51304"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022734"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "id": "KW-0430", "category": "Ligand", "name": "Lectin"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9LKRFH5MKF7BD", "citationType": "submission", "authors": ["Zaman S.", "Roelants K."], "title": "Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.", "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44907.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR480787", "properties": [{"key": "ProteinId", "value": "XBE44907.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005829", "properties": [{"key": "GoTerm", "value": "C:cytosol"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030246", "properties": [{"key": "GoTerm", "value": "F:carbohydrate binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0016936", "properties": [{"key": "GoTerm", "value": "F:galactoside binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:2000562", "properties": [{"key": "GoTerm", "value": "P:negative regulation of CD4-positive, alpha-beta T cell proliferation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0032689", "properties": [{"key": "GoTerm", "value": "P:negative regulation of type II interferon production"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0010628", "properties": [{"key": "GoTerm", "value": "P:positive regulation of gene expression"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00070", "properties": [{"key": "EntryName", "value": "GLECT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.60.120.200:FF:000124", "properties": [{"key": "EntryName", "value": "Galectin-4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.200", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR013320", "properties": [{"key": "EntryName", "value": "ConA-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR044156", "properties": [{"key": "EntryName", "value": "Galectin-like"}]}, {"database": "InterPro", "id": "IPR001079", "properties": [{"key": "EntryName", "value": "Galectin_CRD"}]}, {"database": "PANTHER", "id": "PTHR11346", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11346:SF188", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00337", "properties": [{"key": "EntryName", "value": "Gal-bind_lectin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00908", "properties": [{"key": "EntryName", "value": "Gal-bind_lectin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00276", "properties": [{"key": "EntryName", "value": "GLECT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49899", "properties": [{"key": "EntryName", "value": "Concanavalin A-like lectins/glucanases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51304", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTCRAGYQMSCDASVPFRTCLATHLSHNRSIIVHGSVPSGATRFHINLMNSGTKDVYLHFNPRFKEGVVVRNCKHGGTWSIEERDLPCMPFGAGQCFQLEIKNEGNAFGIYSNGKKICSFSRHNQDDAIDTLEIEGDVCLSCVEY", "length": 145, "molWeight": 16137, "crc64": "764D63B2A16F8A3D", "md5": "53381A697CB323BCFA42D989A193F35F"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D33A39"}, "cluster_size": 1, "family": "Microhylidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZE77", "uniProtkbId": "A0AB38ZE77_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71722.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71722.1"}], "value": "Venom CUB domain protein 1"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 249, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044347522"}, {"type": "Domain", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 120, "modifier": "EXACT"}}, "description": "CUB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00431"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 249, "modifier": "EXACT"}, "end": {"value": 249, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71722.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71722.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510797", "properties": [{"key": "ProteinId", "value": "WXH71722.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.60.120.290", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000859", "properties": [{"key": "EntryName", "value": "CUB_dom"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "InterPro", "id": "IPR052129", "properties": [{"key": "EntryName", "value": "Spermadhesin-Link_domain"}]}, {"database": "PANTHER", "id": "PTHR46908:SF8", "properties": [{"key": "EntryName", "value": "C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46908", "properties": [{"key": "EntryName", "value": "CUBILIN-LIKE PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00431", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MATSRRLNILIVSINLILLGTAINGQKDIVQITVGEEDIVLTSPGYPDYVRSGADIKWKLNTNNPLAKIQLLCGDLRLIRTNPCEDFVSIDDGNSERKLCGGQSGLTVTSKETTLDIYLHIGPHTNGILHCNARLILPIIPTEVTLKLRDAAYLLLTPKKMAKYLEKRWIFRTEPGIRLSVTCPDFRFANSNPCSQGMEVDNGETSKIYCGSQGGLIIFSHGQEIKLKIFTGFYGGGIAKCMIQAINGP", "length": 249, "molWeight": 27366, "crc64": "2D994AE3DA4C8825", "md5": "E0A72D4C59D2B7F343AB44B947BCBE6C"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388C0717"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BGU6", "uniProtkbId": "A0AAQ5BGU6_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519055.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519055.1"}], "value": "Transmembrane protein 127"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519055.1"}], "value": "TMEM127"}}], "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 11, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BGU6"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BGU6"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519055.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519055.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15815621", "citationType": "journal article", "authors": ["Hillier L.W.", "Graves T.A.", "Fulton R.S.", "Fulton L.A.", "Pepin K.H.", "Minx P.", "Wagner-McPherson C.", "Layman D.", "Wylie K.", "Sekhon M.", "Becker M.C.", "Fewell G.A.", "Delehaunty K.D.", "Miner T.L.", "Nash W.E.", "Kremitzki C.", "Oddy L.", "Du H.", "Sun H.", "Bradshaw-Cordum H.", "Ali J.", "Carter J.", "Cordes M.", "Harris A.", "Isak A.", "van Brunt A.", "Nguyen C.", "Du F.", "Courtney L.", "Kalicki J.", "Ozersky P.", "Abbott S.", "Armstrong J.", "Belter E.A.", "Caruso L.", "Cedroni M.", "Cotton M.", "Davidson T.", "Desai A.", "Elliott G.", "Erb T.", "Fronick C.", "Gaige T.", "Haakenson W.", "Haglund K.", "Holmes A.", "Harkins R.", "Kim K.", "Kruchowski S.S.", "Strong C.M.", "Grewal N.", "Goyea E.", "Hou S.", "Levy A.", "Martinka S.", "Mead K.", "McLellan M.D.", "Meyer R.", "Randall-Maher J.", "Tomlinson C.", "Dauphin-Kohlberg S.", "Kozlowicz-Reilly A.", "Shah N.", "Swearengen-Shahid S.", "Snider J.", "Strong J.T.", "Thompson J.", "Yoakum M.", "Leonard S.", "Pearman C.", "Trani L.", "Radionenko M.", "Waligorski J.E.", "Wang C.", "Rock S.M.", "Tin-Wollam A.M.", "Maupin R.", "Latreille P.", "Wendl M.C.", "Yang S.P.", "Pohl C.", "Wallis J.W.", "Spieth J.", "Bieri T.A.", "Berkowicz N.", "Nelson J.O.", "Osborne J.", "Ding L.", "Meyer R.", "Sabo A.", "Shotland Y.", "Sinha P.", "Wohldmann P.E.", "Cook L.L.", "Hickenbotham M.T.", "Eldred J.", "Williams D.", "Jones T.A.", "She X.", "Ciccarelli F.D.", "Izaurralde E.", "Taylor J.", "Schmutz J.", "Myers R.M.", "Cox D.R.", "Huang X.", "McPherson J.D.", "Mardis E.R.", "Clifton S.W.", "Warren W.C.", "Chinwalla A.T.", "Eddy S.R.", "Marra M.A.", "Ovcharenko I.", "Furey T.S.", "Miller W.", "Eichler E.E.", "Bork P.", "Suyama M.", "Torrents D.", "Waterston R.H.", "Wilson R.K."], "citationCrossReferences": [{"database": "PubMed", "id": "15815621"}, {"database": "DOI", "id": "10.1038/nature03466"}], "title": "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.", "publicationDate": "2005", "journal": "Nature", "firstPage": "724", "lastPage": "731", "volume": "434"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519055.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519055.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC012307", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AC021188", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000713754.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519055.1"}, {"key": "GeneId", "value": "ENSG00000135956.11"}]}, {"database": "HGNC", "id": "HGNC:26038", "properties": [{"key": "GeneName", "value": "TMEM127"}]}, {"database": "OpenTargets", "id": "ENSG00000135956", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000005154", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 2"}]}, {"database": "GO", "id": "GO:0008285", "properties": [{"key": "GoTerm", "value": "P:negative regulation of cell population proliferation"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0032007", "properties": [{"key": "GoTerm", "value": "P:negative regulation of TOR signaling"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR033331", "properties": [{"key": "EntryName", "value": "TMEM127"}]}, {"database": "PANTHER", "id": "PTHR28358", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN 127"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR28358:SF1", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN 127"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYAPGGAGLPGGRRRRSPGGSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDSAAPAGHRRLLFPGHPV", "length": 99, "molWeight": 10194, "crc64": "6F6220B295DABC7C", "md5": "99F0027EF820F6A4C93CBF81344DB824"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0032C6D8BB"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBP8", "uniProtkbId": "A0AAU6PBP8_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20544.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20544.1"}], "value": "Venom peptide"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 51, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043896245"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20544.1"}], "value": "U_LCTX_4_Cm12", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20544.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480813", "properties": [{"key": "ProteinId", "value": "WXB20544.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MNFKLLRWVILFVIYCGTCQLSNVLPEGTVLDKNGKPLKPVILPKKEIVLE", "length": 51, "molWeight": 5812, "crc64": "8D6B1AA747C50DF8", "md5": "8D4895D8621B75D6BAD6807B9954BDFC"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D360A5"}, "cluster_size": 2, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBV1", "uniProtkbId": "A0AAU6PBV1_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Osedax japonicus", "taxonId": 385425, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42270.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Sedentaria", "Canalipalpata", "Sabellida", "Siboglinidae", "Osedax"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012543"}], "value": "chitin synthase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012543"}], "value": "2.4.1.16"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42270.1"}], "value": "CS1"}}], "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:16637"}, {"database": "Rhea", "id": "RHEA-COMP:9593"}, {"database": "Rhea", "id": "RHEA-COMP:9595"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:17029"}, {"database": "ChEBI", "id": "CHEBI:57705"}, {"database": "ChEBI", "id": "CHEBI:58223"}], "ecNumber": "2.4.1.16", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00048014"}]}}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00046329"}], "value": "Belongs to the chitin synthase family. Class IV subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 77, "modifier": "EXACT"}, "end": {"value": 101, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 132, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 165, "modifier": "EXACT"}, "end": {"value": 189, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 263, "modifier": "EXACT"}, "end": {"value": 285, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 344, "modifier": "EXACT"}, "end": {"value": 362, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 391, "modifier": "EXACT"}, "end": {"value": 410, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 438, "modifier": "EXACT"}, "end": {"value": 456, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 463, "modifier": "EXACT"}, "end": {"value": 482, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 512, "modifier": "EXACT"}, "end": {"value": 534, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 546, "modifier": "EXACT"}, "end": {"value": 563, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 990, "modifier": "EXACT"}, "end": {"value": 1012, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1024, "modifier": "EXACT"}, "end": {"value": 1046, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1052, "modifier": "EXACT"}, "end": {"value": 1074, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1086, "modifier": "EXACT"}, "end": {"value": 1102, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1114, "modifier": "EXACT"}, "end": {"value": 1133, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1319, "modifier": "EXACT"}, "end": {"value": 1338, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1367, "modifier": "EXACT"}, "end": {"value": 1388, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 214, "modifier": "EXACT"}}, "description": "Chitin synthase chs-1/2 N-terminal putative transporter", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF23000"}]}, {"type": "Region", "location": {"start": {"value": 585, "modifier": "EXACT"}, "end": {"value": 608, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1443, "modifier": "EXACT"}, "end": {"value": 1538, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1554, "modifier": "EXACT"}, "end": {"value": 1579, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 586, "modifier": "EXACT"}, "end": {"value": 605, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1453, "modifier": "EXACT"}, "end": {"value": 1463, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1477, "modifier": "EXACT"}, "end": {"value": 1492, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1494, "modifier": "EXACT"}, "end": {"value": 1506, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1527, "modifier": "EXACT"}, "end": {"value": 1537, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38831357", "citationType": "journal article", "authors": ["Tilic E.", "Miyamoto N.", "Herranz M.", "Worsaae K."], "citationCrossReferences": [{"database": "PubMed", "id": "38831357"}], "title": "Hooked on zombie worms? Genetic blueprints of bristle formation in Osedax japonicus (Annelida).", "publicationDate": "2024", "journal": "Evodevo", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42270.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-2J69OR40U6SUT", "citationType": "submission", "authors": ["Tilic E."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXA42270.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP475509", "properties": [{"key": "ProteinId", "value": "WXA42270.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004100", "properties": [{"key": "GoTerm", "value": "F:chitin synthase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006031", "properties": [{"key": "GoTerm", "value": "P:chitin biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd04190", "properties": [{"key": "EntryName", "value": "Chitin_synth_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.90.550.10:FF:000139", "properties": [{"key": "EntryName", "value": "Chitin synthase 8"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR004835", "properties": [{"key": "EntryName", "value": "Chitin_synth"}]}, {"database": "InterPro", "id": "IPR055120", "properties": [{"key": "EntryName", "value": "Chs-1/2_IV_N"}]}, {"database": "InterPro", "id": "IPR029044", "properties": [{"key": "EntryName", "value": "Nucleotide-diphossugar_trans"}]}, {"database": "PANTHER", "id": "PTHR22914", "properties": [{"key": "EntryName", "value": "CHITIN SYNTHASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22914:SF42", "properties": [{"key": "EntryName", "value": "CHITIN SYNTHASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03142", "properties": [{"key": "EntryName", "value": "Chitin_synth_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23000", "properties": [{"key": "EntryName", "value": "ChitinSynthase_IV_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53448", "properties": [{"key": "EntryName", "value": "Nucleotide-diphospho-sugar transferases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLNQAVTPSHISSGSTLVYDDKKMAAESPQVEEEEEETSDLDDDVINSEQWNIFRVIPRERISASESLQGFLRIIKVFIYLILFAILLGSLVMSKISIVMITTSYGMIRDKLDTLNRVDDVYDELQKKRNTVITIIMLCMAIPNALTFIMYFFKMAFGSQPWPKPMALVQILVMESFHTVGICILVFVLMPRLDMIRAVCLMNAVCLIPAVCKVCFGHPPNFGPGTQKEQTYMHLQSEMTPEQMEKKQTIMDNLNKTNKMKKMLWYGANIAALIVQITGIVMIFFGSYDTRNLGDTFNSLTGVIDSETRQVNITTTTSIPPKPFSNIIYRNVEWSGAAVDGSRWMFPICLILVSMMWWENFIEKNVSFANGQYKIPLRDVKAQMHVLRQKAMVIASFWSIGIIVAFPYVFLQDFKIEFYIADKRQKVFADYLSEYTPVIVQVVSGVAGYITAVLTCKLCMQMVSFNIPLVLSTPVTVIILFLQCKNQMITNSEFEWLCPEGFGQTSSSGGTIFHIICAILWWFSEMVISGHIWWPRQNTMDKMEKLFVAPLYSSILLEQSFLFNRRRRDAEVKYNNRGIVDFILEDPDREKNEEDEESNKAERGENTLQQDDEIVVPTIYGCATMWHETKNEMTQLLKSVFRMDKDQCARRNLREQDPTFQDPDYYEFETHVLFDDATELNDDEEFVPNQFVRQFIEVIDEAGSSVHKAAISLECPERTPTPYGGRLTWKLPGGTLIIMHLKDKNKIRHKKRWSQCMYMYYLLGYRLCGISNDDLWKGTNSKDQRQKTQFAPGSIFKYLPEEIARKAANTFMLALDGDVDFKPDAVRLLVDLLKKNKKVGAACGRIHPIGAGPVVWYQDFEYAISHWLQKAAEHIYGCVLCSPGCFSLFRGSALMDDNVMRRYTVKASAPVEHVQFDQGEDRWLCTLLLQQGYRVEYSAAADALTYAPESFHEFYNQRRRWGPSTMMNSLDLLSTWQITIRRNDNISTPFMAYQFLLFVSGILGPATVLLMIGGSFNSVLGTNLWQSHMIALCPTAFYILVCFTTKCDTQVLVAQIMSALYAIVMMVVIVGLVINAFMQSITSPNIIFLIMLGGFYATAAVLHPQEFGCVIPGLLYFLLIPSGYLLLQLYSICNIHVVSWGTREVATKKTKEEIEMERIEEEEKKRKEKLKKKGLIAWLGLDSIANDLKEFYITMIGRGKAEKEENDLVSGLKEEIENLKNELDGKRPRNELQEILARKEAAKQAEVVPVKKKIKRDELTNPRWIEEDILGSGEIKYLDDKEITFWKQLIKAHLHPLDKDKRKEAQDAQNLIDLRNNLVFGYLMLNFLWIILLFQLQLLKETLEDDFYVPIPRLDDPQGEPDKFEPLGLIFLVMFAVILVVQFTATIAHRWVTFLHIIARTSILQTEDTLAGKLRLVEKLQSIGDIIEDDQFGIPDKSRGSGIYESLESVSNRTRRNGVRRRSNSAGESERSNSRDRPHRKKHRPRRHRKRGLGNQQVGGNTLSRNFQRRYDYLRNQVQQDEGYARSRSRSKARHRKVDMSDVYKTVRGYNYGAGGGGGGGKQHRRARIPTNDAYSSRM", "length": 1579, "molWeight": 181098, "crc64": "C9AA1EA63823F161", "md5": "FA9748054409931E69C3EE12F38B2C90"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 17, "Domain": 1, "Region": 3, "Compositional bias": 5}, "uniParcId": "UPI0035D394D6"}, "cluster_size": 1, "family": "Siboglinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTJ2", "uniProtkbId": "A0AAT9UTJ2_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41666.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41666.1"}], "value": "Cytochrome P450 3634C2"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 396, "modifier": "EXACT"}, "end": {"value": 416, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 456, "modifier": "EXACT"}, "end": {"value": 473, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 455, "modifier": "EXACT"}, "end": {"value": 455, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41666.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117226", "properties": [{"key": "ProteinId", "value": "WIM41666.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSLLNIFTIIYTSSLVAPLMVLLLGFVIKYIYTRCRRDPRMVELANTLPGPRGFPLIGNGLDFHLREDALQLVLEYKEKYGDVYRLWIGNTLAIFFSNITDVENVFMNSKILGKPQLFKPFRDFFGDGLFTTYSIPKWRRNRRHFQSLFIPGAVGIYVAEINEKVYHAVDKMKELVDGPEFDVWESMGHLSFDVMNKTLMNAEVNERDVATMQYHTSITIAQTICFKMLCLPWLQHEILKWFFYKNKIQRLRRNIVSFVRKLIEKKECEIKQQIEAHKNKTVEDIPPKRLITLAYELTEQGKDDSIMIDELITMLAGGTGSPGILGSFFLLAVAIHQDIQNRLYDELYEVFGDGDRMADEDDIARFPYLDKVLKETLRRFPILPLMFREVEDDTKIGNRLIPAGTMVVVSVGAIHFNPEYYPDPWKFNPENFNAEAVEKRPKLAFLAFSAGPRNCIGIHFAMLQMKLTLIALLRNYSIYTKMKMDDIYMNNGFPTVSVNGFKLTLKQRIRKPTYLLCNE", "length": 519, "molWeight": 60195, "crc64": "EF5CDDF4C5800446", "md5": "B70C8AF86403E742B88F8B1E89AC251C"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 3, "Binding site": 1}, "uniParcId": "UPI0035D3991D"}, "cluster_size": 8, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0PB87", "uniProtkbId": "A0AAF0PB87_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Bottapotamon lingchuanense", "taxonId": 2562587, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Bottapotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}], "value": "G-protein coupled receptor"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}], "value": "scaffold1802736"}}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 64, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 98, "modifier": "EXACT"}, "end": {"value": 118, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 146, "modifier": "EXACT"}, "end": {"value": 146, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}], "value": "CJTD03", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}], "value": "CJTD03", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69298.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR517351", "properties": [{"key": "ProteinId", "value": "WMS69298.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR053093", "properties": [{"key": "EntryName", "value": "GPCR-like"}]}, {"database": "PANTHER", "id": "PTHR47760", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47760:SF1", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "RVPREAGDCQAPSFTPPDNQTWWVACLIHDTSNKGYFIVYVWIRQALVTFLPIIAVVCLNMLTLRGFMRHTRMRRDMLNRRVSGQPSVIFNSREEKNLMGLLIAAISSFVITIVPSGIANAINSSTNTSELTFVIFSAVANNLEIL", "length": 146, "molWeight": 16372, "crc64": "4009D99F5A49A827", "md5": "BEB939A66872F4A39AA48A00C04A55C9"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 2}, "uniParcId": "UPI002B2EC062"}, "cluster_size": 1, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96SJC3", "uniProtkbId": "A0AA96SJC3_PAELC", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia lactiflora", "commonName": "Chinese peony", "synonyms": ["Paeonia albiflora"], "taxonId": 35924, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94113.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03190"}], "value": "Spermatogenesis-associated protein 20-like TRX domain-containing protein"}}}, "features": [{"type": "Domain", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 114, "modifier": "EXACT"}}, "description": "Spermatogenesis-associated protein 20-like TRX", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03190"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-816JBB05UD0I7", "citationType": "submission", "authors": ["Shi Y.J."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94113.1"}], "value": "S-CPA A", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94113.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR552626", "properties": [{"key": "ProteinId", "value": "WNT94113.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0009507", "properties": [{"key": "GoTerm", "value": "C:chloroplast"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "3.40.30.10", "properties": [{"key": "EntryName", "value": "Glutaredoxin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR024705", "properties": [{"key": "EntryName", "value": "Ssp411"}]}, {"database": "InterPro", "id": "IPR004879", "properties": [{"key": "EntryName", "value": "Ssp411-like_TRX"}]}, {"database": "InterPro", "id": "IPR036249", "properties": [{"key": "EntryName", "value": "Thioredoxin-like_sf"}]}, {"database": "PANTHER", "id": "PTHR42899", "properties": [{"key": "EntryName", "value": "SPERMATOGENESIS-ASSOCIATED PROTEIN 20"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR42899:SF1", "properties": [{"key": "EntryName", "value": "SPERMATOGENESIS-ASSOCIATED PROTEIN 20"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03190", "properties": [{"key": "EntryName", "value": "Thioredox_DsbH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52833", "properties": [{"key": "EntryName", "value": "Thioredoxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPVKNTGGSHSFYLSRFERGRKGPSERGRKRIQSSVNWHSWGEEAIQEAKHQKKPIFLSIGSSSSYWCHVMDVKTFNHKVVAKLLNDSFVCIKVDRDEHPHIAKEYISYMQIQESTHMRYRDCWYLDGYKIRFDEEKSKSRKIRPESDNKQIRYHFDILDDMPLNVFLSFDLEPFNASFYYPLGSLLFTLSYYNQPWWKPLREKSHSYFDDFFNELPKTATSPHLRHHFSRNTLYLCAEKYVHIAHVQQQYIVDDCHQKFIM", "length": 262, "molWeight": 31408, "crc64": "F7D1D87740BA9E24", "md5": "256E4EEABC068AD8BB939032AE75533C"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI002B2ED4EC"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QKC4", "uniProtkbId": "A0AAU0QKC4_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56485.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56485.1"}], "value": "Odorant receptor"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 80, "modifier": "EXACT"}, "end": {"value": 98, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 131, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56485.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56485.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56485.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970378", "properties": [{"key": "ProteinId", "value": "WPO56485.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MSKKKPTHLQKHYLKILCRLIYYIGICDCWYEDSDRSRTHKIIYKIWIFFMNSFLILNTINEILACTRSDLTVRERNDLIQFSFGHISVCAKYMFLMLQKDRIKVLFKRLVDGSRSTFTSSEVEKKSVKKAIAYSVGLALATYGTLALSVVDAYLRSRKAGIISC", "length": 165, "molWeight": 19140, "crc64": "5C00923A0D070747", "md5": "6240A4A6A13C878671F0BBF8D9D47127"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 3}, "uniParcId": "UPI003091F7E4"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6ND58", "uniProtkbId": "A0AAU6ND58_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59771.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59771.1"}], "value": "OR4-like protein"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 78, "modifier": "EXACT"}, "end": {"value": 97, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 109, "modifier": "EXACT"}, "end": {"value": 131, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59771.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 132, "modifier": "EXACT"}, "end": {"value": 132, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59771.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59771.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420131", "properties": [{"key": "ProteinId", "value": "WWA59771.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VGYLLLAMAKSYKIVYHRSVYENLVSELRSMWPRGEVSEEEHQILSTALKHLNYVIQGYYWCNNALLVIFLSPPFMEIIKILMGYEVPLILPFFYWFPFDPFQRGYYEVILGAQTWHGLITIWFMLCGDLLF", "length": 132, "molWeight": 15669, "crc64": "1B422BF41B3BBB6C", "md5": "E6BAF1162955009CC8095C970B3A2770"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 2}, "uniParcId": "UPI0035D33C57"}, "cluster_size": 3, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0MVK8", "uniProtkbId": "A0AAU0MVK8_UREUN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Urechis unicinctus", "commonName": "Fat innkeeper worm", "synonyms": ["Chinese penis fish"], "taxonId": 6432, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59946.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Echiura", "Xenopneusta", "Urechidae", "Urechis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59946.1"}], "value": "Heat shock protein family A member 12 variant X7"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59946.1"}], "value": "HSPA12"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007381"}], "value": "Belongs to the heat shock protein 70 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59946.1"}], "id": "KW-0346", "category": "Biological process", "name": "Stress response"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FQL9M4QGPVUS3", "citationType": "submission", "authors": ["Liu D.D."], "publicationDate": "FEB-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59946.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OM803167", "properties": [{"key": "ProteinId", "value": "WOS59946.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0140662", "properties": [{"key": "GoTerm", "value": "F:ATP-dependent protein folding chaperone"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd10229", "properties": [{"key": "EntryName", "value": "ASKHA_NBD_HSP70_HSPA12"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR043129", "properties": [{"key": "EntryName", "value": "ATPase_NBD"}]}, {"database": "InterPro", "id": "IPR013126", "properties": [{"key": "EntryName", "value": "Hsp_70_fam"}]}, {"database": "PANTHER", "id": "PTHR14187", "properties": [{"key": "EntryName", "value": "ALPHA KINASE/ELONGATION FACTOR 2 KINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14187:SF5", "properties": [{"key": "EntryName", "value": "HEAT SHOCK 70 KDA PROTEIN 12A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00012", "properties": [{"key": "EntryName", "value": "HSP70"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53067", "properties": [{"key": "EntryName", "value": "Actin-like ATPase domain"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MQHLSSVMADGSMKELSDSFHKQNKEHVLVAAIDFGTTYSGYAFSFTVNKDDIRMFSKWGNVLGVPMSFKTPTVVLTKNAGNEFVDFGYGALHAYSNLEEDELEDYSIYEKFKMYLHKTKNLGSKTYITAKKGLNASALSIFSHGLRYLSDHLLETIKDQTGSKPGKDLIRWVITVPAIWSDGSKQFMRQAALKAGIIDTMDSQSLVIALEPEAASLYCRQLDVHHLLSTNKDESKMPVGTKYLVLDCGGGTLDVTVHHLRDFNKVAELYQATGSDLGGSKVDDNFIELLKNVLGADVVDAYQNESPADWLNMMSSFEQKKRVVDPRKSEKTNISISAELGTIYMEVKGENIKKAISPEWKSKGMSVANGVLRIPHETMLGVFAPIVSAVVDHVKDLMKIPQVRDTTHILVVGGFGESPVLQSALRDEFEGTMKIIVPADASHCVMKGATLFGHNPSAIVSRRSRKTYGTDVYPIFDPTKHDPGKTKMYGDKRRAEGLFRTWIKQGEEVQMGKALTFSHVPVTPDQTNMSIGLFCSELNDPRYCSDTGVDQLGNITVQLPGSGLDRRVEVKIMFGGTEITVEGRDCRPGGSSAKTTVNFLSD", "length": 602, "molWeight": 66456, "crc64": "9CECBA746205EC13", "md5": "2DBB83D1EC4239DE83A15786B2AA68E6"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0035D3B485"}, "cluster_size": 2, "family": "Urechidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N5X3", "uniProtkbId": "A0AAN0N5X3_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34061.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34061.1"}], "value": "Glutamate receptor ionotropic kainate 2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034100"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 560, "modifier": "EXACT"}, "end": {"value": 578, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 636, "modifier": "EXACT"}, "end": {"value": 659, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 820, "modifier": "EXACT"}, "end": {"value": 841, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 430, "modifier": "EXACT"}, "end": {"value": 795, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00079"}]}, {"type": "Domain", "location": {"start": {"value": 440, "modifier": "EXACT"}, "end": {"value": 504, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor L-glutamate and glycine-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00918"}]}, {"type": "Binding site", "location": {"start": {"value": 515, "modifier": "EXACT"}, "end": {"value": 515, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 520, "modifier": "EXACT"}, "end": {"value": 520, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 686, "modifier": "EXACT"}, "end": {"value": 686, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 687, "modifier": "EXACT"}, "end": {"value": 687, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 731, "modifier": "EXACT"}, "end": {"value": 731, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Site", "location": {"start": {"value": 692, "modifier": "EXACT"}, "end": {"value": 692, "modifier": "EXACT"}}, "description": "Interaction with the cone snail toxin Con-ikot-ikot", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 83, "modifier": "EXACT"}, "end": {"value": 347, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 743, "modifier": "EXACT"}, "end": {"value": 801, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34061.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34061.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154987", "properties": [{"key": "ProteinId", "value": "WRW34061.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0038023", "properties": [{"key": "GoTerm", "value": "F:signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006801", "properties": [{"key": "GoTerm", "value": "P:superoxide metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "1.10.287.70:FF:000105", "properties": [{"key": "EntryName", "value": "Eye-enriched kainate receptor, isoform A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000178", "properties": [{"key": "EntryName", "value": "Glutamate receptor subunit"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.200", "properties": [{"key": "EntryName", "value": "Superoxide dismutase, copper/zinc binding domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR001508", "properties": [{"key": "EntryName", "value": "Iono_Glu_rcpt_met"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "InterPro", "id": "IPR036423", "properties": [{"key": "EntryName", "value": "SOD-like_Cu/Zn_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00177", "properties": [{"key": "EntryName", "value": "NMDARECEPTOR"}]}, {"database": "SMART", "id": "SM00918", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49329", "properties": [{"key": "EntryName", "value": "Cu,Zn superoxide dismutase-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIIRSQYFILSIYLCLISIIKCDVIKIGALFSENDIEERIALELAVNRVNQINTSRILKNIELQPIIKTIQNTDILDVKDKVCDLLKMGVAAIFGPLQSRQATLVQIIADKFEIPHILLRNDFIFTRKKISINMYPNAFTLTKAVIDLVKNLQWQDFAVVYENNEDAIYANEFLKAAREEVRYSDLKDGKLKVRPRNWNVKILQFKPNSEYADTFWQLRKYGLNNFVIVVKNENLYRIMKWAQQTGMVTYKFSFIIASLDMHSINLEEFSYARSNIYYFKVTNELNRELVKTHYWQCTLKNCPNLPYDNNYLSTTSALIYDGILVLAQALREAKANSKIIQVQSLECNRDLSWSYGTTFINLMRSVQTRGITGHIEFDTTTYRSKVELNLMRLEQTGLVKIGQWSENHFIKEKELKLQQPSSGPLLSGQTLRVITVFNKPYLMLKNSSKELVGNDRFEGYVVDLINELSKVLNFRYEFIILPSKKYGTCTASSGCDGMLGNITRGEVDIAVVDLTITAERQGAVDFTLPFMNTGIGVLYYKVTKEKISLFSFMNPFSPSVWYFLVLLTIFSALALHVMGRLSPYEWFNPYPCKQDENILENPYNFRNTVWYINGALLQQGSEFAPRSSSTRWTAGVWYFVTLILVSSYTANLAAFLTVVNYEYPFNEAVELLQHPEIKFGCKENGSTCHFFRDSNNTNYKAMWELMQFVDSNDAGRDRVEKDAGTFAYFMESKAIEYDTERYCSVTQRGGLLDNKGYGIAVNQNNKTLKRQLDEGILQLQEGGVLHILYDRWWKQKGGGTCLDSGTGDATELNLENVGGVFVVLIIGMFVSVFTSFFELFYKTYKTPSFAQSSFKENIAHELKFAFDIQVPKKINPKSNDSFRNHSIHIKCNSNNYVAGQGSSNYRSIAKENFDSNSESNIEKKLSNKPYNNIAYTNNSHISRSYLPTSLLSKNNQQYRPDSKPNYVTPKANYVSTSTNEPNVDSNLLLSSNSPNLNYEYKCEYKKQPKLPQMSDSQKDYSIVGLIHKSSYQGYVLFTSLSSSGYEGHENLSVKVHITSSRTHGQPVKEAFSWRIYNQHSIDLNGQCALFLTSDDLLHDLTINFGPLIVGKQHTFGSEEFTNLILHNQSIGKQRKQGLSSLLGKTLMLIGAESGIKICTTLLPAGSKHVYEAKFHYPIAGRVKIVHANNQLQASLLTEYLMYSNGERKESKHKWQIVEALTNNDYNYEKVYADKYNYEKNNCANLKYNHILPLEEINELNNLIVNTEMPTLRGRSSHVISTIKPLNTYGSLYLVLFDSYEPHKILACAPINKLRPKVASAVFKYAPIFGSINFYQESPLDPTEFNINLNLTSPAAYFYGIDAIPSIKRKKPETKKCPNIKETIFNPNSLDSENIPFEGQGTTDQYAIGDLSGKFCSISYSAPSPNYKPGYNQPIKVLNLYGNDYNLPLFGKNSVVGRALVFYDLEGNAVSCANIDLLGGNMNTAYATFDQPIQGQFIFRQSANYCNDEVFVYVEISKPDSLNAYRTDNHGWHIHDYPVKTGFETLSTTQCDAAGGHFNPYNVSVDATYLRDCTSLTNERCERGDTTSKLSPISITPYKPITYIENGEKKAYSEPEVFKIYLVDSDLSLCGPNSIVGKSIVVHDKHFSSPRISCANILEFKTKN", "length": 1663, "molWeight": 189063, "crc64": "EAC6875C101B809E", "md5": "66CD48EE7754CA3E5D46C1278D61E51D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 3, "Domain": 2, "Binding site": 5, "Site": 1, "Disulfide bond": 2}, "uniParcId": "UPI00324BF39A"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6NDD3", "uniProtkbId": "A0AAU6NDD3_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59773.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59773.1"}], "value": "OR6"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 56, "modifier": "EXACT"}, "end": {"value": 77, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 83, "modifier": "EXACT"}, "end": {"value": 102, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 150, "modifier": "EXACT"}, "end": {"value": 172, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 193, "modifier": "EXACT"}, "end": {"value": 216, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59773.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59773.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420133", "properties": [{"key": "ProteinId", "value": "WWA59773.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "KMERLKKKFLDDESVVCNATKVTDFRHIQIMRFHLNIANGWPGYEVEQKNPKYKNLYSAVQIVLNQFCMSAGIKYLILNLDRSFFELGHMMITSLMGFVAFARILSTLPQRTKYRNLAASFLTKLHLLFFKDSSEYAMKTYKKVHFISQIFTMCVTLQMFAGIALFNCIPMWNNYASGKYKHRVLYNSTFDHTLYLAVPVLKIYTHMEAYVIGWIYNW", "length": 218, "molWeight": 25670, "crc64": "1763C85EF733EE9D", "md5": "EEBD46FF9377E82F4D567312CD129135"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 4, "Non-terminal residue": 1}, "uniParcId": "UPI0035D347AF"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UUA4", "uniProtkbId": "A0AAT9UUA4_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41706.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41706.1"}], "value": "Cytochrome P450 4461K1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 438, "modifier": "EXACT"}, "end": {"value": 438, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41706.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117266", "properties": [{"key": "ProteinId", "value": "WIM41706.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIVTVSFMCLTIAFLYGYFYKLKHRRFYQLLEQFPSYPRYPIIGNLHLWYGPINGLLSRIAKTLEPHDHLLFWMGPAPRIILKKPVDIMAVLNQCPDRDSLGLTRPWTGTGILSARYEEWKKSKKILMPVFSSEMLSKYADIFNEKSIILVDQLKPLAQTDHEVDVWNHVMNINIEIIVENMVGISLQSAGKSGKDFGLSIARALQSMTRRFFMLWLYPQFIYSMYLKLKGQTNLIRTYRQLPSEILENKLNELKNKADRLDTVDSSKLAIDLLIKRSLQDESFDKARMTDELLQLIGAGMETTALNECFLLLMLAIHQDIQQKVYEEITQLVGDNDTLTPDQMLNELKYLEQCIKETARLYSPVVLTTRRALKDCVLNDNKIIPAGTFIILYFYFAHYDKEIFNNPQKWDPENFTESAEAKRPAGSALIFGYGPHTCPGAKYAMMSVKTQITNILREYHLSTNIKELTDSQLKVDLCVRSRIGYPIKFTSRRKPFQTCNQ", "length": 501, "molWeight": 57951, "crc64": "FAB0659E336BC8C7", "md5": "5D8802C7C4BB4CA797621806AD8EA22D"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D2714A"}, "cluster_size": 5, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI82", "uniProtkbId": "A0AA96MI82_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50099.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50099.1"}], "value": "Obelin-like protein"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 102, "modifier": "EXACT"}, "end": {"value": 137, "modifier": "EXACT"}}, "description": "EF-hand", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50222"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022837"}], "id": "KW-0106", "category": "Ligand", "name": "Calcium"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50099.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460176", "properties": [{"key": "ProteinId", "value": "WNS50099.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005509", "properties": [{"key": "GoTerm", "value": "F:calcium ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00051", "properties": [{"key": "EntryName", "value": "EFh"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.10", "properties": [{"key": "EntryName", "value": "EF-hand"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR011992", "properties": [{"key": "EntryName", "value": "EF-hand-dom_pair"}]}, {"database": "InterPro", "id": "IPR018247", "properties": [{"key": "EntryName", "value": "EF_Hand_1_Ca_BS"}]}, {"database": "InterPro", "id": "IPR002048", "properties": [{"key": "EntryName", "value": "EF_hand_dom"}]}, {"database": "Pfam", "id": "PF13202", "properties": [{"key": "EntryName", "value": "EF-hand_5"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00054", "properties": [{"key": "EntryName", "value": "EFh"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SUPFAM", "id": "SSF47473", "properties": [{"key": "EntryName", "value": "EF-hand"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00018", "properties": [{"key": "EntryName", "value": "EF_HAND_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50222", "properties": [{"key": "EntryName", "value": "EF_HAND_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MADDFLKNEDWVQRMNEKFMWLDTNKNGSLEVDDWKDWVQSIERATNASEDLISKVQRAVDEFCIAIGVTPGKSLSKEQFIREFATFAAAERAIKERGGQPILYKLYGAIYDVIDMNKDGYVTLSEYKAVMKACNYDMNEIFKTFCQMDSDISGKIDRQEMAEYQYRTWIDLQKPKAKKKY", "length": 181, "molWeight": 21156, "crc64": "CBB4EC2619D3F2BC", "md5": "BDA0B344C0EDCC0556DF465C721EAC66"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI002B31006B"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "C0HMC8", "uniProtkbId": "PCM74_BACVE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Bacillus velezensis", "taxonId": 492670, "lineage": ["Bacteria", "Bacillati", "Bacillota", "Bacilli", "Bacillales", "Bacillaceae", "Bacillus", "Bacillus amyloliquefaciens group"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "Reference", "id": "Ref.1"}], "value": "PCM7-4"}}}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "Reference", "id": "Ref.1"}], "value": "Has antibacterial activity against Listeria monocytogenes"}], "commentType": "FUNCTION"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "PCM7-4", "featureId": "PRO_0000461491"}], "keywords": [{"id": "KW-0044", "category": "Molecular function", "name": "Antibiotic"}, {"id": "KW-0929", "category": "Molecular function", "name": "Antimicrobial"}, {"id": "KW-0903", "category": "Technical term", "name": "Direct protein sequencing"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8HFDHOGURVU8L", "citationType": "submission", "authors": ["Haotian M.", "Yuexia D.", "Jinju P.", "Yang L.", "Ruixue P.", "Yuner L.", "Yining Z.", "Xiaohui Z.", "Yi M."], "publicationDate": "AUG-2024", "submissionDatabase": "UniProtKB"}, "referencePositions": ["PROTEIN SEQUENCE", "FUNCTION"], "evidences": [{"evidenceCode": "ECO:0000305"}]}], "uniProtKBCrossReferences": [{"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003924", "properties": [{"key": "GoTerm", "value": "F:GTPase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003746", "properties": [{"key": "GoTerm", "value": "F:translation elongation factor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:1901605", "properties": [{"key": "GoTerm", "value": "P:alpha-amino acid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0042742", "properties": [{"key": "GoTerm", "value": "P:defense response to bacterium"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.50.1100", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "2.40.30.10", "properties": [{"key": "EntryName", "value": "Translation factors"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050055", "properties": [{"key": "EntryName", "value": "EF-Tu_GTPase"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR000795", "properties": [{"key": "EntryName", "value": "T_Tr_GTP-bd_dom"}]}, {"database": "InterPro", "id": "IPR036052", "properties": [{"key": "EntryName", "value": "TrpB-like_PALP_sf"}]}, {"database": "PANTHER", "id": "PTHR43721:SF22", "properties": [{"key": "EntryName", "value": "ELONGATION FACTOR TU, MITOCHONDRIAL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43721", "properties": [{"key": "EntryName", "value": "ELONGATION FACTOR TU-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00009", "properties": [{"key": "EntryName", "value": "GTP_EFTU"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "QANDLDYASLPDSVVEQVRTNGQLALEGDKGELGEQAILSLAQALDTYIPTPERAVTALDTMPSAVGYQPTLAEEMGVLQERYLADTANKGDLSNIPFGTVNLLAYNNYQAYLTMLGKTTDVTGNCELPEGVEMVMPGDNIKNPGVTKYLPTTSYSLPHVNVGTIGHVDHGKTTLTAALTRYLADLVDDAELLELVEMEVRDLLSTYDFPGDDTPIIIGSARVSAAASELAVQLKMAVVHDDTNPTSAAQTNAPWGLARLSSYWGLTLHLPNLTEEQGVTIDEDHPLFIYLPCGIGGAPGGAAYGLKNVFLGSSAGTTREVEHSDKPLHDISYAYLGDARQNWVMTAQTTQAIRLEPSATAGFAGPEFIVNSNQGR", "length": 376, "molWeight": 40229, "crc64": "AFB5A95068B8FD08", "md5": "36463CE80223C75002CB9546AC66C182"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1}, "countByFeatureType": {"Chain": 1}, "uniParcId": "UPI0035D3D898"}, "cluster_size": 1, "family": "Bacillaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLZ4", "uniProtkbId": "A0AAU0QLZ4_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56568.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56568.1"}], "value": "Odorant binding protein/PBP-general odorant binding protein"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56568.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 121, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56568.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56568.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56568.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970307", "properties": [{"key": "ProteinId", "value": "WPO56568.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "PDWSYSAVPQELSSHVQQFKRNMSECLKAVQAKEKKTVKRLSPKPESPIHGECLIACVLARNGVIERRKINKDNLIALVSKFYAKDTKLMKKLEKNLDRCIEMSARYRDDECKLASKLNDC", "length": 121, "molWeight": 13911, "crc64": "0CD4CFC86B07D038", "md5": "CACAA8234E1E158583BD473176B3A8E6"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI00308EA562"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9TYL9", "uniProtkbId": "A0AAT9TYL9_9HEMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Eocanthecona furcellata", "taxonId": 696902, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83467.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Pentatomomorpha", "Pentatomoidea", "Pentatomidae", "Asopinae", "Eocanthecona"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83467.1"}], "value": "Odorant-binding protein 2"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83467.1"}], "value": "OBP2"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043445630"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4EEV3RJ5PT5SU", "citationType": "submission", "authors": ["Pan Y.", "Chen W."], "publicationDate": "OCT-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83467.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP575946", "properties": [{"key": "ProteinId", "value": "WGJ83467.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAATYLVSLLVSATCFFGAFADPVIKDPLAFKNATWAKCQKQENAPDDVMKEFYFFTSTDRLTDYKCVVKCIQEEYGFFLKDGTLNMNLVEKTIKGMWKDPEVQQKLIMVVDKCKNSDPQGTHKCQKNFDLLDCFIKNTKKGKINMGNRKN", "length": 151, "molWeight": 17305, "crc64": "58AEE753DC27A21A", "md5": "285B5E80DA8A0B88E7A222E9CDFD872E"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D330E3"}, "cluster_size": 2, "family": "Pentatomidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHL1", "uniProtkbId": "A0AAQ5BHL1_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519412.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519412.1"}], "value": "Transmembrane protein 181"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519412.1"}], "value": "TMEM181"}}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 30, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHL1"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519412.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "14574404", "citationType": "journal article", "authors": ["Mungall A.J.", "Palmer S.A.", "Sims S.K.", "Edwards C.A.", "Ashurst J.L.", "Wilming L.", "Jones M.C.", "Horton R.", "Hunt S.E.", "Scott C.E.", "Gilbert J.G.", "Clamp M.E.", "Bethel G.", "Milne S.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Andrews T.D.", "Ashwell R.I.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beare D.M.", "Beasley H.", "Beasley O.", "Bird C.P.", "Blakey S.", "Bray-Allen S.", "Brook J.", "Brown A.J.", "Brown J.Y.", "Burford D.C.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Clark S.Y.", "Clark G.", "Clee C.M.", "Clegg S.", "Cobley V.", "Collier R.E.", "Collins J.E.", "Colman L.K.", "Corby N.R.", "Coville G.J.", "Culley K.M.", "Dhami P.", "Davies J.", "Dunn M.", "Earthrowl M.E.", "Ellington A.E.", "Evans K.A.", "Faulkner L.", "Francis M.D.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Ghori M.J.", "Gilby L.M.", "Gillson C.J.", "Glithero R.J.", "Grafham D.V.", "Grant M.", "Gribble S.", "Griffiths C.", "Griffiths M.", "Hall R.", "Halls K.S.", "Hammond S.", "Harley J.L.", "Hart E.A.", "Heath P.D.", "Heathcott R.", "Holmes S.J.", "Howden P.J.", "Howe K.L.", "Howell G.R.", "Huckle E.", "Humphray S.J.", "Humphries M.D.", "Hunt A.R.", "Johnson C.M.", "Joy A.A.", "Kay M.", "Keenan S.J.", "Kimberley A.M.", "King A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.R.", "Lloyd D.M.", "Loveland J.E.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Maslen G.L.", "Matthews L.", "McCann O.T.", "McLaren S.J.", "McLay K.", "McMurray A.", "Moore M.J.", "Mullikin J.C.", "Niblett D.", "Nickerson T.", "Novik K.L.", "Oliver K.", "Overton-Larty E.K.", "Parker A.", "Patel R.", "Pearce A.V.", "Peck A.I.", "Phillimore B.", "Phillips S.", "Plumb R.W.", "Porter K.M.", "Ramsey Y.", "Ranby S.A.", "Rice C.M.", "Ross M.T.", "Searle S.M.", "Sehra H.K.", "Sheridan E.", "Skuce C.D.", "Smith S.", "Smith M.", "Spraggon L.", "Squares S.L.", "Steward C.A.", "Sycamore N.", "Tamlyn-Hall G.", "Tester J.", "Theaker A.J.", "Thomas D.W.", "Thorpe A.", "Tracey A.", "Tromans A.", "Tubby B.", "Wall M.", "Wallis J.M.", "West A.P.", "White S.S.", "Whitehead S.L.", "Whittaker H.", "Wild A.", "Willey D.J.", "Wilmer T.E.", "Wood J.M.", "Wray P.W.", "Wyatt J.C.", "Young L.", "Younger R.M.", "Bentley D.R.", "Coulson A.", "Durbin R.", "Hubbard T.", "Sulston J.E.", "Dunham I.", "Rogers J.", "Beck S."], "citationCrossReferences": [{"database": "PubMed", "id": "14574404"}, {"database": "DOI", "id": "10.1038/nature02055"}], "title": "The DNA sequence and analysis of human chromosome 6.", "publicationDate": "2003", "journal": "Nature", "firstPage": "805", "lastPage": "811", "volume": "425"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519412.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519412.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519412.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL591025", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000714120.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519412.1"}, {"key": "GeneId", "value": "ENSG00000146433.12"}]}, {"database": "HGNC", "id": "HGNC:20958", "properties": [{"key": "GeneName", "value": "TMEM181"}]}, {"database": "OpenTargets", "id": "ENSG00000146433", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000007183", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 6"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0015643", "properties": [{"key": "GoTerm", "value": "F:toxic substance binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR040416", "properties": [{"key": "EntryName", "value": "TMEM181"}]}, {"database": "PANTHER", "id": "PTHR31918", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN 181"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31918:SF1", "properties": [{"key": "EntryName", "value": "TRANSMEMBRANE PROTEIN 181"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQTSAANFSLNNSKKKLLLRQAFP", "length": 59, "molWeight": 6777, "crc64": "FA2FA61450CEF088", "md5": "AA18D75D6621D56FC98CE0B937520A76"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI0032D1F492"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA86IW99", "uniProtkbId": "A0AA86IW99_PHYPO", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 9, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Physarum polycephalum", "commonName": "Many-headed slime mold", "synonyms": ["Badhamia polycephala"], "taxonId": 5791, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96133.1"}], "lineage": ["Eukaryota", "Amoebozoa", "Evosea", "Eumycetozoa", "Myxogastria", "Myxogastromycetidae", "Physariida", "Physaraceae", "Physarum"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96133.1"}], "value": "Trehalose-6-phosphate synthase/phosphatase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96133.1"}], "value": "TPS-TPP"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005409"}], "value": "In the N-terminal section; belongs to the glycosyltransferase 20 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 492, "modifier": "EXACT"}, "end": {"value": 526, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 492, "modifier": "EXACT"}, "end": {"value": 525, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8FNH18LGM7QJ2", "citationType": "submission", "authors": ["Minami Y.", "Morita R.", "Okano S.", "Ishii K.", "Furukawa A.", "Teramoto C."], "title": "Analysis of trehalose synthesis pathway from Physarum polycephalum.", "publicationDate": "FEB-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96133.1"}], "value": "Ai35Xdp246", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDX96133.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC757377", "properties": [{"key": "ProteinId", "value": "BDX96133.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005829", "properties": [{"key": "GoTerm", "value": "C:cytosol"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0003825", "properties": [{"key": "GoTerm", "value": "F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004805", "properties": [{"key": "GoTerm", "value": "F:trehalose-phosphatase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005992", "properties": [{"key": "GoTerm", "value": "P:trehalose biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03788", "properties": [{"key": "EntryName", "value": "GT20_TPS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.50.2000:FF:000010", "properties": [{"key": "EntryName", "value": "Alpha,alpha-trehalose-phosphate synthase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.40.50.1000", "properties": [{"key": "EntryName", "value": "HAD superfamily/HAD-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.70.1020", "properties": [{"key": "EntryName", "value": "Trehalose-6-phosphate phosphatase related protein, domain 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001830", "properties": [{"key": "EntryName", "value": "Glyco_trans_20"}]}, {"database": "InterPro", "id": "IPR036412", "properties": [{"key": "EntryName", "value": "HAD-like_sf"}]}, {"database": "InterPro", "id": "IPR023214", "properties": [{"key": "EntryName", "value": "HAD_sf"}]}, {"database": "InterPro", "id": "IPR003337", "properties": [{"key": "EntryName", "value": "Trehalose_PPase"}]}, {"database": "PANTHER", "id": "PTHR10788:SF106", "properties": [{"key": "EntryName", "value": "BCDNA.GH08860"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10788", "properties": [{"key": "EntryName", "value": "TREHALOSE-6-PHOSPHATE SYNTHASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00982", "properties": [{"key": "EntryName", "value": "Glyco_transf_20"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02358", "properties": [{"key": "EntryName", "value": "Trehalose_PPase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56784", "properties": [{"key": "EntryName", "value": "HAD-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNSPLSSKLIVASNRLPINISRDKEGRWVSGGMSSGGLVAALSGIPRDSFIWLGWAGCVVPPHDEPEVTSLLEAEGCVPVFLSDKIAKDHYNGFSNGILWPLFHYQTEDIEFNDEYYSAYSSANQAFADAIERIYEPGDLIWIHDMHLMLLPRMLRKQLHPADAKLHIGFFLHIPFPTSEVFHVLPWKRELLRGVLDSDLIGFHTYDYASHFLRTCTHVLGMETRPQGVLVQDRLAAVGVFPIGIEPHKFEEKLETVQVQDRIKELEVTFAGKKLIIGIDRLDYIKGIPHRLLGYEAFLRDNPESRGKVVLLQVAVPSRTDVPEYKKLKREIEQLVGRINGTYGNLLENYAPVQYLFRSIDFSELTALYTVADVCFVTSLRDGMNLVSLEYIVCQGAKVNAKDGPGVLILSEFAGASGSLIAGSIVVNPWNTDALSDAVRVALSMDVEGRRSKHDLLYKYATKYTASFWGASFIGELRKFMPLQPGSLPTSPTLRTLLMKSGGSSRANSRPNSRPNSRPASPTSSLKSSLGIMLAREFNPLFLHKPNHRMIGNAFHTSKKRLIVLEYDGVLVPFASLPSLSRPPRKLMATLRALAGLPNTYVYVFTQRDRKTLDNWFAPSYNIGVTGEQGAYLRISAKDREKSDKNEKGEEWENLYPDMDLSWRDLVRSLMQHYTIRTPGAFVEETEVQLVWNYRNAEEPFGSTQARDLHHLLDNVAVAVEVKNKRLAVRPLNITQATPFRRVFAEHREDLDFLFVAGDMGIVDPLLELPEKAFVFGMGKSGIEGKWTMADHEEVGELLDDLANVQL", "length": 807, "molWeight": 90675, "crc64": "2B67E6C53A288725", "md5": "363695079DD348D2BA2963603D096B64"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B2EEBF2"}, "cluster_size": 1, "family": "Physaraceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8L0A7", "uniProtkbId": "A0AAU8L0A7_HALDU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28601.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28601.1"}], "value": "SRF"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 118, "modifier": "EXACT"}, "end": {"value": 178, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 285, "modifier": "EXACT"}, "end": {"value": 431, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 285, "modifier": "EXACT"}, "end": {"value": 305, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 395, "modifier": "EXACT"}, "end": {"value": 418, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-A747NP2RMNMU5", "citationType": "submission", "authors": ["Mikhailov K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28601.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP976975", "properties": [{"key": "ProteinId", "value": "XCN28601.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000987", "properties": [{"key": "GoTerm", "value": "F:cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00266", "properties": [{"key": "EntryName", "value": "MADS_SRF_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.1810.10:FF:000002", "properties": [{"key": "EntryName", "value": "Serum response factor b"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050142", "properties": [{"key": "EntryName", "value": "MADS-box/MEF2_TF"}]}, {"database": "InterPro", "id": "IPR033897", "properties": [{"key": "EntryName", "value": "SRF-like_MADS-box"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR48019", "properties": [{"key": "EntryName", "value": "SERUM RESPONSE FACTOR HOMOLOG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00350", "properties": [{"key": "EntryName", "value": "MADS_BOX_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTQPRPSTSNISTGLVSESITAGSNPPPLSFVNALPPSISFPTITAQHLNVARNMLGQTPQVIDPSLQFSSINSLVDQLNPPPAKQPRMEAPQIAQDADAYDTYDDDDDSKPGSKKTRGRVRIKMEYIQNKLRRYTTFSKRKSGIMKKAYELATLTGTQVMLLVASETGHVYTFATPKLQPMITSESGKALIQTCLNSPDPPFRQDQQGDNIRFSQQGFEETELSYPAMQDIISPKGMMQEVPVTTMSMPTHGAVLGPVVRVPFGMQLQSQHQLPISQGNNMLFGQQFIPSNSAPSHSTMVSSQPSSPPRHVGSPIMTAHSPPTMHRMSPSHTPYSQPSPMPSQPHMTVEDAGSPPSHMAGSPLRQGSPHHFPQEHLLPPLESYDAHHSPHGSPLRQQNYSPMTSSRNPSPVYSNHGSPSHIPMGHPMPRM", "length": 431, "molWeight": 47163, "crc64": "583CD5EA9E2B8264", "md5": "EBD94DD03E9F47CEF3A0E7DF2350E259"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 2, "Compositional bias": 3}, "uniParcId": "UPI0035D2D829"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PB97", "uniProtkbId": "A0AAU6PB97_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20561.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20561.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20561.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20561.1"}], "value": "U_LCTX_82_Cm29", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20561.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480830", "properties": [{"key": "ProteinId", "value": "WXB20561.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "GNTSSFSTAFIVAIFTMSKFLILCFVAALMLAQVSLAEPLEAEEAIGYD", "length": 49, "molWeight": 5232, "crc64": "F2342F659429CC43", "md5": "6329D7838D376EE72435B449A9900FE8"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D27380"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6NDB9", "uniProtkbId": "A0AAU6NDB9_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59735.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59735.1"}], "value": "OBP21"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59735.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 111, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59735.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59735.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420095", "properties": [{"key": "ProteinId", "value": "WWA59735.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "IGLSSSYVQAKTPTFRDSLQPILEACSKLYPAVSSDIVNKATEHGNPNLIHPCFNGCVFKKAGFINEKGEYDTNSALTNLRKLVTHDEQYRKLAEIARQCTSVKDTVSDGE", "length": 111, "molWeight": 12235, "crc64": "A41443BB2311780F", "md5": "32032C1F2DD7F0C72A7BC39C25F65A8E"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D2D4E2"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BGS3", "uniProtkbId": "A0AAQ5BGS3_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518997.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518997.1"}], "value": "Biotinidase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518997.1"}], "value": "BTD"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042970828"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BGS3"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BGS3"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518997.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518997.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16641997", "citationType": "journal article", "authors": ["Muzny D.M.", "Scherer S.E.", "Kaul R.", "Wang J.", "Yu J.", "Sudbrak R.", "Buhay C.J.", "Chen R.", "Cree A.", "Ding Y.", "Dugan-Rocha S.", "Gill R.", "Gunaratne P.", "Harris R.A.", "Hawes A.C.", "Hernandez J.", "Hodgson A.V.", "Hume J.", "Jackson A.", "Khan Z.M.", "Kovar-Smith C.", "Lewis L.R.", "Lozado R.J.", "Metzker M.L.", "Milosavljevic A.", "Miner G.R.", "Morgan M.B.", "Nazareth L.V.", "Scott G.", "Sodergren E.", "Song X.Z.", "Steffen D.", "Wei S.", "Wheeler D.A.", "Wright M.W.", "Worley K.C.", "Yuan Y.", "Zhang Z.", "Adams C.Q.", "Ansari-Lari M.A.", "Ayele M.", "Brown M.J.", "Chen G.", "Chen Z.", "Clendenning J.", "Clerc-Blankenburg K.P.", "Chen R.", "Chen Z.", "Davis C.", "Delgado O.", "Dinh H.H.", "Dong W.", "Draper H.", "Ernst S.", "Fu G.", "Gonzalez-Garay M.L.", "Garcia D.K.", "Gillett W.", "Gu J.", "Hao B.", "Haugen E.", "Havlak P.", "He X.", "Hennig S.", "Hu S.", "Huang W.", "Jackson L.R.", "Jacob L.S.", "Kelly S.H.", "Kube M.", "Levy R.", "Li Z.", "Liu B.", "Liu J.", "Liu W.", "Lu J.", "Maheshwari M.", "Nguyen B.V.", "Okwuonu G.O.", "Palmeiri A.", "Pasternak S.", "Perez L.M.", "Phelps K.A.", "Plopper F.J.", "Qiang B.", "Raymond C.", "Rodriguez R.", "Saenphimmachak C.", "Santibanez J.", "Shen H.", "Shen Y.", "Subramanian S.", "Tabor P.E.", "Verduzco D.", "Waldron L.", "Wang J.", "Wang J.", "Wang Q.", "Williams G.A.", "Wong G.K.", "Yao Z.", "Zhang J.", "Zhang X.", "Zhao G.", "Zhou J.", "Zhou Y.", "Nelson D.", "Lehrach H.", "Reinhardt R.", "Naylor S.L.", "Yang H.", "Olson M.", "Weinstock G.", "Gibbs R.A."], "citationCrossReferences": [{"database": "PubMed", "id": "16641997"}, {"database": "DOI", "id": "10.1038/nature04728"}], "title": "The DNA sequence, annotation and analysis of human chromosome 3.", "publicationDate": "2006", "journal": "Nature", "firstPage": "1194", "lastPage": "1198", "volume": "440"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518997.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518997.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC027129", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AC090950", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BGS3", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000713693.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518997.1"}, {"key": "GeneId", "value": "ENSG00000169814.18"}]}, {"database": "HGNC", "id": "HGNC:1122", "properties": [{"key": "GeneName", "value": "BTD"}]}, {"database": "OpenTargets", "id": "ENSG00000169814", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000013823", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 3"}]}], "sequence": {"value": "MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKARMLLGT", "length": 90, "molWeight": 9866, "crc64": "DE84CFF85C043252", "md5": "0CDD3CF8883FD3CC155D0D838C89CB17"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0032D105C9"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LI00", "uniProtkbId": "A0AAN0LI00_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34110.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34110.1"}], "value": "Pyrokinin receptor GPCR protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 188, "modifier": "EXACT"}, "end": {"value": 214, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 226, "modifier": "EXACT"}, "end": {"value": 244, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 264, "modifier": "EXACT"}, "end": {"value": 286, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 307, "modifier": "EXACT"}, "end": {"value": 331, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 351, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 206, "modifier": "EXACT"}, "end": {"value": 387, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}, {"type": "Region", "location": {"start": {"value": 608, "modifier": "EXACT"}, "end": {"value": 627, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34110.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155036", "properties": [{"key": "ProteinId", "value": "WRW34110.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0001607", "properties": [{"key": "GoTerm", "value": "F:neuromedin U receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR005390", "properties": [{"key": "EntryName", "value": "NeuromedU_rcpt"}]}, {"database": "PANTHER", "id": "PTHR24243", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24243:SF208", "properties": [{"key": "EntryName", "value": "PYROKININ-1 RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "PRINTS", "id": "PR01565", "properties": [{"key": "EntryName", "value": "NEUROMEDINUR"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSFWLKKNNCAAISSNYHLFIFHKFTIRRTSILLKYHFFIFTLLFVFNNCLYSYDNLKVPSKYSIKSISNDQNVQSKNKKFSDNSKQVLVKNLALKKYKFENNFNKIDKNSNVNHNLKFSDKKIKRIKRRALNQLNDSNIDKFLNENNDTDFQNYTGLFQNWLKDSIKANDENFENIDTLTTKDSLSMAIFMTILYFVVFLTGVTGNVGTCIVILRNKYMRTATNYYLFSLAVSDLTLLVFGLPQDLYLLWRPYPYIFGEVFCILRGLTCEASSNASILTITAFTIERYLAICYPLKAHTMSKLNRVVKLVFLIWIASALFALPLALQFGIKLEKVELSLPESALCTIKNPIVYSFEISTFFFFVIPLCLLTVLYIKIGIQLRRSEKCITRQNLNTNYHQGNLSPNESLLLATVNAPPSSPSSFNISPNENDSKNIQNSKKYKNFFRIIRRYFNTVFKLNDDKKKNYFKKENVFYLDKIKNKTVDSNSFYNKKITENDESMKKKFDSLNDEIHSLEIEKFNDSNNNFKENKFIVTVEKTDTLECNLKLKNSSQNLEDDKDDFIDSEEKKCMIDQKDINLSKVNDKKIIENIADKKKQLKKMNLFGTSDSTSSNGLNKKNLPFKKNTTLNSQDSNVSLTFKKRNWKFFENRSHSTRTIYHSSSSRRAVVKMLGM", "length": 673, "molWeight": 78353, "crc64": "78416F480D4C00E7", "md5": "0DE8E7BDFBB3B584B7529685DF0A7DE0"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6, "Domain": 1, "Region": 1}, "uniParcId": "UPI0032504A73"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LVZ6", "uniProtkbId": "A0AAN0LVZ6_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34078.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34078.1"}], "value": "Ionotropic receptor 25a"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 956, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043020774"}, {"type": "Transmembrane", "location": {"start": {"value": 574, "modifier": "EXACT"}, "end": {"value": 595, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 648, "modifier": "EXACT"}, "end": {"value": 671, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 872, "modifier": "EXACT"}, "end": {"value": 896, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 445, "modifier": "EXACT"}, "end": {"value": 849, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00079"}]}, {"type": "Domain", "location": {"start": {"value": 455, "modifier": "EXACT"}, "end": {"value": 518, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor L-glutamate and glycine-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00918"}]}, {"type": "Binding site", "location": {"start": {"value": 527, "modifier": "EXACT"}, "end": {"value": 527, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 529, "modifier": "EXACT"}, "end": {"value": 529, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 534, "modifier": "EXACT"}, "end": {"value": 534, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 786, "modifier": "EXACT"}, "end": {"value": 786, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Site", "location": {"start": {"value": 678, "modifier": "EXACT"}, "end": {"value": 678, "modifier": "EXACT"}}, "description": "Crucial to convey clamshell closure to channel opening", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Site", "location": {"start": {"value": 832, "modifier": "EXACT"}, "end": {"value": 832, "modifier": "EXACT"}}, "description": "Interaction with the cone snail toxin Con-ikot-ikot", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 798, "modifier": "EXACT"}, "end": {"value": 857, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34078.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34078.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155004", "properties": [{"key": "ProteinId", "value": "WRW34078.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043226", "properties": [{"key": "GoTerm", "value": "C:organelle"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0038023", "properties": [{"key": "GoTerm", "value": "F:signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000078", "properties": [{"key": "EntryName", "value": "glutamate receptor ionotropic, NMDA 3B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.287.70:FF:000143", "properties": [{"key": "EntryName", "value": "Probable glutamate receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR001508", "properties": [{"key": "EntryName", "value": "Iono_Glu_rcpt_met"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR013099", "properties": [{"key": "EntryName", "value": "K_chnl_dom"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07885", "properties": [{"key": "EntryName", "value": "Ion_trans_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00177", "properties": [{"key": "EntryName", "value": "NMDARECEPTOR"}]}, {"database": "SMART", "id": "SM00918", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81324", "properties": [{"key": "EntryName", "value": "Voltage-gated potassium channels"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFFCNFLIFLILLKKTSTLELAISIEDNDESVIKTVNKAISEHKIVDINVTNLKIIKANNSLTKNQIYEKLIFNNTKPILLIDTTKKNFISNSFSSKIKELVREIGLPTISTGVNSGKSFKPIEQWKSLSNEEEKIFLDFSSTNQQIEMIISDLIKNFNPSLAVLLYDDQFNLDDKYSFLFKNFKGKYLAKKINDENCEEVIKKIKIYEKGYFFVLASLDLSMKILENLSVEKLLTVQRNWYFITKNIGVLNCNNCNYGSITLIQPLKTKQLIYDHNCTISKFNSKLTKLDVYFYYDLIRFILLTISEIKKNLIKNKIDLDINNFFLNKSIKPEEKNKLIKYLDFRYIMSMESFTGHYGRFVVLPSKKHNNFPNYQELTMRLSKIEFWIDKDEKKNLIESQYSNSDDTEKKSYLKLIKYGEWIFEPYKGVFVWTAALLQNSFKKHYKIVTIVQPPFIMKRINGNQIEWYGYCLDLLYGMQKEMNNSWTFEMYEVPDGQCGIKDLVTNKWNGIIGQLADSLADIAVGPVSVMAERENVVDFTVPYYDLVGISILMKKSASRPHLFKFLTVLENQVWLYIFFAYVVTSLILWIFDLLSPYSFNNNREKYQNSLEKRDFNIKECFWFCMTSITPQGGGEAPKNLSGRMVCAVWWTFGFIIIACYTANLAAFLTVSRLDSPIESLNHLADQYRIRYAAQVGTQALTYFERMAHIEVKFYEIWKQISLEETNIVDVRERARMSVWDYPITDKYTKILKQMYISGLPKTFDEGVRRVKKSKSAQEGFAFLADATKIKYAAMINCELRQVGNEFSRKPLALAVPENSTLKDTLSSAILKLLNQRKLESLKEKWWNDNPDRKEDCDYDKKSNDGISINNIGGVFVVIFVGVILACITLFFEWIWKKIKGSKFKTTVVNIQNINQSDFNHPSIIFNTKKDPSRIVNIKNYPSNIYKRPKNLQHYN", "length": 956, "molWeight": 111418, "crc64": "E8D11D35E42A5843", "md5": "9F9DB7703401F9C30F022658ADEFB664"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 3, "Domain": 2, "Binding site": 4, "Site": 2, "Disulfide bond": 1}, "uniParcId": "UPI0032438DD2"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QM14", "uniProtkbId": "A0AAU0QM14_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56555.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56555.1"}], "value": "Odorant binding protein/PBP-general odorant binding protein"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008098"}], "value": "Belongs to the PBP/GOBP family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56555.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56555.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56555.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970294", "properties": [{"key": "ProteinId", "value": "WPO56555.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006072", "properties": [{"key": "EntryName", "value": "Odorant/phero-bd_Lep"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00484", "properties": [{"key": "EntryName", "value": "PBPGOBP"}]}, {"database": "SMART", "id": "SM00708", "properties": [{"key": "EntryName", "value": "PhBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MHFGKDILVDMLHFWQPDYKFSKKAIGCSLMCASIKLKLVDVDGAVLAPNILAFVKASGADDEVANTILKLYQTCLDLSKKTDLCDKALEASACFREAMKDSTWRPVMPVTL", "length": 112, "molWeight": 12415, "crc64": "2F0BB447BA74C4ED", "md5": "5FCFAA1D2A9400FE465E3E8296FBBEE4"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI00308C12E1"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QJW6", "uniProtkbId": "A0AAU0QJW6_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56482.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56482.1"}], "value": "Odorant receptor"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 47, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 105, "modifier": "EXACT"}, "end": {"value": 128, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56482.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56482.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56482.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970375", "properties": [{"key": "ProteinId", "value": "WPO56482.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MFYYKVSVKELIDEISYDYLCYNNLPDRYQNVIYSRVNACMVYTERLWIITLGVAVGAFPLMAALTTLYSQIFDDIPKKYMVHDLNIPFTEPETRFESPYFEIMFFYLTGCAATWFINYACEYVLVYFDTNSHFIFFQTI", "length": 140, "molWeight": 16703, "crc64": "D93809432241E10E", "md5": "BF798B7143BD2BFB1D1213535FB1C2AA"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2}, "uniParcId": "UPI003091A0BA"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI42", "uniProtkbId": "A0AA96MI42_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50071.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50071.1"}], "value": "Alpha-glucosidase"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007806"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361185"}], "value": "Belongs to the glycosyl hydrolase 31 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 599, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041672303"}, {"type": "Domain", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 360, "modifier": "EXACT"}}, "description": "Glycoside hydrolase family 31 TIM barrel", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01055"}]}, {"type": "Domain", "location": {"start": {"value": 396, "modifier": "EXACT"}, "end": {"value": 458, "modifier": "EXACT"}}, "description": "Glycosyl hydrolase family 31 C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF21365"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023295"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361185"}], "id": "KW-0326", "category": "Molecular function", "name": "Glycosidase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU361185"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50071.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460148", "properties": [{"key": "ProteinId", "value": "WNS50071.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004553", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity, hydrolyzing O-glycosyl compounds"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd06597", "properties": [{"key": "EntryName", "value": "GH31_transferase_CtsY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.20.20.80", "properties": [{"key": "EntryName", "value": "Glycosidases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.1180", "properties": [{"key": "EntryName", "value": "Golgi alpha-mannosidase II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050985", "properties": [{"key": "EntryName", "value": "Alpha-glycosidase_related"}]}, {"database": "InterPro", "id": "IPR048395", "properties": [{"key": "EntryName", "value": "Glyco_hydro_31_C"}]}, {"database": "InterPro", "id": "IPR000322", "properties": [{"key": "EntryName", "value": "Glyco_hydro_31_TIM"}]}, {"database": "InterPro", "id": "IPR013780", "properties": [{"key": "EntryName", "value": "Glyco_hydro_b"}]}, {"database": "InterPro", "id": "IPR017853", "properties": [{"key": "EntryName", "value": "Glycoside_hydrolase_SF"}]}, {"database": "PANTHER", "id": "PTHR43053", "properties": [{"key": "EntryName", "value": "GLYCOSIDASE FAMILY 31"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43053:SF4", "properties": [{"key": "EntryName", "value": "MYOGENESIS-REGULATING GLYCOSIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01055", "properties": [{"key": "EntryName", "value": "Glyco_hydro_31_2nd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF21365", "properties": [{"key": "EntryName", "value": "Glyco_hydro_31_3rd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF51445", "properties": [{"key": "EntryName", "value": "(Trans)glycosidases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF51011", "properties": [{"key": "EntryName", "value": "Glycosyl hydrolase domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKTLSCIVFASAIALALCLDDFVVPPADLDPSAYPEWAHYHWVWLDHSRSSQDNVMEYVNEYKSRNITVGAVNIDSGWSTGYNNFIVDTKKFPNASNLVDDLHKMNIRVILWATSVVDTTSSNYQEAHDKGYFLKDILGQQAIIDWWHGKGGMVDYTNPDAVKWWHGQMDKAIELGIDGWKCDGTDPYVLLIPDATGKSGHVTRRQYSDAYYEDFFDYIRSKTGRTDKLIMSRPVDEEGPIYLKFSPKRVMISGWVGDQDPTFEGLQGCLRRYLQSAWAGYANFGSDIGGYRSGNGTLGRSKELFIRWAQLGAFSPLMENGGNKEHRPWMFDTPGDKNETANIYRKLVDDHYQLIPYFLTIGSEALRKGTSSIHPLAKHDSFINKAIDLFHPSTFNYLLGSSFLVVPISAEGGSAEVTFPDGHWVARWNTSSMYKGGETASFKNLPLEIFPVFLKTNGLIPLRITPMTPVLGKFPCLHDKLRFVLHRPSHTLHPVKSSVIEDQGTGLEAYHWMDKAGMLHINATAHPTMVVVVEIHGCQTAREELILFSESGHNALKPSLREEDMLSGSHYFVSKEENCLFINLGSLKRGAYAHLFCDK", "length": 599, "molWeight": 67472, "crc64": "DC651FEA3F7A2F10", "md5": "47529D73078647E15F002C545941907E"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2}, "uniParcId": "UPI002B2B5D58"}, "cluster_size": 2, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZE76", "uniProtkbId": "A0AB38ZE76_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71726.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71726.1"}], "value": "Heteropteran venom family 6 protein 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044312198"}, {"type": "Coiled coil", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 62, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71726.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510801", "properties": [{"key": "ProteinId", "value": "WXH71726.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MYKFICLIAALCVAVQALDEKKINDELEFYTKEIASLKKEDINRCKQIINSKEQLAQEAKGEEGENCVRSAGEKLITDVRTNQEKETFDFLIHVEGLKQDMKNGKGEQVEKTIESKTRKDFQHVITNMQAKDEMLILAFVSEANKCRGLDH", "length": 151, "molWeight": 17284, "crc64": "88E0D03F583F59CF", "md5": "B0D40E7BA6A00137805CFB5CC8581F5A"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Coiled coil": 1}, "uniParcId": "UPI00388C2E69"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2G8", "uniProtkbId": "A0AA96S2G8_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50073.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50073.1"}], "value": "Uncharacterized protein 13"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 165, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041655478"}, {"type": "Transmembrane", "location": {"start": {"value": 89, "modifier": "EXACT"}, "end": {"value": 117, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50073.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460150", "properties": [{"key": "ProteinId", "value": "WNS50073.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MQAQKLKRFLLLALLVPEVLRSCDAVSLAGSASQSSAYAAEEARAENEPLPLIDIQPVPEPTGNTEVISFRNVQPWVPKPTSTGSTEAAGFPLVVVVLGVGCVALVVELVTLCACVLRRARKAWRKRREEQEDILNILFDVQMSGMKAMVNPVVLWSNGKENSSC", "length": 165, "molWeight": 17932, "crc64": "7C20FACCF8987401", "md5": "ADF770673EDF4121CFFE6D3B3BE23B54"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1}, "uniParcId": "UPI002B2B8818"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7E8Z9", "uniProtkbId": "A0AAU7E8Z9_TERTR", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Terebratalia transversa", "commonName": "Transverse lampshell", "taxonId": 34513, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48608.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Brachiopoda", "Rhynchonelliformea", "Rhynchonellata", "Terebratellidina", "Laqueoidea", "Laqueidae", "Terebratalia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48608.1"}], "value": "Wnt inhibitory factor protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48608.1"}], "value": "wif"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 370, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043380565"}, {"type": "Domain", "location": {"start": {"value": 39, "modifier": "EXACT"}, "end": {"value": 175, "modifier": "EXACT"}}, "description": "WIF", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50814"}]}, {"type": "Domain", "location": {"start": {"value": 216, "modifier": "EXACT"}, "end": {"value": 248, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 280, "modifier": "EXACT"}, "end": {"value": 312, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Region", "location": {"start": {"value": 348, "modifier": "EXACT"}, "end": {"value": 370, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 220, "modifier": "EXACT"}, "end": {"value": 230, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 238, "modifier": "EXACT"}, "end": {"value": 247, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 284, "modifier": "EXACT"}, "end": {"value": 294, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 302, "modifier": "EXACT"}, "end": {"value": 311, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022536"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-0245", "category": "Domain", "name": "EGF-like domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AKIT4T8HERMEG", "citationType": "submission", "authors": ["Vellutini B.C.", "Martin-Duran J.M.", "Borve A.", "Hejnol A."], "title": "Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48608.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP860515", "properties": [{"key": "ProteinId", "value": "XBK48608.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0009986", "properties": [{"key": "GoTerm", "value": "C:cell surface"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005102", "properties": [{"key": "GoTerm", "value": "F:signaling receptor binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000020", "properties": [{"key": "EntryName", "value": "Latent-transforming growth factor beta-binding protein 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.10.25.10", "properties": [{"key": "EntryName", "value": "Laminin"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Gene3D", "id": "2.60.40.2170", "properties": [{"key": "EntryName", "value": "Wnt, WIF domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050969", "properties": [{"key": "EntryName", "value": "Dev_Signal_Modulators"}]}, {"database": "InterPro", "id": "IPR013032", "properties": [{"key": "EntryName", "value": "EGF-like_CS"}]}, {"database": "InterPro", "id": "IPR000742", "properties": [{"key": "EntryName", "value": "EGF-like_dom"}]}, {"database": "InterPro", "id": "IPR003306", "properties": [{"key": "EntryName", "value": "WIF"}]}, {"database": "InterPro", "id": "IPR038677", "properties": [{"key": "EntryName", "value": "WIF_sf"}]}, {"database": "PANTHER", "id": "PTHR14949", "properties": [{"key": "EntryName", "value": "EGF-LIKE-DOMAIN, MULTIPLE 7, 8"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14949:SF32", "properties": [{"key": "EntryName", "value": "WNT INHIBITORY FACTOR 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF25024", "properties": [{"key": "EntryName", "value": "EGF_TEN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF12661", "properties": [{"key": "EntryName", "value": "hEGF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02019", "properties": [{"key": "EntryName", "value": "WIF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00181", "properties": [{"key": "EntryName", "value": "EGF"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "SMART", "id": "SM00469", "properties": [{"key": "EntryName", "value": "WIF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57196", "properties": [{"key": "EntryName", "value": "EGF/Laminin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00022", "properties": [{"key": "EntryName", "value": "EGF_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS01186", "properties": [{"key": "EntryName", "value": "EGF_2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50026", "properties": [{"key": "EntryName", "value": "EGF_3"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50814", "properties": [{"key": "EntryName", "value": "WIF"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRGLVPTLLFLVGLLMKDSFGRQYRNRYRSRTRISLLSMWIDETQMAEFLGRPMKIPIVNNGIVLPYFKNKGFFQSLPVIPPEIDVVRLRWVARIDQYSYWFQNLKSEDDEILYKPLLSIPLTGRIPPKETEFQIAIPCTGKKSGIVAFEIDVYIFRQNIPISGSPIKLRLSKRCKALNPGKTQRSICNLDCQNGGICSQQKTCICMQGYSGKLCEKATCSPVCLNNGSCIAPNQCKCQHGYAGSNCERAKCSRPCYNGGRCIGPDQCLCSKGFHGLNCQLSSCGYPCSNGGRCMGQNNCVCPTGYGGQLCEIPKCYRSCGLHGMCVDVGVCRCELGWHGRYCNKKSKHNRHHRKRRKDRKKRNRKHLSR", "length": 370, "molWeight": 41821, "crc64": "88BF0D660AF6FCD4", "md5": "D65F541BB492D35CC16D54F8D3D96FE6"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 3, "Region": 1, "Disulfide bond": 4}, "uniParcId": "UPI0035D2FB59"}, "cluster_size": 1, "family": "Laqueidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39JAS4", "uniProtkbId": "A0AB39JAS4_SALZA", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Salacca zalacca", "commonName": "Snake palm", "synonyms": ["Salacca edulis"], "taxonId": 145711, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89000.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Liliopsida", "Arecaceae", "Calamoideae", "Calameae", "Salaccinae", "Salacca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89000.1"}], "value": "Early responsive to dehydration 15"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89000.1"}], "value": "ERD15"}}], "features": [{"type": "Region", "location": {"start": {"value": 76, "modifier": "EXACT"}, "end": {"value": 99, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 99, "modifier": "EXACT"}, "end": {"value": 99, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89000.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9V2V54QP4C7C3", "citationType": "submission", "authors": ["Tong W."], "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN89000.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ120708", "properties": [{"key": "ProteinId", "value": "XDN89000.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR040414", "properties": [{"key": "EntryName", "value": "CID1/CID2"}]}, {"database": "PANTHER", "id": "PTHR33790", "properties": [{"key": "EntryName", "value": "OS05G0344200 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR33790:SF1", "properties": [{"key": "EntryName", "value": "PROTEIN EARLY RESPONSIVE TO DEHYDRATION 15"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDVISGRMGSGLNPDAAPYVPEAYRAVEDFSAEWWELVHTSPWFRDYWLRESFYETQNDPDPFDIYDAAVPDNADSFFSPPRRESPSLPFPLSPLLSSI", "length": 99, "molWeight": 11347, "crc64": "840F4059727491A6", "md5": "8F3DDA529475FD7E5B7893338700FADE"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388BC332"}, "cluster_size": 1, "family": "Arecaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9XZF3", "uniProtkbId": "A0AAT9XZF3_PINTA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pinus taeda", "commonName": "Loblolly pine", "taxonId": 3352, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Pinopsida", "Pinidae", "Conifers I", "Pinales", "Pinaceae", "Pinus", "Pinus subgen. Pinus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "value": "RNA helicase SDE3"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "value": "SDE3"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 389, "modifier": "EXACT"}, "end": {"value": 466, "modifier": "EXACT"}}, "description": "DNA2/NAM7 helicase helicase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF13086"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 617, "modifier": "EXACT"}, "end": {"value": 638, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 617, "modifier": "EXACT"}, "end": {"value": 627, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 628, "modifier": "EXACT"}, "end": {"value": 638, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "id": "KW-0347", "category": "Molecular function", "name": "Helicase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-134CKBQBAMOI5", "citationType": "submission", "authors": ["Bragg Z.", "Rieske L.K."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "value": "7-56xOP_17", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "value": "Whole plant", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-CRD440VTN3173", "citationType": "journal article", "authors": ["Bragg Z.", "Rieske L.K."], "title": "Identification of RNAi-Related Genes and Transcriptome Assembly of Loblolly Pine (Pinus taeda, L.) Seedlings Exposed to Insect-Specific dsRNA.", "publicationDate": "2024", "journal": "Forests", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "value": "7-56xOP_17", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}], "value": "Whole plant", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66627.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR466162", "properties": [{"key": "ProteinId", "value": "WLZ66627.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004386", "properties": [{"key": "GoTerm", "value": "F:helicase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR041677", "properties": [{"key": "EntryName", "value": "DNA2/NAM7_AAA_11"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "PANTHER", "id": "PTHR45418:SF5", "properties": [{"key": "EntryName", "value": "BRCA2-INTERACTING PROTEIN-LIKE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45418", "properties": [{"key": "EntryName", "value": "CANCER/TESTIS ANTIGEN 55"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13086", "properties": [{"key": "EntryName", "value": "AAA_11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MASQDIIESSLASSGSKPKGKIWKEKPRAFPQTSVTLSETNWEKFDMAEIEVSFPFPPVDGLVQTVNIGETIATILSIQNPSSSCYARLVAVGIESSQPKGTFTLSYSGSPTSSSSASASASASVSCSQAVNREVISFPGNTGSMEPGRRIALDLSFTPKRPGLSTVTIVVDIGEKEILRTATLFAIGSPPKQKQDSDFPVPEHLKESFRIKRIPEILHKRLSEETYCEYFSTLLYLEDLHLKELSEQSVMVKMREDKRCRLLVVLTLLGGGKKKSGGRAPSTLDYVSVKDPNKKGKEHKGCINKVDKKKKVFVRFEKQFKVISDIEYEARFSFNRSNIIRGHHAIAKIKDLSKSFLFPSKSPSRTVQTLYAEHGETDTGLDTPFNPLLNSDQRNAIMGILNCNGSSPYLVYGEARTGTTATITEAILQIHENNPDARILACTPFNRTSDSLLKRFIGSPIEDTKIFRLNAKFRDLYDEVPEEIYSYCCYNTEEEIYFCPPVNELREYKLIVSTYMSSARLHKSGLPAGHFTHIFLDSAGQASEPETMVPIANFATEQTVVVVSGNLSKLAHEISCPMARKFGLSKSYLKRFTEHPFYSLGHGRGNQQFVTKLEKEFEDPHSDEGRGKGRKLKGVWNA", "length": 638, "molWeight": 70996, "crc64": "C62228C5A4C548CD", "md5": "085EA5DC1294DD663A91C49537AB1FBB"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 2, "Compositional bias": 3}, "uniParcId": "UPI0035D31710"}, "cluster_size": 1, "family": "Pinaceae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXB4", "uniProtkbId": "CGLR_TRIPJ", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Trichogramma pretiosum", "commonName": "Parasitoid wasp", "taxonId": 7493, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Hymenoptera", "Apocrita", "Proctotrupomorpha", "Chalcidoidea", "Trichogrammatidae", "Trichogramma"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Cyclic GMP-AMP synthase-like receptor"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37379839"}], "value": "Tp-cGLR"}], "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}], "value": "2.7.7.86"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37379839"}], "value": "cGLR"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}], "value": "Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:37379839). Directly binds some unknown ligand, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor (PubMed:37379839)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "GTP + ATP = 2',3'-cGAMP + 2 diphosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:42064"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:33019"}, {"database": "ChEBI", "id": "CHEBI:37565"}, {"database": "ChEBI", "id": "CHEBI:143093"}], "ecNumber": "2.7.7.86", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:42065"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}]}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "GTP + ATP = pppGp(2'-5')A + diphosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:23748"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:33019"}, {"database": "ChEBI", "id": "CHEBI:37565"}, {"database": "ChEBI", "id": "CHEBI:78318"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:23749"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}]}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "pppGp(2'-5')A = 2',3'-cGAMP + diphosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:23924"}, {"database": "ChEBI", "id": "CHEBI:33019"}, {"database": "ChEBI", "id": "CHEBI:78318"}, {"database": "ChEBI", "id": "CHEBI:143093"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:23925"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}]}, {"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}, {"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the mab-21 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 485, "modifier": "EXACT"}}, "description": "Cyclic GMP-AMP synthase-like receptor", "featureId": "PRO_0000460027"}, {"type": "Binding site", "location": {"start": {"value": 70, "modifier": "EXACT"}, "end": {"value": 70, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 82, "modifier": "EXACT"}, "end": {"value": 84, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 82, "modifier": "EXACT"}, "end": {"value": 82, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 84, "modifier": "EXACT"}, "end": {"value": 84, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 204, "modifier": "EXACT"}, "end": {"value": 204, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:37565"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "GTP", "id": "ChEBI:CHEBI:37565"}}, {"type": "Binding site", "location": {"start": {"value": 204, "modifier": "EXACT"}, "end": {"value": 204, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 247, "modifier": "EXACT"}, "end": {"value": 254, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:37565"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "GTP", "id": "ChEBI:CHEBI:37565"}}, {"type": "Binding site", "location": {"start": {"value": 271, "modifier": "EXACT"}, "end": {"value": 271, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 274, "modifier": "EXACT"}, "end": {"value": 274, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 298, "modifier": "EXACT"}, "end": {"value": 298, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29035"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "ligand": {"name": "Mn(2+)", "id": "ChEBI:CHEBI:29035"}}, {"type": "Binding site", "location": {"start": {"value": 304, "modifier": "EXACT"}, "end": {"value": 304, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29035"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "ligand": {"name": "Mn(2+)", "id": "ChEBI:CHEBI:29035"}}], "keywords": [{"id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"id": "KW-0342", "category": "Ligand", "name": "GTP-binding"}, {"id": "KW-0391", "category": "Biological process", "name": "Immunity"}, {"id": "KW-0399", "category": "Biological process", "name": "Innate immunity"}, {"id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"id": "KW-0464", "category": "Ligand", "name": "Manganese"}, {"id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"id": "KW-0548", "category": "Molecular function", "name": "Nucleotidyltransferase"}, {"id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7QD46N220UPID", "citationType": "submission", "authors": ["Murali S.", "Richards S.", "Bandaranaike D.", "Bellair M.", "Blankenburg K.", "Chao H.", "Dinh H.", "Doddapaneni H.", "Dugan-Rocha S.", "Elkadiri S.", "Gnanaolivu R.", "Hernandez B.", "Skinner E.", "Javaid M.", "Lee S.", "Li M.", "Ming W.", "Munidasa M.", "Muniz J.", "Nguyen L.", "Hughes D.", "Osuji N.", "Pu L.-L.", "Puazo M.", "Qu C.", "Quiroz J.", "Raj R.", "Weissenberger G.", "Xin Y.", "Zou X.", "Han Y.", "Worley K.", "Muzny D.", "Gibbs R."], "publicationDate": "JAN-2014", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}, {"referenceNumber": 2, "citation": {"id": "37379839", "citationType": "journal article", "authors": ["Li Y.", "Slavik K.M.", "Toyoda H.C.", "Morehouse B.R.", "de Oliveira Mann C.C.", "Elek A.", "Levy S.", "Wang Z.", "Mears K.S.", "Liu J.", "Kashin D.", "Guo X.", "Mass T.", "Sebe-Pedros A.", "Schwede F.", "Kranzusch P.J."], "citationCrossReferences": [{"database": "PubMed", "id": "37379839"}, {"database": "DOI", "id": "10.1016/j.cell.2023.05.038"}], "title": "cGLRs are a diverse family of pattern recognition receptors in innate immunity.", "publicationDate": "2023", "journal": "Cell", "firstPage": "3261", "lastPage": "3276", "volume": "186"}, "referencePositions": ["FUNCTION", "CATALYTIC ACTIVITY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "JARR02001022", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "P0DXB4", "properties": [{"key": "Description", "value": "-"}]}, {"database": "KEGG", "id": "tpre:106649006", "properties": [{"key": "Description", "value": "-"}]}, {"database": "OMA", "id": "ANLKSYH", "properties": [{"key": "Fingerprint", "value": "-"}]}, {"database": "GO", "id": "GO:0061501", "properties": [{"key": "GoTerm", "value": "F:2',3'-cyclic GMP-AMP synthase activity"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "37379839"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0045087", "properties": [{"key": "GoTerm", "value": "P:innate immune response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.10.1410.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.460.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR046903", "properties": [{"key": "EntryName", "value": "Mab-21-like_nuc_Trfase"}]}, {"database": "InterPro", "id": "IPR046906", "properties": [{"key": "EntryName", "value": "Mab-21_HhH/H2TH-like"}]}, {"database": "InterPro", "id": "IPR024810", "properties": [{"key": "EntryName", "value": "MAB21L/cGLR"}]}, {"database": "PANTHER", "id": "PTHR10656", "properties": [{"key": "EntryName", "value": "CELL FATE DETERMINING PROTEIN MAB21-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10656:SF42", "properties": [{"key": "EntryName", "value": "CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03281", "properties": [{"key": "EntryName", "value": "Mab-21"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF20266", "properties": [{"key": "EntryName", "value": "Mab-21_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01265", "properties": [{"key": "EntryName", "value": "Mab-21"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVDENLYRIKKYSDDTAFSCISKHFITLKDEEIKANNQHLHNVVSQGLIPLMKEDTLFKDIYRNIKYEGSYFKGTKVAKPDEYDLNLSMKLPLNYNELQVETNHKHFSYVKIKVNSESKLPKWEEHSKILNKWLSDKNYLNQNKFHQWMEAIMTNTYKKLKKSDNFYELEVDGKNYRIKQFKKSGPAFTIFVELGDHPTLMSMDIVPCLELNDIILQGYKTFPDVSPSKCVVAKPISKEPEGEFLWRLSFYEQEKQILSNSEVSKLKVVVKMIKKLRDQLNYKPLASYYIETIFLHEIAKRKSDVDFFRASKTSLFIYMLQKLIQALEKKCIPYFWHEGHNLIGHLQPPVIENYANRLKNILLSIDKKIVDDRFAMAEFLLNEEEKKNLLEIVESSKTNGSDTQNLEKSEVIKKIKHVINDGKNKENQNSFATIVTHAIIDRKENDLERRIAFVCEELKNLGQMKEQIPLADLNKLSESFKIMFS", "length": 485, "molWeight": 56923, "crc64": "1E63108AD9B32A7D", "md5": "99C5681A700C5E7723798FC0795BAEC9"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 3, "COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Binding site": 11}, "uniParcId": "UPI0006C97961"}, "cluster_size": 2, "family": "Trichogrammatidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8HXH0", "uniProtkbId": "A0AAU8HXH0_PENIN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Penaeus indicus", "commonName": "Indian white prawn", "synonyms": ["Fenneropenaeus indicus"], "taxonId": 29960, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI48944.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Dendrobranchiata", "Penaeoidea", "Penaeidae", "Penaeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI48944.1"}], "value": "Hemocyanin subunit-like antimicrobial peptide"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI48944.1"}], "value": "HEM"}}], "features": [{"type": "Domain", "location": {"start": {"value": 3, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "Hemocyanin middle", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00372"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI48944.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 61, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI48944.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FOFQLOJIRTOK9", "citationType": "submission", "authors": ["Naveenkumar R.", "Panigrahi A.", "Bedekar M.", "Saranya C."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI48944.1"}], "value": "APMNHE-PI3", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI48944.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP982468", "properties": [{"key": "ProteinId", "value": "XCI48944.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.1280.10", "properties": [{"key": "EntryName", "value": "Di-copper center containing domain from catechol oxidase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008922", "properties": [{"key": "EntryName", "value": "Di-copper_centre_dom_sf"}]}, {"database": "InterPro", "id": "IPR000896", "properties": [{"key": "EntryName", "value": "Hemocyanin/hexamerin_mid_dom"}]}, {"database": "Pfam", "id": "PF00372", "properties": [{"key": "EntryName", "value": "Hemocyanin_M"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48056", "properties": [{"key": "EntryName", "value": "Di-copper centre-containing domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "YGHHLDRKGENFFWVHHQLTVRFDAERLSNYLDLVDELHWEKPIVQGFAPHTTYKYGGQFP", "length": 61, "molWeight": 7342, "crc64": "D0900D41B4E0C32C", "md5": "C501A0018D0AA13D3529B12D8398110E"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D28C15"}, "cluster_size": 1, "family": "Penaeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0MWD5", "uniProtkbId": "A0AAU0MWD5_UREUN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Urechis unicinctus", "commonName": "Fat innkeeper worm", "synonyms": ["Chinese penis fish"], "taxonId": 6432, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59944.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Echiura", "Xenopneusta", "Urechidae", "Urechis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59944.1"}], "value": "Heat shock protein family A member 12 variant X5"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59944.1"}], "value": "HSPA12"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007381"}], "value": "Belongs to the heat shock protein 70 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 451, "modifier": "EXACT"}, "end": {"value": 482, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 456, "modifier": "EXACT"}, "end": {"value": 474, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59944.1"}], "id": "KW-0346", "category": "Biological process", "name": "Stress response"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FQL9M4QGPVUS3", "citationType": "submission", "authors": ["Liu D.D."], "publicationDate": "FEB-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOS59944.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OM803165", "properties": [{"key": "ProteinId", "value": "WOS59944.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0140662", "properties": [{"key": "GoTerm", "value": "F:ATP-dependent protein folding chaperone"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd10229", "properties": [{"key": "EntryName", "value": "ASKHA_NBD_HSP70_HSPA12"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.90.640.10", "properties": [{"key": "EntryName", "value": "Actin, Chain A, domain 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR043129", "properties": [{"key": "EntryName", "value": "ATPase_NBD"}]}, {"database": "InterPro", "id": "IPR013126", "properties": [{"key": "EntryName", "value": "Hsp_70_fam"}]}, {"database": "PANTHER", "id": "PTHR14187", "properties": [{"key": "EntryName", "value": "ALPHA KINASE/ELONGATION FACTOR 2 KINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14187:SF5", "properties": [{"key": "EntryName", "value": "HEAT SHOCK 70 KDA PROTEIN 12A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00012", "properties": [{"key": "EntryName", "value": "HSP70"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53067", "properties": [{"key": "EntryName", "value": "Actin-like ATPase domain"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MASSGSGPSDRALDSAYSVVVAIDFGTTYSGYAVSFKKNPDDIFVQNTWGDVMGIPGASKTPSCVLTDKKINCIAVGHKAIKKYINMDSDEAKQHRFYSLFKMTLHTKKTLNKTTMVEDICGNKAPAIDILAMVLAEMKAEMLVALSKQGARDFDVNLIRWVITVPTIWTDVAKRFMQEAAVKADLVDHVDSKKLILSLEPEAASICCQTLPSVKNALKNDSSFVLPVGTKYLVLDAGGGTLDITAHEVLPETQVKELYRSNGGDLGASQVDRLFLELLDEIFDAKFVKLHKTKNPSDCFTNLINRFETVKKSLKSSDGSATTAFRITANIVDLFHTEFKKKLLECVSKKSIERKIVVKNGMIKIPNAVLLAVFQPVVNDIVSYLEDLLKKTKLEGITTILMVGGFSNCDVLQEAIKTKFSDKYSVVIPKEADQVVMKGAVQFGHKPRQRCVFESPAKRPRPDDGERPEGDTTKKMRGPNKTDLWWANCQKRGAI", "length": 495, "molWeight": 54710, "crc64": "F7F2F7B9AE1167BF", "md5": "09B0A3B6895C816C77BC176A03A927F3"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D3BA46"}, "cluster_size": 3, "family": "Urechidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QML2", "uniProtkbId": "A0AAU0QML2_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56474.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56474.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 88, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 114, "modifier": "EXACT"}, "end": {"value": 146, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 210, "modifier": "EXACT"}, "end": {"value": 231, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 243, "modifier": "EXACT"}, "end": {"value": 260, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 300, "modifier": "EXACT"}, "end": {"value": 319, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56474.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56474.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56474.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970367", "properties": [{"key": "ProteinId", "value": "WPO56474.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTISIGVCLLFRNKFRVFLGEMAFKDEMVKMPLIEFILKLENGKKLMELKNLVIESQETLFKYTRLLLKCYVTSVWLVATLYLCSPIYEMIVKGDSSLRLLAFDMWFPWSLDNPVVYCASFIFHAYAGYLCCVAYPGLQLTIILLLGQVIRQLRILTFILKNLPELVTEIVKGKGDQWQMYCTAVLVQCIDHYIKLKRFSNRLNVICQPFYLTLILVAIMLVCMCSVKIAISDKLSPDTIKYYVHEFCFIMVVLMFCLLGQQVDIECADLELAVTEKWYIFDKNHKMDVRIFKTALSQRMPIFIFGSITLSLPTFTWFIKNGMSFFTLVMSVLEGI", "length": 336, "molWeight": 38972, "crc64": "18D9F149065F1C52", "md5": "18B86BE712B81E2FC72D4A5212F6687A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 5}, "uniParcId": "UPI0030931111"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96USG5", "uniProtkbId": "A0AA96USG5_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29082.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29082.1"}], "value": "CREWS-C2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 189, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041687059"}, {"type": "Domain", "location": {"start": {"value": 41, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00092"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29082.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651419", "properties": [{"key": "ProteinId", "value": "WNX29082.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVLLHLFLLFVILCSNATPSAAQLVWTCETEIDITFLVHEGDDLDNFVTGLKRYFGYKTDTISFTDNDYSKAVAKLQKQMSRKSSATVVFITSTYSSELELALQMEKAAWDEEILLFAVGMGDESATEWLRALVPDNTENFVFTGTKDALFDKQRQIAQQICEDGKAVIEEGEEPAEDGQIPLDVLENV", "length": 189, "molWeight": 21161, "crc64": "7AB9AB84BD20D00C", "md5": "4083CED643A60D47B5C4FA9DF03BB321"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B31ADDE"}, "cluster_size": 1, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1C9", "uniProtkbId": "A0AAU7P1C9_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30752.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30752.1"}], "value": "Low density lipoprotein receptor"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30752.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 38, "modifier": "EXACT"}, "end": {"value": 38, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30752.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30752.1"}], "id": "KW-0449", "category": "PTM", "name": "Lipoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30752.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30751.1"}], "value": "15", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30752.1"}], "value": "16", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30753.1"}], "value": "17", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30752.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892407", "properties": [{"key": "ProteinId", "value": "XBS30751.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "EMBL", "id": "PP892408", "properties": [{"key": "ProteinId", "value": "XBS30752.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "EMBL", "id": "PP892409", "properties": [{"key": "ProteinId", "value": "XBS30753.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd00112", "properties": [{"key": "EntryName", "value": "LDLa"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "4.10.400.10", "properties": [{"key": "EntryName", "value": "Low-density Lipoprotein Receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036055", "properties": [{"key": "EntryName", "value": "LDL_receptor-like_sf"}]}, {"database": "InterPro", "id": "IPR002172", "properties": [{"key": "EntryName", "value": "LDrepeatLR_classA_rpt"}]}, {"database": "Pfam", "id": "PF00057", "properties": [{"key": "EntryName", "value": "Ldl_recept_a"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57424", "properties": [{"key": "EntryName", "value": "LDL receptor-like module"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "SVSGGQMQYEFQCQEGKCISYKWVCDGSAVPGWLYVPG", "length": 38, "molWeight": 4189, "crc64": "86AB1644C2E7EA0B", "md5": "E533273D80D9A68995651B5DF24A153D"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D3A5B6"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAG2UX05", "uniProtkbId": "A0AAG2UX05_HUMAN", "entryAudit": {"firstPublicDate": "2024-07-24", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-07-24", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518512.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518512.1"}], "value": "PIN2 (TERF1) interacting telomerase inhibitor 1"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518512.1"}], "value": "PINX1"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518512.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAG2UX05"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAG2UX05"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518512.1"}]}], "uniProtKBCrossReferences": [{"database": "PeptideAtlas", "id": "A0AAG2UX05", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000710834.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518512.1"}, {"key": "GeneId", "value": "ENSG00000284764.2"}]}, {"database": "HGNC", "id": "HGNC:30046", "properties": [{"key": "GeneName", "value": "PINX1"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Unplaced"}]}], "sequence": {"value": "XYEIHKRKNSLTEKHHVVFLGKDLSSRSKTDLDCIFGKRQSKKTPEFIVEVTLDSLSYRISHVLNFVDFTFPVGFNVFTS", "length": 80, "molWeight": 9291, "crc64": "3477D10261F85219", "md5": "DC742F45BDB5E14964C855A3119DE25D"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0026457021"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MNU2", "uniProtkbId": "A0AA96MNU2_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50065.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50065.1"}], "value": "Tudor domain-containing protein-like protein"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 160, "modifier": "EXACT"}, "end": {"value": 219, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 349, "modifier": "EXACT"}, "end": {"value": 409, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 557, "modifier": "EXACT"}, "end": {"value": 616, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 746, "modifier": "EXACT"}, "end": {"value": 804, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 949, "modifier": "EXACT"}, "end": {"value": 1008, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1124, "modifier": "EXACT"}, "end": {"value": 1184, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1341, "modifier": "EXACT"}, "end": {"value": 1403, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1590, "modifier": "EXACT"}, "end": {"value": 1649, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1801, "modifier": "EXACT"}, "end": {"value": 1863, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1997, "modifier": "EXACT"}, "end": {"value": 2053, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 2210, "modifier": "EXACT"}, "end": {"value": 2267, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 2451, "modifier": "EXACT"}, "end": {"value": 2520, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 2685, "modifier": "EXACT"}, "end": {"value": 2745, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 4100, "modifier": "EXACT"}, "end": {"value": 4161, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Region", "location": {"start": {"value": 2339, "modifier": "EXACT"}, "end": {"value": 2396, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 2890, "modifier": "EXACT"}, "end": {"value": 2945, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 3174, "modifier": "EXACT"}, "end": {"value": 3451, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 3676, "modifier": "EXACT"}, "end": {"value": 3752, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 3851, "modifier": "EXACT"}, "end": {"value": 3908, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 3934, "modifier": "EXACT"}, "end": {"value": 3981, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 4001, "modifier": "EXACT"}, "end": {"value": 4035, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 2339, "modifier": "EXACT"}, "end": {"value": 2377, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 2890, "modifier": "EXACT"}, "end": {"value": 2904, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 2911, "modifier": "EXACT"}, "end": {"value": 2922, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 2923, "modifier": "EXACT"}, "end": {"value": 2934, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3179, "modifier": "EXACT"}, "end": {"value": 3210, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3211, "modifier": "EXACT"}, "end": {"value": 3236, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3244, "modifier": "EXACT"}, "end": {"value": 3265, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3273, "modifier": "EXACT"}, "end": {"value": 3294, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3302, "modifier": "EXACT"}, "end": {"value": 3323, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3331, "modifier": "EXACT"}, "end": {"value": 3350, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3362, "modifier": "EXACT"}, "end": {"value": 3372, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3373, "modifier": "EXACT"}, "end": {"value": 3388, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3408, "modifier": "EXACT"}, "end": {"value": 3432, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 3881, "modifier": "EXACT"}, "end": {"value": 3908, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 4014, "modifier": "EXACT"}, "end": {"value": 4027, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50065.