Question:
During review of a kidney case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target lung case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What is the overall degree of histologic differentiation in this tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
For a target colorectum case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which nodal involvement category is supported by the examined sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
For a target endometrium case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which grade under the FIGO histologic grading system should be recorded for this tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a soft tissue specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a thyroid specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a stomach specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a lung specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a stomach case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What final margin status should be assigned for invasive tumor?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What is the overall degree of histologic differentiation in this tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
During review of a stomach case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Based on the submitted material, what is the greatest regional nodal tumor burden that can be assessed?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target stomach case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What final grade under the Nottingham histologic grading system should be assigned to this tumor?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a stomach specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What level of nodal metastatic burden is supported by the submitted H&E material?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The target case is a endometrium specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What margin status is supported for invasive tumor in the submitted specimen?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What is the most appropriate final histologic diagnosis for this kidney tumor?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What final local-invasion category should be assigned to this renal tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
For a target thyroid case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which histologic diagnosis is supported by the submitted H&E material from this breast tumor?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a colorectum specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a thyroid specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a thyroid specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which differentiation category best matches the viable tumor?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a urinary bladder specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
For a target lung case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a colorectum specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What is the most adverse invasive-tumor margin status in the submitted specimen?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a breast specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a stomach case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Based on the submitted material, what is the greatest regional nodal tumor burden that can be assessed?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a lung specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What is the largest metastatic deposit category, if any, supported by the submitted material?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
For a target endometrium case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which grade category under the FIGO histologic grading system best matches this tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target kidney case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target thyroid case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a urinary bladder specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which diagnosis best accounts for the dominant morphology of this urinary bladder tumor?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target lung case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

How differentiated is this tumor on H&E?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a stomach case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What final margin status should be assigned for invasive tumor?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a endometrium case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

How should the closest relevant margin be reported in relation to invasive tumor?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What histologic diagnosis should be recorded for this kidney tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
For a target kidney case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which diagnosis is most consistent with the submitted H&E morphology of this kidney neoplasm?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

How should invasive-tumor margin status be recorded?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target kidney case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which grade under the Fuhrman nuclear grading system belongs in the final pathology assessment?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a endometrium specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a urinary bladder specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a colorectum specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which nodal tumor-burden category should be entered for this case?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a stomach case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Based on the submitted material, what is the greatest regional nodal tumor burden that can be assessed?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a endometrium case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which anatomic level of invasion is reached by this endometrial tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
For a target lung case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
For a target lung case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

What differentiation assessment is supported by the tumor morphology?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target lung case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which histologic diagnosis is supported by the submitted H&E material from this breast tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which diagnosis is most consistent with the submitted H&E morphology of this breast neoplasm?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a breast specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What margin assessment is supported for invasive tumor in this specimen?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which finding best summarizes involvement of the regional lymph nodes?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a kidney case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a stomach specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What final margin category should be entered for invasive tumor?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
During review of a urinary bladder case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What level of nodal metastatic burden is supported by the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a soft tissue specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
For a target breast case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

What histologic diagnosis should be recorded for this breast tumor?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a thyroid case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
For a target kidney case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a urinary bladder specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a esophagus specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which diagnosis best represents the morphology of this kidney tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a thyroid specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

How should the maximum regional nodal tumor-burden category be documented?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a breast specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a colorectum specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which level of local invasion is supported by the submitted sections of this colorectal tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target lung case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

What final margin status should be assigned for invasive tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target lung case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Based on the submitted material, what is the greatest regional nodal tumor burden that can be assessed?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What is the greatest anatomic extent of invasion by this renal tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
During review of a colorectum case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What is the greatest anatomic extent of invasion by this colorectal tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What is the largest metastatic deposit category, if any, supported by the submitted material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target stomach case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which category best summarizes tumor involvement of the regional lymph nodes?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
For a target lung case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a kidney case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
For a target kidney case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which finding best summarizes involvement of the regional lymph nodes?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a lung specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a lung specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a breast specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which diagnosis best accounts for the dominant morphology of this breast tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which description best matches the greatest anatomic extent of invasion by this renal tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a lung specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

How should the maximum regional nodal tumor-burden category be documented?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a thyroid case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target stomach case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which nodal involvement category is supported by the examined sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a urinary bladder specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a colorectum specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
For a target endometrium case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target urinary bladder case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a colorectum specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What deepest anatomic extent should be documented for this colorectal tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
For a target endometrium case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a urinary bladder case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a thyroid specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a endometrium case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What grade under the FIGO histologic grading system should be entered in the pathology report?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target breast case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target endometrium case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which description best reflects the status of the submitted resection margins for invasive tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
For a target breast case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What is the most adverse invasive-tumor margin status in the submitted specimen?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a colorectum specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which diagnosis best represents the morphology of this colorectal tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

How should invasive-tumor margin status be recorded?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which diagnosis should appear in the final pathology assessment of this breast tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a thyroid specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a stomach specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which description best matches the greatest anatomic extent of invasion by this renal tumor?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a lung specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
For a target breast case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a lung specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a endometrium case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What is the deepest local extension of this endometrial tumor?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
For a target colorectum case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which nodal involvement category is supported by the examined sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The target case is a breast specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a colorectum specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which combination of perineural and lymphovascular invasion is identified in the submitted tumor sections?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
For a target breast case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which diagnosis should appear in the final pathology assessment of this breast tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Based on the submitted material, what is the greatest regional nodal tumor burden that can be assessed?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which nodal tumor-burden category should be entered for this case?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a stomach specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The target case is a breast specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What should be communicated about the closest relevant margin for invasive tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
The diagnostic workup concerns a endometrium specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which nodal involvement category is supported by the examined sections?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a colorectum specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a lung specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
During review of a endometrium case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What is the deepest local extension of this endometrial tumor?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

How should local extension of this renal tumor be categorized morphologically?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
During review of a kidney case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which histologic diagnosis is supported by the submitted H&E material from this kidney tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What level of nodal metastatic burden is supported by the submitted H&E material?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
During review of a thyroid case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What final nodal tumor-burden category should be assigned?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a endometrium specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. None of the candidate WSI sets contains target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue