File size: 19,575 Bytes
e4b9a7b
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
# Copyright 2020 MONAI Consortium
# Licensed under the Apache License, Version 2.0 (the "License");
# you may not use this file except in compliance with the License.
# You may obtain a copy of the License at
#     http://www.apache.org/licenses/LICENSE-2.0
# Unless required by applicable law or agreed to in writing, software
# distributed under the License is distributed on an "AS IS" BASIS,
# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# See the License for the specific language governing permissions and
# limitations under the License.

import random
import warnings
from typing import Callable, List, Optional, Sequence, Tuple, Union

import numpy as np
import torch

from monai.config import IndexSelection
from monai.utils import ensure_tuple, ensure_tuple_size, fall_back_tuple, min_version, optional_import

measure, _ = optional_import("skimage.measure", "0.14.2", min_version)


def rand_choice(prob: float = 0.5) -> bool:
    """
    Returns True if a randomly chosen number is less than or equal to `prob`, by default this is a 50/50 chance.
    """
    return bool(random.random() <= prob)


def img_bounds(img: np.ndarray) -> np.ndarray:
    """
    Returns the minimum and maximum indices of non-zero lines in axis 0 of `img`, followed by that for axis 1.
    """
    ax0 = np.any(img, axis=0)
    ax1 = np.any(img, axis=1)
    return np.concatenate((np.where(ax0)[0][[0, -1]], np.where(ax1)[0][[0, -1]]))


def in_bounds(x: float, y: float, margin: float, maxx: float, maxy: float) -> bool:
    """
    Returns True if (x,y) is within the rectangle (margin, margin, maxx-margin, maxy-margin).
    """
    return bool(margin <= x < (maxx - margin) and margin <= y < (maxy - margin))


def is_empty(img: Union[np.ndarray, torch.Tensor]) -> bool:
    """
    Returns True if `img` is empty, that is its maximum value is not greater than its minimum.
    """
    return not (img.max() > img.min())  # use > instead of <= so that an image full of NaNs will result in True


def zero_margins(img: np.ndarray, margin: int) -> bool:
    """
    Returns True if the values within `margin` indices of the edges of `img` in dimensions 1 and 2 are 0.
    """
    if np.any(img[:, :, :margin]) or np.any(img[:, :, -margin:]):
        return False

    if np.any(img[:, :margin, :]) or np.any(img[:, -margin:, :]):
        return False

    return True


def rescale_array(
    arr: np.ndarray, minv: float = 0.0, maxv: float = 1.0, dtype: Optional[np.dtype] = np.float32
) -> np.ndarray:
    """
    Rescale the values of numpy array `arr` to be from `minv` to `maxv`.
    """
    if dtype is not None:
        arr = arr.astype(dtype)

    mina = np.min(arr)
    maxa = np.max(arr)

    if mina == maxa:
        return arr * minv

    norm = (arr - mina) / (maxa - mina)  # normalize the array first
    return (norm * (maxv - minv)) + minv  # rescale by minv and maxv, which is the normalized array by default


def rescale_instance_array(
    arr: np.ndarray, minv: float = 0.0, maxv: float = 1.0, dtype: np.dtype = np.float32
) -> np.ndarray:
    """
    Rescale each array slice along the first dimension of `arr` independently.
    """
    out: np.ndarray = np.zeros(arr.shape, dtype)
    for i in range(arr.shape[0]):
        out[i] = rescale_array(arr[i], minv, maxv, dtype)

    return out


def rescale_array_int_max(arr: np.ndarray, dtype: np.dtype = np.uint16) -> np.ndarray:
    """
    Rescale the array `arr` to be between the minimum and maximum values of the type `dtype`.
    """
    info: np.iinfo = np.iinfo(dtype)
    return rescale_array(arr, info.min, info.max).astype(dtype)


def copypaste_arrays(
    src: np.ndarray,
    dest: np.ndarray,
    srccenter: Sequence[int],
    destcenter: Sequence[int],
    dims: Sequence[Optional[int]],
) -> Tuple[Tuple[slice, ...], Tuple[slice, ...]]:
    """
    Calculate the slices to copy a sliced area of array `src` into array `dest`. The area has dimensions `dims` (use 0
    or None to copy everything in that dimension), the source area is centered at `srccenter` index in `src` and copied
    into area centered at `destcenter` in `dest`. The dimensions of the copied area will be clipped to fit within the
    source and destination arrays so a smaller area may be copied than expected. Return value is the tuples of slice
    objects indexing the copied area in `src`, and those indexing the copy area in `dest`.