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460142", "properties": [{"key": "ProteinId", "value": "WNS50065.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd20379", "properties": [{"key": "EntryName", "value": "Tudor_dTUD-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "2.30.30.140:FF:000018", "properties": [{"key": "EntryName", "value": "Serine/threonine-protein kinase 31"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "16"}]}, {"database": "Gene3D", "id": "2.40.50.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "12"}]}, {"database": "InterPro", "id": "IPR035437", "properties": [{"key": "EntryName", "value": "SNase_OB-fold_sf"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR050621", "properties": [{"key": "EntryName", "value": "Tudor_domain_containing"}]}, {"database": "PANTHER", "id": "PTHR22948:SF29", "properties": [{"key": "EntryName", "value": "FI02030P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22948", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "16"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "16"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "16"}]}, {"database": "PROSITE", "id": "PS50304", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "14"}]}], "sequence": {"value": "MEFSDKNVLDVHEDGHLVLALPETPQAQRTVCILGDFVPTEGKWTAQTVNLLKSLVLNKTVSGTMFQTQNSSHQPMVIIFTDSTRTEYISSTLCKAGCGQIRFLPPFATLGEEAAAFTSFVLDRSSFWLQREDSTILSFQEEMDEVYSKPSALSPLPSSSVYEGVACVAVHSETGCFCRAEIVRVPSPGAVEVLFVDYGDRHTYPPANLYAVLPPFALLEAQAIHCQTGEPNNSESSPKFSDFVANQRLLTKFAQVEPATDCRSNVVWFVTVKNTATNEVWSDKVPSVAGGAFGRVSLQIGSTHTVYVSYCDSPDSIWLQLKDGSSNLDRIATDISSMLDRSALLEIASPAVGTRCCAVSALDGIWYRGEIIVMDSDYPTATVQFVDYGNQEVVSCDQITSLPDDLASISAQAIKVALSGVKPCGLLKGWDQETTLRLQDLVTEKELLCKVVATDTSSGKPLVKLTYEQNGVINVASELAKRNLCCYVDFEAKGHGDPIQSLVPVLKAPADVFISSLTSAVEFWVQLAENWSKLTDLDSAMTAHYATPARALLSPDQLKVGTLCAAQFSLDGAWYRAEITSLSQQQEAVVRFFDFGNSESKRASELFVLSPSFADLPKQAVLCVLAGLETSTSSPETATSRLQKYLDVQLVGVFERCTPGGAYHVRLIDTAGGREVHLSSTAPDTAEVAAATVSMPTTGAPFESRITYVESPTEFYAQFTKWESDLNSQLEDMYEHYTSTECGSGNVRENSVCAALFEEDSNWYRARVLSISKTKARVFFVDYGNKVEVDLANLRALNVKFTSLPHQALLCSLDSKNKVLLPNAKETIELATADKVVLVTPTGKMQGPAHLVNVRIGTTDLCSEVMTVALDSASPQGTLKPVSSQSTGKRKLQFSDLRSNSVHKLFLIVWESDSAVACQFADSHLELEVLSGGLNSYYSTKTNLSPPPSISSGDFVCAKFPEDDCWYRALVKKSCHGDQFEVLYLDFGNQATVSKHHIRELDEQFCTTLVQTIVCCFSSPVQSQLSDREDMEVRVLKQIDQLRYSVELAPHTGSVKASVPSLAAPTIIPLALSSVRESGFIDIQVTFAASPMLFYCQDQSCTAHLEKLVEQLNHHCMQLPPRQQPKVSDICVAKFTQDGSWYRARIQSVDLKQGLVGVQFVDYGNADTVPTAHVCDLPLDFSYLPQQAIPCMLSGVFKPTEGWSQSALDIFENLVVEKSFVAEIKGKNSMEGSDQSILVVELLDDDVLLKETFLREVEGFVSRDSQAAGSKDHAPVSLMPYPLLDLETGRTLQAEVTHVESPSSFYLQPFSTEEDLCRVNERIGQAVSDASRSTARLPAGDLSSGAPCLVQFSVDQQWYRGLVERKTEKAGQQSWRVRFVDFGNTEVFTSPSSLLPCPADLLAIPALSLQCALHGVDPMLGVKGWSRLVVTSFTEMLLNKEVEFSILRQDALLAQIKLSLDGRDVRDSFVRSDLVGVLPDIDIVVEAKAPSEDLYLSTASSQVDTNSPAIPSSRQSSDCGDVAMATQSLATAFTYPPPPSNGCKLNVIVSHAESPISFYCQDLKGIDAFSVFGDQLSAYCSSCQPGIQGPLLPGQPCAAKYSLNEEWYRAEVLEITSKDKVLVQFVDFGNSETVSFSELVSLQSEHFSIPTQAFWCSITADFTQQYSDSETERFVSMVSDNEFELTVQSSDEGSLVVSLVDEKGDNVNPTVSKSNTTPVGSGPRVYTSAKVDSAETGPEQALQYTYPAPPAKGTSLKVTVAHVSSPLDFYCQRVETAEDLDKVMNDLDTFCRSGQPKRSPRLEVGLPVGAVYSGDEYWYRAEVVEASSGGAAGDVLVQYIDYGNTELVKSATLLSLPPSLLALPVQGLWCSLSGDFTCEHSEAEVEQFKGICGAGTEFTMLVKSVEQDSLIVSLCDSHGKEIVLSGKPSPSQVEAQQDICFSYPSPLTTGTKMAVEVTHVVSPVDFYCVPESELASLSSLTEELFDCAQEMTSKSLSPQVGSPCASIYEGDWYRCEVTSAQDDQFTVQFVDYGNSQTVGGGEVFPLSQRHVAMAAKAYWCSITSDMDRVFSESEIDEFRNQIEYQTFEMEVCFSEDNSAVVKLQDSNGKEVSLAESVSEKVETGTAKPIEAPTTALQPVHPDAARSSDVGFVSLEPPTAGVPVRVFVTHAVSPVDFYCQLTSSTAELDSLLAELADCCSGSGGPDGGERQWAEGTPCAALSSDGTWYRAEVSETRAETATVFFVDYGNSESDIPLSNLRLLLPAHLALATQALWCSVSYNFEFSFSQSDCASFVQSVTEQEFIMKVLSSEGDSLVVELLEAESGAVLFQDLCQPLTDSSREETVKISEDLPKAAEKEQGAGKEDRGIRLKDLLKPLEGEEEGEADEQALSSKAYPTRQMPAVGSRIQVEVTQVDSPASVYCQDLACSGTFEQLQKDLQAHCTAAQLAPLETVTVGQPCIVSSTVQSLWCRGEVAQELEEEDSEEDGDKNSLVEVFLVDFGQTELVPRSKLMALPENFISRPSFALWCSLTLNFDCKFGEDDIEQFSVILTNQVFELTVLSVMGETLVVSIRDEEGYQVGTKFSDSRKRVAEEDDDDEGNIDADLPNLIATERGYAMRGVDFTTAPIVFKWPLKANIGDKVEVYVSIVESASSFYGQPLHLSEELDQMMNLVGEKLEGLPPISLDRVSVGVVCGARITLDDSWYRAVIEDVGEGVEEVRVRYIDYGNTERLPVQRLVELPAELLNYQSQIFHFSCLSPEEIASLAQAATCDDPDGDVEAVFKDLVAIGGNYQATIRKEISRGKYYVSLFDESGSKVQVPHVALRQEEAAIVSREKEDVVLKDEDQLQGEDGGIKEDITDAEVESITCRISVEELLTKGIVEEALDVAQIVQEEKSDSSIDQHHDPPIPVPHLGDKGEMGQEDHDSNDDEEDDDESSSGSDRSSPPVVPFKLSFGVKEILKVKVSAVESPSVMYLQRSDCQTELRTLIVDIQQYTLTTRGTESREGAFYTSSSPPSVGEFVLAKAEDGEEWRRGEVTRGYSPQANTCTVYFIDHGTTRDTPLPCVQFCPKMLLMLPQQAIMCCLADVPRREAWPDEYTRLIRPHINEGGEGLLQAEVVLPSVEGMRPFVRLINLATKVDLSNVILEQLDKECDEGGFHGSDELGYSPDITKEEQEVCLSEDNDREREDKPDADPDVDELKPTAKEEEVKGEEAVEEEKEESEDENEGSDVVEQEDEQFLAERKESEEEESEGDKEESEVVEQEDEQFLAERKESEEEESEGDKEESEVVEQEDEQFLADRKESEEEESEGDREESEVVEQEDEQFLAERKESEEEESEGDREESEVVEQEDEQFLREKEDDDKLPEVQKDKTEEAVEESGDENQESDVVEEGDKGLLEEQDGEQPGLEKEEGEQENNEEDEFYDTQEDLTEEESGSGSGDVVGYDPSEYTTSLPPRAVLEPEATVSVRLSSADAPTALFCHPTDQAGKLDSAMEKLNSFYNGLNPFDFNLQEEPKAGEIVCIRTWEEEGDDDDDSCTWYRASVVEISYDVDNDDDDDCRDGSPVVTVECVDYGTVEAGGLADVRKLAVEFGGDPPLGLQCGLSGVQSPSGDGLFSEACVDYLNTFVDVEEVLSLRVLQVLKDNKYEVVMTTKGGRLVNQALIDAGFCIATKGSMVTTPISPPKKQSIEVESGSPIGSTLSPPPKETVSAETSSVDDTIPLPAEGLLPENSSHTDSNAEAGESVSDSPLNHPDLSTVDGAQEEVQKCGVSPKGDDKSAVSCESLVGRVLKLDSSSFDVISTPSESAIPVAMDQSFLDNTLQDDKPDEEVGKNPSVQFTQAEAEEQTDALVDTAKSVPLPSRDEEELSSFSSPSKESTKPETDSEQLQSPSTQPDILSCQPNNGKANSETFSKKPTASNFLIAHTAASIEGLLSNAVSPPRPLGHSRSLHTSPTATPMVQPGMGRSISVSSSPRHTRMVPGQSSAMSLASPPFMSVGVSSFDPSSTQSFGQMMPLPPSSSSSSSSSAGSSSHMLSPAHSQGFTDTCPSMMFNPGERLDLVLVKSDSPDNFVCQPNASQKLLRLLMEEMAQFVRVNERVPSPTVEELSGGHCFLCQNHEDKLWYRAEVISVDPSTNSVQVFLLDAGSVIQAGLHDLQPLPLRFSALNRQAVLCSLAHVGPVDTPGEWGPEVVDRLAALLAALPSIAACVVEVIADRPNAVSLQVETDSGTDLADQLVEEGLAAPRLSKL", "length": 4244, "molWeight": 463316, "crc64": "73F7E9E6ED84CCE4", "md5": "0D0E221CD4EB11C6FFF08011832134AA"}, "extraAttributes": {"countByFeatureType": {"Domain": 14, "Region": 7, "Compositional bias": 15}, "uniParcId": "UPI002B303B83"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7A8", "uniProtkbId": "A0AAN0N7A8_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34090.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34090.1"}], "value": "Muscrinic acethylcholine receptor-like GPCR protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 255, "modifier": "EXACT"}, "end": {"value": 283, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 295, "modifier": "EXACT"}, "end": {"value": 321, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 333, "modifier": "EXACT"}, "end": {"value": 354, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 375, "modifier": "EXACT"}, "end": {"value": 400, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 420, "modifier": "EXACT"}, "end": {"value": 443, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 734, "modifier": "EXACT"}, "end": {"value": 754, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 774, "modifier": "EXACT"}, "end": {"value": 795, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 275, "modifier": "EXACT"}, "end": {"value": 792, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34090.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155016", "properties": [{"key": "ProteinId", "value": "WRW34090.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0030425", "properties": [{"key": "GoTerm", "value": "C:dendrite"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0045202", "properties": [{"key": "GoTerm", "value": "C:synapse"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016907", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled acetylcholine receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004993", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled serotonin receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007197", "properties": [{"key": "GoTerm", "value": "P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007187", "properties": [{"key": "GoTerm", "value": "P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd15049", "properties": [{"key": "EntryName", "value": "7tmA_mAChR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR000995", "properties": [{"key": "EntryName", "value": "Musac_Ach_rcpt"}]}, {"database": "PANTHER", "id": "PTHR24247", "properties": [{"key": "EntryName", "value": "5-HYDROXYTRYPTAMINE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24247:SF265", "properties": [{"key": "EntryName", "value": "MUSCARINIC ACETYLCHOLINE RECEPTOR DM1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "PRINTS", "id": "PR00243", "properties": [{"key": "EntryName", "value": "MUSCARINICR"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MALQFFTSLPTTSYFLQNPINCFLKFKNERLNNTSLNENFIFASINSTQKLNSFLSESKILPSYNQNSDDSCEKLINLFEKRRIKKRKKRKIVKKATSLKSNQRSNISLIKNINLNKKIEKRSINFNSSIYTSNYSNIGHKNNFGENFLEIVQLPKKITTYLEKRQNNVYKSLKQNFSKNIKEYIHKDNITSLNTDNKKEDNFRINLKNSLDNLENDIQLNESSSIDSSHFVNNSNKDFVNSKDDFKTKLPKINIFYFVLFTVLAVFLSLITIIGNMLVMISLVIDRQLRTISNYFLLSLSIADFLIGLISMPLYTIYLLLGKWPLGPIVCDAWLALDYLNCNASIFNLLVISFDRYYSVTRPLTYRVQRTKKRAFIIIAFTWIISLLLWDPWIYLWPYIEGKRTVPDDDCYVQFLKSNPYITFVTAIAAFYLPVTVMIILYFRIWRETQQRYKDITTLFLVSTAGGKVIKSKNKSKIDSNTIDNTNKISKCQMLNLNEELKDVSNKEKNNEINKLNQKKPISFWRKFCTFNESIQSQSTIVNKSSEKKEETNSKNFLTIDYSSYSIDKNQDNEKTDDIENQELRCHADNEDLENEKKISTENKTSTDSIYTILIKLHQVDSETGPSIKMLESQVNSSEKSNNTKIKENLQQSDTNNNQHNETEPLTIANGLKKENFYNNIMKIDSTLDAESVTSGSVLKNIYPTQQTSSIRNTTIGINTPLQPKSERKAAKTLSAILLAFIFTWTPYNVVALLNSLLVNKDNLEEDFIPKPIWLFSYYLCYINSTVNPLCYALCNASFRRTYIRILKCKWTKSKRSAAASQRYLNEKRHLNESKTKYRHWMT", "length": 843, "molWeight": 98005, "crc64": "71BFDA67F5485EF1", "md5": "0819728326C076C35B941D737AE13D0D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI00324E9C06"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9T4U2", "uniProtkbId": "A0AAT9T4U2_ACIBE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Acipenser baerii", "commonName": "Siberian sturgeon", "taxonId": 27689, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WCC87491.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Chondrostei", "Acipenseriformes", "Acipenseridae", "Acipenser"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WCC87491.1"}], "value": "Trkb"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 31, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 32, "modifier": "EXACT"}, "end": {"value": 367, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043669783"}, {"type": "Domain", "location": {"start": {"value": 197, "modifier": "EXACT"}, "end": {"value": 283, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023319"}], "id": "KW-0393", "category": "Domain", "name": "Immunoglobulin domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022614"}], "id": "KW-0433", "category": "Domain", "name": "Leucine-rich repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4PGA8C8JNDFPE", "citationType": "submission", "authors": ["Zhang S."], "publicationDate": "JAN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WCC87491.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ332353", "properties": [{"key": "ProteinId", "value": "WCC87491.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005030", "properties": [{"key": "GoTerm", "value": "F:neurotrophin receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004714", "properties": [{"key": "GoTerm", "value": "F:transmembrane receptor protein tyrosine kinase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007169", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor protein tyrosine kinase signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "2.60.40.10:FF:000032", "properties": [{"key": "EntryName", "value": "palladin isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.80.10.10:FF:000163", "properties": [{"key": "EntryName", "value": "Tyrosine-protein kinase receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.80.10.10", "properties": [{"key": "EntryName", "value": "Ribonuclease Inhibitor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000483", "properties": [{"key": "EntryName", "value": "Cys-rich_flank_reg_C"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR013098", "properties": [{"key": "EntryName", "value": "Ig_I-set"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR001611", "properties": [{"key": "EntryName", "value": "Leu-rich_rpt"}]}, {"database": "InterPro", "id": "IPR032675", "properties": [{"key": "EntryName", "value": "LRR_dom_sf"}]}, {"database": "InterPro", "id": "IPR020777", "properties": [{"key": "EntryName", "value": "NTRK"}]}, {"database": "InterPro", "id": "IPR020455", "properties": [{"key": "EntryName", "value": "NTRK2"}]}, {"database": "InterPro", "id": "IPR031635", "properties": [{"key": "EntryName", "value": "NTRK_LRRCT"}]}, {"database": "PANTHER", "id": "PTHR24366", "properties": [{"key": "EntryName", "value": "IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24366:SF170", "properties": [{"key": "EntryName", "value": "RE50361P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07679", "properties": [{"key": "EntryName", "value": "I-set"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13855", "properties": [{"key": "EntryName", "value": "LRR_8"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF16920", "properties": [{"key": "EntryName", "value": "LRRCT_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01939", "properties": [{"key": "EntryName", "value": "NTKRECEPTOR"}]}, {"database": "PRINTS", "id": "PR01941", "properties": [{"key": "EntryName", "value": "NTKRECEPTOR2"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00082", "properties": [{"key": "EntryName", "value": "LRRCT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF52058", "properties": [{"key": "EntryName", "value": "L domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MITFWRCHGAAVMSLWVFCWLLLGLWRLTVACPSSCTCSSSRISCIEQDQGIVAFPVLSSAIEMENITEIYIANQSQLRAINDIDVETYLGLRNLTVTNSGLSYVSRRSFQKTPNLQYVNLKNNKLSTLSWKTFRNLNLAYLVLTGNPFQCSCDIQWIKLWQENEMASLETQNLMCKDDSNRKFLLHEMHIPDCVMPTSSISPSSVTLMEGSDITLECRTSGIPSPDVSWYLGNLVTSYQQYNVKQHYTTLKMINVSSNDTGKTVLCIAENIVGENESSVILVVHFPPKITFLDQAVLDHHWCIPFSVRGNPKPKLIWFYEGAVLNETDFIWTSIHIAFDSEHHGCLQLDSPTHLNNGQYTLLAKNE", "length": 367, "molWeight": 41607, "crc64": "4FA280C55C36AD37", "md5": "2DE01A7FCF3ED397E6B265BC813CC746"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI0035D338C9"}, "cluster_size": 1, "family": "Acipenseridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96ZPA2", "uniProtkbId": "A0AA96ZPA2_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29090.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29090.1"}], "value": "VWACP-7"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 421, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041742093"}, {"type": "Domain", "location": {"start": {"value": 39, "modifier": "EXACT"}, "end": {"value": 215, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29090.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651427", "properties": [{"key": "ProteinId", "value": "WNX29090.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00453", "properties": [{"key": "EntryName", "value": "VWFADOMAIN"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFACILMMVITLGISAGEPPVGDSMDDEILKECQNQQSDIYFLLDSSSSQSLSDFQKLKDFVVSFVKQLDIGPNTTRVGLGLFASDFFAQFDLGQHSNKNAVIQAVQGVNFTGGGTYTSRGLRGMRTSGFEDGVVRKKATKIGVVVTDGRTRHRTDTLAEASELEDMGVWLFAIGVGSRVDERELSIFSSEPHREFLRYVPTFDDLAAPDLLSHLASSACNLQPPHADNAMCGGDQKADILFVYNAVAMTPSNLSDVQAFTVNLIRNFSMTSGKVRVGLVSEGRQGGDIALSQYIRKEDIVWALKHQRRSEIAELLRKVRQQGYKAHFGGRTNAKKFAIIFMNDADITIDAMVEAQIMTYNDVIVYVIEVGLDLPESGFNKYPWLRSRLGHVLKFASYAELLNPTGREEREKFIKKLCRYM", "length": 421, "molWeight": 46817, "crc64": "87A8C88FD90B7E93", "md5": "7AFD3C3790BFF9B59F35A5F69FDBEDFE"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B284B32"}, "cluster_size": 2, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHK1", "uniProtkbId": "A0AAQ5BHK1_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519415.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519415.1"}], "value": "Transmembrane protein 181"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519415.1"}], "value": "TMEM181"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHK1"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519415.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "14574404", "citationType": "journal article", "authors": ["Mungall A.J.", "Palmer S.A.", "Sims S.K.", "Edwards C.A.", "Ashurst J.L.", "Wilming L.", "Jones M.C.", "Horton R.", "Hunt S.E.", "Scott C.E.", "Gilbert J.G.", "Clamp M.E.", "Bethel G.", "Milne S.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Andrews T.D.", "Ashwell R.I.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beare D.M.", "Beasley H.", "Beasley O.", "Bird C.P.", "Blakey S.", "Bray-Allen S.", "Brook J.", "Brown A.J.", "Brown J.Y.", "Burford D.C.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Clark S.Y.", "Clark G.", "Clee C.M.", "Clegg S.", "Cobley V.", "Collier R.E.", "Collins J.E.", "Colman L.K.", "Corby N.R.", "Coville G.J.", "Culley K.M.", "Dhami P.", "Davies J.", "Dunn M.", "Earthrowl M.E.", "Ellington A.E.", "Evans K.A.", "Faulkner L.", "Francis M.D.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Ghori M.J.", "Gilby L.M.", "Gillson C.J.", "Glithero R.J.", "Grafham D.V.", "Grant M.", "Gribble S.", "Griffiths C.", "Griffiths M.", "Hall R.", "Halls K.S.", "Hammond S.", "Harley J.L.", "Hart E.A.", "Heath P.D.", "Heathcott R.", "Holmes S.J.", "Howden P.J.", "Howe K.L.", "Howell G.R.", "Huckle E.", "Humphray S.J.", "Humphries M.D.", "Hunt A.R.", "Johnson C.M.", "Joy A.A.", "Kay M.", "Keenan S.J.", "Kimberley A.M.", "King A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.R.", "Lloyd D.M.", "Loveland J.E.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Maslen G.L.", "Matthews L.", "McCann O.T.", "McLaren S.J.", "McLay K.", "McMurray A.", "Moore M.J.", "Mullikin J.C.", "Niblett D.", "Nickerson T.", "Novik K.L.", "Oliver K.", "Overton-Larty E.K.", "Parker A.", "Patel R.", "Pearce A.V.", "Peck A.I.", "Phillimore B.", "Phillips S.", "Plumb R.W.", "Porter K.M.", "Ramsey Y.", "Ranby S.A.", "Rice C.M.", "Ross M.T.", "Searle S.M.", "Sehra H.K.", "Sheridan E.", "Skuce C.D.", "Smith S.", "Smith M.", "Spraggon L.", "Squares S.L.", "Steward C.A.", "Sycamore N.", "Tamlyn-Hall G.", "Tester J.", "Theaker A.J.", "Thomas D.W.", "Thorpe A.", "Tracey A.", "Tromans A.", "Tubby B.", "Wall M.", "Wallis J.M.", "West A.P.", "White S.S.", "Whitehead S.L.", "Whittaker H.", "Wild A.", "Willey D.J.", "Wilmer T.E.", "Wood J.M.", "Wray P.W.", "Wyatt J.C.", "Young L.", "Younger R.M.", "Bentley D.R.", "Coulson A.", "Durbin R.", "Hubbard T.", "Sulston J.E.", "Dunham I.", "Rogers J.", "Beck S."], "citationCrossReferences": [{"database": "PubMed", "id": "14574404"}, {"database": "DOI", "id": "10.1038/nature02055"}], "title": "The DNA sequence and analysis of human chromosome 6.", "publicationDate": "2003", "journal": "Nature", "firstPage": "805", "lastPage": "811", "volume": "425"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519415.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519415.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519415.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL591025", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000714113.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519405.1"}, {"key": "GeneId", "value": "ENSG00000146433.12"}]}, {"database": "Ensembl", "id": "ENST00000714124.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519415.1"}, {"key": "GeneId", "value": "ENSG00000146433.12"}]}, {"database": "Ensembl", "id": "ENST00000714194.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519483.1"}, {"key": "GeneId", "value": "ENSG00000146433.12"}]}, {"database": "HGNC", "id": "HGNC:20958", "properties": [{"key": "GeneName", "value": "TMEM181"}]}, {"database": "OpenTargets", "id": "ENSG00000146433", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000007183", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 6"}]}], "sequence": {"value": "MDAEYPAFEPPLCSELKHLCRRLREAYRELKEDLTPFKDDRYYRPVTKR", "length": 49, "molWeight": 6047, "crc64": "891C8CF3AD30243A", "md5": "657F31E8CCC703BA82296D1108BBCF88"}, "extraAttributes": {"uniParcId": "UPI0032CA4859"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFE7", "uniProtkbId": "A0AAU7VFE7_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67481.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67481.1"}], "value": "Boule1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67481.1"}], "value": "boule1"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 115, "modifier": "EXACT"}}, "description": "RRM", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50102"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022782"}], "id": "KW-0221", "category": "Biological process", "name": "Differentiation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00176"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022871"}], "id": "KW-0744", "category": "Biological process", "name": "Spermatogenesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022845"}], "id": "KW-0810", "category": "Biological process", "name": "Translation regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67481.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67481.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750686", "properties": [{"key": "ProteinId", "value": "XBW67481.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003730", "properties": [{"key": "GoTerm", "value": "F:mRNA 3'-UTR binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008494", "properties": [{"key": "GoTerm", "value": "F:translation activator activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0070935", "properties": [{"key": "GoTerm", "value": "P:3'-UTR-mediated mRNA stabilization"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030154", "properties": [{"key": "GoTerm", "value": "P:cell differentiation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0051321", "properties": [{"key": "GoTerm", "value": "P:meiotic cell cycle"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0045948", "properties": [{"key": "GoTerm", "value": "P:positive regulation of translational initiation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007283", "properties": [{"key": "GoTerm", "value": "P:spermatogenesis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd12412", "properties": [{"key": "EntryName", "value": "RRM_DAZL_BOULE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.70.330:FF:000167", "properties": [{"key": "EntryName", "value": "protein boule-like isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.70.330", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR034988", "properties": [{"key": "EntryName", "value": "DAZ_BOULE_RRM"}]}, {"database": "InterPro", "id": "IPR012677", "properties": [{"key": "EntryName", "value": "Nucleotide-bd_a/b_plait_sf"}]}, {"database": "InterPro", "id": "IPR035979", "properties": [{"key": "EntryName", "value": "RBD_domain_sf"}]}, {"database": "InterPro", "id": "IPR000504", "properties": [{"key": "EntryName", "value": "RRM_dom"}]}, {"database": "PANTHER", "id": "PTHR11176", "properties": [{"key": "EntryName", "value": "BOULE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11176:SF57", "properties": [{"key": "EntryName", "value": "PROTEIN BOULE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00076", "properties": [{"key": "EntryName", "value": "RRM_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00360", "properties": [{"key": "EntryName", "value": "RRM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54928", "properties": [{"key": "EntryName", "value": "RNA-binding domain, RBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50102", "properties": [{"key": "EntryName", "value": "RRM"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDGSLVFSPYNNAMAGGSGTGYLNSMHIPKFGTLVPNRIFVGGIASDTTESELKNFFSSFGNVRDCKIILDRGGLSKSYGFVTFESPEDAEKIIKRSADTLIMRDRKLNIGPAIRKQSMQGERLYGGGDLSPSTSMSACSVGGGMGGAGALMYPNALSYAATLGNGVTLMCTSDGYLIPTQTPQAAMYPSVIYHSPAGYYQSPMAATTPSAAAPPAPQWTTSPQWRYPSIQAPGGSLVASPCGQYLYQIPNSMQSSGGAPIMGSDMLIAQSTAGPSQYQTNANHGSCDDQ", "length": 290, "molWeight": 30414, "crc64": "3A4245AC97248C9C", "md5": "4DE10055DF6760D4F1D2F9BC37CC8D2D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D2E107"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA95ZAN0", "uniProtkbId": "A0AA95ZAN0_PSIGU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Psidium guajava", "commonName": "Guava", "synonyms": ["Psidium pyriferum"], "taxonId": 120290, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01970.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "malvids", "Myrtales", "Myrtaceae", "Myrtoideae", "Myrteae", "Pimenta group", "Psidium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01970.1"}], "value": "Terpene synthase"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 31, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "Terpene synthase N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01397"}]}, {"type": "Domain", "location": {"start": {"value": 125, "modifier": "EXACT"}, "end": {"value": 192, "modifier": "EXACT"}}, "description": "Terpene synthase metal-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF03936"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022842"}], "id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FCTKIOK6O0LM0", "citationType": "submission", "authors": ["Canal D.", "dos Santos P.H.D.", "Carpinetti-Oliveira P.A.", "Silva M.A.", "Fernandes M.", "Brustolini O.J.B.", "Ferreira A.", "Ferreira M.F.S."], "title": "Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01970.1"}], "value": "Pg55462", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01970.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR232578", "properties": [{"key": "ProteinId", "value": "WNI01970.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0000287", "properties": [{"key": "GoTerm", "value": "F:magnesium ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0010333", "properties": [{"key": "GoTerm", "value": "F:terpene synthase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016114", "properties": [{"key": "GoTerm", "value": "P:terpenoid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.600.10", "properties": [{"key": "EntryName", "value": "Farnesyl Diphosphate Synthase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.50.10.130", "properties": [{"key": "EntryName", "value": "Terpene synthase, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008949", "properties": [{"key": "EntryName", "value": "Isoprenoid_synthase_dom_sf"}]}, {"database": "InterPro", "id": "IPR001906", "properties": [{"key": "EntryName", "value": "Terpene_synth_N"}]}, {"database": "InterPro", "id": "IPR036965", "properties": [{"key": "EntryName", "value": "Terpene_synth_N_sf"}]}, {"database": "InterPro", "id": "IPR050148", "properties": [{"key": "EntryName", "value": "Terpene_synthase-like"}]}, {"database": "InterPro", "id": "IPR005630", "properties": [{"key": "EntryName", "value": "Terpene_synthase_metal-bd"}]}, {"database": "InterPro", "id": "IPR008930", "properties": [{"key": "EntryName", "value": "Terpenoid_cyclase/PrenylTrfase"}]}, {"database": "PANTHER", "id": "PTHR31225", "properties": [{"key": "EntryName", "value": "OS04G0344100 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31225:SF241", "properties": [{"key": "EntryName", "value": "TERPENE SYNTHASE FAMILY, METAL-BINDING DOMAIN PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01397", "properties": [{"key": "EntryName", "value": "Terpene_synth"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03936", "properties": [{"key": "EntryName", "value": "Terpene_synth_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48239", "properties": [{"key": "EntryName", "value": "Terpenoid cyclases/Protein prenyltransferases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48576", "properties": [{"key": "EntryName", "value": "Terpenoid synthases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSQVSVIPTSSPSKGTGHTTERQSQKFKFLGRVEGQIEELKGEVRKMLAGIVDKPLQKLHLIDQIQRLGIEYHFEHEIDEGLEQIHKSYSRLYREDFKVDDLHMVALIFRLSTTTRLLRFIGWWKDIDVPRKFPFARDRIVELFFWALGIYFEPEFAVAREILTKVISLTSISMISTTLRPLEELTLLTEAI", "length": 192, "molWeight": 22377, "crc64": "F548436010275F44", "md5": "C8701079EDE2E39F07D73ACFB4052214"}, "extraAttributes": {"countByFeatureType": {"Domain": 2, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B282E27"}, "cluster_size": 1, "family": "Myrtaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MPL8", "uniProtkbId": "A0AA96MPL8_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50064.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50064.1"}], "value": "Serine/threonine-protein kinase STE20-like protein"}}]}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:10596"}, {"database": "Rhea", "id": "RHEA-COMP:10136"}, {"database": "Rhea", "id": "RHEA-COMP:20101"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:46858"}, {"database": "ChEBI", "id": "CHEBI:61978"}, {"database": "ChEBI", "id": "CHEBI:456216"}], "ecNumber": "2.7.10.1", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00051243"}]}}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 414, "modifier": "EXACT"}, "end": {"value": 681, "modifier": "EXACT"}}, "description": "Protein kinase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50011"}]}, {"type": "Region", "location": {"start": {"value": 90, "modifier": "EXACT"}, "end": {"value": 203, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 255, "modifier": "EXACT"}, "end": {"value": 275, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 445, "modifier": "EXACT"}, "end": {"value": 445, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022777"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50064.1"}], "id": "KW-0418", "category": "Molecular function", "name": "Kinase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU10141"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023137"}], "id": "KW-0829", "category": "Molecular function", "name": "Tyrosine-protein kinase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50064.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460141", "properties": [{"key": "ProteinId", "value": "WNS50064.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043235", "properties": [{"key": "GoTerm", "value": "C:receptor complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0004714", "properties": [{"key": "GoTerm", "value": "F:transmembrane receptor protein tyrosine kinase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007169", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor protein tyrosine kinase signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00192", "properties": [{"key": "EntryName", "value": "PTKc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.510.10:FF:000554", "properties": [{"key": "EntryName", "value": "Predicted protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.510.10", "properties": [{"key": "EntryName", "value": "Transferase(Phosphotransferase) domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR011009", "properties": [{"key": "EntryName", "value": "Kinase-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR000719", "properties": [{"key": "EntryName", "value": "Prot_kinase_dom"}]}, {"database": "InterPro", "id": "IPR017441", "properties": [{"key": "EntryName", "value": "Protein_kinase_ATP_BS"}]}, {"database": "InterPro", "id": "IPR050122", "properties": [{"key": "EntryName", "value": "RTK"}]}, {"database": "InterPro", "id": "IPR001245", "properties": [{"key": "EntryName", "value": "Ser-Thr/Tyr_kinase_cat_dom"}]}, {"database": "InterPro", "id": "IPR008266", "properties": [{"key": "EntryName", "value": "Tyr_kinase_AS"}]}, {"database": "InterPro", "id": "IPR020635", "properties": [{"key": "EntryName", "value": "Tyr_kinase_cat_dom"}]}, {"database": "PANTHER", "id": "PTHR24416:SF539", "properties": [{"key": "EntryName", "value": "RECEPTOR PROTEIN-TYROSINE KINASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24416", "properties": [{"key": "EntryName", "value": "TYROSINE-PROTEIN KINASE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07714", "properties": [{"key": "EntryName", "value": "PK_Tyr_Ser-Thr"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00109", "properties": [{"key": "EntryName", "value": "TYRKINASE"}]}, {"database": "SMART", "id": "SM00219", "properties": [{"key": "EntryName", "value": "TyrKc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56112", "properties": [{"key": "EntryName", "value": "Protein kinase-like (PK-like)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00107", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_ATP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50011", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00109", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_TYR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLIPENNDVYFALFIASTSLLALVMVGCSVAWCVCYCRAHKQRRAKRRIKSFRRRVSTENGNVQVGQMQLDLMAVEAEVESAAAQPYEVPLPRAAPPHSNANRSVPPVPNSYADPNSSTSYYEEPAAVERHPNRSPSARKKLDTPKLAHNGTPAPVETDSRRENVATNIMDEANFYDDPNYHEPASVRSKKKHKPPQEKKEKPKLLSVDIVTPPSAAEEQLPRFPLVAEPECSSRVPNELEMYMNVPLRDESILTSSSDGENEDSPTIIREGPLDCSKRDSTLGVLTSTAYQELDVIQVEELEENEDNLYQNVHHRPNMLQIQRSKQEVRSSYINLEDLQEHLTPQQEPQPRRELNPRITSIYITADSLEGLLKDNENEKDAITENLWEPQGNASQIHMEMSLRHYPLLDNFDIEYVQKLGEGEFGEVYKGKRTIQEEIQLVAVKELKTSASEEDRTKLLKEAALMGQFKHKHIVALLGVISQDTEVSLIMEFLEEGDLKKYLAARKMQAATMPHLNKRLLKFCIHIADAMSYLSGRGFIHRDLAARNILLDRNMNCKIADFGMSRDLEGSYYYKSRGGRIPLKWTAPEAILFRKYSTKSDVWSYGMVMYEIWSFGHEPFEDFKVEEVISKFDCGYCQHPPPGCPRPVYHMMVKCWNPDAHQRPKFPEIYATLTSKSQAMLTWSSRDSAEQESTILGSHLHYGSLLYQDLQEKYNL", "length": 716, "molWeight": 81727, "crc64": "99DA926D102DE4B0", "md5": "9D796BB88A60B81CC0E1E10846DF7EF9"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1, "Region": 2, "Binding site": 1}, "uniParcId": "UPI002B2D42BD"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTP1", "uniProtkbId": "A0AAT9UTP1_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41701.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41701.1"}], "value": "Cytochrome P450 4461J1"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003690"}], "value": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides"}], "commentType": "FUNCTION"}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 458, "modifier": "EXACT"}, "end": {"value": 458, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41701.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117261", "properties": [{"key": "ProteinId", "value": "WIM41701.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002403", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-IV"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00465", "properties": [{"key": "EntryName", "value": "EP450IV"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVLLLVVATFVTIFLSIRRVYFRRHQRYYELLKQFPSPPTYPFIGNLKPSHFVSDDFLKTFEELLKSHDRLVYWIGPKPILLLKNFDDISTILHQNSDRNFFGLGNQWFGEGIVTNRYAEWKKSKKLLTPAFSSEMLFKYCDVFNRKSSALVQQLKSFAGSGEEIDIHEYVMNTNVEVILENVMGVSTEKSGKEVKGFGVALEHGIQDVLKRHVSPWLYPHIIYSTYLKLSGRMKFVETLKRLPEEVVKETIIKVNNDTCSTENVDSSKCVVDLLIKARHQDSCFTETRLRDELLQVISTGSETSALNVSFTLLMLAIHQDIQVCNSYRFHNTKNDCYIILQQKVYEEITQLVGEHEEFTSDHLFNHLKYLEQCIRETLRMFNPAASILRQTQKEHVLKDNTIVPADLSIGIVFHLAHRDTALYENPHKWNPENFSTQAIASRPKGSDLNFSIGPRSCIGTKYAILSNKSQIAQIIHNYHLSTSIKELKPEYLKMDISIRSKVGFPIRFTHRKKTRPENI", "length": 520, "molWeight": 60144, "crc64": "B89811ADB86D8F13", "md5": "3368BA8B8C4BF5EEA1FB877D517129CC"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D2D742"}, "cluster_size": 5, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PBF5", "uniProtkbId": "A0AAU6PBF5_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20548.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20548.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20548.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 147, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20548.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20548.1"}], "value": "U_LCTX_66_Cm16", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20548.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480817", "properties": [{"key": "ProteinId", "value": "WXB20548.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd20235", "properties": [{"key": "EntryName", "value": "PFM_spherulin-2a-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.170.15.10", "properties": [{"key": "EntryName", "value": "Proaerolysin, chain A, domain 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56973", "properties": [{"key": "EntryName", "value": "Aerolisin/ETX pore-forming domain"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "LSPIRAKVLGIHSEPVIINTQEFTNNSTDEAKFTAAISQTIEETIANSWSTGGEFTLGQEISYSCEFAGVGVSGSTSMSFSASWGKETSQSKSFTVGSSTGVEVVVKPGKATQISLSATRGTMDAQIDYVARLDGWVACNYEDTYKG", "length": 147, "molWeight": 15596, "crc64": "AA41E15F35533719", "md5": "0F416FB12BB368F4CBB2FD64FE6A04E7"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D3C1EE"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7J941", "uniProtkbId": "A0AAU7J941_LOCMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Locusta migratoria", "commonName": "Migratory locust", "taxonId": 7004, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89715.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Polyneoptera", "Orthoptera", "Caelifera", "Acrididea", "Acridomorpha", "Acridoidea", "Acrididae", "Oedipodinae", "Locusta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89715.1"}], "value": "Tudor domain-containing protein Tdr12"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 102, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00333"}]}, {"type": "Region", "location": {"start": {"value": 324, "modifier": "EXACT"}, "end": {"value": 346, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 402, "modifier": "EXACT"}, "end": {"value": 422, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 509, "modifier": "EXACT"}, "end": {"value": 528, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 330, "modifier": "EXACT"}, "end": {"value": 341, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89715.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3S1R4NEJO2BB6", "citationType": "submission", "authors": ["Deng S.", "Wang J.", "Ma E.", "Zhang J.", "Xing S."], "title": "Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBN89715.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR912214", "properties": [{"key": "ProteinId", "value": "XBN89715.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd20379", "properties": [{"key": "EntryName", "value": "Tudor_dTUD-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "KYGFLCYIRFVLSLINIKCFVYILRARSLKIGICVYKCKCEMASVVPELPSDSIEMCLVELQSPSSMWLVDVINKQISKKFYEVEERLKQVLERGKPQYCNRMLNIGDIVAVYDPVSDAWCRARISDIYQKLAKYIYSVFLVDRGYSITSDPKNIKELPPEASTIQFRCYHIQLYGIIPVSPPNTIASPENVDLQCWLPESITEVKNLLDSCEALYFTPKVARRTVYGDIYLKINCGYIHLTNYLCENNFAVYDSDRFELMMETAPYMSCQQGFSVNSNIENRSITDYITANEVTEEASSFQEENGCANPCRDPEEVPLEHSYENKSLENDSTPSSPSRTKGSQRRISALQRYYEEMREADRRSAGLDRRIFSGGTKETSPKRHFPAIGRGEKLQMLQKLSAGKKPGGGYGSNSTTNETRDKFEDKDTLIDELSNLSVNVTNTVGQYEGKKTKMDSDTYPSYSHTEKQHMIKQTAEQENVPMPNGNIFCRTSKTMFLPAGSEMSMLVAKKKDRNHPDNFTGKEPTLSD", "length": 528, "molWeight": 60144, "crc64": "B66FFE160989C977", "md5": "285D3FED2FC28FB359DB051465E28B65"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 3, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D3449D"}, "cluster_size": 1, "family": "Acrididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QJZ0", "uniProtkbId": "A0AAU0QJZ0_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56512.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 138, "modifier": "EXACT"}, "end": {"value": 158, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 189, "modifier": "EXACT"}, "end": {"value": 216, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 270, "modifier": "EXACT"}, "end": {"value": 289, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56512.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56512.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970405", "properties": [{"key": "ProteinId", "value": "WPO56512.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAPGHTLPSHKTVVFFLNLNKIVYICGLPNIWGDALSISKPIQKFYNIFRHVSNLIFIIFIILEALSYFTQKNLTEKQKSVQAMFVLAHPLLFAYIASVDIWKNKIERLLHELVVELKRIHNDLHVEASMIRKAKKHCASFFSMFMITILMYGFEAIIDVIREGGTFTTVITSWPDVEDRSLLAGLARVFFYFLWWLFMVRVCAMYLEVISTIVVLSHQFKNLQKYFISLNLIFDQDLDQNGKELKYLESFKLGIKMHSKTLWCTKECQAAYNLLFGFQIMSVISILAMQMRQMVANVRTLENIVAVVSATAISLSSTGFLMCNAGDVTVEAADIPTAMYMSGWEKCHIHSISVRQLMIITMVQSQKPVIIRALGKIDFSYSSFVSLIKTSYTVFSVLF", "length": 399, "molWeight": 45695, "crc64": "3DED92528D36C5B1", "md5": "D783F6A5C01AF44901B12A3F09AA4F68"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 5}, "uniParcId": "UPI0030885480"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZE51", "uniProtkbId": "A0AB38ZE51_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71696.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71696.1"}], "value": "Venom nucleosidase 1"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009176"}], "value": "Belongs to the IUNH family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 335, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044197716"}, {"type": "Domain", "location": {"start": {"value": 31, "modifier": "EXACT"}, "end": {"value": 323, "modifier": "EXACT"}}, "description": "Inosine/uridine-preferring nucleoside hydrolase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01156"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023295"}], "id": "KW-0326", "category": "Molecular function", "name": "Glycosidase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71696.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510771", "properties": [{"key": "ProteinId", "value": "WXH71696.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016799", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity, hydrolyzing N-glycosyl compounds"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.90.245.10", "properties": [{"key": "EntryName", "value": "Ribonucleoside hydrolase-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR015910", "properties": [{"key": "EntryName", "value": "I/U_nuclsd_hydro_CS"}]}, {"database": "InterPro", "id": "IPR001910", "properties": [{"key": "EntryName", "value": "Inosine/uridine_hydrolase_dom"}]}, {"database": "InterPro", "id": "IPR052775", "properties": [{"key": "EntryName", "value": "IUN_hydrolase"}]}, {"database": "InterPro", "id": "IPR036452", "properties": [{"key": "EntryName", "value": "Ribo_hydro-like"}]}, {"database": "PANTHER", "id": "PTHR46190:SF1", "properties": [{"key": "EntryName", "value": "SI:CH211-201H21.5"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46190", "properties": [{"key": "EntryName", "value": "SI:CH211-201H21.5-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01156", "properties": [{"key": "EntryName", "value": "IU_nuc_hydro"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53590", "properties": [{"key": "EntryName", "value": "Nucleoside hydrolase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01247", "properties": [{"key": "EntryName", "value": "IUNH"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MARLILVLYCFTLSFILQELNANAIETKRKIIVDADPGSDDAVAILLLLSNPKFSNIKAITTVNGNTNIGNSTRNAIRILEVANRLDIPIYRGAEKGLIYSASSDNFFGVDGFGESKFNTPLPSKEIKNDIPAAMVIVNEVKAHPNEVIILAIGPLTNLAMAIFLYPTLLQEVRQVIILGGSYQGVGISQPGSEFNFYCDPEAVQVVLSNSPVDKPVVILPVETINEIQLPLSWRKREMGKIPTSTIKFLNKVENYTMKGPHWISYDAVAAAILVEPAVIKKSLMVSIETLACPEKARGVILIDYNSKKPNVRLITHLDQQLLKKALLENFSKSV", "length": 335, "molWeight": 36843, "crc64": "19823CD7E39071B2", "md5": "29357B479B69A520C59F94784EE5337A"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388C1DC2"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0UF41", "uniProtkbId": "A0AAU0UF41_ARGRE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Argyrosomus regius", "commonName": "Meagre", "taxonId": 172269, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI00769.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Neoteleostei", "Acanthomorphata", "Eupercaria", "Sciaenidae", "Argyrosomus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI00769.1"}], "value": "T-cell surface glycoprotein CD3 zeta chain"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI00769.1"}], "value": "cd247"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004251"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004251"}], "value": "Single-pass type I membrane protein", "id": "SL-9905"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043546701"}, {"type": "Transmembrane", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 50, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 89, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI00769.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022859"}], "id": "KW-0391", "category": "Biological process", "name": "Immunity"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022553"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4NEO3I2QMT9U", "citationType": "submission", "authors": ["Rocha A."], "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI00769.1"}], "value": "Head kidney", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI00769.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP068270", "properties": [{"key": "ProteinId", "value": "WRI00769.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0032998", "properties": [{"key": "GoTerm", "value": "C:Fc-epsilon receptor I complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0019767", "properties": [{"key": "GoTerm", "value": "F:IgE receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0002376", "properties": [{"key": "GoTerm", "value": "P:immune system process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR021663", "properties": [{"key": "EntryName", "value": "CD3_zeta/IgE_Fc_rcpt_gamma"}]}, {"database": "InterPro", "id": "IPR042340", "properties": [{"key": "EntryName", "value": "FCER1G"}]}, {"database": "PANTHER", "id": "PTHR16803", "properties": [{"key": "EntryName", "value": "HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR GAMMA-SUBUNIT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR16803:SF0", "properties": [{"key": "EntryName", "value": "HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT GAMMA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF11628", "properties": [{"key": "EntryName", "value": "TCR_zetazeta"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDVQRRGVFVLFVLLVPVSCDNDFFSEPITCYVLDCILVIYCLIATAFYFKEKFSDLAPEAVAASENNEDVYQELERPTDTDPYQVLNP", "length": 89, "molWeight": 10179, "crc64": "4A0FC2C622587EA1", "md5": "32217BCA38DD3959DFDE1B8099D2881C"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Region": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D37020"}, "cluster_size": 2, "family": "Sciaenidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJI8", "uniProtkbId": "A0AAU7LJI8_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28236.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28236.1"}], "value": "MADS41"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28236.1"}], "value": "MADS41"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 81, "modifier": "EXACT"}, "end": {"value": 141, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28236.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28236.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400876", "properties": [{"key": "ProteinId", "value": "XBP28236.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00265", "properties": [{"key": "EntryName", "value": "MADS_MEF2_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050142", "properties": [{"key": "EntryName", "value": "MADS-box/MEF2_TF"}]}, {"database": "InterPro", "id": "IPR033896", "properties": [{"key": "EntryName", "value": "MEF2-like_N"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR48019", "properties": [{"key": "EntryName", "value": "SERUM RESPONSE FACTOR HOMOLOG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00350", "properties": [{"key": "EntryName", "value": "MADS_BOX_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEQSFSAMVSQWQRQRGTHFLFSKGREAPILWELGTRSAAMASPFLAHRTKIATLSSMEGRGSVDSLLVTSEIIKLRVERMGRGKIVIRRIDNSTSRQVTFSKRRNGLLKKAKELAILCDAEVGVMIFSSTSKLYDFASTRGIDL", "length": 145, "molWeight": 16255, "crc64": "30D36C1AD304417A", "md5": "67D2BD8901558733AE780113840C8ACC"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D27F1E"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PAV6", "uniProtkbId": "A0AAU6PAV6_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20567.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20567.1"}], "value": "Venom peptide"}}]}, "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20567.1"}], "value": "U_LCTX_1_Cm35", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20567.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480836", "properties": [{"key": "ProteinId", "value": "WXB20567.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSKLLIIFVAFTLLLAQFSVVESSRLLQKRQLDSLSGATFGR", "length": 42, "molWeight": 4686, "crc64": "5F4BC6DA2D18F0BA", "md5": "68B9F333C9835A99DA3F3AE5FE50D1D5"}, "extraAttributes": {"uniParcId": "UPI0035D36AD5"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96K9C9", "uniProtkbId": "A0AA96K9C9_9ANNE", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Palola sp", "taxonId": 3048018, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25264.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Errantia", "Eunicida", "Eunicidae", "Palola"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25264.1"}], "value": "Hypoxia-inducible factor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Domain", "location": {"start": {"value": 90, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 243, "modifier": "EXACT"}, "end": {"value": 294, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 439, "modifier": "EXACT"}, "end": {"value": 461, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 476, "modifier": "EXACT"}, "end": {"value": 504, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 622, "modifier": "EXACT"}, "end": {"value": 701, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 718, "modifier": "EXACT"}, "end": {"value": 740, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 480, "modifier": "EXACT"}, "end": {"value": 500, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 660, "modifier": "EXACT"}, "end": {"value": 678, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 686, "modifier": "EXACT"}, "end": {"value": 697, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 731, "modifier": "EXACT"}, "end": {"value": 740, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25264.1"}], "value": "Palo1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25264.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354999", "properties": [{"key": "ProteinId", "value": "WNN25264.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd11433", "properties": [{"key": "EntryName", "value": "bHLH-PAS_HIF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000005", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1 subunit alpha"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR014887", "properties": [{"key": "EntryName", "value": "HIF-1_CTAD"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR001610", "properties": [{"key": "EntryName", "value": "PAC"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "NCBIfam", "id": "TIGR00229", "properties": [{"key": "EntryName", "value": "sensory_box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23171", "properties": [{"key": "EntryName", "value": "bHLH_HIF1A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08778", "properties": [{"key": "EntryName", "value": "HIF-1a_CTAD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14598", "properties": [{"key": "EntryName", "value": "PAS_11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00353", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00086", "properties": [{"key": "EntryName", "value": "PAC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MKMPSSGKPKRRNSEKRKEKSRDAARSRRGKETEVYYQLAHQLPLHYNNSTQLDKASIMRLAIAHLKLRKLLGPFRECRETALDKGMDQQYLKAMEGFLFIIGKEGDMMYLSENVTKYLGLSQVDLIGQSIYEFSHPCDHDEIREMLLEKPHHTEVNGEDRVFFVRLKCTLTNKGKSVNLKSAMYKVIRCSGQLITASDAPASMPGLKDDESLTCLMAIGEPIPHPSNIEIPLDSQTFLSRHSLDMKFTYCDDRITDLLGYLPDDLLGESAYDYHHALDSEEVEKAFRNLFSKGQTMTNKYRFLAKNGGFAWVVSQGTIIYNSRTEKPQCVVCVNFVISGVELTKTVMSNIQVKEKENEKPKGFVMSTDTIFHPRTKEHDEDFFRPPELKAKKTNVDDLTHLAPAVSEEMMPLCYGSSDHEEEIVTSKVNLFDDLMMTSSDSVSKPRTELPAPSPAKKPLPFMISLRDDDILDDVGQLGSPITSASSTPSPRPSTSFAASNVNQSNKVSIPQEVDALDLVDDDEPSPSSRVRFTTDFMDEDSVQDINLEMRAPYIPMSGDEDLIFSAVPIPLVDSDEGGNRLMLGITETIFNPKPADTTKATTQTPVSILKMEHAGLKPRLPVGDLARNAGPPKMKRPMETNRLETGPPAAKVARVEVGTSGTPTPTSTMTAAANPPSQSLVNNNQGQTAGAGSSGQNRGSSVLMNLLTKGEDTNYGYSVNKPFTRPSQPPTNSSQVGPSISTQEMLMSPTVTSTTQGQLSILQRLISSDEPSESNGAATTSLLRKLLPRITQFEAEVNVPVQDNSNLLQGAELLKALEIGGINLIPFP", "length": 829, "molWeight": 91403, "crc64": "EFD046B0A5CAC433", "md5": "3B6367370AAFE4535C07DD146D2DC2D6"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 5, "Compositional bias": 5}, "uniParcId": "UPI002B318457"}, "cluster_size": 1, "family": "Eunicidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFH4", "uniProtkbId": "A0AAU7VFH4_TUTAB", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Tuta absoluta", "commonName": "South American tomato moth", "synonyms": ["Tomato leafminer"], "taxonId": 702717, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW50733.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Gelechioidea", "Gelechiidae", "Gelechiinae", "Tuta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW50733.1"}], "value": "Ryanodine receptor"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW50733.1"}], "value": "Ryr"}}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 73, "modifier": "EXACT"}, "end": {"value": 94, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 157, "modifier": "EXACT"}, "end": {"value": 179, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 185, "modifier": "EXACT"}}, "description": "Ryanodine Receptor TM 4-6", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF06459"}]}, {"type": "Region", "location": {"start": {"value": 110, "modifier": "EXACT"}, "end": {"value": 139, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 116, "modifier": "EXACT"}, "end": {"value": 134, "modifier": "EXACT"}}, "description": "Gly residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW50733.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 228, "modifier": "EXACT"}, "end": {"value": 228, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW50733.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW50733.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-2UF1BL6Q14F9M", "citationType": "submission", "authors": ["Muthu Lakshmi Bavithra C.", "Murugan M.", "Balasubramani V.", "Kumar K.", "Harish S.", "Jayakanthan M."], "title": "Identification of ryanodine receptor mutation in insecticide resistant Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) population of South India.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW50733.1"}], "value": "Kng", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW50733.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-2GOADOC4648D6", "citationType": "submission", "authors": ["Muthu Lakshmi Bavithra C.", "Murugan M.", "Balasubramani V.", "Kumar K.", "Harish S.", "Jayakanthan M."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN34937.1"}], "value": "DMP", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN34937.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP934631", "properties": [{"key": "ProteinId", "value": "XBW50733.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "EMBL", "id": "PP995780", "properties": [{"key": "ProteinId", "value": "XCN34937.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "SMR", "id": "A0AAU7VFH4", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0034704", "properties": [{"key": "GoTerm", "value": "C:calcium channel complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042383", "properties": [{"key": "GoTerm", "value": "C:sarcolemma"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0033017", "properties": [{"key": "GoTerm", "value": "C:sarcoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005790", "properties": [{"key": "GoTerm", "value": "C:smooth endoplasmic reticulum"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030018", "properties": [{"key": "GoTerm", "value": "C:Z disc"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005219", "properties": [{"key": "GoTerm", "value": "F:ryanodine-sensitive calcium-release channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006874", "properties": [{"key": "GoTerm", "value": "P:intracellular calcium ion homeostasis"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0014808", "properties": [{"key": "GoTerm", "value": "P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006941", "properties": [{"key": "GoTerm", "value": "P:striated muscle contraction"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR015925", "properties": [{"key": "EntryName", "value": "Ryanodine_IP3_receptor"}]}, {"database": "InterPro", "id": "IPR009460", "properties": [{"key": "EntryName", "value": "Ryanrecept_TM4-6"}]}, {"database": "PANTHER", "id": "PTHR46399", "properties": [{"key": "EntryName", "value": "B30.2/SPRY DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46399:SF8", "properties": [{"key": "EntryName", "value": "B30.2_SPRY DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF06459", "properties": [{"key": "EntryName", "value": "RR_TM4-6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "QQPPSLIDLLGGEQKKKEVQERMEAQAAQQAAMSAIEAESKKAAQGITQPSAVSQIDLSQYTKRAVSFLARNFYNLKYVALVLAFCINFVLLFYKVSTLDSEDGEGSGLGDLISGSGSGRDGSGGGSGDGGSGESGEEDDPLEIVHIDEDYFYMEHVINIAAALHSIVSLAMLIGYYHLKVPLAIFKREKEIARKLEFDGLYIAEQPEDDDLKSHWDKLVISAKSFPV", "length": 228, "molWeight": 24822, "crc64": "1B5BA790430DCBA4", "md5": "7CE2DB655857AC931A1076F151983064"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2, "Domain": 1, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D350F8"}, "cluster_size": 1, "family": "Gelechiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MP40", "uniProtkbId": "A0AA96MP40_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS68456.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS68456.1"}], "value": "DOMON domain-containing protein 2"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 811, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041708470"}, {"type": "Transmembrane", "location": {"start": {"value": 743, "modifier": "EXACT"}, "end": {"value": 772, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 194, "modifier": "EXACT"}, "end": {"value": 235, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 348, "modifier": "EXACT"}, "end": {"value": 475, "modifier": "EXACT"}}, "description": "DOMON", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50836"}]}, {"type": "Domain", "location": {"start": {"value": 547, "modifier": "EXACT"}, "end": {"value": 663, "modifier": "EXACT"}}, "description": "DOMON", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50836"}]}, {"type": "Region", "location": {"start": {"value": 320, "modifier": "EXACT"}, "end": {"value": 394, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 320, "modifier": "EXACT"}, "end": {"value": 336, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 351, "modifier": "EXACT"}, "end": {"value": 374, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 225, "modifier": "EXACT"}, "end": {"value": 234, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-0245", "category": "Domain", "name": "EGF-like domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS68456.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR484743", "properties": [{"key": "ProteinId", "value": "WNS68456.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd09631", "properties": [{"key": "EntryName", "value": "DOMON_DOH"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "CDD", "id": "cd00054", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.260", "properties": [{"key": "EntryName", "value": "Galactose-binding domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR004302", "properties": [{"key": "EntryName", "value": "Cellulose/chitin-bd_N"}]}, {"database": "InterPro", "id": "IPR045266", "properties": [{"key": "EntryName", "value": "DOH_DOMON"}]}, {"database": "InterPro", "id": "IPR005018", "properties": [{"key": "EntryName", "value": "DOMON_domain"}]}, {"database": "InterPro", "id": "IPR000742", "properties": [{"key": "EntryName", "value": "EGF-like_dom"}]}, {"database": "PANTHER", "id": "PTHR46901", "properties": [{"key": "EntryName", "value": "GH04942P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46901:SF2", "properties": [{"key": "EntryName", "value": "GH04942P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03351", "properties": [{"key": "EntryName", "value": "DOMON"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Pfam", "id": "PF03067", "properties": [{"key": "EntryName", "value": "LPMO_10"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00664", "properties": [{"key": "EntryName", "value": "DoH"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00181", "properties": [{"key": "EntryName", "value": "EGF"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF57196", "properties": [{"key": "EntryName", "value": "EGF/Laminin"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50836", "properties": [{"key": "EntryName", "value": "DOMON"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS00022", "properties": [{"key": "EntryName", "value": "EGF_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS01186", "properties": [{"key": "EntryName", "value": "EGF_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50026", "properties": [{"key": "EntryName", "value": "EGF_3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTHGILLSLALCLISFQLPCRAHVSLIFPPARLPRYDFLDNVRTPGPCGVAKGNDGPLTTLLAGSTFDVRIHLAYPHRGGFSLRLLDPNGTVLHYLLPQNSTGLVHDMDGTIQSAEVTLPSGVECSECILQLIRHAAEWAAGANTPYLFWSCADVTVTAVEEDLCGASTCSDHGACTQGACECQPQYYGEYCQFKDECENAADCSSQGACVDTLSTNLPRRQCFCYRGYHGPRCQHTSSLTNADIDESVYTIKRTLNDRLQMYARIVDDELEVALVLQGTGWVAIGVKPQDDQLSSCRADSPGFIPLVQSKRYRVNVTIDEDGGSSEEGSSEEGSSEEGGSSEEGGSSEEGSSEEGSSEEGSSEEEGSSEEGSSEEGGSSEEGGSSSTRLHPMDCTDVVIVGARGSTHRVRDYYTRDRSSPQEDEVYGGQYSLTDAIAREQDGVTRAIFRRKLQTTDRADHSIVDDAMTVIWAFGQVQGDFFHSPASSLEAGQASNRAFYQPDEIKYHGSRTRGQTQINFFTADQPTNEDGCYGSYMDPGCTSPQSCDYRAEWIVTGDHVRVRVIAKVNINSWAAIGFSTDTVMPETDVVLGASDGSRSFIHDRYALARAEPPIDPRQNIMNASAVRVDGFTVLDFVRPLQTDDLTRDVSLTECVFFFFGYNGPVRDYDNGGVGYHRIGPLSSPNRICLSTQCPSLASNSEQQHRRFNITSLDLGVTGTDPTGANPPSQVDSAAVLALRREQFVLYVAVGILSALVLALLFALALVGVCCACGRRGVHDFNRAPLSEQELQSKISADSEDVKSGAANNLYT", "length": 811, "molWeight": 87919, "crc64": "190618C88C37D289", "md5": "F6A50C0E8F5FF212CF502CDFD000A54B"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 3, "Region": 1, "Compositional bias": 2, "Disulfide bond": 1}, "uniParcId": "UPI002B2C1EE9"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7BBT3", "uniProtkbId": "A0AAU7BBT3_9NEOB", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Breviceps mossambicus", "commonName": "Mozambique rain frog", "taxonId": 143669, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44908.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Microhyloidea", "Brevicipitidae", "Breviceps"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44908.1"}], "value": "PRIT domain-containing protein"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 262, "modifier": "EXACT"}, "end": {"value": 548, "modifier": "EXACT"}}, "description": "IgGFc-binding protein N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF17517"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44908.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 618, "modifier": "EXACT"}, "end": {"value": 618, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44908.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9LKRFH5MKF7BD", "citationType": "submission", "authors": ["Zaman S.", "Roelants K."], "title": "Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.", "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44908.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR480788", "properties": [{"key": "ProteinId", "value": "XBE44908.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR035234", "properties": [{"key": "EntryName", "value": "IgGFc-bd_N"}]}, {"database": "PANTHER", "id": "PTHR46534", "properties": [{"key": "EntryName", "value": "IGGFC_BINDING DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46534:SF2", "properties": [{"key": "EntryName", "value": "VWFD DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF17517", "properties": [{"key": "EntryName", "value": "IgGFc_binding"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VPGEPEQYIPGIPGKFNPGKPGIFVPGEPEQYIPGIPGKFNPGKPGIFVPGEPEQFIPGIPGKFKPGEPGQYIPGRPGQYIPGEPGKIVTGQPGQYIPGKPGTYLPGRPGEYIPGTPGKYIPGTSGKFIPGTSGQYIPGAAGQYIPLEGGGVRGNPALWSLLGITSTGKKFVTTIPQNKDSKEEVDHEIMVTGTEPDTEVTITVADDKFTKKITVGKGEAATIPVLLNQEVKGTSLDTHPVVIEANKPISVITSNYKGNSGDTSLALPSNQWGTEYLVSMPSGGSDNERYGLSLTSDSATPVEVTLTGAVTYDGINYKKGDKLSVVLAKHQSIHLKSKEDLSGTKVTSLLPVGVQSERWCADESNGCNQVYEQLRPSTGYGNTFYVPSLSVQPGYDTAYVMPAKDTTVTYNLGDQKIKKQLTAGEQLKIKFSASTPLSINSDEGVQVLVEGKGGPNAGSFLTTIPNVKQYGLYYDVYGQDGFDTNKAIIIAKTSSTSGITIDGLPPSGLNWIEFTGTEYSWAEYSLGSGLSSHSIQHTNSPFGVLSVGYSENKAYASMAACTAGPLTLEGADKWQFEWSSFSTPITYTSSADGGVSVGSGGAYEIPAGTEVTTFEIPE", "length": 618, "molWeight": 65273, "crc64": "82AF5E12415C35DA", "md5": "28D8FC513C0C7C3B89599F4CC005B9BE"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D3C666"}, "cluster_size": 1, "family": "Brevicipitidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S1R1", "uniProtkbId": "A0AA96S1R1_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50076.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50076.1"}], "value": "Uncharacterized protein 14"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 41, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 32, "modifier": "EXACT"}, "end": {"value": 41, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50076.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460153", "properties": [{"key": "ProteinId", "value": "WNS50076.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MGSICSCRRRADAKEQRPPSSPPGGIRFAEPIPMPESPPPTGMIYLTYQELPFTAEELRVALMTGPFRPRGRGEGADATVSKLALKSKPFRPRQVYRSRLG", "length": 101, "molWeight": 11172, "crc64": "B6742BB330F3225E", "md5": "4BE60804F641C257680DAE11B1636E15"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B320935"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6NDK4", "uniProtkbId": "A0AAU6NDK4_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59817.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59817.1"}], "value": "OR63a"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 81, "modifier": "EXACT"}, "end": {"value": 102, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 108, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 172, "modifier": "EXACT"}, "end": {"value": 198, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 231, "modifier": "EXACT"}, "end": {"value": 256, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 277, "modifier": "EXACT"}, "end": {"value": 298, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 304, "modifier": "EXACT"}, "end": {"value": 325, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59817.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59817.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420177", "properties": [{"key": "ProteinId", "value": "WWA59817.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "NRAYIFNKIVIDTTSHIQVTQYNTATMFDKFKHFYNKDNLNYSTGYVDPFEFHQTFYQVLVNFKVADLKNKNPPSYVNQNMFLFINSLMATIIISIACYHGLVTADLPLITEAGTYTIVLIYKMIILNCTRKNLPQYHNFLRAMKKDFQYICSVGEKYRAQYFENQLKTWKICIVICIFNVGIGILMNIFAFLSLFYFQVTHVEDTEQNRPLLFPFWLPNVDLSKSPFYEVFFMFGNVTVVLYTYNFTCELWFIYFSTIIINSMQFSSRCYLWSSDLVLIFNFVLYDVTLSLTFSTLIGTHKGYAGLLSFFKSFILSKIITFLFLNYDY", "length": 329, "molWeight": 38789, "crc64": "85162EE39A548EBE", "md5": "6E7A3246F60150EB9A374B1DF1B98706"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 6, "Non-terminal residue": 1}, "uniParcId": "UPI0035D2CE34"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEM1", "uniProtkbId": "A0AB38ZEM1_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02735.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02735.1"}], "value": "Venom pacifastin 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 149, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044231295"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02735.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517485", "properties": [{"key": "ProteinId", "value": "WXI02735.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MKIILLLFMVVVLVSVETDGRMPCVRGSYFLDTNGCNMCVCIKNSGLSCSRGPCPKDNVNKPHCVPGSKFTKINGCKKCECITAKKNNCLKMFCPGHSPYLTRTKRDLIHIGKSERKCSVGQLYMSKDGCSKCTCMKDGNSACRKVKNC", "length": 149, "molWeight": 16432, "crc64": "54BDC0C02ED3C4AC", "md5": "3339CE734B39AA2ACD63592B5C98D7D9"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BF0FB"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DO84", "uniProtkbId": "AT_STRNX", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Strychnos nux-vomica", "commonName": "Poison nut", "synonyms": ["Strychnine tree"], "taxonId": 28545, "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "asterids", "lamiids", "Gentianales", "Loganiaceae", "Strychnos"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"value": "17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35794473"}], "value": "2.3.1.325"}]}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "35794473"}], "value": "Acyltransferase"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "35794473"}], "value": "SnvAT"}]}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "35794473"}], "value": "AT"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35794473"}], "value": "Malonylransferase involved in the biosynthesis of curare monoterpene indole alkaloids (MIAs), natural products such as strychnine, a neurotoxic compound used as a pesticide to control rodents, and its pharmacologically active derivatives, including brucine, used to regulate blood pressure (PubMed:35794473). Curare alkaloids act as animal glycine receptor antagonists (PubMed:35794473). Catalyzes the conversion of 17,18-epoxy-17-hydroxycur-19-ene (Wieland-Gumlich aldehyde) to prestrychnine, which is spontaneously converted into strychnine and isostrychnine (PubMed:35794473)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "17,18-epoxy-17-hydroxycur-19-ene + malonyl-CoA = prestrychnine + CoA", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:80919"}, {"database": "ChEBI", "id": "CHEBI:57287"}, {"database": "ChEBI", "id": "CHEBI:57384"}, {"database": "ChEBI", "id": "CHEBI:231746"}, {"database": "ChEBI", "id": "CHEBI:231748"}], "ecNumber": "2.3.1.325", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35794473"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:80920"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35794473"}]}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35794473"}], "value": "Alkaloid biosynthesis"}], "commentType": "PATHWAY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q9ZTK5"}], "value": "Monomer"}], "commentType": "SUBUNIT"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35794473"}], "value": "Cytoplasm", "id": "SL-0086"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "35794473"}], "value": "Mainly expressed in roots"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the plant acyltransferase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 464, "modifier": "EXACT"}}, "description": "17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase", "featureId": "PRO_0000461124"}, {"type": "Active site", "location": {"start": {"value": 191, "modifier": "EXACT"}, "end": {"value": 191, "modifier": "EXACT"}}, "description": "Proton acceptor", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q9FI78"}]}, {"type": "Active site", "location": {"start": {"value": 403, "modifier": "EXACT"}, "end": {"value": 403, "modifier": "EXACT"}}, "description": "Proton acceptor", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q9FI78"}]}], "keywords": [{"id": "KW-0012", "category": "Molecular function", "name": "Acyltransferase"}, {"id": "KW-0017", "category": "Biological process", "name": "Alkaloid metabolism"}, {"id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "35794473", "citationType": "journal article", "authors": ["Hong B.", "Grzech D.", "Caputi L.", "Sonawane P.", "Lopez C.E.R.", "Kamileen M.O.", "Hernandez Lozada N.J.", "Grabe V.", "O'Connor S.E."], "citationCrossReferences": [{"database": "PubMed", "id": "35794473"}, {"database": "DOI", "id": "10.1038/s41586-022-04950-4"}], "title": "Biosynthesis of strychnine.", "publicationDate": "2022", "journal": "Nature", "firstPage": "617", "lastPage": "622", "volume": "607"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "FUNCTION", "CATALYTIC ACTIVITY", "PATHWAY", "TISSUE SPECIFICITY", "SUBCELLULAR LOCATION"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OM304295", "properties": [{"key": "ProteinId", "value": "UQZ09626.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "SMR", "id": "P0DO84", "properties": [{"key": "Description", "value": "-"}]}, {"database": "KEGG", "id": "ag:UQZ09626", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "35794473"}]}, {"database": "GO", "id": "GO:0016407", "properties": [{"key": "GoTerm", "value": "F:acetyltransferase activity"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "35794473"}]}, {"database": "GO", "id": "GO:0009821", "properties": [{"key": "GoTerm", "value": "P:alkaloid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "35794473"}]}, {"database": "Gene3D", "id": "3.30.559.10", "properties": [{"key": "EntryName", "value": "Chloramphenicol acetyltransferase-like domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR023213", "properties": [{"key": "EntryName", "value": "CAT-like_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR31623:SF88", "properties": [{"key": "EntryName", "value": "ACYLSUGAR ACYLTRANSFERASE 3-LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31623", "properties": [{"key": "EntryName", "value": "F21J9.9"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02458", "properties": [{"key": "EntryName", "value": "Transferase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNRIGSLYFNTKFVKSKVCNSTYKAFPLIINHHTMASFQIQIISETLIKPSSPTPPSLKQHRFSDYDKTMHHMYIPAAFLYTSHGHGITSTDEVSQLLKNSLSKTLSHYYHFAGRLVGDSHVDCNDMGVKLFEVRVRCPMTEVLKRPNTDAKDLVFPKGLPWSMGEGDILVVAQITYFDCGGIAISTDMSHKIVDVSSIATFMKDWAAMARNSSHQPYPVIVSPTILPMDDIPATAEDDIMKENICQSRRFLFDDSKIVELKAMAANSGVENPTRVEVVTAILHKCAVTASTTALGSFMPNILLLAVNLRSIVSPPLANTSIGNISSCCAISVTHENQMKFPLLVGELRRSKTKLLQNYGKQLKKSELLFLNGTDKAQKLSDGDSFDCFIFTSWCRSPLYEVDFGWGRPVQVYVPSCPIKNTFRLTDTPAQDGIQALVTLEENVMPIFENDEELLAFASLIKDS", "length": 464, "molWeight": 51638, "crc64": "D587174E53FAA15F", "md5": "F7FFAD5788764201A431BB9C194B6401"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 1, "PATHWAY": 1, "SUBUNIT": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Active site": 2}, "uniParcId": "UPI0021852256"}, "cluster_size": 2, "family": "Loganiaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHQ3", "uniProtkbId": "A0AAQ5BHQ3_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519505.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519505.1"}], "value": "Secretory carrier membrane protein 3"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519505.1"}], "value": "SCAMP3"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHQ3"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519505.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519505.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519505.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519505.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL713999", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000497470.2", "properties": [{"key": "ProteinId", "value": "ENSP00000519505.1"}, {"key": "GeneId", "value": "ENSG00000116521.12"}]}, {"database": "HGNC", "id": "HGNC:10565", "properties": [{"key": "GeneName", "value": "SCAMP3"}]}, {"database": "OpenTargets", "id": "ENSG00000116521", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000160917", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}], "sequence": {"value": "MAQSRDGGNPFAEPSELDNPFQVTCASRPLLGGQVDSSRFCRVGLTCIPICDI", "length": 53, "molWeight": 5670, "crc64": "B054C196D3D5D117", "md5": "F0E5C803117310567ACCDBE73D253DBA"}, "extraAttributes": {"uniParcId": "UPI0032C7ECE7"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LH94", "uniProtkbId": "A0AAN0LH94_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34069.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34069.1"}], "value": "Glutamate receptor ionotropic kainate 2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 1054, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043000603"}, {"type": "Transmembrane", "location": {"start": {"value": 673, "modifier": "EXACT"}, "end": {"value": 692, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 765, "modifier": "EXACT"}, "end": {"value": 786, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 990, "modifier": "EXACT"}, "end": {"value": 1015, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 540, "modifier": "EXACT"}, "end": {"value": 966, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00079"}]}, {"type": "Region", "location": {"start": {"value": 433, "modifier": "EXACT"}, "end": {"value": 484, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 515, "modifier": "EXACT"}, "end": {"value": 552, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 436, "modifier": "EXACT"}, "end": {"value": 464, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 465, "modifier": "EXACT"}, "end": {"value": 478, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 517, "modifier": "EXACT"}, "end": {"value": 527, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 533, "modifier": "EXACT"}, "end": {"value": 551, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34069.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34069.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154995", "properties": [{"key": "ProteinId", "value": "WRW34069.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "1.10.287.70:FF:000143", "properties": [{"key": "EntryName", "value": "Probable glutamate receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR013099", "properties": [{"key": "EntryName", "value": "K_chnl_dom"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07885", "properties": [{"key": "EntryName", "value": "Ion_trans_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81324", "properties": [{"key": "EntryName", "value": "Voltage-gated potassium channels"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MCFKFVLLFILFASIESFEYNLVLDFKNNDLINIVKNVFIKNFDRLGFNYVKKINFIDTNFTNNNFCDNLFHENEKIHLVLQDDFDQDNHSNLIQKMMKQLKKPMISINKNQINEWKLLSYSQYNLLIRFIPITSVLSTIVRDLIIKENYKKAAVFMDNTFGNQTTNIAENLSFTELETIINCQNLSINQLKEKLLSLKRLKINNFFILAKSITINKLLEAINQNSMFSKFVNIYVISIDFEKVRCFSCKHATIKIVKPIKPNLHDYFDEYFSINLKSQNRIELFFYFDFLRLIISSADSYLKLINETNYENKIPNLQRNECLKFVLNKTYYDSNEDLSFASNNFNSFVDSDDSNNFNLRKQIVEQTKKTFGFYGDFHLSYDDLDYGYQDILVRFYSEHYLNKKISTEVISDWSFDPIEGNIFLNRHLLEEDDEKTENTEETQEKKDEPDKQKEEKNDKKKDDSETNTDAEKEEENAEDNEKNNKVKDSRVTVFIIEHPPFIMKRVIEKPKEVAVATTTTTTTTTQATKEKDGDEAEEETEGEEDGEEEEEEKKIDFEYYGFLIDLFNLIKEELILRKTPFPDYKFEEIEVLKDVEKMFYGGDRKTEFSGMMKRINETETDAFALAPLSITASREFVIEFSEPFFHNYGIAILMKKPRIKPHFFKFITVLESKVWACITGAYLFTSILLTIFEQFSPQKYKQKKEIKLKRKKQINDKEEDLDDLDSLSSNREFTFKESLWFCITSLTPQGGGEAPRSIYGRLVAATWWLFGFIVIASYTANLAAFLTVSRLESKIDDLKKLSKQYKVRYAPVDDTATDFYFIQMAEIEEKFYEIWKDMSLNDSLTENERAKLAVWDYPVSDQYTKIAAQMVEVEKPKGIINALKKVRDSPDHTDGFAVLAGSLTVDYFANLFCDVYRVGEDFSLRPIALGAKKTNSVDLLKLINPIIIKLEEEGVIEDLKAKYWDNNVNKNNCEDYRKLSNGISLFNSGGVFIIIITGVILTLFLLQLENFIIVYMKVYRAKKQKALMKAPSLESKNNDSFFKSIFCCLRSKTL", "length": 1054, "molWeight": 123121, "crc64": "040694B9235104DF", "md5": "0A95409603AD407C8D9E903C518F1A84"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 3, "Domain": 1, "Region": 2, "Compositional bias": 4}, "uniParcId": "UPI00325009B8"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QL20", "uniProtkbId": "A0AAU0QL20_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56454.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 43, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 78, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 287, "modifier": "EXACT"}, "end": {"value": 306, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 312, "modifier": "EXACT"}, "end": {"value": 332, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 380, "modifier": "EXACT"}, "end": {"value": 401, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56454.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56454.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970347", "properties": [{"key": "ProteinId", "value": "WPO56454.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF44", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 13A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEGIEDYPKEYVDPFLLSLGLLKQCNIVFPPNTDSFWKSNKRLLYMVPLVILHYIIMTSFIIKMFIEGLDVFEEVNVIPMWCIITGSTTKQILLMLKRKDVRETVTQLGATWRTSGLDEEQIKIKNTVLKWANLLQNLVCKFSIATSWQYIMMPLCETIVRTFVLRQEDVKLKLPFPGIYPFEITGWYRYLTVYTFQFYCLFRAVYGYLGSDWIMSILSAELSIQFLILQEDLKKLNPQVRESMQIQERDDEITWNKRKPSDIKIFIRRHQKIIELTNDVNAIFSKLIFTNLLFTSINICFFAIAVRAGAGYIWNNCASIIVLIINIFSLCFSSEMIYTTSAGIADAAASNPWYLGSLTYQKTMMFIIMRSQKSCRLSSLAYWPIGISTFTAVLTTTWSYLSLANQMYDGRD", "length": 412, "molWeight": 47845, "crc64": "FE0CB59910C47C10", "md5": "B8E30DADB6E4E906C78FAB96D8DD8908"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 5}, "uniParcId": "UPI0030913B7B"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0PBQ5", "uniProtkbId": "A0AAF0PBQ5_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenuipotamon purpura", "taxonId": 2875585, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}], "value": "Elongation factor 1-alpha-like protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}], "value": "scaffold1146986"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042194094"}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 152, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}], "id": "KW-0251", "category": "Molecular function", "name": "Elongation factor"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}], "id": "KW-0648", "category": "Biological process", "name": "Protein biosynthesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}], "value": "XDZL02", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}], "value": "XDZL02", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69276.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR517329", "properties": [{"key": "ProteinId", "value": "WMS69276.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0003746", "properties": [{"key": "GoTerm", "value": "F:translation elongation factor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "LLSSLCGLATAFLLCYFLDDTYSHRLLHVTHGEAAQRGVFLEGLNAHGFAGDHLHNARVARLNLLGVGLNLFASTPVYLLDELGKLAGDVGGVAVQHRRVASLDLARVVQHNHLGCEISSFPGRVILGICNEASLQVLHSHVLHIEAHVVAR", "length": 152, "molWeight": 16365, "crc64": "6636CF18EF401095", "md5": "F46BB910F7BA381491B74296AB00B7B3"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2F3758"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFU8", "uniProtkbId": "A0AAU7VFU8_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67477.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67477.1"}], "value": "Pumilio-like protein 3"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67477.1"}], "value": "pumilio3"}}], "features": [{"type": "Domain", "location": {"start": {"value": 158, "modifier": "EXACT"}, "end": {"value": 504, "modifier": "EXACT"}}, "description": "PUM-HD", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50303"}]}, {"type": "Repeat", "location": {"start": {"value": 216, "modifier": "EXACT"}, "end": {"value": 251, "modifier": "EXACT"}}, "description": "Pumilio", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00317"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 39, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 66, "modifier": "EXACT"}, "end": {"value": 137, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 11, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 39, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 75, "modifier": "EXACT"}, "end": {"value": 84, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 121, "modifier": "EXACT"}, "end": {"value": 137, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67477.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67477.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750682", "properties": [{"key": "ProteinId", "value": "XBW67477.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005730", "properties": [{"key": "GoTerm", "value": "C:nucleolus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0003729", "properties": [{"key": "GoTerm", "value": "F:mRNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006417", "properties": [{"key": "GoTerm", "value": "P:regulation of translation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.25.10.10", "properties": [{"key": "EntryName", "value": "Leucine-rich Repeat Variant"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011989", "properties": [{"key": "EntryName", "value": "ARM-like"}]}, {"database": "InterPro", "id": "IPR016024", "properties": [{"key": "EntryName", "value": "ARM-type_fold"}]}, {"database": "InterPro", "id": "IPR012959", "properties": [{"key": "EntryName", "value": "CPL_dom"}]}, {"database": "InterPro", "id": "IPR033133", "properties": [{"key": "EntryName", "value": "PUM-HD"}]}, {"database": "InterPro", "id": "IPR040059", "properties": [{"key": "EntryName", "value": "PUM3"}]}, {"database": "InterPro", "id": "IPR001313", "properties": [{"key": "EntryName", "value": "Pumilio_RNA-bd_rpt"}]}, {"database": "PANTHER", "id": "PTHR13389", "properties": [{"key": "EntryName", "value": "PUMILIO HOMOLOG 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13389:SF0", "properties": [{"key": "EntryName", "value": "PUMILIO HOMOLOG 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08144", "properties": [{"key": "EntryName", "value": "CPL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00025", "properties": [{"key": "EntryName", "value": "Pumilio"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "SUPFAM", "id": "SSF48371", "properties": [{"key": "EntryName", "value": "ARM repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50302", "properties": [{"key": "EntryName", "value": "PUM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50303", "properties": [{"key": "EntryName", "value": "PUM_HD"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGKPKKQGKKSKSMDFEEVEIEEHEIDDEINYNDNDSEMSIDVDEPIVEMKPKKNKKTEIVVDKKLKKSEKAVNKSVNPTQTMQDFKEAVKKVRKEAKKPEIETKKVTPGKKRKQPDSQTESDKKRKLDEMTFKERKDVRKKQNKNYENAKIALRLWEKLRVFDQSPDERKKVYDELYRYVAGNAAHFINAHDTARVVQTLIKYGTAEQRNTLFNELKEHILEMMKSLYAKFIVRKFLKYGTKGQRDCIFTALKGHIRKLVRHKEAADIIECAYNMFANATQRAAMVEEFYGPLFLIYKTDENRTLAQVLVAHPDKSESILTSMKETLTALVEKNSLQYSFVHKLFLDYFLLASDKLRAEMIETIRESTIHMLHTREGARVAMSCLWHGTAKDRKATVKSFKNLVEKICKEEYGHMVMLALFDVVDDTKLVSKAILDELLKCVDVLAGDQYGRKVLLYLLQSRDTLHFHPDIVSVLTQGDGNAHSKKDAQIRREELLTHVSRPLVQWIAQHAQEYSVSSSMLPLIVSIIQHVKCDRTEAMRSISQVAALPYSAGADHIVEHPAGHLTLKRLIVSDNERIKNSETVLFSNILLDVVPETSLTSWTSCNRGCFICVSLLEVQNEEVTKRVAERLSSAKPALKTRTFKGAQILLEKLK", "length": 655, "molWeight": 75246, "crc64": "F2AC19DECD897EDD", "md5": "4794F9EB2824370C36D0E4261D65934F"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Repeat": 1, "Region": 2, "Compositional bias": 4}, "uniParcId": "UPI0035D2E6CC"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEA8", "uniProtkbId": "A0AB38ZEA8_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71762.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71762.1"}], "value": "Venom cystatin 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044213209"}, {"type": "Domain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "Cystatin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00043"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71762.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510837", "properties": [{"key": "ProteinId", "value": "WXH71762.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004869", "properties": [{"key": "GoTerm", "value": "F:cysteine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00042", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.450.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000010", "properties": [{"key": "EntryName", "value": "Cystatin_dom"}]}, {"database": "InterPro", "id": "IPR046350", "properties": [{"key": "EntryName", "value": "Cystatin_sf"}]}, {"database": "Pfam", "id": "PF00031", "properties": [{"key": "EntryName", "value": "Cystatin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00043", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54403", "properties": [{"key": "EntryName", "value": "Cystatin/monellin"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MISFRVILIFIIGIVIQDSFTFASCPGCLSDMDVNDGELKRTLNLVMSAQNTNDELLKIISAKYQIVAGIRYVVKFEVKNPQSNQTKTCTSSYVVRKWISPNPESIDFSCE", "length": 111, "molWeight": 12487, "crc64": "78F510A2D799CCA1", "md5": "5779E2829EBCBDFE43335DABD77D2D27"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388BF3FF"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFQ0", "uniProtkbId": "A0AAU7VFQ0_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67479.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67479.1"}], "value": "Tudor domain protein 2"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67479.1"}], "value": "tudor2"}}], "features": [{"type": "Domain", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "RRM", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50102"}]}, {"type": "Domain", "location": {"start": {"value": 340, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "MYND-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50865"}]}, {"type": "Domain", "location": {"start": {"value": 476, "modifier": "EXACT"}, "end": {"value": 542, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1012, "modifier": "EXACT"}, "end": {"value": 1071, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1272, "modifier": "EXACT"}, "end": {"value": 1330, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1549, "modifier": "EXACT"}, "end": {"value": 1606, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 1834, "modifier": "EXACT"}, "end": {"value": 1894, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 2031, "modifier": "EXACT"}, "end": {"value": 2089, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Domain", "location": {"start": {"value": 2299, "modifier": "EXACT"}, "end": {"value": 2356, "modifier": "EXACT"}}, "description": "Tudor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50304"}]}, {"type": "Region", "location": {"start": {"value": 159, "modifier": "EXACT"}, "end": {"value": 313, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 627, "modifier": "EXACT"}, "end": {"value": 669, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1405, "modifier": "EXACT"}, "end": {"value": 1486, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1710, "modifier": "EXACT"}, "end": {"value": 1730, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 260, "modifier": "EXACT"}, "end": {"value": 303, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 643, "modifier": "EXACT"}, "end": {"value": 669, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1461, "modifier": "EXACT"}, "end": {"value": 1472, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1710, "modifier": "EXACT"}, "end": {"value": 1719, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 2487, "modifier": "EXACT"}, "end": {"value": 2487, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67479.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00176"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00134"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67479.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67479.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750684", "properties": [{"key": "ProteinId", "value": "XBW67479.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.30.30.140", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "Gene3D", "id": "2.40.50.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "Gene3D", "id": "3.30.70.330", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "6.10.140.2220", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR014002", "properties": [{"key": "EntryName", "value": "Agenet_dom_plant"}]}, {"database": "InterPro", "id": "IPR012677", "properties": [{"key": "EntryName", "value": "Nucleotide-bd_a/b_plait_sf"}]}, {"database": "InterPro", "id": "IPR035979", "properties": [{"key": "EntryName", "value": "RBD_domain_sf"}]}, {"database": "InterPro", "id": "IPR000504", "properties": [{"key": "EntryName", "value": "RRM_dom"}]}, {"database": "InterPro", "id": "IPR035437", "properties": [{"key": "EntryName", "value": "SNase_OB-fold_sf"}]}, {"database": "InterPro", "id": "IPR002999", "properties": [{"key": "EntryName", "value": "Tudor"}]}, {"database": "InterPro", "id": "IPR050621", "properties": [{"key": "EntryName", "value": "Tudor_domain_containing"}]}, {"database": "InterPro", "id": "IPR002893", "properties": [{"key": "EntryName", "value": "Znf_MYND"}]}, {"database": "PANTHER", "id": "PTHR22948:SF29", "properties": [{"key": "EntryName", "value": "FI02030P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR22948", "properties": [{"key": "EntryName", "value": "TUDOR DOMAIN CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00567", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "Pfam", "id": "PF01753", "properties": [{"key": "EntryName", "value": "zf-MYND"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00743", "properties": [{"key": "EntryName", "value": "Agenet"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SMART", "id": "SM00333", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "SUPFAM", "id": "SSF144232", "properties": [{"key": "EntryName", "value": "HIT/MYND zinc finger-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54928", "properties": [{"key": "EntryName", "value": "RNA-binding domain, RBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63748", "properties": [{"key": "EntryName", "value": "Tudor/PWWP/MBT"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "PROSITE", "id": "PS50102", "properties": [{"key": "EntryName", "value": "RRM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50304", "properties": [{"key": "EntryName", "value": "TUDOR"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "PROSITE", "id": "PS01360", "properties": [{"key": "EntryName", "value": "ZF_MYND_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50865", "properties": [{"key": "EntryName", "value": "ZF_MYND_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MESYDPMRDDYNDGSFNSYLTSTGERFVRADCDSADKSKMEIQLFIGGIPVDHYDERRIQNMLSSAGDVKRVDMKRGHSYQNNCCIAFATVAGLADANRIIEKYDNYLLPFPGVGTSTLKINFARARNSVPTVPKVTLIPPKYAPVPGGKTLKRLPDFPAGSTQGTINFHSPGGDTFPEAAVSHAGPDLKAISDSTQESVGRGKYLRSKMDGDRRSSGSSQNGPGGSVGRPSGRTTMDRPGGRSSGGSCGVTDDAMSDCSIGSGTSAHSKSVNQQGQVSANQQRFGQSSTNQRAAQGQTSINQRAVRGADQEVSMVTSGRLPKHISSVKTIEPQGPLKPCVLCGKPADKRCQPCKIPTYCSVECQKEHWPSHKAICQFATRSRQEEELLSRFDINIGEEVYSRETDAYLKENGVLPAQLGHGQLDIKKPVQVVLTDIKSPDELWVCIEDDLLEHAKLQKSLNEYYSAEDRRQQKAALDLGDLCVAHFSDDYGSSWCRAIVEKLCGTAAQGSSLVSLRYIDYGNSEQVDKTKVYEMAPEFTKRSQTALRCRLDVVPGDGGDSWSIESLKLLRELISCLKAYVMTPLSFTGQVYTVQLNSLTEGWSASDRLVAAGVAVRESKSINNQSKLINTAGDERDGGKITKGSTDGANLNSNNNKTGDGNTEPNQHSSMKTQFSATVRELNIPNPHYPTAAKRLYSGREVKVRVQQVVTPGQFWVQFVSLEEYGELRKLEETMTEHYNNKSRAHGFTPNVHMLFGAHCAGRWYRAQVLNYNPISVQVLLLDYGRRTSVPVGQLHSLEGQFCSLPFQAVRCRLATIKSPLTERGEWPVEAVEFMNEALVSTGRSGGGCLEGVVCGVNDSAVEVELAGVDRGATVGLSDMLLRAGLADRALDDGDETMRNKWLSGVGRGSKFSGSLVESPVPGNPLEPIIESPTTRASTNQSLATPLTQLPTLSSLGRRSYSVGETLTVSVVHTEAQPATLYVQVCSDMHDIVQLQAELNAPECVHALQENPAHEEIVCALFDDDQNWYRGLVLQPSVNGGNVVVKFIDYGNTAEVKPTRVAHLHTKFVKFPVFGVKVKLAGLGDVGDYKIGAEFFAQYSSVEMTIVDEAESGYVVKLASEAGKSINDVIAEKCTSSLTKSAISVTTKVETKSEEGHPDGVNERANLKGSSIGDCPVVYKQADLPNDPLVVGETYSALVSVATDVESFYVQIVNKKSVELIVQIETDMSRSFSSAGSDNMAAGGDSRLVKGLASDGGDSLRGAGDIGVMGSIARVGEMVAACYIVDGLWYRAVVEEITGKTLSVRFVDYGNANEVTMDRVRCLNDSLVRVPALAYNCVLAGSEGLTVNRENWRESYLGPCSTMYSMKVINRRDSLYVVDLVDSATQQNVLDKLLADGIFHKGGYDGTPASTTRGTMRFGSVPSGMENSGVGRRNSNDGGGKSTAVIAESGRLTSRVDGIESRSSGKQGSVTSSDDDKFKSNRSGSASMTNVSLARPAVSLGEVVAVVHVNSPQDFYIQHTDAQSVQKISTLLESLASFVASPQSKTPASLRPGSRVLAMFGECWYRAEVLETDEHGEAHVAFVDFGNTEFVMINETKLLPPEFDVDIIPACAVRCSIAGIKPVNTGVKPVSTGMRNKYEWSMDAIQWFKNSFENKLLSVCSIDNQNCDGGNVICLDIVLKEEDGGGSIKDMIVRKEFAEIFARDVSAAPTTSSTCNSTPKPVRSPVTDQVTTSESECEARRASARKNEPKVTANVETTVLTSGYCSDSMAARGGSAVVEKSVPLRSSTRVNIVHVVSPGEFYAQAINAESQQQFNDLVLKMNQYYGAGTNLPKHAGFSEGMFVAAKLDGVWYRAVVLDSQAGLISVDVRFIDFGDTARVSFNSLEDLKEEFARCLPSQALKCQILGGEKASWSKEALEWFKGECSGKDLYVKDCISLEGGAAYAVDVWKDANSQQSSIKEELVRKGYLKEKLAVESHAELKIEDEVVVSFANNPSDFYVQIKDQRVQQQLCDILINLTETAEDPSFHLATPPSVGDLISALFDGDYYRGEVLAIDLQQRSATVHFFDFGNSSVVSLSDCRVLPPDCIKDISRLAVNCRLSGIKPVSGSWSEEAVSWFKAYENKVLSICDVQKLSAGRYLIGLREREGERERVGGSLVNRGFAARTNADDDVKQFTGKAVCSTDNRSHIVVDNKETKAMKKILSSQSNTEICNVVNSSVNKTSESKENIRSDAEICSDISSIQKKLGSAPELRNDMEVIVVHTRSPAEFYVQIKNDQSVELVFSLQQHYANQTSIAGDFSPAAGDLVAALDAGCWFRAVIQENLQNGRFKVFYVDFGNSDTVSSGDVRPLPVELITMAPSLAIKCDILDVVGSGVNGVWSAEALDWFTMNCENGQYRVNSVKRRENIFSVDLVALNGGKSIREEMISVGMASQTPPESLSLDCQRPQASAEDLKSNMAAGELRPVSGDTVRVGACVSPSHFYCYSVRT", "length": 2487, "molWeight": 270125, "crc64": "A9650D4BAAA38E5C", "md5": "1CFA33233EC16FE063E6578C1B0F0B4D"}, "extraAttributes": {"countByFeatureType": {"Domain": 9, "Region": 4, "Compositional bias": 4, "Non-terminal residue": 1}, "uniParcId": "UPI0035D33457"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LJ29", "uniProtkbId": "A0AAN0LJ29_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34055.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34055.1"}], "value": "Glutamate receptor ionotropic kainate 2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 28, "modifier": "EXACT"}, "end": {"value": 1097, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042850754"}, {"type": "Transmembrane", "location": {"start": {"value": 552, "modifier": "EXACT"}, "end": {"value": 574, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 632, "modifier": "EXACT"}, "end": {"value": 654, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 833, "modifier": "EXACT"}, "end": {"value": 854, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 427, "modifier": "EXACT"}, "end": {"value": 796, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00079"}]}, {"type": "Region", "location": {"start": {"value": 889, "modifier": "EXACT"}, "end": {"value": 969, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 896, "modifier": "EXACT"}, "end": {"value": 907, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 917, "modifier": "EXACT"}, "end": {"value": 928, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 938, "modifier": "EXACT"}, "end": {"value": 966, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 511, "modifier": "EXACT"}, "end": {"value": 511, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 516, "modifier": "EXACT"}, "end": {"value": 516, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 682, "modifier": "EXACT"}, "end": {"value": 682, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 683, "modifier": "EXACT"}, "end": {"value": 683, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 733, "modifier": "EXACT"}, "end": {"value": 733, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Site", "location": {"start": {"value": 661, "modifier": "EXACT"}, "end": {"value": 661, "modifier": "EXACT"}}, "description": "Crucial to convey clamshell closure to channel opening", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Site", "location": {"start": {"value": 779, "modifier": "EXACT"}, "end": {"value": 779, "modifier": "EXACT"}}, "description": "Interaction with the cone snail toxin Con-ikot-ikot", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 745, "modifier": "EXACT"}, "end": {"value": 812, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34055.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34055.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154981", "properties": [{"key": "ProteinId", "value": "WRW34055.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0038023", "properties": [{"key": "GoTerm", "value": "F:signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000060", "properties": [{"key": "EntryName", "value": "Glutamate receptor ionotropic, kainate 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.287.70:FF:000010", "properties": [{"key": "EntryName", "value": "Putative glutamate receptor ionotropic kainate 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR001508", "properties": [{"key": "EntryName", "value": "Iono_Glu_rcpt_met"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00177", "properties": [{"key": "EntryName", "value": "NMDARECEPTOR"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81324", "properties": [{"key": "EntryName", "value": "Voltage-gated potassium channels"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKLKNLLNVFLNVSFLILLFKTEISKSIIRDEEINVAAIFQSSNSYNPALVGFQNGISYANRFILRGIRLNPIITYIKEDDSFEAINNVCQLIQQRSIWAMFTSESLSINWIIPSIANNLHIPNIQSIWDYSNSKKIFDNELKTNFTINIYPDASLLSQAYKDWTEASDLKALTIIYEKKEDLIFIKDLLELNSPINKVRISIKEHNIESIDFKKLLKDSKLKNGDNFILAISLDKVTELLKQADELGLVTEYNKYLITNLDAFKLNYDFLEENNKNITTLSLINFDIFKNKELAIIASEYKHEEALMFDAVITFAKALLHLKNSAASIQSPAVSCRRSNRAKWESGKLIMNHIKNTMFEGLTGPIMFNENGQRVNFTMRILAIQQYDTMFNQTGFWTVDRNIEIARAKKEEVEEDIKKMLRNRRLPLRVVSMMNKPYVFQNPVGTDDEQVLSNFINLNKNHTGFCVELLDKLQERLGFVYEIILLNTTSSKDLLEAVKQQKADMAIADITITKERQAEVDFTMPFLSLGIAILFSKSSVETKDLFSFMQPFNVKVWLLLGTACLGVSLLLYIISRISPYEWVSGHPCEDEPEEMENQFSLGNCLWFVLGSIMQQGSDLSPRAPSTRLLANVWAFFTLIMTSSYTANLAAVLTLSGLEIEIKSVEDLAKQIKVKYGLLKDGSTHKFFTNSQHPIYQRMYSYMESIEKVEKVYTKENFEGVKRVLKGNFAFLMESTTLEFFTNQHCNLTQIGNLLDRKGYGIVLKQGSPYTSLLSNAILKLQEEQYLSYLRTKWFNEYPATLRQLKTPWLSKCPKIEETSGGAKEMEVQDVGGVFIVLIVGLSIGILFSLVEIWWKAKKIARHEREHVCVLIWREFHRILTLGGSTTTDNPLLMPKSNSTSNQNVSNSYRRSSTMHSVNEESNKNETAKKIKKNKSSSGLTKKSTNTTLNQPYPSFSISTNGLPSLSHSKKEYKNDYDKKMKNSFEMPLIEPPKGYEQGFKNDQTNIVTKNKNRPSFFINQQLNNFPSYSKDQIDPKNIFLQKNTNFDSINQSSRKSSLKNQDDNNLRRRSYLIESPIVWPKNLNTLDDDLDNNSPYS", "length": 1097, "molWeight": 125826, "crc64": "FF7A8416101218BF", "md5": "3301E22B1478975656533E56A3DF2BBC"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 3, "Domain": 1, "Region": 1, "Compositional bias": 3, "Binding site": 5, "Site": 2, "Disulfide bond": 1}, "uniParcId": "UPI003245E2ED"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BH80", "uniProtkbId": "A0AAQ5BH80_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519329.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519329.1"}], "value": "Succinate dehydrogenase complex iron sulfur subunit B"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519329.1"}], "value": "SDHB"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BH80"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BH80"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519329.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519329.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519329.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519329.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL049569", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000714038.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519329.1"}, {"key": "GeneId", "value": "ENSG00000117118.12"}]}, {"database": "HGNC", "id": "HGNC:10681", "properties": [{"key": "GeneName", "value": "SDHB"}]}, {"database": "OpenTargets", "id": "ENSG00000117118", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000013558", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}, {"database": "Gene3D", "id": "3.10.20.30", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR012675", "properties": [{"key": "EntryName", "value": "Beta-grasp_dom_sf"}]}], "sequence": {"value": "MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKHLWLLCNEHQWRQHSSLHPKD", "length": 88, "molWeight": 9916, "crc64": "6BD0A198000E5360", "md5": "FEDFE24970CCD980D52B58B4B08377E0"}, "extraAttributes": {"uniParcId": "UPI0032C78D48"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMR0", "uniProtkbId": "A0AAU0QMR0_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56513.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56513.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 86, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043860405"}, {"type": "Transmembrane", "location": {"start": {"value": 65, "modifier": "EXACT"}, "end": {"value": 83, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56513.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56513.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56513.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970406", "properties": [{"key": "ProteinId", "value": "WPO56513.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MACLVQLLLFYWHSNEVCRESTLVSYGTFCSKWTQAGPLVQREVALLGLTTDKRLVFRAGPFNEMTLTTFIAVSVYFYLMILYTRW", "length": 86, "molWeight": 10011, "crc64": "DCB44074C9B6A4B7", "md5": "B09F20967FB8C71D81BEF97B6995F671"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1}, "uniParcId": "UPI0030886E53"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LP86", "uniProtkbId": "A0AAN0LP86_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06410.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06410.1"}], "value": "Nicotinic acetylcholine receptor"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06410.1"}], "value": "nAChR"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003328"}], "value": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009237"}], "value": "Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 210, "modifier": "EXACT"}, "end": {"value": 233, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 245, "modifier": "EXACT"}, "end": {"value": 263, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 275, "modifier": "EXACT"}, "end": {"value": 298, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Transmembrane", "location": {"start": {"value": 491, "modifier": "EXACT"}, "end": {"value": 509, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}]}, {"type": "Domain", "location": {"start": {"value": 3, "modifier": "EXACT"}, "end": {"value": 208, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel ligand-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02931"}]}, {"type": "Domain", "location": {"start": {"value": 216, "modifier": "EXACT"}, "end": {"value": 507, "modifier": "EXACT"}}, "description": "Neurotransmitter-gated ion-channel transmembrane", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF02932"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06410.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000687"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WTM06410.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP191249", "properties": [{"key": "ProteinId", "value": "WTM06410.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0022848", "properties": [{"key": "GoTerm", "value": "F:acetylcholine-gated monoatomic cation-selective channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004888", "properties": [{"key": "GoTerm", "value": "F:transmembrane signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007271", "properties": [{"key": "GoTerm", "value": "P:synaptic transmission, cholinergic"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "CDD", "id": "cd19064", "properties": [{"key": "EntryName", "value": "LGIC_TM_nAChR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.70.170.10:FF:000013", "properties": [{"key": "EntryName", "value": "Acetylcholine receptor subunit alpha"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.20.58.390:FF:000022", "properties": [{"key": "EntryName", "value": "Nicotinic acetylcholine receptor subunit alpha4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.70.170.10", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel ligand-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.390", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR006202", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd"}]}, {"database": "InterPro", "id": "IPR036734", "properties": [{"key": "EntryName", "value": "Neur_chan_lig-bd_sf"}]}, {"database": "InterPro", "id": "IPR006201", "properties": [{"key": "EntryName", "value": "Neur_channel"}]}, {"database": "InterPro", "id": "IPR036719", "properties": [{"key": "EntryName", "value": "Neuro-gated_channel_TM_sf"}]}, {"database": "InterPro", "id": "IPR038050", "properties": [{"key": "EntryName", "value": "Neuro_actylchol_rec"}]}, {"database": "InterPro", "id": "IPR006029", "properties": [{"key": "EntryName", "value": "Neurotrans-gated_channel_TM"}]}, {"database": "InterPro", "id": "IPR018000", "properties": [{"key": "EntryName", "value": "Neurotransmitter_ion_chnl_CS"}]}, {"database": "InterPro", "id": "IPR002394", "properties": [{"key": "EntryName", "value": "Nicotinic_acetylcholine_rcpt"}]}, {"database": "PANTHER", "id": "PTHR18945", "properties": [{"key": "EntryName", "value": "NEUROTRANSMITTER GATED ION CHANNEL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02931", "properties": [{"key": "EntryName", "value": "Neur_chan_LBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02932", "properties": [{"key": "EntryName", "value": "Neur_chan_memb"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00254", "properties": [{"key": "EntryName", "value": "NICOTINICR"}]}, {"database": "PRINTS", "id": "PR00252", "properties": [{"key": "EntryName", "value": "NRIONCHANNEL"}]}, {"database": "SUPFAM", "id": "SSF90112", "properties": [{"key": "EntryName", "value": "Neurotransmitter-gated ion-channel transmembrane pore"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63712", "properties": [{"key": "EntryName", "value": "Nicotinic receptor ligand binding domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00236", "properties": [{"key": "EntryName", "value": "NEUROTR_ION_CHANNEL"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVDYNRLVRPVKNNNETVNVSFGLKLTQLIDLNLKSHVLSTNVWLEHQWYDHRLKWEPLENGKINRLYLPVDQIWLPHIVLLNSADGNYLPKLTNKVIVNSNGLVEWQPPAIFKSRCNIDIRWFPFDSQSCILKFGLYTNDAINIRLNFINQSIVKNNLIQNGIDLTEFNINSEWDLMSVPAQIIHKHSIAYSNSAQEILFKINLRRKKLYYFVHLVLPCIMISILSIFVFYLPSNSKEKMTLSVSILVCLSIFLYIVSEIVSTNSLSTPLIGRYLFFTLFQVTLSILLSTLIVNIYYKSETNLKANCRLRKFLLRFLPNLLKMQPLNSILCSAQFYATSSNSRLSTSGFYYSSACQNIVASYHSKNLQSEIELNSSLVKSEEKNENTSLTQKNHVLENFNTTSSTSSSNDSSNEFMKNFSCINNMEHLKENFLTSNSCLKENQKNLKKKPIQFEKAVKNLNFLANHIHNAEQYSKVQEEWRFLAIVLDRLFLWIFGLSCLIGWLFILLQAPSLYDNQQPIDRQETEIYL", "length": 530, "molWeight": 61455, "crc64": "80D67821FB2F4F47", "md5": "BE904932F9835A80C4F3246CD491B0E4"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 4, "Domain": 2}, "uniParcId": "UPI00325178FC"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S1P9", "uniProtkbId": "A0AA96S1P9_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50031.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50031.1"}], "value": "Uncharacterized protein 2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 193, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041692657"}, {"type": "Region", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 99, "modifier": "EXACT"}, "end": {"value": 193, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 49, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 110, "modifier": "EXACT"}, "end": {"value": 187, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50031.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460108", "properties": [{"key": "ProteinId", "value": "WNS50031.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MAGSKLILLALAATMLAIAVMPVSGTNWGTTESTTEPTTEATTEATTPEPTEPPTKPQHHHSLIWRIKACWWRCSKGSDIGCFVRCLYSGHHGFNYVKKPFPGNNDNSASGSRSGSRSGSKSGSRSGSKSGSRSGSKSGSRSGSKSGSRSGNQFRSRSFSKSQSRSFSKSGSRSGSRSRSSSRSGGQKNHHQW", "length": 193, "molWeight": 20520, "crc64": "1BA842BB0CD0C2D0", "md5": "AB64773956F72D41355E92DF2EFD457E"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 2, "Compositional bias": 2}, "uniParcId": "UPI002B2DF118"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8L138", "uniProtkbId": "A0AAU8L138_HALDU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28597.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28597.1"}], "value": "SFRPa"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010054"}], "value": "Belongs to the secreted frizzled-related protein (sFRP) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 292, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043784291"}, {"type": "Domain", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "FZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50038"}]}, {"type": "Domain", "location": {"start": {"value": 162, "modifier": "EXACT"}, "end": {"value": 292, "modifier": "EXACT"}}, "description": "NTR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50189"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 111, "modifier": "EXACT"}, "end": {"value": 135, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022782"}], "id": "KW-0221", "category": "Biological process", "name": "Differentiation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022687"}], "id": "KW-0879", "category": "Biological process", "name": "Wnt signaling pathway"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EGAS7BV8JDS8L", "citationType": "submission", "authors": ["Mikhailov K.", "Kravchuk O.", "Lyupina Y.", "Adameyko K."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28597.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP971931", "properties": [{"key": "ProteinId", "value": "XCN28597.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042813", "properties": [{"key": "GoTerm", "value": "F:Wnt receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0017147", "properties": [{"key": "GoTerm", "value": "F:Wnt-protein binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0060070", "properties": [{"key": "GoTerm", "value": "P:canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030154", "properties": [{"key": "GoTerm", "value": "P:cell differentiation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0035567", "properties": [{"key": "GoTerm", "value": "P:non-canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd07066", "properties": [{"key": "EntryName", "value": "CRD_FZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.50.120", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.2000.10", "properties": [{"key": "EntryName", "value": "Frizzled cysteine-rich domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR015526", "properties": [{"key": "EntryName", "value": "Frizzled/SFRP"}]}, {"database": "InterPro", "id": "IPR020067", "properties": [{"key": "EntryName", "value": "Frizzled_dom"}]}, {"database": "InterPro", "id": "IPR036790", "properties": [{"key": "EntryName", "value": "Frizzled_dom_sf"}]}, {"database": "InterPro", "id": "IPR001134", "properties": [{"key": "EntryName", "value": "Netrin_domain"}]}, {"database": "InterPro", "id": "IPR018933", "properties": [{"key": "EntryName", "value": "Netrin_module_non-TIMP"}]}, {"database": "InterPro", "id": "IPR008993", "properties": [{"key": "EntryName", "value": "TIMP-like_OB-fold"}]}, {"database": "PANTHER", "id": "PTHR11309", "properties": [{"key": "EntryName", "value": "FRIZZLED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01392", "properties": [{"key": "EntryName", "value": "Fz"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01759", "properties": [{"key": "EntryName", "value": "NTR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00063", "properties": [{"key": "EntryName", "value": "FRI"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63501", "properties": [{"key": "EntryName", "value": "Frizzled cysteine-rich domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50242", "properties": [{"key": "EntryName", "value": "TIMP-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50038", "properties": [{"key": "EntryName", "value": "FZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50189", "properties": [{"key": "EntryName", "value": "NTR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRSSILLLVGTFLSVSFSMPVKRTIFGPQCYEMESPFCADAQMFPPGVRMNTTVSVSDRADTEATLNSFSHLIDMECAAELKKFLCFAYYPMCLHDQTGESHEIKPCRSSCETVRSKCELFVVAAGQSWPRSLDCAALPEAPLCMPVDAPAPGEQEAEATKCEECQVESKPSAVVQEICESHSSKLFVKARILTEEVVGDAKSLLYNVQVEQVISTKSASVAPKAHSNIWVITSSREDCNCHSLRSHESYLLALQAHTYGDTVFYILNGDAVVSEWSAVKDIQKQMESCSQQ", "length": 292, "molWeight": 32204, "crc64": "60C3B4F5A38448CC", "md5": "B919F2F371CFCF5D2555C540B3BFEC5F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2, "Disulfide bond": 1}, "uniParcId": "UPI0035D39C35"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N6G5", "uniProtkbId": "A0AAN0N6G5_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65884.