{"query": {"id": "q_0", "content": "Naloxone [SEP] Naloxone reverses the antihypertensive effect of clonidine.", "tokenized_content": [2, 21926, 3, 21926, 28817, 1920, 16439, 2495, 1927, 26596, 18, 3]}, "items": [{"id": "p_0", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_1", "content": "clonidine [SEP] Naloxone reverses the antihypertensive effect of clonidine.", "tokenized_content": [2, 26596, 3, 21926, 28817, 1920, 16439, 2495, 1927, 26596, 18, 3]}, "items": [{"id": "p_1", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_2", "content": "hypertensive [SEP] In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by ", "tokenized_content": [2, 11706, 3, 1922, 26844, 11682, 20536, 1914, 6756, 16, 12753, 11706, 3615, 1920, 3714, 1922, 2877, 3772, 1930, 4003, 2769, 4152, 2007, 3]}, "items": [{"id": "p_2", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3", "content": "clonidine [SEP] crease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone, ", "tokenized_content": [2, 26596, 3, 3478, 2051, 1922, 2877, 3772, 1930, 4003, 2769, 4152, 2007, 7307, 26596, 16, 25, 1942, 2036, 13362, 19, 3621, 16, 1982, 5069, 2014, 9432, 2007, 13120, 12852, 2912, 3]}, "items": [{"id": "p_3", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_4", "content": "hypotensive [SEP] /kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reverse", "tokenized_content": [2, 12201, 3766, 3, 19, 3621, 16, 1982, 5069, 2014, 9432, 2007, 13120, 12852, 2912, 16, 20, 18, 22, 1942, 22, 2786, 19, 3621, 18, 1920, 12201, 3766, 2495, 1927, 2813, 3]}, "items": [{"id": "p_4", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_5", "content": "alpha-methyldopa [SEP] y nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone did not", "tokenized_content": [2, 4595, 17, 4963, 22389, 4302, 3, 67, 13120, 12852, 2912, 16, 20, 18, 22, 1942, 22, 2786, 19, 3621, 18, 1920, 12201, 3766, 2495, 1927, 2813, 2786, 19, 3621, 4595, 3]}, "items": [{"id": "p_5", "content": "Methyldopa [SEP] An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an ant", "score": 1, "type": null, "tokenized_content": [2, 4963, 22389, 4302, 3, 1925, 4595, 17, 22, 13672, 7829, 1988, 2258, 2321, 4101, 1930, 5009, 7580, 2433, 2564, 18, 2496, 3065, 2535, 2485, 1977, 1966, 1925, 4942, 3]}]}
{"query": {"id": "q_6", "content": "naloxone [SEP] ct of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone did not affect either blood pressure or heart r", "tokenized_content": [2, 21926, 3, 3369, 1927, 2813, 2786, 19, 3621, 4595, 17, 4963, 22389, 4302, 1982, 2222, 6426, 9432, 2007, 21926, 18, 21926, 4298, 2811, 2084, 4081, 3108, 2877, 3772, 2014, 4003, 3]}, "items": [{"id": "p_6", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_7", "content": "Naloxone [SEP] mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone did not affect either blood pressure or heart rate. In br", "tokenized_content": [2, 21926, 3, 2786, 19, 3621, 4595, 17, 4963, 22389, 4302, 1982, 2222, 6426, 9432, 2007, 21926, 18, 21926, 4298, 2811, 2084, 4081, 3108, 2877, 3772, 2014, 4003, 2769, 18, 1922, 3]}, "items": [{"id": "p_7", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_8", "content": "Lidocaine [SEP] Lidocaine-induced cardiac asystole.", "tokenized_content": [2, 19567, 3, 19567, 17, 2719, 4435, 1966, 2298, 2456, 18, 3]}, "items": [{"id": "p_8", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_9", "content": "cardiac asystole [SEP] Lidocaine-induced cardiac asystole.", "tokenized_content": [2, 4435, 1966, 2298, 2456, 3, 19567, 17, 2719, 4435, 1966, 2298, 2456, 18, 3]}, "items": [{"id": "p_9", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_10", "content": "lidocaine [SEP] Intravenous administration of a single 50-mg bolus of lidocaine in a 67-year-old man resulted in profound depression of the act", "tokenized_content": [2, 19567, 3, 7307, 4183, 1927, 43, 2957, 2761, 17, 2786, 14840, 1927, 19567, 1922, 43, 4838, 17, 2476, 17, 4156, 2323, 4306, 1922, 11098, 4621, 1927, 1920, 4033, 3]}, "items": [{"id": "p_10", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_11", "content": "depression [SEP] mg bolus of lidocaine in a 67-year-old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pa", "tokenized_content": [2, 4621, 3, 2786, 14840, 1927, 19567, 1922, 43, 4838, 17, 2476, 17, 4156, 2323, 4306, 1922, 11098, 4621, 1927, 1920, 2455, 1927, 1920, 3132, 6952, 17075, 1930, 28355, 13926, 3838, 3]}, "items": [{"id": "p_11", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_12", "content": "bradyarrhythmias [SEP] nditions which might have predisposed him to the development of bradyarrhythmias; and, thus, this probably represented a true idiosyncrasy to li", "tokenized_content": [2, 20152, 23246, 15519, 3, 8026, 2092, 1036, 2154, 3284, 2162, 23002, 1007, 13135, 1942, 1920, 2740, 1927, 20152, 23246, 15519, 31, 1930, 16, 2842, 16, 2052, 6226, 5960, 43, 6228, 3]}, "items": [{"id": "p_12", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_13", "content": "Suxamethonium [SEP] Suxamethonium infusion rate and observed fasciculations. A dose-response stud", "tokenized_content": [2, 2020, 11414, 23568, 15414, 3, 2020, 11414, 23568, 15414, 7386, 2769, 1930, 2528, 29990, 18021, 6055, 1036, 18, 43, 3253, 17, 2644, 2060, 3]}, "items": [{"id": "p_13", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_14", "content": "fasciculations [SEP] Suxamethonium infusion rate and observed fasciculations. A dose-response study.", "tokenized_content": [2, 29990, 18021, 6055, 1036, 3, 2020, 11414, 23568, 15414, 7386, 2769, 1930, 2528, 29990, 18021, 6055, 1036, 18, 43, 3253, 17, 2644, 2161, 18, 3]}, "items": [{"id": "p_14", "content": "Fasciculation [SEP] Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations can often by visualized and take the for", "score": 1, "type": null, "tokenized_content": [2, 29990, 18021, 6055, 3, 28493, 8332, 1927, 1920, 3760, 6989, 29882, 2007, 43, 4842, 5344, 18, 29990, 18021, 6055, 1036, 2112, 3868, 2007, 8559, 1930, 6132, 1920, 1958, 3]}]}
{"query": {"id": "q_15", "content": "Suxamethonium chloride [SEP] Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.2", "tokenized_content": [2, 2020, 11414, 23568, 15414, 9140, 3, 2020, 11414, 23568, 15414, 9140, 12, 2966, 13, 1982, 5254, 51, 18, 64, 18, 1942, 3480, 4160, 5129, 2019, 3798, 3389, 30, 20, 18, 3]}, "items": [{"id": "p_15", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_16", "content": "Sch [SEP] Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.25 mg ", "tokenized_content": [2, 2966, 3, 2020, 11414, 23568, 15414, 9140, 12, 2966, 13, 1982, 5254, 51, 18, 64, 18, 1942, 3480, 4160, 5129, 2019, 3798, 3389, 30, 20, 18, 2637, 2786, 3]}, "items": [{"id": "p_16", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_17", "content": "tetanic [SEP]  was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when Sch 120 mg was exceeded.", "tokenized_content": [2, 9717, 19510, 3, 1982, 16087, 3108, 2469, 2276, 1982, 2239, 12330, 2644, 1942, 9717, 19510, 4177, 1927, 1920, 24630, 5507, 2014, 2469, 2966, 6103, 2786, 1982, 13862, 18, 3]}, "items": [{"id": "p_17", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_18", "content": "Fasciculations [SEP] eded. Six additional patients received a 30-mg i.v. bolus dose. Fasciculations in six areas of the body were scored from 0 to 3 and summated a", "tokenized_content": [2, 29990, 18021, 6055, 1036, 3, 3347, 1919, 18, 3798, 3281, 2132, 4004, 43, 2627, 17, 2786, 51, 18, 64, 18, 14840, 3253, 18, 29990, 18021, 6055, 1036, 1922, 3798, 3957, 3]}, "items": [{"id": "p_18", "content": "Fasciculation [SEP] Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations can often by visualized and take the for", "score": 1, "type": null, "tokenized_content": [2, 29990, 18021, 6055, 3, 28493, 8332, 1927, 1920, 3760, 6989, 29882, 2007, 43, 4842, 5344, 18, 29990, 18021, 6055, 1036, 2112, 3868, 2007, 8559, 1930, 6132, 1920, 1958, 3]}]}
{"query": {"id": "q_19", "content": "fasciculation [SEP] eas of the body were scored from 0 to 3 and summated as a total fasciculation score. The times to first fasciculation, twitch suppression and", "tokenized_content": [2, 29990, 18021, 6055, 3, 4843, 1927, 1920, 3362, 1985, 9032, 2037, 20, 1942, 23, 1930, 4162, 1981, 1966, 43, 2698, 29990, 18021, 6055, 3593, 18, 1920, 3586, 1942, 2561, 29990, 3]}, "items": [{"id": "p_19", "content": "Fasciculation [SEP] Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations can often by visualized and take the for", "score": 1, "type": null, "tokenized_content": [2, 29990, 18021, 6055, 3, 28493, 8332, 1927, 1920, 3760, 6989, 29882, 2007, 43, 4842, 5344, 18, 29990, 18021, 6055, 1036, 2112, 3868, 2007, 8559, 1930, 6132, 1920, 1958, 3]}]}
{"query": {"id": "q_20", "content": "twitch [SEP]  a total fasciculation score. The times to first fasciculation, twitch suppression and tetanus suppression were inversely related to t", "tokenized_content": [2, 21596, 3, 43, 2698, 29990, 18021, 6055, 3593, 18, 1920, 3586, 1942, 2561, 29990, 18021, 6055, 16, 21596, 6412, 1930, 25608, 6412, 1985, 12442, 2712, 1942, 62, 3]}, "items": [{"id": "p_20", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_21", "content": "tetanus [SEP] score. The times to first fasciculation, twitch suppression and tetanus suppression were inversely related to the infusion rates. Fasci", "tokenized_content": [2, 25608, 3, 3593, 18, 1920, 3586, 1942, 2561, 29990, 18021, 6055, 16, 21596, 6412, 1930, 25608, 6412, 1985, 12442, 2712, 1942, 1920, 7386, 3389, 18, 29990, 3]}, "items": [{"id": "p_21", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_22", "content": "Galanthamine hydrobromide [SEP] Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of t", "tokenized_content": [2, 5179, 7744, 3812, 3290, 18474, 16408, 1021, 3, 5179, 7744, 3812, 3290, 18474, 16408, 1021, 16, 43, 4872, 8290, 5851, 12074, 21343, 2838, 16, 1922, 1920, 2311, 1927, 62, 3]}, "items": [{"id": "p_22", "content": "Galantamine [SEP] A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor tha", "score": 1, "type": null, "tokenized_content": [2, 5179, 23200, 25157, 3, 43, 7334, 25360, 3595, 2037, 3990, 21512, 22650, 18, 2176, 1977, 2435, 1922, 5179, 7744, 1957, 1930, 2303, 2150, 26029, 12191, 3825, 1972, 3336, 18, 2176, 1977, 43, 15440, 2156, 7124, 4127, 4106, 21513, 3]}]}
{"query": {"id": "q_23", "content": "scopolamine [SEP] cholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine).", "tokenized_content": [2, 25392, 10173, 25157, 3, 15440, 2156, 7124, 4127, 2838, 16, 1922, 1920, 2311, 1927, 1920, 4101, 2564, 1927, 25392, 10173, 25157, 12, 4527, 17413, 2912, 13, 18, 3]}, "items": [{"id": "p_23", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_24", "content": "Hyoscine [SEP] e drug, in the treatment of the central effects of scopolamine (Hyoscine).", "tokenized_content": [2, 4527, 17413, 2912, 3, 47, 2838, 16, 1922, 1920, 2311, 1927, 1920, 4101, 2564, 1927, 25392, 10173, 25157, 12, 4527, 17413, 2912, 13, 18, 3]}, "items": [{"id": "p_24", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_25", "content": "Galanthamine hydrobromide [SEP] Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-br", "tokenized_content": [2, 5179, 7744, 3812, 3290, 18474, 16408, 1021, 3, 5179, 7744, 3812, 3290, 18474, 16408, 1021, 16, 1925, 5851, 12074, 21343, 2838, 7131, 1927, 19879, 1920, 2877, 17, 2387, 3]}, "items": [{"id": "p_25", "content": "Galantamine [SEP] A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor tha", "score": 1, "type": null, "tokenized_content": [2, 5179, 23200, 25157, 3, 43, 7334, 25360, 3595, 2037, 3990, 21512, 22650, 18, 2176, 1977, 2435, 1922, 5179, 7744, 1957, 1930, 2303, 2150, 26029, 12191, 3825, 1972, 3336, 18, 2176, 1977, 43, 15440, 2156, 7124, 4127, 4106, 21513, 3]}]}
{"query": {"id": "q_26", "content": "scopolamine [SEP] barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine a", "tokenized_content": [2, 25392, 10173, 25157, 3, 7104, 16, 1982, 2251, 1922, 43, 2774, 7530, 4101, 2564, 1927, 25392, 10173, 25157, 12, 4527, 17413, 2912, 13, 17612, 5360, 2106, 18, 2176, 1977, 4872, 3]}, "items": [{"id": "p_26", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_27", "content": "hyoscine [SEP] used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used", "tokenized_content": [2, 4527, 17413, 2912, 3, 2251, 1922, 43, 2774, 7530, 4101, 2564, 1927, 25392, 10173, 25157, 12, 4527, 17413, 2912, 13, 17612, 5360, 2106, 18, 2176, 1977, 4872, 8290, 2254, 2861, 3]}, "items": [{"id": "p_27", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_28", "content": "overdosage [SEP] patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used in anaesthe", "tokenized_content": [2, 17612, 5360, 2106, 3, 2774, 7530, 4101, 2564, 1927, 25392, 10173, 25157, 12, 4527, 17413, 2912, 13, 17612, 5360, 2106, 18, 2176, 1977, 4872, 8290, 2254, 2861, 2259, 29043, 2053, 3]}, "items": [{"id": "p_28", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_29", "content": "physostigmine [SEP]  of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used in anaesthesia to reverse the non-depolarizing neur", "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 1927, 25392, 10173, 25157, 12, 4527, 17413, 2912, 13, 17612, 5360, 2106, 18, 2176, 1977, 4872, 8290, 2254, 2861, 2259, 29043, 2053, 1930, 1977, 2251, 3]}, "items": [{"id": "p_29", "content": "Physostigmine [SEP] A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also c", "score": 1, "type": null, "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 1988, 1977, 6221, 14504, 2596, 5726, 18, 2176, 2112, 1998, 3730, 12259, 1954, 1942, 1920, 16911, 1019, 18, 2176, 2222, 45, 3]}]}
{"query": {"id": "q_30", "content": "lithium [SEP] Effects of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats.", "tokenized_content": [2, 14330, 3, 2564, 1927, 22712, 2128, 6570, 5653, 1930, 2149, 2213, 6788, 1990, 14330, 17, 2719, 3724, 4604, 4574, 1922, 3615, 18, 3]}, "items": [{"id": "p_30", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_31", "content": "chronic renal failure [SEP] s of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats.", "tokenized_content": [2, 3724, 4604, 4574, 3, 61, 1927, 22712, 2128, 6570, 5653, 1930, 2149, 2213, 6788, 1990, 14330, 17, 2719, 3724, 4604, 4574, 1922, 3615, 18, 3]}, "items": [{"id": "p_31", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_32", "content": "lithium [SEP] Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding", "tokenized_content": [2, 14330, 3, 3615, 1956, 14330, 17, 2719, 15582, 1985, 6243, 1942, 2149, 2213, 12, 4688, 13, 6788, 3]}, "items": [{"id": "p_32", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_33", "content": "nephropathy [SEP] Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX", "tokenized_content": [2, 15582, 3, 3615, 1956, 14330, 17, 2719, 15582, 1985, 6243, 1942, 2149, 2213, 12, 4688, 13, 6788, 16, 22712, 2128, 6570, 5653, 12, 27578, 3]}, "items": [{"id": "p_33", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_34", "content": "renal failure [SEP] to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a lithium-containing diet ", "tokenized_content": [2, 4604, 4574, 3, 1942, 4769, 11655, 4194, 6870, 6003, 1930, 2520, 4380, 1927, 4604, 4574, 18, 12203, 4232, 15668, 3615, 1985, 5788, 43, 14330, 17, 3165, 3986, 3]}, "items": [{"id": "p_34", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_35", "content": "Li [SEP] sed a fall in filtration fraction and an increase in fractional Li excretion. Lithium also caused proteinuria and systolic hyperte", "tokenized_content": [2, 2336, 3, 6276, 43, 6462, 1922, 10347, 3906, 1930, 1925, 2760, 1922, 14436, 2336, 11093, 18, 14330, 2222, 4189, 15831, 1930, 8541, 4506, 1021, 3]}, "items": [{"id": "p_35", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_36", "content": "Lithium [SEP] filtration fraction and an increase in fractional Li excretion. Lithium also caused proteinuria and systolic hypertension in absence of", "tokenized_content": [2, 14330, 3, 10347, 3906, 1930, 1925, 2760, 1922, 14436, 2336, 11093, 18, 14330, 2222, 4189, 15831, 1930, 8541, 5579, 1922, 3905, 1927, 3]}, "items": [{"id": "p_36", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_37", "content": "proteinuria [SEP] and an increase in fractional Li excretion. Lithium also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP ", "tokenized_content": [2, 15831, 3, 1930, 1925, 2760, 1922, 14436, 2336, 11093, 18, 14330, 2222, 4189, 15831, 1930, 8541, 5579, 1922, 3905, 1927, 19268, 25081, 18, 4688, 3]}, "items": [{"id": "p_37", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_38", "content": "hypertension [SEP] onal Li excretion. Lithium also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP failed to accentuante prog", "tokenized_content": [2, 5579, 3, 1990, 1923, 2336, 11093, 18, 14330, 2222, 4189, 15831, 1930, 8541, 5579, 1922, 3905, 1927, 19268, 25081, 18, 4688, 6617, 1942, 26884, 13785, 2057, 1965, 1029, 3]}, "items": [{"id": "p_38", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_39", "content": "glomerulosclerosis [SEP] also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP failed to accentuante progression of renal failure and in f", "tokenized_content": [2, 19268, 25081, 3, 2222, 4189, 15831, 1930, 8541, 5579, 1922, 3905, 1927, 19268, 25081, 18, 4688, 6617, 1942, 26884, 13785, 2057, 4380, 1927, 4604, 4574, 1930, 1922, 48, 3]}, "items": [{"id": "p_39", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_40", "content": "creatinine [SEP]  failure and in fact tended to increase GFR and decrease plasma creatinine levels in lithium pretreated rats. NX caused an additive deteri", "tokenized_content": [2, 9374, 3, 4574, 1930, 1922, 2371, 10587, 1942, 2760, 15316, 1930, 3714, 3582, 9374, 2428, 1922, 14330, 12152, 3615, 18, 27578, 4189, 1925, 10359, 10641, 1033, 3]}, "items": [{"id": "p_40", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_41", "content": "chronic renal failure [SEP] roteinuria and arterial systolic hypertension. In this model of chronic renal failure the decline in GFR is not accompanied by a corresponding fall i", "tokenized_content": [2, 3724, 4604, 4574, 3, 5337, 14818, 8754, 1930, 6624, 8541, 5579, 18, 1922, 2052, 2322, 1927, 3724, 4604, 4574, 1920, 6859, 1922, 15316, 1977, 2084, 7936, 2007, 43, 3980, 6462, 3]}, "items": [{"id": "p_41", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_42", "content": "Crohn's disease [SEP] Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive propert", "tokenized_content": [2, 17563, 11, 61, 2573, 3, 2311, 1927, 17563, 11, 61, 2573, 1956, 10630, 12546, 2687, 30, 1925, 7267, 1956, 12910, 3405, 1031, 3]}, "items": [{"id": "p_42", "content": "Crohn Disease [SEP] A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM", "score": 1, "type": null, "tokenized_content": [2, 17563, 2573, 3, 43, 3724, 30306, 4531, 1988, 2278, 8156, 2967, 3131, 1927, 1920, 15486, 6482, 2037, 11701, 1942, 1925, 1957, 16, 6969, 2435, 1922, 1920, 19269, 3]}]}
{"query": {"id": "q_43", "content": "fusidic acid [SEP] Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyc", "tokenized_content": [2, 10630, 12546, 2687, 3, 2311, 1927, 17563, 11, 61, 2573, 1956, 10630, 12546, 2687, 30, 1925, 7267, 1956, 12910, 3879, 2551, 1942, 21309, 3]}, "items": [{"id": "p_43", "content": "Fusidic Acid [SEP] An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting tra", "score": 1, "type": null, "tokenized_content": [2, 10630, 12546, 2687, 3, 1925, 7267, 3937, 2037, 1920, 12670, 13150, 1927, 10630, 9734, 28014, 2053, 1989, 18, 12, 2037, 14556, 3867, 16, 2513, 1963, 3347, 13, 18, 2176, 8016, 2007, 7918, 3390, 3]}]}
{"query": {"id": "q_44", "content": "cyclosporin [SEP] cid: an antibiotic with immunosuppressive properties similar to cyclosporin.", "tokenized_content": [2, 17640, 1921, 3, 18069, 30, 1925, 7267, 1956, 12910, 3879, 2551, 1942, 17640, 1921, 18, 3]}, "items": [{"id": "p_44", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_45", "content": "cyclosporin [SEP] h T-cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for ", "tokenized_content": [2, 17640, 1921, 3, 50, 62, 17, 2024, 2487, 12910, 2564, 2551, 1942, 2690, 1927, 17640, 1921, 18, 2882, 1927, 1920, 2942, 1958, 1920, 2740, 1927, 2814, 4930, 1958, 3]}, "items": [{"id": "p_45", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_46", "content": "Crohn's disease [SEP] . Because of the need for the development of new treatments for Crohn's disease, a pilot study was undertaken to estimate the pharmacodynamics ", "tokenized_content": [2, 17563, 11, 61, 2573, 3, 18, 2882, 1927, 1920, 2942, 1958, 1920, 2740, 1927, 2814, 4930, 1958, 17563, 11, 61, 2573, 16, 43, 9404, 2161, 1982, 10466, 1942, 5383, 1920, 3]}, "items": [{"id": "p_46", "content": "Crohn Disease [SEP] A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM", "score": 1, "type": null, "tokenized_content": [2, 17563, 2573, 3, 43, 3724, 30306, 4531, 1988, 2278, 8156, 2967, 3131, 1927, 1920, 15486, 6482, 2037, 11701, 1942, 1925, 1957, 16, 6969, 2435, 1922, 1920, 19269, 3]}]}
{"query": {"id": "q_47", "content": "fusidic acid [SEP] undertaken to estimate the pharmacodynamics and tolerability of fusidic acid treatment in chronic active, therapy-resistant patients. Eight ", "tokenized_content": [2, 10630, 12546, 2687, 3, 10466, 1942, 5383, 1920, 24358, 1036, 1930, 17934, 1927, 10630, 12546, 2687, 2311, 1922, 3724, 3500, 16, 3181, 17, 4910, 2132, 18, 5066, 3]}, "items": [{"id": "p_47", "content": "Fusidic Acid [SEP] An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting tra", "score": 1, "type": null, "tokenized_content": [2, 10630, 12546, 2687, 3, 1925, 7267, 3937, 2037, 1920, 12670, 13150, 1927, 10630, 9734, 28014, 2053, 1989, 18, 12, 2037, 14556, 3867, 16, 2513, 1963, 3347, 13, 18, 2176, 8016, 2007, 7918, 3390, 3]}]}
{"query": {"id": "q_48", "content": "Fusidic acid [SEP] Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects", "tokenized_content": [2, 10630, 12546, 2687, 3, 10630, 12546, 2687, 1977, 1925, 7267, 1956, 62, 17, 2024, 2487, 12910, 2564, 3]}, "items": [{"id": "p_48", "content": "Fusidic Acid [SEP] An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting tra", "score": 1, "type": null, "tokenized_content": [2, 10630, 12546, 2687, 3, 1925, 7267, 3937, 2037, 1920, 12670, 13150, 1927, 10630, 9734, 28014, 2053, 1989, 18, 12, 2037, 14556, 3867, 16, 2513, 1963, 3347, 13, 18, 2176, 8016, 2007, 7918, 3390, 3]}]}
{"query": {"id": "q_49", "content": "nausea [SEP] cts, but dose reduction was required in two patients because of nausea. Biochemically, an increase in alkaline phosphatases was noted ", "tokenized_content": [2, 13759, 3, 15359, 16, 2308, 3253, 3378, 1982, 3414, 1922, 2288, 2132, 2882, 1927, 13759, 18, 25839, 16, 1925, 2760, 1922, 10746, 19131, 1982, 5040, 3]}, "items": [{"id": "p_49", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_50", "content": "inflammatory bowel disease [SEP]  rationale for the use of fusidic acid at the cytokine level in inflammatory bowel disease, we suggest that the role of this treatment should be further i", "tokenized_content": [2, 3769, 9472, 2573, 3, 13202, 1958, 1920, 2485, 1927, 10630, 12546, 2687, 2019, 1920, 6137, 2237, 1922, 3769, 9472, 2573, 16, 2038, 3220, 1988, 1920, 2770, 1927, 2052, 2311, 3066, 3]}, "items": [{"id": "p_50", "content": "Inflammatory Bowel Diseases [SEP] Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes C", "score": 1, "type": null, "tokenized_content": [2, 3769, 9472, 3902, 3, 3724, 16, 2447, 17, 2487, 4531, 1927, 1920, 8375, 6482, 18, 10383, 2278, 1998, 3299, 2014, 4813, 18, 2052, 2576, 5921, 45, 3]}]}
{"query": {"id": "q_51", "content": "myocardial injury [SEP] Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers.", "tokenized_content": [2, 6497, 4047, 3, 15894, 4158, 3095, 1927, 6497, 4047, 1922, 7652, 2169, 13123, 9045, 7764, 5675, 18, 3]}, "items": [{"id": "p_51", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_52", "content": "cocaine [SEP] c evidence of myocardial injury in psychiatrically hospitalized cocaine abusers.", "tokenized_content": [2, 9045, 3, 45, 3095, 1927, 6497, 4047, 1922, 7652, 2169, 13123, 9045, 7764, 5675, 18, 3]}, "items": [{"id": "p_52", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_53", "content": "cocaine [SEP] The electrocardiograms (ECG) of 99 cocaine-abusing patients were compared with the ECGs of 50 schizophreni", "tokenized_content": [2, 9045, 3, 1920, 22477, 1036, 12, 11497, 13, 1927, 4922, 9045, 17, 2186, 16435, 2132, 1985, 2452, 1956, 1920, 11497, 1036, 1927, 2761, 7603, 1033, 3]}, "items": [{"id": "p_53", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_54", "content": "schizophrenic [SEP] f 99 cocaine-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the cocaine abusers and none of the control", "tokenized_content": [2, 28247, 3, 48, 4922, 9045, 17, 2186, 16435, 2132, 1985, 2452, 1956, 1920, 11497, 1036, 1927, 2761, 28247, 3562, 18, 14483, 1927, 1920, 9045, 7764, 5675, 1930, 6046, 1927, 1920, 3]}, "items": [{"id": "p_54", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_55", "content": "myocardial injury [SEP] busers and none of the controls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch b", "tokenized_content": [2, 6497, 4047, 3, 11730, 2045, 1930, 6046, 1927, 1920, 3562, 2430, 11497, 3095, 1927, 2228, 6497, 4047, 3608, 1966, 6497, 8358, 16, 7716, 16, 1930, 14142, 6089, 44, 3]}, "items": [{"id": "p_55", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_56", "content": "myocardial infarction [SEP] ls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block.", "tokenized_content": [2, 6497, 8358, 3, 6639, 2430, 11497, 3095, 1927, 2228, 6497, 4047, 3608, 1966, 6497, 8358, 16, 7716, 16, 1930, 14142, 6089, 3367, 18, 3]}, "items": [{"id": "p_56", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_57", "content": "ischemia [SEP] significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block.", "tokenized_content": [2, 7716, 3, 2228, 6497, 4047, 3608, 1966, 6497, 8358, 16, 7716, 16, 1930, 14142, 6089, 3367, 18, 3]}, "items": [{"id": "p_57", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_58", "content": "bundle branch block [SEP] ocardial injury defined as myocardial infarction, ischemia, and bundle branch block.", "tokenized_content": [2, 14142, 6089, 3367, 3, 5084, 15152, 4047, 3608, 1966, 6497, 8358, 16, 7716, 16, 1930, 14142, 6089, 3367, 18, 3]}, "items": [{"id": "p_58", "content": "Bundle-Branch Block [SEP] A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BU", "score": 1, "type": null, "tokenized_content": [2, 14142, 17, 6089, 3367, 3, 43, 2386, 1927, 4003, 3367, 1922, 2154, 1920, 8287, 4177, 1927, 4003, 21008, 1977, 20291, 2019, 3108, 2340, 1927, 1920, 11208, 1927, 3168, 3]}]}
{"query": {"id": "q_59", "content": "Sulpiride [SEP] Sulpiride-induced tardive dystonia.", "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 9596, 10984, 20332, 1021, 17, 2719, 14517, 7408, 1961, 23357, 18, 3]}, "items": [{"id": "p_59", "content": "Sulpiride [SEP] A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.", "score": 1, "type": null, "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 43, 7964, 8631, 17, 3148, 8151, 18, 2176, 2258, 2252, 2251, 25058, 1966, 1925, 14183, 16, 17581, 16, 1930, 1966, 43, 15486, 8379, 18, 3]}]}
{"query": {"id": "q_60", "content": "tardive dystonia [SEP] Sulpiride-induced tardive dystonia.", "tokenized_content": [2, 14517, 7408, 1961, 23357, 3, 9596, 10984, 20332, 1021, 17, 2719, 14517, 7408, 1961, 23357, 18, 3]}, "items": [{"id": "p_60", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_61", "content": "Sulpiride [SEP] Sulpiride is a selective D2-receptor antagonist with antipsychotic and an", "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 9596, 10984, 20332, 1021, 1977, 43, 5328, 8631, 17, 3148, 8151, 1956, 17581, 1930, 1925, 3]}, "items": [{"id": "p_61", "content": "Sulpiride [SEP] A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.", "score": 1, "type": null, "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 43, 7964, 8631, 17, 3148, 8151, 18, 2176, 2258, 2252, 2251, 25058, 1966, 1925, 14183, 16, 17581, 16, 1930, 1966, 43, 15486, 8379, 18, 3]}]}
{"query": {"id": "q_62", "content": "antidepressant [SEP] de is a selective D2-receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyram", "tokenized_content": [2, 14183, 3, 2028, 1977, 43, 5328, 8631, 17, 3148, 8151, 1956, 17581, 1930, 14183, 3879, 18, 2876, 6370, 6212, 1942, 1998, 3294, 1927, 21346, 3553, 1976, 3]}, "items": [{"id": "p_62", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_63", "content": "sulpiride [SEP] gh initially thought to be free of extrapyramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported ", "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 6101, 6370, 6212, 1942, 1998, 3294, 1927, 21346, 3553, 25238, 1923, 4159, 2564, 16, 9596, 10984, 20332, 1021, 17, 2719, 14517, 7408, 1961, 3890, 26682, 3]}, "items": [{"id": "p_63", "content": "Sulpiride [SEP] A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.", "score": 1, "type": null, "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 43, 7964, 8631, 17, 3148, 8151, 18, 2176, 2258, 2252, 2251, 25058, 1966, 1925, 14183, 16, 17581, 16, 1930, 1966, 43, 15486, 8379, 18, 3]}]}
{"query": {"id": "q_64", "content": "tardive dyskinesia [SEP] ht to be free of extrapyramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a ", "tokenized_content": [2, 14517, 7408, 1961, 3890, 26682, 3, 5334, 1942, 1998, 3294, 1927, 21346, 3553, 25238, 1923, 4159, 2564, 16, 9596, 10984, 20332, 1021, 17, 2719, 14517, 7408, 1961, 3890, 26682, 1930, 3]}, "items": [{"id": "p_64", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_65", "content": "parkinsonism [SEP] yramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37-year-old man w", "tokenized_content": [2, 26214, 3, 13031, 25238, 1923, 4159, 2564, 16, 9596, 10984, 20332, 1021, 17, 2719, 14517, 7408, 1961, 3890, 26682, 1930, 26214, 2162, 2252, 2568, 14647, 18, 2038, 3942, 43, 3191, 3]}, "items": [{"id": "p_65", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_66", "content": "dystonia [SEP] We studied a 37-year-old man who developed persistent segmental dystonia within 2 months after starting sulpiride therapy. We could not ", "tokenized_content": [2, 23357, 3, 2038, 3942, 43, 3191, 17, 2476, 17, 4156, 2323, 2746, 3530, 7733, 16294, 23357, 2651, 22, 3221, 2256, 6801, 9596, 10984, 20332, 1021, 3181, 18, 2038, 2578, 2084, 3]}, "items": [{"id": "p_66", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_67", "content": "tardive dystonia [SEP] py. We could not find any previous reports of sulpiride-induced tardive dystonia.", "tokenized_content": [2, 14517, 7408, 1961, 23357, 3, 6085, 18, 2038, 2578, 2084, 5387, 2967, 2555, 4710, 1927, 9596, 10984, 20332, 1021, 17, 2719, 14517, 7408, 1961, 23357, 18, 3]}, "items": [{"id": "p_67", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_68", "content": "auditory toxicity [SEP] Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine.", "tokenized_content": [2, 8401, 5532, 3, 10046, 1930, 8401, 5532, 1922, 3243, 13968, 1954, 6756, 2132, 5962, 2270, 2070, 19481, 11414, 25157, 18, 3]}, "items": [{"id": "p_68", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_69", "content": "desferrioxamine [SEP] Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine.", "tokenized_content": [2, 2270, 2070, 19481, 11414, 25157, 3, 10046, 1930, 8401, 5532, 1922, 3243, 13968, 1954, 6756, 2132, 5962, 2270, 2070, 19481, 11414, 25157, 18, 3]}, "items": [{"id": "p_69", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_70", "content": "desferrioxamine [SEP]  an 18-month period of study 41 hemodialyzed patients receiving desferrioxamine (10-40 mg/kg BW/3 times weekly) for the first time were monitor", "tokenized_content": [2, 2270, 2070, 19481, 11414, 25157, 3, 1925, 2654, 17, 2935, 3047, 1927, 2161, 4353, 3243, 13968, 1954, 6756, 2132, 5962, 2270, 2070, 19481, 11414, 25157, 12, 2119, 17, 3040, 2786, 3]}, "items": [{"id": "p_70", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_71", "content": "auditory toxicity [SEP] l toxicity. 6 patients presented clinical symptoms of visual or auditory toxicity. Moreover, detailed ophthalmologic and audiologic studies discl", "tokenized_content": [2, 8401, 5532, 3, 54, 5532, 18, 26, 2132, 3549, 2535, 3601, 1927, 3737, 2014, 8401, 5532, 18, 3950, 16, 5720, 14554, 4467, 1930, 18609, 22284, 1935, 2351, 8973, 3]}, "items": [{"id": "p_71", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_72", "content": "Visual toxicity [SEP] tudies disclosed abnormalities in 7 more asymptomatic patients. Visual toxicity was of retinal origin and was characterized by a tritan-type dy", "tokenized_content": [2, 3737, 5532, 3, 9037, 7408, 1918, 20485, 6754, 1922, 27, 2253, 9978, 2132, 18, 3737, 5532, 1982, 1927, 6943, 4853, 1930, 1982, 4378, 2007, 43, 5083, 3285, 17, 2601, 6433, 3]}, "items": [{"id": "p_72", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_73", "content": "a loss of visual acuity [SEP] ized by a tritan-type dyschromatopsy, sometimes associated with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characte", "tokenized_content": [2, 43, 3257, 1927, 3737, 12320, 3, 25455, 1919, 2007, 43, 5083, 3285, 17, 2601, 3890, 2072, 2018, 8286, 9196, 16, 8929, 2458, 1956, 43, 3257, 1927, 3737, 12320, 1930, 12905, 3]}, "items": [{"id": "p_73", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_74", "content": "pigmentary retinal deposits [SEP] omatopsy, sometimes associated with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequenc", "tokenized_content": [2, 12905, 2141, 6943, 14371, 3, 7254, 8286, 9196, 16, 8929, 2458, 1956, 43, 3257, 1927, 3737, 12320, 1930, 12905, 2141, 6943, 14371, 18, 8401, 5532, 1982, 4378, 2007, 43, 3953, 3]}, "items": [{"id": "p_74", "content": "Retinal Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6943, 3902, 3, 3]}]}
{"query": {"id": "q_75", "content": "Auditory toxicity [SEP] d with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequency neurosensorial he", "tokenized_content": [2, 8401, 5532, 3, 46, 1956, 43, 3257, 1927, 3737, 12320, 1930, 12905, 2141, 6943, 14371, 18, 8401, 5532, 1982, 4378, 2007, 43, 3953, 17, 1942, 2149, 17, 3528, 7318, 13433, 3]}, "items": [{"id": "p_75", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_76", "content": "neurosensorial hearing loss [SEP] Auditory toxicity was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. Desferrioxamine withdr", "tokenized_content": [2, 7318, 13433, 2086, 8512, 3257, 3, 8401, 5532, 1982, 4378, 2007, 43, 3953, 17, 1942, 2149, 17, 3528, 7318, 13433, 2086, 8512, 3257, 1930, 1920, 5709, 1982, 1927, 1920, 15865, 3]}, "items": [{"id": "p_76", "content": "Hearing Loss, Sensorineural [SEP] Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 6443, 2053, 2741, 3, 8512, 3257, 3864, 2037, 4293, 1942, 1920, 23310, 1930, 1920, 6443, 2053, 2741, 5362, 2154, 14958, 23125, 6844, 1920, 22584, 1930, 7464, 3]}]}
{"query": {"id": "q_77", "content": "Desferrioxamine [SEP] sensorial hearing loss and the lesion was of the cochlear type. Desferrioxamine withdrawal resulted in a complete recovery of visual function i", "tokenized_content": [2, 2270, 2070, 19481, 11414, 25157, 3, 6443, 2086, 8512, 3257, 1930, 1920, 5709, 1982, 1927, 1920, 15865, 2601, 18, 2270, 2070, 19481, 11414, 25157, 9594, 4306, 1922, 43, 4080, 5241, 3]}, "items": [{"id": "p_77", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_78", "content": "hearing loss [SEP] ty was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. Desferrioxamine withdr", "tokenized_content": [2, 8512, 3257, 3, 6227, 1982, 4378, 2007, 43, 3953, 17, 1942, 2149, 17, 3528, 7318, 13433, 2086, 8512, 3257, 1930, 1920, 5709, 1982, 1927, 1920, 15865, 2601, 18, 2270, 2070, 3]}, "items": [{"id": "p_78", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_79", "content": "toxicity [SEP]  for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual or auditory t", "tokenized_content": [2, 5532, 3, 1958, 1920, 2561, 2367, 1985, 7027, 1958, 3805, 1927, 18609, 7400, 2224, 5532, 18, 26, 2132, 3549, 2535, 3601, 1927, 3737, 2014, 8401, 62, 3]}, "items": [{"id": "p_79", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_80", "content": "Myasthenia gravis [SEP] Myasthenia gravis presenting as weakness after magnesium administration.", "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 3057, 27618, 8572, 12413, 1937, 8326, 1966, 12175, 2256, 13148, 4183, 18, 3]}, "items": [{"id": "p_80", "content": "Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai", "score": 1, "type": null, "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 43, 4770, 1927, 15829, 5303, 4378, 2007, 12175, 1927, 13598, 1930, 7345, 7848, 18, 15510, 6554, 8770, 1033, 3]}]}
{"query": {"id": "q_81", "content": "magnesium [SEP] Myasthenia gravis presenting as weakness after magnesium administration.", "tokenized_content": [2, 13148, 3, 3057, 27618, 8572, 12413, 1937, 8326, 1966, 12175, 2256, 13148, 4183, 18, 3]}, "items": [{"id": "p_81", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_82", "content": "neuromuscular disease [SEP] We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium ad", "tokenized_content": [2, 15829, 2573, 3, 2038, 3942, 43, 2774, 1956, 2239, 3432, 4403, 1927, 15829, 2573, 2746, 7935, 13224, 10264, 13229, 6541, 1935, 2256, 20301, 13148, 2041, 3]}, "items": [{"id": "p_82", "content": "Neuromuscular Diseases [SEP] A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manif", "score": 1, "type": null, "tokenized_content": [2, 15829, 3902, 3, 43, 3335, 2576, 17527, 2826, 4842, 7428, 2573, 31, 5009, 7580, 2433, 3902, 31, 1930, 4908, 12330, 3902, 18, 6747, 3]}]}
{"query": {"id": "q_83", "content": "quadriplegic [SEP]  no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The", "tokenized_content": [2, 10264, 13229, 6541, 1935, 3, 2239, 3432, 4403, 1927, 15829, 2573, 2746, 7935, 13224, 10264, 13229, 6541, 1935, 2256, 20301, 13148, 4183, 1958, 17494, 18, 1920, 3]}, "items": [{"id": "p_83", "content": "Quadriplegia [SEP] Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHER", "score": 1, "type": null, "tokenized_content": [2, 10264, 13229, 6541, 2126, 3, 4010, 2014, 4080, 3257, 1927, 4842, 2347, 1922, 2136, 3006, 14054, 2154, 2278, 3211, 2037, 3068, 3902, 31, 6071, 6670, 3902, 31, 4709, 3]}]}
{"query": {"id": "q_84", "content": "magnesium [SEP] ular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentrat", "tokenized_content": [2, 13148, 3, 3570, 1933, 2573, 2746, 7935, 13224, 10264, 13229, 6541, 1935, 2256, 20301, 13148, 4183, 1958, 17494, 18, 1920, 3256, 13148, 2587, 1926, 3]}, "items": [{"id": "p_84", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_85", "content": "preeclampsia [SEP] ally quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3.0 mEq/L, which is usua", "tokenized_content": [2, 17494, 3, 2136, 1012, 10264, 13229, 6541, 1935, 2256, 20301, 13148, 4183, 1958, 17494, 18, 1920, 3256, 13148, 3110, 1982, 23, 18, 20, 25509, 19, 54, 16, 2154, 1977, 2022, 3]}, "items": [{"id": "p_85", "content": "Pre-Eclampsia [SEP] A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or with", "score": 1, "type": null, "tokenized_content": [2, 2097, 17, 24938, 3, 43, 9388, 1927, 5284, 16, 4378, 2007, 43, 2796, 1927, 3601, 2710, 5509, 5579, 1930, 15831, 1956, 2014, 1956, 3]}]}
{"query": {"id": "q_86", "content": "postsynaptic neuromuscular blockade [SEP] icant facilitation at rapid rates or after exercise, suggesting postsynaptic neuromuscular blockade. After her strength returned, repetitive stimulation was normal", "tokenized_content": [2, 13090, 15829, 9847, 3, 14784, 4905, 17477, 2019, 4052, 3389, 2014, 2256, 4975, 16, 3783, 13090, 15829, 9847, 18, 2256, 3656, 4568, 10418, 16, 12089, 4177, 1982, 2791, 3]}, "items": [{"id": "p_86", "content": "Neuromuscular Diseases [SEP] A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manif", "score": 1, "type": null, "tokenized_content": [2, 15829, 3902, 3, 43, 3335, 2576, 17527, 2826, 4842, 7428, 2573, 31, 5009, 7580, 2433, 3902, 31, 1930, 4908, 12330, 3902, 18, 6747, 3]}]}
{"query": {"id": "q_87", "content": "acetylcholine [SEP] ut single fiber EMG revealed increased jitter and blocking. Her acetylcholine receptor antibody level was markedly elevated. Although paralys", "tokenized_content": [2, 14561, 3, 11112, 2957, 6832, 13952, 3404, 2502, 14280, 3519, 1915, 1930, 7472, 18, 3656, 14561, 3148, 3533, 2237, 1982, 7686, 4664, 18, 2876, 11271, 2012, 3]}, "items": [{"id": "p_87", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_88", "content": "paralysis [SEP] choline receptor antibody level was markedly elevated. Although paralysis after magnesium administration has been described in patients w", "tokenized_content": [2, 18973, 3, 15440, 3148, 3533, 2237, 1982, 7686, 4664, 18, 2876, 18973, 2256, 13148, 4183, 2258, 2252, 2910, 1922, 2132, 65, 3]}, "items": [{"id": "p_88", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_89", "content": "myasthenia gravis [SEP] nesium administration has been described in patients with known myasthenia gravis, it has not previously been reported to be the initial or only ", "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 12100, 2457, 4183, 2258, 2252, 2910, 1922, 2132, 1956, 3171, 3057, 27618, 8572, 12413, 1937, 16, 2176, 2258, 2084, 3024, 2252, 2568, 1942, 1998, 3]}, "items": [{"id": "p_89", "content": "Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai", "score": 1, "type": null, "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 43, 4770, 1927, 15829, 5303, 4378, 2007, 12175, 1927, 13598, 1930, 7345, 7848, 18, 15510, 6554, 8770, 1033, 3]}]}
{"query": {"id": "q_90", "content": "disorder of neuromuscular transmission [SEP] ffects of magnesium should be suspected of having an underlying disorder of neuromuscular transmission.", "tokenized_content": [2, 4770, 1927, 15829, 5303, 3, 10735, 2284, 1927, 13148, 3066, 1998, 9407, 1927, 4537, 1925, 5030, 4770, 1927, 15829, 5303, 18, 3]}, "items": [{"id": "p_90", "content": "Neuromuscular Junction Diseases [SEP] Conditions characterized by impaired transmission of impulses at the NEUROMUSCULAR JUNCTION. This may result from disorders that", "score": 1, "type": null, "tokenized_content": [2, 15829, 6910, 3902, 3, 2961, 4378, 2007, 5761, 5303, 1927, 21896, 1036, 2019, 1920, 15829, 6910, 18, 2052, 2278, 3211, 2037, 4414, 1988, 3]}]}
{"query": {"id": "q_91", "content": "Chloroacetaldehyde [SEP] Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclo", "tokenized_content": [2, 10107, 7681, 8790, 3, 10107, 7681, 8790, 1930, 2496, 5100, 1942, 14984, 4575, 18068, 3349, 3145, 2409, 2311, 1956, 17009, 3]}, "items": [{"id": "p_91", "content": "chloroacetaldehyde [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10107, 7681, 8790, 3, 3]}]}
{"query": {"id": "q_92", "content": "cyclophosphamide [SEP] ehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication.", "tokenized_content": [2, 17135, 3, 12429, 2584, 1021, 1930, 2496, 5100, 1942, 14984, 4575, 18068, 3349, 3145, 2409, 2311, 1956, 17135, 2014, 2647, 1951, 6016, 16408, 1021, 18, 1925, 3599, 2161, 19, 3662, 3]}, "items": [{"id": "p_92", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_93", "content": "ifosfamide [SEP] bution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication.", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 2308, 2001, 1942, 14984, 4575, 18068, 3349, 3145, 2409, 2311, 1956, 17135, 2014, 2647, 1951, 6016, 16408, 1021, 18, 1925, 3599, 2161, 19, 3662, 3]}, "items": [{"id": "p_93", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_94", "content": "chloroacetaldehyde [SEP] Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatic", "tokenized_content": [2, 10107, 7681, 8790, 3, 2454, 1990, 2535, 2230, 16, 4168, 1988, 10107, 7681, 8790, 12, 20951, 13, 1977, 1925, 2715, 9483, 1927, 28905, 12813, 10614, 2053, 5521, 3857, 2002, 3]}, "items": [{"id": "p_94", "content": "chloroacetaldehyde [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10107, 7681, 8790, 3, 3]}]}
{"query": {"id": "q_95", "content": "CAA [SEP] Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an", "tokenized_content": [2, 20951, 3, 2454, 1990, 2535, 2230, 16, 4168, 1988, 10107, 7681, 8790, 12, 20951, 13, 1977, 1925, 2715, 9483, 1927, 28905, 12813, 10614, 2053, 5521, 3857, 2837, 16, 1925, 3]}, "items": [{"id": "p_95", "content": "chloroacetaldehyde [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10107, 7681, 8790, 3, 3]}]}
{"query": {"id": "q_96", "content": "hemorrhagic [SEP] out in order to elucidate the role of CAA in the development of hemorrhagic cystitis. The data demonstrate that CAA after i.v. administrati", "tokenized_content": [2, 16052, 3, 2397, 1922, 3238, 1942, 9970, 1920, 2770, 1927, 20951, 1922, 1920, 2740, 1927, 16052, 9446, 3678, 18, 1920, 2230, 4504, 1988, 20951, 2256, 51, 18, 64, 18, 10473, 3]}, "items": [{"id": "p_96", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_97", "content": "cystitis [SEP]  to elucidate the role of CAA in the development of hemorrhagic cystitis. The data demonstrate that CAA after i.v. administration does n", "tokenized_content": [2, 9446, 3678, 3, 1942, 9970, 1920, 2770, 1927, 20951, 1922, 1920, 2740, 1927, 16052, 9446, 3678, 18, 1920, 2230, 4504, 1988, 20951, 2256, 51, 18, 64, 18, 4183, 3731, 56, 3]}, "items": [{"id": "p_97", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_98", "content": "bladder damage [SEP] trate that CAA after i.v. administration does not contribute to bladder damage. When instilled directly into the bladder, CAA exerts urotoxic ", "tokenized_content": [2, 7821, 4293, 3, 3390, 2057, 1988, 20951, 2256, 51, 18, 64, 18, 4183, 3731, 2084, 4672, 1942, 7821, 4293, 18, 2469, 4766, 6297, 4103, 2460, 1920, 7821, 16, 20951, 14235, 3]}, "items": [{"id": "p_98", "content": "Urinary Bladder Diseases [SEP] Pathological processes of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 3902, 3, 6598, 4028, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_99", "content": "mesna [SEP] xic effects, it is, however, susceptible to detoxification with mesna.", "tokenized_content": [2, 4438, 2175, 3, 11551, 1030, 2564, 16, 2176, 1977, 16, 2406, 16, 7819, 1942, 18169, 1956, 4438, 2175, 18, 3]}, "items": [{"id": "p_99", "content": "Mesna [SEP] A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFA", "score": 1, "type": null, "tokenized_content": [2, 4438, 2175, 3, 43, 30011, 2199, 3547, 2251, 1942, 4625, 23182, 5532, 2007, 20862, 6926, 2037, 29128, 9969, 4820, 16, 2427, 1966, 2647, 1951, 6016, 3]}]}
{"query": {"id": "q_100", "content": "pain [SEP] Source of pain and primitive dysfunction in migraine: an identical site?", "tokenized_content": [2, 3594, 3, 4585, 1927, 3594, 1930, 18903, 5273, 1922, 13258, 30, 1925, 6119, 3200, 35, 3]}, "items": [{"id": "p_100", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_101", "content": "migraine [SEP] Source of pain and primitive dysfunction in migraine: an identical site?", "tokenized_content": [2, 13258, 3, 4585, 1927, 3594, 1930, 18903, 5273, 1922, 13258, 30, 1925, 6119, 3200, 35, 3]}, "items": [{"id": "p_101", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_102", "content": "migraine [SEP] Twenty common migraine patients received a one sided frontotemporal application of nit", "tokenized_content": [2, 13258, 3, 7639, 3059, 13258, 2132, 4004, 43, 2340, 11175, 27047, 2057, 6588, 6277, 4722, 1927, 7904, 3]}, "items": [{"id": "p_102", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_103", "content": "nitroglycerin [SEP] ine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double bli", "tokenized_content": [2, 8686, 14966, 1921, 3, 11116, 2132, 4004, 43, 2340, 11175, 27047, 2057, 6588, 6277, 4722, 1927, 8686, 14966, 1921, 12, 2119, 2132, 13, 2014, 5936, 25166, 4905, 2017, 12, 2119, 3]}, "items": [{"id": "p_103", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_104", "content": "pain [SEP] n seems to depend on direct stimulation of the habitual site of pain, suggesting that the frontotemporal region is of crucial import", "tokenized_content": [2, 3594, 3, 56, 6123, 1942, 4224, 1990, 3083, 4177, 1927, 1920, 23427, 3200, 1927, 3594, 16, 3783, 1988, 1920, 27047, 2057, 6588, 6277, 3031, 1977, 1927, 6608, 2582, 3]}, "items": [{"id": "p_104", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_105", "content": "Clotiazepam [SEP] Clotiazepam-induced acute hepatitis.", "tokenized_content": [2, 15053, 14923, 1976, 3, 15053, 14923, 1976, 17, 2719, 3939, 7977, 18, 3]}, "items": [{"id": "p_105", "content": "clotiazepam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15053, 14923, 1976, 3, 3]}]}
{"query": {"id": "q_106", "content": "hepatitis [SEP] Clotiazepam-induced acute hepatitis.", "tokenized_content": [2, 7977, 3, 15053, 14923, 1976, 17, 2719, 3939, 7977, 18, 3]}, "items": [{"id": "p_106", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_107", "content": "hepatitis [SEP] We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onse", "tokenized_content": [2, 7977, 3, 2038, 3809, 1920, 3087, 1927, 43, 2774, 2746, 3530, 3939, 7977, 1956, 6475, 12457, 7476, 16, 27, 3221, 2256, 1920, 24335, 1021, 3]}, "items": [{"id": "p_107", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_108", "content": "extensive hepatocellular necrosis [SEP] report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a t", "tokenized_content": [2, 6475, 12457, 7476, 3, 3809, 1920, 3087, 1927, 43, 2774, 2746, 3530, 3939, 7977, 1956, 6475, 12457, 7476, 16, 27, 3221, 2256, 1920, 4727, 1927, 4183, 1927, 15053, 14923, 1976, 3]}, "items": [{"id": "p_108", "content": "Massive Hepatic Necrosis [SEP] Extensive and rapid death of parenchymal cells in the LIVER, often due to exposure to toxic materials. It is characterized by a ", "score": 1, "type": null, "tokenized_content": [2, 12944, 6095, 7476, 3, 6475, 1930, 4052, 3539, 1927, 19223, 2094, 1922, 1920, 3568, 16, 3868, 2810, 1942, 3395, 1942, 6161, 4751, 18, 2176, 1977, 4378, 2007, 43, 3]}]}
{"query": {"id": "q_109", "content": "clotiazepam [SEP] ellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was follo", "tokenized_content": [2, 15053, 14923, 1976, 3, 20430, 2168, 7476, 16, 27, 3221, 2256, 1920, 4727, 1927, 4183, 1927, 15053, 14923, 1976, 16, 43, 7566, 19824, 7408, 25360, 10533, 18, 15053, 14923, 1976, 3]}, "items": [{"id": "p_109", "content": "clotiazepam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15053, 14923, 1976, 3, 3]}]}
{"query": {"id": "q_110", "content": "thienodiazepine [SEP] s, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recov", "tokenized_content": [2, 7566, 19824, 7408, 25360, 3, 61, 16, 27, 3221, 2256, 1920, 4727, 1927, 4183, 1927, 15053, 14923, 1976, 16, 43, 7566, 19824, 7408, 25360, 10533, 18, 15053, 14923, 1976, 9594, 3]}, "items": [{"id": "p_110", "content": "thienodiazepine substance [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7566, 19824, 7408, 25360, 7311, 3, 3]}]}
{"query": {"id": "q_111", "content": "Clotiazepam [SEP] of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration ", "tokenized_content": [2, 15053, 14923, 1976, 3, 1927, 4183, 1927, 15053, 14923, 1976, 16, 43, 7566, 19824, 7408, 25360, 10533, 18, 15053, 14923, 1976, 9594, 1982, 3489, 2007, 14393, 5241, 18, 1920, 4183, 3]}, "items": [{"id": "p_111", "content": "clotiazepam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15053, 14923, 1976, 3, 3]}]}
{"query": {"id": "q_112", "content": "benzodiazepines [SEP]  was followed by prompt recovery. The administration of several benzodiazepines, chemically related to clotiazepam, did not interfere with reco", "tokenized_content": [2, 26555, 3, 1982, 3489, 2007, 14393, 5241, 18, 1920, 4183, 1927, 2980, 26555, 16, 13944, 2712, 1942, 15053, 14923, 1976, 16, 2811, 2084, 11827, 1956, 29326, 3]}, "items": [{"id": "p_112", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_113", "content": "hepatotoxicity [SEP]  can induce acute hepatitis and suggests that there is no cross hepatotoxicity between clotiazepam and several benzodiazepines.", "tokenized_content": [2, 24126, 3, 2112, 4769, 3939, 7977, 1930, 4015, 1988, 2276, 1977, 2239, 3567, 24126, 2192, 15053, 14923, 1976, 1930, 2980, 26555, 18, 3]}, "items": [{"id": "p_113", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_114", "content": "hypertension [SEP] Arterial hypertension as a complication of prolonged ketoconazole treatment.", "tokenized_content": [2, 5579, 3, 6624, 5579, 1966, 43, 9388, 1927, 7171, 21471, 12334, 6984, 2311, 18, 3]}, "items": [{"id": "p_114", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_115", "content": "ketoconazole [SEP] Arterial hypertension as a complication of prolonged ketoconazole treatment.", "tokenized_content": [2, 21471, 12334, 6984, 3, 6624, 5579, 1966, 43, 9388, 1927, 7171, 21471, 12334, 6984, 2311, 18, 3]}, "items": [{"id": "p_115", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_116", "content": "Cushing's syndrome [SEP] Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustai", "tokenized_content": [2, 27773, 1941, 11, 61, 4741, 3, 2288, 1927, 2607, 2132, 1956, 27773, 1941, 11, 61, 4741, 2868, 1990, 43, 2815, 17, 2576, 4859, 1956, 21471, 12334, 6984, 3530, 9105, 5504, 3]}, "items": [{"id": "p_116", "content": "Cushing Syndrome [SEP] A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous ", "score": 1, "type": null, "tokenized_content": [2, 27773, 1941, 4741, 3, 43, 2625, 4189, 2007, 7171, 3395, 1942, 5799, 2428, 1927, 9806, 12, 28184, 13, 2014, 2303, 18004, 2037, 5355, 3]}]}
{"query": {"id": "q_117", "content": "ketoconazole [SEP] ients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained hypertension. In both cases normal plasma a", "tokenized_content": [2, 21471, 12334, 6984, 3, 10116, 4905, 1036, 1956, 27773, 1941, 11, 61, 4741, 2868, 1990, 43, 2815, 17, 2576, 4859, 1956, 21471, 12334, 6984, 3530, 7637, 5579, 18, 1922, 2321, 3]}, "items": [{"id": "p_117", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_118", "content": "hypertension [SEP] ated on a long-term basis with ketoconazole developed sustained hypertension. In both cases normal plasma and urinary free cortisol levels h", "tokenized_content": [2, 5579, 3, 30280, 1007, 1990, 43, 2815, 17, 2576, 4859, 1956, 21471, 12334, 6984, 3530, 7637, 5579, 18, 1922, 2321, 2919, 2791, 3582, 1930, 7075, 3294, 9806, 2428, 50, 3]}, "items": [{"id": "p_118", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_119", "content": "cortisol [SEP] ined hypertension. In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet co", "tokenized_content": [2, 9806, 3, 11116, 1007, 5579, 18, 1922, 2321, 2919, 2791, 3582, 1930, 7075, 3294, 9806, 2428, 2430, 2252, 5032, 2894, 21471, 12334, 6984, 3181, 16, 4898, 2081, 3]}, "items": [{"id": "p_119", "content": "Hydrocortisone [SEP] The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, ", "score": 1, "type": null, "tokenized_content": [2, 28184, 3, 1920, 2730, 14469, 8366, 2007, 1920, 10651, 4997, 18, 2496, 6830, 18471, 1977, 2251, 16, 3108, 1966, 1925, 4107, 2014, 12259, 1954, 16, 3]}]}
{"query": {"id": "q_120", "content": "deoxycorticosterone [SEP] eks (patient 2) after treatment. In patient 1, plasma levels of deoxycorticosterone and 11-deoxycortisol were elevated. In patient 2, in addition t", "tokenized_content": [2, 16333, 4879, 7446, 5670, 2156, 6506, 2912, 3, 20529, 1036, 12, 2774, 22, 13, 2256, 2311, 18, 1922, 2774, 21, 16, 3582, 2428, 1927, 16333, 4879, 7446, 5670, 2156, 6506, 3]}, "items": [{"id": "p_120", "content": "Desoxycorticosterone [SEP] A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE\n    ", "score": 1, "type": null, "tokenized_content": [2, 2270, 7221, 4879, 7446, 5670, 2156, 6506, 2912, 3, 43, 9507, 9483, 1988, 1977, 1920, 2513, 17, 16333, 10533, 1927, 18136, 1930, 1920, 2900, 17, 8275, 10533, 1927, 11528, 3]}]}
{"query": {"id": "q_121", "content": "11-deoxycortisol [SEP] eatment. In patient 1, plasma levels of deoxycorticosterone and 11-deoxycortisol were elevated. In patient 2, in addition to an increase in both", "tokenized_content": [2, 2513, 17, 16333, 4879, 7446, 23854, 1024, 3, 13619, 2017, 18, 1922, 2774, 21, 16, 3582, 2428, 1927, 16333, 4879, 7446, 5670, 2156, 6506, 2912, 1930, 2513, 17, 16333, 4879, 3]}, "items": [{"id": "p_121", "content": "Cortodoxone [SEP] 17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18964, 1986, 21671, 3, 2752, 16, 2900, 17, 20684, 4060, 3223, 17, 24, 17, 2066, 1021, 17, 23, 16, 2036, 17, 23652, 2912, 18, 43, 2752, 17, 8275, 4879, 7446, 5670, 2156, 6506, 1960, 1956, 14469, 1930, 2246, 17, 3769, 4209, 18, 3]}]}
{"query": {"id": "q_122", "content": "aldosterone [SEP] in both deoxycorticosterone and 11-deoxycortisol levels, plasma aldosterone values were raised, with a concomitant suppression of renin lev", "tokenized_content": [2, 16944, 3, 1922, 2321, 16333, 4879, 7446, 5670, 2156, 6506, 2912, 1930, 2513, 17, 16333, 4879, 7446, 23854, 1024, 2428, 16, 3582, 16944, 2851, 1985, 8930, 16, 1956, 43, 8537, 3]}, "items": [{"id": "p_122", "content": "Aldosterone [SEP] A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodiu", "score": 1, "type": null, "tokenized_content": [2, 16944, 3, 43, 6365, 8366, 2007, 1920, 10651, 4997, 1988, 7014, 15428, 1930, 3224, 6766, 2007, 3605, 1920, 4604, 7521, 1927, 4546, 1033, 1032, 3]}]}
{"query": {"id": "q_123", "content": "angiotensin [SEP] Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficie", "tokenized_content": [2, 10814, 3, 2564, 1927, 1925, 4106, 1927, 10814, 15025, 4113, 12, 7502, 24863, 13, 1990, 5352, 1930, 4604, 7697, 6167, 1021, 3]}, "items": [{"id": "p_123", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_124", "content": "Captopril [SEP] Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coag", "tokenized_content": [2, 7502, 24863, 3, 2564, 1927, 1925, 4106, 1927, 10814, 15025, 4113, 12, 7502, 24863, 13, 1990, 5352, 1930, 4604, 14566, 2810, 1942, 19871, 10027, 1029, 3]}, "items": [{"id": "p_124", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_125", "content": "renal insufficiency [SEP] r of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat.", "tokenized_content": [2, 4604, 14566, 3, 60, 1927, 10814, 15025, 4113, 12, 7502, 24863, 13, 1990, 5352, 1930, 4604, 14566, 2810, 1942, 19871, 12441, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_125", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_126", "content": "intravascular coagulation [SEP]  enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat.", "tokenized_content": [2, 19871, 12441, 3, 4113, 12, 7502, 24863, 13, 1990, 5352, 1930, 4604, 14566, 2810, 1942, 19871, 12441, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_126", "content": "Disseminated Intravascular Coagulation [SEP] A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The ", "score": 1, "type": null, "tokenized_content": [2, 17593, 19871, 12441, 3, 43, 4770, 4378, 2007, 9823, 6952, 11056, 17576, 1031, 10054, 14657, 1920, 3335, 9255, 7538, 43, 5510, 21039, 2585, 18, 1920, 3]}]}
{"query": {"id": "q_127", "content": "intravascular coagulation [SEP] Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tra", "tokenized_content": [2, 19871, 12441, 3, 4408, 1927, 19871, 12441, 1930, 3523, 1927, 9450, 6892, 2007, 4107, 1927, 12388, 1930, 3390, 3]}, "items": [{"id": "p_127", "content": "Disseminated Intravascular Coagulation [SEP] A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The ", "score": 1, "type": null, "tokenized_content": [2, 17593, 19871, 12441, 3, 43, 4770, 4378, 2007, 9823, 6952, 11056, 17576, 1031, 10054, 14657, 1920, 3335, 9255, 7538, 43, 5510, 21039, 2585, 18, 1920, 3]}]}
{"query": {"id": "q_128", "content": "tranexamic acid [SEP] ion and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficien", "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 4755, 1930, 3523, 1927, 9450, 6892, 2007, 4107, 1927, 12388, 1930, 29808, 2783, 13514, 2687, 12, 27017, 1019, 13, 1922, 1920, 3067, 10006, 7164, 1942, 3]}, "items": [{"id": "p_128", "content": "Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 12244, 3693, 21092, 4274, 30077, 2251, 1922, 4010, 10489, 18, 3]}]}
{"query": {"id": "q_129", "content": "AMCA [SEP] n of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency res", "tokenized_content": [2, 27017, 1019, 3, 56, 1927, 9450, 6892, 2007, 4107, 1927, 12388, 1930, 29808, 2783, 13514, 2687, 12, 27017, 1019, 13, 1922, 1920, 3067, 10006, 7164, 1942, 5352, 1930, 4604, 14566, 3]}, "items": [{"id": "p_129", "content": "Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 12244, 3693, 21092, 4274, 30077, 2251, 1922, 4010, 10489, 18, 3]}]}
{"query": {"id": "q_130", "content": "renal insufficiency [SEP] d tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency resembling that occurring after trauma or sepsis in man. Inject", "tokenized_content": [2, 4604, 14566, 3, 46, 29808, 2783, 13514, 2687, 12, 27017, 1019, 13, 1922, 1920, 3067, 10006, 7164, 1942, 5352, 1930, 4604, 14566, 18994, 1988, 6966, 2256, 7176, 2014, 9019, 1922, 3]}, "items": [{"id": "p_130", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_131", "content": "trauma [SEP] lmonary and renal insufficiency resembling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibito", "tokenized_content": [2, 7176, 3, 7735, 12502, 6907, 1930, 4604, 14566, 18994, 1988, 6966, 2256, 7176, 2014, 9019, 1922, 2323, 18, 4107, 1927, 7502, 24863, 12, 21, 2786, 19, 3621, 13, 16, 1925, 3]}, "items": [{"id": "p_131", "content": "Wounds and Injuries [SEP] Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural con", "score": 1, "type": null, "tokenized_content": [2, 14107, 1930, 8209, 3, 4293, 2552, 5847, 1919, 1990, 1920, 3362, 1966, 1920, 3083, 2014, 6354, 3211, 1927, 1925, 5771, 5495, 16, 1956, 2014, 2979, 7561, 1927, 4346, 1962, 3]}]}
{"query": {"id": "q_132", "content": "sepsis [SEP] d renal insufficiency resembling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angio", "tokenized_content": [2, 9019, 3, 46, 4604, 14566, 18994, 1988, 6966, 2256, 7176, 2014, 9019, 1922, 2323, 18, 4107, 1927, 7502, 24863, 12, 21, 2786, 19, 3621, 13, 16, 1925, 4106, 1927, 29220, 3]}, "items": [{"id": "p_132", "content": "Sepsis [SEP] Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dys", "score": 1, "type": null, "tokenized_content": [2, 9019, 3, 5510, 3769, 2644, 4741, 1956, 43, 9253, 2014, 9407, 7465, 10383, 18, 2469, 9019, 1977, 2458, 1956, 3090, 3890, 3]}]}
{"query": {"id": "q_133", "content": "Captopril [SEP] ling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (ACE),", "tokenized_content": [2, 7502, 24863, 3, 12296, 1988, 6966, 2256, 7176, 2014, 9019, 1922, 2323, 18, 4107, 1927, 7502, 24863, 12, 21, 2786, 19, 3621, 13, 16, 1925, 4106, 1927, 10814, 15025, 4113, 3]}, "items": [{"id": "p_133", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_134", "content": "angiotensin [SEP] epsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (ACE), reduced both pulmonary and renal insuf", "tokenized_content": [2, 10814, 3, 9178, 1937, 1922, 2323, 18, 4107, 1927, 7502, 24863, 12, 21, 2786, 19, 3621, 13, 16, 1925, 4106, 1927, 10814, 15025, 4113, 12, 8298, 13, 16, 3028, 2321, 3]}, "items": [{"id": "p_134", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_135", "content": "Renal damage [SEP]  that Captopril did not influence the extravasation of protein. Renal damage as reflected by an increase in serum urea and in kidney weight ", "tokenized_content": [2, 4604, 4293, 3, 1988, 7502, 24863, 2811, 2084, 4039, 1920, 23535, 1927, 2213, 18, 4604, 4293, 1966, 8830, 2007, 1925, 2760, 1922, 3256, 10505, 1930, 1922, 5245, 3388, 3]}, "items": [{"id": "p_135", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_136", "content": "urea [SEP] n of protein. Renal damage as reflected by an increase in serum urea and in kidney weight was prevented by Captopril. The amount of ", "tokenized_content": [2, 10505, 3, 56, 1927, 2213, 18, 4604, 4293, 1966, 8830, 2007, 1925, 2760, 1922, 3256, 10505, 1930, 1922, 5245, 3388, 1982, 8715, 2007, 7502, 24863, 18, 1920, 4351, 1927, 3]}, "items": [{"id": "p_136", "content": "Urea [SEP] A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of prote", "score": 1, "type": null, "tokenized_content": [2, 10505, 3, 43, 3547, 5333, 1922, 1920, 3568, 2037, 14880, 4152, 2007, 1920, 30097, 8547, 1943, 1927, 3835, 4576, 18, 2176, 1977, 1920, 7944, 2482, 4863, 1927, 2174, 3]}]}
{"query": {"id": "q_137", "content": "Angiotension II [SEP] odilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in br", "tokenized_content": [2, 10747, 3212, 2890, 3, 4426, 19167, 27708, 2495, 2810, 1942, 43, 3378, 1922, 1920, 7396, 2237, 1927, 10747, 3212, 2890, 1930, 1925, 2760, 1922, 4876, 23689, 1921, 12, 4067, 1942, 3]}, "items": [{"id": "p_137", "content": "Angiotensin II [SEP] An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino aci", "score": 1, "type": null, "tokenized_content": [2, 10814, 2890, 3, 1925, 5843, 24010, 1988, 1977, 43, 6828, 2308, 22001, 28404, 2684, 18, 2176, 1977, 4152, 2037, 10814, 51, 2256, 1920, 6025, 1927, 2288, 3835, 2000, 1033, 3]}]}
{"query": {"id": "q_138", "content": "prostacyclin [SEP]  in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in bradykinin). Captopril may, by the", "tokenized_content": [2, 4876, 23689, 1921, 3, 1922, 1920, 7396, 2237, 1927, 10747, 3212, 2890, 1930, 1925, 2760, 1922, 4876, 23689, 1921, 12, 4067, 1942, 1925, 2760, 1922, 25448, 13, 18, 7502, 24863, 3]}, "items": [{"id": "p_138", "content": "Epoprostenol [SEP] A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTA", "score": 1, "type": null, "tokenized_content": [2, 15751, 2216, 24690, 1945, 3, 43, 15900, 1988, 1977, 43, 9974, 28194, 1930, 7042, 7163, 7883, 18, 2176, 1977, 7067, 4958, 23958, 2037, 4876, 1019, 3]}]}
{"query": {"id": "q_139", "content": "bradykinin [SEP] II and an increase in prostacyclin (secondary to an increase in bradykinin). Captopril may, by the same mechanism, reduce the increase in ", "tokenized_content": [2, 25448, 3, 2890, 1930, 1925, 2760, 1922, 4876, 23689, 1921, 12, 4067, 1942, 1925, 2760, 1922, 25448, 13, 18, 7502, 24863, 2278, 16, 2007, 1920, 2841, 2856, 16, 4412, 1920, 3]}, "items": [{"id": "p_139", "content": "Bradykinin [SEP] A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of ", "score": 1, "type": null, "tokenized_content": [2, 25448, 3, 43, 2447, 24010, 16716, 1988, 1977, 23958, 4152, 2037, 25846, 7650, 1922, 1920, 2877, 2597, 2176, 1977, 43, 6828, 2308, 3662, 17, 11698, 5899, 1927, 3]}]}
{"query": {"id": "q_140", "content": "kidney damage [SEP] ith the result that less fibrin will be deposited and thus less kidney damage will be produced.", "tokenized_content": [2, 5245, 4293, 3, 24737, 1920, 3211, 1988, 2941, 9450, 2832, 1998, 10199, 1930, 2842, 2941, 5245, 4293, 2832, 1998, 4152, 18, 3]}, "items": [{"id": "p_140", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_141", "content": "labetalol [SEP] A randomized comparison of labetalol and nitroprusside for induced hypotension.", "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 5542, 3723, 1927, 2857, 3949, 1945, 1930, 8686, 2047, 3468, 2261, 1958, 2719, 16453, 18, 3]}, "items": [{"id": "p_141", "content": "Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.\n ", "score": 1, "type": null, "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 20734, 10406, 10533, 1988, 1977, 43, 2447, 17, 21129, 4127, 25419, 2185, 14580, 1927, 4666, 17, 13672, 4086, 1930, 4595, 17, 21, 13672, 4086, 18, 3]}]}
{"query": {"id": "q_142", "content": "nitroprusside [SEP] A randomized comparison of labetalol and nitroprusside for induced hypotension.", "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 5542, 3723, 1927, 2857, 3949, 1945, 1930, 8686, 2047, 3468, 2261, 1958, 2719, 16453, 18, 3]}, "items": [{"id": "p_142", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_143", "content": "hypotension [SEP] andomized comparison of labetalol and nitroprusside for induced hypotension.", "tokenized_content": [2, 16453, 3, 1930, 1947, 2301, 3723, 1927, 2857, 3949, 1945, 1930, 8686, 2047, 3468, 2261, 1958, 2719, 16453, 18, 3]}, "items": [{"id": "p_143", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_144", "content": "labetalol [SEP] In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were ", "tokenized_content": [2, 2857, 3949, 1945, 3, 1922, 43, 5542, 2161, 16, 2857, 3949, 1945, 17, 2719, 16453, 1930, 8686, 2047, 3468, 2261, 17, 2719, 16453, 1985, 3]}, "items": [{"id": "p_144", "content": "Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.\n ", "score": 1, "type": null, "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 20734, 10406, 10533, 1988, 1977, 43, 2447, 17, 21129, 4127, 25419, 2185, 14580, 1927, 4666, 17, 13672, 4086, 1930, 4595, 17, 21, 13672, 4086, 18, 3]}]}
{"query": {"id": "q_145", "content": "hypotension [SEP] In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patie", "tokenized_content": [2, 16453, 3, 1922, 43, 5542, 2161, 16, 2857, 3949, 1945, 17, 2719, 16453, 1930, 8686, 2047, 3468, 2261, 17, 2719, 16453, 1985, 2452, 1922, 2036, 2091, 1021, 3]}, "items": [{"id": "p_145", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_146", "content": "nitroprusside [SEP] In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each gr", "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 1922, 43, 5542, 2161, 16, 2857, 3949, 1945, 17, 2719, 16453, 1930, 8686, 2047, 3468, 2261, 17, 2719, 16453, 1985, 2452, 1922, 2036, 2132, 12, 3]}, "items": [{"id": "p_146", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_147", "content": "reductions in mean arterial blood pressure [SEP] ed to an identical anesthetic protocol and similar drug-induced reductions in mean arterial blood pressure (BP) (50 to 55 mmHg). Nitroprusside infusion was associated wit", "tokenized_content": [2, 9350, 1922, 2667, 6624, 2877, 3772, 3, 3347, 1942, 1925, 6119, 16111, 4478, 1930, 2551, 2838, 17, 2719, 9350, 1922, 2667, 6624, 2877, 3772, 12, 4149, 13, 12, 2761, 1942, 3]}, "items": [{"id": "p_147", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_148", "content": "increase in heart rate and cardiac output [SEP] e infusion was associated with a significant (p less than 0.05) increase in heart rate and cardiac output; rebound hypertension was observed in three patients after disc", "tokenized_content": [2, 2760, 1922, 4003, 2769, 1930, 4435, 6647, 3, 47, 7386, 1982, 2458, 1956, 43, 2228, 12, 58, 2941, 2254, 20, 18, 2914, 13, 2760, 1922, 4003, 2769, 1930, 4435, 6647, 3]}, "items": [{"id": "p_148", "content": "Cardiac Output, High [SEP] A state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. Th", "score": 1, "type": null, "tokenized_content": [2, 4435, 6647, 16, 2149, 3, 43, 3360, 1927, 4664, 4435, 6647, 2810, 1942, 2961, 1927, 3108, 2502, 12173, 9749, 2014, 3028, 4435, 4612, 6647, 18, 1913, 3]}]}
{"query": {"id": "q_149", "content": "hypertension [SEP] s than 0.05) increase in heart rate and cardiac output; rebound hypertension was observed in three patients after discontinuation of nitropr", "tokenized_content": [2, 5579, 3, 61, 2254, 20, 18, 2914, 13, 2760, 1922, 4003, 2769, 1930, 4435, 6647, 31, 22845, 5579, 1982, 2528, 1922, 2559, 2132, 2256, 14775, 1927, 8686, 2047, 3]}, "items": [{"id": "p_149", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_150", "content": "Labetalol [SEP] erved in three patients after discontinuation of nitroprusside. Labetalol administration was not associated with any of these findings. A", "tokenized_content": [2, 2857, 3949, 1945, 3, 2668, 2173, 1922, 2559, 2132, 2256, 14775, 1927, 8686, 2047, 3468, 2261, 18, 2857, 3949, 1945, 4183, 1982, 2084, 2458, 1956, 2967, 1927, 2144, 3056, 18, 3]}, "items": [{"id": "p_150", "content": "Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.\n ", "score": 1, "type": null, "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 20734, 10406, 10533, 1988, 1977, 43, 2447, 17, 21129, 4127, 25419, 2185, 14580, 1927, 4666, 17, 13672, 4086, 1930, 4595, 17, 21, 13672, 4086, 18, 3]}]}
{"query": {"id": "q_151", "content": "PO2 [SEP] tration was not associated with any of these findings. Arterial PO2 decreased in both groups. It was concluded that labetalol offer", "tokenized_content": [2, 24139, 3, 3390, 1929, 1982, 2084, 2458, 1956, 2967, 1927, 2144, 3056, 18, 6624, 24139, 3261, 1922, 2321, 2671, 18, 2176, 1982, 7903, 1988, 2857, 3949, 1945, 6260, 3]}, "items": [{"id": "p_151", "content": "PO-2 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2510, 17, 22, 3, 3]}]}
{"query": {"id": "q_152", "content": "carbamazepine [SEP] Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma ", "tokenized_content": [2, 30315, 3, 3724, 30315, 2311, 1922, 1920, 3067, 30, 4348, 16, 5532, 16, 1930, 2495, 1990, 3582, 3]}, "items": [{"id": "p_152", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_153", "content": "toxicity [SEP] Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations.", "tokenized_content": [2, 5532, 3, 3724, 30315, 2311, 1922, 1920, 3067, 30, 4348, 16, 5532, 16, 1930, 2495, 1990, 3582, 1930, 2960, 13761, 3295, 18, 3]}, "items": [{"id": "p_153", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_154", "content": "folate [SEP] in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations.", "tokenized_content": [2, 13761, 3, 1922, 1920, 3067, 30, 4348, 16, 5532, 16, 1930, 2495, 1990, 3582, 1930, 2960, 13761, 3295, 18, 3]}, "items": [{"id": "p_154", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_155", "content": "Folate [SEP] Folate depletion has often been a problem in chronic antiepileptic dru", "tokenized_content": [2, 13761, 3, 13761, 6882, 2258, 3868, 2252, 43, 4915, 1922, 3724, 29132, 2324, 1032, 3]}, "items": [{"id": "p_155", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_156", "content": "Carbamazepine [SEP] ten been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinica", "tokenized_content": [2, 30315, 3, 5656, 2252, 43, 4915, 1922, 3724, 29132, 2838, 12, 18572, 13, 3181, 18, 30315, 12, 5529, 1011, 13, 16, 43, 5384, 2251, 18572, 16, 2258, 2252, 6835, 1922, 3]}, "items": [{"id": "p_156", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_157", "content": "CBZ [SEP] lem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical stu", "tokenized_content": [2, 5529, 1011, 3, 15551, 1922, 3724, 29132, 2838, 12, 18572, 13, 3181, 18, 30315, 12, 5529, 1011, 13, 16, 43, 5384, 2251, 18572, 16, 2258, 2252, 6835, 1922, 2673, 2535, 3]}, "items": [{"id": "p_157", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_158", "content": "folate [SEP] as developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat. In the course of developing this mod", "tokenized_content": [2, 13761, 3, 1966, 3530, 1942, 5020, 1920, 2564, 1927, 3724, 5529, 1011, 2311, 1990, 13761, 3295, 1922, 1920, 3067, 18, 1922, 1920, 4914, 1927, 5130, 2052, 2157, 3]}, "items": [{"id": "p_158", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_159", "content": "propylene glycol [SEP]  rat. In the course of developing this model, a common vehicle, propylene glycol, by itself in high doses, was found to exhibit protective prope", "tokenized_content": [2, 20299, 2880, 14193, 3, 3067, 18, 1922, 1920, 4914, 1927, 5130, 2052, 2322, 16, 43, 3059, 6463, 16, 20299, 2880, 14193, 16, 2007, 6999, 1922, 2149, 5312, 16, 1982, 2435, 3]}, "items": [{"id": "p_159", "content": "Propylene Glycol [SEP] A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20299, 2880, 14193, 3, 43, 4021, 16, 29500, 16, 24855, 6805, 7596, 1930, 4333, 12044, 2251, 1922, 11106, 9815, 18, 3]}]}
{"query": {"id": "q_160", "content": "seizures [SEP] ses, was found to exhibit protective properties against induced seizures and inhibited weight gain. Seizures induced by hexafluorodiethy", "tokenized_content": [2, 10060, 3, 9924, 16, 1982, 2435, 1942, 5987, 6337, 3879, 3316, 2719, 10060, 1930, 5069, 3388, 5938, 18, 10060, 2719, 2007, 7142, 20074, 15799, 3184, 1012, 3]}, "items": [{"id": "p_160", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_161", "content": "weight gain [SEP] it protective properties against induced seizures and inhibited weight gain. Seizures induced by hexafluorodiethyl ether (HFDE) were also f", "tokenized_content": [2, 3388, 5938, 3, 2176, 6337, 3879, 3316, 2719, 10060, 1930, 5069, 3388, 5938, 18, 10060, 2719, 2007, 7142, 20074, 15799, 5188, 14121, 12, 11922, 1021, 13, 1985, 2222, 48, 3]}, "items": [{"id": "p_161", "content": "Weight Gain [SEP] Increase in BODY WEIGHT over existing weight.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3388, 5938, 3, 2760, 1922, 3362, 3388, 2338, 6124, 3388, 18, 3]}]}