    Example

    .. code-block:: python

        src = np.random.randint(0,10,(6,6))
        dest = np.zeros_like(src)
        srcslices, destslices = copypaste_arrays(src, dest, (3, 2),(2, 1),(3, 4))
        dest[destslices] = src[srcslices]
        print(src)
        print(dest)

        >>> [[9 5 6 6 9 6]
             [4 3 5 6 1 2]
             [0 7 3 2 4 1]
             [3 0 0 1 5 1]
             [9 4 7 1 8 2]
             [6 6 5 8 6 7]]
            [[0 0 0 0 0 0]
             [7 3 2 4 0 0]
             [0 0 1 5 0 0]
             [4 7 1 8 0 0]
             [0 0 0 0 0 0]
             [0 0 0 0 0 0]]

    """
    srcslices = [slice(None)] * src.ndim
    destslices = [slice(None)] * dest.ndim

    for i, ss, ds, sc, dc, dim in zip(range(src.ndim), src.shape, dest.shape, srccenter, destcenter, dims):
        if dim:
            # dimension before midpoint, clip to size fitting in both arrays
            d1 = np.clip(dim // 2, 0, min(sc, dc))
            # dimension after midpoint, clip to size fitting in both arrays
            d2 = np.clip(dim // 2 + 1, 0, min(ss - sc, ds - dc))

            srcslices[i] = slice(sc - d1, sc + d2)
            destslices[i] = slice(dc - d1, dc + d2)

    return tuple(srcslices), tuple(destslices)


def resize_center(img: np.ndarray, *resize_dims: Optional[int], fill_value: float = 0.0) -> np.ndarray:
    """
    Resize `img` by cropping or expanding the image from the center. The `resize_dims` values are the output dimensions
    (or None to use original dimension of `img`). If a dimension is smaller than that of `img` then the result will be
    cropped and if larger padded with zeros, in both cases this is done relative to the center of `img`. The result is
    a new image with the specified dimensions and values from `img` copied into its center.
    """
    resize_dims = tuple(resize_dims[i] or img.shape[i] for i in range(len(resize_dims)))

    dest = np.full(resize_dims, fill_value, img.dtype)
    half_img_shape = np.asarray(img.shape) // 2
    half_dest_shape = np.asarray(dest.shape) // 2

    srcslices, destslices = copypaste_arrays(img, dest, half_img_shape, half_dest_shape, resize_dims)
    dest[destslices] = img[srcslices]

    return dest


def map_binary_to_indices(
    label: np.ndarray,
    image: Optional[np.ndarray] = None,
    image_threshold: float = 0.0,
) -> Tuple[np.ndarray, np.ndarray]:
    """
    Compute the foreground and background of input label data, return the indices after fattening.
    For example:
    ``label = np.array([[[0, 1, 1], [1, 0, 1], [1, 1, 0]]])``
    ``foreground indices = np.array([1, 2, 3, 5, 6, 7])`` and ``background indices = np.array([0, 4, 8])``

    Args:
        label: use the label data to get the foreground/background information.
        image: if image is not None, use ``label = 0 & image > image_threshold``
            to define background. so the output items will not map to all the voxels in the label.
        image_threshold: if enabled `image`, use ``image > image_threshold`` to
            determine the valid image content area and select background only in this area.