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65884.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65884.1"}], "value": "UGT"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009995"}], "value": "Belongs to the UDP-glycosyltransferase family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65884.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145337", "properties": [{"key": "ProteinId", "value": "WRV65884.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050271", "properties": [{"key": "EntryName", "value": "UDP-glycosyltransferase"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48043", "properties": [{"key": "EntryName", "value": "EG:EG0003.4 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48043:SF145", "properties": [{"key": "EntryName", "value": "FI06409P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00201", "properties": [{"key": "EntryName", "value": "UDPGT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLNFLYFCQLEFGHLNVGLTLNSFFNKFYKDQVNIHFLVDDYWHERLLKIDPTIKTLILKSNEEKRENEKTEFDVLVESFTKCNSIEEQINNILPIANEFFISSYKYLQEIQKPVENLLKENNFNLLLVDSIIPVPYFFNKNIPYVSIVSMCILAIGRYDLPPSLSGTRIDQKHLWPKRIKMMEETYKDFVDLHNKYFENEKVDLRLKPGTFQLESPDLNIYLCPEEISYITNDLRDAIKKPHTVQLNGKWLRLDSPVMNEEKIKPYMLPENFSKSPGKLIYFSLGSNFSSNIYLMQKILDVLGEIPHKFIISKGKNGDKLKLPENCFGENFLPQKSVLKIIDLIITHGGNNTLTECFHFGVPMIVLPLFVDQLDNAERIVETEYGYKLDIFKKDYEGLKKTIEDALRNEKLKQKMNKASIRIQKNNGLEIICEELIKLSKKKKSL", "length": 446, "molWeight": 52177, "crc64": "4E1E9CB090936B1E", "md5": "A4DA667E6A9B0405F1A480F2EA63D1F0"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0032506A07"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN30", "uniProtkbId": "A0AA96MN30_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50093.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50093.1"}], "value": "Uncharacterized protein 22"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 110, "modifier": "EXACT"}, "end": {"value": 133, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 140, "modifier": "EXACT"}, "end": {"value": 162, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 198, "modifier": "EXACT"}, "end": {"value": 215, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 235, "modifier": "EXACT"}, "end": {"value": 259, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 279, "modifier": "EXACT"}, "end": {"value": 297, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 317, "modifier": "EXACT"}, "end": {"value": 356, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 325, "modifier": "EXACT"}, "end": {"value": 336, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50093.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460170", "properties": [{"key": "ProteinId", "value": "WNS50093.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNTSAGNLNLQAPFASVLGVQGYTAIVSVLLAVLVPLQVFLSVLTIMGLSVGRTFRKVKAQRNVLIAIASMGFVSSAILISFGIAEYLFLSGYVQAGIVFCHGGTLFYHIYAGMSNYLLACLSVTVLIIIRYGKHKIRRLYLNIALVVMSAIVFVLGFLHFFPSAISFAFQFDGVICFPNPSEAGYAGTGLALALVDIPSRVVSIGVAIASLCIVKKYTNLENKQLKIALLKFTVLLVVLNIAAFLANYISLIPFLLLFSFKDHLDFASLAVFRQLADFLLPSIPSILTPLMMIAVFRPLRAAIRKLILPSGWRAHSGGEEEEAAGERVPGDKKCENVSGEDQTESTALDYRGLQH", "length": 356, "molWeight": 38658, "crc64": "93B729650189E0A0", "md5": "D74541F85B9342CE5F3FE58F5659ED62"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 7, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B28CAA7"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PAV7", "uniProtkbId": "A0AAU6PAV7_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20556.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU610713"}], "value": "Hyaluronidase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU610713"}], "value": "3.2.1.35"}]}, "flag": "Fragment"}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.", "ecNumber": "3.2.1.35", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU610713"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008871"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU610713"}], "value": "Belongs to the glycosyl hydrolase 56 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 192, "modifier": "EXACT"}}, "description": "Hyaluronidase", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043873462"}, {"type": "Non-terminal residue", "location": {"start": {"value": 192, "modifier": "EXACT"}, "end": {"value": 192, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20556.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU610713"}], "id": "KW-0326", "category": "Molecular function", "name": "Glycosidase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU610713"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20556.1"}], "value": "U_LCTX_62_Cm24", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20556.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480825", "properties": [{"key": "ProteinId", "value": "WXB20556.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004415", "properties": [{"key": "GoTerm", "value": "F:hyalurononglucosaminidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006952", "properties": [{"key": "GoTerm", "value": "P:defense response"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0030214", "properties": [{"key": "GoTerm", "value": "P:hyaluronan catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "3.20.20.70", "properties": [{"key": "EntryName", "value": "Aldolase class I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR013785", "properties": [{"key": "EntryName", "value": "Aldolase_TIM"}]}, {"database": "InterPro", "id": "IPR017853", "properties": [{"key": "EntryName", "value": "Glycoside_hydrolase_SF"}]}, {"database": "InterPro", "id": "IPR018155", "properties": [{"key": "EntryName", "value": "Hyaluronidase"}]}, {"database": "InterPro", "id": "IPR001329", "properties": [{"key": "EntryName", "value": "Venom_Hyaluronidase"}]}, {"database": "PANTHER", "id": "PTHR11769", "properties": [{"key": "EntryName", "value": "HYALURONIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11769:SF35", "properties": [{"key": "EntryName", "value": "HYALURONIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01630", "properties": [{"key": "EntryName", "value": "Glyco_hydro_56"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00846", "properties": [{"key": "EntryName", "value": "GLHYDRLASE56"}]}, {"database": "PRINTS", "id": "PR00847", "properties": [{"key": "EntryName", "value": "HYALURONDASE"}]}, {"database": "SUPFAM", "id": "SSF51445", "properties": [{"key": "EntryName", "value": "(Trans)glycosidases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFHLFIMFFVSSVVKCDESSKDRLLGMPENESSFQVYWNVPTIQCQKKNIPFQDLYEKYGIKQNSGDSFRGEVISIMYDPGAFPALLKKGSNGKFEFRNGGVPQEGDLDVHMDAFKKELNRLIPDRNFNGLGVIDFESWRPVFRQNNGVLVPYREVSREIEKTRHSWWPEERLQNEARERFEAAGREFMEAT", "length": 192, "molWeight": 22429, "crc64": "68871904A5D8F55A", "md5": "ADAEE388E213ABB8DF39FF9310920A10"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D38C36"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P6S9", "uniProtkbId": "A0AAF0P6S9_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenuipotamon purpura", "taxonId": 2875585, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59162.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59162.1"}], "value": "Protein C144450940"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59162.1"}], "value": "C144450940"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006991"}], "value": "Belongs to the krueppel C2H2-type zinc-finger protein family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 45, "modifier": "EXACT"}, "end": {"value": 72, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 73, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 101, "modifier": "EXACT"}, "end": {"value": 129, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 137, "modifier": "EXACT"}, "end": {"value": 159, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 164, "modifier": "EXACT"}, "end": {"value": 192, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 202, "modifier": "EXACT"}, "end": {"value": 228, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 229, "modifier": "EXACT"}, "end": {"value": 256, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 259, "modifier": "EXACT"}, "end": {"value": 286, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 287, "modifier": "EXACT"}, "end": {"value": 314, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59162.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 318, "modifier": "EXACT"}, "end": {"value": 318, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59162.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00042"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59162.1"}], "value": "XDZL02", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59162.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59162.1"}], "value": "XDZL02", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59162.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515285", "properties": [{"key": "ProteinId", "value": "WMS59162.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003690", "properties": [{"key": "GoTerm", "value": "F:double-stranded DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0010468", "properties": [{"key": "GoTerm", "value": "P:regulation of gene expression"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:001370", "properties": [{"key": "EntryName", "value": "Zinc finger protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000264", "properties": [{"key": "EntryName", "value": "Zinc finger protein 236"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:001498", "properties": [{"key": "EntryName", "value": "Zinc finger protein 404"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000624", "properties": [{"key": "EntryName", "value": "zinc finger protein 697"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.160.60", "properties": [{"key": "EntryName", "value": "Classic Zinc Finger"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "InterPro", "id": "IPR050331", "properties": [{"key": "EntryName", "value": "Zinc_finger"}]}, {"database": "InterPro", "id": "IPR036236", "properties": [{"key": "EntryName", "value": "Znf_C2H2_sf"}]}, {"database": "InterPro", "id": "IPR013087", "properties": [{"key": "EntryName", "value": "Znf_C2H2_type"}]}, {"database": "PANTHER", "id": "PTHR16515:SF66", "properties": [{"key": "EntryName", "value": "C2H2-TYPE DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR16515", "properties": [{"key": "EntryName", "value": "PR DOMAIN ZINC FINGER PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00096", "properties": [{"key": "EntryName", "value": "zf-C2H2"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "Pfam", "id": "PF13912", "properties": [{"key": "EntryName", "value": "zf-C2H2_6"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SMART", "id": "SM00355", "properties": [{"key": "EntryName", "value": "ZnF_C2H2"}, {"key": "MatchStatus", "value": "10"}]}, {"database": "SUPFAM", "id": "SSF57667", "properties": [{"key": "EntryName", "value": "beta-beta-alpha zinc fingers"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "PROSITE", "id": "PS00028", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_1"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "PROSITE", "id": "PS50157", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_2"}, {"key": "MatchStatus", "value": "9"}]}], "sequence": {"value": "KRHAKIKHMKTHTMDDLKCLICNRTYPNRYSWSQHQLFHMGLVLFECKECGRRFQRKSELEVHMRTHTGERPYSCASCKSAFTTRQALKRHLVTHMDGQEVDCDVCHKTYKNIVCLNKHRLKAHSKNKGKAKVRRDYMCSTCNEVFPSSKKLAWHRETHERWPKKCQHCGECFVHQSSLTKHIRHKHDPHHQTPDGKTENNATCPVCRKVFKKSSLVLHLRTHTGVKPFQCNICNRSFAVKCNLEAHKWVHMGVRDRPHKCKLCERSFHRQKDLDAHIRSHKNIRPFTCNECGKSFIHKNNLQLHVREHSGEKQHKCM", "length": 318, "molWeight": 37617, "crc64": "95C3CD02C97B333E", "md5": "D2F5708080459E5DEEAEF1A02C2ECCD4"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 9, "Non-terminal residue": 2}, "uniParcId": "UPI002B289D37"}, "cluster_size": 13, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S1Q3", "uniProtkbId": "A0AA96S1Q3_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50046.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50046.1"}], "value": "Uncharacterized protein 6"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 559, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041712768"}, {"type": "Transmembrane", "location": {"start": {"value": 472, "modifier": "EXACT"}, "end": {"value": 496, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 124, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50046.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460123", "properties": [{"key": "ProteinId", "value": "WNS50046.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036116", "properties": [{"key": "EntryName", "value": "FN3_sf"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR003598", "properties": [{"key": "EntryName", "value": "Ig_sub2"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00408", "properties": [{"key": "EntryName", "value": "IGc2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49265", "properties": [{"key": "EntryName", "value": "Fibronectin type III"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVLPASILMLALATLTGCTEAETPDNITVVVDGYDYNSALESPAMVEIGSAFVLECTVAGLPRHSAVLYNWTHPRSAALVARYNNVVPGDANRRTLRVSVIDEGDAGLYQCIATIADRPARVLTGAFQVAVKGGAVLLSNHGAIPKNTAITDSWGIQPKYRFLHVSAFNISTIFCLAPKNSSPYFVRIANNSRENYIEERLGDAAGSGMPQDLLKQWKNQRAALLLIRDTNNVENMKICCMTGTARVCAYLWLQTPTALDTQEHDLNITLETDTILKIEKKLDRKTKKGVSSTYLATLQNSMTGLARTFVTKRSSLNMGSLFPGAAYKVSVREYWNENGTMQYSPTSNHLNISTKALQVNNATKESPPRMVTVSRVLVGGFELHWLPPRRFTPTHYTVHCTANGTNVTRYTVPHQPGSNYGNVTGLPAGECHTEVAAYLGATKVSSHRYTYSYEPKKSAGIKNDPGFNSLSVTLPVIAIFAVLLIVVIAVLIASQIKTFRTKKRQRREKKRKSASPEAPVEEDVYEKFNWSNVTPGLPGSGVMQNQYISTAPHSSTHHM", "length": 559, "molWeight": 61369, "crc64": "A8291B0A41571088", "md5": "50273DC348462935F2E0EA6CEC119337"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 1}, "uniParcId": "UPI002B322B1E"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHX2", "uniProtkbId": "A0AAN0LHX2_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34065.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34065.1"}], "value": "G protein-coupled receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 57, "modifier": "EXACT"}, "end": {"value": 81, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 93, "modifier": "EXACT"}, "end": {"value": 117, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 129, "modifier": "EXACT"}, "end": {"value": 154, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 175, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 214, "modifier": "EXACT"}, "end": {"value": 243, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 483, "modifier": "EXACT"}, "end": {"value": 504, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 524, "modifier": "EXACT"}, "end": {"value": 545, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 542, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34065.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154991", "properties": [{"key": "ProteinId", "value": "WRW34065.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008188", "properties": [{"key": "GoTerm", "value": "F:neuropeptide receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24238:SF75", "properties": [{"key": "EntryName", "value": "CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24238", "properties": [{"key": "EntryName", "value": "G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDNYFGENKEDNFINMLTYNIQNVNLSNVVFDSGGNTNSSSRNIYNSQISGLSLFTMVAPFTVIFVLAITGNLSVIATLAINRRMRTVTNAFLLNLAVADLLLGIFCMPFTLSGFIMKQFIFGSLMCRLIPYLQAVSVSVSSWTLVTMSVERYYAICQPLKSKSYRQNWAHVHKVIGCVWIFSLIIMSPIAYLSELKPMVEKDKYKCRENWPSHQYLIMFTLFLDILLLLIPLVIMIVTYTLIAISLTKIMSRDVATDQARNRTTSIDDTYNTATNKKDYNDCIINYQEKENGLVSRKNSCRSDIINDYSNQLNTKNRSISPIFKNNSSNQSSVKRPKTITFNYDSKKINSSSDKINKQESISLNDSKFCDNYFDNKDKEKCCEEIISLNKDIQFDIDYQSKIKQNDKNNNQEKLCKAIGPVNSNSQISNLNNSSLYISNSQHISKNENNQCSQQIQFNYKNCEPKLRSSVDRRLVQKRQSRVIKMLVMVVLEFFICWTPLHVINLISLYKPKIVYQAIGYDGLSLIHLLAYFSSCTNPITYCFMNSKLRQSFLSLFGCKSVKNKKYNTKILQSKYQTTIVKEL", "length": 584, "molWeight": 67088, "crc64": "E6C6B58AB6AAED90", "md5": "6940767153D347E374CBD260EDCE44A3"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI003252E2AE"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6S4A1", "uniProtkbId": "A0AAU6S4A1_IPSTY", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Ips typographus", "commonName": "European spruce bark beetle", "taxonId": 55986, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZI48998.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Coleoptera", "Polyphaga", "Cucujiformia", "Curculionidae", "Scolytinae", "Ips"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZI48998.1"}], "value": "OR45"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 129, "modifier": "EXACT"}, "end": {"value": 148, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 198, "modifier": "EXACT"}, "end": {"value": 222, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 278, "modifier": "EXACT"}, "end": {"value": 299, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 311, "modifier": "EXACT"}, "end": {"value": 331, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AA48G6LC0QKOV", "citationType": "submission", "authors": ["Biswas T.", "Sims C.", "Yuvaraj J.K.", "Roberts R.E.", "Lofstedt C.", "Andersson M.N."], "title": "Functional characterization supports multiple evolutionary origins of pheromone receptors bark beetles.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZI48998.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR987889", "properties": [{"key": "ProteinId", "value": "WZI48998.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MANQSNEQLISGVKKIMICTGVWRQPISTNATLNHLYLAYCKLMLIGRIILWFLLTGELVRLVLARYPNHVIIESLAVVITNWRMNLKFIVYEKTKIFQIFEVIVLKEREVWESRDVEKTRKYSKKVNFMQFGVLAMLITDSLTVLLMEGMGMAGTLNIKNHNQANNDTLESHMTLQVLLPLNRMNHLEWFFSTQLFWAWNAFTCNLSSLLIYVNILVYSVVQLEMLQIKFRNFVEPNFSLDAFTIEVQSKGAMLKKLIREHQHIIRFIKDFNNKMKYITMMEFIFSSLDMASVSISVIKVSSGSFFLNGIVGWQCFYVSLLITQLFLIGWTCNEVKVQSEAIGDAIFQSRWYLLNKDAKILVAMAIARSRRHLEMTVGPFGPMTTNSIVLILKAAYSYVNIMRT", "length": 405, "molWeight": 46871, "crc64": "DC8F32608C1D9269", "md5": "181F1DCD98450567E573BA9B1E1F820A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 5}, "uniParcId": "UPI0035D32028"}, "cluster_size": 1, "family": "Curculionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HDN0", "uniProtkbId": "A0AA96HDN0_9MOLL", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Spathoderma californicum", "taxonId": 3246909, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25269.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Aplacophora", "Caudofoveata", "Chaetodermatida", "Prochaetodermatidae", "Spathoderma"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25269.1"}], "value": "Hypoxia-inducible factor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 8, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Domain", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 240, "modifier": "EXACT"}, "end": {"value": 291, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 464, "modifier": "EXACT"}, "end": {"value": 494, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 464, "modifier": "EXACT"}, "end": {"value": 481, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25269.1"}], "value": "Prochaet1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25269.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ355004", "properties": [{"key": "ProteinId", "value": "WNN25269.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005667", "properties": [{"key": "GoTerm", "value": "C:transcription regulator complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd11433", "properties": [{"key": "EntryName", "value": "bHLH-PAS_HIF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR014887", "properties": [{"key": "EntryName", "value": "HIF-1_CTAD"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR001067", "properties": [{"key": "EntryName", "value": "Nuc_translocat"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "InterPro", "id": "IPR013655", "properties": [{"key": "EntryName", "value": "PAS_fold_3"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23171", "properties": [{"key": "EntryName", "value": "bHLH_HIF1A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08778", "properties": [{"key": "EntryName", "value": "HIF-1a_CTAD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08447", "properties": [{"key": "EntryName", "value": "PAS_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00785", "properties": [{"key": "EntryName", "value": "NCTRNSLOCATR"}]}, {"database": "SMART", "id": "SM00353", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MPYKNSEKRKEKSRDAARSRRGKETEIYYQLSKQLPLPHGISAKLDKATITRLTISYLKIWKIFVETSKNSKKVSQTSRDADIEQLYPKALEGFCVIISQDGDIIYLSDTVAKYLGIQQIELMGHSVYDFSHPCDHDEIKDVLSMKAIKHKHYSADRVFFVRMKCTLTSKGRNINLKSASYKVIKFRGHLTMMQKPIIELPLEHDLVENFTYLVAIGETIPHPSNIEVPLDSKTFLSKHNMDMKFVYCDERIRDLIGYHPEELIGNSFYIYPHALDSEVVTKAFKNLFAKGQTMTEQYRLLAKCGGYVFVVTQATIIYNVRTQKAQCVVCVHFVLSEIEKPKEILAEAQLPTTTFLKSTESVFVPMDKMMNKDYYFPPGIESRTYADGTLDLTHLAPSAGGEPVALLLDQFEGKVSPVMDPQFPQSYPEKLSPVMSPDLPITIFKEEPGLDVPNRCCRQLCSFSSTSNSGSSTPNSGSLSPQDYNSPGVGDSELMDRFSQLQPPTKHHGSSPFNENLDDGVDWEARAPFIPPMTDDQSLGHLMPITEPLFNLPTELNSDIFFNTENVFVPKSVLKDSRHHDSMRDMLLARNATSSMEQPRPIMAHQIKRSLDMSALEKGPPVTKKYISSREKMKRDEAASIDAQNLQKSVLMNLLLTGEDHNHGYSMMNNRPDIMYPDKSLLRIANPSADAQTTTSVWTQAYQQNLLPCITALDCEVNAPIQKSRLLQGADLLHALDGMSSNAHDNFNVG", "length": 750, "molWeight": 84546, "crc64": "7F4B586F84DE4AF4", "md5": "DF2BCBEDE51CAA7B5AD34929446204CD"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 2, "Compositional bias": 1}, "uniParcId": "UPI002B324B0A"}, "cluster_size": 3, "family": "Prochaetodermatidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S103", "uniProtkbId": "A0AA96S103_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50102.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50102.1"}], "value": "Uncharacterized protein 27"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 270, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041676111"}, {"type": "Region", "location": {"start": {"value": 97, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 105, "modifier": "EXACT"}, "end": {"value": 114, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50102.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460179", "properties": [{"key": "ProteinId", "value": "WNS50102.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MNAPSVTWIAVHVFAFWATLAVSATTVGQARRTDSESSSALETALDEAAQSLESQSINNQIEGPNKWNVEQKVGRNGGDGILGQMLDYVDRHSDHHTSAVSKAVKMKEKNKNDQDSSNFATLHNTQSSLKSIAQNDKYLKVKKIAAAVKAKLLRIAKKKLKKIKTKKNKKMKKKMVKKKKHRKPLTIVDLIDAQRVLGHYHGSLQALYNIYYRVYTSLKAKYLRLRFKCNKIRRKQRKKSRWSGILKKRFRRNRFKPSSHRRFRLRRSRG", "length": 270, "molWeight": 31143, "crc64": "0C591EEECF424FBF", "md5": "427C2F5E508D77A2DF1C125B23A02EE0"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B29990A"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEM0", "uniProtkbId": "A0AB38ZEM0_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02727.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02727.1"}], "value": "Venom peptide Os3a"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 62, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044192539"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02727.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517477", "properties": [{"key": "ProteinId", "value": "WXI02727.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MHLFKWISFLFVLIATVWAAPTDDDELFKPLSFLPGSNGRKVIELVKLCPEGQELNDKNQCV", "length": 62, "molWeight": 7063, "crc64": "127F77270D7E3F96", "md5": "2671E2A2ECB11DB9DCF497D76555A26B"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388C217B"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXT3", "uniProtkbId": "TX2B_POGRU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Pogonomyrmex rugosus", "commonName": "Desert harvester ant", "taxonId": 144042, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Hymenoptera", "Apocrita", "Aculeata", "Formicoidea", "Formicidae", "Myrmicinae", "Pogonomyrmex"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38110035"}], "value": "Myrmicitoxin(1)-Pr2b"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38110035"}], "value": "MYRTX(1)-Pr2b"}]}, "flag": "Fragment,Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "A0A8U0LTF0"}, {"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P0DRD0"}, {"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "P0DX61"}], "value": "Vertebrate-selective toxin that causes pain by targeting voltage-gated sodium channels"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "38110035"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "38110035"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the formicidae venom clade 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Propeptide", "location": {"start": {"value": 1, "modifier": "OUTSIDE"}, "end": {"value": 34, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "38110035"}], "featureId": "PRO_0000461245"}, {"type": "Peptide", "location": {"start": {"value": 35, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "Myrmicitoxin(1)-Pr2b", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "38110035"}], "featureId": "PRO_0000461246"}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 10, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 11, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Modified residue", "location": {"start": {"value": 61, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "Asparagine amide", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "38110035"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": ""}], "keywords": [{"id": "KW-0027", "category": "PTM", "name": "Amidation"}, {"id": "KW-0872", "category": "Molecular function", "name": "Ion channel impairing toxin"}, {"id": "KW-0528", "category": "Molecular function", "name": "Neurotoxin"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}, {"id": "KW-0738", "category": "Molecular function", "name": "Voltage-gated sodium channel impairing toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "38110035", "citationType": "journal article", "authors": ["Robinson S.D.", "Deuis J.R.", "Niu P.", "Touchard A.", "Mueller A.", "Schendel V.", "Brinkwirth N.", "King G.F.", "Vetter I.", "Schmidt J.O."], "citationCrossReferences": [{"database": "PubMed", "id": "38110035"}, {"database": "DOI", "id": "10.1016/j.jbc.2023.105577"}], "title": "Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants.", "publicationDate": "2024", "journal": "J. Biol. Chem.", "firstPage": "105577", "lastPage": "105577", "volume": "300"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "PROBABLE AMIDATION AT ASN-61"], "referenceComments": [{"value": "Venom gland", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR128475", "properties": [{"key": "ProteinId", "value": "WMI02513.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0017080", "properties": [{"key": "GoTerm", "value": "F:sodium channel regulator activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "NPWADPEAEANPEAKATAEATAEAIAEALAEPEPALPALPLLAFLFSLPAVQHWVEKNWING", "length": 62, "molWeight": 6603, "crc64": "939A1FBD9EBDFC5B", "md5": "EE56FCCFD1B532D241E8416E89EBE865"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Propeptide": 1, "Peptide": 1, "Region": 1, "Compositional bias": 2, "Modified residue": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00308AA9F2"}, "cluster_size": 1, "family": "Formicidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DRG0", "uniProtkbId": "CRY15_TITOB", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Tityus obscurus", "commonName": "Amazonian scorpion", "synonyms": ["Tityus cambridgei"], "taxonId": 1221240, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Scorpiones", "Buthida", "Buthoidea", "Buthidae", "Tityus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "28918200"}], "value": "Cryptide Pep-15"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "28918200"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}, {"commentType": "MASS SPECTROMETRY", "method": "Electrospray", "molWeight": 1510.71, "molWeightError": 0.0, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}]}], "features": [{"type": "Peptide", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 13, "modifier": "EXACT"}}, "description": "Cryptide Pep-15", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}], "featureId": "PRO_0000461750"}], "keywords": [{"id": "KW-0903", "category": "Technical term", "name": "Direct protein sequencing"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}], "references": [{"referenceNumber": 1, "citation": {"id": "28918200", "citationType": "journal article", "authors": ["Dias N.B.", "de Souza B.M.", "Cocchi F.K.", "Chalkidis H.M.", "Dorce V.A.C.", "Palma M.S."], "citationCrossReferences": [{"database": "PubMed", "id": "28918200"}, {"database": "DOI", "id": "10.1016/j.jprot.2017.09.006"}], "title": "Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.", "publicationDate": "2018", "journal": "J. Proteomics", "firstPage": "70", "lastPage": "79", "volume": "170"}, "referencePositions": ["PROTEIN SEQUENCE", "IDENTIFICATION BY MASS SPECTROMETRY", "MASS SPECTROMETRY", "SUBCELLULAR LOCATION"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}], "sequence": {"value": "RPPHNPGFLTVYN", "length": 13, "molWeight": 1512, "crc64": "38F66F84F0B3C867", "md5": "521FCB960DE2447759FC181E1250438D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "MASS SPECTROMETRY": 1}, "countByFeatureType": {"Peptide": 1}, "uniParcId": "UPI00388C3398"}, "cluster_size": 1, "family": "Buthidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QKZ6", "uniProtkbId": "A0AAU0QKZ6_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56492.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56492.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 100, "modifier": "EXACT"}, "end": {"value": 132, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 179, "modifier": "EXACT"}, "end": {"value": 203, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56492.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 204, "modifier": "EXACT"}, "end": {"value": 204, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56492.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56492.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56492.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56492.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970385", "properties": [{"key": "ProteinId", "value": "WPO56492.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "ILKSCFFHKDHGKWESIIDYISSVEIKEKCDGDKETNGIIIGYINRSRRVTYFFWSLAFFSNFSIFTEPYQKNQINVNGTNEYVHMFNGYVPYSQEPPGYYFSMFIQTVLGNIVSAYVVGWDTLVCTIMIFFNGQLKIMRLLCANIIDTENDNKSHYNIIECHRFYVTLVKKQKLFNSLISPAMFVYLIVISVNLGVCIIQIVQ", "length": 204, "molWeight": 23750, "crc64": "BD21268242569BF7", "md5": "85EB1C17BD019778E4E66E3F978B02E5"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 2}, "uniParcId": "UPI00308809AB"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96SLR0", "uniProtkbId": "A0AA96SLR0_PAELC", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia lactiflora", "commonName": "Chinese peony", "synonyms": ["Paeonia albiflora"], "taxonId": 35924, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94114.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94114.1"}], "value": "Uncharacterized protein"}}]}, "references": [{"referenceNumber": 1, "citation": {"id": "CI-816JBB05UD0I7", "citationType": "submission", "authors": ["Shi Y.J."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94114.1"}], "value": "S-CPA B", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94114.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR552627", "properties": [{"key": "ProteinId", "value": "WNT94114.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR004252", "properties": [{"key": "EntryName", "value": "Probable_transposase_24"}]}, {"database": "Pfam", "id": "PF03004", "properties": [{"key": "EntryName", "value": "Transposase_24"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEVDMGITPTRGDLFIKTHTRADNSPSEPTSEIFINEMKKLEALQAGESTMSNSISDLVYYKFFSKECHGHVRGCGPGVKKRDIGTSSSTGQVNGCTVAEIESLNLHIEQMKQRDMERDAEMDAMKHNLLEKDAKLEKMEKQMQTFICLLGDAPTSYMVSKLSFSWF", "length": 167, "molWeight": 18795, "crc64": "6B022C9652BD3FE3", "md5": "DC4C4E64C7301CB403095599FA1882FE"}, "extraAttributes": {"uniParcId": "UPI002B309A18"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA95NFV2", "uniProtkbId": "A0AA95NFV2_GINCI", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ginglymostoma cirratum", "commonName": "Nurse shark", "synonyms": ["Squalus cirratus"], "taxonId": 7801, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIV81743.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Chondrichthyes", "Elasmobranchii", "Galeomorphii", "Galeoidea", "Orectolobiformes", "Ginglymostomatidae", "Ginglymostoma"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIV81743.1"}], "value": "NKp30-like protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIV81743.1"}], "value": "NCR3H"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004251"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004251"}], "value": "Single-pass type I membrane protein", "id": "SL-9905"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 130, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIV81743.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 140, "modifier": "EXACT"}, "end": {"value": 140, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIV81743.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023319"}], "id": "KW-0393", "category": "Domain", "name": "Immunoglobulin domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "37735270", "citationType": "journal article", "authors": ["Janes M.E.", "Kinlein A.", "Flajnik M.F.", "Du Pasquier L.", "Ohta Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37735270"}], "title": "Genomic view of the origins of cell-mediated immunity.", "publicationDate": "2023", "journal": "Immunogenetics", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIV81743.1"}], "value": "Spleen", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIV81743.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR130455", "properties": [{"key": "ProteinId", "value": "WIV81743.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0009897", "properties": [{"key": "GoTerm", "value": "C:external side of plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007166", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071222", "properties": [{"key": "GoTerm", "value": "P:cellular response to lipopolysaccharide"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006955", "properties": [{"key": "GoTerm", "value": "P:immune response"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042130", "properties": [{"key": "GoTerm", "value": "P:negative regulation of T cell proliferation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042102", "properties": [{"key": "GoTerm", "value": "P:positive regulation of T cell proliferation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0031295", "properties": [{"key": "GoTerm", "value": "P:T cell costimulation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR013106", "properties": [{"key": "EntryName", "value": "Ig_V-set"}]}, {"database": "InterPro", "id": "IPR051713", "properties": [{"key": "EntryName", "value": "T-cell_Activation_Regulation"}]}, {"database": "PANTHER", "id": "PTHR25466:SF9", "properties": [{"key": "EntryName", "value": "FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR25466", "properties": [{"key": "EntryName", "value": "T-LYMPHOCYTE ACTIVATION ANTIGEN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07686", "properties": [{"key": "EntryName", "value": "V-set"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00406", "properties": [{"key": "EntryName", "value": "IGv"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "LLPFGNGIVSANTIESIGTKTTEATVAGGALAQPEQPSVNQGIAKLKAEKGKSVVLPCWYLNDGPSLNQVSVLWYKEDTSEKFNLVRDNTTGAGNYSGRVFLSGHLSNGDASLTILNVTERDDGTYFCTVILNNGTTLGG", "length": 140, "molWeight": 14752, "crc64": "8A5A2433FF488B85", "md5": "A303C8B1467A5142E95EF76C563BEC5B"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B27D566"}, "cluster_size": 1, "family": "Ginglymostomatidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTY2", "uniProtkbId": "A0AAT9UTY2_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41709.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41709.1"}], "value": "Cytochrome P450 4461N1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 38, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 457, "modifier": "EXACT"}, "end": {"value": 457, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41709.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117269", "properties": [{"key": "ProteinId", "value": "WIM41709.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNFHSTNQRDRETSTSKMNLVIFACVTIIITLLLRIYFKTKYKRFYKLIEQFPSHPTSPLIGNLKASYATVKDFRRNVMDLMKSHDRLIFWIGPIPILLLKRADDVSFILSQCDNREMHELGKQWAGVGVLTGSYEEWKKSRKLILPAFSAKMLSKYVETFITKSSNLVDRFKPMADTGEVVNISDHALTINIETMLENVLDVSPEEAGKAGEEFGHLTAKVFEFIIDRMLKPWLYPHCFYNLYLKLTGKMKLVEAFHYLPTKMLKERTAEFKARKEQSDFVDSPKTIINLIISENQREDTRFNEERLKGELLQMIAAGFETSSLSLSTILLMLALHQDAQEKVYEEILRDLQGETKITAHHVMNKFKYLEQCFRETVRMYSPIVLTLRQTYKEHVLRDNTIIPSGLCVVPLIHLAQRDGDLYENPDKWDPDHYSDEAILKRPKGKETAFGNGVRYCLGSKYVTFSIKSQVAHVILNYRLTSNIKELKPEDLRMDFSIRSAIGYPIIFHSRQKTAQM", "length": 517, "molWeight": 59950, "crc64": "75436B805C4694AC", "md5": "E6857A1543BE8AB422C8E92BC3532FD7"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D2741F"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DRF9", "uniProtkbId": "CRY14_TITOB", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tityus obscurus", "commonName": "Amazonian scorpion", "synonyms": ["Tityus cambridgei"], "taxonId": 1221240, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Scorpiones", "Buthida", "Buthoidea", "Buthidae", "Tityus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "28918200"}], "value": "Cryptide Pep-14"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "28918200"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}], "features": [{"type": "Peptide", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "Cryptide Pep-14", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "28918200"}], "featureId": "PRO_0000461749"}], "keywords": [{"id": "KW-0903", "category": "Technical term", "name": "Direct protein sequencing"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}], "references": [{"referenceNumber": 1, "citation": {"id": "28918200", "citationType": "journal article", "authors": ["Dias N.B.", "de Souza B.M.", "Cocchi F.K.", "Chalkidis H.M.", "Dorce V.A.C.", "Palma M.S."], "citationCrossReferences": [{"database": "PubMed", "id": "28918200"}, {"database": "DOI", "id": "10.1016/j.jprot.2017.09.006"}], "title": "Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.", "publicationDate": "2018", "journal": "J. Proteomics", "firstPage": "70", "lastPage": "79", "volume": "170"}, "referencePositions": ["PROTEIN SEQUENCE", "IDENTIFICATION BY MASS SPECTROMETRY", "SUBCELLULAR LOCATION"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}], "sequence": {"value": "VYWLPAVLGSLLGFTP", "length": 16, "molWeight": 1733, "crc64": "E26F77883918B087", "md5": "27202DB4D523421D94C2CBC86BD8DE3E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1}, "countByFeatureType": {"Peptide": 1}, "uniParcId": "UPI00388C33AA"}, "cluster_size": 1, "family": "Buthidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96SJD1", "uniProtkbId": "A0AA96SJD1_LYMDI", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Lymantria dispar", "commonName": "Gypsy moth", "synonyms": ["Porthetria dispar"], "taxonId": 13123, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94920.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Erebidae", "Lymantriinae", "Lymantria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94920.1"}], "value": "Ecdysone-inducible protein E74"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU004019"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005562"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU004019"}], "value": "Belongs to the ETS family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 319, "modifier": "EXACT"}, "end": {"value": 401, "modifier": "EXACT"}}, "description": "ETS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50061"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 94, "modifier": "EXACT"}, "end": {"value": 120, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 161, "modifier": "EXACT"}, "end": {"value": 212, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 287, "modifier": "EXACT"}, "end": {"value": 314, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 39, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 177, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 287, "modifier": "EXACT"}, "end": {"value": 299, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU004019"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU004019"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FQUKRKBTHH99F", "citationType": "submission", "authors": ["wang z.", "zou c."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT94920.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR474081", "properties": [{"key": "ProteinId", "value": "WNT94920.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0001228", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription activator activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0043565", "properties": [{"key": "GoTerm", "value": "F:sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006914", "properties": [{"key": "GoTerm", "value": "P:autophagy"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0030154", "properties": [{"key": "GoTerm", "value": "P:cell differentiation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0040034", "properties": [{"key": "GoTerm", "value": "P:regulation of development, heterochronic"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "1.10.10.10:FF:000411", "properties": [{"key": "EntryName", "value": "Ecdysone-induced protein 74EF isoform A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.10.10", "properties": [{"key": "EntryName", "value": "Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000418", "properties": [{"key": "EntryName", "value": "Ets_dom"}]}, {"database": "InterPro", "id": "IPR046328", "properties": [{"key": "EntryName", "value": "ETS_fam"}]}, {"database": "InterPro", "id": "IPR036388", "properties": [{"key": "EntryName", "value": "WH-like_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR036390", "properties": [{"key": "EntryName", "value": "WH_DNA-bd_sf"}]}, {"database": "PANTHER", "id": "PTHR11849:SF191", "properties": [{"key": "EntryName", "value": "ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11849", "properties": [{"key": "EntryName", "value": "ETS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00178", "properties": [{"key": "EntryName", "value": "Ets"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00454", "properties": [{"key": "EntryName", "value": "ETSDOMAIN"}]}, {"database": "SMART", "id": "SM00413", "properties": [{"key": "EntryName", "value": "ETS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF46785", "properties": [{"key": "EntryName", "value": "Winged helix' DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00345", "properties": [{"key": "EntryName", "value": "ETS_DOMAIN_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00346", "properties": [{"key": "EntryName", "value": "ETS_DOMAIN_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50061", "properties": [{"key": "EntryName", "value": "ETS_DOMAIN_3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MMAVEARPASAGPEPRRSPASDRRALSADEPRTLAARKAYPEESMSPKHEDDAPLDLTVRKEISVCDFARHSAFADPTDYMTTQIILKQSQEYLASGRDSGTESDDSAGRLSPGDDTVSGKAYKKSLMRRYIDGESTGLPLARSSLSRALLLLAPGPGPRHHLYSTPNTGSLPPSPADSGVSDVESSSSGAGSAEELKARLQPPPPAPFHAPFLPFYQHHQIANTLQHHATAHPRPPVGAVSERDAYAYGYGGGGGGAHHFAAPAPPPLPHDELPYPVFDFGDYQRHHHHNKLKPKKRPRTDAPPTPGVKRKSREGSTTYLWEFLLKLLQDREYCPRFIKWTNREKGVFKLVDSKAVSRLWGLHKNKPDMNYETMGRALRYYYQRGILAKVDGQRLVYQFVDVPKDIVEIDCSLA", "length": 415, "molWeight": 45875, "crc64": "4DC56E31EF15039E", "md5": "7844E620CCC331F2F43FA4A183233062"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Region": 4, "Compositional bias": 4}, "uniParcId": "UPI002B308FAC"}, "cluster_size": 4, "family": "Erebidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6SI50", "uniProtkbId": "A0AAU6SI50_9METZ", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucetta chagosensis", "taxonId": 185688, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZU99772.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Calcarea", "Calcinea", "Clathrinida", "Leucettidae", "Leucetta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00040165"}], "value": "X-box-binding protein 1"}}, "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZU99772.1"}], "value": "XBP1_1"}}], "features": [{"type": "Domain", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "BZIP", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50217"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 62, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 112, "modifier": "EXACT"}, "end": {"value": 134, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 8, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 45, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 120, "modifier": "EXACT"}, "end": {"value": 130, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZU99772.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 172, "modifier": "EXACT"}, "end": {"value": 172, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZU99772.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38952658", "citationType": "journal article", "authors": ["Posadas N.", "Conaco C."], "citationCrossReferences": [{"database": "PubMed", "id": "38952658"}], "title": "Gene networks governing the response of a calcareous sponge to future ocean conditions reveal lineage-specific XBP1 regulation of the unfolded protein response.", "publicationDate": "2024", "journal": "Ecol. Evol.", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZU99772.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-B6JVVS90CVM02", "citationType": "submission", "authors": ["Posadas N.", "Conaco C."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZU99772.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP716769", "properties": [{"key": "ProteinId", "value": "WZU99772.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.20.5.170", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR004827", "properties": [{"key": "EntryName", "value": "bZIP"}]}, {"database": "InterPro", "id": "IPR046347", "properties": [{"key": "EntryName", "value": "bZIP_sf"}]}, {"database": "InterPro", "id": "IPR052470", "properties": [{"key": "EntryName", "value": "ER_Stress-Reg_TF"}]}, {"database": "PANTHER", "id": "PTHR46542", "properties": [{"key": "EntryName", "value": "X-BOX BINDING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46542:SF1", "properties": [{"key": "EntryName", "value": "X-BOX BINDING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00170", "properties": [{"key": "EntryName", "value": "bZIP_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00338", "properties": [{"key": "EntryName", "value": "BRLZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57959", "properties": [{"key": "EntryName", "value": "Leucine zipper domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50217", "properties": [{"key": "EntryName", "value": "BZIP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "AIFKRNMLPLSPSSSSSSPSSPEVVEAPTRRKREKLDHLSFQEKRERRKLNNRVSAQHARDRKKSYLEDLERLVASLKAENTALKSTNASLSSSIQEVRRANESLRSQLCLTPPCSPVSSERKPEADARSESAALSVPLQQERLTVAKPWLLFCWITIMSALRSILEETLVQ", "length": 172, "molWeight": 19398, "crc64": "A29AC7D65ECED95A", "md5": "6FAA7C044D4E903000AAC1A0D16D4F9E"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 2, "Compositional bias": 3, "Non-terminal residue": 2}, "uniParcId": "UPI0035D2861B"}, "cluster_size": 1, "family": "Leucettidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UUX9", "uniProtkbId": "A0AAT9UUX9_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41708.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41708.1"}], "value": "Cytochrome P450 4461M1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 437, "modifier": "EXACT"}, "end": {"value": 437, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41708.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117268", "properties": [{"key": "ProteinId", "value": "WIM41708.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MITTLIFASVIAIFLARYLYKKKHARFYQLLQQFPSYTSYPIIGNLLMLKDHSGDFVQKLEKCLQPHDRLMFWLGTTPALLLKNYEDIMTVLSQCNSNDLSKFVKPWSGAAIATSRQETWKTSKKILVHAFTSEMLSKYANVFNKSAANLVDELKQVANTDQAIDVLNVLCVCSRNAIIENSLGSSLRNFGEENRFGESFQVVIEDIMKRIFTFWLHPQFVYSAYLRITGKIKIANHIHDLTSKVIRNKLNAYHRGTHKFDDGHPPETIVDVLVQKSFQETSMTEIRIRDEVLQIINAAVETSSITMSYLMLMLAMHQNIQQRVYEEIVQLMGDDATITADHSFNHLKYLEQCIKETCRMYSHVTLINRYTEKEHMLDDGKVIPAGIIVLPLARYAYKDPRLFANPQKWDPQHFSEEALAKRPKGSEMIFGYGPRTCLGQKYSLMSIKTQIAYILREYHLSTDIKEIKEKDFTVDFMVRSKFGYPIKFASRKKTEATL", "length": 498, "molWeight": 57512, "crc64": "164F85FA38CE7B8C", "md5": "18C1ABA8C1511EC9E1F36D2127061B49"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D3AFA3"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJF4", "uniProtkbId": "A0AAU7LJF4_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28206.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28206.1"}], "value": "MADS11"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28206.1"}], "value": "MADS11"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00054895"}], "value": "Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space"}], "commentType": "FUNCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00064368"}], "value": "Heterodimer of 2 subunits, IMP1A/B and IMP12"}], "commentType": "SUBUNIT"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004273"}], "value": "Mitochondrion inner membrane", "id": "SL-0168"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00038445"}], "value": "Belongs to the peptidase S26 family. IMP1 subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "Peptidase S26", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF10502"}]}, {"type": "Domain", "location": {"start": {"value": 128, "modifier": "EXACT"}, "end": {"value": 167, "modifier": "EXACT"}}, "description": "Peptidase S26", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF10502"}]}, {"type": "Active site", "location": {"start": {"value": 60, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR600223-1"}]}, {"type": "Active site", "location": {"start": {"value": 104, "modifier": "EXACT"}, "end": {"value": 104, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR600223-1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023128"}], "id": "KW-0496", "category": "Cellular component", "name": "Mitochondrion"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022792"}], "id": "KW-0999", "category": "Cellular component", "name": "Mitochondrion inner membrane"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28206.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28206.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400846", "properties": [{"key": "ProteinId", "value": "XBP28206.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0042720", "properties": [{"key": "GoTerm", "value": "C:mitochondrial inner membrane peptidase complex"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006627", "properties": [{"key": "GoTerm", "value": "P:protein processing involved in protein targeting to mitochondrion"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006465", "properties": [{"key": "GoTerm", "value": "P:signal peptide processing"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd06530", "properties": [{"key": "EntryName", "value": "S26_SPase_I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.10.109.10:FF:000014", "properties": [{"key": "EntryName", "value": "Inner membrane protease subunit 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.10.109.10", "properties": [{"key": "EntryName", "value": "Umud Fragment, subunit A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036286", "properties": [{"key": "EntryName", "value": "LexA/Signal_pep-like_sf"}]}, {"database": "InterPro", "id": "IPR052064", "properties": [{"key": "EntryName", "value": "Mito_IMP1_subunit"}]}, {"database": "InterPro", "id": "IPR000223", "properties": [{"key": "EntryName", "value": "Pept_S26A_signal_pept_1"}]}, {"database": "InterPro", "id": "IPR019533", "properties": [{"key": "EntryName", "value": "Peptidase_S26"}]}, {"database": "PANTHER", "id": "PTHR12383:SF30", "properties": [{"key": "EntryName", "value": "MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1-LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12383", "properties": [{"key": "EntryName", "value": "PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10502", "properties": [{"key": "EntryName", "value": "Peptidase_S26"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00727", "properties": [{"key": "EntryName", "value": "LEADERPTASE"}]}, {"database": "SUPFAM", "id": "SSF51306", "properties": [{"key": "EntryName", "value": "LexA/Signal peptidase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGLRNLSQLKNALRDFLSFTQKQGIFREVWDKSLLVIKFACAVHVTNTYVCTVVLTYGPSMLPTLSLTGDLLLAEKLSTQFGCVRPGDIVLVRSPVIPRRIVTKRLIGMEGDTITYIVDPGKSDRKETIVVPKGHVWVEGDNIYNSNDSRKFGVVSYGLLHSKVFWRVLASRGILIDLFFAVNCYLGSSGGYVEKSRLKLQWWQILDGSCYRLCKKQLQVLSAAKGSEGQCMDERQWRRLEMATVEVGTRTTFQIDPVFAPICLGVAICASGNHHRHFPSWRNEESHLRDVIHYLSPRVSLE", "length": 302, "molWeight": 34137, "crc64": "66159786E78202EE", "md5": "F79726CFF40D7722093441BA790F8F3D"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBUNIT": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2, "Active site": 2}, "uniParcId": "UPI0035D2FF9E"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2H4", "uniProtkbId": "A0AA96S2H4_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50103.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50103.1"}], "value": "Uncharacterized protein 28"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 135, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041687919"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50103.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460180", "properties": [{"key": "ProteinId", "value": "WNS50103.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MNRFLLLLGLFGLASVISAAPLEVKDSGKEEDNDAFHDDSDLLQMMADDNGDDDDDFDKLLVHLMTALDDDNDNSDALFAMNAATEDDDGDVDAEGWRGWPRNKRRRFNRRMQYLRRLRRLRRARKLRRRGHYWG", "length": 135, "molWeight": 15758, "crc64": "D12EEA0F5CE04F10", "md5": "7E96E3D9DFEEE17B1C0F840612073D54"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B28720C"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6NDM5", "uniProtkbId": "A0AAU6NDM5_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59789.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59789.1"}], "value": "OR20"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 75, "modifier": "EXACT"}, "end": {"value": 94, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 142, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59789.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59789.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420149", "properties": [{"key": "ProteinId", "value": "WWA59789.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "VLVKMADEEFEFKPFSVTYKLITFALSVGMIYPNPKTEKWRLASIPILVASIMPLALMIFYDMYKSWMVKDIVNIIRHSTVVGPFLGGFFKMILMYHKRIQAKEILDEIDRDHDLFNECADIYKDIARAAIKNSQVYSERGWAITVSTCVMTFPVMAIALNIYNFTFKSEPEKYMIHDLVIPETESELRFETPYFEVIYYYHYIV", "length": 205, "molWeight": 24095, "crc64": "26437A2E485E45ED", "md5": "B78D172A57F5F9E5F01B8270870068B7"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 4, "Non-terminal residue": 1}, "uniParcId": "UPI0035D399D5"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHN2", "uniProtkbId": "A0AAQ5BHN2_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519452.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519452.1"}], "value": "C-C motif chemokine ligand 21"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519452.1"}], "value": "CCL21"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 129, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042927830"}, {"type": "Domain", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "Chemokine interleukin-8-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00048"}]}, {"type": "Region", "location": {"start": {"value": 86, "modifier": "EXACT"}, "end": {"value": 129, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 86, "modifier": "EXACT"}, "end": {"value": 95, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 96, "modifier": "EXACT"}, "end": {"value": 106, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 117, "modifier": "EXACT"}, "end": {"value": 129, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022514"}], "id": "KW-0202", "category": "Molecular function", "name": "Cytokine"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHN2"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519452.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15164053", "citationType": "journal article", "authors": ["Humphray S.J.", "Oliver K.", "Hunt A.R.", "Plumb R.W.", "Loveland J.E.", "Howe K.L.", "Andrews T.D.", "Searle S.", "Hunt S.E.", "Scott C.E.", "Jones M.C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Ashwell R.I.", "Babbage A.K.", "Babbage S.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beasley H.", "Beasley O.", "Bird C.P.", "Bray-Allen S.", "Brown A.J.", "Brown J.Y.", "Burford D.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Chen Y.", "Clarke G.", "Clark S.Y.", "Clee C.M.", "Clegg S.", "Collier R.E.", "Corby N.", "Crosier M.", "Cummings A.T.", "Davies J.", "Dhami P.", "Dunn M.", "Dutta I.", "Dyer L.W.", "Earthrowl M.E.", "Faulkner L.", "Fleming C.J.", "Frankish A.", "Frankland J.A.", "French L.", "Fricker D.G.", "Garner P.", "Garnett J.", "Ghori J.", "Gilbert J.G.", "Glison C.", "Grafham D.V.", "Gribble S.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Guy J.", "Hall R.E.", "Hammond S.", "Harley J.L.", "Harrison E.S.", "Hart E.A.", "Heath P.D.", "Henderson C.D.", "Hopkins B.L.", "Howard P.J.", "Howden P.J.", "Huckle E.", "Johnson C.", "Johnson D.", "Joy A.A.", "Kay M.", "Keenan S.", "Kershaw J.K.", "Kimberley A.M.", "King A.", "Knights A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.", "Lloyd D.M.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "McLaren S.", "McLay K.E.", "McMurray A.", "Milne S.", "Nickerson T.", "Nisbett J.", "Nordsiek G.", "Pearce A.V.", "Peck A.I.", "Porter K.M.", "Pandian R.", "Pelan S.", "Phillimore B.", "Povey S.", "Ramsey Y.", "Rand V.", "Scharfe M.", "Sehra H.K.", "Shownkeen R.", "Sims S.K.", "Skuce C.D.", "Smith M.", "Steward C.A.", "Swarbreck D.", "Sycamore N.", "Tester J.", "Thorpe A.", "Tracey A.", "Tromans A.", "Thomas D.W.", "Wall M.", "Wallis J.M.", "West A.P.", "Whitehead S.L.", "Willey D.L.", "Williams S.A.", "Wilming L.", "Wray P.W.", "Young L.", "Ashurst J.L.", "Coulson A.", "Blocker H.", "Durbin R.", "Sulston J.E.", "Hubbard T.", "Jackson M.J.", "Bentley D.R.", "Beck S.", "Rogers J.", "Dunham I."], "citationCrossReferences": [{"database": "PubMed", "id": "15164053"}, {"database": "DOI", "id": "10.1038/nature02465"}], "title": "DNA sequence and analysis of human chromosome 9.", "publicationDate": "2004", "journal": "Nature", "firstPage": "369", "lastPage": "374", "volume": "429"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519452.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519452.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519452.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL162231", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHN2", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714163.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519452.1"}, {"key": "GeneId", "value": "ENSG00000137077.9"}]}, {"database": "HGNC", "id": "HGNC:10620", "properties": [{"key": "GeneName", "value": "CCL21"}]}, {"database": "OpenTargets", "id": "ENSG00000137077", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT01130000278316", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 9"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0008009", "properties": [{"key": "GoTerm", "value": "F:chemokine activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006955", "properties": [{"key": "GoTerm", "value": "P:immune response"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "2.40.50.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001811", "properties": [{"key": "EntryName", "value": "Chemokine_IL8-like_dom"}]}, {"database": "InterPro", "id": "IPR036048", "properties": [{"key": "EntryName", "value": "Interleukin_8-like_sf"}]}, {"database": "Pfam", "id": "PF00048", "properties": [{"key": "EntryName", "value": "IL8"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54117", "properties": [{"key": "EntryName", "value": "Interleukin 8-like chemokines"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILPHPQVLAPQALSGRAMCRPKGALGAAADAASGQDTIPTETSPGLQEGQGGLQDWQERKGLQRLQED", "length": 129, "molWeight": 13636, "crc64": "A2AA11C49AF0EC91", "md5": "11C6E8E156219BB90492784CB682201F"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 3}, "uniParcId": "UPI0032C5AFD2"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB34HF07", "uniProtkbId": "A0AB34HF07_ESCRO", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Eschrichtius robustus", "commonName": "California gray whale", "synonyms": ["Eschrichtius gibbosus"], "taxonId": 9764, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAJ8789808.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001159641"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Laurasiatheria", "Artiodactyla", "Whippomorpha", "Cetacea", "Mysticeti", "Eschrichtiidae", "Eschrichtius"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}], "value": "C2H2-type domain-containing protein"}}}, "genes": [{"orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAJ8789808.1"}], "value": "J1605_021766"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003767"}], "value": "May be involved in transcriptional regulation"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006991"}], "value": "Belongs to the krueppel C2H2-type zinc-finger protein family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAJ8789808.1"}], "value": "The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}], "commentType": "CAUTION"}], "features": [{"type": "Domain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 44, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 45, "modifier": "EXACT"}, "end": {"value": 72, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 73, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 101, "modifier": "EXACT"}, "end": {"value": 128, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 129, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 157, "modifier": "EXACT"}, "end": {"value": 184, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 185, "modifier": "EXACT"}, "end": {"value": 212, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 213, "modifier": "EXACT"}, "end": {"value": 240, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 241, "modifier": "EXACT"}, "end": {"value": 268, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 269, "modifier": "EXACT"}, "end": {"value": 296, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 297, "modifier": "EXACT"}, "end": {"value": 324, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 325, "modifier": "EXACT"}, "end": {"value": 352, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 353, "modifier": "EXACT"}, "end": {"value": 380, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 379, "modifier": "EXACT"}, "end": {"value": 399, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 400, "modifier": "EXACT"}, "end": {"value": 427, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 428, "modifier": "EXACT"}, "end": {"value": 451, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047216"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001159641"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00042"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3CM71FJ3J1TES", "citationType": "submission", "authors": ["Bruniche-Olsen A.", "Black A.N.", "Fields C.J.", "Walden K.", "Dewoody J.A."], "title": "Whole genome sequence of Eschrichtius robustus ER-17-0199.", "publicationDate": "NOV-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAJ8789808.1"}], "value": "ER-17-0199", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAJ8789808.1"}], "value": "Blubber", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAJ8789808.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001159641"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "JAIQCJ010001396", "properties": [{"key": "ProteinId", "value": "KAJ8789808.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP001159641", "properties": [{"key": "Component", "value": "Unassembled WGS sequence"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006357", "properties": [{"key": "GoTerm", "value": "P:regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000029", "properties": [{"key": "EntryName", "value": "GLI family zinc finger 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:002063", "properties": [{"key": "EntryName", "value": "RB associated KRAB zinc finger"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000139", "properties": [{"key": "EntryName", "value": "zinc finger protein 1 homolog"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000555", "properties": [{"key": "EntryName", "value": "Zinc finger protein 1 homolog"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000478", "properties": [{"key": "EntryName", "value": "Zinc finger protein 133"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000638", "properties": [{"key": "EntryName", "value": "Zinc finger protein 184"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:002343", "properties": [{"key": "EntryName", "value": "Zinc finger protein 33A"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000848", "properties": [{"key": "EntryName", "value": "Zinc finger protein 35"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:002797", "properties": [{"key": "EntryName", "value": "Zinc finger protein 613"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.160.60", "properties": [{"key": "EntryName", "value": "Classic Zinc Finger"}, {"key": "MatchStatus", "value": "16"}]}, {"database": "InterPro", "id": "IPR050589", "properties": [{"key": "EntryName", "value": "Ikaros_C2H2-ZF"}]}, {"database": "InterPro", "id": "IPR036236", "properties": [{"key": "EntryName", "value": "Znf_C2H2_sf"}]}, {"database": "InterPro", "id": "IPR013087", "properties": [{"key": "EntryName", "value": "Znf_C2H2_type"}]}, {"database": "PANTHER", "id": "PTHR24404", "properties": [{"key": "EntryName", "value": "ZINC FINGER PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24404:SF41", "properties": [{"key": "EntryName", "value": "ZINC FINGER PROTEIN 613"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00096", "properties": [{"key": "EntryName", "value": "zf-C2H2"}, {"key": "MatchStatus", "value": "14"}]}, {"database": "Pfam", "id": "PF13912", "properties": [{"key": "EntryName", "value": "zf-C2H2_6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00355", "properties": [{"key": "EntryName", "value": "ZnF_C2H2"}, {"key": "MatchStatus", "value": "15"}]}, {"database": "SUPFAM", "id": "SSF57667", "properties": [{"key": "EntryName", "value": "beta-beta-alpha zinc fingers"}, {"key": "MatchStatus", "value": "8"}]}, {"database": "PROSITE", "id": "PS00028", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_1"}, {"key": "MatchStatus", "value": "15"}]}, {"database": "PROSITE", "id": "PS50157", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_2"}, {"key": "MatchStatus", "value": "16"}]}], "sequence": {"value": "MSQLFDHQRVHTREKPHGCSLCGKAFSRKSRLTEHQRTHTGLKHYECTECDKTFFKKSQFNKHQKSHMGEKPYTCSECGKAFTTKCLLIYHQRTHTGEKPHGCSLCGKAFSTKFSLTTHQKTHTGEKPYICSECGKGFIEKRRLIAHRRTHTGEKPFVCSECGKSFTLKKSLIPHQRTHTGEKPYTCNDCGKGFTLKNPLIRHQRTHTGEKPYVCSVCGKGFTMKGDLVVHQRTHIAEKPFICSDCGKGFTVKSQLIVHERTHTGEKPYVCSECGKGFPAKARLIGHQRTHTGEKPYICSDCGKGFIQKGNLIVHQRTHTGEKPYVCNECGKGLSAKRKLIAHLRTHTGEKPYICSECGKGFTVKSTLGTHQQTHTGEKPYKCNDDLITHQRIHTGEKPYECSECGKTFTTKSGLSVHQRKHTGERPYGCSECGKAFAHLSILDKHKRIHR", "length": 451, "molWeight": 50996, "crc64": "F072D4C065AEC5A8", "md5": "431456CE5551F1617FC879B1433627D1"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Domain": 16}, "uniParcId": "UPI00246D7BA5"}, "cluster_size": 1, "family": "Eschrichtiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7BN79", "uniProtkbId": "A0AAU7BN79_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33917.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33917.1"}], "value": "Glycosyltransferase"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33917.1"}], "value": "ABO"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001936"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004606"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004606"}], "value": "Single-pass type II membrane protein", "id": "SL-9906"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010413"}], "value": "Belongs to the glycosyltransferase 6 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Active site", "location": {"start": {"value": 43, "modifier": "EXACT"}, "end": {"value": 43, "modifier": "EXACT"}}, "description": "Nucleophile", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR605076-1"}]}, {"type": "Binding site", "location": {"start": {"value": 43, "modifier": "EXACT"}, "end": {"value": 43, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:140327"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR605076-2"}], "ligand": {"name": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative", "id": "ChEBI:CHEBI:140327"}}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33917.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 60, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33917.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022968"}], "id": "KW-0735", "category": "Domain", "name": "Signal-anchor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022968"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-D2446FVSI6Q1B", "citationType": "submission", "authors": ["Zhong J.", "Gao Y.M.", "Mo C.P.", "Zhang Y.", "Li L.B.", "Wei S.T.", "Li T.Y."], "publicationDate": "MAY-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBG33917.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP834546", "properties": [{"key": "ProteinId", "value": "XBG33917.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "PeptideAtlas", "id": "A0AAU7BN79", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.90.550.10", "properties": [{"key": "EntryName", "value": "Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005076", "properties": [{"key": "EntryName", "value": "Glyco_trans_6"}]}, {"database": "InterPro", "id": "IPR029044", "properties": [{"key": "EntryName", "value": "Nucleotide-diphossugar_trans"}]}, {"database": "PANTHER", "id": "PTHR10462", "properties": [{"key": "EntryName", "value": "GLYCOSYLTRANSFERASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10462:SF29", "properties": [{"key": "EntryName", "value": "HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03414", "properties": [{"key": "EntryName", "value": "Glyco_transf_6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53448", "properties": [{"key": "EntryName", "value": "Nucleotide-diphospho-sugar transferases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "GDFYYLGGFFGGSVQEVQRLTRACHQAMMVDEANGIEAVWHDESHLNKYLLRHKPTKVLS", "length": 60, "molWeight": 6852, "crc64": "48BF1397D12B78B4", "md5": "90A59889AFB6A6B9F4A37C184D0FC727"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Active site": 1, "Binding site": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D36544"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLF6", "uniProtkbId": "A0AAU0QLF6_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56443.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56443.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 46, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 78, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 145, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 201, "modifier": "EXACT"}, "end": {"value": 223, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56443.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56443.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56443.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970336", "properties": [{"key": "ProteinId", "value": "WPO56443.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF42", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 83A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIGLYISVRYIYVSVRSESLRTTVDLLRFNHDNDFCFIYLRLCWNFVYWSIFVHIALIVILDFMTIRKVILKGDVDEAPMVFEILPCIGYLSLSLFKTYKMVTRRCVFENLIHELRSMWPDGEVAEDESSIVNKALKEVNIFIKVYYFCNNLLALSVMIPPYFSVLKRIIGYDVPRILPYSYWIPYDGTQPVWYEFTITLMAWQTFATLWCMLAGDLLFCVLLSHITTQFDLLCLRIRRLFYVTVDEQLIEDYPLGMIM", "length": 259, "molWeight": 30680, "crc64": "734FE9B09E216BA6", "md5": "A161D1D35374EA4F8E0E21586EDC061E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 4}, "uniParcId": "UPI00308B2C18"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DRD4", "uniProtkbId": "TX5A_POGMA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Pogonomyrmex maricopa", "commonName": "Maricopa harvester ant", "taxonId": 144040, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Hymenoptera", "Apocrita", "Aculeata", "Formicoidea", "Formicidae", "Myrmicinae", "Pogonomyrmex"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38110035"}], "value": "Myrmicitoxin(1)-Pm5a"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "38110035"}], "value": "MYRTX(1)-Pm5a"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}], "value": "Toxin that causes a rapid and irreversible paralysis when intrathoracically injected into insects (blowflies). Does not cause spontaneous nocifensive behaviors by intraplantar injection in mice"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "38110035"}], "value": "Expressed by the venom gland"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}], "value": "PD(50) [1 hour] is 43.7 nmol/g when intrathoracically injected into insects (blowfly L.caesar)"}], "commentType": "TOXIC DOSE"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}], "value": "Negative results: does not exhibit hemolytic and cytotoxic activities on HEK293 cells"}], "commentType": "MISCELLANEOUS"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the formicidae venom clade 2 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Propeptide", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "38110035"}], "featureId": "PRO_0000461255"}, {"type": "Peptide", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "Myrmicitoxin(1)-Pm5a", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}], "featureId": "PRO_0000461256"}, {"type": "Modified residue", "location": {"start": {"value": 60, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "Glutamine amide", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "38110035"}]}], "keywords": [{"id": "KW-0027", "category": "PTM", "name": "Amidation"}, {"id": "KW-0528", "category": "Molecular function", "name": "Neurotoxin"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "38110035", "citationType": "journal article", "authors": ["Robinson S.D.", "Deuis J.R.", "Niu P.", "Touchard A.", "Mueller A.", "Schendel V.", "Brinkwirth N.", "King G.F.", "Vetter I.", "Schmidt J.O."], "citationCrossReferences": [{"database": "PubMed", "id": "38110035"}, {"database": "DOI", "id": "10.1016/j.jbc.2023.105577"}], "title": "Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants.", "publicationDate": "2024", "journal": "J. Biol. Chem.", "firstPage": "105577", "lastPage": "105577", "volume": "300"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "IDENTIFICATION BY MASS SPECTROMETRY", "SUBCELLULAR LOCATION", "SYNTHESIS OF 34-60", "BIOASSAY", "TOXIC DOSE", "AMIDATION AT GLN-60"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}, {"value": "Venom gland", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR128464", "properties": [{"key": "ProteinId", "value": "WMI02502.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MKAIIFLFAVLTVVAIIIPIISGEPNAGPLAASIDLKQIMEKVKPDLLKMLDDIKAKIQQG", "length": 61, "molWeight": 6586, "crc64": "837E0FE05CF09981", "md5": "12CFC15795D797563E5FA23CF262A413"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "TOXIC DOSE": 1, "MISCELLANEOUS": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Propeptide": 1, "Peptide": 1, "Modified residue": 1}, "uniParcId": "UPI003091B4A9"}, "cluster_size": 4, "family": "Formicidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MLS3", "uniProtkbId": "A0AA96MLS3_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50052.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50052.1"}], "value": "von Willebrand factor A domain-containing protein-like protein"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 35, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 1231, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041687386"}, {"type": "Domain", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 228, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 265, "modifier": "EXACT"}, "end": {"value": 301, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 302, "modifier": "EXACT"}, "end": {"value": 338, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 431, "modifier": "EXACT"}, "end": {"value": 463, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 479, "modifier": "EXACT"}, "end": {"value": 511, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 544, "modifier": "EXACT"}, "end": {"value": 721, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 765, "modifier": "EXACT"}, "end": {"value": 947, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Region", "location": {"start": {"value": 510, "modifier": "EXACT"}, "end": {"value": 536, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1040, "modifier": "EXACT"}, "end": {"value": 1059, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1080, "modifier": "EXACT"}, "end": {"value": 1147, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 1162, "modifier": "EXACT"}, "end": {"value": 1192, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 513, "modifier": "EXACT"}, "end": {"value": 532, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1040, "modifier": "EXACT"}, "end": {"value": 1050, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1080, "modifier": "EXACT"}, "end": {"value": 1105, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1119, "modifier": "EXACT"}, "end": {"value": 1129, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 269, "modifier": "EXACT"}, "end": {"value": 279, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 291, "modifier": "EXACT"}, "end": {"value": 300, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 305, "modifier": "EXACT"}, "end": {"value": 315, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 309, "modifier": "EXACT"}, "end": {"value": 326, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 328, "modifier": "EXACT"}, "end": {"value": 337, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 453, "modifier": "EXACT"}, "end": {"value": 462, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 501, "modifier": "EXACT"}, "end": {"value": 510, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-0245", "category": "Domain", "name": "EGF-like domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50052.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460129", "properties": [{"key": "ProteinId", "value": "WNS50052.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd00054", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00198", "properties": [{"key": "EntryName", "value": "vWFA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "2.10.25.10", "properties": [{"key": "EntryName", "value": "Laminin"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR000742", "properties": [{"key": "EntryName", "value": "EGF-like_dom"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF84", "properties": [{"key": "EntryName", "value": "VWFA DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF25024", "properties": [{"key": "EntryName", "value": "EGF_TEN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PRINTS", "id": "PR00011", "properties": [{"key": "EntryName", "value": "EGFLAMININ"}]}, {"database": "PRINTS", "id": "PR00453", "properties": [{"key": "EntryName", "value": "VWFADOMAIN"}]}, {"database": "SMART", "id": "SM00181", "properties": [{"key": "EntryName", "value": "EGF"}, {"key": "MatchStatus", "value": "9"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS00022", "properties": [{"key": "EntryName", "value": "EGF_1"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "PROSITE", "id": "PS01186", "properties": [{"key": "EntryName", "value": "EGF_2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50026", "properties": [{"key": "EntryName", "value": "EGF_3"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "3"}]}], "sequence": {"value": "MPKDLKFSARTDIGTFATMISLVLCLTVLVGMSQAAEDDPTNSCPPTPLDIGLIIDTSKSIKDGQLVKLREALVAFVSALDVGPQERQVRVSAAGFGKAAELYFDFDDYTNKEEVLEQLRTLPRVEFFVGTETGKGIRLMQSTFADSNSGERPAAPDVTVVFTDGKSTNPKDLTLAMKEFESSDIKQFAIGIGSGIDIAELTEIAEGIEGQAYETTGFDQLVALANTIGSEVTCVCTPICKRGQCIHETGICDCQDPRWGGDDCSKPVCTPGCQNGGQCVVDGDGNHICECPAEWTGTDCSEPVCDTECKNGGQCAAGTGGEGHSCACPAEWTGSDCSEPVCDPACQNGGECTVDGCECTLEFTGADCSEPVCDPACQNGGECTVDGCECTLEFTGADCSEPVCDPACQNGGECTVDGCECTLEFTGADCSEPECKPACVNGVCDSDAGECVCNKGYTGEDCSTPPPPPPPPPPPPPTPAPECKPACVNGVCDSDAGECVCNKGYTGEDCNTQPPPPPPPPPPPPPPPPTEPPVAESCPQQAVDVVFILDSSNSIKNADLALLRTAVQDIARNLNVGPSDTQVRVAAIGYGGKSQLYFNFKRYYDKSILVKAIGRLKRVKVSRGTRLDLAFENMVKLFKAKKHGSRKNSRKIAIVVTDGKSTKPTKLQEIIPKLPKDVERYAVGVGRGIDQSELELIAQDEPSKVFYVDDFGKLNDLVERVTSAVECLCQPECVRGTCDVENRVCVCPDGWGGADCNIRCTQYYDLILVVDCSFSLNAEEFKEIKQYTKEVVSHLDIGRDQTHVGVVKFGYDVEFDFYLKSSYDKEFIMNRVSNMVRPPKYDSTNTSHALEYARQLFNAQGRDQSAFEHKIVLITDGRSTDTRYLWNTVNKLRDAGIQRYCVGVGEQMFSGKMWERAQNELKGIAGADDQVVFSPSFDELGDFVRTLADKLDEFAMEECTEEVEIIEAPDVKLIVIRKFGIAHDISLLKELLACEAGNPFSFPVSHAAWKAIGGALAELYPERMKGLTARAVKDRADKLVKDGRATDNTKARQSGTDEQYGRKEAALLEVVSLYEEAARKKKEEQGEAKQQKKTREENERVKAAEMRTAAFSTLGGKRAAATTSADSTSPGPVHHEGGKLKSKRTKAQAQSATSIGMLLEYLENKRAEDSELKKQQLELERQKFKASQAERSSMLQLISKMMDKCNKSVMYHSGNISKCIIIISIEYQSTA", "length": 1231, "molWeight": 133524, "crc64": "FABC750C962FF610", "md5": "7D0DE544B3661F35C8329D45E434342F"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 7, "Region": 3, "Coiled coil": 1, "Compositional bias": 4, "Disulfide bond": 7}, "uniParcId": "UPI002B30C281"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZER7", "uniProtkbId": "A0AB38ZER7_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02755.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02755.1"}], "value": "Venom S1 protease 31"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 148, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044319886"}, {"type": "Domain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 118, "modifier": "EXACT"}}, "description": "CUB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS01180"}]}, {"type": "Region", "location": {"start": {"value": 31, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 80, "modifier": "EXACT"}, "end": {"value": 97, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 148, "modifier": "EXACT"}, "end": {"value": 148, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02755.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02755.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02755.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02755.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517505", "properties": [{"key": "ProteinId", "value": "WXI02755.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008233", "properties": [{"key": "GoTerm", "value": "F:peptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00041", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.290", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000859", "properties": [{"key": "EntryName", "value": "CUB_dom"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "Pfam", "id": "PF00431", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01180", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGLVGVTILVILSLVGSGRADDVVLNLNDEGSETDIRSPSYPNPIPANSRSSWQINSPQGTKIKLYCTEANLPQDNPPGCDQFMLLIDAGETRRVVCGQQNGLSVEAEDNYMFIQLLTGAFEGGRVSCRASVTGHHSDNHRPDHLKSE", "length": 148, "molWeight": 16023, "crc64": "52EAA184E160F94C", "md5": "8CBEA3AEB32DE5052CC66B82CA8B015A"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Disulfide bond": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388BCB8D"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXW7", "uniProtkbId": "TXU29_MEGOP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Megalopyge opercularis", "commonName": "Southern flannel moth", "synonyms": ["Phalaena opercularis"], "taxonId": 1113279, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Megalopygidae", "Megalopyge"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-megalopygitoxin(2)-Mo9"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-MPTX(2)-Mo9"}, {"evidences": [{"evidenceCode": "ECO:0000312", "source": "EMBL", "id": "WJJ70365.1"}], "value": "U-MPTX.2-9"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Probable toxin"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Expressed by the venom apparatus"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Larvae"}], "commentType": "DEVELOPMENTAL STAGE"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "value": "Contains 2 disulfide bonds"}], "commentType": "PTM"}, {"commentType": "MASS SPECTROMETRY", "method": "MALDI", "molWeight": 3328.55, "molWeightError": 0.0, "note": "Monoisotopic mass.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the caterpillar 2 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Peptide", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "U-megalopygitoxin(2)-Mo9", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "featureId": "PRO_0000461525"}, {"type": "Modified residue", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 26, "modifier": "EXACT"}}, "description": "Pyrrolidone carboxylic acid", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}, {"type": "Modified residue", "location": {"start": {"value": 55, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "Threonine amide", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}], "keywords": [{"id": "KW-0027", "category": "PTM", "name": "Amidation"}, {"id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"id": "KW-0873", "category": "PTM", "name": "Pyrrolidone carboxylic acid"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "37428925", "citationType": "journal article", "authors": ["Walker A.A.", "Robinson S.D.", "Merritt D.J.", "Cardoso F.C.", "Goudarzi M.H.", "Mercedes R.S.", "Eagles D.A.", "Cooper P.", "Zdenek C.N.", "Fry B.G.", "Hall D.W.", "Vetter I.", "King G.F."], "citationCrossReferences": [{"database": "PubMed", "id": "37428925"}, {"database": "DOI", "id": "10.1073/pnas.2305871120"}], "title": "Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).", "publicationDate": "2023", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "e2305871120", "lastPage": "e2305871120", "volume": "120"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "MASS SPECTROMETRY", "SYNTHESIS OF 26-55", "PYROGLUTAMATE FORMATION AT GLN-26", "AMIDATION AT THR-55", "SUBCELLULAR LOCATION", "TISSUE SPECIFICITY", "DEVELOPMENTAL STAGE"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP514847", "properties": [{"key": "ProteinId", "value": "WJJ70365.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MKFIVLLLIVTSVLMMFAVTTEASPQVNHKIERAKCGQKGKCYDGVNVQCIDCNTG", "length": 56, "molWeight": 6147, "crc64": "79648B15B922AFB1", "md5": "631EF3AA588C12A8E2E303D7BEFB02BF"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "DEVELOPMENTAL STAGE": 1, "PTM": 1, "MASS SPECTROMETRY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Peptide": 1, "Modified residue": 2}, "uniParcId": "UPI00388C33BA"}, "cluster_size": 1, "family": "Megalopygidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8KYU2", "uniProtkbId": "A0AAU8KYU2_HALDU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28588.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28588.1"}], "value": "Lamin B"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 381, "modifier": "EXACT"}}, "description": "IF rod", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51842"}]}, {"type": "Domain", "location": {"start": {"value": 418, "modifier": "EXACT"}, "end": {"value": 539, "modifier": "EXACT"}}, "description": "LTD", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51841"}]}, {"type": "Region", "location": {"start": {"value": 381, "modifier": "EXACT"}, "end": {"value": 414, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 542, "modifier": "EXACT"}, "end": {"value": 625, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 97, "modifier": "EXACT"}, "end": {"value": 180, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 300, "modifier": "EXACT"}, "end": {"value": 345, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 570, "modifier": "EXACT"}, "end": {"value": 580, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 584, "modifier": "EXACT"}, "end": {"value": 597, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022754"}], "id": "KW-0403", "category": "Cellular component", "name": "Intermediate filament"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EGAS7BV8JDS8L", "citationType": "submission", "authors": ["Mikhailov K.", "Kravchuk O.", "Lyupina Y.", "Adameyko K."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28588.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP971922", "properties": [{"key": "ProteinId", "value": "XCN28588.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005882", "properties": [{"key": "GoTerm", "value": "C:intermediate filament"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "Gene3D", "id": "1.20.5.170", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.1260", "properties": [{"key": "EntryName", "value": "Lamin Tail domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.5.1160", "properties": [{"key": "EntryName", "value": "Vasodilator-stimulated phosphoprotein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR039008", "properties": [{"key": "EntryName", "value": "IF_rod_dom"}]}, {"database": "InterPro", "id": "IPR001322", "properties": [{"key": "EntryName", "value": "Lamin_tail_dom"}]}, {"database": "InterPro", "id": "IPR036415", "properties": [{"key": "EntryName", "value": "Lamin_tail_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR45721", "properties": [{"key": "EntryName", "value": "LAMIN DM0-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45721:SF11", "properties": [{"key": "EntryName", "value": "LAMIN DM0-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00038", "properties": [{"key": "EntryName", "value": "Filament"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00932", "properties": [{"key": "EntryName", "value": "LTD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01391", "properties": [{"key": "EntryName", "value": "Filament"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF64593", "properties": [{"key": "EntryName", "value": "Intermediate filament protein, coiled coil region"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF74853", "properties": [{"key": "EntryName", "value": "Lamin A/C globular tail domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51842", "properties": [{"key": "EntryName", "value": "IF_ROD_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51841", "properties": [{"key": "EntryName", "value": "LTD"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEQSAEGNPERLSLSPLTRIQEKEHFQSLNERLEDYIDKVKSLKGRNAGLEAEIAALRDDIKRATQNVKDLYEPKLAAIRALIDKTAREKARQQLLGQGLDSDNRRLEDDIAALEKKEEDLQNRLDSTTQKTTTTEGKYRNAVKDKLDLTGRLKEGEKELDDLRKQYDRLLKRVEDATVDRVDHNNKIMSLTEELTFNKKKNALELDTLRDADSRVAMEKSQITTDMTDQVDGQQDDRIQELKDRSKLECDQLKQELEMVYGDQIEKLQTQNARDAENIGSLSLSVRDLNEKDALSDRELAKLKDQAEQLKHQLRHQAEDLDKIKEDRKDEVRRLVDQQQDLRDRQDGKMKEFKHLFDLKIKLDKETERYRKLLEGEENRLNIVPSPGTKRRKPPPVDTQDSPCSPPKRPKHHIEKQTVNQANVSSTALDYIQITDVDLSGAYIKLKNTSDQAETLSSFKLVHTVLDSGTEDVFVFHQRSRLKGGVMVSVWGYKAGVDHNPPSDVICKHIPFWGVGKDTETQLFNNKGEVMATYVQHKQHTSSIHYTSDDPTGDGMETDGPATSEDEGVATTTTEPQLTKDTGEDSDDEEKEEEELPQGELFHEEDQAPEQGDENRGQNRSCTIA", "length": 625, "molWeight": 71367, "crc64": "206744923C5038CB", "md5": "632A4C8F314385F3E347F626D792393E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 2, "Region": 2, "Coiled coil": 3, "Compositional bias": 2}, "uniParcId": "UPI0035D3516B"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAB0B259", "uniProtkbId": "A0AAB0B259_CHLTH", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Chlamydia trachomatis", "taxonId": 813, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8DJ2"}], "lineage": ["Bacteria", "Pseudomonadati", "Chlamydiota", "Chlamydiia", "Chlamydiales", "Chlamydiaceae", "Chlamydia/Chlamydophila group", "Chlamydia"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8DJ2"}], "value": "Adhesin"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "T-Q ester bond containing", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF18202"}]}, {"type": "Region", "location": {"start": {"value": 122, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 144, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 124, "modifier": "EXACT"}, "end": {"value": 124, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8DJ2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108"}}, {"type": "Binding site", "location": {"start": {"value": 126, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8DJ2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108"}}, {"type": "Binding site", "location": {"start": {"value": 128, "modifier": "EXACT"}, "end": {"value": 128, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8DJ2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108"}}, {"type": "Binding site", "location": {"start": {"value": 130, "modifier": "EXACT"}, "end": {"value": 130, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8DJ2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108"}}, {"type": "Binding site", "location": {"start": {"value": 132, "modifier": "EXACT"}, "end": {"value": 132, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29108"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8DJ2"}], "ligand": {"name": "Ca(2+)", "id": "ChEBI:CHEBI:29108"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8DJ2"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8DJ2"}], "id": "KW-0106", "category": "Ligand", "name": "Calcium"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8DJ2"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-CRFHS27VLU3L9", "citationType": "submission", "authors": ["Choksi Z.N.", "Young P.G.", "Squire C.J."], "title": "Intramolecular ester bond-containing repeat domain from Chlamydia trachomatis adhesin.", "publicationDate": "JUN-2022", "submissionDatabase": "PDB data bank"}, "referencePositions": ["X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH CA(2+)"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8DJ2"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8DJ2", "properties": [{"key": "Method", "value": "X-ray"}, {"key": "Resolution", "value": "1.50 A"}, {"key": "Chains", "value": "A/B=1-153"}]}, {"database": "SMR", "id": "A0AAB0B259", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.60.40.3930", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR041100", "properties": [{"key": "EntryName", "value": "TQ"}]}, {"database": "NCBIfam", "id": "NF033903", "properties": [{"key": "EntryName", "value": "VaFE_rpt"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF18202", "properties": [{"key": "EntryName", "value": "TQ"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "GAKKKHVSPKGKLATTVSVGGVKASVGGGVRVTSAQAGAGVDVADTIAYTGLVAGEAYSVSGSLFEVADGRTVGDAIVTKTEQFTASDSGAGEWTVEFGRVAGLEPGKQYVVFETATSVKDLVDTDGDDVPDAAQVEKHEDPNDASQTVVVEE", "length": 153, "molWeight": 15502, "crc64": "B931AD681F7A216B", "md5": "319AD462F25F43BD99CA15778CC2B2F5"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1, "Binding site": 5}, "uniParcId": "UPI0026F37D3C"}, "cluster_size": 1, "family": "Chlamydiaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0P7N0", "uniProtkbId": "A0AAF0P7N0_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2024-10-02", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paratelphusula gibbosa", "taxonId": 511413, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Paratelphusula"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}], "value": "G-protein coupled receptor"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}], "value": "scaffold1802736"}}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 64, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 105, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}], "value": "S85", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}], "value": "S85", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS69299.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR517352", "properties": [{"key": "ProteinId", "value": "WMS69299.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "RVPREAEDCQASSFIPPDNQTWWVACLIHDTSNKGYFIAYVWIRQTLVTFLPIIAVVCLNLLTLRGFMRHRKIRRDILNRQVRGQPSVMSNNREEKNLMGLLIAV", "length": 105, "molWeight": 12224, "crc64": "BA742573328CD4CC", "md5": "C5B19EC7DCE3DF0DCBED7D46EA2CDD05"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B281071"}, "cluster_size": 1, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB32TRL2", "uniProtkbId": "A0AB32TRL2_DANRE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Danio rerio", "commonName": "Zebrafish", "synonyms": ["Brachydanio rerio"], "taxonId": 7955, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}, {"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Cypriniformes", "Danionidae", "Danioninae", "Danio"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}], "value": "Cilia- and flagella-associated protein 184 isoform X1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}, {"evidenceCode": "ECO:0000313", "source": "ZFIN", "id": "ZDB-GENE-081022-156"}], "value": "cfap184"}, "synonyms": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}], "value": "ccdc96"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}], "value": "zgc:194827"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}], "value": "zgc:194851"}]}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004138"}], "value": "Cell projection, cilium", "id": "SL-0066"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 292, "modifier": "EXACT"}, "end": {"value": 367, "modifier": "EXACT"}}, "description": "CCDC113/CCDC96 coiled-coil", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF13870"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 158, "modifier": "EXACT"}, "end": {"value": 192, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 304, "modifier": "EXACT"}, "end": {"value": 364, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 46, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 89, "modifier": "EXACT"}, "end": {"value": 125, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023273"}], "id": "KW-0966", "category": "Cellular component", "name": "Cell projection"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}], "id": "KW-0969", "category": "Cellular component", "name": "Cilium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}], "id": "KW-0282", "category": "Cellular component", "name": "Flagellum"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AB32TRL2"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "23594743", "citationType": "journal article", "authoringGroup": ["Genome Reference Consortium Zebrafish"], "authors": ["Howe K.", "Clark M.D.", "Torroja C.F.", "Torrance J.", "Berthelot C.", "Muffato M.", "Collins J.E.", "Humphray S.", "McLaren K.", "Matthews L.", "McLaren S.", "Sealy I.", "Caccamo M.", "Churcher C.", "Scott C.", "Barrett J.C.", "Koch R.", "Rauch G.J.", "White S.", "Chow W.", "Kilian B.", "Quintais L.T.", "Guerra-Assuncao J.A.", "Zhou Y.", "Gu Y.", "Yen J.", "Vogel J.H.", "Eyre T.", "Redmond S.", "Banerjee R.", "Chi J.", "Fu B.", "Langley E.", "Maguire S.F.", "Laird G.K.", "Lloyd D.", "Kenyon E.", "Donaldson S.", "Sehra H.", "Almeida-King J.", "Loveland J.", "Trevanion S.", "Jones M.", "Quail M.", "Willey D.", "Hunt A.", "Burton J.", "Sims S.", "McLay K.", "Plumb B.", "Davis J.", "Clee C.", "Oliver K.", "Clark R.", "Riddle C.", "Elliot D.", "Eliott D.", "Threadgold G.", "Harden G.", "Ware D.", "Begum S.", "Mortimore B.", "Mortimer B.", "Kerry G.", "Heath P.", "Phillimore B.", "Tracey A.", "Corby N.", "Dunn M.", "Johnson C.", "Wood J.", "Clark S.", "Pelan S.", "Griffiths G.", "Smith M.", "Glithero R.", "Howden P.", "Barker N.", "Lloyd C.", "Stevens C.", "Harley J.", "Holt K.", "Panagiotidis G.", "Lovell J.", "Beasley H.", "Henderson C.", "Gordon D.", "Auger K.", "Wright D.", "Collins J.", "Raisen C.", "Dyer L.", "Leung K.", "Robertson L.", "Ambridge K.", "Leongamornlert D.", "McGuire S.", "Gilderthorp R.", "Griffiths C.", "Manthravadi D.", "Nichol S.", "Barker G.", "Whitehead S.", "Kay M.", "Brown J.", "Murnane C.", "Gray E.", "Humphries M.", "Sycamore N.", "Barker D.", "Saunders D.", "Wallis J.", "Babbage A.", "Hammond S.", "Mashreghi-Mohammadi M.", "Barr L.", "Martin S.", "Wray P.", "Ellington A.", "Matthews N.", "Ellwood M.", "Woodmansey R.", "Clark G.", "Cooper J.", "Cooper J.", "Tromans A.", "Grafham D.", "Skuce C.", "Pandian R.", "Andrews R.", "Harrison E.", "Kimberley A.", "Garnett J.", "Fosker N.", "Hall R.", "Garner P.", "Kelly D.", "Bird C.", "Palmer S.", "Gehring I.", "Berger A.", "Dooley C.M.", "Ersan-Urun Z.", "Eser C.", "Geiger H.", "Geisler M.", "Karotki L.", "Kirn A.", "Konantz J.", "Konantz M.", "Oberlander M.", "Rudolph-Geiger S.", "Teucke M.", "Lanz C.", "Raddatz G.", "Osoegawa K.", "Zhu B.", "Rapp A.", "Widaa S.", "Langford C.", "Yang F.", "Schuster S.C.", "Carter N.P.", "Harrow J.", "Ning Z.", "Herrero J.", "Searle S.M.", "Enright A.", "Geisler R.", "Plasterk R.H.", "Lee C.", "Westerfield M.", "de Jong P.J.", "Zon L.I.", "Postlethwait J.H.", "Nusslein-Volhard C.", "Hubbard T.J.", "Roest Crollius H.", "Rogers J.", "Stemple D.L."], "citationCrossReferences": [{"database": "PubMed", "id": "23594743"}, {"database": "DOI", "id": "10.1038/nature12111"}], "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "publicationDate": "2013", "journal": "Nature", "firstPage": "498", "lastPage": "503", "volume": "496"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000437"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FT6AD0HQEQTFJ", "citationType": "submission", "authoringGroup": ["RefSeq"], "publicationDate": "APR-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}], "value": "Tuebingen", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "RefSeq", "id": "XP_068078420.1"}]}], "uniProtKBCrossReferences": [{"database": "RefSeq", "id": "XP_068078420.1", "properties": [{"key": "NucleotideSequenceId", "value": "XM_068222319.1"}]}, {"database": "GeneID", "id": "559167", "properties": [{"key": "Description", "value": "-"}]}, {"database": "CTD", "id": "257236", "properties": [{"key": "Description", "value": "-"}]}, {"database": "ZFIN", "id": "ZDB-GENE-081022-156", "properties": [{"key": "GeneName", "value": "cfap184"}]}, {"database": "Proteomes", "id": "UP000000437", "properties": [{"key": "Component", "value": "Chromosome 7"}]}, {"database": "GO", "id": "GO:0031514", "properties": [{"key": "GoTerm", "value": "C:motile cilium"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR051885", "properties": [{"key": "EntryName", "value": "CC_CF"}]}, {"database": "InterPro", "id": "IPR025254", "properties": [{"key": "EntryName", "value": "CCDC113/CCDC96_CC"}]}, {"database": "PANTHER", "id": "PTHR15654", "properties": [{"key": "EntryName", "value": "COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR15654:SF1", "properties": [{"key": "EntryName", "value": "COILED-COIL DOMAIN-CONTAINING PROTEIN 96"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13870", "properties": [{"key": "EntryName", "value": "CCDC113_CCDC96_CC"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEEESLEYTHEESFVLETDTLMENTKTLEGPADAEQVMEEETEEPEAPNNPEAVEEDKAEQLLTEDTSVPETSEQQTGEIQIEQHLITEEDPLMNETLEDTEGPETEPSLEDSEDEEEEEEDEENSLPAPEPENERSISPPEEPQAHTEDEEVDPSIIKEKMELLHKLQSENEKLNKINQQLQTRIAEHFSKKKGDQHVKLDEDISEQEQYEKYMQLIADMKEQQLHFSKLHQERMEDLHLQSSEKLKQVEQELRFFAALKYETVMKASLTGKVGKQETLAKVELLKAEELKQEDKLVCVRLNNIKLKNKISKYERALRSKRELVDGLLLMDFEQLKTENQSFMDKLEERSEELHRLKKKVASSVQVGSGPETMICVRRTVSPPTWRTTAPGLSAAPRMVEICVEIFLTRAPGKQKVRTLLPFEEAARM", "length": 429, "molWeight": 49528, "crc64": "BB8E2CC621439078", "md5": "32908B0CF152D86C66FAC6D355F7B823"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Coiled coil": 2, "Compositional bias": 3}, "uniParcId": "UPI00359FEEC6"}, "cluster_size": 1, "family": "Danionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLG3", "uniProtkbId": "A0AAU0QLG3_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56458.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 49, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 90, "modifier": "EXACT"}, "end": {"value": 107, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 149, "modifier": "EXACT"}, "end": {"value": 171, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 202, "modifier": "EXACT"}, "end": {"value": 219, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 283, "modifier": "EXACT"}, "end": {"value": 303, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 315, "modifier": "EXACT"}, "end": {"value": 336, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56458.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56458.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970351", "properties": [{"key": "ProteinId", "value": "WPO56458.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MENFGRYLPEDFDEHEEEIVLKTFEETYKQVMFAMSVGMIYPNPATEKWRLLAIPFYIGLVSPVLYVMAYNMKIAADINDVDAIFKQSTIMGPFCGQFFKMLFLFLHRRNARAIFDEINHDYSVINTLRMRYKQVARHWISSNLAYEWRWAYCVTFATFSFPVLGVFRNMYSAFFDEEPRRLYIHDVDLPFGYQEKKFDTPVYEFIFLQTCICSCMYYINFVGYDGFLVLSVQHVSLKMKLCTVALEDAMKIEDEALRQVQIETVIKEHIKIYNYVGTVTETFSVWLSTITTAIVLHLCSCVYHLQGHGLQDVQFVFTTVAAVIYIYMLCSVVGTMSMNSLTMSDDIYCCGWENISDTKSRRMLVFMLARSQEPIQIKSLSMFNLDMEMFVMLVKMAYSMFTFLQQT", "length": 407, "molWeight": 47704, "crc64": "78273A10C6DAB6DC", "md5": "84989C53D53E2AC906E7083002E633F2"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 6}, "uniParcId": "UPI00308E0156"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0UI06", "uniProtkbId": "A0AAU0UI06_ARGRE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Argyrosomus regius", "commonName": "Meagre", "taxonId": 172269, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WQQ41823.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Neoteleostei", "Acanthomorphata", "Eupercaria", "Sciaenidae", "Argyrosomus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WQQ41823.1"}], "value": "Interleukin 8"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WQQ41823.1"}], "value": "il-8"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043502163"}, {"type": "Non-terminal residue", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WQQ41823.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-P8SQULEHNIGI", "citationType": "submission", "authors": ["Rocha A.", "Costas B."], "title": "Genetic markers of meagre immune system activation.", "publicationDate": "DEC-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WQQ41823.1"}], "value": "Meagre-il8", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WQQ41823.1"}], "value": "Head kidney", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WQQ41823.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP033609", "properties": [{"key": "ProteinId", "value": "WQQ41823.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSIITIVALLVFLAIPEGSSLGDQAVLLRCQCITKEKKPIGRYIGQVEVIPA", "length": 52, "molWeight": 5597, "crc64": "C6768DDEFE32D6F8", "md5": "1660F918503D658FAAEF9D1D826BC11D"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D3A7A3"}, "cluster_size": 1, "family": "Sciaenidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HC10", "uniProtkbId": "A0AA96HC10_9MOLL", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Meiomenia swedmarki", "taxonId": 1500384, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25260.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Aplacophora", "Solenogastres", "Pholidoskepia", "Meiomeniidae", "Meiomenia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25260.1"}], "value": "Hypoxia-inducible factor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 83, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 226, "modifier": "EXACT"}, "end": {"value": 277, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 345, "modifier": "EXACT"}, "end": {"value": 371, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 447, "modifier": "EXACT"}, "end": {"value": 568, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 603, "modifier": "EXACT"}, "end": {"value": 622, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 345, "modifier": "EXACT"}, "end": {"value": 354, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 474, "modifier": "EXACT"}, "end": {"value": 483, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 500, "modifier": "EXACT"}, "end": {"value": 529, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 531, "modifier": "EXACT"}, "end": {"value": 552, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25260.1"}], "value": "Meio1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25260.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354995", "properties": [{"key": "ProteinId", "value": "WNN25260.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14598", "properties": [{"key": "EntryName", "value": "PAS_11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MEDGKRKIKRRYSEKRRQAAKEAAQIRRRIEAEIYQSMVSHLPLDLNISGSHNYSQALKISVAFLQLHQFSSQSNRCSVVKVEDSHAPKILEALHGFFVILSANGNVIFVSENIIQHLGLSQAVVLGCSIYEFLHHCDIKQVRSILTQRCNTRSDRVHFLCRIKCTLTDKGALVNIKSAPHRVFEFIGRRVSSDSGVYLMALCQPILHPASIEIALDSHTFLSRHDPDMVFTHCDDQMKKLVGFTRKDVIGRSAYEYHHACDHDILVSAYTDLFSKGQSVSEAYRFLVKHGGYVPMISQSTILYHTVSRQPRSIVSVYFVLGGVQCRDVIFSHVQVPKARTLTNRLTHNNSAANETKEDQQSNAKSELPVLLTSPVNKNLPTIRNSKTEISTEKKLRLRAPSLPKGGDVQIWSKLPKYAIFGALKMPVGSTESVLMSTKSVLTPIPAAASRDSDSDVEATHTPLSAPCDDDLPPLESQSPPSLGGLDLSNDSPHSRLGKVSTTHGSTGRSNTHQLSPHVSSPNRSTSHFDLSPDHDLPPDREPRSHDTEQSCDKQYAPNEKPTHSRQTDASILKHLLLFGTKPTPPLSPGSDGTNSVRTHGQKVSPLGHVTTTHRQGPVHRNQKVYEELSSTDYDTYAPADQTSLLYGREIWEALES", "length": 657, "molWeight": 73007, "crc64": "B9C5E9D09324DFF5", "md5": "2E530F5920260EB3F8C2A33CC4D1C071"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 2, "Region": 3, "Compositional bias": 4}, "uniParcId": "UPI002B2FE321"}, "cluster_size": 1, "family": "Meiomeniidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38Z7F1", "uniProtkbId": "A0AB38Z7F1_PAESU", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia suffruticosa", "commonName": "Tree peony", "synonyms": ["Paeonia moutan"], "taxonId": 45171, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20325.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20325.1"}], "value": "B3 domain-containing protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 84, "modifier": "EXACT"}, "end": {"value": 132, "modifier": "EXACT"}}, "description": "TF-B3", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50863"}]}, {"type": "Domain", "location": {"start": {"value": 190, "modifier": "EXACT"}, "end": {"value": 288, "modifier": "EXACT"}}, "description": "TF-B3", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50863"}]}, {"type": "Domain", "location": {"start": {"value": 360, "modifier": "EXACT"}, "end": {"value": 458, "modifier": "EXACT"}}, "description": "TF-B3", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50863"}]}, {"type": "Domain", "location": {"start": {"value": 525, "modifier": "EXACT"}, "end": {"value": 626, "modifier": "EXACT"}}, "description": "TF-B3", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50863"}]}, {"type": "Region", "location": {"start": {"value": 307, "modifier": "EXACT"}, "end": {"value": 337, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-67NUCHPS7RPVN", "citationType": "submission", "authors": ["Zhang Y.", "Gai S."], "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20325.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR237910", "properties": [{"key": "ProteinId", "value": "WRI20325.