--- pretty_name: "OpenH-RF — ULMShare (in vivo mouse transcranial ULM)" license: cc-by-4.0 task_categories: - image-to-image tags: - ultrasound - iq - openh-rf - ulm - super-resolution - microbubbles - in-vivo - mouse - brain language: - en size_categories: - 10K, Eindhoven University of Technology. ## Dataset Creation Date 08/21/2026 (zea conversion). The underlying acquisitions were recorded between March 2022 and March 2025. ## License / Terms of Use CC BY 4.0. See [LICENSE](./LICENSE). ## Intended Usage Ultrasound localization microscopy: microbubble detection and localization, frame-to-frame tracking, super-resolved vascular density and velocity mapping, and clutter filtering / tissue suppression. ## Dataset Characterization - **Data Collection Method:** in vivo animal (mouse), contrast-enhanced. - **Labeling Method:** none. A reference ULM density map rendered by the original authors is stored alongside the acquisitions as a `density_map` custom element — a visualization, not a ground-truth label. - **Acquisition system:** Verasonics Vantage 256. See files for further acquisition details. ## Dataset Format zea (HDF5), current release `zea_version` 0.1.4. Each acquisition is **one HDF5 file with a single track**. ``` / ├── probe/ name, type, probe_geometry, probe_center_frequency ├── metadata/ │ ├── credit DOI of the ULMShare publication │ ├── subject/ id, type, sex, genetic_strain, weight │ └── text_report procedure notes (where recorded) ├── custom/ acquisition context (see table below) └── tracks/track_0/ ├── data/raw_data (n_frames, n_tx, n_ax, n_el, 2) int16 ├── scan/ sampling_frequency, center_frequency, │ demodulation_frequency, sound_speed, │ initial_times, t0_delays, polar_angles, │ azimuth_angles, focus_distances, │ transmit_origins, tx_apodizations, │ tgc_gain_curve └── transmit_only False ``` **Large acquisitions split for upload:** The HuggingFace file-size limit is 500 GB. Four acquisitions are near or above it, so each one is split into two parts. These are `mouse_58/acquisition_1` (616 GB) and `mouse_59/acquisition_1` to `acquisition_3` (499 GB each). The split is at frame 240,000, into `_part1of2.hdf5` and `_part2of2.hdf5`. Both parts hold the same metadata: probe geometry, subject information, and clinical fields. To rebuild an acquisition, join `raw_data` from the two parts along axis 0. ### Per-sample feature table | Feature | Shape | Dtype | Units | Description | |---|---|---|---|---| | `data/raw_data` | `(n_frames, n_tx, n_ax, n_el, 2)` | `int16` | ADC counts | Baseband IQ channel data, `[I, Q]` (`I + jQ`) | | `probe/probe_geometry` | `(n_el, 3)` | `float32` | m | Element positions `(x, y, z)` | | `probe/probe_center_frequency` | `()` | `float32` | Hz | Probe center frequency | | `scan/sampling_frequency` | `()` | `float32` | Hz | IQ sampling rate (`fc` for BS100BW, `fc/2` for BS50BW) | | `scan/center_frequency`, `scan/demodulation_frequency` | `()` | `float32` | Hz | Transmit carrier / demodulation frequency | | `scan/sound_speed` | `()` | `float32` | m/s | 1540 | | `scan/polar_angles` | `(n_tx,)` | `float32` | rad | Plane-wave steering angles, ping-pong order | | `scan/azimuth_angles` | `(n_tx,)` | `float32` | rad | Zero (2D imaging) | | `scan/focus_distances` | `(n_tx,)` | `float32` | m | `inf` (unfocused plane waves) | | `scan/t0_delays` | `(n_tx, n_el)` | `float32` | s | Transmit delays, min 0 | | `scan/initial_times` | `(n_tx,)` | `float32` | s | Zero (MUST adds no per-transmit offset) | | `scan/tx_apodizations` | `(n_tx, n_el)` | `float32` | – | Ones (full aperture; see Known Issues) | | `scan/transmit_origins` | `(n_tx, 3)` | `float32` | m | Zero | | `scan/tgc_gain_curve` | `(n_ax,)` | `float32` | – | 8 source control points interpolated per sample | | `metadata/subject/weight` | `()` | `float32` | kg | Mouse body weight | | `custom/density_map` | `(H, W, 3)` or `(H, W)` | `uint8` | – | Reference ULM density map PNG | ### Custom elements Acquisition context with no zea spec field, stored as strings exactly as recorded upstream: `anesthesia`, `injection_type`, `mb_dilution`, `volume_mb_injected`, `frame_rate_hz`, `npulse`, `voltage`, `mouse_weight`, `mouse_age_days`, `mouse_animal_protocol_id`, `flush`, and (where non-blank) `procedure_type`, `slice_position`, `temperature`, `syringe_gauge`. ## Dataset Quantification **Current OpenH-RF release:** 103 HDF5 files; 20.74 TB (20,735,658,275,478 bytes) stored; root `zea_version` **0.1.4**. Sizes include all HDF5 contents and use decimal units (MB = 10^6 bytes, GB = 10^9 bytes, TB = 10^12 bytes), not decoded-array memory or original-source download sizes. - **Acquisitions:** 99, from 61 mice — one zea HDF5 file per acquisition. - **Stored HDF5 size:** 20.74 TB (20,735,658,275,478 bytes). - **Split:** none. ## Subject Metadata Aggregate only; the subjects are mice, so no PHI applies. Subject attributes are counted per mouse (n = 61); probe and imaging plane per acquisition (n = 99). - **Subjects:** 61 mice, 99 acquisitions. - **Sex:** 36 female, 22 male, 3 unrecorded. - **Strain:** C57BL/6J (48), C57BL/6N (13). - **Age:** 22–216 days (recorded for 56 of 61). - **Weight:** 11.3–31.0 g (recorded for 55 of 61). - **Anatomy:** whole-brain transcranial, through the intact skull. An imaging plane is named for 23 of 99 acquisitions: striatum, hippocampus, midbrain, pons, cerebellum. - **Pathology:** none — all animals are healthy. - **Probe model:** L22-14v (77), GEL818iD (15), L22-14vX (7). - **Sites:** McGill University (43 mice), ICM / Paris Brain Institute (12), Université de Montréal (6). ## Data Validation - Standard B-mode and B-mode with tissue suppression `zea` pipelines available in `pipeline_bmode.yaml` and `pipeline_tissue_suppression.yaml`, respectively. ## Known Issues - N/A ## Ethical Considerations - **Data tier:** in vivo animal (mouse). No human subjects, no protected health information, and no participant-consent or IRB requirement applies. - **Animal use approval:** acquisitions were performed under an institutional animal use protocol. `custom/mouse_animal_protocol_id` records the identifier per acquisition. Recording sites are McGill University, the ICM (Institut de cardiologie de Montréal), and Université de Montréal. The approval statements themselves belong to the original ULMShare authors and should be reproduced from their publication when this conversion is published, rather than inferred from the protocol identifiers alone. - **Animal welfare (ARRIVE 2.0):** the essential-10 reporting items that this dataset can carry are recorded per acquisition and summarized under Subject Metadata — species and strain, sex, age, weight, health status (all healthy; no disease model), anesthetic protocol, contrast-agent route and dose, and recording site. Items that belong to the original study design rather than the released data — sample-size rationale, randomization, blinding, and outcome definitions — are not reproduced here and should be taken from the ULMShare publication. - **De-identification:** not applicable to animal subjects. Subject IDs are coded (`mouse_18`), and no date of birth is carried into the zea files — only age in days. - **Procedures:** no terminal procedure is represented; imaging is transcranial through the intact skull. ## Citation CC BY 4.0 requires attribution to the original authors. Cite the **dataset**: Rauby, B., Ghigo, N., Ramos-Palacios, G., Leconte, A., Lee, S., Wu, A., Xing, P., Gulenko, O., Caron, L., Malescot, A., Martineau, É., Porée, J., Gasse, M., Rungta, R., Sadikot, A., Provost, J. (2026). *ULMShare: A Large-Scale In Vivo Ultrasound Localization Microscopy Dataset for Microvascular Imaging.* Federated Research Data Repository. [doi:10.20383/103.01550](https://doi.org/10.20383/103.01550) and, where the methods are relevant, the accompanying preprint: [arXiv:2606.07851](https://doi.org/10.48550/arXiv.2606.07851). Note that `metadata/credit` inside the converted files carries the source `acquisition.json`'s `doi_citations` where those are recorded, and otherwise falls back to the preprint DOI above; the FRDR dataset DOI is the canonical citation target for the data itself.