    """
    # Prepare fg/bg indices
    if label.shape[0] > 1:
        label = label[1:]  # for One-Hot format data, remove the background channel
    label_flat = np.any(label, axis=0).ravel()  # in case label has multiple dimensions
    fg_indices = np.nonzero(label_flat)[0]
    if image is not None:
        img_flat = np.any(image > image_threshold, axis=0).ravel()
        bg_indices = np.nonzero(np.logical_and(img_flat, ~label_flat))[0]
    else:
        bg_indices = np.nonzero(~label_flat)[0]
    return fg_indices, bg_indices


def generate_pos_neg_label_crop_centers(
    spatial_size: Union[Sequence[int], int],
    num_samples: int,
    pos_ratio: float,
    label_spatial_shape: Sequence[int],
    fg_indices: np.ndarray,
    bg_indices: np.ndarray,
    rand_state: np.random.RandomState = np.random,
) -> List[List[np.ndarray]]:
    """
    Generate valid sample locations based on the label with option for specifying foreground ratio
    Valid: samples sitting entirely within image, expected input shape: [C, H, W, D] or [C, H, W]

    Args:
        spatial_size: spatial size of the ROIs to be sampled.
        num_samples: total sample centers to be generated.
        pos_ratio: ratio of total locations generated that have center being foreground.
        label_spatial_shape: spatial shape of the original label data to unravel selected centers.
        fg_indices: pre-computed foreground indices in 1 dimension.
        bg_indices: pre-computed background indices in 1 dimension.
        rand_state: numpy randomState object to align with other modules.

    Raises:
        ValueError: When the proposed roi is larger than the image.
        ValueError: When the foreground and background indices lengths are 0.

    """
    spatial_size = fall_back_tuple(spatial_size, default=label_spatial_shape)
    if not (np.subtract(label_spatial_shape, spatial_size) >= 0).all():
        raise ValueError("The proposed roi is larger than the image.")

    # Select subregion to assure valid roi
    valid_start = np.floor_divide(spatial_size, 2)
    # add 1 for random
    valid_end = np.subtract(label_spatial_shape + np.array(1), spatial_size / np.array(2)).astype(np.uint16)
    # int generation to have full range on upper side, but subtract unfloored size/2 to prevent rounded range
    # from being too high
    for i in range(len(valid_start)):  # need this because np.random.randint does not work with same start and end
        if valid_start[i] == valid_end[i]:
            valid_end[i] += 1

    def _correct_centers(
        center_ori: List[np.ndarray], valid_start: np.ndarray, valid_end: np.ndarray
    ) -> List[np.ndarray]:
        for i, c in enumerate(center_ori):
            center_i = c
            if c < valid_start[i]:
                center_i = valid_start[i]
            if c >= valid_end[i]:
                center_i = valid_end[i] - 1
            center_ori[i] = center_i
        return center_ori

    centers = []

    if not len(fg_indices) or not len(bg_indices):
        if not len(fg_indices) and not len(bg_indices):
            raise ValueError("No sampling location available.")
        warnings.warn(
            f"N foreground {len(fg_indices)}, N  background {len(bg_indices)},"
            "unable to generate class balanced samples."
        )
        pos_ratio = 0 if not len(fg_indices) else 1

    for _ in range(num_samples):
        indices_to_use = fg_indices if rand_state.rand() < pos_ratio else bg_indices
        random_int = rand_state.randint(len(indices_to_use))
        center = np.unravel_index(indices_to_use[random_int], label_spatial_shape)
        # shift center to range of valid centers
        center_ori = list(center)
        centers.append(_correct_centers(center_ori, valid_start, valid_end))

    return centers


def apply_transform(transform: Callable, data, map_items: bool = True):
    """
    Transform `data` with `transform`.
    If `data` is a list or tuple and `map_data` is True, each item of `data` will be transformed
    and this method returns a list of outcomes.
    otherwise transform will be applied once with `data` as the argument.

    Args:
        transform: a callable to be used to transform `data`
        data: an object to be transformed.
        map_items: whether to apply transform to each item in `data`,
            if `data` is a list or tuple. Defaults to True.

    Raises:
        Exception: When ``transform`` raises an exception.