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd10017", "properties": [{"key": "EntryName", "value": "B3_DNA"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Gene3D", "id": "2.40.330.10", "properties": [{"key": "EntryName", "value": "DNA-binding pseudobarrel domain"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "InterPro", "id": "IPR003340", "properties": [{"key": "EntryName", "value": "B3_DNA-bd"}]}, {"database": "InterPro", "id": "IPR015300", "properties": [{"key": "EntryName", "value": "DNA-bd_pseudobarrel_sf"}]}, {"database": "InterPro", "id": "IPR039218", "properties": [{"key": "EntryName", "value": "REM_fam"}]}, {"database": "PANTHER", "id": "PTHR31674", "properties": [{"key": "EntryName", "value": "B3 DOMAIN-CONTAINING PROTEIN REM-LIKE 3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31674:SF62", "properties": [{"key": "EntryName", "value": "B3 DOMAIN-CONTAINING PROTEIN REM14-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02362", "properties": [{"key": "EntryName", "value": "B3"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SMART", "id": "SM01019", "properties": [{"key": "EntryName", "value": "B3"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "SUPFAM", "id": "SSF101936", "properties": [{"key": "EntryName", "value": "DNA-binding pseudobarrel domain"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS50863", "properties": [{"key": "EntryName", "value": "B3"}, {"key": "MatchStatus", "value": "4"}]}], "sequence": {"value": "MTLYFNVKPFAQYLFIREYLPALLEAENTGPQSSHTSSLLDGMMADTRMRPTNPHFFKFLVLDFRSNFKSDTANLRSSRGGGEKIWPVKLNGRRLEDGWMDFIRDHDLHEGDFLLFRHLGNFVFDVTVFDPSTCVREYPPSDDIDVDSLDDENDSAQEKSVNHLYEAEDNTPMNKKIKKHSTTSLGIEHSCFVATVKPSDRELKLLIPQPFARLNGLTNGSYNKMILMDEKQELWPVRVRMKKSDKRVYIGKGWRNFCIANRIKSGDSFIFELIKKGKTPMLKFHRMQEVLERNSMDMQETTPKAIASSSALSSRKPRNMKNCKQSTPKEGPVKYLRENNTPMNKKIETHSTTSLPFENPYFVATAKRNEKDFRLYIPLPFARPNGLTNRSYNMMTLMDEKQNLWPVRVGQKKYKDRVYIGKGWRNFWIANGIREGDSFIFELIKKGNKPILKFHRFKGNSMAMQETAPKAIATSSACPSTRKPRNVKNCVVNTPKEESVKSFCANQSAQNKQTRMLATQLAFGNPFFECTVRPSNKSRLYVPSTFCQQTGLLKGSCSCSSKILVRDEKQKSWPMNLLRYESNRNIVYIGDGWRDFQVKNGLKVGDSFVLEFIENSKMPILRFHRKF", "length": 627, "molWeight": 72409, "crc64": "7ED204AEB0643066", "md5": "0294E1457CF943BBA7259E899CF1DA75"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 4, "Region": 1}, "uniParcId": "UPI00388BEE0F"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N5Y2", "uniProtkbId": "A0AAN0N5Y2_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34091.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34091.1"}], "value": "Dopamine-like receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 15, "modifier": "EXACT"}, "end": {"value": 36, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 57, "modifier": "EXACT"}, "end": {"value": 77, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 97, "modifier": "EXACT"}, "end": {"value": 120, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 676, "modifier": "EXACT"}, "end": {"value": 696, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 716, "modifier": "EXACT"}, "end": {"value": 737, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 734, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}, {"type": "Region", "location": {"start": {"value": 582, "modifier": "EXACT"}, "end": {"value": 613, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 323, "modifier": "EXACT"}, "end": {"value": 372, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 582, "modifier": "EXACT"}, "end": {"value": 603, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34091.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155017", "properties": [{"key": "ProteinId", "value": "WRW34091.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0045202", "properties": [{"key": "GoTerm", "value": "C:synapse"}, {"key": "GoEvidenceType", "value": "IEA:GOC"}]}, {"database": "GO", "id": "GO:0001591", "properties": [{"key": "GoTerm", "value": "F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24248", "properties": [{"key": "EntryName", "value": "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24248:SF125", "properties": [{"key": "EntryName", "value": "DOPAMINE D2-LIKE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVNIDWELSDVLCDFWMSVDVMCSTASILNLVAISIDRYIAVTQPIKYAKHKSNNRVACTIAIVWIVSLLIGCPIWLGLNTSEERTSNVCIFVNSDFIIYSSLGSFYIPCCLMVFLYYRIFKEIRKRSKRTRIKNFTGNTSSSGHVNKKTDAFYQSKNDSYVNVNVNKNQLIGQKKTKITSDKTSSQLEFISEINENQCKYKPKTNCIRKYIPLYKKEDKLNNFDEEDEEDEETDLTENEIKITNYSNKFNKNYFNKNDKKQTKICQKLKLKNENFSTSNLDELDENSTNSVVIKNLSALEKTNQKDVNKNSIKRRFINRFDLSLKNKNKEDLDKTISSLKDEISDELKDEIELKELNSDELKDANKEYSKNKIIKKFKIQVDDNDSENEIKNDVSYNDNFNNNLVENNIKNNHDLIDNEDNKYDCEIIHNPSAIFSKLTPENLIEKKSIGVCVDCGKYFDEKKSICIEQNENKQNIFTLEINAGSNKKEKSYNILDQKEDLIKNEIENFEILENQIAIEYDSQLYCECDHQTNINKEFNDNVLEKIDNVDSESKKSFTLHQNNKITEKIIKKLKRNPLISLPSNLKKTSSSSSSVKPSYSTNHTESSVSFKNSDEKINSKTYLNKQDILDKDSTNISIKQLSKKKSCFYLGRKQKNSRKKQEKASAKRERKATKTLAIVLGVFLFCWVPFFSINIMDAICIKLQANDCKLGISAFLFATWLGYINSCINPIIYTIFNTEFRKVFIKILGL", "length": 751, "molWeight": 86976, "crc64": "F1DF68076DD7A13B", "md5": "A9A9E5C655E8CA2C9EC9B60EAD622ED2"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 5, "Domain": 1, "Region": 1, "Coiled coil": 1, "Compositional bias": 1}, "uniParcId": "UPI003245AE11"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QMJ5", "uniProtkbId": "A0AAU0QMJ5_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56453.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56453.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 81, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043983966"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56453.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56453.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56453.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970346", "properties": [{"key": "ProteinId", "value": "WPO56453.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPLVVYCFGGELLISADLALATAAYSCGWEAMRPEEARSLLKLLSSAQRPLLYTAAGIFVMNRETFGDVVQVVYKIYAVFN", "length": 81, "molWeight": 8924, "crc64": "108B352B115B2A88", "md5": "C074D632C6A6B133FBF6DEF75F19542F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0030858A21"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0X8", "uniProtkbId": "A0AA96S0X8_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50072.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50072.1"}], "value": "Cubilin-like protein"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00059"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 380, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041642745"}, {"type": "Domain", "location": {"start": {"value": 136, "modifier": "EXACT"}, "end": {"value": 240, "modifier": "EXACT"}}, "description": "CUB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS01180"}]}, {"type": "Region", "location": {"start": {"value": 264, "modifier": "EXACT"}, "end": {"value": 331, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 308, "modifier": "EXACT"}, "end": {"value": 318, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50072.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460149", "properties": [{"key": "ProteinId", "value": "WNS50072.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.60.120.290", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000859", "properties": [{"key": "EntryName", "value": "CUB_dom"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "Pfam", "id": "PF00431", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01180", "properties": [{"key": "EntryName", "value": "CUB"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTQLFFVAIAICATAVSAVPSLGTPPPTPTEPSKVAGHSINLEREKHGYFTSEWTPNTMKCFGRVEAVVEVCPITRKEYFIRYVDEGPSAGEQSLGSVYLSKRRNSWCILEKQYVRDNRNATSMPLARENVIYIKSSANDSGKTYALSKEVVWQLEIPPNYGAYLIMNPFSLQAPSRTKHQCIDYVAVHFHENEYSVPKLLCGMRHEVLLVNVNASKLTIKFVSDESVNQGGFHGGLLIYPAADLIKLSGYGMNVMSMMARRARRHPNGGSGMGPISVTRPSLPVPSDDCNAGDSDCEKVQPQPQPAHDPKPEPKPEPEPEPEPEPKPIANELDPKAMWCFSDIVQNGFEAALKHLGDSSSLQCQMFAQIFLQDDYVAPT", "length": 380, "molWeight": 42031, "crc64": "A0AEF5827288CC22", "md5": "A2B77359F72FF2FD00F7F0913D522141"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B27D28C"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTW6", "uniProtkbId": "A0AAT9UTW6_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41711.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41711.1"}], "value": "Cytochrome P450 4461P2"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 491, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043658689"}, {"type": "Binding site", "location": {"start": {"value": 431, "modifier": "EXACT"}, "end": {"value": 431, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41711.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117271", "properties": [{"key": "ProteinId", "value": "WIM41711.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MITIVLFTCLIALSLRYLLQKQNTRFYQLLEHFPSYPTYPLIGNLYKLYGPQDDNIGKMEKIMEPYDRLLFWIGPIPTIMLKKYDDIMTVTNQCHDRDFHDFLKPWTDVGIVTARYDEWKKSRKMLSPAFSSQMLTKYVEVFNEKASILADQFRSVVDTDEMVDIWDIVVNANMNTALENIMGVSCEEKNNGGFTQVWMKALQNMSKRISTPWLHSRFALWIYLNITGKIKLVEYVNEFPTKIIKDTLHDIRNGNEPVHSSKTVIDLLVKKSLTDDITETRMKDEVLQLIATGMETSALNVSFSLLMLAIHQDVQQKVYQEIKRLTPNDAPLTFDQLTNDLKYLEQCIRETGRMYTASIVTLRYTHKECALHDNKIIPAGTNVLLHLHLSHYDKDLYENPRNWDPQHFSEQAVAKRPKGSDLLFGFGARSCIGYKYALLSIKTQLVHILRRYHLSTDIRELTADNLKSDLMVRSKIGYPIRFVSRQKFPGF", "length": 491, "molWeight": 57073, "crc64": "98B2599C1F9B450D", "md5": "4A235E53CD3A860D2FC99A22D3BF3331"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Binding site": 1}, "uniParcId": "UPI0035D30E99"}, "cluster_size": 3, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38YA08", "uniProtkbId": "A0AB38YA08_9ACAR", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39421.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39421.1"}], "value": "Elongation factor alpha"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 82, "modifier": "EXACT"}, "end": {"value": 107, "modifier": "EXACT"}}, "description": "Elongation factor 1 beta central acidic region eukaryote", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM01182"}]}, {"type": "Region", "location": {"start": {"value": 62, "modifier": "EXACT"}, "end": {"value": 91, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 75, "modifier": "EXACT"}, "end": {"value": 91, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39421.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 122, "modifier": "EXACT"}, "end": {"value": 122, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39421.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39421.1"}], "id": "KW-0251", "category": "Molecular function", "name": "Elongation factor"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39421.1"}], "id": "KW-0648", "category": "Biological process", "name": "Protein biosynthesis"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FCH8NLO8SBUEG", "citationType": "submission", "authors": ["Augustine N.", "Selvapandian U.", "Muthugoundar M."], "title": "Evaluation of reference genes for expression studies in the broad mite, Polyphagotarsonemus latus (Acari: Tarsonemidae).", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIW39421.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR134568", "properties": [{"key": "ProteinId", "value": "WIW39421.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005829", "properties": [{"key": "GoTerm", "value": "C:cytosol"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005853", "properties": [{"key": "GoTerm", "value": "C:eukaryotic translation elongation factor 1 complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005085", "properties": [{"key": "GoTerm", "value": "F:guanyl-nucleotide exchange factor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0003746", "properties": [{"key": "GoTerm", "value": "F:translation elongation factor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1050.130", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR018940", "properties": [{"key": "EntryName", "value": "EF-1_beta_acid_region_euk"}]}, {"database": "InterPro", "id": "IPR049720", "properties": [{"key": "EntryName", "value": "EF1B_bsu/dsu"}]}, {"database": "InterPro", "id": "IPR036282", "properties": [{"key": "EntryName", "value": "Glutathione-S-Trfase_C_sf"}]}, {"database": "InterPro", "id": "IPR001326", "properties": [{"key": "EntryName", "value": "Transl_elong_EF1B_B/D_CS"}]}, {"database": "PANTHER", "id": "PTHR11595", "properties": [{"key": "EntryName", "value": "EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11595:SF21", "properties": [{"key": "EntryName", "value": "ELONGATION FACTOR 1-BETA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10587", "properties": [{"key": "EntryName", "value": "EF-1_beta_acid"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01182", "properties": [{"key": "EntryName", "value": "EF-1_beta_acid"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47616", "properties": [{"key": "EntryName", "value": "GST C-terminal domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00824", "properties": [{"key": "EntryName", "value": "EF1BD_1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "ERSYIEGYQPSQADVLVLNALKSTPSKATPNVYRWYTHIQSFNADERKKFAQKSLNSEVAKFLDDKPGPSPAAAADDDDVDLFGSDEEDAEAEKIKEERLKAYAEKKSKKPALIAKSSIVLD", "length": 122, "molWeight": 13579, "crc64": "39D3B2EDC386894E", "md5": "4A13FBC236E030C4DB2D00D9D1570561"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 2}, "uniParcId": "UPI00388C25B2"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8L1N9", "uniProtkbId": "A0AAU8L1N9_HALDU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28598.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28598.1"}], "value": "SFRPb"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 752, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043650219"}, {"type": "Domain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "FZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50038"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 114, "modifier": "EXACT"}, "end": {"value": 138, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022837"}], "id": "KW-0106", "category": "Ligand", "name": "Calcium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EGAS7BV8JDS8L", "citationType": "submission", "authors": ["Mikhailov K.", "Kravchuk O.", "Lyupina Y.", "Adameyko K."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28598.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP971932", "properties": [{"key": "ProteinId", "value": "XCN28598.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042813", "properties": [{"key": "GoTerm", "value": "F:Wnt receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0017147", "properties": [{"key": "GoTerm", "value": "F:Wnt-protein binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0060070", "properties": [{"key": "GoTerm", "value": "P:canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0035567", "properties": [{"key": "GoTerm", "value": "P:non-canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd07066", "properties": [{"key": "EntryName", "value": "CRD_FZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.2030", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "1.10.2000.10", "properties": [{"key": "EntryName", "value": "Frizzled cysteine-rich domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR038081", "properties": [{"key": "EntryName", "value": "CalX-like_sf"}]}, {"database": "InterPro", "id": "IPR003644", "properties": [{"key": "EntryName", "value": "Calx_beta"}]}, {"database": "InterPro", "id": "IPR015526", "properties": [{"key": "EntryName", "value": "Frizzled/SFRP"}]}, {"database": "InterPro", "id": "IPR020067", "properties": [{"key": "EntryName", "value": "Frizzled_dom"}]}, {"database": "InterPro", "id": "IPR036790", "properties": [{"key": "EntryName", "value": "Frizzled_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR11309", "properties": [{"key": "EntryName", "value": "FRIZZLED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11309:SF47", "properties": [{"key": "EntryName", "value": "FRIZZLED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03160", "properties": [{"key": "EntryName", "value": "Calx-beta"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Pfam", "id": "PF01392", "properties": [{"key": "EntryName", "value": "Fz"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00237", "properties": [{"key": "EntryName", "value": "Calx_beta"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00063", "properties": [{"key": "EntryName", "value": "FRI"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF141072", "properties": [{"key": "EntryName", "value": "CalX-like"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SUPFAM", "id": "SSF63501", "properties": [{"key": "EntryName", "value": "Frizzled cysteine-rich domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50038", "properties": [{"key": "EntryName", "value": "FZ"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MQDNRHSQAIIVLLAAVALGHSASQEIECRPRSSKGFCANFAQNVPFYAVPNFRGGSVMSEIEQELGSYKNLVSSGCSNALGHFLCSYYYPPCYQLNFGNTLKTLRLPPCQELCHYVRSSCEPVMARYRRSWPAHLDCSQFPSVCETNLCFPSSNSLQKHQSMQPLSVPGTFVFRYQKGRSFRINDENMVSISVGGRSSATVSEGQAIAVNIALDRPAQYGTTVYVTLDTVEQSARSADYQPGPYTASFYPGQTTTTVFIPTINDEIAENSEAFQISISSINSTHSNIVSCSDTLTVVIADDHDVVTCGFSDTIFESIEGQHSLLTLICTDEHEINFTLQVQTQGVTAVEGEDYSPGPYSVKFEAGQQQAILAIPTVDNSVAELVETFTARIVGSDQMAKVVFGGEAEVSIQDNDVTKCRLAAQNSSTLEGTTASVVVECQGQYDFDCNLQITVVGGSATGADYQLPQLVTLRAGSEQTSFDVVVLSDGIEDDGETVAVCIESIDQPALVLVNESRPSFITIKESTKIFCHEVPQNVSVFEGESARVVVTCSGSLNKDFNLFLDTKDGSATALWKEVSSRGTHGLSCRSSEGRHSRHAAINGIIHRTLSAAGVPSRLEPPGLSRSDGKRPDGVSLVPWSAGRPLVWDATCADTFASSLRGHATRGAGCVAEQAEGRKAGKYAHLAPAYLFQAIAIETSGAIGPSSRSFLKELGRRVAAESGDRRAGSYLLQRLAVAIQRGNAAAVLGCAARS", "length": 752, "molWeight": 80781, "crc64": "51421C7C14E67A7D", "md5": "71DE5B187CC274BC5BCFCA144D4EEAAB"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Disulfide bond": 1}, "uniParcId": "UPI0035D289A7"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9P8M0", "uniProtkbId": "A0AAT9P8M0_SCYPA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Scylla paramamosain", "commonName": "Mud crab", "taxonId": 85552, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UDM59912.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Portunoidea", "Portunidae", "Portuninae", "Scylla"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UDM59912.1"}], "value": "Spamprin"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 87, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C3G53C7VKFSFR", "citationType": "submission", "authors": ["Wang K.", "Zhu X.", "Chen F."], "publicationDate": "JUL-2020", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UDM59912.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "MT707606", "properties": [{"key": "ProteinId", "value": "UDM59912.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSSAHCQTRRTASSPRWSRHRGATPTSQTLTSAGPGECYNRPASLCISLFLLYGKSRRHNSEDIRCIKYENALEKEEPGRRKRMPNGSDSQMQQRH", "length": 96, "molWeight": 10949, "crc64": "D349C84DB7CB05D7", "md5": "DCAC2310CE7EB430555B12364FC88C17"}, "extraAttributes": {"countByFeatureType": {"Region": 2, "Compositional bias": 3}, "uniParcId": "UPI0035D2C1D6"}, "cluster_size": 1, "family": "Portunidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96Y222", "uniProtkbId": "A0AA96Y222_THEDO", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 9, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Thermobia domestica", "commonName": "Firebrat", "synonyms": ["Lepisma domestica"], "taxonId": 89055, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA06339.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Zygentoma", "Lepismatidae", "Thermobia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA06339.1"}], "value": "E93"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00320"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 238, "modifier": "EXACT"}, "end": {"value": 290, "modifier": "EXACT"}}, "description": "HTH psq-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50960"}]}, {"type": "Domain", "location": {"start": {"value": 616, "modifier": "EXACT"}, "end": {"value": 668, "modifier": "EXACT"}}, "description": "HTH psq-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50960"}]}, {"type": "DNA binding", "location": {"start": {"value": 266, "modifier": "EXACT"}, "end": {"value": 286, "modifier": "EXACT"}}, "description": "H-T-H motif", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00320"}]}, {"type": "DNA binding", "location": {"start": {"value": 644, "modifier": "EXACT"}, "end": {"value": 664, "modifier": "EXACT"}}, "description": "H-T-H motif", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00320"}]}, {"type": "Region", "location": {"start": {"value": 84, "modifier": "EXACT"}, "end": {"value": 115, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 175, "modifier": "EXACT"}, "end": {"value": 215, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 291, "modifier": "EXACT"}, "end": {"value": 324, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 424, "modifier": "EXACT"}, "end": {"value": 451, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 555, "modifier": "EXACT"}, "end": {"value": 627, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 663, "modifier": "EXACT"}, "end": {"value": 691, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 873, "modifier": "EXACT"}, "end": {"value": 1010, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 85, "modifier": "EXACT"}, "end": {"value": 115, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 183, "modifier": "EXACT"}, "end": {"value": 197, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 555, "modifier": "EXACT"}, "end": {"value": 573, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 591, "modifier": "EXACT"}, "end": {"value": 600, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 610, "modifier": "EXACT"}, "end": {"value": 622, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 675, "modifier": "EXACT"}, "end": {"value": 691, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 875, "modifier": "EXACT"}, "end": {"value": 884, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 885, "modifier": "EXACT"}, "end": {"value": 898, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 923, "modifier": "EXACT"}, "end": {"value": 942, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 964, "modifier": "EXACT"}, "end": {"value": 975, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 976, "modifier": "EXACT"}, "end": {"value": 994, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 996, "modifier": "EXACT"}, "end": {"value": 1010, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00320"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00320"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4HDCUAAQ3U5PO", "citationType": "submission", "authors": ["Bai Y."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA06339.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR554534", "properties": [{"key": "ProteinId", "value": "WOA06339.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0006357", "properties": [{"key": "GoTerm", "value": "P:regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "1.10.10.60:FF:000019", "properties": [{"key": "EntryName", "value": "Ligand-dependent corepressor isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.10.60", "properties": [{"key": "EntryName", "value": "Homeodomain-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR009057", "properties": [{"key": "EntryName", "value": "Homeodomain-like_sf"}]}, {"database": "InterPro", "id": "IPR007889", "properties": [{"key": "EntryName", "value": "HTH_Psq"}]}, {"database": "PANTHER", "id": "PTHR21545:SF13", "properties": [{"key": "EntryName", "value": "ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21545", "properties": [{"key": "EntryName", "value": "TRANSCRIPTION FACTOR MLR1/2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF05225", "properties": [{"key": "EntryName", "value": "HTH_psq"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF46689", "properties": [{"key": "EntryName", "value": "Homeodomain-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50960", "properties": [{"key": "EntryName", "value": "HTH_PSQ"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MAECSYARCVHERRAIKKELQRWTKNVVYLEGLERVAEELMGKRKWKKYQEIIYNNRGEEPEAHDWEPNSKCCFCEGGGLPDFMSPPSESSQSSRETPPATLPDSAAPSLPPSTTSAVSSLSAFESVTSMAASLAAVAALSSSSSAGATAGTPSSLLYPQFPWYLSPHLGSRYPATKGDTLEVPSSKQEPSLPSTEQPLDLSAKPRSALAEGSSSADRLSSFLRVPDNKHIFKAKPRMSNVAGRRTYTEEELQAALRDIQSGKLGTRRAAVIYGIPRSTLRNKVYKLAMEKERDHQLQKAPDIKREPEEPASEKAGGESEDKKSLSMEDLVKFPGFSASESLRHLLQGRKGGKQNENLAMMYPYREFAGLERSVLGPYISHLLSGNNQDHIKNSAAVLDKSDLSKFPLLPEFVRRMTEERLVEEQKRQQMNGVHSSVGDIPEKREKPRTASVIQSEKLGEMLLSASERGGGTPTSVSASNVILKIPSFKPSKNGVASEETCPSLAKAETVSDVLESSQTMISAGANSGSCSPDLVASKAIGATSVKEVIAKSITQRVQNSENESKVPQTNDDSTAPPLKKPKLGGPPATVASPNSQNNNTAEDKNAQKSKSGKGTRPKRGKYRNYDRDSLVEAVKAVQRGEMSVHRAGSYYGVPHSTLEYKVKERHLMRPRKREAKQQQRLEEKKDDADKKANKLKYPLSATPTVKAKPSVLSPPNNIVSPSSSATTNGLKIPPIFDPTLSPLTYPPFPFWPSAPYLPFEFSQYSAEQFFASQMMQRLQEDARQHEGNPSFKHAKEMAENLYNTSGSSLLDNLIRSSLEMGLPNKPFPDMKLDSFSDGTAPENMSNKALLDQLCKNSHFPPFTSHMLPENLKVQQQHDEGKEKVSSSSTNNNTSSNNSHAIKAEGSSNANPKPSELAEAVDLSRTSASETTFVEESLDSSLDPTDEDVDQSAGEVNGVTNPESACDKKEVDTAKDDEGDDDDEEDEEVVDELEGDTLSTDGTKSNQSHRD", "length": 1010, "molWeight": 110464, "crc64": "FBB8BDF213408B02", "md5": "885C2ABD04D828763A4000194575DC25"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 2, "DNA binding": 2, "Region": 7, "Compositional bias": 12}, "uniParcId": "UPI002B28D9E2"}, "cluster_size": 1, "family": "Lepismatidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BIF8", "uniProtkbId": "A0AAQ5BIF8_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520446.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520446.1"}], "value": "Integrin subunit beta 6"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520446.1"}], "value": "ITGB6"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Single-pass type I membrane protein", "id": "SL-9905"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007449"}], "value": "Belongs to the integrin beta chain family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "Integrin beta subunit VWA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00362"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023037"}], "id": "KW-0401", "category": "Molecular function", "name": "Integrin"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BIF8"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BIF8"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520446.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520446.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15815621", "citationType": "journal article", "authors": ["Hillier L.W.", "Graves T.A.", "Fulton R.S.", "Fulton L.A.", "Pepin K.H.", "Minx P.", "Wagner-McPherson C.", "Layman D.", "Wylie K.", "Sekhon M.", "Becker M.C.", "Fewell G.A.", "Delehaunty K.D.", "Miner T.L.", "Nash W.E.", "Kremitzki C.", "Oddy L.", "Du H.", "Sun H.", "Bradshaw-Cordum H.", "Ali J.", "Carter J.", "Cordes M.", "Harris A.", "Isak A.", "van Brunt A.", "Nguyen C.", "Du F.", "Courtney L.", "Kalicki J.", "Ozersky P.", "Abbott S.", "Armstrong J.", "Belter E.A.", "Caruso L.", "Cedroni M.", "Cotton M.", "Davidson T.", "Desai A.", "Elliott G.", "Erb T.", "Fronick C.", "Gaige T.", "Haakenson W.", "Haglund K.", "Holmes A.", "Harkins R.", "Kim K.", "Kruchowski S.S.", "Strong C.M.", "Grewal N.", "Goyea E.", "Hou S.", "Levy A.", "Martinka S.", "Mead K.", "McLellan M.D.", "Meyer R.", "Randall-Maher J.", "Tomlinson C.", "Dauphin-Kohlberg S.", "Kozlowicz-Reilly A.", "Shah N.", "Swearengen-Shahid S.", "Snider J.", "Strong J.T.", "Thompson J.", "Yoakum M.", "Leonard S.", "Pearman C.", "Trani L.", "Radionenko M.", "Waligorski J.E.", "Wang C.", "Rock S.M.", "Tin-Wollam A.M.", "Maupin R.", "Latreille P.", "Wendl M.C.", "Yang S.P.", "Pohl C.", "Wallis J.W.", "Spieth J.", "Bieri T.A.", "Berkowicz N.", "Nelson J.O.", "Osborne J.", "Ding L.", "Meyer R.", "Sabo A.", "Shotland Y.", "Sinha P.", "Wohldmann P.E.", "Cook L.L.", "Hickenbotham M.T.", "Eldred J.", "Williams D.", "Jones T.A.", "She X.", "Ciccarelli F.D.", "Izaurralde E.", "Taylor J.", "Schmutz J.", "Myers R.M.", "Cox D.R.", "Huang X.", "McPherson J.D.", "Mardis E.R.", "Clifton S.W.", "Warren W.C.", "Chinwalla A.T.", "Eddy S.R.", "Marra M.A.", "Ovcharenko I.", "Furey T.S.", "Miller W.", "Eichler E.E.", "Bork P.", "Suyama M.", "Torrents D.", "Waterston R.H.", "Wilson R.K."], "citationCrossReferences": [{"database": "PubMed", "id": "15815621"}, {"database": "DOI", "id": "10.1038/nature03466"}], "title": "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.", "publicationDate": "2005", "journal": "Nature", "firstPage": "724", "lastPage": "731", "volume": "434"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520446.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520446.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC080166", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AC092153", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BIF8", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000485635.2", "properties": [{"key": "ProteinId", "value": "ENSP00000520446.1"}, {"key": "GeneId", "value": "ENSG00000115221.13"}]}, {"database": "HGNC", "id": "HGNC:6161", "properties": [{"key": "GeneName", "value": "ITGB6"}]}, {"database": "OpenTargets", "id": "ENSG00000115221", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT01140000282512", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 2"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0043235", "properties": [{"key": "GoTerm", "value": "C:receptor complex"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0007155", "properties": [{"key": "GoTerm", "value": "P:cell adhesion"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0007229", "properties": [{"key": "GoTerm", "value": "P:integrin-mediated signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR015812", "properties": [{"key": "EntryName", "value": "Integrin_bsu"}]}, {"database": "InterPro", "id": "IPR002369", "properties": [{"key": "EntryName", "value": "Integrin_bsu_VWA"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR10082", "properties": [{"key": "EntryName", "value": "INTEGRIN BETA SUBUNIT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10082:SF11", "properties": [{"key": "EntryName", "value": "INTEGRIN BETA-6"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00362", "properties": [{"key": "EntryName", "value": "Integrin_beta"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCRLRK", "length": 63, "molWeight": 7064, "crc64": "A59281CF707A5CF4", "md5": "AD6DDC1E1AB2A421246B0EEFEDF5A6FF"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI00024D0EA0"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HFJ5", "uniProtkbId": "A0AA96HFJ5_THRPL", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Thrips palmi", "commonName": "Melon thrips", "taxonId": 161013, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28508.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Thysanoptera", "Terebrantia", "Thripoidea", "Thripidae", "Thrips"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28508.1"}], "value": "Yellow protein"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009127"}], "value": "Belongs to the major royal jelly protein family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28508.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 67, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28508.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-A8QMHI7B7G5F", "citationType": "submission", "authors": ["Shiksha B.", "Amalendu G."], "publicationDate": "JUL-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28508.1"}], "value": "AG-75", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN28508.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR371479", "properties": [{"key": "ProteinId", "value": "WNN28508.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "Gene3D", "id": "2.120.10.30", "properties": [{"key": "EntryName", "value": "TolB, C-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR011042", "properties": [{"key": "EntryName", "value": "6-blade_b-propeller_TolB-like"}]}, {"database": "InterPro", "id": "IPR017996", "properties": [{"key": "EntryName", "value": "MRJP/yellow-related"}]}, {"database": "PANTHER", "id": "PTHR10009", "properties": [{"key": "EntryName", "value": "PROTEIN YELLOW-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10009:SF11", "properties": [{"key": "EntryName", "value": "RH54244P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03022", "properties": [{"key": "EntryName", "value": "MRJP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "EFNPDTNALVASDRETMIFPNDLKVDPKGNVWMLSNRMPIFHYKSLNHKEVNFRFFKANTKELIKGT", "length": 67, "molWeight": 7857, "crc64": "AF4E0CFCD38FBFFA", "md5": "AB2E0925DFD897D3D96DF7616E097D67"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI002B282B8D"}, "cluster_size": 1, "family": "Thripidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PAZ8", "uniProtkbId": "A0AAU6PAZ8_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20557.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20557.1"}], "value": "Venom peptide"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 59, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043458926"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20557.1"}], "value": "U_LCTX_3_Cm25", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20557.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480826", "properties": [{"key": "ProteinId", "value": "WXB20557.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSKYFLLFLSFTLLVQVAHFEHCIERMHLGCIPDSEYEVLKCCAPYTCDWHDGVGRCLE", "length": 59, "molWeight": 6899, "crc64": "61BD8B005F2C6025", "md5": "C8041A5E9A27E6ED5B8A34EB43EF9F1C"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D39593"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU32", "uniProtkbId": "A0AAT9UU32_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41600.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41600.1"}], "value": "Cytochrome P450 4NU1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 430, "modifier": "EXACT"}, "end": {"value": 430, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41600.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117160", "properties": [{"key": "ProteinId", "value": "WIM41600.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd20628", "properties": [{"key": "EntryName", "value": "CYP4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFGVTIFLFVLAFIIYERYSKLKITNLNGPKLIPLIGNGLEFLTNEDALYVLYRMVQKYGNIYRVWLCNDLYIIMTNPKDIEVLLNSYKHIMKAFSYKFVSSWLGNGLITSHGDTWRVHRKLLTPTFHFKILENSIEIIHRNVNILKNSLEREVGSGEFDIHSYIEKCSLDIIIETAMGIKMNVQTSNEAKSYLNAVKSVTNISVSRIFKVWLQPEFFYKMSNYSKIFDESLKQMEDVSKNVITSRRKELLEKTTPTPTSETKNKPFLDFLLTESNFTDDEIHSEVKSFMFAGHDTTTSAICFCIGQIAKHGDVQDKIYDEIIQIFPDGESYANIQNLNKLKYMENVIKETLRLYPTVPMIGRTILEDVVLPSGQKLPANSNINIFIYSIQRNPEIFENPDEFIPERFNDEKLKQYPYAFIPFSAGPRNCIGQRLAMMEIKMTLATLLRSYRLLATKSLHSSTISNDGN", "length": 469, "molWeight": 54143, "crc64": "EF3A37160087EC32", "md5": "131719830C6AF5A19B2C5817E89E025E"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D3A327"}, "cluster_size": 3, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2X9", "uniProtkbId": "A0AA96S2X9_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50029.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50029.1"}], "value": "Deleted in malignant brain tumors 1 protein-like protein 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 1011, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041645280"}, {"type": "Transmembrane", "location": {"start": {"value": 944, "modifier": "EXACT"}, "end": {"value": 965, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 148, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 159, "modifier": "EXACT"}, "end": {"value": 273, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 303, "modifier": "EXACT"}, "end": {"value": 408, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 419, "modifier": "EXACT"}, "end": {"value": 517, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 527, "modifier": "EXACT"}, "end": {"value": 624, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 634, "modifier": "EXACT"}, "end": {"value": 735, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 113, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 377, "modifier": "EXACT"}, "end": {"value": 387, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 442, "modifier": "EXACT"}, "end": {"value": 506, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 455, "modifier": "EXACT"}, "end": {"value": 516, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 486, "modifier": "EXACT"}, "end": {"value": 496, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 595, "modifier": "EXACT"}, "end": {"value": 605, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 705, "modifier": "EXACT"}, "end": {"value": 715, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50029.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460106", "properties": [{"key": "ProteinId", "value": "WNS50029.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "FunFam", "id": "3.10.250.10:FF:000016", "properties": [{"key": "EntryName", "value": "Scavenger receptor cysteine-rich protein type 12"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "Gene3D", "id": "2.10.25.10", "properties": [{"key": "EntryName", "value": "Laminin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.250.10", "properties": [{"key": "EntryName", "value": "SRCR-like domain"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "InterPro", "id": "IPR000742", "properties": [{"key": "EntryName", "value": "EGF-like_dom"}]}, {"database": "InterPro", "id": "IPR001190", "properties": [{"key": "EntryName", "value": "SRCR"}]}, {"database": "InterPro", "id": "IPR036772", "properties": [{"key": "EntryName", "value": "SRCR-like_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR19331", "properties": [{"key": "EntryName", "value": "SCAVENGER RECEPTOR DOMAIN-CONTAINING"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00530", "properties": [{"key": "EntryName", "value": "SRCR"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "PRINTS", "id": "PR00258", "properties": [{"key": "EntryName", "value": "SPERACTRCPTR"}]}, {"database": "SMART", "id": "SM00181", "properties": [{"key": "EntryName", "value": "EGF"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "SMART", "id": "SM00202", "properties": [{"key": "EntryName", "value": "SR"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "SUPFAM", "id": "SSF56487", "properties": [{"key": "EntryName", "value": "SRCR-like"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "PROSITE", "id": "PS00420", "properties": [{"key": "EntryName", "value": "SRCR_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50287", "properties": [{"key": "EntryName", "value": "SRCR_2"}, {"key": "MatchStatus", "value": "6"}]}], "sequence": {"value": "MSRLLAAVVLLLLQLPGVHLQGLGDVRLAGYGATRLGGRVEFFENGEWKGICNDQFGGEDANVICRQLGLGHATKIINQDRDYILKRFLRSRRDYTYNRFGVGPAVRITDLDCNGNETHILNCPFQLNNDVNRFTYCQLHEVVGVQCDNYLPQPYNGQVNLIGGIYPSEGRLAVFFNGRWGGVCREDFDRTNLLGDTICRQLGYTNVDFARINSSGSDLYGPALERTWLDGLSCSGLESSRPVCLKSCLPTRTAPQPSQEVQCNLGQVGLRCVYGFASRNPSLVGTKKSCEVEVGATPSEGDVRLMNGSLPHLGRLEVYLKGVWGTVCGAKSQVNRRVGDVVCRQLGYTSWDTLHHRSSVAGYGSGSGPRHITKLNCTGLEDSILQCRRENATFSPCSDPDILAVQCSNNTNGVVFGAVTMEGGSGGHGQLYVNTEGYTPLCDHTFGLREANVACRQMGYESAIGMVKNSFYGFGRRPAGVTHIQCHGNETHLLECNYRNDTFERCGDSDQIGLQCSSSNDEREGGLRLVNSPDTNSGLVEMFVEGHWNRLCSNLFSETAADVACRQLGFTGSIEVIKDGRFGSTDSGIFIVHQCHGSEESLFDCDHTPIHPNFCQKDIAISCSRASPQEEGAVRLTGGTEVSGRLEVYEYGRWGSVCQNKFDPNEAFVACKQLGFYNYSGFTNSFGRPVREDVKIPINIFSIHCNGTEETLISCDHDVSIRLCNHTLDIILTCAECTKQCQNGGLLDEDICSCNCTHPDYIGTECEVCSISCENGGTPQLDSCTCACPDFYGGDHCGECTKQCQNGGLLDEDICSCNCTHPDYIGTECEVCSISCENGGTPQLDSCTCACPDFYGGDHCGDCVKSCANDGELSIDACSCNCSNSAFSGVTCEECPLFCLNSGILDSTTCSCACTAGFTGSLCHTAKPVSSGLSPAITAGLSTGILLLVVLVILMFSFMAVVYALRRRKQRIEAQTESDWIPATHAENFDINFDNPQFDEDNIEFHKEELF", "length": 1011, "molWeight": 110081, "crc64": "C6C869D1416A22F2", "md5": "220C21F39268CACE372FCC8253C9E036"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 6, "Disulfide bond": 7}, "uniParcId": "UPI002B2E1560"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39CFG0", "uniProtkbId": "A0AB39CFG0_9LILI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Lilium hybrid cultivar", "taxonId": 156531, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDJ26788.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Liliopsida", "Liliales", "Liliaceae", "Lilium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU369065"}], "value": "Protein TIFY"}}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU369065"}], "value": "Jasmonate ZIM domain-containing protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDJ26788.1"}], "value": "JAZ4"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU369065"}], "value": "Repressor of jasmonate responses"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU369065"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU369065"}], "value": "The jas domain is required for interaction with COI1"}], "commentType": "DOMAIN"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008614"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU369065"}], "value": "Belongs to the TIFY/JAZ family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 38, "modifier": "EXACT"}, "end": {"value": 172, "modifier": "EXACT"}}, "description": "Protein TIFY", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044215852"}, {"type": "Domain", "location": {"start": {"value": 62, "modifier": "EXACT"}, "end": {"value": 97, "modifier": "EXACT"}}, "description": "Tify", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51320"}]}, {"type": "Region", "location": {"start": {"value": 152, "modifier": "EXACT"}, "end": {"value": 172, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022819"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU369065"}], "id": "KW-1184", "category": "Biological process", "name": "Jasmonic acid signaling pathway"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU369065"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8R1LMOF2VPRSB", "citationType": "submission", "authors": ["Qianqian F.", "Xue P."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDJ26788.1"}], "value": "Anther", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDJ26788.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ058144", "properties": [{"key": "ProteinId", "value": "XDJ26788.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0031347", "properties": [{"key": "GoTerm", "value": "P:regulation of defense response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:2000022", "properties": [{"key": "GoTerm", "value": "P:regulation of jasmonic acid mediated signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0009611", "properties": [{"key": "GoTerm", "value": "P:response to wounding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "InterPro", "id": "IPR018467", "properties": [{"key": "EntryName", "value": "CCT_CS"}]}, {"database": "InterPro", "id": "IPR040390", "properties": [{"key": "EntryName", "value": "TIFY/JAZ"}]}, {"database": "InterPro", "id": "IPR010399", "properties": [{"key": "EntryName", "value": "Tify_dom"}]}, {"database": "PANTHER", "id": "PTHR33077", "properties": [{"key": "EntryName", "value": "PROTEIN TIFY 4A-RELATED-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR33077:SF90", "properties": [{"key": "EntryName", "value": "PROTEIN TIFY 7"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF09425", "properties": [{"key": "EntryName", "value": "Jas_motif"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF06200", "properties": [{"key": "EntryName", "value": "tify"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00979", "properties": [{"key": "EntryName", "value": "TIFY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51320", "properties": [{"key": "EntryName", "value": "TIFY"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MWCSLFPTRTNAIIPVPCPLAALCLCSFFNLMQPTMGTDAASSGSVVDTEFDSFTPMDVNKQLHTTAQLTIFYNDSLNVYDDVPLDKAQAVMLLASEGLNTSSSAVYQKSVAQTTDALCSVTKLFNTEAAIQARKESLARFLEYRKERITSPTPYTRTKNQAGDSPSTKLQL", "length": 172, "molWeight": 18863, "crc64": "97E248569AAB5900", "md5": "A17AF606E8EC72A4641C03848F78EED9"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "DOMAIN": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1}, "uniParcId": "UPI00388BE424"}, "cluster_size": 1, "family": "Liliaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HCI7", "uniProtkbId": "A0AA96HCI7_9BILA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hemithiris psittacea", "taxonId": 763142, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25253.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Brachiopoda", "Rhynchonelliformea", "Rhynchonellata", "Rhynchonellida", "Hemithiridoidea", "Hemithyrididae", "Hemithiris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25253.1"}], "value": "Hypoxia-inducible factor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Domain", "location": {"start": {"value": 97, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 239, "modifier": "EXACT"}, "end": {"value": 290, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 499, "modifier": "EXACT"}, "end": {"value": 523, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 499, "modifier": "EXACT"}, "end": {"value": 518, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25253.1"}], "value": "Hemi1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25253.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354988", "properties": [{"key": "ProteinId", "value": "WNN25253.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR001610", "properties": [{"key": "EntryName", "value": "PAC"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "InterPro", "id": "IPR013655", "properties": [{"key": "EntryName", "value": "PAS_fold_3"}]}, {"database": "NCBIfam", "id": "TIGR00229", "properties": [{"key": "EntryName", "value": "sensory_box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23171", "properties": [{"key": "EntryName", "value": "bHLH_HIF1A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08447", "properties": [{"key": "EntryName", "value": "PAS_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00086", "properties": [{"key": "EntryName", "value": "PAC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MATIYKEKRRNSDKRREKSRDAARCRRGKETEVFQDLIDILPLSTNVVDCLDKTSVMRLVFSYMQIRTLMGAQDVYPEFSGDHDYDKLYPKALDGVLMLLSSEGDIIYISENVAKHIGIPCIEMMGHSLFDFIHPCDQEELKDALHSKATAKSNGSQIQFFLRLKSTLTRRGRSVNLKSASHKVMKCSGHLLDPSKWVDTKAAIPATLGSVFALIASPIPHPSNVDVPLDGHTFLTRHNMDMTFTYCDDRIEELTGYSPGDLEGKSAFDYHHALDSAQIEKDYKTLFSKGQTMTGVYRFLAKNGGYIWLCTQSTVISNNRTQKPQCVVSVNYVLSGVEEPNAILANVQNIHSLTDKCFVSNCPDKMPRDKDKPVFTSAEDLTYLAPTAGDAYILLPEASAEVDGEFFDDFYDDMFTIGTNPYDDGNAPIGVTNNLLFSPTSEVVKSPVSIEMLDKMADRDTGIFVDDNKMSDDDAMDWEMRAPYAPLDVDDFLLELSDQSSTIETSPQPSIAQTSGDSWRTPPPVMAVPNPLQIDVNTCTSISPPQVSRLATSVFSPGVSTATTGKRCAPPWPLAQRSITRPAPNVGVCRPVVAPIAKPSPPPDVPARKTSFLQQTLLATPPRPSTTKPLPVYGQHREPPVGQKHCLPEDRAYVPPEKKMRTIGYVQGWPKDTVNAMPRLAQMLGHGPAATNQNAGIKERPSVLMSLLSSGQDFNSGYSVKDQVPRLTTKKQSQRLLPLITQNDIEANAPSSYNGLLRGNDLLRALEVYPPS", "length": 772, "molWeight": 85285, "crc64": "237EDC50F4394287", "md5": "683C7FF00563A60BD53077F0BDD0E6B8"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 2, "Compositional bias": 2}, "uniParcId": "UPI002B2C2B66"}, "cluster_size": 1, "family": "Hemithyrididae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8KYS4", "uniProtkbId": "A0AAU8KYS4_SOGFU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Sogatella furcifera", "commonName": "White-backed planthopper", "taxonId": 113103, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN29451.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Auchenorrhyncha", "Fulgoroidea", "Delphacidae", "Delphacinae", "Sogatella"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012663"}], "value": "beta-N-acetylhexosaminidase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012663"}], "value": "3.2.1.52"}]}, "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN29451.1"}], "value": "Hex10"}}], "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "ecNumber": "3.2.1.52", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001231"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006285"}], "value": "Belongs to the glycosyl hydrolase 20 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "Glycoside hydrolase family 20 catalytic", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00728"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN29451.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1T01IF3DUMK1E", "citationType": "submission", "authors": ["Guo P."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN29451.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP965692", "properties": [{"key": "ProteinId", "value": "XCN29451.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004563", "properties": [{"key": "GoTerm", "value": "F:beta-N-acetylhexosaminidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0005975", "properties": [{"key": "GoTerm", "value": "P:carbohydrate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd06565", "properties": [{"key": "EntryName", "value": "GH20_GcnA-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.20.20.80", "properties": [{"key": "EntryName", "value": "Glycosidases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR015883", "properties": [{"key": "EntryName", "value": "Glyco_hydro_20_cat"}]}, {"database": "InterPro", "id": "IPR017853", "properties": [{"key": "EntryName", "value": "Glycoside_hydrolase_SF"}]}, {"database": "InterPro", "id": "IPR038901", "properties": [{"key": "EntryName", "value": "HEXDC-like"}]}, {"database": "PANTHER", "id": "PTHR21040", "properties": [{"key": "EntryName", "value": "BCDNA.GH04120"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21040:SF13", "properties": [{"key": "EntryName", "value": "BETA-N-ACETYLHEXOSAMINIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00728", "properties": [{"key": "EntryName", "value": "Glyco_hydro_20"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF51445", "properties": [{"key": "EntryName", "value": "(Trans)glycosidases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFPYRRVELTARNAYTKSEIAAIQRLAAENQLIVIPLIQTFGHLEFMLKLKEYKNLREEPRYPQVICPSRNASLTLLKEMIDDMLELHPASKYIHIGSDEVYYLGECSQCQERLKKMKWDKRDLFLNHMTTVAKYIKGRRPNLTVLAWDDEFRQMSLEELLSSNVGKLVEPVVWKYTLSIPVDLSLAISEKYAEVFPSIWIASAFKGATGPDMIATDIDYHWRNHVAWMQVVTSLSNTVNVKGIFLTGWQRYDHFSVLCELLPAGFPSLAVNLAYLSSSRLSSGSWPNNKATQALKCDSVEALRKLGAPVRCSFPGAPVFEAVNALVTLRHSYQEMTENSNFRGWFSDYNNEMVFASPSHIEEAFADLGRIKMELSYIRRDVQKAMADVYDPSVYDEWMATHIRPLELKLELWWEAKERLLAKDDWPRRPLKAGEPPVASGQLGLL", "length": 446, "molWeight": 51151, "crc64": "D0255863CB413CCD", "md5": "16C978C678F68DB2DD1207F8DB38E7FB"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D3A833"}, "cluster_size": 1, "family": "Delphacidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEK0", "uniProtkbId": "A0AB38ZEK0_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02714.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012643"}], "value": "5'-nucleotidase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012643"}], "value": "3.1.3.5"}]}, "flag": "Fragment"}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:12484"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:18254"}, {"database": "ChEBI", "id": "CHEBI:43474"}, {"database": "ChEBI", "id": "CHEBI:58043"}], "ecNumber": "3.1.3.5", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00000815"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006654"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362119"}], "value": "Belongs to the 5'-nucleotidase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362119"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 360, "modifier": "EXACT"}}, "description": "5'-nucleotidase", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362119"}], "featureId": "PRO_5044046202"}, {"type": "Domain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 235, "modifier": "EXACT"}}, "description": "Calcineurin-like phosphoesterase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00149"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 360, "modifier": "EXACT"}, "end": {"value": 360, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02714.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362119"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362119"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU362119"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02714.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517464", "properties": [{"key": "ProteinId", "value": "WXI02714.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008253", "properties": [{"key": "GoTerm", "value": "F:5'-nucleotidase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0000166", "properties": [{"key": "GoTerm", "value": "F:nucleotide binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006196", "properties": [{"key": "GoTerm", "value": "P:AMP catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd07409", "properties": [{"key": "EntryName", "value": "MPP_CD73_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.60.21.10:FF:000020", "properties": [{"key": "EntryName", "value": "NT5E isoform 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.60.21.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.90.780.10", "properties": [{"key": "EntryName", "value": "5'-Nucleotidase, C-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036907", "properties": [{"key": "EntryName", "value": "5'-Nucleotdase_C_sf"}]}, {"database": "InterPro", "id": "IPR006146", "properties": [{"key": "EntryName", "value": "5'-Nucleotdase_CS"}]}, {"database": "InterPro", "id": "IPR006179", "properties": [{"key": "EntryName", "value": "5_nucleotidase/apyrase"}]}, {"database": "InterPro", "id": "IPR004843", "properties": [{"key": "EntryName", "value": "Calcineurin-like_PHP"}]}, {"database": "InterPro", "id": "IPR029052", "properties": [{"key": "EntryName", "value": "Metallo-depent_PP-like"}]}, {"database": "PANTHER", "id": "PTHR11575:SF24", "properties": [{"key": "EntryName", "value": "5'-NUCLEOTIDASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11575", "properties": [{"key": "EntryName", "value": "5'-NUCLEOTIDASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00149", "properties": [{"key": "EntryName", "value": "Metallophos"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01607", "properties": [{"key": "EntryName", "value": "APYRASEFAMLY"}]}, {"database": "SUPFAM", "id": "SSF56300", "properties": [{"key": "EntryName", "value": "Metallo-dependent phosphatases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00785", "properties": [{"key": "EntryName", "value": "5_NUCLEOTIDASE_1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTFLQMVLLVTGLVGAALADFELVVIHTNDMHARLDEIAAGGGSCGKSSKCYGGFARIKAAADQVRATRKNVIFLNAGDSFQGSPYYSVYKWEVIAQFVDMLGIDVMSLGNHEFDDGVSGLAPYLRTIKTPTVVCNINYDKEPALLGTNFHRWYSLKVDGTHIAVVGYLTPDTMFLSKTDKVFIMDEVESIRKAASEARAAGAKIVIAVGHSGFDMDRKIAQEVENIDVVVGGHTNTFLYTGDAPDIEVPASVYPHMETQASGKKVPVVQAFAWTKYLGVLHLKFNDKYQLVSASGNPILMDSTKPKDPKVSAKLDYWKNLLNSRTAMHVGTTTVDLDGNCRNKECNLGNMVADALYEYG", "length": 360, "molWeight": 39325, "crc64": "4BA04747CDEA754B", "md5": "F5C332D5DC24DBA26CEE3140003B4B28"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388C1BE9"}, "cluster_size": 2, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39TZ17", "uniProtkbId": "A0AB39TZ17_HUMAN", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84332.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84332.1"}], "value": "Neonatal crystallizable Fc receptor FcRn splice variant 6"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84332.1"}], "value": "FCGRT"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 25, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044251970"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84332.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "38607033", "citationType": "journal article", "authors": ["Haddad G.", "Blaine J."], "citationCrossReferences": [{"database": "PubMed", "id": "38607033"}], "title": "Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.", "publicationDate": "2024", "journal": "Cells", "firstPage": "0", "lastPage": "0", "volume": "13"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84332.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FV12BRJLLL9E9", "citationType": "submission", "authors": ["Haddad G.", "Blaine J."], "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84332.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ136867", "properties": [{"key": "ProteinId", "value": "XDQ84332.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MGVPRPQPWALGLLLFLLPGSLGAAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA", "length": 60, "molWeight": 6203, "crc64": "EC2586188C8670AC", "md5": "1DC3B6EE05E53CE09BF4070DC31E3DA3"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BEB76"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTR8", "uniProtkbId": "A0AAT9UTR8_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41646.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41646.1"}], "value": "Cytochrome P450 15A1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 435, "modifier": "EXACT"}, "end": {"value": 435, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41646.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117206", "properties": [{"key": "ProteinId", "value": "WIM41646.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016712", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008395", "properties": [{"key": "GoTerm", "value": "F:steroid hydroxylase activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006082", "properties": [{"key": "GoTerm", "value": "P:organic acid metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006805", "properties": [{"key": "GoTerm", "value": "P:xenobiotic metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd20651", "properties": [{"key": "EntryName", "value": "CYP15A1-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000036", "properties": [{"key": "EntryName", "value": "CYtochrome P450 family"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050182", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_fam2"}]}, {"database": "PANTHER", "id": "PTHR24300:SF376", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 15A1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24300", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 508A4-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLLCFAIIVVFIVYSLVFINKKPKNYPPGPSWIPFLGCYLQIQNIHSSSKYYHLVWAHLQRLYGSVIGLKLGTKKMVIVSGYEAVQQMLLKKDFEGRPDGFCYRLRTLGERLGVVFVEGSFMREQRRFCMYQLRQFGWGTNTMNDVVTKEALEVVNLIMSAHQQGPIKVQQLFDVSTLNTIWTMIAGHRFSLNDKKLRKLVHLVHKGFRLVDMSGGALNQMPFLRFVAPELSGYNSLKAIITEMMDFLKEVVKKHQEFQGNNFINTFLQEVKNNENNKNSTFTENQLLVLLEDFFMAGTETTSNTLSFVIFYLIKYPEVQKKIHIELDKAFERNQVPSMDDRDKLVYLEATIMEVQRISNPVPIGIPRKAMQDAQLLNYTIPKDTFILPSLWSVHMDEDYWKDPYAFRPERFLNQEGKLIQDPHLIPFGLGKRRCIGEILAKTTLFLFISILLHNFKVEHNLGKDFSVEVLDGVTQTLAPFEVKFIPRK", "length": 489, "molWeight": 56672, "crc64": "BE92AC8B92275C7A", "md5": "419D01F1638DBA6EE2B20FD477C1FB37"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D3CC17"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTL6", "uniProtkbId": "A0AAT9UTL6_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41670.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41670.1"}], "value": "Cytochrome P450 - CYP3636A1 short isoform"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003690"}], "value": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides"}], "commentType": "FUNCTION"}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 153, "modifier": "EXACT"}, "end": {"value": 170, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 413, "modifier": "EXACT"}, "end": {"value": 445, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41670.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41670.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117230", "properties": [{"key": "ProteinId", "value": "WIM41670.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292:SF84", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 28A5-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VSEHIYFHMRKLAFDFTMLSPLYLTAFTIVLFFFTIYLYLKSRYRYWKIRNIPYLEPSLLLGNANDLILGRQSILEFQKCIYDIAKHHKLLGTFMFQKPTLYVTELNWIKLILGRDSGHFFDRGLKFDSAEEPLTRHLFHLEGEEYRSVKDKVMPAFTLNGILILFPLLLESALNLQDYFGKVAETTVDIDVKSVMSRYAAEVIGKCAFGLKKGPLTGDNEEFYKMSKKIFLPRLRTIVKLILPNLPSFVTELFDIKMISTEISEYFSAIIRKEIEYRRQNNKRPSDFLSYMIDVQDKDKEDCLDAQPLTDDIVAAHCFMLFIAAYENTTVVLCAALFELSRHPEVQERLYQEIRDTCYTNGTFDLTMTKISKMTYLHMVVCGKNHSSSQIPQVFLTLTIYRNSPSLPSCHRYDPRMHRGLPNPRNRFPHRQRYTTGDSFCRHAQ", "length": 445, "molWeight": 52054, "crc64": "47FA8047ED4E41D6", "md5": "4337585C2B6A3487E1037127A83E7458"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 2, "Region": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D3048F"}, "cluster_size": 3, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA95Z9R2", "uniProtkbId": "A0AA95Z9R2_9CUCU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Anthonomus eugenii", "commonName": "pepper weevil", "taxonId": 122869, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96198.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Coleoptera", "Polyphaga", "Cucujiformia", "Curculionidae", "Curculioninae", "Anthonomini", "Anthonomus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96198.1"}], "value": "Chemosensory protein 1"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96198.1"}], "value": "CSP1"}}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 14, "modifier": "EXACT"}, "end": {"value": 31, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96198.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DHPI8O2N9J4MB", "citationType": "submission", "authors": ["Segura Leon O.L.", "Lechuga-Paredes P.", "Cibrian Tovar J.", "Torres Huerta B."], "publicationDate": "JUL-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96198.1"}]}, {"referenceNumber": 2, "citation": {"id": "36834814", "citationType": "journal article", "authors": ["Lechuga-Paredes P.", "Segura-Leon O.L.", "Cibrian-Tovar J.", "Torres-Huerta B.", "Velazquez-Gonzalez J.C.", "Cruz-Jaramillo J.L."], "citationCrossReferences": [{"database": "PubMed", "id": "36834814"}], "title": "Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.", "publicationDate": "2023", "journal": "Int. J. Mol. Sci.", "firstPage": "0", "lastPage": "0", "volume": "24"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH96198.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP056795", "properties": [{"key": "ProteinId", "value": "WNH96198.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.10.2080.10", "properties": [{"key": "EntryName", "value": "Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005055", "properties": [{"key": "EntryName", "value": "A10/PebIII"}]}, {"database": "InterPro", "id": "IPR036682", "properties": [{"key": "EntryName", "value": "OS_D_A10/PebIII_sf"}]}, {"database": "PANTHER", "id": "PTHR11257", "properties": [{"key": "EntryName", "value": "CHEMOSENSORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11257:SF12", "properties": [{"key": "EntryName", "value": "EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03392", "properties": [{"key": "EntryName", "value": "OS-D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF100910", "properties": [{"key": "EntryName", "value": "Chemosensory protein Csp2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "APCPTIYQVKMKQFIATFFLIVATIAIIATGEEYSSKYDNIDVDEILHSERLLKNYMNCLLDKGRCTPAGQDLKDNLPDGLENGCKKCSFRKRL", "length": 94, "molWeight": 10647, "crc64": "3267113401B9BCBE", "md5": "1E11E483ECB8A56CEBED5A4BB5473280"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 1}, "uniParcId": "UPI002B306BCA"}, "cluster_size": 1, "family": "Curculionidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA95FJP1", "uniProtkbId": "A0AA95FJP1_ANASP", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Anabrus simplex", "commonName": "Mormon cricket", "taxonId": 316456, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WEU54035.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Polyneoptera", "Orthoptera", "Ensifera", "Tettigoniidea", "Tettigonioidea", "Tettigoniidae", "Tettigoniinae", "Anabrus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WEU54035.1"}], "value": "DsRNase 2"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010052"}], "value": "Belongs to the DNA/RNA non-specific endonuclease family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 404, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041668131"}, {"type": "Domain", "location": {"start": {"value": 147, "modifier": "EXACT"}, "end": {"value": 387, "modifier": "EXACT"}}, "description": "DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00892"}]}, {"type": "Domain", "location": {"start": {"value": 175, "modifier": "EXACT"}, "end": {"value": 363, "modifier": "EXACT"}}, "description": "ENPP1-3/EXOG-like endonuclease/phosphodiesterase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00477"}]}, {"type": "Active site", "location": {"start": {"value": 235, "modifier": "EXACT"}, "end": {"value": 235, "modifier": "EXACT"}}, "description": "Proton acceptor", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR640255-1"}]}, {"type": "Binding site", "location": {"start": {"value": 265, "modifier": "EXACT"}, "end": {"value": 265, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR640255-2"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022759"}], "id": "KW-0255", "category": "Molecular function", "name": "Endonuclease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022759"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR640255-2"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022722"}], "id": "KW-0540", "category": "Molecular function", "name": "Nuclease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8NG76MHSCQP11", "citationType": "submission", "authors": ["Song H."], "publicationDate": "MAR-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WEU54035.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ683315", "properties": [{"key": "ProteinId", "value": "WEU54035.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "RefSeq", "id": "XP_067008540.2", "properties": [{"key": "NucleotideSequenceId", "value": "XM_067152439.2"}]}, {"database": "GeneID", "id": "136878876", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0005743", "properties": [{"key": "GoTerm", "value": "C:mitochondrial inner membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003676", "properties": [{"key": "GoTerm", "value": "F:nucleic acid binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004521", "properties": [{"key": "GoTerm", "value": "F:RNA endonuclease activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000014", "properties": [{"key": "GoTerm", "value": "F:single-stranded DNA endodeoxyribonuclease activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0006309", "properties": [{"key": "GoTerm", "value": "P:apoptotic DNA fragmentation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "3.40.570.10:FF:000007", "properties": [{"key": "EntryName", "value": "Alkaline nuclease"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.570.10", "properties": [{"key": "EntryName", "value": "Extracellular Endonuclease, subunit A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR044929", "properties": [{"key": "EntryName", "value": "DNA/RNA_non-sp_Endonuclease_sf"}]}, {"database": "InterPro", "id": "IPR001604", "properties": [{"key": "EntryName", "value": "Endo_G_ENPP1-like_dom"}]}, {"database": "InterPro", "id": "IPR020821", "properties": [{"key": "EntryName", "value": "ENPP1-3/EXOG-like_nuc-like"}]}, {"database": "InterPro", "id": "IPR044925", "properties": [{"key": "EntryName", "value": "His-Me_finger_sf"}]}, {"database": "InterPro", "id": "IPR040255", "properties": [{"key": "EntryName", "value": "Non-specific_endonuclease"}]}, {"database": "PANTHER", "id": "PTHR13966", "properties": [{"key": "EntryName", "value": "ENDONUCLEASE RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR13966:SF19", "properties": [{"key": "EntryName", "value": "NUCLEASE EXOG, MITOCHONDRIAL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01223", "properties": [{"key": "EntryName", "value": "Endonuclease_NS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00892", "properties": [{"key": "EntryName", "value": "Endonuclease_NS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00477", "properties": [{"key": "EntryName", "value": "NUC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54060", "properties": [{"key": "EntryName", "value": "His-Me finger endonucleases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAPVLFFLLVTTISLAHGFRLQSAGCQVDINEDLAEPQPLLIQPGGALDVTGFLQPNEKGIVYLTSGQKVIVACSGTDNYLSPFSEELAQVTATCVSGTTFTINNKRYELSDVVCSFKPSHNAFATGNKCYGNNIEIYIGFNVSRAFYKTIDVCFDQKLLGPLYSHTTVVAGIGGYETGVDRADFKPAGFYGSVSPESQFKRASEISTIGKLLGSADLGKKYISNTNDYFLARGHLAAKADFVFGNQHRATFYYVNVAPQWQTFNGGNWAVLEQDVRQLASDRGVDLEVYTGTHGIATLPDVNGNDTPLYLHADGMMPIPQFFWKVVYLSQSRAAVAFVGINNPYVRISQHPELILCPDVSDEIGWVSWDPKSVKRGEGYICEVAALRKMVPSIPNISVNKLLT", "length": 404, "molWeight": 44203, "crc64": "67551501278071F5", "md5": "D910F74E171DE79862FD80FF723E36A9"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2, "Active site": 1, "Binding site": 1}, "uniParcId": "UPI002B307785"}, "cluster_size": 1, "family": "Tettigoniidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8L099", "uniProtkbId": "A0AAU8L099_HALDU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28586.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28586.1"}], "value": "Importin-9"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 102, "modifier": "EXACT"}}, "description": "Importin N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50166"}]}, {"type": "Region", "location": {"start": {"value": 907, "modifier": "EXACT"}, "end": {"value": 935, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 916, "modifier": "EXACT"}, "end": {"value": 935, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EGAS7BV8JDS8L", "citationType": "submission", "authors": ["Mikhailov K.", "Kravchuk O.", "Lyupina Y.", "Adameyko K."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28586.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP971920", "properties": [{"key": "ProteinId", "value": "XCN28586.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005829", "properties": [{"key": "GoTerm", "value": "C:cytosol"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005635", "properties": [{"key": "GoTerm", "value": "C:nuclear envelope"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0031267", "properties": [{"key": "GoTerm", "value": "F:small GTPase binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006606", "properties": [{"key": "GoTerm", "value": "P:protein import into nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.25.10.10", "properties": [{"key": "EntryName", "value": "Leucine-rich Repeat Variant"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR011989", "properties": [{"key": "EntryName", "value": "ARM-like"}]}, {"database": "InterPro", "id": "IPR016024", "properties": [{"key": "EntryName", "value": "ARM-type_fold"}]}, {"database": "InterPro", "id": "IPR013598", "properties": [{"key": "EntryName", "value": "Exportin-1/Importin-b-like"}]}, {"database": "InterPro", "id": "IPR001494", "properties": [{"key": "EntryName", "value": "Importin-beta_N"}]}, {"database": "PANTHER", "id": "PTHR10997", "properties": [{"key": "EntryName", "value": "IMPORTIN-7, 8, 11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10997:SF9", "properties": [{"key": "EntryName", "value": "IMPORTIN-9"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03810", "properties": [{"key": "EntryName", "value": "IBN_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08389", "properties": [{"key": "EntryName", "value": "Xpo1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00913", "properties": [{"key": "EntryName", "value": "IBN_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48371", "properties": [{"key": "EntryName", "value": "ARM repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50166", "properties": [{"key": "EntryName", "value": "IMPORTIN_B_NT"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGDLTAVVLDRLEAVAGGDPGLLRKSEDELRALEVSDSYGVVLAEITSRVELAVHVRQLSSLVLKQYVQSHWSREGELFADTLVSGPAKQAIKKHLLGCLASEESKIRATVAYAIAAIATWEWPEEWPEFIDTILAGIHSANPFLVNGSMHVLEEFSSDVSDNQLPKLAPILIPELFQVVSKETYDLRTRCRAVTIFESLTSMVLIVADIYPEVKGFLQPWVDQYLAVFSALLAAHCSLQDLQLLPLLRDILSSVTQLLTAFPGHMSPRVASVLQPAWALLLTCQPLYLQHCVNGLAELPTLEGMLFVLFDFISALVELRSLQKALLPALPQLLHLLISYISITDTQLILWDDEAVKFLEDENDDLYSNSLRMSALDLVNSVASTNRLAGPAMQALVVAINKHLEEAEVAKQQGLQHWWKSHEACMVVMPVLAGGVSEGRVQYDLQQVVLQLALPHMMTEGVHPLLTGRCLWLCGKLVSAISPEVLPRCFSGCVTGIRGDQHMLIRICAVIAAHDMSLGLVDSAHLHVMAPFAEALLVGILELVRLDLDGIRIQVLEALGVLVAVAKEAVCQKSDQIVELCCQVFVKCCNDPGVLTVLEEVFSSLAQQPSCQAAILEGFASLVVKVLQPVGQSGSGTGLVAAMLDIWTQVVLHCPAPLAPPTVEVVYPAIVGALLKVDDSAILQSGGDCLKAYLTKGVEQLGAWSTTSGSSGLLLAVEVILHLLDPAHSEFSCSFLGPLAIVLIKQVGAVLGEHLESVVRSLLSKLHTVQSTAVTQSLLSVLCYLVHTQLASTLDFLEQVPDMSGRSALQFFLLLWTGKHDSFFGKWDTRLSSSGLAALILHYMTTGDPRLGCLETEGEEFGGDNRGIVTRSMKKAGKVEYRRITVPQKMVKLLIDDYQVALESAAGGGGAGGGAEWEDDSDGDEDEEGEGEEDLYSSLLGGDLNALCELESEGTEFSDDPLMQVDWKSYLEDVLIKCCQAERFSEILPALMEPELQTLRSLSKP", "length": 1005, "molWeight": 109198, "crc64": "4558EA56E4727E1E", "md5": "E6A19E8146C62679FA5FDF8279ADF037"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D27443"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZED6", "uniProtkbId": "A0AB38ZED6_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71781.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71781.1"}], "value": "Venom S1 protease 39"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 90, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71781.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71781.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022825"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71781.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510856", "properties": [{"key": "ProteinId", "value": "WXH71781.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR050127", "properties": [{"key": "EntryName", "value": "Serine_Proteases_S1"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24264:SF54", "properties": [{"key": "EntryName", "value": "PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24264", "properties": [{"key": "EntryName", "value": "TRYPSIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGWGLILDKSEGGKASAELRHVNLRVIDPDVCKVIYGIDTLQLTQICTYNNEKDSCQGDSGGPLVHEENGRYVQVALVSYGRKCGSTDPA", "length": 90, "molWeight": 9755, "crc64": "CFD7741B156F5052", "md5": "41F8F4419EDAE6885E0B28D861F33632"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388C0122"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N5Y7", "uniProtkbId": "A0AAN0N5Y7_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34106.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34106.1"}], "value": "Epithelial sodium channel/degenerin-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007193"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "value": "Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 48, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 797, "modifier": "EXACT"}, "end": {"value": 824, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 843, "modifier": "EXACT"}, "end": {"value": 887, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 811, "modifier": "EXACT"}, "end": {"value": 821, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 843, "modifier": "EXACT"}, "end": {"value": 853, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 854, "modifier": "EXACT"}, "end": {"value": 881, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023053"}], "id": "KW-0915", "category": "Ligand", "name": "Sodium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022461"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0894", "category": "Molecular function", "name": "Sodium channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023201"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0739", "category": "Biological process", "name": "Sodium transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34106.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155032", "properties": [{"key": "ProteinId", "value": "WRW34106.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0015280", "properties": [{"key": "GoTerm", "value": "F:ligand-gated sodium channel activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.60.470.10", "properties": [{"key": "EntryName", "value": "Acid-sensing ion channels like domains"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.770", "properties": [{"key": "EntryName", "value": "YojJ-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001873", "properties": [{"key": "EntryName", "value": "ENaC"}]}, {"database": "InterPro", "id": "IPR020903", "properties": [{"key": "EntryName", "value": "ENaC_CS"}]}, {"database": "PANTHER", "id": "PTHR11690", "properties": [{"key": "EntryName", "value": "AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11690:SF248", "properties": [{"key": "EntryName", "value": "PICKPOCKET 17, ISOFORM A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00858", "properties": [{"key": "EntryName", "value": "ASC"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR01078", "properties": [{"key": "EntryName", "value": "AMINACHANNEL"}]}, {"database": "PROSITE", "id": "PS01206", "properties": [{"key": "EntryName", "value": "ASC"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKSNLIDLFKKSSIPGFSNLFSAKSLLRKLLWLIVILTFIYLTSHSLLEIISEYIQFPITVNVLISESRVLKFPAVTVCNLNPVHKTRFCESKNLKKPENIEKILCASLDSLMEVCNVYKLLDDLVGEGEIICKGIDNKKTSNKRKPNRTTVVKKKPNRINCNIRNLTEQNKNDLLSNFYTLNNSIDEEQFINKCADYLLEIDDDEKLKHFPDFKRQKRQINIRSIFKVLRALSTGQFNSFSEILSVFGITGESEAFFDNIIVQLAKLAKLKINSTQDLIPALFLKSFSDSTGCQIGVTSSTTTGPNKIHLALRNLTKAFTNPKCLLKLPKLFELFSKQSHDLMENISKCTSSWVLSLLKEEYSVDESSNLFDVNNMNLTSMKKTMENSWLVLLDILRLWLAELGKMNFEEAVKIGHRKKDLINSCHFAGKKCDIEKDFTSFFFSQYGNCYTYNLHLPQKENFEDEITPHDVLHEENDASLSGFTGPQFGLELILNLETDEYMPTTREIGAKIMVHDTKKRANPEEDSVQIQPGVVTYIGIQMINISREKAPYTDKCSDEWPTKEQFLWAKSLNHNGYTTQVCLKLCLQYHTIKSCGCWTLSAPWPQDDKTPICNTRKNKTITKCTSDVRRQYYNEEIQCNCPPRCSEEIYEKFVSTGKESRQCSALSANGEDVEEQSDEAGNFAKLIIFYQSLTFNTIKQAPKYTAESLIGAVGGILGVYLGFSFLAIYEFLEVLIRSGFLICSKNNEEKSNSAKSNNSLNNRIYNIESNVDDNSSNFQVPTIIVDKLQQNSSSNIKKRIKNYDNTRENSVSSSIDSNTSLKNNSEKDLNIVSAKTFHTTKSFNTSKNTNKYSNKDKISEKSSERSSDKNSDKNSDKNSEKSSNSYLENYEKDSNEEHKLNLNQQDVEKISLETEESEISYEKNDEIKPTNCLQKKIECFKKNMQDCKSIKEFEKIKNELTGKNLIQHSLNALDFNHDKNETNKINDSKMHLNTIYNRFIKCKNNVLKSPELREKKNRWVKIIKDYEF", "length": 1029, "molWeight": 117996, "crc64": "9F465185CE450FCF", "md5": "09B21E6A88E4F28E2C81728CBE83FD5A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Region": 2, "Compositional bias": 3}, "uniParcId": "UPI00324ADB66"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NMJ7", "uniProtkbId": "A0AA96NMJ7_9CRUS", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Paraplatyarthrus sp", "taxonId": 3079294, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00131.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Peracarida", "Isopoda", "Oniscidea", "Crinocheta", "Paraplatyarthridae", "Paraplatyarthrus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012601"}], "value": "cellulase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012601"}], "value": "3.2.1.4"}]}, "flag": "Fragment"}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.", "ecNumber": "3.2.1.4", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00000966"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007072"}], "value": "Belongs to the glycosyl hydrolase 9 (cellulase E) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 119, "modifier": "EXACT"}}, "description": "cellulase", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041659067"}, {"type": "Domain", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 119, "modifier": "EXACT"}}, "description": "Glycoside hydrolase family 9", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00759"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00131.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 119, "modifier": "EXACT"}, "end": {"value": 119, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00131.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023277"}], "id": "KW-0119", "category": "Biological process", "name": "Carbohydrate metabolism"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023001"}], "id": "KW-0136", "category": "Biological process", "name": "Cellulose degradation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023295"}], "id": "KW-0326", "category": "Molecular function", "name": "Glycosidase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023326"}], "id": "KW-0624", "category": "Biological process", "name": "Polysaccharide degradation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "37780085", "citationType": "journal article", "authors": ["Javidkar M.", "Cooper S.J.B.", "Shokri Bousjein N.", "Humphreys W.F.", "King R.A.", "Austin A.D."], "citationCrossReferences": [{"database": "PubMed", "id": "37780085"}], "title": "Evolution of endoglucanase genes in subterranean and surface isopod crustaceans from Central Western Australia.", "publicationDate": "2023", "journal": "Ecol. Evol.", "firstPage": "0", "lastPage": "0", "volume": "13"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00131.1"}], "value": "NODE_20685", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00131.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-1O3KGA4J1ARN2", "citationType": "submission", "authors": ["Javidkar M."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00131.1"}], "value": "NODE_20685", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNU00131.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR531531", "properties": [{"key": "ProteinId", "value": "WNU00131.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004553", "properties": [{"key": "GoTerm", "value": "F:hydrolase activity, hydrolyzing O-glycosyl compounds"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0030245", "properties": [{"key": "GoTerm", "value": "P:cellulose catabolic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.50.10.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008928", "properties": [{"key": "EntryName", "value": "6-hairpin_glycosidase_sf"}]}, {"database": "InterPro", "id": "IPR012341", "properties": [{"key": "EntryName", "value": "6hp_glycosidase-like_sf"}]}, {"database": "InterPro", "id": "IPR001701", "properties": [{"key": "EntryName", "value": "Glyco_hydro_9"}]}, {"database": "PANTHER", "id": "PTHR22298", "properties": [{"key": "EntryName", "value": "ENDO-1,4-BETA-GLUCANASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00759", "properties": [{"key": "EntryName", "value": "Glyco_hydro_9"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48208", "properties": [{"key": "EntryName", "value": "Six-hairpin glycosidases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "TDTVKAMMKSVLITFTLVGIISFAGVAKGQDGGCSATGQTPYDYSQALCMSILFYDAQRSGALNGNERFDWRGDSALTDGQDVGHDLTGGYYDAGDFVKFGLPMAYTVTLLAYSLLSYP", "length": 119, "molWeight": 12734, "crc64": "EA597F95EAFDF1B4", "md5": "AC7409DC86D05D41A22EA99CD4DB58F8"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2B5C93"}, "cluster_size": 1, "family": "Paraplatyarthridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BGM8", "uniProtkbId": "A0AAQ5BGM8_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518973.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518973.1"}], "value": "Bone morphogenetic protein receptor type 1A"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518973.1"}], "value": "BMPR1A"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001946"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}]}, {"commentType": "COFACTOR", "cofactors": [{"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001936"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004370"}], "value": "Membrane", "id": "SL-0162"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 203, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043020995"}, {"type": "Transmembrane", "location": {"start": {"value": 153, "modifier": "EXACT"}, "end": {"value": 176, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 59, "modifier": "EXACT"}, "end": {"value": 132, "modifier": "EXACT"}}, "description": "Activin types I and II receptor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01064"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022842"}], "id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BGM8"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BGM8"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518973.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15164054", "citationType": "journal article", "authors": ["Deloukas P.", "Earthrowl M.E.", "Grafham D.V.", "Rubenfield M.", "French L.", "Steward C.A.", "Sims S.K.", "Jones M.C.", "Searle S.", "Scott C.", "Howe K.", "Hunt S.E.", "Andrews T.D.", "Gilbert J.G.", "Swarbreck D.", "Ashurst J.L.", "Taylor A.", "Battles J.", "Bird C.P.", "Ainscough R.", "Almeida J.P.", "Ashwell R.I.", "Ambrose K.D.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Bates K.", "Beasley H.", "Bray-Allen S.", "Brown A.J.", "Brown J.Y.", "Burford D.C.", "Burrill W.", "Burton J.", "Cahill P.", "Camire D.", "Carter N.P.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.M.", "Clegg S.", "Corby N.", "Coulson A.", "Dhami P.", "Dutta I.", "Dunn M.", "Faulkner L.", "Frankish A.", "Frankland J.A.", "Garner P.", "Garnett J.", "Gribble S.", "Griffiths C.", "Grocock R.", "Gustafson E.", "Hammond S.", "Harley J.L.", "Hart E.", "Heath P.D.", "Ho T.P.", "Hopkins B.", "Horne J.", "Howden P.J.", "Huckle E.", "Hynds C.", "Johnson C.", "Johnson D.", "Kana A.", "Kay M.", "Kimberley A.M.", "Kershaw J.K.", "Kokkinaki M.", "Laird G.K.", "Lawlor S.", "Lee H.M.", "Leongamornlert D.A.", "Laird G.", "Lloyd C.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "McLaren S.", "McLay K.E.", "McMurray A.", "Mashreghi-Mohammadi M.", "Matthews L.", "Milne S.", "Nickerson T.", "Nguyen M.", "Overton-Larty E.", "Palmer S.A.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phillimore B.", "Porter K.", "Rice C.M.", "Rogosin A.", "Ross M.T.", "Sarafidou T.", "Sehra H.K.", "Shownkeen R.", "Skuce C.D.", "Smith M.", "Standring L.", "Sycamore N.", "Tester J.", "Thorpe A.", "Torcasso W.", "Tracey A.", "Tromans A.", "Tsolas J.", "Wall M.", "Walsh J.", "Wang H.", "Weinstock K.", "West A.P.", "Willey D.L.", "Whitehead S.L.", "Wilming L.", "Wray P.W.", "Young L.", "Chen Y.", "Lovering R.C.", "Moschonas N.K.", "Siebert R.", "Fechtel K.", "Bentley D.", "Durbin R.", "Hubbard T.", "Doucette-Stamm L.", "Beck S.", "Smith D.R.", "Rogers J."], "citationCrossReferences": [{"database": "PubMed", "id": "15164054"}, {"database": "DOI", "id": "10.1038/nature02462"}], "title": "The DNA sequence and comparative analysis of human chromosome 10.", "publicationDate": "2004", "journal": "Nature", "firstPage": "375", "lastPage": "381", "volume": "429"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518973.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518973.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518973.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC021036", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AC025268", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AC067750", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BGM8", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000713671.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518973.1"}, {"key": "GeneId", "value": "ENSG00000107779.16"}]}, {"database": "HGNC", "id": "HGNC:1076", "properties": [{"key": "GeneName", "value": "BMPR1A"}]}, {"database": "OpenTargets", "id": "ENSG00000107779", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000156225", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 10"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004675", "properties": [{"key": "GoTerm", "value": "F:transmembrane receptor protein serine/threonine kinase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23612", "properties": [{"key": "EntryName", "value": "TFP_LU_ECD_BMPR1A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.10.60.10:FF:000001", "properties": [{"key": "EntryName", "value": "Receptor protein serine/threonine kinase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.10.60.10", "properties": [{"key": "EntryName", "value": "CD59"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000472", "properties": [{"key": "EntryName", "value": "Activin_recp"}]}, {"database": "InterPro", "id": "IPR045860", "properties": [{"key": "EntryName", "value": "Snake_toxin-like_sf"}]}, {"database": "Pfam", "id": "PF01064", "properties": [{"key": "EntryName", "value": "Activin_recp"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57302", "properties": [{"key": "EntryName", "value": "Snake toxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKFKRYSCLSLASNWDYRATYTFHCGVS", "length": 203, "molWeight": 22805, "crc64": "C7C569A207A291DB", "md5": "955C7FBC2DA4C62F62A1FCEECD459B65"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 2, "SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 1, "Domain": 1}, "uniParcId": "UPI0032CF3B6F"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QP44", "uniProtkbId": "A0AAU0QP44_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56481.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56481.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 16, "modifier": "EXACT"}, "end": {"value": 35, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 82, "modifier": "EXACT"}, "end": {"value": 104, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56481.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 109, "modifier": "EXACT"}, "end": {"value": 109, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56481.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56481.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56481.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56481.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970374", "properties": [{"key": "ProteinId", "value": "WPO56481.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "NILISNYTRYCRKITIFYWSLMYTTVVIVIFQPIFKYSLSPVYRENVKMGNDTYLQVVSSWLPFNKNTIPGYLVASVYQSYAAIYGGGWITSFDSHAMVIMVFFRTELG", "length": 109, "molWeight": 12684, "crc64": "1362CF16AA1A8C59", "md5": "6AC98FC253D2B65A472A9DA507039760"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 2}, "uniParcId": "UPI00308CB8AE"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MKH4", "uniProtkbId": "A0AA96MKH4_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50038.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50038.1"}], "value": "Uncharacterized protein 4"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 90, "modifier": "EXACT"}, "end": {"value": 110, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 156, "modifier": "EXACT"}, "end": {"value": 183, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50038.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460115", "properties": [{"key": "ProteinId", "value": "WNS50038.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MYYRSCPCPGVCCGVVFVQDALAIVTVVREVPPTTSKDRGGRRHLRLTTANKNIGSPAVRVGPSVAWLWSGDADSEQEHRKEMKKLGCRLSPLSAGVIGVLLSFSCVSVAQTACNVTSCLQSGGVDRYGEFRDTCCRYFETDSCCSHAENSAFDLYFYLALGLSIAMFVIIAVILVIIVAVCCQICNCCRCYRHKNY", "length": 197, "molWeight": 21575, "crc64": "11725905D1B949C8", "md5": "B53F22F634E7DEA91112A0085B084900"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 2}, "uniParcId": "UPI002B30A688"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAE8Y3R2", "uniProtkbId": "A0AAE8Y3R2_9ADEN", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "reindeer adenovirus 1", "taxonId": 2885353, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UDF05962.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001264104"}], "lineage": ["Viruses", "Varidnaviria", "Bamfordvirae", "Preplasmiviricota", "Tectiliviricetes", "Rowavirales", "Adenoviridae", "Mastadenovirus", "Mastadenovirus tarandri"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Pre-histone-like nucleoprotein"}}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Pre-core protein VII"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "pVII"}]}], "contains": [{"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Histone-like nucleoprotein"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "NP"}]}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Core protein VII"}}]}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "L2"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus"}], "commentType": "FUNCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response"}], "commentType": "SUBUNIT"}, {"commentType": "SUBCELLULAR LOCATION", "molecule": "Histone-like nucleoprotein", "note": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion"}]}, "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Virion", "id": "SL-0274"}}]}, {"commentType": "SUBCELLULAR LOCATION", "molecule": "Pre-histone-like nucleoprotein", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Host nucleus, host nucleolus", "id": "SL-0412"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Expressed in the late phase of the viral replicative cycle"}], "commentType": "INDUCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein"}], "commentType": "PTM"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell"}], "commentType": "MISCELLANEOUS"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005746"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Belongs to the adenoviridae histone-like nucleoprotein family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Initiator methionine", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "Removed", "evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}]}, {"type": "Chain", "location": {"start": {"value": 2, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Pre-histone-like nucleoprotein", "evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "featureId": "PRO_5041753850"}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "Histone-like nucleoprotein", "evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "featureId": "PRO_5041753851"}, {"type": "Region", "location": {"start": {"value": 91, "modifier": "EXACT"}, "end": {"value": 113, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Site", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "Cleavage; by viral protease", "evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022562"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "id": "KW-1048", "category": "Cellular component", "name": "Host nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "id": "KW-0945", "category": "Biological process", "name": "Host-virus interaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022921"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "id": "KW-0426", "category": "Developmental stage", "name": "Late protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001264104"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022524"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "id": "KW-1163", "category": "Biological process", "name": "Viral penetration into host nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022844"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "id": "KW-0946", "category": "Cellular component", "name": "Virion"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023296"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_04056"}], "id": "KW-1160", "category": "Biological process", "name": "Virus entry into host cell"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-APJIPR3OD0OPL", "citationType": "submission", "authors": ["Dastjerdi A.", "Jeckel S.", "Davies H.", "Irving J.", "Lounge C.", "Plummer C.", "Vidovszky M.Z.", "Harrach B.", "Chantrey J.", "Williams J."], "title": "Novel adenovirus associated with necrotizing bronchiolitis in a captive reindeer (Rangifer tarandus).", "publicationDate": "JUL-2021", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UDF05962.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001264104"}], "value": "UK_2021", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UDF05962.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001264104"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "MZ507556", "properties": [{"key": "ProteinId", "value": "UDF05962.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP001264104", "properties": [{"key": "Component", "value": "Segment"}]}, {"database": "GO", "id": "GO:0043657", "properties": [{"key": "GoTerm", "value": "C:host cell"}, {"key": "GoEvidenceType", "value": "IEA:GOC"}]}, {"database": "GO", "id": "GO:0044196", "properties": [{"key": "GoTerm", "value": "C:host cell nucleolus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0019028", "properties": [{"key": "GoTerm", "value": "C:viral capsid"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0046718", "properties": [{"key": "GoTerm", "value": "P:symbiont entry into host cell"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0075732", "properties": [{"key": "GoTerm", "value": "P:viral penetration into host nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "HAMAP", "id": "MF_04056", "properties": [{"key": "EntryName", "value": "ADV_PVII"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR004912", "properties": [{"key": "EntryName", "value": "Adeno_VII"}]}, {"database": "Pfam", "id": "PF03228", "properties": [{"key": "EntryName", "value": "Adeno_VII"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAILISPSNNTGWGLGCNRMYGGARIRSDMHPVKVRSHYRAAWGSRTGRVGRRGAAAAAAAAAAADAAIATGDPVSDTIEAVVAEARRYRRRRRRGVRGVRRTRRNPRTAQQRRVRRLRRQVARARRIGRRAAAMAAAAGRCPAGAVTSIGSATRPPAPGCLS", "length": 163, "molWeight": 17461, "crc64": "392E00D0E7D99E59", "md5": "EC8898AE8BF5ECE67DFFA041AF8F06B3"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBUNIT": 1, "SUBCELLULAR LOCATION": 2, "INDUCTION": 1, "PTM": 1, "MISCELLANEOUS": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Initiator methionine": 1, "Chain": 2, "Region": 1, "Site": 1}, "uniParcId": "UPI001E6D66F9"}, "cluster_size": 1, "family": "Adenoviridae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXW8", "uniProtkbId": "TXU9D_MEGOP", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Megalopyge opercularis", "commonName": "Southern flannel moth", "synonyms": ["Phalaena opercularis"], "taxonId": 1113279, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Megalopygidae", "Megalopyge"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-megalopygitoxin(9)-Mo13"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37428925"}], "value": "U-MPTX(9)-Mo13"}, {"evidences": [{"evidenceCode": "ECO:0000312", "source": "EMBL", "id": "WJJ70391.1"}], "value": "U-MPTX.9-13"}]}, "flag": "Precursor"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Probable toxin"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Expressed by the venom apparatus"}], "commentType": "TISSUE SPECIFICITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}], "value": "Larvae"}], "commentType": "DEVELOPMENTAL STAGE"}, {"commentType": "MASS SPECTROMETRY", "method": "MALDI", "molWeight": 3018.43, "molWeightError": 0.0, "note": "Monoisotopic mass.", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37428925"}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the caterpillar 9 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000255"}]}, {"type": "Peptide", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 48, "modifier": "EXACT"}}, "description": "U-megalopygitoxin(9)-Mo13", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}], "featureId": "PRO_0000461526"}, {"type": "Disulfide bond", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000305", "source": "PubMed", "id": "37428925"}]}], "keywords": [{"id": "KW-0165", "category": "PTM", "name": "Cleavage on pair of basic residues"}, {"id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"id": "KW-0732", "category": "Domain", "name": "Signal"}, {"id": "KW-0800", "category": "Molecular function", "name": "Toxin"}], "references": [{"referenceNumber": 1, "citation": {"id": "37428925", "citationType": "journal article", "authors": ["Walker A.A.", "Robinson S.D.", "Merritt D.J.", "Cardoso F.C.", "Goudarzi M.H.", "Mercedes R.S.", "Eagles D.A.", "Cooper P.", "Zdenek C.N.", "Fry B.G.", "Hall D.W.", "Vetter I.", "King G.F."], "citationCrossReferences": [{"database": "PubMed", "id": "37428925"}, {"database": "DOI", "id": "10.1073/pnas.2305871120"}], "title": "Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).", "publicationDate": "2023", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "firstPage": "e2305871120", "lastPage": "e2305871120", "volume": "120"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [MRNA]", "MASS SPECTROMETRY", "SYNTHESIS OF 24-48", "SUBCELLULAR LOCATION", "TISSUE SPECIFICITY", "DEVELOPMENTAL STAGE"], "referenceComments": [{"value": "Venom", "type": "TISSUE"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP514873", "properties": [{"key": "ProteinId", "value": "WJJ70391.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0090729", "properties": [{"key": "GoTerm", "value": "F:toxin activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MKLVFLFFIVAVMVSLFVGMTEADKPRFLTTVCQDTYEKCKEQMLKKDKK", "length": 50, "molWeight": 5880, "crc64": "5563084FEF1809AB", "md5": "4CB8BEC3D91F58A66F9B8F20FA354197"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "TISSUE SPECIFICITY": 1, "DEVELOPMENTAL STAGE": 1, "MASS SPECTROMETRY": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Peptide": 1, "Disulfide bond": 1}, "uniParcId": "UPI00388C33A0"}, "cluster_size": 1, "family": "Megalopygidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZED0", "uniProtkbId": "A0AB38ZED0_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71790.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71790.1"}], "value": "Venom cystatin 2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044329978"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71790.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510865", "properties": [{"key": "ProteinId", "value": "WXH71790.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "3.10.450.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR046350", "properties": [{"key": "EntryName", "value": "Cystatin_sf"}]}, {"database": "SUPFAM", "id": "SSF54403", "properties": [{"key": "EntryName", "value": "Cystatin/monellin"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLKITLSLCLFVLMFAAYSDASLSSEKPPLIRPGLNKVGVVKEISVDHPQLKKSLKRVIAEKNTNIKIVKIIKATRQTINGYAYNVQFLAEEGGKQKTCNANYVVLFGKILGTQKQALRIRKFECK", "length": 126, "molWeight": 14112, "crc64": "D2E83907E2C03A2F", "md5": "3203F0F4DE16A8369B130C4A83C76A19"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BD41D"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7NIW7", "uniProtkbId": "A0AAU7NIW7_9FABA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Saraca asoca", "taxonId": 1073321, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96861.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Fabales", "Fabaceae", "Detarioideae", "Saraceae", "Saraca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96861.1"}], "value": "Chalcone isomerase"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96861.1"}], "value": "CHI"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 48, "modifier": "EXACT"}, "end": {"value": 48, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96861.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96861.1"}], "id": "KW-0413", "category": "Molecular function", "name": "Isomerase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-E4U7KMIOLH7AI", "citationType": "submission", "authors": ["Himaja K.", "Veerapandiyan K.", "Usha B."], "title": "Transcriptome analysis of Saraca asoca.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBR96861.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP905503", "properties": [{"key": "ProteinId", "value": "XBR96861.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016853", "properties": [{"key": "GoTerm", "value": "F:isomerase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MVMWWKLSRNGIWVGQGLFLPQPSHLWLTLSLLSWLSEPNFVFSSSWT", "length": 48, "molWeight": 5665, "crc64": "F92164DDB39C10DA", "md5": "B12F5B088862B64E6CDDB9D06BF0C9B3"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D391B1"}, "cluster_size": 1, "family": "Fabaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N6I8", "uniProtkbId": "A0AAN0N6I8_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34107.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34107.1"}], "value": "Dopamine-like receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 81, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 115, "modifier": "EXACT"}, "end": {"value": 135, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 155, "modifier": "EXACT"}, "end": {"value": 176, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 197, "modifier": "EXACT"}, "end": {"value": 219, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 239, "modifier": "EXACT"}, "end": {"value": 262, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 429, "modifier": "EXACT"}, "end": {"value": 447, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 467, "modifier": "EXACT"}, "end": {"value": 490, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 95, "modifier": "EXACT"}, "end": {"value": 487, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34107.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155033", "properties": [{"key": "ProteinId", "value": "WRW34107.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0071880", "properties": [{"key": "GoTerm", "value": "P:adenylate cyclase-activating adrenergic receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043410", "properties": [{"key": "GoTerm", "value": "P:positive regulation of MAPK cascade"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd15067", "properties": [{"key": "EntryName", "value": "7tmA_Dop1R2-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24248", "properties": [{"key": "EntryName", "value": "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24248:SF185", "properties": [{"key": "EntryName", "value": "DOPAMINE RECEPTOR 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SMART", "id": "SM01381", "properties": [{"key": "EntryName", "value": "7TM_GPCR_Srsx"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSNVVEIQNFLPNLNVYSQLSVPSFFNNDTQNKYSNDVVSFLNVTDLNKVTKLTKVFLISNLVLANKTNADPSFNIYHPKLAFFLTLICILVVSGNFLIILAVRKSRQLRQQTTNYFVASLAFADALVGLVVMPFSVVQEVMNKIWIFGPDWCDLWHSFDVLASTSSILSLCVISIDRYWAITDPMTYSIKMSQSKAIYLIALVWIASCLISFPAIFWWRAVSPGNKPYECNFPVSTGYIVFSSTLSFYGPLIVMVVVYYRIYKAAVEQTKSLKKGAKTISYTGTNSNLGHFDNGQINSKKTNKNFNSDHMITLRMHRGGNLETDFETEPKFIKQSSVDVCDTENSSRFKKLNYFLSQINNQSKKKRFFISDSKLETRFNNVAANNEESTEKKRNLEKSQLSLGTIKNQANNSWSISRKVSKLAKERKAAKTLGIVMGVFILCWLPFFTTHIVMGICGQNCDINEDLVYSVVTWLGWLNSGMNPFIYACWSRDFRKAFRKILCGFREKPKNLSKGYSSSYFLSKINTNSLSHLNKKRNTLNDRQLNKKKKSNDNFEYKKEAKTFCTKINEKEEKMRFQIQSHNSKDNKLKIDILDSSIKEKKFSEKVIKKDDIDKKLSLNDKNNTSDDKFLKKDEKIYCLTENDSHNEKTLIFDDLLNSLKSDKNNFNKNLQTDQFNYKITYESTNSSLNQSIKNTTMNEELSEEFIIKIQLLDSS", "length": 716, "molWeight": 82317, "crc64": "372DE219E16C9E9D", "md5": "FB39AEB5F0CA8B5282D24A31872BF280"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI003255B236"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7YDP2", "uniProtkbId": "A0AAU7YDP2_NIDPL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Nidirana pleuraden", "commonName": "Yunnan pond frog", "synonyms": ["Babina pleuraden"], "taxonId": 369511, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87677.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Ranoidea", "Ranidae", "Nidirana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87677.1"}], "value": "Amplexin 3"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043986396"}, {"type": "Non-terminal residue", "location": {"start": {"value": 105, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87677.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "38891597", "citationType": "journal article", "authors": ["Zheng P.", "Gong Y.", "Wang B.", "Yu H.", "Huang S.", "Liao X.", "Jiang J.", "Ran J.", "Xie F."], "citationCrossReferences": [{"database": "PubMed", "id": "38891597"}], "title": "Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.", "publicationDate": "2024", "journal": "Animals (Basel)", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87677.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-E24AGF4876IHP", "citationType": "submission", "authors": ["Zheng P."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87677.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP583593", "properties": [{"key": "ProteinId", "value": "XBY87677.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.10.60.10", "properties": [{"key": "EntryName", "value": "CD59"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR045860", "properties": [{"key": "EntryName", "value": "Snake_toxin-like_sf"}]}, {"database": "SUPFAM", "id": "SSF57302", "properties": [{"key": "EntryName", "value": "Snake toxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKAMITLLILGLLLIHGEVPCLCPANLYYILLGETLKCYTMRSDDTGKHFNYKSIDCKENENRCLKKNMNDGCGYLSMGCGTEQDCQEYPSFIKTVCCEWDNCNK", "length": 105, "molWeight": 11965, "crc64": "9DECBB5C1A87BD49", "md5": "46C5F903EFC168FBF94D2E61BF79FD53"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D309C2"}, "cluster_size": 1, "family": "Ranidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LP71", "uniProtkbId": "A0AAN0LP71_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2024-10-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34082.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34082.1"}], "value": "Ligated ion channel binding I - glutamate"}}]}, "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34082.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155008", "properties": [{"key": "ProteinId", "value": "WRW34082.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MAIWDLKTIICSSTITVRSSTDKKHNFMGILGPVYESNFPRSVFNVTSFDSKDCNVGHRFSNGSFNGMYKEIIDKNLDLGIFSSKHQLLYEEFTYSPVKGYTNKYRKNQLQNFGFTIDSYNYNSNSQFTNYILASLSVLLIELDKSVYLNNLQDLLVSKMYQPFFYTEDIEDYFKFSSKKLNKDIWKLYKKRNTKVYTVCNRANDFKLILRCMITMKRTKIVLIFEKRLLSMFGPAYCSNAHQYIERQDPYVIQYSKQLEEILTFIPFNKKMKREKKIFLDK", "length": 282, "molWeight": 33417, "crc64": "89919240940E0649", "md5": "806864139A0BAA15BD6EDDB5C5174C5C"}, "extraAttributes": {"uniParcId": "UPI003254B18A"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S1R7", "uniProtkbId": "A0AA96S1R7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50106.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50106.1"}], "value": "IgGFc-binding protein-like protein 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 2203, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041675906"}, {"type": "Domain", "location": {"start": {"value": 2066, "modifier": "EXACT"}, "end": {"value": 2199, "modifier": "EXACT"}}, "description": "NTR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50189"}]}, {"type": "Region", "location": {"start": {"value": 1994, "modifier": "EXACT"}, "end": {"value": 2021, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 2003, "modifier": "EXACT"}, "end": {"value": 2012, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022837"}], "id": "KW-0106", "category": "Ligand", "name": "Calcium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50106.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460183", "properties": [{"key": "ProteinId", "value": "WNS50106.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007154", "properties": [{"key": "GoTerm", "value": "P:cell communication"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0030001", "properties": [{"key": "GoTerm", "value": "P:metal ion transport"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "2.60.40.2030", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "10"}]}, {"database": "InterPro", "id": "IPR051171", "properties": [{"key": "EntryName", "value": "CaCA"}]}, {"database": "InterPro", "id": "IPR038081", "properties": [{"key": "EntryName", "value": "CalX-like_sf"}]}, {"database": "InterPro", "id": "IPR003644", "properties": [{"key": "EntryName", "value": "Calx_beta"}]}, {"database": "InterPro", "id": "IPR035234", "properties": [{"key": "EntryName", "value": "IgGFc-bd_N"}]}, {"database": "InterPro", "id": "IPR001134", "properties": [{"key": "EntryName", "value": "Netrin_domain"}]}, {"database": "PANTHER", "id": "PTHR11878:SF65", "properties": [{"key": "EntryName", "value": "NA_CA-EXCHANGE PROTEIN, ISOFORM G"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11878", "properties": [{"key": "EntryName", "value": "SODIUM/CALCIUM EXCHANGER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03160", "properties": [{"key": "EntryName", "value": "Calx-beta"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "Pfam", "id": "PF17517", "properties": [{"key": "EntryName", "value": "IgGFc_binding"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00237", "properties": [{"key": "EntryName", "value": "Calx_beta"}, {"key": "MatchStatus", "value": "10"}]}, {"database": "SUPFAM", "id": "SSF141072", "properties": [{"key": "EntryName", "value": "CalX-like"}, {"key": "MatchStatus", "value": "10"}]}, {"database": "PROSITE", "id": "PS50189", "properties": [{"key": "EntryName", "value": "NTR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSFGESLPMKLFLLDLLLALLAFAAPSEGAGNSGNEFYLACAPNRFDKEGQCTFYITTEETTTVSVVISHKSVSGNSGSTVTTVKGSTTIYQLPTALTLGTAAMYAFRQSDFGVHFKAEEDKKIIIYSVNEDQASTDGYLALPKHQTVSGEYVYFVMSYTRPKTTILGRVRSFIIVVGTEDNTVFTVTIKLASGNIVLGPLCRPAVGFNGQKATCTIGRGGTFAAFSLADLTGTKIESNKPLTMYAGHQCAQVPNDVTACDHLIEQMPPVENLGFRHVLSPSLGRTGDAVRVLAVEDDTVIKIACNNGQGISQPVVSATINSGMFHERILPARTGFCFIESDLPVAVAQYALGHSYDNTVQTDPFMILIPPLGQFRRYYTIVFVDSQMIDTQGVRTRFSPKLTIIIPVAHYQPNQILFDGDPIEGLQGSHSTIPIKDQDGVVRVYAFRWDVPKSVPLGDHTVEHTKPAASIGIIVYGFERENSYGYVGGMELNPLAVTTFCFDGLNFEASEGDGAAALRLQRTGPTKARVCIATECADGSAMAGVHYQSFSQDCCFESGSSLAVCNVPLIDNGVCGEPDRSFTCNLKPQPEQMACNHTSTVTIKDDDKLMIGLTDDMFRVDESAGSVEVCVRMSGCLLDEPLPLSVQTTPSAQDILAQEGSVLATAESDYDSSDLGYIIPAGKSSVVVCKELPIIDDFVVESSECLGIELIAPGDVTVQGSSTGTVCITDDDVEVMLMFKTDEVDVTEGEGLVEVCLMSSEKVPSETTVKILLSDCPGEPCDGAANAGSDYNDGDYMVVFGAGQTRACVMIPIQDDSVLEKKECFKVNYMIPDDAPGVIRSDVGPNEVNINVVDDDVLSVQFSPASYSVHESEGLAMMTLQANTTAQCPFNVEVFTQDRSATAPSDYISYEKNLVQFPAMTTTLRLDVIIIDDEDHECAETFMGCLTVPDQAAESGVVAADEHQCAPVTIATDSSDDITVGFVDPSPVTVTEGLVNVEVSVRLSRPSLYPVKVQVKPLAGSADSGRDFLAVAAEVIFTPGSTRKRVNIPIVDDDVSEPDETFSISLVVLESCPGVSVEGVPLEVVVKDNDSIECGWEPPQYSIKEDGGLVELSVACDGHASRPICLAVSFQDGLATDLFDYASLESQTITINPGSTTGTFPVPILDDSVLEKPEDFSAILSLCSDDDSGLDITVGVETSTTTIIDDDVIQCGFSPTTYHTDEDNDAMLKIKCNGTASYDYVVMVTTEEQSATEPEDYDGGKYNVVILAGETMATLDVPITTDTILEGNETFLAILSTAVSDSIVEDPEASTADVIIIDDVNDIVMCAFSQPEYTVSESSNELCLILECTGEFSVPFNLQVLHHSNLEAMDGSDFVGASQAITFEPGLSSMPVCVRIPDDGNAECNEKFSTELVLPGITSELGVQIGRTSIALVTIRDDDIVTCMFAGLEGDIVIEESKNATIHVMLSGASSRPIQCLLTTEDISATSGMDYQGGSKQAVFLPGESQKTVVFPSIDDREPEAKECYKVTLSTTEQFSACGAVVGERREQIVCLIDNDAVVVNFDPDRYSVEESSGEVELFVKISNSAVKDFMVDITCTSGTASAGSDFVSGPHPVTIPMGSMGAMATVPITMDDVYEGEEKFSCVITADSSTGITPGEKDTASITVDDDDCVQFSVSKYCVDLESGTASGVVTASIEVERTATVLIYAADRTTGLPVRLEEEGGTAEVNFEPGAPRQADFSLNLEEGDLVRYLPLNPINPDCQPRATPDTSGGYVIPLPPTSPTPPPHPPKNFISAGFDLQRYTVQNGQDFVVVNVSLNDTAKEEQLCLRVSTQDQSAVGSVHYQGGAFRVSIAQDRSRGLARIPIFTNRIEQQVQFSLQLEPCPGAHPDTQISIVRGSARAVIPHPLGKPSPCPSVAPSTVTASASSCPVTTTITQPTTTCSVSTRVTTETFTVASSCSTQSCPAPMTTTTTATIVSTREPEQTSCPVATETTTKLVTRTATPPAPECPSTPPTTSCDPSTVTRSVVEKSTETLTQVVTRTASTTCPPSSPCPSPTPCPSTPHPACALKNSCYVRSPNAKEACRSDIVALVKTTVKRFLDTCIYQVKVKKVYKGSALLSTALSNKLISLYFPPRSCSSDCEETYINGCLVLPPDQFYLVGTHLRVDHQGHTLVAELPQNFVLEQPTSKQLKKLTQLSSCTENN", "length": 2203, "molWeight": 235673, "crc64": "3BF0B619D0B3EF21", "md5": "C081C5B8753A735AC9C5D1794C79C43A"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B2BD948"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6R3M9", "uniProtkbId": "A0AAU6R3M9_9METZ", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucetta chagosensis", "taxonId": 185688, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC81644.