{"query": {"id": "q_162", "content": "Seizures [SEP]  properties against induced seizures and inhibited weight gain. Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be", "tokenized_content": [2, 10060, 3, 3879, 3316, 2719, 10060, 1930, 5069, 3388, 5938, 18, 10060, 2719, 2007, 7142, 20074, 15799, 5188, 14121, 12, 11922, 1021, 13, 1985, 2222, 2435, 1942, 1998, 3]}, "items": [{"id": "p_162", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_163", "content": "hexafluorodiethyl ether [SEP] induced seizures and inhibited weight gain. Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protec", "tokenized_content": [2, 7142, 20074, 15799, 5188, 14121, 3, 2719, 10060, 1930, 5069, 3388, 5938, 18, 10060, 2719, 2007, 7142, 20074, 15799, 5188, 14121, 12, 11922, 1021, 13, 1985, 2222, 2435, 1942, 1998, 3]}, "items": [{"id": "p_163", "content": "Flurothyl [SEP] A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock", "score": 1, "type": null, "tokenized_content": [2, 2848, 6843, 30338, 1024, 3, 43, 4772, 6325, 2031, 5985, 2251, 1922, 3599, 3555, 18, 2176, 1982, 22397, 2251, 1942, 4769, 4772, 19389, 1966, 43, 5012, 1942, 17975, 10647, 12940, 3]}]}
{"query": {"id": "q_164", "content": "HFDE [SEP] bited weight gain. Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protection b", "tokenized_content": [2, 11922, 1021, 3, 21095, 1007, 3388, 5938, 18, 10060, 2719, 2007, 7142, 20074, 15799, 5188, 14121, 12, 11922, 1021, 13, 1985, 2222, 2435, 1942, 1998, 43, 2253, 4532, 2931, 1927, 3]}, "items": [{"id": "p_164", "content": "Flurothyl [SEP] A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock", "score": 1, "type": null, "tokenized_content": [2, 2848, 6843, 30338, 1024, 3, 43, 4772, 6325, 2031, 5985, 2251, 1922, 3599, 3555, 18, 2176, 1982, 22397, 2251, 1942, 4769, 4772, 19389, 1966, 43, 5012, 1942, 17975, 10647, 12940, 3]}]}
{"query": {"id": "q_165", "content": "sodium [SEP] In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed ", "tokenized_content": [2, 5227, 3, 1922, 3798, 11993, 16, 7800, 7894, 16, 5514, 1990, 43, 2791, 5227, 5240, 1927, 22, 1942, 24, 25509, 19, 3621, 19, 3007, 16, 11739, 2455, 1982, 3683, 3]}, "items": [{"id": "p_165", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_166", "content": "norepinephrine [SEP] g/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-", "tokenized_content": [2, 16436, 3, 49, 19, 3007, 16, 11739, 2455, 1982, 3683, 1966, 1920, 4012, 2769, 1927, 16436, 1930, 19280, 2409, 2461, 17, 8623, 51, 18, 64, 18, 17656, 1927, 2616, 4595, 3]}, "items": [{"id": "p_166", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_167", "content": "epinephrine [SEP] ay, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-", "tokenized_content": [2, 19280, 3, 15874, 16, 11739, 2455, 1982, 3683, 1966, 1920, 4012, 2769, 1927, 16436, 1930, 19280, 2409, 2461, 17, 8623, 51, 18, 64, 18, 17656, 1927, 2616, 4595, 17, 3]}, "items": [{"id": "p_167", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_168", "content": "tachycardia [SEP] n 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no tachycardia and no augmentation of the norepinephrine release rate (up to 0", "tokenized_content": [2, 17397, 3, 56, 20, 18, 3287, 13, 16, 2014, 5637, 15, 19, 17, 26, 9, 12, 58, 2941, 2254, 20, 18, 3472, 13, 16, 2763, 16, 2308, 2239, 17397, 1930, 3]}, "items": [{"id": "p_168", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_169", "content": "hypotension [SEP] ogram/kg/min) were observed, which is in contrast to comparable hypotension induced by hydralazine or nitroglycerin. The release rate of ep", "tokenized_content": [2, 16453, 3, 17395, 29085, 19, 3621, 19, 2360, 13, 1985, 2528, 16, 2154, 1977, 1922, 3320, 1942, 5596, 16453, 2719, 2007, 22420, 5148, 22030, 2912, 2014, 8686, 14966, 1921, 18, 3]}, "items": [{"id": "p_169", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_170", "content": "hydralazine [SEP] rved, which is in contrast to comparable hypotension induced by hydralazine or nitroglycerin. The release rate of epinephrine (control, 6.7", "tokenized_content": [2, 22420, 5148, 22030, 2912, 3, 8309, 1919, 16, 2154, 1977, 1922, 3320, 1942, 5596, 16453, 2719, 2007, 22420, 5148, 22030, 2912, 2014, 8686, 14966, 1921, 18, 1920, 4012, 2769, 1927, 3]}, "items": [{"id": "p_170", "content": "Hydralazine [SEP] A direct-acting vasodilator that is used as an antihypertensive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22420, 5148, 22030, 2912, 3, 43, 3083, 17, 8290, 28194, 1988, 1977, 2251, 1966, 1925, 16439, 5899, 18, 3]}]}
{"query": {"id": "q_171", "content": "nitroglycerin [SEP] in contrast to comparable hypotension induced by hydralazine or nitroglycerin. The release rate of epinephrine (control, 6.7 +/- 0.6 ng/kg/mi", "tokenized_content": [2, 8686, 14966, 1921, 3, 1922, 3320, 1942, 5596, 16453, 2719, 2007, 22420, 5148, 22030, 2912, 2014, 8686, 14966, 1921, 18, 1920, 4012, 2769, 1927, 19280, 12, 2285, 16, 26, 18, 3]}, "items": [{"id": "p_171", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_172", "content": "Death [SEP] Death from chemotherapy in gestational trophoblastic disease.", "tokenized_content": [2, 3539, 3, 3539, 2037, 5318, 1922, 10000, 23089, 1935, 2573, 18, 3]}, "items": [{"id": "p_172", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_173", "content": "gestational trophoblastic disease [SEP] Death from chemotherapy in gestational trophoblastic disease.", "tokenized_content": [2, 10000, 23089, 1935, 2573, 3, 3539, 2037, 5318, 1922, 10000, 23089, 1935, 2573, 18, 3]}, "items": [{"id": "p_173", "content": "Gestational Trophoblastic Disease [SEP] A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and marke", "score": 1, "type": null, "tokenized_content": [2, 10000, 23089, 1935, 2573, 3, 43, 2210, 1927, 3902, 11894, 2037, 5284, 1988, 2032, 5384, 2458, 1956, 13095, 1927, 23089, 1036, 12, 23089, 13, 1930, 2937, 1021, 3]}]}
{"query": {"id": "q_174", "content": "choriocarcinoma [SEP] erally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as bei", "tokenized_content": [2, 25952, 21615, 3, 14821, 11560, 1012, 8131, 2311, 1927, 2132, 1956, 43, 2149, 17, 2565, 3587, 1927, 25952, 21615, 18, 2454, 1990, 2052, 9733, 43, 3225, 17, 2476, 4156, 10440, 3]}, "items": [{"id": "p_174", "content": "Choriocarcinoma [SEP] A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI b", "score": 1, "type": null, "tokenized_content": [2, 25952, 21615, 3, 43, 6558, 6476, 2386, 1927, 23089, 1935, 3861, 18, 7945, 1920, 2993, 8525, 6154, 22372, 16, 25952, 21615, 5461, 2239, 28776, 29312, 44, 3]}]}
{"query": {"id": "q_175", "content": "Etoposide [SEP] ultiple cytotoxic drugs. The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cispla", "tokenized_content": [2, 18892, 3, 3570, 14245, 1952, 8377, 4195, 18, 1920, 3137, 2838, 26374, 6994, 1927, 30, 18892, 2641, 18, 18317, 16, 18031, 16, 17135, 16, 4033, 7928, 17, 46, 16, 1930, 3]}, "items": [{"id": "p_175", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_176", "content": "Methotrexate [SEP] drugs. The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day", "tokenized_content": [2, 18031, 3, 4195, 18, 1920, 3137, 2838, 26374, 6994, 1927, 30, 18892, 2641, 18, 18317, 16, 18031, 16, 17135, 16, 4033, 7928, 17, 46, 16, 1930, 9284, 18, 1990, 1920, 3]}, "items": [{"id": "p_176", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_177", "content": "Cyclophosphamide [SEP] tiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, ", "tokenized_content": [2, 17135, 3, 7933, 1952, 2838, 26374, 6994, 1927, 30, 18892, 2641, 18, 18317, 16, 18031, 16, 17135, 16, 4033, 7928, 17, 46, 16, 1930, 9284, 18, 1990, 1920, 2561, 3007, 3]}, "items": [{"id": "p_177", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_178", "content": "Actomycin-D [SEP] consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high", "tokenized_content": [2, 4033, 7928, 17, 46, 3, 6994, 1927, 30, 18892, 2641, 18, 18317, 16, 18031, 16, 17135, 16, 4033, 7928, 17, 46, 16, 1930, 9284, 18, 1990, 1920, 2561, 3007, 1927, 3]}, "items": [{"id": "p_178", "content": "Dactinomycin [SEP] A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to ", "score": 1, "type": null, "tokenized_content": [2, 22322, 2268, 7928, 3, 43, 3547, 7179, 1927, 43, 2288, 9821, 5320, 8765, 1942, 43, 3037, 2325, 10119, 1988, 1977, 3595, 2037, 22874, 19995, 3199, 1957, 18, 2176, 6876, 1942, 3]}]}
{"query": {"id": "q_179", "content": "Cisplatin [SEP] poside 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high doses of Metho", "tokenized_content": [2, 9284, 3, 2159, 2261, 2641, 18, 18317, 16, 18031, 16, 17135, 16, 4033, 7928, 17, 46, 16, 1930, 9284, 18, 1990, 1920, 2561, 3007, 1927, 1920, 11660, 16, 5086, 2149, 3]}, "items": [{"id": "p_179", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_180", "content": "pulmonary obstruction [SEP] apy the patient died with a clinical picture resembling massive pulmonary obstruction due to choriocarcinomic tissue plugs, probably originating from", "tokenized_content": [2, 5352, 10849, 3, 2100, 1012, 1920, 2774, 8545, 1956, 43, 2535, 10213, 18994, 12944, 5352, 10849, 2810, 1942, 25952, 7907, 3264, 2960, 15998, 1036, 16, 6226, 14391, 2037, 3]}, "items": [{"id": "p_180", "content": "Pulmonary Embolism [SEP] Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5352, 19287, 3, 7472, 1927, 1920, 5352, 5511, 2014, 2340, 1927, 2496, 11208, 2007, 1925, 12494, 1957, 18, 3]}]}
{"query": {"id": "q_181", "content": "tumor [SEP]  uterus. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, ", "tokenized_content": [2, 2798, 3, 16297, 18, 3337, 1927, 2144, 15998, 1036, 1982, 6226, 2810, 1942, 6475, 2798, 7476, 2019, 1920, 2237, 1927, 1920, 12430, 1927, 1920, 3044, 10885, 14785, 16, 3]}, "items": [{"id": "p_181", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_182", "content": "necrosis [SEP] s. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which res", "tokenized_content": [2, 7476, 3, 61, 18, 3337, 1927, 2144, 15998, 1036, 1982, 6226, 2810, 1942, 6475, 2798, 7476, 2019, 1920, 2237, 1927, 1920, 12430, 1927, 1920, 3044, 10885, 14785, 16, 2154, 1995, 3]}, "items": [{"id": "p_182", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_183", "content": "embolism [SEP] etween the start of chemotherapy and the acute onset of massive embolism other explanations, such as spontaneous necrosis, must be consi", "tokenized_content": [2, 19287, 3, 2140, 2189, 1920, 6413, 1927, 5318, 1930, 1920, 3939, 4727, 1927, 12944, 19287, 2303, 14370, 16, 2427, 1966, 6242, 7476, 16, 4902, 1998, 2134, 1033, 3]}, "items": [{"id": "p_183", "content": "Embolism [SEP] Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19287, 3, 7472, 1927, 43, 2877, 8072, 2007, 1925, 12494, 1957, 2154, 2112, 1998, 43, 2877, 15053, 2014, 2303, 3075, 2348, 5145, 3485, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_184", "content": "pelvic tumor [SEP] s necrosis, must be considered less likely. Patients with large pelvic tumor loads are, according to existing classifications, at high risk ", "tokenized_content": [2, 10953, 2798, 3, 61, 7476, 16, 4902, 1998, 3311, 2941, 3205, 18, 2132, 1956, 3103, 10953, 2798, 13907, 2032, 16, 3147, 1942, 6124, 18900, 16, 2019, 2149, 2565, 3]}, "items": [{"id": "p_184", "content": "Pelvic Neoplasms [SEP] Tumors or cancer of the pelvic region.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10953, 15347, 3, 3861, 2014, 2539, 1927, 1920, 10953, 3031, 18, 3]}]}
{"query": {"id": "q_185", "content": "Sexual dysfunction [SEP] Sexual dysfunction among patients with arthritis.", "tokenized_content": [2, 5702, 5273, 3, 5702, 5273, 2706, 2132, 1956, 8884, 18, 3]}, "items": [{"id": "p_185", "content": "Sexual Dysfunction, Physiological [SEP] Physiological disturbances in normal sexual performance in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5702, 5273, 16, 5005, 3, 5005, 12654, 1922, 2791, 5702, 3604, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_186", "content": "arthritis [SEP] Sexual dysfunction among patients with arthritis.", "tokenized_content": [2, 8884, 3, 5702, 5273, 2706, 2132, 1956, 8884, 18, 3]}, "items": [{"id": "p_186", "content": "Arthritis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8884, 3, 3]}]}
{"query": {"id": "q_187", "content": "arthritis [SEP] The relationship of arthritis and sexual dysfunction was investigated among 169 patients with", "tokenized_content": [2, 8884, 3, 1920, 3303, 1927, 8884, 1930, 5702, 5273, 1982, 3845, 2706, 15237, 2132, 1956, 3]}, "items": [{"id": "p_187", "content": "Arthritis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8884, 3, 3]}]}
{"query": {"id": "q_188", "content": "sexual dysfunction [SEP] The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, ", "tokenized_content": [2, 5702, 5273, 3, 1920, 3303, 1927, 8884, 1930, 5702, 5273, 1982, 3845, 2706, 15237, 2132, 1956, 13053, 8884, 16, 3]}, "items": [{"id": "p_188", "content": "Sexual Dysfunction, Physiological [SEP] Physiological disturbances in normal sexual performance in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5702, 5273, 16, 5005, 3, 5005, 12654, 1922, 2791, 5702, 3604, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_189", "content": "rheumatoid arthritis [SEP] and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-", "tokenized_content": [2, 13053, 8884, 3, 1930, 5702, 5273, 1982, 3845, 2706, 15237, 2132, 1956, 13053, 8884, 16, 15027, 1930, 20213, 12729, 5856, 6522, 16, 8761, 1927, 8566, 1985, 3715, 17, 3]}, "items": [{"id": "p_189", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_190", "content": "osteoarthritis [SEP]  was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to contr", "tokenized_content": [2, 15027, 3, 1982, 3845, 2706, 15237, 2132, 1956, 13053, 8884, 16, 15027, 1930, 20213, 12729, 5856, 6522, 16, 8761, 1927, 8566, 1985, 3715, 17, 5992, 1942, 2885, 3]}, "items": [{"id": "p_190", "content": "Osteoarthritis [SEP] A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is though", "score": 1, "type": null, "tokenized_content": [2, 15027, 3, 43, 7529, 16, 15676, 6047, 2573, 16, 1920, 2501, 3059, 2386, 1927, 8884, 16, 4369, 1922, 4706, 7618, 18, 1920, 2573, 1977, 4170, 3]}]}
{"query": {"id": "q_191", "content": "spondyloarthropathy [SEP] mong 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to controls. Assessments of mari", "tokenized_content": [2, 20213, 12729, 5856, 6522, 3, 23659, 15237, 2132, 1956, 13053, 8884, 16, 15027, 1930, 20213, 12729, 5856, 6522, 16, 8761, 1927, 8566, 1985, 3715, 17, 5992, 1942, 3562, 18, 8593, 3]}, "items": [{"id": "p_191", "content": "Spondylarthropathies [SEP] Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN", "score": 1, "type": null, "tokenized_content": [2, 20213, 18956, 7262, 2062, 3, 8538, 2210, 1927, 9273, 7635, 3902, 10763, 2535, 1930, 23048, 4075, 18, 2611, 2032, 2458, 1956, 1920, 7225, 17, 25462, 4730, 3]}]}
{"query": {"id": "q_192", "content": "depressed mood [SEP]  pair-matched to controls. Assessments of marital happiness and depressed mood were also made using the CES-D and the Azrin Marital Happiness ", "tokenized_content": [2, 11365, 9494, 3, 3715, 17, 5992, 1942, 3562, 18, 8593, 1927, 13245, 25748, 1930, 11365, 9494, 1985, 2222, 3915, 2193, 1920, 11641, 17, 46, 1930, 1920, 6352, 5572, 13245, 25748, 3]}, "items": [{"id": "p_192", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_193", "content": "Sexual dysfunctions [SEP] e using the CES-D and the Azrin Marital Happiness Scale (AMHS). Sexual dysfunctions were found to be common among patients and controls, the majori", "tokenized_content": [2, 5702, 24199, 3, 47, 2193, 1920, 11641, 17, 46, 1930, 1920, 6352, 5572, 13245, 25748, 3536, 12, 23295, 1036, 13, 18, 5702, 24199, 1985, 2435, 1942, 1998, 3059, 2706, 2132, 3]}, "items": [{"id": "p_193", "content": "Sexual Dysfunction, Physiological [SEP] Physiological disturbances in normal sexual performance in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5702, 5273, 16, 5005, 3, 5005, 12654, 1922, 2791, 5702, 3604, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_194", "content": "Impotence [SEP] the majority in both groups reporting one or more dysfunctions. Impotence was more common among male patients than controls and was found", "tokenized_content": [2, 2754, 7229, 15895, 1021, 3, 1920, 4827, 1922, 2321, 2671, 6605, 2340, 2014, 2253, 24199, 18, 2754, 7229, 15895, 1021, 1982, 2253, 3059, 2706, 4005, 2132, 2254, 3562, 1930, 1982, 3]}, "items": [{"id": "p_194", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_195", "content": "methotrexate [SEP]  was found to be associated with co-morbidity and the taking of methotrexate. Depressed mood was more common among patients and was associat", "tokenized_content": [2, 18031, 3, 1982, 2435, 1942, 1998, 2458, 1956, 2081, 17, 7207, 1930, 1920, 6303, 1927, 18031, 18, 11365, 9494, 1982, 2253, 3059, 2706, 2132, 1930, 1982, 2293, 1926, 3]}, "items": [{"id": "p_195", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_196", "content": "Depressed mood [SEP] be associated with co-morbidity and the taking of methotrexate. Depressed mood was more common among patients and was associated with certain ", "tokenized_content": [2, 11365, 9494, 3, 1998, 2458, 1956, 2081, 17, 7207, 1930, 1920, 6303, 1927, 18031, 18, 11365, 9494, 1982, 2253, 3059, 2706, 2132, 1930, 1982, 2458, 1956, 4908, 3]}, "items": [{"id": "p_196", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_197", "content": "impotence [SEP] d was associated with certain sexual difficulties, but not with impotence. Marital unhappiness, as indicated by AMHS scores, was not asso", "tokenized_content": [2, 2754, 7229, 15895, 1021, 3, 46, 1982, 2458, 1956, 4908, 5702, 9097, 16, 2308, 2084, 1956, 2754, 7229, 15895, 1021, 18, 13245, 2067, 2722, 9434, 8254, 16, 1966, 3391, 2007, 3]}, "items": [{"id": "p_197", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_198", "content": "paracetamol [SEP] Does paracetamol cause urothelial cancer or renal papillary necrosis?", "tokenized_content": [2, 27021, 3, 3731, 27021, 3936, 23182, 2539, 2014, 4604, 15787, 7476, 35, 3]}, "items": [{"id": "p_198", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_199", "content": "urothelial cancer [SEP] Does paracetamol cause urothelial cancer or renal papillary necrosis?", "tokenized_content": [2, 23182, 2539, 3, 3731, 27021, 3936, 23182, 2539, 2014, 4604, 15787, 7476, 35, 3]}, "items": [{"id": "p_199", "content": "Urethral Neoplasms [SEP] Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Pri", "score": 1, "type": null, "tokenized_content": [2, 20409, 15347, 3, 2539, 2014, 3861, 1927, 1920, 28141, 18, 8867, 4944, 3861, 1927, 1920, 28141, 5394, 3149, 1927, 10364, 1930, 20086, 2094, 18, 17618, 3]}]}
{"query": {"id": "q_200", "content": "renal papillary necrosis [SEP] Does paracetamol cause urothelial cancer or renal papillary necrosis?", "tokenized_content": [2, 4604, 15787, 7476, 3, 3731, 27021, 3936, 23182, 2539, 2014, 4604, 15787, 7476, 35, 3]}, "items": [{"id": "p_200", "content": "Kidney Papillary Necrosis [SEP] A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this ar", "score": 1, "type": null, "tokenized_content": [2, 5245, 15787, 7476, 3, 43, 9388, 1927, 5245, 3902, 4378, 2007, 2024, 3539, 5884, 5245, 14668, 1019, 1922, 1920, 5245, 18755, 18, 22083, 1942, 2052, 2245, 3]}]}
{"query": {"id": "q_201", "content": "renal papillary necrosis [SEP] The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated wit", "tokenized_content": [2, 4604, 15787, 7476, 3, 1920, 2565, 1927, 5130, 4604, 15787, 7476, 2014, 2539, 1927, 1920, 4604, 18152, 16, 15168, 2014, 7821, 2458, 16086, 3]}, "items": [{"id": "p_201", "content": "Kidney Papillary Necrosis [SEP] A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this ar", "score": 1, "type": null, "tokenized_content": [2, 5245, 15787, 7476, 3, 43, 9388, 1927, 5245, 3902, 4378, 2007, 2024, 3539, 5884, 5245, 14668, 1019, 1922, 1920, 5245, 18755, 18, 22083, 1942, 2052, 2245, 3]}]}
{"query": {"id": "q_202", "content": "cancer of the renal pelvis [SEP] The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenac", "tokenized_content": [2, 2539, 1927, 1920, 4604, 18152, 3, 1920, 2565, 1927, 5130, 4604, 15787, 7476, 2014, 2539, 1927, 1920, 4604, 18152, 16, 15168, 2014, 7821, 2458, 1956, 5434, 1927, 3108, 3037, 1948, 3]}, "items": [{"id": "p_202", "content": "Kidney Neoplasms [SEP] Tumors or cancers of the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 15347, 3, 3861, 2014, 5717, 1927, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_203", "content": "phenacetin [SEP] pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnai", "tokenized_content": [2, 3037, 7681, 1921, 3, 18152, 16, 15168, 2014, 7821, 2458, 1956, 5434, 1927, 3108, 3037, 7681, 1921, 2014, 27021, 1982, 3561, 2037, 2230, 5815, 2007, 4880, 1033, 3]}, "items": [{"id": "p_203", "content": "Phenacetin [SEP] A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the mark", "score": 1, "type": null, "tokenized_content": [2, 3037, 7681, 1921, 3, 43, 7971, 27457, 1988, 1982, 22397, 2251, 1922, 21863, 2308, 15582, 1930, 2295, 1987, 7856, 3847, 4866, 1942, 2496, 9594, 2037, 1920, 2937, 3]}]}
{"query": {"id": "q_204", "content": "paracetamol [SEP]  or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cas", "tokenized_content": [2, 27021, 3, 2014, 7821, 2458, 1956, 5434, 1927, 3108, 3037, 7681, 1921, 2014, 27021, 1982, 3561, 2037, 2230, 5815, 2007, 5564, 2037, 27761, 4373, 3]}, "items": [{"id": "p_204", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_205", "content": "ureteric cancer [SEP] the risk for cancer of the renal pelvis and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk ", "tokenized_content": [2, 15168, 1935, 2539, 3, 1920, 2565, 1958, 2539, 1927, 1920, 4604, 18152, 1930, 7821, 2308, 2084, 1958, 15168, 1935, 2539, 18, 2007, 3320, 16, 2038, 1985, 8082, 1942, 21229, 2057, 3]}, "items": [{"id": "p_205", "content": "Ureteral Neoplasms [SEP] Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA", "score": 1, "type": null, "tokenized_content": [2, 24820, 15347, 3, 2539, 2014, 3861, 1927, 1920, 15168, 2154, 2278, 3936, 10849, 4523, 1942, 3290, 2027, 1967, 16, 3290, 2912, 2102, 4870, 16, 1930, 6085, 1938, 22882, 18, 30267, 3]}]}
{"query": {"id": "q_206", "content": "cancers [SEP] etamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer o", "tokenized_content": [2, 5717, 3, 20634, 12492, 1024, 5434, 1958, 4604, 15787, 7476, 2014, 2967, 1927, 2144, 5717, 2876, 2276, 1982, 43, 17848, 1927, 1925, 3279, 1956, 2539, 57, 3]}, "items": [{"id": "p_206", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_207", "content": "cancer of the ureter [SEP]  cancers although there was a suggestion of an association with cancer of the ureter.", "tokenized_content": [2, 2539, 1927, 1920, 15168, 3, 5717, 2876, 2276, 1982, 43, 17848, 1927, 1925, 3279, 1956, 2539, 1927, 1920, 15168, 18, 3]}, "items": [{"id": "p_207", "content": "Ureteral Neoplasms [SEP] Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA", "score": 1, "type": null, "tokenized_content": [2, 24820, 15347, 3, 2539, 2014, 3861, 1927, 1920, 15168, 2154, 2278, 3936, 10849, 4523, 1942, 3290, 2027, 1967, 16, 3290, 2912, 2102, 4870, 16, 1930, 6085, 1938, 22882, 18, 30267, 3]}]}
{"query": {"id": "q_208", "content": "Dapsone [SEP] Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman wit", "tokenized_content": [2, 8243, 5810, 1021, 3, 8243, 5810, 1021, 17, 2458, 2234, 1921, 1011, 3362, 21515, 10679, 1922, 43, 25928, 13968, 1022, 10440, 16086, 3]}, "items": [{"id": "p_208", "content": "Dapsone [SEP] A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanis", "score": 1, "type": null, "tokenized_content": [2, 8243, 5810, 1021, 3, 43, 26265, 1021, 3500, 3316, 43, 4743, 3109, 1927, 4802, 2308, 4994, 5789, 1958, 2496, 7728, 3316, 16389, 24594, 3336, 18, 2496, 2665, 1937, 3]}]}
{"query": {"id": "q_209", "content": "hemolytic anemia [SEP] Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait.", "tokenized_content": [2, 21515, 10679, 3, 8243, 5810, 1021, 17, 2458, 2234, 1921, 1011, 3362, 21515, 10679, 1922, 43, 25928, 13968, 1022, 10440, 1956, 9652, 47, 8823, 18, 3]}, "items": [{"id": "p_209", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_210", "content": "leprosy [SEP] A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of ", "tokenized_content": [2, 25520, 3, 43, 25928, 13968, 1022, 10440, 1956, 9652, 47, 8823, 12, 10194, 13, 1930, 25520, 3530, 43, 2234, 1921, 1011, 3362, 21515, 10679, 2679, 6303, 43, 3253, 1927, 3]}, "items": [{"id": "p_210", "content": "Leprosy [SEP] A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the muco", "score": 1, "type": null, "tokenized_content": [2, 25520, 3, 43, 3724, 26676, 2909, 4189, 2007, 16389, 24594, 3336, 18, 1920, 26676, 4518, 2032, 16687, 1922, 1920, 4407, 16, 1920, 3422, 1037, 3]}]}
{"query": {"id": "q_211", "content": "hemolytic anemia [SEP] with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associat", "tokenized_content": [2, 21515, 10679, 3, 1956, 9652, 47, 8823, 12, 10194, 13, 1930, 25520, 3530, 43, 2234, 1921, 1011, 3362, 21515, 10679, 2679, 6303, 43, 3253, 1927, 8243, 5810, 1021, 12, 2761, 3]}, "items": [{"id": "p_211", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_212", "content": "dapsone [SEP]  developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her", "tokenized_content": [2, 8243, 5810, 1021, 3, 3530, 43, 2234, 1921, 1011, 3362, 21515, 10679, 2679, 6303, 43, 3253, 1927, 8243, 5810, 1021, 12, 2761, 2786, 19, 3007, 13, 2084, 5394, 2458, 1956, 3]}, "items": [{"id": "p_212", "content": "Dapsone [SEP] A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanis", "score": 1, "type": null, "tokenized_content": [2, 8243, 5810, 1021, 3, 43, 26265, 1021, 3500, 3316, 43, 4743, 3109, 1927, 4802, 2308, 4994, 5789, 1958, 2496, 7728, 3316, 16389, 24594, 3336, 18, 2496, 2665, 1937, 3]}]}
{"query": {"id": "q_213", "content": "hemolysis [SEP] ose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body ", "tokenized_content": [2, 22409, 3, 3125, 1021, 1927, 8243, 5810, 1021, 12, 2761, 2786, 19, 3007, 13, 2084, 5394, 2458, 1956, 2535, 22409, 18, 3656, 2312, 2877, 2094, 12, 16619, 13, 2430, 2502, 3]}, "items": [{"id": "p_213", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_214", "content": "glutathione [SEP] had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH stability. The pentose phosphate shunt", "tokenized_content": [2, 9153, 3, 2430, 2502, 3984, 2234, 1921, 1011, 3362, 3337, 16, 3261, 3028, 9153, 12, 9973, 13, 16, 1930, 3261, 9973, 5057, 18, 1920, 9412, 2217, 5413, 17157, 3]}, "items": [{"id": "p_214", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_215", "content": "GSH [SEP]  incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH stability. The pentose phosphate shunt acti", "tokenized_content": [2, 9973, 3, 3984, 2234, 1921, 1011, 3362, 3337, 16, 3261, 3028, 9153, 12, 9973, 13, 16, 1930, 3261, 9973, 5057, 18, 1920, 9412, 2217, 5413, 17157, 4033, 1033, 3]}, "items": [{"id": "p_215", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_216", "content": "pentose phosphate [SEP] sed reduced glutathione (GSH), and decreased GSH stability. The pentose phosphate shunt activity of the dapsone-exposed AE RBCs was increased com", "tokenized_content": [2, 9412, 2217, 5413, 3, 6276, 3028, 9153, 12, 9973, 13, 16, 1930, 3261, 9973, 5057, 18, 1920, 9412, 2217, 5413, 17157, 2455, 1927, 1920, 8243, 5810, 1021, 17, 4616, 10194, 3]}, "items": [{"id": "p_216", "content": "Pentosephosphates [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9412, 2217, 25324, 1036, 3, 3]}]}
{"query": {"id": "q_217", "content": "infection [SEP] idant medications should be used with caution, especially if an infection is present, in individuals of ethnic backgrounds that have an i", "tokenized_content": [2, 2909, 3, 29930, 4905, 7719, 3066, 1998, 2251, 1956, 12838, 16, 4369, 2647, 1925, 2909, 1977, 2481, 16, 1922, 3445, 1927, 8639, 15650, 1988, 2162, 1925, 51, 3]}, "items": [{"id": "p_217", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_218", "content": "metoprolol [SEP] l drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.", "tokenized_content": [2, 2130, 17712, 1945, 3, 54, 2838, 3181, 1922, 43, 2774, 2899, 1966, 43, 3930, 3074, 10052, 1927, 2130, 17712, 1945, 16, 5062, 13085, 2290, 16, 4333, 11574, 6931, 1035, 16, 3]}, "items": [{"id": "p_218", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_219", "content": "propafenone [SEP] py in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.", "tokenized_content": [2, 5062, 13085, 2290, 3, 6085, 1922, 43, 2774, 2899, 1966, 43, 3930, 3074, 10052, 1927, 2130, 17712, 1945, 16, 5062, 13085, 2290, 16, 4333, 11574, 6931, 1035, 16, 1930, 25547, 3]}, "items": [{"id": "p_219", "content": "Propafenone [SEP] An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5062, 13085, 2290, 3, 1925, 2246, 23246, 6026, 5899, 1988, 1977, 4443, 3655, 1922, 6493, 16934, 18, 2176, 2222, 2258, 5015, 4666, 17, 7472, 2455, 18, 3]}]}
{"query": {"id": "q_220", "content": "diltiazem [SEP] nt identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 5891, 2899, 1966, 43, 3930, 3074, 10052, 1927, 2130, 17712, 1945, 16, 5062, 13085, 2290, 16, 4333, 11574, 6931, 1035, 16, 1930, 25547, 7595, 18, 3]}, "items": [{"id": "p_220", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_221", "content": "sparteine [SEP] s a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.", "tokenized_content": [2, 25547, 7595, 3, 61, 43, 3930, 3074, 10052, 1927, 2130, 17712, 1945, 16, 5062, 13085, 2290, 16, 4333, 11574, 6931, 1035, 16, 1930, 25547, 7595, 18, 3]}, "items": [{"id": "p_221", "content": "Sparteine [SEP] A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytoci", "score": 1, "type": null, "tokenized_content": [2, 25547, 7595, 3, 43, 9012, 8436, 27767, 2053, 29951, 3937, 2037, 2980, 6914, 9914, 2710, 12555, 22214, 31, 25547, 11254, 31, 1930, 2702, 1937, 1957, 18, 2176, 2258, 2252, 2251, 1966, 1925, 16462, 2240, 3]}]}
{"query": {"id": "q_222", "content": "coronary artery disease [SEP] A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hyp", "tokenized_content": [2, 5846, 5511, 2573, 3, 43, 4261, 17, 2476, 17, 4156, 2774, 11364, 2037, 5846, 5511, 2573, 1982, 9723, 1942, 1920, 4928, 1032, 1922, 7418, 1956, 4337, 18, 2781, 3367, 16, 3]}, "items": [{"id": "p_222", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_223", "content": "shock [SEP] ffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventr", "tokenized_content": [2, 7418, 3, 10735, 6417, 2037, 5846, 5511, 2573, 1982, 9723, 1942, 1920, 4928, 1032, 1922, 7418, 1956, 4337, 18, 2781, 3367, 16, 4010, 16453, 16, 1930, 6159, 1927, 4699, 3]}, "items": [{"id": "p_223", "content": "Shock [SEP] A pathological condition manifested by failure to perfuse or oxygenate vital organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7418, 3, 43, 6598, 2625, 16687, 2007, 4574, 1942, 5294, 2517, 2014, 4612, 2010, 8970, 7393, 18, 3]}]}
{"query": {"id": "q_224", "content": "AV block [SEP] onary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. On", "tokenized_content": [2, 2781, 3367, 3, 1990, 2141, 5511, 2573, 1982, 9723, 1942, 1920, 4928, 1032, 1922, 7418, 1956, 4337, 18, 2781, 3367, 16, 4010, 16453, 16, 1930, 6159, 1927, 6493, 2347, 18, 3]}, "items": [{"id": "p_224", "content": "Atrioventricular Block [SEP] Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduc", "score": 1, "type": null, "tokenized_content": [2, 28355, 3367, 3, 5761, 21896, 12382, 2037, 4003, 26500, 1019, 1942, 4003, 21008, 18, 2781, 3367, 2112, 2667, 7083, 2014, 5796, 6923, 21896, 3164, 3]}]}
{"query": {"id": "q_225", "content": "hypotension [SEP] ase was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admi", "tokenized_content": [2, 16453, 3, 28826, 1982, 9723, 1942, 1920, 4928, 1032, 1922, 7418, 1956, 4337, 18, 2781, 3367, 16, 4010, 16453, 16, 1930, 6159, 1927, 6493, 2347, 18, 2340, 2982, 3432, 1942, 3]}, "items": [{"id": "p_225", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_226", "content": "impairment of ventricular function [SEP] to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of m", "tokenized_content": [2, 6159, 1927, 6493, 2347, 3, 1942, 1920, 4928, 1032, 1922, 7418, 1956, 4337, 18, 2781, 3367, 16, 4010, 16453, 16, 1930, 6159, 1927, 6493, 2347, 18, 2340, 2982, 3432, 1942, 3]}, "items": [{"id": "p_226", "content": "Ventricular Dysfunction [SEP] A condition in which HEART VENTRICLES exhibit impaired function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6493, 5273, 3, 43, 2625, 1922, 2154, 4003, 21008, 5987, 5761, 2347, 18, 3]}]}
{"query": {"id": "q_227", "content": "metoprolol [SEP] n. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two ", "tokenized_content": [2, 2130, 17712, 1945, 3, 56, 18, 2340, 2982, 3432, 1942, 7682, 43, 3181, 1956, 2970, 5312, 1927, 2130, 17712, 1945, 12, 2813, 2786, 62, 18, 51, 18, 46, 18, 1930, 3]}, "items": [{"id": "p_227", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_228", "content": "diltiazem [SEP] en 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood ", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 2066, 2813, 2786, 44, 18, 51, 18, 46, 18, 13, 2430, 2252, 7796, 18, 2288, 3000, 3119, 7682, 4333, 11574, 6931, 1035, 12, 3276, 2786, 3]}, "items": [{"id": "p_228", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_229", "content": "propafenone [SEP]  patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and sparteine (a", "tokenized_content": [2, 5062, 13085, 2290, 3, 2774, 1982, 4616, 1942, 43, 2957, 3253, 1927, 2130, 17712, 1945, 16, 4333, 11574, 6931, 1035, 16, 5062, 13085, 2290, 12, 3328, 2234, 2430, 4004, 2052, 3]}, "items": [{"id": "p_229", "content": "Propafenone [SEP] An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5062, 13085, 2290, 3, 1925, 2246, 23246, 6026, 5899, 1988, 1977, 4443, 3655, 1922, 6493, 16934, 18, 2176, 2222, 2258, 5015, 4666, 17, 7472, 2455, 18, 3]}]}
{"query": {"id": "q_230", "content": "sparteine [SEP]  propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of", "tokenized_content": [2, 25547, 7595, 3, 5062, 13085, 2290, 12, 3328, 2234, 2430, 4004, 2052, 2838, 1922, 1920, 5375, 13, 16, 1930, 25547, 7595, 12, 1966, 43, 5598, 1958, 1920, 14347, 1037, 15520, 3]}, "items": [{"id": "p_230", "content": "Sparteine [SEP] A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytoci", "score": 1, "type": null, "tokenized_content": [2, 25547, 7595, 3, 43, 9012, 8436, 27767, 2053, 29951, 3937, 2037, 2980, 6914, 9914, 2710, 12555, 22214, 31, 25547, 11254, 31, 1930, 2702, 1937, 1957, 18, 2176, 2258, 2252, 2251, 1966, 1925, 16462, 2240, 3]}]}
{"query": {"id": "q_231", "content": "debrisoquine [SEP] eived this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It w", "tokenized_content": [2, 14347, 1037, 15520, 3, 16101, 2173, 2052, 2838, 1922, 1920, 5375, 13, 16, 1930, 25547, 7595, 12, 1966, 43, 5598, 1958, 1920, 14347, 1037, 15520, 19, 25547, 7595, 2601, 8218, 3]}, "items": [{"id": "p_231", "content": "Debrisoquin [SEP] An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorp", "score": 1, "type": null, "tokenized_content": [2, 14347, 1037, 11072, 3, 1925, 13672, 7428, 17, 7472, 2838, 2551, 1922, 2564, 1942, 13504, 3184, 5802, 18, 2176, 1977, 2222, 13884, 1922, 3301, 43, 4510, 1958, 43, 3491, 12157, 3]}]}
{"query": {"id": "q_232", "content": "adverse drug reactions [SEP] which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. M", "tokenized_content": [2, 5246, 2838, 5298, 3, 2154, 14879, 26, 18, 24, 9, 1927, 1920, 12194, 2973, 16, 2278, 4848, 5246, 2838, 5298, 2469, 2868, 1956, 2970, 5312, 1927, 2340, 1927, 2144, 4195, 3]}, "items": [{"id": "p_232", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_233", "content": "Triazolam [SEP] Triazolam-induced brief episodes of secondary mania in a depressed patien", "tokenized_content": [2, 5083, 21585, 3, 5083, 21585, 17, 2719, 5310, 9232, 1927, 4067, 28864, 1922, 43, 11365, 2091, 1917, 3]}, "items": [{"id": "p_233", "content": "Triazolam [SEP] A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market b", "score": 1, "type": null, "tokenized_content": [2, 5083, 21585, 3, 43, 3662, 17, 8290, 27266, 2251, 1922, 1920, 2311, 1927, 16882, 18, 2673, 5085, 24469, 1956, 3883, 2370, 5083, 21585, 2037, 1920, 10878, 44, 3]}]}
{"query": {"id": "q_234", "content": "mania [SEP] Triazolam-induced brief episodes of secondary mania in a depressed patient.", "tokenized_content": [2, 28864, 3, 5083, 21585, 17, 2719, 5310, 9232, 1927, 4067, 28864, 1922, 43, 11365, 2774, 18, 3]}, "items": [{"id": "p_234", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_235", "content": "depressed [SEP] Triazolam-induced brief episodes of secondary mania in a depressed patient.", "tokenized_content": [2, 11365, 3, 5083, 21585, 17, 2719, 5310, 9232, 1927, 4067, 28864, 1922, 43, 11365, 2774, 18, 3]}, "items": [{"id": "p_235", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_236", "content": "triazolam [SEP] Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elder", "tokenized_content": [2, 5083, 21585, 3, 3103, 5312, 1927, 5083, 21585, 14959, 2719, 5310, 9232, 1927, 28864, 1922, 43, 11365, 7177, 3]}, "items": [{"id": "p_236", "content": "Triazolam [SEP] A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market b", "score": 1, "type": null, "tokenized_content": [2, 5083, 21585, 3, 43, 3662, 17, 8290, 27266, 2251, 1922, 1920, 2311, 1927, 16882, 18, 2673, 5085, 24469, 1956, 3883, 2370, 5083, 21585, 2037, 1920, 10878, 44, 3]}]}
{"query": {"id": "q_237", "content": "mania [SEP] Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disord", "tokenized_content": [2, 28864, 3, 3103, 5312, 1927, 5083, 21585, 14959, 2719, 5310, 9232, 1927, 28864, 1922, 43, 11365, 7354, 10440, 18, 4075, 1927, 6805, 5018, 2054, 2538, 3]}, "items": [{"id": "p_237", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_238", "content": "depressed [SEP] es of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) w", "tokenized_content": [2, 11365, 3, 2376, 1927, 5083, 21585, 14959, 2719, 5310, 9232, 1927, 28864, 1922, 43, 11365, 7354, 10440, 18, 4075, 1927, 6805, 5018, 4770, 12, 18166, 13, 65, 3]}, "items": [{"id": "p_238", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_239", "content": "organic mental disorder [SEP] ief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident wi", "tokenized_content": [2, 6805, 5018, 4770, 3, 10116, 1038, 9232, 1927, 28864, 1922, 43, 11365, 7354, 10440, 18, 4075, 1927, 6805, 5018, 4770, 12, 18166, 13, 1985, 2084, 2481, 18, 2323, 1935, 7817, 3]}, "items": [{"id": "p_239", "content": "Delirium, Dementia, Amnestic, Cognitive Disorders [SEP] Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, traum", "score": 1, "type": null, "tokenized_content": [2, 18166, 16, 7811, 16, 14701, 8396, 16, 4328, 4414, 3, 4328, 4414, 2710, 18166, 16, 7811, 16, 1930, 2303, 4328, 4414, 18, 2144, 2278, 1998, 1920, 3211, 1927, 7311, 2485, 16, 5832, 3]}]}
{"query": {"id": "q_240", "content": "delirium [SEP] a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the dur", "tokenized_content": [2, 18166, 3, 43, 11365, 7354, 10440, 18, 4075, 1927, 6805, 5018, 4770, 12, 18166, 13, 1985, 2084, 2481, 18, 2323, 1935, 7817, 2855, 1982, 22829, 1956, 1920, 2335, 3]}, "items": [{"id": "p_240", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_241", "content": "Manic [SEP] eatures of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazo", "tokenized_content": [2, 2323, 1935, 3, 13619, 2352, 1927, 6805, 5018, 4770, 12, 18166, 13, 1985, 2084, 2481, 18, 2323, 1935, 7817, 2855, 1982, 22829, 1956, 1920, 4392, 1927, 4615, 1927, 5083, 19370, 3]}, "items": [{"id": "p_241", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_242", "content": "triazolo [SEP] ration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is discussed.", "tokenized_content": [2, 5083, 10457, 1037, 3, 12488, 1927, 4615, 1927, 5083, 21585, 18, 1920, 3216, 5100, 1927, 1920, 5083, 10457, 1037, 2210, 1942, 2840, 1922, 11863, 3642, 1977, 5601, 18, 3]}, "items": [{"id": "p_242", "content": "Triazolam [SEP] A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market b", "score": 1, "type": null, "tokenized_content": [2, 5083, 21585, 3, 43, 3662, 17, 8290, 27266, 2251, 1922, 1920, 2311, 1927, 16882, 18, 2673, 5085, 24469, 1956, 3883, 2370, 5083, 21585, 2037, 1920, 10878, 44, 3]}]}
{"query": {"id": "q_243", "content": "muscular rigidity [SEP] On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats.", "tokenized_content": [2, 12330, 20471, 3, 1990, 1920, 3531, 1927, 1920, 2740, 1927, 6555, 1942, 1920, 12330, 20471, 4152, 2007, 11553, 1922, 3615, 18, 3]}, "items": [{"id": "p_243", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_244", "content": "morphine [SEP] e development of tolerance to the muscular rigidity produced by morphine in rats.", "tokenized_content": [2, 11553, 3, 47, 2740, 1927, 6555, 1942, 1920, 12330, 20471, 4152, 2007, 11553, 1922, 3615, 18, 3]}, "items": [{"id": "p_244", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_245", "content": "muscular rigidity [SEP] The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated con", "tokenized_content": [2, 12330, 20471, 3, 1920, 2740, 1927, 6555, 1942, 1920, 12330, 20471, 4152, 2007, 11553, 1982, 3942, 1922, 3615, 18, 5977, 17, 12152, 1962, 3]}, "items": [{"id": "p_245", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_246", "content": "morphine [SEP] e development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test do", "tokenized_content": [2, 11553, 3, 47, 2740, 1927, 6555, 1942, 1920, 12330, 20471, 4152, 2007, 11553, 1982, 3942, 1922, 3615, 18, 5977, 17, 12152, 3562, 3258, 43, 2648, 2608, 3]}, "items": [{"id": "p_246", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_247", "content": "rigidity [SEP] The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated con", "tokenized_content": [2, 20471, 3, 1920, 2740, 1927, 6555, 1942, 1920, 12330, 20471, 4152, 2007, 11553, 1982, 3942, 1922, 3615, 18, 5977, 17, 12152, 1962, 3]}, "items": [{"id": "p_247", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_248", "content": "akinetic [SEP] e that was not significantly less than in the controls and were akinetic (A group). The other rats showed a strong decrease in the rigid", "tokenized_content": [2, 26162, 3023, 3, 47, 1988, 1982, 2084, 2567, 2941, 2254, 1922, 1920, 3562, 1930, 1985, 26162, 3023, 12, 43, 2210, 13, 18, 1920, 2303, 3615, 2594, 43, 3206, 3714, 1922, 3]}, "items": [{"id": "p_248", "content": "Hypokinesia [SEP] Slow or diminished movement of body musculature. It may be associated with BASAL GANGLIA DISEASES; MENTAL DISORDERS; prolonged i", "score": 1, "type": null, "tokenized_content": [2, 14395, 26682, 3, 5470, 2014, 9597, 5829, 1927, 3362, 25795, 2541, 18, 2176, 2278, 1998, 2458, 1956, 5342, 13086, 3902, 31, 5018, 4414, 31, 7171, 51, 3]}]}
{"query": {"id": "q_249", "content": "hyperkinetic [SEP] ereotyped (S) licking and/or gnawing in presence of akinetic or hyperkinetic (K) behaviour (AS/KS group), suggesting signs of dopaminergic a", "tokenized_content": [2, 4194, 24590, 2002, 3, 22561, 23096, 12, 61, 13, 10247, 18046, 1930, 19, 2014, 9005, 22738, 2029, 1922, 2990, 1927, 26162, 3023, 2014, 4194, 24590, 2002, 12, 53, 13, 6270, 3]}, "items": [{"id": "p_249", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_250", "content": "haloperidol [SEP] s after 20 days' treatment. In a further series of experiments, haloperidol (0.2 mg/kg i.p.) was used in order to block the dopaminergic ac", "tokenized_content": [2, 25107, 3, 61, 2256, 2036, 3000, 11, 2311, 18, 1922, 43, 2520, 4696, 1927, 3144, 16, 25107, 12, 20, 18, 22, 2786, 19, 3621, 51, 18, 58, 18, 13, 1982, 3]}, "items": [{"id": "p_250", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_251", "content": "Haloperidol [SEP] olerance to the rigidity without any dopaminergic interference. Haloperidol enhanced the rigidity in the A group. However, the level in the", "tokenized_content": [2, 25107, 3, 12188, 22900, 1942, 1920, 20471, 2979, 2967, 12214, 8703, 18, 25107, 4256, 1920, 20471, 1922, 1920, 43, 2210, 18, 2406, 16, 1920, 2237, 1922, 1920, 3]}, "items": [{"id": "p_251", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_252", "content": "Compression neuropathy [SEP] Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy", "tokenized_content": [2, 10399, 13177, 3, 10399, 13177, 1927, 1920, 10575, 5507, 2810, 1942, 9412, 19370, 11388, 17, 2719, 15711, 25017, 3]}, "items": [{"id": "p_252", "content": "Nerve Compression Syndromes [SEP] Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerv", "score": 1, "type": null, "tokenized_content": [2, 5507, 10399, 12688, 3, 5821, 10399, 1927, 12014, 2014, 5507, 9398, 2037, 4495, 2014, 5771, 5092, 18, 2144, 2278, 3211, 1922, 43, 12382, 3367, 1942, 7342, 3]}]}
{"query": {"id": "q_253", "content": "neuropathy of the radial nerve [SEP] Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy.", "tokenized_content": [2, 13177, 1927, 1920, 10575, 5507, 3, 10399, 13177, 1927, 1920, 10575, 5507, 2810, 1942, 9412, 19370, 11388, 17, 2719, 15711, 25017, 18, 3]}, "items": [{"id": "p_253", "content": "Radial Neuropathy [SEP] Disease involving the RADIAL NERVE. Clinical features include weakness of elbow extension, elbow flexion, supination of the fore", "score": 1, "type": null, "tokenized_content": [2, 10575, 13177, 3, 2573, 5884, 1920, 10575, 5507, 18, 2535, 4075, 3951, 12175, 1927, 17621, 7140, 16, 17621, 13326, 16, 2302, 2636, 1927, 1920, 9023, 3]}]}
{"query": {"id": "q_254", "content": "pentazocine [SEP] Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy.", "tokenized_content": [2, 9412, 19370, 11388, 3, 10399, 13177, 1927, 1920, 10575, 5507, 2810, 1942, 9412, 19370, 11388, 17, 2719, 15711, 25017, 18, 3]}, "items": [{"id": "p_254", "content": "Pentazocine [SEP] The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a ", "score": 1, "type": null, "tokenized_content": [2, 9412, 19370, 11388, 3, 1920, 2561, 4985, 7829, 17, 8151, 14501, 1942, 1998, 28392, 18, 2176, 1977, 1925, 7829, 2019, 1920, 12093, 1930, 5139, 9384, 4086, 1930, 2258, 43, 3]}]}
{"query": {"id": "q_255", "content": "pentazocine [SEP] ibrous myopathy is a common, well-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic musc", "tokenized_content": [2, 9412, 19370, 11388, 3, 25138, 2080, 25017, 1977, 43, 3059, 16, 2486, 17, 3171, 4159, 2495, 1927, 5116, 9412, 19370, 11388, 4107, 18, 2406, 16, 10399, 13177, 2810, 1942, 16123, 3]}, "items": [{"id": "p_255", "content": "Pentazocine [SEP] The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a ", "score": 1, "type": null, "tokenized_content": [2, 9412, 19370, 11388, 3, 1920, 2561, 4985, 7829, 17, 8151, 14501, 1942, 1998, 28392, 18, 2176, 1977, 1925, 7829, 2019, 1920, 12093, 1930, 5139, 9384, 4086, 1930, 2258, 43, 3]}]}
{"query": {"id": "q_256", "content": "compression neuropathy [SEP] l-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine-induced myopathy", "tokenized_content": [2, 10399, 13177, 3, 54, 17, 3171, 4159, 2495, 1927, 5116, 9412, 19370, 11388, 4107, 18, 2406, 16, 10399, 13177, 2810, 1942, 16123, 3760, 4218, 2007, 9412, 19370, 11388, 17, 2719, 3]}, "items": [{"id": "p_256", "content": "Nerve Compression Syndromes [SEP] Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerv", "score": 1, "type": null, "tokenized_content": [2, 5507, 10399, 12688, 3, 5821, 10399, 1927, 12014, 2014, 5507, 9398, 2037, 4495, 2014, 5771, 5092, 18, 2144, 2278, 3211, 1922, 43, 12382, 3367, 1942, 7342, 3]}]}
{"query": {"id": "q_257", "content": "myopathy [SEP] Fibrous myopathy is a common, well-known side effect of repeated pentazocine inj", "tokenized_content": [2, 25017, 3, 15711, 25017, 1977, 43, 3059, 16, 2486, 17, 3171, 4159, 2495, 1927, 5116, 9412, 19370, 11388, 2831, 3]}, "items": [{"id": "p_257", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_258", "content": "acute renal failure [SEP] Recurrent reversible acute renal failure from amphotericin.", "tokenized_content": [2, 3939, 4604, 4574, 3, 7457, 10743, 3939, 4604, 4574, 2037, 23210, 18, 3]}, "items": [{"id": "p_258", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_259", "content": "amphotericin [SEP] Recurrent reversible acute renal failure from amphotericin.", "tokenized_content": [2, 23210, 3, 7457, 10743, 3939, 4604, 4574, 2037, 23210, 18, 3]}, "items": [{"id": "p_259", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_260", "content": "cirrhosis [SEP] A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure i", "tokenized_content": [2, 11260, 3, 43, 2774, 1956, 11829, 3880, 11260, 1930, 17593, 9130, 18935, 28226, 8362, 3530, 3939, 4604, 4574, 51, 3]}, "items": [{"id": "p_260", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_261", "content": "sporotrichosis [SEP] A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the adminis", "tokenized_content": [2, 9130, 18935, 28226, 8362, 3, 43, 2774, 1956, 11829, 3880, 11260, 1930, 17593, 9130, 18935, 28226, 8362, 3530, 3939, 4604, 4574, 6183, 2894, 1920, 3318, 1937, 3]}, "items": [{"id": "p_261", "content": "Sporotrichosis [SEP] The commonest and least serious of the deep mycoses, characterized by nodular lesions of the cutaneous and subcutaneous tissues.", "score": 1, "type": null, "tokenized_content": [2, 9130, 18935, 28226, 8362, 3, 1920, 29200, 1930, 3464, 7433, 1927, 1920, 6515, 5078, 12278, 16, 4378, 2007, 21106, 4518, 1927, 1920, 11276, 1930, 8634, 3878, 18, 3]}]}
{"query": {"id": "q_262", "content": "acute renal failure [SEP] cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on f", "tokenized_content": [2, 3939, 4604, 4574, 3, 11829, 3880, 11260, 1930, 17593, 9130, 18935, 28226, 8362, 3530, 3939, 4604, 4574, 6183, 2894, 1920, 4183, 1927, 23210, 44, 1990, 48, 3]}, "items": [{"id": "p_262", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_263", "content": "amphotericin B [SEP] acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure", "tokenized_content": [2, 23210, 44, 3, 3939, 4604, 4574, 6183, 2894, 1920, 4183, 1927, 23210, 44, 1990, 3006, 5850, 18513, 18, 1920, 20135, 2971, 1927, 1920, 4604, 4574, 3]}, "items": [{"id": "p_263", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_264", "content": "renal failure [SEP] genic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on f", "tokenized_content": [2, 4604, 4574, 3, 26860, 11260, 1930, 17593, 9130, 18935, 28226, 8362, 3530, 3939, 4604, 4574, 6183, 2894, 1920, 4183, 1927, 23210, 44, 1990, 48, 3]}, "items": [{"id": "p_264", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_265", "content": "renal dysfunction [SEP] thin days suggests that there was a functional component to the renal dysfunction. We propose that amphotericin, in the setting of reduced effect", "tokenized_content": [2, 4604, 5273, 3, 7568, 3000, 4015, 1988, 2276, 1982, 43, 3183, 4594, 1942, 1920, 4604, 5273, 18, 2038, 8040, 1988, 23210, 16, 1922, 1920, 4308, 1927, 3028, 2495, 3]}, "items": [{"id": "p_265", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_266", "content": "amphotericin [SEP] acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failu", "tokenized_content": [2, 23210, 3, 3939, 4604, 4574, 6183, 2894, 1920, 4183, 1927, 23210, 44, 1990, 3006, 5850, 18513, 18, 1920, 20135, 2971, 1927, 1920, 4604, 3627, 1032, 3]}, "items": [{"id": "p_266", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_267", "content": "pericardial effusion [SEP] Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.", "tokenized_content": [2, 22188, 17673, 3, 24560, 3678, 1956, 14117, 1930, 22188, 17673, 1930, 13177, 2409, 15665, 25033, 2830, 1021, 3181, 18, 3]}, "items": [{"id": "p_267", "content": "Pericardial Effusion [SEP] Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associa", "score": 1, "type": null, "tokenized_content": [2, 22188, 17673, 3, 5466, 4858, 2651, 1920, 10796, 26872, 18, 19965, 17673, 1036, 2032, 2458, 1956, 22188, 3902, 18, 3243, 3556, 6102, 8544, 2457, 1977, 2293, 1019, 3]}]}
{"query": {"id": "q_268", "content": "neuropathy [SEP] Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.", "tokenized_content": [2, 13177, 3, 24560, 3678, 1956, 14117, 1930, 22188, 17673, 1930, 13177, 2409, 15665, 25033, 2830, 1021, 3181, 18, 3]}, "items": [{"id": "p_268", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_269", "content": "amiodarone [SEP] tis with pleural and pericardial effusion and neuropathy during amiodarone therapy.", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 30152, 1956, 14117, 1930, 22188, 17673, 1930, 13177, 2409, 15665, 25033, 2830, 1021, 3181, 18, 3]}, "items": [{"id": "p_269", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_270", "content": "sinuatrial disease [SEP] A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum do", "tokenized_content": [2, 3132, 12169, 17075, 2573, 3, 43, 2774, 1956, 3132, 12169, 17075, 2573, 1930, 10978, 20876, 1982, 2868, 1956, 15665, 25033, 2830, 1021, 12, 4419, 2608, 3]}, "items": [{"id": "p_270", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_271", "content": "amiodarone [SEP] ith sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 mo", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 24737, 3132, 12169, 17075, 2573, 1930, 10978, 20876, 1982, 2868, 1956, 15665, 25033, 2830, 1021, 12, 4419, 3253, 5672, 2786, 16, 6291, 3253, 9658, 2786, 3]}, "items": [{"id": "p_271", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_272", "content": "supraventricular tachyarrhythmias [SEP] g, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, a", "tokenized_content": [2, 21038, 24722, 12762, 9771, 18858, 10245, 15519, 3, 49, 16, 6291, 3253, 9658, 2786, 4692, 13, 1958, 2119, 3221, 16, 1958, 2285, 1927, 21038, 24722, 12762, 9771, 18858, 10245, 15519, 3]}, "items": [{"id": "p_272", "content": "Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 21038, 24722, 3, 43, 13459, 2294, 1958, 2967, 17397, 1988, 22970, 3538, 1920, 14142, 1927, 4167, 18, 3]}]}
{"query": {"id": "q_273", "content": "pneumonitis [SEP]  for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proxima", "tokenized_content": [2, 24560, 3678, 3, 1958, 2285, 1927, 21038, 24722, 12762, 9771, 18858, 10245, 15519, 18, 2234, 3530, 24560, 3678, 16, 14117, 1930, 22188, 17673, 1036, 16, 1930, 43, 7700, 5718, 1019, 3]}, "items": [{"id": "p_273", "content": "Pneumonia [SEP] Inflammation of any part, segment or lobe, of the lung parenchyma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7868, 3, 4531, 1927, 2967, 3131, 16, 5367, 2014, 9581, 16, 1927, 1920, 3614, 15214, 18, 3]}]}
{"query": {"id": "q_274", "content": "pericardial effusions [SEP] ricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immediate but g", "tokenized_content": [2, 22188, 17673, 1036, 3, 18091, 2168, 12762, 9771, 18858, 10245, 15519, 18, 2234, 3530, 24560, 3678, 16, 14117, 1930, 22188, 17673, 1036, 16, 1930, 43, 7700, 6863, 4842, 13177, 18, 3]}, "items": [{"id": "p_274", "content": "Pericardial Effusion [SEP] Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associa", "score": 1, "type": null, "tokenized_content": [2, 22188, 17673, 3, 5466, 4858, 2651, 1920, 10796, 26872, 18, 19965, 17673, 1036, 2032, 2458, 1956, 22188, 3902, 18, 3243, 3556, 6102, 8544, 2457, 1977, 2293, 1019, 3]}]}
{"query": {"id": "q_275", "content": "proximal motor neuropathy [SEP] monitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immediate but gradual improvement followed withdrawal of amiod", "tokenized_content": [2, 6863, 4842, 13177, 3, 3989, 1937, 16, 14117, 1930, 22188, 17673, 1036, 16, 1930, 43, 7700, 6863, 4842, 13177, 18, 8426, 2308, 13802, 4990, 3489, 9594, 1927, 15665, 1986, 3]}, "items": [{"id": "p_275", "content": "Neuromuscular Diseases [SEP] A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manif", "score": 1, "type": null, "tokenized_content": [2, 15829, 3902, 3, 43, 3335, 2576, 17527, 2826, 4842, 7428, 2573, 31, 5009, 7580, 2433, 3902, 31, 1930, 4908, 12330, 3902, 18, 6747, 3]}]}
{"query": {"id": "q_276", "content": "prednisolone [SEP] mprovement followed withdrawal of amiodarone and treatment with prednisolone. Review of this and previously reported cases indicates the nee", "tokenized_content": [2, 22025, 3, 23063, 3245, 2017, 3489, 9594, 1927, 15665, 25033, 2830, 1021, 1930, 2311, 1956, 22025, 18, 3043, 1927, 2052, 1930, 3024, 2568, 2919, 4538, 1920, 2069, 1021, 3]}, "items": [{"id": "p_276", "content": "Prednisolone [SEP] A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routin", "score": 1, "type": null, "tokenized_content": [2, 22025, 3, 43, 14469, 1956, 1920, 3335, 3879, 1927, 1920, 14610, 18, 2176, 1977, 1920, 2838, 1927, 6259, 1958, 2136, 2961, 1922, 2154, 10276, 3]}]}
{"query": {"id": "q_277", "content": "steroid [SEP] s, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.", "tokenized_content": [2, 9507, 3, 61, 16, 8426, 9594, 1927, 15665, 25033, 2830, 1021, 16, 1930, 14393, 2308, 7583, 9507, 3181, 1942, 6486, 4125, 5241, 18, 3]}, "items": [{"id": "p_277", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_278", "content": "Indomethacin [SEP] Indomethacin-induced renal insufficiency: recurrence on rechallenge.", "tokenized_content": [2, 20463, 3, 20463, 17, 2719, 4604, 14566, 30, 6339, 1990, 27317, 2214, 26464, 18, 3]}, "items": [{"id": "p_278", "content": "Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla", "score": 1, "type": null, "tokenized_content": [2, 20463, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 7042, 1920, 4113, 21271, 4680, 1958, 1920, 3337, 1927, 4876, 15915, 1019, 3]}]}
{"query": {"id": "q_279", "content": "renal insufficiency [SEP] Indomethacin-induced renal insufficiency: recurrence on rechallenge.", "tokenized_content": [2, 4604, 14566, 3, 20463, 17, 2719, 4604, 14566, 30, 6339, 1990, 27317, 2214, 26464, 18, 3]}, "items": [{"id": "p_279", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_280", "content": "renal failure [SEP] We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor", "tokenized_content": [2, 4604, 4574, 3, 2038, 2162, 2568, 43, 3087, 1927, 3939, 4833, 15861, 4604, 4574, 1956, 4194, 7640, 1952, 6026, 1922, 43, 2774, 1956, 11260, 16, 17622, 16, 1930, 2233, 3]}, "items": [{"id": "p_280", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_281", "content": "hyperkalemia [SEP] We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after i", "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 2038, 2162, 2568, 43, 3087, 1927, 3939, 4833, 15861, 4604, 4574, 1956, 4194, 7640, 1952, 6026, 1922, 43, 2774, 1956, 11260, 16, 17622, 16, 1930, 3]}, "items": [{"id": "p_281", "content": "Hyperkalemia [SEP] Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinicall", "score": 1, "type": null, "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 20756, 2149, 9057, 3110, 1922, 1920, 2877, 16, 2501, 3868, 2810, 1942, 9785, 4604, 11093, 18, 2176, 1977, 4378, 2535, 1024, 3]}]}
{"query": {"id": "q_282", "content": "cirrhosis [SEP] cute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt ", "tokenized_content": [2, 11260, 3, 4665, 1021, 4833, 15861, 4604, 4574, 1956, 4194, 7640, 1952, 6026, 1922, 43, 2774, 1956, 11260, 16, 17622, 16, 1930, 2233, 3784, 3947, 2603, 2256, 20463, 3181, 18, 3]}, "items": [{"id": "p_282", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_283", "content": "ascites [SEP] ic renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restorati", "tokenized_content": [2, 17622, 3, 3996, 4604, 4574, 1956, 4194, 7640, 1952, 6026, 1922, 43, 2774, 1956, 11260, 16, 17622, 16, 1930, 2233, 3784, 3947, 2603, 2256, 20463, 3181, 18, 14393, 6874, 1968, 3]}, "items": [{"id": "p_283", "content": "Ascites [SEP] Accumulation or retention of free fluid within the peritoneal cavity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17622, 3, 4858, 2014, 7521, 1927, 3294, 5466, 2651, 1920, 10706, 8568, 18, 3]}]}
{"query": {"id": "q_284", "content": "cor pulmonale [SEP] ure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal functio", "tokenized_content": [2, 2233, 3784, 3947, 2603, 3, 6794, 1956, 4194, 7640, 1952, 6026, 1922, 43, 2774, 1956, 11260, 16, 17622, 16, 1930, 2233, 3784, 3947, 2603, 2256, 20463, 3181, 18, 14393, 12010, 3]}, "items": [{"id": "p_284", "content": "Pulmonary Heart Disease [SEP] Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often a", "score": 1, "type": null, "tokenized_content": [2, 5352, 4003, 2573, 3, 11014, 1930, 16470, 1927, 1920, 3659, 11887, 1927, 1920, 4003, 1988, 1977, 4189, 2007, 5352, 5579, 18, 2052, 2625, 1977, 3868, 43, 3]}]}
{"query": {"id": "q_285", "content": "indomethacin [SEP] a in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug wit", "tokenized_content": [2, 20463, 3, 43, 1922, 43, 2774, 1956, 11260, 16, 17622, 16, 1930, 2233, 3784, 3947, 2603, 2256, 20463, 3181, 18, 14393, 12010, 1927, 4604, 2347, 3489, 2838, 16086, 3]}, "items": [{"id": "p_285", "content": "Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla", "score": 1, "type": null, "tokenized_content": [2, 20463, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 7042, 1920, 4113, 21271, 4680, 1958, 1920, 3337, 1927, 4876, 15915, 1019, 3]}]}
{"query": {"id": "q_286", "content": "oliguria [SEP] ngle dose of indomethacin caused recurrence of acute reversible oliguria. Our case supports the hypothesis that endogenous renal prostag", "tokenized_content": [2, 4833, 8754, 3, 4375, 1952, 3253, 1927, 20463, 4189, 6339, 1927, 3939, 10743, 4833, 8754, 18, 2342, 3087, 7825, 1920, 4676, 1988, 5355, 4604, 4876, 2006, 3]}, "items": [{"id": "p_286", "content": "Oliguria [SEP] Decreased URINE output that is below the normal range. Oliguria can be defined as urine output of less than or equal to 0.5 or 1", "score": 1, "type": null, "tokenized_content": [2, 4833, 8754, 3, 3261, 6960, 6647, 1988, 1977, 4535, 1920, 2791, 3109, 18, 4833, 8754, 2112, 1998, 3608, 1966, 6960, 6647, 1927, 2941, 2254, 2014, 5557, 1942, 20, 18, 25, 2014, 21, 3]}]}
{"query": {"id": "q_287", "content": "prostaglandins [SEP] liguria. Our case supports the hypothesis that endogenous renal prostaglandins play a role in the maintenance of renal blood flow when circula", "tokenized_content": [2, 25674, 3, 3650, 8754, 18, 2342, 3087, 7825, 1920, 4676, 1988, 5355, 4604, 25674, 3918, 43, 2770, 1922, 1920, 6291, 1927, 4604, 2877, 3426, 2469, 3624, 5617, 3]}, "items": [{"id": "p_287", "content": "Prostaglandins [SEP] A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway.", "score": 1, "type": null, "tokenized_content": [2, 25674, 3, 43, 2210, 1927, 4300, 3595, 2037, 19172, 2036, 17, 5056, 5934, 4576, 16, 5985, 19571, 2687, 16, 3454, 1920, 21271, 3374, 18, 3]}]}
{"query": {"id": "q_288", "content": "acute renal failure [SEP] agents interfere with this compensatory mechanism and may cause acute renal failure, they should be used with caution in such patients.", "tokenized_content": [2, 3939, 4604, 4574, 3, 4820, 11827, 1956, 2052, 13447, 2856, 1930, 2278, 3936, 3939, 4604, 4574, 16, 2611, 3066, 1998, 2251, 1956, 12838, 1922, 2427, 2132, 18, 3]}, "items": [{"id": "p_288", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_289", "content": "flunitrazepam [SEP] plasma concentrations following oral and i.m. administration of flunitrazepam in volunteers.", "tokenized_content": [2, 2848, 8635, 10261, 6931, 4302, 1035, 3, 3582, 3295, 2894, 4726, 1930, 51, 18, 55, 18, 4183, 1927, 2848, 8635, 10261, 6931, 4302, 1035, 1922, 9701, 18, 3]}, "items": [{"id": "p_289", "content": "Flunitrazepam [SEP] A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indica", "score": 1, "type": null, "tokenized_content": [2, 2848, 8635, 10261, 6931, 4302, 1035, 3, 43, 27266, 1956, 17225, 7728, 2551, 1942, 2690, 1927, 26079, 1988, 2112, 3936, 26680, 14701, 7156, 18, 2673, 4710, 29338, 3]}]}
{"query": {"id": "q_290", "content": "Flunitrazepam [SEP] Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to grou", "tokenized_content": [2, 2848, 8635, 10261, 6931, 4302, 1035, 3, 2848, 8635, 10261, 6931, 4302, 1035, 20, 18, 25, 16, 21, 18, 20, 2014, 22, 18, 20, 2786, 1982, 3258, 2007, 1920, 4726, 3]}, "items": [{"id": "p_290", "content": "Flunitrazepam [SEP] A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indica", "score": 1, "type": null, "tokenized_content": [2, 2848, 8635, 10261, 6931, 4302, 1035, 3, 43, 27266, 1956, 17225, 7728, 2551, 1942, 2690, 1927, 26079, 1988, 2112, 3936, 26680, 14701, 7156, 18, 2673, 4710, 29338, 3]}]}
{"query": {"id": "q_291", "content": "Dizziness [SEP] metimes lasted longer than those following oral administration. Dizziness was less marked than sedation, but increased with the dose. The", "tokenized_content": [2, 24009, 3, 2130, 11593, 1036, 16276, 4872, 2254, 2690, 2894, 4726, 4183, 18, 24009, 1982, 2941, 4961, 2254, 15263, 16, 2308, 2502, 1956, 1920, 3253, 18, 1920, 3]}, "items": [{"id": "p_291", "content": "Dizziness [SEP] An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24009, 3, 1925, 26385, 2870, 2576, 2154, 2278, 3333, 1942, 43, 7534, 1927, 5067, 2054, 29292, 16, 6269, 1927, 1920, 3515, 16, 2014, 3696, 10611, 1919, 2971, 18, 3]}]}
{"query": {"id": "q_292", "content": "pain [SEP] ss marked than sedation, but increased with the dose. There was pain on i.m. injection of flunitrazepam significantly more often tha", "tokenized_content": [2, 3594, 3, 4577, 4961, 2254, 15263, 16, 2308, 2502, 1956, 1920, 3253, 18, 2276, 1982, 3594, 1990, 51, 18, 55, 18, 4107, 1927, 2848, 8635, 10261, 6931, 4302, 1035, 2567, 3]}, "items": [{"id": "p_292", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_293", "content": "flunitrazepam [SEP] ut increased with the dose. There was pain on i.m. injection of flunitrazepam significantly more often than with isotonic saline. Plasma conc", "tokenized_content": [2, 2848, 8635, 10261, 6931, 4302, 1035, 3, 11112, 2502, 1956, 1920, 3253, 18, 2276, 1982, 3594, 1990, 51, 18, 55, 18, 4107, 1927, 2848, 8635, 10261, 6931, 4302, 1035, 2567, 3]}, "items": [{"id": "p_293", "content": "Flunitrazepam [SEP] A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indica", "score": 1, "type": null, "tokenized_content": [2, 2848, 8635, 10261, 6931, 4302, 1035, 3, 43, 27266, 1956, 17225, 7728, 2551, 1942, 2690, 1927, 26079, 1988, 2112, 3936, 26680, 14701, 7156, 18, 2673, 4710, 29338, 3]}]}
{"query": {"id": "q_294", "content": "timolol [SEP] Changes in heart size during long-term timolol treatment after myocardial infarction.", "tokenized_content": [2, 2267, 23646, 3, 2840, 1922, 4003, 3081, 2409, 2815, 17, 2576, 2267, 23646, 2311, 2256, 6497, 8358, 18, 3]}, "items": [{"id": "p_294", "content": "Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as ", "score": 1, "type": null, "tokenized_content": [2, 2267, 23646, 3, 43, 4666, 17, 13672, 8151, 2551, 1922, 4615, 1942, 21395, 18, 1920, 30129, 17, 15348, 1977, 1920, 2253, 3500, 18, 2267, 23646, 2258, 2252, 4211, 1966, 3]}]}
{"query": {"id": "q_295", "content": "myocardial infarction [SEP] Changes in heart size during long-term timolol treatment after myocardial infarction.", "tokenized_content": [2, 6497, 8358, 3, 2840, 1922, 4003, 3081, 2409, 2815, 17, 2576, 2267, 23646, 2311, 2256, 6497, 8358, 18, 3]}, "items": [{"id": "p_295", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_296", "content": "timolol [SEP] The effect of long-term timolol treatment on heart size after myocardial infarction was evaluat", "tokenized_content": [2, 2267, 23646, 3, 1920, 2495, 1927, 2815, 17, 2576, 2267, 23646, 2311, 1990, 4003, 3081, 2256, 6497, 8358, 1982, 2711, 1926, 3]}, "items": [{"id": "p_296", "content": "Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as ", "score": 1, "type": null, "tokenized_content": [2, 2267, 23646, 3, 43, 4666, 17, 13672, 8151, 2551, 1922, 4615, 1942, 21395, 18, 1920, 30129, 17, 15348, 1977, 1920, 2253, 3500, 18, 2267, 23646, 2258, 2252, 4211, 1966, 3]}]}
{"query": {"id": "q_297", "content": "myocardial infarction [SEP] The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 pa", "tokenized_content": [2, 6497, 8358, 3, 1920, 2495, 1927, 2815, 17, 2576, 2267, 23646, 2311, 1990, 4003, 3081, 2256, 6497, 8358, 1982, 3747, 2007, 66, 17, 6451, 1922, 43, 4825, 17, 7109, 2161, 3]}, "items": [{"id": "p_297", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_298", "content": "bradycardia [SEP] acebo group. These differences may be caused by timolol-induced bradycardia and a compensatory increase in end-diastolic volume. The timolo", "tokenized_content": [2, 26192, 3, 8298, 4627, 2210, 18, 2144, 2886, 2278, 1998, 4189, 2007, 2267, 23646, 17, 2719, 26192, 1930, 43, 13447, 2760, 1922, 2482, 17, 9395, 3776, 18, 1920, 2267, 26356, 3]}, "items": [{"id": "p_298", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_299", "content": "cardiomegaly [SEP] atients with normal and borderline heart size. In patients with cardiomegaly, the increase in heart size was similar in both groups. After r", "tokenized_content": [2, 21129, 3870, 5411, 1012, 3, 2019, 6746, 1956, 2791, 1930, 16242, 4003, 3081, 18, 1922, 2132, 1956, 21129, 3870, 5411, 1012, 16, 1920, 2760, 1922, 4003, 3081, 1982, 2551, 1922, 3]}, "items": [{"id": "p_299", "content": "Cardiomegaly [SEP] Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the l", "score": 1, "type": null, "tokenized_content": [2, 21129, 3870, 5411, 1012, 3, 16363, 1927, 1920, 4003, 16, 5394, 3391, 2007, 43, 21129, 1963, 18871, 3400, 3538, 20, 18, 2761, 18, 4003, 16363, 2278, 8156, 1920, 3659, 16, 1920, 54, 3]}]}
{"query": {"id": "q_300", "content": "infarction [SEP] t of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 pa", "tokenized_content": [2, 8358, 3, 62, 1927, 2815, 17, 2576, 2267, 23646, 2311, 1990, 4003, 3081, 2256, 6497, 8358, 1982, 3747, 2007, 66, 17, 6451, 1922, 43, 4825, 17, 7109, 2161, 2710, 21616, 3]}, "items": [{"id": "p_300", "content": "Infarction [SEP] Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most", "score": 1, "type": null, "tokenized_content": [2, 8358, 3, 3337, 1927, 1925, 13389, 16, 2154, 1977, 7476, 1922, 2960, 2810, 1942, 3076, 7716, 3864, 2037, 10849, 1927, 2877, 9255, 16, 2501, 3]}]}
{"query": {"id": "q_301", "content": "Vitamin D3 [SEP] Vitamin D3 toxicity in dairy cows.", "tokenized_content": [2, 6111, 11319, 3, 6111, 11319, 5532, 1922, 14397, 14202, 18, 3]}, "items": [{"id": "p_301", "content": "Cholecalciferol [SEP] Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in h", "score": 1, "type": null, "tokenized_content": [2, 17177, 8515, 3236, 1945, 3, 10533, 1927, 27, 17, 28936, 10465, 22513, 8342, 1945, 5333, 2007, 17077, 16789, 18951, 1927, 1920, 19224, 17, 24523, 5403, 18, 2176, 11457, 2037, 11949, 5000, 3349, 2070, 1945, 1922, 50, 3]}]}
{"query": {"id": "q_302", "content": "toxicity [SEP] Vitamin D3 toxicity in dairy cows.", "tokenized_content": [2, 5532, 3, 6111, 11319, 5532, 1922, 14397, 14202, 18, 3]}, "items": [{"id": "p_302", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_303", "content": "vitamin D3 [SEP] Large parenteral doses of vitamin D3 (15 to 17.5 x 10(6) IU vitamin D3) were associated with prolong", "tokenized_content": [2, 6111, 11319, 3, 3103, 20301, 5312, 1927, 6111, 11319, 12, 2461, 1942, 2752, 18, 25, 66, 2119, 12, 26, 13, 11176, 6111, 11319, 13, 1985, 2458, 1956, 6245, 3]}, "items": [{"id": "p_303", "content": "Cholecalciferol [SEP] Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in h", "score": 1, "type": null, "tokenized_content": [2, 17177, 8515, 3236, 1945, 3, 10533, 1927, 27, 17, 28936, 10465, 22513, 8342, 1945, 5333, 2007, 17077, 16789, 18951, 1927, 1920, 19224, 17, 24523, 5403, 18, 2176, 11457, 2037, 11949, 5000, 3349, 2070, 1945, 1922, 50, 3]}]}
{"query": {"id": "q_304", "content": "hypercalcemia [SEP] 5 to 17.5 x 10(6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its m", "tokenized_content": [2, 25374, 9358, 3, 25, 1942, 2752, 18, 25, 66, 2119, 12, 26, 13, 11176, 6111, 11319, 13, 1985, 2458, 1956, 7171, 25374, 9358, 16, 4194, 25324, 6026, 16, 1930, 3103, 3]}, "items": [{"id": "p_304", "content": "Hypercalcemia [SEP] Abnormally high level of calcium in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25374, 9358, 3, 20756, 2149, 2237, 1927, 5016, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_305", "content": "hyperphosphatemia [SEP] 6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its metabolites in the b", "tokenized_content": [2, 4194, 25324, 6026, 3, 26, 13, 11176, 6111, 11319, 13, 1985, 2458, 1956, 7171, 25374, 9358, 16, 4194, 25324, 6026, 16, 1930, 3103, 4041, 1927, 6111, 11319, 1930, 2496, 6926, 3]}, "items": [{"id": "p_305", "content": "Hyperphosphatemia [SEP] A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol ", "score": 1, "type": null, "tokenized_content": [2, 4194, 25324, 6026, 3, 43, 2625, 1927, 20756, 2149, 2237, 1927, 26473, 1922, 1920, 2877, 16, 5394, 2567, 3538, 1920, 2791, 3109, 1927, 20, 18, 5686, 17, 21, 18, 4804, 6397, 3]}]}
{"query": {"id": "q_306", "content": "Calcium [SEP] od plasma of nonlactating nonpregnant and pregnant Jersey cows. Calcium concentrations 1 day postpartum were higher in cows treated wit", "tokenized_content": [2, 5016, 3, 4426, 3582, 1927, 2447, 5148, 2341, 2287, 24857, 17473, 2031, 1930, 7808, 28468, 14202, 18, 5016, 3295, 21, 3007, 13171, 1985, 2580, 1922, 14202, 2868, 16086, 3]}, "items": [{"id": "p_306", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_307", "content": "milk fever [SEP] 0 ml). None of the cows treated with vitamin D3 showed signs of milk fever during the peripartal period; however, 22% of the control cows ", "tokenized_content": [2, 7126, 9087, 3, 20, 2646, 13, 18, 6046, 1927, 1920, 14202, 2868, 1956, 6111, 11319, 2594, 6879, 1927, 7126, 9087, 2409, 1920, 4610, 5263, 1923, 3047, 31, 2406, 16, 2950, 3]}, "items": [{"id": "p_307", "content": "Parturient Paresis [SEP] A disease of pregnant and lactating cows and ewes leading to generalized paresis and death. The disease, which is characterized ", "score": 1, "type": null, "tokenized_content": [2, 3131, 18330, 1939, 2096, 2600, 3, 43, 2573, 1927, 7808, 1930, 25984, 14202, 1930, 28127, 4523, 1942, 9612, 2096, 2600, 1930, 3539, 18, 1920, 2573, 16, 2154, 1977, 4378, 3]}]}
{"query": {"id": "q_308", "content": "toxicity [SEP] cal signs of milk fever during this period. Signs of vitamin D3 toxicity were not observed in nonlactating nonpregnant cows; however, pr", "tokenized_content": [2, 5532, 3, 2570, 6879, 1927, 7126, 9087, 2409, 2052, 3047, 18, 6879, 1927, 6111, 11319, 5532, 1985, 2084, 2528, 1922, 2447, 5148, 2341, 2287, 24857, 17473, 2031, 14202, 31, 2406, 3]}, "items": [{"id": "p_308", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_309", "content": "Diseases of peripheral nerves [SEP] Diseases of peripheral nerves as seen in the Nigerian African.", "tokenized_content": [2, 3902, 1927, 5009, 12014, 3, 3902, 1927, 5009, 12014, 1966, 3945, 1922, 1920, 17328, 1022, 7050, 18, 3]}, "items": [{"id": "p_309", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_310", "content": "peripheral nerve disease [SEP] The anatomical and aetiological diagnoses of peripheral nerve disease excluding its primary benign and malignant disorders, as seen i", "tokenized_content": [2, 5009, 5507, 2573, 3, 1920, 8996, 1930, 18822, 2477, 9455, 1927, 5009, 5507, 2573, 10566, 2496, 3065, 8867, 1930, 6558, 4414, 16, 1966, 3945, 51, 3]}, "items": [{"id": "p_310", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_311", "content": "Sensori-motor neuropathy [SEP] e preponderance and the peak incidence is in the fourth decade. Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr   syndrome ", "tokenized_content": [2, 6443, 1033, 17, 4842, 13177, 3, 47, 10719, 13509, 2152, 1930, 1920, 3833, 4332, 1977, 1922, 1920, 8776, 10468, 18, 6443, 1033, 17, 4842, 13177, 1982, 1920, 29200, 6544, 12, 3]}, "items": [{"id": "p_311", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_312", "content": "Guillain-Barr   syndrome [SEP]  Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr   syndrome was the commonest identifiable cause (15.6%), accounting for ha", "tokenized_content": [2, 22833, 5148, 1921, 17, 18852, 4741, 3, 6443, 1033, 17, 4842, 13177, 1982, 1920, 29200, 6544, 12, 2761, 9, 13, 18, 22833, 5148, 1921, 17, 18852, 4741, 1982, 1920, 29200, 3]}, "items": [{"id": "p_312", "content": "Guillain-Barre Syndrome [SEP] An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin", "score": 1, "type": null, "tokenized_content": [2, 22833, 5148, 1921, 17, 19423, 4741, 3, 1925, 3939, 3769, 8904, 2974, 3678, 4189, 2007, 62, 2024, 17, 3434, 3689, 3743, 2644, 6554, 5681, 5009, 12996, 3]}]}