    """
    try:
        if isinstance(data, (list, tuple)) and map_items:
            return [transform(item) for item in data]
        return transform(data)
    except Exception as e:
        raise type(e)(f"Applying transform {transform}.").with_traceback(e.__traceback__)


def create_grid(
    spatial_size: Sequence[int],
    spacing: Optional[Sequence[float]] = None,
    homogeneous: bool = True,
    dtype: np.dtype = float,
) -> np.ndarray:
    """
    compute a `spatial_size` mesh.

    Args:
        spatial_size: spatial size of the grid.
        spacing: same len as ``spatial_size``, defaults to 1.0 (dense grid).
        homogeneous: whether to make homogeneous coordinates.
        dtype: output grid data type.
    """
    spacing = spacing or tuple(1.0 for _ in spatial_size)
    ranges = [np.linspace(-(d - 1.0) / 2.0 * s, (d - 1.0) / 2.0 * s, int(d)) for d, s in zip(spatial_size, spacing)]
    coords = np.asarray(np.meshgrid(*ranges, indexing="ij"), dtype=dtype)
    if not homogeneous:
        return coords
    return np.concatenate([coords, np.ones_like(coords[:1])])


def create_control_grid(
    spatial_shape: Sequence[int], spacing: Sequence[float], homogeneous: bool = True, dtype: np.dtype = float
) -> np.ndarray:
    """
    control grid with two additional point in each direction
    """
    grid_shape = []
    for d, s in zip(spatial_shape, spacing):
        d = int(d)
        if d % 2 == 0:
            grid_shape.append(np.ceil((d - 1.0) / (2.0 * s) + 0.5) * 2.0 + 2.0)
        else:
            grid_shape.append(np.ceil((d - 1.0) / (2.0 * s)) * 2.0 + 3.0)
    return create_grid(grid_shape, spacing, homogeneous, dtype)


def create_rotate(spatial_dims: int, radians: Union[Sequence[float], float]) -> np.ndarray:
    """
    create a 2D or 3D rotation matrix

    Args:
        spatial_dims: {``2``, ``3``} spatial rank
        radians: rotation radians
            when spatial_dims == 3, the `radians` sequence corresponds to
            rotation in the 1st, 2nd, and 3rd dim respectively.

    Raises:
        ValueError: When ``radians`` is empty.
        ValueError: When ``spatial_dims`` is not one of [2, 3].

    """
    radians = ensure_tuple(radians)
    if spatial_dims == 2:
        if len(radians) >= 1:
            sin_, cos_ = np.sin(radians[0]), np.cos(radians[0])
            return np.array([[cos_, -sin_, 0.0], [sin_, cos_, 0.0], [0.0, 0.0, 1.0]])
        raise ValueError("radians must be non empty.")

    if spatial_dims == 3:
        affine = None
        if len(radians) >= 1:
            sin_, cos_ = np.sin(radians[0]), np.cos(radians[0])
            affine = np.array(
                [[1.0, 0.0, 0.0, 0.0], [0.0, cos_, -sin_, 0.0], [0.0, sin_, cos_, 0.0], [0.0, 0.0, 0.0, 1.0]]
            )
        if len(radians) >= 2:
            sin_, cos_ = np.sin(radians[1]), np.cos(radians[1])
            affine = affine @ np.array(
                [[cos_, 0.0, sin_, 0.0], [0.0, 1.0, 0.0, 0.0], [-sin_, 0.0, cos_, 0.0], [0.0, 0.0, 0.0, 1.0]]
            )
        if len(radians) >= 3:
            sin_, cos_ = np.sin(radians[2]), np.cos(radians[2])
            affine = affine @ np.array(
                [[cos_, -sin_, 0.0, 0.0], [sin_, cos_, 0.0, 0.0], [0.0, 0.0, 1.0, 0.0], [0.0, 0.0, 0.0, 1.0]]
            )
        if affine is None:
            raise ValueError("radians must be non empty.")
        return affine

    raise ValueError(f"Unsupported spatial_dims: {spatial_dims}, available options are [2, 3].")


def create_shear(spatial_dims: int, coefs: Union[Sequence[float], float]) -> np.ndarray:
    """
    create a shearing matrix

    Args:
        spatial_dims: spatial rank
        coefs: shearing factors, defaults to 0.