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Calcarea", "Calcinea", "Clathrinida", "Leucettidae", "Leucetta"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00040165"}], "value": "X-box-binding protein 1"}}, "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC81644.1"}], "value": "XBP1_1"}}], "features": [{"type": "Domain", "location": {"start": {"value": 4, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "BZIP", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50217"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 73, "modifier": "EXACT"}, "end": {"value": 73, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC81644.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38952658", "citationType": "journal article", "authors": ["Posadas N.", "Conaco C."], "citationCrossReferences": [{"database": "PubMed", "id": "38952658"}], "title": "Gene networks governing the response of a calcareous sponge to future ocean conditions reveal lineage-specific XBP1 regulation of the unfolded protein response.", "publicationDate": "2024", "journal": "Ecol. Evol.", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC81644.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-B6JVVS90CVM02", "citationType": "submission", "authors": ["Posadas N.", "Conaco C."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZC81644.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP627507", "properties": [{"key": "ProteinId", "value": "WZC81644.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.20.5.170", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR004827", "properties": [{"key": "EntryName", "value": "bZIP"}]}, {"database": "InterPro", "id": "IPR046347", "properties": [{"key": "EntryName", "value": "bZIP_sf"}]}, {"database": "InterPro", "id": "IPR052470", "properties": [{"key": "EntryName", "value": "ER_Stress-Reg_TF"}]}, {"database": "PANTHER", "id": "PTHR46542", "properties": [{"key": "EntryName", "value": "X-BOX BINDING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46542:SF1", "properties": [{"key": "EntryName", "value": "X-BOX BINDING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00170", "properties": [{"key": "EntryName", "value": "bZIP_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00338", "properties": [{"key": "EntryName", "value": "BRLZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57959", "properties": [{"key": "EntryName", "value": "Leucine zipper domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50217", "properties": [{"key": "EntryName", "value": "BZIP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSFQEKRERRKLNNRVSAQHARDRKKSYLEDLERLVASLKAENTALKSTNASLSSSIQEVRRANESLRSQLCL", "length": 73, "molWeight": 8448, "crc64": "D90C6D6CC216716D", "md5": "9E107510AD8142A5B98EE84A4792D2E9"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D2BEE4"}, "cluster_size": 1, "family": "Leucettidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96C4R8", "uniProtkbId": "A0AA96C4R8_9MONI", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Pteris ensiformis", "taxonId": 265700, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH14459.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Polypodiopsida", "Polypodiidae", "Polypodiales", "Pteridineae", "Pteridaceae", "Pteridoideae", "Pteris", "Pteris subgen. Campteria", "Pteris sect. Excelsae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "value": "Phosphate transporter"}}}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "value": "Sodium-phosphate symporter"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "value": "Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 44, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}]}, {"type": "Transmembrane", "location": {"start": {"value": 101, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}]}, {"type": "Transmembrane", "location": {"start": {"value": 130, "modifier": "EXACT"}, "end": {"value": 150, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}]}, {"type": "Transmembrane", "location": {"start": {"value": 170, "modifier": "EXACT"}, "end": {"value": 195, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}]}, {"type": "Transmembrane", "location": {"start": {"value": 207, "modifier": "EXACT"}, "end": {"value": 229, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}]}, {"type": "Transmembrane", "location": {"start": {"value": 241, "modifier": "EXACT"}, "end": {"value": 265, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022592"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "id": "KW-0592", "category": "Biological process", "name": "Phosphate transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363058"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AGKCUCU9BIRJQ", "citationType": "submission", "authors": ["Dan S."], "publicationDate": "JUL-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNH14459.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR348668", "properties": [{"key": "ProteinId", "value": "WNH14459.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005315", "properties": [{"key": "GoTerm", "value": "F:phosphate transmembrane transporter activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0035435", "properties": [{"key": "GoTerm", "value": "P:phosphate ion transmembrane transport"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "InterPro", "id": "IPR001204", "properties": [{"key": "EntryName", "value": "Phos_transporter"}]}, {"database": "PANTHER", "id": "PTHR11101", "properties": [{"key": "EntryName", "value": "PHOSPHATE TRANSPORTER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11101:SF89", "properties": [{"key": "EntryName", "value": "PHOSPHATE TRANSPORTER"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01384", "properties": [{"key": "EntryName", "value": "PHO4"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MENNIFASMPTVALEIERPWSATYRWIPIAGGLVSFALAFMAGANDIPISFGASVGSGVLTLRQSVLLAFVMEVLGATCLGNRSIDVVDSFILKEMPSNDLLMWGCFMAMFAAASWLALATYLEMPVTSFLSIQGAIIGVCLTVEGWNSIYWSKHDSDSVPHVRGLTGILLSWVMVPSMSLVGAFSFFMVIKVTLLRSLVMGKRTQWLWPLLYGITVTVLVLFVIYMGAPGTSLRFTSLRKVAVISGLSAIVTILLSSIILICLARKRSELLDDSRDTQPDRAIPGQEGNTVEEQKEVSPEDLFKQFNELRVLHTVYEVDEEGVDDSPRSTIRCSPVCGPAIQLKHMLSGTPNQLTFQKLMKAKRITIKQRIVDFVHKIRGYTFDHKIEYGQETAALHAVAKKYHKRVEEPFGFLLTLTASISAYV", "length": 426, "molWeight": 47169, "crc64": "9B923A90BCEEC2BB", "md5": "CDBC64904AE9FD585584C3B14DF25A67"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6}, "uniParcId": "UPI002B307473"}, "cluster_size": 1, "family": "Pteridaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1E9", "uniProtkbId": "A0AAU7P1E9_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30764.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30764.1"}], "value": "Endothelial nitric oxide synthase"}}], "flag": "Fragment"}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 49, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 47, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30764.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 110, "modifier": "EXACT"}, "end": {"value": 110, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30764.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3THMMO2GJQNJE", "citationType": "submission", "authors": ["Amjad A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30760.1"}], "value": "#1 rs1799983", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30764.1"}], "value": "#5 rs1799983", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30764.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892416", "properties": [{"key": "ProteinId", "value": "XBS30760.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "EMBL", "id": "PP892420", "properties": [{"key": "ProteinId", "value": "XBS30764.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MVPEEGMRLSPRTPSGPLPTALHSARLDPRKRSLRRAAPAAAGPRCPQNSSFCPPSWSLGAPGAPHVSTKGITGWDGGGHPCLSRRACKGVLSHTPTPPGWSGLQPWACT", "length": 110, "molWeight": 11495, "crc64": "EBDDDFD9F5065365", "md5": "D2558C54BB013AD0B4D87DF65FA70F3E"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D380E2"}, "cluster_size": 4, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1H1", "uniProtkbId": "A0AAU7P1H1_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30755.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30755.1"}], "value": "Endothelial nitric oxide synthase"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30755.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 47, "modifier": "EXACT"}, "end": {"value": 47, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30755.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3THMMO2GJQNJE", "citationType": "submission", "authors": ["Amjad A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30755.1"}], "value": "#2 rs2070744", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30757.1"}], "value": "#4 rs2070744", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30755.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892411", "properties": [{"key": "ProteinId", "value": "XBS30755.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "EMBL", "id": "PP892413", "properties": [{"key": "ProteinId", "value": "XBS30757.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "LECLESAGVPHLHSGNCSFPSPPCSHQGIKLFPGWLTLPQPCLSATC", "length": 47, "molWeight": 4962, "crc64": "69236847E4BF204E", "md5": "25E91AAD41A8065CC4E5826510909344"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D33350"}, "cluster_size": 3, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QK46", "uniProtkbId": "A0AAU0QK46_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56562.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56562.1"}], "value": "Odorant binding protein/PBP-general odorant binding protein"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56562.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 114, "modifier": "EXACT"}, "end": {"value": 114, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56562.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56562.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56562.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970301", "properties": [{"key": "ProteinId", "value": "WPO56562.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "RKLVKLFLCLKNINKIIFIMFVVRCSSFVVALFCLVSVYAQSDEEAGIKEALRPFVEECADEFGITEEQFEEAKKKGNAGDIDPCFMSCFLKKAGFFDSQGKFDVDSTMAFAKD", "length": 114, "molWeight": 12848, "crc64": "5ECE0901399D3E11", "md5": "D69F1D50B24E315EF13E1B0A99B67BB7"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 2}, "uniParcId": "UPI00308E7599"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MKI4", "uniProtkbId": "A0AA96MKI4_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50107.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011984"}], "value": "small monomeric GTPase"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00011984"}], "value": "3.6.5.2"}]}}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "GTP + H2O = GDP + phosphate + H(+)", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:19669"}, {"database": "ChEBI", "id": "CHEBI:15377"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:37565"}, {"database": "ChEBI", "id": "CHEBI:43474"}, {"database": "ChEBI", "id": "CHEBI:58189"}], "ecNumber": "3.6.5.2", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00048098"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008344"}], "value": "Belongs to the small GTPase superfamily. Ras family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50107.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460184", "properties": [{"key": "ProteinId", "value": "WNS50107.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003924", "properties": [{"key": "GoTerm", "value": "F:GTPase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR051065", "properties": [{"key": "EntryName", "value": "Ras-related_GTPase"}]}, {"database": "InterPro", "id": "IPR005225", "properties": [{"key": "EntryName", "value": "Small_GTP-bd"}]}, {"database": "InterPro", "id": "IPR001806", "properties": [{"key": "EntryName", "value": "Small_GTPase"}]}, {"database": "NCBIfam", "id": "TIGR00231", "properties": [{"key": "EntryName", "value": "small_GTP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR45704", "properties": [{"key": "EntryName", "value": "RAS-LIKE FAMILY MEMBER 11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00071", "properties": [{"key": "EntryName", "value": "Ras"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00449", "properties": [{"key": "EntryName", "value": "RASTRNSFRMNG"}]}, {"database": "SMART", "id": "SM00175", "properties": [{"key": "EntryName", "value": "RAB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00173", "properties": [{"key": "EntryName", "value": "RAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00174", "properties": [{"key": "EntryName", "value": "RHO"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51419", "properties": [{"key": "EntryName", "value": "RAB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51421", "properties": [{"key": "EntryName", "value": "RAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51420", "properties": [{"key": "EntryName", "value": "RHO"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MMRNTKKEQKLVHWIKVVVLGSGAVGKSALTVRYLTDRFIHDYDPTFEDIYEDEKKPIVVDDEQYALRIVDTAGQIEDIENSFQMRHIASADVVMYVFSLTESQTLHDLISLKDRIDGMSATPKPSVMVGNKSDLTHMRCVSQEEAMGVANNLNCSYFEMSVASSSRESVDTVFQSAVKLAVDSQKVLENQKDGKSVGKSVKSALKWLKKVHRRKSVCSPMFFYVSPVADESSHQSPPATFV", "length": 242, "molWeight": 27134, "crc64": "92531BE47DBC4066", "md5": "D7F47AD30BF8864EF0439A78B33EA432"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1, "SIMILARITY": 1}, "uniParcId": "UPI002B321115"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7BBW5", "uniProtkbId": "A0AAU7BBW5_9NEOB", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Breviceps mossambicus", "commonName": "Mozambique rain frog", "taxonId": 143669, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44909.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Microhyloidea", "Brevicipitidae", "Breviceps"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "value": "Galectin"}}}, "features": [{"type": "Domain", "location": {"start": {"value": 5, "modifier": "EXACT"}, "end": {"value": 135, "modifier": "EXACT"}}, "description": "Galectin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51304"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022734"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "id": "KW-0430", "category": "Ligand", "name": "Lectin"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-83KR4A84OEATV", "citationType": "submission", "authors": ["Zaman S.", "Roelants K."], "title": "Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBE44909.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR543004", "properties": [{"key": "ProteinId", "value": "XBE44909.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030395", "properties": [{"key": "GoTerm", "value": "F:lactose binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043236", "properties": [{"key": "GoTerm", "value": "F:laminin binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00070", "properties": [{"key": "EntryName", "value": "GLECT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.200", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR013320", "properties": [{"key": "EntryName", "value": "ConA-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR044156", "properties": [{"key": "EntryName", "value": "Galectin-like"}]}, {"database": "InterPro", "id": "IPR001079", "properties": [{"key": "EntryName", "value": "Galectin_CRD"}]}, {"database": "PANTHER", "id": "PTHR11346", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11346:SF97", "properties": [{"key": "EntryName", "value": "GALECTIN-1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00337", "properties": [{"key": "EntryName", "value": "Gal-bind_lectin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00908", "properties": [{"key": "EntryName", "value": "Gal-bind_lectin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00276", "properties": [{"key": "EntryName", "value": "GLECT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49899", "properties": [{"key": "EntryName", "value": "Concanavalin A-like lectins/glucanases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51304", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGGERVVFNNLEIKPGKRVEVKGYIPEDCKDFSVNLGKDENNLILHANARFDFRNDKRVLACNSLKDCEWGEEVIMDIFPFQLGTEISLSLTFDTEKVNMIFSTGEEISFPVRFELDMINYVALRGLIFRCLTSE", "length": 135, "molWeight": 15507, "crc64": "D5CB08EACC2C34FA", "md5": "268E935B88337E3EDB83F1E43E87AD71"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D3C307"}, "cluster_size": 1, "family": "Brevicipitidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8L104", "uniProtkbId": "A0AAU8L104_HALDU", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28599.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28599.1"}], "value": "SFRPc"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 521, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043806746"}, {"type": "Domain", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "FZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50038"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 43, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 113, "modifier": "EXACT"}, "end": {"value": 137, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022837"}], "id": "KW-0106", "category": "Ligand", "name": "Calcium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-EGAS7BV8JDS8L", "citationType": "submission", "authors": ["Mikhailov K.", "Kravchuk O.", "Lyupina Y.", "Adameyko K."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCN28599.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP971933", "properties": [{"key": "ProteinId", "value": "XCN28599.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042813", "properties": [{"key": "GoTerm", "value": "F:Wnt receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0017147", "properties": [{"key": "GoTerm", "value": "F:Wnt-protein binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0060070", "properties": [{"key": "GoTerm", "value": "P:canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0035567", "properties": [{"key": "GoTerm", "value": "P:non-canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd07066", "properties": [{"key": "EntryName", "value": "CRD_FZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.2030", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "1.10.2000.10", "properties": [{"key": "EntryName", "value": "Frizzled cysteine-rich domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR038081", "properties": [{"key": "EntryName", "value": "CalX-like_sf"}]}, {"database": "InterPro", "id": "IPR003644", "properties": [{"key": "EntryName", "value": "Calx_beta"}]}, {"database": "InterPro", "id": "IPR015526", "properties": [{"key": "EntryName", "value": "Frizzled/SFRP"}]}, {"database": "InterPro", "id": "IPR020067", "properties": [{"key": "EntryName", "value": "Frizzled_dom"}]}, {"database": "InterPro", "id": "IPR036790", "properties": [{"key": "EntryName", "value": "Frizzled_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR11309", "properties": [{"key": "EntryName", "value": "FRIZZLED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03160", "properties": [{"key": "EntryName", "value": "Calx-beta"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01392", "properties": [{"key": "EntryName", "value": "Fz"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00237", "properties": [{"key": "EntryName", "value": "Calx_beta"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00063", "properties": [{"key": "EntryName", "value": "FRI"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF141072", "properties": [{"key": "EntryName", "value": "CalX-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF63501", "properties": [{"key": "EntryName", "value": "Frizzled cysteine-rich domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50038", "properties": [{"key": "EntryName", "value": "FZ"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAAAYSSKRTLLFAIIVFFTSVCQGSLTYGIQCVANTDQNDFCYHFPFQHSAIPNLGGGFDSGDIEQELRSFSQLYSLGCSNALVQLLCSYYKPPCFPMEDFTIRLPPCQELCVYVRSTCEPTLKSYGRSWPDILDCSRFPSSCNTTLCFPPYVSLDQHQAIPVLPVPRLGQPPNVKKGSVIRMRGGQSVGFSRDQYMVEEGAAVNVTLAVDCPPDCDFNVTLEHSLSDTAAGAGMSDFTAAPYNAVFPAGVNSAVVTVRAIDDNIAEKNETFSLKIVSVNSTCGVKIGTRSSATIIIKDNDTVQVCLNETAISVKEGKQTKLTLVADKPFSCNFTVIVATQNGTAAAGEDFIGGPYSVVFTPGQLTEMVCINTTEDNMFELPENFSAAIKAPLQNDVSVTAGDCNTSVAIVTIYDMITTCSKPFCKRRSGDTICQVPTSTAGAVSGCTGPFDLTTCKACYYSKKPRSHPQECRLQCMGEVDEDCIRSYGRCVRRRNYKRFGKVSSTLKKAANFKCFRPIC", "length": 521, "molWeight": 56647, "crc64": "E23AEDBF1D829E5F", "md5": "35DFA0339137B66C36339047C38D3E12"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Disulfide bond": 2}, "uniParcId": "UPI0035D3C0A1"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXB8", "uniProtkbId": "CGLR_AETTU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-09", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 4.0, "organism": {"scientificName": "Aethina tumida", "commonName": "Small hive beetle", "taxonId": 116153, "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Coleoptera", "Polyphaga", "Cucujiformia", "Nitidulidae", "Nitidulinae", "Aethina"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"value": "Cyclic GMP-AMP synthase-like receptor"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37379839"}], "value": "At-cGLR"}], "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}], "value": "2.7.7.86"}]}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "37379839"}], "value": "cGLR"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}], "value": "Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:37379839). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:37379839). Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor (PubMed:37379839)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "GTP + ATP = 2',3'-cGAMP + 2 diphosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:42064"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:33019"}, {"database": "ChEBI", "id": "CHEBI:37565"}, {"database": "ChEBI", "id": "CHEBI:143093"}], "ecNumber": "2.7.7.86", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:42065"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}]}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "GTP + ATP = pppGp(2'-5')A + diphosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:23748"}, {"database": "ChEBI", "id": "CHEBI:30616"}, {"database": "ChEBI", "id": "CHEBI:33019"}, {"database": "ChEBI", "id": "CHEBI:37565"}, {"database": "ChEBI", "id": "CHEBI:78318"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:23749"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}]}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "pppGp(2'-5')A = 2',3'-cGAMP + diphosphate", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:23924"}, {"database": "ChEBI", "id": "CHEBI:33019"}, {"database": "ChEBI", "id": "CHEBI:78318"}, {"database": "ChEBI", "id": "CHEBI:143093"}], "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}, "physiologicalReactions": [{"directionType": "left-to-right", "reactionCrossReference": {"database": "Rhea", "id": "RHEA:23925"}, "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "37379839"}]}]}, {"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}, {"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the mab-21 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 396, "modifier": "EXACT"}}, "description": "Cyclic GMP-AMP synthase-like receptor", "featureId": "PRO_0000460012"}, {"type": "Region", "location": {"start": {"value": 376, "modifier": "EXACT"}, "end": {"value": 396, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 380, "modifier": "EXACT"}, "end": {"value": 396, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 63, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 75, "modifier": "EXACT"}, "end": {"value": 77, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 75, "modifier": "EXACT"}, "end": {"value": 75, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 77, "modifier": "EXACT"}, "end": {"value": 77, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 194, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:37565"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "GTP", "id": "ChEBI:CHEBI:37565"}}, {"type": "Binding site", "location": {"start": {"value": 194, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:18420"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "Mg(2+)", "id": "ChEBI:CHEBI:18420", "note": "catalytic"}}, {"type": "Binding site", "location": {"start": {"value": 241, "modifier": "EXACT"}, "end": {"value": 244, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 262, "modifier": "EXACT"}, "end": {"value": 262, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 275, "modifier": "EXACT"}, "end": {"value": 279, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "Q8N884"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}, {"type": "Binding site", "location": {"start": {"value": 286, "modifier": "EXACT"}, "end": {"value": 286, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29035"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "ligand": {"name": "Mn(2+)", "id": "ChEBI:CHEBI:29035"}}, {"type": "Binding site", "location": {"start": {"value": 287, "modifier": "EXACT"}, "end": {"value": 287, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29035"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "ligand": {"name": "Mn(2+)", "id": "ChEBI:CHEBI:29035"}}, {"type": "Binding site", "location": {"start": {"value": 292, "modifier": "EXACT"}, "end": {"value": 292, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29035"}], "evidences": [{"evidenceCode": "ECO:0000250", "source": "UniProtKB", "id": "D6WI29"}], "ligand": {"name": "Mn(2+)", "id": "ChEBI:CHEBI:29035"}}], "keywords": [{"id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"id": "KW-0342", "category": "Ligand", "name": "GTP-binding"}, {"id": "KW-0391", "category": "Biological process", "name": "Immunity"}, {"id": "KW-0399", "category": "Biological process", "name": "Innate immunity"}, {"id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"id": "KW-0464", "category": "Ligand", "name": "Manganese"}, {"id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"id": "KW-0548", "category": "Molecular function", "name": "Nucleotidyltransferase"}, {"id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-E6ML8M9BS2HAC", "citationType": "submission", "authors": ["Evans J.", "Huang Q.", "Sim S.B.", "Corpuz R.L.", "Simmonds T.J.", "Childers A.", "Kuhn K.", "Smith T.", "Geib S.M."], "title": "Chromosome-scale assembly of Aethina tumida.", "publicationDate": "APR-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}, {"referenceNumber": 2, "citation": {"id": "37379839", "citationType": "journal article", "authors": ["Li Y.", "Slavik K.M.", "Toyoda H.C.", "Morehouse B.R.", "de Oliveira Mann C.C.", "Elek A.", "Levy S.", "Wang Z.", "Mears K.S.", "Liu J.", "Kashin D.", "Guo X.", "Mass T.", "Sebe-Pedros A.", "Schwede F.", "Kranzusch P.J."], "citationCrossReferences": [{"database": "PubMed", "id": "37379839"}, {"database": "DOI", "id": "10.1016/j.cell.2023.05.038"}], "title": "cGLRs are a diverse family of pattern recognition receptors in innate immunity.", "publicationDate": "2023", "journal": "Cell", "firstPage": "3261", "lastPage": "3276", "volume": "186"}, "referencePositions": ["FUNCTION", "CATALYTIC ACTIVITY"]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "JALKMD010000002", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "P0DXB8", "properties": [{"key": "Description", "value": "-"}]}, {"database": "KEGG", "id": "atd:109605901", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0061501", "properties": [{"key": "GoTerm", "value": "F:2',3'-cyclic GMP-AMP synthase activity"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "37379839"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003690", "properties": [{"key": "GoTerm", "value": "F:double-stranded DNA binding"}, {"key": "GoEvidenceType", "value": "IDA:UniProtKB"}], "evidences": [{"evidenceCode": "ECO:0000314", "source": "PubMed", "id": "37379839"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0045087", "properties": [{"key": "GoTerm", "value": "P:innate immune response"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.10.1410.40", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.460.90", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR046903", "properties": [{"key": "EntryName", "value": "Mab-21-like_nuc_Trfase"}]}, {"database": "InterPro", "id": "IPR046906", "properties": [{"key": "EntryName", "value": "Mab-21_HhH/H2TH-like"}]}, {"database": "InterPro", "id": "IPR024810", "properties": [{"key": "EntryName", "value": "MAB21L/cGLR"}]}, {"database": "PANTHER", "id": "PTHR10656", "properties": [{"key": "EntryName", "value": "CELL FATE DETERMINING PROTEIN MAB21-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10656:SF42", "properties": [{"key": "EntryName", "value": "CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03281", "properties": [{"key": "EntryName", "value": "Mab-21"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF20266", "properties": [{"key": "EntryName", "value": "Mab-21_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM01265", "properties": [{"key": "EntryName", "value": "Mab-21"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNKYNYMENVLQHINANVISLRDDEIKGNNIILKEILNIIIDKLKTKNIMFRKMYTCIFFGGSYYDGLRVGHPNEFDLDLLLTLHNLTKPIITKANEPGYVFLKLGNINNFLNIDDFKMYKQLSNLINKNGYLDVRKVLSWFEGIVTSSLNDIKEGSIYNFQIKGNTYKGTIHKGGPAFTLKIKGPNGSNMDIDLVPCFRFTEEHWPQGFKKSTSQQKSFFIVPKPLPDSTKSHYWRLSFQEQERELINNKGRLKPALRLLKQMRDTLNHHRIASYYLKTVFLWQVEEIGVDQSHWNSSLSYVFVCALKRYKEFLDSDNLPYFWEKKNNLLSGLHEDTLKNIRGSILKVLTDIESNNKDPNAIVKYLLTPEEQKRIMNGGNPQQSANAENGSCLSM", "length": 396, "molWeight": 45880, "crc64": "379877B0A9CAFCB1", "md5": "631E163A19CE1122FEC308DAD04CFE1F"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 3, "COFACTOR": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1, "Region": 1, "Compositional bias": 1, "Binding site": 12}, "uniParcId": "UPI00096ADF2E"}, "cluster_size": 1, "family": "Nitidulidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QK24", "uniProtkbId": "A0AAU0QK24_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56557.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56557.1"}], "value": "Odorant binding protein/PBP-general odorant binding protein"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008098"}], "value": "Belongs to the PBP/GOBP family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56557.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 89, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56557.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56557.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56557.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970296", "properties": [{"key": "ProteinId", "value": "WPO56557.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "SMR", "id": "A0AAU0QK24", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006072", "properties": [{"key": "EntryName", "value": "Odorant/phero-bd_Lep"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00484", "properties": [{"key": "EntryName", "value": "PBPGOBP"}]}, {"database": "SMART", "id": "SM00708", "properties": [{"key": "EntryName", "value": "PhBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "HQISDRNAGCAILCLSSKMDLLDPEGKLHRGKTVEFAKEHGSDDATAQKMVDILHECDAASAPREDQCMRALEIAMCFKTEIHKLNWAP", "length": 89, "molWeight": 9893, "crc64": "9E77CAB584BE97E7", "md5": "4428C12348302382B2F85B0D30D6226B"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI00308C40B7"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLL0", "uniProtkbId": "A0AAU0QLL0_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56448.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Odorant receptor"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "value": "Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 61, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 73, "modifier": "EXACT"}, "end": {"value": 98, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 136, "modifier": "EXACT"}, "end": {"value": 154, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 174, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 284, "modifier": "EXACT"}, "end": {"value": 303, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 309, "modifier": "EXACT"}, "end": {"value": 328, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}, {"type": "Transmembrane", "location": {"start": {"value": 376, "modifier": "EXACT"}, "end": {"value": 396, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU351113"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56448.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56448.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970341", "properties": [{"key": "ProteinId", "value": "WPO56448.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEMDNFENVSPFDAFKLVIKVLIWTGIYEVNTQRKTIRTAHYVYRILVIFIAVLSLTQHGIRMYQMRDVREELFLALIKGIPVFTLIIKEINIFRYILRINKLHEQIKDSKCMPSNEKDADYLLKNNKFMYTLTKISMLMMFVGFSSFVVFMFIRRYLDPKVQLPSYMPFSTDSMVGFCVAIILDLIIGTWTGFGQYASDLVIATYYAHATVQLKILKYNLISVFGVDKVESNMTIIGNHFQYKDVLDPNLKQRFGYYAEKYRMLICFVQDVDAIFNWHMSIQFFTASANLCFVSSIFSTVKILSSDFVFSTIVALLSASQVFLYCYFGHQVRYESESMNTAIYSSDWMSVSPSLRRDVFTAMTAWHRPISSQVSYIVPVSLVTFVSIMRFAYSLYTLMKAV", "length": 402, "molWeight": 46721, "crc64": "22169AC79122DC8C", "md5": "BEDAB65562672CDA0EAF2FE073CAC7A6"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7}, "uniParcId": "UPI00309197BA"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB reviewed (Swiss-Prot)", "primaryAccession": "P0DXE6", "uniProtkbId": "CGDB_MICSX", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 4.0, "organism": {"scientificName": "Microbacterium sp", "taxonId": 51671, "lineage": ["Bacteria", "Bacillati", "Actinomycetota", "Actinomycetes", "Micrococcales", "Microbacteriaceae", "Microbacterium"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "3'-dehydrocarminate deglycosidase beta subunit"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}], "value": "4.1.99.28"}]}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "34728636"}], "value": "C-deglycosylation enzyme beta subunit"}}, {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "34728636"}], "value": "C-glycoside deglycosidase beta subunit"}, "shortNames": [{"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "34728636"}], "value": "CGD beta subunit"}]}, {"fullName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "34728636"}], "value": "MiCGD beta"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000303", "source": "PubMed", "id": "34728636"}], "value": "carC"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}], "value": "Carbon-carbon bond-cleaving enzyme which participates in a carminate degradation pathway (PubMed:34728636). Cleaves the C-C bond in 3'-dehydrocarminate to form kermesate (PubMed:34728636). Also shows weak activity with other C-glycosides, such as 3''-dehydropuerarin (3''-oxo-puerarin), 3''-dehydroisoorientin (3''-oxo-homoorientin) and 3'-dehydromangiferin (3'-oxo-mangiferin) (PubMed:34728636)"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "3'-dehydrocarminate + H(+) = kermesate + 1,5-anhydro-D-erythro-hex-1-en-3-ulose", "reactionCrossReferences": [{"database": "Rhea", "id": "RHEA:76567"}, {"database": "ChEBI", "id": "CHEBI:15378"}, {"database": "ChEBI", "id": "CHEBI:149530"}, {"database": "ChEBI", "id": "CHEBI:192513"}, {"database": "ChEBI", "id": "CHEBI:195275"}], "ecNumber": "4.1.99.28", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}]}}, {"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}], "value": "Activity is strongly reduced in the presence of chelating agents"}], "commentType": "ACTIVITY REGULATION"}, {"commentType": "BIOPHYSICOCHEMICAL PROPERTIES", "kineticParameters": {"michaelisConstants": [{"constant": 0.39, "unit": "mM", "substrate": "3'-dehydrocarminate", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}]}, {"constant": 7.5, "unit": "mM", "substrate": "3''-dehydropuerarin", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}]}, {"constant": 11.0, "unit": "mM", "substrate": "3''-dehydroisoorientin", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}]}, {"constant": 5.4, "unit": "mM", "substrate": "3'-dehydromangiferin", "evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}]}], "note": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}], "value": "kcat is 23 min(-1) with 3'-dehydrocarminate as substrate. kcat is 0.12 min(-1) with 3''-dehydropuerarin as substrate. kcat is 0.024 min(-1) with 3''-dehydroisoorientin as substrate. kcat is 0.16 min(-1) with 3'-dehydromangiferin as substrate."}]}}, "phDependence": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}], "value": "Optimum pH is 7.5."}]}, "temperatureDependence": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}], "value": "Optimum temperature is around 40 degrees Celsius."}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000269", "source": "PubMed", "id": "34728636"}], "value": "Heterodimer composed of an alpha subunit (CarB) and a beta subunit (CarC)"}], "commentType": "SUBUNIT"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000305"}], "value": "Belongs to the C-glycoside deglycosidase beta subunit family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Chain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 132, "modifier": "EXACT"}}, "description": "3'-dehydrocarminate deglycosidase beta subunit", "featureId": "PRO_0000461031"}], "keywords": [{"id": "KW-0119", "category": "Biological process", "name": "Carbohydrate metabolism"}, {"id": "KW-0456", "category": "Molecular function", "name": "Lyase"}, {"id": "KW-0460", "category": "Ligand", "name": "Magnesium"}], "references": [{"referenceNumber": 1, "citation": {"id": "34728636", "citationType": "journal article", "authors": ["Mori T.", "Kumano T.", "He H.", "Watanabe S.", "Senda M.", "Moriya T.", "Adachi N.", "Hori S.", "Terashita Y.", "Kawasaki M.", "Hashimoto Y.", "Awakawa T.", "Senda T.", "Abe I.", "Kobayashi M."], "citationCrossReferences": [{"database": "PubMed", "id": "34728636"}, {"database": "DOI", "id": "10.1038/s41467-021-26585-1"}], "title": "C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes.", "publicationDate": "2021", "journal": "Nat. Commun.", "firstPage": "6294", "lastPage": "6294", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [GENOMIC DNA]", "FUNCTION", "CATALYTIC ACTIVITY", "COFACTOR", "ACTIVITY REGULATION", "BIOPHYSICOCHEMICAL PROPERTIES", "SUBUNIT"], "referenceComments": [{"value": "5-2b", "type": "STRAIN"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC387600", "properties": [{"key": "ProteinId", "value": "BBE36492.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "P0DXE6", "properties": [{"key": "Description", "value": "-"}]}, {"database": "KEGG", "id": "ag:BBE36492", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0016829", "properties": [{"key": "GoTerm", "value": "F:lyase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR045959", "properties": [{"key": "EntryName", "value": "CGDB"}]}, {"database": "Pfam", "id": "PF19906", "properties": [{"key": "EntryName", "value": "CGDB"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFRERIIVQDSLVADESGSAFRIRLPWYRALPLSTIEELSVTVDGTAFDPARLRIAVNDGEWALAEAQLRTDDVWFVLDDATVRLPGLVLDAGAHEVQATLSMRIPYLPVAGKPLSMAETDQKRMDVKELTA", "length": 132, "molWeight": 14683, "crc64": "CC5C42B95A52C776", "md5": "210A403C715EE5A73B15F37D559CFDC7"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 1, "COFACTOR": 1, "ACTIVITY REGULATION": 1, "BIOPHYSICOCHEMICAL PROPERTIES": 1, "SUBUNIT": 1, "SIMILARITY": 1}, "countByFeatureType": {"Chain": 1}, "uniParcId": "UPI003390784B"}, "cluster_size": 1, "family": "Microbacteriaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHR8", "uniProtkbId": "A0AAQ5BHR8_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519498.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519498.1"}], "value": "Secretory carrier membrane protein 3"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519498.1"}], "value": "SCAMP3"}}], "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 90, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 92, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 49, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHR8"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHR8"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519498.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519498.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16710414", "citationType": "journal article", "authors": ["Gregory S.G.", "Barlow K.F.", "McLay K.E.", "Kaul R.", "Swarbreck D.", "Dunham A.", "Scott C.E.", "Howe K.L.", "Woodfine K.", "Spencer C.C.", "Jones M.C.", "Gillson C.", "Searle S.", "Zhou Y.", "Kokocinski F.", "McDonald L.", "Evans R.", "Phillips K.", "Atkinson A.", "Cooper R.", "Jones C.", "Hall R.E.", "Andrews T.D.", "Lloyd C.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Anderson F.", "Andrew R.W.", "Ashwell R.I.", "Aubin K.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Beasley H.", "Bethel G.", "Bird C.P.", "Bray-Allen S.", "Brown J.Y.", "Brown A.J.", "Buckley D.", "Burton J.", "Bye J.", "Carder C.", "Chapman J.C.", "Clark S.Y.", "Clarke G.", "Clee C.", "Cobley V.", "Collier R.E.", "Corby N.", "Coville G.J.", "Davies J.", "Deadman R.", "Dunn M.", "Earthrowl M.", "Ellington A.G.", "Errington H.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Gay L.", "Ghori M.R.", "Gibson R.", "Gilby L.M.", "Gillett W.", "Glithero R.J.", "Grafham D.V.", "Griffiths C.", "Griffiths-Jones S.", "Grocock R.", "Hammond S.", "Harrison E.S.", "Hart E.", "Haugen E.", "Heath P.D.", "Holmes S.", "Holt K.", "Howden P.J.", "Hunt A.R.", "Hunt S.E.", "Hunter G.", "Isherwood J.", "James R.", "Johnson C.", "Johnson D.", "Joy A.", "Kay M.", "Kershaw J.K.", "Kibukawa M.", "Kimberley A.M.", "King A.", "Knights A.J.", "Lad H.", "Laird G.", "Lawlor S.", "Leongamornlert D.A.", "Lloyd D.M.", "Loveland J.", "Lovell J.", "Lush M.J.", "Lyne R.", "Martin S.", "Mashreghi-Mohammadi M.", "Matthews L.", "Matthews N.S.", "McLaren S.", "Milne S.", "Mistry S.", "Moore M.J.", "Nickerson T.", "O'Dell C.N.", "Oliver K.", "Palmeiri A.", "Palmer S.A.", "Parker A.", "Patel D.", "Pearce A.V.", "Peck A.I.", "Pelan S.", "Phelps K.", "Phillimore B.J.", "Plumb R.", "Rajan J.", "Raymond C.", "Rouse G.", "Saenphimmachak C.", "Sehra H.K.", "Sheridan E.", "Shownkeen R.", "Sims S.", "Skuce C.D.", "Smith M.", "Steward C.", "Subramanian S.", "Sycamore N.", "Tracey A.", "Tromans A.", "Van Helmond Z.", "Wall M.", "Wallis J.M.", "White S.", "Whitehead S.L.", "Wilkinson J.E.", "Willey D.L.", "Williams H.", "Wilming L.", "Wray P.W.", "Wu Z.", "Coulson A.", "Vaudin M.", "Sulston J.E.", "Durbin R.", "Hubbard T.", "Wooster R.", "Dunham I.", "Carter N.P.", "McVean G.", "Ross M.T.", "Harrow J.", "Olson M.V.", "Beck S.", "Rogers J.", "Bentley D.R.", "Banerjee R.", "Bryant S.P.", "Burford D.C.", "Burrill W.D.", "Clegg S.M.", "Dhami P.", "Dovey O.", "Faulkner L.M.", "Gribble S.M.", "Langford C.F.", "Pandian R.D.", "Porter K.M.", "Prigmore E."], "citationCrossReferences": [{"database": "PubMed", "id": "16710414"}, {"database": "DOI", "id": "10.1038/nature04727"}], "title": "The DNA sequence and biological annotation of human chromosome 1.", "publicationDate": "2006", "journal": "Nature", "firstPage": "315", "lastPage": "321", "volume": "441"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519498.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519498.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL713999", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BHR8", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714215.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519498.1"}, {"key": "GeneId", "value": "ENSG00000116521.12"}]}, {"database": "HGNC", "id": "HGNC:10565", "properties": [{"key": "GeneName", "value": "SCAMP3"}]}, {"database": "OpenTargets", "id": "ENSG00000116521", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000160917", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 1"}]}], "sequence": {"value": "MAQSRDGGNPFAEPSELDNPFQDPAVIQHRPSRQYATLDVYNPFETREPPPAYEPPAPAPLPPPSAPSLQPSRKLSPTEPKNYGSYSTQASAAAATAELLKKQEELNRKAEELDRRERELQHAALGGTARHLHGDPPRISEDCIHHVLPLDVQHAGSSPELPRLPGQLLCGNQQWRRLWAFYPLGPPFHSLLLCLLVPPHV", "length": 201, "molWeight": 22279, "crc64": "A05F34BDC3603160", "md5": "21A3325C93FE4439EA2FB9548C6AC255"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Coiled coil": 1, "Compositional bias": 1}, "uniParcId": "UPI0032D16151"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9H862", "uniProtkbId": "A0AAT9H862_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFN35242.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFN35242.1"}], "value": "Parafibromin"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFN35242.1"}], "value": "CDC73"}}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "Paf1 complex subunit Cdc73 N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF16050"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-CD2DV2BSEJUEO", "citationType": "submission", "authors": ["Ishida Y.", "Hirose R."], "title": "A novel Pathogenic CDC73 Gene Variant in Hyperparathyroidism Jaw Tumor Syndrome.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFN35242.1"}], "value": "1-SY-2023", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFN35242.1"}], "value": "Blood", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFN35242.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC822793", "properties": [{"key": "ProteinId", "value": "BFN35242.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "PeptideAtlas", "id": "A0AAT9H862", "properties": [{"key": "Description", "value": "-"}]}, {"database": "InterPro", "id": "IPR032041", "properties": [{"key": "EntryName", "value": "Cdc73_N"}]}, {"database": "Pfam", "id": "PF16050", "properties": [{"key": "EntryName", "value": "CDC73_N"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSGPRM", "length": 35, "molWeight": 3998, "crc64": "179F1490DCE59AD9", "md5": "47E3536954194264D7A51858C66C45AC"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D2E738"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1H4", "uniProtkbId": "A0AAU7P1H4_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30754.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30754.1"}], "value": "Endothelial nitric oxide synthase"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30754.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 46, "modifier": "EXACT"}, "end": {"value": 46, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30754.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-3THMMO2GJQNJE", "citationType": "submission", "authors": ["Amjad A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30754.1"}], "value": "#1 rs2070744", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30754.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892410", "properties": [{"key": "ProteinId", "value": "XBS30754.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "ARVELDALVGAWGTRETTVPRMQVGYTSTLQALQARVHAGVCSSVS", "length": 46, "molWeight": 4874, "crc64": "8348FAEB712EF28A", "md5": "6499CDCAC94D5A720E9AD3646552400E"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D364FD"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTW8", "uniProtkbId": "A0AAT9UTW8_HUPSR", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Huperzia serrata", "commonName": "Toothed club-moss", "synonyms": ["Lycopodium serratum"], "taxonId": 355589, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM01282.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Lycopodiopsida", "Lycopodiales", "Lycopodiaceae", "Huperzioideae", "Huperzia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM01282.1"}], "value": "APETALA2-3"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM01282.1"}], "value": "AP2-3"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00037973"}], "value": "Belongs to the AP2/ERF transcription factor family. AP2 subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 96, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "AP2/ERF", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51032"}]}, {"type": "Domain", "location": {"start": {"value": 188, "modifier": "EXACT"}, "end": {"value": 245, "modifier": "EXACT"}}, "description": "AP2/ERF", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51032"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 70, "modifier": "EXACT"}, "end": {"value": 97, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7LM1KKJLVRMLE", "citationType": "submission", "authors": ["Lei M.", "Li C.", "Zhang Z.-j.", "Ou X.-l.", "Chen X.-y."], "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM01282.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR103132", "properties": [{"key": "ProteinId", "value": "WIM01282.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00018", "properties": [{"key": "EntryName", "value": "AP2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.730.10:FF:000004", "properties": [{"key": "EntryName", "value": "AP2-like ethylene-responsive transcription factor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.730.10", "properties": [{"key": "EntryName", "value": "AP2/ERF domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001471", "properties": [{"key": "EntryName", "value": "AP2/ERF_dom"}]}, {"database": "InterPro", "id": "IPR036955", "properties": [{"key": "EntryName", "value": "AP2/ERF_dom_sf"}]}, {"database": "InterPro", "id": "IPR016177", "properties": [{"key": "EntryName", "value": "DNA-bd_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR32467", "properties": [{"key": "EntryName", "value": "AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR32467:SF118", "properties": [{"key": "EntryName", "value": "ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR RAP2-7"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00847", "properties": [{"key": "EntryName", "value": "AP2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00367", "properties": [{"key": "EntryName", "value": "ETHRSPELEMNT"}]}, {"database": "SMART", "id": "SM00380", "properties": [{"key": "EntryName", "value": "AP2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF54171", "properties": [{"key": "EntryName", "value": "DNA-binding domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS51032", "properties": [{"key": "EntryName", "value": "AP2_ERF"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MPEASSAASTIDTISEGTREKSEDSAMFVTRELFPLQPSGPSSSLPDNVKKSASAFTHYVGLNLFQTEPCSRPKSVEASPPASKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDNGKQVYLGGFDTSHTAARAYDKAAIKFRGLDADINFNIKDYEEDIRQMGALKKEEFVHILRRQSTGFSRGSSKFRGVTLHKCGRWEARMGQFLGKKYIYLGLFDSEVEAARAYDKAAIRCNGREAVTNFDPSTYEKEIPSEDQRNDNITSHGVNQWNLQLGVSLAEGASQANLHLNEIGKSSESLSLCSSFSEHDWKKARLSNPPVQQSVDKVEGMPLSFTGMEWQRVSDCHPGRIEGDPTRRLQYFTSLSDAWSLPDIQNEHENAREALKLAALPGVQRKLSHATNLETFSDGQRQTCEILNFQPGNVFVPGISMRDKGLSLSHGATSADTRCYDEVDVSSFKVPSLPLKGPKDQRSEFQLIPSISVGSQPGWSWPVNKTFQPLASVLNSSIAPSVSNKITHPPSFQMLQKVDLDHTNQTFLTFPPSKMVFSSQNVYRRRGLGSNHKTKNFLGLSHDSPLS", "length": 577, "molWeight": 64312, "crc64": "12853D18269BB7B7", "md5": "82A789473A842AEC09931AEB1064676A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2, "Region": 2}, "uniParcId": "UPI0035D2B45B"}, "cluster_size": 1, "family": "Lycopodiaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N810", "uniProtkbId": "A0AAN0N810_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34074.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34074.1"}], "value": "Glutamate receptor ionotropic kainate 2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034104"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 983, "modifier": "EXACT"}, "end": {"value": 1002, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1059, "modifier": "EXACT"}, "end": {"value": 1080, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1245, "modifier": "EXACT"}, "end": {"value": 1269, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 175, "modifier": "EXACT"}, "end": {"value": 202, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 203, "modifier": "EXACT"}, "end": {"value": 232, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Domain", "location": {"start": {"value": 233, "modifier": "EXACT"}, "end": {"value": 260, "modifier": "EXACT"}}, "description": "C2H2-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50157"}]}, {"type": "Region", "location": {"start": {"value": 106, "modifier": "EXACT"}, "end": {"value": 133, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 106, "modifier": "EXACT"}, "end": {"value": 121, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 938, "modifier": "EXACT"}, "end": {"value": 938, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 943, "modifier": "EXACT"}, "end": {"value": 943, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 1110, "modifier": "EXACT"}, "end": {"value": 1110, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 1111, "modifier": "EXACT"}, "end": {"value": 1111, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 1158, "modifier": "EXACT"}, "end": {"value": 1158, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Site", "location": {"start": {"value": 1089, "modifier": "EXACT"}, "end": {"value": 1089, "modifier": "EXACT"}}, "description": "Crucial to convey clamshell closure to channel opening", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Site", "location": {"start": {"value": 1116, "modifier": "EXACT"}, "end": {"value": 1116, "modifier": "EXACT"}}, "description": "Interaction with the cone snail toxin Con-ikot-ikot", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1170, "modifier": "EXACT"}, "end": {"value": 1226, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34074.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00042"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34074.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155000", "properties": [{"key": "ProteinId", "value": "WRW34074.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0022824", "properties": [{"key": "GoTerm", "value": "F:transmitter-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0007166", "properties": [{"key": "GoTerm", "value": "P:cell surface receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "CDD", "id": "cd06382", "properties": [{"key": "EntryName", "value": "PBP1_iGluR_Kainate"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000167", "properties": [{"key": "EntryName", "value": "Eye-enriched kainate receptor, isoform B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000060", "properties": [{"key": "EntryName", "value": "Glutamate receptor ionotropic, kainate 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000001", "properties": [{"key": "EntryName", "value": "Glutamate receptor ionotropic, kainate 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.287.70:FF:000010", "properties": [{"key": "EntryName", "value": "Putative glutamate receptor ionotropic kainate 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000072", "properties": [{"key": "EntryName", "value": "zinc finger protein 143 isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000624", "properties": [{"key": "EntryName", "value": "zinc finger protein 697"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.160.60:FF:000257", "properties": [{"key": "EntryName", "value": "ZXD family zinc finger C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.30.160.60", "properties": [{"key": "EntryName", "value": "Classic Zinc Finger"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR001508", "properties": [{"key": "EntryName", "value": "Iono_Glu_rcpt_met"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "InterPro", "id": "IPR036236", "properties": [{"key": "EntryName", "value": "Znf_C2H2_sf"}]}, {"database": "InterPro", "id": "IPR013087", "properties": [{"key": "EntryName", "value": "Znf_C2H2_type"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00096", "properties": [{"key": "EntryName", "value": "zf-C2H2"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PRINTS", "id": "PR00177", "properties": [{"key": "EntryName", "value": "NMDARECEPTOR"}]}, {"database": "SMART", "id": "SM00918", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00355", "properties": [{"key": "EntryName", "value": "ZnF_C2H2"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SUPFAM", "id": "SSF57667", "properties": [{"key": "EntryName", "value": "beta-beta-alpha zinc fingers"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00028", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_1"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS50157", "properties": [{"key": "EntryName", "value": "ZINC_FINGER_C2H2_2"}, {"key": "MatchStatus", "value": "3"}]}], "sequence": {"value": "MATTINDEKNYLLNENKNNNNRIFRPWDCAIEDNSSKVISNNVNKTLASSLKTNKYCLPKVNNEYLTEMFNSNCTMNQNSIKTMDYLYSQLYKDYVLTKNLSLNHSENLKNPQQKVSTKQTSENDFKKNETSSNEKLISNKVKLIQNKLNPNESEKKFFVFDKNLGNKKQRPKKFRCPYCNIAFSNNGQLKGHIRTHTGERPFVCDNPNCGKTFTRNEELTRHRRIHTGLRPFACQICTKKFGRKDHLKKHQRTHERKMAMTKNTNQVNSASCFLSKQYSMNTNFSSLKNKMTNKNNLIFDVSKNEKLLKSTDNSITKNKIENNFPMLLNTNSIIDPYIYQISSLPNNNLQKKYSEEFSKNCLLFENDVKKIINQPSVSTINTLGNINSNTENSISKNTVTVDIFSSKLSNLNNSFFNIDQPINHQLINKTKISSSSSTSSESSYLSNSSFITPLNSSIDSLPQLPINTLPLSALFTDNHKNGPSELAFKYAVYRINKDRTILPNTTLIYDIQYTPKEDSFHAAKRACLQVSNGVSAIFGPQDALLGVHIQSLCDALEIPHLEARLDLEPQVKEVSINLYPNAEIIGNALRDLINYLNWTRVAVIYEEDISLIKLQSLVNPPMKKSVQITFRKATPDQFRDTLLDIRTRGIYSMIIDTKPENLPLFLSAILQIQMNNYKYHYHFATFDIETYNLNNFKYNFVNMTAFRIVDSEHINVQNVLEHMKMFQPIDQSVLNVSNVIRHEPALLYDSVYAFAHGVNSLLRSASFSPNNISCDQEIPWSEGSSLFNYVNSADFYGLTGKVQFKEGQRSALKLDLLKLRTDKLDKVGEWTISNKLNISNHNAFHEFGTQNITLRVTTIETIPYVMVKPGNYTGNDRFEGFCIDLLDAIAHNLGFQYELYFVPDGKFGAENTTTGEWNGLVREIIDKNADLAVAAMTINYVRESVIDFTKPFMNLGIGILFKLPSTMPTKLFSFMSPLDVDIWLYILAAYMLVSVTMFVIARFSPYEWHPMHPCVSTQEDMLENQFSLSNSFWFSTVCLLHQSSDLNPLATSTRIVSAIWWFFTLILVSSYTANLAAFLTVERMITPIESVEDLASQSKIQYGTLDSGSTMTFFRDSRMPTYQKMWRFMENRPNLFLTSYEQGKNRVLEGNFAFLMESTMLDYMVQRDCNLIQIGSLLDSKGYGIATPIGSPWRDKISLMILDLQEKGVIQLLYNKWWKNPGATCVRDDKNKEGKANALGVENIGGVFVVLLGGLLIAIIVAFIEFLCRSKKADYIQKSSLCSAIGEELRFAVKCRASKHRPRLHRSCSNCLDEKDAFVKDNSGVATLDEFNRKTQSCMNINQEDETGNTYVPNLGTSLELISSNTNLYYNQMKSKIPHTANVTPVLKKSNLHHRNLIKNCENVKSKNNINYHQTKYLQKRDNFYRSMNCENRNQNQCEDNCVCEQFFIDSHT", "length": 1454, "molWeight": 166331, "crc64": "317DE08DE91BC3BB", "md5": "BB380285AEAA17A4ADDC66C216ADF968"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 3, "Domain": 3, "Region": 1, "Compositional bias": 1, "Binding site": 5, "Site": 2, "Disulfide bond": 1}, "uniParcId": "UPI00325106AE"}, "cluster_size": 2, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7YE02", "uniProtkbId": "A0AAU7YE02_NIDPL", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Nidirana pleuraden", "commonName": "Yunnan pond frog", "synonyms": ["Babina pleuraden"], "taxonId": 369511, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87689.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Amphibia", "Batrachia", "Anura", "Neobatrachia", "Ranoidea", "Ranidae", "Nidirana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87689.1"}], "value": "Amplexin 15"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 133, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043537764"}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87689.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 133, "modifier": "EXACT"}, "end": {"value": 133, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87689.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "38891597", "citationType": "journal article", "authors": ["Zheng P.", "Gong Y.", "Wang B.", "Yu H.", "Huang S.", "Liao X.", "Jiang J.", "Ran J.", "Xie F."], "citationCrossReferences": [{"database": "PubMed", "id": "38891597"}], "title": "Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.", "publicationDate": "2024", "journal": "Animals (Basel)", "firstPage": "0", "lastPage": "0", "volume": "14"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87689.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-E24AGF4876IHP", "citationType": "submission", "authors": ["Zheng P."], "publicationDate": "APR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBY87689.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP623150", "properties": [{"key": "ProteinId", "value": "XBY87689.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR045860", "properties": [{"key": "EntryName", "value": "Snake_toxin-like_sf"}]}, {"database": "SUPFAM", "id": "SSF57302", "properties": [{"key": "EntryName", "value": "Snake toxin-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "SSLQSLQNVIMKAAITLLILGLLFIYGEARKCHNEVECNSKGKCSNVTICQPVVQPMVPIRKPLECIFQECIPEDKCRRHITFCRNGPDQCFFLMDARSYPRMGCATAAQCEKMKKLYPSSAYCCNTNNCNDP", "length": 133, "molWeight": 14991, "crc64": "4B89B2D95E9AEEFC", "md5": "8F5B0ADD106A6D29E242544DDBAFA9B2"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D36395"}, "cluster_size": 5, "family": "Ranidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA95ZA63", "uniProtkbId": "A0AA95ZA63_PSIGU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Psidium guajava", "commonName": "Guava", "synonyms": ["Psidium pyriferum"], "taxonId": 120290, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01968.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "malvids", "Myrtales", "Myrtaceae", "Myrtoideae", "Myrteae", "Pimenta group", "Psidium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01968.1"}], "value": "Terpene synthase"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001946"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}]}, {"commentType": "COFACTOR", "cofactors": [{"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001936"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 166, "modifier": "EXACT"}}, "description": "Terpene synthase N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF01397"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023239"}], "id": "KW-0456", "category": "Molecular function", "name": "Lyase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022842"}], "id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023211"}], "id": "KW-0464", "category": "Ligand", "name": "Manganese"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FCTKIOK6O0LM0", "citationType": "submission", "authors": ["Canal D.", "dos Santos P.H.D.", "Carpinetti-Oliveira P.A.", "Silva M.A.", "Fernandes M.", "Brustolini O.J.B.", "Ferreira A.", "Ferreira M.F.S."], "title": "Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01968.1"}], "value": "Pg44627", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNI01968.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR232576", "properties": [{"key": "ProteinId", "value": "WNI01968.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0010333", "properties": [{"key": "GoTerm", "value": "F:terpene synthase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016114", "properties": [{"key": "GoTerm", "value": "P:terpenoid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.600.10", "properties": [{"key": "EntryName", "value": "Farnesyl Diphosphate Synthase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.50.10.130", "properties": [{"key": "EntryName", "value": "Terpene synthase, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008949", "properties": [{"key": "EntryName", "value": "Isoprenoid_synthase_dom_sf"}]}, {"database": "InterPro", "id": "IPR001906", "properties": [{"key": "EntryName", "value": "Terpene_synth_N"}]}, {"database": "InterPro", "id": "IPR036965", "properties": [{"key": "EntryName", "value": "Terpene_synth_N_sf"}]}, {"database": "InterPro", "id": "IPR050148", "properties": [{"key": "EntryName", "value": "Terpene_synthase-like"}]}, {"database": "InterPro", "id": "IPR008930", "properties": [{"key": "EntryName", "value": "Terpenoid_cyclase/PrenylTrfase"}]}, {"database": "PANTHER", "id": "PTHR31225:SF245", "properties": [{"key": "EntryName", "value": "(-)-ALPHA-TERPINEOL SYNTHASE-LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31225", "properties": [{"key": "EntryName", "value": "OS04G0344100 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF19086", "properties": [{"key": "EntryName", "value": "Terpene_syn_C_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01397", "properties": [{"key": "EntryName", "value": "Terpene_synth"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48239", "properties": [{"key": "EntryName", "value": "Terpenoid cyclases/Protein prenyltransferases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48576", "properties": [{"key": "EntryName", "value": "Terpenoid synthases"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MALPSLFTSFLPPSIGHKPSLSFFRHRRFCSSSSASFGSRFGICTSKIQDQEIIRRSANWQPSVWDYDFVQSLSVDHTDKYAEQVQRLKEEVKGLFDKEMNHVAKLEFIDVVQRLGLGYHFQTEIKDALRSIHSKTKDAQLFDDLYATSLQFRLLRQHGYDVPQDVDRLPPTIRDSFMVLYNTTNEVGYWTMRERGINPIPYLRKVHELARGDNPKALECYMNETGVSEEVARQHIRHLVRKTWKKLNKEVFEDYPFSGFGPFLGACLNLARASHCFYDYGDGHGLPGHHTKDHIVSTIFESVSP", "length": 305, "molWeight": 35223, "crc64": "3378E8494769CD7B", "md5": "1FE6CE9E818BDE63CCBB0205AF45A767"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 2}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI002B2F73C8"}, "cluster_size": 1, "family": "Myrtaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEG7", "uniProtkbId": "A0AB38ZEG7_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71795.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71795.1"}], "value": "Venom redulysin 7"}}], "flag": "Fragment"}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 35, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 382, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044218466"}, {"type": "Region", "location": {"start": {"value": 183, "modifier": "EXACT"}, "end": {"value": 212, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 109, "modifier": "EXACT"}, "end": {"value": 140, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 221, "modifier": "EXACT"}, "end": {"value": 248, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 382, "modifier": "EXACT"}, "end": {"value": 382, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71795.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71795.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510870", "properties": [{"key": "ProteinId", "value": "WXH71795.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MRILPVIGESSPNKVTMSKLWLLLLLVAAFQTAQSFPTNDDNLEDSETTASILKDTWGKLKVLYTEKGKEAVKVILAKLKEKLCTQNDFEEDVDYAEEDGEETIASKLLTKIRETMKKVKQAVGEKKEQLKQELEKLRVKLCNSQIEDVEEDEEEFFNDYEEEDGDEERGFGKFVSKTASKSGSKAASSAGKKAASSAGKKAASSAGKKATSTAKKSTSIADKFNNALEKGKKKLKKLKEKAKSCMKKGREFLKNAGVKVEILKCKEKTCSSCVSFLTKKICMDMRFMRTNKATSVIFTFIFLGEVVKEIRVNLGDVPRCVEIGGFVGKICLKAIEGRVKTSDGKVKCNFCMGILSDTFGAGVKMCATYEDKKLKFKFSPKM", "length": 382, "molWeight": 42375, "crc64": "D551608812AF00DE", "md5": "E15CAD924911EB13FAA30775E9B68173"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 1, "Coiled coil": 2, "Non-terminal residue": 1}, "uniParcId": "UPI00388C0777"}, "cluster_size": 2, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QP57", "uniProtkbId": "A0AAU0QP57_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56496.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56496.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 15, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56496.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56496.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56496.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56496.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970389", "properties": [{"key": "ProteinId", "value": "WPO56496.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "GSLLFHISAGYGFDLRYTFFSFISVVHIFLPCKYAAELKMMSTETATMIYCSGWEKVISKRVAKVVPFLVARAQIPVRIKFFMFEYNMELFINILRTSYSMFTLLRS", "length": 107, "molWeight": 12478, "crc64": "C3242680ADB43C90", "md5": "44DFFBCAB54DDDFDD1658208A2F399EE"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 1}, "uniParcId": "UPI003086C900"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN67", "uniProtkbId": "A0AA96MN67_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50100.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50100.1"}], "value": "Deleted in malignant brain tumors 1 protein-like protein 2"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004308"}], "value": "Endomembrane system", "id": "SL-0147"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004167"}], "value": "Single-pass membrane protein", "id": "SL-9904"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 986, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041714059"}, {"type": "Domain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 144, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 152, "modifier": "EXACT"}, "end": {"value": 259, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 267, "modifier": "EXACT"}, "end": {"value": 374, "modifier": "EXACT"}}, "description": "SRCR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50287"}]}, {"type": "Domain", "location": {"start": {"value": 402, "modifier": "EXACT"}, "end": {"value": 502, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Domain", "location": {"start": {"value": 560, "modifier": "EXACT"}, "end": {"value": 648, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Domain", "location": {"start": {"value": 599, "modifier": "EXACT"}, "end": {"value": 927, "modifier": "EXACT"}}, "description": "Protein kinase", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50011"}]}, {"type": "Domain", "location": {"start": {"value": 670, "modifier": "EXACT"}, "end": {"value": 760, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 98, "modifier": "EXACT"}, "end": {"value": 108, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 227, "modifier": "EXACT"}, "end": {"value": 237, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 340, "modifier": "EXACT"}, "end": {"value": 350, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00196"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023319"}], "id": "KW-0393", "category": "Domain", "name": "Immunoglobulin domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022777"}], "id": "KW-0418", "category": "Molecular function", "name": "Kinase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023137"}], "id": "KW-0829", "category": "Molecular function", "name": "Tyrosine-protein kinase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50100.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460177", "properties": [{"key": "ProteinId", "value": "WNS50100.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0012505", "properties": [{"key": "GoTerm", "value": "C:endomembrane system"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004713", "properties": [{"key": "GoTerm", "value": "F:protein tyrosine kinase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0048468", "properties": [{"key": "GoTerm", "value": "P:cell development"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0050793", "properties": [{"key": "GoTerm", "value": "P:regulation of developmental process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "3.10.250.10:FF:000001", "properties": [{"key": "EntryName", "value": "Lysyl oxidase 4 isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.510.10:FF:001512", "properties": [{"key": "EntryName", "value": "Receptor tyrosine-protein kinase erbB-2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.10.250.10:FF:000031", "properties": [{"key": "EntryName", "value": "RIKEN cDNA 5830411N06, isoform CRA_a"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.10.250.10:FF:000009", "properties": [{"key": "EntryName", "value": "WC1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "3.10.250.10", "properties": [{"key": "EntryName", "value": "SRCR-like domain"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "1.10.510.10", "properties": [{"key": "EntryName", "value": "Transferase(Phosphotransferase) domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR003598", "properties": [{"key": "EntryName", "value": "Ig_sub2"}]}, {"database": "InterPro", "id": "IPR011009", "properties": [{"key": "EntryName", "value": "Kinase-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR000719", "properties": [{"key": "EntryName", "value": "Prot_kinase_dom"}]}, {"database": "InterPro", "id": "IPR001245", "properties": [{"key": "EntryName", "value": "Ser-Thr/Tyr_kinase_cat_dom"}]}, {"database": "InterPro", "id": "IPR001190", "properties": [{"key": "EntryName", "value": "SRCR"}]}, {"database": "InterPro", "id": "IPR036772", "properties": [{"key": "EntryName", "value": "SRCR-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR008266", "properties": [{"key": "EntryName", "value": "Tyr_kinase_AS"}]}, {"database": "InterPro", "id": "IPR020635", "properties": [{"key": "EntryName", "value": "Tyr_kinase_cat_dom"}]}, {"database": "PANTHER", "id": "PTHR48071:SF18", "properties": [{"key": "EntryName", "value": "DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48071", "properties": [{"key": "EntryName", "value": "SRCR DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13927", "properties": [{"key": "EntryName", "value": "Ig_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07714", "properties": [{"key": "EntryName", "value": "PK_Tyr_Ser-Thr"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00530", "properties": [{"key": "EntryName", "value": "SRCR"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PRINTS", "id": "PR00258", "properties": [{"key": "EntryName", "value": "SPERACTRCPTR"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00408", "properties": [{"key": "EntryName", "value": "IGc2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00202", "properties": [{"key": "EntryName", "value": "SR"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SMART", "id": "SM00219", "properties": [{"key": "EntryName", "value": "TyrKc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SUPFAM", "id": "SSF56112", "properties": [{"key": "EntryName", "value": "Protein kinase-like (PK-like)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF56487", "properties": [{"key": "EntryName", "value": "SRCR-like"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS50011", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00109", "properties": [{"key": "EntryName", "value": "PROTEIN_KINASE_TYR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50287", "properties": [{"key": "EntryName", "value": "SRCR_2"}, {"key": "MatchStatus", "value": "3"}]}], "sequence": {"value": "MSLLAAVVLLLLQLPGVEPIFVEVRVVDGQKSADNRSISGRVEVLYNNTWGTICDYYWDQRDATVVCKQLGYSEAIRPSRGAEYGRGTGTIWLEKVECDGDEENLGQCRHEGWGIHLRSRSVHIGWGVFSSVCDHSNDAGVVCSAEPILVDVRVVDSQKSADNWSLSGRVEVLYNNTWGTICADLSWNQEEVTVICKQLGYSEAIRSSLGAEYGRGTGPIWLSDVDCAGDEENLAQCRHGGWGVHYGCGHSDDVGVVCSAEPILVDVRVVDGQKSADNCSISGRVEVLYNNTWGTICGIVWHQGDATVVCKQLGYSEAIRPSRGAYGQGTGPVWLGYVSCAGDEENLTQCRHAGWGDDLSSWCDHSLDAGVVCSEIVAPPVFLNKTTVTDVVVINGSTIPAPELPMGTDVVISEVGKLTSLTFYCSLLNSGIPSANISWTVNGRSLISSRWFRSSLNVINSTDNTTSRLLVNVSNFKSSFLCCKAENIAGKDLLCSELKLLSAKSPKLSFQTFGSNALLVKDALVNNGTKSLLLPVVLGRWSCVCENKEGSINSSIHVGPCCEDVTFKIGAVHPVLAGFSFTIVCRVLQARPDPSVKWFRNGELLSNNTNQTTLRVHVNRSEPAAAAGDYRCTAENEVANDTAHSNMALGKEILILPRLLRSTKHYENMPENITVFFGDSSVVQRGKSVTIHCSVVDAGIPAQSELSWMDVKTLTVSKGVSWSNDGYLTIETALVNATDLRYCCTARNEAGSDTACSNITIEGVAVVMEFVPFGDLRSNLMKWKVESHLASLNVIHRDLACRNVLVGENKTLKVSDFGLSKEIDGMYTSTSKTKLPIRWMSPEAIRHRIFSQKSDVWSFGVCLWEICTLGEVPYSHLSSAEVAEAVDRSAYLRRPSSCHDDVYSLMLNCWKRAAAERPAFEDIEKYLADLITKNCHQNYISLESGFLPELEAEGVETEMKRSSSLPAVEPATVTSRVSLMVHHAAL", "length": 986, "molWeight": 107644, "crc64": "FC146732EB3CE9E6", "md5": "40A554ADD1E7F8B19E7571CD3A43530D"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 7, "Disulfide bond": 3}, "uniParcId": "UPI002B31AEEE"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MLT9", "uniProtkbId": "A0AA96MLT9_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50067.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00029496"}], "value": "Structure-specific endonuclease subunit SLX4"}}}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00006661"}], "value": "Belongs to the SLX4 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 875, "modifier": "EXACT"}, "end": {"value": 897, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 912, "modifier": "EXACT"}, "end": {"value": 934, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 946, "modifier": "EXACT"}, "end": {"value": 969, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 989, "modifier": "EXACT"}, "end": {"value": 1011, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 302, "modifier": "EXACT"}, "end": {"value": 365, "modifier": "EXACT"}}, "description": "BTB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50097"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 44, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 487, "modifier": "EXACT"}, "end": {"value": 515, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 560, "modifier": "EXACT"}, "end": {"value": 589, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 771, "modifier": "EXACT"}, "end": {"value": 802, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 7, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 493, "modifier": "EXACT"}, "end": {"value": 515, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 570, "modifier": "EXACT"}, "end": {"value": 588, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022763"}], "id": "KW-0227", "category": "Biological process", "name": "DNA damage"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023172"}], "id": "KW-0233", "category": "Biological process", "name": "DNA recombination"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023204"}], "id": "KW-0234", "category": "Biological process", "name": "DNA repair"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50067.1"}], "id": "KW-0255", "category": "Molecular function", "name": "Endonuclease"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50067.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50067.1"}], "id": "KW-0540", "category": "Molecular function", "name": "Nuclease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50067.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460144", "properties": [{"key": "ProteinId", "value": "WNS50067.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0033557", "properties": [{"key": "GoTerm", "value": "C:Slx1-Slx4 complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004519", "properties": [{"key": "GoTerm", "value": "F:endonuclease activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006281", "properties": [{"key": "GoTerm", "value": "P:DNA repair"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0006260", "properties": [{"key": "GoTerm", "value": "P:DNA replication"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000712", "properties": [{"key": "GoTerm", "value": "P:resolution of meiotic recombination intermediates"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd18186", "properties": [{"key": "EntryName", "value": "BTB_POZ_ZBTB_KLHL-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd22999", "properties": [{"key": "EntryName", "value": "SAP_SLX4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.710.10", "properties": [{"key": "EntryName", "value": "Potassium Channel Kv1.1, Chain A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000210", "properties": [{"key": "EntryName", "value": "BTB/POZ_dom"}]}, {"database": "InterPro", "id": "IPR011333", "properties": [{"key": "EntryName", "value": "SKP1/BTB/POZ_sf"}]}, {"database": "InterPro", "id": "IPR018574", "properties": [{"key": "EntryName", "value": "Structure-sp_endonuc_su_Slx4"}]}, {"database": "PANTHER", "id": "PTHR21541", "properties": [{"key": "EntryName", "value": "BTB POZ DOMAIN CONTAINING 12"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21541:SF3", "properties": [{"key": "EntryName", "value": "STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00651", "properties": [{"key": "EntryName", "value": "BTB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF09494", "properties": [{"key": "EntryName", "value": "Slx4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54695", "properties": [{"key": "EntryName", "value": "POZ domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50097", "properties": [{"key": "EntryName", "value": "BTB"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAPKLKLALKRSKSRQQGKQHPIELSLAPQVEPTSATALQELKTQEHDQCFQPKPSDDSDELDFRASKSSNVIPIVTLPDSRPQPKRPKRINAQVLSPLELDQIQLATALSKSEAPAGTMELSMVPRPKAKSKTAPKSLLESLTSDKVNQIISNRLDSVLEDSNVPPADASALGPSKLTRTEHFEPSSAVDVLMSHSAGVSSGSRLWSVAAYSESNPEENFYVEPLQPLIRSDTASVFDLDTMPCLQEVEDIKNAVNHQPPATPSQEDVCCSEFKAAAMQTDMLPSSCCSGFAGLQGSSFLSDTRVLLQSGASVPGHAAVLYTRWPLFRKMLSEAKPTSPSFITLDLQEHSPHLVQQLMDYLYTGSHGPDYDEMVQVFFNTLQTLSFTVSTTVLSNELQGDMDVSESLGGTSGLTMTHNVPDDFFCAMDESTFENKSESHNDVIIDLSASCFSSALGIGPHGVNNVSKPSSLPYSFTDTELLDQSLPLPSAVSKPSPSHETASSVSCSTAENNRPATDVRLTQSLPQLSSPGGNIESLAADEWLLLPVLPHLSAACPTSQVSEEELTGEVVSSSAEDGESDSVSNSGDSLADVRLSQDWLDFSLDCPQVDYLLSPMTLTYEQSAVQGLSVAAGTPLTSRITAPRSRDTPQQPPLAGTGDIIQGGSTPPDHHMMSCDIIRGGFTPPDHHMMSGDIIRGGSTPPDHHMMSAVTPGGLASSDAVTPMPDYRNMATPWLKGQMSKFGVRSLSKKKMIAKLIEIYEYLHPIIEDRSSSDVPDSAPAQSTDVDPMAGPGGKRKGRRNKKAEVDLCTCQNASAKDSTDIHTRIFHCIMNCEELYRDIILYKTVDLAEFRECLNQQGIKIANPKLMAYLDKQAATCTTVVAGMGWLLFVIGMGLFRDRGAGSELLGLNYAYYWGMAVGSPFSLIALLLHPFIIDLVKNLLVKIFWTFGFVVFLVWHFVFAGVVLSTASITIFDTNNLEGALTANDLGLIFTGALGSVIFAGVSTAILYARDFVQVEEVKYD", "length": 1023, "molWeight": 110700, "crc64": "AD0DF3D2B51493DD", "md5": "314AC41275AF647D9A71E873A9D79586"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 4, "Domain": 1, "Region": 5, "Compositional bias": 3}, "uniParcId": "UPI002B2A71C8"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6ND60", "uniProtkbId": "A0AAU6ND60_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59806.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59806.1"}], "value": "OR49a"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 54, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 86, "modifier": "EXACT"}, "end": {"value": 105, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59806.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 126, "modifier": "EXACT"}, "end": {"value": 126, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59806.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59806.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420166", "properties": [{"key": "ProteinId", "value": "WWA59806.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "DVLIYNFENMESLIKATAAERQCSEDEAFKEIFKRCILHHSSILRFVNTIQATFSGLLSATLFLSTGILGSTAVILFAIESPMKNLTDVIWILAYLVVFVGNLYIDCYFGNTITAKSLHISTVVFS", "length": 126, "molWeight": 14049, "crc64": "0B8897FE9A16E4BE", "md5": "1BBEE2E8E27C1061B0E1D6E725BE633E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 2, "Non-terminal residue": 2}, "uniParcId": "UPI0035D3327B"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAA9YHH4", "uniProtkbId": "A0AAA9YHH4_HUMAN", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518809.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518809.1"}], "value": "Family with sequence similarity 136 member A"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518809.1"}], "value": "FAM136A"}}], "features": [{"type": "Region", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 43, "modifier": "EXACT"}, "end": {"value": 52, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAA9YHH4"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAA9YHH4"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518809.1"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518809.1"}]}, {"referenceNumber": 3, "citation": {"id": "15815621", "citationType": "journal article", "authors": ["Hillier L.W.", "Graves T.A.", "Fulton R.S.", "Fulton L.A.", "Pepin K.H.", "Minx P.", "Wagner-McPherson C.", "Layman D.", "Wylie K.", "Sekhon M.", "Becker M.C.", "Fewell G.A.", "Delehaunty K.D.", "Miner T.L.", "Nash W.E.", "Kremitzki C.", "Oddy L.", "Du H.", "Sun H.", "Bradshaw-Cordum H.", "Ali J.", "Carter J.", "Cordes M.", "Harris A.", "Isak A.", "van Brunt A.", "Nguyen C.", "Du F.", "Courtney L.", "Kalicki J.", "Ozersky P.", "Abbott S.", "Armstrong J.", "Belter E.A.", "Caruso L.", "Cedroni M.", "Cotton M.", "Davidson T.", "Desai A.", "Elliott G.", "Erb T.", "Fronick C.", "Gaige T.", "Haakenson W.", "Haglund K.", "Holmes A.", "Harkins R.", "Kim K.", "Kruchowski S.S.", "Strong C.M.", "Grewal N.", "Goyea E.", "Hou S.", "Levy A.", "Martinka S.", "Mead K.", "McLellan M.D.", "Meyer R.", "Randall-Maher J.", "Tomlinson C.", "Dauphin-Kohlberg S.", "Kozlowicz-Reilly A.", "Shah N.", "Swearengen-Shahid S.", "Snider J.", "Strong J.T.", "Thompson J.", "Yoakum M.", "Leonard S.", "Pearman C.", "Trani L.", "Radionenko M.", "Waligorski J.E.", "Wang C.", "Rock S.M.", "Tin-Wollam A.M.", "Maupin R.", "Latreille P.", "Wendl M.C.", "Yang S.P.", "Pohl C.", "Wallis J.W.", "Spieth J.", "Bieri T.A.", "Berkowicz N.", "Nelson J.O.", "Osborne J.", "Ding L.", "Meyer R.", "Sabo A.", "Shotland Y.", "Sinha P.", "Wohldmann P.E.", "Cook L.L.", "Hickenbotham M.T.", "Eldred J.", "Williams D.", "Jones T.A.", "She X.", "Ciccarelli F.D.", "Izaurralde E.", "Taylor J.", "Schmutz J.", "Myers R.M.", "Cox D.R.", "Huang X.", "McPherson J.D.", "Mardis E.R.", "Clifton S.W.", "Warren W.C.", "Chinwalla A.T.", "Eddy S.R.", "Marra M.A.", "Ovcharenko I.", "Furey T.S.", "Miller W.", "Eichler E.E.", "Bork P.", "Suyama M.", "Torrents D.", "Waterston R.H.", "Wilson R.K."], "citationCrossReferences": [{"database": "PubMed", "id": "15815621"}, {"database": "DOI", "id": "10.1038/nature03466"}], "title": "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.", "publicationDate": "2005", "journal": "Nature", "firstPage": "724", "lastPage": "731", "volume": "434"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518809.1"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518809.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC022201", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000711613.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518809.1"}, {"key": "GeneId", "value": "ENSG00000035141.10"}]}, {"database": "HGNC", "id": "HGNC:25911", "properties": [{"key": "GeneName", "value": "FAM136A"}]}, {"database": "OpenTargets", "id": "ENSG00000035141", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00390000006707", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 2"}]}], "sequence": {"value": "MAELQQLRVQEAVESMVKSLERENIRKMQVSGPRPSRGAANVKDQKGEDFRPPRWPGSHVPVQRQLL", "length": 67, "molWeight": 7678, "crc64": "2B3BDF718C6279FB", "md5": "60AB38805A1609B4948B4C3236BC4542"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B4FF34A"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N805", "uniProtkbId": "A0AAN0N805_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34059.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34059.1"}], "value": "Metabotropic glutamate receptor-like protein"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00054813"}], "value": "G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors"}], "commentType": "FUNCTION"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007242"}], "value": "Belongs to the G-protein coupled receptor 3 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 624, "modifier": "EXACT"}, "end": {"value": 645, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 660, "modifier": "EXACT"}, "end": {"value": 680, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 692, "modifier": "EXACT"}, "end": {"value": 709, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 730, "modifier": "EXACT"}, "end": {"value": 752, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 772, "modifier": "EXACT"}, "end": {"value": 802, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 814, "modifier": "EXACT"}, "end": {"value": 836, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 842, "modifier": "EXACT"}, "end": {"value": 862, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 622, "modifier": "EXACT"}, "end": {"value": 884, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 3 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50259"}]}, {"type": "Region", "location": {"start": {"value": 1012, "modifier": "EXACT"}, "end": {"value": 1045, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1106, "modifier": "EXACT"}, "end": {"value": 1140, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1641, "modifier": "EXACT"}, "end": {"value": 1661, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1019, "modifier": "EXACT"}, "end": {"value": 1045, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1118, "modifier": "EXACT"}, "end": {"value": 1128, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1643, "modifier": "EXACT"}, "end": {"value": 1661, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022553"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34059.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34059.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154985", "properties": [{"key": "ProteinId", "value": "WRW34059.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0007206", "properties": [{"key": "GoTerm", "value": "P:phospholipase C-activating G protein-coupled glutamate receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "CDD", "id": "cd15285", "properties": [{"key": "EntryName", "value": "7tmC_mGluR_group1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.50.2300:FF:000219", "properties": [{"key": "EntryName", "value": "Glutamate metabotropic receptor 5"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "2.10.50.30:FF:000001", "properties": [{"key": "EntryName", "value": "metabotropic glutamate receptor 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "2.10.50.30", "properties": [{"key": "EntryName", "value": "GPCR, family 3, nine cysteines domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR000337", "properties": [{"key": "EntryName", "value": "GPCR_3"}]}, {"database": "InterPro", "id": "IPR011500", "properties": [{"key": "EntryName", "value": "GPCR_3_9-Cys_dom"}]}, {"database": "InterPro", "id": "IPR038550", "properties": [{"key": "EntryName", "value": "GPCR_3_9-Cys_sf"}]}, {"database": "InterPro", "id": "IPR017978", "properties": [{"key": "EntryName", "value": "GPCR_3_C"}]}, {"database": "InterPro", "id": "IPR017979", "properties": [{"key": "EntryName", "value": "GPCR_3_CS"}]}, {"database": "InterPro", "id": "IPR000162", "properties": [{"key": "EntryName", "value": "GPCR_3_mtglu_rcpt"}]}, {"database": "InterPro", "id": "IPR050726", "properties": [{"key": "EntryName", "value": "mGluR"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "PANTHER", "id": "PTHR24060", "properties": [{"key": "EntryName", "value": "METABOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00003", "properties": [{"key": "EntryName", "value": "7tm_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07562", "properties": [{"key": "EntryName", "value": "NCD3G"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00248", "properties": [{"key": "EntryName", "value": "GPCRMGR"}]}, {"database": "PRINTS", "id": "PR00593", "properties": [{"key": "EntryName", "value": "MTABOTROPICR"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00980", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F3_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00981", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F3_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50259", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F3_4"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKLICFMFLTKIKFICFYGHLPKTSQFWIQILIIICCSFKCDSIKNQYNKAVGTMTGDLVLGALFPVHHAPGPAQAQTRTCGEIREQYGIQRVEAAFQTIDLINKNKKILPGIVLGIEVRDSCWYSPIALEQSIEFIRDAMAASEEKQRREKELERLSAINLNENDFTEDYKNSSNCPKQASVKNFVGVIGPASSTVTIQVQNLLQLFNIPQIGYSATSRDLSTKNYYKYFLRVVPSDLLQAQVMIDLIKQNNWTYISAVYTDGNYGSSLMEVFKGLAQDEGICIANTESVFHNADDDKFDETVRSLQQYKTTAKVVACFCEGKTVRGILKAFKRLNATGEFMLVGSDGWSDRYDIVDSLEEESVGGLSVRIHSPYVHEFDEYYFNLNPFKNKRNPWFKEFWEWKFNCSLSETISNRTSKQCTGEEKLKEKYKQDSKMAFVIKSIWTMAYGLQSMFQSLCPNQTKLCDKMKPVNGSIFLQHLLNVSFEWKNEKVLFDQSGDPPGRYDIMNFQKKSNGSYAYEMIGTWDSTSSKLNITKQIHWPKYMESPPESVCSKPCKPGHAKNFQSDSVKCCWVCVPCRENQYLKNEFTCENCPIGWRPNSNLTDCLQIPVKYIQWTETPSLVAIAIAVIGLLMTLFTMAVFIKHNDTPVVKASTKELSYLIMIGMILANCTTFFLIARPTKFNCLVARILPGFSFAIIYGSLVTKTNRIARILAGSKKRILTKKPRFMSSTSQVFISCFLVCIEIAILAFTLIKEPADSMLDYPSWDKVILVCNTTSLGISAPMGFDYFLIAMCTLYAIKTRNVPENFNEAKFIGFTMYTTIVIWGAFFPIYFGSNTKVISLCLCISLSAIIALILLFFPKLYIIILKPEKNNRSFFTTTRDVRCHIGYVPTLGISRHSSHSASDFSFESPRTYSAEQHHQNFLHANILQEKGITGGFVEAAATRALLATTTNKKKKVSVNSSNTPLNSKSIFSFFTRLRYKKRDRIKANIDQKIRAVRAAEALDRQTNIRRSRFPSKQSSFKDNGAGENSHSSKGQFSSQNQIDTQKLKLINLWKHAYLNELAKIPGLLEFIDNYKDNYVLIGSNNSNKNKRAISMQLSSKAINNGNSDKNKENSINQQSSNNLSKEKLDTGVQTSFENSSEIKRENFEKIKGNSTSTNVYMVKKPSSKINQVLNVEGKKNLEFEKTIGELKQQTFQVEKKIKVQKNQSKLENISSEKLKILTDCDPEKENWSMDDNNNKKPQKNQHHFGNIDSLECVENENKNSFDCLDSVQLLPPPPPLVSSKLTCPSFQQKFSVLTQTESLDNETESYLNNHIDISNLETPNFGLSTAEELILRVNKLSAKPKNIAEDSLVKNSKKMSSFPVLRKTNSSNSNTQSTVRVQSRFQSSNINKNKSIELDSTNVISNLKNTKKPSISSIEKLELKNTSIKQLSKENQTYTTRDELNKNFSYHRRTPSWSETAFIRQNEKDSFHEQFVKMNFDQKGIVLNENKKEVNQFKSKESLVVEESASENDEDSSAAIYKKIIISLRNSSVDLTDNDYQFTRNHSQTCLNRSNLQQSFHQNISEESNHHHYCTHEPYHHLHHRHSNQANYATYYEQMQQLQNLEHEQSSLNEEYYYNNNFTRQINTIDGQEEEEINFSNISRSEPSSTRQSRKY", "length": 1661, "molWeight": 189720, "crc64": "28F380213F5740F5", "md5": "5E99D31843D1F999FE7D028D2A0FCA5F"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1, "Region": 3, "Compositional bias": 3}, "uniParcId": "UPI00325256BD"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UVI5", "uniProtkbId": "A0AAT9UVI5_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41710.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41710.1"}], "value": "Cytochrome P450 4461P1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 438, "modifier": "EXACT"}, "end": {"value": 438, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41710.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117270", "properties": [{"key": "ProteinId", "value": "WIM41710.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MIVVVLLGCLILPFLLNYVYTTKNRRFYQLLEEFPSYPTYPIIGNLDKVYGRSDDVLRKLEKCMQPYNRIVFWFATIPTLILKKYDDIMAVTNQCHDRDFYGFTLPWTDVGVVTARYDEWKKSRKMLAPAFSTEMLFKYVNVFNDKASALVDKFKSVADTDQEINVWEHTMATNMDIFLENMMGVSTTVDGESGKNFGEAWCIAFQCINQRLFAVWLRPFFINYVYLKITRKIKYLKQLHEFPEKLIEGTVADFRNGSKNFDDVCSSKTMIDLQVKKSLLDASITRKRMRDEISQIIGAGMETSSLNVCFTMLNLAINQDLQQKVYEEITQLPTENGILTFSQLSNDLKYLEQCIRETGRLYCVAVWSSRRTHKDCPLPDGKVIPAGTVILINLRWALTDEELYKNPHKWDPDRFSEEEVAKRPKGSDLVFGYGARSCIGTKYGIISVKTQLAHILREYHLSTSIKQLTAEDLTTDLMVRSKIGYPIKFTRRRNLQKN", "length": 498, "molWeight": 57712, "crc64": "A9867DDF2025B15F", "md5": "7A374D9179733ECAF7C296B7485DE132"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D2A873"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96NAL1", "uniProtkbId": "A0AA96NAL1_9MAGN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Corydalis yanhusuo", "taxonId": 458692, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT44093.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Ranunculales", "Papaveraceae", "Fumarioideae", "Corydalis"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT44093.1"}], "value": "CYP82BF1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004913"}], "value": "Alkaloid biosynthesis"}], "commentType": "PATHWAY"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004370"}], "value": "Membrane", "id": "SL-0162"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 33, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 478, "modifier": "EXACT"}, "end": {"value": 478, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7U5ELI1R3HKK0", "citationType": "submission", "authors": ["Liu X."], "publicationDate": "FEB-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNT44093.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ434215", "properties": [{"key": "ProteinId", "value": "WNT44093.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0033075", "properties": [{"key": "GoTerm", "value": "P:isoquinoline alkaloid biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000026", "properties": [{"key": "EntryName", "value": "Cytochrome P450 82C4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050651", "properties": [{"key": "EntryName", "value": "Plant_Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR47947:SF26", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47947", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 82C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEYYSSSSLQQWLSTLLLLLLISSITISFYLLIRRSRGTTPHGRPSPPKVPGAWPLIGHLHLLGGNHPLHIVLGTMSDKYGPIFTMLFGKHPSLVVSSSQFAKECFTSTNDKLFSYRHVPTGVKHMFYNNDSFGFAPYGSYWREMRKMNSLSLFSHHRVERLNRIRTFQLNIWFKNLYEMCNKEKSTTSTEGVVVEMKSWFDEMFFHVLVNMIVKPTNDDEGLVNKYRDVAKEAGHLLSSMAVSDMVPSLGWLDHLFGLVSKMKKTAKDMDSILTTWLEQHKSSQQLRSNGRADQTEEEKEEEKGLIAELLSMPDSALFGHNRDIVIKSACQALIMAGSDSTSATLTWVLSLLLNHREVLKKAQKELDQVVGKDRQVDDSDIKDLVYLQAILKETMRLYPTAPILERLAVEDCIVGGFHVQAGTTLFVNVSKVQRDPNLWTDPSEFEPERFLTGSNADVDLKGQDYELIPFGSGRRSCPAVSFSVRIMLLVLALFIHSFEVKLVGDGILDMTESSGHTNCRSSPLEVLISPRLDSKIYG", "length": 539, "molWeight": 60877, "crc64": "15C3FC1D2B0EBE60", "md5": "B80F059760A060A40D36B90B88E28FD8"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "PATHWAY": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI002B28B66E"}, "cluster_size": 1, "family": "Papaveraceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLP3", "uniProtkbId": "A0AAU0QLP3_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56478.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56478.1"}], "value": "Odorant receptor"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 39, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56478.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56478.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56478.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970371", "properties": [{"key": "ProteinId", "value": "WPO56478.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MVKPGSRFAANLMRKLREVKKRAIFFWMVIIGNGVVYFIKPCLMSGRHLMEDYFIIYGNNSFSSFFYAS", "length": 69, "molWeight": 8096, "crc64": "CA50A2CB5335DF90", "md5": "0A945338FD035ADC6DF1364E1B54A826"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI0030913435"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI67", "uniProtkbId": "A0AA96MI67_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50069.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50069.1"}], "value": "Reverse transcriptase domain-containing protein"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 65, "modifier": "EXACT"}, "end": {"value": 93, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 590, "modifier": "EXACT"}, "end": {"value": 622, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 849, "modifier": "EXACT"}, "end": {"value": 868, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 913, "modifier": "EXACT"}, "end": {"value": 932, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1297, "modifier": "EXACT"}, "end": {"value": 1342, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 706, "modifier": "EXACT"}, "end": {"value": 737, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 953, "modifier": "EXACT"}, "end": {"value": 1148, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 1254, "modifier": "EXACT"}, "end": {"value": 1291, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 65, "modifier": "EXACT"}, "end": {"value": 76, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 81, "modifier": "EXACT"}, "end": {"value": 93, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 600, "modifier": "EXACT"}, "end": {"value": 614, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 849, "modifier": "EXACT"}, "end": {"value": 860, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1297, "modifier": "EXACT"}, "end": {"value": 1320, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50069.1"}], "id": "KW-0548", "category": "Molecular function", "name": "Nucleotidyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50069.1"}], "id": "KW-0695", "category": "Molecular function", "name": "RNA-directed DNA polymerase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50069.1"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50069.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460146", "properties": [{"key": "ProteinId", "value": "WNS50069.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0003964", "properties": [{"key": "GoTerm", "value": "F:RNA-directed DNA polymerase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "PANTHER", "id": "PTHR47027", "properties": [{"key": "EntryName", "value": "REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47027:SF20", "properties": [{"key": "EntryName", "value": "REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MCPPLSSSGVLLKIIIFSLYNNTTEGTRLILFKVVDALINERGFLNMDPGVRVCNSLIEAALRDSRPEIKEERQSDESPEEPTSQSANETQSDFSARSFLDQEFWAGSDQLGDKLMQACILSEGFESILSKKSEELPYVLFPASSSASIEKTGSVVGGSKKLTSLCQSVECALVLFNLHAVWNAEDQTSMKNLENLVIMSSDSAVASAYAANYLVRVKNASSEPANAPAPPPEAPEEEAPLKAFVDLVRVLGFAPPKSDQNIHRMMSTTLSVVETADLLFLYTDSSFFVLLGCFGFLMVSRLVTFDQLSTEWLYSVLAVVVMSGTPSPPLLAGKVNNLRSSIPGKVFAKAILNRLKPRAEQLLHKGQCGFRRGRGCADQLFSLRVLMEKAREYRKPFYACFIDLRKAYDSVHRDSLWRILEHSYHPPEKLLSIIRALHADCTAAVRTYGKTFPVEFVRHVKFSDIMLWMLHTFCDLLGSLMDDVGKEGDPGTMQMVKWDQFSICDHYHSKMHLYMLNLLSDVPLLDLVVCTVENSCRKMLSQTGVPPAATAAQGSSSDINVTPQANKKEGVYALCKRAISKPESAAFAFSNTASRKRQHQQSQVDPQEASSTAPTDPPNKRSPFLKLAEFAMECLHYKFTSVKTPVVKEFLTSGVSVNAVESLSRVLICVYTDKNLSLVKDLPELSTLRDLTSLVLDELVEAGLFANKHEEQKEWQKELIENLAKDYQKKLKQLHQDDPQLRQVLHQYYLQRDQDNLQRQRDNRQLRQAQCQEHQKLLDMLKHRHSSMRQMLYTDFQFLRRMLQETHPQPLVWERYRQVLDVMYECRLELLVQQHQQLKHQLKMQHQQLEHQLDQQHQHLEQQLQNSQQVRHAFETMAQNLLKWHKQRESEGWEEKEKGRQWKLQQQQKKLEKQQQEQTQAQKKPREMHQLQPQPQLVRDQILLQQKLHQNYLKQQQQQQQQQQQQLQHQQQQHQQQQQLQHQQQQHQQLQHQQQQHQQQQQLQHQQQQQLQHQQQQQLQHQQQQQLQQQQLQHQQQQQQQQQPQQQQQQQLQQQQQQQQLEHQQQKELQDELQHHMQCREQLIENLRKNYQKKLEQLRQDDPQLRQVLHQDYLQRDQDNLQRQRDNLQLWQAQRQEHEQLLDMLQHQRNSVQPMLYADFQYLLRMLQGDHLQPLVWDECRLELLVPQYQQLEDQLKMQHQQLEHQFDQQHQHLKQQLQNPLQQVRHVFETMEQNLLEWHRQRQSELLQGWEEKEEWRQLKLKLQQKKKRKNQQREQKQALEELREVHQWQPQPLQLQPQPQQLQPQQQQDLQQQMHQMQNAHEGRQQRWLNHRLQWPRQPE", "length": 1342, "molWeight": 158178, "crc64": "A57D150305DA5530", "md5": "FF83917C42D39195677C5FDF5605BE0B"}, "extraAttributes": {"countByFeatureType": {"Region": 5, "Coiled coil": 3, "Compositional bias": 5}, "uniParcId": "UPI002B325C3F"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0G1", "uniProtkbId": "A0AA96S0G1_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50105.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50105.1"}], "value": "Uncharacterized protein 29"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 31, "modifier": "EXACT"}, "end": {"value": 53, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 65, "modifier": "EXACT"}, "end": {"value": 82, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 113, "modifier": "EXACT"}, "end": {"value": 137, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 149, "modifier": "EXACT"}, "end": {"value": 172, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 192, "modifier": "EXACT"}, "end": {"value": 214, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 226, "modifier": "EXACT"}, "end": {"value": 252, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 258, "modifier": "EXACT"}, "end": {"value": 283, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50105.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460182", "properties": [{"key": "ProteinId", "value": "WNS50105.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MSSVSMAMLSLEYNNSNGSDTNSDMRLGPPIFLIVSSAVNLLSLLLLLPYIPVLRAAWKLPKSDMLPWIVLNLFLIAINTLGRSNVNLIKAISDSRLGHNEWMLSISSYCRSLLWSLTLSFVANNITPLVLALIEVVCLRRPGLASKQWLFNCVGSVGIWVVSLGMGVPFLFFTYRNAITCTETEYDYQYVIGVVNIFFYALAVYAVFLFYMTLSRQLIWKPSQIIAMEAMICALSLYNILITTTATVVVVSPSLSEILSSIAVGILGLVDLILNLSGLIIFCRYKEAQRLAKAMLPCCWRKCSVQPQN", "length": 309, "molWeight": 34389, "crc64": "724B7B1BFFB4FE82", "md5": "6D0AA424E6607887FCBB54F6751896D2"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 7}, "uniParcId": "UPI002B2DCD17"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJM2", "uniProtkbId": "A0AAU7LJM2_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28282.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28282.1"}], "value": "MADS87"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28282.1"}], "value": "MADS87"}}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "K-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51297"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28282.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28282.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400922", "properties": [{"key": "ProteinId", "value": "XBP28282.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR002487", "properties": [{"key": "EntryName", "value": "TF_Kbox"}]}, {"database": "Pfam", "id": "PF01486", "properties": [{"key": "EntryName", "value": "K-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51297", "properties": [{"key": "EntryName", "value": "K_BOX"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAKKIELLEASQKTLTFGRVLHRRLLGHDLDSCSLWEIQEIDDQLERSFCNIRARKNQLIVEQMEKLKEKKRRRPSSIVQEEREALTYYSSPSSSASHSHVETELFIGLPHIRC", "length": 114, "molWeight": 13349, "crc64": "6A6BE7FB4F8E437D", "md5": "719AFCE9A9219F53544C315FE5CB7BD3"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D376E1"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7N4", "uniProtkbId": "A0AAN0N7N4_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34072.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34072.1"}], "value": "Epithelial sodium channel/degenerin-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007193"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "value": "Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 459, "modifier": "EXACT"}, "end": {"value": 485, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 308, "modifier": "EXACT"}, "end": {"value": 336, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 317, "modifier": "EXACT"}, "end": {"value": 329, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023053"}], "id": "KW-0915", "category": "Ligand", "name": "Sodium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022461"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0894", "category": "Molecular function", "name": "Sodium channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023201"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0739", "category": "Biological process", "name": "Sodium transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000679"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34072.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154998", "properties": [{"key": "ProteinId", "value": "WRW34072.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005272", "properties": [{"key": "GoTerm", "value": "F:sodium channel activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR001873", "properties": [{"key": "EntryName", "value": "ENaC"}]}, {"database": "Pfam", "id": "PF00858", "properties": [{"key": "EntryName", "value": "ASC"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MNRKSNLNLSSALADEKKRISRRQATLENLLNNQKMTSFNKILTIRNFSWLITWLCCFAGCFYQSIEVVKSFLKSETTTSMEYSTTSDLPALTICFDKSELINTKNETIRNTINQLDISQQLNFTYNYPELFISCTVVTIQDSIPCEEFLTITHFVTFDYKCISLHELKYEVYSSKIKSKLLLNHTHIYSFTLNRTVVGRQFDLTIHNLTNPLQILDQNWVKLSPFRYSAAKISFHHIQMSLLPSPYDTNCSSYEEDITKANCLNKCFVEEYYWKESKWPPYVPGFNKKKKTLTNKIYIETNTTAKPEIPKRKKRQVSSISSTETNLNKTLKPKRKPSVNSKLLSILKSVNKTKKKGLGYNFLTEKLFYEKIKFQFKDEYELNTKTMSEAKLSIKGIPDIRGYCDYRCDRGQECHEDIYKPIKEVEIEANTEDLETYVVEIKPSKYVLRCLTIEKYKRVHLACFLASTITLWFGGSIFFLVSYLIKGNLHTLRCLFCYKKVNQD", "length": 504, "molWeight": 58882, "crc64": "2743115880A54CB8", "md5": "0F324A7815BEA392FDAD4EF2579D601E"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI003250636B"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTS3", "uniProtkbId": "A0AAT9UTS3_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41635.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41635.1"}], "value": "Cytochrome P450 6QA1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41635.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117195", "properties": [{"key": "ProteinId", "value": "WIM41635.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002402", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-II"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00464", "properties": [{"key": "EntryName", "value": "EP450II"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MILYVAVLIIVLLLYYYSRYPSNPWKKLGIPYADPVPILGNISDFIFGRKHISLVYDDVYKDRSFVENAFVGIMEIRSPNLIVRDVRLANRILVKDFAYFHDRGMDVDEDLDPLNAHLVNLSGSRWKTTRSKLMPAFSSGKLKQMYALIEDCVKELDTCLDRVSMEGGITDVREVMAQFSTDVIGRCAFGLDFNTMKDPQSAFRSIGKKIFVLSWSIVARICLRLINPRLLKWIRIKAVSNEVETFFFNLLYDTIRYRKTEVNERYDFLQIMCNIKAQEEQQHVPKDERLSDTLLVANMFVFFAGGFETTATTLSYCLYELALNEDVQQRARTEIITLMKSRNGVLDYDSLNELNYLEMIIMGKLPLFLALTELTFARFFVSCFRNITKVSTDTTG", "length": 396, "molWeight": 45757, "crc64": "95D76326A0340CDE", "md5": "92E0B18524244B471B53B6541AF139C5"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "uniParcId": "UPI0035D3D07B"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38YAT3", "uniProtkbId": "A0AB38YAT3_9ANNE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Ophryotrocha xiamen", "taxonId": 2741705, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WKC16023.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Errantia", "Eunicida", "Dorvilleidae", "Ophryotrocha"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WKC16023.1"}], "value": "Fibrillin"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 1894, "modifier": "EXACT"}, "end": {"value": 1917, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 58, "modifier": "EXACT"}, "end": {"value": 232, "modifier": "EXACT"}}, "description": "VWFD", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51233"}]}, {"type": "Repeat", "location": {"start": {"value": 296, "modifier": "EXACT"}, "end": {"value": 402, "modifier": "EXACT"}}, "description": "Filamin", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00087"}]}, {"type": "Domain", "location": {"start": {"value": 495, "modifier": "EXACT"}, "end": {"value": 542, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 634, "modifier": "EXACT"}, "end": {"value": 680, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 724, "modifier": "EXACT"}, "end": {"value": 767, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 768, "modifier": "EXACT"}, "end": {"value": 807, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 809, "modifier": "EXACT"}, "end": {"value": 845, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 847, "modifier": "EXACT"}, "end": {"value": 883, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 884, "modifier": "EXACT"}, "end": {"value": 919, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 921, "modifier": "EXACT"}, "end": {"value": 962, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1003, "modifier": "EXACT"}, "end": {"value": 1042, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1047, "modifier": "EXACT"}, "end": {"value": 1087, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1089, "modifier": "EXACT"}, "end": {"value": 1126, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1128, "modifier": "EXACT"}, "end": {"value": 1163, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1165, "modifier": "EXACT"}, "end": {"value": 1200, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1202, "modifier": "EXACT"}, "end": {"value": 1239, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1240, "modifier": "EXACT"}, "end": {"value": 1276, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1368, "modifier": "EXACT"}, "end": {"value": 1414, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1415, "modifier": "EXACT"}, "end": {"value": 1450, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1452, "modifier": "EXACT"}, "end": {"value": 1488, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1490, "modifier": "EXACT"}, "end": {"value": 1525, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1527, "modifier": "EXACT"}, "end": {"value": 1564, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1566, "modifier": "EXACT"}, "end": {"value": 1609, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Domain", "location": {"start": {"value": 1618, "modifier": "EXACT"}, "end": {"value": 1736, "modifier": "EXACT"}}, "description": "SEA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50024"}]}, {"type": "Domain", "location": {"start": {"value": 1733, "modifier": "EXACT"}, "end": {"value": 1772, "modifier": "EXACT"}}, "description": "EGF-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50026"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 734, "modifier": "EXACT"}, "end": {"value": 751, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 797, "modifier": "EXACT"}, "end": {"value": 806, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 835, "modifier": "EXACT"}, "end": {"value": 844, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 873, "modifier": "EXACT"}, "end": {"value": 882, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 888, "modifier": "EXACT"}, "end": {"value": 898, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 909, "modifier": "EXACT"}, "end": {"value": 918, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1077, "modifier": "EXACT"}, "end": {"value": 1086, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1116, "modifier": "EXACT"}, "end": {"value": 1125, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1132, "modifier": "EXACT"}, "end": {"value": 1142, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1153, "modifier": "EXACT"}, "end": {"value": 1162, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1169, "modifier": "EXACT"}, "end": {"value": 1179, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1190, "modifier": "EXACT"}, "end": {"value": 1199, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1229, "modifier": "EXACT"}, "end": {"value": 1238, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1266, "modifier": "EXACT"}, "end": {"value": 1275, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1419, "modifier": "EXACT"}, "end": {"value": 1429, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1440, "modifier": "EXACT"}, "end": {"value": 1449, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1478, "modifier": "EXACT"}, "end": {"value": 1487, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1494, "modifier": "EXACT"}, "end": {"value": 1504, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1515, "modifier": "EXACT"}, "end": {"value": 1524, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1554, "modifier": "EXACT"}, "end": {"value": 1563, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1599, "modifier": "EXACT"}, "end": {"value": 1608, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1762, "modifier": "EXACT"}, "end": {"value": 1771, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}]}, {"type": "Sequence uncertainty", "location": {"start": {"value": 1804, "modifier": "EXACT"}, "end": {"value": 1804, "modifier": "EXACT"}}, "description": "D or N", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WKC16023.