{"query": {"id": "q_313", "content": "motor neuropathy [SEP] derance and the peak incidence is in the fourth decade. Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr   syndrome ", "tokenized_content": [2, 4842, 13177, 3, 3135, 2152, 1930, 1920, 3833, 4332, 1977, 1922, 1920, 8776, 10468, 18, 6443, 1033, 17, 4842, 13177, 1982, 1920, 29200, 6544, 12, 2761, 9, 13, 18, 22833, 3]}, "items": [{"id": "p_313", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_314", "content": "Peripheral neuropathy [SEP] 15.6%), accounting for half of the cases with motor neuropathy. Peripheral neuropathy due to nutritional deficiency of thiamine and riboflavin was co", "tokenized_content": [2, 5009, 13177, 3, 2461, 18, 26, 9, 13, 16, 10919, 1958, 4768, 1927, 1920, 2919, 1956, 4842, 13177, 18, 5009, 13177, 2810, 1942, 9369, 6179, 1927, 26901, 1930, 28849, 1982, 3]}, "items": [{"id": "p_314", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_315", "content": "nutritional deficiency [SEP] f the cases with motor neuropathy. Peripheral neuropathy due to nutritional deficiency of thiamine and riboflavin was common (10.1%) and presented mai", "tokenized_content": [2, 9369, 6179, 3, 48, 1920, 2919, 1956, 4842, 13177, 18, 5009, 13177, 2810, 1942, 9369, 6179, 1927, 26901, 1930, 28849, 1982, 3059, 12, 2119, 18, 21, 9, 13, 1930, 3549, 3]}, "items": [{"id": "p_315", "content": "Malnutrition [SEP] An imbalanced nutritional status resulted from insufficient intake of nutrients to meet normal physiological requirement.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16823, 3, 1925, 14093, 1007, 9369, 3642, 4306, 2037, 9406, 5240, 1927, 11312, 1942, 9572, 2791, 5005, 8853, 18, 3]}]}
{"query": {"id": "q_316", "content": "thiamine [SEP] ropathy. Peripheral neuropathy due to nutritional deficiency of thiamine and riboflavin was common (10.1%) and presented mainly as senso", "tokenized_content": [2, 26901, 3, 17890, 15935, 18, 5009, 13177, 2810, 1942, 9369, 6179, 1927, 26901, 1930, 28849, 1982, 3059, 12, 2119, 18, 21, 9, 13, 1930, 3549, 4994, 1966, 2658, 1037, 3]}, "items": [{"id": "p_316", "content": "Thiamine [SEP] 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26901, 3, 23, 17, 12, 12, 24, 17, 3835, 17, 22, 17, 4963, 17, 25, 17, 17015, 7650, 2199, 13, 4963, 13, 17, 25, 17, 12, 22, 17, 8275, 5188, 13, 17, 24, 17, 4963, 28042, 2457, 9140, 18, 3]}]}
{"query": {"id": "q_317", "content": "riboflavin [SEP] pheral neuropathy due to nutritional deficiency of thiamine and riboflavin was common (10.1%) and presented mainly as sensory and sensori-", "tokenized_content": [2, 28849, 3, 18363, 1923, 13177, 2810, 1942, 9369, 6179, 1927, 26901, 1930, 28849, 1982, 3059, 12, 2119, 18, 21, 9, 13, 1930, 3549, 4994, 1966, 6893, 1930, 6443, 1033, 17, 3]}, "items": [{"id": "p_317", "content": "Riboflavin [SEP] Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is", "score": 1, "type": null, "tokenized_content": [2, 28849, 3, 9369, 2991, 2435, 1922, 7126, 16, 10567, 16, 15505, 1919, 18779, 16, 3568, 16, 5245, 16, 4003, 16, 1930, 6998, 1012, 14206, 18, 1920, 5536, 2158, 4613, 4585, 1977, 3]}]}
{"query": {"id": "q_318", "content": "sensori-motor neuropathy [SEP] boflavin was common (10.1%) and presented mainly as sensory and sensori-motor neuropathy. Diabetes mellitus was the major cause of autonomic neuropathy.", "tokenized_content": [2, 6443, 1033, 17, 4842, 13177, 3, 4078, 23511, 1982, 3059, 12, 2119, 18, 21, 9, 13, 1930, 3549, 4994, 1966, 6893, 1930, 6443, 1033, 17, 4842, 13177, 18, 4032, 9695, 3]}, "items": [{"id": "p_318", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_319", "content": "Diabetes mellitus [SEP] ) and presented mainly as sensory and sensori-motor neuropathy. Diabetes mellitus was the major cause of autonomic neuropathy. Isoniazid was the ", "tokenized_content": [2, 4032, 9695, 3, 13, 1930, 3549, 4994, 1966, 6893, 1930, 6443, 1033, 17, 4842, 13177, 18, 4032, 9695, 1982, 1920, 3044, 3936, 1927, 13725, 13177, 18, 28383, 1982, 1920, 3]}, "items": [{"id": "p_319", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_320", "content": "autonomic neuropathy [SEP] sori-motor neuropathy. Diabetes mellitus was the major cause of autonomic neuropathy. Isoniazid was the most frequent agent in drug-induced neuropat", "tokenized_content": [2, 13725, 13177, 3, 6548, 1033, 17, 4842, 13177, 18, 4032, 9695, 1982, 1920, 3044, 3936, 1927, 13725, 13177, 18, 28383, 1982, 1920, 2501, 6439, 5899, 1922, 2838, 17, 2719, 13889, 3]}, "items": [{"id": "p_320", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_321", "content": "Isoniazid [SEP]  Diabetes mellitus was the major cause of autonomic neuropathy. Isoniazid was the most frequent agent in drug-induced neuropathy. Migrain", "tokenized_content": [2, 28383, 3, 4032, 9695, 1982, 1920, 3044, 3936, 1927, 13725, 13177, 18, 28383, 1982, 1920, 2501, 6439, 5899, 1922, 2838, 17, 2719, 13177, 18, 4119, 2005, 3]}, "items": [{"id": "p_321", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_322", "content": "neuropathy [SEP] e and the peak incidence is in the fourth decade. Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr   syndrome ", "tokenized_content": [2, 13177, 3, 47, 1930, 1920, 3833, 4332, 1977, 1922, 1920, 8776, 10468, 18, 6443, 1033, 17, 4842, 13177, 1982, 1920, 29200, 6544, 12, 2761, 9, 13, 18, 22833, 5148, 1921, 3]}, "items": [{"id": "p_322", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_323", "content": "Migraine [SEP] oniazid was the most frequent agent in drug-induced neuropathy. Migraine (20%) was not an uncommon cause of cranial neuropathy although ", "tokenized_content": [2, 13258, 3, 1990, 7736, 1960, 1982, 1920, 2501, 6439, 5899, 1922, 2838, 17, 2719, 13177, 18, 13258, 12, 2036, 9, 13, 1982, 2084, 1925, 14403, 3936, 1927, 13598, 13177, 2876, 3]}, "items": [{"id": "p_323", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_324", "content": "cranial neuropathy [SEP] induced neuropathy. Migraine (20%) was not an uncommon cause of cranial neuropathy although malignancies arising from the reticuloendothelial syst", "tokenized_content": [2, 13598, 13177, 3, 2719, 13177, 18, 13258, 12, 2036, 9, 13, 1982, 2084, 1925, 14403, 3936, 1927, 13598, 13177, 2876, 10672, 11894, 2037, 1920, 18905, 6802, 10249, 2195, 3583, 8055, 3]}, "items": [{"id": "p_324", "content": "Cranial Nerve Diseases [SEP] Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disor", "score": 1, "type": null, "tokenized_content": [2, 13598, 5507, 3902, 3, 4414, 1927, 2340, 2014, 2253, 1927, 1920, 12367, 13598, 12014, 18, 1956, 1920, 7541, 1927, 1920, 10109, 1930, 11284, 12014, 16, 2052, 5921, 2054, 1924, 3]}]}
{"query": {"id": "q_325", "content": "malignancies [SEP]  (20%) was not an uncommon cause of cranial neuropathy although malignancies arising from the reticuloendothelial system or related structur", "tokenized_content": [2, 10672, 3, 12, 2036, 9, 13, 1982, 2084, 1925, 14403, 3936, 1927, 13598, 13177, 2876, 10672, 11894, 2037, 1920, 18905, 6802, 10249, 2195, 3583, 2433, 2014, 2712, 2581, 1949, 3]}, "items": [{"id": "p_325", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_326", "content": "connective tissue disorders [SEP] etiology of the neuropathy was undetermined. Heredofamilial and connective tissue disorders were rare. Some of the factors related to the clinical presenta", "tokenized_content": [2, 14948, 2960, 4414, 3, 10383, 1927, 1920, 13177, 1982, 27115, 18, 15429, 4199, 23767, 1923, 1930, 14948, 2960, 4414, 1985, 5844, 18, 2673, 1927, 1920, 2790, 2712, 1942, 1920, 2535, 3]}, "items": [{"id": "p_326", "content": "Connective Tissue Diseases [SEP] A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or ", "score": 1, "type": null, "tokenized_content": [2, 14948, 2960, 3902, 3, 43, 8538, 2210, 1927, 4414, 16, 2673, 16321, 16, 4991, 5815, 16, 4378, 2007, 4552, 3170, 2014, 2347, 1927, 2340, 2014, 3]}]}
{"query": {"id": "q_327", "content": "neuropathies [SEP] rs related to the clinical presentation and pathogenesis of the neuropathies are briefly discussed.", "tokenized_content": [2, 8798, 2062, 3, 4366, 2712, 1942, 1920, 2535, 6544, 1930, 6559, 1927, 1920, 8798, 2062, 2032, 6699, 5601, 18, 3]}, "items": [{"id": "p_327", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_328", "content": "dothiepin hydrochloride [SEP] A double-blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder.", "tokenized_content": [2, 8522, 7969, 2128, 1921, 16675, 3, 43, 4825, 17, 7109, 2161, 1927, 1920, 4348, 1930, 5407, 1927, 8522, 7969, 2128, 1921, 16675, 1922, 1920, 2311, 1927, 3044, 7745, 4770, 18, 3]}, "items": [{"id": "p_328", "content": "Dothiepin [SEP] A tricyclic antidepressant with some tranquilizing action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8522, 7969, 2128, 1921, 3, 43, 12258, 13153, 14183, 1956, 2673, 29808, 2048, 5912, 9046, 4615, 18, 3]}]}
{"query": {"id": "q_329", "content": "depressive disorder [SEP] and safety of dothiepin hydrochloride in the treatment of major depressive disorder.", "tokenized_content": [2, 7745, 4770, 3, 1930, 5407, 1927, 8522, 7969, 2128, 1921, 16675, 1922, 1920, 2311, 1927, 3044, 7745, 4770, 18, 3]}, "items": [{"id": "p_329", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_330", "content": "dothiepin [SEP] In a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of ", "tokenized_content": [2, 8522, 7969, 2128, 1921, 3, 1922, 43, 26, 17, 2982, 4825, 17, 7109, 6110, 2311, 2161, 16, 8522, 7969, 2128, 1921, 1930, 15665, 1997, 14302, 26561, 1985, 2452, 1942, 5936, 3]}, "items": [{"id": "p_330", "content": "Dothiepin [SEP] A tricyclic antidepressant with some tranquilizing action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8522, 7969, 2128, 1921, 3, 43, 12258, 13153, 14183, 1956, 2673, 29808, 2048, 5912, 9046, 4615, 18, 3]}]}
{"query": {"id": "q_331", "content": "amitriptyline [SEP] n a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpa", "tokenized_content": [2, 15665, 1997, 14302, 26561, 3, 56, 43, 26, 17, 2982, 4825, 17, 7109, 6110, 2311, 2161, 16, 8522, 7969, 2128, 1921, 1930, 15665, 1997, 14302, 26561, 1985, 2452, 1942, 5936, 3]}, "items": [{"id": "p_331", "content": "Amitriptyline [SEP] Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and", "score": 1, "type": null, "tokenized_content": [2, 15665, 1997, 14302, 26561, 3, 12258, 13153, 14183, 1956, 5851, 12074, 12745, 1930, 28514, 3879, 18, 2176, 5107, 1942, 4625, 1920, 1964, 17, 5047, 1927, 16436, 1930, 3]}]}
{"query": {"id": "q_332", "content": "depressed [SEP] d amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effective", "tokenized_content": [2, 11365, 3, 46, 15665, 1997, 14302, 26561, 1985, 2452, 1942, 5936, 1922, 1920, 2311, 1927, 3401, 11365, 20204, 18, 8522, 7969, 2128, 1921, 1930, 15665, 1997, 14302, 26561, 1985, 9208, 3]}, "items": [{"id": "p_332", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_333", "content": "Dothiepin [SEP] mpared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effective in alleviating the sym", "tokenized_content": [2, 8522, 7969, 2128, 1921, 3, 12888, 3510, 1942, 5936, 1922, 1920, 2311, 1927, 3401, 11365, 20204, 18, 8522, 7969, 2128, 1921, 1930, 15665, 1997, 14302, 26561, 1985, 9208, 3655, 1922, 3]}, "items": [{"id": "p_333", "content": "Dothiepin [SEP] A tricyclic antidepressant with some tranquilizing action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8522, 7969, 2128, 1921, 3, 43, 12258, 13153, 14183, 1956, 2673, 29808, 2048, 5912, 9046, 4615, 18, 3]}]}
{"query": {"id": "q_334", "content": "depressive illness [SEP] riptyline were equally effective in alleviating the symptoms of depressive illness, and both were significantly superior to placebo. The overall i", "tokenized_content": [2, 7745, 6455, 3, 8936, 3145, 3701, 1985, 9208, 3655, 1922, 12054, 2287, 1920, 3601, 1927, 7745, 6455, 16, 1930, 2321, 1985, 2567, 6566, 1942, 5936, 18, 1920, 3399, 51, 3]}, "items": [{"id": "p_334", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_335", "content": "blurred vision [SEP] all incidence of side effects and the frequency and severity of blurred vision, dry mouth, and drowsiness were significantly less with dothiep", "tokenized_content": [2, 2266, 19294, 9266, 3, 2136, 4332, 1927, 4159, 2564, 1930, 1920, 3528, 1930, 5155, 1927, 2266, 19294, 9266, 16, 7143, 11701, 16, 1930, 29247, 6777, 1979, 1985, 2567, 2941, 1956, 3]}, "items": [{"id": "p_335", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_336", "content": "dry mouth [SEP]  side effects and the frequency and severity of blurred vision, dry mouth, and drowsiness were significantly less with dothiepin than wit", "tokenized_content": [2, 7143, 11701, 3, 4159, 2564, 1930, 1920, 3528, 1930, 5155, 1927, 2266, 19294, 9266, 16, 7143, 11701, 16, 1930, 29247, 6777, 1979, 1985, 2567, 2941, 1956, 8522, 7969, 2128, 1921, 3]}, "items": [{"id": "p_336", "content": "Xerostomia [SEP] Decreased salivary flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27833, 28009, 2126, 3, 3261, 11866, 3426, 18, 3]}]}
{"query": {"id": "q_337", "content": "antidepressant [SEP] oratory parameters. Dothiepin thus was found to be an effective antidepressant drug associated with fewer side effects than amitriptyline in t", "tokenized_content": [2, 14183, 3, 2014, 2548, 3673, 18, 8522, 7969, 2128, 1921, 2842, 1982, 2435, 1942, 1998, 1925, 3655, 14183, 2838, 2458, 1956, 7380, 4159, 2564, 2254, 15665, 1997, 14302, 26561, 1922, 3]}, "items": [{"id": "p_337", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_338", "content": "diazepam [SEP] Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia", "tokenized_content": [2, 26079, 3, 5343, 2564, 1927, 26079, 1930, 21395, 1922, 2132, 1956, 21820, 4770, 1930, 11511, 5524, 2102, 18311, 3]}, "items": [{"id": "p_338", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_339", "content": "propranolol [SEP] Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia.", "tokenized_content": [2, 21395, 3, 5343, 2564, 1927, 26079, 1930, 21395, 1922, 2132, 1956, 21820, 4770, 1930, 11511, 5524, 2102, 18311, 18, 3]}, "items": [{"id": "p_339", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_340", "content": "panic disorder [SEP] Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia.", "tokenized_content": [2, 21820, 4770, 3, 5343, 2564, 1927, 26079, 1930, 21395, 1922, 2132, 1956, 21820, 4770, 1930, 11511, 5524, 2102, 18311, 18, 3]}, "items": [{"id": "p_340", "content": "Panic Disorder [SEP] A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin wi", "score": 1, "type": null, "tokenized_content": [2, 21820, 4770, 3, 43, 2601, 1927, 5592, 4770, 4378, 2007, 9892, 21820, 15413, 1988, 4691, 4814, 2014, 16, 9671, 16, 3967, 18, 21820, 15413, 11763, 11980, 3]}]}
{"query": {"id": "q_341", "content": "agoraphobia [SEP] of diazepam and propranolol in patients with panic disorder and agoraphobia.", "tokenized_content": [2, 11511, 5524, 2102, 18311, 3, 1927, 26079, 1930, 21395, 1922, 2132, 1956, 21820, 4770, 1930, 11511, 5524, 2102, 18311, 18, 3]}, "items": [{"id": "p_341", "content": "Agoraphobia [SEP] Obsessive, persistent, intense fear of open places.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11511, 5524, 2102, 18311, 3, 25555, 16, 7733, 16, 10702, 8196, 1927, 4437, 14412, 18, 3]}]}
{"query": {"id": "q_342", "content": "diazepam [SEP] The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg/day for 2 week", "tokenized_content": [2, 26079, 3, 1920, 2564, 1927, 4726, 5312, 1927, 26079, 12, 2957, 3253, 1927, 2119, 2786, 1930, 43, 4181, 3253, 1927, 2627, 2786, 19, 3007, 1958, 22, 2982, 3]}, "items": [{"id": "p_342", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_343", "content": "propranolol [SEP] e dose of 10 mg and a median dose of 30 mg/day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg/day for 2 wee", "tokenized_content": [2, 21395, 3, 47, 3253, 1927, 2119, 2786, 1930, 43, 4181, 3253, 1927, 2627, 2786, 19, 3007, 1958, 22, 3625, 13, 1930, 21395, 12, 2957, 3253, 1927, 3729, 2786, 1930, 43, 3]}, "items": [{"id": "p_343", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_344", "content": "panic disorders [SEP] /day for 2 weeks) on psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized", "tokenized_content": [2, 21820, 4414, 3, 19, 3007, 1958, 22, 3625, 13, 1990, 6674, 3604, 1927, 2132, 1956, 21820, 4414, 1930, 11511, 5524, 2102, 18311, 1985, 3845, 1922, 43, 4825, 17, 7109, 16, 3]}, "items": [{"id": "p_344", "content": "Panic Disorder [SEP] A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin wi", "score": 1, "type": null, "tokenized_content": [2, 21820, 4770, 3, 43, 2601, 1927, 5592, 4770, 4378, 2007, 9892, 21820, 15413, 1988, 4691, 4814, 2014, 16, 9671, 16, 3967, 18, 21820, 15413, 11763, 11980, 3]}]}
{"query": {"id": "q_345", "content": "agoraphobia [SEP]  psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized and crossover d", "tokenized_content": [2, 11511, 5524, 2102, 18311, 3, 6674, 3604, 1927, 2132, 1956, 21820, 4414, 1930, 11511, 5524, 2102, 18311, 1985, 3845, 1922, 43, 4825, 17, 7109, 16, 5542, 1930, 15845, 46, 3]}, "items": [{"id": "p_345", "content": "Agoraphobia [SEP] Obsessive, persistent, intense fear of open places.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11511, 5524, 2102, 18311, 3, 25555, 16, 7733, 16, 10702, 8196, 1927, 4437, 14412, 18, 3]}]}
{"query": {"id": "q_346", "content": "impaired immediate free recall [SEP]  in a double-blind, randomized and crossover design. Both drugs impaired immediate free recall but the decrease was greater for diazepam than propranolol. Del", "tokenized_content": [2, 5761, 8426, 3294, 8717, 3, 1922, 43, 4825, 17, 7109, 16, 5542, 1930, 15845, 3036, 18, 2321, 4195, 5761, 8426, 3294, 8717, 2308, 1920, 3714, 1982, 3430, 1958, 26079, 2254, 3]}, "items": [{"id": "p_346", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_347", "content": "Delayed free recall was also impaired [SEP] all but the decrease was greater for diazepam than propranolol. Delayed free recall was also impaired but the two drugs did not differ. Patients tapped faster after ", "tokenized_content": [2, 7083, 3294, 8717, 1982, 2222, 5761, 3, 2136, 2308, 1920, 3714, 1982, 3430, 1958, 26079, 2254, 21395, 18, 7083, 3294, 8717, 1982, 2222, 5761, 2308, 1920, 2288, 4195, 2811, 2084, 3]}, "items": [{"id": "p_347", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_348", "content": "behavioral impairment [SEP]  subjects. Accumulation of drugs was not reflected in prolonged behavioral impairment.", "tokenized_content": [2, 5343, 6159, 3, 3297, 18, 4858, 1927, 4195, 1982, 2084, 8830, 1922, 7171, 5343, 6159, 18, 3]}, "items": [{"id": "p_348", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_349", "content": "aspirin [SEP] Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithe", "tokenized_content": [2, 12396, 3, 2495, 1927, 12396, 1990, 56, 17, 37, 24, 17, 12, 25, 17, 8686, 17, 22, 17, 2498, 2199, 13, 17, 22, 17, 27225, 26558, 1024, 39, 17, 2386, 3]}, "items": [{"id": "p_349", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_350", "content": "N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide [SEP] Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and for", "tokenized_content": [2, 56, 17, 37, 24, 17, 12, 25, 17, 8686, 17, 22, 17, 2498, 2199, 13, 17, 22, 17, 27225, 26558, 1024, 39, 17, 2386, 5482, 3, 2495, 1927, 12396, 1990, 3]}, "items": [{"id": "p_350", "content": "FANFT [SEP] A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteri", "score": 1, "type": null, "tokenized_content": [2, 19764, 2794, 3, 43, 6828, 8686, 29579, 10533, 2798, 23467, 18, 2176, 5092, 7821, 3861, 1922, 2136, 3555, 3942, 1930, 1977, 21977, 1942, 3086, 14027, 3]}]}
{"query": {"id": "q_351", "content": "aspirin [SEP] The co-administration of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to r", "tokenized_content": [2, 12396, 3, 1920, 2081, 17, 4183, 1927, 12396, 1956, 56, 17, 37, 24, 17, 12, 25, 17, 8686, 17, 22, 17, 2498, 2199, 13, 17, 22, 17, 27225, 26558, 1024, 3]}, "items": [{"id": "p_351", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_352", "content": "N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide [SEP] The co-administration of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to rats resulted in a reduced incidence of FANFT-induce", "tokenized_content": [2, 56, 17, 37, 24, 17, 12, 25, 17, 8686, 17, 22, 17, 2498, 2199, 13, 17, 22, 17, 27225, 26558, 1024, 39, 17, 2386, 5482, 3, 1920, 2081, 17, 4183, 3]}, "items": [{"id": "p_352", "content": "FANFT [SEP] A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteri", "score": 1, "type": null, "tokenized_content": [2, 19764, 2794, 3, 43, 6828, 8686, 29579, 10533, 2798, 23467, 18, 2176, 5092, 7821, 3861, 1922, 2136, 3555, 3942, 1930, 1977, 21977, 1942, 3086, 14027, 3]}]}
{"query": {"id": "q_353", "content": "FANFT [SEP]  of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to rats resulted in a reduced incidence of FANFT-induced bladd", "tokenized_content": [2, 19764, 2794, 3, 1927, 12396, 1956, 56, 17, 37, 24, 17, 12, 25, 17, 8686, 17, 22, 17, 2498, 2199, 13, 17, 22, 17, 27225, 26558, 1024, 39, 17, 2386, 3]}, "items": [{"id": "p_353", "content": "FANFT [SEP] A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteri", "score": 1, "type": null, "tokenized_content": [2, 19764, 2794, 3, 43, 6828, 8686, 29579, 10533, 2798, 23467, 18, 2176, 5092, 7821, 3861, 1922, 2136, 3555, 3942, 1930, 1977, 21977, 1942, 3086, 14027, 3]}]}
{"query": {"id": "q_354", "content": "bladder carcinomas [SEP] FANFT) to rats resulted in a reduced incidence of FANFT-induced bladder carcinomas but a concomitant induction of forestomach tumors. An autoradio", "tokenized_content": [2, 7821, 10691, 3, 19764, 2794, 13, 1942, 3615, 4306, 1922, 43, 3028, 4332, 1927, 19764, 2794, 17, 2719, 7821, 10691, 2308, 43, 8537, 4408, 1927, 9238, 29917, 1023, 3861, 18, 3]}, "items": [{"id": "p_354", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_355", "content": "forestomach tumors [SEP] FANFT-induced bladder carcinomas but a concomitant induction of forestomach tumors. An autoradiographic study was performed on male F-344 rats fed", "tokenized_content": [2, 9238, 29917, 1023, 3861, 3, 19764, 2794, 17, 2719, 7821, 10691, 2308, 43, 8537, 4408, 1927, 9238, 29917, 1023, 3861, 18, 1925, 18922, 4158, 2161, 1982, 2593, 1990, 4005, 48, 3]}, "items": [{"id": "p_355", "content": "Stomach Neoplasms [SEP] Tumors or cancer of the STOMACH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11399, 15347, 3, 3861, 2014, 2539, 1927, 1920, 11399, 18, 3]}]}
{"query": {"id": "q_356", "content": "carcinogenesis [SEP] ment suggesting that different mechanisms are involved in FANFT carcinogenesis in the bladder and forestomach, and that aspirin's effect on FA", "tokenized_content": [2, 12559, 3, 11567, 3783, 1988, 2413, 3531, 2032, 3286, 1922, 19764, 2794, 12559, 1922, 1920, 7821, 1930, 9238, 29917, 1023, 16, 1930, 1988, 12396, 11, 61, 2495, 1990, 5685, 3]}, "items": [{"id": "p_356", "content": "Carcinogenesis [SEP] The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between ", "score": 1, "type": null, "tokenized_content": [2, 12559, 3, 1920, 4853, 16, 3372, 2014, 2740, 1927, 2539, 2596, 19251, 1930, 8189, 2840, 2154, 15111, 1946, 1920, 2791, 6766, 2192, 3]}]}
{"query": {"id": "q_357", "content": "hypotension [SEP] Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy?", "tokenized_content": [2, 16453, 3, 2463, 5980, 1927, 17198, 16453, 2007, 8686, 14966, 1921, 1922, 6152, 13725, 13177, 35, 3]}, "items": [{"id": "p_357", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_358", "content": "nitroglycerin [SEP] Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy?", "tokenized_content": [2, 8686, 14966, 1921, 3, 2463, 5980, 1927, 17198, 16453, 2007, 8686, 14966, 1921, 1922, 6152, 13725, 13177, 35, 3]}, "items": [{"id": "p_358", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_359", "content": "diabetic autonomic neuropathy [SEP] Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy?", "tokenized_content": [2, 6152, 13725, 13177, 3, 2463, 5980, 1927, 17198, 16453, 2007, 8686, 14966, 1921, 1922, 6152, 13725, 13177, 35, 3]}, "items": [{"id": "p_359", "content": "Diabetic Neuropathies [SEP] Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result f", "score": 1, "type": null, "tokenized_content": [2, 6152, 8798, 2062, 3, 5009, 16, 13725, 16, 1930, 13598, 5507, 4414, 1988, 2032, 2458, 1956, 4032, 9695, 18, 2144, 2961, 5394, 3211, 48, 3]}]}
{"query": {"id": "q_360", "content": "nitroglycerin [SEP] The effect of nitroglycerin on heart rate and systolic blood pressure was compared in 5 nor", "tokenized_content": [2, 8686, 14966, 1921, 3, 1920, 2495, 1927, 8686, 14966, 1921, 1990, 4003, 2769, 1930, 8541, 2877, 3772, 1982, 2452, 1922, 25, 3990, 3]}, "items": [{"id": "p_360", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_361", "content": "diabetic [SEP] d systolic blood pressure was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects ", "tokenized_content": [2, 6152, 3, 46, 8541, 2877, 3772, 1982, 2452, 1922, 25, 2791, 3297, 16, 2369, 6152, 3297, 2979, 13725, 13177, 16, 1930, 25, 6152, 3297, 3]}, "items": [{"id": "p_361", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_362", "content": "autonomic neuropathy [SEP] was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects with autonomic neuropathy. The magnitu", "tokenized_content": [2, 13725, 13177, 3, 1982, 2452, 1922, 25, 2791, 3297, 16, 2369, 6152, 3297, 2979, 13725, 13177, 16, 1930, 25, 6152, 3297, 1956, 13725, 13177, 18, 1920, 3679, 4219, 3]}, "items": [{"id": "p_362", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_363", "content": "estrogen [SEP] Characterization of estrogen-induced adenohypophyseal tumors in the Fischer 344 rat.", "tokenized_content": [2, 7940, 3, 7285, 1927, 7940, 17, 2719, 29639, 30338, 7056, 25818, 4127, 1923, 3861, 1922, 1920, 20113, 23473, 3067, 18, 3]}, "items": [{"id": "p_363", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_364", "content": "adenohypophyseal tumors [SEP] Characterization of estrogen-induced adenohypophyseal tumors in the Fischer 344 rat.", "tokenized_content": [2, 29639, 30338, 7056, 25818, 4127, 1923, 3861, 3, 7285, 1927, 7940, 17, 2719, 29639, 30338, 7056, 25818, 4127, 1923, 3861, 1922, 1920, 20113, 23473, 3067, 18, 3]}, "items": [{"id": "p_364", "content": "Pituitary Neoplasms [SEP] Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are di", "score": 1, "type": null, "tokenized_content": [2, 10621, 15347, 3, 15347, 2154, 10149, 2037, 2014, 23257, 2606, 1942, 1920, 10621, 8359, 18, 1920, 4827, 1927, 10621, 15347, 2032, 16787, 16, 2154, 2032, 2137, 3]}]}
{"query": {"id": "q_365", "content": "Pituitary tumors [SEP] Pituitary tumors were induced in F344 female rats by chronic treatment with diet", "tokenized_content": [2, 10621, 3861, 3, 10621, 3861, 1985, 2719, 1922, 14499, 6609, 4232, 3615, 2007, 3724, 2311, 1956, 3986, 3]}, "items": [{"id": "p_365", "content": "Pituitary Neoplasms [SEP] Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are di", "score": 1, "type": null, "tokenized_content": [2, 10621, 15347, 3, 15347, 2154, 10149, 2037, 2014, 23257, 2606, 1942, 1920, 10621, 8359, 18, 1920, 4827, 1927, 10621, 15347, 2032, 16787, 16, 2154, 2032, 2137, 3]}]}
{"query": {"id": "q_366", "content": "diethylstilbestrol [SEP] mors were induced in F344 female rats by chronic treatment with diethylstilbestrol (DES, 8-10 mg) implanted subcutaneously in silastic capsules. O", "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 2803, 1036, 1985, 2719, 1922, 14499, 6609, 4232, 3615, 2007, 3724, 2311, 1956, 18622, 2156, 1970, 5873, 2156, 2226, 12, 2270, 16, 28, 3]}, "items": [{"id": "p_366", "content": "Diethylstilbestrol [SEP] A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as", "score": 1, "type": null, "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 43, 6830, 29413, 7940, 2251, 1922, 1920, 2311, 1927, 17779, 1930, 14285, 4414, 18, 2176, 1982, 2222, 2251, 22397, 1966, 3]}]}
{"query": {"id": "q_367", "content": "DES [SEP]  F344 female rats by chronic treatment with diethylstilbestrol (DES, 8-10 mg) implanted subcutaneously in silastic capsules. Over a", "tokenized_content": [2, 2270, 3, 14499, 6609, 4232, 3615, 2007, 3724, 2311, 1956, 18622, 2156, 1970, 5873, 2156, 2226, 12, 2270, 16, 28, 17, 2119, 2786, 13, 10978, 15554, 1922, 4059, 4054, 20206, 3]}, "items": [{"id": "p_367", "content": "Diethylstilbestrol [SEP] A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as", "score": 1, "type": null, "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 43, 6830, 29413, 7940, 2251, 1922, 1920, 2311, 1927, 17779, 1930, 14285, 4414, 18, 2176, 1982, 2222, 2251, 22397, 1966, 3]}]}
{"query": {"id": "q_368", "content": "acriflavine [SEP] d by unit gravity sedimentation, and cell cycle analysis, after acriflavine DNA staining, by laser flow cytometry. Total cell yields from D", "tokenized_content": [2, 10428, 19814, 9188, 2912, 3, 46, 2007, 5344, 18158, 17508, 16, 1930, 2024, 4048, 2333, 16, 2256, 10428, 19814, 9188, 2912, 2678, 4166, 16, 2007, 6033, 3426, 7377, 18, 2698, 3]}, "items": [{"id": "p_368", "content": "Acriflavine [SEP] 3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as ", "score": 1, "type": null, "tokenized_content": [2, 10428, 19814, 9188, 2912, 3, 23, 16, 26, 17, 21121, 1037, 17, 2119, 17, 4963, 6312, 24233, 9140, 3435, 1031, 18, 1956, 23, 16, 26, 17, 10428, 5802, 7408, 3812, 18, 6265, 8347, 2251, 1966, 43, 3076, 8059, 17920, 1930, 2222, 1966, 3]}]}
{"query": {"id": "q_369", "content": "tumor [SEP] Pituitary tumors were induced in F344 female rats by chronic treatment with die", "tokenized_content": [2, 2798, 3, 10621, 3861, 1985, 2719, 1922, 14499, 6609, 4232, 3615, 2007, 3724, 2311, 1956, 8769, 3]}, "items": [{"id": "p_369", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_370", "content": "Triamterene [SEP] Triamterene nephrolithiasis complicating dyazide therapy.", "tokenized_content": [2, 5083, 1976, 1967, 2880, 3, 5083, 1976, 1967, 2880, 7737, 2226, 29016, 6581, 6102, 2104, 6433, 29895, 3181, 18, 3]}, "items": [{"id": "p_370", "content": "Triamterene [SEP] A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5083, 1976, 1967, 2880, 3, 43, 19147, 5802, 1997, 2126, 25157, 3547, 1988, 7042, 5227, 26287, 2596, 5227, 5628, 1922, 4604, 4944, 2094, 18, 3]}]}
{"query": {"id": "q_371", "content": "nephrolithiasis [SEP] Triamterene nephrolithiasis complicating dyazide therapy.", "tokenized_content": [2, 7737, 2226, 29016, 3, 5083, 1976, 1967, 2880, 7737, 2226, 29016, 6581, 6102, 2104, 6433, 29895, 3181, 18, 3]}, "items": [{"id": "p_371", "content": "Nephrolithiasis [SEP] Formation of stones in the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7737, 2226, 29016, 3, 3337, 1927, 18183, 1922, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_372", "content": "dyazide [SEP] Triamterene nephrolithiasis complicating dyazide therapy.", "tokenized_content": [2, 6433, 29895, 3, 5083, 1976, 1967, 2880, 7737, 2226, 29016, 6581, 6102, 2104, 6433, 29895, 3181, 18, 3]}, "items": [{"id": "p_372", "content": "hydrochlorothiazide-triamterene [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14369, 30354, 2261, 17, 5083, 1976, 1967, 2880, 3, 3]}]}
{"query": {"id": "q_373", "content": "triamterene [SEP] A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlo", "tokenized_content": [2, 5083, 1976, 1967, 2880, 3, 43, 3087, 1927, 5083, 1976, 1967, 2880, 7737, 2226, 29016, 1977, 2568, 1922, 43, 2323, 2256, 24, 2739, 1927, 13107, 7806, 1037, 3]}, "items": [{"id": "p_373", "content": "Triamterene [SEP] A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5083, 1976, 1967, 2880, 3, 43, 19147, 5802, 1997, 2126, 25157, 3547, 1988, 7042, 5227, 26287, 2596, 5227, 5628, 1922, 4604, 4944, 2094, 18, 3]}]}
{"query": {"id": "q_374", "content": "nephrolithiasis [SEP] A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide-triam", "tokenized_content": [2, 7737, 2226, 29016, 3, 43, 3087, 1927, 5083, 1976, 1967, 2880, 7737, 2226, 29016, 1977, 2568, 1922, 43, 2323, 2256, 24, 2739, 1927, 14369, 30354, 2261, 17, 5083, 1976, 3]}, "items": [{"id": "p_374", "content": "Nephrolithiasis [SEP] Formation of stones in the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7737, 2226, 29016, 3, 3337, 1927, 18183, 1922, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_375", "content": "hydrochlorothiazide-triamterene [SEP] iamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide-triamterene therapy for hypertension. The stone passed spontaneously and wa", "tokenized_content": [2, 14369, 30354, 2261, 17, 5083, 1976, 1967, 2880, 3, 11640, 8625, 1959, 2912, 7737, 2226, 29016, 1977, 2568, 1922, 43, 2323, 2256, 24, 2739, 1927, 14369, 30354, 2261, 17, 5083, 3]}, "items": [{"id": "p_375", "content": "hydrochlorothiazide-triamterene [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14369, 30354, 2261, 17, 5083, 1976, 1967, 2880, 3, 3]}]}
{"query": {"id": "q_376", "content": "hypertension [SEP] an after 4 years of hydrochlorothiazide-triamterene therapy for hypertension. The stone passed spontaneously and was found to contain a tria", "tokenized_content": [2, 5579, 3, 1925, 2256, 24, 2739, 1927, 14369, 30354, 2261, 17, 5083, 1976, 1967, 2880, 3181, 1958, 5579, 18, 1920, 14595, 12394, 12753, 1930, 1982, 2435, 1942, 5531, 43, 5083, 3]}, "items": [{"id": "p_376", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_377", "content": "adriamycin [SEP] Metabolic involvement in adriamycin cardiotoxicity.", "tokenized_content": [2, 25622, 7898, 3, 4487, 5668, 1922, 25622, 7898, 30490, 18, 3]}, "items": [{"id": "p_377", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_378", "content": "cardiotoxicity [SEP] Metabolic involvement in adriamycin cardiotoxicity.", "tokenized_content": [2, 30490, 3, 4487, 5668, 1922, 25622, 7898, 30490, 18, 3]}, "items": [{"id": "p_378", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_379", "content": "cardiotoxic [SEP] The cardiotoxic effects of adriamycin were studied in mammalian myocardial cell", "tokenized_content": [2, 21129, 4575, 18068, 1030, 3, 1920, 21129, 4575, 18068, 1030, 2564, 1927, 25622, 7898, 1985, 3942, 1922, 6492, 6497, 2024, 3]}, "items": [{"id": "p_379", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_380", "content": "adriamycin [SEP] The cardiotoxic effects of adriamycin were studied in mammalian myocardial cells in culture as a mode", "tokenized_content": [2, 25622, 7898, 3, 1920, 21129, 4575, 18068, 1030, 2564, 1927, 25622, 7898, 1985, 3942, 1922, 6492, 6497, 2094, 1922, 3733, 1966, 43, 5754, 3]}, "items": [{"id": "p_380", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_381", "content": "Adriamycin [SEP] ied in mammalian myocardial cells in culture as a model system. Adriamycin inhibited cell growth and the rhythmic contractions characteris", "tokenized_content": [2, 25622, 7898, 3, 10116, 1007, 1922, 6492, 6497, 2094, 1922, 3733, 1966, 43, 2322, 2433, 18, 25622, 7898, 5069, 2024, 2905, 1930, 1920, 20275, 15465, 3327, 3]}, "items": [{"id": "p_381", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_382", "content": "phosphorylcreatine [SEP] d previously, and in this study the adenylate energy charge and phosphorylcreatine mole fraction were determined in the adriamycin-treated cells. ", "tokenized_content": [2, 12556, 18662, 13905, 3, 46, 3024, 16, 1930, 1922, 2052, 2161, 1920, 23052, 3844, 7051, 1930, 12556, 18662, 13905, 22372, 3906, 1985, 3180, 1922, 1920, 25622, 7898, 17, 2868, 2094, 3]}, "items": [{"id": "p_382", "content": "Phosphocreatine [SEP] An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders ", "score": 1, "type": null, "tokenized_content": [2, 8078, 18662, 13905, 3, 1925, 5355, 7311, 2435, 4994, 1922, 7345, 3760, 1927, 14976, 18, 2176, 2258, 2252, 15149, 1922, 1920, 2311, 1927, 4435, 4414, 3]}]}
{"query": {"id": "q_383", "content": "phophorylcreatine [SEP] nergy charge was found to be significantly decreased, while the phophorylcreatine mole fraction was unchanged. Such disparity suggests an inhibit", "tokenized_content": [2, 20175, 2102, 2247, 8293, 1936, 13905, 3, 4919, 26983, 7051, 1982, 2435, 1942, 1998, 2567, 3261, 16, 2679, 1920, 20175, 2102, 2247, 8293, 1936, 13905, 22372, 3906, 1982, 9913, 18, 3]}, "items": [{"id": "p_383", "content": "Phosphocreatine [SEP] An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders ", "score": 1, "type": null, "tokenized_content": [2, 8078, 18662, 13905, 3, 1925, 5355, 7311, 2435, 4994, 1922, 7345, 3760, 1927, 14976, 18, 2176, 2258, 2252, 15149, 1922, 1920, 2311, 1927, 4435, 4414, 3]}]}
{"query": {"id": "q_384", "content": "creatine [SEP] ly, and in this study the adenylate energy charge and phosphorylcreatine mole fraction were determined in the adriamycin-treated cells. ", "tokenized_content": [2, 17784, 3, 7518, 16, 1930, 1922, 2052, 2161, 1920, 23052, 3844, 7051, 1930, 12556, 18662, 13905, 22372, 3906, 1985, 3180, 1922, 1920, 25622, 7898, 17, 2868, 2094, 18, 3]}, "items": [{"id": "p_384", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_385", "content": "adenosine [SEP] s an inhibition of creatine phosphokinase. The addition of 1 mM adenosine to the myocardial cell cultures markedly increases the ATP conc", "tokenized_content": [2, 10125, 3, 61, 1925, 3523, 1927, 17784, 8078, 25545, 18, 1920, 2459, 1927, 21, 2489, 10125, 1942, 1920, 6497, 2024, 5054, 7686, 4041, 1920, 4498, 2499, 3]}, "items": [{"id": "p_385", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_386", "content": "ATP [SEP] denosine to the myocardial cell cultures markedly increases the ATP concentration through a pathway reportedly leading to a compart", "tokenized_content": [2, 4498, 3, 4533, 7506, 1942, 1920, 6497, 2024, 5054, 7686, 4041, 1920, 4498, 3110, 2596, 43, 3374, 22455, 4523, 1942, 43, 6508, 3]}, "items": [{"id": "p_386", "content": "Adenosine Triphosphate [SEP] An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in meta", "score": 1, "type": null, "tokenized_content": [2, 10125, 17978, 3, 1925, 15643, 5489, 3165, 2559, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 18, 1922, 2459, 1942, 2496, 6608, 5456, 1922, 5880, 3]}]}
{"query": {"id": "q_387", "content": "neurotoxic [SEP] Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin.", "tokenized_content": [2, 20919, 3, 2632, 17, 3100, 3802, 1927, 1920, 3067, 1942, 20919, 2564, 1927, 10666, 18, 3]}, "items": [{"id": "p_387", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_388", "content": "streptomycin [SEP] Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin.", "tokenized_content": [2, 10666, 3, 2632, 17, 3100, 3802, 1927, 1920, 3067, 1942, 20919, 2564, 1927, 10666, 18, 3]}, "items": [{"id": "p_388", "content": "Streptomycin [SEP] An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation proces", "score": 1, "type": null, "tokenized_content": [2, 10666, 3, 1925, 7267, 4152, 2007, 1920, 6072, 4718, 13386, 11555, 22874, 2398, 2870, 1957, 18, 2176, 8016, 2007, 7918, 1920, 6035, 1930, 9971, 9803, 1036, 3]}]}
{"query": {"id": "q_389", "content": "Streptomycin [SEP] Streptomycin sulfate (300 mg/kg s.c.) was injected for various periods into ", "tokenized_content": [2, 10666, 3, 10666, 8767, 12, 5255, 2786, 19, 3621, 61, 18, 45, 18, 13, 1982, 5624, 1958, 3425, 6696, 2460, 3]}, "items": [{"id": "p_389", "content": "Streptomycin [SEP] An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation proces", "score": 1, "type": null, "tokenized_content": [2, 10666, 3, 1925, 7267, 4152, 2007, 1920, 6072, 4718, 13386, 11555, 22874, 2398, 2870, 1957, 18, 2176, 8016, 2007, 7918, 1920, 6035, 1930, 9971, 9803, 1036, 3]}]}
{"query": {"id": "q_390", "content": "Abnormal movements [SEP] d hearing were examined for 6 and up to 17 weeks, respectively. Abnormal movements and deafness occurred only in rats treated during the preweanin", "tokenized_content": [2, 4552, 8264, 3, 46, 8512, 1985, 3572, 1958, 26, 1930, 2353, 1942, 2752, 3625, 16, 2763, 18, 4552, 8264, 1930, 25371, 4807, 2444, 1922, 3615, 2868, 2409, 1920, 2097, 2172, 3]}, "items": [{"id": "p_390", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_391", "content": "deafness [SEP]  for 6 and up to 17 weeks, respectively. Abnormal movements and deafness occurred only in rats treated during the preweaning period; wit", "tokenized_content": [2, 25371, 3, 1958, 26, 1930, 2353, 1942, 2752, 3625, 16, 2763, 18, 4552, 8264, 1930, 25371, 4807, 2444, 1922, 3615, 2868, 2409, 1920, 2097, 2172, 15393, 1029, 3047, 31, 16086, 3]}, "items": [{"id": "p_391", "content": "Deafness [SEP] A general term for the complete loss of the ability to hear from both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25371, 3, 43, 3335, 2576, 1958, 1920, 4080, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_392", "content": "streptomycin [SEP]  respectively, indicating that the cochlea is more sensitive to streptomycin than the site (vestibular or central) responsible for the dyski", "tokenized_content": [2, 10666, 3, 2763, 16, 4168, 1988, 1920, 23310, 1977, 2253, 4532, 1942, 10666, 2254, 1920, 3200, 12, 15752, 2014, 4101, 13, 5061, 1958, 1920, 3890, 7369, 3]}, "items": [{"id": "p_392", "content": "Streptomycin [SEP] An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation proces", "score": 1, "type": null, "tokenized_content": [2, 10666, 3, 1925, 7267, 4152, 2007, 1920, 6072, 4718, 13386, 11555, 22874, 2398, 2870, 1957, 18, 2176, 8016, 2007, 7918, 1920, 6035, 1930, 9971, 9803, 1036, 3]}]}
{"query": {"id": "q_393", "content": "dyskinesias [SEP] mycin than the site (vestibular or central) responsible for the dyskinesias.", "tokenized_content": [2, 3890, 26682, 1036, 3, 5078, 1921, 2254, 1920, 3200, 12, 15752, 2014, 4101, 13, 5061, 1958, 1920, 3890, 26682, 1036, 18, 3]}, "items": [{"id": "p_393", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_394", "content": "glomerulonephritis [SEP] Crescentic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tub", "tokenized_content": [2, 27057, 3, 18401, 3025, 1935, 28724, 27057, 2458, 1956, 13252, 18332, 1921, 3181, 1958, 5352, 3710, 3]}, "items": [{"id": "p_394", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_395", "content": "rifampin [SEP] ntic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis.", "tokenized_content": [2, 18332, 1921, 3, 5891, 1935, 28724, 27057, 2458, 1956, 13252, 18332, 1921, 3181, 1958, 5352, 8449, 18, 3]}, "items": [{"id": "p_395", "content": "Rifampin [SEP] A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity ag", "score": 1, "type": null, "tokenized_content": [2, 18332, 1921, 3, 43, 8762, 18801, 4905, 4116, 2002, 7267, 4152, 2037, 22874, 16241, 1033, 18, 2176, 2258, 43, 4949, 13021, 5648, 16, 2710, 2455, 2260, 3]}]}
{"query": {"id": "q_396", "content": "pulmonary tuberculosis [SEP] rulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis.", "tokenized_content": [2, 5352, 8449, 3, 7212, 6012, 2912, 2102, 16900, 2458, 1956, 13252, 18332, 1921, 3181, 1958, 5352, 8449, 18, 3]}, "items": [{"id": "p_396", "content": "Tuberculosis, Pulmonary [SEP] MYCOBACTERIUM infections of the lung.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8449, 16, 5352, 3, 16389, 5024, 1927, 1920, 3614, 18, 3]}]}
{"query": {"id": "q_397", "content": "glomerulonephritis [SEP]  reveals an unusual finding of rapidly proliferative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiabl", "tokenized_content": [2, 27057, 3, 9179, 1925, 12236, 2849, 1927, 6221, 9842, 18401, 3025, 1935, 27057, 1922, 43, 2774, 2868, 1956, 18332, 1921, 2746, 2430, 2239, 2303, 2473, 14461, 1024, 3]}, "items": [{"id": "p_397", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_398", "content": "rifampin [SEP] erative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiable causes for developing this diseas", "tokenized_content": [2, 18332, 1921, 3, 14821, 2185, 18401, 3025, 1935, 27057, 1922, 43, 2774, 2868, 1956, 18332, 1921, 2746, 2430, 2239, 2303, 19486, 5092, 1958, 5130, 2052, 2445, 1934, 3]}, "items": [{"id": "p_398", "content": "Rifampin [SEP] A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity ag", "score": 1, "type": null, "tokenized_content": [2, 18332, 1921, 3, 43, 8762, 18801, 4905, 4116, 2002, 7267, 4152, 2037, 22874, 16241, 1033, 18, 2176, 2258, 43, 4949, 13021, 5648, 16, 2710, 2455, 2260, 3]}]}
{"query": {"id": "q_399", "content": "isoniazid [SEP] ease. This patient underwent a 10-month regimen of rifampin and isoniazid for pulmonary tuberculosis and was discovered to have developed", "tokenized_content": [2, 28383, 3, 13832, 18, 2052, 2774, 5468, 43, 2119, 17, 2935, 8607, 1927, 18332, 1921, 1930, 28383, 1958, 5352, 8449, 1930, 1982, 8117, 1942, 2162, 3530, 3]}, "items": [{"id": "p_399", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_400", "content": "pulmonary tuberculosis [SEP] ient underwent a 10-month regimen of rifampin and isoniazid for pulmonary tuberculosis and was discovered to have developed signs of severe renal fail", "tokenized_content": [2, 5352, 8449, 3, 10116, 4905, 5468, 43, 2119, 17, 2935, 8607, 1927, 18332, 1921, 1930, 28383, 1958, 5352, 8449, 1930, 1982, 8117, 1942, 2162, 3530, 6879, 1927, 4010, 4604, 3627, 3]}, "items": [{"id": "p_400", "content": "Tuberculosis, Pulmonary [SEP] MYCOBACTERIUM infections of the lung.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8449, 16, 5352, 3, 16389, 5024, 1927, 1920, 3614, 18, 3]}]}
{"query": {"id": "q_401", "content": "renal failure [SEP] berculosis and was discovered to have developed signs of severe renal failure five weeks after completion of therapy. Renal biopsy revealed s", "tokenized_content": [2, 4604, 4574, 3, 8310, 18021, 6012, 8362, 1930, 1982, 8117, 1942, 2162, 3530, 6879, 1927, 4010, 4604, 4574, 3628, 3625, 2256, 9297, 1927, 3181, 18, 4604, 6831, 3404, 61, 3]}, "items": [{"id": "p_401", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_402", "content": "puromycin aminonucleoside [SEP] Time course of lipid peroxidation in puromycin aminonucleoside-induced nephropathy.", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 2367, 4914, 1927, 4486, 14214, 1922, 19750, 3835, 1022, 2626, 8028, 17, 2719, 15582, 18, 3]}, "items": [{"id": "p_402", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_403", "content": "nephropathy [SEP] urse of lipid peroxidation in puromycin aminonucleoside-induced nephropathy.", "tokenized_content": [2, 15582, 3, 29321, 1021, 1927, 4486, 14214, 1922, 19750, 3835, 1022, 2626, 8028, 17, 2719, 15582, 18, 3]}, "items": [{"id": "p_403", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_404", "content": "oxygen [SEP] Reactive oxygen species have been implicated in the pathogenesis of acute purom", "tokenized_content": [2, 4612, 3, 6079, 4612, 3038, 2162, 2252, 6835, 1922, 1920, 6559, 1927, 3939, 2992, 1947, 3]}, "items": [{"id": "p_404", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_405", "content": "puromycin aminonucleoside [SEP] xygen species have been implicated in the pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly redu", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 20593, 2432, 3038, 2162, 2252, 6835, 1922, 1920, 6559, 1927, 3939, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 17, 2719, 15582, 16, 1956, 3]}, "items": [{"id": "p_405", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_406", "content": "PAN [SEP] licated in the pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly reducing ", "tokenized_content": [2, 3797, 3, 10247, 1981, 1922, 1920, 6559, 1927, 3939, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 17, 2719, 15582, 16, 1956, 14651, 2567, 5526, 3]}, "items": [{"id": "p_406", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_407", "content": "nephropathy [SEP] e pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly reducing the proteinuria. The ", "tokenized_content": [2, 15582, 3, 47, 6559, 1927, 3939, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 17, 2719, 15582, 16, 1956, 14651, 2567, 5526, 1920, 15831, 18, 1920, 3]}, "items": [{"id": "p_407", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_408", "content": "proteinuria [SEP] duced nephropathy, with antioxidants significantly reducing the proteinuria. The temporal relationship between lipid peroxidation in the ki", "tokenized_content": [2, 15831, 3, 10677, 1919, 15582, 16, 1956, 14651, 2567, 5526, 1920, 15831, 18, 1920, 5338, 3303, 2192, 4486, 14214, 1922, 1920, 8191, 3]}, "items": [{"id": "p_408", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_409", "content": "thiobarbituric acid [SEP] le homogenates as well as in lipid extracts from homogenates as thiobarbituric acid reactive substances. Proteinuria was evident at day 5, peaked a", "tokenized_content": [2, 15331, 8751, 5443, 15861, 2687, 3, 2071, 16773, 1966, 2486, 1966, 1922, 4486, 6391, 2037, 16773, 1966, 15331, 8751, 5443, 15861, 2687, 6079, 10054, 18, 15831, 1982, 7501, 2019, 3007, 3]}, "items": [{"id": "p_409", "content": "thiobarbituric acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15331, 8751, 5443, 15861, 2687, 3, 3]}]}
{"query": {"id": "q_410", "content": "Proteinuria [SEP] ts from homogenates as thiobarbituric acid reactive substances. Proteinuria was evident at day 5, peaked at day 7 and persisted to day 27. ", "tokenized_content": [2, 15831, 3, 4894, 2037, 16773, 1966, 15331, 8751, 5443, 15861, 2687, 6079, 10054, 18, 15831, 1982, 7501, 2019, 3007, 25, 16, 18221, 2019, 3007, 27, 1930, 14583, 1942, 3007, 3225, 3]}, "items": [{"id": "p_410", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_411", "content": "proteinuric injury [SEP]  study supports the role of lipid peroxidation in mediating the proteinuric injury in PAN nephropathy.", "tokenized_content": [2, 2213, 15861, 4047, 3, 2161, 7825, 1920, 2770, 1927, 4486, 14214, 1922, 10239, 1920, 2213, 15861, 4047, 1922, 3797, 15582, 18, 3]}, "items": [{"id": "p_411", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_412", "content": "Clomipramine [SEP] Clomipramine-induced sleep disturbance does not impair its prolactin-releasi", "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 12596, 7395, 13399, 25157, 17, 2719, 5006, 12732, 3731, 2084, 3960, 2496, 18386, 17, 2956, 13130, 3]}, "items": [{"id": "p_412", "content": "Clomipramine [SEP] A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily a", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 43, 12258, 13153, 14183, 2551, 1942, 2042, 27085, 1988, 9331, 7042, 1920, 5047, 1927, 11153, 1922, 1920, 3068, 18, 2176, 1977, 8745, 43, 3]}]}
{"query": {"id": "q_413", "content": "sleep disturbance [SEP] Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action.", "tokenized_content": [2, 5006, 12732, 3, 12596, 7395, 13399, 25157, 17, 2719, 5006, 12732, 3731, 2084, 3960, 2496, 18386, 17, 13182, 4615, 18, 3]}, "items": [{"id": "p_413", "content": "Sleep Disorders [SEP] Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major c", "score": 1, "type": null, "tokenized_content": [2, 5006, 4414, 3, 2961, 4378, 2007, 12654, 1927, 10616, 5006, 4147, 2014, 5888, 18, 5006, 4414, 2278, 1998, 5831, 2460, 2559, 3044, 45, 3]}]}
{"query": {"id": "q_414", "content": "sleep disturbance [SEP] The present study was undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate ", "tokenized_content": [2, 5006, 12732, 3, 1920, 2481, 2161, 1982, 10466, 1942, 5020, 1920, 2770, 1927, 5006, 12732, 16, 2719, 2007, 12596, 7395, 13399, 25157, 4183, 16, 1990, 1920, 11518, 2769, 3]}, "items": [{"id": "p_414", "content": "Sleep Disorders [SEP] Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major c", "score": 1, "type": null, "tokenized_content": [2, 5006, 4414, 3, 2961, 4378, 2007, 12654, 1927, 10616, 5006, 4147, 2014, 5888, 18, 5006, 4414, 2278, 1998, 5831, 2460, 2559, 3044, 45, 3]}]}
{"query": {"id": "q_415", "content": "clomipramine [SEP] undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate of prolactin (PRL) in add", "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 10466, 1942, 5020, 1920, 2770, 1927, 5006, 12732, 16, 2719, 2007, 12596, 7395, 13399, 25157, 4183, 16, 1990, 1920, 11518, 2769, 1927, 18386, 12, 15593, 3]}, "items": [{"id": "p_415", "content": "Clomipramine [SEP] A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily a", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 43, 12258, 13153, 14183, 2551, 1942, 2042, 27085, 1988, 9331, 7042, 1920, 5047, 1927, 11153, 1922, 1920, 3068, 18, 2176, 1977, 8745, 43, 3]}]}
{"query": {"id": "q_416", "content": "Angioedema [SEP] Angioedema following the intravenous administration of metoprolol.", "tokenized_content": [2, 29220, 16670, 3, 29220, 16670, 2894, 1920, 7307, 4183, 1927, 2130, 17712, 1945, 18, 3]}, "items": [{"id": "p_416", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_417", "content": "metoprolol [SEP] Angioedema following the intravenous administration of metoprolol.", "tokenized_content": [2, 2130, 17712, 1945, 3, 29220, 16670, 2894, 1920, 7307, 4183, 1927, 2130, 17712, 1945, 18, 3]}, "items": [{"id": "p_417", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_418", "content": "pulmonary edema [SEP] A 72-year-old woman was admitted to the hospital with \"flash\" pulmonary edema, preceded by chest pain, requiring intubation. Her medical hist", "tokenized_content": [2, 5352, 10144, 3, 43, 4395, 17, 2476, 17, 4156, 10440, 1982, 9723, 1942, 1920, 3461, 1956, 6, 13207, 6, 5352, 10144, 16, 16757, 2007, 8475, 3594, 16, 8887, 15686, 18, 3]}, "items": [{"id": "p_418", "content": "Pulmonary Edema [SEP] Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary ", "score": 1, "type": null, "tokenized_content": [2, 5352, 10144, 3, 9122, 4858, 1927, 21263, 18021, 5148, 1005, 5466, 1922, 1920, 3614, 16, 1925, 10331, 1927, 43, 7433, 5030, 2573, 2014, 4770, 18, 5352, 3]}]}
{"query": {"id": "q_419", "content": "chest pain [SEP] itted to the hospital with \"flash\" pulmonary edema, preceded by chest pain, requiring intubation. Her medical history included coronary ar", "tokenized_content": [2, 8475, 3594, 3, 24930, 1919, 1942, 1920, 3461, 1956, 6, 13207, 6, 5352, 10144, 16, 16757, 2007, 8475, 3594, 16, 8887, 15686, 18, 3656, 3423, 4403, 3063, 5846, 2245, 3]}, "items": [{"id": "p_419", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_420", "content": "coronary artery disease [SEP]  chest pain, requiring intubation. Her medical history included coronary artery disease with previous myocardial infarctions, hypertension, and diabete", "tokenized_content": [2, 5846, 5511, 2573, 3, 8475, 3594, 16, 8887, 15686, 18, 3656, 3423, 4403, 3063, 5846, 5511, 2573, 1956, 2555, 6497, 8358, 1036, 16, 5579, 16, 1930, 3517, 11555, 3]}, "items": [{"id": "p_420", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_421", "content": "myocardial infarctions [SEP]  medical history included coronary artery disease with previous myocardial infarctions, hypertension, and diabetes mellitus. A history of angioedema s", "tokenized_content": [2, 6497, 8358, 1036, 3, 3423, 4403, 3063, 5846, 5511, 2573, 1956, 2555, 6497, 8358, 1036, 16, 5579, 16, 1930, 4032, 9695, 18, 43, 4403, 1927, 29220, 16670, 61, 3]}, "items": [{"id": "p_421", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_422", "content": "hypertension [SEP] d coronary artery disease with previous myocardial infarctions, hypertension, and diabetes mellitus. A history of angioedema secondary to li", "tokenized_content": [2, 5579, 3, 46, 5846, 5511, 2573, 1956, 2555, 6497, 8358, 1036, 16, 5579, 16, 1930, 4032, 9695, 18, 43, 4403, 1927, 29220, 16670, 4067, 1942, 2336, 3]}, "items": [{"id": "p_422", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_423", "content": "diabetes mellitus [SEP] disease with previous myocardial infarctions, hypertension, and diabetes mellitus. A history of angioedema secondary to lisinopril therapy was el", "tokenized_content": [2, 4032, 9695, 3, 2573, 1956, 2555, 6497, 8358, 1036, 16, 5579, 16, 1930, 4032, 9695, 18, 43, 4403, 1927, 29220, 16670, 4067, 1942, 19620, 3522, 2047, 1970, 3181, 1982, 2349, 3]}, "items": [{"id": "p_423", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_424", "content": "angioedema [SEP]  infarctions, hypertension, and diabetes mellitus. A history of angioedema secondary to lisinopril therapy was elicited. Current medicatio", "tokenized_content": [2, 29220, 16670, 3, 8358, 1036, 16, 5579, 16, 1930, 4032, 9695, 18, 43, 4403, 1927, 29220, 16670, 4067, 1942, 19620, 3522, 2047, 1970, 3181, 1982, 9856, 18, 3214, 3935, 1968, 3]}, "items": [{"id": "p_424", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_425", "content": "lisinopril [SEP] on, and diabetes mellitus. A history of angioedema secondary to lisinopril therapy was elicited. Current medications did not include angio", "tokenized_content": [2, 19620, 3522, 2047, 1970, 3, 1990, 16, 1930, 4032, 9695, 18, 43, 4403, 1927, 29220, 16670, 4067, 1942, 19620, 3522, 2047, 1970, 3181, 1982, 9856, 18, 3214, 7719, 2811, 2084, 3]}, "items": [{"id": "p_425", "content": "Lisinopril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hype", "score": 1, "type": null, "tokenized_content": [2, 19620, 3522, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 12, 8298, 4472, 13, 16, 12950, 3500, 16, 1988, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 2483, 1021, 3]}]}
{"query": {"id": "q_426", "content": "angiotensin [SEP] opril therapy was elicited. Current medications did not include angiotensin-converting enzyme inhibitors or beta-blockers. She had no previ", "tokenized_content": [2, 10814, 3, 27421, 1970, 3181, 1982, 9856, 18, 3214, 7719, 2811, 2084, 3951, 10814, 17, 15025, 4113, 4472, 2014, 4666, 17, 13628, 18, 4693, 2430, 2239, 2817, 1033, 3]}, "items": [{"id": "p_426", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_427", "content": "metoprolol [SEP] the first day of hospitalization (while intubated), intravenous metoprolol was given, resulting in severe angioedema. The angioedema resol", "tokenized_content": [2, 2130, 17712, 1945, 3, 1920, 2561, 3007, 1927, 9679, 12, 2679, 16079, 7972, 2013, 13, 16, 7307, 2130, 17712, 1945, 1982, 3258, 16, 3864, 1922, 4010, 29220, 16670, 18, 1920, 3]}, "items": [{"id": "p_427", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_428", "content": "steroids [SEP] ioedema. The angioedema resolved after therapy with intravenous steroids and diphenhydramine hydrochloride.", "tokenized_content": [2, 13039, 3, 21509, 16670, 18, 1920, 29220, 16670, 8397, 2256, 3181, 1956, 7307, 13039, 1930, 11791, 18107, 2584, 29085, 2053, 16675, 18, 3]}, "items": [{"id": "p_428", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_429", "content": "diphenhydramine [SEP] angioedema resolved after therapy with intravenous steroids and diphenhydramine hydrochloride.", "tokenized_content": [2, 11791, 18107, 2584, 29085, 2053, 3, 29220, 16670, 8397, 2256, 3181, 1956, 7307, 13039, 1930, 11791, 18107, 2584, 29085, 2053, 16675, 18, 3]}, "items": [{"id": "p_429", "content": "Diphenhydramine [SEP] A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a ", "score": 1, "type": null, "tokenized_content": [2, 11791, 18107, 2584, 29085, 2053, 3, 43, 14622, 9169, 8151, 2251, 1966, 1925, 2246, 17800, 2002, 16, 10310, 3468, 2320, 16, 1958, 13467, 12278, 1930, 27496, 16, 1958, 14625, 5298, 16, 1966, 43, 3]}]}
{"query": {"id": "q_430", "content": "coniine [SEP] Effect of coniine on the developing chick embryo.", "tokenized_content": [2, 1962, 3907, 2912, 3, 2495, 1927, 1962, 3907, 2912, 1990, 1920, 5130, 8006, 9222, 18, 3]}, "items": [{"id": "p_430", "content": "coniine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1962, 3907, 2912, 3, 3]}]}
{"query": {"id": "q_431", "content": "Coniine [SEP] Coniine, an alkaloid from Conium maculatum (poison hemlock), has been s", "tokenized_content": [2, 1962, 3907, 2912, 3, 1962, 3907, 2912, 16, 1925, 29951, 2037, 1962, 2457, 30265, 1031, 1989, 12, 15501, 3243, 26030, 13, 16, 2258, 2252, 61, 3]}, "items": [{"id": "p_431", "content": "coniine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1962, 3907, 2912, 3, 3]}]}
{"query": {"id": "q_432", "content": "arthrogryposis [SEP] o be teratogenic in livestock. The major teratogenic outcome is arthrogryposis, presumably due to nicotinic receptor blockade. However, coniin", "tokenized_content": [2, 9273, 6405, 6907, 2420, 1937, 3, 57, 1998, 18909, 3880, 1922, 17815, 18, 1920, 3044, 18909, 3880, 3924, 1977, 9273, 6405, 6907, 2420, 1937, 16, 9968, 2810, 1942, 20239, 3148, 3]}, "items": [{"id": "p_432", "content": "Arthrogryposis [SEP] Persistent flexure or contracture of a joint. \n    ", "score": 1, "type": null, "tokenized_content": [2, 9273, 6405, 6907, 2420, 1937, 3, 7733, 5795, 2027, 2014, 14456, 2027, 1927, 43, 6047, 18, 3]}]}
{"query": {"id": "q_433", "content": "coniine [SEP] yposis, presumably due to nicotinic receptor blockade. However, coniine has failed to produce arthrogryposis in rats or mice and is onl", "tokenized_content": [2, 1962, 3907, 2912, 3, 21995, 2475, 16, 9968, 2810, 1942, 20239, 3148, 9847, 18, 2406, 16, 1962, 3907, 2912, 2258, 6617, 1942, 5074, 9273, 6405, 6907, 2420, 1937, 1922, 3615, 3]}, "items": [{"id": "p_433", "content": "coniine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1962, 3907, 2912, 3, 3]}]}
{"query": {"id": "q_434", "content": "nicotine [SEP] is study was to evaluate and compare the effects of coniine and nicotine in the developing chick. Concentrations of coniine and nicotine", "tokenized_content": [2, 9303, 3, 1977, 2161, 1982, 1942, 4323, 1930, 5175, 1920, 2564, 1927, 1962, 3907, 2912, 1930, 9303, 1922, 1920, 5130, 8006, 18, 3295, 1927, 1962, 3907, 2912, 1930, 9303, 3]}, "items": [{"id": "p_434", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_435", "content": "deformations [SEP] and 6% and 1%, 5%, and 10%, respectively. Both compounds caused deformations and lethality in a dose-dependent manner. All concentrations of", "tokenized_content": [2, 28900, 3, 1930, 26, 9, 1930, 21, 9, 16, 25, 9, 16, 1930, 2119, 9, 16, 2763, 18, 2321, 4300, 4189, 28900, 1930, 15400, 1922, 43, 3253, 17, 3100, 5222, 3]}, "items": [{"id": "p_435", "content": "Musculoskeletal Diseases [SEP] Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collect", "score": 1, "type": null, "tokenized_content": [2, 15322, 3902, 3, 3902, 1927, 1920, 7848, 1930, 2310, 2458, 27831, 1930, 2303, 14948, 2960, 1930, 1927, 1920, 14153, 1930, 8642, 11103, 11946, 3]}]}
{"query": {"id": "q_436", "content": "excessive flexion or extension of one or more toes [SEP] e deformations caused by both coniine and nicotine sulfate were excessive flexion or extension of one or more toes. No histopathological alterations or differences in bone format", "tokenized_content": [2, 9122, 13326, 2014, 7140, 1927, 2340, 2014, 2253, 22820, 1036, 3, 47, 28900, 4189, 2007, 2321, 1962, 3907, 2912, 1930, 9303, 8767, 1985, 9122, 13326, 2014, 7140, 1927, 2340, 2014, 3]}, "items": [{"id": "p_436", "content": "Musculoskeletal Diseases [SEP] Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collect", "score": 1, "type": null, "tokenized_content": [2, 15322, 3902, 3, 3902, 1927, 1920, 7848, 1930, 2310, 2458, 27831, 1930, 2303, 14948, 2960, 1930, 1927, 1920, 14153, 1930, 8642, 11103, 11946, 3]}]}
{"query": {"id": "q_437", "content": "cranial hemorrhage [SEP]  limbs or toes of any chicks from any group; however, extensive cranial hemorrhage occurred in all nicotine sulfate-treated chicks. There was a st", "tokenized_content": [2, 13598, 10489, 3, 14054, 2014, 22820, 1036, 1927, 2967, 24756, 2037, 2967, 2210, 31, 2406, 16, 6475, 13598, 10489, 4807, 1922, 2136, 9303, 8767, 17, 2868, 24756, 18, 2276, 1982, 3]}, "items": [{"id": "p_437", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_438", "content": "prostaglandin E1 [SEP] Epidural blood flow during prostaglandin E1 or trimethaphan induced hypotension.", "tokenized_content": [2, 15900, 11123, 3, 17282, 2877, 3426, 2409, 15900, 11123, 2014, 23945, 2575, 1928, 2719, 16453, 18, 3]}, "items": [{"id": "p_438", "content": "Alprostadil [SEP] A potent vasodilator agent that increases peripheral blood flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14089, 16289, 2713, 1024, 3, 43, 6828, 28194, 5899, 1988, 4041, 5009, 2877, 3426, 18, 3]}]}
{"query": {"id": "q_439", "content": "trimethaphan [SEP] Epidural blood flow during prostaglandin E1 or trimethaphan induced hypotension.", "tokenized_content": [2, 23945, 2575, 1928, 3, 17282, 2877, 3426, 2409, 15900, 11123, 2014, 23945, 2575, 1928, 2719, 16453, 18, 3]}, "items": [{"id": "p_439", "content": "Trimethaphan [SEP] A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hy", "score": 1, "type": null, "tokenized_content": [2, 23945, 2575, 1928, 3, 43, 20239, 8151, 1988, 2258, 2252, 2251, 1966, 43, 12516, 1935, 14580, 1922, 5579, 16, 1966, 1925, 22481, 1942, 8871, 16, 1930, 1942, 4769, 4527, 3]}]}
{"query": {"id": "q_440", "content": "hypotension [SEP] ural blood flow during prostaglandin E1 or trimethaphan induced hypotension.", "tokenized_content": [2, 16453, 3, 3674, 1923, 2877, 3426, 2409, 15900, 11123, 2014, 23945, 2575, 1928, 2719, 16453, 18, 3]}, "items": [{"id": "p_440", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_441", "content": "prostaglandin E1 [SEP] To evaluate the effect of prostaglandin E1 (PGE1) or trimethaphan (TMP) induced hypotension on epidural bl", "tokenized_content": [2, 15900, 11123, 3, 1942, 4323, 1920, 2495, 1927, 15900, 11123, 12, 11435, 1009, 13, 2014, 23945, 2575, 1928, 12, 23992, 13, 2719, 16453, 1990, 17282, 2266, 3]}, "items": [{"id": "p_441", "content": "Alprostadil [SEP] A potent vasodilator agent that increases peripheral blood flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14089, 16289, 2713, 1024, 3, 43, 6828, 28194, 5899, 1988, 4041, 5009, 2877, 3426, 18, 3]}]}
{"query": {"id": "q_442", "content": "PGE1 [SEP] To evaluate the effect of prostaglandin E1 (PGE1) or trimethaphan (TMP) induced hypotension on epidural blood fl", "tokenized_content": [2, 11435, 1009, 3, 1942, 4323, 1920, 2495, 1927, 15900, 11123, 12, 11435, 1009, 13, 2014, 23945, 2575, 1928, 12, 23992, 13, 2719, 16453, 1990, 17282, 2877, 2300, 3]}, "items": [{"id": "p_442", "content": "Alprostadil [SEP] A potent vasodilator agent that increases peripheral blood flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14089, 16289, 2713, 1024, 3, 43, 6828, 28194, 5899, 1988, 4041, 5009, 2877, 3426, 18, 3]}]}
{"query": {"id": "q_443", "content": "trimethaphan [SEP] To evaluate the effect of prostaglandin E1 (PGE1) or trimethaphan (TMP) induced hypotension on epidural blood flow (EBF) during s", "tokenized_content": [2, 23945, 2575, 1928, 3, 1942, 4323, 1920, 2495, 1927, 15900, 11123, 12, 11435, 1009, 13, 2014, 23945, 2575, 1928, 12, 23992, 13, 2719, 16453, 1990, 17282, 2877, 3426, 12, 6560, 3]}, "items": [{"id": "p_443", "content": "Trimethaphan [SEP] A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hy", "score": 1, "type": null, "tokenized_content": [2, 23945, 2575, 1928, 3, 43, 20239, 8151, 1988, 2258, 2252, 2251, 1966, 43, 12516, 1935, 14580, 1922, 5579, 16, 1966, 1925, 22481, 1942, 8871, 16, 1930, 1942, 4769, 4527, 3]}]}
{"query": {"id": "q_444", "content": "TMP [SEP] evaluate the effect of prostaglandin E1 (PGE1) or trimethaphan (TMP) induced hypotension on epidural blood flow (EBF) during spinal", "tokenized_content": [2, 23992, 3, 4323, 1920, 2495, 1927, 15900, 11123, 12, 11435, 1009, 13, 2014, 23945, 2575, 1928, 12, 23992, 13, 2719, 16453, 1990, 17282, 2877, 3426, 12, 6560, 1038, 13, 2409, 3]}, "items": [{"id": "p_444", "content": "Trimethaphan [SEP] A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hy", "score": 1, "type": null, "tokenized_content": [2, 23945, 2575, 1928, 3, 43, 20239, 8151, 1988, 2258, 2252, 2251, 1966, 43, 12516, 1935, 14580, 1922, 5579, 16, 1966, 1925, 22481, 1942, 8871, 16, 1930, 1942, 4769, 4527, 3]}]}
{"query": {"id": "q_445", "content": "hypotension [SEP] effect of prostaglandin E1 (PGE1) or trimethaphan (TMP) induced hypotension on epidural blood flow (EBF) during spinal surgery, EBF was mea", "tokenized_content": [2, 16453, 3, 2495, 1927, 15900, 11123, 12, 11435, 1009, 13, 2014, 23945, 2575, 1928, 12, 23992, 13, 2719, 16453, 1990, 17282, 2877, 3426, 12, 6560, 1038, 13, 2409, 6071, 3782, 3]}, "items": [{"id": "p_445", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_446", "content": "isoflurane [SEP] 0 patients who underwent postero-lateral interbody fusion under isoflurane anaesthesia. An initial dose of 0.1 microgram.kg-1.min-1 of PGE", "tokenized_content": [2, 15362, 3, 20, 2132, 2746, 5468, 21270, 1037, 17, 5347, 2107, 19665, 5289, 2441, 15362, 17107, 18, 1925, 3754, 3253, 1927, 20, 18, 21, 23460, 18, 3621, 17, 21, 18, 3]}, "items": [{"id": "p_446", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_447", "content": "hypotensive [SEP] in the mean arterial blood pressure (MAP) at about 60 mmHg. The hypotensive drug was discontinued at the completion of the operative proced", "tokenized_content": [2, 12201, 3766, 3, 1922, 1920, 2667, 6624, 2877, 3772, 12, 4446, 13, 2019, 3001, 3276, 9348, 18, 1920, 12201, 3766, 2838, 1982, 16087, 2019, 1920, 9297, 1927, 1920, 8116, 3420, 3]}, "items": [{"id": "p_447", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_448", "content": "axonal damage [SEP] tochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat.", "tokenized_content": [2, 10623, 4293, 3, 21682, 20730, 2046, 2351, 1956, 3788, 1942, 19200, 19167, 2017, 2697, 1990, 10623, 4293, 1922, 3599, 8083, 4518, 1922, 3067, 18, 3]}, "items": [{"id": "p_448", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_449", "content": "axonal injury [SEP] d high molecular weight class, NF-M and NF-H, was used to study axonal injury in the borderzone of focal lesions in rats. Focal injury in the", "tokenized_content": [2, 10623, 4047, 3, 46, 2149, 3272, 3388, 2921, 16, 4651, 17, 55, 1930, 4651, 17, 50, 16, 1982, 2251, 1942, 2161, 10623, 4047, 1922, 1920, 9380, 13642, 2912, 1927, 8083, 3]}, "items": [{"id": "p_449", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_450", "content": "injury in the cortex [SEP] axonal injury in the borderzone of focal lesions in rats. Focal injury in the cortex was produced by infusion of lactate at acid pH or by stab cause", "tokenized_content": [2, 4047, 1922, 1920, 4997, 3, 10623, 4047, 1922, 1920, 9380, 13642, 2912, 1927, 8083, 4518, 1922, 3615, 18, 8083, 4047, 1922, 1920, 4997, 1982, 4152, 2007, 7386, 1927, 9456, 2019, 3]}, "items": [{"id": "p_450", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_451", "content": "lactate [SEP] in rats. Focal injury in the cortex was produced by infusion of lactate at acid pH or by stab caused by needle insertion. Infarcts in s", "tokenized_content": [2, 9456, 3, 1922, 3615, 18, 8083, 4047, 1922, 1920, 4997, 1982, 4152, 2007, 7386, 1927, 9456, 2019, 2687, 2087, 2014, 2007, 23891, 1014, 4189, 2007, 9351, 7413, 18, 28701, 1922, 3]}, "items": [{"id": "p_451", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_452", "content": "Infarcts in substantia nigra pars reticulata [SEP] on of lactate at acid pH or by stab caused by needle insertion. Infarcts in substantia nigra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus", "tokenized_content": [2, 28701, 1922, 21229, 20102, 12505, 18905, 5499, 3, 1990, 1927, 9456, 2019, 2687, 2087, 2014, 2007, 23891, 1014, 4189, 2007, 9351, 7413, 18, 28701, 1922, 21229, 20102, 12505, 18905, 5499, 3]}, "items": [{"id": "p_452", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_453", "content": "pilocarpine [SEP] ts in substantia nigra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus. Immunohistochemical staining for NF", "tokenized_content": [2, 7547, 7095, 12184, 3, 4894, 1922, 21229, 20102, 12505, 18905, 5499, 1985, 8782, 2007, 7171, 7547, 7095, 12184, 17, 2719, 3642, 16304, 1957, 18, 9885, 4166, 1958, 4651, 3]}, "items": [{"id": "p_453", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_454", "content": "status epilepticus [SEP] ra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus. Immunohistochemical staining for NFs showed characteristic ter", "tokenized_content": [2, 3642, 16304, 1957, 3, 4313, 12505, 18905, 5499, 1985, 8782, 2007, 7171, 7547, 7095, 12184, 17, 2719, 3642, 16304, 1957, 18, 9885, 4166, 1958, 4651, 1036, 2594, 6293, 6005, 3]}, "items": [{"id": "p_454", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_455", "content": "axonal damage [SEP] se immunohistochemical changes of NFs can serve as a marker for axonal damage in various experimental traumatic or ischemic lesions.", "tokenized_content": [2, 10623, 4293, 3, 2058, 9885, 2840, 1927, 4651, 1036, 2112, 7120, 1966, 43, 4966, 1958, 10623, 4293, 1922, 3425, 3599, 10242, 2014, 7427, 4518, 18, 3]}, "items": [{"id": "p_455", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_456", "content": "traumatic [SEP] can serve as a marker for axonal damage in various experimental traumatic or ischemic lesions.", "tokenized_content": [2, 10242, 3, 2112, 7120, 1966, 43, 4966, 1958, 10623, 4293, 1922, 3425, 3599, 10242, 2014, 7427, 4518, 18, 3]}, "items": [{"id": "p_456", "content": "Wounds and Injuries [SEP] Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural con", "score": 1, "type": null, "tokenized_content": [2, 14107, 1930, 8209, 3, 4293, 2552, 5847, 1919, 1990, 1920, 3362, 1966, 1920, 3083, 2014, 6354, 3211, 1927, 1925, 5771, 5495, 16, 1956, 2014, 2979, 7561, 1927, 4346, 1962, 3]}]}
{"query": {"id": "q_457", "content": "Parkinson disability [SEP] Increase of Parkinson disability after fluoxetine medication.", "tokenized_content": [2, 10124, 8015, 3, 2760, 1927, 10124, 8015, 2256, 22176, 6093, 18, 3]}, "items": [{"id": "p_457", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_458", "content": "fluoxetine [SEP] Increase of Parkinson disability after fluoxetine medication.", "tokenized_content": [2, 22176, 3, 2760, 1927, 10124, 8015, 2256, 22176, 6093, 18, 3]}, "items": [{"id": "p_458", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_459", "content": "Depression [SEP] Depression is a major clinical feature of Parkinson's disease. We report t", "tokenized_content": [2, 4621, 3, 4621, 1977, 43, 3044, 2535, 5961, 1927, 10124, 11, 61, 2573, 18, 2038, 3809, 62, 3]}, "items": [{"id": "p_459", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_460", "content": "Parkinson's disease [SEP] Depression is a major clinical feature of Parkinson's disease. We report the increased amount of motor disability in four pat", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 4621, 1977, 43, 3044, 2535, 5961, 1927, 10124, 11, 61, 2573, 18, 2038, 3809, 1920, 2502, 4351, 1927, 4842, 8015, 1922, 3006, 2917, 3]}, "items": [{"id": "p_460", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_461", "content": "motor disability [SEP] ature of Parkinson's disease. We report the increased amount of motor disability in four patients with idiopathic Parkinson's disease after expo", "tokenized_content": [2, 4842, 8015, 3, 2019, 2027, 1927, 10124, 11, 61, 2573, 18, 2038, 3809, 1920, 2502, 4351, 1927, 4842, 8015, 1922, 3006, 2132, 1956, 13513, 10124, 11, 61, 2573, 2256, 2887, 3]}, "items": [{"id": "p_461", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_462", "content": "idiopathic Parkinson's disease [SEP]  the increased amount of motor disability in four patients with idiopathic Parkinson's disease after exposure to the antidepressant fluoxetine. The possibilit", "tokenized_content": [2, 13513, 10124, 11, 61, 2573, 3, 1920, 2502, 4351, 1927, 4842, 8015, 1922, 3006, 2132, 1956, 13513, 10124, 11, 61, 2573, 2256, 3395, 1942, 1920, 14183, 22176, 18, 1920, 2776, 3]}, "items": [{"id": "p_462", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_463", "content": "antidepressant [SEP] ients with idiopathic Parkinson's disease after exposure to the antidepressant fluoxetine. The possibility of a clinically relevant dopamine-a", "tokenized_content": [2, 14183, 3, 10116, 4905, 1036, 1956, 13513, 10124, 11, 61, 2573, 2256, 3395, 1942, 1920, 14183, 22176, 18, 1920, 5341, 1927, 43, 5908, 4494, 7964, 17, 43, 3]}, "items": [{"id": "p_463", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_464", "content": "fluoxetine [SEP] pathic Parkinson's disease after exposure to the antidepressant fluoxetine. The possibility of a clinically relevant dopamine-antagonistic", "tokenized_content": [2, 22176, 3, 2450, 1935, 10124, 11, 61, 2573, 2256, 3395, 1942, 1920, 14183, 22176, 18, 1920, 5341, 1927, 43, 5908, 4494, 7964, 17, 19052, 3]}, "items": [{"id": "p_464", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_465", "content": "dopamine [SEP] depressant fluoxetine. The possibility of a clinically relevant dopamine-antagonistic capacity of fluoxetine in Parkinson's disease pati", "tokenized_content": [2, 7964, 3, 20852, 2031, 22176, 18, 1920, 5341, 1927, 43, 5908, 4494, 7964, 17, 19052, 4796, 1927, 22176, 1922, 10124, 11, 61, 2573, 2091, 3]}, "items": [{"id": "p_465", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_466", "content": "Acetaminophen [SEP] Acetaminophen-induced hypotension.", "tokenized_content": [2, 23311, 3, 23311, 17, 2719, 16453, 18, 3]}, "items": [{"id": "p_466", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_467", "content": "hypotension [SEP] Acetaminophen-induced hypotension.", "tokenized_content": [2, 16453, 3, 23311, 17, 2719, 16453, 18, 3]}, "items": [{"id": "p_467", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_468", "content": "acetaminophen [SEP] Through 30 years of widespread use, acetaminophen has been shown to be a remarkably safe medication in therapeuti", "tokenized_content": [2, 23311, 3, 2596, 2627, 2739, 1927, 9360, 2485, 16, 23311, 2258, 2252, 2522, 1942, 1998, 43, 10877, 7672, 6093, 1922, 4055, 1914, 3]}, "items": [{"id": "p_468", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_469", "content": "cardiovascular toxicities [SEP] therapeutic dosages. The potential for acetaminophen to produce cardiovascular toxicities is very low. However, acetaminophen has been demonstrated to pr", "tokenized_content": [2, 5321, 15251, 3, 4272, 20549, 18, 1920, 2889, 1958, 23311, 1942, 5074, 5321, 15251, 1977, 3345, 2330, 18, 2406, 16, 23311, 2258, 2252, 3161, 1942, 2033, 3]}, "items": [{"id": "p_469", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_470", "content": "anaphylaxis [SEP] ver, acetaminophen has been demonstrated to produce symptoms of anaphylaxis, including hypotension, in sensitive individuals. This article ", "tokenized_content": [2, 26726, 3, 3566, 16, 23311, 2258, 2252, 3161, 1942, 5074, 3601, 1927, 26726, 16, 2710, 16453, 16, 1922, 4532, 3445, 18, 2052, 5868, 3]}, "items": [{"id": "p_470", "content": "Anaphylaxis [SEP] An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progres", "score": 1, "type": null, "tokenized_content": [2, 26726, 3, 1925, 3939, 14625, 3227, 2810, 1942, 3395, 1942, 43, 3024, 11989, 4730, 18, 1920, 3227, 2278, 3951, 6221, 2745, 1918, 3]}]}