    Raises:
        NotImplementedError: When ``spatial_dims`` is not one of [2, 3].

    """
    if spatial_dims == 2:
        coefs = ensure_tuple_size(coefs, dim=2, pad_val=0.0)
        return np.array([[1, coefs[0], 0.0], [coefs[1], 1.0, 0.0], [0.0, 0.0, 1.0]])
    if spatial_dims == 3:
        coefs = ensure_tuple_size(coefs, dim=6, pad_val=0.0)
        return np.array(
            [
                [1.0, coefs[0], coefs[1], 0.0],
                [coefs[2], 1.0, coefs[3], 0.0],
                [coefs[4], coefs[5], 1.0, 0.0],
                [0.0, 0.0, 0.0, 1.0],
            ]
        )
    raise NotImplementedError("Currently only spatial_dims in [2, 3] are supported.")


def create_scale(spatial_dims: int, scaling_factor: Union[Sequence[float], float]) -> np.ndarray:
    """
    create a scaling matrix

    Args:
        spatial_dims: spatial rank
        scaling_factor: scaling factors, defaults to 1.
    """
    scaling_factor = ensure_tuple_size(scaling_factor, dim=spatial_dims, pad_val=1.0)
    return np.diag(scaling_factor[:spatial_dims] + (1.0,))


def create_translate(spatial_dims: int, shift: Union[Sequence[float], float]) -> np.ndarray:
    """
    create a translation matrix

    Args:
        spatial_dims: spatial rank
        shift: translate factors, defaults to 0.
    """
    shift = ensure_tuple(shift)
    affine = np.eye(spatial_dims + 1)
    for i, a in enumerate(shift[:spatial_dims]):
        affine[i, spatial_dims] = a
    return affine


def generate_spatial_bounding_box(
    img: np.ndarray,
    select_fn: Callable = lambda x: x > 0,
    channel_indices: Optional[IndexSelection] = None,
    margin: int = 0,
) -> Tuple[List[int], List[int]]:
    """
    generate the spatial bounding box of foreground in the image with start-end positions.
    Users can define arbitrary function to select expected foreground from the whole image or specified channels.
    And it can also add margin to every dim of the bounding box.

    Args:
        img: source image to generate bounding box from.
        select_fn: function to select expected foreground, default is to select values > 0.
        channel_indices: if defined, select foreground only on the specified channels
            of image. if None, select foreground on the whole image.
        margin: add margin to all dims of the bounding box.
    """
    assert isinstance(margin, int), "margin must be int type."
    data = img[[*(ensure_tuple(channel_indices))]] if channel_indices is not None else img
    data = np.any(select_fn(data), axis=0)
    nonzero_idx = np.nonzero(data)

    box_start = list()
    box_end = list()
    for i in range(data.ndim):
        assert len(nonzero_idx[i]) > 0, f"did not find nonzero index at spatial dim {i}"
        box_start.append(max(0, np.min(nonzero_idx[i]) - margin))
        box_end.append(min(data.shape[i], np.max(nonzero_idx[i]) + margin + 1))
    return box_start, box_end


def get_largest_connected_component_mask(img: torch.Tensor, connectivity: Optional[int] = None) -> torch.Tensor:
    """
    Gets the largest connected component mask of an image.

    Args:
        img: Image to get largest connected component from. Shape is (batch_size, spatial_dim1 [, spatial_dim2, ...])
        connectivity: Maximum number of orthogonal hops to consider a pixel/voxel as a neighbor.
            Accepted values are ranging from  1 to input.ndim. If ``None``, a full
            connectivity of ``input.ndim`` is used.
    """
    img_arr = img.detach().cpu().numpy()
    largest_cc = np.zeros(shape=img_arr.shape, dtype=img_arr.dtype)
    for i, item in enumerate(img_arr):
        item = measure.label(item, connectivity=connectivity)
        if item.max() != 0:
            largest_cc[i, ...] = item == (np.argmax(np.bincount(item.flat)[1:]) + 1)
    return torch.as_tensor(largest_cc, device=img.device)