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022536"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00076"}], "id": "KW-0245", "category": "Domain", "name": "EGF-like domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-92V6O8DTO1K0F", "citationType": "submission", "authors": ["Chen R."], "publicationDate": "JUL-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WKC16023.1"}], "value": "F3-7", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WKC16023.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR256800", "properties": [{"key": "ProteinId", "value": "WKC16023.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0005509", "properties": [{"key": "GoTerm", "value": "F:calcium ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00054", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "16"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000066", "properties": [{"key": "EntryName", "value": "FAT atypical cadherin 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000014", "properties": [{"key": "EntryName", "value": "Latent-transforming growth factor beta-binding protein 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000279", "properties": [{"key": "EntryName", "value": "Neurogenic locus notch 1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000173", "properties": [{"key": "EntryName", "value": "Neurogenic locus notch protein 2"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000143", "properties": [{"key": "EntryName", "value": "Protein crumbs 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.10.25.10:FF:000321", "properties": [{"key": "EntryName", "value": "Protein delta homolog 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.10.25.10", "properties": [{"key": "EntryName", "value": "Laminin"}, {"key": "MatchStatus", "value": "25"}]}, {"database": "InterPro", "id": "IPR026823", "properties": [{"key": "EntryName", "value": "cEGF"}]}, {"database": "InterPro", "id": "IPR001881", "properties": [{"key": "EntryName", "value": "EGF-like_Ca-bd_dom"}]}, {"database": "InterPro", "id": "IPR013032", "properties": [{"key": "EntryName", "value": "EGF-like_CS"}]}, {"database": "InterPro", "id": "IPR000742", "properties": [{"key": "EntryName", "value": "EGF-like_dom"}]}, {"database": "InterPro", "id": "IPR000152", "properties": [{"key": "EntryName", "value": "EGF-type_Asp/Asn_hydroxyl_site"}]}, {"database": "InterPro", "id": "IPR018097", "properties": [{"key": "EntryName", "value": "EGF_Ca-bd_CS"}]}, {"database": "InterPro", "id": "IPR017868", "properties": [{"key": "EntryName", "value": "Filamin/ABP280_repeat-like"}]}, {"database": "InterPro", "id": "IPR009030", "properties": [{"key": "EntryName", "value": "Growth_fac_rcpt_cys_sf"}]}, {"database": "InterPro", "id": "IPR049883", "properties": [{"key": "EntryName", "value": "NOTCH1_EGF-like"}]}, {"database": "InterPro", "id": "IPR000082", "properties": [{"key": "EntryName", "value": "SEA_dom"}]}, {"database": "InterPro", "id": "IPR001846", "properties": [{"key": "EntryName", "value": "VWF_type-D"}]}, {"database": "PANTHER", "id": "PTHR12916", "properties": [{"key": "EntryName", "value": "CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12916:SF4", "properties": [{"key": "EntryName", "value": "UNINFLATABLE, ISOFORM C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF12662", "properties": [{"key": "EntryName", "value": "cEGF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00008", "properties": [{"key": "EntryName", "value": "EGF"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "Pfam", "id": "PF07645", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "Pfam", "id": "PF12661", "properties": [{"key": "EntryName", "value": "hEGF"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "Pfam", "id": "PF01390", "properties": [{"key": "EntryName", "value": "SEA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00010", "properties": [{"key": "EntryName", "value": "EGFBLOOD"}]}, {"database": "SMART", "id": "SM00181", "properties": [{"key": "EntryName", "value": "EGF"}, {"key": "MatchStatus", "value": "30"}]}, {"database": "SMART", "id": "SM00179", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "23"}]}, {"database": "SMART", "id": "SM00216", "properties": [{"key": "EntryName", "value": "VWD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57196", "properties": [{"key": "EntryName", "value": "EGF/Laminin"}, {"key": "MatchStatus", "value": "9"}]}, {"database": "SUPFAM", "id": "SSF57184", "properties": [{"key": "EntryName", "value": "Growth factor receptor domain"}, {"key": "MatchStatus", "value": "7"}]}, {"database": "PROSITE", "id": "PS00010", "properties": [{"key": "EntryName", "value": "ASX_HYDROXYL"}, {"key": "MatchStatus", "value": "15"}]}, {"database": "PROSITE", "id": "PS00022", "properties": [{"key": "EntryName", "value": "EGF_1"}, {"key": "MatchStatus", "value": "17"}]}, {"database": "PROSITE", "id": "PS01186", "properties": [{"key": "EntryName", "value": "EGF_2"}, {"key": "MatchStatus", "value": "15"}]}, {"database": "PROSITE", "id": "PS50026", "properties": [{"key": "EntryName", "value": "EGF_3"}, {"key": "MatchStatus", "value": "22"}]}, {"database": "PROSITE", "id": "PS01187", "properties": [{"key": "EntryName", "value": "EGF_CA"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS50194", "properties": [{"key": "EntryName", "value": "FILAMIN_REPEAT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50024", "properties": [{"key": "EntryName", "value": "SEA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51233", "properties": [{"key": "EntryName", "value": "VWFD"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTARWFQFLMGHPFNEPDVHYWEDVKPRQWCCDDSKYSCHYYRTARPHQGCTEYFPPFWSWFFGDPHITTSDGKIYTFNGLGDYVFLKSDIINIHIRAEQVTVDLIIKTYPNHPTVSDLTQWYNDAEVNDALIFDGGALSLNKNNGTLGVRFSDYELELTCSVGPVGDLSVSVGVTQMLIDIPTYGLLGNINGDPDDDFILPDGTHLPTDSNEQSIYENFGLRWLVNLPGNPASLFEYADGESAATYEAPDDYEPQYAGFDQLTDEELAQIQSVCGDNYPCQYDMALTNNQEMGEASGSSSSESEEVSSGLANKVPSFVLDVTNIQVTVGEEYSFDVTVNDTDDDDFTFNVTLPERAVFTVDDNDDKMGTFTWTPDSTDEVELSFGGKDSHDVQAVPAPIDILLCDCNENGVCDFNNQLPNQTTDESFRIVQCNCTLGWIGDHCETDRNGCADSPCSEVQECYDLSPEEEQQFQRGFNCSECPDGYNDLNSICVDIDECSPEAPATSPCTIVEGAQAEATCVNSVGSYTCTCPQGYELDADDTNMCVDINECTTSRHNCAQLCNNTPLGSFTCACNTGYDLDEDGFTCTSNGQDDCANLVPPKNCAGYCLNGDDPSCACPDDKVLAADGFSCTDVNECTTEVESKQHQCGDHTECHNEEPGYSCTCTAGYTLNDDGRTCSPCPTGNWGVDCTNVCSCLTPSDCDIVIGCTECPEGWNGTNCDQDINECAEENKCGPADHGTCENSDGSFACVCSNGYIYNTEAEICEFDDYCTHPNVQRCLNGGTCEHATASFTCVCAEGYEGDTCETDIDDCVEHECEGEATCSDQVGGYTCICPRGKSGQYCNQDFDECSSNPCMNNGVCNNEDSMFTCDCTNEWTGVTCLEVNDCADEPCVHGECVDGDDMYTCECERGWGGTNCDTDLDECALQTSGCDHTCENTPAGNFTCSCLTDYTLADDGTTCDLDPNATPCDPVCDSDRGICSAGQCSCPAGWRKEDDSTTCVDFDECANDDDNLCGDGATCQNSDGGYSCTCEDGYLLQSDEVTCLLDDYCTHNTPAVKCYNGGTCTGVVGGFECECTDGFLGDVCNEEVNECMPTNPCQNEGTCSDLRGGFSCRCAAGWSGETCTIEYDECESNPCVNGDCDDQLGAYQCNCNDGYTGQQCEAEIDECAPEPCVNGACRDLFNAYECDCDAGWEGDDCDQDIDECDADPCQNGGTCTTPEINSYSCECTDAFTGDNCDAQNYCNGDPCQNGGECTSGATTYSCECTAGWSGDDCTTDLDECTLGTDNCQHECENTQGSFTCSCYTGYDIQEDGFSCVSDGSVTCDPACDFAQGICVQVENSNPPATQCACVSGYTITDNGGTQSCTDINECTTQDAEHQHACVAPATCTNSEPGYTCECPAGQELQSDGINCMDIDECEPEPCEHGTCTNGDNMFTCDCDDGYTGTTCDTNIDDCTPDPCNGVGECTDRVNGYICNCNDGYDGDQCETNVDECASSPCMNGDCVDGVNQFTCDCYRGFIGSSCETDIDECAEYTPCANGATCTQGEGRYTCTCPDGYTGRNCSDVATACDADPHPCNDNGECTVAEGDNPDPAYTCACIPTYEGDNCDQEVSTESIPTTTVVASFSMSVAFVPALSDTTSQEYITLATSLRASLMRIFVGSAIRRAIMRIDNIRFRAGSTVADYDIVLAEEEATDIDTDDLNQVVVDAIEADPYGEIVEGYPVDTSTVTSQDLDECTRSPCAAQRGVCFSLDISPGYTCDCDELYDGTNCESRVNIPSKSFEIQLKFELATDTLEREWIXDXDAGNDVDPELDDSIYTQMKASAGDDFVGITDINYSYGSIVATFTLVVSKDSDLTEESLKASLEGMDLPDGVTLNLDSTTIEEKESSNTNTLIGVILGAVLGVFFLILAISFCLWKSKRRIPRDR", "length": 1927, "molWeight": 208072, "crc64": "09CD043B35D33FBC", "md5": "B40A1B49B77771F74F3CE0DD404BB012"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "CAUTION": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 24, "Repeat": 1, "Disulfide bond": 22, "Sequence uncertainty": 1}, "uniParcId": "UPI00388C2FC9"}, "cluster_size": 1, "family": "Dorvilleidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN34", "uniProtkbId": "A0AA96MN34_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50040.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50040.1"}], "value": "Filaggrin isoform X13-like protein"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 60, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50040.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460117", "properties": [{"key": "ProteinId", "value": "WNS50040.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "3.30.720.110", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.720.120", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR029068", "properties": [{"key": "EntryName", "value": "Glyas_Bleomycin-R_OHBP_Dase"}]}, {"database": "InterPro", "id": "IPR004360", "properties": [{"key": "EntryName", "value": "Glyas_Fos-R_dOase_dom"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "Pfam", "id": "PF00903", "properties": [{"key": "EntryName", "value": "Glyoxalase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54593", "properties": [{"key": "EntryName", "value": "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSCRHTGVVPYLMSPDCQKHIEWLTKVFDAKQEAIYFTDDTKTVVMHASISINDGVLYICDYNCMPEQKDAKDSSHPGAVKGSMFQIEVANQAAADQLWKKILDNEGKVTMELKAQFWEGYYGTAVDPFGYEWAICSSLDKKDEQPKALI", "length": 150, "molWeight": 16952, "crc64": "0A0865F70363DC2E", "md5": "277572C6E20B6AA2ABA2CE94213B6519"}, "extraAttributes": {"countByFeatureType": {"Domain": 1}, "uniParcId": "UPI002B2E4E47"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB33JQP8", "uniProtkbId": "A0AB33JQP8_9MUSC", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Sarcophaga similis", "taxonId": 305538, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFP29892.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Diptera", "Brachycera", "Muscomorpha", "Oestroidea", "Sarcophagidae", "Sarcophaga", "Pandelleisca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFP29892.1"}], "value": "Short neuropeptide F"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFP29892.1"}], "value": "sNPF"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFP29892.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 185, "modifier": "EXACT"}, "end": {"value": 185, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFP29892.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFP29892.1"}], "id": "KW-0527", "category": "Molecular function", "name": "Neuropeptide"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-6G2K09UV50L21", "citationType": "submission", "authors": ["Goto S.", "Yoshinaga N."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFP29892.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-D6T7TA4EMALVC", "citationType": "submission", "authors": ["Goto S.G.", "Yoshinaga N."], "title": "Expression of genes involved in ecdysteroidogenesis in relation to pupal diapause entry in the flesh fly Sarcophaga similis.", "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BFP29892.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC832170", "properties": [{"key": "ProteinId", "value": "BFP29892.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0007218", "properties": [{"key": "GoTerm", "value": "P:neuropeptide signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "YAGPVVFPNQRVVRKAQRSPSLRLRFGRRADPEIDQMPQTAEKRWFGDVNQKPIRSPSLRLRFGRRSDPSMPIHSAYDIMMNEQQLAETNDNDYNDAYDGYYERVVRKPQRLRFGRSLPFQAINSVNENQLSNDIMDNEEDFDLANNEDDFYNTLMHSQKVRSLLMALQKNNDDDMREEGEEFER", "length": 185, "molWeight": 21855, "crc64": "D835965A27F46986", "md5": "64206E89EAC349474C77A99F74F93A07"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI00388C15B5"}, "cluster_size": 1, "family": "Sarcophagidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZES2", "uniProtkbId": "A0AB38ZES2_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02795.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02795.1"}], "value": "Venom peptide Os5a"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02795.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517545", "properties": [{"key": "ProteinId", "value": "WXI02795.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MDPNPFFRLFPLLFFFFFIQMQAIIKSSSLENMAILVKNTEKKKTTLHLQKLENVLALYGTNTVFV", "length": 66, "molWeight": 7728, "crc64": "EBE561426ACDD112", "md5": "BBA77F295578721A2CB1DFA6F045DBEB"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI00388C21D5"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAD9KRN5", "uniProtkbId": "A0AAD9KRN5_RIDPI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ridgeia piscesae", "commonName": "Tubeworm", "taxonId": 27915, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176075.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001209878"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Sedentaria", "Canalipalpata", "Sabellida", "Siboglinidae", "Ridgeia"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}], "value": "Ig-like domain-containing protein"}}}, "genes": [{"orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176075.1"}], "value": "NP493_688g01019"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176075.1"}], "value": "The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 1014, "modifier": "EXACT"}}, "description": "Ig-like domain-containing protein", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042222356"}, {"type": "Domain", "location": {"start": {"value": 247, "modifier": "EXACT"}, "end": {"value": 320, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047216"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001209878"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "37494294", "citationType": "journal article", "authors": ["Perez M.", "Aroh O.", "Sun Y.", "Lan Y.", "Juniper S.K.", "Young C.R.", "Angers B.", "Qian P.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37494294"}, {"database": "DOI", "id": "10.1093/molbev/msad172"}], "title": "Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.", "publicationDate": "2023", "journal": "Mol. Biol. Evol.", "firstPage": "msad172", "lastPage": "msad172", "volume": "40"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176075.1"}], "value": "R07B-5", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2176075.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "JAODUO010000686", "properties": [{"key": "ProteinId", "value": "KAK2176075.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP001209878", "properties": [{"key": "Component", "value": "Unassembled WGS sequence"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008061", "properties": [{"key": "GoTerm", "value": "F:chitin binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "2.60.40.1120", "properties": [{"key": "EntryName", "value": "Carboxypeptidase-like, regulatory domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.20.100.10", "properties": [{"key": "EntryName", "value": "Thrombospondin type-1 (TSP1) repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008969", "properties": [{"key": "EntryName", "value": "CarboxyPept-like_regulatory"}]}, {"database": "InterPro", "id": "IPR002557", "properties": [{"key": "EntryName", "value": "Chitin-bd_dom"}]}, {"database": "InterPro", "id": "IPR056255", "properties": [{"key": "EntryName", "value": "CILP-1/2_dom"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR000884", "properties": [{"key": "EntryName", "value": "TSP1_rpt"}]}, {"database": "InterPro", "id": "IPR036383", "properties": [{"key": "EntryName", "value": "TSP1_rpt_sf"}]}, {"database": "Pfam", "id": "PF13620", "properties": [{"key": "EntryName", "value": "CarboxypepD_reg"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01607", "properties": [{"key": "EntryName", "value": "CBM_14"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23708", "properties": [{"key": "EntryName", "value": "CILP_5th"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13927", "properties": [{"key": "EntryName", "value": "Ig_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00209", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49464", "properties": [{"key": "EntryName", "value": "Carboxypeptidase regulatory domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF82895", "properties": [{"key": "EntryName", "value": "TSP-1 type 1 repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50092", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MACEVAAMTRLRCVFVTAFVVAGVLVSVESKCKSTGRSCVRSCVKRLNGNYQSCNGCHVYVTCSSHVMYDNRPCPARLVWNDKTKVCDWMSPTCTCKATCDGGTQRRVRRCDDPSPQNGGSDCVGVSSESRPCNQWACPGNMSSHLSTRGRFIADCSQCLCAGDSVSGKVTDRQTSLALANVNIYTVGREWSPSAVSGSDGRFTISGVCVDGLKLTARKGGYESASREYSVSADSSVTVVMYTLERPTLTVEPASTAGFVGGKASFSCRATAEPDVSQYDWFKDGDLLRSDKVSVGGNSGATYNVNGLTTGDEGVYACRAVSLGGKIFSRGANLIVKDAGAIDTCDEKPQDQWVELPPTCSVTNGGIRVKSVNIGRCHQVPCVTKTSLDSANLCCVPSSTRQMEVECHGFSYKVNQIVTCGCSECKSDNTVTVSGIVKSGDASVLVPTTGLQITQDTVQYRVINSQFSFEAMPRAGKILFHVKSSIFMAQLVTLDISEGVTAMYVEVTLVPKPSPDIVDVATGGQVNVDTPGLPSAVSINIAPSSFQDTNGNPVLGRVKIYTTFADPRKSDGIANAPGQFTFEDSEGVTRHLKTFGVITLMAEDTTGNDVFLSGKASIEIDADALGVETGESVALWSIDGSSGAWRKSETLTYTGSRRRRRQVAISGNSVAGETEIPPNLPYLNCDRPFLRGRLCSIAVFVYYGGDFSIPLEGERVSAFIKENGLFIGRTSGFSDQNGKACLLVVCGLQHIVRLESVNGVTVHPTHHLPFGFAVTNTVDGFEFTATSPATQVDNVNGPVFKYRAWRSICSSSNSSTYHFSLAKPPVRPSLYGSLNAVEMRPGFDLSWFPNPPAGREVCVVQVGIKTYEPSEIKMVGISTAVNGDQYGTHTSTSMKRSYSRNELYRVACVVFRCPTNESEYTAVDLQIVSNKGSQCRFTYSVLVNVVGDYHGVTKYVSHSNSSFQVRILARAEGEKRGFDVGIYRATNPGDVAFYRAINKCTTGFTRVADFDCSG", "length": 1014, "molWeight": 109053, "crc64": "2D6663CE845257D0", "md5": "0D2B34F61BC7040780310800AC1B3D7C"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00288597A3"}, "cluster_size": 4, "family": "Siboglinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAD9UF28", "uniProtkbId": "A0AAD9UF28_RIDPI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ridgeia piscesae", "commonName": "Tubeworm", "taxonId": 27915, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2186950.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001209878"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Polychaeta", "Sedentaria", "Canalipalpata", "Sabellida", "Siboglinidae", "Ridgeia"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}], "value": "Ig-like domain-containing protein"}}}, "genes": [{"orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2186950.1"}], "value": "NP493_184g03040"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2186950.1"}], "value": "The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}], "commentType": "CAUTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 67, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 276, "modifier": "EXACT"}, "end": {"value": 351, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Region", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 58, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 543, "modifier": "EXACT"}, "end": {"value": 575, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 38, "modifier": "EXACT"}, "end": {"value": 50, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047216"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001209878"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "37494294", "citationType": "journal article", "authors": ["Perez M.", "Aroh O.", "Sun Y.", "Lan Y.", "Juniper S.K.", "Young C.R.", "Angers B.", "Qian P.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37494294"}, {"database": "DOI", "id": "10.1093/molbev/msad172"}], "title": "Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.", "publicationDate": "2023", "journal": "Mol. Biol. Evol.", "firstPage": "msad172", "lastPage": "msad172", "volume": "40"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2186950.1"}], "value": "R07B-5", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK2186950.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "JAODUO010000183", "properties": [{"key": "ProteinId", "value": "KAK2186950.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP001209878", "properties": [{"key": "Component", "value": "Unassembled WGS sequence"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "FunFam", "id": "2.20.100.10:FF:000002", "properties": [{"key": "EntryName", "value": "Unc-5 netrin receptor C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.1120", "properties": [{"key": "EntryName", "value": "Carboxypeptidase-like, regulatory domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.20.100.10", "properties": [{"key": "EntryName", "value": "Thrombospondin type-1 (TSP1) repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008969", "properties": [{"key": "EntryName", "value": "CarboxyPept-like_regulatory"}]}, {"database": "InterPro", "id": "IPR056255", "properties": [{"key": "EntryName", "value": "CILP-1/2_dom"}]}, {"database": "InterPro", "id": "IPR039675", "properties": [{"key": "EntryName", "value": "CILP1/CILP2"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003599", "properties": [{"key": "EntryName", "value": "Ig_sub"}]}, {"database": "InterPro", "id": "IPR003598", "properties": [{"key": "EntryName", "value": "Ig_sub2"}]}, {"database": "InterPro", "id": "IPR000884", "properties": [{"key": "EntryName", "value": "TSP1_rpt"}]}, {"database": "InterPro", "id": "IPR036383", "properties": [{"key": "EntryName", "value": "TSP1_rpt_sf"}]}, {"database": "PANTHER", "id": "PTHR15031:SF6", "properties": [{"key": "EntryName", "value": "CARTILAGE INTERMEDIATE LAYER PROTEIN 1-LIKE ISOFORM X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR15031", "properties": [{"key": "EntryName", "value": "CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23708", "properties": [{"key": "EntryName", "value": "CILP_5th"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13927", "properties": [{"key": "EntryName", "value": "Ig_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00090", "properties": [{"key": "EntryName", "value": "TSP_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR01705", "properties": [{"key": "EntryName", "value": "TSP1REPEAT"}]}, {"database": "SMART", "id": "SM00409", "properties": [{"key": "EntryName", "value": "IG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00408", "properties": [{"key": "EntryName", "value": "IGc2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00209", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49464", "properties": [{"key": "EntryName", "value": "Carboxypeptidase regulatory domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF82895", "properties": [{"key": "EntryName", "value": "TSP-1 type 1 repeat"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50092", "properties": [{"key": "EntryName", "value": "TSP1"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEWTWSTEKPVKRVFPTLYTWADMFGPRLHRFPGRPTAFQTPDMSDGSETTIDDDKGRPRVSESKRLFLHVIGVVVIISAVIGVVLAIVFGLPPKDKEETRPAGSSTLPVDGQWSDWDPWSSCSKTCGKGTKWRTRKCSDPEPLNGGRNCIGKSTERDDCATWKCPDCSKSCPGGGRLSADCSVCECNSNGPIRGRVVYVYNTTTLPLDDVHVYVVGREWSPHATTDRTGRFSITGLCRKSTKLIFLHDDYLTDKAQYQVSSTGDVNVDMIKKVSPKFLSEPQDATVFVGDTVTFHCHATGVPLPDKYEWFKDGSILEDKMGKTLQIKSASSENIGLYRCRASSKFAKKFSKIAYLQVKENAVDTCDVTPTPFDVTLPPGCNVTLDGAVLTNVNVRECPPEPCVSRSEKTAGRCCGPIETSDVKVLCERYNFTMKRVVRCGCAECEKDGDVDVTGRVGVRRTVDGKSRVILVNASLVVSGNDVDPEDCNTTGGFFSFSATPDAGRITVRFYQDDNTDFLPQVIVIEVSRGVSSVTRDVVLQAKPKPQPLDPNKGGAFKASSTSPTVKIPPNSIVDADGNPYNGTVNVFPTFADPLDMESIAEAPGEFSFENEEGESQALQTNGVIGLSFESDTGAPLQLSGKTTLTLDPDALGIGKTADGQPDSYVWTLDAETGKWKMAAPLTYAKRRRKRNVATNSVTVSLVIPYPLPYINLDKPALRRVRCTLIIQVYADLAFTQPLSDISLQVVTKSPNGIFLGYTMGYTNDKGRACVTIMCGYQHFIVLKPVLGEPRPHRTHHLPRGTVYKNLAHRVMFTSPSVDDILDDRGPVIRDTNWQGWWKCYSGDESQYHFKFAVPIIYFPGFLIPEVQKPRHRLSWYLQPLNTATRRACMVQVRIEASDLHRV", "length": 903, "molWeight": 99755, "crc64": "566C5987930A1083", "md5": "744D6B193D8BEC56F48A2130E359428D"}, "extraAttributes": {"countByCommentType": {"CAUTION": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1, "Region": 2, "Compositional bias": 1}, "uniParcId": "UPI0028861C31"}, "cluster_size": 1, "family": "Siboglinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PAV2", "uniProtkbId": "A0AAU6PAV2_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20553.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20553.1"}], "value": "Venom peptide"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 3, "modifier": "EXACT"}, "end": {"value": 138, "modifier": "EXACT"}}, "description": "SCP", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00198"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20553.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 149, "modifier": "EXACT"}, "end": {"value": 149, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20553.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20553.1"}], "value": "U_LCTX_61_Cm21", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20553.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480822", "properties": [{"key": "ProteinId", "value": "WXB20553.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "CDD", "id": "cd05380", "properties": [{"key": "EntryName", "value": "CAP_euk"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.33.10", "properties": [{"key": "EntryName", "value": "CAP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR018244", "properties": [{"key": "EntryName", "value": "Allrgn_V5/Tpx1_CS"}]}, {"database": "InterPro", "id": "IPR014044", "properties": [{"key": "EntryName", "value": "CAP_dom"}]}, {"database": "InterPro", "id": "IPR035940", "properties": [{"key": "EntryName", "value": "CAP_sf"}]}, {"database": "InterPro", "id": "IPR001283", "properties": [{"key": "EntryName", "value": "CRISP-related"}]}, {"database": "InterPro", "id": "IPR002413", "properties": [{"key": "EntryName", "value": "V5_allergen-like"}]}, {"database": "PANTHER", "id": "PTHR10334", "properties": [{"key": "EntryName", "value": "CYSTEINE-RICH SECRETORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00188", "properties": [{"key": "EntryName", "value": "CAP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00838", "properties": [{"key": "EntryName", "value": "V5ALLERGEN"}]}, {"database": "PRINTS", "id": "PR00837", "properties": [{"key": "EntryName", "value": "V5TPXLIKE"}]}, {"database": "SMART", "id": "SM00198", "properties": [{"key": "EntryName", "value": "SCP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55797", "properties": [{"key": "EntryName", "value": "PR-1-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01009", "properties": [{"key": "EntryName", "value": "CRISP_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01010", "properties": [{"key": "EntryName", "value": "CRISP_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VSGQPAATDMKYMVWDEELAKKAADWASHNNFAHNPDRKIGSGRFSTGENLYIFSTSGKANEINVDKALKAWFDEKKDYTYKQLKGSDFGAGPQTGHYTQMVWAKTTHVGCAISQFMKDSWQNFLFVCNYGPAGNFLNEYPYSTKGKKK", "length": 149, "molWeight": 16800, "crc64": "732BD5A2F7CC57EF", "md5": "CAB97C7AD14A2FA30C51DC771A362D40"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D3997E"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEA1", "uniProtkbId": "A0AB38ZEA1_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71751.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71751.1"}], "value": "Venom S1 protease 29"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00024195"}], "value": "Belongs to the peptidase S1 family. CLIP subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 219, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50240"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71751.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU363034"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71751.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510826", "properties": [{"key": "ProteinId", "value": "WXH71751.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00190", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001314", "properties": [{"key": "EntryName", "value": "Peptidase_S1A"}]}, {"database": "InterPro", "id": "IPR051487", "properties": [{"key": "EntryName", "value": "Ser/Thr_Proteases_Immune/Dev"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR018114", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}]}, {"database": "InterPro", "id": "IPR033116", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}]}, {"database": "PANTHER", "id": "PTHR24256", "properties": [{"key": "EntryName", "value": "TRYPTASE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00722", "properties": [{"key": "EntryName", "value": "CHYMOTRYPSIN"}]}, {"database": "SMART", "id": "SM00020", "properties": [{"key": "EntryName", "value": "Tryp_SPc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50240", "properties": [{"key": "EntryName", "value": "TRYPSIN_DOM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00134", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00135", "properties": [{"key": "EntryName", "value": "TRYPSIN_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVALKAYFGEAHIDCGGSIITHRHVLTAAHCLLNMFVDMSAVKPEDLYVIVGAHDLEKLTPKESVKQYQALKHFIRQEFIKQYTHDIAIVVVKDEIEFTPTVGPICLSPKKIAELNKIITIIGWGKTETGKTSKTLLKAKTAIIDRKRCDCNLNELCTRADKSATCTGDSGGPLSWLDPETNRYTLMSLVSYGDPDCVSTPSVSTDVFFFYDWIQDTIKATFPEEMTCVKKE", "length": 232, "molWeight": 25928, "crc64": "900EC6E50C0E37DC", "md5": "5110DF57F26068D91D247038247D0F74"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI00388C28F5"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEB4", "uniProtkbId": "A0AB38ZEB4_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Ectomocoris sp", "taxonId": 3104572, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71766.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Peiratinae", "Ectomocoris"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71766.1"}], "value": "Venom S1 protease with CUB domain 7"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 132, "modifier": "EXACT"}, "end": {"value": 186, "modifier": "EXACT"}}, "description": "Peptidase S1", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00089"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 194, "modifier": "EXACT"}, "end": {"value": 194, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71766.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71766.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71766.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-14PRNTM40BSC1", "citationType": "submission", "authors": ["Jin J.A.", "King G.A.", "Walker A."], "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXH71766.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP510841", "properties": [{"key": "ProteinId", "value": "WXH71766.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR035914", "properties": [{"key": "EntryName", "value": "Sperma_CUB_dom_sf"}]}, {"database": "InterPro", "id": "IPR001254", "properties": [{"key": "EntryName", "value": "Trypsin_dom"}]}, {"database": "InterPro", "id": "IPR018114", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}]}, {"database": "PANTHER", "id": "PTHR24252", "properties": [{"key": "EntryName", "value": "ACROSIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24252:SF7", "properties": [{"key": "EntryName", "value": "HYALIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00089", "properties": [{"key": "EntryName", "value": "Trypsin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49854", "properties": [{"key": "EntryName", "value": "Spermadhesin, CUB domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00134", "properties": [{"key": "EntryName", "value": "TRYPSIN_HIS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTKYLEKRWIFRTEPGIRLSLTCLDFRFPDSNPCSQGMEVDNGETSKIYCGSQNGLIIFSHDQEIKVKLFTGFYGGGGGAKCMIQAINGPSHLQYENEVSEEIDSSEHGVQPGRVGTTCQCGWTNKKVGRIAHGHETGINEYPWMVAIRESLKPGASPPPLHFCGGSIITHYHILSAAHCVYDRMDEELYAVVG", "length": 194, "molWeight": 21484, "crc64": "3363870083CBD4F0", "md5": "E0597CD173A292AD68FE47FA07FFBD09"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388C06D3"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZLL4", "uniProtkbId": "A0AB38ZLL4_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Arma chinensis", "taxonId": 763200, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAI73915.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Pentatomomorpha", "Pentatomoidea", "Pentatomidae", "Asopinae", "Arma"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAI73915.1"}], "value": "Toll7"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004479"}], "value": "Single-pass type I membrane protein", "id": "SL-9905"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009634"}], "value": "Belongs to the Toll-like receptor family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 519, "modifier": "EXACT"}, "end": {"value": 543, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 576, "modifier": "EXACT"}, "end": {"value": 721, "modifier": "EXACT"}}, "description": "TIR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50104"}]}, {"type": "Region", "location": {"start": {"value": 766, "modifier": "EXACT"}, "end": {"value": 835, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 768, "modifier": "EXACT"}, "end": {"value": 794, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 842, "modifier": "EXACT"}, "end": {"value": 842, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAI73915.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022614"}], "id": "KW-0433", "category": "Domain", "name": "Leucine-rich repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BUCAHSIHLB966", "citationType": "submission", "authors": ["Yuan X.", "Fu Y."], "title": "miR-8 maintains the immune homeostasis of Arma chinensis Fallou by inhibiting AcMNPV's essential genes and regulating the innate immune response in host insect.", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XAI73915.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP263631", "properties": [{"key": "ProteinId", "value": "XAI73915.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004888", "properties": [{"key": "GoTerm", "value": "F:transmembrane signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006955", "properties": [{"key": "GoTerm", "value": "P:immune response"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0002224", "properties": [{"key": "GoTerm", "value": "P:toll-like receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.80.10.10", "properties": [{"key": "EntryName", "value": "Ribonuclease Inhibitor"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "3.40.50.10140", "properties": [{"key": "EntryName", "value": "Toll/interleukin-1 receptor homology (TIR) domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001611", "properties": [{"key": "EntryName", "value": "Leu-rich_rpt"}]}, {"database": "InterPro", "id": "IPR003591", "properties": [{"key": "EntryName", "value": "Leu-rich_rpt_typical-subtyp"}]}, {"database": "InterPro", "id": "IPR032675", "properties": [{"key": "EntryName", "value": "LRR_dom_sf"}]}, {"database": "InterPro", "id": "IPR000372", "properties": [{"key": "EntryName", "value": "LRRNT"}]}, {"database": "InterPro", "id": "IPR000157", "properties": [{"key": "EntryName", "value": "TIR_dom"}]}, {"database": "InterPro", "id": "IPR017241", "properties": [{"key": "EntryName", "value": "Toll-like_receptor"}]}, {"database": "InterPro", "id": "IPR035897", "properties": [{"key": "EntryName", "value": "Toll_tir_struct_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24365:SF541", "properties": [{"key": "EntryName", "value": "PROTEIN TOLL-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24365", "properties": [{"key": "EntryName", "value": "TOLL-LIKE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13855", "properties": [{"key": "EntryName", "value": "LRR_8"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Pfam", "id": "PF01582", "properties": [{"key": "EntryName", "value": "TIR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF037595", "properties": [{"key": "EntryName", "value": "Toll-like_receptor"}, {"key": "MatchStatus", "value": "5"}]}, {"database": "SMART", "id": "SM00369", "properties": [{"key": "EntryName", "value": "LRR_TYP"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "SMART", "id": "SM00013", "properties": [{"key": "EntryName", "value": "LRRNT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00255", "properties": [{"key": "EntryName", "value": "TIR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52058", "properties": [{"key": "EntryName", "value": "L domain-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF52200", "properties": [{"key": "EntryName", "value": "Toll/Interleukin receptor TIR domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51450", "properties": [{"key": "EntryName", "value": "LRR"}, {"key": "MatchStatus", "value": "4"}]}, {"database": "PROSITE", "id": "PS50104", "properties": [{"key": "EntryName", "value": "TIR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNQLTGLRLIDNNIGNLTRGMFWDLTGLQVLNLAKNKIQQIERGTFERNVEIEAIRLDANFLTDINGVFTTLASLVWLNLSDNHLVWFDYAFIPSNLKWLDIHNNFIQRLGNYYKIQEELHIKTLDASHNRIEEINDLSIPNSIEVMFINNNLITTIHHNTFFEKNHLARVDIYANELSKLELNALRLSPIPQNKSAPEFYLGGNPFLCDCSMDWLPEINNISQSQRQYPKVMDLDNVMCRMTYSRGTVHILAPEAKSSEFLCKYETHCFALCQCCDFDACDCEMICPQNCSCYHDQTWNTNVVDCSRRRSDLIPRRIPMDATHVYLDGNNLKELQNHVFIGRKNMMVLYVNASRVETIQNRTFNGLNALQTLHLEDNLISELKGYEFEHLAQLKELYLQNNLIAHIGNMTLLPLRSLEILRLEGNRLVTFPVWQLTLNTYLVDITLGNNLWSCKCKFLTELQTWVADNKQKVSDTDDLWCYGNDTKPPHRRLIDLNNTVCSDFFAGSSMIQNIIVSDYLPMVIVTLSAFLIVIFLTVMMFIFRDPIRVWLYSRYGVRLFHFKASSAKHYGEDREKLYDGYVVYSPKDEEFVLQSIVAELEHGTPAFQLCLHYRDLPHHAVSNSPYLQHATSPVVVEAAEASKRVILVLSRNFLQTEWSRFEFRSALHEALKGRIFKLVLVEEGSIIPEAELDPDLRPYLKTGARIRWGEKRFWERLRYVMPSGDNQRKSCNYRRNINNYSLDSGVHRSPSHPHPCQQDKKLFKPEQTGYSSSSTLSRTQQEDPNYSSATTATPSPRPSHRHYSNDRPTSEHIYSSIDSPEYPPFRQNGQPWREPAVQAYLV", "length": 842, "molWeight": 97578, "crc64": "E9B134BA29269E41", "md5": "905B501E89C4C596A8142A41DE0F15B3"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1, "Region": 1, "Compositional bias": 1, "Non-terminal residue": 1}, "uniParcId": "UPI00388BCCA6"}, "cluster_size": 1, "family": "Pentatomidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0Z2", "uniProtkbId": "A0AA96S0Z2_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50087.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50087.1"}], "value": "Forkhead box protein L2-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00089"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 83, "modifier": "EXACT"}, "end": {"value": 178, "modifier": "EXACT"}}, "description": "Fork-head", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50039"}]}, {"type": "DNA binding", "location": {"start": {"value": 83, "modifier": "EXACT"}, "end": {"value": 178, "modifier": "EXACT"}}, "description": "Fork-head", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00089"}]}, {"type": "Region", "location": {"start": {"value": 301, "modifier": "EXACT"}, "end": {"value": 323, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 303, "modifier": "EXACT"}, "end": {"value": 323, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00089"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00089"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50087.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460164", "properties": [{"key": "ProteinId", "value": "WNS50087.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0009653", "properties": [{"key": "GoTerm", "value": "P:anatomical structure morphogenesis"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030154", "properties": [{"key": "GoTerm", "value": "P:cell differentiation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "1.10.10.10:FF:000598", "properties": [{"key": "EntryName", "value": "forkhead box protein I1 isoform X2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.10.10", "properties": [{"key": "EntryName", "value": "Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001766", "properties": [{"key": "EntryName", "value": "Fork_head_dom"}]}, {"database": "InterPro", "id": "IPR050211", "properties": [{"key": "EntryName", "value": "FOX_domain-containing"}]}, {"database": "InterPro", "id": "IPR018122", "properties": [{"key": "EntryName", "value": "TF_fork_head_CS_1"}]}, {"database": "InterPro", "id": "IPR030456", "properties": [{"key": "EntryName", "value": "TF_fork_head_CS_2"}]}, {"database": "InterPro", "id": "IPR036388", "properties": [{"key": "EntryName", "value": "WH-like_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR036390", "properties": [{"key": "EntryName", "value": "WH_DNA-bd_sf"}]}, {"database": "PANTHER", "id": "PTHR11829:SF343", "properties": [{"key": "EntryName", "value": "FORK-HEAD DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11829", "properties": [{"key": "EntryName", "value": "FORKHEAD BOX PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00250", "properties": [{"key": "EntryName", "value": "Forkhead"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00053", "properties": [{"key": "EntryName", "value": "FORKHEAD"}]}, {"database": "SMART", "id": "SM00339", "properties": [{"key": "EntryName", "value": "FH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF46785", "properties": [{"key": "EntryName", "value": "Winged helix' DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00657", "properties": [{"key": "EntryName", "value": "FORK_HEAD_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00658", "properties": [{"key": "EntryName", "value": "FORK_HEAD_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50039", "properties": [{"key": "EntryName", "value": "FORK_HEAD_3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MMPVAIAVVPQVSVASPVEGSDSSSEVYNHPNSVSEVNEEEFRLAMQRSMSMNNRKVPPEPVPTIPARMIKLDATTKRESLTKPPYSYVALISMAIENDQRKRLTLNGIYDFITDKFPYYAQRENQGWKNSIRHNLSLHECFTKLPEKGGKNGKSHFWTLDPSNEVIFEEGNYRRRRRRPVKKPSTPYPAIYGSYPYPSQQLRQDMIHGRHGGWESHPMLPGYPIQTPSNILPGQLQVQQGIHATPFAFSSPHAFPPDNSHRVSAAAMFGAYAGPYQTHNLALTPGLRATSALDQKPGVPMHPSSQGYMPSAVYQQQPGSNVL", "length": 323, "molWeight": 36154, "crc64": "B50E95F45E3DD4D9", "md5": "2C47E8917DD4F6848E1642B86C39C422"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "DNA binding": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B2FFA65"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAA9WUW4", "uniProtkbId": "A0AAA9WUW4_MOUSE", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159939.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159939.1"}], "value": "TSR3 20S rRNA accumulation"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159939.1"}, {"evidenceCode": "ECO:0000313", "source": "MGI", "id": "MGI:1915577"}], "value": "Tsr3"}}], "features": [{"type": "Domain", "location": {"start": {"value": 60, "modifier": "EXACT"}, "end": {"value": 92, "modifier": "EXACT"}}, "description": "RNase L inhibitor RLI-like possible metal-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF04068"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAA9WUW4"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAA9WUW4"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "19468303", "citationType": "journal article", "authoringGroup": ["Mouse Genome Sequencing Consortium"], "authors": ["Church D.M.", "Goodstadt L.", "Hillier L.W.", "Zody M.C.", "Goldstein S.", "She X.", "Bult C.J.", "Agarwala R.", "Cherry J.L.", "DiCuccio M.", "Hlavina W.", "Kapustin Y.", "Meric P.", "Maglott D.", "Birtle Z.", "Marques A.C.", "Graves T.", "Zhou S.", "Teague B.", "Potamousis K.", "Churas C.", "Place M.", "Herschleb J.", "Runnheim R.", "Forrest D.", "Amos-Landgraf J.", "Schwartz D.C.", "Cheng Z.", "Lindblad-Toh K.", "Eichler E.E.", "Ponting C.P."], "citationCrossReferences": [{"database": "PubMed", "id": "19468303"}, {"database": "DOI", "id": "10.1371/journal.pbio.1000112"}], "title": "Lineage-specific biology revealed by a finished genome assembly of the mouse.", "publicationDate": "2009", "journal": "PLoS Biol.", "firstPage": "e1000112", "lastPage": "e1000112", "volume": "7"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159939.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159939.1"}]}, {"referenceNumber": 2, "citation": {"id": "21750661", "citationType": "journal article", "authors": ["Church D.M.", "Schneider V.A.", "Graves T.", "Auger K.", "Cunningham F.", "Bouk N.", "Chen H.C.", "Agarwala R.", "McLaren W.M.", "Ritchie G.R.", "Albracht D.", "Kremitzki M.", "Rock S.", "Kotkiewicz H.", "Kremitzki C.", "Wollam A.", "Trani L.", "Fulton L.", "Fulton R.", "Matthews L.", "Whitehead S.", "Chow W.", "Torrance J.", "Dunn M.", "Harden G.", "Threadgold G.", "Wood J.", "Collins J.", "Heath P.", "Griffiths G.", "Pelan S.", "Grafham D.", "Eichler E.E.", "Weinstock G.", "Mardis E.R.", "Wilson R.K.", "Howe K.", "Flicek P.", "Hubbard T."], "citationCrossReferences": [{"database": "PubMed", "id": "21750661"}], "title": "Modernizing reference genome assemblies.", "publicationDate": "2011", "journal": "PLoS Biol.", "firstPage": "e1001091", "lastPage": "e1001091", "volume": "9"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159939.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159939.1"}]}, {"referenceNumber": 3, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159939.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159939.1"}]}], "uniProtKBCrossReferences": [{"database": "Ensembl", "id": "ENSMUST00000249835.1", "properties": [{"key": "ProteinId", "value": "ENSMUSP00000159939.1"}, {"key": "GeneId", "value": "ENSMUSG00000015126.11"}]}, {"database": "AGR", "id": "MGI:1915577", "properties": [{"key": "Description", "value": "-"}]}, {"database": "MGI", "id": "MGI:1915577", "properties": [{"key": "GeneName", "value": "Tsr3"}]}, {"database": "GeneTree", "id": "ENSGT00390000014665", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000000589", "properties": [{"key": "Component", "value": "Chromosome 17"}]}, {"database": "GO", "id": "GO:0106388", "properties": [{"key": "GoTerm", "value": "F:rRNA small subunit aminocarboxypropyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006364", "properties": [{"key": "GoTerm", "value": "P:rRNA processing"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR007209", "properties": [{"key": "EntryName", "value": "RNaseL-inhib-like_metal-bd_dom"}]}, {"database": "InterPro", "id": "IPR022968", "properties": [{"key": "EntryName", "value": "Tsr3-like"}]}, {"database": "PANTHER", "id": "PTHR20426:SF0", "properties": [{"key": "EntryName", "value": "18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR20426", "properties": [{"key": "EntryName", "value": "RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF04068", "properties": [{"key": "EntryName", "value": "Fer4_RLI"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGRKKVARGSRKESGRVRRPSGRSLDAFAEEVGAALRASVQPEEAEDQGGPGPAALPCALAMWELGHCDPKRCTGRKLARLGLVRCLRLSQRFGGLVLSPVGTEYVSPADSEASLQGCALFGALEPTLHSLTDSWWHSQGSQS", "length": 143, "molWeight": 15242, "crc64": "97C48075F8C2200D", "md5": "DB9A33616322399FA498F74D934851E1"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1}, "uniParcId": "UPI002B504EAB"}, "cluster_size": 2, "family": "Muridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QL55", "uniProtkbId": "A0AAU0QL55_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56484.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56484.1"}], "value": "Odorant receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56484.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56484.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56484.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970377", "properties": [{"key": "ProteinId", "value": "WPO56484.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MTLAQLIQLSITYEIVGSESEKLSNDVYYVPWESMSISNQRSTCILLQRVQSPIHVTAMGMTDVGVQTMAAILKTTFSYFTLLQSLNDE", "length": 89, "molWeight": 9981, "crc64": "E28293AB06208833", "md5": "BD9CDDE1AF8E29F3460D8EDF8AF3D621"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "uniParcId": "UPI0030855E6B"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEQ9", "uniProtkbId": "A0AB38ZEQ9_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02779.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02779.1"}], "value": "Venom Ptu1 family peptide Os2a"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 57, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044192541"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02779.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517529", "properties": [{"key": "ProteinId", "value": "WXI02779.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MKLLIFLLIAVICTTVVSAGRCITTGNECGGNDLKCCGRSVCSFNVRDRRSYCVFAP", "length": 57, "molWeight": 6176, "crc64": "CF57CB1BC229FA90", "md5": "584D29CA087F8384E45D59B555ACAF8E"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BF45B"}, "cluster_size": 2, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTL5", "uniProtkbId": "A0AAT9UTL5_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41697.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41697.1"}], "value": "Cytochrome P450 4445C2"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Binding site", "location": {"start": {"value": 460, "modifier": "EXACT"}, "end": {"value": 460, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41697.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117257", "properties": [{"key": "ProteinId", "value": "WIM41697.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000042", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYFNFNTIGLIGVVIALFWYYGRSTFNYWKKLNVNYKEPVAFFGNVGDFAMFKSSFHDTLKSLYEHFPDEPFGGFFQMRTPVLLLKDPSIVYSVLIKDFKSFVNRGFELAYPNKDLNPFSGHLFLSEGDRWRVLRNKMSPVFTSGKLKYMYEQIFHCVEVLNKFIENDLKNDSIDVDVKELFERFTIDVIGTCAFGLECNSLKDSNAEFQAMGVKIFKPTIFNAVRVIFTAFSTKLLVIFKIPDVQKDITDFFLNVISSSVTYRRQNKIVRNDFLQLLMELQNTSRNRKYDVDVQKNDVLKGEEFDEIDVAANAFLFFAAGFETTASTLGFCLYELAINQDVQEKLRQEVQTVKTQCGGKLTAECLKDFYYMDMVLAETLRKYPPLPVLHRESVEDYVIPDTKIKLPAGTKIQIPIHSIHHDWKYYPNPEKFDPERFTHENKVNRLNGTYIPFGDGPRYCIGKRFAFMEMKAALADVMTKYNFSPCSKTQIPLSFKHGSLLMSPKNGIWLNISKIN", "length": 516, "molWeight": 59760, "crc64": "460AABCA16A5BFF6", "md5": "AEB2DD58E1D464AAB0C49B37AD197B34"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Binding site": 1}, "uniParcId": "UPI0035D39144"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6SHA5", "uniProtkbId": "A0AAU6SHA5_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32417.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32417.1"}], "value": "Cytochrome P450 3638E1"}}], "flag": "Fragment"}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 13, "modifier": "EXACT"}, "end": {"value": 34, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Coiled coil", "location": {"start": {"value": 259, "modifier": "EXACT"}, "end": {"value": 286, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 384, "modifier": "EXACT"}, "end": {"value": 384, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32417.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FURNHM9O37J9N", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjun Reddy K.", "Ramasamy G.G."], "title": "Partial mRNA sequence of CYP3638E1 from Maconellicoccus hirsutus (Green).", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WZP32417.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR247760", "properties": [{"key": "ProteinId", "value": "WZP32417.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "METPLKVLLNRCWSSNFSTILIILFGVLWMYYLYKCRMRGLTKKLESFNSIPTVPLIGNLNILSGTKKERAIKWYKLVTEHETPLVFWLLHKPIFILGRSQDIQVVLNRTLERDLLGMFEMVFGDSITGLQGEKWRKHRRIVTSAFSPNMLQEYLKIFNKYSFLLTNDLKKFADNDIAINTWKHVNHTNSLSITQNMTGHKLERGDRSITEFTDAFNKSLEIETSRFTCPVLLPKLIYKLYLLISGKIEIFKTMHRFPRQIVKERLQEYEKKLQENEQRKETDNSKTLIDSLLNSHIADAEFTEKHVRAEIASMIILGNDSTSTITNFVLLMMAMYPNIQERVYEEIKTVLGNSDREVEIEDIRKFVYLERCIKETLRKFTFLP", "length": 384, "molWeight": 45168, "crc64": "B75C05F5FF566E91", "md5": "81DE508C21C8EAC47E84FC2C9DA40FFC"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Coiled coil": 1, "Non-terminal residue": 1}, "uniParcId": "UPI0035D35823"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BGV7", "uniProtkbId": "A0AAQ5BGV7_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519068.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519068.1"}], "value": "Desmoglein 2"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519068.1"}], "value": "DSG2"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 104, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042824585"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BGV7"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BGV7"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519068.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519068.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16177791", "citationType": "journal article", "authors": ["Nusbaum C.", "Zody M.C.", "Borowsky M.L.", "Kamal M.", "Kodira C.D.", "Taylor T.D.", "Whittaker C.A.", "Chang J.L.", "Cuomo C.A.", "Dewar K.", "FitzGerald M.G.", "Yang X.", "Abouelleil A.", "Allen N.R.", "Anderson S.", "Bloom T.", "Bugalter B.", "Butler J.", "Cook A.", "DeCaprio D.", "Engels R.", "Garber M.", "Gnirke A.", "Hafez N.", "Hall J.L.", "Norman C.H.", "Itoh T.", "Jaffe D.B.", "Kuroki Y.", "Lehoczky J.", "Lui A.", "Macdonald P.", "Mauceli E.", "Mikkelsen T.S.", "Naylor J.W.", "Nicol R.", "Nguyen C.", "Noguchi H.", "O'Leary S.B.", "O'Neill K.", "Piqani B.", "Smith C.L.", "Talamas J.A.", "Topham K.", "Totoki Y.", "Toyoda A.", "Wain H.M.", "Young S.K.", "Zeng Q.", "Zimmer A.R.", "Fujiyama A.", "Hattori M.", "Birren B.W.", "Sakaki Y.", "Lander E.S."], "citationCrossReferences": [{"database": "PubMed", "id": "16177791"}, {"database": "DOI", "id": "10.1038/nature03983"}], "title": "DNA sequence and analysis of human chromosome 18.", "publicationDate": "2005", "journal": "Nature", "firstPage": "551", "lastPage": "555", "volume": "437"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519068.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519068.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC021549", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AC079096", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000713767.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519068.1"}, {"key": "GeneId", "value": "ENSG00000046604.15"}]}, {"database": "HGNC", "id": "HGNC:3049", "properties": [{"key": "GeneName", "value": "DSG2"}]}, {"database": "OpenTargets", "id": "ENSG00000046604", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT01030000234624", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 18"}]}], "sequence": {"value": "MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKKKEDSKLLTNTLEKGLQSHLLVYLSLTKILEN", "length": 104, "molWeight": 11703, "crc64": "4190F895873F079F", "md5": "3EDD7522626C8A7655A2E508042F5AD2"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0032CEE00A"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39TZ30", "uniProtkbId": "A0AB39TZ30_MOUSE", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84326.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00040486"}], "value": "IgG receptor FcRn large subunit p51"}}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00041407"}], "value": "IgG Fc fragment receptor transporter alpha chain"}}, {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00041280"}], "value": "Neonatal Fc receptor"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "MGI", "id": "MGI:103017"}], "value": "Fcgrt"}, "synonyms": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84326.1"}], "value": "FCGRT"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00046029"}], "value": "Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB"}], "commentType": "FUNCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00046902"}], "value": "FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer. Interacts with albumin/ALB; this interaction regulates ALB homeostasis"}], "commentType": "SUBUNIT"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004251"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004251"}], "value": "Single-pass type I membrane protein", "id": "SL-9905"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004177"}], "value": "Endosome", "id": "SL-0101"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008637"}], "value": "Belongs to the immunoglobulin superfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 148, "modifier": "EXACT"}}, "description": "IgG receptor FcRn large subunit p51", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044340174"}, {"type": "Domain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "Ig-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50835"}]}, {"type": "Region", "location": {"start": {"value": 121, "modifier": "EXACT"}, "end": {"value": 148, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 121, "modifier": "EXACT"}, "end": {"value": 134, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022753"}], "id": "KW-0967", "category": "Cellular component", "name": "Endosome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023319"}], "id": "KW-0393", "category": "Domain", "name": "Immunoglobulin domain"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84326.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "38607033", "citationType": "journal article", "authors": ["Haddad G.", "Blaine J."], "citationCrossReferences": [{"database": "PubMed", "id": "38607033"}], "title": "Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.", "publicationDate": "2024", "journal": "Cells", "firstPage": "0", "lastPage": "0", "volume": "13"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84326.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-FV12BRJLLL9E9", "citationType": "submission", "authors": ["Haddad G.", "Blaine J."], "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDQ84326.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ136842", "properties": [{"key": "ProteinId", "value": "XDQ84326.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "AGR", "id": "MGI:103017", "properties": [{"key": "Description", "value": "-"}]}, {"database": "MGI", "id": "MGI:103017", "properties": [{"key": "GeneName", "value": "Fcgrt"}]}, {"database": "GO", "id": "GO:0005768", "properties": [{"key": "GoTerm", "value": "C:endosome"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "FunFam", "id": "2.60.40.10:FF:000693", "properties": [{"key": "EntryName", "value": "IgG receptor FcRn large subunit p51"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR007110", "properties": [{"key": "EntryName", "value": "Ig-like_dom"}]}, {"database": "InterPro", "id": "IPR036179", "properties": [{"key": "EntryName", "value": "Ig-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR003006", "properties": [{"key": "EntryName", "value": "Ig/MHC_CS"}]}, {"database": "InterPro", "id": "IPR003597", "properties": [{"key": "EntryName", "value": "Ig_C1-set"}]}, {"database": "InterPro", "id": "IPR050208", "properties": [{"key": "EntryName", "value": "MHC_class-I_related"}]}, {"database": "PANTHER", "id": "PTHR16675:SF3", "properties": [{"key": "EntryName", "value": "IGG RECEPTOR FCRN LARGE SUBUNIT P51"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR16675", "properties": [{"key": "EntryName", "value": "MHC CLASS I-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07654", "properties": [{"key": "EntryName", "value": "C1-set"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00407", "properties": [{"key": "EntryName", "value": "IGc1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF48726", "properties": [{"key": "EntryName", "value": "Immunoglobulin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50835", "properties": [{"key": "EntryName", "value": "IG_LIKE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00290", "properties": [{"key": "EntryName", "value": "IG_MHC"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGMPLPWALSLLLVLLPQTWGSEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLAPWLSLSGDDSGDLLPGGNLPPEAEPQGANAFPATS", "length": 148, "molWeight": 15699, "crc64": "5A23AFCB252E5EB2", "md5": "CC20A515954880819E33D39123CFC2AA"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "SUBUNIT": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI00388C0761"}, "cluster_size": 1, "family": "Muridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S0F7", "uniProtkbId": "A0AA96S0F7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50090.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50090.1"}], "value": "Ras-related protein Rap-2a"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 192, "modifier": "EXACT"}, "end": {"value": 229, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 218, "modifier": "EXACT"}, "end": {"value": 229, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023134"}], "id": "KW-0342", "category": "Ligand", "name": "GTP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50090.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460167", "properties": [{"key": "ProteinId", "value": "WNS50090.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005525", "properties": [{"key": "GoTerm", "value": "F:GTP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003924", "properties": [{"key": "GoTerm", "value": "F:GTPase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR005225", "properties": [{"key": "EntryName", "value": "Small_GTP-bd"}]}, {"database": "InterPro", "id": "IPR001806", "properties": [{"key": "EntryName", "value": "Small_GTPase"}]}, {"database": "InterPro", "id": "IPR020849", "properties": [{"key": "EntryName", "value": "Small_GTPase_Ras-type"}]}, {"database": "NCBIfam", "id": "TIGR00231", "properties": [{"key": "EntryName", "value": "small_GTP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24070", "properties": [{"key": "EntryName", "value": "RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00071", "properties": [{"key": "EntryName", "value": "Ras"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00449", "properties": [{"key": "EntryName", "value": "RASTRNSFRMNG"}]}, {"database": "SMART", "id": "SM00175", "properties": [{"key": "EntryName", "value": "RAB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00173", "properties": [{"key": "EntryName", "value": "RAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00174", "properties": [{"key": "EntryName", "value": "RHO"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51419", "properties": [{"key": "EntryName", "value": "RAB"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51421", "properties": [{"key": "EntryName", "value": "RAS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGTGGVGKSALTLRIISGTFTPNYTPTIEDYYRHETNVPSIGPCIVEPDSGQRGTEQFSSMRQLYISSSQAFAIVYAVDDRDSFEEAKGIYKEIVQSKPEGQARVILVGNKSDLYDAHRRVPIAEALQLCKTMANAPFLETSAKDNINVHELFTKLVHLARDNVESSSKTLKPRRRTFNNGFTNAIRKSFRMSRQRRRVNSAHFSDGAGAHGNSQRPSARRRQSRCAVM", "length": 229, "molWeight": 25586, "crc64": "7B571638965702D5", "md5": "9E39A29B89A2530FA0994A51CBFA5D92"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B2D4B26"}, "cluster_size": 2, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLU2", "uniProtkbId": "A0AAU0QLU2_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56509.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56509.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 41, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 87, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 124, "modifier": "EXACT"}, "end": {"value": 149, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 166, "modifier": "EXACT"}, "end": {"value": 166, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56509.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56509.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56509.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56509.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970402", "properties": [{"key": "ProteinId", "value": "WPO56509.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "MSEYYHKKLKQNLVNEFDFLGHLGTKIFIYPFVGKSKIVTALFRLVFFFLIFTAVQLMITLYVKDFGDWVELVNVIPNLAVVIMAAIKYNKFYVNCSVYQKYFHHYRNHIWEIVTNSQAHKEIIAIYTTILCLVNRFLFYYSIILLIFVNSFPRVFMFLEEMFTDD", "length": 166, "molWeight": 19879, "crc64": "1E02420F12606385", "md5": "B5965EA4B2B5538469D24BE481A6A7F1"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 3, "Non-terminal residue": 1}, "uniParcId": "UPI003088BB34"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VEV3", "uniProtkbId": "A0AAU7VEV3_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67482.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67482.1"}], "value": "Boule2"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67482.1"}], "value": "boule2"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 32, "modifier": "EXACT"}, "end": {"value": 110, "modifier": "EXACT"}}, "description": "RRM", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50102"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 11, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022782"}], "id": "KW-0221", "category": "Biological process", "name": "Differentiation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00176"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022871"}], "id": "KW-0744", "category": "Biological process", "name": "Spermatogenesis"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022845"}], "id": "KW-0810", "category": "Biological process", "name": "Translation regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67482.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67482.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750687", "properties": [{"key": "ProteinId", "value": "XBW67482.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003730", "properties": [{"key": "GoTerm", "value": "F:mRNA 3'-UTR binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0008494", "properties": [{"key": "GoTerm", "value": "F:translation activator activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0070935", "properties": [{"key": "GoTerm", "value": "P:3'-UTR-mediated mRNA stabilization"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030154", "properties": [{"key": "GoTerm", "value": "P:cell differentiation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0051321", "properties": [{"key": "GoTerm", "value": "P:meiotic cell cycle"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0045948", "properties": [{"key": "GoTerm", "value": "P:positive regulation of translational initiation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007283", "properties": [{"key": "GoTerm", "value": "P:spermatogenesis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd12412", "properties": [{"key": "EntryName", "value": "RRM_DAZL_BOULE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.70.330:FF:000167", "properties": [{"key": "EntryName", "value": "protein boule-like isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.70.330", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR034988", "properties": [{"key": "EntryName", "value": "DAZ_BOULE_RRM"}]}, {"database": "InterPro", "id": "IPR012677", "properties": [{"key": "EntryName", "value": "Nucleotide-bd_a/b_plait_sf"}]}, {"database": "InterPro", "id": "IPR035979", "properties": [{"key": "EntryName", "value": "RBD_domain_sf"}]}, {"database": "InterPro", "id": "IPR000504", "properties": [{"key": "EntryName", "value": "RRM_dom"}]}, {"database": "PANTHER", "id": "PTHR11176", "properties": [{"key": "EntryName", "value": "BOULE-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11176:SF57", "properties": [{"key": "EntryName", "value": "PROTEIN BOULE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00076", "properties": [{"key": "EntryName", "value": "RRM_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00360", "properties": [{"key": "EntryName", "value": "RRM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54928", "properties": [{"key": "EntryName", "value": "RNA-binding domain, RBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50102", "properties": [{"key": "EntryName", "value": "RRM"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAAADGTSSSGQKEDGPMLTNQAPKYGMLIPSRVFVGGIANNTTESDLRQFFTTYGPIRDCKIIQDRAGVSKGYGFVTFESVDDAEKLMKKEGDHVLFKDRKLNIGPAIRKQQAAARMYDQTAAANAAMLYSAAGLPYAIHPSQLALLQGHAAELNASNQSAQLIVCGRKTNINS", "length": 175, "molWeight": 18799, "crc64": "8FB882E1E8814D36", "md5": "B01F1BB18176EE758231013893F7F77C"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0035D38FE5"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QPB6", "uniProtkbId": "A0AAU0QPB6_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56556.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56556.1"}], "value": "Odorant binding protein/PBP-general odorant binding protein"}}], "flag": "Fragment"}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008098"}], "value": "Belongs to the PBP/GOBP family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56556.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56556.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56556.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970295", "properties": [{"key": "ProteinId", "value": "WPO56556.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006072", "properties": [{"key": "EntryName", "value": "Odorant/phero-bd_Lep"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "PRINTS", "id": "PR00484", "properties": [{"key": "EntryName", "value": "PBPGOBP"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MHHENTEKFIKSFPNGEILAQHLVKFIHECEKQHDAEEDHCVRILRIAECFRDTCRRRDLAPTMEMLLAEFIMQAER", "length": 77, "molWeight": 9238, "crc64": "D94EFBA29B98DFC2", "md5": "57E76A21E2C6C71FFA82404BF15C2747"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0030876B9D"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38Z7I6", "uniProtkbId": "A0AB38Z7I6_PAESU", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia suffruticosa", "commonName": "Tree peony", "synonyms": ["Paeonia moutan"], "taxonId": 45171, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20353.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20353.1"}], "value": "Bifunctional 3-dehydroquinate dehydratase shikimate dehydrogenase"}}]}, "references": [{"referenceNumber": 1, "citation": {"id": "CI-67NUCHPS7RPVN", "citationType": "submission", "authors": ["Zhang Y.", "Gai S."], "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20353.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR237938", "properties": [{"key": "ProteinId", "value": "WRI20353.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004764", "properties": [{"key": "GoTerm", "value": "F:shikimate 3-dehydrogenase (NADP+) activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0009423", "properties": [{"key": "GoTerm", "value": "P:chorismate biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0019632", "properties": [{"key": "GoTerm", "value": "P:shikimate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "3.40.50.720", "properties": [{"key": "EntryName", "value": "NAD(P)-binding Rossmann-like Domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR036291", "properties": [{"key": "EntryName", "value": "NAD(P)-bd_dom_sf"}]}, {"database": "InterPro", "id": "IPR022893", "properties": [{"key": "EntryName", "value": "Shikimate_DH_fam"}]}, {"database": "PANTHER", "id": "PTHR21089:SF12", "properties": [{"key": "EntryName", "value": "BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21089", "properties": [{"key": "EntryName", "value": "SHIKIMATE DEHYDROGENASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF51735", "properties": [{"key": "EntryName", "value": "NAD(P)-binding Rossmann-fold domains"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MENMIWGANNGYLTMKTTIVVKLKESTSYFGDVSSHAHTLRAWAEKQVDHGVVCVSGQELNIILNTNASPFYKLTKMKHLCSLLTAKTEKLTTKFRGQAITLDEYDIFYLEDGMILANTTSAGIKPKSGLTPYLRLKKPWKFLLKSLSHYSVVFYAIYTPKWTKLLTEAYESGATIIFWTGMFINQAFVQF", "length": 191, "molWeight": 21715, "crc64": "B031AA310D4C4B46", "md5": "9064B359179F4459555F6AF6A6D47648"}, "extraAttributes": {"uniParcId": "UPI00388BCCAE"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MN25", "uniProtkbId": "A0AA96MN25_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50025.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50025.1"}], "value": "Adhesion G protein-coupled receptor L3-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007343"}], "value": "Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 377, "modifier": "EXACT"}, "end": {"value": 400, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 412, "modifier": "EXACT"}, "end": {"value": 430, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 450, "modifier": "EXACT"}, "end": {"value": 470, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 482, "modifier": "EXACT"}, "end": {"value": 503, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 528, "modifier": "EXACT"}, "end": {"value": 555, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 576, "modifier": "EXACT"}, "end": {"value": 601, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 607, "modifier": "EXACT"}, "end": {"value": 629, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Region", "location": {"start": {"value": 127, "modifier": "EXACT"}, "end": {"value": 146, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 679, "modifier": "EXACT"}, "end": {"value": 715, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 761, "modifier": "EXACT"}, "end": {"value": 812, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 679, "modifier": "EXACT"}, "end": {"value": 693, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 770, "modifier": "EXACT"}, "end": {"value": 781, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 782, "modifier": "EXACT"}, "end": {"value": 794, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 797, "modifier": "EXACT"}, "end": {"value": 812, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50025.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50025.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460102", "properties": [{"key": "ProteinId", "value": "WNS50025.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd15040", "properties": [{"key": "EntryName", "value": "7tmB2_Adhesion"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.20.1070.10:FF:000058", "properties": [{"key": "EntryName", "value": "Adhesion G protein-coupled receptor F5"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.220.50", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR046338", "properties": [{"key": "EntryName", "value": "GAIN_dom_sf"}]}, {"database": "InterPro", "id": "IPR000832", "properties": [{"key": "EntryName", "value": "GPCR_2_secretin-like"}]}, {"database": "InterPro", "id": "IPR000203", "properties": [{"key": "EntryName", "value": "GPS"}]}, {"database": "PANTHER", "id": "PTHR12011", "properties": [{"key": "EntryName", "value": "ADHESION G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12011:SF347", "properties": [{"key": "EntryName", "value": "FI21270P1-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00002", "properties": [{"key": "EntryName", "value": "7tm_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01825", "properties": [{"key": "EntryName", "value": "GPS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00249", "properties": [{"key": "EntryName", "value": "GPCRSECRETIN"}]}, {"database": "SMART", "id": "SM00303", "properties": [{"key": "EntryName", "value": "GPS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEVNRALNGTKDSNLPVTVEEREVAVSVVEMLSTALRDSAQTNNSILPGDLDIATEVVSDFARLSENNELFNTVNVAEKTKIVKSVANVFSDVLDSTNNAAFGSSTEQSPAVSLLDSAEQLARSGFTSLSDVNSSTPTNDSQGQQGELVQRNIAIQTNRLSTSLLIETNFTFPKLSEESLNAFKNSDLVPLVKIPGDFVQALIQDTSPAATTSSPSTINAPPSFTASSVNEVNVVSFTLNNIQNHLSGELIEQEDDKKRRSSELASLVVSSQITEAKRTGIDSVDGPKVQLSFPLLSDVYDKVESTLAADERMEVRCAAWNFTGGPEGKGGWSFAGIEVVSYNRTAIECTSSHLTSFCVLVSVVPPKKTITDKVFSVITYIGCSISLVCLLLSIVFFLSLRKELIKRLHNFVHLNLCIALSLGLIVYIAGVEHAKTIQGACVFVSVLLHYFFLAAFSWMLCEAVMIYILLVKVFGANERKWIYMYLGLGWGIPVPIVVVSVAIRHKEYFIRDATETIFACWLPTKGGVIAAFIGPMLAILLINAVLLTLSLVSLAKSKCGRSKEVKMEDKESLQTAWQLTKATLILLPLMGFTWIIGLLAVGPGQDAVAIVFILLNTLQGVFIFILHVVRHEKVWSKIKSRLPSIRSEKSTLGSGHSSATKSTLQRSTLKRSIFGKFSTTSSQNTSTLKSQSEGVFKPLDNGDGESIKGSSDDNHEEIEMKEGTNGTNGHTSEEPVVVVTASSFGHSDVVVGTTGFSVGDATTDLPINGEQDQPFSEQTQDPSHKDYDSMHDVNADNGDSPTLPMTSSFGIH", "length": 812, "molWeight": 87958, "crc64": "41B604D92F246F12", "md5": "BACE09E4A35878FFD76F5B3E6B0A8028"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Region": 3, "Compositional bias": 4}, "uniParcId": "UPI002B28D357"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9XZI3", "uniProtkbId": "A0AAT9XZI3_PINTA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pinus taeda", "commonName": "Loblolly pine", "taxonId": 3352, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Pinopsida", "Pinidae", "Conifers I", "Pinales", "Pinaceae", "Pinus", "Pinus subgen. Pinus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}], "value": "Endoribonuclease dicer-like protein 2"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}], "value": "DCL2"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001946"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}]}, {"commentType": "COFACTOR", "cofactors": [{"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001936"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 179, "modifier": "EXACT"}, "end": {"value": 296, "modifier": "EXACT"}}, "description": "PAZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50821"}]}, {"type": "Domain", "location": {"start": {"value": 313, "modifier": "EXACT"}, "end": {"value": 493, "modifier": "EXACT"}}, "description": "RNase III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50142"}]}, {"type": "Domain", "location": {"start": {"value": 534, "modifier": "EXACT"}, "end": {"value": 681, "modifier": "EXACT"}}, "description": "RNase III", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50142"}]}, {"type": "Domain", "location": {"start": {"value": 707, "modifier": "EXACT"}, "end": {"value": 775, "modifier": "EXACT"}}, "description": "DRBM", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50137"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022759"}], "id": "KW-0255", "category": "Molecular function", "name": "Endonuclease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022842"}], "id": "KW-0460", "category": "Ligand", "name": "Magnesium"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023211"}], "id": "KW-0464", "category": "Ligand", "name": "Manganese"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022722"}], "id": "KW-0540", "category": "Molecular function", "name": "Nuclease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00266"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-134CKBQBAMOI5", "citationType": "submission", "authors": ["Bragg Z.", "Rieske L.K."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}], "value": "7-56xOP_8", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}], "value": "Whole plant", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-CRD440VTN3173", "citationType": "journal article", "authors": ["Bragg Z.", "Rieske L.K."], "title": "Identification of RNAi-Related Genes and Transcriptome Assembly of Loblolly Pine (Pinus taeda, L.) Seedlings Exposed to Insect-Specific dsRNA.", "publicationDate": "2024", "journal": "Forests", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}], "value": "7-56xOP_8", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}], "value": "Whole plant", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WLZ66618.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR466153", "properties": [{"key": "ProteinId", "value": "WLZ66618.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004525", "properties": [{"key": "GoTerm", "value": "F:ribonuclease III activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0030422", "properties": [{"key": "GoTerm", "value": "P:siRNA processing"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd19869", "properties": [{"key": "EntryName", "value": "DSRM_DCL_plant"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd19875", "properties": [{"key": "EntryName", "value": "DSRM_EIF2AK2-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00593", "properties": [{"key": "EntryName", "value": "RIBOc"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "1.10.1520.10:FF:000004", "properties": [{"key": "EntryName", "value": "Endoribonuclease dicer-like 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.160.20", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "2.170.260.10", "properties": [{"key": "EntryName", "value": "paz domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.1520.10", "properties": [{"key": "EntryName", "value": "Ribonuclease III domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR014720", "properties": [{"key": "EntryName", "value": "dsRBD_dom"}]}, {"database": "InterPro", "id": "IPR003100", "properties": [{"key": "EntryName", "value": "PAZ_dom"}]}, {"database": "InterPro", "id": "IPR036085", "properties": [{"key": "EntryName", "value": "PAZ_dom_sf"}]}, {"database": "InterPro", "id": "IPR000999", "properties": [{"key": "EntryName", "value": "RNase_III_dom"}]}, {"database": "InterPro", "id": "IPR036389", "properties": [{"key": "EntryName", "value": "RNase_III_sf"}]}, {"database": "PANTHER", "id": "PTHR14950:SF15", "properties": [{"key": "EntryName", "value": "DICER-LIKE PROTEIN 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14950", "properties": [{"key": "EntryName", "value": "DICER-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14709", "properties": [{"key": "EntryName", "value": "DND1_DSRM"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00035", "properties": [{"key": "EntryName", "value": "dsrm"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02170", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00636", "properties": [{"key": "EntryName", "value": "Ribonuclease_3"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00358", "properties": [{"key": "EntryName", "value": "DSRM"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00949", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00535", "properties": [{"key": "EntryName", "value": "RIBOc"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF54768", "properties": [{"key": "EntryName", "value": "dsRNA-binding domain-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF101690", "properties": [{"key": "EntryName", "value": "PAZ domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF69065", "properties": [{"key": "EntryName", "value": "RNase III domain-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50137", "properties": [{"key": "EntryName", "value": "DS_RBD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50821", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00517", "properties": [{"key": "EntryName", "value": "RNASE_3_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50142", "properties": [{"key": "EntryName", "value": "RNASE_3_2"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "ELYEMRVPVALQGGWNKCTKSVYLHAYIVKFNPVPPDREYTQFALFLESSLPNEAESMNVELHLAHGRIVKTELLPSRSIEFDPSQLRDALNFQEIFLRILLDRQDFRTDYVELGTEDVNLGLSSTSYLLLPVQSCDSKQELCIDWKIIKDCLSSPVFSHESKGLLVADDSGNLLEERDFWRFDNGWVHIDNIRNTLVVTSHNDTFYCIVDILHEINANSYAETMNCSYADYYKKKYNVTLEYREQPFLKAKQLLGLHNLLHDRSQVSPRSQANHGDGAKEEKFVELPAELCYIKLTGFSSPLASAVSLLPSMMHRLENLLVAIELKELLTASFPEGSQITASRVLEAITTERCMEGFSLERLEVLGDAFLKYAVSRRLFLVFDKLDEGQLTKKRSNSIKNSNLYKRAKGKGFPAFIRDEYFDLKQYFALGRPCKNICTPDVEKTIHYFEGDNAMAEMDSLSVKCTKRHHLLHMKTIADVVEALIGAYLVDSGFPAALAFLKWMGIEIDFDASLVGEACLQSRNNLSLIKCIDIDELERLLGYNFIHKGLLLEAFAHPSFNEHNGGCYQRLEFLGDAVLDYIITSYLYSVYPDMKPGYLTDMRSMTVNNESFASVAVRHGLYMYLIQKSDSLSSAVTKYVDFTKSLLTTDRDSYDAPEPKCPKVLGDIVESFAGALVVDTGFDLECVWKLVLRILEPIVTPETLCIQPVRELSEVCQHHNLTLDYRKVPKGNGFLVEANVSGKKVSGFVGGTGTRTSIKDAKKVASKDALLKLKGFGLEHPHKILEVFIRTCRKGSAVLVGKNKAEQATSNIIITERLEEHKFLPSRASCSRDLHGVRSTSEFISTGTASPQKNASTICEQPQLLSTSLTENDMSSTNQNQEADQEYTNSDHHYEIANTTEYQWPSASWDTDIDQFLGSAKSSLNEFCQKRSWEVPEWVCYKEEGMPHQKSFTYMAVLKLPENICIECLGEPKKNKRLAMESASRGALWWLNSQGYL", "length": 997, "molWeight": 112773, "crc64": "31DF3530AE90AF06", "md5": "9CB42439C403F0E6C9D21988C3D18476"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 2}, "countByFeatureType": {"Domain": 4, "Non-terminal residue": 1}, "uniParcId": "UPI0035D314B1"}, "cluster_size": 1, "family": "Pinaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7EBV9", "uniProtkbId": "A0AAU7EBV9_TERTR", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Terebratalia transversa", "commonName": "Transverse lampshell", "taxonId": 34513, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48606.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Brachiopoda", "Rhynchonelliformea", "Rhynchonellata", "Terebratellidina", "Laqueoidea", "Laqueidae", "Terebratalia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48606.1"}], "value": "SFRP1/2/5 protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48606.1"}], "value": "sfrp1/2/5"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010054"}], "value": "Belongs to the secreted frizzled-related protein (sFRP) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043851325"}, {"type": "Domain", "location": {"start": {"value": 36, "modifier": "EXACT"}, "end": {"value": 153, "modifier": "EXACT"}}, "description": "FZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50038"}]}, {"type": "Domain", "location": {"start": {"value": 163, "modifier": "EXACT"}, "end": {"value": 315, "modifier": "EXACT"}}, "description": "NTR", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50189"}]}, {"type": "Region", "location": {"start": {"value": 331, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 348, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 51, "modifier": "EXACT"}, "end": {"value": 97, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 116, "modifier": "EXACT"}, "end": {"value": 140, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022782"}], "id": "KW-0221", "category": "Biological process", "name": "Differentiation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00090"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022687"}], "id": "KW-0879", "category": "Biological process", "name": "Wnt signaling pathway"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-AKIT4T8HERMEG", "citationType": "submission", "authors": ["Vellutini B.C.", "Martin-Duran J.M.", "Borve A.", "Hejnol A."], "title": "Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBK48606.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP860513", "properties": [{"key": "ProteinId", "value": "XBK48606.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0017147", "properties": [{"key": "GoTerm", "value": "F:Wnt-protein binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0060070", "properties": [{"key": "GoTerm", "value": "P:canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030154", "properties": [{"key": "GoTerm", "value": "P:cell differentiation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0035567", "properties": [{"key": "GoTerm", "value": "P:non-canonical Wnt signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "FunFam", "id": "1.10.2000.10:FF:000001", "properties": [{"key": "EntryName", "value": "secreted frizzled-related protein 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.50.120", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.2000.10", "properties": [{"key": "EntryName", "value": "Frizzled cysteine-rich domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR015526", "properties": [{"key": "EntryName", "value": "Frizzled/SFRP"}]}, {"database": "InterPro", "id": "IPR020067", "properties": [{"key": "EntryName", "value": "Frizzled_dom"}]}, {"database": "InterPro", "id": "IPR036790", "properties": [{"key": "EntryName", "value": "Frizzled_dom_sf"}]}, {"database": "InterPro", "id": "IPR001134", "properties": [{"key": "EntryName", "value": "Netrin_domain"}]}, {"database": "InterPro", "id": "IPR018933", "properties": [{"key": "EntryName", "value": "Netrin_module_non-TIMP"}]}, {"database": "InterPro", "id": "IPR008993", "properties": [{"key": "EntryName", "value": "TIMP-like_OB-fold"}]}, {"database": "PANTHER", "id": "PTHR11309", "properties": [{"key": "EntryName", "value": "FRIZZLED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11309:SF148", "properties": [{"key": "EntryName", "value": "SECRETED FRIZZLED-RELATED PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01392", "properties": [{"key": "EntryName", "value": "Fz"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01759", "properties": [{"key": "EntryName", "value": "NTR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00063", "properties": [{"key": "EntryName", "value": "FRI"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF63501", "properties": [{"key": "EntryName", "value": "Frizzled cysteine-rich domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50242", "properties": [{"key": "EntryName", "value": "TIMP-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50038", "properties": [{"key": "EntryName", "value": "FZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50189", "properties": [{"key": "EntryName", "value": "NTR"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MPIYLFVVFLIYVGSSRGNNFDMQWTNSWTLLTGRVAQPQCVVIPANLTLCHDIGYTKMRLPNLLDQDTLKEVTHQAQSWVHLIRRQCHPDLKLFLCSLYSPVCLDRFIWPCRSLCEAVKKDCEAPMMKWGYPWPEMARCDKFPLDNDMCIQSIKGNTSADVCKACDQPDTIERILDGFCGPSSTAAPGKPTAVETSAEFVMKVKIRKFSFTGNYWKITTQKRKKDYLGSLKKKEKKGKLYIKANDISKVCGCNQLNNSRSTQYLIMGNKVKDPRSGQVRLVLSYIAVWPRKNKDPAKHKEFQEAIKKIKQKDFCRTTAMQAFIKPVKSLEIPKNNRAVSSSNGSKKGNGKKRRTGRRNRKRKGGRRGASKHASKN", "length": 376, "molWeight": 42853, "crc64": "5B7CD298AD9B990A", "md5": "612B2C6ADA501373882B564E4CDFF3AD"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2, "Region": 1, "Compositional bias": 1, "Disulfide bond": 2}, "uniParcId": "UPI0035D34EAB"}, "cluster_size": 1, "family": "Laqueidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N814", "uniProtkbId": "A0AAN0N814_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34089.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34089.1"}], "value": "G protein-coupled receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 38, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 50, "modifier": "EXACT"}, "end": {"value": 76, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 88, "modifier": "EXACT"}, "end": {"value": 109, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 130, "modifier": "EXACT"}, "end": {"value": 154, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 185, "modifier": "EXACT"}, "end": {"value": 203, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 758, "modifier": "EXACT"}, "end": {"value": 778, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 30, "modifier": "EXACT"}, "end": {"value": 808, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34089.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155015", "properties": [{"key": "ProteinId", "value": "WRW34089.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0071880", "properties": [{"key": "GoTerm", "value": "P:adenylate cyclase-activating adrenergic receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0043410", "properties": [{"key": "GoTerm", "value": "P:positive regulation of MAPK cascade"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24248", "properties": [{"key": "EntryName", "value": "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24248:SF204", "properties": [{"key": "EntryName", "value": "HISTAMINE H1 RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MILQSQNQPNFLSILLVFILYSLSLLTFLGNAIVVHAIRTERKLRTVSNMYILSLAIADLIVGAIVMPISSTYVLTKEWIFGRSICQFWLIVDYSASTASIFNLLILSLDRYYSIKNPLKYLRKRTKKRALAMICVVWLISFSWALPILFWHIWNNPKGLRKHTETICETEFSDNMLFKLTSSSVNFLLPICLMMLLYAKIFLEIKSRGKLNIGRYSTSLKASSTSHSNLEQICLKDNELKYCSKKDFFKNTDKIEKKEQKNLKYFKNHSFRFREEKNYEKNMIKKTFNKCYENKKKNFNRATWSGKNIEKNKKVFRFSKSLDNLNKCRVNEEIESLKLFYKIYDDQILTKNKKIMTNEIFTNKNKEIKKPALENEKLIKINKKQKINYMFFNQEDKFSKELKTFENVIDSEIFMNKEKEKFLKLKSLKDENNINEINKKKSNGLNSRISFRNNFVLSKRINMNKTKKNSQQNINYNEKKLLLPPKVFINSKKHFNLKAEKCKLIQNNEHNLNSKNQFFNTNSKNQNSFIYKRNEDEKINFKNIEKIRKKYKSKSSWLSNLVSLSSISRSCDKNFKKSKIKKQQKCIDKHYNSKNRKSKSLENICNLENTSLKIIKNKSINSFFIYQNNCSSFFNKSLVYIQQNYENSFNEQINDLKTRSSISLNYINEQKNYLDATKFLRASNENSISPSNIKFEPCKQNLKKKNTSPNSSKSISLIYNLKKNNTDQMSCRSNPTSIHFNKIESSRLKQEKKAARQLGVIMGGFLICWLPYITVYIITAKCQCISTTFHTISIWLGYFNSTLNPFLYALCNDNFKQAFRKLLAKCCNQKNLAEKNYNGIAINNHNTINVSTRKKK", "length": 856, "molWeight": 100720, "crc64": "8ABA51659858B204", "md5": "58943F56631E0E23D5AB10656500FEB2"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6, "Domain": 1}, "uniParcId": "UPI00324ADD19"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6NDC8", "uniProtkbId": "A0AAU6NDC8_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59718.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59718.1"}], "value": "OBP2"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 21, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 22, "modifier": "EXACT"}, "end": {"value": 145, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043862344"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59718.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420078", "properties": [{"key": "ProteinId", "value": "WWA59718.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00708", "properties": [{"key": "EntryName", "value": "PhBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSDFTCIILCALVMSISRVDAGVPLGLGDINAILLDCANKNKVTNDQLRAVVKSQDTTNVNPCFFACLFKKSRFLNGKGDLDVNAGLAYVKQVMPNRPEIAMVENVVKKCESVKNVPVKDGAAGCERAALVVACLVEQKKTLKPK", "length": 145, "molWeight": 15628, "crc64": "2B4D26DF174A9DAA", "md5": "125C842E1689D75AB8C509689E7F3A00"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D3256B"}, "cluster_size": 3, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8HXQ0", "uniProtkbId": "A0AAU8HXQ0_9TELE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Astyanax altiparanae", "taxonId": 142828, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71666.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Ostariophysi", "Characiformes", "Characoidei", "Acestrorhamphidae", "Acestrorhamphinae", "Astyanax"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71666.1"}], "value": "Progesterone receptor"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71666.1"}], "value": "pgr"}}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 41, "modifier": "EXACT"}}, "description": "Nuclear receptor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51030"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71666.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 84, "modifier": "EXACT"}, "end": {"value": 84, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71666.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71666.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-8QAMRIAJBPKUI", "citationType": "submission", "authors": ["Abreu M.R.", "Batlouni S.R."], "title": "Molecular and hormonal mechanisms underlying oocyte maturation and ovulation and its application to seed production in the lambari (Astyanax altiparanae).", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71666.1"}], "value": "Ovary", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI71666.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP964784", "properties": [{"key": "ProteinId", "value": "XCI71666.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0043565", "properties": [{"key": "GoTerm", "value": "F:sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "FunFam", "id": "3.30.50.10:FF:000137", "properties": [{"key": "EntryName", "value": "GR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.50.10", "properties": [{"key": "EntryName", "value": "Erythroid Transcription Factor GATA-1, subunit A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050200", "properties": [{"key": "EntryName", "value": "Nuclear_hormone_rcpt_NR3"}]}, {"database": "InterPro", "id": "IPR001628", "properties": [{"key": "EntryName", "value": "Znf_hrmn_rcpt"}]}, {"database": "InterPro", "id": "IPR013088", "properties": [{"key": "EntryName", "value": "Znf_NHR/GATA"}]}, {"database": "PANTHER", "id": "PTHR48092", "properties": [{"key": "EntryName", "value": "KNIRPS-RELATED PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00105", "properties": [{"key": "EntryName", "value": "zf-C4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00399", "properties": [{"key": "EntryName", "value": "ZnF_C4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57716", "properties": [{"key": "EntryName", "value": "Glucocorticoid receptor-like (DNA-binding domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51030", "properties": [{"key": "EntryName", "value": "NUCLEAR_REC_DBD_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "YKYLCAGRNDCIVDKIRRKNCPACRLRKCYQAGMMLGGRKLKRFGVLKAMGFNPSLMFQNPLTLPVEPHALSTISCMPAIRELQ", "length": 84, "molWeight": 9534, "crc64": "BCC910D818B5BE79", "md5": "CEA72033E32EAE5E014C93A093F2EBB3"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI0035D39F1E"}, "cluster_size": 1, "family": "Acestrorhamphidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZES5", "uniProtkbId": "A0AB38ZES5_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02768.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02768.1"}], "value": "Venom cystatin 8"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 156, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044307157"}, {"type": "Domain", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 124, "modifier": "EXACT"}}, "description": "Cystatin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00031"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02768.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517518", "properties": [{"key": "ProteinId", "value": "WXI02768.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004869", "properties": [{"key": "GoTerm", "value": "F:cysteine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00042", "properties": [{"key": "EntryName", "value": "CY"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.10.450.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000010", "properties": [{"key": "EntryName", "value": "Cystatin_dom"}]}, {"database": "InterPro", "id": "IPR046350", "properties": [{"key": "EntryName", "value": "Cystatin_sf"}]}, {"database": "Pfam", "id": "PF00031", "properties": [{"key": "EntryName", "value": "Cystatin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54403", "properties": [{"key": "EntryName", "value": "Cystatin/monellin"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFRSTIVILIFASVGLLEYGSASWVDDLLKHPPKNWPCLGCEEGMMKDQMMNVNLRKLSNIPKPKKWPCLGCEDEISTDDRMMKKSLRMVLAEQNSKFKLVKVLKATQQTTDGYSYKIKCVVKVAGTDDEKTCNVSFTVTAGMEPQLMRLSRFDCK", "length": 156, "molWeight": 17723, "crc64": "E9B0818BCFFFD3BD", "md5": "2407E25C80C36695C4FA331AABF00E5D"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI00388C1B28"}, "cluster_size": 1, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VGH8", "uniProtkbId": "A0AAU7VGH8_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67472.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67472.1"}], "value": "Piwi-like protein 1B"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67472.1"}], "value": "piwi1B"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}], "value": "Cytoplasm", "id": "SL-0086"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00038291"}], "value": "Belongs to the argonaute family. Piwi subfamily"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 264, "modifier": "EXACT"}, "end": {"value": 378, "modifier": "EXACT"}}, "description": "PAZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50821"}]}, {"type": "Domain", "location": {"start": {"value": 543, "modifier": "EXACT"}, "end": {"value": 835, "modifier": "EXACT"}}, "description": "Piwi", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50822"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 89, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 11, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 52, "modifier": "EXACT"}, "end": {"value": 68, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022473"}], "id": "KW-0217", "category": "Molecular function", "name": "Developmental protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022782"}], "id": "KW-0221", "category": "Biological process", "name": "Differentiation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022884"}], "id": "KW-0694", "category": "Molecular function", "name": "RNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023158"}], "id": "KW-0943", "category": "Biological process", "name": "RNA-mediated gene silencing"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67472.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67472.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750677", "properties": [{"key": "ProteinId", "value": "XBW67472.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0003723", "properties": [{"key": "GoTerm", "value": "F:RNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0030154", "properties": [{"key": "GoTerm", "value": "P:cell differentiation"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0031047", "properties": [{"key": "GoTerm", "value": "P:regulatory ncRNA-mediated gene silencing"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd02845", "properties": [{"key": "EntryName", "value": "PAZ_piwi_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd04658", "properties": [{"key": "EntryName", "value": "Piwi_piwi-like_Euk"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.420.10:FF:000014", "properties": [{"key": "EntryName", "value": "Piwi-like RNA-mediated gene silencing 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.170.260.10:FF:000003", "properties": [{"key": "EntryName", "value": "Piwi-like RNA-mediated gene silencing 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.170.260.10", "properties": [{"key": "EntryName", "value": "paz domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.10", "properties": [{"key": "EntryName", "value": "Ribonuclease H-like superfamily/Ribonuclease H"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR014811", "properties": [{"key": "EntryName", "value": "ArgoL1"}]}, {"database": "InterPro", "id": "IPR003100", "properties": [{"key": "EntryName", "value": "PAZ_dom"}]}, {"database": "InterPro", "id": "IPR036085", "properties": [{"key": "EntryName", "value": "PAZ_dom_sf"}]}, {"database": "InterPro", "id": "IPR003165", "properties": [{"key": "EntryName", "value": "Piwi"}]}, {"database": "InterPro", "id": "IPR012337", "properties": [{"key": "EntryName", "value": "RNaseH-like_sf"}]}, {"database": "InterPro", "id": "IPR036397", "properties": [{"key": "EntryName", "value": "RNaseH_sf"}]}, {"database": "PANTHER", "id": "PTHR22891", "properties": [{"key": "EntryName", "value": "EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08699", "properties": [{"key": "EntryName", "value": "ArgoL1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02170", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02171", "properties": [{"key": "EntryName", "value": "Piwi"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23278", "properties": [{"key": "EntryName", "value": "Piwi_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00949", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00950", "properties": [{"key": "EntryName", "value": "Piwi"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF101690", "properties": [{"key": "EntryName", "value": "PAZ domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53098", "properties": [{"key": "EntryName", "value": "Ribonuclease H-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50821", "properties": [{"key": "EntryName", "value": "PAZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50822", "properties": [{"key": "EntryName", "value": "PIWI"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDARGDSAMGRARGRARGRAAPRPGEADELAVRPGSGGPLPAENQYNGGRSGASDGVSSLSSRMQSVSIDPVRSETPLPPIRIPESGPEDGAEKVEIIANSFLLRRRPAFALYQYHVDFEPCVPSKEMRNMMMAEQVGTIGQVFEFDGMGLLFIPVQLRDPITELSSIRKTDKREIAIRLKFVAEVGNDDLSTQLQLYNVIFKRILKFSELKCVGRNYYSPAEAVPIPQHKLEVWPGFISSILDCKKSPMLIMDVSHKILHTGTVLQLMYDMLKECRHNVTVFQEMCSKKLIGQIVLTRYNNKTYRIDSINWNGTPKSPFTRSDGTEELFMDYFQRAYGIRLTDMDQPLLCSNPKSKGRGGSGEDLLILLPELCYLTGLMDEVRTDYSIMRDIATHTRVEPATRVRTLESFISKLNRNPEAKNHAEAWNLEFADKLHTLIGKRCKKEQVYQGTEELFYNAANADWSREMKNKRFTAPISLDKWVVIVNDRDKKLAGELVDMLGRICPPTGVNVRECEAVVLPDDSNASYLKALREKVNSSVQIVVCIVPSNRADRYNAIKTFCCIENPVPSQVVVARTLMKSNMLSSVASKIAIQMNCKLGGEVWNLQVPISGLMVVGIDCYHDSSKKGRSVGAFVASFNKGLTRYYSRCVPQAEQQEIVDTLNVFMSDAIKHFKKVNGSYPGTIIAYRDGVGDGQVQVVSKYEVKQILESFKTIEPGYCPKFSFIIVKKRINSRFFARTDRGITNPPPGTVIDADVTHPKWYDFFLISQSVRQGTVSPTNYNVIYDNSNLKAIQQQRLAYKLTHLYYNWPGTIRVPAPCQYAHKLAFLVGQTLHREADQKLYDHLYYL", "length": 849, "molWeight": 95685, "crc64": "16107E723647BA1C", "md5": "53666128928F1D4F28E1D4A6257A6D93"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2, "Region": 1, "Compositional bias": 2}, "uniParcId": "UPI0035D33A85"}, "cluster_size": 2, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHW4", "uniProtkbId": "A0AAN0LHW4_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65902.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65902.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65902.1"}], "value": "UGT"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009995"}], "value": "Belongs to the UDP-glycosyltransferase family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65902.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145355", "properties": [{"key": "ProteinId", "value": "WRV65902.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050271", "properties": [{"key": "EntryName", "value": "UDP-glycosyltransferase"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48043", "properties": [{"key": "EntryName", "value": "EG:EG0003.4 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48043:SF145", "properties": [{"key": "EntryName", "value": "FI06409P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00201", "properties": [{"key": "EntryName", "value": "UDPGT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVKICFVLLLERGHFTICSAIGKYLLAKDIKNEIYFIVDDEFENIVRDDCNLFKIVKFKQPEIVNKSPIVLNKILDTWKLDKYERYGFFCEKFISLLNLWRNRDKLIAGLIDELKPDFVFIENLFNIPSLMNKDYKWGMIISTNPLRIGDQENHFPMNTGCVDKEEAKKYLNIFKEKSKNFFHSLDDWYKENNLIRKPSLSYVQGSEYLNIFLFPEELNYFQPNELSGKWFQIENTIINSSVENKMKIYQNFNPTGKEILTKEFLQKPGKLILVSLGTVLTRNIDLFKEIIPFMKNIPHKFIVSKGKFGDQIELPNNCIGSNFLNQLEFLPMVDLFISHGGNNSLCEAFYFGVPMVIIPGFGDQIDNAAILENKKLSKTIFLNDFTEENLKKSIDFMFKNENIKNEMSKISEKIKKKDKLNELCELILKECSA", "length": 433, "molWeight": 50600, "crc64": "9D55EA9AD781EACA", "md5": "BDE7799777D8274EE3F29D1158F53DC7"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI00325139B1"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BIJ4", "uniProtkbId": "A0AAQ5BIJ4_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520484.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520484.1"}], "value": "Ubiquitin specific peptidase 18"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520484.1"}], "value": "USP18"}}], "features": [{"type": "Region", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BIJ4"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520484.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520484.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "18477386", "citationType": "journal article", "authors": ["Cole C.G.", "McCann O.T.", "Collins J.E.", "Oliver K.", "Willey D.", "Gribble S.M.", "Yang F.", "McLaren K.", "Rogers J.", "Ning Z.", "Beare D.M.", "Dunham I."], "citationCrossReferences": [{"database": "PubMed", "id": "18477386"}, {"database": "DOI", "id": "10.1186/gb-2008-9-5-r78"}], "title": "Finishing the finished human chromosome 22 sequence.", "publicationDate": "2008", "journal": "Genome Biol.", "firstPage": "R78", "lastPage": "R78", "volume": "9"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520484.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000520484.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC008079", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000715585.1", "properties": [{"key": "ProteinId", "value": "ENSP00000520484.1"}, {"key": "GeneId", "value": "ENSG00000184979.12"}]}, {"database": "HGNC", "id": "HGNC:12616", "properties": [{"key": "GeneName", "value": "USP18"}]}, {"database": "OpenTargets", "id": "ENSG00000184979", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00940000161720", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 22"}]}], "sequence": {"value": "MSKAFGLLRQICQSILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDYPHGH", "length": 54, "molWeight": 6312, "crc64": "377D3AE91A45CDE7", "md5": "E533639D894A671027D6B78344A7EF76"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 1}, "uniParcId": "UPI0032CDBC44"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHV3", "uniProtkbId": "A0AAN0LHV3_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65887.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65887.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65887.1"}], "value": "UGT"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009995"}], "value": "Belongs to the UDP-glycosyltransferase family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 7, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 1141, "modifier": "EXACT"}, "end": {"value": 1225, "modifier": "EXACT"}}, "description": "Glycosyl transferase family 28 C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF04101"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65887.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145340", "properties": [{"key": "ProteinId", "value": "WRV65887.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016758", "properties": [{"key": "GoTerm", "value": "F:hexosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "6"}]}, {"database": "InterPro", "id": "IPR007235", "properties": [{"key": "EntryName", "value": "Glyco_trans_28_C"}]}, {"database": "InterPro", "id": "IPR050271", "properties": [{"key": "EntryName", "value": "UDP-glycosyltransferase"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48043", "properties": [{"key": "EntryName", "value": "EG:EG0003.4 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48043:SF145", "properties": [{"key": "EntryName", "value": "FI06409P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF04101", "properties": [{"key": "EntryName", "value": "Glyco_tran_28_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00201", "properties": [{"key": "EntryName", "value": "UDPGT"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "3"}]}], "sequence": {"value": "MSEKKKIAFYTVLASGHFNFTSSIATTLLNLYSDKIETYFFTDHEWCKKLSKIDSRFKFEIIEYEEKKQKDFINKMAESMEPILSLSNLDKLKATYKSFFENDDFLYIDQKVSKLIEKLKPDYLLCDLACHMPAMVESGIPYSFIISCNPLLLNIESLPICGLDLRTIDKEQIKETRKELEDFYKEINNHLELNYSKRNVKYNGKYPASQTRSEHLSFYCYPKELDYFNDELKTDYKLLQVDSPIVLSRIPPPFDFSKEFAELPGKIIYVSLGSVFSCYYTKLQKLLDTLATLPYKYIVSKGPNGDKIKFPDNRFIGENFVDQLAILQVVDIMIAHGGNNTFTECFYFGVPAIIFPMIGDQINNASRLEETGFGDRMNLMDYSQKELESKLNRILNDNLLINNIKNITFYNYLTSGHMNLSVSVVPTLLDNYSDEIDVFFFVDYLWAEKLSKIDLRFKFEIFEKKESKNEEINAFIGILEPLLNLSEKERTKNLLKLTNDSKDLSFDDEVSVLIKKLKPDYLLCDLVYHMPSLLECKIPYSFIISANPLILNIEDFPLIGVGHGIDEKEKIKAARLEFKEIFGFITKKFESSYEKLNVKLDKKIPVYSPKSEYFSIYSYPKEIDYFDENQRKKYNLLQVDSPVVSSRVPAPYHLSEEFIKLPGKIIYVSLGSLFGYYYVKLQKLLDALATLPYKYIVSKGPFGEKIKFPNERFIRENYVNQFAVLQVVDMMIAHGGNNTLTECFYFGVPALIIPIIGDQPNNAKRLEETGFGYRINLMNYTQEELKEKINKILSDEILIEKTKKVGERIRNEKSLEKAKNVSKKKIGLYNYLSSGHTNVSTAIASILLDNYSDELDVYFFVDDTWAEKLKKKDSRFKFEIFEKEKINKNEEVFDFIKLFEPILSLPEVEKFKKGVEILHKDNNIVCDEQVSKAIKKLKPDYLLCDVAFHMACLIECKIPYSFVISCNPLILDVEELPVCGITHGVDEKEKIKAVRLELKETFDFITKKFESSYEKFKVKFEKNYPVYSPRSDYLSIYSYPKEVDYFNDELKKNYKLLQIDSPIVPSRIPPPFELPKEFAKLPGKIIYVSLGSMFSCYHTKLQKLLDTLAILPYKYIVSKGPNGDKITFPDNRFIGENFVNQLAILQVADMMIAHGGNNTFTECFYFGVPSIIFPMIGDQLNNAKRIEETGFGYRMDLMNYTQEELKYKINKILSDESLIEKNKKAGERIRNEKSLEKAVKIFYESIKNKNNNLVVKN", "length": 1257, "molWeight": 145939, "crc64": "3B3E85095DD760DC", "md5": "FA885F16F5FA04FC11DF9176972A092F"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1}, "uniParcId": "UPI00324E15B6"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAE4VJZ3", "uniProtkbId": "A0AAE4VJZ3_9RICK", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 3.0, "organism": {"scientificName": "Lyticum sinuosum", "taxonId": 1332059, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MDZ5761365.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001289135"}], "lineage": ["Bacteria", "Pseudomonadati", "Pseudomonadota", "Alphaproteobacteria", "Rickettsiales", "Lyticum"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001174"}], "value": "Lon protease"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001174"}], "value": "3.4.21.53"}]}, "alternativeNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "value": "ATP-dependent protease La"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "value": "lon"}, "orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MDZ5761365.1"}], "value": "Lyticum_00538"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "value": "ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner"}], "commentType": "FUNCTION"}, {"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "Hydrolysis of proteins in presence of ATP.", "ecNumber": "3.4.21.53", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00050665"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001174"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01122"}]}}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001174"}], "value": "Homohexamer. Organized in a ring with a central cavity"}], "commentType": "SUBUNIT"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004496"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001174"}], "value": "Cytoplasm", "id": "SL-0086"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "value": "By heat shock"}], "commentType": "INDUCTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}, {"evidenceCode": "ECO:0000256", "source": "PIRNR", "id": "PIRNR001174"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01122"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000591"}], "value": "Belongs to the peptidase S16 family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MDZ5761365.1"}], "value": "The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}], "commentType": "CAUTION"}], "features": [{"type": "Domain", "location": {"start": {"value": 26, "modifier": "EXACT"}, "end": {"value": 224, "modifier": "EXACT"}}, "description": "Lon N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51787"}]}, {"type": "Domain", "location": {"start": {"value": 641, "modifier": "EXACT"}, "end": {"value": 822, "modifier": "EXACT"}}, "description": "Lon proteolytic", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51786"}]}, {"type": "Active site", "location": {"start": {"value": 728, "modifier": "EXACT"}, "end": {"value": 728, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR001174-1"}]}, {"type": "Active site", "location": {"start": {"value": 771, "modifier": "EXACT"}, "end": {"value": 771, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR001174-1"}]}, {"type": "Binding site", "location": {"start": {"value": 375, "modifier": "EXACT"}, "end": {"value": 382, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR001174-2"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022490"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001289135"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022825"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023016"}, {"evidenceCode": "ECO:0000256", "source": "HAMAP-Rule", "id": "MF_01973"}], "id": "KW-0346", "category": "Biological process", "name": "Stress response"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-6UKAIVJN6L6R", "citationType": "submission", "authors": ["Castelli M.", "Nardi T.", "Gammuto L.", "Bellinzona G.", "Sabaneyeva E.", "Potekhin A.", "Serra V.", "Petroni G.", "Sassera D."], "title": "Host association and intracellularity evolved multiple times independently in the Rickettsiales.", "publicationDate": "FEB-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MDZ5761365.1"}], "value": "USBL-36I1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "MDZ5761365.