{"query": {"id": "q_471", "content": "hypotension [SEP] been demonstrated to produce symptoms of anaphylaxis, including hypotension, in sensitive individuals. This article describes two criticall", "tokenized_content": [2, 16453, 3, 2252, 3161, 1942, 5074, 3601, 1927, 26726, 16, 2710, 16453, 16, 1922, 4532, 3445, 18, 2052, 5868, 9845, 2288, 4140, 1024, 3]}, "items": [{"id": "p_471", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_472", "content": "critically ill [SEP] potension, in sensitive individuals. This article describes two critically ill patients in whom transient episodes of hypotension reproducibly", "tokenized_content": [2, 9790, 3652, 3, 2543, 3212, 16, 1922, 4532, 3445, 18, 2052, 5868, 9845, 2288, 9790, 3652, 2132, 1922, 8566, 6809, 9232, 1927, 16453, 5131, 5898, 3]}, "items": [{"id": "p_472", "content": "Critical Illness [SEP] A disease or state in which death is possible or imminent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4140, 6455, 3, 43, 2573, 2014, 3360, 1922, 2154, 3539, 1977, 3216, 2014, 4960, 2053, 4905, 18, 3]}]}
{"query": {"id": "q_473", "content": "allergic reactions [SEP] eloped after administration of acetaminophen. Other symptoms of allergic reactions were not clinically detectable. The hypotensive episodes were s", "tokenized_content": [2, 10519, 5298, 3, 2349, 4907, 1007, 2256, 4183, 1927, 23311, 18, 2303, 3601, 1927, 10519, 5298, 1985, 2084, 5908, 7398, 18, 1920, 12201, 3766, 9232, 1985, 61, 3]}, "items": [{"id": "p_473", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_474", "content": "hypotensive [SEP] ptoms of allergic reactions were not clinically detectable. The hypotensive episodes were severe enough to require vasopressor administrati", "tokenized_content": [2, 12201, 3766, 3, 4401, 18995, 1927, 10519, 5298, 1985, 2084, 5908, 7398, 18, 1920, 12201, 3766, 9232, 1985, 4010, 7867, 1942, 4350, 17598, 1924, 10473, 1968, 3]}, "items": [{"id": "p_474", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_475", "content": "hepatitis [SEP] Acute hepatitis, autoimmune hemolytic anemia, and erythroblastocytopenia induce", "tokenized_content": [2, 7977, 3, 3939, 7977, 16, 8904, 21515, 10679, 16, 1930, 25940, 12019, 3107, 12903, 4769, 3]}, "items": [{"id": "p_475", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_476", "content": "autoimmune hemolytic anemia [SEP] Acute hepatitis, autoimmune hemolytic anemia, and erythroblastocytopenia induced by ceftriaxone.", "tokenized_content": [2, 8904, 21515, 10679, 3, 3939, 7977, 16, 8904, 21515, 10679, 16, 1930, 25940, 12019, 3107, 12903, 2719, 2007, 28248, 18, 3]}, "items": [{"id": "p_476", "content": "Anemia, Hemolytic, Autoimmune [SEP] Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.\n   ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 16, 8904, 3, 5815, 21515, 10679, 2810, 1942, 1920, 2990, 1927, 15510, 2154, 20262, 2010, 2014, 3629, 1021, 1920, 2774, 11, 61, 6614, 2312, 2877, 2094, 18, 3]}]}
{"query": {"id": "q_477", "content": "ceftriaxone [SEP] oimmune hemolytic anemia, and erythroblastocytopenia induced by ceftriaxone.", "tokenized_content": [2, 28248, 3, 25166, 7445, 17014, 21515, 10679, 16, 1930, 25940, 12019, 3107, 12903, 2719, 2007, 28248, 18, 3]}, "items": [{"id": "p_477", "content": "Ceftriaxone [SEP] A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.\n  ", "score": 1, "type": null, "tokenized_content": [2, 28248, 3, 43, 4949, 17, 5648, 25091, 1921, 7267, 1956, 43, 3345, 2815, 4768, 17, 3308, 1930, 2149, 8126, 2550, 1942, 10286, 1918, 16, 7127, 1930, 6671, 19332, 18, 3]}]}
{"query": {"id": "q_478", "content": "hepatitis [SEP] An 80-yr-old man developed acute hepatitis shortly after ingesting oral ceftriaxone. Although the transami", "tokenized_content": [2, 7977, 3, 1925, 3729, 17, 13031, 17, 4156, 2323, 3530, 3939, 7977, 17002, 2256, 11378, 2104, 4726, 28248, 18, 2876, 1920, 2127, 14981, 3]}, "items": [{"id": "p_478", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_479", "content": "ceftriaxone [SEP] -old man developed acute hepatitis shortly after ingesting oral ceftriaxone. Although the transaminases gradually returned to baseline afte", "tokenized_content": [2, 28248, 3, 17, 4156, 2323, 3530, 3939, 7977, 17002, 2256, 11378, 2104, 4726, 28248, 18, 2876, 1920, 24376, 1036, 9690, 10418, 1942, 3703, 2221, 2057, 3]}, "items": [{"id": "p_479", "content": "Ceftriaxone [SEP] A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.\n  ", "score": 1, "type": null, "tokenized_content": [2, 28248, 3, 43, 4949, 17, 5648, 25091, 1921, 7267, 1956, 43, 3345, 2815, 4768, 17, 3308, 1930, 2149, 8126, 2550, 1942, 10286, 1918, 16, 7127, 1930, 6671, 19332, 18, 3]}]}
{"query": {"id": "q_480", "content": "beta lactam [SEP] nsaminases gradually returned to baseline after withholding the beta lactam antibiotic, there was a gradual increase in serum bilirubin and", "tokenized_content": [2, 4666, 15294, 3, 4246, 15848, 1036, 9690, 10418, 1942, 3703, 2256, 1956, 3896, 1941, 1920, 4666, 15294, 7267, 16, 2276, 1982, 43, 13802, 2760, 1922, 3256, 15702, 1930, 3]}, "items": [{"id": "p_480", "content": "beta-Lactams [SEP] Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 15294, 1036, 3, 3006, 17, 30261, 9821, 13601, 1036, 16, 4534, 3171, 1958, 1920, 9957, 1036, 2454, 1990, 43, 8876, 3143, 1037, 17, 27225, 11300, 2053, 16, 1966, 2486, 1966, 1920, 25091, 2925, 2454, 3]}]}
{"query": {"id": "q_481", "content": "bilirubin [SEP] e beta lactam antibiotic, there was a gradual increase in serum bilirubin and a decrease in hemoglobin concentration caused by an autoimm", "tokenized_content": [2, 15702, 3, 47, 4666, 15294, 7267, 16, 2276, 1982, 43, 13802, 2760, 1922, 3256, 15702, 1930, 43, 3714, 1922, 9652, 3110, 4189, 2007, 1925, 5728, 1980, 1035, 3]}, "items": [{"id": "p_481", "content": "Bilirubin [SEP] A bile pigment that is a degradation product of HEME.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15702, 3, 43, 9619, 12905, 1988, 1977, 43, 4877, 4863, 1927, 10954, 18, 3]}]}
{"query": {"id": "q_482", "content": "autoimmune hemolytic anemia [SEP] lirubin and a decrease in hemoglobin concentration caused by an autoimmune hemolytic anemia and erythroblastocytopenia. These responded to systemic steroid", "tokenized_content": [2, 8904, 21515, 10679, 3, 24505, 13841, 1930, 43, 3714, 1922, 9652, 3110, 4189, 2007, 1925, 8904, 21515, 10679, 1930, 25940, 12019, 3107, 12903, 18, 2144, 10711, 1942, 5510, 9507, 3]}, "items": [{"id": "p_482", "content": "Anemia, Hemolytic, Autoimmune [SEP] Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.\n   ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 16, 8904, 3, 5815, 21515, 10679, 2810, 1942, 1920, 2990, 1927, 15510, 2154, 20262, 2010, 2014, 3629, 1021, 1920, 2774, 11, 61, 6614, 2312, 2877, 2094, 18, 3]}]}
{"query": {"id": "q_483", "content": "steroids [SEP]  anemia and erythroblastocytopenia. These responded to systemic steroids and immunoglobulins. Despite the widespread use of these agents", "tokenized_content": [2, 13039, 3, 10679, 1930, 25940, 12019, 3107, 12903, 18, 2144, 10711, 1942, 5510, 13039, 1930, 26330, 18, 4281, 1920, 9360, 2485, 1927, 2144, 4820, 3]}, "items": [{"id": "p_483", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_484", "content": "extrapyramidal symptoms [SEP] ociated with unwanted central nervous system effects, including extrapyramidal symptoms (EPS), tardive dyskinesia, sedation, and possible impairment of", "tokenized_content": [2, 21346, 3553, 25238, 1923, 3601, 3, 5084, 23682, 1956, 20140, 4101, 7580, 2433, 2564, 16, 2710, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 16, 14517, 7408, 1961, 3890, 26682, 3]}, "items": [{"id": "p_484", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_485", "content": "EPS [SEP] tral nervous system effects, including extrapyramidal symptoms (EPS), tardive dyskinesia, sedation, and possible impairment of some", "tokenized_content": [2, 9178, 3, 3390, 1024, 7580, 2433, 2564, 16, 2710, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 16, 14517, 7408, 1961, 3890, 26682, 16, 15263, 16, 1930, 3216, 6159, 1927, 3]}, "items": [{"id": "p_485", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_486", "content": "tardive dyskinesia [SEP] ervous system effects, including extrapyramidal symptoms (EPS), tardive dyskinesia, sedation, and possible impairment of some cognitive measures, ", "tokenized_content": [2, 14517, 7408, 1961, 3890, 26682, 3, 2668, 15525, 1957, 2433, 2564, 16, 2710, 21346, 3553, 25238, 1923, 3601, 12, 9178, 13, 16, 14517, 7408, 1961, 3890, 26682, 16, 15263, 16, 3]}, "items": [{"id": "p_486", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_487", "content": "orthostatic hypotension [SEP] airment of some cognitive measures, as well as cardiac effects, orthostatic hypotension, hepatic changes, anticholinergic side effects, sexual dysfunct", "tokenized_content": [2, 24343, 11494, 16453, 3, 4433, 2017, 1927, 2673, 4328, 3975, 16, 1966, 2486, 1966, 4435, 2564, 16, 24343, 11494, 16453, 16, 6095, 2840, 16, 5851, 12074, 12745, 4159, 2564, 16, 3]}, "items": [{"id": "p_487", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_488", "content": "sexual dysfunction [SEP] tic hypotension, hepatic changes, anticholinergic side effects, sexual dysfunction, and weight gain. The newer atypical agents have a lower risk o", "tokenized_content": [2, 5702, 5273, 3, 18298, 16453, 16, 6095, 2840, 16, 5851, 12074, 12745, 4159, 2564, 16, 5702, 5273, 16, 1930, 3388, 5938, 18, 1920, 18012, 10834, 4820, 2162, 43, 2826, 2565, 3]}, "items": [{"id": "p_488", "content": "Sexual Dysfunction, Physiological [SEP] Physiological disturbances in normal sexual performance in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5702, 5273, 16, 5005, 3, 5005, 12654, 1922, 2791, 5702, 3604, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_489", "content": "weight gain [SEP]  changes, anticholinergic side effects, sexual dysfunction, and weight gain. The newer atypical agents have a lower risk of EPS, but are as", "tokenized_content": [2, 3388, 5938, 3, 2840, 16, 5851, 12074, 12745, 4159, 2564, 16, 5702, 5273, 16, 1930, 3388, 5938, 18, 1920, 18012, 10834, 4820, 2162, 43, 2826, 2565, 1927, 9178, 16, 2308, 3]}, "items": [{"id": "p_489", "content": "Weight Gain [SEP] Increase in BODY WEIGHT over existing weight.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3388, 5938, 3, 2760, 1922, 3362, 3388, 2338, 6124, 3388, 18, 3]}]}
{"query": {"id": "q_490", "content": "seizure [SEP] ects, weight gain, sexual dysfunction, hepatic effects, lowered seizure threshold (primarily clozapine), and agranulocytosis (clozapine", "tokenized_content": [2, 11015, 3, 7495, 1036, 16, 3388, 5938, 16, 5702, 5273, 16, 6095, 2564, 16, 13786, 11015, 4683, 12, 5985, 24424, 13, 16, 1930, 23171, 1928, 1944, 7349, 12, 24424, 3]}, "items": [{"id": "p_490", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_491", "content": "clozapine [SEP] function, hepatic effects, lowered seizure threshold (primarily clozapine), and agranulocytosis (clozapine only). Since the incidence and", "tokenized_content": [2, 24424, 3, 2347, 16, 6095, 2564, 16, 13786, 11015, 4683, 12, 5985, 24424, 13, 16, 1930, 23171, 1928, 1944, 7349, 12, 24424, 2444, 13, 18, 3328, 1920, 4332, 1930, 3]}, "items": [{"id": "p_491", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_492", "content": "agranulocytosis [SEP] c effects, lowered seizure threshold (primarily clozapine), and agranulocytosis (clozapine only). Since the incidence and severity of specific ", "tokenized_content": [2, 23171, 1928, 1944, 7349, 3, 45, 2564, 16, 13786, 11015, 4683, 12, 5985, 24424, 13, 16, 1930, 23171, 1928, 1944, 7349, 12, 24424, 2444, 13, 18, 3328, 1920, 4332, 1930, 3]}, "items": [{"id": "p_492", "content": "Agranulocytosis [SEP] A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 23171, 1928, 1944, 7349, 3, 43, 3714, 1922, 1920, 2529, 1927, 22144, 31, 12, 29929, 31, 15854, 31, 1930, 8508, 13, 18, 3]}]}
{"query": {"id": "q_493", "content": "tetrandrine [SEP] Effects of tetrandrine and fangchinoline on experimental thrombosis in mice and human ", "tokenized_content": [2, 12470, 10249, 5773, 3, 2564, 1927, 12470, 10249, 5773, 1930, 19764, 5813, 7969, 11873, 3701, 1990, 3599, 11354, 1922, 2518, 1930, 2616, 3]}, "items": [{"id": "p_493", "content": "tetrandrine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12470, 10249, 5773, 3, 3]}]}
{"query": {"id": "q_494", "content": "fangchinoline [SEP] Effects of tetrandrine and fangchinoline on experimental thrombosis in mice and human platelet aggregati", "tokenized_content": [2, 19764, 5813, 7969, 11873, 3701, 3, 2564, 1927, 12470, 10249, 5773, 1930, 19764, 5813, 7969, 11873, 3701, 1990, 3599, 11354, 1922, 2518, 1930, 2616, 7163, 5206, 1968, 3]}, "items": [{"id": "p_494", "content": "fangchinoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 19764, 5813, 7969, 11873, 3701, 3, 3]}]}
{"query": {"id": "q_495", "content": "thrombosis [SEP] Effects of tetrandrine and fangchinoline on experimental thrombosis in mice and human platelet aggregation.", "tokenized_content": [2, 11354, 3, 2564, 1927, 12470, 10249, 5773, 1930, 19764, 5813, 7969, 11873, 3701, 1990, 3599, 11354, 1922, 2518, 1930, 2616, 7163, 7883, 18, 3]}, "items": [{"id": "p_495", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_496", "content": "platelet aggregation [SEP]  and fangchinoline on experimental thrombosis in mice and human platelet aggregation.", "tokenized_content": [2, 7163, 7883, 3, 1930, 19764, 5813, 7969, 11873, 3701, 1990, 3599, 11354, 1922, 2518, 1930, 2616, 7163, 7883, 18, 3]}, "items": [{"id": "p_496", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_497", "content": "Tetrandrine [SEP] Tetrandrine (TET) and fangchinoline (FAN) are two naturally occurring analo", "tokenized_content": [2, 12470, 10249, 5773, 3, 12470, 10249, 5773, 12, 9717, 13, 1930, 19764, 5813, 7969, 11873, 3701, 12, 19764, 13, 2032, 2288, 10414, 6966, 2151, 1037, 3]}, "items": [{"id": "p_497", "content": "tetrandrine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12470, 10249, 5773, 3, 3]}]}
{"query": {"id": "q_498", "content": "TET [SEP] Tetrandrine (TET) and fangchinoline (FAN) are two naturally occurring analogues ", "tokenized_content": [2, 9717, 3, 12470, 10249, 5773, 12, 9717, 13, 1930, 19764, 5813, 7969, 11873, 3701, 12, 19764, 13, 2032, 2288, 10414, 6966, 13645, 3]}, "items": [{"id": "p_498", "content": "tetrandrine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 12470, 10249, 5773, 3, 3]}]}
{"query": {"id": "q_499", "content": "fangchinoline [SEP] Tetrandrine (TET) and fangchinoline (FAN) are two naturally occurring analogues with a bisbenzyliso", "tokenized_content": [2, 19764, 5813, 7969, 11873, 3701, 3, 12470, 10249, 5773, 12, 9717, 13, 1930, 19764, 5813, 7969, 11873, 3701, 12, 19764, 13, 2032, 2288, 10414, 6966, 13645, 1956, 43, 7266, 13058, 3]}, "items": [{"id": "p_499", "content": "fangchinoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 19764, 5813, 7969, 11873, 3701, 3, 3]}]}
{"query": {"id": "q_500", "content": "FAN [SEP] Tetrandrine (TET) and fangchinoline (FAN) are two naturally occurring analogues with a bisbenzylisoquino", "tokenized_content": [2, 19764, 3, 12470, 10249, 5773, 12, 9717, 13, 1930, 19764, 5813, 7969, 11873, 3701, 12, 19764, 13, 2032, 2288, 10414, 6966, 13645, 1956, 43, 7266, 13058, 2199, 23854, 11072, 1037, 3]}, "items": [{"id": "p_500", "content": "fangchinoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 19764, 5813, 7969, 11873, 3701, 3, 3]}]}
{"query": {"id": "q_501", "content": "bisbenzylisoquinoline [SEP] angchinoline (FAN) are two naturally occurring analogues with a bisbenzylisoquinoline structure. The present study was undertaken to investigate the ", "tokenized_content": [2, 7266, 13058, 2199, 23854, 11072, 8419, 3, 3409, 28964, 8419, 12, 19764, 13, 2032, 2288, 10414, 6966, 13645, 1956, 43, 7266, 13058, 2199, 23854, 11072, 8419, 3170, 18, 1920, 2481, 3]}, "items": [{"id": "p_501", "content": "Benzylisoquinolines [SEP] ISOQUINOLINES with a benzyl substituent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17605, 23854, 11072, 8419, 1036, 3, 4911, 11072, 8419, 1036, 1956, 43, 17605, 23709, 18, 3]}]}
{"query": {"id": "q_502", "content": "thrombosis [SEP] n to investigate the effects of TET and FAN on the experimental thrombosis induced by collagen plus epinephrine (EP) in mice, and platelet", "tokenized_content": [2, 11354, 3, 56, 1942, 4482, 1920, 2564, 1927, 9717, 1930, 19764, 1990, 1920, 3599, 11354, 2719, 2007, 5621, 5390, 19280, 12, 2630, 13, 1922, 2518, 16, 1930, 7163, 3]}, "items": [{"id": "p_502", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_503", "content": "epinephrine [SEP] and FAN on the experimental thrombosis induced by collagen plus epinephrine (EP) in mice, and platelet aggregation and blood coagulation in", "tokenized_content": [2, 19280, 3, 1930, 19764, 1990, 1920, 3599, 11354, 2719, 2007, 5621, 5390, 19280, 12, 2630, 13, 1922, 2518, 16, 1930, 7163, 7883, 1930, 2877, 12441, 1922, 3]}, "items": [{"id": "p_503", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_504", "content": "EP [SEP] e experimental thrombosis induced by collagen plus epinephrine (EP) in mice, and platelet aggregation and blood coagulation in vit", "tokenized_content": [2, 2630, 3, 47, 3599, 11354, 2719, 2007, 5621, 5390, 19280, 12, 2630, 13, 1922, 2518, 16, 1930, 7163, 7883, 1930, 2877, 12441, 1922, 5208, 3]}, "items": [{"id": "p_504", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_505", "content": "platelet aggregation [SEP] rombosis induced by collagen plus epinephrine (EP) in mice, and platelet aggregation and blood coagulation in vitro. In the in vivo study, the admin", "tokenized_content": [2, 7163, 7883, 3, 15612, 29258, 1937, 2719, 2007, 5621, 5390, 19280, 12, 2630, 13, 1922, 2518, 16, 1930, 7163, 7883, 1930, 2877, 12441, 1922, 3596, 18, 1922, 1920, 1922, 3597, 3]}, "items": [{"id": "p_505", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_506", "content": "blood coagulation [SEP] gen plus epinephrine (EP) in mice, and platelet aggregation and blood coagulation in vitro. In the in vivo study, the administration (50 mg/kg, i", "tokenized_content": [2, 2877, 12441, 3, 2065, 5390, 19280, 12, 2630, 13, 1922, 2518, 16, 1930, 7163, 7883, 1930, 2877, 12441, 1922, 3596, 18, 1922, 1920, 1922, 3597, 2161, 16, 1920, 4183, 12, 3]}, "items": [{"id": "p_506", "content": "Blood Coagulation Disorders [SEP] Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of facto", "score": 1, "type": null, "tokenized_content": [2, 2877, 12441, 4414, 3, 16052, 1930, 21039, 4414, 1988, 4704, 1966, 43, 7749, 1927, 6754, 1922, 2877, 12441, 2810, 1942, 43, 5386, 1927, 2371, 1037, 3]}]}
{"query": {"id": "q_507", "content": "acetylsalicylic acid [SEP] he inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhi", "tokenized_content": [2, 6894, 23880, 1935, 14523, 2687, 3, 2234, 3523, 1927, 11354, 2007, 4288, 9, 1930, 3259, 9, 16, 2763, 16, 2679, 6894, 23880, 1935, 14523, 2687, 12, 15634, 16, 2761, 2786, 3]}, "items": [{"id": "p_507", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_508", "content": "ASA [SEP] bosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibitio", "tokenized_content": [2, 15634, 3, 16159, 1937, 2007, 4288, 9, 1930, 3259, 9, 16, 2763, 16, 2679, 6894, 23880, 1935, 14523, 2687, 12, 15634, 16, 2761, 2786, 19, 3621, 16, 51, 18, 58, 3]}, "items": [{"id": "p_508", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_509", "content": "platelet aggregations [SEP] ositive control, showed only 30% inhibition. In the vitro human platelet aggregations induced by the agonists used in tests, TET and FAN showed the i", "tokenized_content": [2, 7163, 7883, 1036, 3, 3125, 2470, 2285, 16, 2594, 2444, 2627, 9, 3523, 18, 1922, 1920, 3596, 2616, 7163, 7883, 1036, 2719, 2007, 1920, 9849, 2251, 1922, 4026, 16, 9717, 3]}, "items": [{"id": "p_509", "content": "Blood Platelet Disorders [SEP] Disorders caused by abnormalities in platelet count or function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2877, 7163, 4414, 3, 4414, 4189, 2007, 6754, 1922, 7163, 6500, 2014, 2347, 18, 3]}]}
{"query": {"id": "q_510", "content": "Gemcitabine [SEP] Gemcitabine plus vinorelbine in nonsmall cell lung carcinoma patients age 7", "tokenized_content": [2, 15696, 3, 15696, 5390, 11132, 28003, 23605, 1021, 1922, 22525, 2214, 2024, 3614, 5373, 2132, 2632, 27, 3]}, "items": [{"id": "p_510", "content": "gemcitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15696, 3, 3]}]}
{"query": {"id": "q_511", "content": "vinorelbine [SEP] Gemcitabine plus vinorelbine in nonsmall cell lung carcinoma patients age 70 years or older ", "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 15696, 5390, 11132, 28003, 23605, 1021, 1922, 22525, 2214, 2024, 3614, 5373, 2132, 2632, 3895, 2739, 2014, 4706, 3]}, "items": [{"id": "p_511", "content": "vinorelbine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 3]}]}
{"query": {"id": "q_512", "content": "nonsmall cell lung carcinoma [SEP] Gemcitabine plus vinorelbine in nonsmall cell lung carcinoma patients age 70 years or older or patients who cannot receive c", "tokenized_content": [2, 22525, 2214, 2024, 3614, 5373, 3, 15696, 5390, 11132, 28003, 23605, 1021, 1922, 22525, 2214, 2024, 3614, 5373, 2132, 2632, 3895, 2739, 2014, 4706, 2014, 2132, 2746, 5156, 7130, 45, 3]}, "items": [{"id": "p_512", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_513", "content": "cisplatin [SEP] a patients age 70 years or older or patients who cannot receive cisplatin. Oncopaz Cooperative Group.", "tokenized_content": [2, 9284, 3, 43, 2132, 2632, 3895, 2739, 2014, 4706, 2014, 2132, 2746, 5156, 7130, 9284, 18, 25601, 3408, 13350, 2210, 18, 3]}, "items": [{"id": "p_513", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_514", "content": "nonsmall cell lung carcinoma [SEP] BACKGROUND: Although the prevalence of nonsmall cell lung carcinoma (NSCLC) is high among elderly patients, few data are available ", "tokenized_content": [2, 22525, 2214, 2024, 3614, 5373, 3, 3872, 30, 2876, 1920, 4077, 1927, 22525, 2214, 2024, 3614, 5373, 12, 9298, 13, 1977, 2149, 2706, 7354, 2132, 16, 3855, 2230, 2032, 3322, 3]}, "items": [{"id": "p_514", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_515", "content": "NSCLC [SEP] ROUND: Although the prevalence of nonsmall cell lung carcinoma (NSCLC) is high among elderly patients, few data are available regardi", "tokenized_content": [2, 9298, 3, 7464, 30, 2876, 1920, 4077, 1927, 22525, 2214, 2024, 3614, 5373, 12, 9298, 13, 1977, 2149, 2706, 7354, 2132, 16, 3855, 2230, 2032, 3322, 4623, 1033, 3]}, "items": [{"id": "p_515", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_516", "content": "toxicity [SEP] rly patients, few data are available regarding the efficacy and toxicity of chemotherapy in this group of patients. Recent reports indic", "tokenized_content": [2, 5532, 3, 11929, 1012, 2132, 16, 3855, 2230, 2032, 3322, 4667, 1920, 4348, 1930, 5532, 1927, 5318, 1922, 2052, 2210, 1927, 2132, 18, 3505, 4710, 2414, 3]}, "items": [{"id": "p_516", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_517", "content": "vinorelbine [SEP] atients. Recent reports indicate that single agent therapy with vinorelbine (VNB) or gemcitabine (GEM) may obtain a response rate of 20-30%", "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 2019, 6746, 18, 3505, 4710, 3579, 1988, 2957, 5899, 3181, 1956, 11132, 28003, 23605, 1021, 12, 18155, 1014, 13, 2014, 15696, 12, 10607, 13, 2278, 3]}, "items": [{"id": "p_517", "content": "vinorelbine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 3]}]}
{"query": {"id": "q_518", "content": "VNB [SEP] nt reports indicate that single agent therapy with vinorelbine (VNB) or gemcitabine (GEM) may obtain a response rate of 20-30% in e", "tokenized_content": [2, 18155, 1014, 3, 5891, 4710, 3579, 1988, 2957, 5899, 3181, 1956, 11132, 28003, 23605, 1021, 12, 18155, 1014, 13, 2014, 15696, 12, 10607, 13, 2278, 5649, 43, 2644, 2769, 1927, 3]}, "items": [{"id": "p_518", "content": "vinorelbine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 3]}]}
{"query": {"id": "q_519", "content": "gemcitabine [SEP] ts indicate that single agent therapy with vinorelbine (VNB) or gemcitabine (GEM) may obtain a response rate of 20-30% in elderly patients,", "tokenized_content": [2, 15696, 3, 4894, 3579, 1988, 2957, 5899, 3181, 1956, 11132, 28003, 23605, 1021, 12, 18155, 1014, 13, 2014, 15696, 12, 10607, 13, 2278, 5649, 43, 2644, 2769, 1927, 2036, 17, 3]}, "items": [{"id": "p_519", "content": "gemcitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15696, 3, 3]}]}
{"query": {"id": "q_520", "content": "GEM [SEP] hat single agent therapy with vinorelbine (VNB) or gemcitabine (GEM) may obtain a response rate of 20-30% in elderly patients, with", "tokenized_content": [2, 10607, 3, 16133, 2957, 5899, 3181, 1956, 11132, 28003, 23605, 1021, 12, 18155, 1014, 13, 2014, 15696, 12, 10607, 13, 2278, 5649, 43, 2644, 2769, 1927, 2036, 17, 2627, 9, 3]}, "items": [{"id": "p_520", "content": "gemcitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15696, 3, 3]}]}
{"query": {"id": "q_521", "content": "cisplatin [SEP] advanced NSCLC or those with some contraindication to receiving cisplatin were assessed. METHODS: Forty-nine patients with advanced NSCLC", "tokenized_content": [2, 9284, 3, 5570, 9298, 2014, 2690, 1956, 2673, 17825, 2959, 1942, 5962, 9284, 1985, 3683, 18, 2860, 30, 11270, 17, 6360, 2132, 1956, 5570, 9298, 3]}, "items": [{"id": "p_521", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_522", "content": "Toxicity [SEP]  progression was 16 weeks and the 1-year survival rate was 33%. Toxicity was mild. Six patients (12%) had World Health Organization Grad", "tokenized_content": [2, 5532, 3, 4380, 1982, 2641, 3625, 1930, 1920, 21, 17, 2476, 3298, 2769, 1982, 3401, 9, 18, 5532, 1982, 5809, 18, 3798, 2132, 12, 2369, 9, 13, 2430, 4867, 2436, 3]}, "items": [{"id": "p_522", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_523", "content": "neutropenia [SEP] ild. Six patients (12%) had World Health Organization Grade 3-4 neutropenia, 2 patients (4%) had Grade 3-4 thrombocytopenia, and 2 patients", "tokenized_content": [2, 18005, 3, 25220, 18, 3798, 2132, 12, 2369, 9, 13, 2430, 4867, 2436, 5901, 4927, 23, 17, 24, 18005, 16, 22, 2132, 12, 24, 9, 13, 2430, 4927, 23, 17, 3]}, "items": [{"id": "p_523", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_524", "content": "thrombocytopenia [SEP] ganization Grade 3-4 neutropenia, 2 patients (4%) had Grade 3-4 thrombocytopenia, and 2 patients (4%) had Grade 3 neurotoxicity. Three patients ", "tokenized_content": [2, 17100, 3, 16249, 2466, 4927, 23, 17, 24, 18005, 16, 22, 2132, 12, 24, 9, 13, 2430, 4927, 23, 17, 24, 17100, 16, 1930, 22, 2132, 12, 24, 9, 13, 3]}, "items": [{"id": "p_524", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_525", "content": "neurotoxicity [SEP] had Grade 3-4 thrombocytopenia, and 2 patients (4%) had Grade 3 neurotoxicity. Three patients with severe neutropenia (6%) died of sepsis. Th", "tokenized_content": [2, 18034, 3, 2430, 4927, 23, 17, 24, 17100, 16, 1930, 22, 2132, 12, 24, 9, 13, 2430, 4927, 23, 18034, 18, 2559, 2132, 1956, 4010, 18005, 12, 26, 9, 13, 3]}, "items": [{"id": "p_525", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_526", "content": "sepsis [SEP] rotoxicity. Three patients with severe neutropenia (6%) died of sepsis. The median age of those patients developing Grade 3-4 neutrope", "tokenized_content": [2, 9019, 3, 5337, 14916, 18, 2559, 2132, 1956, 4010, 18005, 12, 26, 9, 13, 8545, 1927, 9019, 18, 1920, 4181, 2632, 1927, 2690, 2132, 5130, 4927, 23, 17, 24, 16286, 3]}, "items": [{"id": "p_526", "content": "Sepsis [SEP] Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dys", "score": 1, "type": null, "tokenized_content": [2, 9019, 3, 5510, 3769, 2644, 4741, 1956, 43, 9253, 2014, 9407, 7465, 10383, 18, 2469, 9019, 1977, 2458, 1956, 3090, 3890, 3]}]}
{"query": {"id": "q_527", "content": "myelosuppression [SEP] ients age >/= 75 years. This age group had an increased risk of myelosuppression. Therefore the prophylactic use of granulocyte-colony stimulati", "tokenized_content": [2, 5707, 1951, 3481, 3124, 3, 10116, 4905, 1036, 2632, 34, 19, 33, 4089, 2739, 18, 2052, 2632, 2210, 2430, 1925, 2502, 2565, 1927, 5707, 1951, 3481, 3124, 18, 2955, 1920, 3]}, "items": [{"id": "p_527", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_528", "content": "Warfarin [SEP] Warfarin-induced artery calcification is accelerated by growth and vitam", "tokenized_content": [2, 16170, 3, 16170, 17, 2719, 5511, 14640, 1977, 10843, 2007, 2905, 1930, 5208, 1976, 3]}, "items": [{"id": "p_528", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_529", "content": "artery calcification [SEP] Warfarin-induced artery calcification is accelerated by growth and vitamin D.", "tokenized_content": [2, 5511, 14640, 3, 16170, 17, 2719, 5511, 14640, 1977, 10843, 2007, 2905, 1930, 6111, 46, 18, 3]}, "items": [{"id": "p_529", "content": "Vascular Calcification [SEP] Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROT", "score": 1, "type": null, "tokenized_content": [2, 4541, 14640, 3, 7860, 1927, 5016, 2460, 1920, 2877, 8072, 4061, 18, 9122, 14640, 1927, 1920, 7208, 2032, 2458, 1956, 8045, 1991, 3]}]}
{"query": {"id": "q_530", "content": "vitamin D [SEP] farin-induced artery calcification is accelerated by growth and vitamin D.", "tokenized_content": [2, 6111, 46, 3, 5108, 1921, 17, 2719, 5511, 14640, 1977, 10843, 2007, 2905, 1930, 6111, 46, 18, 3]}, "items": [{"id": "p_530", "content": "Vitamin D [SEP] A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS ", "score": 1, "type": null, "tokenized_content": [2, 6111, 46, 3, 43, 6111, 1988, 5921, 2321, 17177, 8515, 3236, 3706, 1930, 11949, 5000, 3349, 2070, 3706, 16, 2154, 2162, 1920, 3059, 2495, 1927, 8444, 2014, 22700, 19507, 3441, 3]}]}
{"query": {"id": "q_531", "content": "vitamin D [SEP] The present studies demonstrate that growth and vitamin D treatment enhance the extent of artery calcification in rats gi", "tokenized_content": [2, 6111, 46, 3, 1920, 2481, 2351, 4504, 1988, 2905, 1930, 6111, 46, 2311, 4826, 1920, 5064, 1927, 5511, 14640, 1922, 3615, 7217, 3]}, "items": [{"id": "p_531", "content": "Vitamin D [SEP] A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS ", "score": 1, "type": null, "tokenized_content": [2, 6111, 46, 3, 43, 6111, 1988, 5921, 2321, 17177, 8515, 3236, 3706, 1930, 11949, 5000, 3349, 2070, 3706, 16, 2154, 2162, 1920, 3059, 2495, 1927, 8444, 2014, 22700, 19507, 3441, 3]}]}
{"query": {"id": "q_532", "content": "artery calcification [SEP] trate that growth and vitamin D treatment enhance the extent of artery calcification in rats given sufficient doses of Warfarin to inhibit gamma-car", "tokenized_content": [2, 5511, 14640, 3, 3390, 2057, 1988, 2905, 1930, 6111, 46, 2311, 4826, 1920, 5064, 1927, 5511, 14640, 1922, 3615, 3258, 5409, 5312, 1927, 16170, 1942, 2875, 7034, 17, 2279, 3]}, "items": [{"id": "p_532", "content": "Vascular Calcification [SEP] Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROT", "score": 1, "type": null, "tokenized_content": [2, 4541, 14640, 3, 7860, 1927, 5016, 2460, 1920, 2877, 8072, 4061, 18, 9122, 14640, 1927, 1920, 7208, 2032, 2458, 1956, 8045, 1991, 3]}]}
{"query": {"id": "q_533", "content": "Warfarin [SEP] xtent of artery calcification in rats given sufficient doses of Warfarin to inhibit gamma-carboxylation of matrix Gla protein, a calcifi", "tokenized_content": [2, 16170, 3, 23068, 1939, 1927, 5511, 14640, 1922, 3615, 3258, 5409, 5312, 1927, 16170, 1942, 2875, 7034, 17, 9943, 1943, 1927, 4526, 27494, 2213, 16, 43, 2799, 1974, 1033, 3]}, "items": [{"id": "p_533", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_534", "content": "calcification [SEP] hat growth and vitamin D treatment enhance the extent of artery calcification in rats given sufficient doses of Warfarin to inhibit gamma-car", "tokenized_content": [2, 14640, 3, 16133, 2905, 1930, 6111, 46, 2311, 4826, 1920, 5064, 1927, 5511, 14640, 1922, 3615, 3258, 5409, 5312, 1927, 16170, 1942, 2875, 7034, 17, 2279, 3]}, "items": [{"id": "p_534", "content": "Calcinosis [SEP] Pathologic deposition of calcium salts in tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2799, 11096, 1937, 3, 11896, 7860, 1927, 5016, 16028, 1922, 3878, 18, 3]}]}
{"query": {"id": "q_535", "content": "calcification of the artery [SEP]  rats. Treatment for 2 weeks with Warfarin caused massive focal calcification of the artery media in 20-day-old rats and less extensive focal calcification", "tokenized_content": [2, 14640, 1927, 1920, 5511, 3, 3615, 18, 2311, 1958, 22, 3625, 1956, 16170, 4189, 12944, 8083, 14640, 1927, 1920, 5511, 4996, 1922, 2036, 17, 3007, 17, 4156, 3615, 1930, 2941, 3]}, "items": [{"id": "p_535", "content": "Vascular Calcification [SEP] Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROT", "score": 1, "type": null, "tokenized_content": [2, 4541, 14640, 3, 7860, 1927, 5016, 2460, 1920, 2877, 8072, 4061, 18, 9122, 14640, 1927, 1920, 7208, 2032, 2458, 1956, 8045, 1991, 3]}]}
{"query": {"id": "q_536", "content": "phosphate [SEP] he present study, there was a relationship between higher serum phosphate and susceptibility to artery calcification, with 30% higher lev", "tokenized_content": [2, 5413, 3, 2234, 2481, 2161, 16, 2276, 1982, 43, 3303, 2192, 2580, 3256, 5413, 1930, 6461, 1942, 5511, 14640, 16, 1956, 2627, 9, 2580, 10157, 3]}, "items": [{"id": "p_536", "content": "Phosphates [SEP] Inorganic salts of phosphoric acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26473, 3, 13849, 16028, 1927, 3421, 1935, 2687, 18, 3]}]}
{"query": {"id": "q_537", "content": "vitamin K [SEP] the artery media in as little as 3 to 4 days. High doses of the vitamin K antagonist Warfarin are also known to cause calcification of th", "tokenized_content": [2, 6111, 53, 3, 1920, 5511, 4996, 1922, 1966, 5082, 1966, 23, 1942, 24, 3000, 18, 2149, 5312, 1927, 1920, 6111, 53, 8151, 16170, 2032, 2222, 3171, 1942, 3936, 14640, 1927, 3]}, "items": [{"id": "p_537", "content": "Vitamin K [SEP] A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phyto", "score": 1, "type": null, "tokenized_content": [2, 6111, 53, 3, 43, 4486, 15155, 1988, 1977, 3414, 1958, 2791, 2877, 23625, 18, 2980, 4952, 1927, 6111, 53, 2162, 2252, 2899, 30, 6111, 53, 21, 12, 25512, 3]}]}
{"query": {"id": "q_538", "content": "calcium [SEP] tion and the effect of vitamin D dose on the elevation of serum calcium, which suggests that vitamin D may induce artery calcification ", "tokenized_content": [2, 5016, 3, 8685, 1916, 1930, 1920, 2495, 1927, 6111, 46, 3253, 1990, 1920, 8644, 1927, 3256, 5016, 16, 2154, 4015, 1988, 6111, 46, 2278, 4769, 5511, 14640, 3]}, "items": [{"id": "p_538", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_539", "content": "gamma-carboxylated [SEP] nalysis showed that the protein that accumulated was indeed not gamma-carboxylated. These observations indicate that although the gamma-carboxyglu", "tokenized_content": [2, 7034, 17, 20877, 1007, 3, 13120, 4662, 2594, 1988, 1920, 2213, 1988, 10508, 1982, 5087, 2084, 7034, 17, 20877, 1007, 18, 2144, 5184, 3579, 1988, 2876, 1920, 7034, 17, 15750, 3]}, "items": [{"id": "p_539", "content": "1-Carboxyglutamic Acid [SEP] Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 15750, 16542, 13514, 2687, 3, 2435, 1922, 3425, 3878, 16, 4443, 1922, 3006, 2877, 17, 23625, 2697, 2710, 23976, 16, 1922, 5245, 2213, 16, 1922, 3622, 2213, 3]}]}
{"query": {"id": "q_540", "content": "gamma-carboxyglutamate [SEP] mma-carboxylated. These observations indicate that although the gamma-carboxyglutamate residues of matrix Gla protein are apparently required for its ", "tokenized_content": [2, 7034, 17, 15750, 16542, 21084, 3, 29025, 17, 20877, 1007, 18, 2144, 5184, 3579, 1988, 2876, 1920, 7034, 17, 15750, 16542, 21084, 4248, 1927, 4526, 27494, 2213, 2032, 10535, 3414, 3]}, "items": [{"id": "p_540", "content": "1-Carboxyglutamic Acid [SEP] Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 15750, 16542, 13514, 2687, 3, 2435, 1922, 3425, 3878, 16, 4443, 1922, 3006, 2877, 17, 23625, 2697, 2710, 23976, 16, 1922, 5245, 2213, 16, 1922, 3622, 2213, 3]}]}
{"query": {"id": "q_541", "content": "Antidepressant [SEP] Antidepressant-induced mania in bipolar patients: identification of risk facto", "tokenized_content": [2, 14183, 3, 14183, 17, 2719, 28864, 1922, 10275, 2132, 30, 4824, 1927, 2565, 2371, 1037, 3]}, "items": [{"id": "p_541", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_542", "content": "mania [SEP] Antidepressant-induced mania in bipolar patients: identification of risk factors.", "tokenized_content": [2, 28864, 3, 14183, 17, 2719, 28864, 1922, 10275, 2132, 30, 4824, 1927, 2565, 2790, 18, 3]}, "items": [{"id": "p_542", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_543", "content": "bipolar [SEP] Antidepressant-induced mania in bipolar patients: identification of risk factors.", "tokenized_content": [2, 10275, 3, 14183, 17, 2719, 28864, 1922, 10275, 2132, 30, 4824, 1927, 2565, 2790, 18, 3]}, "items": [{"id": "p_543", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_544", "content": "mania [SEP] BACKGROUND: Concerns about possible risks of switching to mania associated with antidepressants continue to interfere with the ", "tokenized_content": [2, 28864, 3, 3872, 30, 8103, 3001, 3216, 7481, 1927, 10880, 1942, 28864, 2458, 1956, 17722, 9085, 1942, 11827, 1956, 1920, 3]}, "items": [{"id": "p_544", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_545", "content": "antidepressants [SEP] erns about possible risks of switching to mania associated with antidepressants continue to interfere with the establishment of an optimal trea", "tokenized_content": [2, 17722, 3, 29681, 1036, 3001, 3216, 7481, 1927, 10880, 1942, 28864, 2458, 1956, 17722, 9085, 1942, 11827, 1956, 1920, 11108, 1927, 1925, 5419, 2171, 1019, 3]}, "items": [{"id": "p_545", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_546", "content": "bipolar depression [SEP] ere with the establishment of an optimal treatment paradigm for bipolar depression. METHOD: The response of 44 patients meeting DSM-IV criteria fo", "tokenized_content": [2, 10275, 4621, 3, 22561, 1956, 1920, 11108, 1927, 1925, 5419, 2311, 9930, 1958, 10275, 4621, 18, 2417, 30, 1920, 2644, 1927, 4044, 2132, 8957, 10964, 17, 4370, 4164, 5917, 3]}, "items": [{"id": "p_546", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_547", "content": "bipolar disorder [SEP] METHOD: The response of 44 patients meeting DSM-IV criteria for bipolar disorder to naturalistic treatment was assessed for at least 6 weeks usi", "tokenized_content": [2, 10275, 4770, 3, 2417, 30, 1920, 2644, 1927, 4044, 2132, 8957, 10964, 17, 4370, 4164, 1958, 10275, 4770, 1942, 4613, 4036, 2311, 1982, 3683, 1958, 2019, 3464, 26, 3625, 2022, 3]}, "items": [{"id": "p_547", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_548", "content": "manic [SEP] e Bech-Rafaelson Mania Rating Scale. Patients who experienced a manic or hypomanic switch were compared with those who did not on sev", "tokenized_content": [2, 2323, 1935, 3, 47, 2605, 1023, 17, 12783, 14169, 5810, 28864, 7276, 3536, 18, 2132, 2746, 6090, 43, 2323, 1935, 2014, 22750, 19510, 6195, 1985, 2452, 1956, 2690, 2746, 2811, 3]}, "items": [{"id": "p_548", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_549", "content": "hypomanic [SEP] faelson Mania Rating Scale. Patients who experienced a manic or hypomanic switch were compared with those who did not on several variable", "tokenized_content": [2, 22750, 19510, 3, 5685, 19559, 28864, 7276, 3536, 18, 2132, 2746, 6090, 43, 2323, 1935, 2014, 22750, 19510, 6195, 1985, 2452, 1956, 2690, 2746, 2811, 2084, 1990, 2980, 4650, 3]}, "items": [{"id": "p_549", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_550", "content": "DSM-IV bipolar I [SEP] who did not on several variables including age, sex, diagnosis (DSM-IV bipolar I vs. bipolar II), number of previous manic episodes, type of ant", "tokenized_content": [2, 10964, 17, 4370, 10275, 51, 3, 2746, 2811, 2084, 1990, 2980, 3832, 2710, 2632, 16, 3486, 16, 3574, 12, 10964, 17, 4370, 10275, 51, 3201, 18, 10275, 2890, 13, 16, 3]}, "items": [{"id": "p_550", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_551", "content": "bipolar II [SEP] l variables including age, sex, diagnosis (DSM-IV bipolar I vs. bipolar II), number of previous manic episodes, type of antidepressant the", "tokenized_content": [2, 10275, 2890, 3, 54, 3832, 2710, 2632, 16, 3486, 16, 3574, 12, 10964, 17, 4370, 10275, 51, 3201, 18, 10275, 2890, 13, 16, 2529, 1927, 2555, 2323, 1935, 9232, 16, 3]}, "items": [{"id": "p_551", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_552", "content": "antidepressant [SEP] erns about possible risks of switching to mania associated with antidepressants continue to interfere with the establishment of an optimal tre", "tokenized_content": [2, 14183, 3, 29681, 1036, 3001, 3216, 7481, 1927, 10880, 1942, 28864, 2458, 1956, 17722, 9085, 1942, 11827, 1956, 1920, 11108, 1927, 1925, 5419, 2171, 3]}, "items": [{"id": "p_552", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_553", "content": "serotonin reuptake inhibitors [SEP] rapy vs. antidepressant drugs and, more particularly, selective serotonin reuptake inhibitors [SSRIs]), use and type of mood stabilizers (lithium vs. anticon", "tokenized_content": [2, 11153, 22957, 4472, 3, 3694, 1012, 3201, 18, 14183, 4195, 1930, 16, 2253, 4443, 16, 5328, 11153, 22957, 4472, 37, 29395, 39, 13, 16, 2485, 1930, 2601, 1927, 9494, 13448, 3]}, "items": [{"id": "p_553", "content": "Serotonin Uptake Inhibitors [SEP] Compounds that specifically inhibit the reuptake of serotonin in the brain.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11153, 5047, 4472, 3, 4300, 1988, 4475, 2875, 1920, 22957, 1927, 11153, 1922, 1920, 3068, 18, 3]}]}
{"query": {"id": "q_554", "content": "SSRIs [SEP] nd, more particularly, selective serotonin reuptake inhibitors [SSRIs]), use and type of mood stabilizers (lithium vs. anticonvulsant", "tokenized_content": [2, 29395, 3, 8026, 16, 2253, 4443, 16, 5328, 11153, 22957, 4472, 37, 29395, 39, 13, 16, 2485, 1930, 2601, 1927, 9494, 13448, 5675, 12, 14330, 3201, 18, 26572, 2031, 3]}, "items": [{"id": "p_554", "content": "Serotonin Uptake Inhibitors [SEP] Compounds that specifically inhibit the reuptake of serotonin in the brain.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11153, 5047, 4472, 3, 4300, 1988, 4475, 2875, 1920, 22957, 1927, 11153, 1922, 1920, 3068, 18, 3]}]}
{"query": {"id": "q_555", "content": "lithium [SEP] reuptake inhibitors [SSRIs]), use and type of mood stabilizers (lithium vs. anticonvulsants), and temperament of the patient, assessed ", "tokenized_content": [2, 14330, 3, 22957, 4472, 37, 29395, 39, 13, 16, 2485, 1930, 2601, 1927, 9494, 13448, 5675, 12, 14330, 3201, 18, 26572, 2356, 13, 16, 1930, 24432, 1927, 1920, 2774, 16, 3]}, "items": [{"id": "p_555", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_556", "content": "hypomania [SEP] tructured Affective Temperament Interview. RESULTS: Switches to hypomania or mania occurred in 27% of all patients (N = 12) (and in 24% o", "tokenized_content": [2, 22750, 12231, 3, 2025, 8780, 3510, 11863, 24432, 5132, 18, 2274, 30, 21529, 1942, 22750, 12231, 2014, 28864, 4807, 1922, 3225, 9, 1927, 2136, 2132, 12, 56, 33, 2369, 13, 3]}, "items": [{"id": "p_556", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_557", "content": "bipolar I [SEP]  not on several variables including age, sex, diagnosis (DSM-IV bipolar I vs. bipolar II), number of previous manic episodes, type of ant", "tokenized_content": [2, 10275, 51, 3, 2084, 1990, 2980, 3832, 2710, 2632, 16, 3486, 16, 3574, 12, 10964, 17, 4370, 10275, 51, 3201, 18, 10275, 2890, 13, 16, 2529, 1927, 2555, 2323, 1935, 3]}, "items": [{"id": "p_557", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_558", "content": "Caffeine [SEP] Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfoo", "tokenized_content": [2, 14119, 3, 14119, 17, 2719, 4435, 18346, 30, 1925, 24983, 3495, 15378, 1927, 2436, 15282, 1037, 3]}, "items": [{"id": "p_558", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_559", "content": "cardiac arrhythmia [SEP] Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products.", "tokenized_content": [2, 4435, 18346, 3, 14119, 17, 2719, 4435, 18346, 30, 1925, 24983, 3495, 15378, 1927, 2436, 15282, 1986, 4461, 18, 3]}, "items": [{"id": "p_559", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_560", "content": "mitral valve prolapse [SEP] We describe a 25-year-old woman with pre-existing mitral valve prolapse who developed intractable ventricular fibrillation after consum", "tokenized_content": [2, 13868, 9509, 24401, 3, 2038, 5993, 43, 2637, 17, 2476, 17, 4156, 10440, 1956, 2097, 17, 6124, 13868, 9509, 24401, 2746, 3530, 26032, 6493, 13671, 2256, 4278, 3]}, "items": [{"id": "p_560", "content": "Mitral Valve Prolapse [SEP] Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows", "score": 1, "type": null, "tokenized_content": [2, 13868, 9509, 24401, 3, 4552, 24384, 2014, 11376, 1971, 1941, 1927, 2340, 2014, 2321, 1927, 1920, 27269, 1927, 13868, 9509, 2460, 1920, 3506, 20548, 2409, 8055, 2456, 18, 2052, 5731, 3]}]}
{"query": {"id": "q_561", "content": "ventricular fibrillation [SEP] th pre-existing mitral valve prolapse who developed intractable ventricular fibrillation after consuming a \"natural energy\" guarana health drink contain", "tokenized_content": [2, 6493, 13671, 3, 1913, 2097, 17, 6124, 13868, 9509, 24401, 2746, 3530, 26032, 6493, 13671, 2256, 12359, 43, 6, 4613, 3844, 6, 14067, 7241, 2436, 6045, 5531, 3]}, "items": [{"id": "p_561", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_562", "content": "caffeine [SEP] energy\" guarana health drink containing a high concentration of caffeine. This case highlights the need for adequate labelling and regul", "tokenized_content": [2, 14119, 3, 3844, 6, 14067, 7241, 2436, 6045, 3165, 43, 2149, 3110, 1927, 14119, 18, 2052, 3087, 10668, 1920, 2942, 1958, 7485, 16213, 1930, 3052, 3]}, "items": [{"id": "p_562", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_563", "content": "retention of urine [SEP] Bladder retention of urine as a result of continuous intravenous infusion of fentanyl: 2 c", "tokenized_content": [2, 7521, 1927, 6960, 3, 7821, 7521, 1927, 6960, 1966, 43, 3211, 1927, 4798, 7307, 7386, 1927, 20311, 30, 22, 45, 3]}, "items": [{"id": "p_563", "content": "Urinary Retention [SEP] Inability to empty the URINARY BLADDER with voiding (URINATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7521, 3, 11752, 1942, 10494, 1920, 7075, 7821, 1956, 27682, 12, 3674, 2636, 13, 18, 3]}]}
{"query": {"id": "q_564", "content": "fentanyl [SEP] tion of urine as a result of continuous intravenous infusion of fentanyl: 2 case reports.", "tokenized_content": [2, 20311, 3, 8685, 1916, 1927, 6960, 1966, 43, 3211, 1927, 4798, 7307, 7386, 1927, 20311, 30, 22, 3087, 4710, 18, 3]}, "items": [{"id": "p_564", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_565", "content": "pain [SEP] as been commonly used in the neonate to decrease the stress and pain from the noxious stimuli and invasive procedures in the neonata", "tokenized_content": [2, 3594, 3, 1966, 2252, 5384, 2251, 1922, 1920, 27586, 1942, 3714, 1920, 3071, 1930, 3594, 2037, 1920, 24218, 5458, 1930, 6044, 4869, 1922, 1920, 6621, 5499, 3]}, "items": [{"id": "p_565", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_566", "content": "Fentanyl [SEP] acilitate synchrony between ventilator and spontaneous breaths. Fentanyl, an opioid analgesic, is frequently used in the neonatal intens", "tokenized_content": [2, 20311, 3, 2000, 5912, 3857, 2057, 21466, 2192, 21167, 1930, 6242, 8735, 1036, 18, 20311, 16, 1925, 9384, 14501, 16, 1977, 5467, 2251, 1922, 1920, 7985, 14449, 3]}, "items": [{"id": "p_566", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_567", "content": "fentanyl [SEP] tting for these very purposes. Various reported side effects of fentanyl administration include chest wall rigidity, hypotension, respir", "tokenized_content": [2, 20311, 3, 7382, 1941, 1958, 2144, 3345, 9323, 18, 3425, 2568, 4159, 2564, 1927, 20311, 4183, 3951, 8475, 4821, 20471, 16, 16453, 16, 4962, 3]}, "items": [{"id": "p_567", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_568", "content": "chest wall rigidity [SEP] arious reported side effects of fentanyl administration include chest wall rigidity, hypotension, respiratory depression, and bradycardia. Here, 2 ", "tokenized_content": [2, 8475, 4821, 20471, 3, 27950, 2080, 2568, 4159, 2564, 1927, 20311, 4183, 3951, 8475, 4821, 20471, 16, 16453, 16, 5481, 4621, 16, 1930, 26192, 18, 3410, 16, 22, 3]}, "items": [{"id": "p_568", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_569", "content": "hypotension [SEP] effects of fentanyl administration include chest wall rigidity, hypotension, respiratory depression, and bradycardia. Here, 2 cases of urin", "tokenized_content": [2, 16453, 3, 2564, 1927, 20311, 4183, 3951, 8475, 4821, 20471, 16, 16453, 16, 5481, 4621, 16, 1930, 26192, 18, 3410, 16, 22, 2919, 1927, 3674, 1921, 3]}, "items": [{"id": "p_569", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_570", "content": "respiratory depression [SEP] ntanyl administration include chest wall rigidity, hypotension, respiratory depression, and bradycardia. Here, 2 cases of urinary bladder retention le", "tokenized_content": [2, 5481, 4621, 3, 20503, 16323, 1024, 4183, 3951, 8475, 4821, 20471, 16, 16453, 16, 5481, 4621, 16, 1930, 26192, 18, 3410, 16, 22, 2919, 1927, 7075, 7821, 7521, 2071, 3]}, "items": [{"id": "p_570", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_571", "content": "bradycardia [SEP] e chest wall rigidity, hypotension, respiratory depression, and bradycardia. Here, 2 cases of urinary bladder retention leading to renal pe", "tokenized_content": [2, 26192, 3, 47, 8475, 4821, 20471, 16, 16453, 16, 5481, 4621, 16, 1930, 26192, 18, 3410, 16, 22, 2919, 1927, 7075, 7821, 7521, 4523, 1942, 4604, 2737, 3]}, "items": [{"id": "p_571", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_572", "content": "urinary bladder retention [SEP] sion, respiratory depression, and bradycardia. Here, 2 cases of urinary bladder retention leading to renal pelvocalyceal dilatation mimicking hydronephro", "tokenized_content": [2, 7075, 7821, 7521, 3, 5998, 1916, 16, 5481, 4621, 16, 1930, 26192, 18, 3410, 16, 22, 2919, 1927, 7075, 7821, 7521, 4523, 1942, 4604, 7874, 15525, 5657, 2773, 5243, 17799, 3]}, "items": [{"id": "p_572", "content": "Urinary Bladder Diseases [SEP] Pathological processes of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 3902, 3, 6598, 4028, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_573", "content": "hydronephrosis [SEP] r retention leading to renal pelvocalyceal dilatation mimicking hydronephrosis as a result of continuous infusion of fentanyl are reported.", "tokenized_content": [2, 3290, 2912, 2102, 4870, 3, 60, 7521, 4523, 1942, 4604, 7874, 15525, 5657, 2773, 5243, 17799, 18072, 3290, 2912, 2102, 4870, 1966, 43, 3211, 1927, 4798, 7386, 1927, 20311, 2032, 3]}, "items": [{"id": "p_573", "content": "Hydronephrosis [SEP] Abnormal enlargement or swelling of a KIDNEY due to dilation of the KIDNEY CALICES and the KIDNEY PELVIS. It is often associated", "score": 1, "type": null, "tokenized_content": [2, 3290, 2912, 2102, 4870, 3, 4552, 16363, 2014, 11438, 1927, 43, 5245, 2810, 1942, 16470, 1927, 1920, 5245, 2570, 3590, 1930, 1920, 5245, 18152, 18, 2176, 1977, 3868, 2458, 3]}]}
{"query": {"id": "q_574", "content": "cardiomyopathy [SEP] Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice.", "tokenized_content": [2, 14141, 3, 4252, 14255, 3181, 5092, 14141, 1930, 27565, 1036, 3582, 9456, 1922, 6309, 8494, 2518, 18, 3]}, "items": [{"id": "p_574", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_575", "content": "lactate [SEP] ntiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice.", "tokenized_content": [2, 9456, 3, 5891, 2952, 1997, 20165, 3181, 5092, 14141, 1930, 27565, 1036, 3582, 9456, 1922, 6309, 8494, 2518, 18, 3]}, "items": [{"id": "p_575", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_576", "content": "AIDS [SEP] causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice.", "tokenized_content": [2, 8494, 3, 5092, 14141, 1930, 27565, 1036, 3582, 9456, 1922, 6309, 8494, 2518, 18, 3]}, "items": [{"id": "p_576", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_577", "content": "cardiomyopathy [SEP] Highly active antiretroviral therapy (HAART) is implicated in cardiomyopathy (CM) and in elevated plasma lactate (LA) in AIDS through mechan", "tokenized_content": [2, 14141, 3, 3626, 3500, 14255, 3181, 12, 18711, 13, 1977, 6835, 1922, 14141, 12, 3195, 13, 1930, 1922, 4664, 3582, 9456, 12, 5114, 13, 1922, 8494, 2596, 2665, 3]}, "items": [{"id": "p_577", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_578", "content": "CM [SEP] antiretroviral therapy (HAART) is implicated in cardiomyopathy (CM) and in elevated plasma lactate (LA) in AIDS through mechanisms", "tokenized_content": [2, 3195, 3, 14255, 3181, 12, 18711, 13, 1977, 6835, 1922, 14141, 12, 3195, 13, 1930, 1922, 4664, 3582, 9456, 12, 5114, 13, 1922, 8494, 2596, 3531, 3]}, "items": [{"id": "p_578", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_579", "content": "lactate [SEP] RT) is implicated in cardiomyopathy (CM) and in elevated plasma lactate (LA) in AIDS through mechanisms of mitochondrial dysfunction. T", "tokenized_content": [2, 9456, 3, 4341, 13, 1977, 6835, 1922, 14141, 12, 3195, 13, 1930, 1922, 4664, 3582, 9456, 12, 5114, 13, 1922, 8494, 2596, 3531, 1927, 4596, 5273, 18, 62, 3]}, "items": [{"id": "p_579", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_580", "content": "LA [SEP] plicated in cardiomyopathy (CM) and in elevated plasma lactate (LA) in AIDS through mechanisms of mitochondrial dysfunction. To de", "tokenized_content": [2, 5114, 3, 2123, 22171, 1922, 14141, 12, 3195, 13, 1930, 1922, 4664, 3582, 9456, 12, 5114, 13, 1922, 8494, 2596, 3531, 1927, 4596, 5273, 18, 1942, 2028, 3]}, "items": [{"id": "p_580", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_581", "content": "AIDS [SEP] d in cardiomyopathy (CM) and in elevated plasma lactate (LA) in AIDS through mechanisms of mitochondrial dysfunction. To determine m", "tokenized_content": [2, 8494, 3, 46, 1922, 14141, 12, 3195, 13, 1930, 1922, 4664, 3582, 9456, 12, 5114, 13, 1922, 8494, 2596, 3531, 1927, 4596, 5273, 18, 1942, 3415, 55, 3]}, "items": [{"id": "p_581", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_582", "content": "mitochondrial dysfunction [SEP] d in elevated plasma lactate (LA) in AIDS through mechanisms of mitochondrial dysfunction. To determine mitochondrial events from HAART in vivo, 8-week-o", "tokenized_content": [2, 4596, 5273, 3, 46, 1922, 4664, 3582, 9456, 12, 5114, 13, 1922, 8494, 2596, 3531, 1927, 4596, 5273, 18, 1942, 3415, 4596, 3916, 2037, 18711, 1922, 3597, 16, 28, 17, 3]}, "items": [{"id": "p_582", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_583", "content": "zidovudine [SEP] pe FVB/n littermates were treated with the HAART combination of zidovudine, lamivudine, and indinavir or vehicle control for 10 days or 35", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 2737, 27345, 19, 56, 16012, 1985, 2868, 1956, 1920, 18711, 3921, 1927, 28666, 22389, 1020, 20597, 16, 30208, 16, 1930, 2063, 4058, 3026, 2014, 6463, 3]}, "items": [{"id": "p_583", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_584", "content": "lamivudine [SEP] termates were treated with the HAART combination of zidovudine, lamivudine, and indinavir or vehicle control for 10 days or 35 days. At te", "tokenized_content": [2, 30208, 3, 2576, 2209, 1985, 2868, 1956, 1920, 18711, 3921, 1927, 28666, 22389, 1020, 20597, 16, 30208, 16, 1930, 2063, 4058, 3026, 2014, 6463, 2285, 1958, 2119, 3000, 2014, 3259, 3]}, "items": [{"id": "p_584", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_585", "content": "indinavir [SEP] eated with the HAART combination of zidovudine, lamivudine, and indinavir or vehicle control for 10 days or 35 days. At termination of th", "tokenized_content": [2, 2063, 4058, 3026, 3, 13619, 1919, 1956, 1920, 18711, 3921, 1927, 28666, 22389, 1020, 20597, 16, 30208, 16, 1930, 2063, 4058, 3026, 2014, 6463, 2285, 1958, 2119, 3000, 2014, 3259, 3]}, "items": [{"id": "p_585", "content": "Indinavir [SEP] A potent and specific HIV protease inhibitor that appears to have good oral bioavailability.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2063, 4058, 3026, 3, 43, 6828, 1930, 2487, 3525, 7154, 4106, 1988, 5107, 1942, 2162, 4227, 4726, 13574, 18, 3]}]}
{"query": {"id": "q_586", "content": "calcium [SEP]  mRNA encoding atrial natriuretic factor [ANF] and sarcoplasmic calcium ATPase [SERCA2]), and determination of plasma LA. Myocardial hi", "tokenized_content": [2, 5016, 3, 3616, 5797, 9224, 20434, 2991, 37, 1925, 1038, 39, 1930, 30060, 29327, 5016, 9444, 37, 23181, 1028, 39, 13, 16, 1930, 7063, 1927, 3582, 5114, 18, 6497, 10220, 3]}, "items": [{"id": "p_586", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_587", "content": "Oral contraceptives [SEP] Oral contraceptives and the risk of myocardial infarction.", "tokenized_content": [2, 4726, 25434, 3, 4726, 25434, 1930, 1920, 2565, 1927, 6497, 8358, 18, 3]}, "items": [{"id": "p_587", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_588", "content": "myocardial infarction [SEP] Oral contraceptives and the risk of myocardial infarction.", "tokenized_content": [2, 6497, 8358, 3, 4726, 25434, 1930, 1920, 2565, 1927, 6497, 8358, 18, 3]}, "items": [{"id": "p_588", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_589", "content": "oral contraceptives [SEP] BACKGROUND: An association between the use of oral contraceptives and the risk of myocardial infarction has been found in some, b", "tokenized_content": [2, 4726, 25434, 3, 3872, 30, 1925, 3279, 2192, 1920, 2485, 1927, 4726, 25434, 1930, 1920, 2565, 1927, 6497, 8358, 2258, 2252, 2435, 1922, 2673, 16, 44, 3]}, "items": [{"id": "p_589", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_590", "content": "myocardial infarction [SEP] ociation between the use of oral contraceptives and the risk of myocardial infarction has been found in some, but not all, studies. We investigated t", "tokenized_content": [2, 6497, 8358, 3, 5084, 13196, 2192, 1920, 2485, 1927, 4726, 25434, 1930, 1920, 2565, 1927, 6497, 8358, 2258, 2252, 2435, 1922, 2673, 16, 2308, 2084, 2136, 16, 2351, 18, 2038, 3]}, "items": [{"id": "p_590", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_591", "content": "progestagen [SEP] ies. We investigated this association, according to the type of progestagen included in third-generation (i.e., desogestrel or gestodene) a", "tokenized_content": [2, 10759, 3857, 2432, 3, 10116, 1036, 18, 2038, 3845, 2052, 3279, 16, 3147, 1942, 1920, 2601, 1927, 10759, 3857, 2432, 3063, 1922, 4563, 17, 4841, 12, 51, 18, 47, 18, 3]}, "items": [{"id": "p_591", "content": "Progestins [SEP] Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERON", "score": 1, "type": null, "tokenized_content": [2, 10759, 21881, 3, 4300, 1988, 6310, 1956, 11528, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 10759, 1967, 1916, 3]}]}
{"query": {"id": "q_592", "content": "desogestrel [SEP]  to the type of progestagen included in third-generation (i.e., desogestrel or gestodene) and second-generation (i.e., levonorgestrel) oral", "tokenized_content": [2, 2270, 18165, 2156, 5703, 3, 1942, 1920, 2601, 1927, 10759, 3857, 2432, 3063, 1922, 4563, 17, 4841, 12, 51, 18, 47, 18, 16, 2270, 18165, 2156, 5703, 2014, 6919, 5215, 3]}, "items": [{"id": "p_592", "content": "Desogestrel [SEP] A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2270, 18165, 2156, 5703, 3, 43, 6830, 10759, 4926, 1923, 6365, 2251, 3868, 1966, 1920, 10759, 4575, 11216, 4594, 1927, 4252, 4726, 16765, 4820, 18, 3]}]}
{"query": {"id": "q_593", "content": "gestodene [SEP]  progestagen included in third-generation (i.e., desogestrel or gestodene) and second-generation (i.e., levonorgestrel) oral contraceptiv", "tokenized_content": [2, 6919, 5215, 2912, 3, 10759, 3857, 2432, 3063, 1922, 4563, 17, 4841, 12, 51, 18, 47, 18, 16, 2270, 18165, 2156, 5703, 2014, 6919, 5215, 2912, 13, 1930, 2812, 17, 3]}, "items": [{"id": "p_593", "content": "Gestodene [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6919, 5215, 2912, 3, 3]}]}
{"query": {"id": "q_594", "content": "levonorgestrel [SEP] n (i.e., desogestrel or gestodene) and second-generation (i.e., levonorgestrel) oral contraceptives, the dose of estrogen, and the presence or", "tokenized_content": [2, 30129, 11873, 1005, 3190, 5703, 3, 56, 12, 51, 18, 47, 18, 16, 2270, 18165, 2156, 5703, 2014, 6919, 5215, 2912, 13, 1930, 2812, 17, 4841, 12, 51, 18, 47, 3]}, "items": [{"id": "p_594", "content": "Levonorgestrel [SEP] A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-", "score": 1, "type": null, "tokenized_content": [2, 30129, 11873, 1005, 3190, 5703, 3, 43, 6830, 10759, 4926, 1923, 6365, 1956, 7728, 2551, 1942, 2690, 1927, 11528, 1930, 3001, 6470, 1966, 6828, 1966, 2496, 7442, 4913, 2014, 12, 15, 17, 3]}]}
{"query": {"id": "q_595", "content": "estrogen [SEP] eration (i.e., levonorgestrel) oral contraceptives, the dose of estrogen, and the presence or absence of prothrombotic mutations METHODS", "tokenized_content": [2, 7940, 3, 14821, 1929, 12, 51, 18, 47, 18, 16, 30129, 11873, 1005, 3190, 5703, 13, 4726, 25434, 16, 1920, 3253, 1927, 7940, 16, 1930, 1920, 2990, 2014, 3905, 1927, 3]}, "items": [{"id": "p_595", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_596", "content": "oral-contraceptive [SEP]  event, and area of residence. Subjects supplied information on oral-contraceptive use and major cardiovascular risk factors. An analysis for fact", "tokenized_content": [2, 4726, 17, 16765, 3, 4817, 16, 1930, 3403, 1927, 13209, 18, 3297, 13164, 2988, 1990, 4726, 17, 16765, 2485, 1930, 3044, 5321, 2565, 2790, 18, 1925, 2333, 1958, 2371, 3]}, "items": [{"id": "p_596", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_597", "content": "oral contraceptive [SEP] BACKGROUND: An association between the use of oral contraceptives and the risk of myocardial infarction has been found in some, ", "tokenized_content": [2, 4726, 16765, 3, 3872, 30, 1925, 3279, 2192, 1920, 2485, 1927, 4726, 25434, 1930, 1920, 2565, 1927, 6497, 8358, 2258, 2252, 2435, 1922, 2673, 16, 3]}, "items": [{"id": "p_597", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_598", "content": "cocaine [SEP] or ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats.", "tokenized_content": [2, 9045, 3, 2014, 6908, 27415, 2207, 2460, 1920, 4020, 5949, 9929, 2014, 4728, 1990, 1920, 9045, 17, 2719, 13594, 15534, 1922, 3615, 18, 3]}, "items": [{"id": "p_598", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_599", "content": "locomotor hyperactivity [SEP] injected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats.", "tokenized_content": [2, 13594, 15534, 3, 5624, 2460, 1920, 4020, 5949, 9929, 2014, 4728, 1990, 1920, 9045, 17, 2719, 13594, 15534, 1922, 3615, 18, 3]}, "items": [{"id": "p_599", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_600", "content": "locomotor hyperactivity [SEP] egions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted bil", "tokenized_content": [2, 13594, 15534, 3, 7282, 2443, 1927, 1920, 5607, 19775, 12, 1920, 9929, 1930, 1920, 4728, 13, 1990, 1920, 13594, 15534, 2719, 2007, 9045, 1922, 3615, 18, 4005, 15668, 3615, 1985, 3]}, "items": [{"id": "p_600", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_601", "content": "cocaine [SEP] e shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted bilaterally with cannu", "tokenized_content": [2, 9045, 3, 47, 9929, 1930, 1920, 4728, 13, 1990, 1920, 13594, 15534, 2719, 2007, 9045, 1922, 3615, 18, 4005, 15668, 3615, 1985, 10978, 19092, 1956, 8734, 1032, 3]}, "items": [{"id": "p_601", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_602", "content": "GR 55562 [SEP] he accumbens shell or core, and then were locally injected with GR 55562 (an antagonist of 5-HT1B receptors) or CP 93129 (an agonist of ", "tokenized_content": [2, 2398, 24098, 8166, 3, 2234, 19775, 9929, 2014, 4728, 16, 1930, 2759, 1985, 10753, 5624, 1956, 2398, 24098, 8166, 12, 1925, 8151, 1927, 25, 17, 5334, 10547, 4086, 13, 2014, 3]}, "items": [{"id": "p_602", "content": "3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 12, 23, 17, 12, 9780, 19143, 13, 20299, 13, 17, 24, 17, 8275, 17, 56, 17, 12, 24, 17, 12, 24, 17, 24828, 1921, 2199, 13, 7971, 13, 7334, 5482, 3, 3]}]}
{"query": {"id": "q_603", "content": "CP 93129 [SEP] y injected with GR 55562 (an antagonist of 5-HT1B receptors) or CP 93129 (an agonist of 5-HT1B receptors). Given alone to any accumbal s", "tokenized_content": [2, 4244, 6156, 18253, 3, 67, 5624, 1956, 2398, 24098, 8166, 12, 1925, 8151, 1927, 25, 17, 5334, 10547, 4086, 13, 2014, 4244, 6156, 18253, 12, 1925, 7829, 1927, 25, 17, 3]}, "items": [{"id": "p_603", "content": "3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 12, 21, 16, 22, 16, 25, 16, 26, 17, 21196, 18425, 1960, 17, 24, 17, 12111, 13, 23878, 1037, 12, 23, 16, 22, 17, 44, 13, 24828, 17, 25, 17, 2340, 3, 3]}]}
{"query": {"id": "q_604", "content": "hyperlocomotion [SEP] 562 (1 microg/side). Our findings indicate that cocaine induced hyperlocomotion is modified by 5-HT1B receptor ligands microinjected into the a", "tokenized_content": [2, 4194, 6012, 13055, 13323, 1916, 3, 4489, 1028, 12, 21, 12517, 19, 4159, 13, 18, 2342, 3056, 3579, 1988, 9045, 2719, 4194, 6012, 13055, 13323, 1916, 1977, 4795, 2007, 25, 3]}, "items": [{"id": "p_604", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_605", "content": "Ticlopidine [SEP] Ticlopidine-induced cholestatic hepatitis.", "tokenized_content": [2, 18298, 6012, 10984, 27099, 3, 18298, 6012, 10984, 27099, 17, 2719, 21211, 2479, 7977, 18, 3]}, "items": [{"id": "p_605", "content": "Ticlopidine [SEP] An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18298, 6012, 10984, 27099, 3, 1925, 3655, 4106, 1927, 7163, 7883, 5384, 2251, 1922, 1920, 9555, 1927, 18478, 1922, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_606", "content": "cholestatic [SEP] Ticlopidine-induced cholestatic hepatitis.", "tokenized_content": [2, 21211, 2479, 3, 18298, 6012, 10984, 27099, 17, 2719, 21211, 2479, 7977, 18, 3]}, "items": [{"id": "p_606", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_607", "content": "hepatitis [SEP] Ticlopidine-induced cholestatic hepatitis.", "tokenized_content": [2, 7977, 3, 18298, 6012, 10984, 27099, 17, 2719, 21211, 2479, 7977, 18, 3]}, "items": [{"id": "p_607", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_608", "content": "ticlopidine [SEP] OBJECTIVE: To report 2 cases of ticlopidine-induced cholestatic hepatitis, investigate its mechanism, and c", "tokenized_content": [2, 18298, 6012, 10984, 27099, 3, 4470, 30, 1942, 3809, 22, 2919, 1927, 18298, 6012, 10984, 27099, 17, 2719, 21211, 2479, 7977, 16, 4482, 2496, 2856, 16, 1930, 45, 3]}, "items": [{"id": "p_608", "content": "Ticlopidine [SEP] An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18298, 6012, 10984, 27099, 3, 1925, 3655, 4106, 1927, 7163, 7883, 5384, 2251, 1922, 1920, 9555, 1927, 18478, 1922, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_609", "content": "cholestatic [SEP] OBJECTIVE: To report 2 cases of ticlopidine-induced cholestatic hepatitis, investigate its mechanism, and compare the observed ", "tokenized_content": [2, 21211, 2479, 3, 4470, 30, 1942, 3809, 22, 2919, 1927, 18298, 6012, 10984, 27099, 17, 2719, 21211, 2479, 7977, 16, 4482, 2496, 2856, 16, 1930, 5175, 1920, 2528, 3]}, "items": [{"id": "p_609", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_610", "content": "hepatitis [SEP] OBJECTIVE: To report 2 cases of ticlopidine-induced cholestatic hepatitis, investigate its mechanism, and compare the observed main chara", "tokenized_content": [2, 7977, 3, 4470, 30, 1942, 3809, 22, 2919, 1927, 18298, 6012, 10984, 27099, 17, 2719, 21211, 2479, 7977, 16, 4482, 2496, 2856, 16, 1930, 5175, 1920, 2528, 2730, 2618, 1019, 3]}, "items": [{"id": "p_610", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_611", "content": "Cholestatic [SEP] vitro in the patients, but not in healthy controls. DISCUSSION: Cholestatic hepatitis is a rare complication of the antiplatelet agent ticl", "tokenized_content": [2, 21211, 2479, 3, 3596, 1922, 1920, 2132, 16, 2308, 2084, 1922, 4097, 3562, 18, 7248, 30, 21211, 2479, 7977, 1977, 43, 5844, 9388, 1927, 1920, 21348, 5899, 18298, 1024, 3]}, "items": [{"id": "p_611", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_612", "content": "jaundice [SEP] orted but few in the English literature. Our patients developed jaundice following treatment with ticlopidine and showed the clinical an", "tokenized_content": [2, 25314, 3, 2014, 2013, 2308, 3855, 1922, 1920, 8998, 4431, 18, 2342, 2132, 3530, 25314, 2894, 2311, 1956, 18298, 6012, 10984, 27099, 1930, 2594, 1920, 2535, 1925, 3]}, "items": [{"id": "p_612", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_613", "content": "Hepatitis [SEP] ic hepatitis, which resolved after discontinuation of the drug. Hepatitis may develop weeks after discontinuation of the drug and may run", "tokenized_content": [2, 7977, 3, 3996, 7977, 16, 2154, 8397, 2256, 14775, 1927, 1920, 2838, 18, 7977, 2278, 2392, 3625, 2256, 14775, 1927, 1920, 2838, 1930, 2278, 4747, 3]}, "items": [{"id": "p_613", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_614", "content": "cholestasis [SEP]  use of ticlopidine. The mechanisms of this ticlopidine-induced cholestasis are unclear. Immune mechanisms may be involved in the drug's he", "tokenized_content": [2, 30086, 3, 2485, 1927, 18298, 6012, 10984, 27099, 18, 1920, 3531, 1927, 2052, 18298, 6012, 10984, 27099, 17, 2719, 30086, 2032, 6390, 18, 3743, 3531, 2278, 1998, 3286, 1922, 1920, 3]}, "items": [{"id": "p_614", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_615", "content": "hepatotoxicity [SEP] is are unclear. Immune mechanisms may be involved in the drug's hepatotoxicity, as suggested by the T-cell stimulation study reported here. CO", "tokenized_content": [2, 24126, 3, 1977, 2032, 6390, 18, 3743, 3531, 2278, 1998, 3286, 1922, 1920, 2838, 11, 61, 24126, 16, 1966, 3978, 2007, 1920, 62, 17, 2024, 4177, 2161, 2568, 3410, 18, 3]}, "items": [{"id": "p_615", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_616", "content": "clopidogrel [SEP] s ticlopidine is being replaced by the newer antiplatelet agent clopidogrel.", "tokenized_content": [2, 20473, 3, 61, 18298, 6012, 10984, 27099, 1977, 3301, 8403, 2007, 1920, 18012, 21348, 5899, 20473, 18, 3]}, "items": [{"id": "p_616", "content": "clopidogrel [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 20473, 3, 3]}]}
{"query": {"id": "q_617", "content": "sodium [SEP] Epithelial sodium channel (ENaC) subunit mRNA and protein expression in rats with", "tokenized_content": [2, 5227, 3, 4944, 5227, 4999, 12, 24971, 13, 5903, 3616, 1930, 2213, 2294, 1922, 3615, 1956, 3]}, "items": [{"id": "p_617", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_618", "content": "puromycin aminonucleoside [SEP] channel (ENaC) subunit mRNA and protein expression in rats with puromycin aminonucleoside-induced nephrotic syndrome.", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 4999, 12, 24971, 13, 5903, 3616, 1930, 2213, 2294, 1922, 3615, 1956, 19750, 3835, 1022, 2626, 8028, 17, 2719, 29646, 4741, 18, 3]}, "items": [{"id": "p_618", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_619", "content": "nephrotic syndrome [SEP] otein expression in rats with puromycin aminonucleoside-induced nephrotic syndrome.", "tokenized_content": [2, 29646, 4741, 3, 7608, 14818, 2294, 1922, 3615, 1956, 19750, 3835, 1022, 2626, 8028, 17, 2719, 29646, 4741, 18, 3]}, "items": [{"id": "p_619", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_620", "content": "nephrotic syndrome [SEP] In experimental nephrotic syndrome, urinary sodium excretion is decreased during the early phase o", "tokenized_content": [2, 29646, 4741, 3, 1922, 3599, 29646, 4741, 16, 7075, 5227, 11093, 1977, 3261, 2409, 1920, 3120, 3193, 57, 3]}, "items": [{"id": "p_620", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_621", "content": "sodium [SEP] In experimental nephrotic syndrome, urinary sodium excretion is decreased during the early phase of the disease. T", "tokenized_content": [2, 5227, 3, 1922, 3599, 29646, 4741, 16, 7075, 5227, 11093, 1977, 3261, 2409, 1920, 3120, 3193, 1927, 1920, 2573, 18, 62, 3]}, "items": [{"id": "p_621", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_622", "content": "puromycin aminonucleoside [SEP] We examined the abundance of ENaC subunit mRNAs and proteins in puromycin aminonucleoside (PAN)-induced nephrotic syndrome. The time courses of urinary s", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 2038, 3572, 1920, 6232, 1927, 24971, 5903, 8806, 1930, 2697, 1922, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 17, 2719, 29646, 4741, 18, 3]}, "items": [{"id": "p_622", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_623", "content": "PAN [SEP] f ENaC subunit mRNAs and proteins in puromycin aminonucleoside (PAN)-induced nephrotic syndrome. The time courses of urinary sodium", "tokenized_content": [2, 3797, 3, 48, 24971, 5903, 8806, 1930, 2697, 1922, 19750, 3835, 1022, 2626, 8028, 12, 3797, 13, 17, 2719, 29646, 4741, 18, 1920, 2367, 12726, 1927, 7075, 5227, 3]}, "items": [{"id": "p_623", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_624", "content": "aldosterone [SEP]  syndrome. The time courses of urinary sodium excretion, plasma aldosterone concentration and proteinuria were studied in male Sprague-Dawl", "tokenized_content": [2, 16944, 3, 4741, 18, 1920, 2367, 12726, 1927, 7075, 5227, 11093, 16, 3582, 16944, 3110, 1930, 15831, 1985, 3942, 1922, 4005, 15684, 17, 13368, 1024, 3]}, "items": [{"id": "p_624", "content": "Aldosterone [SEP] A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodiu", "score": 1, "type": null, "tokenized_content": [2, 16944, 3, 43, 6365, 8366, 2007, 1920, 10651, 4997, 1988, 7014, 15428, 1930, 3224, 6766, 2007, 3605, 1920, 4604, 7521, 1927, 4546, 1033, 1032, 3]}]}
