Question:
For a target stomach case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

Which finding best summarizes involvement of the regional lymph nodes?

Choices:
A. Candidate WSI Set 2 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a breast specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target colorectum case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
During review of a breast case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What should be communicated about the closest relevant margin for invasive tumor?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
For a target endometrium case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

Which focal invasion pattern is supported by review of the submitted H&E material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a lung case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

After microscopic review of all submitted H&E slides, which focal route-of-spread pattern is present?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The target case is a kidney specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What final local-invasion category should be assigned to this renal tumor?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. None of the candidate WSI sets contains target-relevant H&E tissue
D. Candidate WSI Set 2 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
For a target kidney case, three candidate H&E WSI sets are provided. Which set contains the relevant tissue needed for the following diagnostic question, or do none of them?

What is the most adverse invasive-tumor margin status in the submitted specimen?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

None of the candidate WSI sets contains target-relevant H&E tissue


Question:
During review of a endometrium case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

Which category best summarizes tumor involvement of the regional lymph nodes?

Choices:
A. Candidate WSI Set 1 contains the target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 2 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a colorectum specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What is the deepest local extension of this colorectal tumor?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The target case is a breast specimen. Review Candidate WSI Sets 1-3 for the diagnostic question below. Which set contains target-relevant H&E tissue sufficient to address it, or is that evidence absent?

What is the largest metastatic deposit category, if any, supported by the submitted material?

Choices:
A. Candidate WSI Set 3 contains the target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 1 contains the target-relevant H&E tissue
D. None of the candidate WSI sets contains target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a kidney specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

What final margin category should be entered for invasive tumor?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 3 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 3 contains the target-relevant H&E tissue


Question:
During review of a endometrium case, compare the three submitted H&E WSI sets. Which set can support an answer to the target question, or is the target tissue absent from all three?

What combination of microscopic perineural and lymphovascular spread should be recorded for this case?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 2 contains the target-relevant H&E tissue
C. Candidate WSI Set 3 contains the target-relevant H&E tissue
D. Candidate WSI Set 1 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue


Question:
The diagnostic workup concerns a thyroid specimen. After reviewing Candidate WSI Sets 1-3, identify the set with appropriate target H&E tissue for the question below, or indicate that none is suitable.

Which description best reflects the status of the submitted resection margins for invasive tumor?

Choices:
A. None of the candidate WSI sets contains target-relevant H&E tissue
B. Candidate WSI Set 1 contains the target-relevant H&E tissue
C. Candidate WSI Set 2 contains the target-relevant H&E tissue
D. Candidate WSI Set 3 contains the target-relevant H&E tissue

Candidate WSI Set 1 contains the target-relevant H&E tissue