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "JARGYU010000002", "properties": [{"key": "ProteinId", "value": "MDZ5761365.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "RefSeq", "id": "WP_322498794.1", "properties": [{"key": "NucleotideSequenceId", "value": "NZ_JARGYU010000002.1"}]}, {"database": "Proteomes", "id": "UP001289135", "properties": [{"key": "Component", "value": "Unassembled WGS sequence"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0016887", "properties": [{"key": "GoTerm", "value": "F:ATP hydrolysis activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0004176", "properties": [{"key": "GoTerm", "value": "F:ATP-dependent peptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0043565", "properties": [{"key": "GoTerm", "value": "F:sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0034605", "properties": [{"key": "GoTerm", "value": "P:cellular response to heat"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0006515", "properties": [{"key": "GoTerm", "value": "P:protein quality control for misfolded or incompletely synthesized proteins"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "CDD", "id": "cd19500", "properties": [{"key": "EntryName", "value": "RecA-like_Lon"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.20.5.5270:FF:000002", "properties": [{"key": "EntryName", "value": "Lon protease homolog"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.50.300:FF:000021", "properties": [{"key": "EntryName", "value": "Lon protease homolog"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.8.60", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.5.5270", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.58.1480", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.230.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.30.130.40", "properties": [{"key": "EntryName", "value": "LON domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.300", "properties": [{"key": "EntryName", "value": "P-loop containing nucleotide triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "HAMAP", "id": "MF_01973", "properties": [{"key": "EntryName", "value": "lon_bact"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR003593", "properties": [{"key": "EntryName", "value": "AAA+_ATPase"}]}, {"database": "InterPro", "id": "IPR003959", "properties": [{"key": "EntryName", "value": "ATPase_AAA_core"}]}, {"database": "InterPro", "id": "IPR027543", "properties": [{"key": "EntryName", "value": "Lon_bac"}]}, {"database": "InterPro", "id": "IPR004815", "properties": [{"key": "EntryName", "value": "Lon_bac/euk-typ"}]}, {"database": "InterPro", "id": "IPR054594", "properties": [{"key": "EntryName", "value": "Lon_lid"}]}, {"database": "InterPro", "id": "IPR008269", "properties": [{"key": "EntryName", "value": "Lon_proteolytic"}]}, {"database": "InterPro", "id": "IPR027065", "properties": [{"key": "EntryName", "value": "Lon_Prtase"}]}, {"database": "InterPro", "id": "IPR003111", "properties": [{"key": "EntryName", "value": "Lon_prtase_N"}]}, {"database": "InterPro", "id": "IPR046336", "properties": [{"key": "EntryName", "value": "Lon_prtase_N_sf"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "InterPro", "id": "IPR008268", "properties": [{"key": "EntryName", "value": "Peptidase_S16_AS"}]}, {"database": "InterPro", "id": "IPR015947", "properties": [{"key": "EntryName", "value": "PUA-like_sf"}]}, {"database": "InterPro", "id": "IPR020568", "properties": [{"key": "EntryName", "value": "Ribosomal_Su5_D2-typ_SF"}]}, {"database": "InterPro", "id": "IPR014721", "properties": [{"key": "EntryName", "value": "Ribsml_uS5_D2-typ_fold_subgr"}]}, {"database": "NCBIfam", "id": "TIGR00763", "properties": [{"key": "EntryName", "value": "lon"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43718", "properties": [{"key": "EntryName", "value": "LON PROTEASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43718:SF2", "properties": [{"key": "EntryName", "value": "LON PROTEASE HOMOLOG, MITOCHONDRIAL"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00004", "properties": [{"key": "EntryName", "value": "AAA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF05362", "properties": [{"key": "EntryName", "value": "Lon_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF22667", "properties": [{"key": "EntryName", "value": "Lon_lid"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02190", "properties": [{"key": "EntryName", "value": "LON_substr_bdg"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF001174", "properties": [{"key": "EntryName", "value": "Lon_proteas"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00830", "properties": [{"key": "EntryName", "value": "ENDOLAPTASE"}]}, {"database": "SMART", "id": "SM00382", "properties": [{"key": "EntryName", "value": "AAA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00464", "properties": [{"key": "EntryName", "value": "LON"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF88697", "properties": [{"key": "EntryName", "value": "PUA domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54211", "properties": [{"key": "EntryName", "value": "Ribosomal protein S5 domain 2-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51787", "properties": [{"key": "EntryName", "value": "LON_N"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51786", "properties": [{"key": "EntryName", "value": "LON_PROTEOLYTIC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS01046", "properties": [{"key": "EntryName", "value": "LON_SER"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MENTNNKINKTKLTISKTTKGKYETYPVVPLRDMVMFPRMIVTIYIGRESSISALSKTNNTDNKILLVAQKDSTIDKPDAKDLHKVGVIAKVLHTLKLNESGTRNIKVLVEGQSKCSIHSFKTEEDCLFAKVKIVETTNGNFSEDEIKVMRRSLVEEFEIYVRNNRRISIDILNGILQLKENDTLCNAISAHMPLSGAKKQEILELPNVYKQMESLLVFIKSEINFNEAGRRIQQRVQKQVETNQKHYLLGEQLKAIYAELGENNVHEEYKQLKDIAEKSGMPSSVRKKFDIELQRLKSMSPMSAEANISRVYIDWLKDIPWNKKSNLVNSMDYAENIMNTDHYGLSKVKDRVLEYLAVMMRTQKSLGTVICFVGPPGVGKTSLARSIAKATGREFGKISLGGIRDEAEIRGHRKTYVGAMPGRIVRILKDLGVNNPIILLDEIDKIGGLSEYRGDPSAALLDILDPEQNKYFSDNYLEVEIDLSSVLFICTANSLNISRPLLDRMEIIKISGYVEEEKIAIAKNHLMKKQYKLNGISENELIIVDNAIEDIIRYYTRESGVRNLEREISKIMRKSVRNLISKESCQINAFVEGSNNNISNQENTSSILIENNPILLSISSDNLKEFLGNRKYNIGLIDKKDGIGLCNGLAYTEVGGDLLPIEVLIVPGKGEVKTTGKLGEVMRESIMAAWTHIKYCCSDLNIPSQYFEKHDCHVHVPEGAVPKDGPSAGCAIATAIISSITNIPVRRDIAMTGEISLHGKVLPIGGLKEKVIAAAMGGVSCVFIPQENVKDLEDVPQSAKDAIEFISVSYIHEIWSKALLSPISNHRNTFAIKNDPIVDINGLINKCDIKNEKRNKRKNIINPSCFS", "length": 868, "molWeight": 97213, "crc64": "07C2FEBF6EADE230", "md5": "6AC894AEB0016EFCA51D33CF4B95E842"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "CATALYTIC ACTIVITY": 1, "SUBUNIT": 1, "SUBCELLULAR LOCATION": 1, "INDUCTION": 1, "SIMILARITY": 1, "CAUTION": 1}, "countByFeatureType": {"Domain": 2, "Active site": 2, "Binding site": 1}, "uniParcId": "UPI002ACB2A58"}, "cluster_size": 1, "family": "Unknown_Family_TaxID_1332059"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HBN6", "uniProtkbId": "A0AA96HBN6_9MOLL", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Alexandromenia crassa", "taxonId": 1638916, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25244.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Aplacophora", "Solenogastres", "Cavibelonia", "Amphimeniidae", "Alexandromenia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25244.1"}], "value": "Hypoxia-inducible factor 1"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 9, "modifier": "EXACT"}, "end": {"value": 51, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 122, "modifier": "EXACT"}, "end": {"value": 165, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 280, "modifier": "EXACT"}, "end": {"value": 306, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 325, "modifier": "EXACT"}, "end": {"value": 359, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 126, "modifier": "EXACT"}, "end": {"value": 136, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 143, "modifier": "EXACT"}, "end": {"value": 164, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25244.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 398, "modifier": "EXACT"}, "end": {"value": 398, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25244.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25244.1"}], "value": "Alex1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25244.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354979", "properties": [{"key": "ProteinId", "value": "WNN25244.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013655", "properties": [{"key": "EntryName", "value": "PAS_fold_3"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08447", "properties": [{"key": "EntryName", "value": "PAS_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "PSMIFTSCDDRMTDLVGYSSQDVIGRSVYEYHHAYDHSILVKAHRDLFAKGQAVTDEYRFLVKRGGFVTMISQSTIVYHKSSEPQFVVSVYFVISGVQCRDLILSHVQVPPIRQPLPLITSATQSDEERSENRPEKAPPNQDSNKKTAESDKPAHPHVKTEIPKKLIQRAPCLPKGKDIKLWTKLPKYGISSITMSPIGATESVIVRSKDATHRKFHKYPSLDSSMKGFGAGKIIPGRVALGGLTRNEIPALPRTEPRIESRNEPRIEPRTEPRIELPIEPRIEPCNEPHTEKRTEPRTEPLHDRRLYRERGSLLKCLLLQSSPHINQPSGLPPSLPHSPVSPDSGSEEGRIAQPSCRSTFATRPVQLDDSDMYHAFQHDHVTNLTNLEQRDLETFAP", "length": 398, "molWeight": 44843, "crc64": "257474C4D3A8863E", "md5": "1AF91E02E13F50D033CD02E5C421FFE2"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 3, "Compositional bias": 2, "Non-terminal residue": 2}, "uniParcId": "UPI002B304BDB"}, "cluster_size": 1, "family": "Amphimeniidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA89C4E3", "uniProtkbId": "A0AA89C4E3_PINIB", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pinctada imbricata", "commonName": "Atlantic pearl-oyster", "synonyms": ["Pinctada martensii"], "taxonId": 66713, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK3098851.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001186944"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Bivalvia", "Autobranchia", "Pteriomorphia", "Pterioida", "Pterioidea", "Pteriidae", "Pinctada"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK3098851.1"}], "value": "Uncharacterized protein"}}]}, "genes": [{"orfNames": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK3098851.1"}], "value": "FSP39_023736"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01005"}], "value": "Lacks conserved residue(s) required for the propagation of feature annotation"}], "commentType": "CAUTION"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK3098851.1"}], "value": "The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data"}], "commentType": "CAUTION"}], "features": [{"type": "Domain", "location": {"start": {"value": 694, "modifier": "EXACT"}, "end": {"value": 852, "modifier": "EXACT"}}, "description": "Integrase catalytic", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50994"}]}, {"type": "Domain", "location": {"start": {"value": 982, "modifier": "EXACT"}, "end": {"value": 1016, "modifier": "EXACT"}}, "description": "ShKT", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51670"}]}, {"type": "Domain", "location": {"start": {"value": 1178, "modifier": "EXACT"}, "end": {"value": 1228, "modifier": "EXACT"}}, "description": "BPTI/Kunitz inhibitor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50279"}]}, {"type": "Region", "location": {"start": {"value": 128, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 356, "modifier": "EXACT"}, "end": {"value": 405, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1316, "modifier": "EXACT"}, "end": {"value": 1375, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 356, "modifier": "EXACT"}, "end": {"value": 369, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 376, "modifier": "EXACT"}, "end": {"value": 394, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1344, "modifier": "EXACT"}, "end": {"value": 1367, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 982, "modifier": "EXACT"}, "end": {"value": 1016, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01005"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU01005"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00047216"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP001186944"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-74VK8CR7FS60O", "citationType": "submission", "authors": ["Zheng Z."], "title": "The improved chromosome-level genome for the pearl oyster Pinctada fucata martensii using PacBio sequencing and Hi-C.", "publicationDate": "AUG-2019", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK3098851.1"}], "value": "ZZ-2019", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK3098851.1"}], "value": "Adductor muscle", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "KAK3098851.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "VSWD01000007", "properties": [{"key": "ProteinId", "value": "KAK3098851.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Proteomes", "id": "UP001186944", "properties": [{"key": "Component", "value": "Unassembled WGS sequence"}]}, {"database": "GO", "id": "GO:0003676", "properties": [{"key": "GoTerm", "value": "F:nucleic acid binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004867", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0015074", "properties": [{"key": "GoTerm", "value": "P:DNA integration"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00109", "properties": [{"key": "EntryName", "value": "Kunitz-type"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00146", "properties": [{"key": "EntryName", "value": "PKD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.420.10:FF:000032", "properties": [{"key": "EntryName", "value": "Retrovirus-related Pol polyprotein from transposon 297-like Protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.340.70:FF:000001", "properties": [{"key": "EntryName", "value": "Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.10.1940", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.340.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.4020.10", "properties": [{"key": "EntryName", "value": "DNA breaking-rejoining enzymes"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "4.10.410.10", "properties": [{"key": "EntryName", "value": "Pancreatic trypsin inhibitor Kunitz domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.420.10", "properties": [{"key": "EntryName", "value": "Ribonuclease H-like superfamily/Ribonuclease H"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008969", "properties": [{"key": "EntryName", "value": "CarboxyPept-like_regulatory"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR001584", "properties": [{"key": "EntryName", "value": "Integrase_cat-core"}]}, {"database": "InterPro", "id": "IPR041588", "properties": [{"key": "EntryName", "value": "Integrase_H2C2"}]}, {"database": "InterPro", "id": "IPR002223", "properties": [{"key": "EntryName", "value": "Kunitz_BPTI"}]}, {"database": "InterPro", "id": "IPR036880", "properties": [{"key": "EntryName", "value": "Kunitz_BPTI_sf"}]}, {"database": "InterPro", "id": "IPR035986", "properties": [{"key": "EntryName", "value": "PKD_dom_sf"}]}, {"database": "InterPro", "id": "IPR012337", "properties": [{"key": "EntryName", "value": "RNaseH-like_sf"}]}, {"database": "InterPro", "id": "IPR036397", "properties": [{"key": "EntryName", "value": "RNaseH_sf"}]}, {"database": "InterPro", "id": "IPR003309", "properties": [{"key": "EntryName", "value": "SCAN_dom"}]}, {"database": "InterPro", "id": "IPR038269", "properties": [{"key": "EntryName", "value": "SCAN_sf"}]}, {"database": "InterPro", "id": "IPR003582", "properties": [{"key": "EntryName", "value": "ShKT_dom"}]}, {"database": "PANTHER", "id": "PTHR46888:SF13", "properties": [{"key": "EntryName", "value": "RIBONUCLEASE H"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR46888", "properties": [{"key": "EntryName", "value": "ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF17921", "properties": [{"key": "EntryName", "value": "Integrase_H2C2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF22352", "properties": [{"key": "EntryName", "value": "K319L-like_PKD"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00014", "properties": [{"key": "EntryName", "value": "Kunitz_BPTI"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00665", "properties": [{"key": "EntryName", "value": "rve"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02023", "properties": [{"key": "EntryName", "value": "SCAN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00759", "properties": [{"key": "EntryName", "value": "BASICPTASE"}]}, {"database": "SMART", "id": "SM00131", "properties": [{"key": "EntryName", "value": "KU"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00254", "properties": [{"key": "EntryName", "value": "ShKT"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SUPFAM", "id": "SSF57362", "properties": [{"key": "EntryName", "value": "BPTI-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49464", "properties": [{"key": "EntryName", "value": "Carboxypeptidase regulatory domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49299", "properties": [{"key": "EntryName", "value": "PKD domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47353", "properties": [{"key": "EntryName", "value": "Retrovirus capsid dimerization domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53098", "properties": [{"key": "EntryName", "value": "Ribonuclease H-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50279", "properties": [{"key": "EntryName", "value": "BPTI_KUNITZ_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50994", "properties": [{"key": "EntryName", "value": "INTEGRASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51670", "properties": [{"key": "EntryName", "value": "SHKT"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVFSVTEFLKSPTVDEFESLKKDDLIGLGLHLKLDVKSSMRKQEIRNIVAKELLAKEIFSSYDFPVEPVSSETKMSKFEFELEKMKIQLQFEKEEKGRQFQFEKEEKERQFQIEKEEKERQFQIEREEKERQFEKEEKKSQLEREKQERMHERELQFELEKLKLEKGAKENPVPSPVKSEFDAAKNIRLVPKFHEKSVDKYFPHFEKIAANLKWPRDFWPTLLQSVLIGKAAEVYSALSIAESSDYDKVKDTILRAYQLVPEAYRQKFRKYKKFENQTYVEFAREKEDLFDQWFRSKKIPNSFDNLRQIILIEEFKECVHQDLRTHLEDKNVKTLEEAAVLSDTYALTHKKNFVSKTQSSDSAKTSNFPKKNLQESQSSISSQSPSQGGSTSGPRSERSEASPGGVELGVIDVPLHEIYLKSDLITGPVIVGVRPTLPVQGVSLLLGNDLAGGKVVADPIVCEKITSDVVSDDEDDDLYPACAVTRAMARNRLKEAESTSALNEDHPSKNIDLSDTFMSTIDDSVPETSVRLHVDKSPTVPSDDSYPPLDRGTDALSREQLLSEQTKDPEIIRLSRRALPQEEADKVGECFYIQDGILMRKWRPPDAPPNDVWRVVHQIVVPVAYRGDIMSLAHDTPMADHLGVNKTYNRILSHFYWPKLRKDVSEFCKSCHSCQMVGKPNQVIPPAPLQPIPAFEEPFSRVLVDCVGPLPRTRSGNQYLLTIMCTSTRFPEAMPLRNIKAKTIVKALTKFFSFVGAPKAIQSDQGSNFMSGLFQQVMHELGIRQYKSSAYHPESQGALERFHQTLKTMMKTYCHQYGKDWDEGVHLVLFAAREAVQESLGFSPFELVFGHTVRGPLKLLKEKWLTETSDLNLLDYVSNFKEKLYNACKLFQENDDGVDRVVSPCQDDPRQNCWAYEDVKCIEKYEPWSRKHCPYRCGYCPDPGRNSTVTTAPQSTTQSTVTTHKPVQQQTTLPTLPTGAACQDQLTNCDDFSAESCQGLFKTWALLNCPRRCGYCSGGIDECKDYEDCGRLPDDLCKNSAYATLVKTSCRKYCGLCTVKATTQQPVVTKVPVATVTSPQNYTDQPPVAIATDVVIDYPDTTATLNASLSHDDIGISSYKWEYMGNLNADIRGLYTDTVQLYDLEVGTYEFKLTITDTIGQTDTIKIKVEVVRANNTCELPLDEGVCNAYLPRFYYNQTTQTCESYVYGGCFGNSNNFVTEQQCREFCLVCNKNFDIPVPECCGPICACNHTVEGYVTDASNNATPMANVSVYVSGCYCHPFAFSDDKGHYVMSGLCQDDNTLRFETEGYRSHLETPKYMGNGQYQASAPMEPSSKGPMVTPLNPGNSGTSSSAPQANSNADGQNAMVNPGNVLG", "length": 1375, "molWeight": 155257, "crc64": "684EA6E654F9D5C7", "md5": "1CBEB7877CE910655B3AED11635F40E6"}, "extraAttributes": {"countByCommentType": {"CAUTION": 2}, "countByFeatureType": {"Domain": 3, "Region": 3, "Compositional bias": 3, "Disulfide bond": 1}, "uniParcId": "UPI0029560F5C"}, "cluster_size": 3, "family": "Pteriidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MNS7", "uniProtkbId": "A0AA96MNS7_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50035.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50035.1"}], "value": "Uncharacterized protein 3"}}]}, "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 53, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50035.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460112", "properties": [{"key": "ProteinId", "value": "WNS50035.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MGTEYSHVPTMEPAVATNVSQNHTPPKQKTFEDPRSPTLQVDRTPLKERNDPVSCNTPKNNGPVFKQTQFDPRSPSTALPRTPVNPDQNKRPTLTRTPLSYSRMKDQKRSH", "length": 111, "molWeight": 12579, "crc64": "3269E62C5010DFB3", "md5": "5E4EC288E9967CC58D98A98108DBF6AF"}, "extraAttributes": {"countByFeatureType": {"Region": 1, "Compositional bias": 2}, "uniParcId": "UPI002B309FE7"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "Q3ZC57", "secondaryAccessions": ["A0AAA9SE29", "F6QBK4"], "uniProtkbId": "Q3ZC57_BOVIN", "entryAudit": {"firstPublicDate": "2005-09-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2005-09-27", "entryVersion": 131, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Bos taurus", "commonName": "Bovine", "taxonId": 9913, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "AAI02907.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Laurasiatheria", "Artiodactyla", "Ruminantia", "Pecora", "Bovidae", "Bovinae", "Bos"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000082077.2"}], "value": "Enoyl-CoA delta isomerase 2"}}, {"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "AAI02907.1"}], "value": "Peroxisomal D3,D2-enoyl-CoA isomerase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000082077.2"}, {"evidenceCode": "ECO:0000313", "source": "VGNC", "id": "VGNC:28310"}], "value": "ECI2"}, "synonyms": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "AAI02907.1"}], "value": "PECI"}]}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00005567"}], "value": "Belongs to the ACBP family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 38, "modifier": "EXACT"}, "end": {"value": 123, "modifier": "EXACT"}}, "description": "ACB", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51228"}]}, {"type": "Region", "location": {"start": {"value": 118, "modifier": "EXACT"}, "end": {"value": 142, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 118, "modifier": "EXACT"}, "end": {"value": 129, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "AAI02907.1"}], "id": "KW-0413", "category": "Molecular function", "name": "Isomerase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023121"}], "id": "KW-0446", "category": "Ligand", "name": "Lipid-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000009136"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-19M5PSS4FER8T", "citationType": "submission", "authors": ["Moore S.", "Alexander L.", "Brownstein M.", "Guan L.", "Lobo S.", "Meng Y.", "Tanaguchi M.", "Wang Z.", "Yu J.", "Prange C.", "Schreiber K.", "Shenmen C.", "Wagner L.", "Bala M.", "Barbazuk S.", "Barber S.", "Babakaiff R.", "Beland J.", "Chun E.", "Del Rio L.", "Gibson S.", "Hanson R.", "Kirkpatrick R.", "Liu J.", "Matsuo C.", "Mayo M.", "Santos R.R.", "Stott J.", "Tsai M.", "Wong D.", "Siddiqui A.", "Holt R.", "Jones S.J.", "Marra M.A."], "publicationDate": "AUG-2005", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "AAI02907.1"}], "value": "Hereford", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "AAI02907.1"}], "value": "Heart ventrical", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "AAI02907.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DV49K6FT0EEMD", "citationType": "submission", "authors": ["Rosen B.D.", "Bickhart D.M.", "Koren S.", "Schnabel R.D.", "Hall R.", "Zimin A.", "Dreischer C.", "Schultheiss S.", "Schroeder S.G.", "Elsik C.G.", "Couldrey C.", "Liu G.E.", "Van Tassell C.P.", "Phillippy A.M.", "Smith T.P.L.", "Medrano J.F."], "title": "ARS-UCD1.2.", "publicationDate": "MAR-2018", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000082077.2"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000009136"}], "value": "Hereford", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000082077.2"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000009136"}]}, {"referenceNumber": 3, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000082077.2"}], "value": "Hereford", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000082077.2"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "BC102906", "properties": [{"key": "ProteinId", "value": "AAI02907.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "AlphaFoldDB", "id": "Q3ZC57", "properties": [{"key": "Description", "value": "-"}]}, {"database": "SMR", "id": "Q3ZC57", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENSBTAT00000127429.2", "properties": [{"key": "ProteinId", "value": "ENSBTAP00000082077.2"}, {"key": "GeneId", "value": "ENSBTAG00000015178.8"}]}, {"database": "VEuPathDB", "id": "HostDB:ENSBTAG00000015178", "properties": [{"key": "Description", "value": "-"}]}, {"database": "VGNC", "id": "VGNC:28310", "properties": [{"key": "GeneName", "value": "ECI2"}]}, {"database": "GeneTree", "id": "ENSGT00940000155105", "properties": [{"key": "Description", "value": "-"}]}, {"database": "HOGENOM", "id": "CLU_118853_0_0_1", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000009136", "properties": [{"key": "Component", "value": "Chromosome 23"}]}, {"database": "Bgee", "id": "ENSBTAG00000015178", "properties": [{"key": "ExpressionPatterns", "value": "Expressed in corpus luteum and 104 other cell types or tissues"}]}, {"database": "GO", "id": "GO:0000062", "properties": [{"key": "GoTerm", "value": "F:fatty-acyl-CoA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016853", "properties": [{"key": "GoTerm", "value": "F:isomerase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00435", "properties": [{"key": "EntryName", "value": "ACBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.20.80.10:FF:000026", "properties": [{"key": "EntryName", "value": "Enoyl-CoA delta isomerase 2, mitochondrial"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.80.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.300.220", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.90.226.10", "properties": [{"key": "EntryName", "value": "2-enoyl-CoA Hydratase, Chain A, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR022408", "properties": [{"key": "EntryName", "value": "Acyl-CoA-binding_prot_CS"}]}, {"database": "InterPro", "id": "IPR000582", "properties": [{"key": "EntryName", "value": "Acyl-CoA-binding_protein"}]}, {"database": "InterPro", "id": "IPR035984", "properties": [{"key": "EntryName", "value": "Acyl-CoA-binding_sf"}]}, {"database": "InterPro", "id": "IPR029045", "properties": [{"key": "EntryName", "value": "ClpP/crotonase-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR001753", "properties": [{"key": "EntryName", "value": "Enoyl-CoA_hydra/iso"}]}, {"database": "InterPro", "id": "IPR014352", "properties": [{"key": "EntryName", "value": "FERM/acyl-CoA-bd_prot_sf"}]}, {"database": "PANTHER", "id": "PTHR23310:SF62", "properties": [{"key": "EntryName", "value": "ACYL-COA BINDING PROTEIN 1, ISOFORM A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23310", "properties": [{"key": "EntryName", "value": "ACYL-COA-BINDING PROTEIN, ACBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00887", "properties": [{"key": "EntryName", "value": "ACBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00378", "properties": [{"key": "EntryName", "value": "ECH_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00689", "properties": [{"key": "EntryName", "value": "ACOABINDINGP"}]}, {"database": "SUPFAM", "id": "SSF47027", "properties": [{"key": "EntryName", "value": "Acyl-CoA binding protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52096", "properties": [{"key": "EntryName", "value": "ClpP/crotonase"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00880", "properties": [{"key": "EntryName", "value": "ACB_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51228", "properties": [{"key": "EntryName", "value": "ACB_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAGLAGRFARRWFSGLLGSPLQVPALGLHVRGPAMLASQKDFNNAVSQVKLLKEDPGNEVKLKLYALYKQATEGPCNVPKPGMLDFINKTKWDAWNALGSLSKEAARQNYVDLVSRLSASSESPSPEAPAADRKQPESDSLVVTSEDGITTIRLNRPAKKNALTTQMYHDIIAALQAASKDESAITVLTGGASGEEAACQCKRHKRCGFDPWIRKIP", "length": 217, "molWeight": 23517, "crc64": "9731E65CCBABE0B3", "md5": "05449103B6A9B5E10062D2F1F8E32CB3"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI000059942B"}, "cluster_size": 4, "family": "Bovidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38Z7L6", "uniProtkbId": "A0AB38Z7L6_PAESU", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Paeonia suffruticosa", "commonName": "Tree peony", "synonyms": ["Paeonia moutan"], "taxonId": 45171, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20334.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "Saxifragales", "Paeoniaceae", "Paeonia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20334.1"}], "value": "Protease do-like 1 chloroplastic"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004229"}], "value": "Plastid, chloroplast", "id": "SL-0049"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010541"}], "value": "Belongs to the peptidase S1C family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 2, "modifier": "EXACT"}, "end": {"value": 37, "modifier": "EXACT"}}, "description": "F-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50181"}]}, {"type": "Domain", "location": {"start": {"value": 731, "modifier": "EXACT"}, "end": {"value": 803, "modifier": "EXACT"}}, "description": "PDZ", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50106"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022528"}], "id": "KW-0150", "category": "Cellular component", "name": "Chloroplast"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022801"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022640"}], "id": "KW-0934", "category": "Cellular component", "name": "Plastid"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022670"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20334.1"}], "id": "KW-0645", "category": "Molecular function", "name": "Protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022825"}], "id": "KW-0720", "category": "Molecular function", "name": "Serine protease"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022946"}], "id": "KW-0809", "category": "Domain", "name": "Transit peptide"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-67NUCHPS7RPVN", "citationType": "submission", "authors": ["Zhang Y.", "Gai S."], "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRI20334.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR237919", "properties": [{"key": "ProteinId", "value": "WRI20334.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0009534", "properties": [{"key": "GoTerm", "value": "C:chloroplast thylakoid"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0004252", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0010206", "properties": [{"key": "GoTerm", "value": "P:photosystem II repair"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0006508", "properties": [{"key": "GoTerm", "value": "P:proteolysis"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "CDD", "id": "cd00990", "properties": [{"key": "EntryName", "value": "cpPDZ_AtDEGP1-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.40.10.10:FF:000001", "properties": [{"key": "EntryName", "value": "Periplasmic serine protease DegS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "2.40.10.10:FF:000103", "properties": [{"key": "EntryName", "value": "Protease Do-like 1, chloroplastic"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1280.50", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.30.42.10", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.80.10.10", "properties": [{"key": "EntryName", "value": "Ribonuclease Inhibitor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.40.10.10", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR051201", "properties": [{"key": "EntryName", "value": "Chloro_Bact_Ser_Proteases"}]}, {"database": "InterPro", "id": "IPR039382", "properties": [{"key": "EntryName", "value": "DEGP1/8_PDZ_dom"}]}, {"database": "InterPro", "id": "IPR036047", "properties": [{"key": "EntryName", "value": "F-box-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR001810", "properties": [{"key": "EntryName", "value": "F-box_dom"}]}, {"database": "InterPro", "id": "IPR055357", "properties": [{"key": "EntryName", "value": "LRR_At1g61320_AtMIF1"}]}, {"database": "InterPro", "id": "IPR032675", "properties": [{"key": "EntryName", "value": "LRR_dom_sf"}]}, {"database": "InterPro", "id": "IPR001478", "properties": [{"key": "EntryName", "value": "PDZ"}]}, {"database": "InterPro", "id": "IPR036034", "properties": [{"key": "EntryName", "value": "PDZ_sf"}]}, {"database": "InterPro", "id": "IPR009003", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA"}]}, {"database": "InterPro", "id": "IPR043504", "properties": [{"key": "EntryName", "value": "Peptidase_S1_PA_chymotrypsin"}]}, {"database": "InterPro", "id": "IPR001940", "properties": [{"key": "EntryName", "value": "Peptidase_S1C"}]}, {"database": "PANTHER", "id": "PTHR43343:SF2", "properties": [{"key": "EntryName", "value": "PDZ DOMAIN-CONTAINING PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR43343", "properties": [{"key": "EntryName", "value": "PEPTIDASE S12"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00646", "properties": [{"key": "EntryName", "value": "F-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23622", "properties": [{"key": "EntryName", "value": "LRR_At1g61320_AtMIF1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13180", "properties": [{"key": "EntryName", "value": "PDZ_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13365", "properties": [{"key": "EntryName", "value": "Trypsin_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00834", "properties": [{"key": "EntryName", "value": "PROTEASES2C"}]}, {"database": "SMART", "id": "SM00256", "properties": [{"key": "EntryName", "value": "FBOX"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00228", "properties": [{"key": "EntryName", "value": "PDZ"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81383", "properties": [{"key": "EntryName", "value": "F-box domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50156", "properties": [{"key": "EntryName", "value": "PDZ domain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52047", "properties": [{"key": "EntryName", "value": "RNI-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF50494", "properties": [{"key": "EntryName", "value": "Trypsin-like serine proteases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50181", "properties": [{"key": "EntryName", "value": "FBOX"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50106", "properties": [{"key": "EntryName", "value": "PDZ"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDDRISALPRDVIHHIFSFLSPKDIACLSVLSKPFKSAWTTLPILTFHGREGKQELLNFVDQTLRNRHTQKIGLSELVIDLSSYNLKKVGNLVYRWIRYAIDCNVKELILSVDGKHGWYNLPAHSSLFMAPSITNLILQGHINLVQCGIMNLSLKKLYLSQVRLDDQTANTLISNSPNLEILDLIDCDGLKSLKIVGLVKLTDLCLIVNGDFQRLDIEAIHLKVFKFYGVTEDSVYEMNLSRCYNGNLNLSFSWKTNLVASEAIISLKTESDTNVTPAQYVQITEFLAKYNHCKKVELQSQNVIIPEKERQTLMSPLYNVKHLKILVPGPLKGRDMERLVEGLLWISPHPETLSIALGYLYNVDVTKVLKFKYEKVGDKKDTCFCRSLPIAPLYYQLSPTPQEMAAYSLISTLFTITNPTPTLSHSPNRKRTFFLPKSFSSHKTPILISPVLSLLHRNSHTPDSNNPSPFQKTFLTGTPFSSVLDSLLVLCTSIALSFSLFIADVDSASAFVVTTPRKLQTDELATVRLFQENTPSVVYITNLAVRQDAFTLDVLEVPQGSGSGFVWDKNGHIVTNYHVIRGASDLRVTLADQMTYDAKVVGFDQDKDVAVLRVDAPKDKLRPIPVGISADLLVGQKVYAIGNPFGLDHTLTTGVISGLRREISSAATGRPIQDVIQTDAAINPGNSGGPLLDSSGSLIGINTAIYSPSGASSGVGFSIPVDTVGGIVDQLVKFGKVTRPILGIKFAPDQSVEQLGVSGVLVLDAPANGPAGKAGLLSTKRDAYGRLILGDIITSVNGTKVTNGSDLYRILDQCKVGDKVIVEVLRGDHKEKIPVTLEPKADET", "length": 844, "molWeight": 92694, "crc64": "C82C630F6A505D3C", "md5": "B95C0AA22E8EE9B0402921E1FCCFB225"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 2}, "uniParcId": "UPI00388C20BA"}, "cluster_size": 1, "family": "Paeoniaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LHB4", "uniProtkbId": "A0AAN0LHB4_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65886.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65886.1"}], "value": "UDP-glycosyltransferase"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65886.1"}], "value": "UGT"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009995"}], "value": "Belongs to the UDP-glycosyltransferase family"}], "commentType": "SIMILARITY"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022676"}], "id": "KW-0328", "category": "Molecular function", "name": "Glycosyltransferase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022679"}], "id": "KW-0808", "category": "Molecular function", "name": "Transferase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRV65886.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP145339", "properties": [{"key": "ProteinId", "value": "WRV65886.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0008194", "properties": [{"key": "GoTerm", "value": "F:UDP-glycosyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd03784", "properties": [{"key": "EntryName", "value": "GT1_Gtf-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2000", "properties": [{"key": "EntryName", "value": "Glycogen Phosphorylase B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR050271", "properties": [{"key": "EntryName", "value": "UDP-glycosyltransferase"}]}, {"database": "InterPro", "id": "IPR002213", "properties": [{"key": "EntryName", "value": "UDP_glucos_trans"}]}, {"database": "PANTHER", "id": "PTHR48043", "properties": [{"key": "EntryName", "value": "EG:EG0003.4 PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR48043:SF145", "properties": [{"key": "EntryName", "value": "FI06409P-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00201", "properties": [{"key": "EntryName", "value": "UDPGT"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53756", "properties": [{"key": "EntryName", "value": "UDP-Glycosyltransferase/glycogen phosphorylase"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKLWQKHEFFKIKKKNYQKFWRHFNICVSIAKRILVQNPKHTIYFIVNEPFEKKVKKISPLFQTIRIKQEDEEIFNSILKNPESFKENFYYHGERRYIANINILDSFQKFYQKVEKGFNEIIHNLQPDFILVDSIINLPFTEDKNIPWGMITSANPLLCQDLNNLPPSMSGLSTINDQELIEKYKDLRTDLSLFKNRKIWYEKNNLATSDNFSIVNGSNYINLFTYPKYTSYFNPNNIVGKWFAVNHGILDEKTEKKFQSLSKDFKQEIIKYPGVDLLTPEFLSNSGKLILISLGTMVTLFPDVINNLLEHVKDIPHKFIVSGGISFDKLKLPENCIGAPYLDQQQLYPKVDLVITHGGNNTFCELFYYGVKMILIPHFGDQPDNGKRVEDLKIGVQLDLIDLSLEKLSNAINYVLYNEDIKEKMKIASMMSKDNENFDKFINELDMYLLKKK", "length": 453, "molWeight": 53084, "crc64": "6A5F102DD7D850F5", "md5": "B9CD173059DDDA78E876013229CD9E54"}, "extraAttributes": {"countByCommentType": {"SIMILARITY": 1}, "uniParcId": "UPI0032511CA9"}, "cluster_size": 3, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LJ25", "uniProtkbId": "A0AAN0LJ25_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34088.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34088.1"}], "value": "Muscrinic acethylcholine receptor-like GPCR protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 420, "modifier": "EXACT"}, "end": {"value": 444, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 456, "modifier": "EXACT"}, "end": {"value": 480, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 492, "modifier": "EXACT"}, "end": {"value": 513, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 534, "modifier": "EXACT"}, "end": {"value": 556, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 585, "modifier": "EXACT"}, "end": {"value": 604, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1244, "modifier": "EXACT"}, "end": {"value": 1262, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 434, "modifier": "EXACT"}, "end": {"value": 1302, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}, {"type": "Region", "location": {"start": {"value": 188, "modifier": "EXACT"}, "end": {"value": 209, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 713, "modifier": "EXACT"}, "end": {"value": 759, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 771, "modifier": "EXACT"}, "end": {"value": 900, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1101, "modifier": "EXACT"}, "end": {"value": 1151, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 189, "modifier": "EXACT"}, "end": {"value": 204, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 717, "modifier": "EXACT"}, "end": {"value": 735, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 793, "modifier": "EXACT"}, "end": {"value": 802, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 810, "modifier": "EXACT"}, "end": {"value": 825, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 851, "modifier": "EXACT"}, "end": {"value": 863, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 889, "modifier": "EXACT"}, "end": {"value": 900, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1101, "modifier": "EXACT"}, "end": {"value": 1149, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34088.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155014", "properties": [{"key": "ProteinId", "value": "WRW34088.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0030425", "properties": [{"key": "GoTerm", "value": "C:dendrite"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0045202", "properties": [{"key": "GoTerm", "value": "C:synapse"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0016907", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled acetylcholine receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004993", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled serotonin receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007197", "properties": [{"key": "GoTerm", "value": "P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007187", "properties": [{"key": "GoTerm", "value": "P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "PANTHER", "id": "PTHR24247", "properties": [{"key": "EntryName", "value": "5-HYDROXYTRYPTAMINE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24247:SF191", "properties": [{"key": "EntryName", "value": "MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "SMART", "id": "SM01381", "properties": [{"key": "EntryName", "value": "7TM_GPCR_Srsx"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDDLNKIIRSNDNKLYLQLNNYNKKEKYADKKVNLENKLENVLEKDLEKSYNRFKNKRIKLKDFKENNYKKANFNLKNLKDFSEREFFKKLNETKKKLSKSVQNLSKNNKDKKLSFSYSNLNELNDTNSELLPKDKSNYSYEEISLDFLDLDYNNQLNNQTSINSNTNDTSVFKNSIEDYNFEIKNLDNQSNENETESSSLNSELIRSNNNDKVDNSKIAVDLTDSKNLYLFSSSERLILDLNEENENKTEWSSENESRPFIDKDKNEKNNYTNQFTELFNYNSSDSKFNFLYELDLLEDSGNSLNNIDFYQQKLPSMKLLNDHQQVDDNPTLLSSKKLKINFTANTALFTTMASLTNKMLLKLSAPNNFYLPSQKFNSMDVYSQNSSIFDFSFESNEQFNSTPIFSDAESYNVYRKTAIAVLITIACIITIAGNVLVLVAFYVERNIRQPSNYFICSLAVSDFIIGIISMPFFGVYIVKGKWKLGPKACDLWLATDHTVCLVSIYTVLLITIDRYCSIKIPTKYRSWRTRKKIFILIAITWVVPFLLFFISIFGWEYFIGYRDLAEGECAVQFLKDPVFNTSLIFAYFYVTMVIMFVLYGGIYRTASKMAKKSAAKQNKIMQNLTALSANPITSIIGQTVNQDNCKNQIDNTNLKMKTGNVRAAVAAVVNNSNGTQISFSLDPKKQVELFYTDAAVVLTDLEKQDNCEILNQKTENNTSNNSSNFKTSNISKINANNSDKKCTNSNESENPTLKKENEILDKTYLKSLNSNEHEASNKKLSKKSKTFTSAKINSSETQIQIKNKKENNTHQNKTHQNPSEVSSLSDEEMEQDRSSSPVFDSDEDENENQQESKHMCGQEQKQKFKQQHKHLDIQKKQKTKPSTSSQTVNKSNKKSPLQKFSANNLENKIITTESSTKKSNNFIKYHTQQPNFLIPRSPVFSNDNEFSSTKCNSSDKDFKNSNVSLMTANQALIDESLKQNQENNYSDNYSKSEEIEVNNLNQSSNDTEENIVDEAVKCGFIVVEQRLIQKNVLEEQLIENEKILNKKKQHQLEQHEEIFEKQQKIYIQQIYEQQFGEKCEKFNFNSAISKSQEIKKELEEKKNENKALDKSSPETHIIENLNNEKSEEKKSSSNKSESDEKVELEKKSKSFNSSHNLKRVGFVAKLSKKLHILNSNSLKENFKGQNATSSNSGLINNSANNQSEGTNIITMNTENQTKQQTTIISGLKKKRQKSKSENRARKALRTISFILGAFVICWTPYHVCALIQSFCSKNSSCISHDLFYFSYFLCYANSPINPFCYAMANQQFKKTFYRILKGDFHRT", "length": 1324, "molWeight": 152461, "crc64": "2AA47997335FE17F", "md5": "163DC50543C4E35C90EB10DBDACCACC9"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 6, "Domain": 1, "Region": 4, "Compositional bias": 7}, "uniParcId": "UPI003255F360"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96S2H2", "uniProtkbId": "A0AA96S2H2_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50088.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50088.1"}], "value": "Centromere-associated protein E-like protein"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004245"}], "value": "Cytoplasm, cytoskeleton", "id": "SL-0090"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00283"}], "value": "Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 5, "modifier": "EXACT"}, "end": {"value": 320, "modifier": "EXACT"}}, "description": "Kinesin motor", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50067"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1819, "modifier": "EXACT"}, "end": {"value": 1840, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1923, "modifier": "EXACT"}, "end": {"value": 1942, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 2125, "modifier": "EXACT"}, "end": {"value": 2174, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 2247, "modifier": "EXACT"}, "end": {"value": 2280, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 2411, "modifier": "EXACT"}, "end": {"value": 2467, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 333, "modifier": "EXACT"}, "end": {"value": 383, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 544, "modifier": "EXACT"}, "end": {"value": 1161, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 1197, "modifier": "EXACT"}, "end": {"value": 1810, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Coiled coil", "location": {"start": {"value": 1893, "modifier": "EXACT"}, "end": {"value": 1920, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1825, "modifier": "EXACT"}, "end": {"value": 1834, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1933, "modifier": "EXACT"}, "end": {"value": 1942, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 2125, "modifier": "EXACT"}, "end": {"value": 2135, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 2411, "modifier": "EXACT"}, "end": {"value": 2432, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Binding site", "location": {"start": {"value": 81, "modifier": "EXACT"}, "end": {"value": 88, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30616"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00283"}], "ligand": {"name": "ATP", "id": "ChEBI:CHEBI:30616"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022840"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00283"}], "id": "KW-0067", "category": "Ligand", "name": "ATP-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023212"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023212"}], "id": "KW-0206", "category": "Cellular component", "name": "Cytoskeleton"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023175"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00283"}], "id": "KW-0505", "category": "Molecular function", "name": "Motor protein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022741"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00283"}], "id": "KW-0547", "category": "Ligand", "name": "Nucleotide-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50088.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460165", "properties": [{"key": "ProteinId", "value": "WNS50088.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005856", "properties": [{"key": "GoTerm", "value": "C:cytoskeleton"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005524", "properties": [{"key": "GoTerm", "value": "F:ATP binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "GO", "id": "GO:0008017", "properties": [{"key": "GoTerm", "value": "F:microtubule binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003777", "properties": [{"key": "GoTerm", "value": "F:microtubule motor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007018", "properties": [{"key": "GoTerm", "value": "P:microtubule-based movement"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "3.40.850.10", "properties": [{"key": "EntryName", "value": "Kinesin motor domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR027640", "properties": [{"key": "EntryName", "value": "Kinesin-like_fam"}]}, {"database": "InterPro", "id": "IPR019821", "properties": [{"key": "EntryName", "value": "Kinesin_motor_CS"}]}, {"database": "InterPro", "id": "IPR001752", "properties": [{"key": "EntryName", "value": "Kinesin_motor_dom"}]}, {"database": "InterPro", "id": "IPR036961", "properties": [{"key": "EntryName", "value": "Kinesin_motor_dom_sf"}]}, {"database": "InterPro", "id": "IPR027417", "properties": [{"key": "EntryName", "value": "P-loop_NTPase"}]}, {"database": "PANTHER", "id": "PTHR47968", "properties": [{"key": "EntryName", "value": "CENTROMERE PROTEIN E"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47968:SF75", "properties": [{"key": "EntryName", "value": "CENTROMERE-ASSOCIATED PROTEIN E"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00225", "properties": [{"key": "EntryName", "value": "Kinesin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00380", "properties": [{"key": "EntryName", "value": "KINESINHEAVY"}]}, {"database": "SMART", "id": "SM00129", "properties": [{"key": "EntryName", "value": "KISc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF52540", "properties": [{"key": "EntryName", "value": "P-loop containing nucleoside triphosphate hydrolases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00411", "properties": [{"key": "EntryName", "value": "KINESIN_MOTOR_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50067", "properties": [{"key": "EntryName", "value": "KINESIN_MOTOR_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MEQSKIQVGVRLRPQSEREKSAGLQQSMTAIDNSVTCTAGTFLFDKVFSENSANQDVFDEMCRPIILSFLEGINGTIFAYGQTASGKTHTMMGSSGRDGEPGVIPIALATIFEYINEHSSSRDFILRCSYLEIYNEELTDLLDKRAGKKLTIKEDSQRNLTVQGLTEHSIVDCNEAVKYIWEGQEVRSVAETAMNERSSRSHAIYRLTLESKAVDGDMVKVSVLNLVDLAGNEKAHNTNDPQRFKEGVRINLSLLHLGIVIAKLSDGESGSYIFRDSKLTRILQNSLGGNAKTAVLCTISPFVSEETMNTLKFAGRAMRIENKPKVNELPTSIDAVLRKLAAMEEENRMLRLRLSEEGETPEKQSLLESLQARETEKQDLEQTVAALKKFIYKEPSTAKDKDKALRRQTVGPMTLGTSRSPVEFSASIGVNNLSFRQAKKRRQSFFTPGLLNSSESFACCDEIEEDGESPKVHFNMDRIQYIQESPNSFSDNSSHRGTQTDFVFVGECAQELGTKLTFPTDLVPGVDAGAGVHCSVQTEQDQLVIQWQDKCSELEKENAVLVEECSSLKSTVSGLREDSSATVEQLQQKLLSMENDAESLKNDLKSKMEEMIDTYEQKLLHAEQDKTSYQNEKNALQTECAALKSQLKECIGTHDRKQLQTQQECSELEKENAVLVEECSKLKSTVSGLREDSSATVEQLQQKALDYEEVCLQLKQDYEESLTRRNQLEAECSELEKENAVRVEECSKLKSTVSGLREDSSATVEQLQQKALDYEEVCLQLKQDYEESLTRRNQLEAECSELEKENAVLVEECSKLKSTVSGLREDSSATVEQLQQKALDYEEVCLQLKQDYEESLTRRNQLEAECSELEKENAVLVEECSKLKSTVSGLREDSSATVEQLQQKALDYEEVCLQLKQDYEESLTRRNQLEAELSQFSEAHSLLSTEKQALLSQIEYEQQQHMQILSEAEQQCSELEKENAVRVEECSKLKSTVSGLREDSSATVEQLQQKALDHEQTCLQLKLNYEESLTRRNQLEAELSQLLKAHSLLSTEKQVLLSQIEDEQKRHKRALSEAELQNEFVVNEKEVQLEDAVDMLRQSEESVQALKEQCAALEASCTQFQEQKSILAKELLILKQQTGDVSCLEDQNESLLGKVEELSTLLSQSQTHNEELEMVYSKTATSREKLKEVCATQDQLVIQWQDKCSELEKENAVLLEECSKLKSTVCGLREDSSATVEQLQQKALDYEEVCLQLKQDYKESLTRRNQLEAELSQFSEAHSLLNKEKQALLSQIEYEQQQHMQILSEAEQQCSELEKENAVMVEECSKLKSTVSGLREDSSATVEQLQQKALDYEEVCLQLKQDYEESLTRRNQLEAELSQFSEAHSRLSTEKQALLSQIEDEKQQHKRALSEAEPQCSELEKENAVLLEECSKLKSTVCGLREDSSATVEQLQQKALDYEEVCLQLKQDYEESLTRRNQLEAELSQFSEAHNLLSTEKQVLLSQIEYEQQQHMQILSEAEQQCSELEKENAVMVEECSKLKSTVSGLREDSSATVEQLQQKALDYEEVCLQPKQDYEESLTRRNQLEAELSQFSEAHNLLSTEKQVLLSQIEYEQQQHMQILSEAEQQCSELEKENAVLVEECSKLKSTVSGLREDSSATVEQLQQKTLDYEEICLQLKQDYEESLTRRNQLEAELSQLSEAHSLCSTEKQVLLSQIEDEQLQHKQTLSEAELQLSVSLAKIEELGVESATSQQSNQDLKVNLTEVDQQKVKLEQDKTSCSQDLDDLASHLQELKEQKSKLQADLRAIFKQVSTIQKRRYTRSDESDLSSENEEDSGLKEPANLKAAILAKVDDQEKMLRHFRRDRNEMQKHTIFYNKELDDMDDKLEKQAAIVKSVNKSLSVANEQVKQLTDKNLHLKKELTSASIQQQPCKPNDHDQGKTQELRKLQEKLRRAAADKKISESQSEAFRQKLSGLEGTVVELQEKLKKEAVSESQRDAFRQKLSNSEGAVVELKKKLKKEAAEKEISESQRDASKQKLSDLEKTVEELQEKLKKEAAKKIFDTRRDASAQDLSGLDGTVEELRGKLKKAAAEKKISETQKDAFRQKMNDLEETVEDLRAELKKIVTTKKSREPSKDASAQVLSVLEESVKKPQTEEGSTQPAATPDPVGHGCGLSMELRNYQLQMELGQAKKQIRQMRSGKSNAREVEDLEKKLLAMKKHCTSLEAALAESDKKPLQDVNPKHCENLEPALAESDKKPLQDVNPKHCTSLEPTLAESDKKPLLDVNQKHCTSLESTLAESDKKPLQDVNPKHCENLEPALAESDKKPLQDVNPKHCTSLEPALAESDKKPLQDVNPSQLPLHKLWTATHRPTRDLRSANKIPIPLRPFNPSGVPATTTINHPLIVKKKNSTIVPPSTTHPLASVKENSTIGQNPEKPKSGPPVSLTGGMNFKWNDAGHGSKETCTTQ", "length": 2467, "molWeight": 278664, "crc64": "6181F9B019394DDB", "md5": "153692E708DF1E8C7ADE630B4B2ACE28"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Region": 6, "Coiled coil": 4, "Compositional bias": 4, "Binding site": 1}, "uniParcId": "UPI002B29F80A"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HBQ3", "uniProtkbId": "A0AA96HBQ3_9MOLL", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Macellomenia sp", "taxonId": 3077341, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25259.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Aplacophora", "Solenogastres", "Pholidoskepia", "Macellomeniidae", "Macellomenia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25259.1"}], "value": "Hypoxia-inducible factor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 15, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Domain", "location": {"start": {"value": 95, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 238, "modifier": "EXACT"}, "end": {"value": 284, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 518, "modifier": "EXACT"}, "end": {"value": 583, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 522, "modifier": "EXACT"}, "end": {"value": 538, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 542, "modifier": "EXACT"}, "end": {"value": 555, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 570, "modifier": "EXACT"}, "end": {"value": 583, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25259.1"}], "value": "Mace1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25259.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354994", "properties": [{"key": "ProteinId", "value": "WNN25259.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "InterPro", "id": "IPR013655", "properties": [{"key": "EntryName", "value": "PAS_fold_3"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08447", "properties": [{"key": "EntryName", "value": "PAS_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MDDHKSKTKRRYSVKRREKAKEAARTRRDIENELYQSMISLLPLESNIIKRNYCQALRISIAFIQLCHIKQLNEQSKHHLQPIFKREAIDAEPSILEALHGFFIIVSSCGNVTFVTDTVSHSLGIPQGVILGSNLYEYVHESDVKELRSILGQEDGHGGSSSSVRFLCRLRCTLSSKGSVSNIKSAPYRVIQFIGRHVSLPSGTYVMALCQPLIHPSNIEIPLEHGTFLTRHKASMTFTYCDDRMKDLVGFTRDDVLGKSVYEYHHTADHHIITKAHQDLLSKGESVSEAYRFLAKHGGYVSIISHSTLIYHDFTQQPECVVSIYFVLSGVQCPELILSHVQVPPVKSKLPLTNSQTQNKTATIDKECDKREITKPAIVEMTKVSSSKPGGQMKENFTITRSVTSMEALLGERGPTLPKGRDMKLWNKLPKYGIFGGMKMPIGATESVLMQTTVAPLTNTRFNLPNKLNLNQPMASPPSLHKHDIEMTSPLKSVAQPSAINPLPNVEQQLDQEMTSLSPLNHKGDHIAIPTTDKESTHHHNGTLSPSLSAHNSPTSPLPLESSADMRVESPSSVYPTSSSSSQFNCSSPDLVMSQFDPDVSLCDLQTLLTRNARRAPKVAKRQARCSVLKQLLLHGTTRMHGDDYSDKSKASLSQVTSRIKTVYSPLKPVDYDVYTPTQDTLLYGQQLLDALD", "length": 693, "molWeight": 77175, "crc64": "F070549DCB52677B", "md5": "05AB2D1B34949DFAF2BE484C6C342756"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 2, "Compositional bias": 4}, "uniParcId": "UPI002B2952EC"}, "cluster_size": 1, "family": "Macellomeniidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1E8", "uniProtkbId": "A0AAU7P1E8_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30750.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30750.1"}], "value": "Low density lipoprotein receptor"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30750.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 40, "modifier": "EXACT"}, "end": {"value": 40, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30750.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30750.1"}], "id": "KW-0449", "category": "PTM", "name": "Lipoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30750.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30749.1"}], "value": "13", "type": "STRAIN"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30750.1"}], "value": "14", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30750.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892405", "properties": [{"key": "ProteinId", "value": "XBS30749.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "EMBL", "id": "PP892406", "properties": [{"key": "ProteinId", "value": "XBS30750.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "PeptideAtlas", "id": "A0AAU7P1E8", "properties": [{"key": "Description", "value": "-"}]}], "sequence": {"value": "SVSGGQMQRKKRVPVPRREMHLLQVGLRWQRCARMALCPR", "length": 40, "molWeight": 4717, "crc64": "CE7F0F98EEB3120E", "md5": "918F2CB47692DD400AB171457AC99B55"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D36362"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU8HLY7", "uniProtkbId": "A0AAU8HLY7_MACNP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Macrobrachium nipponense", "commonName": "Oriental river shrimp", "synonyms": ["Palaemon nipponensis"], "taxonId": 159736, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI10632.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Caridea", "Palaemonoidea", "Palaemonidae", "Macrobrachium"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012759"}], "value": "ubiquitinyl hydrolase 1"}, "ecNumbers": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00012759"}], "value": "3.4.19.12"}]}, "flag": "Fragment"}, "comments": [{"commentType": "CATALYTIC ACTIVITY", "reaction": {"name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "ecNumber": "3.4.19.12", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00000707"}]}}], "features": [{"type": "Domain", "location": {"start": {"value": 572, "modifier": "EXACT"}, "end": {"value": 840, "modifier": "EXACT"}}, "description": "USP", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50235"}]}, {"type": "Region", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 104, "modifier": "EXACT"}, "end": {"value": 188, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 208, "modifier": "EXACT"}, "end": {"value": 232, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 247, "modifier": "EXACT"}, "end": {"value": 498, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 540, "modifier": "EXACT"}, "end": {"value": 563, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 37, "modifier": "EXACT"}, "end": {"value": 79, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 104, "modifier": "EXACT"}, "end": {"value": 118, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 122, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 148, "modifier": "EXACT"}, "end": {"value": 157, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 212, "modifier": "EXACT"}, "end": {"value": 221, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 223, "modifier": "EXACT"}, "end": {"value": 232, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 316, "modifier": "EXACT"}, "end": {"value": 331, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 343, "modifier": "EXACT"}, "end": {"value": 353, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 356, "modifier": "EXACT"}, "end": {"value": 366, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 377, "modifier": "EXACT"}, "end": {"value": 393, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 405, "modifier": "EXACT"}, "end": {"value": 416, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 417, "modifier": "EXACT"}, "end": {"value": 452, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 552, "modifier": "EXACT"}, "end": {"value": 563, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 840, "modifier": "EXACT"}, "end": {"value": 840, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI10632.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI10632.1"}], "id": "KW-0378", "category": "Molecular function", "name": "Hydrolase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-10O13T5OTP3F4", "citationType": "submission", "authors": ["Gao Z."], "publicationDate": "JUL-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XCI10632.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP977265", "properties": [{"key": "ProteinId", "value": "XCI10632.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0004843", "properties": [{"key": "GoTerm", "value": "F:cysteine-type deubiquitinase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0016579", "properties": [{"key": "GoTerm", "value": "P:protein deubiquitination"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd02674", "properties": [{"key": "EntryName", "value": "Peptidase_C19R"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.90.70.10", "properties": [{"key": "EntryName", "value": "Cysteine proteinases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR038765", "properties": [{"key": "EntryName", "value": "Papain-like_cys_pep_sf"}]}, {"database": "InterPro", "id": "IPR001394", "properties": [{"key": "EntryName", "value": "Peptidase_C19_UCH"}]}, {"database": "InterPro", "id": "IPR050185", "properties": [{"key": "EntryName", "value": "Ub_carboxyl-term_hydrolase"}]}, {"database": "InterPro", "id": "IPR028889", "properties": [{"key": "EntryName", "value": "USP"}]}, {"database": "PANTHER", "id": "PTHR21646", "properties": [{"key": "EntryName", "value": "UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21646:SF23", "properties": [{"key": "EntryName", "value": "UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00443", "properties": [{"key": "EntryName", "value": "UCH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF54001", "properties": [{"key": "EntryName", "value": "Cysteine proteinases"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50235", "properties": [{"key": "EntryName", "value": "USP_3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MLQENQRNAEGQATIMDYVKSYVTVCLSNMPVPPSSPSVGTSRYPSYTSYSSSYRSPSSSSYSGRTTSLDRSPYLSTYGSSYSSNYSTSTYASKYSRPPIPSYSVATDTYRSSRSLRQSPVRPTYSRLSSDSSLESTLSPSRYSTSRYSRDKRDVSTSRDSGYGSRLSSRDRSVDIINGNGVDTSHFGPSPSSYACNYRWEYREKDNKAETGGSNDTTEQNGEAEKIRVTDRIRNFETRSSAAKEIGGGLLAGRESSSTGRERGYSPAKDSSSVVPRRRMIPLTLVDIPKRSSSTSRKSPSARDDDDDRNNNSGSNERRPSVTELCRKYDTNHNVTNGVAKQDDDDEDEDDDRSDGSACSGGPAAAADDDAAVGTVETVTLTLKTRPRTSSTSRADRRESPLVSRVSSPATGSRLDSPTRSRVESPARSRFDTSFKESPVRNRFESPLRNRLDSSVGRPESPCDRDGGRTSPYVNGTLDKPKVRAKTESSSLEGSPLGRSRYRQERAWERIAARLANELSTITLKTYCIARARNVFYRDEGSPPRRHQTTISSNSCSSSAGGTSLSENNGLVGLRNIGNTCFMNSVTQCLSNTRCLLEYLVQDGYSSDINTTISTMKGDLIRAFANLLTDMWNEGSDSSRALNTGPFKSQIQRFAPAFSGYQQHDAQEFLRKLLEGLHEDVNRVILKPKPITEDIDDELDDNQKAMESWKRYLRYDDSKIVDMFVGQLKSCLQCSVCGHCSVTFDPFWDLSLPIPSKSGQVRLSQCLDLFTKEEVLDGDERPTCSKCKERRKMTKSFSIQKFPKVLVLRTNINIKVVICIFLRVLASGRSTSTSWGYTMR", "length": 840, "molWeight": 93310, "crc64": "D43F4CDDCE29AAC9", "md5": "5C50A942F129BDE26DB8C717B6AAD127"}, "extraAttributes": {"countByCommentType": {"CATALYTIC ACTIVITY": 1}, "countByFeatureType": {"Domain": 1, "Region": 5, "Compositional bias": 13, "Non-terminal residue": 1}, "uniParcId": "UPI0035D26F9E"}, "cluster_size": 1, "family": "Palaemonidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QK17", "uniProtkbId": "A0AAU0QK17_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56517.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56517.1"}], "value": "Ionotropic receptor"}}]}, "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56517.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56517.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56517.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970317", "properties": [{"key": "ProteinId", "value": "WPO56517.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSNSHEALATLVAISKGQAAIAAAAFTVLSDPPPKNFTIKVILSSQVKHLASNDTTADMSNSHEALATLVAISKGQAAIAAAAFTVLSDPPPGINYTLAVSTQPYCFMIARPRELSRALLFLLPFTTDVSINILGSIY", "length": 138, "molWeight": 14459, "crc64": "C79762331896F949", "md5": "21F0FAA8CF781165E0BA3F0E0440FDCE"}, "extraAttributes": {"uniParcId": "UPI00308A3123"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0LM70", "uniProtkbId": "A0AAN0LM70_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34068.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34068.1"}], "value": "G protein-coupled receptor"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010663"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "value": "Belongs to the G-protein coupled receptor 1 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 63, "modifier": "EXACT"}, "end": {"value": 88, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 100, "modifier": "EXACT"}, "end": {"value": 125, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 145, "modifier": "EXACT"}, "end": {"value": 165, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 177, "modifier": "EXACT"}, "end": {"value": 199, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 229, "modifier": "EXACT"}, "end": {"value": 250, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 283, "modifier": "EXACT"}, "end": {"value": 301, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 321, "modifier": "EXACT"}, "end": {"value": 343, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 340, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 1 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50262"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023040"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0297", "category": "Molecular function", "name": "G-protein coupled receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000688"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34068.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154994", "properties": [{"key": "ProteinId", "value": "WRW34068.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0043005", "properties": [{"key": "GoTerm", "value": "C:neuron projection"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0042923", "properties": [{"key": "GoTerm", "value": "F:neuropeptide binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0004983", "properties": [{"key": "GoTerm", "value": "F:neuropeptide Y receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd15203", "properties": [{"key": "EntryName", "value": "7tmA_NPYR-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000276", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn"}]}, {"database": "InterPro", "id": "IPR017452", "properties": [{"key": "EntryName", "value": "GPCR_Rhodpsn_7TM"}]}, {"database": "InterPro", "id": "IPR000611", "properties": [{"key": "EntryName", "value": "NPY_rcpt"}]}, {"database": "PANTHER", "id": "PTHR24235:SF29", "properties": [{"key": "EntryName", "value": "GH23382P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24235", "properties": [{"key": "EntryName", "value": "NEUROPEPTIDE Y RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00001", "properties": [{"key": "EntryName", "value": "7tm_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00237", "properties": [{"key": "EntryName", "value": "GPCRRHODOPSN"}]}, {"database": "PRINTS", "id": "PR01012", "properties": [{"key": "EntryName", "value": "NRPEPTIDEYR"}]}, {"database": "SMART", "id": "SM01381", "properties": [{"key": "EntryName", "value": "7TM_GPCR_Srsx"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00237", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50262", "properties": [{"key": "EntryName", "value": "G_PROTEIN_RECEP_F1_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFTEDETRSELINFKEESQSYKQNIIYNNISTKQLKIGNLTQNLLQNVMNDTVYFEILPSLKVFFYCAYSIIFFVGLFGNILVCYVVYSNKNMNNVTYYFITNLAMSDIFLCLFSVPITPIYLLSFEYWPFGSLFCHLLPFSQGVSVYISSFTLMSIAIERYFLVIHPFNKKMTNNVCFGVICIIWISGIILILPYSIFMELKPYDTNDENNSKWFCDESWPHETSRRTFSTCTSIIQFIVPFIIIAFCYSEVCSRLNERAKSNLGNARKQEYERERSKRTNYMLILIVIIFVICWLPLNAHNLIVDFFPSVNNWPYIKVFSLLAHVTAMCSTCCNPFVYAWLDKAFRKEFKNILPCFNLSKFKPTKAKKNETNDRVKKSKNKKIISFLSLTCKTKDCFTKSNRFNKQTVIVFKNDTHQISIKDENILNDLSKLNHHGNVNIENINDKQNESLISKKNDIFESNMNKEKNFLIIENEDNFCFSNEDVISENTIIDLNNRISIKRNCEANTV", "length": 511, "molWeight": 59764, "crc64": "BAECB1BA09D92B09", "md5": "40627A12F6843A94BE5B09A12D6450E4"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1}, "uniParcId": "UPI00325429B6"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0Z2M5", "uniProtkbId": "A0AAF0Z2M5_AGATE", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Agave tequilana", "commonName": "Tequila agave", "taxonId": 386106, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49292.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Liliopsida", "Asparagales", "Asparagaceae", "Agavoideae", "Agave"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49292.1"}], "value": "SPL-like protein 7"}}]}, "features": [{"type": "Domain", "location": {"start": {"value": 3, "modifier": "EXACT"}, "end": {"value": 80, "modifier": "EXACT"}}, "description": "SBP-type", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51141"}]}, {"type": "Region", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 80, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022771"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00470"}], "id": "KW-0863", "category": "Domain", "name": "Zinc-finger"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1T5UBM1TQD9AG", "citationType": "submission", "authors": ["Hernandez-Soriano L.", "Galvez-Sandre L.", "Avila De Dios E.", "Simpson J."], "title": "How to awaken a sleeping giant: antagonistic expression of flowering locus T homologs and elements of the age related pathway are associated with the flowering transition in Agave tequilana.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49292.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR751389", "properties": [{"key": "ProteinId", "value": "WPD49292.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0008270", "properties": [{"key": "GoTerm", "value": "F:zinc ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "4.10.1100.10", "properties": [{"key": "EntryName", "value": "Transcription factor, SBP-box domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR044817", "properties": [{"key": "EntryName", "value": "SBP-like"}]}, {"database": "InterPro", "id": "IPR004333", "properties": [{"key": "EntryName", "value": "SBP_dom"}]}, {"database": "InterPro", "id": "IPR036893", "properties": [{"key": "EntryName", "value": "SBP_sf"}]}, {"database": "PANTHER", "id": "PTHR31251", "properties": [{"key": "EntryName", "value": "SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31251:SF108", "properties": [{"key": "EntryName", "value": "SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 7"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03110", "properties": [{"key": "EntryName", "value": "SBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF103612", "properties": [{"key": "EntryName", "value": "SBT domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51141", "properties": [{"key": "EntryName", "value": "ZF_SBP"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAVVRCQVPGCEADIRELKGYHRRHRVCLRCANAPSVVIDGEDRRYCQQCGKFHTLPDFDEGKRSCRRKLERHNRKRRRRPIDLVSIEEKEKGPQADLSTEATYDEEPKEGNGVGCEAVLISKGNTREILLDSDDGHGSPICSLPGSQNMQSNNIMSFAVPVEAHIDEEKDNSKSALSSTICDNRSAYSSLIMMQYMIIVSNRPHII", "length": 207, "molWeight": 23331, "crc64": "B790430F136EBD7D", "md5": "B8B6FBB3027E80BFC0FCA729C2970241"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Compositional bias": 1}, "uniParcId": "UPI002B30CB39"}, "cluster_size": 1, "family": "Asparagaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39JAP9", "uniProtkbId": "A0AB39JAP9_9CHLO", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Dunaliella parva", "taxonId": 3048, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN84332.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Chlorophyta", "core chlorophytes", "Chlorophyceae", "CS clade", "Chlamydomonadales", "Dunaliellaceae", "Dunaliella"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003426"}], "value": "Malic enzyme"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN84332.1"}], "value": "ME"}}], "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "Mg(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-3"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:18420"}}, {"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-3"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}], "note": {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-3"}], "value": "Divalent metal cations. Prefers magnesium or manganese."}]}}, {"commentType": "COFACTOR", "cofactors": [{"name": "Mn(2+)", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001936"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:29035"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008785"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003426"}], "value": "Belongs to the malic enzymes family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 365, "modifier": "EXACT"}, "end": {"value": 384, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 48, "modifier": "EXACT"}, "end": {"value": 235, "modifier": "EXACT"}}, "description": "Malic enzyme N-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM01274"}]}, {"type": "Active site", "location": {"start": {"value": 71, "modifier": "EXACT"}, "end": {"value": 71, "modifier": "EXACT"}}, "description": "Proton donor", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-1"}]}, {"type": "Active site", "location": {"start": {"value": 149, "modifier": "EXACT"}, "end": {"value": 149, "modifier": "EXACT"}}, "description": "Proton acceptor", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-1"}]}, {"type": "Binding site", "location": {"start": {"value": 131, "modifier": "EXACT"}, "end": {"value": 131, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:15589"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-2"}], "ligand": {"name": "(S)-malate", "id": "ChEBI:CHEBI:15589"}}, {"type": "Binding site", "location": {"start": {"value": 220, "modifier": "EXACT"}, "end": {"value": 220, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:60240"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-3"}], "ligand": {"name": "a divalent metal cation", "id": "ChEBI:CHEBI:60240"}}, {"type": "Binding site", "location": {"start": {"value": 221, "modifier": "EXACT"}, "end": {"value": 221, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:60240"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-3"}], "ligand": {"name": "a divalent metal cation", "id": "ChEBI:CHEBI:60240"}}, {"type": "Binding site", "location": {"start": {"value": 244, "modifier": "EXACT"}, "end": {"value": 244, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:60240"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-3"}], "ligand": {"name": "a divalent metal cation", "id": "ChEBI:CHEBI:60240"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR000106-3"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU003426"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-FGBL1J1G6M2IJ", "citationType": "submission", "authors": ["Shang C."], "title": "Combined Effects of Nitrogen Limitation and Overexpression of Malic Enzyme Gene on Lipid Accumulation in Dunaliella parva.", "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN84332.1"}], "value": "FACHB-815", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN84332.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ120576", "properties": [{"key": "ProteinId", "value": "XDN84332.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0004473", "properties": [{"key": "GoTerm", "value": "F:malate dehydrogenase (decarboxylating) (NADP+) activity"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0051287", "properties": [{"key": "GoTerm", "value": "F:NAD binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0006108", "properties": [{"key": "GoTerm", "value": "P:malate metabolic process"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "Gene3D", "id": "3.40.50.10380", "properties": [{"key": "EntryName", "value": "Malic enzyme, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.720", "properties": [{"key": "EntryName", "value": "NAD(P)-binding Rossmann-like Domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR046346", "properties": [{"key": "EntryName", "value": "Aminoacid_DH-like_N_sf"}]}, {"database": "InterPro", "id": "IPR015884", "properties": [{"key": "EntryName", "value": "Malic_enzyme_CS"}]}, {"database": "InterPro", "id": "IPR012301", "properties": [{"key": "EntryName", "value": "Malic_N_dom"}]}, {"database": "InterPro", "id": "IPR037062", "properties": [{"key": "EntryName", "value": "Malic_N_dom_sf"}]}, {"database": "InterPro", "id": "IPR012302", "properties": [{"key": "EntryName", "value": "Malic_NAD-bd"}]}, {"database": "InterPro", "id": "IPR001891", "properties": [{"key": "EntryName", "value": "Malic_OxRdtase"}]}, {"database": "InterPro", "id": "IPR036291", "properties": [{"key": "EntryName", "value": "NAD(P)-bd_dom_sf"}]}, {"database": "NCBIfam", "id": "NF010052", "properties": [{"key": "EntryName", "value": "PRK13529.1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23406:SF68", "properties": [{"key": "EntryName", "value": "MALIC ENZYME"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23406", "properties": [{"key": "EntryName", "value": "MALIC ENZYME-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00390", "properties": [{"key": "EntryName", "value": "malic"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03949", "properties": [{"key": "EntryName", "value": "Malic_M"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PIRSF", "id": "PIRSF000106", "properties": [{"key": "EntryName", "value": "ME"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00072", "properties": [{"key": "EntryName", "value": "MALOXRDTASE"}]}, {"database": "SMART", "id": "SM01274", "properties": [{"key": "EntryName", "value": "malic"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53223", "properties": [{"key": "EntryName", "value": "Aminoacid dehydrogenase-like, N-terminal domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF51735", "properties": [{"key": "EntryName", "value": "NAD(P)-binding Rossmann-fold domains"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00331", "properties": [{"key": "EntryName", "value": "MALIC_ENZYMES"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MGAAPSTQPAGCPGCDDASIAAAALQQLDAVPEAHGGIEKYMYLRMLHEKKPDEFYRLLTTETERVLPFIYTPTVGEACRRYFELAARKKEPKLRPRGIFLTLEDRGRVLEKLKAWPQQNVKVIVVTDGERILGLGDLGAGGMGISEGKITLYTVAAGVDPAHCLPVCLDVGTNNKDLLQDAHYKGLKRTRATGQEYDSFVEEFMDAVSQWQPHVLIQFEDFGNTNAFRLLERYRPSHCTFNDDIQGTAAITLAALLSALRAIEFDKYRDADTGQGAMYISDGSLGAGQLLEGKQVLFLGAGEAGTGIGELIAYCVHRRTGCSMQEARKTCHFVDSKGLVILSSVAAARALCCVGLFVVPLFTYYASNYFSIFAVLSIVEGRLFV", "length": 385, "molWeight": 42111, "crc64": "AB269C3317853321", "md5": "DDAEDDB20FB47759F6DCF2BD66FD4003"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 2, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 1, "Active site": 2, "Binding site": 4}, "uniParcId": "UPI00388C3180"}, "cluster_size": 1, "family": "Dunaliellaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7N0", "uniProtkbId": "A0AAN0N7N0_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34057.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34057.1"}], "value": "Glutamate [NMDA] receptor subunit 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00034100"}], "value": "Postsynaptic cell membrane", "id": "SL-0219"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 1093, "modifier": "EXACT"}, "end": {"value": 1111, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1132, "modifier": "EXACT"}, "end": {"value": 1151, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1163, "modifier": "EXACT"}, "end": {"value": 1189, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1351, "modifier": "EXACT"}, "end": {"value": 1372, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 967, "modifier": "EXACT"}, "end": {"value": 1328, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00079"}]}, {"type": "Domain", "location": {"start": {"value": 975, "modifier": "EXACT"}, "end": {"value": 1037, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor L-glutamate and glycine-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00918"}]}, {"type": "Binding site", "location": {"start": {"value": 1046, "modifier": "EXACT"}, "end": {"value": 1046, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 1048, "modifier": "EXACT"}, "end": {"value": 1048, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 1053, "modifier": "EXACT"}, "end": {"value": 1053, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 1265, "modifier": "EXACT"}, "end": {"value": 1265, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Site", "location": {"start": {"value": 1196, "modifier": "EXACT"}, "end": {"value": 1196, "modifier": "EXACT"}}, "description": "Crucial to convey clamshell closure to channel opening", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Site", "location": {"start": {"value": 1226, "modifier": "EXACT"}, "end": {"value": 1226, "modifier": "EXACT"}}, "description": "Interaction with the cone snail toxin Con-ikot-ikot", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 1277, "modifier": "EXACT"}, "end": {"value": 1333, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023257"}], "id": "KW-0628", "category": "Cellular component", "name": "Postsynaptic cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34057.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023018"}], "id": "KW-0770", "category": "Cellular component", "name": "Synapse"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022833"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34057.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP154983", "properties": [{"key": "ProteinId", "value": "WRW34057.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0045211", "properties": [{"key": "GoTerm", "value": "C:postsynaptic membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0038023", "properties": [{"key": "GoTerm", "value": "F:signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "FunFam", "id": "2.60.40.10:FF:000437", "properties": [{"key": "EntryName", "value": "Beat-IIIc, isoform A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000010", "properties": [{"key": "EntryName", "value": "glutamate receptor ionotropic, NMDA 1 isoform X1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.40.190.10:FF:000009", "properties": [{"key": "EntryName", "value": "Putative glutamate receptor ionotropic NMDA 2B"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.50.2300", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "2.60.40.10", "properties": [{"key": "EntryName", "value": "Immunoglobulins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR001828", "properties": [{"key": "EntryName", "value": "ANF_lig-bd_rcpt"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR013783", "properties": [{"key": "EntryName", "value": "Ig-like_fold"}]}, {"database": "InterPro", "id": "IPR001508", "properties": [{"key": "EntryName", "value": "Iono_Glu_rcpt_met"}]}, {"database": "InterPro", "id": "IPR015683", "properties": [{"key": "EntryName", "value": "Ionotropic_Glu_rcpt"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR013099", "properties": [{"key": "EntryName", "value": "K_chnl_dom"}]}, {"database": "InterPro", "id": "IPR028082", "properties": [{"key": "EntryName", "value": "Peripla_BP_I"}]}, {"database": "PANTHER", "id": "PTHR18966", "properties": [{"key": "EntryName", "value": "IONOTROPIC GLUTAMATE RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01094", "properties": [{"key": "EntryName", "value": "ANF_receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF07885", "properties": [{"key": "EntryName", "value": "Ion_trans_2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00177", "properties": [{"key": "EntryName", "value": "NMDARECEPTOR"}]}, {"database": "SMART", "id": "SM00918", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00079", "properties": [{"key": "EntryName", "value": "PBPe"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53822", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like I"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81324", "properties": [{"key": "EntryName", "value": "Voltage-gated potassium channels"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MSNNVKKWSNMISGSYSVRIRQLHVPMAIYKGSPIQLHCEFELQHSMLYSVKYYKNYIEFYRYLPSHVPSAQTYNLKGTYVDLNKSNASHVIFSKTDLDSQGTYSCEVSTEAPDFSTVKAEKQMKVYILPEDPLRIEGTEPTYEMHNLINLTCISGASFPAQNLVWYINDEKASTKNLIYYSNSNKPTNALLQVSKLGLRLTANDAKFRKGSLKLVCQASLTLIYEYETSQTLSGGTQPRNKLLTSSGVDEHYSNLNNDNYSLKPNYLLTSSNNSLNHEQPIKQIMNIHSNGQDENSNVITWKNDLLLMKVSRDAPLITGGKERYRVGSILNINCSATADAHLSWYIKNKKANETQLVYYSNVNPCCSILGLKFRMQNRHFQMQELKLTCKATHFKKIVSYNKQLLIRTIGASANSKLKFEGESRNKKLWRIQSINNSIFFEPSLIINSQDFHTDFQTNDYPPFTNYDSYLTAPQYAAGSKRSPNNHGKNLNSNKFNVENPKIFNVGAVLDKDELVQDFIQVIDSIYYEPNVLPPNVNLYPFNLILNRNPIQAVQDVCDKLIKNQVYAVIVKDGNNPESLAVTQTCNFYNIPVIGISNRESSMSDKHMHSAYMRMVPPYSHQVNVWIEVLKHLKYKNVVFIHSADYDGRTSFTKFQALADKNHIEILSVIEYEPLMTNISNELEQIDHELKSRVYLLYTNKEDAQSIFVDVNRLNLTQNGYVWLISEQALEATNVPNGALGIQAFNSTNESGYIRDALYIIGLAIRELYKKENITSLPPSYCGEIGKNNWKLGDKLFNILRKQVLLFGKTGRVAFDGKGDRIDADYEIINYIYNRKVIVGNYAFSQSKMQMQLWLNENSIIWPGFQNKKPVGYYLPNKLKIVTIAEKPFLWSRPLDYQTIDNLRQHVNDLSKKKKFPVINAFNKTLNVLKTYNSKNSQQNNQNLNLFNQQIIFDENLIEQEFCNSNELLCTKYDEVSMKNNFYCCKGYCIDFLKTLATRLNISFSLYQVTDDQYGSFEIDKKTNKKKWNGLIGEIVMKKADLIVAPLTINPERSLFIDFSKPFKYQGITIISKQQLKSRSSLASFMEPFEDSLWIFVMISVHVVALVLYLLDRFSPFGRYRLPNCDIIEEDALNLSSAIWFAWGVLLNSGIGESSPRSFGGRLLGMIWAGFAIIIIASYTGNLAAFLVLNRPETALSGINDSRFRNPTENYTYSTVKNSAIINYFKRQVELSNIYNHIIKNKQLNTVEAGIEAVRNNEINAFIWDSARLEYEASQDCELSIASEQFGKSGYGIGLSKNSFWTEKVNEAILSMHESGYMERLDNEWILNPNPDCVNKDTLGMTLGLKNMAGVFILVGMGIVGGIGLILIEWIYKNKQSKSQKQLEKARYAADKWKKYIQRKKKLQLNLKQTREKQVSNSQSKIGKIKRAEFANSRTNEEFQSVCTDTRVLSNEATTIKSSLFNLPELHQEVINYNTSLDRNLNWQNSSQGSKDFLINETIVKHPLYSNSNKNQVSYCFDKTSKNFPSDQQPSNISYQKIIDNNYPEQIITHNKYASLNQLEQENVGILKHEKKKTKVYSHPIRFNQLKHQQAINEMNNYETSYHSVYDESYCDTNRSHAQSTIGSFISLPRNSQTNLQLIKPPHVLSNQKRTKNYFPYGYHN", "length": 1661, "molWeight": 190545, "crc64": "475A6DB933777CBC", "md5": "4E81158C60CE61307F5C592A194AFF60"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 4, "Domain": 2, "Binding site": 4, "Site": 2, "Disulfide bond": 1}, "uniParcId": "UPI0032536395"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7P1A4", "uniProtkbId": "A0AAU7P1A4_HUMAN", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30733.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30733.1"}], "value": "Low density lipoprotein receptor"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30733.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 129, "modifier": "EXACT"}, "end": {"value": 129, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30733.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30733.1"}], "id": "KW-0449", "category": "PTM", "name": "Lipoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30733.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-BH4MP61BBH1GJ", "citationType": "submission", "authors": ["Zahid A.", "Batool A.", "Khan M.A."], "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30733.1"}], "value": "9", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBS30733.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP892389", "properties": [{"key": "ProteinId", "value": "XBS30733.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "YKLDYAYEASLHSGPTAPACGVGELGLAFPFHLPLALGNALGGAMYNTLCHSALISSCKRPFPASQCWGSQHRHVRQEPHLGSHLASASCHAQVLASRYRASNCGFQTWVLGGEYQGFLNCTWRLGTVA", "length": 129, "molWeight": 13878, "crc64": "26CAA8EC5FBE9BBD", "md5": "B5DB795869FEB0B23FE6A5B41881A224"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI0035D39BC4"}, "cluster_size": 5, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAX7FLT5", "uniProtkbId": "A0AAX7FLT5_VIBCL", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Vibrio cholerae", "taxonId": 666, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8QJK"}], "lineage": ["Bacteria", "Pseudomonadati", "Pseudomonadota", "Gammaproteobacteria", "Vibrionales", "Vibrionaceae", "Vibrio"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8QJK"}], "value": "Csx23"}}]}, "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8QJK"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}], "references": [{"referenceNumber": 1, "citation": {"id": "38471818", "citationType": "journal article", "authors": ["Gruschow S.", "McQuarrie S.", "Ackermann K.", "McMahon S.", "Bode B.E.", "Gloster T.M.", "White M.F."], "citationCrossReferences": [{"database": "PubMed", "id": "38471818"}, {"database": "DOI", "id": "10.1093/nar/gkae167"}], "title": "CRISPR antiphage defence mediated by the cyclic nucleotide-binding membrane protein Csx23.", "publicationDate": "2024", "journal": "Nucleic Acids Res.", "firstPage": "2761", "lastPage": "2775", "volume": "52"}, "referencePositions": ["X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS)"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8QJK"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8QJK", "properties": [{"key": "Method", "value": "X-ray"}, {"key": "Resolution", "value": "1.76 A"}, {"key": "Chains", "value": "A=1-96"}]}, {"database": "SMR", "id": "A0AAX7FLT5", "properties": [{"key": "Description", "value": "-"}]}], "sequence": {"value": "GANAMDEITVVLKSPNGKNIKCPPMPRKDFSRAEVLGYIGMCSGAQRFEIASLKTPKFGENLLKIIKSKGSQSFIVDCTDEEIDQFSAETKSGSNA", "length": 96, "molWeight": 10387, "crc64": "013991DB3413ECF6", "md5": "9C0E7CF22E0A9DC687DCF5F34F8B2439"}, "extraAttributes": {"uniParcId": "UPI0034E057B8"}, "cluster_size": 1, "family": "Vibrionaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BH95", "uniProtkbId": "A0AAQ5BH95_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519305.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519305.1"}], "value": "Tropomyosin 1"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519305.1"}], "value": "TPM1"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004245"}], "value": "Cytoplasm, cytoskeleton", "id": "SL-0090"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00009036"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU004515"}], "value": "Belongs to the tropomyosin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 38, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 117, "modifier": "EXACT"}, "end": {"value": 136, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 38, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023203"}], "id": "KW-0009", "category": "Molecular function", "name": "Actin-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023054"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023212"}], "id": "KW-0963", "category": "Cellular component", "name": "Cytoplasm"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023212"}], "id": "KW-0206", "category": "Cellular component", "name": "Cytoskeleton"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023179"}], "id": "KW-0514", "category": "Molecular function", "name": "Muscle protein"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BH95"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BH95"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519305.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519305.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16572171", "citationType": "journal article", "authors": ["Zody M.C.", "Garber M.", "Sharpe T.", "Young S.K.", "Rowen L.", "O'Neill K.", "Whittaker C.A.", "Kamal M.", "Chang J.L.", "Cuomo C.A.", "Dewar K.", "FitzGerald M.G.", "Kodira C.D.", "Madan A.", "Qin S.", "Yang X.", "Abbasi N.", "Abouelleil A.", "Arachchi H.M.", "Baradarani L.", "Birditt B.", "Bloom S.", "Bloom T.", "Borowsky M.L.", "Burke J.", "Butler J.", "Cook A.", "DeArellano K.", "DeCaprio D.", "Dorris L.III.", "Dors M.", "Eichler E.E.", "Engels R.", "Fahey J.", "Fleetwood P.", "Friedman C.", "Gearin G.", "Hall J.L.", "Hensley G.", "Johnson E.", "Jones C.", "Kamat A.", "Kaur A.", "Locke D.P.", "Madan A.", "Munson G.", "Jaffe D.B.", "Lui A.", "Macdonald P.", "Mauceli E.", "Naylor J.W.", "Nesbitt R.", "Nicol R.", "O'Leary S.B.", "Ratcliffe A.", "Rounsley S.", "She X.", "Sneddon K.M.", "Stewart S.", "Sougnez C.", "Stone S.M.", "Topham K.", "Vincent D.", "Wang S.", "Zimmer A.R.", "Birren B.W.", "Hood L.", "Lander E.S.", "Nusbaum C."], "citationCrossReferences": [{"database": "PubMed", "id": "16572171"}, {"database": "DOI", "id": "10.1038/nature04601"}], "title": "Analysis of the DNA sequence and duplication history of human chromosome 15.", "publicationDate": "2006", "journal": "Nature", "firstPage": "671", "lastPage": "675", "volume": "440"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519305.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519305.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC079328", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "SMR", "id": "A0AAQ5BH95", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENST00000714015.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519305.1"}, {"key": "GeneId", "value": "ENSG00000140416.26"}]}, {"database": "HGNC", "id": "HGNC:12010", "properties": [{"key": "GeneName", "value": "TPM1"}]}, {"database": "OpenTargets", "id": "ENSG00000140416", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT01030000234542", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 15"}]}, {"database": "GO", "id": "GO:0005862", "properties": [{"key": "GoTerm", "value": "C:muscle thin filament tropomyosin"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "GO", "id": "GO:0003779", "properties": [{"key": "GoTerm", "value": "F:actin binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "FunFam", "id": "1.20.5.1160:FF:000013", "properties": [{"key": "EntryName", "value": "Tropomyosin 1 (alpha)"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.20.5.170:FF:000001", "properties": [{"key": "EntryName", "value": "Tropomyosin alpha-1 chain isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.20.5.340:FF:000001", "properties": [{"key": "EntryName", "value": "Tropomyosin alpha-1 chain isoform 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.5.170", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.20.5.340", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR000533", "properties": [{"key": "EntryName", "value": "Tropomyosin"}]}, {"database": "PANTHER", "id": "PTHR19269", "properties": [{"key": "EntryName", "value": "TROPOMYOSIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00261", "properties": [{"key": "EntryName", "value": "Tropomyosin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00194", "properties": [{"key": "EntryName", "value": "TROPOMYOSIN"}]}, {"database": "SUPFAM", "id": "SSF57997", "properties": [{"key": "EntryName", "value": "Tropomyosin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00326", "properties": [{"key": "EntryName", "value": "TROPOMYOSIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEEPIFFQV", "length": 265, "molWeight": 30577, "crc64": "B349DF4E8547B04C", "md5": "B29D6A88C2CEA0CA573DB1E7296FF4D8"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Region": 2, "Compositional bias": 1}, "uniParcId": "UPI0032D11984"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6PB13", "uniProtkbId": "A0AAU6PB13_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Comana monomorpha", "taxonId": 1555636, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20540.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Zygaenoidea", "Limacodidae", "Comana"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20540.1"}], "value": "Venom peptide"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 142, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043402929"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7EP05DIF44JED", "citationType": "journal article", "authors": ["Goudarzi M.H.", "Robinson S.D.", "Cardoso F.C.", "Mitchell M.L.", "Cook L.G.", "King G.F.", "Walker A.A."], "title": "Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).", "publicationDate": "2024", "journal": "Sci. Rep.", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20540.1"}], "value": "U_LCTX_20_Cm8", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXB20540.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP480809", "properties": [{"key": "ProteinId", "value": "WXB20540.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "1.10.2080.10", "properties": [{"key": "EntryName", "value": "Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR005055", "properties": [{"key": "EntryName", "value": "A10/PebIII"}]}, {"database": "InterPro", "id": "IPR036682", "properties": [{"key": "EntryName", "value": "OS_D_A10/PebIII_sf"}]}, {"database": "PANTHER", "id": "PTHR11257", "properties": [{"key": "EntryName", "value": "CHEMOSENSORY PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11257:SF12", "properties": [{"key": "EntryName", "value": "EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03392", "properties": [{"key": "EntryName", "value": "OS-D"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF100910", "properties": [{"key": "EntryName", "value": "Chemosensory protein Csp2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKTFIVVCLAVLAVATAKYTDKYDNTDVDEIMSNCRLMVPYAKCLLGDKKKCTKEGLELKEHVVDALQNECSECTDVQKEKTKRVIGCIYVKNQAIYKKVAALYDPKGDYEKKYQKELQEAAAAGDFENIPECDFDTERAKE", "length": 142, "molWeight": 16108, "crc64": "00977441CCE7AD22", "md5": "709D8E5F7AD81B74BF6888C6669BFC33"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D37571"}, "cluster_size": 1, "family": "Limacodidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAA9TXM2", "uniProtkbId": "A0AAA9TXM2_BOVIN", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Bos taurus", "commonName": "Bovine", "taxonId": 9913, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000102226.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000009136"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Laurasiatheria", "Artiodactyla", "Ruminantia", "Pecora", "Bovidae", "Bovinae", "Bos"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "value": "Galectin"}}}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000102226.1"}], "value": "LOC787905"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00055823"}], "value": "Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions"}], "commentType": "FUNCTION"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 142, "modifier": "EXACT"}, "end": {"value": 164, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 147, "modifier": "EXACT"}}, "description": "Galectin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51304"}]}, {"type": "Domain", "location": {"start": {"value": 355, "modifier": "EXACT"}, "end": {"value": 484, "modifier": "EXACT"}}, "description": "Galectin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51304"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022734"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU102079"}], "id": "KW-0430", "category": "Ligand", "name": "Lectin"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAA9TXM2"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000009136"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DV49K6FT0EEMD", "citationType": "submission", "authors": ["Rosen B.D.", "Bickhart D.M.", "Koren S.", "Schnabel R.D.", "Hall R.", "Zimin A.", "Dreischer C.", "Schultheiss S.", "Schroeder S.G.", "Elsik C.G.", "Couldrey C.", "Liu G.E.", "Van Tassell C.P.", "Phillippy A.M.", "Smith T.P.L.", "Medrano J.F."], "title": "ARS-UCD1.2.", "publicationDate": "MAR-2018", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000102226.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000009136"}], "value": "Hereford", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000102226.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000009136"}]}, {"referenceNumber": 2, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000102226.1"}], "value": "Hereford", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSBTAP00000102226.1"}]}], "uniProtKBCrossReferences": [{"database": "Ensembl", "id": "ENSBTAT00000111776.1", "properties": [{"key": "ProteinId", "value": "ENSBTAP00000102226.1"}, {"key": "GeneId", "value": "ENSBTAG00000016312.7"}]}, {"database": "GeneTree", "id": "ENSGT00940000160378", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000009136", "properties": [{"key": "Component", "value": "Chromosome 18"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0030246", "properties": [{"key": "GoTerm", "value": "F:carbohydrate binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-UniRule"}]}, {"database": "CDD", "id": "cd00070", "properties": [{"key": "EntryName", "value": "GLECT"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "2.60.120.200:FF:000124", "properties": [{"key": "EntryName", "value": "Galectin-4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "2.60.120.200", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "InterPro", "id": "IPR013320", "properties": [{"key": "EntryName", "value": "ConA-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR044156", "properties": [{"key": "EntryName", "value": "Galectin-like"}]}, {"database": "InterPro", "id": "IPR001079", "properties": [{"key": "EntryName", "value": "Galectin_CRD"}]}, {"database": "PANTHER", "id": "PTHR11346", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11346:SF32", "properties": [{"key": "EntryName", "value": "GALECTIN-4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00337", "properties": [{"key": "EntryName", "value": "Gal-bind_lectin"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "SMART", "id": "SM00908", "properties": [{"key": "EntryName", "value": "Gal-bind_lectin"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SMART", "id": "SM00276", "properties": [{"key": "EntryName", "value": "GLECT"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF49899", "properties": [{"key": "EntryName", "value": "Concanavalin A-like lectins/glucanases"}, {"key": "MatchStatus", "value": "3"}]}, {"database": "PROSITE", "id": "PS51304", "properties": [{"key": "EntryName", "value": "GALECTIN"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MGNCPLECGQGYSPPCPARFFVNFEVGQGQGADVAFHFNPRFDGWDKVVLNSKQNGSWGQEERKMSMPFRKGAAFELVFMVMTEHFKVRAVGAGPPRPAPPSLLFFLSSCLPACLPFFPYSFPPAVSFFFFPLSLSPPSSLFSFLFLLSCLLANSFSFNFFFILELFKYKFSHLFFLFPFLHRGDPSDMFRVYHLAPLCSCEIEICVSRFRRIQLFATPWTAARQAPLSLKFSRATRKAQTHAKGSTELWETLLSWARADSCQFQVVVNGTPFHEFKHRIPLQMVTHLHVDGDLMLQSINFIGGQPPSNQMPMPAQAYPMPMSAQAYPSPGQYYQQQSRLPTMEGPPAFNPPVPFNGRLQGGLIVRRTIIIKGYIPPTAKSFVINFKVGSSGDVALHINPRMTEGAVVRNSFLNGSWGSEERKVSYNPFGPGQFFDLSVRCGADRFKVYANGKHLFDFSHRLSAFQRVDLVEIHGDVTLSYVQI", "length": 484, "molWeight": 54523, "crc64": "5736A281AD06C22B", "md5": "7C5498FEB4C919E2536FC6313AACFA97"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1}, "countByFeatureType": {"Transmembrane": 1, "Domain": 2}, "uniParcId": "UPI002B4FB8C2"}, "cluster_size": 1, "family": "Bovidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96KE74", "uniProtkbId": "A0AA96KE74_9MOLL", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Helluoherpia aegiri", "taxonId": 1541971, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25252.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Aplacophora", "Solenogastres", "Pholidoskepia", "Dondersiidae", "Helluoherpia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25252.1"}], "value": "Hypoxia-inducible factor 1"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 15, "modifier": "EXACT"}, "end": {"value": 67, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Domain", "location": {"start": {"value": 82, "modifier": "EXACT"}, "end": {"value": 145, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 224, "modifier": "EXACT"}, "end": {"value": 275, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 338, "modifier": "EXACT"}, "end": {"value": 384, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 438, "modifier": "EXACT"}, "end": {"value": 475, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 548, "modifier": "EXACT"}, "end": {"value": 568, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 628, "modifier": "EXACT"}, "end": {"value": 648, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 14, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 15, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 349, "modifier": "EXACT"}, "end": {"value": 374, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 445, "modifier": "EXACT"}, "end": {"value": 466, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 638, "modifier": "EXACT"}, "end": {"value": 648, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25252.1"}], "value": "Hellu1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25252.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354987", "properties": [{"key": "ProteinId", "value": "WNN25252.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "InterPro", "id": "IPR013655", "properties": [{"key": "EntryName", "value": "PAS_fold_3"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF08447", "properties": [{"key": "EntryName", "value": "PAS_3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MEPPKPKAKRRISDKRRLQAKEAARTRRDTQSEVYTSLISMLPLHSMADKPNHCHALRLSVAYIHLCHIKRSKSKALVKCEAQSTDPSIWDALHGFFIIISSEGKVIFVTENVASYLGIPQVEMLGSSVYDYLHECDIKQVRGILSTKSTSPCHISFLCRVKCPLTHRGTTTNIKSAPYRVMQFIGRQLCVVSGIYVTALCQPITHPATMDIPLDMGTFLCCHDPSMIFTFCDDRMRDLVGFSRDEVLGKSVYEYHHTGDHHILIKAHTDLFSKGQSVSDEYRFMVKHGGYVVMISQSTVIYHNTSQQPRWVVSIHFVLSGVQCRNLILSHVQVPPTNQLTNRLPDNQLVKDTKKEEETLTKHDLPKSSKHPADKASPCAADKPVPSTTIELKKLSHRAPSLPNGRDIKLWSRIPKYGIFGAMKLPVGATESVIMRNDSEDDELSPAPTLTTTALSPAPTPNNNASDLDLSPPHKLNNHDILPMFKTNLSSMPSITIRNDHKLPSFHRNNQTRSTFPNRDLHLSSHDLYLTTSDIDVLKNDPKIPQMSNNLSPPLSKITPQSGELSSSDLHFSTPDLDISTDLPFDLKPTAPVSSELSHAQDQTLHKEIKPGCTILKSLLLRGTEQKLTTHNHHASNESDQYMPSRPRNMSVTKLKNPACPRLSPHDYARYAPTDHDTLLYGQLLLDALDT", "length": 691, "molWeight": 77378, "crc64": "9F5B44282FBBDCB9", "md5": "ADA7C865E86B6D00F6468C6FD509972C"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 5, "Compositional bias": 5}, "uniParcId": "UPI002B2E097C"}, "cluster_size": 1, "family": "Dondersiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MI55", "uniProtkbId": "A0AA96MI55_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50086.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50086.1"}], "value": "Uncharacterized protein 21"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 20, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 21, "modifier": "EXACT"}, "end": {"value": 214, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041744014"}, {"type": "Region", "location": {"start": {"value": 45, "modifier": "EXACT"}, "end": {"value": 85, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 97, "modifier": "EXACT"}, "end": {"value": 131, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50086.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460163", "properties": [{"key": "ProteinId", "value": "WNS50086.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR008160", "properties": [{"key": "EntryName", "value": "Collagen"}]}, {"database": "InterPro", "id": "IPR050938", "properties": [{"key": "EntryName", "value": "Collagen_Structural_Proteins"}]}, {"database": "PANTHER", "id": "PTHR37456:SF6", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR37456", "properties": [{"key": "EntryName", "value": "SI:CH211-266K2.1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01391", "properties": [{"key": "EntryName", "value": "Collagen"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MNTALAIVGIVIGVVAFAAAQDDLQCIENPTGEVSLNVAVRGIPGQQGPQGIKGDVGSRGQKGQNGDIGVQGTKGQQGVVGPGGPVGAKGEVGQQGVRGMKGSSGPIGPKGIVGSHGRQGDIGATGPRGNPGRAGFPGPKGLLGSPGDLLDSAQIQSLTETVVSSTAPKIQATVMQSITEVEAKVEMLYQTLREEIMSEVQALKSRIGNLTANA", "length": 214, "molWeight": 21424, "crc64": "B9B264B1D527F2AD", "md5": "0A5C9851E137900D4DFD13CFD77673CB"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Region": 2}, "uniParcId": "UPI002B29866A"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF1BVS1", "uniProtkbId": "A0AAF1BVS1_HIRNI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hirudo nipponia", "commonName": "Korean blood-sucking leech", "taxonId": 42736, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49280.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Hirudinea", "Hirudinida", "Hirudiniformes", "Hirudinidae", "Hirudo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49280.1"}], "value": "Uncharacterized protein"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 116, "modifier": "EXACT"}, "end": {"value": 116, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49280.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-ANPA6HQVADV17", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49280.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR759986", "properties": [{"key": "ProteinId", "value": "WPD49280.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MERQLPTNMPAKDLWSSTKMNITRAKSTRRKVTKVMMIIMTMVTRSTTREKSTKMSITRRVIITRRVMMIITRRVTMITMTTNTRKITMTTNTRNITRRITMTTNTRKITMTTNTM", "length": 116, "molWeight": 13698, "crc64": "DE25108DD6EBD2F6", "md5": "08B27585D0027F3F92212ADBF9D41FEF"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI002B300D81"}, "cluster_size": 1, "family": "Hirudinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0Z2L5", "uniProtkbId": "A0AAF0Z2L5_HIRNI", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hirudo nipponia", "commonName": "Korean blood-sucking leech", "taxonId": 42736, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49275.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Hirudinea", "Hirudinida", "Hirudiniformes", "Hirudinidae", "Hirudo"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49275.1"}], "value": "Antistasin-like factor E"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008768"}], "value": "Belongs to the protease inhibitor I15 (antistasin) family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Domain", "location": {"start": {"value": 42, "modifier": "EXACT"}, "end": {"value": 68, "modifier": "EXACT"}}, "description": "Antistasin-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51252"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49275.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 108, "modifier": "EXACT"}, "end": {"value": 108, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49275.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022690"}], "id": "KW-0646", "category": "Molecular function", "name": "Protease inhibitor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022900"}], "id": "KW-0722", "category": "Molecular function", "name": "Serine protease inhibitor"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-ANPA6HQVADV17", "citationType": "submission", "authors": ["Lee C.-J."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPD49275.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR759981", "properties": [{"key": "ProteinId", "value": "WPD49275.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004867", "properties": [{"key": "GoTerm", "value": "F:serine-type endopeptidase inhibitor activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.10.22.10", "properties": [{"key": "EntryName", "value": "Antistasin, domain 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR004094", "properties": [{"key": "EntryName", "value": "Antistasin-like"}]}, {"database": "InterPro", "id": "IPR011061", "properties": [{"key": "EntryName", "value": "Hirudin/antistatin"}]}, {"database": "Pfam", "id": "PF02822", "properties": [{"key": "EntryName", "value": "Antistasin"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF57262", "properties": [{"key": "EntryName", "value": "Leech antihemostatic proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51252", "properties": [{"key": "EntryName", "value": "ANTISTASIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MYCDFWAKDEKGCEICQCEELCQNHTCPKGTLCSSVTNRCDCEDFNCPPSYCPHGFETDENECEVCICKQPCVDCSTTTTTKKPGVLDRVKNWFKGKWGKFKKWGKIW", "length": 108, "molWeight": 12454, "crc64": "6810D515D5CDC76D", "md5": "12E42DDBF2A8153C7CA3B632FB8C055C"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B29BED6"}, "cluster_size": 1, "family": "Hirudinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MLW2", "uniProtkbId": "A0AA96MLW2_THEEQ", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-03-27", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 1, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Theileria equi", "commonName": "Babesia equi", "taxonId": 5872, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50668.1"}], "lineage": ["Eukaryota", "Sar", "Alveolata", "Apicomplexa", "Aconoidasida", "Piroplasmida", "Theileriidae", "Theileria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50668.1"}], "value": "Rhoptry neck protein 5"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50668.1"}], "value": "RON5"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50668.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 478, "modifier": "EXACT"}, "end": {"value": 478, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50668.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9F4UQC03819O4", "citationType": "journal article", "authors": ["Lu X.", "Wang S.", "Chen L.", "Liu M.", "Liu Y.", "Zhu H.", "Jiang B.", "Du S.", "Bayin C.", "Liu D.", "Zhang W."], "title": "Cloning and prokaryotic expression of Theileria equi rhoptry neck protein 5 gene.", "publicationDate": "2023", "journal": "Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi", "firstPage": "497", "lastPage": "501", "volume": "41"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50668.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP777492", "properties": [{"key": "ProteinId", "value": "WNS50668.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "KPAIPSPIIQYITVFVGLWAKGASGDFSMSDINMDRVRKTFFLSYVSNGKSLADMATNIIMDNCKVGNHALHLGCISKISSNNKCKQIYVSLKSNKLKKVLKMLEATFHDPLDIIRLASDTARRCLAQKKQPRPRQSMKRSKPYKYFPLAKKTIKVPHYMDRLMLHSEFSHRIHCYKAQKRLVKEMIKSLSSAVSEDSARKIISTVFSSYRSIEIKQVGMANSSYRLICPFTYDAPEELRNIHQLNIIKYVISKAVSKARFSPERKRLLTSLQSQPHKLYPTIQMEPLADLPGCVLVGTRKYNGVSYSGGYAPLEKIAYPDNVVVKPGEGRLVYDGSGFVPGLMALRETVNVESISVRFEGGYNKYYYNMTDGTQVDERNFAIDSPDFIVKSHVLTTANALIKLGFDMGRIIWCGYKHGWVADFVLSEVVGDTDVPVFNGRYWLLSRELRVEDLVGPDMKIKDGDEIKMENIDKYNIR", "length": 478, "molWeight": 54233, "crc64": "FB22C4E51A1B34FE", "md5": "DD08CB17AF64603F11EC17A7DCF362A5"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 2}, "uniParcId": "UPI002B323A07"}, "cluster_size": 1, "family": "Theileriidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N6H9", "uniProtkbId": "A0AAN0N6H9_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34077.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34077.1"}], "value": "Ionotropic receptor 93a"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00008685"}], "value": "Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family"}], "commentType": "SIMILARITY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00007369"}], "value": "Belongs to the vasopressin/oxytocin family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 19, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 20, "modifier": "EXACT"}, "end": {"value": 1239, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042983358"}, {"type": "Transmembrane", "location": {"start": {"value": 766, "modifier": "EXACT"}, "end": {"value": 783, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1030, "modifier": "EXACT"}, "end": {"value": 1050, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 634, "modifier": "EXACT"}, "end": {"value": 749, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor L-glutamate and glycine-binding", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF10613"}]}, {"type": "Domain", "location": {"start": {"value": 763, "modifier": "EXACT"}, "end": {"value": 1035, "modifier": "EXACT"}}, "description": "Ionotropic glutamate receptor C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00060"}]}, {"type": "Binding site", "location": {"start": {"value": 722, "modifier": "EXACT"}, "end": {"value": 722, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Binding site", "location": {"start": {"value": 727, "modifier": "EXACT"}, "end": {"value": 727, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29985"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-1"}], "ligand": {"name": "L-glutamate", "id": "ChEBI:CHEBI:29985"}}, {"type": "Site", "location": {"start": {"value": 864, "modifier": "EXACT"}, "end": {"value": 864, "modifier": "EXACT"}}, "description": "Crucial to convey clamshell closure to channel opening", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Site", "location": {"start": {"value": 892, "modifier": "EXACT"}, "end": {"value": 892, "modifier": "EXACT"}}, "description": "Interaction with the cone snail toxin Con-ikot-ikot", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-2"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 950, "modifier": "EXACT"}, "end": {"value": 1007, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR601508-3"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023180"}], "id": "KW-0325", "category": "PTM", "name": "Glycoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023303"}], "id": "KW-0407", "category": "Molecular function", "name": "Ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023065"}], "id": "KW-0406", "category": "Biological process", "name": "Ion transport"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023286"}], "id": "KW-1071", "category": "Molecular function", "name": "Ligand-gated ion channel"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34077.