{"query": {"id": "q_625", "content": "proteinuria [SEP]  urinary sodium excretion, plasma aldosterone concentration and proteinuria were studied in male Sprague-Dawley rats treated with a single ", "tokenized_content": [2, 15831, 3, 7075, 5227, 11093, 16, 3582, 16944, 3110, 1930, 15831, 1985, 3942, 1922, 4005, 15684, 17, 15798, 3615, 2868, 1956, 43, 2957, 3]}, "items": [{"id": "p_625", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_626", "content": "Sodium [SEP]  of proteinuria were comparable with those reported previously. Sodium retention occurred on days 2, 3 and 6 after PAN injection. A si", "tokenized_content": [2, 5227, 3, 1927, 15831, 1985, 5596, 1956, 2690, 2568, 3024, 18, 5227, 7521, 4807, 1990, 3000, 22, 16, 23, 1930, 26, 2256, 3797, 4107, 18, 43, 5998, 3]}, "items": [{"id": "p_626", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_627", "content": "NO [SEP] NO-induced migraine attack: strong increase in plasma calcitonin g", "tokenized_content": [2, 2239, 3, 2239, 17, 2719, 13258, 8926, 30, 3206, 2760, 1922, 3582, 26406, 49, 3]}, "items": [{"id": "p_627", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_628", "content": "migraine [SEP] NO-induced migraine attack: strong increase in plasma calcitonin gene-related pepti", "tokenized_content": [2, 13258, 3, 2239, 17, 2719, 13258, 8926, 30, 3206, 2760, 1922, 3582, 26406, 2359, 17, 2712, 23045, 1033, 3]}, "items": [{"id": "p_628", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_629", "content": "calcitonin gene-related peptide [SEP] NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet ser", "tokenized_content": [2, 26406, 2359, 17, 2712, 4207, 3, 2239, 17, 2719, 13258, 8926, 30, 3206, 2760, 1922, 3582, 26406, 2359, 17, 2712, 4207, 12, 20468, 13, 3110, 1930, 3136, 3670, 1956, 7163, 3]}, "items": [{"id": "p_629", "content": "Calcitonin Gene-Related Peptide [SEP] Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative ", "score": 1, "type": null, "tokenized_content": [2, 26406, 2359, 17, 2712, 4207, 3, 26406, 2359, 17, 2712, 4207, 18, 43, 3191, 17, 3835, 2687, 4207, 3595, 2037, 1920, 26406, 2359, 18, 2176, 5110, 1966, 43, 3211, 1927, 5012, 3]}]}
{"query": {"id": "q_630", "content": "CGRP [SEP] ack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin", "tokenized_content": [2, 20468, 3, 2000, 1040, 30, 3206, 2760, 1922, 3582, 26406, 2359, 17, 2712, 4207, 12, 20468, 13, 3110, 1930, 3136, 3670, 1956, 7163, 11153, 3]}, "items": [{"id": "p_630", "content": "Calcitonin Gene-Related Peptide [SEP] Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative ", "score": 1, "type": null, "tokenized_content": [2, 26406, 2359, 17, 2712, 4207, 3, 26406, 2359, 17, 2712, 4207, 18, 43, 3191, 17, 3835, 2687, 4207, 3595, 2037, 1920, 26406, 2359, 18, 2176, 5110, 1966, 43, 3211, 1927, 5012, 3]}]}
{"query": {"id": "q_631", "content": "serotonin [SEP] ide (CGRP) concentration and negative correlation with platelet serotonin release.", "tokenized_content": [2, 11153, 3, 9043, 12, 20468, 13, 3110, 1930, 3136, 3670, 1956, 7163, 11153, 4012, 18, 3]}, "items": [{"id": "p_631", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_632", "content": "calcitonin gene-related peptide [SEP] m of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamin", "tokenized_content": [2, 26406, 2359, 17, 2712, 4207, 3, 55, 1927, 1920, 2481, 2161, 1982, 1942, 4482, 2840, 1922, 1920, 3582, 26406, 2359, 17, 2712, 4207, 12, 20468, 13, 3110, 1930, 7163, 11153, 3]}, "items": [{"id": "p_632", "content": "Calcitonin Gene-Related Peptide [SEP] Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative ", "score": 1, "type": null, "tokenized_content": [2, 26406, 2359, 17, 2712, 4207, 3, 26406, 2359, 17, 2712, 4207, 18, 43, 3191, 17, 3835, 2687, 4207, 3595, 2037, 1920, 26406, 2359, 18, 2176, 5110, 1966, 43, 3211, 1927, 5012, 3]}]}
{"query": {"id": "q_633", "content": "CGRP [SEP] estigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-H", "tokenized_content": [2, 20468, 3, 3255, 1950, 2010, 2840, 1922, 1920, 3582, 26406, 2359, 17, 2712, 4207, 12, 20468, 13, 3110, 1930, 7163, 11153, 12, 25, 17, 8275, 1997, 14302, 3812, 16, 25, 3]}, "items": [{"id": "p_633", "content": "Calcitonin Gene-Related Peptide [SEP] Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative ", "score": 1, "type": null, "tokenized_content": [2, 26406, 2359, 17, 2712, 4207, 3, 26406, 2359, 17, 2712, 4207, 18, 43, 3191, 17, 3835, 2687, 4207, 3595, 2037, 1920, 26406, 2359, 18, 2176, 5110, 1966, 43, 3211, 1927, 5012, 3]}]}
{"query": {"id": "q_634", "content": "serotonin [SEP] lcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headac", "tokenized_content": [2, 11153, 3, 5236, 8439, 1921, 2359, 17, 2712, 4207, 12, 20468, 13, 3110, 1930, 7163, 11153, 12, 25, 17, 8275, 1997, 14302, 3812, 16, 25, 17, 5334, 13, 3919, 2409, 3]}, "items": [{"id": "p_634", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_635", "content": "5-hydroxytriptamine [SEP] ne-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed ge", "tokenized_content": [2, 25, 17, 8275, 1997, 14302, 3812, 3, 2069, 17, 2712, 4207, 12, 20468, 13, 3110, 1930, 7163, 11153, 12, 25, 17, 8275, 1997, 14302, 3812, 16, 25, 17, 5334, 13, 3]}, "items": [{"id": "p_635", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_636", "content": "5-HT [SEP] GRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine ", "tokenized_content": [2, 25, 17, 5334, 3, 16945, 13, 3110, 1930, 7163, 11153, 12, 25, 17, 8275, 1997, 14302, 3812, 16, 25, 17, 5334, 13, 3919, 2409, 1920, 8426, 12187, 1930, 1920, 7083, 3]}, "items": [{"id": "p_636", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_637", "content": "headache [SEP] otonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycer", "tokenized_content": [2, 12187, 3, 7608, 6655, 12, 25, 17, 8275, 1997, 14302, 3812, 16, 25, 17, 5334, 13, 3919, 2409, 1920, 8426, 12187, 1930, 1920, 7083, 26336, 13258, 8926, 27116, 2007, 8686, 3]}, "items": [{"id": "p_637", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_638", "content": "migraine [SEP] ) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (w", "tokenized_content": [2, 13258, 3, 13, 3919, 2409, 1920, 8426, 12187, 1930, 1920, 7083, 26336, 13258, 8926, 27116, 2007, 8686, 14966, 1921, 18, 16173, 4232, 13258, 2920, 12, 65, 3]}, "items": [{"id": "p_638", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_639", "content": "nitroglycerin [SEP] te headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura) and eight controls p", "tokenized_content": [2, 8686, 14966, 1921, 3, 3602, 12187, 1930, 1920, 7083, 26336, 13258, 8926, 27116, 2007, 8686, 14966, 1921, 18, 16173, 4232, 13258, 2920, 12, 2979, 11826, 1019, 13, 1930, 5066, 3562, 3]}, "items": [{"id": "p_639", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_640", "content": "migraineurs (without aura) [SEP] nuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura) and eight controls participated in the study. Sublingual nitrog", "tokenized_content": [2, 13258, 2920, 12, 2979, 11826, 1019, 13, 3, 13232, 2053, 13258, 8926, 27116, 2007, 8686, 14966, 1921, 18, 16173, 4232, 13258, 2920, 12, 2979, 11826, 1019, 13, 1930, 5066, 3562, 3]}, "items": [{"id": "p_640", "content": "Migraine without Aura [SEP] Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is character", "score": 1, "type": null, "tokenized_content": [2, 13258, 2979, 11826, 1019, 3, 7457, 12059, 25960, 24339, 16, 2084, 16757, 2014, 7936, 2007, 1925, 11826, 1019, 16, 1922, 15413, 11671, 24, 17, 4395, 3967, 18, 2176, 1977, 2728, 3]}]}
{"query": {"id": "q_641", "content": "Coronary aneurysm [SEP] Coronary aneurysm after implantation of a paclitaxel-eluting stent.", "tokenized_content": [2, 5846, 13373, 3, 5846, 13373, 2256, 8958, 1927, 43, 12404, 17, 22295, 10772, 18, 3]}, "items": [{"id": "p_641", "content": "Coronary Aneurysm [SEP] Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLE", "score": 1, "type": null, "tokenized_content": [2, 5846, 13373, 3, 4552, 13819, 17, 2014, 10791, 17, 3189, 17799, 1922, 1920, 4821, 1927, 5846, 7208, 18, 2501, 5846, 16673, 2032, 2810, 1942, 5846, 7274, 21624, 1952, 3]}]}
{"query": {"id": "q_642", "content": "paclitaxel [SEP] Coronary aneurysm after implantation of a paclitaxel-eluting stent.", "tokenized_content": [2, 12404, 3, 5846, 13373, 2256, 8958, 1927, 43, 12404, 17, 22295, 10772, 18, 3]}, "items": [{"id": "p_642", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_643", "content": "coronary aneurysm [SEP] Formation of coronary aneurysm is a rare complication of stenting with bare metal stents, but ", "tokenized_content": [2, 5846, 13373, 3, 3337, 1927, 5846, 13373, 1977, 43, 5844, 9388, 1927, 22630, 1956, 18689, 6048, 18478, 16, 2308, 3]}, "items": [{"id": "p_643", "content": "Coronary Aneurysm [SEP] Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLE", "score": 1, "type": null, "tokenized_content": [2, 5846, 13373, 3, 4552, 13819, 17, 2014, 10791, 17, 3189, 17799, 1922, 1920, 4821, 1927, 5846, 7208, 18, 2501, 5846, 16673, 2032, 2810, 1942, 5846, 7274, 21624, 1952, 3]}]}
{"query": {"id": "q_644", "content": "aneurysm [SEP] Formation of coronary aneurysm is a rare complication of stenting with bare metal stents, but ", "tokenized_content": [2, 13373, 3, 3337, 1927, 5846, 13373, 1977, 43, 5844, 9388, 1927, 22630, 1956, 18689, 6048, 18478, 16, 2308, 3]}, "items": [{"id": "p_644", "content": "Aneurysm [SEP] Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM", "score": 1, "type": null, "tokenized_content": [2, 13373, 3, 6598, 2397, 7056, 16908, 2029, 2014, 10791, 17, 3189, 17799, 1922, 1920, 4821, 1927, 2967, 2877, 8072, 12, 9345, 2014, 14785, 13, 2014, 1920, 4003, 12, 4003, 13373, 3]}]}
{"query": {"id": "q_645", "content": "thrombosis [SEP]  apposition, aneurysm formation and with the potential of stent thrombosis or vessel rupture. We present a 43-year-old man who developed a", "tokenized_content": [2, 11354, 3, 2847, 23050, 16, 13373, 3337, 1930, 1956, 1920, 2889, 1927, 10772, 11354, 2014, 8072, 12460, 18, 2038, 2481, 43, 3941, 17, 2476, 17, 4156, 2323, 2746, 3530, 43, 3]}, "items": [{"id": "p_645", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_646", "content": "paclitaxel [SEP] neurysm in the right coronary artery 6 months after receiving a paclitaxel-eluting stent. The patient was asymptomatic and the aneurysm wa", "tokenized_content": [2, 12404, 3, 2974, 28931, 1922, 1920, 3659, 5846, 5511, 26, 3221, 2256, 5962, 43, 12404, 17, 22295, 10772, 18, 1920, 2774, 1982, 9978, 1930, 1920, 13373, 4114, 3]}, "items": [{"id": "p_646", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_647", "content": "urotensin-II [SEP] Behavioral effects of urotensin-II centrally administered in mice.", "tokenized_content": [2, 14984, 2777, 6777, 17, 2890, 3, 5343, 2564, 1927, 14984, 2777, 6777, 17, 2890, 20424, 5254, 1922, 2518, 18, 3]}, "items": [{"id": "p_647", "content": "Urotensins [SEP] Teleost hormones. A family of small peptides isolated from urophyses of bony fishes. They have many different physiological effe", "score": 1, "type": null, "tokenized_content": [2, 14984, 2777, 6777, 1036, 3, 10304, 2259, 10224, 18, 43, 3416, 1927, 2858, 5320, 3937, 2037, 14984, 25818, 4127, 1036, 1927, 18525, 23040, 18, 2611, 2162, 3086, 2413, 5005, 2121, 1021, 3]}]}
{"query": {"id": "q_648", "content": "Urotensin-II [SEP] Urotensin-II (U-II) receptors are widely distributed in the central nervous ", "tokenized_content": [2, 14984, 2777, 6777, 17, 2890, 3, 14984, 2777, 6777, 17, 2890, 12, 63, 17, 2890, 13, 4086, 2032, 5673, 6533, 1922, 1920, 4101, 7580, 3]}, "items": [{"id": "p_648", "content": "Urotensins [SEP] Teleost hormones. A family of small peptides isolated from urophyses of bony fishes. They have many different physiological effe", "score": 1, "type": null, "tokenized_content": [2, 14984, 2777, 6777, 1036, 3, 10304, 2259, 10224, 18, 43, 3416, 1927, 2858, 5320, 3937, 2037, 14984, 25818, 4127, 1036, 1927, 18525, 23040, 18, 2611, 2162, 3086, 2413, 5005, 2121, 1021, 3]}]}
{"query": {"id": "q_649", "content": "U-II [SEP] Urotensin-II (U-II) receptors are widely distributed in the central nervous system", "tokenized_content": [2, 63, 17, 2890, 3, 14984, 2777, 6777, 17, 2890, 12, 63, 17, 2890, 13, 4086, 2032, 5673, 6533, 1922, 1920, 4101, 7580, 2433, 3]}, "items": [{"id": "p_649", "content": "Urotensins [SEP] Teleost hormones. A family of small peptides isolated from urophyses of bony fishes. They have many different physiological effe", "score": 1, "type": null, "tokenized_content": [2, 14984, 2777, 6777, 1036, 3, 10304, 2259, 10224, 18, 43, 3416, 1927, 2858, 5320, 3937, 2037, 14984, 25818, 4127, 1036, 1927, 18525, 23040, 18, 2611, 2162, 3086, 2413, 5005, 2121, 1021, 3]}]}
{"query": {"id": "q_650", "content": "hypertension [SEP] stem. Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secret", "tokenized_content": [2, 5579, 3, 4402, 18, 19343, 18474, 24722, 12, 51, 18, 45, 18, 64, 18, 13, 4107, 1927, 63, 17, 2890, 5092, 5579, 1930, 26192, 1930, 11803, 18386, 1930, 30482, 22628, 3]}, "items": [{"id": "p_650", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_651", "content": "bradycardia [SEP] oventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. However, th", "tokenized_content": [2, 26192, 3, 20708, 3319, 2168, 12, 51, 18, 45, 18, 64, 18, 13, 4107, 1927, 63, 17, 2890, 5092, 5579, 1930, 26192, 1930, 11803, 18386, 1930, 30482, 22628, 5512, 18, 3]}, "items": [{"id": "p_651", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_652", "content": "apomorphine [SEP] tration of U-II had no effect on body temperature, nociception, apomorphine-induced penile erection and climbing behavior, and stress-induc", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 3390, 1929, 1927, 63, 17, 2890, 2430, 2239, 2495, 1990, 3362, 3449, 16, 14551, 15577, 16, 11466, 12492, 11119, 7969, 2912, 17, 2719, 22609, 3]}, "items": [{"id": "p_652", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_653", "content": "penile erection [SEP] no effect on body temperature, nociception, apomorphine-induced penile erection and climbing behavior, and stress-induced plasma corticosterone", "tokenized_content": [2, 22609, 24311, 1929, 3, 2239, 2495, 1990, 3362, 3449, 16, 14551, 15577, 16, 11466, 12492, 11119, 7969, 2912, 17, 2719, 22609, 24311, 1929, 1930, 25449, 3379, 16, 1930, 3071, 17, 3]}, "items": [{"id": "p_653", "content": "Penile Diseases [SEP] Pathological processes involving the PENIS or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22609, 3902, 3, 6598, 4028, 5884, 1920, 29918, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_654", "content": "corticosterone [SEP] enile erection and climbing behavior, and stress-induced plasma corticosterone level. Taken together, the present study demonstrates that the ", "tokenized_content": [2, 18136, 3, 2066, 2383, 24311, 1929, 1930, 25449, 3379, 16, 1930, 3071, 17, 2719, 3582, 18136, 2237, 18, 4208, 4084, 16, 1920, 2481, 2161, 7706, 1988, 1920, 3]}, "items": [{"id": "p_654", "content": "Corticosterone [SEP] An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman ", "score": 1, "type": null, "tokenized_content": [2, 18136, 3, 1925, 7206, 16557, 9507, 1988, 2258, 9194, 2308, 2228, 4209, 1966, 43, 8463, 10323, 2642, 1930, 43, 14469, 18, 12, 2037, 4227, 3862, 3]}]}
{"query": {"id": "q_655", "content": "psychiatric disorders [SEP] These data suggest that U-II may be involved in some aspects of psychiatric disorders.", "tokenized_content": [2, 7652, 4414, 3, 2144, 2230, 3220, 1988, 63, 17, 2890, 2278, 1998, 3286, 1922, 2673, 6082, 1927, 7652, 4414, 18, 3]}, "items": [{"id": "p_655", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_656", "content": "dysphonia [SEP] Recurrent dysphonia and acitretin.", "tokenized_content": [2, 17156, 6114, 3, 7457, 17156, 6114, 1930, 2000, 18281, 2268, 18, 3]}, "items": [{"id": "p_656", "content": "Dysphonia [SEP] Difficulty and/or pain in PHONATION or speaking.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17156, 6114, 3, 8791, 1930, 19, 2014, 3594, 1922, 11999, 1943, 2014, 15073, 18, 3]}]}
{"query": {"id": "q_657", "content": "acitretin [SEP] Recurrent dysphonia and acitretin.", "tokenized_content": [2, 2000, 18281, 2268, 3, 7457, 17156, 6114, 1930, 2000, 18281, 2268, 18, 3]}, "items": [{"id": "p_657", "content": "Acitretin [SEP] An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much ", "score": 1, "type": null, "tokenized_content": [2, 2000, 18281, 2268, 3, 1925, 4726, 26885, 3655, 1922, 1920, 2311, 1927, 14109, 18, 2176, 1977, 1920, 3044, 9483, 1927, 2140, 26313, 2010, 1956, 1920, 6607, 1927, 43, 4186, 3]}]}
{"query": {"id": "q_658", "content": "dysphonia [SEP] We report the case of a woman complaining of dysphonia while she was treated by acitretin. Her symptoms totally regres", "tokenized_content": [2, 17156, 6114, 3, 2038, 3809, 1920, 3087, 1927, 43, 10440, 6581, 2465, 1927, 17156, 6114, 2679, 4693, 1982, 2868, 2007, 2000, 18281, 2268, 18, 3656, 3601, 15616, 3995, 1918, 3]}, "items": [{"id": "p_658", "content": "Dysphonia [SEP] Difficulty and/or pain in PHONATION or speaking.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17156, 6114, 3, 8791, 1930, 19, 2014, 3594, 1922, 11999, 1943, 2014, 15073, 18, 3]}]}
{"query": {"id": "q_659", "content": "acitretin [SEP] se of a woman complaining of dysphonia while she was treated by acitretin. Her symptoms totally regressed after drug withdrawal and reapp", "tokenized_content": [2, 2000, 18281, 2268, 3, 2058, 1927, 43, 10440, 6581, 2465, 1927, 17156, 6114, 2679, 4693, 1982, 2868, 2007, 2000, 18281, 2268, 18, 3656, 3601, 15616, 26832, 2256, 2838, 9594, 1930, 3]}, "items": [{"id": "p_659", "content": "Acitretin [SEP] An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much ", "score": 1, "type": null, "tokenized_content": [2, 2000, 18281, 2268, 3, 1925, 4726, 26885, 3655, 1922, 1920, 2311, 1927, 14109, 18, 2176, 1977, 1920, 3044, 9483, 1927, 2140, 26313, 2010, 1956, 1920, 6607, 1927, 43, 4186, 3]}]}
{"query": {"id": "q_660", "content": "pain [SEP] Pharmacological modulation of pain-related brain activity during normal and central sensitization ", "tokenized_content": [2, 3594, 3, 7683, 7145, 1927, 3594, 17, 2712, 3068, 2455, 2409, 2791, 1930, 4101, 12770, 3]}, "items": [{"id": "p_660", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_661", "content": "pain [SEP] ral sensitization) is the mechanism accounting for the enhanced pain sensitivity in the skin surrounding tissue injury (secondary hy", "tokenized_content": [2, 3594, 3, 15906, 12770, 13, 1977, 1920, 2856, 10919, 1958, 1920, 4256, 3594, 3802, 1922, 1920, 4407, 7510, 2960, 4047, 12, 4067, 4527, 3]}, "items": [{"id": "p_661", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_662", "content": "tissue injury [SEP] nting for the enhanced pain sensitivity in the skin surrounding tissue injury (secondary hyperalgesia). Secondary hyperalgesia shares clinica", "tokenized_content": [2, 2960, 4047, 3, 5891, 1941, 1958, 1920, 4256, 3594, 3802, 1922, 1920, 4407, 7510, 2960, 4047, 12, 4067, 21525, 13, 18, 4067, 21525, 16495, 6248, 1019, 3]}, "items": [{"id": "p_662", "content": "Soft Tissue Injuries [SEP] Injuries of tissue other than bone. The concept is usually general and does not customarily refer to internal organs or viscera.", "score": 1, "type": null, "tokenized_content": [2, 3793, 2960, 8209, 3, 8209, 1927, 2960, 2303, 2254, 3622, 18, 1920, 5658, 1977, 5394, 3335, 1930, 3731, 2084, 10206, 4697, 3333, 1942, 4495, 7393, 2014, 12108, 1019, 18, 3]}]}
{"query": {"id": "q_663", "content": "secondary hyperalgesia [SEP] nhanced pain sensitivity in the skin surrounding tissue injury (secondary hyperalgesia). Secondary hyperalgesia shares clinical characteristics with n", "tokenized_content": [2, 4067, 21525, 3, 5331, 3419, 3594, 3802, 1922, 1920, 4407, 7510, 2960, 4047, 12, 4067, 21525, 13, 18, 4067, 21525, 16495, 2535, 3779, 1956, 56, 3]}, "items": [{"id": "p_663", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_664", "content": "Secondary hyperalgesia [SEP] in the skin surrounding tissue injury (secondary hyperalgesia). Secondary hyperalgesia shares clinical characteristics with neurogenic hyperalgesia in", "tokenized_content": [2, 4067, 21525, 3, 1922, 1920, 4407, 7510, 2960, 4047, 12, 4067, 21525, 13, 18, 4067, 21525, 16495, 2535, 3779, 1956, 21113, 21525, 1922, 3]}, "items": [{"id": "p_664", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_665", "content": "neurogenic hyperalgesia [SEP] a). Secondary hyperalgesia shares clinical characteristics with neurogenic hyperalgesia in patients with neuropathic pain. Abnormal brain responses to ", "tokenized_content": [2, 21113, 21525, 3, 43, 13, 18, 4067, 21525, 16495, 2535, 3779, 1956, 21113, 21525, 1922, 2132, 1956, 16591, 3594, 18, 4552, 3068, 3387, 1942, 3]}, "items": [{"id": "p_665", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_666", "content": "neuropathic pain [SEP] l characteristics with neurogenic hyperalgesia in patients with neuropathic pain. Abnormal brain responses to somatosensory stimuli have been fo", "tokenized_content": [2, 16591, 3594, 3, 54, 3779, 1956, 21113, 21525, 1922, 2132, 1956, 16591, 3594, 18, 4552, 3068, 3387, 1942, 17562, 5458, 2162, 2252, 5917, 3]}, "items": [{"id": "p_666", "content": "Neuralgia [SEP] Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5181, 11966, 3, 10702, 2014, 3546, 1941, 3594, 1988, 5110, 4231, 1920, 4914, 2014, 3282, 1927, 43, 5009, 2014, 13598, 5507, 18, 3]}]}
{"query": {"id": "q_667", "content": "hyperalgesia [SEP] in sensitivity in the skin surrounding tissue injury (secondary hyperalgesia). Secondary hyperalgesia shares clinical characteristics with n", "tokenized_content": [2, 21525, 3, 1922, 3802, 1922, 1920, 4407, 7510, 2960, 4047, 12, 4067, 21525, 13, 18, 4067, 21525, 16495, 2535, 3779, 1956, 56, 3]}, "items": [{"id": "p_667", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_668", "content": "gabapentin [SEP] nsitization. The aim of this study was to assess the effects of gabapentin, a drug effective in neuropathic pain patients, on brain proces", "tokenized_content": [2, 30303, 3, 4246, 2078, 7659, 18, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 2634, 1920, 2564, 1927, 30303, 16, 43, 2838, 3655, 1922, 16591, 3594, 2132, 16, 1990, 3068, 9803, 3]}, "items": [{"id": "p_668", "content": "gabapentin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 30303, 3, 3]}]}
{"query": {"id": "q_669", "content": "capsaicin [SEP] sponse to nociceptive mechanical stimulation of normal skin and capsaicin-induced secondary hyperalgesia. The dose of gabapentin was 1,80", "tokenized_content": [2, 19156, 3, 15312, 1021, 1942, 19034, 5821, 4177, 1927, 2791, 4407, 1930, 19156, 17, 2719, 4067, 21525, 18, 1920, 3253, 1927, 30303, 1982, 21, 16, 3729, 3]}, "items": [{"id": "p_669", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_670", "content": "MDMA [SEP] MDMA polydrug users show process-specific central executive impairme", "tokenized_content": [2, 27933, 3, 27933, 19534, 14411, 6603, 2146, 2585, 17, 2487, 4101, 11627, 3960, 3870, 3]}, "items": [{"id": "p_670", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_671", "content": "impaired social and emotional judgement processes [SEP] how process-specific central executive impairments coupled with impaired social and emotional judgement processes.", "tokenized_content": [2, 5761, 3686, 1930, 6687, 24083, 2017, 4028, 3, 2307, 2585, 17, 2487, 4101, 11627, 12454, 6416, 1956, 5761, 3686, 1930, 6687, 24083, 2017, 4028, 18, 3]}, "items": [{"id": "p_671", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_672", "content": "memory deficits [SEP] In recent years working memory deficits have been reported in users of MDMA (3,4-methylenedioxymethamph", "tokenized_content": [2, 4525, 7961, 3, 1922, 3505, 2739, 5905, 4525, 7961, 2162, 2252, 2568, 1922, 6603, 1927, 27933, 12, 23, 16, 24, 17, 17947, 7408, 7221, 23568, 13430, 3]}, "items": [{"id": "p_672", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_673", "content": "MDMA [SEP] nt years working memory deficits have been reported in users of MDMA (3,4-methylenedioxymethamphetamine, ecstasy). The current study", "tokenized_content": [2, 27933, 3, 5891, 2739, 5905, 4525, 7961, 2162, 2252, 2568, 1922, 6603, 1927, 27933, 12, 23, 16, 24, 17, 17947, 7408, 7221, 23568, 18996, 16, 12587, 3857, 18801, 13, 18, 3]}, "items": [{"id": "p_673", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_674", "content": "3,4-methylenedioxymethamphetamine [SEP] rs working memory deficits have been reported in users of MDMA (3,4-methylenedioxymethamphetamine, ecstasy). The current study aimed to assess the impact of MDMA", "tokenized_content": [2, 23, 16, 24, 17, 17947, 7408, 7221, 23568, 18996, 3, 4366, 5905, 4525, 7961, 2162, 2252, 2568, 1922, 6603, 1927, 27933, 12, 23, 16, 24, 17, 17947, 7408, 7221, 23568, 3]}, "items": [{"id": "p_674", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_675", "content": "ecstasy [SEP] n reported in users of MDMA (3,4-methylenedioxymethamphetamine, ecstasy). The current study aimed to assess the impact of MDMA use on t", "tokenized_content": [2, 12587, 3857, 18801, 3, 56, 2568, 1922, 6603, 1927, 27933, 12, 23, 16, 24, 17, 17947, 7408, 7221, 23568, 18996, 16, 12587, 3857, 18801, 13, 18, 1920, 3214, 2161, 6822, 3]}, "items": [{"id": "p_675", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_676", "content": "citrate [SEP] Severe citrate toxicity complicating volunteer apheresis platelet donation.", "tokenized_content": [2, 11599, 3, 4010, 11599, 5532, 6581, 6102, 2104, 19921, 12274, 10008, 1937, 7163, 17886, 18, 3]}, "items": [{"id": "p_676", "content": "sodium citrate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5227, 11599, 3, 3]}]}
{"query": {"id": "q_677", "content": "toxicity [SEP] Severe citrate toxicity complicating volunteer apheresis platelet donation.", "tokenized_content": [2, 5532, 3, 4010, 11599, 5532, 6581, 6102, 2104, 19921, 12274, 10008, 1937, 7163, 17886, 18, 3]}, "items": [{"id": "p_677", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_678", "content": "citrate [SEP] We report a case of severe citrate toxicity during volunteer donor apheresis platelet collection. ", "tokenized_content": [2, 11599, 3, 2038, 3809, 43, 3087, 1927, 4010, 11599, 5532, 2409, 19921, 6282, 12274, 10008, 1937, 7163, 4957, 18, 3]}, "items": [{"id": "p_678", "content": "sodium citrate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5227, 11599, 3, 3]}]}
{"query": {"id": "q_679", "content": "toxicity [SEP] We report a case of severe citrate toxicity during volunteer donor apheresis platelet collection. The donor", "tokenized_content": [2, 5532, 3, 2038, 3809, 43, 3087, 1927, 4010, 11599, 5532, 2409, 19921, 6282, 12274, 10008, 1937, 7163, 4957, 18, 1920, 6282, 3]}, "items": [{"id": "p_679", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_680", "content": "hypertension [SEP] heresis platelet donor. Past medical history was remarkable for hypertension, hyperlipidemia, and depression. Reported medications included ", "tokenized_content": [2, 5579, 3, 3410, 8362, 7163, 6282, 18, 5375, 3423, 4403, 1982, 11293, 1958, 5579, 16, 21381, 16, 1930, 4621, 18, 2568, 7719, 3063, 3]}, "items": [{"id": "p_680", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_681", "content": "hyperlipidemia [SEP] et donor. Past medical history was remarkable for hypertension, hyperlipidemia, and depression. Reported medications included bumetanide, prav", "tokenized_content": [2, 21381, 3, 2140, 6282, 18, 5375, 3423, 4403, 1982, 11293, 1958, 5579, 16, 21381, 16, 1930, 4621, 18, 2568, 7719, 3063, 3168, 14578, 8150, 3695, 16, 21227, 1020, 3]}, "items": [{"id": "p_681", "content": "Hyperlipidemias [SEP] Conditions with excess LIPIDS in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21381, 1036, 3, 2961, 1956, 5799, 8238, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_682", "content": "depression [SEP] al history was remarkable for hypertension, hyperlipidemia, and depression. Reported medications included bumetanide, pravastatin, and par", "tokenized_content": [2, 4621, 3, 1969, 4403, 1982, 11293, 1958, 5579, 16, 21381, 16, 1930, 4621, 18, 2568, 7719, 3063, 3168, 14578, 8150, 3695, 16, 21227, 15337, 16, 1930, 2096, 3]}, "items": [{"id": "p_682", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_683", "content": "bumetanide [SEP] , hyperlipidemia, and depression. Reported medications included bumetanide, pravastatin, and paroxetine. Thirty minutes from the start of ", "tokenized_content": [2, 3168, 14578, 8150, 3695, 3, 16, 21381, 16, 1930, 4621, 18, 2568, 7719, 3063, 3168, 14578, 8150, 3695, 16, 21227, 15337, 16, 1930, 21412, 15387, 18, 9942, 4814, 2037, 1920, 3]}, "items": [{"id": "p_683", "content": "Bumetanide [SEP] A sulfamyl diuretic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3168, 14578, 8150, 3695, 3, 43, 5141, 27302, 26829, 18, 3]}]}
{"query": {"id": "q_684", "content": "pravastatin [SEP] emia, and depression. Reported medications included bumetanide, pravastatin, and paroxetine. Thirty minutes from the start of the procedure", "tokenized_content": [2, 21227, 15337, 3, 2391, 2126, 16, 1930, 4621, 18, 2568, 7719, 3063, 3168, 14578, 8150, 3695, 16, 21227, 15337, 16, 1930, 21412, 15387, 18, 9942, 4814, 2037, 1920, 6413, 1927, 3]}, "items": [{"id": "p_684", "content": "Pravastatin [SEP] An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA ", "score": 1, "type": null, "tokenized_content": [2, 21227, 15337, 3, 1925, 2246, 8257, 4197, 8697, 9483, 3937, 2037, 5054, 1927, 9812, 13047, 5728, 1997, 2688, 6102, 18, 2176, 8016, 1966, 43, 10362, 4106, 1927, 12058, 10027, 3]}]}
{"query": {"id": "q_685", "content": "paroxetine [SEP] ion. Reported medications included bumetanide, pravastatin, and paroxetine. Thirty minutes from the start of the procedure, the donor note", "tokenized_content": [2, 21412, 15387, 3, 4755, 18, 2568, 7719, 3063, 3168, 14578, 8150, 3695, 16, 21227, 15337, 16, 1930, 21412, 15387, 18, 9942, 4814, 2037, 1920, 6413, 1927, 1920, 4360, 16, 1920, 3]}, "items": [{"id": "p_685", "content": "Paroxetine [SEP] A serotonin uptake inhibitor that is effective in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21412, 15387, 3, 43, 11153, 5047, 4106, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_686", "content": "tetany [SEP] ry rapidly developed acute onset of severe facial and extremity tetany. Empirical treatment with intravenous calcium gluconate was ini", "tokenized_content": [2, 9717, 5323, 3, 18650, 6221, 3530, 3939, 4727, 1927, 4010, 9567, 1930, 14884, 9717, 5323, 18, 9203, 2311, 1956, 7307, 5016, 3351, 8870, 1982, 1922, 1033, 3]}, "items": [{"id": "p_686", "content": "Tetany [SEP] A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This cond", "score": 1, "type": null, "tokenized_content": [2, 9717, 5323, 3, 43, 4770, 4378, 2007, 3760, 21596, 1918, 16, 24422, 6588, 1036, 16, 1930, 16549, 4907, 3825, 1024, 24431, 16, 1930, 2469, 4010, 16, 20867, 26544, 1930, 10060, 18, 2052, 8646, 3]}]}
{"query": {"id": "q_687", "content": "calcium gluconate [SEP] cial and extremity tetany. Empirical treatment with intravenous calcium gluconate was initiated, and muscle contractions slowly subsided over app", "tokenized_content": [2, 5016, 3351, 8870, 3, 24748, 1024, 1930, 14884, 9717, 5323, 18, 9203, 2311, 1956, 7307, 5016, 3351, 8870, 1982, 7796, 16, 1930, 3760, 15465, 11240, 23981, 1919, 2338, 2847, 3]}, "items": [{"id": "p_687", "content": "Calcium Gluconate [SEP] The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemi", "score": 1, "type": null, "tokenized_content": [2, 5016, 3351, 8870, 3, 1920, 5016, 7012, 1927, 3351, 3490, 2687, 18, 1920, 3547, 2258, 43, 5386, 1927, 7947, 16, 2710, 2496, 2485, 1966, 43, 5016, 24549, 14682, 1922, 30201, 1972, 7395, 3]}]}
{"query": {"id": "q_688", "content": "muscle contractions [SEP] treatment with intravenous calcium gluconate was initiated, and muscle contractions slowly subsided over approximately 10 to 15 minutes. The events", "tokenized_content": [2, 3760, 15465, 3, 2311, 1956, 7307, 5016, 3351, 8870, 1982, 7796, 16, 1930, 3760, 15465, 11240, 23981, 1919, 2338, 3993, 2119, 1942, 2461, 4814, 18, 1920, 3916, 3]}, "items": [{"id": "p_688", "content": "Crisponi syndrome [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9635, 21851, 1033, 4741, 3, 3]}]}
{"query": {"id": "q_689", "content": "calcium [SEP] cial and extremity tetany. Empirical treatment with intravenous calcium gluconate was initiated, and muscle contractions slowly subside", "tokenized_content": [2, 5016, 3, 24748, 1024, 1930, 14884, 9717, 5323, 18, 9203, 2311, 1956, 7307, 5016, 3351, 8870, 1982, 7796, 16, 1930, 3760, 15465, 11240, 23981, 1021, 3]}, "items": [{"id": "p_689", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_690", "content": "sodium citrate [SEP] s are consistent with a severe reaction to calcium chelation by sodium citrate anticoagulant resulting in symptomatic systemic hypocalcemia. U", "tokenized_content": [2, 5227, 11599, 3, 61, 2032, 3499, 1956, 43, 4010, 3227, 1942, 5016, 28526, 2007, 5227, 11599, 18509, 3864, 1922, 9371, 5510, 30201, 9358, 18, 63, 3]}, "items": [{"id": "p_690", "content": "sodium citrate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5227, 11599, 3, 3]}]}
{"query": {"id": "q_691", "content": "hypocalcemia [SEP]  sodium citrate anticoagulant resulting in symptomatic systemic hypocalcemia. Upon additional retrospective analysis, it was noted that bume", "tokenized_content": [2, 30201, 9358, 3, 5227, 11599, 18509, 3864, 1922, 9371, 5510, 30201, 9358, 18, 4073, 3281, 6968, 2333, 16, 2176, 1982, 5040, 1988, 3168, 3870, 3]}, "items": [{"id": "p_691", "content": "Hypocalcemia [SEP] Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle an", "score": 1, "type": null, "tokenized_content": [2, 30201, 9358, 3, 3378, 1927, 1920, 2877, 5016, 4535, 2791, 18, 10952, 3951, 28704, 6515, 11780, 24064, 16, 2016, 15525, 2156, 2819, 11, 61, 2105, 16, 3760, 1925, 3]}]}
{"query": {"id": "q_692", "content": "loop diuretic [SEP] ional retrospective analysis, it was noted that bumetanide is a loop diuretic that may cause significant hypocalcemia. We conclude that caref", "tokenized_content": [2, 5881, 26829, 3, 4755, 1923, 6968, 2333, 16, 2176, 1982, 5040, 1988, 3168, 14578, 8150, 3695, 1977, 43, 5881, 26829, 1988, 2278, 3936, 2228, 30201, 9358, 18, 2038, 7676, 1988, 3]}, "items": [{"id": "p_692", "content": "Sodium Potassium Chloride Symporter Inhibitors [SEP] Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of t", "score": 1, "type": null, "tokenized_content": [2, 5227, 9057, 9140, 29148, 2718, 1915, 4472, 3, 4820, 1988, 2875, 5227, 17, 9057, 17, 9140, 29148, 2718, 2045, 2154, 2032, 9421, 1922, 1920, 4721, 15871, 7755, 2019, 1920, 6910, 1927, 62, 3]}]}
{"query": {"id": "q_693", "content": "Proteinuria [SEP] Proteinuria after conversion to sirolimus in renal transplant recipients.", "tokenized_content": [2, 15831, 3, 15831, 2256, 7309, 1942, 4520, 24124, 1922, 4604, 5192, 9336, 18, 3]}, "items": [{"id": "p_693", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_694", "content": "sirolimus [SEP] Proteinuria after conversion to sirolimus in renal transplant recipients.", "tokenized_content": [2, 4520, 24124, 3, 15831, 2256, 7309, 1942, 4520, 24124, 1922, 4604, 5192, 9336, 18, 3]}, "items": [{"id": "p_694", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_695", "content": "Sirolimus [SEP] Sirolimus (SRL) is a new, potent immunosuppressive agent. More recently, ", "tokenized_content": [2, 4520, 24124, 3, 4520, 24124, 12, 4581, 1024, 13, 1977, 43, 2814, 16, 6828, 12910, 5899, 18, 2253, 3998, 16, 3]}, "items": [{"id": "p_695", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_696", "content": "SRL [SEP] Sirolimus (SRL) is a new, potent immunosuppressive agent. More recently, prote", "tokenized_content": [2, 4581, 1024, 3, 4520, 24124, 12, 4581, 1024, 13, 1977, 43, 2814, 16, 6828, 12910, 5899, 18, 2253, 3998, 16, 2174, 3]}, "items": [{"id": "p_696", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_697", "content": "proteinuria [SEP]  (SRL) is a new, potent immunosuppressive agent. More recently, proteinuria has been reported as a consequence of sirolimus therapy, althou", "tokenized_content": [2, 15831, 3, 12, 4581, 1024, 13, 1977, 43, 2814, 16, 6828, 12910, 5899, 18, 2253, 3998, 16, 15831, 2258, 2252, 2568, 1966, 43, 7749, 1927, 4520, 24124, 3181, 16, 2874, 3]}, "items": [{"id": "p_697", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_698", "content": "sirolimus [SEP] ore recently, proteinuria has been reported as a consequence of sirolimus therapy, although the mechanism has remained unclear. We retros", "tokenized_content": [2, 4520, 24124, 3, 20237, 3998, 16, 15831, 2258, 2252, 2568, 1966, 43, 7749, 1927, 4520, 24124, 3181, 16, 2876, 1920, 2856, 2258, 5410, 6390, 18, 2038, 7332, 1036, 3]}, "items": [{"id": "p_698", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_699", "content": "chronic allograft nephropathy [SEP] n, 11 women) was treated with SRL as conversion therapy, due to chronic allograft nephropathy (CAN) (n = 15) neoplasia (n = 8); Kaposi's sarcoma, Four skin c", "tokenized_content": [2, 3724, 15941, 15582, 3, 56, 16, 2513, 3089, 13, 1982, 2868, 1956, 4581, 1024, 1966, 7309, 3181, 16, 2810, 1942, 3724, 15941, 15582, 12, 2112, 13, 12, 56, 33, 2461, 3]}, "items": [{"id": "p_699", "content": "Renal Insufficiency, Chronic [SEP] Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is class", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 16, 3724, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1958, 2253, 2254, 2559, 3221, 18, 3724, 5245, 14566, 1977, 2921, 3]}]}
{"query": {"id": "q_700", "content": "CAN [SEP] RL as conversion therapy, due to chronic allograft nephropathy (CAN) (n = 15) neoplasia (n = 8); Kaposi's sarcoma, Four skin cancer", "tokenized_content": [2, 2112, 3, 11929, 1966, 7309, 3181, 16, 2810, 1942, 3724, 15941, 15582, 12, 2112, 13, 12, 56, 33, 2461, 13, 17773, 12, 56, 33, 28, 13, 31, 17367, 27545, 11, 3]}, "items": [{"id": "p_700", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_701", "content": "neoplasia [SEP] on therapy, due to chronic allograft nephropathy (CAN) (n = 15) neoplasia (n = 8); Kaposi's sarcoma, Four skin cancers, One intestinal tu", "tokenized_content": [2, 17773, 3, 1990, 3181, 16, 2810, 1942, 3724, 15941, 15582, 12, 2112, 13, 12, 56, 33, 2461, 13, 17773, 12, 56, 33, 28, 13, 31, 17367, 27545, 11, 61, 13970, 3]}, "items": [{"id": "p_701", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_702", "content": "Kaposi's sarcoma [SEP] chronic allograft nephropathy (CAN) (n = 15) neoplasia (n = 8); Kaposi's sarcoma, Four skin cancers, One intestinal tumors, One renal cell carsi", "tokenized_content": [2, 17367, 27545, 11, 61, 13970, 3, 3724, 15941, 15582, 12, 2112, 13, 12, 56, 33, 2461, 13, 17773, 12, 56, 33, 28, 13, 31, 17367, 27545, 11, 61, 13970, 16, 3]}, "items": [{"id": "p_702", "content": "Sarcoma, Kaposi [SEP] A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, us", "score": 1, "type": null, "tokenized_content": [2, 13970, 16, 17367, 27545, 3, 43, 8844, 14635, 16, 6558, 12847, 4541, 4031, 4378, 2007, 1920, 2740, 1927, 2266, 15641, 17, 2312, 11276, 12128, 16, 2022, 3]}]}
{"query": {"id": "q_703", "content": "skin cancers [SEP] opathy (CAN) (n = 15) neoplasia (n = 8); Kaposi's sarcoma, Four skin cancers, One intestinal tumors, One renal cell carsinom) or BK virus ne", "tokenized_content": [2, 4407, 5717, 3, 20349, 28935, 12, 2112, 13, 12, 56, 33, 2461, 13, 17773, 12, 56, 33, 28, 13, 31, 17367, 27545, 11, 61, 13970, 16, 3006, 4407, 5717, 16, 3]}, "items": [{"id": "p_703", "content": "Skin Neoplasms [SEP] Tumors or cancer of the SKIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4407, 15347, 3, 3861, 2014, 2539, 1927, 1920, 4407, 18, 3]}]}
{"query": {"id": "q_704", "content": "intestinal tumors [SEP] 15) neoplasia (n = 8); Kaposi's sarcoma, Four skin cancers, One intestinal tumors, One renal cell carsinom) or BK virus nephropathy (n = 2). SRL ", "tokenized_content": [2, 6139, 3861, 3, 2461, 13, 17773, 12, 56, 33, 28, 13, 31, 17367, 27545, 11, 61, 13970, 16, 3006, 4407, 5717, 16, 2340, 6139, 3861, 16, 2340, 4604, 2024, 23985, 3]}, "items": [{"id": "p_704", "content": "Intestinal Neoplasms [SEP] Tumors or cancer of the INTESTINES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6139, 15347, 3, 3861, 2014, 2539, 1927, 1920, 26610, 18, 3]}]}
{"query": {"id": "q_705", "content": "renal cell carsinom [SEP] Kaposi's sarcoma, Four skin cancers, One intestinal tumors, One renal cell carsinom) or BK virus nephropathy (n = 2). SRL was started at a mean of ", "tokenized_content": [2, 4604, 2024, 23985, 3522, 1035, 3, 17367, 27545, 11, 61, 13970, 16, 3006, 4407, 5717, 16, 2340, 6139, 3861, 16, 2340, 4604, 2024, 23985, 3522, 1035, 13, 2014, 13702, 3413, 3]}, "items": [{"id": "p_705", "content": "Carcinoma, Renal Cell [SEP] A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes includin", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 4604, 2024, 3, 43, 8538, 2210, 1927, 13088, 2014, 16321, 5373, 3595, 2037, 2094, 1927, 1920, 11770, 18, 2276, 2032, 2980, 8160, 2327, 1921, 3]}]}
{"query": {"id": "q_706", "content": "nephropathy [SEP] reated with SRL as conversion therapy, due to chronic allograft nephropathy (CAN) (n = 15) neoplasia (n = 8); Kaposi's sarcoma, Four skin c", "tokenized_content": [2, 15582, 3, 1964, 1981, 1956, 4581, 1024, 1966, 7309, 3181, 16, 2810, 1942, 3724, 15941, 15582, 12, 2112, 13, 12, 56, 33, 2461, 13, 17773, 12, 56, 33, 28, 13, 3]}, "items": [{"id": "p_706", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_707", "content": "Proteinuria [SEP] . Mean follow-up on SRL therapy was 20 +/- 12 (6 to 43) months. Proteinuria increased from 0.445 (0 to 1.5) g/d before conversion to 3.2 g/", "tokenized_content": [2, 15831, 3, 18, 2667, 2396, 17, 2353, 1990, 4581, 1024, 3181, 1982, 2036, 15, 19, 17, 2369, 12, 26, 1942, 3941, 13, 3221, 18, 15831, 2502, 2037, 20, 18, 28821, 3]}, "items": [{"id": "p_707", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_708", "content": "nephrotic [SEP] y-eight percent of patients showed increased proteinuria to the nephrotic range. Biopsies performed in five patients revealed new patholo", "tokenized_content": [2, 29646, 3, 67, 17, 5066, 3564, 1927, 2132, 2594, 2502, 15831, 1942, 1920, 29646, 3109, 18, 9782, 2593, 1922, 3628, 2132, 3404, 2814, 2450, 26356, 3]}, "items": [{"id": "p_708", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_709", "content": "membranoproliferative glomerulopathy [SEP] rformed in five patients revealed new pathological changes: One membranoproliferative glomerulopathy and interstitial nephritis. These patients showed persistently ", "tokenized_content": [2, 3033, 9286, 19421, 19268, 6522, 3, 7751, 2076, 1919, 1922, 3628, 2132, 3404, 2814, 6598, 2840, 30, 2340, 3033, 9286, 19421, 19268, 6522, 1930, 11584, 25064, 18, 2144, 2132, 2594, 3]}, "items": [{"id": "p_709", "content": "Glomerulonephritis, Membranous [SEP] A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) o", "score": 1, "type": null, "tokenized_content": [2, 27057, 16, 22890, 3, 43, 2601, 1927, 27057, 1988, 1977, 4378, 2007, 1920, 4858, 1927, 3743, 14371, 12, 5508, 3260, 8926, 2796, 13, 57, 3]}]}
{"query": {"id": "q_710", "content": "interstitial nephritis [SEP] hological changes: One membranoproliferative glomerulopathy and interstitial nephritis. These patients showed persistently good graft function. Serum ", "tokenized_content": [2, 11584, 25064, 3, 20403, 11545, 1923, 2840, 30, 2340, 3033, 9286, 19421, 19268, 6522, 1930, 11584, 25064, 18, 2144, 2132, 2594, 23334, 4227, 7668, 2347, 18, 3256, 3]}, "items": [{"id": "p_710", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_711", "content": "creatinine [SEP] . These patients showed persistently good graft function. Serum creatinine values did not change significantly: 1.98 +/- 0.8 mg/dL before ", "tokenized_content": [2, 9374, 3, 18, 2144, 2132, 2594, 23334, 4227, 7668, 2347, 18, 3256, 9374, 2851, 2811, 2084, 3185, 2567, 30, 21, 18, 5613, 15, 19, 17, 20, 18, 28, 2786, 19, 3]}, "items": [{"id": "p_711", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_712", "content": "cyclophosphamide [SEP] haracterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat.", "tokenized_content": [2, 17135, 3, 4303, 2422, 2466, 1927, 23984, 1930, 11739, 3387, 1922, 17135, 17, 2719, 9446, 3678, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_712", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_713", "content": "cystitis [SEP] mpathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat.", "tokenized_content": [2, 9446, 3678, 3, 12888, 22493, 1930, 11739, 3387, 1922, 17135, 17, 2719, 9446, 3678, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_713", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_714", "content": "cyclophosphamide [SEP] In cyclophosphamide-induced cystitis in the rat, detrusor function is impaired and ", "tokenized_content": [2, 17135, 3, 1922, 17135, 17, 2719, 9446, 3678, 1922, 1920, 3067, 16, 11086, 1957, 1924, 2347, 1977, 5761, 1930, 3]}, "items": [{"id": "p_714", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_715", "content": "cystitis [SEP] In cyclophosphamide-induced cystitis in the rat, detrusor function is impaired and the expression an", "tokenized_content": [2, 9446, 3678, 3, 1922, 17135, 17, 2719, 9446, 3678, 1922, 1920, 3067, 16, 11086, 1957, 1924, 2347, 1977, 5761, 1930, 1920, 2294, 1925, 3]}, "items": [{"id": "p_715", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_716", "content": "atropine [SEP] nic, adrenergic and purinergic receptor antagonists. Generally, atropine reduced contractions, but in contrast to controls, it also redu", "tokenized_content": [2, 24031, 3, 11188, 16, 13672, 1930, 19700, 1005, 11545, 3148, 10515, 18, 4933, 16, 24031, 3028, 15465, 16, 2308, 1922, 3320, 1942, 3562, 16, 2176, 2222, 2312, 1032, 3]}, "items": [{"id": "p_716", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_717", "content": "alpha,beta-methylene adenosine-5'-triphosphate [SEP]  preparations. In both types, purinoceptor desensitization with alpha,beta-methylene adenosine-5'-triphosphate (alpha,beta-meATP) caused further reductions at low frequencies", "tokenized_content": [2, 4595, 16, 4666, 17, 17947, 10125, 17, 25, 11, 17, 17978, 3, 9815, 18, 1922, 2321, 3584, 16, 2992, 3522, 3342, 1924, 19008, 1956, 4595, 16, 4666, 17, 17947, 10125, 3]}, "items": [{"id": "p_717", "content": "alpha,beta-methyleneadenosine 5'-triphosphate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4595, 16, 4666, 17, 17947, 10185, 7506, 25, 11, 17, 17978, 3, 3]}]}
{"query": {"id": "q_718", "content": "alpha,beta-meATP [SEP] sitization with alpha,beta-methylene adenosine-5'-triphosphate (alpha,beta-meATP) caused further reductions at low frequencies (<10 Hz). The mus", "tokenized_content": [2, 4595, 16, 4666, 17, 12040, 1034, 3, 14949, 2466, 1956, 4595, 16, 4666, 17, 17947, 10125, 17, 25, 11, 17, 17978, 12, 4595, 16, 4666, 17, 12040, 1034, 13, 4189, 3]}, "items": [{"id": "p_718", "content": "alpha,beta-methyleneadenosine 5'-triphosphate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4595, 16, 4666, 17, 17947, 10185, 7506, 25, 11, 17, 17978, 3, 3]}]}
{"query": {"id": "q_719", "content": "4-diphenylacetoxy-N-methylpiperidine [SEP] uencies (<10 Hz). The muscarinic receptor antagonists atropine, 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) ('M(1)/M(3)/M(5)-selective'), methoctramine ('M(2)-sel", "tokenized_content": [2, 24, 17, 18190, 7681, 7221, 17, 56, 17, 4963, 10984, 2116, 5802, 3, 63, 4738, 12, 32, 2119, 4865, 13, 18, 1920, 20318, 3148, 10515, 24031, 16, 24, 17, 18190, 3]}, "items": [{"id": "p_719", "content": "4-diphenylacetoxy-1,1-dimethylpiperidinium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 18190, 7681, 7221, 17, 21, 16, 21, 17, 9780, 10984, 2116, 24233, 3, 3]}]}
{"query": {"id": "q_720", "content": "4-DAMP [SEP] tor antagonists atropine, 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) ('M(1)/M(3)/M(5)-selective'), methoctramine ('M(2)-selective')", "tokenized_content": [2, 24, 17, 15515, 3, 8184, 10515, 24031, 16, 24, 17, 18190, 7681, 7221, 17, 56, 17, 4963, 10984, 2116, 5802, 12, 24, 17, 15515, 13, 12, 11, 55, 12, 21, 3]}, "items": [{"id": "p_720", "content": "4-diphenylacetoxy-1,1-dimethylpiperidinium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 18190, 7681, 7221, 17, 21, 16, 21, 17, 9780, 10984, 2116, 24233, 3, 3]}]}
{"query": {"id": "q_721", "content": "methoctramine [SEP] etoxy-N-methylpiperidine (4-DAMP) ('M(1)/M(3)/M(5)-selective'), methoctramine ('M(2)-selective') and pirenzepine ('M(1)-selective') antagoniz", "tokenized_content": [2, 2295, 24402, 29085, 2053, 3, 2140, 7221, 17, 56, 17, 4963, 10984, 2116, 5802, 12, 24, 17, 15515, 13, 12, 11, 55, 12, 21, 13, 19, 55, 12, 23, 13, 3]}, "items": [{"id": "p_721", "content": "methoctramine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2295, 24402, 29085, 2053, 3, 3]}]}
{"query": {"id": "q_722", "content": "pirenzepine [SEP] (1)/M(3)/M(5)-selective'), methoctramine ('M(2)-selective') and pirenzepine ('M(1)-selective') antagonized the tonic component of the elect", "tokenized_content": [2, 13774, 4389, 2128, 2053, 3, 12, 21, 13, 19, 55, 12, 23, 13, 19, 55, 12, 25, 13, 17, 5328, 11, 13, 16, 2295, 24402, 29085, 2053, 12, 11, 55, 3]}, "items": [{"id": "p_722", "content": "Pirenzepine [SEP] An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, sa", "score": 1, "type": null, "tokenized_content": [2, 13774, 4389, 2128, 2053, 3, 1925, 20330, 7801, 18979, 5899, 1988, 7042, 6319, 5512, 2019, 2826, 5312, 2254, 2032, 3414, 1942, 4081, 8375, 9254, 16, 4611, 3]}]}
{"query": {"id": "q_723", "content": "carbachol [SEP]  the tonic responses at high frequencies. While contractions to carbachol and ATP were the same in inflamed and in control strips when re", "tokenized_content": [2, 28940, 3, 1920, 16887, 3387, 2019, 2149, 6458, 18, 2679, 15465, 1942, 28940, 1930, 4498, 1985, 1920, 2841, 1922, 18881, 1930, 1922, 2285, 18721, 2469, 1964, 3]}, "items": [{"id": "p_723", "content": "Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28940, 3, 43, 11240, 21665, 13908, 7829, 1988, 8016, 2019, 2321, 20318, 1930, 20239, 4086, 18, 3]}]}
{"query": {"id": "q_724", "content": "ATP [SEP] th alpha,beta-methylene adenosine-5'-triphosphate (alpha,beta-meATP) caused further reductions at low frequencies (<10 Hz). The mus", "tokenized_content": [2, 4498, 3, 1913, 4595, 16, 4666, 17, 17947, 10125, 17, 25, 11, 17, 17978, 12, 4595, 16, 4666, 17, 12040, 1034, 13, 4189, 2520, 9350, 2019, 2330, 6458, 12, 32, 3]}, "items": [{"id": "p_724", "content": "Adenosine Triphosphate [SEP] An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in meta", "score": 1, "type": null, "tokenized_content": [2, 10125, 17978, 3, 1925, 15643, 5489, 3165, 2559, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 18, 1922, 2459, 1942, 2496, 6608, 5456, 1922, 5880, 3]}]}
{"query": {"id": "q_725", "content": "potassium [SEP] e in inflamed and in control strips when related to a reference potassium response, isoprenaline-induced relaxations were smaller in infl", "tokenized_content": [2, 9057, 3, 47, 1922, 18881, 1930, 1922, 2285, 18721, 2469, 2712, 1942, 43, 4386, 9057, 2644, 16, 26690, 8177, 17, 2719, 9157, 1036, 1985, 5322, 1922, 2552, 3]}, "items": [{"id": "p_725", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_726", "content": "isoprenaline [SEP]  control strips when related to a reference potassium response, isoprenaline-induced relaxations were smaller in inflamed strips. Thus, in c", "tokenized_content": [2, 26690, 8177, 3, 2285, 18721, 2469, 2712, 1942, 43, 4386, 9057, 2644, 16, 26690, 8177, 17, 2719, 9157, 1036, 1985, 5322, 1922, 18881, 18721, 18, 2842, 16, 1922, 45, 3]}, "items": [{"id": "p_726", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_727", "content": "benzodiazepines [SEP] Associations between use of benzodiazepines or related drugs and health, physical abilities and cognitive f", "tokenized_content": [2, 26555, 3, 5253, 2192, 2485, 1927, 26555, 2014, 2712, 4195, 1930, 2436, 16, 3841, 10957, 1930, 4328, 48, 3]}, "items": [{"id": "p_727", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_728", "content": "benzodiazepines [SEP] OBJECTIVE: To describe associations between the use of benzodiazepines or related drugs (BZDs/RDs) and health, functional abilities an", "tokenized_content": [2, 26555, 3, 4470, 30, 1942, 5993, 5253, 2192, 1920, 2485, 1927, 26555, 2014, 2712, 4195, 12, 15225, 3134, 19, 25503, 13, 1930, 2436, 16, 3183, 10957, 1925, 3]}, "items": [{"id": "p_728", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_729", "content": "BZDs [SEP] sociations between the use of benzodiazepines or related drugs (BZDs/RDs) and health, functional abilities and cognitive function in", "tokenized_content": [2, 15225, 3134, 3, 4744, 2082, 2192, 1920, 2485, 1927, 26555, 2014, 2712, 4195, 12, 15225, 3134, 19, 25503, 13, 1930, 2436, 16, 3183, 10957, 1930, 4328, 2347, 1922, 3]}, "items": [{"id": "p_729", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_730", "content": "oxazepam [SEP] for confounding variables. The residual serum concentrations of oxazepam, temazepam and zopiclone were analysed. RESULTS: The mean +/- S", "tokenized_content": [2, 28905, 6931, 4302, 1035, 3, 1958, 10451, 3832, 18, 1920, 6615, 3256, 3295, 1927, 28905, 6931, 4302, 1035, 16, 2775, 28231, 1930, 11906, 19232, 6012, 2912, 1985, 6450, 18, 2274, 3]}, "items": [{"id": "p_730", "content": "Oxazepam [SEP] A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28905, 6931, 4302, 1035, 3, 43, 27266, 2251, 1922, 1920, 2311, 1927, 5592, 16, 4284, 9594, 16, 1930, 16882, 18, 3]}]}
{"query": {"id": "q_731", "content": "temazepam [SEP] nding variables. The residual serum concentrations of oxazepam, temazepam and zopiclone were analysed. RESULTS: The mean +/- SD duration ", "tokenized_content": [2, 2775, 28231, 3, 8026, 1941, 3832, 18, 1920, 6615, 3256, 3295, 1927, 28905, 6931, 4302, 1035, 16, 2775, 28231, 1930, 11906, 19232, 6012, 2912, 1985, 6450, 18, 2274, 30, 1920, 3]}, "items": [{"id": "p_731", "content": "Temazepam [SEP] A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2775, 28231, 3, 43, 27266, 1988, 8016, 1966, 43, 7034, 17, 29093, 2687, 18521, 1930, 2246, 17, 5592, 5899, 18, 3]}]}
{"query": {"id": "q_732", "content": "zopiclone [SEP] s. The residual serum concentrations of oxazepam, temazepam and zopiclone were analysed. RESULTS: The mean +/- SD duration of BZD/RD use ", "tokenized_content": [2, 11906, 19232, 6012, 2912, 3, 61, 18, 1920, 6615, 3256, 3295, 1927, 28905, 6931, 4302, 1035, 16, 2775, 28231, 1930, 11906, 19232, 6012, 2912, 1985, 6450, 18, 2274, 30, 1920, 3]}, "items": [{"id": "p_732", "content": "zopiclone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11906, 19232, 6012, 2912, 3, 3]}]}
{"query": {"id": "q_733", "content": "dementia [SEP] ith effects on the CNS, which tended to be related to diagnosed dementia. After adjustment for these variables as confounders, use of BZ", "tokenized_content": [2, 7811, 3, 24737, 2564, 1990, 1920, 7520, 16, 2154, 10587, 1942, 1998, 2712, 1942, 5377, 7811, 18, 2256, 7970, 1958, 2144, 3832, 1966, 14140, 16, 2485, 1927, 15225, 3]}, "items": [{"id": "p_733", "content": "Dementia [SEP] An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occup", "score": 1, "type": null, "tokenized_content": [2, 7811, 3, 1925, 5815, 6805, 5018, 4770, 1956, 3257, 1927, 13059, 10957, 1927, 5409, 5155, 1942, 11827, 1956, 3686, 2014, 6027, 3]}]}
{"query": {"id": "q_734", "content": "dizziness [SEP] sured by the MMSE. However, use of BZDs/RDs was associated with dizziness, inability to sleep after awaking at night and tiredness in the", "tokenized_content": [2, 24009, 3, 16320, 1007, 2007, 1920, 18043, 18, 2406, 16, 2485, 1927, 15225, 3134, 19, 25503, 1982, 2458, 1956, 24009, 16, 11752, 1942, 5006, 2256, 27962, 1941, 2019, 9609, 1930, 3]}, "items": [{"id": "p_734", "content": "Dizziness [SEP] An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24009, 3, 1925, 26385, 2870, 2576, 2154, 2278, 3333, 1942, 43, 7534, 1927, 5067, 2054, 29292, 16, 6269, 1927, 1920, 3515, 16, 2014, 3696, 10611, 1919, 2971, 18, 3]}]}
{"query": {"id": "q_735", "content": "inability to sleep [SEP] e MMSE. However, use of BZDs/RDs was associated with dizziness, inability to sleep after awaking at night and tiredness in the mornings during the", "tokenized_content": [2, 11752, 1942, 5006, 3, 47, 18043, 18, 2406, 16, 2485, 1927, 15225, 3134, 19, 25503, 1982, 2458, 1956, 24009, 16, 11752, 1942, 5006, 2256, 27962, 1941, 2019, 9609, 1930, 16661, 3]}, "items": [{"id": "p_735", "content": "Sleep Initiation and Maintenance Disorders [SEP] Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in a", "score": 1, "type": null, "tokenized_content": [2, 5006, 6035, 1930, 6291, 4414, 3, 4414, 4378, 2007, 6159, 1927, 1920, 3682, 1942, 11051, 2014, 6698, 5006, 18, 2052, 2278, 4704, 1966, 43, 3065, 4770, 2014, 1922, 43, 3]}]}
{"query": {"id": "q_736", "content": "tiredness [SEP] d with dizziness, inability to sleep after awaking at night and tiredness in the mornings during the week prior to admission and with str", "tokenized_content": [2, 16661, 1919, 2971, 3, 46, 1956, 24009, 16, 11752, 1942, 5006, 2256, 27962, 1941, 2019, 9609, 1930, 16661, 1919, 2971, 1922, 1920, 12661, 1036, 2409, 1920, 2982, 3432, 1942, 7682, 3]}, "items": [{"id": "p_736", "content": "Fatigue [SEP] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and re", "score": 1, "type": null, "tokenized_content": [2, 8656, 3, 1920, 3360, 1927, 12615, 8254, 2894, 43, 3047, 1927, 28187, 16, 5018, 2014, 3841, 16, 4378, 2007, 43, 3261, 4796, 1958, 2778, 1930, 1964, 3]}]}
{"query": {"id": "q_737", "content": "depressive symptoms [SEP] e mornings during the week prior to admission and with stronger depressive symptoms measured at the beginning of the hospital stay. Use of BZDs/RDs", "tokenized_content": [2, 7745, 3601, 3, 47, 12661, 1036, 2409, 1920, 2982, 3432, 1942, 7682, 1930, 1956, 7926, 7745, 3601, 3045, 2019, 1920, 7828, 1927, 1920, 3461, 8094, 18, 2485, 1927, 15225, 3134, 3]}, "items": [{"id": "p_737", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_738", "content": "vocal fold palsy [SEP] Acute vocal fold palsy after acute disulfiram intoxication.", "tokenized_content": [2, 13115, 3728, 18698, 3, 3939, 13115, 3728, 18698, 2256, 3939, 10993, 11979, 1035, 20965, 18, 3]}, "items": [{"id": "p_738", "content": "Vocal Cord Paralysis [SEP] Congenital or acquired paralysis of one or both VOCAL CORDS. This condition is caused by defects in the CENTRAL NERVOUS SYSTEM, ", "score": 1, "type": null, "tokenized_content": [2, 13115, 6670, 18973, 3, 9901, 2014, 5815, 18973, 1927, 2340, 2014, 2321, 13115, 23353, 18, 2052, 2625, 1977, 4189, 2007, 6007, 1922, 1920, 4101, 7580, 2433, 16, 3]}]}
{"query": {"id": "q_739", "content": "disulfiram [SEP] Acute vocal fold palsy after acute disulfiram intoxication.", "tokenized_content": [2, 10993, 11979, 1035, 3, 3939, 13115, 3728, 18698, 2256, 3939, 10993, 11979, 1035, 20965, 18, 3]}, "items": [{"id": "p_739", "content": "Disulfiram [SEP] A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly", "score": 1, "type": null, "tokenized_content": [2, 10993, 11979, 1035, 3, 43, 17742, 2010, 10533, 2251, 1966, 1925, 4284, 10641, 2825, 1031, 18, 2176, 1977, 43, 4322, 18037, 10605, 7311, 2469, 5254, 4298, 16, 2308, 7686, 3]}]}
{"query": {"id": "q_740", "content": "peripheral neuropathy [SEP] Acute peripheral neuropathy caused by a disulfiram overdose is very rare and there is no re", "tokenized_content": [2, 5009, 13177, 3, 3939, 5009, 13177, 4189, 2007, 43, 10993, 11979, 1035, 21090, 1977, 3345, 5844, 1930, 2276, 1977, 2239, 1964, 3]}, "items": [{"id": "p_740", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_741", "content": "disulfiram [SEP] Acute peripheral neuropathy caused by a disulfiram overdose is very rare and there is no report of it leading to v", "tokenized_content": [2, 10993, 11979, 1035, 3, 3939, 5009, 13177, 4189, 2007, 43, 10993, 11979, 1035, 21090, 1977, 3345, 5844, 1930, 2276, 1977, 2239, 3809, 1927, 2176, 4523, 1942, 64, 3]}, "items": [{"id": "p_741", "content": "Disulfiram [SEP] A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly", "score": 1, "type": null, "tokenized_content": [2, 10993, 11979, 1035, 3, 43, 17742, 2010, 10533, 2251, 1966, 1925, 4284, 10641, 2825, 1031, 18, 2176, 1977, 43, 4322, 18037, 10605, 7311, 2469, 5254, 4298, 16, 2308, 7686, 3]}]}
{"query": {"id": "q_742", "content": "overdose [SEP] Acute peripheral neuropathy caused by a disulfiram overdose is very rare and there is no report of it leading to vocal fold", "tokenized_content": [2, 21090, 3, 3939, 5009, 13177, 4189, 2007, 43, 10993, 11979, 1035, 21090, 1977, 3345, 5844, 1930, 2276, 1977, 2239, 3809, 1927, 2176, 4523, 1942, 13115, 3728, 3]}, "items": [{"id": "p_742", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_743", "content": "vocal fold palsy [SEP] m overdose is very rare and there is no report of it leading to vocal fold palsy. A 49-year-old woman was transferred to our department because ", "tokenized_content": [2, 13115, 3728, 18698, 3, 55, 21090, 1977, 3345, 5844, 1930, 2276, 1977, 2239, 3809, 1927, 2176, 4523, 1942, 13115, 3728, 18698, 18, 43, 4343, 17, 2476, 17, 4156, 10440, 1982, 3]}, "items": [{"id": "p_743", "content": "Vocal Cord Paralysis [SEP] Congenital or acquired paralysis of one or both VOCAL CORDS. This condition is caused by defects in the CENTRAL NERVOUS SYSTEM, ", "score": 1, "type": null, "tokenized_content": [2, 13115, 6670, 18973, 3, 9901, 2014, 5815, 18973, 1927, 2340, 2014, 2321, 13115, 23353, 18, 2052, 2625, 1977, 4189, 2007, 6007, 1922, 1920, 4101, 7580, 2433, 16, 3]}]}
{"query": {"id": "q_744", "content": "quadriparesis [SEP]  49-year-old woman was transferred to our department because of quadriparesis, lancinating pain, sensory loss, and paresthesia of the distal ", "tokenized_content": [2, 10264, 19514, 2808, 1937, 3, 4343, 17, 2476, 17, 4156, 10440, 1982, 6311, 1942, 2342, 6143, 2882, 1927, 10264, 19514, 2808, 1937, 16, 26448, 9691, 3594, 16, 6893, 3257, 16, 3]}, "items": [{"id": "p_744", "content": "Quadriplegia [SEP] Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHER", "score": 1, "type": null, "tokenized_content": [2, 10264, 13229, 6541, 2126, 3, 4010, 2014, 4080, 3257, 1927, 4842, 2347, 1922, 2136, 3006, 14054, 2154, 2278, 3211, 2037, 3068, 3902, 31, 6071, 6670, 3902, 31, 4709, 3]}]}
{"query": {"id": "q_745", "content": "pain [SEP] sferred to our department because of quadriparesis, lancinating pain, sensory loss, and paresthesia of the distal limbs. One month p", "tokenized_content": [2, 3594, 3, 6347, 5385, 1919, 1942, 2342, 6143, 2882, 1927, 10264, 19514, 2808, 1937, 16, 26448, 9691, 3594, 16, 6893, 3257, 16, 1930, 2096, 29259, 1927, 1920, 6583, 14054, 18, 3]}, "items": [{"id": "p_745", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_746", "content": "sensory loss [SEP] d to our department because of quadriparesis, lancinating pain, sensory loss, and paresthesia of the distal limbs. One month previously, she", "tokenized_content": [2, 6893, 3257, 3, 46, 1942, 2342, 6143, 2882, 1927, 10264, 19514, 2808, 1937, 16, 26448, 9691, 3594, 16, 6893, 3257, 16, 1930, 2096, 29259, 1927, 1920, 6583, 14054, 18, 2340, 3]}, "items": [{"id": "p_746", "content": "Hereditary Sensory and Autonomic Neuropathy Type Ie [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16321, 6893, 1930, 13725, 13177, 2601, 10116, 3, 3]}]}
{"query": {"id": "q_747", "content": "paresthesia [SEP] t because of quadriparesis, lancinating pain, sensory loss, and paresthesia of the distal limbs. One month previously, she had taken a sing", "tokenized_content": [2, 2096, 29259, 3, 62, 2882, 1927, 10264, 19514, 2808, 1937, 16, 26448, 9691, 3594, 16, 6893, 3257, 16, 1930, 2096, 29259, 1927, 1920, 6583, 14054, 18, 2340, 2935, 3024, 16, 3]}, "items": [{"id": "p_747", "content": "Paresthesia [SEP] Subjective cutaneous sensations (e.g., cold, warmth, tingling, pressure, etc.) that are experienced spontaneously in the absence", "score": 1, "type": null, "tokenized_content": [2, 2096, 29259, 3, 9106, 11276, 26498, 12, 47, 18, 49, 18, 16, 6685, 16, 10142, 1963, 16, 12347, 4365, 1941, 16, 3772, 16, 8289, 18, 13, 1988, 2032, 6090, 12753, 1922, 1920, 3905, 3]}]}
{"query": {"id": "q_748", "content": "ALCOHOL [SEP]  she had taken a single high dose of disulfiram (130 tablets of ALCOHOL STOP TAB, Shin-Poong Pharm. Co., Ansan, Korea) in a suicide att", "tokenized_content": [2, 4284, 3, 4693, 2430, 4208, 43, 2957, 2149, 3253, 1927, 10993, 11979, 1035, 12, 8761, 16576, 1927, 4284, 6875, 8514, 16, 23403, 17, 2510, 2188, 3988, 18, 2081, 18, 16, 3]}, "items": [{"id": "p_748", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_749", "content": "ataxia [SEP] ingestion, she was in a confused state and had mild to moderate ataxia and giddiness. She noticed hoarseness and distally accentuated ", "tokenized_content": [2, 17698, 3, 14195, 16, 4693, 1982, 1922, 43, 30190, 3360, 1930, 2430, 5809, 1942, 5086, 17698, 1930, 7217, 10882, 8254, 18, 4693, 14114, 6673, 11005, 2971, 1930, 28199, 26884, 20312, 3]}, "items": [{"id": "p_749", "content": "Ataxia [SEP] Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes,", "score": 1, "type": null, "tokenized_content": [2, 17698, 3, 6159, 1927, 1920, 3682, 1942, 2385, 6689, 1954, 11651, 13225, 8264, 18, 2052, 2625, 2278, 4081, 1920, 14054, 16, 13717, 16, 7127, 16, 3]}]}
{"query": {"id": "q_750", "content": "giddiness [SEP] she was in a confused state and had mild to moderate ataxia and giddiness. She noticed hoarseness and distally accentuated motor and sens", "tokenized_content": [2, 7217, 10882, 8254, 3, 4693, 1982, 1922, 43, 30190, 3360, 1930, 2430, 5809, 1942, 5086, 17698, 1930, 7217, 10882, 8254, 18, 4693, 14114, 6673, 11005, 2971, 1930, 28199, 26884, 20312, 3]}, "items": [{"id": "p_750", "content": "Dizziness [SEP] An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24009, 3, 1925, 26385, 2870, 2576, 2154, 2278, 3333, 1942, 43, 7534, 1927, 5067, 2054, 29292, 16, 6269, 1927, 1920, 3515, 16, 2014, 3696, 10611, 1919, 2971, 18, 3]}]}
{"query": {"id": "q_751", "content": "hoarseness [SEP] tate and had mild to moderate ataxia and giddiness. She noticed hoarseness and distally accentuated motor and sensory dysfunction after sh", "tokenized_content": [2, 6673, 11005, 2971, 3, 10687, 1021, 1930, 2430, 5809, 1942, 5086, 17698, 1930, 7217, 10882, 8254, 18, 4693, 14114, 6673, 11005, 2971, 1930, 28199, 26884, 20312, 4842, 1930, 6893, 5273, 3]}, "items": [{"id": "p_751", "content": "Hoarseness [SEP] An unnaturally deep or rough quality of voice.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6673, 11005, 2971, 3, 1925, 15002, 1926, 7378, 6515, 2014, 9204, 3455, 1927, 15690, 18, 3]}]}
{"query": {"id": "q_752", "content": "polyneuropathy [SEP] conduction study was consistent with severe sensorimotor axonal polyneuropathy. Laryngeal electromyography (thyroarytenoid muscle) showed ampl", "tokenized_content": [2, 15176, 3708, 13117, 3, 12382, 2161, 1982, 3499, 1956, 4010, 18395, 10623, 15176, 3708, 13117, 18, 18418, 22755, 3796, 12, 16993, 2141, 2777, 2642, 3760, 13, 2594, 3735, 3]}, "items": [{"id": "p_752", "content": "Polyneuropathies [SEP] Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral dist", "score": 1, "type": null, "tokenized_content": [2, 15176, 3708, 7262, 2062, 3, 3902, 1927, 3137, 5009, 12014, 7159, 18, 15176, 3708, 7262, 2062, 5394, 2032, 4378, 2007, 20410, 16, 7787, 3653, 3]}]}
{"query": {"id": "q_753", "content": "palsy [SEP] is very rare and there is no report of it leading to vocal fold palsy. A 49-year-old woman was transferred to our department because ", "tokenized_content": [2, 18698, 3, 1977, 3345, 5844, 1930, 2276, 1977, 2239, 3809, 1927, 2176, 4523, 1942, 13115, 3728, 18698, 18, 43, 4343, 17, 2476, 17, 4156, 10440, 1982, 6311, 1942, 2342, 6143, 3]}, "items": [{"id": "p_753", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_754", "content": "thrombosis [SEP] Higher optical density of an antigen assay predicts thrombosis in patients with heparin-induced thrombocytopenia.", "tokenized_content": [2, 11354, 3, 2580, 6322, 3824, 1927, 1925, 4730, 3381, 12027, 11354, 1922, 2132, 1956, 9962, 17, 2719, 17100, 18, 3]}, "items": [{"id": "p_754", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_755", "content": "heparin [SEP] ensity of an antigen assay predicts thrombosis in patients with heparin-induced thrombocytopenia.", "tokenized_content": [2, 9962, 3, 4847, 1999, 1927, 1925, 4730, 3381, 12027, 11354, 1922, 2132, 1956, 9962, 17, 2719, 17100, 18, 3]}, "items": [{"id": "p_755", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_756", "content": "thrombocytopenia [SEP] igen assay predicts thrombosis in patients with heparin-induced thrombocytopenia.", "tokenized_content": [2, 17100, 3, 10777, 1022, 3381, 12027, 11354, 1922, 2132, 1956, 9962, 17, 2719, 17100, 18, 3]}, "items": [{"id": "p_756", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_757", "content": "heparin [SEP]  correlate optical density and percent inhibition of a two-step heparin-induced thrombocytopenia (HIT) antigen assay with thrombosis; t", "tokenized_content": [2, 9962, 3, 8474, 6322, 3824, 1930, 3564, 3523, 1927, 43, 2288, 17, 3537, 9962, 17, 2719, 17100, 12, 11314, 13, 4730, 3381, 1956, 11354, 31, 62, 3]}, "items": [{"id": "p_757", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_758", "content": "thrombocytopenia [SEP] al density and percent inhibition of a two-step heparin-induced thrombocytopenia (HIT) antigen assay with thrombosis; the assay utilizes reactio", "tokenized_content": [2, 17100, 3, 1969, 3824, 1930, 3564, 3523, 1927, 43, 2288, 17, 3537, 9962, 17, 2719, 17100, 12, 11314, 13, 4730, 3381, 1956, 11354, 31, 1920, 3381, 18127, 9793, 3940, 3]}, "items": [{"id": "p_758", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_759", "content": "HIT [SEP] cent inhibition of a two-step heparin-induced thrombocytopenia (HIT) antigen assay with thrombosis; the assay utilizes reaction inh", "tokenized_content": [2, 11314, 3, 3208, 3523, 1927, 43, 2288, 17, 3537, 9962, 17, 2719, 17100, 12, 11314, 13, 4730, 3381, 1956, 11354, 31, 1920, 3381, 18127, 3227, 11035, 3]}, "items": [{"id": "p_759", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_760", "content": "thrombosis [SEP] -step heparin-induced thrombocytopenia (HIT) antigen assay with thrombosis; the assay utilizes reaction inhibition characteristics of a hi", "tokenized_content": [2, 11354, 3, 17, 3537, 9962, 17, 2719, 17100, 12, 11314, 13, 4730, 3381, 1956, 11354, 31, 1920, 3381, 18127, 3227, 3523, 3779, 1927, 43, 10220, 3]}, "items": [{"id": "p_760", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_761", "content": "thrombotic [SEP]  a 2.8-fold increased risk of thrombosis in females. Similarly, thrombotic risk increased with age and OD values. CONCLUSION: Higher OD is", "tokenized_content": [2, 21039, 3, 43, 22, 18, 28, 17, 3728, 2502, 2565, 1927, 11354, 1922, 5027, 18, 4852, 16, 21039, 2565, 2502, 1956, 2632, 1930, 4426, 2851, 18, 4180, 30, 2580, 4426, 3]}, "items": [{"id": "p_761", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_762", "content": "retinal vein occlusion [SEP] Central retinal vein occlusion associated with clomiphene-induced ovulation.", "tokenized_content": [2, 6943, 7920, 10543, 3, 4101, 6943, 7920, 10543, 2458, 1956, 12596, 7395, 17616, 1021, 17, 2719, 21496, 18, 3]}, "items": [{"id": "p_762", "content": "Retinal Vein Occlusion [SEP] Blockage of the RETINAL VEIN. Those at high risk for this condition include patients with HYPERTENSION; DIABETES MELLITUS; ATHER", "score": 1, "type": null, "tokenized_content": [2, 6943, 7920, 10543, 3, 23615, 1927, 1920, 6943, 7920, 18, 2690, 2019, 2149, 2565, 1958, 2052, 2625, 3951, 2132, 1956, 5579, 31, 4032, 9695, 31, 7274, 3]}]}
{"query": {"id": "q_763", "content": "clomiphene [SEP] Central retinal vein occlusion associated with clomiphene-induced ovulation.", "tokenized_content": [2, 12596, 7395, 17616, 1021, 3, 4101, 6943, 7920, 10543, 2458, 1956, 12596, 7395, 17616, 1021, 17, 2719, 21496, 18, 3]}, "items": [{"id": "p_763", "content": "Clomiphene [SEP] A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that EN", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 17616, 1021, 3, 43, 14051, 8033, 13183, 6334, 1024, 5873, 2912, 10533, 2154, 1977, 1925, 7940, 7829, 2014, 8151, 6362, 1990, 1920, 2758, 2960, 18, 4725, 1988, 2066, 3]}]}
{"query": {"id": "q_764", "content": "retinal vein occlusion [SEP] OBJECTIVE: To report a case of central retinal vein occlusion associated with clomiphene citrate (CC). DESIGN: Case study. SE", "tokenized_content": [2, 6943, 7920, 10543, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 4101, 6943, 7920, 10543, 2458, 1956, 12596, 7395, 17616, 1021, 11599, 12, 4928, 13, 18, 3036, 30, 3087, 2161, 3]}, "items": [{"id": "p_764", "content": "Retinal Vein Occlusion [SEP] Blockage of the RETINAL VEIN. Those at high risk for this condition include patients with HYPERTENSION; DIABETES MELLITUS; ATHER", "score": 1, "type": null, "tokenized_content": [2, 6943, 7920, 10543, 3, 23615, 1927, 1920, 6943, 7920, 18, 2690, 2019, 2149, 2565, 1958, 2052, 2625, 3951, 2132, 1956, 5579, 31, 4032, 9695, 31, 7274, 3]}]}
{"query": {"id": "q_765", "content": "clomiphene citrate [SEP] report a case of central retinal vein occlusion associated with clomiphene citrate (CC). DESIGN: Case study. SETTING: Ophthalmology clinic of an a", "tokenized_content": [2, 12596, 7395, 17616, 1021, 11599, 3, 3809, 43, 3087, 1927, 4101, 6943, 7920, 10543, 2458, 1956, 12596, 7395, 17616, 1021, 11599, 12, 4928, 13, 18, 3036, 30, 3087, 2161, 18, 3]}, "items": [{"id": "p_765", "content": "Clomiphene [SEP] A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that EN", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 17616, 1021, 3, 43, 14051, 8033, 13183, 6334, 1024, 5873, 2912, 10533, 2154, 1977, 1925, 7940, 7829, 2014, 8151, 6362, 1990, 1920, 2758, 2960, 18, 4725, 1988, 2066, 3]}]}
{"query": {"id": "q_766", "content": "CC [SEP] tral retinal vein occlusion associated with clomiphene citrate (CC). DESIGN: Case study. SETTING: Ophthalmology clinic of an acade", "tokenized_content": [2, 4928, 3, 3390, 1024, 6943, 7920, 10543, 2458, 1956, 12596, 7395, 17616, 1021, 11599, 12, 4928, 13, 18, 3036, 30, 3087, 2161, 18, 4308, 30, 27063, 6248, 1927, 1925, 6732, 3]}, "items": [{"id": "p_766", "content": "Clomiphene [SEP] A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that EN", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 17616, 1021, 3, 43, 14051, 8033, 13183, 6334, 1024, 5873, 2912, 10533, 2154, 1977, 1925, 7940, 7829, 2014, 8151, 6362, 1990, 1920, 2758, 2960, 18, 4725, 1988, 2066, 3]}]}
{"query": {"id": "q_767", "content": "infertility [SEP] mic hospital. PATIENT(S): A 36-year-old woman referred from the infertility clinic for blurred vision. INTERVENTION(S): Ophthalmic examinat", "tokenized_content": [2, 15446, 3, 2206, 3461, 18, 2774, 12, 61, 13, 30, 43, 3480, 17, 2476, 17, 4156, 10440, 6656, 2037, 1920, 15446, 6248, 1958, 2266, 19294, 9266, 18, 3280, 12, 61, 3]}, "items": [{"id": "p_767", "content": "Infertility, Female [SEP] Diminished or absent ability of a female to achieve conception.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15446, 16, 4232, 3, 9597, 2014, 7685, 3682, 1927, 43, 4232, 1942, 6230, 13413, 18, 3]}]}
{"query": {"id": "q_768", "content": "blurred vision [SEP] ): A 36-year-old woman referred from the infertility clinic for blurred vision. INTERVENTION(S): Ophthalmic examination after CC therapy. MAIN", "tokenized_content": [2, 2266, 19294, 9266, 3, 13, 30, 43, 3480, 17, 2476, 17, 4156, 10440, 6656, 2037, 1920, 15446, 6248, 1958, 2266, 19294, 9266, 18, 3280, 12, 61, 13, 30, 21421, 4981, 3]}, "items": [{"id": "p_768", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_769", "content": "thromboembolic [SEP] on after eight courses of CC. A search of the literature on the thromboembolic complications of CC does not include this severe ophthalmic com", "tokenized_content": [2, 25580, 3, 1990, 2256, 5066, 12726, 1927, 4928, 18, 43, 4603, 1927, 1920, 4431, 1990, 1920, 25580, 5021, 1927, 4928, 3731, 2084, 3951, 2052, 4010, 21421, 2008, 3]}, "items": [{"id": "p_769", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_770", "content": "visual disturbance [SEP]  not include this severe ophthalmic complication, although mild visual disturbance after CC intake is not uncommon. CONCLUSION(S): This is the fir", "tokenized_content": [2, 3737, 12732, 3, 2084, 3951, 2052, 4010, 21421, 9388, 16, 2876, 5809, 3737, 12732, 2256, 4928, 5240, 1977, 2084, 14403, 18, 4180, 12, 61, 13, 30, 2052, 1977, 1920, 2527, 3]}, "items": [{"id": "p_770", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_771", "content": "Nicotine [SEP] Nicotine-induced nystagmus correlates with midpontine activation.", "tokenized_content": [2, 9303, 3, 9303, 17, 2719, 26133, 11431, 1957, 8706, 1956, 3953, 21851, 4425, 2936, 18, 3]}, "items": [{"id": "p_771", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_772", "content": "nystagmus [SEP] Nicotine-induced nystagmus correlates with midpontine activation.", "tokenized_content": [2, 26133, 11431, 1957, 3, 9303, 17, 2719, 26133, 11431, 1957, 8706, 1956, 3953, 21851, 4425, 2936, 18, 3]}, "items": [{"id": "p_772", "content": "Nystagmus, Pathologic [SEP] Involuntary movements of the eye that are divided into two types, jerk and pendular. Jerk nystagmus has a slow phase in one dire", "score": 1, "type": null, "tokenized_content": [2, 26133, 11431, 1957, 16, 11896, 3, 28493, 8264, 1927, 1920, 5723, 1988, 2032, 5831, 2460, 2288, 3584, 16, 26482, 1040, 1930, 26127, 2168, 18, 26482, 1040, 26133, 11431, 1957, 2258, 43, 5470, 3193, 1922, 2340, 2751, 3]}]}
{"query": {"id": "q_773", "content": "nicotine [SEP] The pathomechanism of nicotine-induced nystagmus (NIN) is unknown. The aim of this study was t", "tokenized_content": [2, 9303, 3, 1920, 2450, 2225, 25588, 11110, 1035, 1927, 9303, 17, 2719, 26133, 11431, 1957, 12, 12117, 13, 1977, 5435, 18, 1920, 3774, 1927, 2052, 2161, 1982, 62, 3]}, "items": [{"id": "p_773", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_774", "content": "nystagmus [SEP] The pathomechanism of nicotine-induced nystagmus (NIN) is unknown. The aim of this study was to delineate brain ", "tokenized_content": [2, 26133, 11431, 1957, 3, 1920, 2450, 2225, 25588, 11110, 1035, 1927, 9303, 17, 2719, 26133, 11431, 1957, 12, 12117, 13, 1977, 5435, 18, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 3]}, "items": [{"id": "p_774", "content": "Nystagmus, Pathologic [SEP] Involuntary movements of the eye that are divided into two types, jerk and pendular. Jerk nystagmus has a slow phase in one dire", "score": 1, "type": null, "tokenized_content": [2, 26133, 11431, 1957, 16, 11896, 3, 28493, 8264, 1927, 1920, 5723, 1988, 2032, 5831, 2460, 2288, 3584, 16, 26482, 1040, 1930, 26127, 2168, 18, 26482, 1040, 26133, 11431, 1957, 2258, 43, 5470, 3193, 1922, 2340, 2751, 3]}]}
{"query": {"id": "q_775", "content": "NIN [SEP] The pathomechanism of nicotine-induced nystagmus (NIN) is unknown. The aim of this study was to delineate brain struc", "tokenized_content": [2, 12117, 3, 1920, 2450, 2225, 25588, 11110, 1035, 1927, 9303, 17, 2719, 26133, 11431, 1957, 12, 12117, 13, 1977, 5435, 18, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 19222, 3068, 3]}, "items": [{"id": "p_775", "content": "Nystagmus, Pathologic [SEP] Involuntary movements of the eye that are divided into two types, jerk and pendular. Jerk nystagmus has a slow phase in one dire", "score": 1, "type": null, "tokenized_content": [2, 26133, 11431, 1957, 16, 11896, 3, 28493, 8264, 1927, 1920, 5723, 1988, 2032, 5831, 2460, 2288, 3584, 16, 26482, 1040, 1930, 26127, 2168, 18, 26482, 1040, 26133, 11431, 1957, 2258, 43, 5470, 3193, 1922, 2340, 2751, 3]}]}
{"query": {"id": "q_776", "content": "oxygen [SEP] e registered using video-oculography. NIN correlated with blood oxygen level-dependent (BOLD) activity levels in a midpontine site in ", "tokenized_content": [2, 4612, 3, 47, 10012, 2193, 8650, 17, 25669, 3796, 18, 12117, 4374, 1956, 2877, 4612, 2237, 17, 3100, 12, 9884, 13, 2455, 2428, 1922, 43, 3953, 21851, 4425, 3200, 1922, 3]}, "items": [{"id": "p_776", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_777", "content": "verapamil [SEP] Protective effect of verapamil on gastric hemorrhagic ulcers in severe atherosclerotic rats.", "tokenized_content": [2, 23300, 3, 6337, 2495, 1927, 23300, 1990, 6319, 16052, 16225, 1922, 4010, 13450, 3615, 18, 3]}, "items": [{"id": "p_777", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_778", "content": "gastric hemorrhagic [SEP] Protective effect of verapamil on gastric hemorrhagic ulcers in severe atherosclerotic rats.", "tokenized_content": [2, 6319, 16052, 3, 6337, 2495, 1927, 23300, 1990, 6319, 16052, 16225, 1922, 4010, 13450, 3615, 18, 3]}, "items": [{"id": "p_778", "content": "Gastrointestinal Hemorrhage [SEP] Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 10489, 3, 7633, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_779", "content": "ulcers [SEP] Protective effect of verapamil on gastric hemorrhagic ulcers in severe atherosclerotic rats.", "tokenized_content": [2, 16225, 3, 6337, 2495, 1927, 23300, 1990, 6319, 16052, 16225, 1922, 4010, 13450, 3615, 18, 3]}, "items": [{"id": "p_779", "content": "Ulcer [SEP] A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10096, 3, 43, 5709, 1990, 1920, 3154, 1927, 1920, 4407, 2014, 43, 27103, 3154, 16, 4152, 2007, 1920, 24876, 2491, 1941, 1927, 3769, 14275, 2960, 18, 3]}]}
{"query": {"id": "q_780", "content": "atherosclerotic [SEP] ive effect of verapamil on gastric hemorrhagic ulcers in severe atherosclerotic rats.", "tokenized_content": [2, 13450, 3, 4370, 1021, 2495, 1927, 23300, 1990, 6319, 16052, 16225, 1922, 4010, 13450, 3615, 18, 3]}, "items": [{"id": "p_780", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_781", "content": "gastric hemorrhage [SEP] Studies concerning with pathogenesis of gastric hemorrhage and mucosal ulceration produced in atherosclerotic rats are lac", "tokenized_content": [2, 6319, 10489, 3, 2351, 8679, 1956, 6559, 1927, 6319, 10489, 1930, 9565, 23509, 4152, 1922, 13450, 3615, 2032, 7511, 3]}, "items": [{"id": "p_781", "content": "Gastrointestinal Hemorrhage [SEP] Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 10489, 3, 7633, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_782", "content": "atherosclerotic [SEP] enesis of gastric hemorrhage and mucosal ulceration produced in atherosclerotic rats are lacking. The aim of this study is to examine the role ", "tokenized_content": [2, 13450, 3, 2066, 2600, 1927, 6319, 10489, 1930, 9565, 23509, 4152, 1922, 13450, 3615, 2032, 7046, 18, 1920, 3774, 1927, 2052, 2161, 1977, 1942, 5020, 1920, 2770, 3]}, "items": [{"id": "p_782", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_783", "content": "histamine [SEP] s to examine the role of gastric acid back-diffusion, mast cell histamine release, lipid peroxide (LPO) generation and mucosal microvascu", "tokenized_content": [2, 14622, 3, 61, 1942, 5020, 1920, 2770, 1927, 6319, 2687, 3231, 17, 6601, 16, 9731, 2024, 14622, 4012, 16, 4486, 12316, 12, 8182, 1037, 13, 4841, 1930, 9565, 14264, 2976, 3]}, "items": [{"id": "p_783", "content": "Histamine [SEP] An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of br", "score": 1, "type": null, "tokenized_content": [2, 14622, 3, 1925, 13610, 3595, 2007, 8145, 22429, 1943, 1927, 13873, 18, 2176, 1977, 43, 9974, 24252, 1927, 6319, 5512, 16, 43, 15595, 2684, 1927, 2387, 3]}]}
{"query": {"id": "q_784", "content": "ulcer [SEP]  concerning with pathogenesis of gastric hemorrhage and mucosal ulceration produced in atherosclerotic rats are lacking. The aim of t", "tokenized_content": [2, 10096, 3, 8679, 1956, 6559, 1927, 6319, 10489, 1930, 9565, 23509, 4152, 1922, 13450, 3615, 2032, 7046, 18, 1920, 3774, 1927, 62, 3]}, "items": [{"id": "p_784", "content": "Ulcer [SEP] A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10096, 3, 43, 5709, 1990, 1920, 3154, 1927, 1920, 4407, 2014, 43, 27103, 3154, 16, 4152, 2007, 1920, 24876, 2491, 1941, 1927, 3769, 14275, 2960, 18, 3]}]}
{"query": {"id": "q_785", "content": "atherosclerosis [SEP] ability in modulating gastric hemorrhage and ulcer in rats with atherosclerosis induced by coadministration of vitamin D2 and cholesterol. Addi", "tokenized_content": [2, 9824, 3, 3682, 1922, 10871, 6319, 10489, 1930, 10096, 1922, 3615, 1956, 9824, 2719, 2007, 29818, 8547, 3934, 1927, 6111, 8631, 1930, 5463, 18, 3019, 1033, 3]}, "items": [{"id": "p_785", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_786", "content": "vitamin D2 [SEP] cer in rats with atherosclerosis induced by coadministration of vitamin D2 and cholesterol. Additionally, the protective effect of verapam", "tokenized_content": [2, 6111, 8631, 3, 6580, 1922, 3615, 1956, 9824, 2719, 2007, 29818, 8547, 3934, 1927, 6111, 8631, 1930, 5463, 18, 4950, 16, 1920, 6337, 2495, 1927, 3566, 29398, 1035, 3]}, "items": [{"id": "p_786", "content": "Ergocalciferols [SEP] Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a d", "score": 1, "type": null, "tokenized_content": [2, 11949, 5000, 3349, 2070, 3706, 3, 8383, 1927, 11949, 23030, 5333, 2007, 17077, 16789, 18951, 1927, 1920, 19224, 17, 24523, 5403, 18, 2611, 2129, 2037, 17177, 8515, 3236, 1945, 1922, 4537, 43, 46, 3]}]}
{"query": {"id": "q_787", "content": "cholesterol [SEP] h atherosclerosis induced by coadministration of vitamin D2 and cholesterol. Additionally, the protective effect of verapamil on this ulcer", "tokenized_content": [2, 5463, 3, 50, 9824, 2719, 2007, 29818, 8547, 3934, 1927, 6111, 8631, 1930, 5463, 18, 4950, 16, 1920, 6337, 2495, 1927, 23300, 1990, 2052, 10096, 3]}, "items": [{"id": "p_787", "content": "Cholesterol [SEP] The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fat", "score": 1, "type": null, "tokenized_content": [2, 5463, 3, 1920, 7944, 20408, 1927, 2136, 2580, 3555, 16, 6533, 1922, 3362, 3878, 16, 4369, 1920, 3068, 1930, 6071, 6670, 16, 1930, 1922, 4027, 3777, 3]}]}
{"query": {"id": "q_788", "content": "verapamil [SEP] amin D2 and cholesterol. Additionally, the protective effect of verapamil on this ulcer model was evaluated. Male Wistar rats were challe", "tokenized_content": [2, 23300, 3, 8584, 8631, 1930, 5463, 18, 4950, 16, 1920, 6337, 2495, 1927, 23300, 1990, 2052, 10096, 2322, 1982, 3747, 18, 4005, 15668, 3615, 1985, 4123, 1021, 3]}, "items": [{"id": "p_788", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_789", "content": "luminal [SEP] eneration, histamine concentration, microvascular permeability, luminal hemoglobin content and ulcer areas were determined. Elevated at", "tokenized_content": [2, 11776, 3, 2066, 5026, 16, 14622, 3110, 16, 13943, 8828, 16, 11776, 9652, 3919, 1930, 10096, 3957, 1985, 3180, 18, 4664, 2019, 3]}, "items": [{"id": "p_789", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_790", "content": "calcium [SEP]  determined. Elevated atherosclerotic parameters, such as serum calcium, total cholesterol and low-density lipoprotein concentration we", "tokenized_content": [2, 5016, 3, 3180, 18, 4664, 13450, 3673, 16, 2427, 1966, 3256, 5016, 16, 2698, 5463, 1930, 2330, 17, 3824, 9694, 3110, 2038, 3]}, "items": [{"id": "p_790", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_791", "content": "ulcers [SEP] entration were obtained in atherosclerotic rats. Severe gastric ulcers accompanied with increased ulcerogenic factors, including gastr", "tokenized_content": [2, 16225, 3, 5695, 1943, 1985, 2926, 1922, 13450, 3615, 18, 4010, 6319, 16225, 7936, 1956, 2502, 10096, 3880, 2790, 16, 2710, 14860, 3]}, "items": [{"id": "p_791", "content": "Ulcer [SEP] A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10096, 3, 43, 5709, 1990, 1920, 3154, 1927, 1920, 4407, 2014, 43, 27103, 3154, 16, 4152, 2007, 1920, 24876, 2491, 1941, 1927, 3769, 14275, 2960, 18, 3]}]}
{"query": {"id": "q_792", "content": "hemorrhagic [SEP] hage and to ulcer was found in those atherosclerotic rats. This hemorrhagic ulcer and various ulcerogenic parameters were dose-dependently ", "tokenized_content": [2, 16052, 3, 27710, 1021, 1930, 1942, 10096, 1982, 2435, 1922, 2690, 13450, 3615, 18, 2052, 16052, 10096, 1930, 3425, 10096, 3880, 3673, 1985, 3253, 17, 19898, 3]}, "items": [{"id": "p_792", "content": "Gastrointestinal Hemorrhage [SEP] Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 10489, 3, 7633, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_793", "content": "Atherosclerosis [SEP] e dose-dependently ameliorated by daily intragastric verapamil. Atherosclerosis could produce gastric hemorrhagic ulcer via aggravation of gast", "tokenized_content": [2, 9824, 3, 47, 3253, 17, 19898, 22085, 2007, 4692, 27911, 18318, 23300, 18, 9824, 2578, 5074, 6319, 16052, 10096, 3454, 18206, 1943, 1927, 6215, 3]}, "items": [{"id": "p_793", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_794", "content": "gastric hemorrhagic [SEP]  by daily intragastric verapamil. Atherosclerosis could produce gastric hemorrhagic ulcer via aggravation of gastric acid back-diffusion, LPO gener", "tokenized_content": [2, 6319, 16052, 3, 2007, 4692, 27911, 18318, 23300, 18, 9824, 2578, 5074, 6319, 16052, 10096, 3454, 18206, 1943, 1927, 6319, 2687, 3231, 17, 6601, 16, 8182, 1037, 2467, 3]}, "items": [{"id": "p_794", "content": "Gastrointestinal Hemorrhage [SEP] Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 10489, 3, 7633, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_795", "content": "Adriamycin [SEP] Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role ", "tokenized_content": [2, 25622, 7898, 3, 25622, 7898, 17, 2719, 15319, 18357, 3539, 5705, 43, 8070, 2770, 3]}, "items": [{"id": "p_795", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_796", "content": "death [SEP] Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure.", "tokenized_content": [2, 3539, 3, 25622, 7898, 17, 2719, 15319, 18357, 3539, 5705, 43, 8070, 2770, 1922, 43, 3067, 2322, 1927, 4003, 4574, 18, 3]}, "items": [{"id": "p_796", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_797", "content": "heart failure [SEP] c cardiomyocyte death plays a pathogenic role in a rat model of heart failure.", "tokenized_content": [2, 4003, 4574, 3, 45, 18357, 3539, 5705, 43, 8070, 2770, 1922, 43, 3067, 2322, 1927, 4003, 4574, 18, 3]}, "items": [{"id": "p_797", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_798", "content": "heart failure [SEP] BACKGROUND: The mechanisms underlying heart failure induced by adriamycin are very complicated and still unclear. T", "tokenized_content": [2, 4003, 4574, 3, 3872, 30, 1920, 3531, 5030, 4003, 4574, 2719, 2007, 25622, 7898, 2032, 3345, 9881, 1930, 3974, 6390, 18, 62, 3]}, "items": [{"id": "p_798", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_799", "content": "adriamycin [SEP] BACKGROUND: The mechanisms underlying heart failure induced by adriamycin are very complicated and still unclear. The aim of this study w", "tokenized_content": [2, 25622, 7898, 3, 3872, 30, 1920, 3531, 5030, 4003, 4574, 2719, 2007, 25622, 7898, 2032, 3345, 9881, 1930, 3974, 6390, 18, 1920, 3774, 1927, 2052, 2161, 65, 3]}, "items": [{"id": "p_799", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_800", "content": "3-methyladenine [SEP]  develop a novel treatment strategy for heart failure. METHODS: 3-methyladenine (3MA), a specific inhibitor on autophagy was used in a heart fa", "tokenized_content": [2, 23, 17, 4963, 10185, 2053, 3, 2392, 43, 4008, 2311, 4884, 1958, 4003, 4574, 18, 2860, 30, 23, 17, 4963, 10185, 2053, 12, 23445, 1019, 13, 16, 43, 2487, 4106, 3]}, "items": [{"id": "p_800", "content": "3-methyladenine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 4963, 10185, 2053, 3, 3]}]}
{"query": {"id": "q_801", "content": "3MA [SEP] treatment strategy for heart failure. METHODS: 3-methyladenine (3MA), a specific inhibitor on autophagy was used in a heart failure", "tokenized_content": [2, 23445, 1019, 3, 2311, 4884, 1958, 4003, 4574, 18, 2860, 30, 23, 17, 4963, 10185, 2053, 12, 23445, 1019, 13, 16, 43, 2487, 4106, 1990, 6661, 1982, 2251, 1922, 43, 3]}, "items": [{"id": "p_801", "content": "3-methyladenine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 4963, 10185, 2053, 3, 3]}]}
{"query": {"id": "q_802", "content": "K [SEP] BACKGROUND: The mechanisms underlying heart failure induced by adria", "tokenized_content": [2, 53, 3, 3872, 30, 1920, 3531, 5030, 4003, 4574, 2719, 2007, 25622, 1019, 3]}, "items": [{"id": "p_802", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_803", "content": "death [SEP] on of autophagic vacuoles. CONCLUSION: Autophagic cardiomyocyte death plays an important role in the pathogenesis of heart failure in", "tokenized_content": [2, 3539, 3, 1990, 1927, 15319, 19129, 18, 4180, 30, 15319, 18357, 3539, 5705, 1925, 2715, 2770, 1922, 1920, 6559, 1927, 4003, 4574, 1922, 3]}, "items": [{"id": "p_803", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_804", "content": "Confusion [SEP] Confusion, a rather serious adverse drug reaction with valproic acid: a r", "tokenized_content": [2, 18272, 3, 18272, 16, 43, 4356, 7433, 5246, 2838, 3227, 1956, 23867, 1935, 2687, 30, 43, 60, 3]}, "items": [{"id": "p_804", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_805", "content": "valproic acid [SEP] Confusion, a rather serious adverse drug reaction with valproic acid: a review of the French Pharmacovigilance database.", "tokenized_content": [2, 23867, 1935, 2687, 3, 18272, 16, 43, 4356, 7433, 5246, 2838, 3227, 1956, 23867, 1935, 2687, 30, 43, 3043, 1927, 1920, 12941, 4602, 25210, 6121, 17576, 1972, 5039, 18, 3]}, "items": [{"id": "p_805", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_806", "content": "Confusion [SEP] INTRODUCTION: Confusion is an adverse drug reaction frequently observed with valproic a", "tokenized_content": [2, 18272, 3, 6935, 30, 18272, 1977, 1925, 5246, 2838, 3227, 5467, 2528, 1956, 23867, 1935, 43, 3]}, "items": [{"id": "p_806", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_807", "content": "valproic acid [SEP]  Confusion is an adverse drug reaction frequently observed with valproic acid. Some case reports are published in the literature but no syste", "tokenized_content": [2, 23867, 1935, 2687, 3, 18272, 1977, 1925, 5246, 2838, 3227, 5467, 2528, 1956, 23867, 1935, 2687, 18, 2673, 3087, 4710, 2032, 4586, 1922, 1920, 4431, 2308, 2239, 8055, 1021, 3]}, "items": [{"id": "p_807", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_808", "content": "confusion [SEP] the French Pharmacovigilance database, we selected the cases of confusion reported since 1985 with valproic acid. RESULTS: 272 cases of c", "tokenized_content": [2, 18272, 3, 1920, 12941, 4602, 25210, 6121, 17576, 1972, 5039, 16, 2038, 3790, 1920, 2919, 1927, 18272, 2568, 3328, 11917, 1956, 23867, 1935, 2687, 18, 2274, 30, 22785, 2919, 1927, 3]}, "items": [{"id": "p_808", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_809", "content": "memory deficits [SEP] Learning and memory deficits in ecstasy users and their neural correlates during a face-lear", "tokenized_content": [2, 4525, 7961, 3, 4809, 1930, 4525, 7961, 1922, 12587, 3857, 18801, 6603, 1930, 2310, 5181, 8706, 2409, 43, 6171, 17, 4237, 3]}, "items": [{"id": "p_809", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_810", "content": "ecstasy [SEP] Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task.", "tokenized_content": [2, 12587, 3857, 18801, 3, 4809, 1930, 4525, 7961, 1922, 12587, 3857, 18801, 6603, 1930, 2310, 5181, 8706, 2409, 43, 6171, 17, 4809, 3909, 18, 3]}, "items": [{"id": "p_810", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_811", "content": "ecstasy [SEP] It has been consistently shown that ecstasy users display impairments in learning and memory performance. I", "tokenized_content": [2, 12587, 3857, 18801, 3, 2176, 2258, 2252, 7522, 2522, 1988, 12587, 3857, 18801, 6603, 4434, 12454, 1922, 4809, 1930, 4525, 3604, 18, 51, 3]}, "items": [{"id": "p_811", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_812", "content": "impairments in learning [SEP] It has been consistently shown that ecstasy users display impairments in learning and memory performance. In addition, working memory processing ", "tokenized_content": [2, 12454, 1922, 4809, 3, 2176, 2258, 2252, 7522, 2522, 1988, 12587, 3857, 18801, 6603, 4434, 12454, 1922, 4809, 1930, 4525, 3604, 18, 1922, 2459, 16, 5905, 4525, 4587, 3]}, "items": [{"id": "p_812", "content": "Learning Disorders [SEP] Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to ", "score": 1, "type": null, "tokenized_content": [2, 4809, 4414, 3, 2961, 4378, 2007, 43, 2228, 12156, 2192, 1925, 2725, 11, 61, 6523, 2237, 1927, 12744, 1930, 2310, 3682, 1942, 3]}]}
{"query": {"id": "q_813", "content": "cannabis [SEP] 0 controls. To address the potential confounding effects of the cannabis use of the ecstasy using group, a second analysis included 14 p", "tokenized_content": [2, 14664, 3, 20, 3562, 18, 1942, 4640, 1920, 2889, 10451, 2564, 1927, 1920, 14664, 2485, 1927, 1920, 12587, 3857, 18801, 2193, 2210, 16, 43, 2812, 2333, 3063, 2607, 58, 3]}, "items": [{"id": "p_813", "content": "Cannabis [SEP] The plant genus in the Cannabaceae plant family, Urticales order, Hamamelidae subclass. The flowering tops are called many slang", "score": 1, "type": null, "tokenized_content": [2, 14664, 3, 1920, 4496, 9487, 1922, 1920, 11301, 9914, 4496, 3416, 16, 27986, 3955, 3238, 16, 8616, 15481, 10828, 17625, 18, 1920, 15346, 3700, 1036, 2032, 6043, 3086, 18548, 2029, 3]}]}
{"query": {"id": "q_814", "content": "Deficits in learning [SEP]  users (Nestor, L., Roberts, G., Garavan, H., Hester, R., 2008. Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hy", "tokenized_content": [2, 7961, 1922, 4809, 3, 6603, 12, 15681, 1924, 16, 54, 18, 16, 20714, 16, 49, 18, 16, 13139, 15777, 1022, 16, 50, 18, 16, 10688, 1967, 16, 60, 18, 16, 3]}, "items": [{"id": "p_814", "content": "Learning Disorders [SEP] Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to ", "score": 1, "type": null, "tokenized_content": [2, 4809, 4414, 3, 2961, 4378, 2007, 43, 2228, 12156, 2192, 1925, 2725, 11, 61, 6523, 2237, 1927, 12744, 1930, 2310, 3682, 1942, 3]}]}
{"query": {"id": "q_815", "content": "hyperactivity [SEP] ter, R., 2008. Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users. Neuroimage 4", "tokenized_content": [2, 15534, 3, 6005, 16, 60, 18, 16, 3767, 18, 7961, 1922, 4809, 1930, 4525, 30, 8202, 29385, 1923, 15534, 1930, 27047, 4879, 7446, 2046, 14395, 5454, 1922, 14664, 6603, 18, 3]}, "items": [{"id": "p_815", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_816", "content": "Ecstasy [SEP] ical hypoactivity in cannabis users. Neuroimage 40, 1328-1339). Ecstasy users performed significantly worse in learning and memory comp", "tokenized_content": [2, 12587, 3857, 18801, 3, 14784, 1024, 14395, 5454, 1922, 14664, 6603, 18, 25127, 3040, 16, 11824, 1025, 17, 12147, 1026, 13, 18, 12587, 3857, 18801, 6603, 2593, 2567, 9190, 1922, 3]}, "items": [{"id": "p_816", "content": "N-Methyl-3,4-methylenedioxyamphetamine [SEP] An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting cha", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 17, 23, 16, 24, 17, 17947, 7408, 7221, 18996, 3, 1925, 56, 17, 11798, 19057, 5729, 18, 2176, 1977, 43, 5673, 7764, 1007, 2838, 5947, 1966, 43, 20958, 3522, 2432, 1930, 5092, 4961, 16, 2815, 17, 11671, 13297, 3]}]}
{"query": {"id": "q_817", "content": "neurotoxic [SEP] he vulnerability of isocortical and allocortical regions to the neurotoxic effects of ecstasy.", "tokenized_content": [2, 20919, 3, 2234, 13026, 1927, 24179, 14694, 1930, 21653, 14694, 3451, 1942, 1920, 20919, 2564, 1927, 12587, 3857, 18801, 18, 3]}, "items": [{"id": "p_817", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_818", "content": "argatroban [SEP] Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of hep", "tokenized_content": [2, 4582, 12078, 26205, 1022, 3, 7171, 8644, 1927, 3582, 4582, 12078, 26205, 1022, 1922, 43, 4435, 5192, 2774, 1956, 43, 9407, 4403, 1927, 3357, 3]}, "items": [{"id": "p_818", "content": "argatroban [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4582, 12078, 26205, 1022, 3, 3]}]}
{"query": {"id": "q_819", "content": "heparin [SEP] ban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis.", "tokenized_content": [2, 9962, 3, 15114, 1922, 43, 4435, 5192, 2774, 1956, 43, 9407, 4403, 1927, 9962, 17, 2719, 17100, 1956, 11354, 18, 3]}, "items": [{"id": "p_819", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_820", "content": "thrombocytopenia [SEP]  transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis.", "tokenized_content": [2, 17100, 3, 5192, 2774, 1956, 43, 9407, 4403, 1927, 9962, 17, 2719, 17100, 1956, 11354, 18, 3]}, "items": [{"id": "p_820", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_821", "content": "thrombosis [SEP] th a suspected history of heparin-induced thrombocytopenia with thrombosis.", "tokenized_content": [2, 11354, 3, 1913, 43, 9407, 4403, 1927, 9962, 17, 2719, 17100, 1956, 11354, 18, 3]}, "items": [{"id": "p_821", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_822", "content": "heparin [SEP] native method of anticoagulation for patients with a history of heparin-induced thrombocytopenia (HIT) or HIT with thrombosis (HITT) un", "tokenized_content": [2, 9962, 3, 6196, 2417, 1927, 18331, 1958, 2132, 1956, 43, 4403, 1927, 9962, 17, 2719, 17100, 12, 11314, 13, 2014, 11314, 1956, 11354, 12, 11314, 1031, 13, 2067, 3]}, "items": [{"id": "p_822", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_823", "content": "thrombocytopenia [SEP]  anticoagulation for patients with a history of heparin-induced thrombocytopenia (HIT) or HIT with thrombosis (HITT) undergoing cardiopulmonary ", "tokenized_content": [2, 17100, 3, 18331, 1958, 2132, 1956, 43, 4403, 1927, 9962, 17, 2719, 17100, 12, 11314, 13, 2014, 11314, 1956, 11354, 12, 11314, 1031, 13, 7258, 17749, 3]}, "items": [{"id": "p_823", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_824", "content": "HIT [SEP] or patients with a history of heparin-induced thrombocytopenia (HIT) or HIT with thrombosis (HITT) undergoing cardiopulmonary bypas", "tokenized_content": [2, 11314, 3, 2014, 2132, 1956, 43, 4403, 1927, 9962, 17, 2719, 17100, 12, 11314, 13, 2014, 11314, 1956, 11354, 12, 11314, 1031, 13, 7258, 17749, 2007, 4302, 1036, 3]}, "items": [{"id": "p_824", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_825", "content": "thrombosis [SEP] a history of heparin-induced thrombocytopenia (HIT) or HIT with thrombosis (HITT) undergoing cardiopulmonary bypass (CPB). In the followin", "tokenized_content": [2, 11354, 3, 43, 4403, 1927, 9962, 17, 2719, 17100, 12, 11314, 13, 2014, 11314, 1956, 11354, 12, 11314, 1031, 13, 7258, 17749, 10344, 12, 21060, 13, 18, 1922, 1920, 2396, 3]}, "items": [{"id": "p_825", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_826", "content": "critically ill [SEP] opulmonary bypass (CPB). In the following report, a 65-year-old critically ill patient with a suspected history of HITT was administered argat", "tokenized_content": [2, 9790, 3652, 3, 2494, 13897, 10344, 12, 21060, 13, 18, 1922, 1920, 2894, 3809, 16, 43, 4459, 17, 2476, 17, 4156, 9790, 3652, 2774, 1956, 43, 9407, 4403, 1927, 11314, 3]}, "items": [{"id": "p_826", "content": "Critical Illness [SEP] A disease or state in which death is possible or imminent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4140, 6455, 3, 43, 2573, 2014, 3360, 1922, 2154, 3539, 1977, 3216, 2014, 4960, 2053, 4905, 18, 3]}]}
{"query": {"id": "q_827", "content": "argatroban [SEP] y ill patient with a suspected history of HITT was administered argatroban for anticoagulation on bypass during heart transplantation. The", "tokenized_content": [2, 4582, 12078, 26205, 1022, 3, 67, 3652, 2774, 1956, 43, 9407, 4403, 1927, 11314, 1031, 1982, 5254, 4582, 12078, 26205, 1022, 1958, 18331, 1990, 10344, 2409, 4003, 6530, 18, 1920, 3]}, "items": [{"id": "p_827", "content": "argatroban [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4582, 12078, 26205, 1022, 3, 3]}]}
{"query": {"id": "q_828", "content": "postoperative bleeding [SEP] doses of recombinant Factor VIIa) for severe intraoperative and postoperative bleeding. STUDY DESIGN AND METHODS: Plasma samples from before and after", "tokenized_content": [2, 5924, 7633, 3, 5312, 1927, 5752, 2991, 16852, 1019, 13, 1958, 4010, 12122, 1930, 5924, 7633, 18, 2161, 3036, 1930, 2860, 30, 3582, 2785, 2037, 3119, 1930, 2256, 3]}, "items": [{"id": "p_828", "content": "Postoperative Hemorrhage [SEP] Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5924, 10489, 3, 10489, 2894, 2967, 4548, 4360, 18, 2176, 2278, 1998, 8426, 2014, 7083, 1930, 1977, 2084, 6715, 1942, 1920, 4548, 6376, 18, 3]}]}
{"query": {"id": "q_829", "content": "hepatic impairment [SEP] ed elimination t(1/2) is 39-51 minutes [< or = 181 minutes with hepatic impairment]). CONCLUSIONS: Correlation of plasma argatroban concentration ", "tokenized_content": [2, 6095, 6159, 3, 3347, 9570, 62, 12, 21, 19, 22, 13, 1977, 3886, 17, 4892, 4814, 37, 32, 2014, 33, 16997, 4814, 1956, 6095, 6159, 39, 13, 18, 4355, 30, 3]}, "items": [{"id": "p_829", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_830", "content": "coagulopathy [SEP] lasma argatroban may have contributed to the patient's extended coagulopathy. Because DTIs do not have reversal agents, surgical teams and t", "tokenized_content": [2, 19804, 6522, 3, 4800, 3368, 4582, 12078, 26205, 1022, 2278, 2162, 6505, 1942, 1920, 2774, 11, 61, 6091, 19804, 6522, 18, 2882, 17997, 1036, 2608, 2084, 2162, 12393, 4820, 16, 3]}, "items": [{"id": "p_830", "content": "Blood Coagulation Disorders [SEP] Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of facto", "score": 1, "type": null, "tokenized_content": [2, 2877, 12441, 4414, 3, 16052, 1930, 21039, 4414, 1988, 4704, 1966, 43, 7749, 1927, 6754, 1922, 2877, 12441, 2810, 1942, 43, 5386, 1927, 2371, 1037, 3]}]}
{"query": {"id": "q_831", "content": "Antituberculosis [SEP] Antituberculosis therapy-induced acute liver failure: magnitude, profile, progno", "tokenized_content": [2, 10310, 29603, 8071, 3, 10310, 29603, 8071, 3181, 17, 2719, 3939, 3568, 4574, 30, 6453, 16, 5174, 16, 4799, 1037, 3]}, "items": [{"id": "p_831", "content": "Antitubercular Agents [SEP] Drugs used in the treatment of tuberculosis. They are divided into two main classes: \"first-line\" agents, those with the greates", "score": 1, "type": null, "tokenized_content": [2, 10310, 29603, 2168, 4820, 3, 4195, 2251, 1922, 1920, 2311, 1927, 8449, 18, 2611, 2032, 5831, 2460, 2288, 2730, 7190, 30, 6, 2561, 17, 2823, 6, 4820, 16, 2690, 1956, 1920, 4733, 1918, 3]}]}
{"query": {"id": "q_832", "content": "acute liver failure [SEP] Antituberculosis therapy-induced acute liver failure: magnitude, profile, prognosis, and predictors of outcome.", "tokenized_content": [2, 3939, 3568, 4574, 3, 10310, 29603, 8071, 3181, 17, 2719, 3939, 3568, 4574, 30, 6453, 16, 5174, 16, 6573, 16, 1930, 7450, 1927, 3924, 18, 3]}, "items": [{"id": "p_832", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_833", "content": "Antituberculosis [SEP] Antituberculosis therapy (ATT)-associated acute liver failure (ATT-ALF) is the c", "tokenized_content": [2, 10310, 29603, 8071, 3, 10310, 29603, 8071, 3181, 12, 3099, 13, 17, 2458, 3939, 3568, 4574, 12, 3099, 17, 17913, 13, 1977, 1920, 45, 3]}, "items": [{"id": "p_833", "content": "Antitubercular Agents [SEP] Drugs used in the treatment of tuberculosis. They are divided into two main classes: \"first-line\" agents, those with the greates", "score": 1, "type": null, "tokenized_content": [2, 10310, 29603, 2168, 4820, 3, 4195, 2251, 1922, 1920, 2311, 1927, 8449, 18, 2611, 2032, 5831, 2460, 2288, 2730, 7190, 30, 6, 2561, 17, 2823, 6, 4820, 16, 2690, 1956, 1920, 4733, 1918, 3]}]}
{"query": {"id": "q_834", "content": "acute liver failure [SEP] Antituberculosis therapy (ATT)-associated acute liver failure (ATT-ALF) is the commonest drug-induced ALF in South Asia. Pros", "tokenized_content": [2, 3939, 3568, 4574, 3, 10310, 29603, 8071, 3181, 12, 3099, 13, 17, 2458, 3939, 3568, 4574, 12, 3099, 17, 17913, 13, 1977, 1920, 29200, 2838, 17, 2719, 17913, 1922, 6061, 3]}, "items": [{"id": "p_834", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_835", "content": "ALF [SEP] ituberculosis therapy (ATT)-associated acute liver failure (ATT-ALF) is the commonest drug-induced ALF in South Asia. Prospective s", "tokenized_content": [2, 17913, 3, 2176, 29603, 8071, 3181, 12, 3099, 13, 17, 2458, 3939, 3568, 4574, 12, 3099, 17, 17913, 13, 1977, 1920, 29200, 2838, 17, 2719, 17913, 1922, 6061, 11624, 18, 3]}, "items": [{"id": "p_835", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_836", "content": "hepatitis virus infection [SEP]  70 (5.7%) patients. Another 15 (1.2%) had ATT and simultaneous hepatitis virus infection. In 44 (62.8%) patients, ATT was prescribed empirically without", "tokenized_content": [2, 7977, 3413, 2909, 3, 3895, 12, 25, 18, 27, 9, 13, 2132, 18, 3741, 2461, 12, 21, 18, 22, 9, 13, 2430, 3099, 1930, 5710, 7977, 3413, 2909, 18, 1922, 3]}, "items": [{"id": "p_836", "content": "Hepatitis, Viral, Human [SEP] INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis wi", "score": 1, "type": null, "tokenized_content": [2, 7977, 16, 4324, 16, 2616, 3, 4531, 1927, 1920, 3568, 1922, 5209, 2810, 1942, 2909, 2007, 6241, 18, 2276, 2032, 2980, 2228, 3584, 1927, 2616, 4324, 7977, 11980, 3]}]}
{"query": {"id": "q_837", "content": "tuberculosis [SEP] Antituberculosis therapy (ATT)-associated acute liver failure (ATT-ALF) is the c", "tokenized_content": [2, 8449, 3, 10310, 29603, 8071, 3181, 12, 3099, 13, 17, 2458, 3939, 3568, 4574, 12, 3099, 17, 17913, 13, 1977, 1920, 45, 3]}, "items": [{"id": "p_837", "content": "Tuberculosis [SEP] Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8449, 3, 2967, 1927, 1920, 7465, 3902, 1927, 2323, 1930, 2303, 3555, 4189, 2007, 3038, 1927, 16389, 18, 3]}]}
{"query": {"id": "q_838", "content": "icterus [SEP] f them were women. Most had hyperacute presentation; the median icterus encephalopathy interval was 4.5 (0-30) days. The median duratio", "tokenized_content": [2, 18451, 25822, 3, 48, 3581, 1985, 3089, 18, 2501, 2430, 4194, 22832, 6544, 31, 1920, 4181, 18451, 25822, 19393, 4979, 1982, 24, 18, 25, 12, 20, 17, 2627, 13, 3000, 3]}, "items": [{"id": "p_838", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_839", "content": "encephalopathy [SEP] ere women. Most had hyperacute presentation; the median icterus encephalopathy interval was 4.5 (0-30) days. The median duration of ATT before", "tokenized_content": [2, 19393, 3, 22561, 3089, 18, 2501, 2430, 4194, 22832, 6544, 31, 1920, 4181, 18451, 25822, 19393, 4979, 1982, 24, 18, 25, 12, 20, 17, 2627, 13, 3000, 18, 1920, 4181, 3]}, "items": [{"id": "p_839", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_840", "content": "cerebral edema [SEP] s 30 (7-350) days. At presentation, advanced encephalopathy and cerebral edema were present in 51 (76%) and 29 (41.4%) patients, respectively.", "tokenized_content": [2, 6329, 10144, 3, 61, 2627, 12, 27, 17, 11936, 13, 3000, 18, 2019, 6544, 16, 5570, 19393, 1930, 6329, 10144, 1985, 2481, 1922, 4892, 12, 5439, 9, 13, 1930, 3230, 3]}, "items": [{"id": "p_840", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_841", "content": "Gastrointestinal bleed [SEP] were present in 51 (76%) and 29 (41.4%) patients, respectively. Gastrointestinal bleed, seizures, infection, and acute renal failure were documented i", "tokenized_content": [2, 8375, 6189, 1919, 3, 1985, 2481, 1922, 4892, 12, 5439, 9, 13, 1930, 3230, 12, 4353, 18, 24, 9, 13, 2132, 16, 2763, 18, 8375, 6189, 1919, 16, 10060, 16, 3]}, "items": [{"id": "p_841", "content": "Gastrointestinal Hemorrhage [SEP] Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 10489, 3, 7633, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_842", "content": "seizures [SEP]  and 29 (41.4%) patients, respectively. Gastrointestinal bleed, seizures, infection, and acute renal failure were documented in seven (1", "tokenized_content": [2, 10060, 3, 1930, 3230, 12, 4353, 18, 24, 9, 13, 2132, 16, 2763, 18, 8375, 6189, 1919, 16, 10060, 16, 2909, 16, 1930, 3939, 4604, 4574, 1985, 6974, 1922, 5260, 3]}, "items": [{"id": "p_842", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_843", "content": "infection [SEP] nts. Another 15 (1.2%) had ATT and simultaneous hepatitis virus infection. In 44 (62.8%) patients, ATT was prescribed empirically without", "tokenized_content": [2, 2909, 3, 17969, 18, 3741, 2461, 12, 21, 18, 22, 9, 13, 2430, 3099, 1930, 5710, 7977, 3413, 2909, 18, 1922, 4044, 12, 5374, 18, 28, 9, 13, 2132, 16, 3]}, "items": [{"id": "p_843", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_844", "content": "acute renal failure [SEP]  respectively. Gastrointestinal bleed, seizures, infection, and acute renal failure were documented in seven (10%), five (7.1%), 26 (37.1%), and se", "tokenized_content": [2, 3939, 4604, 4574, 3, 2763, 18, 8375, 6189, 1919, 16, 10060, 16, 2909, 16, 1930, 3939, 4604, 4574, 1985, 6974, 1922, 5260, 12, 2119, 9, 13, 16, 3628, 12, 27, 3]}, "items": [{"id": "p_844", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_845", "content": "hepatitis E [SEP]  (37.1%), and seven (10%) patients, respectively. Compared with hepatitis E virus (HEV) and non-A non-E-induced ALF, ATT-ALF patients had n", "tokenized_content": [2, 7977, 47, 3, 12, 3191, 18, 21, 9, 13, 16, 1930, 5260, 12, 2119, 9, 13, 2132, 16, 2763, 18, 2452, 1956, 7977, 47, 3413, 12, 19791, 13, 1930, 2447, 3]}, "items": [{"id": "p_845", "content": "Hepatitis E [SEP] Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HE", "score": 1, "type": null, "tokenized_content": [2, 7977, 47, 3, 3939, 4531, 1927, 1920, 3568, 1922, 5209, 31, 4189, 2007, 7977, 47, 3413, 16, 43, 2447, 17, 11262, 1007, 2957, 17, 10338, 3146, 3413, 18, 2551, 1942, 2234, 3]}]}
{"query": {"id": "q_846", "content": "bilirubin [SEP] nalysis, three factors independently predicted mortality: serum bilirubin (>or=10.8 mg/dL), prothrombin time (PT) prolongation (>or=26 se", "tokenized_content": [2, 15702, 3, 13120, 4662, 16, 2559, 2790, 6407, 4396, 3885, 30, 3256, 15702, 12, 34, 2014, 33, 2119, 18, 28, 2786, 19, 5268, 13, 16, 23976, 2367, 12, 4401, 13, 3]}, "items": [{"id": "p_846", "content": "Bilirubin [SEP] A bile pigment that is a degradation product of HEME.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15702, 3, 43, 9619, 12905, 1988, 1977, 43, 4877, 4863, 1927, 10954, 18, 3]}]}
{"query": {"id": "q_847", "content": "Central nervous system complications [SEP] Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pe", "tokenized_content": [2, 4101, 7580, 2433, 5021, 3, 4101, 7580, 2433, 5021, 2409, 2311, 1927, 3939, 24403, 8111, 1922, 43, 2957, 2737, 3]}, "items": [{"id": "p_847", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_848", "content": "acute lymphoblastic leukemia [SEP] Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution.", "tokenized_content": [2, 3939, 24403, 8111, 3, 4101, 7580, 2433, 5021, 2409, 2311, 1927, 3939, 24403, 8111, 1922, 43, 2957, 7460, 5115, 18, 3]}, "items": [{"id": "p_848", "content": "Precursor Cell Lymphoblastic Leukemia-Lymphoma [SEP] A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and ot", "score": 1, "type": null, "tokenized_content": [2, 7897, 2024, 24403, 8111, 17, 8636, 3, 43, 12132, 4378, 2007, 6754, 1927, 1920, 11751, 2024, 10416, 4523, 1942, 9122, 3541, 10088, 1922, 1920, 6599, 1930, 7608, 3]}]}
{"query": {"id": "q_849", "content": "Central nervous system (CNS) complications [SEP] Central nervous system (CNS) complications during treatment of childhood acute lymphoblastic leukemia (ALL", "tokenized_content": [2, 4101, 7580, 2433, 12, 7520, 13, 5021, 3, 4101, 7580, 2433, 12, 7520, 13, 5021, 2409, 2311, 1927, 7238, 3939, 24403, 8111, 12, 2136, 3]}, "items": [{"id": "p_849", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_850", "content": "acute lymphoblastic leukemia [SEP] ervous system (CNS) complications during treatment of childhood acute lymphoblastic leukemia (ALL) remain a challenging clinical problem. Outcome improvemen", "tokenized_content": [2, 3939, 24403, 8111, 3, 2668, 15525, 1957, 2433, 12, 7520, 13, 5021, 2409, 2311, 1927, 7238, 3939, 24403, 8111, 12, 2136, 13, 5555, 43, 8764, 2535, 4915, 18, 3924, 3326, 3]}, "items": [{"id": "p_850", "content": "Precursor Cell Lymphoblastic Leukemia-Lymphoma [SEP] A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and ot", "score": 1, "type": null, "tokenized_content": [2, 7897, 2024, 24403, 8111, 17, 8636, 3, 43, 12132, 4378, 2007, 6754, 1927, 1920, 11751, 2024, 10416, 4523, 1942, 9122, 3541, 10088, 1922, 1920, 6599, 1930, 7608, 3]}]}
{"query": {"id": "q_851", "content": "ALL [SEP] ons during treatment of childhood acute lymphoblastic leukemia (ALL) remain a challenging clinical problem. Outcome improvement wit", "tokenized_content": [2, 2136, 3, 24335, 2409, 2311, 1927, 7238, 3939, 24403, 8111, 12, 2136, 13, 5555, 43, 8764, 2535, 4915, 18, 3924, 4990, 16086, 3]}, "items": [{"id": "p_851", "content": "Precursor Cell Lymphoblastic Leukemia-Lymphoma [SEP] A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and ot", "score": 1, "type": null, "tokenized_content": [2, 7897, 2024, 24403, 8111, 17, 8636, 3, 43, 12132, 4378, 2007, 6754, 1927, 1920, 11751, 2024, 10416, 4523, 1942, 9122, 3541, 10088, 1922, 1920, 6599, 1930, 7608, 3]}]}
{"query": {"id": "q_852", "content": "neurological complications [SEP] everity of adverse events. This study analyzed the incidence of neurological complications during ALL treatment in a single pediatric institution, focusin", "tokenized_content": [2, 7605, 5021, 3, 4264, 1999, 1927, 5246, 3916, 18, 2052, 2161, 3265, 1920, 4332, 1927, 7605, 5021, 2409, 2136, 2311, 1922, 43, 2957, 7460, 5115, 16, 3691, 1921, 3]}, "items": [{"id": "p_852", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_853", "content": "leukemic infiltration [SEP]  electrophysiological findings. Exclusion criteria included CNS leukemic infiltration at diagnosis, therapy-related peripheral neuropathy, late-onset", "tokenized_content": [2, 17866, 8946, 3, 13189, 3056, 18, 7901, 4164, 3063, 7520, 17866, 8946, 2019, 3574, 16, 3181, 17, 2712, 5009, 13177, 16, 5058, 17, 4727, 3]}, "items": [{"id": "p_853", "content": "Leukemic Infiltration [SEP] A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukem", "score": 1, "type": null, "tokenized_content": [2, 17866, 8946, 3, 43, 11896, 3185, 1922, 8111, 1922, 2154, 17866, 2094, 6191, 2010, 3425, 7393, 2019, 2967, 3587, 1927, 1920, 2573, 18, 2136, 3584, 1927, 22823, 3]}]}
{"query": {"id": "q_854", "content": "peripheral neuropathy [SEP] ncluded CNS leukemic infiltration at diagnosis, therapy-related peripheral neuropathy, late-onset encephalopathy, or long-term neurocognitive defects", "tokenized_content": [2, 5009, 13177, 3, 30387, 4421, 7520, 17866, 8946, 2019, 3574, 16, 3181, 17, 2712, 5009, 13177, 16, 5058, 17, 4727, 19393, 16, 2014, 2815, 17, 2576, 18643, 6007, 3]}, "items": [{"id": "p_854", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_855", "content": "encephalopathy [SEP] at diagnosis, therapy-related peripheral neuropathy, late-onset encephalopathy, or long-term neurocognitive defects. During a 9-year period, w", "tokenized_content": [2, 19393, 3, 2019, 3574, 16, 3181, 17, 2712, 5009, 13177, 16, 5058, 17, 4727, 19393, 16, 2014, 2815, 17, 2576, 18643, 6007, 18, 2409, 43, 29, 17, 2476, 3047, 16, 3]}, "items": [{"id": "p_855", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_856", "content": "neurocognitive defects [SEP]  peripheral neuropathy, late-onset encephalopathy, or long-term neurocognitive defects. During a 9-year period, we retrospectively collected 27 neurol", "tokenized_content": [2, 18643, 6007, 3, 5009, 13177, 16, 5058, 17, 4727, 19393, 16, 2014, 2815, 17, 2576, 18643, 6007, 18, 2409, 43, 29, 17, 2476, 3047, 16, 2038, 11601, 3651, 3225, 20325, 3]}, "items": [{"id": "p_856", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_857", "content": "leukoencephalopathy [SEP] -line protocol. CNS complications included posterior reversible leukoencephalopathy syndrome (n = 10), stroke (n = 5), temporal lobe epilepsy (n = ", "tokenized_content": [2, 5104, 29159, 6522, 3, 17, 2823, 4478, 18, 7520, 5021, 3063, 5545, 10743, 5104, 29159, 6522, 4741, 12, 56, 33, 2119, 13, 16, 5235, 12, 56, 33, 25, 13, 16, 3]}, "items": [{"id": "p_857", "content": "Leukoencephalopathies [SEP] Any of various diseases affecting the white matter of the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5104, 29159, 16038, 3, 2967, 1927, 3425, 3902, 7359, 1920, 4511, 6537, 1927, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_858", "content": "stroke [SEP] ded posterior reversible leukoencephalopathy syndrome (n = 10), stroke (n = 5), temporal lobe epilepsy (n = 2), high-dose methotrexate", "tokenized_content": [2, 5235, 3, 11481, 5545, 10743, 5104, 29159, 6522, 4741, 12, 56, 33, 2119, 13, 16, 5235, 12, 56, 33, 25, 13, 16, 5338, 9581, 9741, 12, 56, 33, 22, 13, 3]}, "items": [{"id": "p_858", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_859", "content": "temporal lobe epilepsy [SEP] versible leukoencephalopathy syndrome (n = 10), stroke (n = 5), temporal lobe epilepsy (n = 2), high-dose methotrexate toxicity (n = 2), syndrome of i", "tokenized_content": [2, 5338, 9581, 9741, 3, 3162, 2563, 5104, 29159, 6522, 4741, 12, 56, 33, 2119, 13, 16, 5235, 12, 56, 33, 25, 13, 16, 5338, 9581, 9741, 12, 56, 33, 22, 3]}, "items": [{"id": "p_859", "content": "Epilepsy, Temporal Lobe [SEP] A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lob", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 5338, 9581, 3, 43, 5363, 17, 2712, 12, 8083, 13, 2386, 1927, 9741, 4378, 2007, 7457, 10060, 1988, 10149, 2037, 10334, 2651, 1920, 5338, 6948, 3]}]}
{"query": {"id": "q_860", "content": "methotrexate [SEP]  10), stroke (n = 5), temporal lobe epilepsy (n = 2), high-dose methotrexate toxicity (n = 2), syndrome of inappropriate antidiuretic hormon", "tokenized_content": [2, 18031, 3, 2119, 13, 16, 5235, 12, 56, 33, 25, 13, 16, 5338, 9581, 9741, 12, 56, 33, 22, 13, 16, 2149, 17, 3253, 18031, 5532, 12, 56, 33, 22, 3]}, "items": [{"id": "p_860", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_861", "content": "toxicity [SEP] (n = 5), temporal lobe epilepsy (n = 2), high-dose methotrexate toxicity (n = 2), syndrome of inappropriate antidiuretic hormone secreti", "tokenized_content": [2, 5532, 3, 12, 56, 33, 25, 13, 16, 5338, 9581, 9741, 12, 56, 33, 22, 13, 16, 2149, 17, 3253, 18031, 5532, 12, 56, 33, 22, 13, 16, 4741, 1927, 3]}, "items": [{"id": "p_861", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_862", "content": "inappropriate antidiuretic hormone secretion [SEP] y (n = 2), high-dose methotrexate toxicity (n = 2), syndrome of inappropriate antidiuretic hormone secretion (n = 1), and other unclassified events (n = 7). In conclusion, ", "tokenized_content": [2, 13770, 22576, 15766, 6365, 5512, 3, 67, 12, 56, 33, 22, 13, 16, 2149, 17, 3253, 18031, 5532, 12, 56, 33, 22, 13, 16, 4741, 1927, 13770, 22576, 15766, 6365, 3]}, "items": [{"id": "p_862", "content": "Inappropriate ADH Syndrome [SEP] A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of A", "score": 1, "type": null, "tokenized_content": [2, 13770, 21918, 4741, 3, 43, 2625, 1927, 29758, 6026, 1930, 4604, 7012, 3257, 6898, 1942, 4592, 6528, 12924, 1916, 1927, 3362, 13315, 3864, 2037, 7637, 4012, 1927, 43, 3]}]}
{"query": {"id": "q_863", "content": "capecitabine [SEP] Safety of capecitabine: a review.", "tokenized_content": [2, 28720, 3, 5407, 1927, 28720, 30, 43, 3043, 18, 3]}, "items": [{"id": "p_863", "content": "capecitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28720, 3, 3]}]}
{"query": {"id": "q_864", "content": "5-fluorouracil [SEP] IMPORTANCE OF THE FIELD: Fluoropyrimidines, in particular 5-fluorouracil (5-FU), have been the mainstay of treatment for several solid t", "tokenized_content": [2, 25, 17, 21353, 3, 4737, 1927, 1920, 3559, 30, 16191, 18425, 29899, 1036, 16, 1922, 3278, 25, 17, 21353, 12, 25, 17, 7391, 13, 16, 2162, 2252, 1920, 30124, 1927, 3]}, "items": [{"id": "p_864", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_865", "content": "5-FU [SEP]  OF THE FIELD: Fluoropyrimidines, in particular 5-fluorouracil (5-FU), have been the mainstay of treatment for several solid tumors,", "tokenized_content": [2, 25, 17, 7391, 3, 1927, 1920, 3559, 30, 16191, 18425, 29899, 1036, 16, 1922, 3278, 25, 17, 21353, 12, 25, 17, 7391, 13, 16, 2162, 2252, 1920, 30124, 1927, 2311, 3]}, "items": [{"id": "p_865", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_866", "content": "tumors [SEP] l (5-FU), have been the mainstay of treatment for several solid tumors, including colorectal, breast and head and neck cancers, for > ", "tokenized_content": [2, 3861, 3, 54, 12, 25, 17, 7391, 13, 16, 2162, 2252, 1920, 30124, 1927, 2311, 1958, 2980, 5358, 3861, 16, 2710, 7820, 16, 3739, 1930, 4469, 1930, 7467, 5717, 16, 3]}, "items": [{"id": "p_866", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_867", "content": "head and neck cancers [SEP] ment for several solid tumors, including colorectal, breast and head and neck cancers, for > 40 years. AREAS COVERED IN THIS REVIEW: This article rev", "tokenized_content": [2, 4469, 1930, 7467, 5717, 3, 11567, 1958, 2980, 5358, 3861, 16, 2710, 7820, 16, 3739, 1930, 4469, 1930, 7467, 5717, 16, 1958, 34, 3040, 2739, 18, 3957, 8710, 1922, 2052, 3]}, "items": [{"id": "p_867", "content": "Head and Neck Neoplasms [SEP] Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus.", "score": 1, "type": null, "tokenized_content": [2, 4469, 1930, 7467, 15347, 3, 3793, 2960, 3861, 2014, 2539, 11894, 2037, 1920, 9565, 7553, 1927, 1920, 3178, 31, 4726, 8568, 31, 18421, 6907, 14272, 31, 27443, 31, 1930, 6775, 16749, 18, 3]}]}
{"query": {"id": "q_868", "content": "capecitabine [SEP] S REVIEW: This article reviews the pharmacology and efficacy of capecitabine with a special emphasis on its safety. WHAT THE READER WILL GAI", "tokenized_content": [2, 28720, 3, 61, 3043, 30, 2052, 5868, 8617, 1920, 18374, 1930, 4348, 1927, 28720, 1956, 43, 5180, 12286, 1990, 2496, 5407, 18, 4663, 1920, 10571, 2832, 4357, 1033, 3]}, "items": [{"id": "p_868", "content": "capecitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28720, 3, 3]}]}
{"query": {"id": "q_869", "content": "renal and kidney disease [SEP] bine in special populations such as patients with advanced age, renal and kidney disease. We also explore different dosing and schedules of capecitabine", "tokenized_content": [2, 4604, 1930, 5245, 2573, 3, 8768, 1021, 1922, 5180, 4098, 2427, 1966, 2132, 1956, 5570, 2632, 16, 4604, 1930, 5245, 2573, 18, 2038, 2222, 6414, 2413, 10654, 1930, 19811, 1927, 3]}, "items": [{"id": "p_869", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_870", "content": "Capecitabine [SEP] nd schedules of capecitabine administration. TAKE HOME MESSAGE: Capecitabine is an oral prodrug of 5-FU and was developed to fulfill the nee", "tokenized_content": [2, 28720, 3, 8026, 19811, 1927, 28720, 4183, 18, 6132, 4502, 14525, 30, 28720, 1977, 1925, 4726, 21499, 1927, 25, 17, 7391, 1930, 1982, 3530, 1942, 20809, 1920, 2069, 1021, 3]}, "items": [{"id": "p_870", "content": "capecitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28720, 3, 3]}]}
{"query": {"id": "q_871", "content": "diarrhea [SEP] s. The most commonly reported toxic effects of capecitabine are diarrhea, nausea, vomiting, stomatitis and hand-foot syndrome. Capecitab", "tokenized_content": [2, 11904, 3, 61, 18, 1920, 2501, 5384, 2568, 6161, 2564, 1927, 28720, 2032, 11904, 16, 13759, 16, 13954, 16, 9347, 6219, 1930, 3897, 17, 8135, 4741, 18, 28268, 9909, 1014, 3]}, "items": [{"id": "p_871", "content": "Diarrhea [SEP] An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of wa", "score": 1, "type": null, "tokenized_content": [2, 11904, 3, 1925, 2502, 5875, 1999, 2014, 3261, 9592, 1927, 18610, 16, 2427, 1966, 9659, 14839, 18, 12295, 9592, 1977, 2712, 1942, 1920, 3400, 1927, 4114, 3]}]}
{"query": {"id": "q_872", "content": "nausea [SEP] t commonly reported toxic effects of capecitabine are diarrhea, nausea, vomiting, stomatitis and hand-foot syndrome. Capecitabine has ", "tokenized_content": [2, 13759, 3, 62, 5384, 2568, 6161, 2564, 1927, 28720, 2032, 11904, 16, 13759, 16, 13954, 16, 9347, 6219, 1930, 3897, 17, 8135, 4741, 18, 28720, 2258, 3]}, "items": [{"id": "p_872", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_873", "content": "vomiting [SEP] ly reported toxic effects of capecitabine are diarrhea, nausea, vomiting, stomatitis and hand-foot syndrome. Capecitabine has a well-est", "tokenized_content": [2, 13954, 3, 7518, 2568, 6161, 2564, 1927, 28720, 2032, 11904, 16, 13759, 16, 13954, 16, 9347, 6219, 1930, 3897, 17, 8135, 4741, 18, 28720, 2258, 43, 2486, 17, 3255, 3]}, "items": [{"id": "p_873", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_874", "content": "stomatitis [SEP] d toxic effects of capecitabine are diarrhea, nausea, vomiting, stomatitis and hand-foot syndrome. Capecitabine has a well-established saf", "tokenized_content": [2, 9347, 6219, 3, 46, 6161, 2564, 1927, 28720, 2032, 11904, 16, 13759, 16, 13954, 16, 9347, 6219, 1930, 3897, 17, 8135, 4741, 18, 28720, 2258, 43, 2486, 17, 4379, 4345, 3]}, "items": [{"id": "p_874", "content": "Stomatitis [SEP] INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9347, 6219, 3, 4531, 1927, 1920, 3793, 3878, 1927, 1920, 11701, 16, 2427, 1966, 9680, 31, 19471, 31, 12485, 17370, 31, 1930, 3178, 18, 3]}]}
{"query": {"id": "q_875", "content": "hand-foot syndrome [SEP]  of capecitabine are diarrhea, nausea, vomiting, stomatitis and hand-foot syndrome. Capecitabine has a well-established safety profile and can be ", "tokenized_content": [2, 3897, 17, 8135, 4741, 3, 1927, 28720, 2032, 11904, 16, 13759, 16, 13954, 16, 9347, 6219, 1930, 3897, 17, 8135, 4741, 18, 28720, 2258, 43, 2486, 17, 4379, 5407, 5174, 3]}, "items": [{"id": "p_875", "content": "Hand-Foot Syndrome [SEP] Chemotherapy-induced dermal side effects that are associated with the use of various CYTOSTATIC AGENTS. Symptoms range from mild", "score": 1, "type": null, "tokenized_content": [2, 3897, 17, 8135, 4741, 3, 5318, 17, 2719, 14230, 4159, 2564, 1988, 2032, 2458, 1956, 1920, 2485, 1927, 3425, 5521, 3857, 2002, 4820, 18, 3601, 3109, 2037, 5809, 3]}]}
{"query": {"id": "q_876", "content": "renal dysfunctions [SEP]  can be given safely to patients with advanced age, hepatic and renal dysfunctions.", "tokenized_content": [2, 4604, 24199, 3, 2112, 1998, 3258, 17587, 1942, 2132, 1956, 5570, 2632, 16, 6095, 1930, 4604, 24199, 18, 3]}, "items": [{"id": "p_876", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_877", "content": "neurotensin [SEP] Effects of pallidal neurotensin on haloperidol-induced parkinsonian catalepsy: behavioral and e", "tokenized_content": [2, 9124, 9261, 3, 2564, 1927, 12574, 3825, 1024, 9124, 9261, 1990, 25107, 17, 2719, 10124, 3122, 4233, 9431, 1012, 30, 5343, 1930, 47, 3]}, "items": [{"id": "p_877", "content": "Neurotensin [SEP] A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stim", "score": 1, "type": null, "tokenized_content": [2, 9124, 9261, 3, 43, 12186, 3500, 5083, 3695, 8410, 2410, 2261, 3937, 2037, 1920, 13708, 18, 2176, 2258, 2252, 2522, 1942, 4769, 16453, 1922, 1920, 3067, 16, 1942, 2801, 3]}]}
{"query": {"id": "q_878", "content": "haloperidol [SEP] Effects of pallidal neurotensin on haloperidol-induced parkinsonian catalepsy: behavioral and electrophysiolog", "tokenized_content": [2, 25107, 3, 2564, 1927, 12574, 3825, 1024, 9124, 9261, 1990, 25107, 17, 2719, 10124, 3122, 4233, 9431, 1012, 30, 5343, 1930, 11350, 11149, 2021, 3]}, "items": [{"id": "p_878", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_879", "content": "parkinsonian catalepsy [SEP] Effects of pallidal neurotensin on haloperidol-induced parkinsonian catalepsy: behavioral and electrophysiological studies.", "tokenized_content": [2, 10124, 3122, 4233, 9431, 1012, 3, 2564, 1927, 12574, 3825, 1024, 9124, 9261, 1990, 25107, 17, 2719, 10124, 3122, 4233, 9431, 1012, 30, 5343, 1930, 13189, 2351, 18, 3]}, "items": [{"id": "p_879", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_880", "content": "neurotensin [SEP] evious studies have indicated that the globus pallidus receives neurotensinergic innervation from the striatum, and systemic administration", "tokenized_content": [2, 9124, 9261, 3, 2180, 4836, 2351, 2162, 3391, 1988, 1920, 4317, 1957, 12574, 10015, 1036, 17561, 9124, 9261, 5237, 19099, 2037, 1920, 11259, 16, 1930, 5510, 4183, 3]}, "items": [{"id": "p_880", "content": "Neurotensin [SEP] A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stim", "score": 1, "type": null, "tokenized_content": [2, 9124, 9261, 3, 43, 12186, 3500, 5083, 3695, 8410, 2410, 2261, 3937, 2037, 1920, 13708, 18, 2176, 2258, 2252, 2522, 1942, 4769, 16453, 1922, 1920, 3067, 16, 1942, 2801, 3]}]}
{"query": {"id": "q_881", "content": "haloperidol [SEP] udy aimed to investigate the effects of pallidal neurotensin on haloperidol-induced parkinsonian symptoms. METHODS: Behavioral experiments ", "tokenized_content": [2, 25107, 3, 19803, 1012, 6822, 1942, 4482, 1920, 2564, 1927, 12574, 3825, 1024, 9124, 9261, 1990, 25107, 17, 2719, 10124, 3122, 3601, 18, 2860, 30, 5343, 3144, 3]}, "items": [{"id": "p_881", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_882", "content": "parkinsonian symptoms [SEP] gate the effects of pallidal neurotensin on haloperidol-induced parkinsonian symptoms. METHODS: Behavioral experiments and electrophysiological recor", "tokenized_content": [2, 10124, 3122, 3601, 3, 11898, 1920, 2564, 1927, 12574, 3825, 1024, 9124, 9261, 1990, 25107, 17, 2719, 10124, 3122, 3601, 18, 2860, 30, 5343, 3144, 1930, 13189, 29326, 1005, 3]}, "items": [{"id": "p_882", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_883", "content": "parkinsonian catalepsy [SEP] urotensin into the globus pallidus reversed haloperidol-induced parkinsonian catalepsy in rats. Electrophysiological recordings showed that microinjec", "tokenized_content": [2, 10124, 3122, 4233, 9431, 1012, 3, 14984, 2777, 6777, 2460, 1920, 4317, 1957, 12574, 10015, 1036, 9432, 25107, 17, 2719, 10124, 3122, 4233, 9431, 1012, 1922, 3615, 18, 13189, 9276, 3]}, "items": [{"id": "p_883", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_884", "content": "neurotensin type-1 receptor antagonist [SEP] ons in the presence of systemic haloperidol administration. The neurotensin type-1 receptor antagonist SR48692 blocked both the behavioral and the electrophysiologica", "tokenized_content": [2, 9124, 9261, 2601, 17, 21, 3148, 8151, 3, 24335, 1922, 1920, 2990, 1927, 5510, 25107, 4183, 18, 1920, 9124, 9261, 2601, 17, 21, 3148, 8151, 4581, 28839, 11884, 6923, 2321, 3]}, "items": [{"id": "p_884", "content": "SR 48692 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4581, 26921, 11884, 3, 3]}]}
{"query": {"id": "q_885", "content": "SR48692 [SEP] idol administration. The neurotensin type-1 receptor antagonist SR48692 blocked both the behavioral and the electrophysiological effect", "tokenized_content": [2, 4581, 28839, 11884, 3, 23783, 1024, 4183, 18, 1920, 9124, 9261, 2601, 17, 21, 3148, 8151, 4581, 28839, 11884, 6923, 2321, 1920, 5343, 1930, 1920, 13189, 2495, 3]}, "items": [{"id": "p_885", "content": "SR 48692 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4581, 26921, 11884, 3, 3]}]}
{"query": {"id": "q_886", "content": "depression [SEP] Antihypertensive drugs and depression: a reappraisal.", "tokenized_content": [2, 4621, 3, 16439, 4195, 1930, 4621, 30, 43, 27837, 13399, 16516, 18, 3]}, "items": [{"id": "p_886", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_887", "content": "hypertensive [SEP] Eighty-nine new referral hypertensive out-patients and 46 new referral non-hypertensive chronically p", "tokenized_content": [2, 11706, 3, 17286, 17, 6360, 2814, 11033, 11706, 2397, 17, 2132, 1930, 4182, 2814, 11033, 2447, 17, 11706, 16132, 58, 3]}, "items": [{"id": "p_887", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_888", "content": "depression [SEP] intervals for one year. The results showed a high prevalence of depression in both groups of patients, with no preponderance in the hypert", "tokenized_content": [2, 4621, 3, 6087, 1958, 2340, 2476, 18, 1920, 2274, 2594, 43, 2149, 4077, 1927, 4621, 1922, 2321, 2671, 1927, 2132, 16, 1956, 2239, 10719, 13509, 2152, 1922, 1920, 4506, 3]}, "items": [{"id": "p_888", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_889", "content": "Hypertensive [SEP] s of patients, with no preponderance in the hypertensive group. Hypertensive patients with psychiatric histories had a higher prevalence of ", "tokenized_content": [2, 11706, 3, 61, 1927, 2132, 16, 1956, 2239, 10719, 13509, 2152, 1922, 1920, 11706, 2210, 18, 11706, 2132, 1956, 7652, 17383, 2430, 43, 2580, 4077, 1927, 3]}, "items": [{"id": "p_889", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_890", "content": "psychiatric [SEP] onderance in the hypertensive group. Hypertensive patients with psychiatric histories had a higher prevalence of depression than the compar", "tokenized_content": [2, 7652, 3, 1990, 2179, 2152, 1922, 1920, 11706, 2210, 18, 11706, 2132, 1956, 7652, 17383, 2430, 43, 2580, 4077, 1927, 4621, 2254, 1920, 2238, 3]}, "items": [{"id": "p_890", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_891", "content": "depressions [SEP] son patients. This was accounted for by a significant number of depressions occurring in methyl dopa treated patients with psychiatric hist", "tokenized_content": [2, 4621, 1036, 3, 9337, 2132, 18, 2052, 1982, 9448, 1958, 2007, 43, 2228, 2529, 1927, 4621, 1036, 6966, 1922, 4963, 19428, 2868, 2132, 1956, 7652, 2968, 3]}, "items": [{"id": "p_891", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_892", "content": "methyl dopa [SEP] counted for by a significant number of depressions occurring in methyl dopa treated patients with psychiatric histories.", "tokenized_content": [2, 4963, 19428, 3, 9007, 1958, 2007, 43, 2228, 2529, 1927, 4621, 1036, 6966, 1922, 4963, 19428, 2868, 2132, 1956, 7652, 17383, 18, 3]}, "items": [{"id": "p_892", "content": "Methyldopa [SEP] An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an ant", "score": 1, "type": null, "tokenized_content": [2, 4963, 22389, 4302, 3, 1925, 4595, 17, 22, 13672, 7829, 1988, 2258, 2321, 4101, 1930, 5009, 7580, 2433, 2564, 18, 2496, 3065, 2535, 2485, 1977, 1966, 1925, 4942, 3]}]}
{"query": {"id": "q_893", "content": "nitroprusside [SEP] Pulmonary shunt and cardiovascular responses to CPAP during nitroprusside-induced hypotension.", "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 5352, 17157, 1930, 5321, 3387, 1942, 22991, 2409, 8686, 2047, 3468, 2261, 17, 2719, 16453, 18, 3]}, "items": [{"id": "p_893", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_894", "content": "hypotension [SEP] d cardiovascular responses to CPAP during nitroprusside-induced hypotension.", "tokenized_content": [2, 16453, 3, 46, 5321, 3387, 1942, 22991, 2409, 8686, 2047, 3468, 2261, 17, 2719, 16453, 18, 3]}, "items": [{"id": "p_894", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_895", "content": "sodium nitroprusside [SEP] ry shunt (QS/QT) were investigated in 12 dogs before and during sodium nitroprusside infusion that decreased mean arterial blood pressure 40-50 per ", "tokenized_content": [2, 5227, 8686, 2047, 3468, 2261, 3, 18650, 17157, 12, 15178, 19, 8877, 13, 1985, 3845, 1922, 2369, 7894, 3119, 1930, 2409, 5227, 8686, 2047, 3468, 2261, 7386, 1988, 3261, 2667, 3]}, "items": [{"id": "p_895", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_896", "content": "nitroprusside [SEP] t (QS/QT) were investigated in 12 dogs before and during sodium nitroprusside infusion that decreased mean arterial blood pressure 40-50 per ", "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 62, 12, 15178, 19, 8877, 13, 1985, 3845, 1922, 2369, 7894, 3119, 1930, 2409, 5227, 8686, 2047, 3468, 2261, 7386, 1988, 3261, 2667, 6624, 2877, 3]}, "items": [{"id": "p_896", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_897", "content": "H2O [SEP] od pressure 40-50 per cent. Before nitroprusside infusion, 5 cm H2O CPAP significantly, P less than .05, decreased arterial blood p", "tokenized_content": [2, 11003, 3, 4426, 3772, 3040, 17, 2761, 2079, 3208, 18, 3119, 8686, 2047, 3468, 2261, 7386, 16, 25, 3195, 11003, 22991, 2567, 16, 58, 2941, 2254, 18, 2914, 16, 3261, 3]}, "items": [{"id": "p_897", "content": "Water [SEP] A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substa", "score": 1, "type": null, "tokenized_content": [2, 3224, 3, 43, 4021, 16, 12685, 5427, 16, 13891, 5427, 5875, 1988, 1977, 4415, 1958, 2501, 4027, 1930, 4496, 3308, 1930, 1977, 1925, 7526, 7596, 1958, 3086, 5879, 1019, 3]}]}
{"query": {"id": "q_898", "content": "decrease in arterial blood pressure [SEP] en cm H2O CPAP before nitroprusside infusion produced a further decrease in arterial blood pressure and significantly increased heart rate and decreased cardiac ou", "tokenized_content": [2, 3714, 1922, 6624, 2877, 3772, 3, 2066, 3195, 11003, 22991, 3119, 8686, 2047, 3468, 2261, 7386, 4152, 43, 2520, 3714, 1922, 6624, 2877, 3772, 1930, 2567, 2502, 4003, 2769, 1930, 3]}, "items": [{"id": "p_898", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_899", "content": "decreased cardiac output [SEP] erial blood pressure and significantly increased heart rate and decreased cardiac output and QS/QT. Nitroprusside caused significant decreases in arteri", "tokenized_content": [2, 3261, 4435, 6647, 3, 2668, 2086, 2877, 3772, 1930, 2567, 2502, 4003, 2769, 1930, 3261, 4435, 6647, 1930, 15178, 19, 8877, 18, 8686, 2047, 3468, 2261, 4189, 2228, 6386, 1922, 3]}, "items": [{"id": "p_899", "content": "Cardiac Output, Low [SEP] A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, in", "score": 1, "type": null, "tokenized_content": [2, 4435, 6647, 16, 2330, 3, 43, 3360, 1927, 28843, 2620, 2014, 11365, 4435, 6647, 2019, 6172, 2014, 2409, 3071, 18, 2176, 1977, 43, 6293, 1927, 5321, 3902, 16, 1922, 3]}]}
{"query": {"id": "q_900", "content": "Nitroprusside [SEP] ly increased heart rate and decreased cardiac output and QS/QT. Nitroprusside caused significant decreases in arterial blood pressure and sys", "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 7518, 2502, 4003, 2769, 1930, 3261, 4435, 6647, 1930, 15178, 19, 8877, 18, 8686, 2047, 3468, 2261, 4189, 2228, 6386, 1922, 6624, 2877, 3772, 1930, 3]}, "items": [{"id": "p_900", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_901", "content": "decreases in arterial blood pressure [SEP] ased cardiac output and QS/QT. Nitroprusside caused significant decreases in arterial blood pressure and systemic vascular resistance and increases in heart rate, b", "tokenized_content": [2, 6386, 1922, 6624, 2877, 3772, 3, 28826, 1007, 4435, 6647, 1930, 15178, 19, 8877, 18, 8686, 2047, 3468, 2261, 4189, 2228, 6386, 1922, 6624, 2877, 3772, 1930, 5510, 4541, 3554, 3]}, "items": [{"id": "p_901", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_902", "content": "bradycardia [SEP] Mediation of enhanced reflex vagal bradycardia by L-dopa via central dopamine formation in dogs.", "tokenized_content": [2, 26192, 3, 17041, 1927, 4256, 11573, 20653, 26192, 2007, 54, 17, 19428, 3454, 4101, 7964, 3337, 1922, 7894, 18, 3]}, "items": [{"id": "p_902", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_903", "content": "L-dopa [SEP] Mediation of enhanced reflex vagal bradycardia by L-dopa via central dopamine formation in dogs.", "tokenized_content": [2, 54, 17, 19428, 3, 17041, 1927, 4256, 11573, 20653, 26192, 2007, 54, 17, 19428, 3454, 4101, 7964, 3337, 1922, 7894, 18, 3]}, "items": [{"id": "p_903", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_904", "content": "dopamine [SEP] tion of enhanced reflex vagal bradycardia by L-dopa via central dopamine formation in dogs.", "tokenized_content": [2, 7964, 3, 8685, 1916, 1927, 4256, 11573, 20653, 26192, 2007, 54, 17, 19428, 3454, 4101, 7964, 3337, 1922, 7894, 18, 3]}, "items": [{"id": "p_904", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_905", "content": "L-Dopa [SEP] L-Dopa (5 mg/kg i.v.) decreased blood pressure and heart rate after ex", "tokenized_content": [2, 54, 17, 19428, 3, 54, 17, 19428, 12, 25, 2786, 19, 3621, 51, 18, 64, 18, 13, 3261, 2877, 3772, 1930, 4003, 2769, 2256, 1975, 3]}, "items": [{"id": "p_905", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_906", "content": "MK-486 [SEP] nd heart rate after extracerebral decarboxylase inhibition with MK-486 (25 mg/kg i.v.) in anesthetize MAO-inhibited dogs. In addition,", "tokenized_content": [2, 10539, 17, 26921, 3, 8026, 4003, 2769, 2256, 3439, 1959, 5444, 23922, 3523, 1956, 10539, 17, 26921, 12, 2637, 2786, 19, 3621, 51, 18, 64, 18, 13, 1922, 6176, 4988, 3]}, "items": [{"id": "p_906", "content": "Carbidopa [SEP] An inhibitor of DOPA DECARBOXYLASE, preventing conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce per", "score": 1, "type": null, "tokenized_content": [2, 3697, 15072, 4302, 3, 1925, 4106, 1927, 19428, 23922, 16, 8444, 7309, 1927, 26723, 1942, 7964, 18, 2176, 1977, 2251, 1922, 10124, 2573, 1942, 4412, 2079, 3]}]}
{"query": {"id": "q_907", "content": "MAO [SEP] rboxylase inhibition with MK-486 (25 mg/kg i.v.) in anesthetize MAO-inhibited dogs. In addition, reflex bradycardia caused by injec", "tokenized_content": [2, 21178, 3, 6160, 6644, 2051, 3523, 1956, 10539, 17, 26921, 12, 2637, 2786, 19, 3621, 51, 18, 64, 18, 13, 1922, 6176, 4988, 6931, 21178, 17, 5069, 7894, 18, 1922, 3]}, "items": [{"id": "p_907", "content": "Monoamine Oxidase [SEP] An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is l", "score": 1, "type": null, "tokenized_content": [2, 25368, 10488, 3, 1925, 4113, 1988, 17097, 1920, 5163, 30097, 8547, 1943, 1927, 10414, 6966, 25368, 1036, 18, 2176, 1977, 43, 26758, 17, 3165, 4113, 1988, 1977, 54, 3]}]}
{"query": {"id": "q_908", "content": "bradycardia [SEP] kg i.v.) in anesthetize MAO-inhibited dogs. In addition, reflex bradycardia caused by injected norepinephrine was significantly enhanced by", "tokenized_content": [2, 26192, 3, 3621, 51, 18, 64, 18, 13, 1922, 6176, 4988, 6931, 21178, 17, 5069, 7894, 18, 1922, 2459, 16, 11573, 26192, 4189, 2007, 5624, 16436, 1982, 2567, 4256, 2007, 3]}, "items": [{"id": "p_908", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_909", "content": "norepinephrine [SEP] ibited dogs. In addition, reflex bradycardia caused by injected norepinephrine was significantly enhanced by L-dopa, DL-Threo-dihydroxyphenyls", "tokenized_content": [2, 16436, 3, 6180, 2599, 7894, 18, 1922, 2459, 16, 11573, 26192, 4189, 2007, 5624, 16436, 1982, 2567, 4256, 2007, 54, 17, 19428, 16, 5268, 17, 6841, 1037, 17, 20684, 17616, 3]}, "items": [{"id": "p_909", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_910", "content": "L-dopa [SEP] caused by injected norepinephrine was significantly enhanced by L-dopa, DL-Threo-dihydroxyphenylserine had no effect on blood pressure", "tokenized_content": [2, 54, 17, 19428, 3, 4189, 2007, 5624, 16436, 1982, 2567, 4256, 2007, 54, 17, 19428, 16, 5268, 17, 6841, 1037, 17, 20684, 17616, 2199, 26337, 2430, 2239, 2495, 1990, 2877, 3]}, "items": [{"id": "p_910", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_911", "content": "DL-Threo-dihydroxyphenylserine [SEP] y injected norepinephrine was significantly enhanced by L-dopa, DL-Threo-dihydroxyphenylserine had no effect on blood pressure, heart rate or reflex responses", "tokenized_content": [2, 5268, 17, 6841, 1037, 17, 20684, 17616, 2199, 26337, 3, 67, 5624, 16436, 1982, 2567, 4256, 2007, 54, 17, 19428, 16, 5268, 17, 6841, 1037, 17, 20684, 17616, 2199, 26337, 3]}, "items": [{"id": "p_911", "content": "Droxidopa [SEP] A precursor of noradrenaline that is used in the treatment of parkinsonism. The racemic form (DL-threo-3,4-dihydroxyphenylserine", "score": 1, "type": null, "tokenized_content": [2, 8442, 18068, 22389, 4302, 3, 43, 7897, 1927, 22636, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 26214, 18, 1920, 7442, 4913, 2386, 12, 5268, 17, 6841, 1037, 17, 23, 16, 24, 17, 20684, 17616, 2199, 26337, 3]}]}
{"query": {"id": "q_912", "content": "FLA-63 [SEP] ood pressure, heart rate or reflex responses to norepinephrine. FLA-63, a dopamine-beta-oxidase inhibitor, did not have any effect on ", "tokenized_content": [2, 2300, 1019, 17, 4968, 3, 57, 1986, 3772, 16, 4003, 2769, 2014, 11573, 3387, 1942, 16436, 18, 2300, 1019, 17, 4968, 16, 43, 7964, 17, 4666, 17, 10488, 4106, 16, 3]}, "items": [{"id": "p_912", "content": "Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide [SEP] An inhibitor of the last step of noradrenaline biosynthesis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7266, 12, 24, 17, 4963, 17, 21, 17, 16350, 10984, 2116, 25823, 2199, 22523, 22780, 12831, 13, 11830, 3, 1925, 4106, 1927, 1920, 4691, 3537, 1927, 22636, 8132, 18, 3]}]}
{"query": {"id": "q_913", "content": "dopamine [SEP] re, heart rate or reflex responses to norepinephrine. FLA-63, a dopamine-beta-oxidase inhibitor, did not have any effect on the hypotens", "tokenized_content": [2, 7964, 3, 1964, 16, 4003, 2769, 2014, 11573, 3387, 1942, 16436, 18, 2300, 1019, 17, 4968, 16, 43, 7964, 17, 4666, 17, 10488, 4106, 16, 2811, 2084, 2162, 2967, 2495, 3]}, "items": [{"id": "p_913", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_914", "content": "hypotension [SEP] dopamine-beta-oxidase inhibitor, did not have any effect on the hypotension, bradycardia or reflex-enhancing effect of L-dopa. Pimozide did", "tokenized_content": [2, 16453, 3, 7964, 17, 4666, 17, 10488, 4106, 16, 2811, 2084, 2162, 2967, 2495, 1990, 1920, 16453, 16, 26192, 2014, 11573, 17, 9221, 2495, 1927, 54, 17, 19428, 18, 17019, 3]}, "items": [{"id": "p_914", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_915", "content": "Pimozide [SEP]  hypotension, bradycardia or reflex-enhancing effect of L-dopa. Pimozide did not affect the actions of L-dopa on blood pressure and hear", "tokenized_content": [2, 17019, 4490, 2261, 3, 16453, 16, 26192, 2014, 11573, 17, 9221, 2495, 1927, 54, 17, 19428, 18, 17019, 4490, 2261, 2811, 2084, 4081, 1920, 7728, 1927, 54, 17, 19428, 1990, 3]}, "items": [{"id": "p_915", "content": "Pimozide [SEP] A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression o", "score": 1, "type": null, "tokenized_content": [2, 17019, 4490, 2261, 3, 43, 18190, 16119, 2199, 10984, 2116, 5802, 1988, 1977, 3655, 1966, 1925, 17581, 5899, 1930, 1966, 1925, 5012, 1942, 25107, 1958, 1920, 6412, 57, 3]}]}
{"query": {"id": "q_916", "content": "5-HTP [SEP] phrine in addition to decreasing blood pressure and heart rate. 5-HTP (5 mg/kg i.v.) decreased blood pressure and heart rate and decr", "tokenized_content": [2, 25, 17, 5334, 1034, 3, 17252, 2053, 1922, 2459, 1942, 7742, 2877, 3772, 1930, 4003, 2769, 18, 25, 17, 5334, 1034, 12, 25, 2786, 19, 3621, 51, 18, 64, 18, 3]}, "items": [{"id": "p_916", "content": "5-Hydroxytryptophan [SEP] The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.\n   ", "score": 1, "type": null, "tokenized_content": [2, 25, 17, 8275, 30298, 2688, 1928, 3, 1920, 8426, 7897, 1922, 1920, 8132, 1927, 11153, 2037, 13489, 18, 2176, 1977, 2251, 1966, 1925, 29132, 1930, 14183, 18, 3]}]}
{"query": {"id": "q_917", "content": "Cocaine [SEP] Cocaine-induced myocardial infarction: clinical observations and pathog", "tokenized_content": [2, 9045, 3, 9045, 17, 2719, 6497, 8358, 30, 2535, 5184, 1930, 2450, 2021, 3]}, "items": [{"id": "p_917", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_918", "content": "myocardial infarction [SEP] Cocaine-induced myocardial infarction: clinical observations and pathogenetic considerations.", "tokenized_content": [2, 6497, 8358, 3, 9045, 17, 2719, 6497, 8358, 30, 2535, 5184, 1930, 7055, 3023, 12943, 18, 3]}, "items": [{"id": "p_918", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_919", "content": "cocaine [SEP]  published to date suggest several possible mechanisms by which cocaine may result in acute myocardial infarction. In individuals with ", "tokenized_content": [2, 9045, 3, 4586, 1942, 5699, 3220, 2980, 3216, 3531, 2007, 2154, 9045, 2278, 3211, 1922, 3939, 6497, 8358, 18, 1922, 3445, 1956, 3]}, "items": [{"id": "p_919", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_920", "content": "acute myocardial infarction [SEP] gest several possible mechanisms by which cocaine may result in acute myocardial infarction. In individuals with preexisting, high-grade coronary arterial ", "tokenized_content": [2, 3939, 6497, 8358, 3, 6919, 2980, 3216, 3531, 2007, 2154, 9045, 2278, 3211, 1922, 3939, 6497, 8358, 18, 1922, 3445, 1956, 21604, 16, 2149, 17, 4927, 5846, 6624, 3]}, "items": [{"id": "p_920", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_921", "content": "oxygen [SEP] myocardial infarction may result from an increase in myocardial oxygen demand associated with cocaine-induced increase in rate-pressur", "tokenized_content": [2, 4612, 3, 6497, 8358, 2278, 3211, 2037, 1925, 2760, 1922, 6497, 4612, 9749, 2458, 1956, 9045, 17, 2719, 2760, 1922, 2769, 17, 3477, 1949, 3]}, "items": [{"id": "p_921", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_922", "content": "atherosclerotic obstruction [SEP]  rate-pressure product. In other individuals with no underlying atherosclerotic obstruction, coronary occlusion may be due to spasm, thrombus, or both. Wit", "tokenized_content": [2, 13450, 10849, 3, 2769, 17, 3772, 4863, 18, 1922, 2303, 3445, 1956, 2239, 5030, 13450, 10849, 16, 5846, 10543, 2278, 1998, 2810, 1942, 24431, 16, 16705, 16, 2014, 2321, 18, 3]}, "items": [{"id": "p_922", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_923", "content": "coronary occlusion [SEP] her individuals with no underlying atherosclerotic obstruction, coronary occlusion may be due to spasm, thrombus, or both. With regard to spasm, t", "tokenized_content": [2, 5846, 10543, 3, 3656, 3445, 1956, 2239, 5030, 13450, 10849, 16, 5846, 10543, 2278, 1998, 2810, 1942, 24431, 16, 16705, 16, 2014, 2321, 18, 1956, 4623, 1942, 24431, 16, 62, 3]}, "items": [{"id": "p_923", "content": "Coronary Occlusion [SEP] Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 10543, 3, 4080, 23615, 1927, 2877, 3426, 2596, 2340, 1927, 1920, 5846, 9345, 16, 5394, 2037, 5846, 9824, 18, 3]}]}