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022448"}], "id": "KW-0813", "category": "Biological process", "name": "Transport"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34077.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155003", "properties": [{"key": "ProteinId", "value": "WRW34077.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0015276", "properties": [{"key": "GoTerm", "value": "F:ligand-gated monoatomic ion channel activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005185", "properties": [{"key": "GoTerm", "value": "F:neurohypophyseal hormone activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0038023", "properties": [{"key": "GoTerm", "value": "F:signaling receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0050906", "properties": [{"key": "GoTerm", "value": "P:detection of stimulus involved in sensory perception"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-ARBA"}]}, {"database": "FunFam", "id": "1.10.287.70:FF:000143", "properties": [{"key": "EntryName", "value": "Probable glutamate receptor"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.287.70", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.190.10", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR019594", "properties": [{"key": "EntryName", "value": "Glu/Gly-bd"}]}, {"database": "InterPro", "id": "IPR052192", "properties": [{"key": "EntryName", "value": "Insect_Ionotropic_Sensory_Rcpt"}]}, {"database": "InterPro", "id": "IPR001508", "properties": [{"key": "EntryName", "value": "Iono_Glu_rcpt_met"}]}, {"database": "InterPro", "id": "IPR001320", "properties": [{"key": "EntryName", "value": "Iontro_rcpt_C"}]}, {"database": "InterPro", "id": "IPR036387", "properties": [{"key": "EntryName", "value": "Neurhyp_horm_dom_sf"}]}, {"database": "InterPro", "id": "IPR022423", "properties": [{"key": "EntryName", "value": "Neurohypophysial_hormone_CS"}]}, {"database": "PANTHER", "id": "PTHR42643", "properties": [{"key": "EntryName", "value": "IONOTROPIC RECEPTOR 20A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR42643:SF24", "properties": [{"key": "EntryName", "value": "IONOTROPIC RECEPTOR 60A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00060", "properties": [{"key": "EntryName", "value": "Lig_chan"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF10613", "properties": [{"key": "EntryName", "value": "Lig_chan-Glu_bd"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00177", "properties": [{"key": "EntryName", "value": "NMDARECEPTOR"}]}, {"database": "SUPFAM", "id": "SSF49606", "properties": [{"key": "EntryName", "value": "Neurophysin II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF53850", "properties": [{"key": "EntryName", "value": "Periplasmic binding protein-like II"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81324", "properties": [{"key": "EntryName", "value": "Voltage-gated potassium channels"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00264", "properties": [{"key": "EntryName", "value": "NEUROHYPOPHYS_HORM"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNFVLFLLGFLLFFSFTDSCFITNCPPGGKRSIVKKQKNFFKQYLSCETMTFVDQSQVNELDFLLPTVCKMENLSSINCKILKPRCGPKLNGFCNSSNMCCENDNCFEDKNCYDLMREHDKKLLSCIQKNEFNPFLIQPDFQKELSISHSLILDNLKHINDTNLINLNYKFIEDYEKYSQFEIEFCSEYTLIISALSCYENKDLYKKIQEFCKSTLVMSLISPTCERPTVQQGIAFPIIKSENENYISLLIDLKSNLLYKWKDILMVYDDQLDDFVINSIIYSVETINEPGVEKSKITKLPLYSQYNKQDIEKKSLDNVFSYIKENDSSNNILIGTAKIINDFIIKAYEQNLLVNPRKWIVIYTDYFELDLFLSKIISSSGITIVHREFKNEVCEPRVKGCQFKLLIETFHQALNKVIDNNEYNFNNHLKLKTKNRMVSEMTIYLDSINALKSNQNNFKKSLDLKSNNINDELNNELRKSLYCGICDYFLVKSFERKNQKDKIKRKNIIRNLNPDNWVERLTVWKHSERIFYNEKNRHPVNLDKESIKLLNYRLNLRPLEKNPSITKSLADIKDESLEKLNNIYGVHKKKIVKRSVDYHEVKIETRASWQPFKGLLQVSNDPVLMNTGSLSGKHLRIGIVSQTPIINVEIDSTGGCIVNGSTYELINVLREQLNFTYEWVCSKKMNEEGIGYYDDQKQTWNGLLGMIAKKKIDLAANGIYKTKQRVRSKIFTYTIPYDEEVIKVLVKKTPENDEWLFLTPFTYDTWYAVLLSVVLVGPLLYWVNKSSKYYVYYNENDGERLFKLGNCIWYTFGAIVQQGGDNLPNAISGRLLIAFWWLFEIVTIATYSGNLVALLTFPKIIQPIENVEDLLSYHWTMDWAIGKGTQIEEVLKTLKYGQLTKLKPEMNYLDFEKNREKIFEKVASGSLGYIMSEHEARYWISKKYNEQNWCGMFVAKEPIYRAPLHLVLSKDQPEELMKVLNKEIYYCTRSGLTIYWKRNYEVLEDDCMYTLIVHAGDVKKISYIHMIGSFYLLKVGLALSFVVLVLEYLYHLIIQRGNLKFLFNRDKFKLNNFSDDNMTINYLNNLKQTSQINFKNLPYIPGRDTLYPNYLNEKKIGFWTKFINFLCCKSRIISSRIDSADERRQFFDSNLNKYSSNVFTYYSTGNQLKIDEAVMRSWANLQKIPTVNQYNLSPNFQPNFQFRPKVNNNIYNSQYSTVYSNLVPNYNLKKDYNSFIYRK", "length": 1239, "molWeight": 145358, "crc64": "FE32409CD5387410", "md5": "AC10F561DC5ABF639E859FBD911B9831"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1, "SIMILARITY": 2}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Transmembrane": 2, "Domain": 2, "Binding site": 2, "Site": 2, "Disulfide bond": 1}, "uniParcId": "UPI003244A811"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QL82", "uniProtkbId": "A0AAU0QL82_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56514.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56514.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 27, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56514.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 100, "modifier": "EXACT"}, "end": {"value": 100, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56514.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56514.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56514.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56514.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970407", "properties": [{"key": "ProteinId", "value": "WPO56514.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "SVFNQTGYIVLFVILVAHEIGHFYAICETLNDIHKALYNTSDDNQSIDTGEINQNKHRTDNVAIPNKYEEKKHAKVQNMLRFCIKHHQYLMRYHDEIREL", "length": 100, "molWeight": 11844, "crc64": "4E44303574E63E4D", "md5": "F8B7B5DD1FFBBC4CBD18F88678FA9582"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 1, "Non-terminal residue": 2}, "uniParcId": "UPI003086BDA5"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0T3R7", "uniProtkbId": "A0AAF0T3R7_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2024-10-02", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenuipotamon panxiense", "taxonId": 2841827, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59340.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59340.1"}], "value": "Ceramide synthase 5-like protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59340.1"}], "value": "scaffold2065983"}}], "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004760"}], "value": "Lipid metabolism; sphingolipid metabolism"}], "commentType": "PATHWAY"}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004991"}], "value": "Sphingolipid metabolism"}], "commentType": "PATHWAY"}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 58, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 79, "modifier": "EXACT"}, "end": {"value": 102, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 122, "modifier": "EXACT"}, "end": {"value": 144, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "TLC", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50922"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59340.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 173, "modifier": "EXACT"}, "end": {"value": 173, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59340.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00205"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00205"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59340.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59340.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59340.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59340.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515451", "properties": [{"key": "ProteinId", "value": "WMS59340.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0050291", "properties": [{"key": "GoTerm", "value": "F:sphingosine N-acyltransferase activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046513", "properties": [{"key": "GoTerm", "value": "P:ceramide biosynthetic process"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR016439", "properties": [{"key": "EntryName", "value": "Lag1/Lac1-like"}]}, {"database": "InterPro", "id": "IPR006634", "properties": [{"key": "EntryName", "value": "TLC-dom"}]}, {"database": "PANTHER", "id": "PTHR12560:SF0", "properties": [{"key": "EntryName", "value": "LD18904P"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR12560", "properties": [{"key": "EntryName", "value": "LONGEVITY ASSURANCE FACTOR 1 LAG1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF03798", "properties": [{"key": "EntryName", "value": "TRAM_LAG1_CLN8"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00724", "properties": [{"key": "EntryName", "value": "TLC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50922", "properties": [{"key": "EntryName", "value": "TLC"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "YYMVSLGYYWSMTITHFCQYRRKDSSQLFVHHLLTILLISFSWVVNFVRIGTLVLVVHECGDIPMLLAKICKLCGLQRVMDGFFLMFLVLWLCTRVGLYPFWIMRTTLFRAHVILQMWYPVYYIFNGLLLVLLLIHVMWTYLILRIVVRMLLFKEIYDVRSSSEASGEDDDDA", "length": 173, "molWeight": 20570, "crc64": "E4812E04841665E9", "md5": "1AFEBACC70C12B1E2F38EF3B25346801"}, "extraAttributes": {"countByCommentType": {"PATHWAY": 2, "SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 3, "Domain": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B2E6549"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BHM2", "uniProtkbId": "A0AAQ5BHM2_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519453.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519453.1"}], "value": "Homeostatic iron regulator"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519453.1"}], "value": "HFE"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 38, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5042929106"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BHM2"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BHM2"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519453.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "14574404", "citationType": "journal article", "authors": ["Mungall A.J.", "Palmer S.A.", "Sims S.K.", "Edwards C.A.", "Ashurst J.L.", "Wilming L.", "Jones M.C.", "Horton R.", "Hunt S.E.", "Scott C.E.", "Gilbert J.G.", "Clamp M.E.", "Bethel G.", "Milne S.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Andrews T.D.", "Ashwell R.I.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beare D.M.", "Beasley H.", "Beasley O.", "Bird C.P.", "Blakey S.", "Bray-Allen S.", "Brook J.", "Brown A.J.", "Brown J.Y.", "Burford D.C.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Clark S.Y.", "Clark G.", "Clee C.M.", "Clegg S.", "Cobley V.", "Collier R.E.", "Collins J.E.", "Colman L.K.", "Corby N.R.", "Coville G.J.", "Culley K.M.", "Dhami P.", "Davies J.", "Dunn M.", "Earthrowl M.E.", "Ellington A.E.", "Evans K.A.", "Faulkner L.", "Francis M.D.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Ghori M.J.", "Gilby L.M.", "Gillson C.J.", "Glithero R.J.", "Grafham D.V.", "Grant M.", "Gribble S.", "Griffiths C.", "Griffiths M.", "Hall R.", "Halls K.S.", "Hammond S.", "Harley J.L.", "Hart E.A.", "Heath P.D.", "Heathcott R.", "Holmes S.J.", "Howden P.J.", "Howe K.L.", "Howell G.R.", "Huckle E.", "Humphray S.J.", "Humphries M.D.", "Hunt A.R.", "Johnson C.M.", "Joy A.A.", "Kay M.", "Keenan S.J.", "Kimberley A.M.", "King A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.R.", "Lloyd D.M.", "Loveland J.E.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Maslen G.L.", "Matthews L.", "McCann O.T.", "McLaren S.J.", "McLay K.", "McMurray A.", "Moore M.J.", "Mullikin J.C.", "Niblett D.", "Nickerson T.", "Novik K.L.", "Oliver K.", "Overton-Larty E.K.", "Parker A.", "Patel R.", "Pearce A.V.", "Peck A.I.", "Phillimore B.", "Phillips S.", "Plumb R.W.", "Porter K.M.", "Ramsey Y.", "Ranby S.A.", "Rice C.M.", "Ross M.T.", "Searle S.M.", "Sehra H.K.", "Sheridan E.", "Skuce C.D.", "Smith S.", "Smith M.", "Spraggon L.", "Squares S.L.", "Steward C.A.", "Sycamore N.", "Tamlyn-Hall G.", "Tester J.", "Theaker A.J.", "Thomas D.W.", "Thorpe A.", "Tracey A.", "Tromans A.", "Tubby B.", "Wall M.", "Wallis J.M.", "West A.P.", "White S.S.", "Whitehead S.L.", "Whittaker H.", "Wild A.", "Willey D.J.", "Wilmer T.E.", "Wood J.M.", "Wray P.W.", "Wyatt J.C.", "Young L.", "Younger R.M.", "Bentley D.R.", "Coulson A.", "Durbin R.", "Hubbard T.", "Sulston J.E.", "Dunham I.", "Rogers J.", "Beck S."], "citationCrossReferences": [{"database": "PubMed", "id": "14574404"}, {"database": "DOI", "id": "10.1038/nature02055"}], "title": "The DNA sequence and analysis of human chromosome 6.", "publicationDate": "2003", "journal": "Nature", "firstPage": "805", "lastPage": "811", "volume": "425"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519453.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519453.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519453.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "U91328", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000714164.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519453.1"}, {"key": "GeneId", "value": "ENSG00000010704.20"}]}, {"database": "HGNC", "id": "HGNC:4886", "properties": [{"key": "GeneName", "value": "HFE"}]}, {"database": "OpenTargets", "id": "ENSG00000010704", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT01130000278293", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 6"}]}], "sequence": {"value": "MGPRARPALLLLMLLQTAVLQGRLLRGAMGHYVLAERE", "length": 38, "molWeight": 4216, "crc64": "9C6AC1AC172D98B1", "md5": "2F67BF2F1DA0BEB8289A0146F5849544"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0032CF26AF"}, "cluster_size": 2, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UTE9", "uniProtkbId": "A0AAT9UTE9_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41606.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41606.1"}], "value": "Cytochrome P450 6PU1 short isoform 1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 24, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41606.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117166", "properties": [{"key": "ProteinId", "value": "WIM41606.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR002402", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-II"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00464", "properties": [{"key": "EntryName", "value": "EP450II"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDLFSVTLIILTAITVLAYLYYLLKKQFDYWKVLNVPYLETPSYIFGQAKRCATGELSLAESHLQIYRDLAPHKYGGIFLFQNPSLIVRDPELVKHVLAKDFTNFYDRGSYFAKPYEPLTRHLFNLTGEEWKTIRTKLTPTFSGGKLKLMFAYVKECVDELITVIDELHDEEIEMKDLMARYTVDVISSCAFGLKTNSLRHPDAEFKKMGTQALSPTTWTRIKDTLTAISPKLVYFLKIRTFDTQVTEFFNRIVRQTVEYREKNNITRNDFLHLVTQLKKKDETDSLKNNSDGIILNEKSVELTLDLVTAQCFVIFLGGFETSSSALSFTLFELSRNPRVQQELQQDVDRVFDKYHDQITYESLQETTYADMVINGNIVSISDYACELDYHCCPDNSSKN", "length": 400, "molWeight": 46255, "crc64": "4928A3FC5DFA5809", "md5": "63DF29E2BD30AE9748FEB1BB36C24C52"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Transmembrane": 1}, "uniParcId": "UPI0035D279B2"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6ND20", "uniProtkbId": "A0AAU6ND20_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59740.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59740.1"}], "value": "OBP26"}}], "flag": "Fragment"}, "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59740.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59740.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420100", "properties": [{"key": "ProteinId", "value": "WWA59740.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00708", "properties": [{"key": "EntryName", "value": "PhBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "EHGVTDAEIQAAKEAGSTAGIKPCFIGCVVKKIGFINEKGDYDLDAGLKKLREHVKDDEKYNRIENTAKACSSVQDKVVTDGTAGCERSVLLVECFLTHKARLII", "length": 105, "molWeight": 11423, "crc64": "FD55DC519615EA57", "md5": "5ED4AC628013E5A697B046F1BF47EC0B"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI0035D27346"}, "cluster_size": 2, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA94X319", "uniProtkbId": "A0AA94X319_ACASC", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Acanthopagrus schlegelii", "commonName": "Black porgy", "taxonId": 72011, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UNG35094.1"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Actinopterygii", "Neopterygii", "Teleostei", "Neoteleostei", "Acanthomorphata", "Eupercaria", "Spariformes", "Sparidae", "Acanthopagrus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UNG35094.1"}], "value": "Ulk1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 17, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 18, "modifier": "EXACT"}, "end": {"value": 53, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041640084"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B2F42CQRB6H2U", "citationType": "submission", "authors": ["Li X.", "Shen Y.", "Bao Y.", "Wu Z.", "Yang B."], "title": "Regulatory effects of dietary lipid levels on growth performance, lipid metabolism, ERS and inflammatory response of juvenile black seabream Acanthopagrus schlegelii under low-salinity environment.", "publicationDate": "NOV-2021", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "UNG35094.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OL321597", "properties": [{"key": "ProteinId", "value": "UNG35094.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MQLWSLWILLSLQSRKASLDALLTCEQTKKIEVWIERKSSQDHLTNVFIQYVV", "length": 53, "molWeight": 6291, "crc64": "666CD72AB1283996", "md5": "9F506D3B4BEF92A074E194526361ED2C"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI002B2D62D4"}, "cluster_size": 1, "family": "Sparidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HC94", "uniProtkbId": "A0AA96HC94_9METZ", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 9, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Latrunculia apicalis", "taxonId": 1325597, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25256.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Heteroscleromorpha", "Poecilosclerida", "Latrunculiidae", "Latrunculia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25256.1"}], "value": "Hypoxia-inducible factor 1"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 49, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 255, "modifier": "EXACT"}, "end": {"value": 342, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 436, "modifier": "EXACT"}, "end": {"value": 487, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 262, "modifier": "EXACT"}, "end": {"value": 278, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 288, "modifier": "EXACT"}, "end": {"value": 302, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 321, "modifier": "EXACT"}, "end": {"value": 338, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 436, "modifier": "EXACT"}, "end": {"value": 451, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 453, "modifier": "EXACT"}, "end": {"value": 469, "modifier": "EXACT"}}, "description": "Pro residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 474, "modifier": "EXACT"}, "end": {"value": 487, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 642, "modifier": "EXACT"}, "end": {"value": 642, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25256.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25256.1"}], "value": "Latr1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25256.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ354991", "properties": [{"key": "ProteinId", "value": "WNN25256.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14598", "properties": [{"key": "EntryName", "value": "PAS_11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MVISRDGCVLFSSESIANYLGLRQVDVIGARVQDIIHPQDCSEIIRILQTRGLDTEQVFDENKPLRRKFVMRMRCAFTPSVRCITRCSNFKPIYCSCFLKFGKSGPQKGEFLGMMVFCKLATLSKIKEMVVGTFFKTKHSLDLSYTNVDTRIRWILGYDPTEMTGLKAYQYFHPQDLGVTSSCHMNLLSRGISHSPCYRIMTRWGDWLWCRSKSFMLYSKGSSLPDGIAIYTWIVRIDEEDDRMLAIKKGDDGEAERKTYDSFSGSISSSGGSLDVSSLANPFGQTDSPSSSSSSPQTPPTSLAMKEAVKPVSEGFPYSPPLSDKSPPQLQSSPQSGPAYPPVGVVTGPHNTSSLLMGSPPMGVAISSPPMGMGVAVSSPPMGKGVAVSSPSMGMGISSPSMMGVVTSPSSVMTEYSPSRNLDTYMNPGFSSDLSDQSYTFDHSPPLNQNFNPSPPYTPYNSPPYPDASPPYSQATTQGNTIPSSVPHTSQILPSMAPPLPTQQPQHQQLVSDVYSSRLTSQGNSVTYPHGNMGPVIDVQGMFIPSGNSELNIAGFAESDLVPNSNLNMIGFTEFEVTPNHVPLLSQAPTHVRQTVISSARQRYSGVVPTGHTSMLGAVPGGHVTRNVHHADNGDTKGPSAG", "length": 642, "molWeight": 69436, "crc64": "DCE5473CF4B26D83", "md5": "3547674F606D69028427FD2B83416C4B"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "Region": 2, "Compositional bias": 6, "Non-terminal residue": 1}, "uniParcId": "UPI002B2EE182"}, "cluster_size": 1, "family": "Latrunculiidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96HCF2", "uniProtkbId": "A0AA96HCF2_9ECHI", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Crinoidea sp", "taxonId": 3077342, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25276.1"}], "lineage": ["Eukaryota", "Metazoa", "Echinodermata", "Pelmatozoa", "Crinoidea"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25276.1"}], "value": "Hypoxia-inducible factor 1"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 40, "modifier": "EXACT"}, "end": {"value": 93, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Domain", "location": {"start": {"value": 112, "modifier": "EXACT"}, "end": {"value": 180, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Domain", "location": {"start": {"value": 286, "modifier": "EXACT"}, "end": {"value": 328, "modifier": "EXACT"}}, "description": "PAS", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50112"}]}, {"type": "Region", "location": {"start": {"value": 31, "modifier": "EXACT"}, "end": {"value": 53, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25276.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 376, "modifier": "EXACT"}, "end": {"value": 376, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25276.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023159"}], "id": "KW-0010", "category": "Molecular function", "name": "Activator"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023278"}], "id": "KW-0379", "category": "PTM", "name": "Hydroxylation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022843"}], "id": "KW-0832", "category": "PTM", "name": "Ubl conjugation"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-G5HP7J6T5VHO", "citationType": "journal article", "authors": ["Belato F.A.", "Mello B.", "Coates C.J.", "Halanych K.M.", "Brown F.D.", "Morandini A.C.", "Leme J.M.", "Trindade R.I.F.", "Costa-Paiva E.M."], "title": "Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.", "publicationDate": "2023", "journal": "Geobiology", "firstPage": "0", "lastPage": "0", "volume": "0"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25276.1"}], "value": "Stal1", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNN25276.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ355011", "properties": [{"key": "ProteinId", "value": "WNN25276.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005737", "properties": [{"key": "GoTerm", "value": "C:cytoplasm"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005667", "properties": [{"key": "GoTerm", "value": "C:transcription regulator complex"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000977", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0071456", "properties": [{"key": "GoTerm", "value": "P:cellular response to hypoxia"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd11433", "properties": [{"key": "EntryName", "value": "bHLH-PAS_HIF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "CDD", "id": "cd00130", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000005", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1 subunit alpha"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "3.30.450.20:FF:000015", "properties": [{"key": "EntryName", "value": "Hypoxia-inducible factor 1-alpha isoform 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.30.450.20", "properties": [{"key": "EntryName", "value": "PAS domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR001067", "properties": [{"key": "EntryName", "value": "Nuc_translocat"}]}, {"database": "InterPro", "id": "IPR000014", "properties": [{"key": "EntryName", "value": "PAS"}]}, {"database": "InterPro", "id": "IPR035965", "properties": [{"key": "EntryName", "value": "PAS-like_dom_sf"}]}, {"database": "InterPro", "id": "IPR013767", "properties": [{"key": "EntryName", "value": "PAS_fold"}]}, {"database": "NCBIfam", "id": "TIGR00229", "properties": [{"key": "EntryName", "value": "sensory_box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043", "properties": [{"key": "EntryName", "value": "HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR23043:SF17", "properties": [{"key": "EntryName", "value": "PROTEIN SIMILAR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF23171", "properties": [{"key": "EntryName", "value": "bHLH_HIF1A"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00989", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF14598", "properties": [{"key": "EntryName", "value": "PAS_11"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00785", "properties": [{"key": "EntryName", "value": "NCTRNSLOCATR"}]}, {"database": "SMART", "id": "SM00353", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00091", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55785", "properties": [{"key": "EntryName", "value": "PYP-like sensor domain (PAS domain)"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50112", "properties": [{"key": "EntryName", "value": "PAS"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "IYFSCGGTNICFRMSGTDQCSLGENKYTTVTKPKRKNSDKRKEKSRNAARSRRGKETEIFYDLSHQLPLPRNLCQQLDKAGIMRLCISYLKTKQLIPKKFDGVCIVNTDNHSKVALEAIVDSLYLKSLEGFVFVLSQTGDIVYLSENVSKYLGLLQIELMGQSIYEFTHPCDHEEVREQLADRPGICVNNKVREHQNFLLRLKCTLTDKGKTVNLKSAIYKVVQCIGHKEWIDSVESKTSPFRMPSSLFLVVIAMPIPHPSNIENLLDSKTFVSRHNMKMYFTDCDERIEELLGYKPSEVEGRSFYNFFHAADNEIVEKNLKDLYSKGQSVIGHYRFLARNGGYAWVNTEATIIYHSKTCKPQCIVCLHYMISGIE", "length": 376, "molWeight": 43060, "crc64": "E84C13746E6C5762", "md5": "FA27FC1E51AA0F14F3096C731A3F38B0"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 3, "Region": 1, "Non-terminal residue": 2}, "uniParcId": "UPI002B323197"}, "cluster_size": 1, "family": "Unknown_Family_TaxID_3077342"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96UUI6", "uniProtkbId": "A0AA96UUI6_9CAEN", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 7, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Colubraria reticulata", "taxonId": 604273, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29088.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Mollusca", "Gastropoda", "Caenogastropoda", "Neogastropoda", "Buccinoidea", "Buccinidae", "Colubraria"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29088.1"}], "value": "VWACP-5"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004613"}], "value": "Secreted", "id": "SL-0243"}}]}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 425, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041718187"}, {"type": "Domain", "location": {"start": {"value": 35, "modifier": "EXACT"}, "end": {"value": 211, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}, {"type": "Domain", "location": {"start": {"value": 231, "modifier": "EXACT"}, "end": {"value": 404, "modifier": "EXACT"}}, "description": "VWFA", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50234"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023157"}], "id": "KW-1015", "category": "PTM", "name": "Disulfide bond"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022553"}], "id": "KW-0597", "category": "PTM", "name": "Phosphoprotein"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022737"}], "id": "KW-0677", "category": "Domain", "name": "Repeat"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022525"}], "id": "KW-0964", "category": "Cellular component", "name": "Secreted"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-95I90BCME92O", "citationType": "submission", "authors": ["Modica M.V.", "Gerdol M.", "Fracarossi D.", "Cervelli M.", "Reinoso Sanchez J.F.", "Leone S.", "Tartaglia G.", "Milanetti E.", "Vassalli Q.A.", "Ruggeri Z.M.", "Oliverio M."], "title": "A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.", "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNX29088.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR651425", "properties": [{"key": "ProteinId", "value": "WNX29088.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005576", "properties": [{"key": "GoTerm", "value": "C:extracellular region"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "CDD", "id": "cd01450", "properties": [{"key": "EntryName", "value": "vWFA_subfamily_ECM"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "Gene3D", "id": "3.40.50.410", "properties": [{"key": "EntryName", "value": "von Willebrand factor, type A domain"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "InterPro", "id": "IPR050525", "properties": [{"key": "EntryName", "value": "ECM_Assembly_Org"}]}, {"database": "InterPro", "id": "IPR002035", "properties": [{"key": "EntryName", "value": "VWF_A"}]}, {"database": "InterPro", "id": "IPR036465", "properties": [{"key": "EntryName", "value": "vWFA_dom_sf"}]}, {"database": "PANTHER", "id": "PTHR24020", "properties": [{"key": "EntryName", "value": "COLLAGEN ALPHA"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24020:SF77", "properties": [{"key": "EntryName", "value": "VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00092", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PRINTS", "id": "PR00453", "properties": [{"key": "EntryName", "value": "VWFADOMAIN"}]}, {"database": "SMART", "id": "SM00327", "properties": [{"key": "EntryName", "value": "VWA"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "SUPFAM", "id": "SSF53300", "properties": [{"key": "EntryName", "value": "vWA-like"}, {"key": "MatchStatus", "value": "2"}]}, {"database": "PROSITE", "id": "PS50234", "properties": [{"key": "EntryName", "value": "VWFA"}, {"key": "MatchStatus", "value": "2"}]}], "sequence": {"value": "MELIHLLPVLLILCGNVPATSSAAPRVVPCVRPTEVVFLVDTSHFVDEDFLGQMAFIKSLLPYFNVSSTTTRMAAISYSKGAKVVFDLDTFSNTTGVQKGLGKVKFTKDQSLDSHTAIRLARKLLLHKSRKEASRNIVYFTNGKATEFDEALEEAREVRIKGILLFAVGVESKVDVEELGQLATEKNERFVFIAKAIKFLHRHKYLLAKHICSGTAPVIKPPAVRCNKPADIVFLVDTSRSMSYKDFSLELKFVQDMIRQFHVSRRTTRVAVVSYSSGFKEEISLDQFQSSGSTMKAVGSITFTKGDRRDSHEAIQHALDLLSHQPRDLAARVIIYITGGIATDADITLKVAERVRTKGILMFSVGVVQNANTEELGQIATRNTAQFVYSVNSLDGLSTISRSLGPRVCTAVRAAIQPQLPRAGS", "length": 425, "molWeight": 46880, "crc64": "31734DDD720F4D6C", "md5": "A8FDB35B86E6FDD478F5C0755087E5DB"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 2}, "uniParcId": "UPI002B281414"}, "cluster_size": 1, "family": "Buccinidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96LAR9", "uniProtkbId": "A0AA96LAR9_MEDSA", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Medicago sativa", "commonName": "Alfalfa", "taxonId": 3879, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNP90972.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Fabales", "Fabaceae", "Papilionoideae", "50 kb inversion clade", "NPAAA clade", "Hologalegina", "IRL clade", "Trifolieae", "Medicago"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"recommendedName": {"fullName": {"evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50090"}], "value": "Myb-like domain-containing protein"}}}, "features": [{"type": "Domain", "location": {"start": {"value": 33, "modifier": "EXACT"}, "end": {"value": 103, "modifier": "EXACT"}}, "description": "Myb-like", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50090"}]}, {"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 41, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 54, "modifier": "EXACT"}, "end": {"value": 73, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 134, "modifier": "EXACT"}, "end": {"value": 182, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 26, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 138, "modifier": "EXACT"}, "end": {"value": 160, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-DID462M1ML21Q", "citationType": "submission", "authors": ["Pu J."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNP90972.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR463505", "properties": [{"key": "ProteinId", "value": "WNP90972.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "CDD", "id": "cd12203", "properties": [{"key": "EntryName", "value": "GT1"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.10.60", "properties": [{"key": "EntryName", "value": "Homeodomain-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR044822", "properties": [{"key": "EntryName", "value": "Myb_DNA-bind_4"}]}, {"database": "InterPro", "id": "IPR001005", "properties": [{"key": "EntryName", "value": "SANT/Myb"}]}, {"database": "PANTHER", "id": "PTHR47211:SF4", "properties": [{"key": "EntryName", "value": "MYB_SANT-LIKE DNA-BINDING DOMAIN PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR47211", "properties": [{"key": "EntryName", "value": "TRIHELIX TRANSCRIPTION FACTOR ASR3"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF13837", "properties": [{"key": "EntryName", "value": "Myb_DNA-bind_4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50090", "properties": [{"key": "EntryName", "value": "MYB_LIKE"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MALEQPNPNSDDGTVNGNGTPPSSAVNGGEDGKPTARLPRWTRQEILVLIQGKSDAESRFKPGRNGSGFGSSEPKWALVSSYCKKHGVNRGPIQCRKRWSNLAGDYKKIKEWESQCFNVTSIDEKQFLPLLRGCQGEGNAQGTNNEKQPASNPETGSTSQGERKRKRFATNGDGNEEEESLHSQLIDVLEKNGKMLSEQLEAQNINFQLDRQQQNETASSIVAVLDKLANALGKIADKL", "length": 239, "molWeight": 26197, "crc64": "C87C4461A0280274", "md5": "8E2F741DBF79CCEFC78F205B4596911F"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 3, "Compositional bias": 2}, "uniParcId": "UPI002B317AE7"}, "cluster_size": 1, "family": "Fabaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA86IWR2", "uniProtkbId": "A0AA86IWR2_AURAU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-11-27", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Aurelia aurita", "commonName": "Moon jellyfish", "synonyms": ["Medusa aurita"], "taxonId": 6145, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53440.1"}], "lineage": ["Eukaryota", "Metazoa", "Cnidaria", "Scyphozoa", "Semaeostomeae", "Ulmaridae", "Aurelia"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53440.1"}], "value": "Pituitary homeobox 1-like protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53440.1"}], "value": "PITX1"}}], "features": [{"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53440.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53440.1"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53440.1"}], "id": "KW-0371", "category": "Domain", "name": "Homeobox"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-B2HUVLRISDPSM", "citationType": "submission", "authors": ["Nakanishi T.", "Sarper S.E."], "title": "Tetraradial symmetry disturbance and recovery at feeding-dependent tentacle initiations in Aurelia aurita polyps.", "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BES53440.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC778155", "properties": [{"key": "ProteinId", "value": "BES53440.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}], "sequence": {"value": "KWRKKERHLERPDMFNFATRLDSACAFDRRPQYSSSVYGVPNYSPCSSSDFSRSGHYYPQNSHWYLDYQKSTSPTWYSSQYSDLSRISSSYSCQQTPSLLRSNEMLSLPLTPTTPVFQQNTSYP", "length": 124, "molWeight": 14493, "crc64": "BAA3F405DB3988AE", "md5": "4E26DDB73B39E98530F95E5D289E354E"}, "extraAttributes": {"countByFeatureType": {"Non-terminal residue": 1}, "uniParcId": "UPI002B2FF0DB"}, "cluster_size": 1, "family": "Ulmaridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB38ZEN8", "uniProtkbId": "A0AB38ZEN8_9HEMI", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Oncocephalus sp", "taxonId": 2944721, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02724.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Cimicomorpha", "Reduviidae", "Stenopodainae", "Oncocephalus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02724.1"}], "value": "Heteropteran venom family 16 protein 1"}}]}, "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 16, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 17, "modifier": "EXACT"}, "end": {"value": 127, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5044325049"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-RUDC6SE6IKBL", "citationType": "submission", "authors": ["Zdenek C.N.", "Cardoso F.C.", "Robinson S.D.", "Mercedes R.S.", "Raidjoe E.R.", "Hernandez-Vargas M.J.", "Jin J.", "Corzo G.", "Vetter I.", "King G.F.", "Fry B.G.", "Walker A."], "title": "Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).", "publicationDate": "MAR-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WXI02724.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP517474", "properties": [{"key": "ProteinId", "value": "WXI02724.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}], "sequence": {"value": "MSIWFTLLLVCPLALSMPIEEDVDFTNMDPHQLTEHLAYKMQEHFGDNWKNRVPELQKKLEEIVNRKEQGLPIDSEEIAGSPKPWETAQTMLKWKHILHKIKHIGGKVIKGAAINIAGKAIAGAIAG", "length": 127, "molWeight": 14289, "crc64": "9455DA4E2670C056", "md5": "5D7C5F317D772D27C65BA93359799307"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI00388BBF41"}, "cluster_size": 2, "family": "Reduviidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AB39JBD1", "uniProtkbId": "A0AB39JBD1_SALZA", "entryAudit": {"firstPublicDate": "2025-02-05", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2025-02-05", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Salacca zalacca", "commonName": "Snake palm", "synonyms": ["Salacca edulis"], "taxonId": 145711, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88999.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "Liliopsida", "Arecaceae", "Calamoideae", "Calameae", "Salaccinae", "Salacca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88999.1"}], "value": "Cucumber peeling cupredoxin-like protein"}}], "flag": "Fragment"}, "features": [{"type": "Domain", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 69, "modifier": "EXACT"}}, "description": "Phytocyanin", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS51485"}]}, {"type": "Region", "location": {"start": {"value": 67, "modifier": "EXACT"}, "end": {"value": 87, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88999.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 111, "modifier": "EXACT"}, "end": {"value": 111, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88999.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-9V2V54QP4C7C3", "citationType": "submission", "authors": ["Tong W."], "publicationDate": "AUG-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XDN88999.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PQ120707", "properties": [{"key": "ProteinId", "value": "XDN88999.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0009055", "properties": [{"key": "GoTerm", "value": "F:electron transfer activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "2.60.40.420", "properties": [{"key": "EntryName", "value": "Cupredoxins - blue copper proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR008972", "properties": [{"key": "EntryName", "value": "Cupredoxin"}]}, {"database": "InterPro", "id": "IPR039391", "properties": [{"key": "EntryName", "value": "Phytocyanin-like"}]}, {"database": "InterPro", "id": "IPR003245", "properties": [{"key": "EntryName", "value": "Phytocyanin_dom"}]}, {"database": "PANTHER", "id": "PTHR33021", "properties": [{"key": "EntryName", "value": "BLUE COPPER PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR33021:SF496", "properties": [{"key": "EntryName", "value": "OS08G0482700 PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02298", "properties": [{"key": "EntryName", "value": "Cu_bind_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF49503", "properties": [{"key": "EntryName", "value": "Cupredoxins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS51485", "properties": [{"key": "EntryName", "value": "PHYTOCYANIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VFNFLAGVHNVIEVPKSSYDACSAKNQIGPNLTASPATVTITSSGTYYYICGFSGHCSLGQKLAITTSSSASPTPAPTPGGSSSAPPQARPFGFSLAVAFLSVASSCLLFL", "length": 111, "molWeight": 11265, "crc64": "EEE9CCE7A024643B", "md5": "90923F1BB1D314DF10B19B8CC806A9E6"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Non-terminal residue": 2}, "uniParcId": "UPI00388BC3CA"}, "cluster_size": 1, "family": "Arecaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BH97", "uniProtkbId": "A0AAQ5BH97_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519330.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519330.1"}], "value": "Triadin"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519330.1"}], "value": "TRDN"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004157"}], "value": "Sarcoplasmic reticulum membrane", "id": "SL-0241"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004157"}], "value": "Single-pass type II membrane protein", "id": "SL-9906"}}]}], "features": [{"type": "Region", "location": {"start": {"value": 49, "modifier": "EXACT"}, "end": {"value": 144, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 49, "modifier": "EXACT"}, "end": {"value": 63, "modifier": "EXACT"}}, "description": "Acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 64, "modifier": "EXACT"}, "end": {"value": 134, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BH97"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAQ5BH97"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022951"}], "id": "KW-0703", "category": "Cellular component", "name": "Sarcoplasmic reticulum"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519330.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "14574404", "citationType": "journal article", "authors": ["Mungall A.J.", "Palmer S.A.", "Sims S.K.", "Edwards C.A.", "Ashurst J.L.", "Wilming L.", "Jones M.C.", "Horton R.", "Hunt S.E.", "Scott C.E.", "Gilbert J.G.", "Clamp M.E.", "Bethel G.", "Milne S.", "Ainscough R.", "Almeida J.P.", "Ambrose K.D.", "Andrews T.D.", "Ashwell R.I.", "Babbage A.K.", "Bagguley C.L.", "Bailey J.", "Banerjee R.", "Barker D.J.", "Barlow K.F.", "Bates K.", "Beare D.M.", "Beasley H.", "Beasley O.", "Bird C.P.", "Blakey S.", "Bray-Allen S.", "Brook J.", "Brown A.J.", "Brown J.Y.", "Burford D.C.", "Burrill W.", "Burton J.", "Carder C.", "Carter N.P.", "Chapman J.C.", "Clark S.Y.", "Clark G.", "Clee C.M.", "Clegg S.", "Cobley V.", "Collier R.E.", "Collins J.E.", "Colman L.K.", "Corby N.R.", "Coville G.J.", "Culley K.M.", "Dhami P.", "Davies J.", "Dunn M.", "Earthrowl M.E.", "Ellington A.E.", "Evans K.A.", "Faulkner L.", "Francis M.D.", "Frankish A.", "Frankland J.", "French L.", "Garner P.", "Garnett J.", "Ghori M.J.", "Gilby L.M.", "Gillson C.J.", "Glithero R.J.", "Grafham D.V.", "Grant M.", "Gribble S.", "Griffiths C.", "Griffiths M.", "Hall R.", "Halls K.S.", "Hammond S.", "Harley J.L.", "Hart E.A.", "Heath P.D.", "Heathcott R.", "Holmes S.J.", "Howden P.J.", "Howe K.L.", "Howell G.R.", "Huckle E.", "Humphray S.J.", "Humphries M.D.", "Hunt A.R.", "Johnson C.M.", "Joy A.A.", "Kay M.", "Keenan S.J.", "Kimberley A.M.", "King A.", "Laird G.K.", "Langford C.", "Lawlor S.", "Leongamornlert D.A.", "Leversha M.", "Lloyd C.R.", "Lloyd D.M.", "Loveland J.E.", "Lovell J.", "Martin S.", "Mashreghi-Mohammadi M.", "Maslen G.L.", "Matthews L.", "McCann O.T.", "McLaren S.J.", "McLay K.", "McMurray A.", "Moore M.J.", "Mullikin J.C.", "Niblett D.", "Nickerson T.", "Novik K.L.", "Oliver K.", "Overton-Larty E.K.", "Parker A.", "Patel R.", "Pearce A.V.", "Peck A.I.", "Phillimore B.", "Phillips S.", "Plumb R.W.", "Porter K.M.", "Ramsey Y.", "Ranby S.A.", "Rice C.M.", "Ross M.T.", "Searle S.M.", "Sehra H.K.", "Sheridan E.", "Skuce C.D.", "Smith S.", "Smith M.", "Spraggon L.", "Squares S.L.", "Steward C.A.", "Sycamore N.", "Tamlyn-Hall G.", "Tester J.", "Theaker A.J.", "Thomas D.W.", "Thorpe A.", "Tracey A.", "Tromans A.", "Tubby B.", "Wall M.", "Wallis J.M.", "West A.P.", "White S.S.", "Whitehead S.L.", "Whittaker H.", "Wild A.", "Willey D.J.", "Wilmer T.E.", "Wood J.M.", "Wray P.W.", "Wyatt J.C.", "Young L.", "Younger R.M.", "Bentley D.R.", "Coulson A.", "Durbin R.", "Hubbard T.", "Sulston J.E.", "Dunham I.", "Rogers J.", "Beck S."], "citationCrossReferences": [{"database": "PubMed", "id": "14574404"}, {"database": "DOI", "id": "10.1038/nature02055"}], "title": "The DNA sequence and analysis of human chromosome 6.", "publicationDate": "2003", "journal": "Nature", "firstPage": "805", "lastPage": "811", "volume": "425"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519330.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519330.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000519330.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AL133257", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AL357352", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AL445259", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AL603902", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "AL603911", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000714039.1", "properties": [{"key": "ProteinId", "value": "ENSP00000519330.1"}, {"key": "GeneId", "value": "ENSG00000186439.16"}]}, {"database": "HGNC", "id": "HGNC:12261", "properties": [{"key": "GeneName", "value": "TRDN"}]}, {"database": "OpenTargets", "id": "ENSG00000186439", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT00510000049207", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 6"}]}, {"database": "GO", "id": "GO:0033017", "properties": [{"key": "GoTerm", "value": "C:sarcoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005102", "properties": [{"key": "GoTerm", "value": "F:signaling receptor binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR010798", "properties": [{"key": "EntryName", "value": "Triadin"}]}, {"database": "PANTHER", "id": "PTHR14106", "properties": [{"key": "EntryName", "value": "TRIADIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR14106:SF0", "properties": [{"key": "EntryName", "value": "TRIADIN"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MFDLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKASSKTQSLGDNLISASWALSREFSRAMLSQHFGIIKTGR", "length": 176, "molWeight": 20216, "crc64": "4BD6DA952CAEA23F", "md5": "9B0CB44689E75DE31C059821A7C72E5F"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Region": 1, "Compositional bias": 2}, "uniParcId": "UPI0032CC52FC"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU86", "uniProtkbId": "A0AAT9UU86_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41698.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41698.1"}], "value": "Cytochrome P450 4461G1"}}]}, "comments": [{"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00003690"}], "value": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides"}], "commentType": "FUNCTION"}, {"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 439, "modifier": "EXACT"}, "end": {"value": 439, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602403-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41698.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117258", "properties": [{"key": "ProteinId", "value": "WIM41698.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002403", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-IV"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050196", "properties": [{"key": "EntryName", "value": "Cytochrome_P450_Monoox"}]}, {"database": "PANTHER", "id": "PTHR24291:SF189", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 4C3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24291", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450 FAMILY 4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00465", "properties": [{"key": "EntryName", "value": "EP450IV"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDLIITITCVIVVTILCKYVYKKKNQRFYRLLEQFPSNPTYPLIGNIRLSHLSPDAFRENVANLMESTDRLIFWLGPKAFLLLKNHNDISAVSNQCQNREVFGLMDEWGGLGIATAPEEEWKKSRKLLTPAFSSQMLRKYLEVFKRNSLILVDKLKPLADSDQEFDIWPYTLSININTIVENTTGVTYGDKGEIETDYGHAITKGMQSIANRWLSPWLYVRFIYWIYLYITGEYKLIKKVQDLPTKIIKEVMKDSKNLSNQLENANSSKTIVDLLVKGNSNEYGFTEIRLRDELLHIIVTGSETTALTMSFTILMLAMHQQIQQRVYEEITQLSNDTDELTIDHLTNDLKYLEQCIKETARIHAPVGILLLKPRKELTLNDGKIIPKELCIAMCNHLRHLDSDLYENPEKWDPEHYSEAAVAKRPKHSDTPFGNGPRSCLGNKYAIMSIKTQLVHILRNFHISTNLKEFTMQDLQMDLSIRSRIGYPVKLTSRR", "length": 494, "molWeight": 57068, "crc64": "F617EB926BD11320", "md5": "5DB3DD32509C1913C47F79A0F940F840"}, "extraAttributes": {"countByCommentType": {"FUNCTION": 1, "COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D3508E"}, "cluster_size": 1, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QKD4", "uniProtkbId": "A0AAU0QKD4_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56500.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56500.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 12, "modifier": "EXACT"}, "end": {"value": 32, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 67, "modifier": "EXACT"}, "end": {"value": 88, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 225, "modifier": "EXACT"}, "end": {"value": 242, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56500.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56500.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56500.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56500.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970393", "properties": [{"key": "ProteinId", "value": "WPO56500.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "VNQVEKYARISLCFLGTTIILNLSIWIIVPIVDYLQNKELLTRQKYELWTLLYLHAPFDYSYNVHNWIIMQIFISVISVSGDIILVVFNTINYIFISNLNGHIQILAHKIQSLHKIDMTQGDIQLKLQTIISYHSFIIEYFEDLQCAFGLNVMENYFQHTFVIMVIFFQLVIGPTGSEDLADIIYDLPWEDMCKRNRFMVLMMLLKTRAPCIFCVPGGFRTGFRPMISIIICLFSFYIVLSIRNGG", "length": 246, "molWeight": 28673, "crc64": "8E80132C5EDEB1DB", "md5": "0C81560A077EF1ACB33B1422292FD2BB"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 3, "Non-terminal residue": 1}, "uniParcId": "UPI003092DC90"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAQ5BGR6", "uniProtkbId": "A0AAQ5BGR6_HUMAN", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 6, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Homo sapiens", "commonName": "Human", "taxonId": 9606, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518990.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Primates", "Haplorrhini", "Catarrhini", "Hominidae", "Homo"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518990.1"}], "value": "Desmocollin 2"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518990.1"}], "value": "DSC2"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 31, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 32, "modifier": "EXACT"}, "end": {"value": 66, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043002220"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAQ5BGR6"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "11237011", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "authors": ["Lander E.S.", "Linton L.M.", "Birren B.", "Nusbaum C.", "Zody M.C.", "Baldwin J.", "Devon K.", "Dewar K.", "Doyle M.", "FitzHugh W.", "Funke R.", "Gage D.", "Harris K.", "Heaford A.", "Howland J.", "Kann L.", "Lehoczky J.", "LeVine R.", "McEwan P.", "McKernan K.", "Meldrim J.", "Mesirov J.P.", "Miranda C.", "Morris W.", "Naylor J.", "Raymond C.", "Rosetti M.", "Santos R.", "Sheridan A.", "Sougnez C.", "Stange-Thomann N.", "Stojanovic N.", "Subramanian A.", "Wyman D.", "Rogers J.", "Sulston J.", "Ainscough R.", "Beck S.", "Bentley D.", "Burton J.", "Clee C.", "Carter N.", "Coulson A.", "Deadman R.", "Deloukas P.", "Dunham A.", "Dunham I.", "Durbin R.", "French L.", "Grafham D.", "Gregory S.", "Hubbard T.", "Humphray S.", "Hunt A.", "Jones M.", "Lloyd C.", "McMurray A.", "Matthews L.", "Mercer S.", "Milne S.", "Mullikin J.C.", "Mungall A.", "Plumb R.", "Ross M.", "Shownkeen R.", "Sims S.", "Waterston R.H.", "Wilson R.K.", "Hillier L.W.", "McPherson J.D.", "Marra M.A.", "Mardis E.R.", "Fulton L.A.", "Chinwalla A.T.", "Pepin K.H.", "Gish W.R.", "Chissoe S.L.", "Wendl M.C.", "Delehaunty K.D.", "Miner T.L.", "Delehaunty A.", "Kramer J.B.", "Cook L.L.", "Fulton R.S.", "Johnson D.L.", "Minx P.J.", "Clifton S.W.", "Hawkins T.", "Branscomb E.", "Predki P.", "Richardson P.", "Wenning S.", "Slezak T.", "Doggett N.", "Cheng J.F.", "Olsen A.", "Lucas S.", "Elkin C.", "Uberbacher E.", "Frazier M.", "Gibbs R.A.", "Muzny D.M.", "Scherer S.E.", "Bouck J.B.", "Sodergren E.J.", "Worley K.C.", "Rives C.M.", "Gorrell J.H.", "Metzker M.L.", "Naylor S.L.", "Kucherlapati R.S.", "Nelson D.L.", "Weinstock G.M.", "Sakaki Y.", "Fujiyama A.", "Hattori M.", "Yada T.", "Toyoda A.", "Itoh T.", "Kawagoe C.", "Watanabe H.", "Totoki Y.", "Taylor T.", "Weissenbach J.", "Heilig R.", "Saurin W.", "Artiguenave F.", "Brottier P.", "Bruls T.", "Pelletier E.", "Robert C.", "Wincker P.", "Smith D.R.", "Doucette-Stamm L.", "Rubenfield M.", "Weinstock K.", "Lee H.M.", "Dubois J.", "Rosenthal A.", "Platzer M.", "Nyakatura G.", "Taudien S.", "Rump A.", "Yang H.", "Yu J.", "Wang J.", "Huang G.", "Gu J.", "Hood L.", "Rowen L.", "Madan A.", "Qin S.", "Davis R.W.", "Federspiel N.A.", "Abola A.P.", "Proctor M.J.", "Myers R.M.", "Schmutz J.", "Dickson M.", "Grimwood J.", "Cox D.R.", "Olson M.V.", "Kaul R.", "Raymond C.", "Shimizu N.", "Kawasaki K.", "Minoshima S.", "Evans G.A.", "Athanasiou M.", "Schultz R.", "Roe B.A.", "Chen F.", "Pan H.", "Ramser J.", "Lehrach H.", "Reinhardt R.", "McCombie W.R.", "de la Bastide M.", "Dedhia N.", "Blocker H.", "Hornischer K.", "Nordsiek G.", "Agarwala R.", "Aravind L.", "Bailey J.A.", "Bateman A.", "Batzoglou S.", "Birney E.", "Bork P.", "Brown D.G.", "Burge C.B.", "Cerutti L.", "Chen H.C.", "Church D.", "Clamp M.", "Copley R.R.", "Doerks T.", "Eddy S.R.", "Eichler E.E.", "Furey T.S.", "Galagan J.", "Gilbert J.G.", "Harmon C.", "Hayashizaki Y.", "Haussler D.", "Hermjakob H.", "Hokamp K.", "Jang W.", "Johnson L.S.", "Jones T.A.", "Kasif S.", "Kaspryzk A.", "Kennedy S.", "Kent W.J.", "Kitts P.", "Koonin E.V.", "Korf I.", "Kulp D.", "Lancet D.", "Lowe T.M.", "McLysaght A.", "Mikkelsen T.", "Moran J.V.", "Mulder N.", "Pollara V.J.", "Ponting C.P.", "Schuler G.", "Schultz J.", "Slater G.", "Smit A.F.", "Stupka E.", "Szustakowski J.", "Thierry-Mieg D.", "Thierry-Mieg J.", "Wagner L.", "Wallis J.", "Wheeler R.", "Williams A.", "Wolf Y.I.", "Wolfe K.H.", "Yang S.P.", "Yeh R.F.", "Collins F.", "Guyer M.S.", "Peterson J.", "Felsenfeld A.", "Wetterstrand K.A.", "Patrinos A.", "Morgan M.J.", "de Jong P.", "Catanese J.J.", "Osoegawa K.", "Shizuya H.", "Choi S.", "Chen Y.J."], "citationCrossReferences": [{"database": "PubMed", "id": "11237011"}, {"database": "DOI", "id": "10.1038/35057062"}], "title": "Initial sequencing and analysis of the human genome.", "publicationDate": "2001", "journal": "Nature", "firstPage": "860", "lastPage": "921", "volume": "409"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518990.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 2, "citation": {"id": "15496913", "citationType": "journal article", "authoringGroup": ["International Human Genome Sequencing Consortium"], "citationCrossReferences": [{"database": "PubMed", "id": "15496913"}, {"database": "DOI", "id": "10.1038/nature03001"}], "title": "Finishing the euchromatic sequence of the human genome.", "publicationDate": "2004", "journal": "Nature", "firstPage": "931", "lastPage": "945", "volume": "431"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518990.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 3, "citation": {"id": "16177791", "citationType": "journal article", "authors": ["Nusbaum C.", "Zody M.C.", "Borowsky M.L.", "Kamal M.", "Kodira C.D.", "Taylor T.D.", "Whittaker C.A.", "Chang J.L.", "Cuomo C.A.", "Dewar K.", "FitzGerald M.G.", "Yang X.", "Abouelleil A.", "Allen N.R.", "Anderson S.", "Bloom T.", "Bugalter B.", "Butler J.", "Cook A.", "DeCaprio D.", "Engels R.", "Garber M.", "Gnirke A.", "Hafez N.", "Hall J.L.", "Norman C.H.", "Itoh T.", "Jaffe D.B.", "Kuroki Y.", "Lehoczky J.", "Lui A.", "Macdonald P.", "Mauceli E.", "Mikkelsen T.S.", "Naylor J.W.", "Nicol R.", "Nguyen C.", "Noguchi H.", "O'Leary S.B.", "O'Neill K.", "Piqani B.", "Smith C.L.", "Talamas J.A.", "Topham K.", "Totoki Y.", "Toyoda A.", "Wain H.M.", "Young S.K.", "Zeng Q.", "Zimmer A.R.", "Fujiyama A.", "Hattori M.", "Birren B.W.", "Sakaki Y.", "Lander E.S."], "citationCrossReferences": [{"database": "PubMed", "id": "16177791"}, {"database": "DOI", "id": "10.1038/nature03983"}], "title": "DNA sequence and analysis of human chromosome 18.", "publicationDate": "2005", "journal": "Nature", "firstPage": "551", "lastPage": "555", "volume": "437"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518990.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000005640"}]}, {"referenceNumber": 4, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSP00000518990.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "AC012417", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "EMBL", "id": "KF573685", "properties": [{"key": "ProteinId", "value": "-"}, {"key": "Status", "value": "NOT_ANNOTATED_CDS"}, {"key": "MoleculeType", "value": "Genomic_DNA"}]}, {"database": "Ensembl", "id": "ENST00000713686.1", "properties": [{"key": "ProteinId", "value": "ENSP00000518990.1"}, {"key": "GeneId", "value": "ENSG00000134755.19"}]}, {"database": "HGNC", "id": "HGNC:3036", "properties": [{"key": "GeneName", "value": "DSC2"}]}, {"database": "OpenTargets", "id": "ENSG00000134755", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GeneTree", "id": "ENSGT01030000234624", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000005640", "properties": [{"key": "Component", "value": "Chromosome 18"}]}], "sequence": {"value": "MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRGKEALKFVINPVLLW", "length": 66, "molWeight": 7174, "crc64": "8B3CBD5BA36D1DE9", "md5": "AB792A3433A7BAA1E4344D0B2FBA476B"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0032CDA88B"}, "cluster_size": 1, "family": "Hominidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96Y7I4", "uniProtkbId": "A0AA96Y7I4_PARAW", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-05-29", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 2, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Pardosa astrigera", "commonName": "Wolf spider", "taxonId": 317848, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA03677.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Araneae", "Araneomorphae", "Entelegynae", "Lycosoidea", "Lycosidae", "Pardosa"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA03677.1"}], "value": "NPC intracellular cholesterol transporter 2-like protein"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA03677.1"}], "value": "NPC2-2"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 18, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 19, "modifier": "EXACT"}, "end": {"value": 163, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5041665898"}, {"type": "Domain", "location": {"start": {"value": 23, "modifier": "EXACT"}, "end": {"value": 151, "modifier": "EXACT"}}, "description": "MD-2-related lipid-recognition", "evidences": [{"evidenceCode": "ECO:0000259", "source": "SMART", "id": "SM00737"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4814ODGAGOV0B", "citationType": "submission", "authors": ["Zhao M.", "Li R."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WOA03677.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR671209", "properties": [{"key": "ProteinId", "value": "WOA03677.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "Gene3D", "id": "2.60.40.770", "properties": [{"key": "EntryName", "value": "-"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR014756", "properties": [{"key": "EntryName", "value": "Ig_E-set"}]}, {"database": "InterPro", "id": "IPR003172", "properties": [{"key": "EntryName", "value": "ML_dom"}]}, {"database": "Pfam", "id": "PF02221", "properties": [{"key": "EntryName", "value": "E1_DerP2_DerF2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00737", "properties": [{"key": "EntryName", "value": "ML"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81296", "properties": [{"key": "EntryName", "value": "E set domains"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MWFVLLILSYSFARHVSSEQVSFIPCGENTFSSLYITPCNATTVNVNQTCVLMHGHNILFQAYFVSPFNSSSLQVATMITLEGVEVPSINSGYDPCFGSITPACPVTEGKTYFFQKLYNVQSEFPIGLMDLKLVILDMETKDVAGCGKIKILVAKNPDYMYLD", "length": 163, "molWeight": 18122, "crc64": "27BA1F9B95E43BCA", "md5": "35F34521F19A32D4D0F33E0C5DD87A58"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1, "Domain": 1}, "uniParcId": "UPI002B29156A"}, "cluster_size": 1, "family": "Lycosidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAN0N7P4", "uniProtkbId": "A0AAN0N7P4_9ACAR", "entryAudit": {"firstPublicDate": "2024-10-02", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-10-02", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Polyphagotarsonemus latus", "taxonId": 1204166, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34102.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Chelicerata", "Arachnida", "Acari", "Acariformes", "Trombidiformes", "Prostigmata", "Eleutherengona", "Heterostigmata", "Tarsonemoidea", "Tarsonemidae", "Polyphagotarsonemus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34102.1"}], "value": "G-protein coupled receptor 3"}}]}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Membrane", "id": "SL-0162"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004141"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 992, "modifier": "EXACT"}, "end": {"value": 1016, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1028, "modifier": "EXACT"}, "end": {"value": 1051, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1063, "modifier": "EXACT"}, "end": {"value": 1083, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1095, "modifier": "EXACT"}, "end": {"value": 1114, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1145, "modifier": "EXACT"}, "end": {"value": 1167, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1179, "modifier": "EXACT"}, "end": {"value": 1202, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 1339, "modifier": "EXACT"}, "end": {"value": 1360, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Domain", "location": {"start": {"value": 989, "modifier": "EXACT"}, "end": {"value": 1212, "modifier": "EXACT"}}, "description": "G-protein coupled receptors family 3 profile", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF00003"}]}, {"type": "Region", "location": {"start": {"value": 1437, "modifier": "EXACT"}, "end": {"value": 1471, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1500, "modifier": "EXACT"}, "end": {"value": 1541, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 1597, "modifier": "EXACT"}, "end": {"value": 1619, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1437, "modifier": "EXACT"}, "end": {"value": 1464, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1506, "modifier": "EXACT"}, "end": {"value": 1515, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 1598, "modifier": "EXACT"}, "end": {"value": 1607, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34102.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5JA9VEBLCC0MA", "citationType": "submission", "authors": ["Muthugoundar M.", "P J A.", "Augustine N."], "title": "Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).", "publicationDate": "JAN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WRW34102.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP155028", "properties": [{"key": "ProteinId", "value": "WRW34102.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0004930", "properties": [{"key": "GoTerm", "value": "F:G protein-coupled receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "InterPro", "id": "IPR017978", "properties": [{"key": "EntryName", "value": "GPCR_3_C"}]}, {"database": "Pfam", "id": "PF00003", "properties": [{"key": "EntryName", "value": "7tm_3"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MRVSTLYTKPILRFNVKWFSLILLINFLVPNNFVNCVSKCQKTLDETAQAYLDNRYNVNNFNKYNRLELTRKAYNNLESTQNREKNGIFVSQESRAFQMKPKLQQYNKANSPQINNGFKYDKYQSKYQKPSHRLSSSSNQTPHYFSTQALSHNKDNFFDNLQPPFILLSGDVYVAYFDCINQNNIDIETTAPLVQSAMSAVWAAHRFNQFNLTTSSMSIKLGVYFFDICDYEKIKGLNFFNETFKSSVNSLVDDNQIENYLKLIEFNSINNQINKHTAGIIPKTSVRSYQKNGKQQIHKMKPVIGLLVDMNKLSSQSITKLNNFDLPVININKFPDYENLSFESDIGLNKRIFNVYPSVQQLCKGVFSLIKKLNWTFALLDFGKQRLGKNLTSNDYSHIENKLSSHEQTFLGCLSKLSARDAAFTFRIDSTDAQNLDNEIIFLTNGKSQTFMNALVAGYLSNKSNRVIVTLDNLSSQLDTAIIDHHLAGKRFDFSNIRKGRSLEEFNNENGPFFVMPDWDISSEFFDFFNIELKNANIQSKHRFISKLSEQLLFKAFNTKTIKFSEQELNLLRPVVHQLKGNNDPKYQKNKFNLNLNKLLKSRNLFEVNNSPRVVHTIDGVWTLGFTLSNLSKEVCLLNNPSIIERKKNCLNQLLQVFDSNKPFVRNITIHLNESLNKNESASKKTKKNNRLFFNHNLQLATINYTINRLNDSQLQKVAYYSECCGFKVIHPSLDENFGLLTNSSMQPIYFKNRMNNSFKSTPLFGTRLSSTTKTKPLTSTIPTTIVSDEIKNYTEPNESTTESNNKITSILTTEIAETTLNILNKSASEIEDIVLNDKFNSTQMISSINDEVVNLIKKTDIIATTEKPKEVFKKKEEQKENKTSKGLSAINLFKKFYKKIDVDNLTSTIPPIEKKKLTIKPKENLKIIKEKFDFRVKTKKLYKNVDTFKKNNTSNIIADSTNEITSVSSVFDRHFSNQFKKNTEAEVEKRFSIVLLFLSIGGSLLTLYVFIFLLVKSCEGSLRHHSHQALALTQLVAILIVYCSSGLYVFQLNSFKINLRNSIHNVALALLFACLLQRALFLRAQKWIGLGGKISMLNQCIILLLIFGVQLALEVQKWSYETFNNQDSSNSELNLIKNQSSPTYFINGQLYLMFTSCLLLLVAFTARQQPFTYKEGKHIYLTSLICCPLYLGSVIFLFKYLTTMNYYNLQMQEINLNSTINLTAPQSLQWTSNISVLENKLKTVNLDKNQFHSNKTLLKNEILNSYLNRSTIIPKNDVLRSLQKVKRTTNLNQPEFEYFLKLNATNVNQLDYLENLKEYTDYQQRLNVIKFVDLVQSFILLVLATISLFGIFGPIIISIHKNEDLSKKQVSYSDSLSTAFTLFKTGTNSQQQFIINKGNEGKSFFNPFSFNQRNKDINTHFHSQFKQLTNSLKTPSQIKCSSSTNESITTRENNFTDTDSSSLENHDNNDLDQNIQLNKQTVNYNLNCESDIDEDFLSENDNTEQNDINDSKNSAIFPPPPLPSQFKFDNADNESKSPTSNRLIINTAAHIGSGAQFNYATTPNYHKFKYVLNNLSQNLGQPSTDQDKFSTILNQQSDDPITSSTHPSPPPHPSSNPIITTSYLDSSKTQIIRTNPIYEVNQFRSAYP", "length": 1649, "molWeight": 188972, "crc64": "F79A02C45441ED76", "md5": "7B16387EBCEA933C297A19313F62AC75"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 7, "Domain": 1, "Region": 3, "Compositional bias": 3}, "uniParcId": "UPI003251C556"}, "cluster_size": 1, "family": "Tarsonemidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7LJG4", "uniProtkbId": "A0AAU7LJG4_9ROSA", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Hippophae rhamnoides", "taxonId": 193516, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28240.1"}], "lineage": ["Eukaryota", "Viridiplantae", "Streptophyta", "Embryophyta", "Tracheophyta", "Spermatophyta", "Magnoliopsida", "eudicotyledons", "Gunneridae", "Pentapetalae", "rosids", "fabids", "Rosales", "Elaeagnaceae", "Hippophae"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28240.1"}], "value": "MADS45"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28240.1"}], "value": "MADS45"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 5, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "MADS-box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50066"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023163"}], "id": "KW-0804", "category": "Biological process", "name": "Transcription"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023015"}], "id": "KW-0805", "category": "Biological process", "name": "Transcription regulation"}], "references": [{"referenceNumber": 1, "citation": {"id": "38938643", "citationType": "journal article", "authors": ["Zhao J.", "Xu Y.", "Zhang Z.", "Zhao M.", "Li K.", "Wang F.", "Sun K."], "citationCrossReferences": [{"database": "PubMed", "id": "38938643"}], "title": "Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.", "publicationDate": "2024", "journal": "Front. Plant Sci.", "firstPage": "0", "lastPage": "0", "volume": "15"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28240.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-8JPP82579JUM7", "citationType": "submission", "authors": ["Xu Y.", "Zhao J."], "publicationDate": "FEB-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBP28240.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "PP400880", "properties": [{"key": "ProteinId", "value": "XBP28240.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0000981", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0045944", "properties": [{"key": "GoTerm", "value": "P:positive regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd00266", "properties": [{"key": "EntryName", "value": "MADS_SRF_like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "3.40.1810.10", "properties": [{"key": "EntryName", "value": "Transcription factor, MADS-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR033897", "properties": [{"key": "EntryName", "value": "SRF-like_MADS-box"}]}, {"database": "InterPro", "id": "IPR002100", "properties": [{"key": "EntryName", "value": "TF_MADSbox"}]}, {"database": "InterPro", "id": "IPR036879", "properties": [{"key": "EntryName", "value": "TF_MADSbox_sf"}]}, {"database": "PANTHER", "id": "PTHR11945", "properties": [{"key": "EntryName", "value": "MADS BOX PROTEIN"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR11945:SF534", "properties": [{"key": "EntryName", "value": "MYOCYTE-SPECIFIC ENHANCER FACTOR 2"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00319", "properties": [{"key": "EntryName", "value": "SRF-TF"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00404", "properties": [{"key": "EntryName", "value": "MADSDOMAIN"}]}, {"database": "SMART", "id": "SM00432", "properties": [{"key": "EntryName", "value": "MADS"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF55455", "properties": [{"key": "EntryName", "value": "SRF-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50066", "properties": [{"key": "EntryName", "value": "MADS_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MNINMGRGKQKMELIADEKSRRTTFQKRKKGLMKKAYEFSTLCDVDVCIIIYGPSKQEDEVHTWPTDPNEVKRIVGKYYSITKSKPAYNVVNVFDIMSDRKRRIDADISKLRKAFYAAKYPTWHQSLDYFSNYELDLLLNRMNPNIEALDRYTVDKTHRVKLNIRNVVVVVDLVGRSMRAGQISNFVLKRSLNQSPFMVS", "length": 200, "molWeight": 23366, "crc64": "84654DADB4B53D65", "md5": "7C8C3F8AA3BD1446EF3AB0FBAF870770"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1}, "uniParcId": "UPI0035D2E761"}, "cluster_size": 1, "family": "Elaeagnaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA82WPD0", "uniProtkbId": "A0AA82WPD0_9EURO", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Penicillium virgatum", "taxonId": 282147, "evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8B2G"}], "lineage": ["Eukaryota", "Fungi", "Dikarya", "Ascomycota", "Pezizomycotina", "Eurotiomycetes", "Eurotiomycetidae", "Eurotiales", "Aspergillaceae", "Penicillium"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "PDB", "id": "8B2G"}], "value": "SH3b domain-containing protein"}}]}, "features": [{"type": "Binding site", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8B2G"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105"}}, {"type": "Binding site", "location": {"start": {"value": 29, "modifier": "EXACT"}, "end": {"value": 29, "modifier": "EXACT"}}, "description": "", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:29105"}], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8B2G"}], "ligand": {"name": "Zn(2+)", "id": "ChEBI:CHEBI:29105"}}, {"type": "Disulfide bond", "location": {"start": {"value": 10, "modifier": "EXACT"}, "end": {"value": 54, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8B2G"}]}, {"type": "Disulfide bond", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 73, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8B2G"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8B2G"}], "id": "KW-0002", "category": "Technical term", "name": "3D-structure"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8B2G"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8B2G"}], "id": "KW-0862", "category": "Ligand", "name": "Zinc"}], "references": [{"referenceNumber": 1, "citation": {"id": "37428847", "citationType": "journal article", "authors": ["Moroz O.V.", "Blagova E.", "Lebedev A.A.", "Skov L.K.", "Pache R.A.", "Schnorr K.M.", "Kiemer L.", "Friis E.P.", "Nymand-Grarup S.", "Ming L.", "Ye L.", "Klausen M.", "Cohn M.T.", "Schmidt E.G.W.", "Davies G.J.", "Wilson K.S."], "citationCrossReferences": [{"database": "PubMed", "id": "37428847"}, {"database": "DOI", "id": "10.1107/s2059798323005004"}], "title": "Module walking using an SH3-like cell-wall-binding domain leads to a new GH184 family of muramidases.", "publicationDate": "2023", "journal": "Acta Crystallogr. D Struct. Biol.", "firstPage": "706", "lastPage": "720", "volume": "79"}, "referencePositions": ["X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH ZN(2+)", "DISULFIDE BONDS"], "evidences": [{"evidenceCode": "ECO:0007829", "source": "PDB", "id": "8B2G"}]}], "uniProtKBCrossReferences": [{"database": "PDB", "id": "8B2G", "properties": [{"key": "Method", "value": "X-ray"}, {"key": "Resolution", "value": "1.50 A"}, {"key": "Chains", "value": "A/B=1-74"}]}, {"database": "SMR", "id": "A0AA82WPD0", "properties": [{"key": "Description", "value": "-"}]}, {"database": "GO", "id": "GO:0046872", "properties": [{"key": "GoTerm", "value": "F:metal ion binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "2.30.30.40", "properties": [{"key": "EntryName", "value": "SH3 Domains"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "YPITGDGVNCRSGPGTSYSVVKSYQKGADVAITCQAPGTDVKGDNIWDKTADGCYVADYYIKTGSSSYVTAKCD", "length": 74, "molWeight": 7785, "crc64": "3118FC1063C1AC85", "md5": "375D3263917EF137DC06D478A4A4B88F"}, "extraAttributes": {"countByFeatureType": {"Binding site": 2, "Disulfide bond": 2}, "uniParcId": "UPI002657644E"}, "cluster_size": 3, "family": "Aspergillaceae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU0QLU0", "uniProtkbId": "A0AAU0QLU0_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Leucinodes orbonalis", "taxonId": 711050, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56495.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Pyraloidea", "Crambidae", "Spilomelinae", "Leucinodes"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56495.1"}], "value": "Odorant receptor"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 32, "modifier": "EXACT"}, "end": {"value": 55, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 67, "modifier": "EXACT"}, "end": {"value": 85, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 126, "modifier": "EXACT"}, "end": {"value": 149, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 170, "modifier": "EXACT"}, "end": {"value": 187, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56495.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}, {"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56495.1"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-C52SCS9G4VRQU", "citationType": "submission", "authors": ["Pathak J.", "Thiruvengadam V.", "Gracy G.R.", "M M."], "publicationDate": "MAY-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56495.1"}], "value": "Head and antenna", "type": "TISSUE"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WPO56495.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OQ970388", "properties": [{"key": "ProteinId", "value": "WPO56495.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "GTKRSDVFRINRFFWKIFALWPGKHPTKCYKYYSVVFLIIVNVVYNLLLSVNLFCTPHNVQAFIEEALFFFTELAAMTKMIMIITKREKIIALFKIINCKEFQGRNQVDKTIIANSDSKYKICWKLYALTSNFSYFGIVFIPVILHFVFKTDLKLPIAKYYFLSDATKEKYFILLFIYQSIGIYVHMTYNVNIDSFMAGMIFVGVSELKILNHNFSQLNLRSVKNKNKAIAENMKMMELNKVLLHYDLIIRY", "length": 252, "molWeight": 29733, "crc64": "3A1DBA60252772DC", "md5": "834CEF1BB2A071B689C750DE55EB9BC6"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 4, "Non-terminal residue": 1}, "uniParcId": "UPI0030901F13"}, "cluster_size": 1, "family": "Crambidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAF0T3E3", "uniProtkbId": "A0AAF0T3E3_9EUCA", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-02-05", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Tenuipotamon panxiense", "taxonId": 2841827, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59175.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Crustacea", "Multicrustacea", "Malacostraca", "Eumalacostraca", "Eucarida", "Decapoda", "Pleocyemata", "Brachyura", "Eubrachyura", "Potamoidea", "Potamidae", "Tenuipotamon"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59175.1"}], "value": "Mediator of RNA polymerase II transcription subunit 15-like protein"}}], "flag": "Fragment"}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59175.1"}], "value": "C144422636"}}], "features": [{"type": "Domain", "location": {"start": {"value": 15, "modifier": "EXACT"}, "end": {"value": 128, "modifier": "EXACT"}}, "description": "ARC105/Med15 mediator subunit central", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF21538"}]}, {"type": "Domain", "location": {"start": {"value": 159, "modifier": "EXACT"}, "end": {"value": 267, "modifier": "EXACT"}}, "description": "ARC105/Med15 mediator subunit C-terminal", "evidences": [{"evidenceCode": "ECO:0000259", "source": "Pfam", "id": "PF21539"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59175.1"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 281, "modifier": "EXACT"}, "end": {"value": 281, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59175.1"}]}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1DUD5B4DAK3CB", "citationType": "submission", "authors": ["Shi B.", "Pan D.", "Sun H."], "publicationDate": "SEP-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59175.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59175.1"}]}, {"referenceNumber": 2, "citation": {"id": "37898294", "citationType": "journal article", "authors": ["Shi B.Y.", "Pan D.", "Zhang K.Q.", "Gu T.Y.", "Yeo D.C.J.", "Ng P.K.L.", "Cumberlidge N.", "Sun H.Y."], "citationCrossReferences": [{"database": "PubMed", "id": "37898294"}], "title": "Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.", "publicationDate": "2024", "journal": "Mol. Phylogenet. Evol.", "firstPage": "0", "lastPage": "0", "volume": "190"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59175.1"}], "value": "HNCZY", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WMS59175.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR515298", "properties": [{"key": "ProteinId", "value": "WMS59175.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "InterPro", "id": "IPR048386", "properties": [{"key": "EntryName", "value": "Med15_C"}]}, {"database": "InterPro", "id": "IPR048385", "properties": [{"key": "EntryName", "value": "Med15_central"}]}, {"database": "PANTHER", "id": "PTHR31804", "properties": [{"key": "EntryName", "value": "MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR31804:SF3", "properties": [{"key": "EntryName", "value": "MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF21539", "properties": [{"key": "EntryName", "value": "Med15_C"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF21538", "properties": [{"key": "EntryName", "value": "Med15_M"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "QQPSPAPVMSSSQVEEAAYMEKLRRLKKYVVPLGRMIQRIGNDDGEKSKKMKQLYDMLQNPTRRMPMETLIKCEKVLERLEIQRDNEAEAPVPPSMETCTAALEEVLATVLKSPCAAHTLHRTLSPALSVLLGPTYSTHPATLAPASRPLQPPPETPDISDIVQGEVARLNARFRINLDCQMPPGSDELTLICQLDDPNLPCVPPITLTVPASYPDKPPRCHLLAVDYESTEFLRSIRESMSERLQSMPPHCSLTMMLHSWEMSVRQACSPQPPLISTIAS", "length": 281, "molWeight": 31285, "crc64": "C7223A5221722E66", "md5": "9F101F49BE9B6602A1B8B659125D7ACB"}, "extraAttributes": {"countByFeatureType": {"Domain": 2, "Non-terminal residue": 2}, "uniParcId": "UPI002B2D52E7"}, "cluster_size": 14, "family": "Potamidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9FG50", "uniProtkbId": "A0AAT9FG50_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Enchytraeus japonensis", "taxonId": 228735, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61264.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61264.1"}], "value": "Transcription factor SoxC"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61264.1"}], "value": "Ej-soxC"}}], "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004123"}], "value": "Nucleus", "id": "SL-0191"}}]}], "features": [{"type": "Domain", "location": {"start": {"value": 87, "modifier": "EXACT"}, "end": {"value": 155, "modifier": "EXACT"}}, "description": "HMG box", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50118"}]}, {"type": "DNA binding", "location": {"start": {"value": 87, "modifier": "EXACT"}, "end": {"value": 155, "modifier": "EXACT"}}, "description": "HMG box", "evidences": [{"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00267"}]}, {"type": "Region", "location": {"start": {"value": 161, "modifier": "EXACT"}, "end": {"value": 180, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 204, "modifier": "EXACT"}, "end": {"value": 235, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Region", "location": {"start": {"value": 265, "modifier": "EXACT"}, "end": {"value": 285, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 216, "modifier": "EXACT"}, "end": {"value": 235, "modifier": "EXACT"}}, "description": "Basic and acidic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00267"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023242"}, {"evidenceCode": "ECO:0000256", "source": "PROSITE-ProRule", "id": "PRU00267"}], "id": "KW-0539", "category": "Cellular component", "name": "Nucleus"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-1NS4NNSF9REKQ", "citationType": "submission", "authors": ["Yamaguchi S.", "Fujita T."], "title": "Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.", "publicationDate": "JUN-2024", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "BDR61264.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "LC727637", "properties": [{"key": "ProteinId", "value": "BDR61264.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005634", "properties": [{"key": "GoTerm", "value": "C:nucleus"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0001228", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription activator activity, RNA polymerase II-specific"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000978", "properties": [{"key": "GoTerm", "value": "F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0007420", "properties": [{"key": "GoTerm", "value": "P:brain development"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0000122", "properties": [{"key": "GoTerm", "value": "P:negative regulation of transcription by RNA polymerase II"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0030182", "properties": [{"key": "GoTerm", "value": "P:neuron differentiation"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd22029", "properties": [{"key": "EntryName", "value": "HMG-box_SoxC"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.30.10:FF:000007", "properties": [{"key": "EntryName", "value": "Transcription factor SOX"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.30.10", "properties": [{"key": "EntryName", "value": "High mobility group box domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR009071", "properties": [{"key": "EntryName", "value": "HMG_box_dom"}]}, {"database": "InterPro", "id": "IPR036910", "properties": [{"key": "EntryName", "value": "HMG_box_dom_sf"}]}, {"database": "InterPro", "id": "IPR050140", "properties": [{"key": "EntryName", "value": "SRY-related_HMG-box_TF-like"}]}, {"database": "PANTHER", "id": "PTHR10270", "properties": [{"key": "EntryName", "value": "SOX TRANSCRIPTION FACTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR10270:SF323", "properties": [{"key": "EntryName", "value": "TRANSCRIPTION FACTOR SOX-14-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00505", "properties": [{"key": "EntryName", "value": "HMG_box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00398", "properties": [{"key": "EntryName", "value": "HMG"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47095", "properties": [{"key": "EntryName", "value": "HMG-box"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50118", "properties": [{"key": "EntryName", "value": "HMG_BOX_2"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MILSSKIYDMEELYIDSVDSGSEVSLFDESQSSPPLSHSPLVLMTHQPFLMDPAQLYGSQFGSQKVDPNSATPYSDATQCKKPTNHIKRPMNAFMVWSQIERRRIVEFQPDLHNAIISKQLGKRWKTLSEEERQPFVEEAERLRLLHLKEYPDYKYRPRKRSAVGSAPGGAEMASEVKGEPNAKVRKELVSLKSKLNSSKIVNSQRKIAPAVKSKVGKEPPRYEHSRPQARLERSSAKISSWSVNMESNGGVWSKRSGSIRIGMPSTTKVPSSPGVLGAPDTPDSASFYPEDRLVTGSSFGTMHQLEIVPEGSSLYLSMLDSPPSSLTGALSCDELNQGSRYAEIACSEVDSTCNLGTVISNFNDHDIKPFSNNNNLFVNNNVIISNDINGNNNIINYSNGYENVKQEYEPYLASALTPVKTPERKASIKDEYIVLSDLTSGGHLIEKGLVWNSSSSTLLPSPRFISVISFISVE", "length": 475, "molWeight": 52600, "crc64": "DF5EEC417EA57D74", "md5": "89965BB458C65C07A591CE09EABAC58A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Domain": 1, "DNA binding": 1, "Region": 3, "Compositional bias": 1}, "uniParcId": "UPI0035D3579E"}, "cluster_size": 1, "family": "Enchytraeidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AA96MPM3", "uniProtkbId": "A0AA96MPM3_HALDU", "entryAudit": {"firstPublicDate": "2024-03-27", "lastAnnotationUpdateDate": "2024-07-24", "lastSequenceUpdateDate": "2024-03-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Halisarca dujardinii", "commonName": "Dujardin's slime sponge", "taxonId": 2583056, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50079.1"}], "lineage": ["Eukaryota", "Metazoa", "Porifera", "Demospongiae", "Verongimorpha", "Chondrillida", "Halisarcidae", "Halisarca"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50079.1"}], "value": "Uncharacterized protein 17"}}]}, "features": [{"type": "Transmembrane", "location": {"start": {"value": 6, "modifier": "EXACT"}, "end": {"value": 22, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 34, "modifier": "EXACT"}, "end": {"value": 57, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 69, "modifier": "EXACT"}, "end": {"value": 96, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 108, "modifier": "EXACT"}, "end": {"value": 128, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 164, "modifier": "EXACT"}, "end": {"value": 186, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 207, "modifier": "EXACT"}, "end": {"value": 229, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 235, "modifier": "EXACT"}, "end": {"value": 257, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-7DD4EIHLI067", "citationType": "submission", "authors": ["Adameyko K.", "Kravchuk O.", "Lyupina Y."], "publicationDate": "AUG-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WNS50079.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR460156", "properties": [{"key": "ProteinId", "value": "WNS50079.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0016020", "properties": [{"key": "GoTerm", "value": "C:membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "Gene3D", "id": "1.20.1070.10", "properties": [{"key": "EntryName", "value": "Rhodopsin 7-helix transmembrane proteins"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF81321", "properties": [{"key": "EntryName", "value": "Family A G protein-coupled receptor-like"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MMLFVLFAMVITTIVGLYRAKSLEKMLKVFLANLLVSVLATGLVMLVLLLLTQVLIFSSAPRDLHICRVLIWGLLSCSGVRFFSLTANSLLTLLVVVHGKKKIRKSWIFTLLASIWFVPVLIHLYILIPVVYPVFYYGNFGCFPLNEDSNGLATVRLVSSSLSIIASSVIPLIMCVVMPSVMFCYLRQNTMSAHRASYNKGLAKLALFLITGNFLNFAGLVLITIVAYASQEAAGYLLCIFWVVCLFPTPCFVYLYLKPVREAINTMLCPWRLHSGVIPVASSSSASHQQTSSISPPSNRPI", "length": 302, "molWeight": 33436, "crc64": "DB544E569559A38E", "md5": "6090022C22EEE8FC33EF05DE846ACB24"}, "extraAttributes": {"countByFeatureType": {"Transmembrane": 7}, "uniParcId": "UPI002B2D46CC"}, "cluster_size": 1, "family": "Halisarcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU6ND31", "uniProtkbId": "A0AAU6ND31_9NEOP", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 5, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mythimna loreyi", "taxonId": 667449, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59776.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Endopterygota", "Lepidoptera", "Glossata", "Ditrysia", "Noctuoidea", "Noctuidae", "Hadeninae", "Mythimna"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59776.1"}], "value": "OR8b"}}], "flag": "Fragment"}, "comments": [{"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Cell membrane", "id": "SL-0039"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004651"}], "value": "Multi-pass membrane protein", "id": "SL-9909"}}]}], "features": [{"type": "Transmembrane", "location": {"start": {"value": 46, "modifier": "EXACT"}, "end": {"value": 65, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 180, "modifier": "EXACT"}, "end": {"value": 199, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 205, "modifier": "EXACT"}, "end": {"value": 223, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Transmembrane", "location": {"start": {"value": 272, "modifier": "EXACT"}, "end": {"value": 295, "modifier": "EXACT"}}, "description": "Helical", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}]}, {"type": "Non-terminal residue", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 1, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59776.1"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022475"}], "id": "KW-1003", "category": "Cellular component", "name": "Cell membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022725"}], "id": "KW-0552", "category": "Biological process", "name": "Olfaction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023170"}], "id": "KW-0675", "category": "Molecular function", "name": "Receptor"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022606"}], "id": "KW-0716", "category": "Biological process", "name": "Sensory transduction"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023224"}], "id": "KW-0807", "category": "Molecular function", "name": "Transducer"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022692"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-0812", "category": "Domain", "name": "Transmembrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022989"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Phobius"}], "id": "KW-1133", "category": "Domain", "name": "Transmembrane helix"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-5A0EM62O2RCVB", "citationType": "submission", "authors": ["Zhang Y.-y.", "Guo J.-M."], "title": "Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.", "publicationDate": "MAY-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WWA59776.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "ON420136", "properties": [{"key": "ProteinId", "value": "WWA59776.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005886", "properties": [{"key": "GoTerm", "value": "C:plasma membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004984", "properties": [{"key": "GoTerm", "value": "F:olfactory receptor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007165", "properties": [{"key": "GoTerm", "value": "P:signal transduction"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "InterPro", "id": "IPR004117", "properties": [{"key": "EntryName", "value": "7tm6_olfct_rcpt"}]}, {"database": "PANTHER", "id": "PTHR21137", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR21137:SF35", "properties": [{"key": "EntryName", "value": "ODORANT RECEPTOR 19A-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF02949", "properties": [{"key": "EntryName", "value": "7tm_6"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "FARNRLVWIMELRQIDYFKIQVQFWRFLGIWPGHHVSRSYNYYSKAFTTTFVFVYIVLFSINFYFLPKQLDIFINDMLFYFTDCSVLSKVLTYLLMRKKIIAILDVLESETFQPDDAEGRTIIAKAKKFNKMYWNVVAVVSFTSSCIHTLSDFILHVLKGKELTFPVCSYAFFPGSFRRMFVYPIYFYQCVGIIFHMFYNLNVDTFFLGLLVFIIAQLDILDVKLRKVTDKNMHDDADGETIDENKESVMKINKCILHFDEVGKFCNLVQEVFSVTLFVQFSMASCIICVCLMRFTMVRKL", "length": 301, "molWeight": 35564, "crc64": "0F69FBB898060DA2", "md5": "CBE308D2F35E536C0095063674536D7A"}, "extraAttributes": {"countByCommentType": {"SUBCELLULAR LOCATION": 1}, "countByFeatureType": {"Transmembrane": 4, "Non-terminal residue": 1}, "uniParcId": "UPI0035D377AE"}, "cluster_size": 1, "family": "Noctuidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9UU42", "uniProtkbId": "A0AAT9UU42_MACHI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-06-18", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 2.0, "organism": {"scientificName": "Maconellicoccus hirsutus", "commonName": "Pink hibiscus mealybug", "taxonId": 177089, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41644.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Sternorrhyncha", "Coccoidea", "Pseudococcidae", "Maconellicoccus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41644.1"}], "value": "Cytochrome P450 6AEC1"}}]}, "comments": [{"commentType": "COFACTOR", "cofactors": [{"name": "heme", "evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00001971"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "cofactorCrossReference": {"database": "ChEBI", "id": "CHEBI:30413"}}]}, {"commentType": "SUBCELLULAR LOCATION", "subcellularLocations": [{"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Endoplasmic reticulum membrane", "id": "SL-0097"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004406"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}, {"location": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Microsome membrane", "id": "SL-0165"}, "topology": {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00004174"}], "value": "Peripheral membrane protein", "id": "SL-9903"}}]}, {"texts": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00010617"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "value": "Belongs to the cytochrome P450 family"}], "commentType": "SIMILARITY"}], "features": [{"type": "Binding site", "location": {"start": {"value": 396, "modifier": "EXACT"}, "end": {"value": 396, "modifier": "EXACT"}}, "description": "axial binding residue", "featureCrossReferences": [{"database": "ChEBI", "id": "CHEBI:30413"}, {"database": "ChEBI", "id": "CHEBI:18248"}], "evidences": [{"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "ligand": {"name": "heme", "id": "ChEBI:CHEBI:30413"}, "ligandPart": {"name": "Fe", "id": "ChEBI:CHEBI:18248"}}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022824"}], "id": "KW-0256", "category": "Cellular component", "name": "Endoplasmic reticulum"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022617"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0349", "category": "Ligand", "name": "Heme"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023004"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0408", "category": "Ligand", "name": "Iron"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023136"}], "id": "KW-0472", "category": "Cellular component", "name": "Membrane"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022723"}, {"evidenceCode": "ECO:0000256", "source": "PIRSR", "id": "PIRSR602401-1"}], "id": "KW-0479", "category": "Ligand", "name": "Metal-binding"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022848"}], "id": "KW-0492", "category": "Cellular component", "name": "Microsome"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023033"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0503", "category": "Molecular function", "name": "Monooxygenase"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023002"}, {"evidenceCode": "ECO:0000256", "source": "RuleBase", "id": "RU000461"}], "id": "KW-0560", "category": "Molecular function", "name": "Oxidoreductase"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-F5VCBISJIF9V0", "citationType": "submission", "authors": ["Selvamani S.B.", "Negi N.", "Nagarjuna Reddy K.V.", "Ramasamy G.G."], "title": "Identification of Cytochrome P450s in Maconellicoccus hirsutus.", "publicationDate": "JUN-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WIM41644.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR117204", "properties": [{"key": "ProteinId", "value": "WIM41644.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005789", "properties": [{"key": "GoTerm", "value": "C:endoplasmic reticulum membrane"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-SubCell"}]}, {"database": "GO", "id": "GO:0020037", "properties": [{"key": "GoTerm", "value": "F:heme binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0005506", "properties": [{"key": "GoTerm", "value": "F:iron ion binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0004497", "properties": [{"key": "GoTerm", "value": "F:monooxygenase activity"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0016705", "properties": [{"key": "GoTerm", "value": "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11056", "properties": [{"key": "EntryName", "value": "CYP6-like"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "1.10.630.10:FF:000182", "properties": [{"key": "EntryName", "value": "Cytochrome P450 3A4"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.630.10", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR001128", "properties": [{"key": "EntryName", "value": "Cyt_P450"}]}, {"database": "InterPro", "id": "IPR017972", "properties": [{"key": "EntryName", "value": "Cyt_P450_CS"}]}, {"database": "InterPro", "id": "IPR002401", "properties": [{"key": "EntryName", "value": "Cyt_P450_E_grp-I"}]}, {"database": "InterPro", "id": "IPR036396", "properties": [{"key": "EntryName", "value": "Cyt_P450_sf"}]}, {"database": "InterPro", "id": "IPR050476", "properties": [{"key": "EntryName", "value": "Insect_CytP450_Detox"}]}, {"database": "PANTHER", "id": "PTHR24292:SF54", "properties": [{"key": "EntryName", "value": "CYP9F3-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PANTHER", "id": "PTHR24292", "properties": [{"key": "EntryName", "value": "CYTOCHROME P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00067", "properties": [{"key": "EntryName", "value": "p450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00463", "properties": [{"key": "EntryName", "value": "EP450I"}]}, {"database": "PRINTS", "id": "PR00385", "properties": [{"key": "EntryName", "value": "P450"}]}, {"database": "SUPFAM", "id": "SSF48264", "properties": [{"key": "EntryName", "value": "Cytochrome P450"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS00086", "properties": [{"key": "EntryName", "value": "CYTOCHROME_P450"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MAEAVLMKKRVFMAYADLYAKFGHSKYVGFFTMQKPSVLIRDPSIIKDVLIKEFSNFHHRGITVNAQVEPITNHLFSMRGEEWKTSRVKLSSAFATGKIKILFPRMQKIAERLQVELANVANGQDFDVEALCERFCIDAIGSCIFGIDINSLDHPESEFRFIAKRVASFRYQRAIRSLWPGIPNKLIELFKITLFEDRFRTFFTKVVEDTMKQRESTLHRSDFFNALLSLKNASKLDTVQQKLDMMAAQYFFFFTTGSRSPATSITCALFELSRHEEIQNKTRLEIRTVLQNNQGQLTYDILSKMTYTDMVIAETLRKYPTMGMLLRRSTQNYHVPSTDSVIPNNTSIVISIVGLHNDKKYYERPDQFYPEHFTEEAKSKRPQYTFIPFGEGPRACIAKHFAKLQVKIGLIYMLLNHKYEVSPKQKLPFKLQSNFGFAIEDGVWLRCRKID", "length": 451, "molWeight": 52331, "crc64": "12B9548AE87A0B79", "md5": "F1F3B258D934D745372CEC9239828313"}, "extraAttributes": {"countByCommentType": {"COFACTOR": 1, "SUBCELLULAR LOCATION": 1, "SIMILARITY": 1}, "countByFeatureType": {"Binding site": 1}, "uniParcId": "UPI0035D2849C"}, "cluster_size": 2, "family": "Pseudococcidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAA9WUT3", "uniProtkbId": "A0AAA9WUT3_MOUSE", "entryAudit": {"firstPublicDate": "2024-05-29", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-05-29", "entryVersion": 8, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Mus musculus", "commonName": "Mouse", "taxonId": 10090, "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159932.1"}, {"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "lineage": ["Eukaryota", "Metazoa", "Chordata", "Craniata", "Vertebrata", "Euteleostomi", "Mammalia", "Eutheria", "Euarchontoglires", "Glires", "Rodentia", "Myomorpha", "Muroidea", "Muridae", "Murinae", "Mus", "Mus"]}, "proteinExistence": "1: Evidence at protein level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159932.1"}], "value": "TSR3 20S rRNA accumulation"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159932.1"}, {"evidenceCode": "ECO:0000313", "source": "MGI", "id": "MGI:1915577"}], "value": "Tsr3"}}], "features": [{"type": "Region", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 25, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0007829", "source": "PeptideAtlas", "id": "A0AAA9WUT3"}, {"evidenceCode": "ECO:0007829", "source": "ProteomicsDB", "id": "A0AAA9WUT3"}], "id": "KW-1267", "category": "Technical term", "name": "Proteomics identification"}, {"evidences": [{"evidenceCode": "ECO:0000313", "source": "Proteomes", "id": "UP000000589"}], "id": "KW-1185", "category": "Technical term", "name": "Reference proteome"}], "references": [{"referenceNumber": 1, "citation": {"id": "19468303", "citationType": "journal article", "authoringGroup": ["Mouse Genome Sequencing Consortium"], "authors": ["Church D.M.", "Goodstadt L.", "Hillier L.W.", "Zody M.C.", "Goldstein S.", "She X.", "Bult C.J.", "Agarwala R.", "Cherry J.L.", "DiCuccio M.", "Hlavina W.", "Kapustin Y.", "Meric P.", "Maglott D.", "Birtle Z.", "Marques A.C.", "Graves T.", "Zhou S.", "Teague B.", "Potamousis K.", "Churas C.", "Place M.", "Herschleb J.", "Runnheim R.", "Forrest D.", "Amos-Landgraf J.", "Schwartz D.C.", "Cheng Z.", "Lindblad-Toh K.", "Eichler E.E.", "Ponting C.P."], "citationCrossReferences": [{"database": "PubMed", "id": "19468303"}, {"database": "DOI", "id": "10.1371/journal.pbio.1000112"}], "title": "Lineage-specific biology revealed by a finished genome assembly of the mouse.", "publicationDate": "2009", "journal": "PLoS Biol.", "firstPage": "e1000112", "lastPage": "e1000112", "volume": "7"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159932.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159932.1"}]}, {"referenceNumber": 2, "citation": {"id": "21750661", "citationType": "journal article", "authors": ["Church D.M.", "Schneider V.A.", "Graves T.", "Auger K.", "Cunningham F.", "Bouk N.", "Chen H.C.", "Agarwala R.", "McLaren W.M.", "Ritchie G.R.", "Albracht D.", "Kremitzki M.", "Rock S.", "Kotkiewicz H.", "Kremitzki C.", "Wollam A.", "Trani L.", "Fulton L.", "Fulton R.", "Matthews L.", "Whitehead S.", "Chow W.", "Torrance J.", "Dunn M.", "Harden G.", "Threadgold G.", "Wood J.", "Collins J.", "Heath P.", "Griffiths G.", "Pelan S.", "Grafham D.", "Eichler E.E.", "Weinstock G.", "Mardis E.R.", "Wilson R.K.", "Howe K.", "Flicek P.", "Hubbard T."], "citationCrossReferences": [{"database": "PubMed", "id": "21750661"}], "title": "Modernizing reference genome assemblies.", "publicationDate": "2011", "journal": "PLoS Biol.", "firstPage": "e1001091", "lastPage": "e1001091", "volume": "9"}, "referencePositions": ["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159932.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159932.1"}]}, {"referenceNumber": 3, "citation": {"id": "CI-20IMVO6BKU264", "citationType": "submission", "authoringGroup": ["Ensembl"], "publicationDate": "MAY-2025", "submissionDatabase": "UniProtKB"}, "referencePositions": ["IDENTIFICATION"], "referenceComments": [{"evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159932.1"}], "value": "C57BL/6J", "type": "STRAIN"}], "evidences": [{"evidenceCode": "ECO:0000313", "source": "Ensembl", "id": "ENSMUSP00000159932.1"}]}], "uniProtKBCrossReferences": [{"database": "SMR", "id": "A0AAA9WUT3", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Ensembl", "id": "ENSMUST00000249827.1", "properties": [{"key": "ProteinId", "value": "ENSMUSP00000159932.1"}, {"key": "GeneId", "value": "ENSMUSG00000015126.11"}]}, {"database": "AGR", "id": "MGI:1915577", "properties": [{"key": "Description", "value": "-"}]}, {"database": "MGI", "id": "MGI:1915577", "properties": [{"key": "GeneName", "value": "Tsr3"}]}, {"database": "GeneTree", "id": "ENSGT00390000014665", "properties": [{"key": "Description", "value": "-"}]}, {"database": "Proteomes", "id": "UP000000589", "properties": [{"key": "Component", "value": "Chromosome 17"}]}], "sequence": {"value": "MGRKKVARGSRKESGRVRRPSGRSLDAFAEEVGAALRDSWWHSQGSQS", "length": 48, "molWeight": 5329, "crc64": "E46E07CD06632569", "md5": "74F4DE32B0672DC0C68CE9B9217B5E90"}, "extraAttributes": {"countByFeatureType": {"Region": 1}, "uniParcId": "UPI002B500E70"}, "cluster_size": 2, "family": "Muridae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAT9TZ71", "uniProtkbId": "A0AAT9TZ71_9HEMI", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-10-08", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 4, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Eocanthecona furcellata", "taxonId": 696902, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83456.1"}], "lineage": ["Eukaryota", "Metazoa", "Ecdysozoa", "Arthropoda", "Hexapoda", "Insecta", "Pterygota", "Neoptera", "Paraneoptera", "Hemiptera", "Heteroptera", "Panheteroptera", "Pentatomomorpha", "Pentatomoidea", "Pentatomidae", "Asopinae", "Eocanthecona"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83456.1"}], "value": "Odorant-binding protein 8"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83456.1"}], "value": "OBP8"}}], "features": [{"type": "Signal", "location": {"start": {"value": 1, "modifier": "EXACT"}, "end": {"value": 23, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}]}, {"type": "Chain", "location": {"start": {"value": 24, "modifier": "EXACT"}, "end": {"value": 152, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "featureId": "PRO_5043625120"}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00022729"}, {"evidenceCode": "ECO:0000256", "source": "SAM", "id": "SignalP"}], "id": "KW-0732", "category": "Domain", "name": "Signal"}], "references": [{"referenceNumber": 1, "citation": {"id": "CI-4EEV3RJ5PT5SU", "citationType": "submission", "authors": ["Pan Y.", "Chen W."], "publicationDate": "OCT-2022", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "WGJ83456.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OP575935", "properties": [{"key": "ProteinId", "value": "WGJ83456.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0005615", "properties": [{"key": "GoTerm", "value": "C:extracellular space"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "GO", "id": "GO:0005549", "properties": [{"key": "GoTerm", "value": "F:odorant binding"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0007608", "properties": [{"key": "GoTerm", "value": "P:sensory perception of smell"}, {"key": "GoEvidenceType", "value": "IEA:TreeGrafter"}]}, {"database": "CDD", "id": "cd23992", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "1.10.238.20", "properties": [{"key": "EntryName", "value": "Pheromone/general odorant binding protein domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR006170", "properties": [{"key": "EntryName", "value": "PBP/GOBP"}]}, {"database": "InterPro", "id": "IPR036728", "properties": [{"key": "EntryName", "value": "PBP_GOBP_sf"}]}, {"database": "PANTHER", "id": "PTHR11857", "properties": [{"key": "EntryName", "value": "ODORANT BINDING PROTEIN-RELATED"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF01395", "properties": [{"key": "EntryName", "value": "PBP_GOBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SMART", "id": "SM00708", "properties": [{"key": "EntryName", "value": "PhBP"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47565", "properties": [{"key": "EntryName", "value": "Insect pheromone/odorant-binding proteins"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MKFFTVVVLTLVIFTTSLVLIECQEDEVMKLQKEAMTQCTEEHPISQEAIKSIVNREHVPDDPEVKCWIRCAYEKLGVMKDGKLDWDRCNFLTKHCLDNDEDKAKVDRITEICRLEVSNDEEDKCQLAYIGTVCKIDNWKKLGLPAMKLIER", "length": 152, "molWeight": 17668, "crc64": "B3F7E546C208261B", "md5": "8776D1447043D52E55CB52E5A7285781"}, "extraAttributes": {"countByFeatureType": {"Signal": 1, "Chain": 1}, "uniParcId": "UPI0035D360B4"}, "cluster_size": 1, "family": "Pentatomidae"}
{"entryType": "UniProtKB unreviewed (TrEMBL)", "primaryAccession": "A0AAU7VFF7", "uniProtkbId": "A0AAU7VFF7_9ANNE", "entryAudit": {"firstPublicDate": "2024-11-27", "lastAnnotationUpdateDate": "2025-04-02", "lastSequenceUpdateDate": "2024-11-27", "entryVersion": 3, "sequenceVersion": 1}, "annotationScore": 1.0, "organism": {"scientificName": "Enchytraeus coronatus", "taxonId": 208440, "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67475.1"}], "lineage": ["Eukaryota", "Metazoa", "Spiralia", "Lophotrochozoa", "Annelida", "Clitellata", "Oligochaeta", "Enchytraeida", "Enchytraeidae", "Enchytraeus"]}, "proteinExistence": "2: Evidence at transcript level", "proteinDescription": {"submissionNames": [{"fullName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67475.1"}], "value": "Transcriptional regulator Myc"}}]}, "genes": [{"geneName": {"evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67475.1"}], "value": "myc"}}], "features": [{"type": "Domain", "location": {"start": {"value": 339, "modifier": "EXACT"}, "end": {"value": 391, "modifier": "EXACT"}}, "description": "BHLH", "evidences": [{"evidenceCode": "ECO:0000259", "source": "PROSITE", "id": "PS50888"}]}, {"type": "Region", "location": {"start": {"value": 224, "modifier": "EXACT"}, "end": {"value": 334, "modifier": "EXACT"}}, "description": "Disordered", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Coiled coil", "location": {"start": {"value": 392, "modifier": "EXACT"}, "end": {"value": 425, "modifier": "EXACT"}}, "description": "", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}]}, {"type": "Compositional bias", "location": {"start": {"value": 232, "modifier": "EXACT"}, "end": {"value": 253, "modifier": "EXACT"}}, "description": "Low complexity", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 261, "modifier": "EXACT"}, "end": {"value": 274, "modifier": "EXACT"}}, "description": "Polar residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}, {"type": "Compositional bias", "location": {"start": {"value": 297, "modifier": "EXACT"}, "end": {"value": 314, "modifier": "EXACT"}}, "description": "Basic residues", "evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "MobiDB-lite"}]}], "keywords": [{"evidences": [{"evidenceCode": "ECO:0000256", "source": "SAM", "id": "Coils"}], "id": "KW-0175", "category": "Domain", "name": "Coiled coil"}, {"evidences": [{"evidenceCode": "ECO:0000256", "source": "ARBA", "id": "ARBA00023125"}], "id": "KW-0238", "category": "Molecular function", "name": "DNA-binding"}], "references": [{"referenceNumber": 1, "citation": {"id": "38132334", "citationType": "journal article", "authors": ["Kostyuchenko R.P.", "Nikanorova D.D.", "Amosov A.V."], "citationCrossReferences": [{"database": "PubMed", "id": "38132334"}], "title": "Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.", "publicationDate": "2023", "journal": "Biology", "firstPage": "0", "lastPage": "0", "volume": "12"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67475.1"}]}, {"referenceNumber": 2, "citation": {"id": "CI-DGQU0EDSTFBHR", "citationType": "submission", "authors": ["Kostyuchenko R.P."], "publicationDate": "OCT-2023", "submissionDatabase": "EMBL/GenBank/DDBJ databases"}, "referencePositions": ["NUCLEOTIDE SEQUENCE"], "evidences": [{"evidenceCode": "ECO:0000313", "source": "EMBL", "id": "XBW67475.1"}]}], "uniProtKBCrossReferences": [{"database": "EMBL", "id": "OR750680", "properties": [{"key": "ProteinId", "value": "XBW67475.1"}, {"key": "Status", "value": "-"}, {"key": "MoleculeType", "value": "mRNA"}]}, {"database": "GO", "id": "GO:0003677", "properties": [{"key": "GoTerm", "value": "F:DNA binding"}, {"key": "GoEvidenceType", "value": "IEA:UniProtKB-KW"}]}, {"database": "GO", "id": "GO:0003700", "properties": [{"key": "GoTerm", "value": "F:DNA-binding transcription factor activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "GO", "id": "GO:0046983", "properties": [{"key": "GoTerm", "value": "F:protein dimerization activity"}, {"key": "GoEvidenceType", "value": "IEA:InterPro"}]}, {"database": "CDD", "id": "cd11400", "properties": [{"key": "EntryName", "value": "bHLHzip_Myc"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "FunFam", "id": "4.10.280.10:FF:000019", "properties": [{"key": "EntryName", "value": "Myc proto-oncogene protein"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Gene3D", "id": "4.10.280.10", "properties": [{"key": "EntryName", "value": "Helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "InterPro", "id": "IPR011598", "properties": [{"key": "EntryName", "value": "bHLH_dom"}]}, {"database": "InterPro", "id": "IPR036638", "properties": [{"key": "EntryName", "value": "HLH_DNA-bd_sf"}]}, {"database": "InterPro", "id": "IPR050433", "properties": [{"key": "EntryName", "value": "Myc_transcription_factors"}]}, {"database": "InterPro", "id": "IPR002418", "properties": [{"key": "EntryName", "value": "Tscrpt_reg_Myc"}]}, {"database": "PANTHER", "id": "PTHR45851", "properties": [{"key": "EntryName", "value": "MYC PROTO-ONCOGENE"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "Pfam", "id": "PF00010", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PRINTS", "id": "PR00044", "properties": [{"key": "EntryName", "value": "LEUZIPPRMYC"}]}, {"database": "SMART", "id": "SM00353", "properties": [{"key": "EntryName", "value": "HLH"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "SUPFAM", "id": "SSF47459", "properties": [{"key": "EntryName", "value": "HLH, helix-loop-helix DNA-binding domain"}, {"key": "MatchStatus", "value": "1"}]}, {"database": "PROSITE", "id": "PS50888", "properties": [{"key": "EntryName", "value": "BHLH"}, {"key": "MatchStatus", "value": "1"}]}], "sequence": {"value": "MDLMNLPLNWLEDGLSEDPSQTMITDTSESYSQEFGPTPPHTPEYEQDSLDLLGDYPNDFMEEHFEQFEPQCRCQQPIVRDCMWSVNIPKTIHRSSSGQDSARFCGELSIPVLDSCSDCAGLESTPLCVDARTIFNLPCISKSPVKKQFHHNISSEDIIEERVCFIKSEAMEEYGSICISDDDYEVDVECLSDSSPDDLPYLPAHVPLSHSAVSAQIAEMHNYSQLSPPPSVSSARSCSRPSTTSYTRPSATSQFKHRTSSCRTTSSAPQSPSVPSLPAQFRPKHGTFSNPASPVVHARKHKNNNTSRNAKKRKLEQQRHRDHIGLMTPPGSDSDCEINRRAQHNVLERKRRNNLKEYFNHLRDQVPLLRSDVRTSKVVILQGAKNHISNMIESEKQVLAEKQRMIRQQQELKQRLQALRNAKARQGYL", "length": 429, "molWeight": 48562, "crc64": "EDBBE4EB20E603A2", "md5": "FC8FA1F809F07F5ECAB211943A1D9B25"}, "extraAttributes": {"countByFeatureType": {"Domain": 1, "Region": 1, "Coiled coil": 1, "Compositional bias": 3}, "uniParcId": "UPI0035D397FB"}, "cluster_size": 1, "family": "Enchytraeidae"}