{"query": {"id": "q_924", "content": "spasm [SEP] g atherosclerotic obstruction, coronary occlusion may be due to spasm, thrombus, or both. With regard to spasm, the clinical findings", "tokenized_content": [2, 24431, 3, 49, 13450, 10849, 16, 5846, 10543, 2278, 1998, 2810, 1942, 24431, 16, 16705, 16, 2014, 2321, 18, 1956, 4623, 1942, 24431, 16, 1920, 2535, 3056, 3]}, "items": [{"id": "p_924", "content": "Spasm [SEP] An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24431, 3, 1925, 28493, 8332, 1927, 43, 3760, 2014, 2210, 1927, 7848, 18, 24431, 1036, 2278, 8156, 7345, 3760, 2014, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_925", "content": "thrombus [SEP] osclerotic obstruction, coronary occlusion may be due to spasm, thrombus, or both. With regard to spasm, the clinical findings are large", "tokenized_content": [2, 16705, 3, 7579, 3823, 3153, 10849, 16, 5846, 10543, 2278, 1998, 2810, 1942, 24431, 16, 16705, 16, 2014, 2321, 18, 1956, 4623, 1942, 24431, 16, 1920, 2535, 3056, 2032, 3103, 3]}, "items": [{"id": "p_925", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_926", "content": "infarction [SEP] ible mechanisms by which cocaine may result in acute myocardial infarction. In individuals with preexisting, high-grade coronary arterial ", "tokenized_content": [2, 8358, 3, 6180, 1952, 3531, 2007, 2154, 9045, 2278, 3211, 1922, 3939, 6497, 8358, 18, 1922, 3445, 1956, 21604, 16, 2149, 17, 4927, 5846, 6624, 3]}, "items": [{"id": "p_926", "content": "Infarction [SEP] Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most", "score": 1, "type": null, "tokenized_content": [2, 8358, 3, 3337, 1927, 1925, 13389, 16, 2154, 1977, 7476, 1922, 2960, 2810, 1942, 3076, 7716, 3864, 2037, 10849, 1927, 2877, 9255, 16, 2501, 3]}]}
{"query": {"id": "q_927", "content": "thrombotic [SEP] alpha-mediated effects. Finally, the contribution of a primary, thrombotic effect of cocaine has not been excluded.", "tokenized_content": [2, 21039, 3, 4595, 17, 3434, 2564, 18, 4342, 16, 1920, 5100, 1927, 43, 3065, 16, 21039, 2495, 1927, 9045, 2258, 2084, 2252, 5450, 18, 3]}, "items": [{"id": "p_927", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_928", "content": "Rabbit syndrome [SEP] Rabbit syndrome, antidepressant use, and cerebral perfusion SPECT scan findings", "tokenized_content": [2, 6020, 4741, 3, 6020, 4741, 16, 14183, 2485, 16, 1930, 6329, 8368, 4544, 4519, 3056, 3]}, "items": [{"id": "p_928", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_929", "content": "antidepressant [SEP] Rabbit syndrome, antidepressant use, and cerebral perfusion SPECT scan findings.", "tokenized_content": [2, 14183, 3, 6020, 4741, 16, 14183, 2485, 16, 1930, 6329, 8368, 4544, 4519, 3056, 18, 3]}, "items": [{"id": "p_929", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_930", "content": "rabbit syndrome [SEP] The rabbit syndrome is an extrapyramidal side effect associated with chronic neurol", "tokenized_content": [2, 6020, 4741, 3, 1920, 6020, 4741, 1977, 1925, 21346, 3553, 25238, 1923, 4159, 2495, 2458, 1956, 3724, 20325, 3]}, "items": [{"id": "p_930", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_931", "content": "imipramine [SEP] oleptic therapy. Its occurrence in a patient being treated with imipramine is described, representing the first reported case of this synd", "tokenized_content": [2, 2042, 27085, 3, 12188, 13575, 3181, 18, 2496, 6564, 1922, 43, 2774, 3301, 2868, 1956, 2042, 27085, 1977, 2910, 16, 7479, 1920, 2561, 2568, 3087, 1927, 2052, 4404, 3]}, "items": [{"id": "p_931", "content": "Imipramine [SEP] The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-defici", "score": 1, "type": null, "tokenized_content": [2, 2042, 27085, 3, 1920, 29183, 12258, 13153, 14183, 18, 2176, 2258, 2252, 2251, 1922, 3044, 4621, 16, 10612, 30338, 6026, 16, 10275, 4621, 16, 4976, 17, 6428, 1033, 3]}]}
{"query": {"id": "q_932", "content": "antidepressants [SEP] ng the first reported case of this syndrome in conjunction with antidepressants. Repeated cerebral perfusion SPECT scans revealed decreased bas", "tokenized_content": [2, 17722, 3, 4375, 1920, 2561, 2568, 3087, 1927, 2052, 4741, 1922, 11799, 1956, 17722, 18, 5116, 6329, 8368, 4544, 8581, 3404, 3261, 2726, 3]}, "items": [{"id": "p_932", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_933", "content": "decreased basal ganglia perfusion [SEP] tidepressants. Repeated cerebral perfusion SPECT scans revealed decreased basal ganglia perfusion while the movement disorder was present, and a return to normal", "tokenized_content": [2, 3261, 5342, 13086, 8368, 3, 8685, 3695, 2109, 2356, 18, 5116, 6329, 8368, 4544, 8581, 3404, 3261, 5342, 13086, 8368, 2679, 1920, 5829, 4770, 1982, 2481, 16, 1930, 43, 7215, 3]}, "items": [{"id": "p_933", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_934", "content": "movement disorder [SEP] PECT scans revealed decreased basal ganglia perfusion while the movement disorder was present, and a return to normal perfusion when the rabbit s", "tokenized_content": [2, 5829, 4770, 3, 13494, 1031, 8581, 3404, 3261, 5342, 13086, 8368, 2679, 1920, 5829, 4770, 1982, 2481, 16, 1930, 43, 7215, 1942, 2791, 8368, 2469, 1920, 6020, 61, 3]}, "items": [{"id": "p_934", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_935", "content": "ipratropium bromide [SEP] Acute bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease.", "tokenized_content": [2, 27194, 12078, 2011, 2457, 13788, 3, 3939, 26272, 2287, 2564, 1927, 27194, 12078, 2011, 2457, 13788, 1930, 29629, 1922, 3724, 12234, 5352, 2573, 18, 3]}, "items": [{"id": "p_935", "content": "Ipratropium [SEP] A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is", "score": 1, "type": null, "tokenized_content": [2, 27194, 12078, 2011, 2457, 3, 43, 20318, 8151, 12171, 2712, 1942, 24031, 2308, 3868, 3311, 20404, 1930, 2253, 3655, 1958, 14728, 2485, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_936", "content": "theophylline [SEP] Acute bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease.", "tokenized_content": [2, 29629, 3, 3939, 26272, 2287, 2564, 1927, 27194, 12078, 2011, 2457, 13788, 1930, 29629, 1922, 3724, 12234, 5352, 2573, 18, 3]}, "items": [{"id": "p_936", "content": "Theophylline [SEP] A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous sys", "score": 1, "type": null, "tokenized_content": [2, 29629, 3, 43, 4963, 26059, 10533, 2037, 12459, 1956, 26829, 16, 6689, 3760, 7327, 2031, 16, 14700, 16470, 16, 4435, 1930, 4101, 7580, 7930, 1036, 3]}]}
{"query": {"id": "q_937", "content": "chronic obstructive pulmonary disease [SEP] nchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease.", "tokenized_content": [2, 3724, 12234, 5352, 2573, 3, 5301, 10647, 7408, 5148, 2104, 2564, 1927, 27194, 12078, 2011, 2457, 13788, 1930, 29629, 1922, 3724, 12234, 5352, 2573, 18, 3]}, "items": [{"id": "p_937", "content": "Pulmonary Disease, Chronic Obstructive [SEP] A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EM", "score": 1, "type": null, "tokenized_content": [2, 5352, 2573, 16, 3724, 12234, 3, 43, 2573, 1927, 3724, 9435, 14104, 22857, 10849, 18, 30117, 8427, 1927, 8714, 3951, 3724, 28938, 1930, 5352, 2391, 3]}]}
{"query": {"id": "q_938", "content": "ipratropium bromide [SEP] The bronchodilator effects of a single dose of ipratropium bromide aerosol (36 micrograms) and short-acting theophylline tablets (", "tokenized_content": [2, 27194, 12078, 2011, 2457, 13788, 3, 1920, 26272, 3061, 2564, 1927, 43, 2957, 3253, 1927, 27194, 12078, 2011, 2457, 13788, 16518, 12, 3480, 13362, 13, 1930, 3662, 17, 8290, 29629, 3]}, "items": [{"id": "p_938", "content": "Ipratropium [SEP] A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is", "score": 1, "type": null, "tokenized_content": [2, 27194, 12078, 2011, 2457, 3, 43, 20318, 8151, 12171, 2712, 1942, 24031, 2308, 3868, 3311, 20404, 1930, 2253, 3655, 1958, 14728, 2485, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_939", "content": "theophylline [SEP] of ipratropium bromide aerosol (36 micrograms) and short-acting theophylline tablets (dose titrated to produce serum levels of 10-20 microgr", "tokenized_content": [2, 29629, 3, 1927, 27194, 12078, 2011, 2457, 13788, 16518, 12, 3480, 13362, 13, 1930, 3662, 17, 8290, 29629, 16576, 12, 3253, 22861, 1942, 5074, 3256, 2428, 1927, 2119, 17, 2036, 3]}, "items": [{"id": "p_939", "content": "Theophylline [SEP] A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous sys", "score": 1, "type": null, "tokenized_content": [2, 29629, 3, 43, 4963, 26059, 10533, 2037, 12459, 1956, 26829, 16, 6689, 3760, 7327, 2031, 16, 14700, 16470, 16, 4435, 1930, 4101, 7580, 7930, 1036, 3]}]}
{"query": {"id": "q_940", "content": "chronic obstructive pulmonary disease [SEP]  placebo-controlled crossover study in 21 patients with stable, chronic obstructive pulmonary disease. Mean peak forced expiratory volume in 1 second (FEV1) increase", "tokenized_content": [2, 3724, 12234, 5352, 2573, 3, 5936, 17, 4642, 15845, 2161, 1922, 2900, 2132, 1956, 4700, 16, 3724, 12234, 5352, 2573, 18, 2667, 3833, 11653, 17655, 3776, 1922, 21, 2812, 12, 3]}, "items": [{"id": "p_940", "content": "Pulmonary Disease, Chronic Obstructive [SEP] A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EM", "score": 1, "type": null, "tokenized_content": [2, 5352, 2573, 16, 3724, 12234, 3, 43, 2573, 1927, 3724, 9435, 14104, 22857, 10849, 18, 30117, 8427, 1927, 8714, 3951, 3724, 28938, 1930, 5352, 2391, 3]}]}
{"query": {"id": "q_941", "content": "ipratropium [SEP] The bronchodilator effects of a single dose of ipratropium bromide aerosol (36 micrograms) and short-acting theophylline t", "tokenized_content": [2, 27194, 12078, 2011, 2457, 3, 1920, 26272, 3061, 2564, 1927, 43, 2957, 3253, 1927, 27194, 12078, 2011, 2457, 13788, 16518, 12, 3480, 13362, 13, 1930, 3662, 17, 8290, 29629, 62, 3]}, "items": [{"id": "p_941", "content": "Ipratropium [SEP] A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is", "score": 1, "type": null, "tokenized_content": [2, 27194, 12078, 2011, 2457, 3, 43, 20318, 8151, 12171, 2712, 1942, 24031, 2308, 3868, 3311, 20404, 1930, 2253, 3655, 1958, 14728, 2485, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_942", "content": "gastrointestinal systems [SEP] enced after theophylline use did involve the cardiovascular and gastrointestinal systems. These results show that ipratropium is a more potent bronchodi", "tokenized_content": [2, 8375, 3771, 3, 3350, 1919, 2256, 29629, 2485, 2811, 8156, 1920, 5321, 1930, 8375, 3771, 18, 2144, 2274, 2146, 1988, 27194, 12078, 2011, 2457, 1977, 43, 2253, 6828, 7777, 15799, 3]}, "items": [{"id": "p_942", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_943", "content": "chronic airflow obstruction [SEP] e potent bronchodilator than oral theophylline in patients with chronic airflow obstruction.", "tokenized_content": [2, 3724, 22857, 10849, 3, 47, 6828, 26272, 3061, 2254, 4726, 29629, 1922, 2132, 1956, 3724, 22857, 10849, 18, 3]}, "items": [{"id": "p_943", "content": "Pulmonary Disease, Chronic Obstructive [SEP] A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EM", "score": 1, "type": null, "tokenized_content": [2, 5352, 2573, 16, 3724, 12234, 3, 43, 2573, 1927, 3724, 9435, 14104, 22857, 10849, 18, 30117, 8427, 1927, 8714, 3951, 3724, 28938, 1930, 5352, 2391, 3]}]}
{"query": {"id": "q_944", "content": "nephropathy [SEP]  damage to the medullary interstitium in experimental analgesic nephropathy in F344 rats.", "tokenized_content": [2, 15582, 3, 4293, 1942, 1920, 19482, 10918, 11254, 1922, 3599, 14501, 15582, 1922, 14499, 6609, 3615, 18, 3]}, "items": [{"id": "p_944", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_945", "content": "Renal papillary necrosis [SEP] Renal papillary necrosis (RPN) and a decreased urinary concentrating ability developed d", "tokenized_content": [2, 4604, 15787, 7476, 3, 4604, 15787, 7476, 12, 4822, 1022, 13, 1930, 43, 3261, 7075, 2587, 2287, 3682, 3530, 46, 3]}, "items": [{"id": "p_945", "content": "Kidney Papillary Necrosis [SEP] A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this ar", "score": 1, "type": null, "tokenized_content": [2, 5245, 15787, 7476, 3, 43, 9388, 1927, 5245, 3902, 4378, 2007, 2024, 3539, 5884, 5245, 14668, 1019, 1922, 1920, 5245, 18755, 18, 22083, 1942, 2052, 2245, 3]}]}
{"query": {"id": "q_946", "content": "RPN [SEP] Renal papillary necrosis (RPN) and a decreased urinary concentrating ability developed during", "tokenized_content": [2, 4822, 1022, 3, 4604, 15787, 7476, 12, 4822, 1022, 13, 1930, 43, 3261, 7075, 2587, 2287, 3682, 3530, 2409, 3]}, "items": [{"id": "p_946", "content": "Kidney Papillary Necrosis [SEP] A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this ar", "score": 1, "type": null, "tokenized_content": [2, 5245, 15787, 7476, 3, 43, 9388, 1927, 5245, 3902, 4378, 2007, 2024, 3539, 5884, 5245, 14668, 1019, 1922, 1920, 5245, 18755, 18, 22083, 1942, 2052, 2245, 3]}]}
{"query": {"id": "q_947", "content": "aspirin [SEP] ng ability developed during continuous long-term treatment with aspirin and paracetamol in female Fischer 344 rats. Renal structure and", "tokenized_content": [2, 12396, 3, 4375, 3682, 3530, 2409, 4798, 2815, 17, 2576, 2311, 1956, 12396, 1930, 27021, 1922, 4232, 20113, 23473, 3615, 18, 4604, 3170, 1930, 3]}, "items": [{"id": "p_947", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_948", "content": "paracetamol [SEP] eveloped during continuous long-term treatment with aspirin and paracetamol in female Fischer 344 rats. Renal structure and concentrating a", "tokenized_content": [2, 27021, 3, 2180, 1938, 4907, 1007, 2409, 4798, 2815, 17, 2576, 2311, 1956, 12396, 1930, 27021, 1922, 4232, 20113, 23473, 3615, 18, 4604, 3170, 1930, 2587, 2287, 43, 3]}, "items": [{"id": "p_948", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_949", "content": "lithium [SEP] Less frequent lithium administration and lower urine volume.", "tokenized_content": [2, 14330, 3, 2941, 6439, 14330, 4183, 1930, 2826, 6960, 3776, 18, 3]}, "items": [{"id": "p_949", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_950", "content": "lithium [SEP] signed to determine whether patients maintained on a regimen of lithium on a once-per-day schedule have lower urine volumes than do pat", "tokenized_content": [2, 14330, 3, 13496, 1942, 3415, 3053, 2132, 5514, 1990, 43, 8607, 1927, 14330, 1990, 43, 5361, 17, 2079, 17, 3007, 11660, 2162, 2826, 6960, 8101, 2254, 2608, 2917, 3]}, "items": [{"id": "p_950", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_951", "content": "creatinine [SEP] were admitted to the hospital for measurement of lithium level, creatinine clearance, urine volume, and maximum osmolality. RESULTS: Multi", "tokenized_content": [2, 9374, 3, 1985, 9723, 1942, 1920, 3461, 1958, 4783, 1927, 14330, 2237, 16, 9374, 7802, 16, 6960, 3776, 16, 1930, 4419, 28854, 18, 2274, 30, 2779, 3]}, "items": [{"id": "p_951", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_952", "content": "Lithium [SEP] ing lithium once daily and/or by lowering the total daily dose. Lithium-induced polyuria seems to be related to extrarenal as well as t", "tokenized_content": [2, 14330, 3, 30393, 14330, 5361, 4692, 1930, 19, 2014, 2007, 11187, 1920, 2698, 4692, 3253, 18, 14330, 17, 2719, 4286, 8754, 6123, 1942, 1998, 2712, 1942, 8324, 2825, 1923, 1966, 3]}, "items": [{"id": "p_952", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_953", "content": "polyuria [SEP]  daily and/or by lowering the total daily dose. Lithium-induced polyuria seems to be related to extrarenal as well as to renal effects.", "tokenized_content": [2, 4286, 8754, 3, 4692, 1930, 19, 2014, 2007, 11187, 1920, 2698, 4692, 3253, 18, 14330, 17, 2719, 4286, 8754, 6123, 1942, 1998, 2712, 1942, 8324, 2825, 1923, 1966, 2486, 1966, 3]}, "items": [{"id": "p_953", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_954", "content": "adriamycin [SEP] Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissu", "tokenized_content": [2, 25622, 7898, 3, 2495, 1927, 25622, 7898, 4252, 1956, 4292, 3362, 21945, 1990, 2798, 1930, 2791, 2660, 1032, 3]}, "items": [{"id": "p_954", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_955", "content": "hyperthermia [SEP] Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues.", "tokenized_content": [2, 21945, 3, 2495, 1927, 25622, 7898, 4252, 1956, 4292, 3362, 21945, 1990, 2798, 1930, 2791, 3878, 18, 3]}, "items": [{"id": "p_955", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_956", "content": "tumor [SEP] Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues.", "tokenized_content": [2, 2798, 3, 2495, 1927, 25622, 7898, 4252, 1956, 4292, 3362, 21945, 1990, 2798, 1930, 2791, 3878, 18, 3]}, "items": [{"id": "p_956", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_957", "content": "Adriamycin [SEP] Thermal enhancement of Adriamycin-mediated antitumor activity and normal tissue toxicities by who", "tokenized_content": [2, 25622, 7898, 3, 7111, 7489, 1927, 25622, 7898, 17, 3434, 11775, 2455, 1930, 2791, 2960, 15251, 2007, 2746, 3]}, "items": [{"id": "p_957", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_958", "content": "toxicities [SEP] ent of Adriamycin-mediated antitumor activity and normal tissue toxicities by whole body hyperthermia were compared using a F344 rat model", "tokenized_content": [2, 15251, 3, 8496, 1927, 25622, 7898, 17, 3434, 11775, 2455, 1930, 2791, 2960, 15251, 2007, 4292, 3362, 21945, 1985, 2452, 2193, 43, 14499, 6609, 3067, 2322, 3]}, "items": [{"id": "p_958", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_959", "content": "hyperthermia [SEP] d antitumor activity and normal tissue toxicities by whole body hyperthermia were compared using a F344 rat model. Antitumor activity was st", "tokenized_content": [2, 21945, 3, 46, 11775, 2455, 1930, 2791, 2960, 15251, 2007, 4292, 3362, 21945, 1985, 2452, 2193, 43, 14499, 6609, 3067, 2322, 18, 11775, 2455, 1982, 1955, 3]}, "items": [{"id": "p_959", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_960", "content": "tumor [SEP] Thermal enhancement of Adriamycin-mediated antitumor activity and normal tissue toxicities by whole body hyperthermi", "tokenized_content": [2, 2798, 3, 7111, 7489, 1927, 25622, 7898, 17, 3434, 11775, 2455, 1930, 2791, 2960, 15251, 2007, 4292, 3362, 19144, 7395, 3]}, "items": [{"id": "p_960", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_961", "content": "leukopenia [SEP] tumor growth delay assay. Acute normal tissue toxicities (i.e., leukopenia and thrombocytopenia) and late normal tissue toxicities (i.e., ", "tokenized_content": [2, 5104, 12903, 3, 2798, 2905, 4989, 3381, 18, 3939, 2791, 2960, 15251, 12, 51, 18, 47, 18, 16, 5104, 12903, 1930, 17100, 13, 1930, 5058, 2791, 2960, 15251, 12, 51, 3]}, "items": [{"id": "p_961", "content": "Leukopenia [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5104, 12903, 3, 3]}]}
{"query": {"id": "q_962", "content": "thrombocytopenia [SEP] lay assay. Acute normal tissue toxicities (i.e., leukopenia and thrombocytopenia) and late normal tissue toxicities (i.e., myocardial and kidney", "tokenized_content": [2, 17100, 3, 4000, 3381, 18, 3939, 2791, 2960, 15251, 12, 51, 18, 47, 18, 16, 5104, 12903, 1930, 17100, 13, 1930, 5058, 2791, 2960, 15251, 12, 51, 18, 47, 18, 3]}, "items": [{"id": "p_962", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_963", "content": "kidney injury [SEP] openia) and late normal tissue toxicities (i.e., myocardial and kidney injury) were evaluated by functional/physiological assays and by morph", "tokenized_content": [2, 5245, 4047, 3, 4437, 2126, 13, 1930, 5058, 2791, 2960, 15251, 12, 51, 18, 47, 18, 16, 6497, 1930, 5245, 4047, 13, 1985, 3747, 2007, 3183, 19, 5005, 4614, 1930, 3]}, "items": [{"id": "p_963", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_964", "content": "renal lesions [SEP] estimated for \"late\" damage (based on morphological cardiac and renal lesions) varied between 2.4 and 4.3. Thus, while whole body hyperthermi", "tokenized_content": [2, 4604, 4518, 3, 4185, 1958, 6, 5058, 6, 4293, 12, 2454, 1990, 7060, 4435, 1930, 4604, 4518, 13, 6760, 2192, 22, 18, 24, 1930, 24, 18, 23, 18, 2842, 16, 3]}, "items": [{"id": "p_964", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_965", "content": "toxicity [SEP] ia enhances Adriamycin-mediated antitumor effect, normal tissue toxicity is also increased, and the potential therapeutic gain of the co", "tokenized_content": [2, 5532, 3, 11640, 9515, 25622, 7898, 17, 3434, 11775, 2495, 16, 2791, 2960, 5532, 1977, 2222, 2502, 16, 1930, 1920, 2889, 4272, 5938, 1927, 1920, 2081, 3]}, "items": [{"id": "p_965", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_966", "content": "Prazosin [SEP] Prazosin-induced stress incontinence.", "tokenized_content": [2, 29041, 5872, 3, 29041, 5872, 17, 2719, 3071, 16783, 18, 3]}, "items": [{"id": "p_966", "content": "Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS", "score": 1, "type": null, "tokenized_content": [2, 29041, 5872, 3, 43, 5328, 13672, 4595, 17, 21, 8151, 2251, 1922, 1920, 2311, 1927, 4003, 4574, 31, 5579, 31, 30004, 26493, 31, 6451, 2175, 2009, 2445, 1934, 3]}]}
{"query": {"id": "q_967", "content": "stress incontinence [SEP] Prazosin-induced stress incontinence.", "tokenized_content": [2, 3071, 16783, 3, 29041, 5872, 17, 2719, 3071, 16783, 18, 3]}, "items": [{"id": "p_967", "content": "Urinary Incontinence, Stress [SEP] Involuntary discharge of URINE as a result of physical activities that increase abdominal pressure on the URINARY BLADDER withou", "score": 1, "type": null, "tokenized_content": [2, 7075, 16783, 16, 3071, 3, 28493, 7695, 1927, 6960, 1966, 43, 3211, 1927, 3841, 4209, 1988, 2760, 6900, 3772, 1990, 1920, 7075, 7821, 1956, 4468, 3]}]}
{"query": {"id": "q_968", "content": "stress incontinence [SEP] A case of genuine stress incontinence due to prazosin, a common antihypertensive drug, is presented. ", "tokenized_content": [2, 3071, 16783, 3, 43, 3087, 1927, 26336, 3071, 16783, 2810, 1942, 29041, 5872, 16, 43, 3059, 16439, 2838, 16, 1977, 3549, 18, 3]}, "items": [{"id": "p_968", "content": "Urinary Incontinence, Stress [SEP] Involuntary discharge of URINE as a result of physical activities that increase abdominal pressure on the URINARY BLADDER withou", "score": 1, "type": null, "tokenized_content": [2, 7075, 16783, 16, 3071, 3, 28493, 7695, 1927, 6960, 1966, 43, 3211, 1927, 3841, 4209, 1988, 2760, 6900, 3772, 1990, 1920, 7075, 7821, 1956, 4468, 3]}]}
{"query": {"id": "q_969", "content": "prazosin [SEP] A case of genuine stress incontinence due to prazosin, a common antihypertensive drug, is presented. Prazosin exerts ", "tokenized_content": [2, 29041, 5872, 3, 43, 3087, 1927, 26336, 3071, 16783, 2810, 1942, 29041, 5872, 16, 43, 3059, 16439, 2838, 16, 1977, 3549, 18, 29041, 5872, 14235, 3]}, "items": [{"id": "p_969", "content": "Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS", "score": 1, "type": null, "tokenized_content": [2, 29041, 5872, 3, 43, 5328, 13672, 4595, 17, 21, 8151, 2251, 1922, 1920, 2311, 1927, 4003, 4574, 31, 5579, 31, 30004, 26493, 31, 6451, 2175, 2009, 2445, 1934, 3]}]}
{"query": {"id": "q_970", "content": "Prazosin [SEP]  due to prazosin, a common antihypertensive drug, is presented. Prazosin exerts its antihypertensive effects through vasodilatation caus", "tokenized_content": [2, 29041, 5872, 3, 2810, 1942, 29041, 5872, 16, 43, 3059, 16439, 2838, 16, 1977, 3549, 18, 29041, 5872, 14235, 2496, 16439, 2564, 2596, 13662, 15395, 3092, 3]}, "items": [{"id": "p_970", "content": "Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS", "score": 1, "type": null, "tokenized_content": [2, 29041, 5872, 3, 43, 5328, 13672, 4595, 17, 21, 8151, 2251, 1922, 1920, 2311, 1927, 4003, 4574, 31, 5579, 31, 30004, 26493, 31, 6451, 2175, 2009, 2445, 1934, 3]}]}
{"query": {"id": "q_971", "content": "verapamil [SEP] c studies while on prazosin and subsequent studies while taking verapamil. Her incontinence resolved with the change of medication. The r", "tokenized_content": [2, 23300, 3, 45, 2351, 2679, 1990, 29041, 5872, 1930, 4521, 2351, 2679, 6303, 23300, 18, 3656, 16783, 8397, 1956, 1920, 3185, 1927, 6093, 18, 1920, 60, 3]}, "items": [{"id": "p_971", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_972", "content": "incontinence [SEP] A case of genuine stress incontinence due to prazosin, a common antihypertensive drug, is presented. ", "tokenized_content": [2, 16783, 3, 43, 3087, 1927, 26336, 3071, 16783, 2810, 1942, 29041, 5872, 16, 43, 3059, 16439, 2838, 16, 1977, 3549, 18, 3]}, "items": [{"id": "p_972", "content": "Urinary Incontinence [SEP] Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types o", "score": 1, "type": null, "tokenized_content": [2, 7075, 16783, 3, 28493, 3257, 1927, 6960, 16, 2427, 1966, 9186, 1941, 1927, 6960, 18, 2176, 1977, 43, 3226, 1927, 3425, 5030, 6598, 4028, 18, 3044, 3584, 57, 3]}]}
{"query": {"id": "q_973", "content": "Myocardial infarction [SEP] Myocardial infarction following sublingual administration of isosorbide dinitrate.", "tokenized_content": [2, 6497, 8358, 3, 6497, 8358, 2894, 20764, 16800, 4183, 1927, 4911, 2204, 16007, 2261, 11687, 26813, 18, 3]}, "items": [{"id": "p_973", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_974", "content": "isosorbide dinitrate [SEP] Myocardial infarction following sublingual administration of isosorbide dinitrate.", "tokenized_content": [2, 4911, 2204, 16007, 2261, 11687, 26813, 3, 6497, 8358, 2894, 20764, 16800, 4183, 1927, 4911, 2204, 16007, 2261, 11687, 26813, 18, 3]}, "items": [{"id": "p_974", "content": "Isosorbide Dinitrate [SEP] A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of acti", "score": 1, "type": null, "tokenized_content": [2, 4911, 2204, 16007, 2261, 11687, 26813, 3, 43, 28194, 2251, 1922, 1920, 2311, 1927, 16961, 23540, 1937, 18, 2496, 7728, 2032, 2551, 1942, 8686, 14966, 1921, 2308, 1956, 43, 10353, 4727, 1927, 4033, 1033, 3]}]}
{"query": {"id": "q_975", "content": "necrosis [SEP] A 78-year-old with healed septal necrosis suffered a recurrent myocardial infarction of the anterior wall", "tokenized_content": [2, 7476, 3, 43, 5440, 17, 2476, 17, 4156, 1956, 25515, 16458, 7476, 13949, 43, 7457, 6497, 8358, 1927, 1920, 5477, 4821, 3]}, "items": [{"id": "p_975", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_976", "content": "myocardial infarction [SEP] A 78-year-old with healed septal necrosis suffered a recurrent myocardial infarction of the anterior wall following the administration of isosorbide", "tokenized_content": [2, 6497, 8358, 3, 43, 5440, 17, 2476, 17, 4156, 1956, 25515, 16458, 7476, 13949, 43, 7457, 6497, 8358, 1927, 1920, 5477, 4821, 2894, 1920, 4183, 1927, 4911, 2204, 16007, 2261, 3]}, "items": [{"id": "p_976", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_977", "content": "isosorbide dinitrate [SEP] infarction of the anterior wall following the administration of isosorbide dinitrate 5 mg sublingually. After detailing the course of events, we dis", "tokenized_content": [2, 4911, 2204, 16007, 2261, 11687, 26813, 3, 8358, 1927, 1920, 5477, 4821, 2894, 1920, 4183, 1927, 4911, 2204, 16007, 2261, 11687, 26813, 25, 2786, 20764, 16800, 1954, 18, 2256, 3966, 3]}, "items": [{"id": "p_977", "content": "Isosorbide Dinitrate [SEP] A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of acti", "score": 1, "type": null, "tokenized_content": [2, 4911, 2204, 16007, 2261, 11687, 26813, 3, 43, 28194, 2251, 1922, 1920, 2311, 1927, 16961, 23540, 1937, 18, 2496, 7728, 2032, 2551, 1942, 8686, 14966, 1921, 2308, 1956, 43, 10353, 4727, 1927, 4033, 1033, 3]}]}
{"query": {"id": "q_978", "content": "spasm [SEP] e course of events, we discuss the role of paradoxical coronary spasm and hypotension-mediated myocardial ischemia occurring downstre", "tokenized_content": [2, 24431, 3, 47, 4914, 1927, 3916, 16, 2038, 3891, 1920, 2770, 1927, 24242, 5846, 24431, 1930, 16453, 17, 3434, 6497, 7716, 6966, 26355, 4265, 3]}, "items": [{"id": "p_978", "content": "Spasm [SEP] An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24431, 3, 1925, 28493, 8332, 1927, 43, 3760, 2014, 2210, 1927, 7848, 18, 24431, 1036, 2278, 8156, 7345, 3760, 2014, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_979", "content": "hypotension [SEP] f events, we discuss the role of paradoxical coronary spasm and hypotension-mediated myocardial ischemia occurring downstream to significan", "tokenized_content": [2, 16453, 3, 48, 3916, 16, 2038, 3891, 1920, 2770, 1927, 24242, 5846, 24431, 1930, 16453, 17, 3434, 6497, 7716, 6966, 5863, 1942, 2208, 1928, 3]}, "items": [{"id": "p_979", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_980", "content": "myocardial ischemia [SEP] the role of paradoxical coronary spasm and hypotension-mediated myocardial ischemia occurring downstream to significant coronary arterial stenosis ", "tokenized_content": [2, 6497, 7716, 3, 1920, 2770, 1927, 24242, 5846, 24431, 1930, 16453, 17, 3434, 6497, 7716, 6966, 5863, 1942, 2228, 5846, 6624, 10407, 3]}, "items": [{"id": "p_980", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_981", "content": "coronary arterial stenosis [SEP] ediated myocardial ischemia occurring downstream to significant coronary arterial stenosis in the pathophysiology of acute coronary insufficiency.", "tokenized_content": [2, 5846, 6624, 10407, 3, 3347, 23682, 6497, 7716, 6966, 5863, 1942, 2228, 5846, 6624, 10407, 1922, 1920, 11985, 1927, 3939, 5846, 14566, 18, 3]}, "items": [{"id": "p_981", "content": "Coronary Stenosis [SEP] Narrowing or constriction of a coronary artery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 10407, 3, 21005, 2014, 19837, 1927, 43, 5846, 5511, 18, 3]}]}
{"query": {"id": "q_982", "content": "acute coronary insufficiency [SEP] ignificant coronary arterial stenosis in the pathophysiology of acute coronary insufficiency.", "tokenized_content": [2, 3939, 5846, 14566, 3, 12046, 2077, 2031, 5846, 6624, 10407, 1922, 1920, 11985, 1927, 3939, 5846, 14566, 18, 3]}, "items": [{"id": "p_982", "content": "Acute Coronary Syndrome [SEP] An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCA", "score": 1, "type": null, "tokenized_content": [2, 3939, 5846, 4741, 3, 1925, 11631, 1927, 6497, 7716, 1988, 4933, 4691, 1036, 4872, 2254, 43, 6809, 16961, 1024, 11631, 1988, 8676, 2278, 2949, 1942, 15924, 3375, 3]}]}
{"query": {"id": "q_983", "content": "Fluoxetine [SEP] Fluoxetine-induced akathisia: clinical and theoretical implications.", "tokenized_content": [2, 22176, 3, 22176, 17, 2719, 4464, 2183, 1937, 2126, 30, 2535, 1930, 7768, 7020, 18, 3]}, "items": [{"id": "p_983", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_984", "content": "akathisia [SEP] Fluoxetine-induced akathisia: clinical and theoretical implications.", "tokenized_content": [2, 4464, 2183, 1937, 2126, 3, 22176, 17, 2719, 4464, 2183, 1937, 2126, 30, 2535, 1930, 7768, 7020, 18, 3]}, "items": [{"id": "p_984", "content": "Akathisia, Drug-Induced [SEP] A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often de", "score": 1, "type": null, "tokenized_content": [2, 4464, 2183, 1937, 2126, 16, 2838, 17, 2719, 3, 43, 2625, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 1930, 4378, 2007, 1925, 4495, 7534, 1927, 4842, 6172, 26481, 3868, 2028, 3]}]}
{"query": {"id": "q_985", "content": "fluoxetine [SEP] Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major dep", "tokenized_content": [2, 22176, 3, 3628, 2132, 5962, 22176, 1958, 1920, 2311, 1927, 25555, 21543, 4770, 2014, 3044, 2554, 3]}, "items": [{"id": "p_985", "content": "Fluoxetine [SEP] The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effec", "score": 1, "type": null, "tokenized_content": [2, 22176, 3, 1920, 2561, 3626, 2487, 11153, 5047, 4106, 18, 2176, 1977, 2251, 1966, 1925, 14183, 1930, 3868, 2258, 43, 2253, 9630, 4159, 17, 2121, 1940, 3]}]}
{"query": {"id": "q_986", "content": "obsessive compulsive disorder [SEP] Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia. The typical fluoxetine", "tokenized_content": [2, 25555, 21543, 4770, 3, 3628, 2132, 5962, 22176, 1958, 1920, 2311, 1927, 25555, 21543, 4770, 2014, 3044, 4621, 3530, 4464, 2183, 1937, 2126, 18, 1920, 5939, 22176, 3]}, "items": [{"id": "p_986", "content": "Obsessive-Compulsive Disorder [SEP] An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, though", "score": 1, "type": null, "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 1925, 5592, 4770, 4378, 2007, 7457, 16, 7733, 2339, 6744, 2014, 2059, 19389, 18, 2339, 6744, 2032, 1920, 2738, 7556, 15479, 16, 4170, 3]}]}
{"query": {"id": "q_987", "content": "major depression [SEP] luoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia. The typical fluoxetine-induced symptoms of", "tokenized_content": [2, 3044, 4621, 3, 28327, 1039, 15387, 1958, 1920, 2311, 1927, 25555, 21543, 4770, 2014, 3044, 4621, 3530, 4464, 2183, 1937, 2126, 18, 1920, 5939, 22176, 17, 2719, 3601, 1927, 3]}, "items": [{"id": "p_987", "content": "Depressive Disorder, Major [SEP] Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.\n  ", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 16, 3044, 3, 4961, 4621, 16905, 1922, 1920, 2755, 2306, 3047, 1930, 4378, 2007, 27013, 16, 2723, 3910, 16, 26124, 26822, 1019, 16, 1930, 18389, 18, 3]}]}
{"query": {"id": "q_988", "content": "akathisia [SEP]  of obsessive compulsive disorder or major depression developed akathisia. The typical fluoxetine-induced symptoms of restlessness, const", "tokenized_content": [2, 4464, 2183, 1937, 2126, 3, 1927, 25555, 21543, 4770, 2014, 3044, 4621, 3530, 4464, 2183, 1937, 2126, 18, 1920, 5939, 22176, 17, 2719, 3601, 1927, 6172, 26481, 16, 4713, 3]}, "items": [{"id": "p_988", "content": "Akathisia, Drug-Induced [SEP] A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often de", "score": 1, "type": null, "tokenized_content": [2, 4464, 2183, 1937, 2126, 16, 2838, 17, 2719, 3, 43, 2625, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 1930, 4378, 2007, 1925, 4495, 7534, 1927, 4842, 6172, 26481, 3868, 2028, 3]}]}
{"query": {"id": "q_989", "content": "anxiety [SEP]  pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathi", "tokenized_content": [2, 5592, 3, 17248, 16, 5120, 5427, 8264, 1927, 1920, 18071, 1930, 16689, 16, 1930, 4961, 5592, 1985, 16586, 2037, 2690, 1927, 20325, 17920, 17, 2719, 4464, 2183, 1033, 3]}, "items": [{"id": "p_989", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_990", "content": "Akathisia [SEP] ine-induced akathisia were identical, although somewhat milder. Akathisia appeared to be a common side effect of fluoxetine and generally", "tokenized_content": [2, 4464, 2183, 1937, 2126, 3, 11116, 17, 2719, 4464, 2183, 1937, 2126, 1985, 6119, 16, 2876, 9786, 23273, 18, 4464, 2183, 1937, 2126, 6209, 1942, 1998, 43, 3059, 4159, 2495, 3]}, "items": [{"id": "p_990", "content": "Akathisia, Drug-Induced [SEP] A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often de", "score": 1, "type": null, "tokenized_content": [2, 4464, 2183, 1937, 2126, 16, 2838, 17, 2719, 3, 43, 2625, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 1930, 4378, 2007, 1925, 4495, 7534, 1927, 4842, 6172, 26481, 3868, 2028, 3]}]}
{"query": {"id": "q_991", "content": "propranolol [SEP] responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both. The authors suggest that fluoxetine-i", "tokenized_content": [2, 21395, 3, 10711, 2486, 1942, 2311, 1956, 1920, 4666, 17, 13672, 8151, 21395, 16, 3253, 3378, 16, 2014, 2321, 18, 1920, 3875, 3220, 1988, 22176, 17, 51, 3]}, "items": [{"id": "p_991", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_992", "content": "antidepressant [SEP] e pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced \"jitteriness\" may be identical.", "tokenized_content": [2, 14183, 3, 47, 11985, 1927, 22176, 17, 2719, 4464, 2183, 1937, 2126, 1930, 12258, 13153, 14183, 17, 2719, 6, 14280, 3519, 16654, 1979, 6, 2278, 1998, 6119, 18, 3]}, "items": [{"id": "p_992", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_993", "content": "Chronic active hepatitis [SEP] Chronic active hepatitis associated with diclofenac sodium therapy.", "tokenized_content": [2, 3724, 3500, 7977, 3, 3724, 3500, 7977, 2458, 1956, 27304, 5227, 3181, 18, 3]}, "items": [{"id": "p_993", "content": "Hepatitis, Chronic [SEP] INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and ", "score": 1, "type": null, "tokenized_content": [2, 7977, 16, 3724, 3, 4531, 1927, 1920, 3568, 1956, 8234, 12457, 4047, 1958, 26, 3221, 2014, 2253, 16, 4378, 2007, 7476, 1927, 9919, 1930, 3]}]}
{"query": {"id": "q_994", "content": "diclofenac sodium [SEP] Chronic active hepatitis associated with diclofenac sodium therapy.", "tokenized_content": [2, 27304, 5227, 3, 3724, 3500, 7977, 2458, 1956, 27304, 5227, 3181, 18, 3]}, "items": [{"id": "p_994", "content": "Diclofenac [SEP] A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium ", "score": 1, "type": null, "tokenized_content": [2, 27304, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1956, 2246, 18425, 3023, 1930, 14501, 7728, 18, 2176, 1977, 5985, 3322, 1966, 1920, 5227, 3]}]}
{"query": {"id": "q_995", "content": "Diclofenac sodium [SEP] Diclofenac sodium (Voltarol, Geigy Pharmaceuticals) is a non-steroidal anti-infla", "tokenized_content": [2, 27304, 5227, 3, 27304, 5227, 12, 6375, 15742, 1024, 16, 3929, 1950, 1012, 15985, 13, 1977, 43, 2447, 17, 24932, 2246, 17, 2552, 1019, 3]}, "items": [{"id": "p_995", "content": "Diclofenac [SEP] A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium ", "score": 1, "type": null, "tokenized_content": [2, 27304, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1956, 2246, 18425, 3023, 1930, 14501, 7728, 18, 2176, 1977, 5985, 3322, 1966, 1920, 5227, 3]}]}
{"query": {"id": "q_996", "content": "Voltarol [SEP] Diclofenac sodium (Voltarol, Geigy Pharmaceuticals) is a non-steroidal anti-inflammatory de", "tokenized_content": [2, 6375, 15742, 1024, 3, 27304, 5227, 12, 6375, 15742, 1024, 16, 3929, 1950, 1012, 15985, 13, 1977, 43, 2447, 17, 24932, 2246, 17, 3769, 2028, 3]}, "items": [{"id": "p_996", "content": "Diclofenac [SEP] A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium ", "score": 1, "type": null, "tokenized_content": [2, 27304, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1956, 2246, 18425, 3023, 1930, 14501, 7728, 18, 2176, 1977, 5985, 3322, 1966, 1920, 5227, 3]}]}
{"query": {"id": "q_997", "content": "phenylacetic acid [SEP] maceuticals) is a non-steroidal anti-inflammatory derivative of phenylacetic acid. Although generally well-tolerated, asymptomatic abnormalities ", "tokenized_content": [2, 7971, 13722, 2687, 3, 26158, 1984, 2046, 1036, 13, 1977, 43, 2447, 17, 24932, 2246, 17, 3769, 10533, 1927, 7971, 13722, 2687, 18, 2876, 4933, 2486, 17, 11117, 16, 9978, 3]}, "items": [{"id": "p_997", "content": "phenylacetic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7971, 13722, 2687, 3, 3]}]}
{"query": {"id": "q_998", "content": "abnormalities of liver function [SEP] nylacetic acid. Although generally well-tolerated, asymptomatic abnormalities of liver function have been recorded and, less commonly, severe hepatitis induced", "tokenized_content": [2, 6754, 1927, 3568, 2347, 3, 8932, 5148, 1972, 2002, 2687, 18, 2876, 4933, 2486, 17, 11117, 16, 9978, 6754, 1927, 3568, 2347, 2162, 2252, 4562, 1930, 16, 2941, 5384, 16, 3]}, "items": [{"id": "p_998", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_999", "content": "hepatitis [SEP] of liver function have been recorded and, less commonly, severe hepatitis induced by diclofenac. The patient described developed chronic ", "tokenized_content": [2, 7977, 3, 1927, 3568, 2347, 2162, 2252, 4562, 1930, 16, 2941, 5384, 16, 4010, 7977, 2719, 2007, 27304, 18, 1920, 2774, 2910, 3530, 3724, 3]}, "items": [{"id": "p_999", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1000", "content": "diclofenac [SEP] e been recorded and, less commonly, severe hepatitis induced by diclofenac. The patient described developed chronic active hepatitis after", "tokenized_content": [2, 27304, 3, 47, 2252, 4562, 1930, 16, 2941, 5384, 16, 4010, 7977, 2719, 2007, 27304, 18, 1920, 2774, 2910, 3530, 3724, 3500, 7977, 2256, 3]}, "items": [{"id": "p_1000", "content": "Diclofenac [SEP] A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium ", "score": 1, "type": null, "tokenized_content": [2, 27304, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1956, 2246, 18425, 3023, 1930, 14501, 7728, 18, 2176, 1977, 5985, 3322, 1966, 1920, 5227, 3]}]}
{"query": {"id": "q_1001", "content": "chronic active hepatitis [SEP] epatitis induced by diclofenac. The patient described developed chronic active hepatitis after six months therapy with diclofenac sodium which progresse", "tokenized_content": [2, 3724, 3500, 7977, 3, 15369, 11648, 2719, 2007, 27304, 18, 1920, 2774, 2910, 3530, 3724, 3500, 7977, 2256, 3798, 3221, 3181, 1956, 27304, 5227, 2154, 4782, 1021, 3]}, "items": [{"id": "p_1001", "content": "Hepatitis, Chronic [SEP] INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and ", "score": 1, "type": null, "tokenized_content": [2, 7977, 16, 3724, 3, 4531, 1927, 1920, 3568, 1956, 8234, 12457, 4047, 1958, 26, 3221, 2014, 2253, 16, 4378, 2007, 7476, 1927, 9919, 1930, 3]}]}
{"query": {"id": "q_1002", "content": "diclofenac sodium [SEP] eveloped chronic active hepatitis after six months therapy with diclofenac sodium which progressed despite the withdrawal of the drug, a finding ", "tokenized_content": [2, 27304, 5227, 3, 2180, 1938, 4907, 1007, 3724, 3500, 7977, 2256, 3798, 3221, 3181, 1956, 27304, 5227, 2154, 15942, 4281, 1920, 9594, 1927, 1920, 2838, 16, 43, 2849, 3]}, "items": [{"id": "p_1002", "content": "Diclofenac [SEP] A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium ", "score": 1, "type": null, "tokenized_content": [2, 27304, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1956, 2246, 18425, 3023, 1930, 14501, 7728, 18, 2176, 1977, 5985, 3322, 1966, 1920, 5227, 3]}]}
{"query": {"id": "q_1003", "content": "Stroke [SEP] Stroke associated with cocaine use.", "tokenized_content": [2, 5235, 3, 5235, 2458, 1956, 9045, 2485, 18, 3]}, "items": [{"id": "p_1003", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_1004", "content": "cocaine [SEP] Stroke associated with cocaine use.", "tokenized_content": [2, 9045, 3, 5235, 2458, 1956, 9045, 2485, 18, 3]}, "items": [{"id": "p_1004", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1005", "content": "cocaine [SEP] We describe eight patients in whom cocaine use was related to stroke and review 39 cases from the literatu", "tokenized_content": [2, 9045, 3, 2038, 5993, 5066, 2132, 1922, 8566, 9045, 2485, 1982, 2712, 1942, 5235, 1930, 3043, 3886, 2919, 2037, 1920, 4154, 1926, 1032, 3]}, "items": [{"id": "p_1005", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1006", "content": "stroke [SEP] We describe eight patients in whom cocaine use was related to stroke and review 39 cases from the literature. Among these 47 patient", "tokenized_content": [2, 5235, 3, 2038, 5993, 5066, 2132, 1922, 8566, 9045, 2485, 1982, 2712, 1942, 5235, 1930, 3043, 3886, 2919, 2037, 1920, 4431, 18, 2706, 2144, 4261, 2774, 3]}, "items": [{"id": "p_1006", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_1007", "content": "Stroke [SEP] ean (+/- SD) age was 32.5 +/- 12.1 years; 76% (34/45) were men. Stroke followed cocaine use by inhalation, intranasal, intravenous, an", "tokenized_content": [2, 5235, 3, 11377, 1022, 12, 15, 19, 17, 4035, 13, 2632, 1982, 3323, 18, 25, 15, 19, 17, 2369, 18, 21, 2739, 31, 5439, 9, 12, 3540, 19, 3607, 13, 3]}, "items": [{"id": "p_1007", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_1008", "content": "Intracranial aneurysms [SEP]  inhalation, intranasal, intravenous, and intramuscular routes. Intracranial aneurysms or arteriovenous malformations were present in 17 of 32 patient", "tokenized_content": [2, 12179, 16673, 3, 14728, 16, 21418, 16, 7307, 16, 1930, 16774, 14057, 18, 12179, 16673, 2014, 27468, 17360, 1985, 2481, 1922, 2752, 1927, 3323, 2774, 3]}, "items": [{"id": "p_1008", "content": "Intracranial Aneurysm [SEP] Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch", "score": 1, "type": null, "tokenized_content": [2, 12179, 13373, 3, 4552, 2397, 7056, 16908, 2029, 1922, 1920, 4821, 1927, 12179, 2877, 7208, 18, 2501, 3059, 2032, 1920, 12988, 2168, 12, 28195, 13, 16673, 4810, 2019, 6089, 3]}]}
{"query": {"id": "q_1009", "content": "arteriovenous malformations [SEP] ntravenous, and intramuscular routes. Intracranial aneurysms or arteriovenous malformations were present in 17 of 32 patients studied angiographically or a", "tokenized_content": [2, 27468, 17360, 3, 20517, 7921, 11873, 1957, 16, 1930, 16774, 14057, 18, 12179, 16673, 2014, 27468, 17360, 1985, 2481, 1922, 2752, 1927, 3323, 2132, 3942, 22626, 2169, 2014, 43, 3]}, "items": [{"id": "p_1009", "content": "Arteriovenous Malformations [SEP] Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They ", "score": 1, "type": null, "tokenized_content": [2, 27468, 17360, 3, 4552, 3337, 1927, 2877, 7208, 1988, 17157, 6624, 2877, 4103, 2460, 14785, 2979, 16371, 2596, 1920, 16973, 18, 2611, 3]}]}
{"query": {"id": "q_1010", "content": "cerebral vasculitis [SEP] nt in 17 of 32 patients studied angiographically or at autopsy; cerebral vasculitis was present in two patients. Cerebral infarction occurred in 10", "tokenized_content": [2, 6329, 21548, 3, 5891, 1922, 2752, 1927, 3323, 2132, 3942, 22626, 2169, 2014, 2019, 16740, 31, 6329, 21548, 1982, 2481, 1922, 2288, 2132, 18, 6329, 8358, 4807, 1922, 2119, 3]}, "items": [{"id": "p_1010", "content": "Vasculitis, Central Nervous System [SEP] Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathi", "score": 1, "type": null, "tokenized_content": [2, 21548, 16, 4101, 7580, 2433, 3, 4531, 1927, 2877, 7208, 2651, 1920, 4101, 7580, 2433, 18, 3065, 21548, 1977, 5394, 4189, 2007, 8904, 2014, 11407, 4290, 1033, 3]}]}
{"query": {"id": "q_1011", "content": "Cerebral infarction [SEP] or at autopsy; cerebral vasculitis was present in two patients. Cerebral infarction occurred in 10 patients (22%), intracerebral hemorrhage in 22 (", "tokenized_content": [2, 6329, 8358, 3, 2014, 2019, 16740, 31, 6329, 21548, 1982, 2481, 1922, 2288, 2132, 18, 6329, 8358, 4807, 1922, 2119, 2132, 12, 2950, 9, 13, 16, 24152, 10489, 1922, 2950, 3]}, "items": [{"id": "p_1011", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_1012", "content": "intracerebral hemorrhage [SEP] wo patients. Cerebral infarction occurred in 10 patients (22%), intracerebral hemorrhage in 22 (49%), and subarachnoid hemorrhage in 13 (29%). These dat", "tokenized_content": [2, 24152, 10489, 3, 26334, 2132, 18, 6329, 8358, 4807, 1922, 2119, 2132, 12, 2950, 9, 13, 16, 24152, 10489, 1922, 2950, 12, 4343, 9, 13, 16, 1930, 23795, 10489, 1922, 3]}, "items": [{"id": "p_1012", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_1013", "content": "subarachnoid hemorrhage [SEP] in 10 patients (22%), intracerebral hemorrhage in 22 (49%), and subarachnoid hemorrhage in 13 (29%). These data indicate that (1) the apparent incidenc", "tokenized_content": [2, 23795, 10489, 3, 1922, 2119, 2132, 12, 2950, 9, 13, 16, 24152, 10489, 1922, 2950, 12, 4343, 9, 13, 16, 1930, 23795, 10489, 1922, 2590, 12, 3230, 9, 13, 18, 3]}, "items": [{"id": "p_1013", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_1014", "content": "intracranial aneurysms [SEP] ion; (4) stroke after cocaine use is frequently associated with intracranial aneurysms and arteriovenous malformations; and (5) in cocaine-associated ", "tokenized_content": [2, 12179, 16673, 3, 4755, 31, 12, 24, 13, 5235, 2256, 9045, 2485, 1977, 5467, 2458, 1956, 12179, 16673, 1930, 27468, 17360, 31, 1930, 12, 25, 13, 1922, 9045, 17, 2458, 3]}, "items": [{"id": "p_1014", "content": "Intracranial Aneurysm [SEP] Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch", "score": 1, "type": null, "tokenized_content": [2, 12179, 13373, 3, 4552, 2397, 7056, 16908, 2029, 1922, 1920, 4821, 1927, 12179, 2877, 7208, 18, 2501, 3059, 2032, 1920, 12988, 2168, 12, 28195, 13, 16673, 4810, 2019, 6089, 3]}]}
{"query": {"id": "q_1015", "content": "intracranial hemorrhage [SEP] mations; and (5) in cocaine-associated stroke, the frequency of intracranial hemorrhage exceeds that of cerebral infarction.", "tokenized_content": [2, 12179, 10489, 3, 2888, 2443, 31, 1930, 12, 25, 13, 1922, 9045, 17, 2458, 5235, 16, 1920, 3528, 1927, 12179, 10489, 18216, 1988, 1927, 6329, 8358, 18, 3]}, "items": [{"id": "p_1015", "content": "Intracranial Hemorrhages [SEP] Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often lea", "score": 1, "type": null, "tokenized_content": [2, 12179, 10489, 1036, 3, 7633, 2651, 1920, 13682, 16, 2710, 10489, 1036, 1922, 1920, 3068, 1930, 1920, 2559, 5726, 1927, 10286, 1918, 18, 1920, 11781, 1927, 2877, 3868, 2071, 1019, 3]}]}
{"query": {"id": "q_1016", "content": "cerebral infarction [SEP] troke, the frequency of intracranial hemorrhage exceeds that of cerebral infarction.", "tokenized_content": [2, 6329, 8358, 3, 12730, 3324, 16, 1920, 3528, 1927, 12179, 10489, 18216, 1988, 1927, 6329, 8358, 18, 3]}, "items": [{"id": "p_1016", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_1017", "content": "Glyburide [SEP] Glyburide-induced hepatitis.", "tokenized_content": [2, 3376, 13789, 2261, 3, 3376, 13789, 2261, 17, 2719, 7977, 18, 3]}, "items": [{"id": "p_1017", "content": "Glyburide [SEP] An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3376, 13789, 2261, 3, 1925, 26818, 26496, 16648, 10533, 1956, 7728, 2551, 1942, 2690, 1927, 4891, 20194, 5482, 18, 3]}]}
{"query": {"id": "q_1018", "content": "hepatitis [SEP] Glyburide-induced hepatitis.", "tokenized_content": [2, 7977, 3, 3376, 13789, 2261, 17, 2719, 7977, 18, 3]}, "items": [{"id": "p_1018", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1019", "content": "hepatotoxicity [SEP] Drug-induced hepatotoxicity, although common, has been reported only infrequently with sulf", "tokenized_content": [2, 24126, 3, 2838, 17, 2719, 24126, 16, 2876, 3059, 16, 2258, 2252, 2568, 2444, 28177, 1956, 5141, 3]}, "items": [{"id": "p_1019", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1020", "content": "sulfonylureas [SEP] city, although common, has been reported only infrequently with sulfonylureas. For glyburide, a second-generation sulfonylurea, only two brie", "tokenized_content": [2, 26496, 16648, 1036, 3, 8318, 16, 2876, 3059, 16, 2258, 2252, 2568, 2444, 28177, 1956, 26496, 16648, 1036, 18, 1958, 3376, 13789, 2261, 16, 43, 2812, 17, 4841, 26496, 16648, 3]}, "items": [{"id": "p_1020", "content": "Sulfonylurea Compounds [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26496, 16648, 4300, 3, 3]}]}
{"query": {"id": "q_1021", "content": "glyburide [SEP] on, has been reported only infrequently with sulfonylureas. For glyburide, a second-generation sulfonylurea, only two brief reports of he", "tokenized_content": [2, 3376, 13789, 2261, 3, 1990, 16, 2258, 2252, 2568, 2444, 28177, 1956, 26496, 16648, 1036, 18, 1958, 3376, 13789, 2261, 16, 43, 2812, 17, 4841, 26496, 16648, 16, 2444, 2288, 3]}, "items": [{"id": "p_1021", "content": "Glyburide [SEP] An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3376, 13789, 2261, 3, 1925, 26818, 26496, 16648, 10533, 1956, 7728, 2551, 1942, 2690, 1927, 4891, 20194, 5482, 18, 3]}]}
{"query": {"id": "q_1022", "content": "sulfonylurea [SEP] city, although common, has been reported only infrequently with sulfonylureas. For glyburide, a second-generation sulfonylurea, only two bri", "tokenized_content": [2, 26496, 16648, 3, 8318, 16, 2876, 3059, 16, 2258, 2252, 2568, 2444, 28177, 1956, 26496, 16648, 1036, 18, 1958, 3376, 13789, 2261, 16, 43, 2812, 17, 4841, 26496, 16648, 16, 3]}, "items": [{"id": "p_1022", "content": "Sulfonylurea Compounds [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26496, 16648, 4300, 3, 3]}]}
{"query": {"id": "q_1023", "content": "type II diabetes mellitus [SEP] ly two brief reports of hepatotoxicity exist. Two patients with type II diabetes mellitus developed an acute hepatitis-like syndrome soon after initiatio", "tokenized_content": [2, 2601, 2890, 4032, 9695, 3, 7518, 2288, 5310, 4710, 1927, 24126, 5516, 18, 2288, 2132, 1956, 2601, 2890, 4032, 9695, 3530, 1925, 3939, 7977, 17, 3189, 4741, 12722, 2256, 2907, 3]}, "items": [{"id": "p_1023", "content": "Diabetes Mellitus, Type 2 [SEP] A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RE", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 16, 2601, 22, 3, 43, 17625, 1927, 4032, 9695, 1988, 1977, 2084, 4122, 17, 8487, 2014, 3100, 12, 17991, 6366, 13, 18, 2176, 1977, 4378, 6370, 2007, 4122, 1964, 3]}]}
{"query": {"id": "q_1024", "content": "acute hepatitis-like syndrome [SEP] exist. Two patients with type II diabetes mellitus developed an acute hepatitis-like syndrome soon after initiation of glyburide therapy. There was no serolo", "tokenized_content": [2, 3939, 7977, 17, 3189, 4741, 3, 5516, 18, 2288, 2132, 1956, 2601, 2890, 4032, 9695, 3530, 1925, 3939, 7977, 17, 3189, 4741, 12722, 2256, 6035, 1927, 3376, 13789, 2261, 3181, 3]}, "items": [{"id": "p_1024", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1025", "content": "viral infection [SEP] iation of glyburide therapy. There was no serologic evidence of viral infection, and a liver biopsy sample showed a histologic pattern consiste", "tokenized_content": [2, 4324, 2909, 3, 21006, 2001, 1927, 3376, 13789, 2261, 3181, 18, 2276, 1982, 2239, 27551, 3095, 1927, 4324, 2909, 16, 1930, 43, 3568, 6831, 2983, 2594, 43, 12434, 3114, 3149, 3]}, "items": [{"id": "p_1025", "content": "Virus Diseases [SEP] A general term for diseases produced by viruses.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3413, 3902, 3, 43, 3335, 2576, 1958, 3902, 4152, 2007, 6241, 18, 3]}]}
{"query": {"id": "q_1026", "content": "drug-induced hepatitis [SEP] liver biopsy sample showed a histologic pattern consistent with drug-induced hepatitis. Both patients recovered quickly after stopping glyburide thera", "tokenized_content": [2, 2838, 17, 2719, 7977, 3, 3568, 6831, 2983, 2594, 43, 12434, 3114, 3499, 1956, 2838, 17, 2719, 7977, 18, 2321, 2132, 8294, 10521, 2256, 20225, 3376, 13789, 2261, 2704, 1019, 3]}, "items": [{"id": "p_1026", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1027", "content": "Glyburide [SEP] herapy and have remained well for a follow-up period of 1 year. Glyburide can produce an acute hepatitis-like illness in some persons.", "tokenized_content": [2, 3376, 13789, 2261, 3, 3656, 18644, 1930, 2162, 5410, 2486, 1958, 43, 2396, 17, 2353, 3047, 1927, 21, 2476, 18, 3376, 13789, 2261, 2112, 5074, 1925, 3939, 7977, 17, 3189, 3]}, "items": [{"id": "p_1027", "content": "Glyburide [SEP] An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3376, 13789, 2261, 3, 1925, 26818, 26496, 16648, 10533, 1956, 7728, 2551, 1942, 2690, 1927, 4891, 20194, 5482, 18, 3]}]}
{"query": {"id": "q_1028", "content": "acute hepatitis-like illness [SEP] well for a follow-up period of 1 year. Glyburide can produce an acute hepatitis-like illness in some persons.", "tokenized_content": [2, 3939, 7977, 17, 3189, 6455, 3, 2486, 1958, 43, 2396, 17, 2353, 3047, 1927, 21, 2476, 18, 3376, 13789, 2261, 2112, 5074, 1925, 3939, 7977, 17, 3189, 6455, 1922, 2673, 3]}, "items": [{"id": "p_1028", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1029", "content": "hemorrhage [SEP] Systolic pressure variation is greater during hemorrhage than during sodium nitroprusside-induced hypotension in ventila", "tokenized_content": [2, 10489, 3, 8541, 3772, 4516, 1977, 3430, 2409, 10489, 2254, 2409, 5227, 8686, 2047, 3468, 2261, 17, 2719, 16453, 1922, 12644, 1019, 3]}, "items": [{"id": "p_1029", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_1030", "content": "sodium nitroprusside [SEP] lic pressure variation is greater during hemorrhage than during sodium nitroprusside-induced hypotension in ventilated dogs.", "tokenized_content": [2, 5227, 8686, 2047, 3468, 2261, 3, 10247, 3772, 4516, 1977, 3430, 2409, 10489, 2254, 2409, 5227, 8686, 2047, 3468, 2261, 17, 2719, 16453, 1922, 21666, 7894, 18, 3]}, "items": [{"id": "p_1030", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_1031", "content": "hypotension [SEP] ater during hemorrhage than during sodium nitroprusside-induced hypotension in ventilated dogs.", "tokenized_content": [2, 16453, 3, 30280, 1005, 2409, 10489, 2254, 2409, 5227, 8686, 2047, 3468, 2261, 17, 2719, 16453, 1922, 21666, 7894, 18, 3]}, "items": [{"id": "p_1031", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1032", "content": "hypotension [SEP] ve-pressure breath, was studied in ventilated dogs subjected to hypotension. Mean arterial pressure was decreased to 50 mm Hg for 30 minute", "tokenized_content": [2, 16453, 3, 3428, 17, 3772, 8735, 16, 1982, 3942, 1922, 21666, 7894, 6243, 1942, 16453, 18, 2667, 6624, 3772, 1982, 3261, 1942, 2761, 2489, 7175, 1958, 2627, 8623, 3]}, "items": [{"id": "p_1032", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1033", "content": "hemorrhage [SEP] ial pressure was decreased to 50 mm Hg for 30 minutes either by hemorrhage (HEM, n = 7) or by continuous infusion of sodium nitroprusside ", "tokenized_content": [2, 10489, 3, 11640, 1024, 3772, 1982, 3261, 1942, 2761, 2489, 7175, 1958, 2627, 4814, 3108, 2007, 10489, 12, 3243, 16, 56, 33, 27, 13, 2014, 2007, 4798, 7386, 1927, 5227, 3]}, "items": [{"id": "p_1033", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_1034", "content": "HEM [SEP]  was decreased to 50 mm Hg for 30 minutes either by hemorrhage (HEM, n = 7) or by continuous infusion of sodium nitroprusside (SNP,", "tokenized_content": [2, 3243, 3, 1982, 3261, 1942, 2761, 2489, 7175, 1958, 2627, 4814, 3108, 2007, 10489, 12, 3243, 16, 56, 33, 27, 13, 2014, 2007, 4798, 7386, 1927, 5227, 8686, 2047, 3468, 3]}, "items": [{"id": "p_1034", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_1035", "content": "sodium nitroprusside [SEP]  either by hemorrhage (HEM, n = 7) or by continuous infusion of sodium nitroprusside (SNP, n = 7). During HEM-induced hypotension the cardiac output", "tokenized_content": [2, 5227, 8686, 2047, 3468, 2261, 3, 3108, 2007, 10489, 12, 3243, 16, 56, 33, 27, 13, 2014, 2007, 4798, 7386, 1927, 5227, 8686, 2047, 3468, 2261, 12, 6821, 16, 56, 3]}, "items": [{"id": "p_1035", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_1036", "content": "SNP [SEP] (HEM, n = 7) or by continuous infusion of sodium nitroprusside (SNP, n = 7). During HEM-induced hypotension the cardiac output was ", "tokenized_content": [2, 6821, 3, 12, 3243, 16, 56, 33, 27, 13, 2014, 2007, 4798, 7386, 1927, 5227, 8686, 2047, 3468, 2261, 12, 6821, 16, 56, 33, 27, 13, 18, 2409, 3243, 17, 3]}, "items": [{"id": "p_1036", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_1037", "content": "hypotensive [SEP] increases in the SPV and the delta down are characteristic of a hypotensive state due to a predominant decrease in preload. They are thus m", "tokenized_content": [2, 12201, 3766, 3, 4041, 1922, 1920, 2056, 1020, 1930, 1920, 9649, 3292, 2032, 6293, 1927, 43, 12201, 3766, 3360, 2810, 1942, 43, 6136, 3714, 1922, 27885, 18, 2611, 2032, 2842, 3]}, "items": [{"id": "p_1037", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1038", "content": "hypovolemia [SEP] crease in preload. They are thus more important during absolute hypovolemia than during deliberate hypotension.", "tokenized_content": [2, 14395, 27602, 3847, 3, 3478, 2051, 1922, 27885, 18, 2611, 2032, 2842, 2253, 2715, 2409, 6961, 14395, 27602, 3847, 2254, 2409, 24921, 13108, 16453, 18, 3]}, "items": [{"id": "p_1038", "content": "Hypovolemia [SEP] An abnormally low volume of blood circulating through the body. It may result in hypovolemic shock (see SHOCK).\n    ", "score": 1, "type": null, "tokenized_content": [2, 14395, 27602, 3847, 3, 1925, 20756, 2330, 3776, 1927, 2877, 7396, 2596, 1920, 3362, 18, 2176, 2278, 3211, 1922, 14395, 27602, 4197, 7418, 12, 3365, 7418, 13, 18, 3]}]}
{"query": {"id": "q_1039", "content": "spasm [SEP] Drug-induced arterial spasm relieved by lidocaine. Case report.", "tokenized_content": [2, 24431, 3, 2838, 17, 2719, 6624, 24431, 27919, 2007, 19567, 18, 3087, 3809, 18, 3]}, "items": [{"id": "p_1039", "content": "Spasm [SEP] An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24431, 3, 1925, 28493, 8332, 1927, 43, 3760, 2014, 2210, 1927, 7848, 18, 24431, 1036, 2278, 8156, 7345, 3760, 2014, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_1040", "content": "lidocaine [SEP] Drug-induced arterial spasm relieved by lidocaine. Case report.", "tokenized_content": [2, 19567, 3, 2838, 17, 2719, 6624, 24431, 27919, 2007, 19567, 18, 3087, 3809, 18, 3]}, "items": [{"id": "p_1040", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_1041", "content": "sodium pentothal [SEP] Following major intracranial surgery in a 35-year-old man, sodium pentothal was intravenously infused to minimize cerebral ischaemia. Inten", "tokenized_content": [2, 5227, 9412, 2195, 1923, 3, 2894, 3044, 12179, 3782, 1922, 43, 3259, 17, 2476, 17, 4156, 2323, 16, 5227, 9412, 2195, 1923, 1982, 15132, 15610, 1942, 9491, 6329, 22927, 18, 3]}, "items": [{"id": "p_1041", "content": "Thiopental [SEP] A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anest", "score": 1, "type": null, "tokenized_content": [2, 15331, 17125, 2381, 3, 43, 30434, 4219, 5524, 2057, 1988, 1977, 5254, 15132, 1958, 1920, 4408, 1927, 3335, 8871, 2014, 1958, 1920, 3372, 1927, 4080, 9860, 2156, 3]}]}
{"query": {"id": "q_1042", "content": "cerebral ischaemia [SEP] old man, sodium pentothal was intravenously infused to minimize cerebral ischaemia. Intense vasospasm with threatened gangrene arose in the arm us", "tokenized_content": [2, 6329, 22927, 3, 4156, 2323, 16, 5227, 9412, 2195, 1923, 1982, 15132, 15610, 1942, 9491, 6329, 22927, 18, 10702, 22866, 3508, 2691, 1956, 26947, 16249, 26774, 1021, 19521, 1922, 1920, 3]}, "items": [{"id": "p_1042", "content": "Brain Ischemia [SEP] Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs ", "score": 1, "type": null, "tokenized_content": [2, 3068, 7716, 3, 6579, 3378, 1927, 2877, 3426, 1942, 3068, 2960, 2810, 1942, 6624, 10849, 2014, 5510, 26497, 1915, 9049, 18, 2052, 5467, 5110, 3]}]}
{"query": {"id": "q_1043", "content": "vasospasm [SEP] s intravenously infused to minimize cerebral ischaemia. Intense vasospasm with threatened gangrene arose in the arm used for the infusion", "tokenized_content": [2, 22866, 3508, 2691, 3, 61, 15132, 15610, 1942, 9491, 6329, 22927, 18, 10702, 22866, 3508, 2691, 1956, 26947, 16249, 26774, 1021, 19521, 1922, 1920, 6011, 2251, 1958, 1920, 7386, 3]}, "items": [{"id": "p_1043", "content": "Vasospasm, Intracranial [SEP] Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Int", "score": 1, "type": null, "tokenized_content": [2, 22866, 3508, 2691, 16, 12179, 3, 19837, 1927, 9345, 1922, 1920, 13682, 2810, 1942, 12446, 16, 11707, 16, 1930, 3868, 7733, 6689, 3760, 8332, 1922, 2877, 7208, 18, 2218, 3]}]}
{"query": {"id": "q_1044", "content": "gangrene [SEP]  minimize cerebral ischaemia. Intense vasospasm with threatened gangrene arose in the arm used for the infusion. Since the cranial condi", "tokenized_content": [2, 16249, 26774, 1021, 3, 9491, 6329, 22927, 18, 10702, 22866, 3508, 2691, 1956, 26947, 16249, 26774, 1021, 19521, 1922, 1920, 6011, 2251, 1958, 1920, 7386, 18, 3328, 1920, 13598, 8646, 3]}, "items": [{"id": "p_1044", "content": "Gangrene [SEP] Death and putrefaction of tissue usually due to a loss of blood supply.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16249, 26774, 1021, 3, 3539, 1930, 5366, 24864, 2314, 1927, 2960, 5394, 2810, 1942, 43, 3257, 1927, 2877, 9042, 18, 3]}]}
{"query": {"id": "q_1045", "content": "lidocaine [SEP] ince the cranial condition precluded use of more usual methods, lidocaine was given intra-arterially, with careful cardiovascular monitor", "tokenized_content": [2, 19567, 3, 2043, 1021, 1920, 13598, 2625, 26550, 2485, 1927, 2253, 10616, 2860, 16, 19567, 1982, 3258, 5153, 17, 6624, 1954, 16, 1956, 8279, 5321, 8434, 3]}, "items": [{"id": "p_1045", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_1046", "content": "isoflurane [SEP] Cerebral blood flow and metabolism during isoflurane-induced hypotension in patients subjected to surgery for cerebr", "tokenized_content": [2, 15362, 3, 6329, 2877, 3426, 1930, 4714, 2409, 15362, 17, 2719, 16453, 1922, 2132, 6243, 1942, 3782, 1958, 6626, 1005, 3]}, "items": [{"id": "p_1046", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_1047", "content": "hypotension [SEP] Cerebral blood flow and metabolism during isoflurane-induced hypotension in patients subjected to surgery for cerebral aneurysms.", "tokenized_content": [2, 16453, 3, 6329, 2877, 3426, 1930, 4714, 2409, 15362, 17, 2719, 16453, 1922, 2132, 6243, 1942, 3782, 1958, 6329, 16673, 18, 3]}, "items": [{"id": "p_1047", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1048", "content": "cerebral aneurysms [SEP] lurane-induced hypotension in patients subjected to surgery for cerebral aneurysms.", "tokenized_content": [2, 6329, 16673, 3, 10908, 10513, 17, 2719, 16453, 1922, 2132, 6243, 1942, 3782, 1958, 6329, 16673, 18, 3]}, "items": [{"id": "p_1048", "content": "Intracranial Aneurysm [SEP] Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch", "score": 1, "type": null, "tokenized_content": [2, 12179, 13373, 3, 4552, 2397, 7056, 16908, 2029, 1922, 1920, 4821, 1927, 12179, 2877, 7208, 18, 2501, 3059, 2032, 1920, 12988, 2168, 12, 28195, 13, 16673, 4810, 2019, 6089, 3]}]}
{"query": {"id": "q_1049", "content": "oxygen [SEP] Cerebral blood flow and cerebral metabolic rate for oxygen were measured during isoflurane-induced hypotension in 10 patie", "tokenized_content": [2, 4612, 3, 6329, 2877, 3426, 1930, 6329, 4487, 2769, 1958, 4612, 1985, 3045, 2409, 15362, 17, 2719, 16453, 1922, 2119, 2091, 1021, 3]}, "items": [{"id": "p_1049", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_1050", "content": "isoflurane [SEP] low and cerebral metabolic rate for oxygen were measured during isoflurane-induced hypotension in 10 patients subjected to craniotomy for ", "tokenized_content": [2, 15362, 3, 2330, 1930, 6329, 4487, 2769, 1958, 4612, 1985, 3045, 2409, 15362, 17, 2719, 16453, 1922, 2119, 2132, 6243, 1942, 21204, 4575, 14930, 1958, 3]}, "items": [{"id": "p_1050", "content": "Isoflurane [SEP] A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15362, 3, 43, 4700, 16, 2447, 17, 22911, 2320, 14728, 16111, 16, 4322, 3294, 2037, 2228, 4159, 2564, 18, 3]}]}
{"query": {"id": "q_1051", "content": "hypotension [SEP] tabolic rate for oxygen were measured during isoflurane-induced hypotension in 10 patients subjected to craniotomy for clipping of a cerebr", "tokenized_content": [2, 16453, 3, 8514, 4485, 2769, 1958, 4612, 1985, 3045, 2409, 15362, 17, 2719, 16453, 1922, 2119, 2132, 6243, 1942, 21204, 4575, 14930, 1958, 18709, 9219, 1927, 43, 6626, 1005, 3]}, "items": [{"id": "p_1051", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1052", "content": "cerebral aneurysm [SEP] ension in 10 patients subjected to craniotomy for clipping of a cerebral aneurysm. Flow and metabolism were measured 5-13 days after the subarach", "tokenized_content": [2, 6329, 13373, 3, 4847, 2001, 1922, 2119, 2132, 6243, 1942, 21204, 4575, 14930, 1958, 18709, 9219, 1927, 43, 6329, 13373, 18, 3426, 1930, 4714, 1985, 3045, 25, 17, 2590, 3000, 3]}, "items": [{"id": "p_1052", "content": "Intracranial Aneurysm [SEP] Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch", "score": 1, "type": null, "tokenized_content": [2, 12179, 13373, 3, 4552, 2397, 7056, 16908, 2029, 1922, 1920, 4821, 1927, 12179, 2877, 7208, 18, 2501, 3059, 2032, 1920, 12988, 2168, 12, 28195, 13, 16673, 4810, 2019, 6089, 3]}]}
{"query": {"id": "q_1053", "content": "subarachnoid haemorrhage [SEP] aneurysm. Flow and metabolism were measured 5-13 days after the subarachnoid haemorrhage by a modification of the classical Kety-Schmidt technique using", "tokenized_content": [2, 23795, 23352, 3, 13373, 18, 3426, 1930, 4714, 1985, 3045, 25, 17, 2590, 3000, 2256, 1920, 23795, 23352, 2007, 43, 6295, 1927, 1920, 8445, 7892, 1012, 17, 25240, 4778, 2193, 3]}, "items": [{"id": "p_1053", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_1054", "content": "xenon [SEP] by a modification of the classical Kety-Schmidt technique using xenon-133 i.v. Anaesthesia was maintained with an inspired isoflurane", "tokenized_content": [2, 7085, 1916, 3, 2007, 43, 6295, 1927, 1920, 8445, 7892, 1012, 17, 25240, 4778, 2193, 7085, 1916, 17, 12147, 51, 18, 64, 18, 17107, 1982, 5514, 1956, 1925, 19046, 15362, 3]}, "items": [{"id": "p_1054", "content": "Xenon [SEP] A noble gas with the atomic symbol Xe, atomic number 54, and atomic weight 131.30. It is found in the earth's atmosphere and has", "score": 1, "type": null, "tokenized_content": [2, 7085, 1916, 3, 43, 2239, 7272, 4422, 1956, 1920, 11241, 17530, 29767, 16, 11241, 2529, 4584, 16, 1930, 11241, 3388, 11389, 18, 2627, 18, 2176, 1977, 2435, 1922, 1920, 13151, 11, 61, 12246, 1930, 2258, 3]}]}
{"query": {"id": "q_1055", "content": "nitrous oxide [SEP] ed with an inspired isoflurane concentration of 0.75% (plus 67% nitrous oxide in oxygen), during which CBF and CMRO2 were 34.3 +/- 2.1 ml/100", "tokenized_content": [2, 8686, 1957, 7491, 3, 3347, 1956, 1925, 19046, 15362, 3110, 1927, 20, 18, 4089, 9, 12, 5390, 4838, 9, 8686, 1957, 7491, 1922, 4612, 13, 16, 2409, 2154, 14716, 1930, 3]}, "items": [{"id": "p_1055", "content": "Nitrous Oxide [SEP] Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcoti", "score": 1, "type": null, "tokenized_content": [2, 8686, 1957, 7491, 3, 6634, 7491, 12, 25438, 13, 18, 43, 29500, 16, 12685, 5427, 4422, 1988, 1977, 2251, 1966, 1925, 16111, 1930, 14501, 18, 2149, 3295, 3936, 43, 22872, 13323, 3]}]}
{"query": {"id": "q_1056", "content": "Hg [SEP]  +/- SEM). Controlled hypotension to an average MAP of 50-55 mm Hg was induced by increasing the dose of isoflurane, and maintaine", "tokenized_content": [2, 7175, 3, 15, 19, 17, 3973, 13, 18, 4642, 16453, 1942, 1925, 3361, 4446, 1927, 2761, 17, 4288, 2489, 7175, 1982, 2719, 2007, 3605, 1920, 3253, 1927, 15362, 16, 1930, 3]}, "items": [{"id": "p_1056", "content": "Mercury [SEP] A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid sil", "score": 1, "type": null, "tokenized_content": [2, 15727, 3, 43, 11078, 16790, 6149, 1988, 8655, 1966, 43, 5875, 2019, 4921, 3449, 18, 2176, 2258, 1920, 11241, 17530, 7175, 12, 2037, 22420, 1005, 26983, 24277, 16, 5875, 4059, 3]}]}
{"query": {"id": "q_1057", "content": "aneurysm [SEP]  10 patients subjected to craniotomy for clipping of a cerebral aneurysm. Flow and metabolism were measured 5-13 days after the subarach", "tokenized_content": [2, 13373, 3, 2119, 2132, 6243, 1942, 21204, 4575, 14930, 1958, 18709, 9219, 1927, 43, 6329, 13373, 18, 3426, 1930, 4714, 1985, 3045, 25, 17, 2590, 3000, 2256, 1920, 23512, 3]}, "items": [{"id": "p_1057", "content": "Aneurysm [SEP] Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM", "score": 1, "type": null, "tokenized_content": [2, 13373, 3, 6598, 2397, 7056, 16908, 2029, 2014, 10791, 17, 3189, 17799, 1922, 1920, 4821, 1927, 2967, 2877, 8072, 12, 9345, 2014, 14785, 13, 2014, 1920, 4003, 12, 4003, 13373, 3]}]}
{"query": {"id": "q_1058", "content": "hypotensive [SEP] ncrease in CBF, although CMRO2 was unchanged, compared with pre-hypotensive values. These changes might offer protection to brain tissue du", "tokenized_content": [2, 12201, 3766, 3, 16122, 18013, 1021, 1922, 14716, 16, 2876, 17831, 5265, 1982, 9913, 16, 2452, 1956, 2097, 17, 12201, 3766, 2851, 18, 2144, 2840, 3284, 6260, 6202, 1942, 3068, 3]}, "items": [{"id": "p_1058", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1059", "content": "Allergic reaction [SEP] Allergic reaction to 5-fluorouracil infusion.", "tokenized_content": [2, 10519, 3227, 3, 10519, 3227, 1942, 25, 17, 21353, 7386, 18, 3]}, "items": [{"id": "p_1059", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1060", "content": "5-fluorouracil [SEP] Allergic reaction to 5-fluorouracil infusion.", "tokenized_content": [2, 25, 17, 21353, 3, 10519, 3227, 1942, 25, 17, 21353, 7386, 18, 3]}, "items": [{"id": "p_1060", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1061", "content": "allergic reaction [SEP] An allergic reaction consisting of angioneurotic edema secondary to continuous infus", "tokenized_content": [2, 10519, 3227, 3, 1925, 10519, 3227, 7600, 1927, 29220, 2912, 18916, 2002, 10144, 4067, 1942, 4798, 2122, 1957, 3]}, "items": [{"id": "p_1061", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1062", "content": "angioneurotic edema [SEP] An allergic reaction consisting of angioneurotic edema secondary to continuous infusion 5-fluorouracil occurred in a p", "tokenized_content": [2, 29220, 2912, 18916, 2002, 10144, 3, 1925, 10519, 3227, 7600, 1927, 29220, 2912, 18916, 2002, 10144, 4067, 1942, 4798, 7386, 25, 17, 21353, 4807, 1922, 43, 58, 3]}, "items": [{"id": "p_1062", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_1063", "content": "5-fluorouracil [SEP] sisting of angioneurotic edema secondary to continuous infusion 5-fluorouracil occurred in a patient with recurrent carcinoma of the oral cavi", "tokenized_content": [2, 25, 17, 21353, 3, 19149, 2104, 1927, 29220, 2912, 18916, 2002, 10144, 4067, 1942, 4798, 7386, 25, 17, 21353, 4807, 1922, 43, 2774, 1956, 7457, 5373, 1927, 1920, 4726, 9879, 3]}, "items": [{"id": "p_1063", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1064", "content": "carcinoma of the oral cavity [SEP] us infusion 5-fluorouracil occurred in a patient with recurrent carcinoma of the oral cavity, cirrhosis, and cisplatin-induced impaired renal function. This", "tokenized_content": [2, 5373, 1927, 1920, 4726, 8568, 3, 2022, 7386, 25, 17, 21353, 4807, 1922, 43, 2774, 1956, 7457, 5373, 1927, 1920, 4726, 8568, 16, 11260, 16, 1930, 9284, 17, 2719, 5761, 3]}, "items": [{"id": "p_1064", "content": "Mouth Neoplasms [SEP] Tumors or cancer of the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11701, 15347, 3, 3861, 2014, 2539, 1927, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_1065", "content": "cirrhosis [SEP] urred in a patient with recurrent carcinoma of the oral cavity, cirrhosis, and cisplatin-induced impaired renal function. This reaction o", "tokenized_content": [2, 11260, 3, 3674, 3510, 1922, 43, 2774, 1956, 7457, 5373, 1927, 1920, 4726, 8568, 16, 11260, 16, 1930, 9284, 17, 2719, 5761, 4604, 2347, 18, 2052, 3227, 57, 3]}, "items": [{"id": "p_1065", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_1066", "content": "cisplatin [SEP] ent with recurrent carcinoma of the oral cavity, cirrhosis, and cisplatin-induced impaired renal function. This reaction occurred during ", "tokenized_content": [2, 9284, 3, 8496, 1956, 7457, 5373, 1927, 1920, 4726, 8568, 16, 11260, 16, 1930, 9284, 17, 2719, 5761, 4604, 2347, 18, 2052, 3227, 4807, 2409, 3]}, "items": [{"id": "p_1066", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_1067", "content": "impaired renal function [SEP]  carcinoma of the oral cavity, cirrhosis, and cisplatin-induced impaired renal function. This reaction occurred during the sixth and seventh courses of", "tokenized_content": [2, 5761, 4604, 2347, 3, 5373, 1927, 1920, 4726, 8568, 16, 11260, 16, 1930, 9284, 17, 2719, 5761, 4604, 2347, 18, 2052, 3227, 4807, 2409, 1920, 17961, 1930, 21865, 12726, 1927, 3]}, "items": [{"id": "p_1067", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1068", "content": "diphenhydramine [SEP]  the sixth and seventh courses of infusional chemotherapy. Oral diphenhydramine and prednisone were ineffective in preventing the recurrence of", "tokenized_content": [2, 11791, 18107, 2584, 29085, 2053, 3, 1920, 17961, 1930, 21865, 12726, 1927, 7386, 1923, 5318, 18, 4726, 11791, 18107, 2584, 29085, 2053, 1930, 20405, 1985, 15302, 1922, 8444, 1920, 6339, 3]}, "items": [{"id": "p_1068", "content": "Diphenhydramine [SEP] A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a ", "score": 1, "type": null, "tokenized_content": [2, 11791, 18107, 2584, 29085, 2053, 3, 43, 14622, 9169, 8151, 2251, 1966, 1925, 2246, 17800, 2002, 16, 10310, 3468, 2320, 16, 1958, 13467, 12278, 1930, 27496, 16, 1958, 14625, 5298, 16, 1966, 43, 3]}]}
{"query": {"id": "q_1069", "content": "prednisone [SEP] th courses of infusional chemotherapy. Oral diphenhydramine and prednisone were ineffective in preventing the recurrence of the allergic r", "tokenized_content": [2, 20405, 3, 1913, 12726, 1927, 7386, 1923, 5318, 18, 4726, 11791, 18107, 2584, 29085, 2053, 1930, 20405, 1985, 15302, 1922, 8444, 1920, 6339, 1927, 1920, 10519, 60, 3]}, "items": [{"id": "p_1069", "content": "Prednisone [SEP] A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in t", "score": 1, "type": null, "tokenized_content": [2, 20405, 3, 43, 6830, 2246, 17, 3769, 14469, 3595, 2037, 18964, 8142, 1021, 18, 2176, 1977, 12186, 22937, 1930, 9076, 1942, 22025, 1922, 62, 3]}]}
{"query": {"id": "q_1070", "content": "Amiodarone [SEP] Amiodarone-induced sinoatrial block.", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 15665, 25033, 2830, 1021, 17, 2719, 3132, 6952, 17075, 3367, 18, 3]}, "items": [{"id": "p_1070", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_1071", "content": "sinoatrial block [SEP] Amiodarone-induced sinoatrial block.", "tokenized_content": [2, 3132, 6952, 17075, 3367, 3, 15665, 25033, 2830, 1021, 17, 2719, 3132, 6952, 17075, 3367, 18, 3]}, "items": [{"id": "p_1071", "content": "Sinoatrial Block [SEP] Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the SINOATRIAL NODE to the H", "score": 1, "type": null, "tokenized_content": [2, 3132, 6952, 17075, 3367, 3, 12732, 1922, 1920, 9224, 2936, 1988, 1977, 4189, 2007, 6809, 4574, 1927, 21896, 12382, 2037, 1920, 3132, 6952, 17075, 6267, 1942, 1920, 50, 3]}]}
{"query": {"id": "q_1072", "content": "sinoatrial block [SEP] We observed sinoatrial block due to chronic amiodarone administration in a 5-year-old boy wi", "tokenized_content": [2, 3132, 6952, 17075, 3367, 3, 2038, 2528, 3132, 6952, 17075, 3367, 2810, 1942, 3724, 15665, 25033, 2830, 1021, 4183, 1922, 43, 25, 17, 2476, 17, 4156, 17914, 11980, 3]}, "items": [{"id": "p_1072", "content": "Sinoatrial Block [SEP] Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the SINOATRIAL NODE to the H", "score": 1, "type": null, "tokenized_content": [2, 3132, 6952, 17075, 3367, 3, 12732, 1922, 1920, 9224, 2936, 1988, 1977, 4189, 2007, 6809, 4574, 1927, 21896, 12382, 2037, 1920, 3132, 6952, 17075, 6267, 1942, 1920, 50, 3]}]}
{"query": {"id": "q_1073", "content": "amiodarone [SEP] We observed sinoatrial block due to chronic amiodarone administration in a 5-year-old boy with primary cardiomyopathy,", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 2038, 2528, 3132, 6952, 17075, 3367, 2810, 1942, 3724, 15665, 25033, 2830, 1021, 4183, 1922, 43, 25, 17, 2476, 17, 4156, 17914, 1956, 3065, 14141, 3]}, "items": [{"id": "p_1073", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_1074", "content": "primary cardiomyopathy [SEP] e to chronic amiodarone administration in a 5-year-old boy with primary cardiomyopathy, Wolff-Parkinson-White syndrome and supraventricular tachycardi", "tokenized_content": [2, 3065, 14141, 3, 47, 1942, 3724, 15665, 25033, 2830, 1021, 4183, 1922, 43, 25, 17, 2476, 17, 4156, 17914, 1956, 3065, 14141, 16, 25254, 1038, 17, 10124, 17, 4511, 4741, 3]}, "items": [{"id": "p_1074", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1075", "content": "Wolff-Parkinson-White syndrome [SEP] administration in a 5-year-old boy with primary cardiomyopathy, Wolff-Parkinson-White syndrome and supraventricular tachycardia. Reduction in the dosage of am", "tokenized_content": [2, 25254, 1038, 17, 10124, 17, 4511, 4741, 3, 4183, 1922, 43, 25, 17, 2476, 17, 4156, 17914, 1956, 3065, 14141, 16, 25254, 1038, 17, 10124, 17, 4511, 4741, 1930, 21038, 3]}, "items": [{"id": "p_1075", "content": "Wolff-Parkinson-White Syndrome [SEP] A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syn", "score": 1, "type": null, "tokenized_content": [2, 25254, 1038, 17, 10124, 17, 4511, 4741, 3, 43, 2386, 1927, 6493, 2097, 17, 8392, 4378, 2007, 43, 3662, 2033, 4979, 1930, 43, 2815, 22355, 4979, 1956, 43, 9649, 5913, 18, 1922, 2052, 2540, 3]}]}
{"query": {"id": "q_1076", "content": "supraventricular tachycardia [SEP] with primary cardiomyopathy, Wolff-Parkinson-White syndrome and supraventricular tachycardia. Reduction in the dosage of amiodarone resulted in the disappea", "tokenized_content": [2, 21038, 24722, 17397, 3, 1956, 3065, 14141, 16, 25254, 1038, 17, 10124, 17, 4511, 4741, 1930, 21038, 24722, 17397, 18, 3378, 1922, 1920, 9998, 1927, 15665, 25033, 2830, 1021, 4306, 3]}, "items": [{"id": "p_1076", "content": "Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 21038, 24722, 3, 43, 13459, 2294, 1958, 2967, 17397, 1988, 22970, 3538, 1920, 14142, 1927, 4167, 18, 3]}]}
{"query": {"id": "q_1077", "content": "sinus bradycardia [SEP] nce of the sinoatrial block and the persistence of asymptomatic sinus bradycardia.", "tokenized_content": [2, 9414, 26192, 3, 5301, 1021, 1927, 1920, 3132, 6952, 17075, 3367, 1930, 1920, 10804, 1927, 9978, 9414, 26192, 18, 3]}, "items": [{"id": "p_1077", "content": "Sick Sinus Syndrome [SEP] A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impuls", "score": 1, "type": null, "tokenized_content": [2, 11258, 9414, 4741, 3, 43, 2625, 4189, 2007, 24199, 2712, 1942, 1920, 3132, 6952, 17075, 6267, 2710, 21896, 4841, 12, 4435, 9414, 8048, 13, 1930, 15396, 3]}]}
{"query": {"id": "q_1078", "content": "sulphasalazine [SEP] Possible teratogenicity of sulphasalazine.", "tokenized_content": [2, 13528, 14046, 10119, 3, 3216, 18909, 12758, 1927, 13528, 14046, 10119, 18, 3]}, "items": [{"id": "p_1078", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_1079", "content": "inflammatory bowel disease [SEP] Three infants, born of two mothers with inflammatory bowel disease who received treatment with sulphasalazine throughout pregnancy", "tokenized_content": [2, 3769, 9472, 2573, 3, 2559, 5969, 16, 8813, 1927, 2288, 7026, 1956, 3769, 9472, 2573, 2746, 4004, 2311, 1956, 13528, 14046, 10119, 5264, 5284, 3]}, "items": [{"id": "p_1079", "content": "Inflammatory Bowel Diseases [SEP] Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes C", "score": 1, "type": null, "tokenized_content": [2, 3769, 9472, 3902, 3, 3724, 16, 2447, 17, 2487, 4531, 1927, 1920, 8375, 6482, 18, 10383, 2278, 1998, 3299, 2014, 4813, 18, 2052, 2576, 5921, 45, 3]}]}
{"query": {"id": "q_1080", "content": "sulphasalazine [SEP] ers with inflammatory bowel disease who received treatment with sulphasalazine throughout pregnancy, were found to have major congenital anoma", "tokenized_content": [2, 13528, 14046, 10119, 3, 22877, 1956, 3769, 9472, 2573, 2746, 4004, 2311, 1956, 13528, 14046, 10119, 5264, 5284, 16, 1985, 2435, 1942, 2162, 3044, 9901, 28976, 3368, 3]}, "items": [{"id": "p_1080", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_1081", "content": "congenital anomalies [SEP] h sulphasalazine throughout pregnancy, were found to have major congenital anomalies. In the singleton pregnancy, the mother had ulcerative colitis,", "tokenized_content": [2, 9901, 13621, 3, 50, 13528, 14046, 10119, 5264, 5284, 16, 1985, 2435, 1942, 2162, 3044, 9901, 13621, 18, 1922, 1920, 23367, 5284, 16, 1920, 7999, 2430, 20428, 12087, 16, 3]}, "items": [{"id": "p_1081", "content": "Congenital Abnormalities [SEP] Malformations of organs or body parts during development in utero.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9901, 6754, 3, 17360, 1927, 7393, 2014, 3362, 7516, 2409, 2740, 1922, 19738, 18, 3]}]}
{"query": {"id": "q_1082", "content": "ulcerative colitis [SEP] ongenital anomalies. In the singleton pregnancy, the mother had ulcerative colitis, and the infant, a male, had coarctation of the aorta and a ven", "tokenized_content": [2, 20428, 12087, 3, 1990, 2432, 2915, 13621, 18, 1922, 1920, 23367, 5284, 16, 1920, 7999, 2430, 20428, 12087, 16, 1930, 1920, 8125, 16, 43, 4005, 16, 2430, 10027, 15618, 4926, 3]}, "items": [{"id": "p_1082", "content": "Colitis, Ulcerative [SEP] Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, th", "score": 1, "type": null, "tokenized_content": [2, 12087, 16, 20428, 3, 4531, 1927, 1920, 4120, 1988, 1977, 7700, 13184, 1942, 1920, 9680, 18, 2496, 3044, 3601, 3951, 11904, 16, 11635, 7633, 16, 1913, 3]}]}
{"query": {"id": "q_1083", "content": "coarctation of the aorta [SEP]  the mother had ulcerative colitis, and the infant, a male, had coarctation of the aorta and a ventricular septal defect. In the twin pregnancy, the mot", "tokenized_content": [2, 10027, 15618, 4926, 1927, 1920, 11859, 3, 1920, 7999, 2430, 20428, 12087, 16, 1930, 1920, 8125, 16, 43, 4005, 16, 2430, 10027, 15618, 4926, 1927, 1920, 11859, 1930, 43, 6493, 3]}, "items": [{"id": "p_1083", "content": "Aortic Coarctation [SEP] A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse ar", "score": 1, "type": null, "tokenized_content": [2, 7677, 10027, 15618, 4926, 3, 43, 5043, 7374, 4378, 2007, 1920, 21005, 1927, 1920, 11859, 1988, 2112, 1998, 1927, 7155, 4647, 1930, 2019, 2967, 3575, 2037, 1920, 11740, 2245, 3]}]}
{"query": {"id": "q_1084", "content": "ventricular septal defect [SEP] tis, and the infant, a male, had coarctation of the aorta and a ventricular septal defect. In the twin pregnancy, the mother had Crohn's disease. The fir", "tokenized_content": [2, 6493, 16458, 7374, 3, 30152, 16, 1930, 1920, 8125, 16, 43, 4005, 16, 2430, 10027, 15618, 4926, 1927, 1920, 11859, 1930, 43, 6493, 16458, 7374, 18, 1922, 1920, 13392, 5284, 3]}, "items": [{"id": "p_1084", "content": "Heart Septal Defects, Ventricular [SEP] Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower ", "score": 1, "type": null, "tokenized_content": [2, 4003, 16458, 6007, 16, 6493, 3, 5878, 6754, 1922, 2967, 7717, 1927, 1920, 6493, 17026, 3864, 1922, 4552, 20518, 2192, 1920, 2288, 2826, 3]}]}
{"query": {"id": "q_1085", "content": "Crohn's disease [SEP] entricular septal defect. In the twin pregnancy, the mother had Crohn's disease. The first twin, a female, had a left Potter-type IIa polycysti", "tokenized_content": [2, 17563, 11, 61, 2573, 3, 5695, 4588, 16458, 7374, 18, 1922, 1920, 13392, 5284, 16, 1920, 7999, 2430, 17563, 11, 61, 2573, 18, 1920, 2561, 13392, 16, 43, 4232, 16, 3]}, "items": [{"id": "p_1085", "content": "Crohn Disease [SEP] A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM", "score": 1, "type": null, "tokenized_content": [2, 17563, 2573, 3, 43, 3724, 30306, 4531, 1988, 2278, 8156, 2967, 3131, 1927, 1920, 15486, 6482, 2037, 11701, 1942, 1925, 1957, 16, 6969, 2435, 1922, 1920, 19269, 3]}]}
{"query": {"id": "q_1086", "content": "Potter-type IIa polycystic kidney [SEP] other had Crohn's disease. The first twin, a female, had a left Potter-type IIa polycystic kidney and a rudimentary left uterine cornu. The second twin, a male, ", "tokenized_content": [2, 2543, 1967, 17, 2601, 17433, 26316, 5245, 3, 2303, 2430, 17563, 11, 61, 2573, 18, 1920, 2561, 13392, 16, 43, 4232, 16, 2430, 43, 3506, 2543, 1967, 17, 2601, 17433, 3]}, "items": [{"id": "p_1086", "content": "Polycystic Kidney Diseases [SEP] Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KID", "score": 1, "type": null, "tokenized_content": [2, 26316, 5245, 3902, 3, 16321, 3902, 1988, 2032, 4378, 2007, 1920, 7529, 7013, 1927, 43, 3103, 2529, 1927, 12129, 15827, 13270, 2651, 1920, 4816, 3]}]}
{"query": {"id": "q_1087", "content": "talipes equinovarus [SEP] er's facies, hypoplastic lungs, absent kidneys and ureters, and talipes equinovarus. Despite reports to the contrary, it is suggested that sulphasa", "tokenized_content": [2, 11571, 29972, 3009, 3522, 19313, 1957, 3, 2668, 11, 61, 3186, 2062, 16, 26497, 24605, 2002, 9193, 16, 7685, 11770, 1930, 15168, 1036, 16, 1930, 11571, 29972, 3009, 3522, 19313, 3]}, "items": [{"id": "p_1087", "content": "Clubfoot [SEP] A deformed foot in which the foot is plantarflexed, inverted and adducted.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22375, 27048, 3, 43, 28466, 8135, 1922, 2154, 1920, 8135, 1977, 20043, 18222, 1919, 16, 12344, 1930, 18533, 1919, 18, 3]}]}
{"query": {"id": "q_1088", "content": "Veno-occlusive liver disease [SEP] Veno-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma.", "tokenized_content": [2, 8102, 1037, 17, 28715, 3568, 2573, 3, 8102, 1037, 17, 28715, 3568, 2573, 2256, 22322, 6299, 10119, 3181, 12, 17997, 1030, 13, 1958, 7033, 18, 3]}, "items": [{"id": "p_1088", "content": "Hepatic Veno-Occlusive Disease [SEP] Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS", "score": 1, "type": null, "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 3568, 2573, 1988, 1977, 4189, 2007, 8209, 1942, 1920, 5003, 2094, 1927, 1920, 7208, 1930, 2316, 27380, 10144, 16, 2308, 2084, 2007, 11354, 3]}]}
{"query": {"id": "q_1089", "content": "dacarbazine [SEP] Veno-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma.", "tokenized_content": [2, 22322, 6299, 10119, 3, 8102, 1037, 17, 28715, 3568, 2573, 2256, 22322, 6299, 10119, 3181, 12, 17997, 1030, 13, 1958, 7033, 18, 3]}, "items": [{"id": "p_1089", "content": "Dacarbazine [SEP] An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564", "score": 1, "type": null, "tokenized_content": [2, 22322, 6299, 10119, 3, 1925, 29128, 9969, 5899, 18, 2176, 2258, 2228, 2455, 3316, 20154, 18, 12, 2037, 14196, 3825, 1952, 16, 1920, 8324, 4602, 7540, 14209, 1019, 16, 3470, 2156, 3347, 16, 18974, 8760, 3]}]}
{"query": {"id": "q_1090", "content": "DTIC [SEP] Veno-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma.", "tokenized_content": [2, 17997, 1030, 3, 8102, 1037, 17, 28715, 3568, 2573, 2256, 22322, 6299, 10119, 3181, 12, 17997, 1030, 13, 1958, 7033, 18, 3]}, "items": [{"id": "p_1090", "content": "Dacarbazine [SEP] An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564", "score": 1, "type": null, "tokenized_content": [2, 22322, 6299, 10119, 3, 1925, 29128, 9969, 5899, 18, 2176, 2258, 2228, 2455, 3316, 20154, 18, 12, 2037, 14196, 3825, 1952, 16, 1920, 8324, 4602, 7540, 14209, 1019, 16, 3470, 2156, 3347, 16, 18974, 8760, 3]}]}
{"query": {"id": "q_1091", "content": "melanoma [SEP] no-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma.", "tokenized_content": [2, 7033, 3, 2239, 17, 28715, 3568, 2573, 2256, 22322, 6299, 10119, 3181, 12, 17997, 1030, 13, 1958, 7033, 18, 3]}, "items": [{"id": "p_1091", "content": "Melanoma [SEP] A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body", "score": 1, "type": null, "tokenized_content": [2, 7033, 3, 43, 6558, 12132, 3595, 2037, 2094, 1988, 2032, 7131, 1927, 7402, 20850, 16, 2154, 2278, 4704, 1922, 1920, 4407, 1927, 2967, 3131, 1927, 1920, 3362, 3]}]}
{"query": {"id": "q_1092", "content": "veno-occlusive disease of the liver [SEP] A case of veno-occlusive disease of the liver with fatal outcome after dacarbazine (DTIC) therapy for melanom", "tokenized_content": [2, 8102, 1037, 17, 28715, 2573, 1927, 1920, 3568, 3, 43, 3087, 1927, 8102, 1037, 17, 28715, 2573, 1927, 1920, 3568, 1956, 11990, 3924, 2256, 22322, 6299, 10119, 12, 17997, 1030, 3]}, "items": [{"id": "p_1092", "content": "Hepatic Veno-Occlusive Disease [SEP] Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS", "score": 1, "type": null, "tokenized_content": [2, 6095, 8102, 1037, 17, 28715, 2573, 3, 3568, 2573, 1988, 1977, 4189, 2007, 8209, 1942, 1920, 5003, 2094, 1927, 1920, 7208, 1930, 2316, 27380, 10144, 16, 2308, 2084, 2007, 11354, 3]}]}
{"query": {"id": "q_1093", "content": "dacarbazine [SEP] of veno-occlusive disease of the liver with fatal outcome after dacarbazine (DTIC) therapy for melanoma is reported. There was a fulminant ", "tokenized_content": [2, 22322, 6299, 10119, 3, 1927, 8102, 1037, 17, 28715, 2573, 1927, 1920, 3568, 1956, 11990, 3924, 2256, 22322, 6299, 10119, 12, 17997, 1030, 13, 3181, 1958, 7033, 1977, 2568, 18, 3]}, "items": [{"id": "p_1093", "content": "Dacarbazine [SEP] An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564", "score": 1, "type": null, "tokenized_content": [2, 22322, 6299, 10119, 3, 1925, 29128, 9969, 5899, 18, 2176, 2258, 2228, 2455, 3316, 20154, 18, 12, 2037, 14196, 3825, 1952, 16, 1920, 8324, 4602, 7540, 14209, 1019, 16, 3470, 2156, 3347, 16, 18974, 8760, 3]}]}
{"query": {"id": "q_1094", "content": "DTIC [SEP] sive disease of the liver with fatal outcome after dacarbazine (DTIC) therapy for melanoma is reported. There was a fulminant clinic", "tokenized_content": [2, 17997, 1030, 3, 14398, 1021, 2573, 1927, 1920, 3568, 1956, 11990, 3924, 2256, 22322, 6299, 10119, 12, 17997, 1030, 13, 3181, 1958, 7033, 1977, 2568, 18, 2276, 1982, 43, 5257, 3]}, "items": [{"id": "p_1094", "content": "Dacarbazine [SEP] An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564", "score": 1, "type": null, "tokenized_content": [2, 22322, 6299, 10119, 3, 1925, 29128, 9969, 5899, 18, 2176, 2258, 2228, 2455, 3316, 20154, 18, 12, 2037, 14196, 3825, 1952, 16, 1920, 8324, 4602, 7540, 14209, 1019, 16, 3470, 2156, 3347, 16, 18974, 8760, 3]}]}
{"query": {"id": "q_1095", "content": "melanoma [SEP] e liver with fatal outcome after dacarbazine (DTIC) therapy for melanoma is reported. There was a fulminant clinical course from start o", "tokenized_content": [2, 7033, 3, 47, 3568, 1956, 11990, 3924, 2256, 22322, 6299, 10119, 12, 17997, 1030, 13, 3181, 1958, 7033, 1977, 2568, 18, 2276, 1982, 43, 5257, 8547, 2031, 2535, 4914, 2037, 3]}, "items": [{"id": "p_1095", "content": "Melanoma [SEP] A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body", "score": 1, "type": null, "tokenized_content": [2, 7033, 3, 43, 6558, 12132, 3595, 2037, 2094, 1988, 2032, 7131, 1927, 7402, 20850, 16, 2154, 2278, 4704, 1922, 1920, 4407, 1927, 2967, 3131, 1927, 1920, 3362, 3]}]}
{"query": {"id": "q_1096", "content": "death [SEP] re was a fulminant clinical course from start of symptoms until death. At autopsy the liver was enlarged and firm with signs of venou", "tokenized_content": [2, 3539, 3, 1964, 1982, 43, 5257, 8547, 2031, 2535, 4914, 2037, 6413, 1927, 3601, 4801, 3539, 18, 2019, 16740, 1920, 3568, 1982, 13799, 1930, 15384, 1956, 6879, 1927, 8102, 4468, 3]}, "items": [{"id": "p_1096", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_1097", "content": "venous congestion [SEP] death. At autopsy the liver was enlarged and firm with signs of venous congestion. Small- and medium-sized hepatic veins were blocked by thrombos", "tokenized_content": [2, 8562, 24053, 3, 3539, 18, 2019, 16740, 1920, 3568, 1982, 13799, 1930, 15384, 1956, 6879, 1927, 8562, 24053, 18, 2858, 17, 1930, 3649, 17, 12177, 6095, 14785, 1985, 6923, 2007, 3]}, "items": [{"id": "p_1097", "content": "Hyperemia [SEP] The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. H", "score": 1, "type": null, "tokenized_content": [2, 24004, 6026, 3, 1920, 2990, 1927, 1925, 2502, 4351, 1927, 2877, 1922, 43, 3362, 3131, 2014, 1925, 3090, 4523, 1942, 24053, 2014, 3814, 1924, 2106, 2017, 1927, 2877, 7208, 18, 50, 3]}]}
{"query": {"id": "q_1098", "content": "thrombosis [SEP] ngestion. Small- and medium-sized hepatic veins were blocked by thrombosis. Eosinophilic infiltrations were found around the vessels. Publ", "tokenized_content": [2, 11354, 3, 4375, 2158, 2001, 18, 2858, 17, 1930, 3649, 17, 12177, 6095, 14785, 1985, 6923, 2007, 11354, 18, 21254, 8946, 1036, 1985, 2435, 4760, 1920, 7208, 18, 6780, 3]}, "items": [{"id": "p_1098", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_1099", "content": "tardive dyskinesia [SEP] A case of tardive dyskinesia caused by metoclopramide.", "tokenized_content": [2, 14517, 7408, 1961, 3890, 26682, 3, 43, 3087, 1927, 14517, 7408, 1961, 3890, 26682, 4189, 2007, 2130, 5406, 27148, 2261, 18, 3]}, "items": [{"id": "p_1099", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_1100", "content": "metoclopramide [SEP] A case of tardive dyskinesia caused by metoclopramide.", "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 43, 3087, 1927, 14517, 7408, 1961, 3890, 26682, 4189, 2007, 2130, 5406, 27148, 2261, 18, 3]}, "items": [{"id": "p_1100", "content": "Metoclopramide [SEP] A dopamine D2 antagonist that is used as an antiemetic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 43, 7964, 8631, 8151, 1988, 1977, 2251, 1966, 1925, 2246, 17800, 2002, 18, 3]}]}
{"query": {"id": "q_1101", "content": "Abnormal involuntary movements [SEP] Abnormal involuntary movements appeared in the mouth, tongue, neck and abdomen of a 64-year-ol", "tokenized_content": [2, 4552, 28493, 8264, 3, 4552, 28493, 8264, 6209, 1922, 1920, 11701, 16, 14761, 16, 7467, 1930, 14131, 1927, 43, 4723, 17, 2476, 17, 2865, 3]}, "items": [{"id": "p_1101", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_1102", "content": "metoclopramide [SEP] e, neck and abdomen of a 64-year-old male patient after he took metoclopramide for gastrointestinal disorder in a regimen of 30 mg per day for", "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 47, 16, 7467, 1930, 14131, 1927, 43, 4723, 17, 2476, 17, 4156, 4005, 2774, 2256, 2234, 8659, 2130, 5406, 27148, 2261, 1958, 8375, 4770, 1922, 3]}, "items": [{"id": "p_1102", "content": "Metoclopramide [SEP] A dopamine D2 antagonist that is used as an antiemetic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2130, 5406, 27148, 2261, 3, 43, 7964, 8631, 8151, 1988, 1977, 2251, 1966, 1925, 2246, 17800, 2002, 18, 3]}]}
{"query": {"id": "q_1103", "content": "gastrointestinal disorder [SEP]  of a 64-year-old male patient after he took metoclopramide for gastrointestinal disorder in a regimen of 30 mg per day for a total of about 260 days. Th", "tokenized_content": [2, 8375, 4770, 3, 1927, 43, 4723, 17, 2476, 17, 4156, 4005, 2774, 2256, 2234, 8659, 2130, 5406, 27148, 2261, 1958, 8375, 4770, 1922, 43, 8607, 1927, 2627, 2786, 2079, 3007, 3]}, "items": [{"id": "p_1103", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_1104", "content": "abnormal movements [SEP] h. When the metoclopramide administration was discontinued, the abnormal movements gradually improved to a considerable extent. Attention to the p", "tokenized_content": [2, 4552, 8264, 3, 50, 18, 2469, 1920, 2130, 5406, 27148, 2261, 4183, 1982, 16087, 16, 1920, 4552, 8264, 9690, 4305, 1942, 43, 7743, 5064, 18, 4976, 1942, 1920, 58, 3]}, "items": [{"id": "p_1104", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_1105", "content": "tardive dyskinesia [SEP] derable extent. Attention to the possible induction of specific tardive dyskinesia is called for in the use of this drug.", "tokenized_content": [2, 14517, 7408, 1961, 3890, 26682, 3, 3135, 2115, 5064, 18, 4976, 1942, 1920, 3216, 4408, 1927, 2487, 14517, 7408, 1961, 3890, 26682, 1977, 6043, 1958, 1922, 1920, 2485, 1927, 2052, 3]}, "items": [{"id": "p_1105", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_1106", "content": "amiodarone [SEP] Further observations on the electrophysiologic effects of oral amiodarone therapy.", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 2520, 5184, 1990, 1920, 11350, 12649, 2564, 1927, 4726, 15665, 25033, 2830, 1021, 3181, 18, 3]}, "items": [{"id": "p_1106", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_1107", "content": "intra-Hisian block [SEP] A case is presented of a reversible intra-Hisian block occurring under amiodarone treatment for atrial tachycardia in ", "tokenized_content": [2, 5153, 17, 4167, 3122, 3367, 3, 43, 3087, 1977, 3549, 1927, 43, 10743, 5153, 17, 4167, 3122, 3367, 6966, 2441, 15665, 25033, 2830, 1021, 2311, 1958, 9224, 17397, 1922, 3]}, "items": [{"id": "p_1107", "content": "Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE", "score": 1, "type": null, "tokenized_content": [2, 4003, 3367, 3, 5761, 12382, 1927, 4435, 21896, 1988, 2112, 4704, 2967, 26264, 4231, 1920, 12382, 3374, 16, 2427, 1966, 2192, 1920, 3132, 6952, 17075, 6267, 3]}]}
{"query": {"id": "q_1108", "content": "amiodarone [SEP] is presented of a reversible intra-Hisian block occurring under amiodarone treatment for atrial tachycardia in a patient without clear int", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1977, 3549, 1927, 43, 10743, 5153, 17, 4167, 3122, 3367, 6966, 2441, 15665, 25033, 2830, 1021, 2311, 1958, 9224, 17397, 1922, 43, 2774, 2979, 4021, 3]}, "items": [{"id": "p_1108", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_1109", "content": "atrial tachycardia [SEP] ble intra-Hisian block occurring under amiodarone treatment for atrial tachycardia in a patient without clear intraventricular conduction abnormal", "tokenized_content": [2, 9224, 17397, 3, 6189, 5153, 17, 4167, 3122, 3367, 6966, 2441, 15665, 25033, 2830, 1021, 2311, 1958, 9224, 17397, 1922, 43, 2774, 2979, 4021, 29510, 12382, 4552, 3]}, "items": [{"id": "p_1109", "content": "Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 21038, 24722, 3, 43, 13459, 2294, 1958, 2967, 17397, 1988, 22970, 3538, 1920, 14142, 1927, 4167, 18, 3]}]}
{"query": {"id": "q_1110", "content": "intraventricular conduction abnormalities [SEP] one treatment for atrial tachycardia in a patient without clear intraventricular conduction abnormalities. His bundle recordings showed an atrial tachycardia with interm", "tokenized_content": [2, 29510, 12382, 6754, 3, 2340, 2311, 1958, 9224, 17397, 1922, 43, 2774, 2979, 4021, 29510, 12382, 6754, 18, 4167, 14142, 9276, 2594, 1925, 9224, 17397, 1956, 15177, 3]}, "items": [{"id": "p_1110", "content": "Heart Septal Defects, Ventricular [SEP] Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower ", "score": 1, "type": null, "tokenized_content": [2, 4003, 16458, 6007, 16, 6493, 3, 5878, 6754, 1922, 2967, 7717, 1927, 1920, 6493, 17026, 3864, 1922, 4552, 20518, 2192, 1920, 2288, 2826, 3]}]}
{"query": {"id": "q_1111", "content": "atrial flutter [SEP] fter amiodarone discontinuation, His bundle electrograms showed atrial flutter without intra-Hisian or infra-Hisian delay. Amiodarone should b", "tokenized_content": [2, 9224, 2848, 3519, 1915, 3, 8916, 1915, 15665, 25033, 2830, 1021, 14775, 16, 4167, 14142, 4260, 28218, 2594, 9224, 2848, 3519, 1915, 2979, 5153, 17, 4167, 3122, 2014, 28307, 17, 3]}, "items": [{"id": "p_1111", "content": "Atrial Flutter [SEP] Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave", "score": 1, "type": null, "tokenized_content": [2, 9224, 2848, 3519, 1915, 3, 4052, 16, 11499, 9224, 15465, 4189, 2007, 43, 3367, 1927, 8287, 21896, 12382, 1922, 1920, 3659, 20548, 1930, 43, 21747, 4905, 17182, 1031, 5913, 3]}]}
{"query": {"id": "q_1112", "content": "Amiodarone [SEP] owed atrial flutter without intra-Hisian or infra-Hisian delay. Amiodarone should be used with caution during long-term oral therapy in pa", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 5073, 1919, 9224, 2848, 3519, 1915, 2979, 5153, 17, 4167, 3122, 2014, 28307, 17, 4167, 3122, 4989, 18, 15665, 25033, 2830, 1021, 3066, 1998, 2251, 3]}, "items": [{"id": "p_1112", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_1113", "content": "Busulfan [SEP] Busulfan-induced hemorrhagic cystitis.", "tokenized_content": [2, 11730, 4042, 1928, 3, 11730, 4042, 1928, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_1113", "content": "Busulfan [SEP] An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of ", "score": 1, "type": null, "tokenized_content": [2, 11730, 4042, 1928, 3, 1925, 28912, 5899, 4537, 43, 5328, 12910, 2495, 1990, 3622, 6599, 18, 2176, 2258, 2252, 2251, 1922, 1920, 13278, 2311, 1927, 3]}]}
{"query": {"id": "q_1114", "content": "hemorrhagic [SEP] Busulfan-induced hemorrhagic cystitis.", "tokenized_content": [2, 16052, 3, 11730, 4042, 1928, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_1114", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_1115", "content": "cystitis [SEP] Busulfan-induced hemorrhagic cystitis.", "tokenized_content": [2, 9446, 3678, 3, 11730, 4042, 1928, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_1115", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_1116", "content": "busulfan [SEP] A case of a busulfan-induced hemorrhage cystitis is reported. Spontaneous resolution", "tokenized_content": [2, 11730, 4042, 1928, 3, 43, 3087, 1927, 43, 11730, 4042, 1928, 17, 2719, 10489, 9446, 3678, 1977, 2568, 18, 6242, 4885, 3]}, "items": [{"id": "p_1116", "content": "Busulfan [SEP] An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of ", "score": 1, "type": null, "tokenized_content": [2, 11730, 4042, 1928, 3, 1925, 28912, 5899, 4537, 43, 5328, 12910, 2495, 1990, 3622, 6599, 18, 2176, 2258, 2252, 2251, 1922, 1920, 13278, 2311, 1927, 3]}]}
{"query": {"id": "q_1117", "content": "hemorrhage [SEP] A case of a busulfan-induced hemorrhage cystitis is reported. Spontaneous resolution occurred following", "tokenized_content": [2, 10489, 3, 43, 3087, 1927, 43, 11730, 4042, 1928, 17, 2719, 10489, 9446, 3678, 1977, 2568, 18, 6242, 4885, 4807, 2894, 3]}, "items": [{"id": "p_1117", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_1118", "content": "cystitis [SEP] A case of a busulfan-induced hemorrhage cystitis is reported. Spontaneous resolution occurred following cessatio", "tokenized_content": [2, 9446, 3678, 3, 43, 3087, 1927, 43, 11730, 4042, 1928, 17, 2719, 10489, 9446, 3678, 1977, 2568, 18, 6242, 4885, 4807, 2894, 10897, 1968, 1037, 3]}, "items": [{"id": "p_1118", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_1119", "content": "cyclophosphamide [SEP] tologic appearances of busulfan cystitis and both radiation and cyclophosphamide-induced cystitis is discussed and the world literature reviewed", "tokenized_content": [2, 17135, 3, 21930, 2021, 1935, 7818, 1036, 1927, 11730, 4042, 1928, 9446, 3678, 1930, 2321, 5442, 1930, 17135, 17, 2719, 9446, 3678, 1977, 5601, 1930, 1920, 4867, 4431, 5487, 3]}, "items": [{"id": "p_1119", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_1120", "content": "carcinoma [SEP] of the known tendency of busulfan to induce cellular atypia and carcinoma in other sites, periodic urinary cytology is suggested in patie", "tokenized_content": [2, 5373, 3, 1927, 1920, 3171, 10080, 1927, 11730, 4042, 1928, 1942, 4769, 3689, 10222, 2126, 1930, 5373, 1922, 2303, 3402, 16, 12922, 7075, 16598, 1977, 3978, 1922, 2091, 1021, 3]}, "items": [{"id": "p_1120", "content": "Carcinoma [SEP] A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It i", "score": 1, "type": null, "tokenized_content": [2, 5373, 3, 43, 6558, 12132, 3915, 2353, 1927, 4944, 2094, 5370, 1941, 1942, 19155, 1920, 7510, 3878, 1930, 7031, 7164, 1942, 8174, 18, 2176, 51, 3]}]}
{"query": {"id": "q_1121", "content": "hypertensive [SEP] Rebound hypertensive after sodium nitroprusside prevented by saralasin in rats.", "tokenized_content": [2, 11706, 3, 22845, 11706, 2256, 5227, 8686, 2047, 3468, 2261, 8715, 2007, 9851, 8056, 6777, 1922, 3615, 18, 3]}, "items": [{"id": "p_1121", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1122", "content": "sodium nitroprusside [SEP] Rebound hypertensive after sodium nitroprusside prevented by saralasin in rats.", "tokenized_content": [2, 5227, 8686, 2047, 3468, 2261, 3, 22845, 11706, 2256, 5227, 8686, 2047, 3468, 2261, 8715, 2007, 9851, 8056, 6777, 1922, 3615, 18, 3]}, "items": [{"id": "p_1122", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_1123", "content": "saralasin [SEP] Rebound hypertensive after sodium nitroprusside prevented by saralasin in rats.", "tokenized_content": [2, 9851, 8056, 6777, 3, 22845, 11706, 2256, 5227, 8686, 2047, 3468, 2261, 8715, 2007, 9851, 8056, 6777, 1922, 3615, 18, 3]}, "items": [{"id": "p_1123", "content": "Saralasin [SEP] An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It ", "score": 1, "type": null, "tokenized_content": [2, 9851, 8056, 6777, 3, 1925, 5843, 24010, 5729, 1927, 10814, 2890, 12, 6970, 13, 1956, 3835, 4576, 21, 1930, 28, 8403, 1956, 8747, 7506, 1930, 10504, 16, 2763, 18, 2176, 3]}]}
{"query": {"id": "q_1124", "content": "angiotensin [SEP] The role of the renin--angiotensin system in the maintenance of blood pressure during halothane an", "tokenized_content": [2, 10814, 3, 1920, 2770, 1927, 1920, 16306, 17, 17, 10814, 2433, 1922, 1920, 6291, 1927, 2877, 3772, 2409, 23226, 1963, 2516, 1925, 3]}, "items": [{"id": "p_1124", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_1125", "content": "halothane [SEP] -angiotensin system in the maintenance of blood pressure during halothane anesthesia and sodium nitroprusside (SNP)-induced hypotension w", "tokenized_content": [2, 23226, 1963, 2516, 3, 17, 10814, 2433, 1922, 1920, 6291, 1927, 2877, 3772, 2409, 23226, 1963, 2516, 8871, 1930, 5227, 8686, 2047, 3468, 2261, 12, 6821, 13, 17, 2719, 16453, 3]}, "items": [{"id": "p_1125", "content": "Halothane [SEP] A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analg", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 3, 43, 19136, 10082, 3368, 7272, 16, 24778, 1981, 16, 21638, 16111, 1988, 4558, 4322, 4052, 4408, 1956, 5082, 2014, 2239, 7817, 2855, 18, 2151, 1029, 3]}]}
{"query": {"id": "q_1126", "content": "sodium nitroprusside [SEP] e maintenance of blood pressure during halothane anesthesia and sodium nitroprusside (SNP)-induced hypotension was evaluated. Control rats received ", "tokenized_content": [2, 5227, 8686, 2047, 3468, 2261, 3, 47, 6291, 1927, 2877, 3772, 2409, 23226, 1963, 2516, 8871, 1930, 5227, 8686, 2047, 3468, 2261, 12, 6821, 13, 17, 2719, 16453, 1982, 3747, 3]}, "items": [{"id": "p_1126", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_1127", "content": "SNP [SEP]  pressure during halothane anesthesia and sodium nitroprusside (SNP)-induced hypotension was evaluated. Control rats received halot", "tokenized_content": [2, 6821, 3, 3772, 2409, 23226, 1963, 2516, 8871, 1930, 5227, 8686, 2047, 3468, 2261, 12, 6821, 13, 17, 2719, 16453, 1982, 3747, 18, 2285, 3615, 4004, 23226, 1031, 3]}, "items": [{"id": "p_1127", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_1128", "content": "hypotension [SEP] ing halothane anesthesia and sodium nitroprusside (SNP)-induced hypotension was evaluated. Control rats received halothane anesthesia (1 MA", "tokenized_content": [2, 16453, 3, 30393, 23226, 1963, 2516, 8871, 1930, 5227, 8686, 2047, 3468, 2261, 12, 6821, 13, 17, 2719, 16453, 1982, 3747, 18, 2285, 3615, 4004, 23226, 1963, 2516, 8871, 12, 3]}, "items": [{"id": "p_1128", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1129", "content": "saralasin [SEP] s treated identically and, in addition, received an infusion of saralasin (a competitive inhibitor of angiotensin II) throughout the expe", "tokenized_content": [2, 9851, 8056, 6777, 3, 61, 2868, 6119, 1954, 1930, 16, 1922, 2459, 16, 4004, 1925, 7386, 1927, 9851, 8056, 6777, 12, 43, 10362, 4106, 1927, 10814, 2890, 13, 5264, 1920, 3]}, "items": [{"id": "p_1129", "content": "Saralasin [SEP] An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It ", "score": 1, "type": null, "tokenized_content": [2, 9851, 8056, 6777, 3, 1925, 5843, 24010, 5729, 1927, 10814, 2890, 12, 6970, 13, 1956, 3835, 4576, 21, 1930, 28, 8403, 1956, 8747, 7506, 1930, 10504, 16, 2763, 18, 2176, 3]}]}
{"query": {"id": "q_1130", "content": "angiotensin II [SEP] , received an infusion of saralasin (a competitive inhibitor of angiotensin II) throughout the experimental period. In each group, SNP infusio", "tokenized_content": [2, 10814, 2890, 3, 16, 4004, 1925, 7386, 1927, 9851, 8056, 6777, 12, 43, 10362, 4106, 1927, 10814, 2890, 13, 5264, 1920, 3599, 3047, 18, 1922, 2362, 2210, 16, 6821, 2122, 3]}, "items": [{"id": "p_1130", "content": "Angiotensin II [SEP] An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino aci", "score": 1, "type": null, "tokenized_content": [2, 10814, 2890, 3, 1925, 5843, 24010, 1988, 1977, 43, 6828, 2308, 22001, 28404, 2684, 18, 2176, 1977, 4152, 2037, 10814, 51, 2256, 1920, 6025, 1927, 2288, 3835, 2000, 1033, 3]}]}
{"query": {"id": "q_1131", "content": "increase in blood pressure [SEP] the SNP infusion the control animals demonstrated a progressive increase in blood pressure to 61 torr, whereas the saralasin-treated animals showed no cha", "tokenized_content": [2, 2760, 1922, 2877, 3772, 3, 1920, 6821, 7386, 1920, 2285, 3555, 3161, 43, 7529, 2760, 1922, 2877, 3772, 1942, 5473, 27949, 16, 3417, 1920, 9851, 8056, 6777, 17, 2868, 3555, 3]}, "items": [{"id": "p_1131", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1132", "content": "hypotensive [SEP] n of the renin--angiotensin system in antagonizing the combined hypotensive effects of halothane and SNP.", "tokenized_content": [2, 12201, 3766, 3, 56, 1927, 1920, 16306, 17, 17, 10814, 2433, 1922, 5605, 3903, 1920, 4252, 12201, 3766, 2564, 1927, 23226, 1963, 2516, 1930, 6821, 18, 3]}, "items": [{"id": "p_1132", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1133", "content": "Toxic hepatitis [SEP] Toxic hepatitis induced by antithyroid drugs: four cases including one with cro", "tokenized_content": [2, 6161, 7977, 3, 6161, 7977, 2719, 2007, 10310, 30338, 12245, 4195, 30, 3006, 2919, 2710, 2340, 1956, 9442, 3]}, "items": [{"id": "p_1133", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1134", "content": "carbimazole [SEP] d drugs: four cases including one with cross-reactivity between carbimazole and benzylthiouracil.", "tokenized_content": [2, 3697, 12874, 13642, 1952, 3, 46, 4195, 30, 3006, 2919, 2710, 2340, 1956, 3567, 17, 8229, 2192, 3697, 12874, 13642, 1952, 1930, 17605, 22523, 20122, 18, 3]}, "items": [{"id": "p_1134", "content": "Carbimazole [SEP] An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity.\n  ", "score": 1, "type": null, "tokenized_content": [2, 3697, 12874, 13642, 1952, 3, 1925, 16045, 10310, 30338, 12245, 5899, 18, 3697, 12874, 13642, 1952, 1977, 19654, 1942, 2295, 12874, 13642, 1952, 16, 2154, 1977, 5061, 1958, 1920, 10310, 30338, 12245, 2455, 18, 3]}]}
{"query": {"id": "q_1135", "content": "benzylthiouracil [SEP] ses including one with cross-reactivity between carbimazole and benzylthiouracil.", "tokenized_content": [2, 17605, 22523, 20122, 3, 9924, 2710, 2340, 1956, 3567, 17, 8229, 2192, 3697, 12874, 13642, 1952, 1930, 17605, 22523, 20122, 18, 3]}, "items": [{"id": "p_1135", "content": "benzylthiouracil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17605, 22523, 20122, 3, 3]}]}
{"query": {"id": "q_1136", "content": "hepatic adverse effects [SEP] OBJECTIVE: This study was conducted to assess the occurrence of hepatic adverse effects encountered with antithyroid drugs. METHODS: Retrospective revi", "tokenized_content": [2, 6095, 5246, 2564, 3, 4470, 30, 2052, 2161, 1982, 3609, 1942, 2634, 1920, 6564, 1927, 6095, 5246, 2564, 11989, 1956, 10310, 30338, 12245, 4195, 18, 2860, 30, 6968, 5197, 1033, 3]}, "items": [{"id": "p_1136", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1137", "content": "hyperthyroidism [SEP] S: Retrospective review of medical records of 236 patients with hyperthyroidism admitted in our department (in- or out-patients) from 1986 to 1", "tokenized_content": [2, 28413, 3, 61, 30, 6968, 3043, 1927, 3423, 7123, 1927, 20098, 2132, 1956, 28413, 9723, 1922, 2342, 6143, 12, 1922, 17, 2014, 2397, 17, 2132, 13, 2037, 11367, 1942, 21, 3]}, "items": [{"id": "p_1137", "content": "Hyperthyroidism [SEP] Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.\n  ", "score": 1, "type": null, "tokenized_content": [2, 28413, 3, 10694, 1940, 10411, 2001, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 18, 4664, 2428, 1927, 6918, 10224, 2760, 5342, 4487, 2769, 18, 3]}]}
{"query": {"id": "q_1138", "content": "toxic hepatitis [SEP] 986 to 1992. RESULTS: Four patients (1.7%) were identified with toxic hepatitis which could reasonably be attributed to the use of antithyroid ", "tokenized_content": [2, 6161, 7977, 3, 5613, 1016, 1942, 8348, 18, 2274, 30, 3006, 2132, 12, 21, 18, 27, 9, 13, 1985, 2899, 1956, 6161, 7977, 2154, 2578, 18184, 1998, 6898, 1942, 1920, 3]}, "items": [{"id": "p_1138", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1139", "content": "cholestatic [SEP]  attributed to the use of antithyroid agent. Two patients had a cholestatic hepatitis induced by carbimazole (N  omercazole). Two others ha", "tokenized_content": [2, 21211, 2479, 3, 6898, 1942, 1920, 2485, 1927, 10310, 30338, 12245, 5899, 18, 2288, 2132, 2430, 43, 21211, 2479, 7977, 2719, 2007, 3697, 12874, 13642, 1952, 12, 56, 12453, 15618, 3]}, "items": [{"id": "p_1139", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_1140", "content": "hepatitis [SEP]  1992. RESULTS: Four patients (1.7%) were identified with toxic hepatitis which could reasonably be attributed to the use of antithyroid ", "tokenized_content": [2, 7977, 3, 8348, 18, 2274, 30, 3006, 2132, 12, 21, 18, 27, 9, 13, 1985, 2899, 1956, 6161, 7977, 2154, 2578, 18184, 1998, 6898, 1942, 1920, 2485, 1927, 10310, 30338, 3]}, "items": [{"id": "p_1140", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1141", "content": "carbimazole [SEP] roid agent. Two patients had a cholestatic hepatitis induced by carbimazole (N  omercazole). Two others had a mixed (cholestatic and cytoly", "tokenized_content": [2, 3697, 12874, 13642, 1952, 3, 11955, 1007, 5899, 18, 2288, 2132, 2430, 43, 21211, 2479, 7977, 2719, 2007, 3697, 12874, 13642, 1952, 12, 56, 12453, 15618, 6984, 13, 18, 2288, 3]}, "items": [{"id": "p_1141", "content": "Carbimazole [SEP] An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity.\n  ", "score": 1, "type": null, "tokenized_content": [2, 3697, 12874, 13642, 1952, 3, 1925, 16045, 10310, 30338, 12245, 5899, 18, 3697, 12874, 13642, 1952, 1977, 19654, 1942, 2295, 12874, 13642, 1952, 16, 2154, 1977, 5061, 1958, 1920, 10310, 30338, 12245, 2455, 18, 3]}]}
{"query": {"id": "q_1142", "content": "N  omercazole [SEP] wo patients had a cholestatic hepatitis induced by carbimazole (N  omercazole). Two others had a mixed (cholestatic and cytolytic) hepatitis ", "tokenized_content": [2, 56, 12453, 15618, 6984, 3, 26334, 2132, 2430, 43, 21211, 2479, 7977, 2719, 2007, 3697, 12874, 13642, 1952, 12, 56, 12453, 15618, 6984, 13, 18, 2288, 4991, 2430, 43, 4985, 3]}, "items": [{"id": "p_1142", "content": "Carbimazole [SEP] An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity.\n  ", "score": 1, "type": null, "tokenized_content": [2, 3697, 12874, 13642, 1952, 3, 1925, 16045, 10310, 30338, 12245, 5899, 18, 3697, 12874, 13642, 1952, 1977, 19654, 1942, 2295, 12874, 13642, 1952, 16, 2154, 1977, 5061, 1958, 1920, 10310, 30338, 12245, 2455, 18, 3]}]}
{"query": {"id": "q_1143", "content": "Benzylthiouracil [SEP]  further experienced a cytolytic hepatitis which appeared after Benzylthiouracil (Basd  ne) had replaced carbimazole. Biological features of hep", "tokenized_content": [2, 17605, 22523, 20122, 3, 2520, 6090, 43, 29198, 7977, 2154, 6209, 2256, 17605, 22523, 20122, 12, 2726, 1007, 2069, 13, 2430, 8403, 3697, 12874, 13642, 1952, 18, 3933, 4075, 1927, 3]}, "items": [{"id": "p_1143", "content": "benzylthiouracil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17605, 22523, 20122, 3, 3]}]}
{"query": {"id": "q_1144", "content": "Basd  ne [SEP] ed a cytolytic hepatitis which appeared after Benzylthiouracil (Basd  ne) had replaced carbimazole. Biological features of hepatitis dis", "tokenized_content": [2, 2726, 1007, 2069, 3, 3347, 43, 29198, 7977, 2154, 6209, 2256, 17605, 22523, 20122, 12, 2726, 1007, 2069, 13, 2430, 8403, 3697, 12874, 13642, 1952, 18, 3933, 4075, 1927, 7977, 3]}, "items": [{"id": "p_1144", "content": "benzylthiouracil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17605, 22523, 20122, 3, 3]}]}
{"query": {"id": "q_1145", "content": "neutropenia [SEP] atients of our retrospective study experienced a mild or severe neutropenia. CONCLUSION: Toxic hepatitis is a potential adverse effect of a", "tokenized_content": [2, 18005, 3, 2019, 6746, 1927, 2342, 6968, 2161, 6090, 43, 5809, 2014, 4010, 18005, 18, 4180, 30, 6161, 7977, 1977, 43, 2889, 5246, 2495, 1927, 43, 3]}, "items": [{"id": "p_1145", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1146", "content": "Toxic hepatitis [SEP] ive study experienced a mild or severe neutropenia. CONCLUSION: Toxic hepatitis is a potential adverse effect of antithyroid drugs which warran", "tokenized_content": [2, 6161, 7977, 3, 4370, 1021, 2161, 6090, 43, 5809, 2014, 4010, 18005, 18, 4180, 30, 6161, 7977, 1977, 43, 2889, 5246, 2495, 1927, 10310, 30338, 12245, 4195, 2154, 9231, 1928, 3]}, "items": [{"id": "p_1146", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1147", "content": "hepatotoxicity [SEP] d a careful follow-up of relevant biological markers. Moreover, hepatotoxicity may not be restricted to one class of antithyroid agents.", "tokenized_content": [2, 24126, 3, 46, 43, 8279, 2396, 17, 2353, 1927, 4494, 3933, 4432, 18, 3950, 16, 24126, 2278, 2084, 1998, 6715, 1942, 2340, 2921, 1927, 10310, 30338, 12245, 4820, 18, 3]}, "items": [{"id": "p_1147", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_1148", "content": "vitamin B12 [SEP] Study of the role of vitamin B12 and folinic acid supplementation in preventing hematologic toxi", "tokenized_content": [2, 6111, 17492, 3, 2161, 1927, 1920, 2770, 1927, 6111, 17492, 1930, 25783, 19730, 2687, 8746, 1922, 8444, 18251, 3780, 1033, 3]}, "items": [{"id": "p_1148", "content": "Vitamin B 12 [SEP] A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants", "score": 1, "type": null, "tokenized_content": [2, 6111, 44, 2369, 3, 43, 20773, 17, 3165, 9478, 3547, 4152, 2007, 6139, 2703, 17, 7373, 1930, 2435, 2222, 1922, 6072, 1930, 3224, 18, 2580, 4793, 3]}]}
{"query": {"id": "q_1149", "content": "folinic acid [SEP] Study of the role of vitamin B12 and folinic acid supplementation in preventing hematologic toxicity of zidovudin", "tokenized_content": [2, 25783, 19730, 2687, 3, 2161, 1927, 1920, 2770, 1927, 6111, 17492, 1930, 25783, 19730, 2687, 8746, 1922, 8444, 18251, 5532, 1927, 28666, 22389, 1020, 14287, 3]}, "items": [{"id": "p_1149", "content": "Leucovorin [SEP] The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists", "score": 1, "type": null, "tokenized_content": [2, 9906, 2579, 14258, 3, 1920, 3500, 9483, 1927, 19731, 2687, 18, 9906, 2579, 14258, 1977, 2251, 22581, 1966, 2496, 5016, 7012, 1966, 1925, 30483, 7229, 1942, 19731, 2687, 10515, 3]}]}
{"query": {"id": "q_1150", "content": "toxicity [SEP]  B12 and folinic acid supplementation in preventing hematologic toxicity of zidovudine.", "tokenized_content": [2, 5532, 3, 17492, 1930, 25783, 19730, 2687, 8746, 1922, 8444, 18251, 5532, 1927, 28666, 22389, 1020, 20597, 18, 3]}, "items": [{"id": "p_1150", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1151", "content": "zidovudine [SEP] inic acid supplementation in preventing hematologic toxicity of zidovudine.", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 1922, 1935, 2687, 8746, 1922, 8444, 18251, 5532, 1927, 28666, 22389, 1020, 20597, 18, 3]}, "items": [{"id": "p_1151", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_1152", "content": "vitamin B12 [SEP] pective, randomized study was conducted to evaluate the role of vitamin B12 and folinic acid supplementation in preventing zidovudine (ZDV)", "tokenized_content": [2, 6111, 17492, 3, 13494, 2185, 16, 5542, 2161, 1982, 3609, 1942, 4323, 1920, 2770, 1927, 6111, 17492, 1930, 25783, 19730, 2687, 8746, 1922, 8444, 28666, 22389, 1020, 20597, 12, 68, 3]}, "items": [{"id": "p_1152", "content": "Vitamin B 12 [SEP] A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants", "score": 1, "type": null, "tokenized_content": [2, 6111, 44, 2369, 3, 43, 20773, 17, 3165, 9478, 3547, 4152, 2007, 6139, 2703, 17, 7373, 1930, 2435, 2222, 1922, 6072, 1930, 3224, 18, 2580, 4793, 3]}]}
{"query": {"id": "q_1153", "content": "folinic acid [SEP] zed study was conducted to evaluate the role of vitamin B12 and folinic acid supplementation in preventing zidovudine (ZDV)-induced bone mar", "tokenized_content": [2, 25783, 19730, 2687, 3, 6116, 1007, 2161, 1982, 3609, 1942, 4323, 1920, 2770, 1927, 6111, 17492, 1930, 25783, 19730, 2687, 8746, 1922, 8444, 28666, 22389, 1020, 20597, 12, 68, 17332, 3]}, "items": [{"id": "p_1153", "content": "Leucovorin [SEP] The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists", "score": 1, "type": null, "tokenized_content": [2, 9906, 2579, 14258, 3, 1920, 3500, 9483, 1927, 19731, 2687, 18, 9906, 2579, 14258, 1977, 2251, 22581, 1966, 2496, 5016, 7012, 1966, 1925, 30483, 7229, 1942, 19731, 2687, 10515, 3]}]}
{"query": {"id": "q_1154", "content": "zidovudine [SEP] e of vitamin B12 and folinic acid supplementation in preventing zidovudine (ZDV)-induced bone marrow suppression. Seventy-five human immun", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 47, 1927, 6111, 17492, 1930, 25783, 19730, 2687, 8746, 1922, 8444, 28666, 22389, 1020, 20597, 12, 68, 17332, 13, 17, 2719, 3622, 6599, 6412, 18, 3]}, "items": [{"id": "p_1154", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_1155", "content": "ZDV [SEP]  B12 and folinic acid supplementation in preventing zidovudine (ZDV)-induced bone marrow suppression. Seventy-five human immunodefi", "tokenized_content": [2, 68, 17332, 3, 17492, 1930, 25783, 19730, 2687, 8746, 1922, 8444, 28666, 22389, 1020, 20597, 12, 68, 17332, 13, 17, 2719, 3622, 6599, 6412, 18, 16270, 17, 3628, 2616, 11969, 3]}, "items": [{"id": "p_1155", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_1156", "content": "bone marrow suppression [SEP] nic acid supplementation in preventing zidovudine (ZDV)-induced bone marrow suppression. Seventy-five human immunodeficiency virus (HIV)-infected patie", "tokenized_content": [2, 3622, 6599, 6412, 3, 11188, 2687, 8746, 1922, 8444, 28666, 22389, 1020, 20597, 12, 68, 17332, 13, 17, 2719, 3622, 6599, 6412, 18, 16270, 17, 3628, 2616, 13141, 3413, 12, 3]}, "items": [{"id": "p_1156", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_1157", "content": "human immunodeficiency virus (HIV)-infected [SEP]  zidovudine (ZDV)-induced bone marrow suppression. Seventy-five human immunodeficiency virus (HIV)-infected patients with CD4+ cell counts < 500/mm3 were randomized to rec", "tokenized_content": [2, 2616, 13141, 3413, 12, 3525, 13, 17, 4014, 3, 28666, 22389, 1020, 20597, 12, 68, 17332, 13, 17, 2719, 3622, 6599, 6412, 18, 16270, 17, 3628, 2616, 13141, 3413, 12, 3]}, "items": [{"id": "p_1157", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_1158", "content": "death [SEP] ly, 15 patients were excluded from the study (noncompliance 14, death 1); thus, 60 patients (31 in group I and 29 in group II) were e", "tokenized_content": [2, 3539, 3, 7518, 16, 2461, 2132, 1985, 5450, 2037, 1920, 2161, 12, 22849, 2030, 8195, 2607, 16, 3539, 21, 13, 31, 2842, 16, 3276, 2132, 12, 3470, 1922, 2210, 51, 3]}, "items": [{"id": "p_1158", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_1159", "content": "folate [SEP] ups were found at enrollment. During the study, vitamin B12 and folate levels were significantly higher in group II patients; however,", "tokenized_content": [2, 13761, 3, 15111, 1985, 2435, 2019, 11811, 18, 2409, 1920, 2161, 16, 6111, 17492, 1930, 13761, 2428, 1985, 2567, 2580, 1922, 2210, 2890, 2132, 31, 2406, 16, 3]}, "items": [{"id": "p_1159", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_1160", "content": "toxicity [SEP] ved between groups at 3, 6, 9 and 12 months. Severe hematologic toxicity (neutrophil count < 1000/mm3 and/or hemoglobin < 8 g/dl) occurr", "tokenized_content": [2, 5532, 3, 3428, 1007, 2192, 2671, 2019, 23, 16, 26, 16, 29, 1930, 2369, 3221, 18, 4010, 18251, 5532, 12, 9460, 6500, 32, 5672, 19, 14226, 1930, 19, 2014, 9652, 3]}, "items": [{"id": "p_1160", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1161", "content": "myelosuppression [SEP] elation between vitamin B12 or folate levels and development of myelosuppression. Vitamin B12 and folinic acid supplementation of ZDV therapy do", "tokenized_content": [2, 5707, 1951, 3481, 3124, 3, 2349, 1943, 2192, 6111, 17492, 2014, 13761, 2428, 1930, 2740, 1927, 5707, 1951, 3481, 3124, 18, 6111, 17492, 1930, 25783, 19730, 2687, 8746, 1927, 68, 3]}, "items": [{"id": "p_1161", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_1162", "content": "Vitamin B12 [SEP] tamin B12 or folate levels and development of myelosuppression. Vitamin B12 and folinic acid supplementation of ZDV therapy does not seem u", "tokenized_content": [2, 6111, 17492, 3, 9066, 1921, 17492, 2014, 13761, 2428, 1930, 2740, 1927, 5707, 1951, 3481, 3124, 18, 6111, 17492, 1930, 25783, 19730, 2687, 8746, 1927, 68, 17332, 3181, 3731, 2084, 3]}, "items": [{"id": "p_1162", "content": "Vitamin B 12 [SEP] A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants", "score": 1, "type": null, "tokenized_content": [2, 6111, 44, 2369, 3, 43, 20773, 17, 3165, 9478, 3547, 4152, 2007, 6139, 2703, 17, 7373, 1930, 2435, 2222, 1922, 6072, 1930, 3224, 18, 2580, 4793, 3]}]}
{"query": {"id": "q_1163", "content": "myelotoxicity [SEP] rapy does not seem useful in preventing or reducing ZDV-induced myelotoxicity in the overall treated population, although a beneficial effect", "tokenized_content": [2, 5707, 11930, 3, 3694, 1012, 3731, 2084, 6521, 4707, 1922, 8444, 2014, 5526, 68, 17332, 17, 2719, 5707, 11930, 1922, 1920, 3399, 2868, 2973, 16, 2876, 43, 6928, 2495, 3]}, "items": [{"id": "p_1163", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_1164", "content": "confusion [SEP] Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic a", "tokenized_content": [2, 18272, 3, 3939, 18272, 2719, 2007, 43, 2149, 17, 3253, 7386, 1927, 25, 17, 21353, 1930, 25783, 19730, 43, 3]}, "items": [{"id": "p_1164", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_1165", "content": "5-fluorouracil [SEP] Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.", "tokenized_content": [2, 25, 17, 21353, 3, 3939, 18272, 2719, 2007, 43, 2149, 17, 3253, 7386, 1927, 25, 17, 21353, 1930, 25783, 19730, 2687, 18, 3]}, "items": [{"id": "p_1165", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1166", "content": "folinic acid [SEP] confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.", "tokenized_content": [2, 25783, 19730, 2687, 3, 18272, 2719, 2007, 43, 2149, 17, 3253, 7386, 1927, 25, 17, 21353, 1930, 25783, 19730, 2687, 18, 3]}, "items": [{"id": "p_1166", "content": "Leucovorin [SEP] The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists", "score": 1, "type": null, "tokenized_content": [2, 9906, 2579, 14258, 3, 1920, 3500, 9483, 1927, 19731, 2687, 18, 9906, 2579, 14258, 1977, 2251, 22581, 1966, 2496, 5016, 7012, 1966, 1925, 30483, 7229, 1942, 19731, 2687, 10515, 3]}]}
{"query": {"id": "q_1167", "content": "cisplatinum [SEP] old man was treated with combination chemotherapy incorporating cisplatinum, etoposide, high-dose 5-fluorouracil (2,250 mg/m2/24 hours) and", "tokenized_content": [2, 9284, 1989, 3, 4156, 2323, 1982, 2868, 1956, 3921, 5318, 12553, 9284, 1989, 16, 18892, 16, 2149, 17, 3253, 25, 17, 21353, 12, 22, 16, 6330, 2786, 19, 6056, 19, 3]}, "items": [{"id": "p_1167", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_1168", "content": "etoposide [SEP] reated with combination chemotherapy incorporating cisplatinum, etoposide, high-dose 5-fluorouracil (2,250 mg/m2/24 hours) and folinic ac", "tokenized_content": [2, 18892, 3, 1964, 1981, 1956, 3921, 5318, 12553, 9284, 1989, 16, 18892, 16, 2149, 17, 3253, 25, 17, 21353, 12, 22, 16, 6330, 2786, 19, 6056, 19, 2686, 3967, 13, 3]}, "items": [{"id": "p_1168", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_1169", "content": "5-fluorouracil [SEP] on chemotherapy incorporating cisplatinum, etoposide, high-dose 5-fluorouracil (2,250 mg/m2/24 hours) and folinic acid for an inoperable gastr", "tokenized_content": [2, 25, 17, 21353, 3, 1990, 5318, 12553, 9284, 1989, 16, 18892, 16, 2149, 17, 3253, 25, 17, 21353, 12, 22, 16, 6330, 2786, 19, 6056, 19, 2686, 3967, 13, 1930, 3]}, "items": [{"id": "p_1169", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1170", "content": "folinic acid [SEP]  etoposide, high-dose 5-fluorouracil (2,250 mg/m2/24 hours) and folinic acid for an inoperable gastric adenocarcinoma. He developed acute ne", "tokenized_content": [2, 25783, 19730, 2687, 3, 18892, 16, 2149, 17, 3253, 25, 17, 21353, 12, 22, 16, 6330, 2786, 19, 6056, 19, 2686, 3967, 13, 1930, 25783, 19730, 2687, 1958, 1925, 26848, 3]}, "items": [{"id": "p_1170", "content": "Leucovorin [SEP] The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists", "score": 1, "type": null, "tokenized_content": [2, 9906, 2579, 14258, 3, 1920, 3500, 9483, 1927, 19731, 2687, 18, 9906, 2579, 14258, 1977, 2251, 22581, 1966, 2496, 5016, 7012, 1966, 1925, 30483, 7229, 1942, 19731, 2687, 10515, 3]}]}
{"query": {"id": "q_1171", "content": "gastric adenocarcinoma [SEP] racil (2,250 mg/m2/24 hours) and folinic acid for an inoperable gastric adenocarcinoma. He developed acute neurologic symptoms of mental confusion, di", "tokenized_content": [2, 6319, 9573, 3, 7195, 1970, 12, 22, 16, 6330, 2786, 19, 6056, 19, 2686, 3967, 13, 1930, 25783, 19730, 2687, 1958, 1925, 26848, 2116, 2115, 6319, 9573, 18, 2234, 3530, 3]}, "items": [{"id": "p_1171", "content": "Stomach Neoplasms [SEP] Tumors or cancer of the STOMACH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11399, 15347, 3, 3861, 2014, 2539, 1927, 1920, 11399, 18, 3]}]}
{"query": {"id": "q_1172", "content": "confusion [SEP] denocarcinoma. He developed acute neurologic symptoms of mental confusion, disorientation and irritability, and then lapsed into a deep c", "tokenized_content": [2, 18272, 3, 4533, 21615, 18, 2234, 3530, 3939, 14314, 3601, 1927, 5018, 18272, 16, 2054, 29292, 1930, 29534, 16, 1930, 2759, 18178, 1007, 2460, 43, 6515, 45, 3]}, "items": [{"id": "p_1172", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_1173", "content": "disorientation [SEP] ma. He developed acute neurologic symptoms of mental confusion, disorientation and irritability, and then lapsed into a deep coma, lasting for", "tokenized_content": [2, 2054, 29292, 3, 2488, 18, 2234, 3530, 3939, 14314, 3601, 1927, 5018, 18272, 16, 2054, 29292, 1930, 29534, 16, 1930, 2759, 18178, 1007, 2460, 43, 6515, 22337, 16, 11671, 1958, 3]}, "items": [{"id": "p_1173", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_1174", "content": "irritability [SEP] ute neurologic symptoms of mental confusion, disorientation and irritability, and then lapsed into a deep coma, lasting for approximately 40", "tokenized_content": [2, 29534, 3, 11112, 1021, 14314, 3601, 1927, 5018, 18272, 16, 2054, 29292, 1930, 29534, 16, 1930, 2759, 18178, 1007, 2460, 43, 6515, 22337, 16, 11671, 1958, 3993, 3040, 3]}, "items": [{"id": "p_1174", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1175", "content": "coma [SEP] n, disorientation and irritability, and then lapsed into a deep coma, lasting for approximately 40 hours during the first dose (day ", "tokenized_content": [2, 22337, 3, 56, 16, 2054, 29292, 1930, 29534, 16, 1930, 2759, 18178, 1007, 2460, 43, 6515, 22337, 16, 11671, 1958, 3993, 3040, 3967, 2409, 1920, 2561, 3253, 12, 3007, 3]}, "items": [{"id": "p_1175", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_1176", "content": "neurotoxicity [SEP] folinic acid was unlikely to be associated with this condition, neurotoxicity due to high-dose 5-fluorouracil was highly suspected. The patho", "tokenized_content": [2, 18034, 3, 25783, 19730, 2687, 1982, 8872, 1942, 1998, 2458, 1956, 2052, 2625, 16, 18034, 2810, 1942, 2149, 17, 3253, 25, 17, 21353, 1982, 3626, 9407, 18, 1920, 2450, 1037, 3]}, "items": [{"id": "p_1176", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_1177", "content": "fluoroacetate [SEP] orouracil neurotoxicity may be due to a Krebs cycle blockade by fluoroacetate and fluorocitrate, thiamine deficiency, or dihydrouracil dehydr", "tokenized_content": [2, 16191, 18007, 3, 25027, 9280, 10401, 18034, 2278, 1998, 2810, 1942, 43, 25362, 4048, 9847, 2007, 16191, 18007, 1930, 16191, 3349, 18067, 16, 26901, 6179, 16, 2014, 11842, 9280, 10401, 3]}, "items": [{"id": "p_1177", "content": "Fluoroacetates [SEP] Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and ve", "score": 1, "type": null, "tokenized_content": [2, 16191, 18007, 1036, 3, 8383, 1927, 13069, 2687, 1956, 2340, 2014, 2253, 29700, 1036, 8765, 18, 2611, 2032, 5365, 12685, 5427, 16, 4571, 1942, 4277, 13944, 16, 1930, 3428, 3]}]}
{"query": {"id": "q_1178", "content": "fluorocitrate [SEP] icity may be due to a Krebs cycle blockade by fluoroacetate and fluorocitrate, thiamine deficiency, or dihydrouracil dehydrogenase deficiency", "tokenized_content": [2, 16191, 3349, 18067, 3, 25272, 3145, 2278, 1998, 2810, 1942, 43, 25362, 4048, 9847, 2007, 16191, 18007, 1930, 16191, 3349, 18067, 16, 26901, 6179, 16, 2014, 11842, 9280, 10401, 9294, 3]}, "items": [{"id": "p_1178", "content": "fluorocitrate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16191, 3349, 18067, 3, 3]}]}
{"query": {"id": "q_1179", "content": "thiamine [SEP] e to a Krebs cycle blockade by fluoroacetate and fluorocitrate, thiamine deficiency, or dihydrouracil dehydrogenase deficiency. High-dos", "tokenized_content": [2, 26901, 3, 47, 1942, 43, 25362, 4048, 9847, 2007, 16191, 18007, 1930, 16191, 3349, 18067, 16, 26901, 6179, 16, 2014, 11842, 9280, 10401, 9294, 6179, 18, 2149, 17, 4220, 3]}, "items": [{"id": "p_1179", "content": "Thiamine [SEP] 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26901, 3, 23, 17, 12, 12, 24, 17, 3835, 17, 22, 17, 4963, 17, 25, 17, 17015, 7650, 2199, 13, 4963, 13, 17, 25, 17, 12, 22, 17, 8275, 5188, 13, 17, 24, 17, 4963, 28042, 2457, 9140, 18, 3]}]}
{"query": {"id": "q_1180", "content": "dihydrouracil [SEP] ade by fluoroacetate and fluorocitrate, thiamine deficiency, or dihydrouracil dehydrogenase deficiency. High-dose 5-fluorouracil/folinic acid", "tokenized_content": [2, 11842, 9280, 10401, 3, 23846, 2007, 16191, 18007, 1930, 16191, 3349, 18067, 16, 26901, 6179, 16, 2014, 11842, 9280, 10401, 9294, 6179, 18, 2149, 17, 3253, 25, 17, 21353, 19, 3]}, "items": [{"id": "p_1180", "content": "dihydrouracil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11842, 9280, 10401, 3, 3]}]}
{"query": {"id": "q_1181", "content": "cancers [SEP] usion therapy has recently become a popular regimen for various cancers. It is necessary that both oncologists and neurologists be full", "tokenized_content": [2, 5717, 3, 2022, 2001, 3181, 2258, 3998, 5433, 43, 11225, 8607, 1958, 3425, 5717, 18, 2176, 1977, 4680, 1988, 2321, 26757, 1930, 6155, 3535, 1998, 4125, 3]}, "items": [{"id": "p_1181", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1182", "content": "carbamazepine [SEP] Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case r", "tokenized_content": [2, 30315, 3, 2495, 1927, 10880, 30315, 1942, 2833, 15339, 7972, 6931, 12184, 1990, 1920, 3582, 2428, 1927, 20325, 17920, 1036, 18, 43, 3087, 60, 3]}, "items": [{"id": "p_1182", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_1183", "content": "oxcarbazepine [SEP] Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case report.", "tokenized_content": [2, 2833, 15339, 7972, 6931, 12184, 3, 2495, 1927, 10880, 30315, 1942, 2833, 15339, 7972, 6931, 12184, 1990, 1920, 3582, 2428, 1927, 20325, 17920, 1036, 18, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_1183", "content": "oxcarbazepine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2833, 15339, 7972, 6931, 12184, 3, 3]}]}
{"query": {"id": "q_1184", "content": "Carbamazepine [SEP] Carbamazepine was switched to its 10-keto analogue oxcarbazepine among six di", "tokenized_content": [2, 30315, 3, 30315, 1982, 15523, 1942, 2496, 2119, 17, 21471, 12980, 2833, 15339, 7972, 6931, 12184, 2706, 3798, 2137, 3]}, "items": [{"id": "p_1184", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_1185", "content": "oxcarbazepine [SEP] Carbamazepine was switched to its 10-keto analogue oxcarbazepine among six difficult-to-treat schizophrenic or organic psychotic", "tokenized_content": [2, 2833, 15339, 7972, 6931, 12184, 3, 30315, 1982, 15523, 1942, 2496, 2119, 17, 21471, 12980, 2833, 15339, 7972, 6931, 12184, 2706, 3798, 4571, 17, 1942, 17, 2297, 28247, 2014, 6805, 3]}, "items": [{"id": "p_1185", "content": "oxcarbazepine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2833, 15339, 7972, 6931, 12184, 3, 3]}]}
{"query": {"id": "q_1186", "content": "schizophrenic [SEP] its 10-keto analogue oxcarbazepine among six difficult-to-treat schizophrenic or organic psychotic patients using concomitantly haloperidol, ", "tokenized_content": [2, 28247, 3, 2496, 2119, 17, 21471, 12980, 2833, 15339, 7972, 6931, 12184, 2706, 3798, 4571, 17, 1942, 17, 2297, 28247, 2014, 6805, 16651, 2132, 2193, 19842, 25107, 16, 3]}, "items": [{"id": "p_1186", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_1187", "content": "organic psychotic [SEP] gue oxcarbazepine among six difficult-to-treat schizophrenic or organic psychotic patients using concomitantly haloperidol, chlorpromazine or clo", "tokenized_content": [2, 6805, 16651, 3, 3194, 1021, 2833, 15339, 7972, 6931, 12184, 2706, 3798, 4571, 17, 1942, 17, 2297, 28247, 2014, 6805, 16651, 2132, 2193, 19842, 25107, 16, 4891, 2216, 3368, 22030, 3]}, "items": [{"id": "p_1187", "content": "Delirium, Dementia, Amnestic, Cognitive Disorders [SEP] Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, traum", "score": 1, "type": null, "tokenized_content": [2, 18166, 16, 7811, 16, 14701, 8396, 16, 4328, 4414, 3, 4328, 4414, 2710, 18166, 16, 7811, 16, 1930, 2303, 4328, 4414, 18, 2144, 2278, 1998, 1920, 3211, 1927, 7311, 2485, 16, 5832, 3]}]}
{"query": {"id": "q_1188", "content": "haloperidol [SEP] schizophrenic or organic psychotic patients using concomitantly haloperidol, chlorpromazine or clozapine. This change resulted within 2-4 w", "tokenized_content": [2, 25107, 3, 28247, 2014, 6805, 16651, 2132, 2193, 19842, 25107, 16, 4891, 2216, 3368, 22030, 2912, 2014, 24424, 18, 2052, 3185, 4306, 2651, 22, 17, 24, 65, 3]}, "items": [{"id": "p_1188", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_1189", "content": "chlorpromazine [SEP]  or organic psychotic patients using concomitantly haloperidol, chlorpromazine or clozapine. This change resulted within 2-4 weeks in the 50-2", "tokenized_content": [2, 4891, 2216, 3368, 22030, 2912, 3, 2014, 6805, 16651, 2132, 2193, 19842, 25107, 16, 4891, 2216, 3368, 22030, 2912, 2014, 24424, 18, 2052, 3185, 4306, 2651, 22, 17, 24, 3625, 3]}, "items": [{"id": "p_1189", "content": "Chlorpromazine [SEP] The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are", "score": 1, "type": null, "tokenized_content": [2, 4891, 2216, 3368, 22030, 2912, 3, 1920, 29183, 3037, 30354, 2053, 17581, 2838, 18, 3189, 1920, 2303, 4195, 1922, 2052, 2921, 4891, 2216, 3368, 22030, 2912, 11, 61, 17581, 7728, 2032, 3]}]}
{"query": {"id": "q_1190", "content": "clozapine [SEP] tic patients using concomitantly haloperidol, chlorpromazine or clozapine. This change resulted within 2-4 weeks in the 50-200% increase ", "tokenized_content": [2, 24424, 3, 18298, 2132, 2193, 19842, 25107, 16, 4891, 2216, 3368, 22030, 2912, 2014, 24424, 18, 2052, 3185, 4306, 2651, 22, 17, 24, 3625, 1922, 1920, 2761, 17, 2191, 9, 3]}, "items": [{"id": "p_1190", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_1191", "content": "extrapyramidal symptoms [SEP] n the plasma levels of these neuroleptics and the appearance of extrapyramidal symptoms. None of the patients showed any clinical deteriotation during ", "tokenized_content": [2, 21346, 3553, 25238, 1923, 3601, 3, 56, 1920, 3582, 2428, 1927, 2144, 20325, 17920, 1036, 1930, 1920, 7818, 1927, 21346, 3553, 25238, 1923, 3601, 18, 6046, 1927, 1920, 2132, 2594, 3]}, "items": [{"id": "p_1191", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_1192", "content": "carbamazepine [SEP] ults of this case report support the idea that in contrast with carbamazepine oxcarbazepine does not induce the hepatic microsomal enzyme sys", "tokenized_content": [2, 30315, 3, 3570, 1973, 1927, 2052, 3087, 3809, 3373, 1920, 8551, 1988, 1922, 3320, 1956, 30315, 2833, 15339, 7972, 6931, 12184, 3731, 2084, 4769, 1920, 6095, 22133, 4113, 7930, 1036, 3]}, "items": [{"id": "p_1192", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_1193", "content": "Erythema multiforme [SEP] Erythema multiforme and hypersensitivity myocarditis caused by ampicillin.", "tokenized_content": [2, 23349, 15453, 2076, 1021, 3, 23349, 15453, 2076, 1021, 1930, 14625, 27169, 4189, 2007, 17128, 18, 3]}, "items": [{"id": "p_1193", "content": "Erythema Multiforme [SEP] A skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with chara", "score": 1, "type": null, "tokenized_content": [2, 23349, 15453, 2076, 1021, 3, 43, 4407, 1930, 27103, 3260, 2573, 4378, 2007, 1925, 25655, 1927, 3433, 3275, 16, 3860, 3275, 16, 12128, 16, 8319, 16, 1930, 19, 2014, 14267, 3336, 1956, 2618, 1019, 3]}]}
{"query": {"id": "q_1194", "content": "hypersensitivity myocarditis [SEP] Erythema multiforme and hypersensitivity myocarditis caused by ampicillin.", "tokenized_content": [2, 14625, 27169, 3, 23349, 15453, 2076, 1021, 1930, 14625, 27169, 4189, 2007, 17128, 18, 3]}, "items": [{"id": "p_1194", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_1195", "content": "ampicillin [SEP] Erythema multiforme and hypersensitivity myocarditis caused by ampicillin.", "tokenized_content": [2, 17128, 3, 23349, 15453, 2076, 1021, 1930, 14625, 27169, 4189, 2007, 17128, 18, 3]}, "items": [{"id": "p_1195", "content": "Ampicillin [SEP] Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17128, 3, 8762, 17, 6830, 10533, 1927, 9957, 1988, 4088, 1966, 1925, 12950, 3500, 4949, 17, 5648, 7267, 18, 3]}]}
{"query": {"id": "q_1196", "content": "erythema multiforme [SEP] OBJECTIVE: To report a case of erythema multiforme and hypersensitivity myocarditis caused by ampicillin. CASE SUM", "tokenized_content": [2, 23349, 15453, 2076, 1021, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 23349, 15453, 2076, 1021, 1930, 14625, 27169, 4189, 2007, 17128, 18, 3087, 3578, 3]}, "items": [{"id": "p_1196", "content": "Erythema Multiforme [SEP] A skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with chara", "score": 1, "type": null, "tokenized_content": [2, 23349, 15453, 2076, 1021, 3, 43, 4407, 1930, 27103, 3260, 2573, 4378, 2007, 1925, 25655, 1927, 3433, 3275, 16, 3860, 3275, 16, 12128, 16, 8319, 16, 1930, 19, 2014, 14267, 3336, 1956, 2618, 1019, 3]}]}
{"query": {"id": "q_1197", "content": "hypersensitivity myocarditis [SEP] OBJECTIVE: To report a case of erythema multiforme and hypersensitivity myocarditis caused by ampicillin. CASE SUMMARY: A 13-year-old boy was treat", "tokenized_content": [2, 14625, 27169, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 23349, 15453, 2076, 1021, 1930, 14625, 27169, 4189, 2007, 17128, 18, 3087, 6099, 30, 43, 2590, 17, 2476, 17, 4156, 3]}, "items": [{"id": "p_1197", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_1198", "content": "ampicillin [SEP]  erythema multiforme and hypersensitivity myocarditis caused by ampicillin. CASE SUMMARY: A 13-year-old boy was treated with ampicillin an", "tokenized_content": [2, 17128, 3, 23349, 15453, 2076, 1021, 1930, 14625, 27169, 4189, 2007, 17128, 18, 3087, 6099, 30, 43, 2590, 17, 2476, 17, 4156, 17914, 1982, 2868, 1956, 17128, 1925, 3]}, "items": [{"id": "p_1198", "content": "Ampicillin [SEP] Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17128, 3, 8762, 17, 6830, 10533, 1927, 9957, 1988, 4088, 1966, 1925, 12950, 3500, 4949, 17, 5648, 7267, 18, 3]}]}
{"query": {"id": "q_1199", "content": "gentamicin [SEP] CASE SUMMARY: A 13-year-old boy was treated with ampicillin and gentamicin because of suspected septicemia. Medications were discontinued ", "tokenized_content": [2, 17144, 3, 3087, 6099, 30, 43, 2590, 17, 2476, 17, 4156, 17914, 1982, 2868, 1956, 17128, 1930, 17144, 2882, 1927, 9407, 13927, 3847, 18, 7719, 1985, 16087, 3]}, "items": [{"id": "p_1199", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_1200", "content": "septicemia [SEP] was treated with ampicillin and gentamicin because of suspected septicemia. Medications were discontinued when erythema multiforme and con", "tokenized_content": [2, 13927, 3847, 3, 1982, 2868, 1956, 17128, 1930, 17144, 2882, 1927, 9407, 13927, 3847, 18, 7719, 1985, 16087, 2469, 23349, 15453, 2076, 1021, 1930, 1962, 3]}, "items": [{"id": "p_1200", "content": "Sepsis [SEP] Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dys", "score": 1, "type": null, "tokenized_content": [2, 9019, 3, 5510, 3769, 2644, 4741, 1956, 43, 9253, 2014, 9407, 7465, 10383, 18, 2469, 9019, 1977, 2458, 1956, 3090, 3890, 3]}]}
{"query": {"id": "q_1201", "content": "congestive heart failure [SEP] mia. Medications were discontinued when erythema multiforme and congestive heart failure caused by myocarditis occurred. The patient was treated with me", "tokenized_content": [2, 20180, 4003, 4574, 3, 24173, 18, 7719, 1985, 16087, 2469, 23349, 15453, 2076, 1021, 1930, 20180, 4003, 4574, 4189, 2007, 27169, 4807, 18, 1920, 2774, 1982, 2868, 1956, 2142, 3]}, "items": [{"id": "p_1201", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_1202", "content": "myocarditis [SEP] E: To report a case of erythema multiforme and hypersensitivity myocarditis caused by ampicillin. CASE SUMMARY: A 13-year-old boy was treat", "tokenized_content": [2, 27169, 3, 47, 30, 1942, 3809, 43, 3087, 1927, 23349, 15453, 2076, 1021, 1930, 14625, 27169, 4189, 2007, 17128, 18, 3087, 6099, 30, 43, 2590, 17, 2476, 17, 4156, 17914, 3]}, "items": [{"id": "p_1202", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_1203", "content": "methylprednisolone [SEP] re caused by myocarditis occurred. The patient was treated with methylprednisolone and gradually improved. Macrophage-migration inhibition (MIF) t", "tokenized_content": [2, 30087, 3, 1964, 4189, 2007, 27169, 4807, 18, 1920, 2774, 1982, 2868, 1956, 30087, 1930, 9690, 4305, 18, 8088, 17, 5049, 3523, 12, 19237, 13, 62, 3]}, "items": [{"id": "p_1203", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_1204", "content": "infections [SEP] (MIF) test with ampicillin was positive. DISCUSSION: After most infections causing erythema multiforme and myocarditis were ruled out, a d", "tokenized_content": [2, 5024, 3, 12, 19237, 13, 2648, 1956, 17128, 1982, 2843, 18, 7248, 30, 2256, 2501, 5024, 7538, 23349, 15453, 2076, 1021, 1930, 27169, 1985, 18074, 2397, 16, 43, 46, 3]}, "items": [{"id": "p_1204", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_1205", "content": "drug-induced allergic reaction [SEP] s causing erythema multiforme and myocarditis were ruled out, a drug-induced allergic reaction was suspected. Positive MIF test for ampicillin showed sensitiz", "tokenized_content": [2, 2838, 17, 2719, 10519, 3227, 3, 61, 7538, 23349, 15453, 2076, 1021, 1930, 27169, 1985, 18074, 2397, 16, 43, 2838, 17, 2719, 10519, 3227, 1982, 9407, 18, 2843, 19237, 2648, 3]}, "items": [{"id": "p_1205", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1206", "content": "Hypersensitivity myocarditis [SEP] zation of the patient's lymphocytes to ampicillin. CONCLUSIONS: Hypersensitivity myocarditis is a rare and dangerous manifestation of allergy to penicillins", "tokenized_content": [2, 14625, 27169, 3, 26112, 1929, 1927, 1920, 2774, 11, 61, 7257, 1942, 17128, 18, 4355, 30, 14625, 27169, 1977, 43, 5844, 1930, 21746, 15570, 1927, 13255, 1942, 9957, 1036, 3]}, "items": [{"id": "p_1206", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_1207", "content": "allergy [SEP] ensitivity myocarditis is a rare and dangerous manifestation of allergy to penicillins.", "tokenized_content": [2, 13255, 3, 4847, 23809, 27169, 1977, 43, 5844, 1930, 21746, 15570, 1927, 13255, 1942, 9957, 1036, 18, 3]}, "items": [{"id": "p_1207", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1208", "content": "penicillins [SEP] myocarditis is a rare and dangerous manifestation of allergy to penicillins.", "tokenized_content": [2, 9957, 1036, 3, 27169, 1977, 43, 5844, 1930, 21746, 15570, 1927, 13255, 1942, 9957, 1036, 18, 3]}, "items": [{"id": "p_1208", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_1209", "content": "allergic reactions [SEP] Immediate allergic reactions to amoxicillin.", "tokenized_content": [2, 10519, 5298, 3, 8426, 10519, 5298, 1942, 24987, 18, 3]}, "items": [{"id": "p_1209", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1210", "content": "amoxicillin [SEP] Immediate allergic reactions to amoxicillin.", "tokenized_content": [2, 24987, 3, 8426, 10519, 5298, 1942, 24987, 18, 3]}, "items": [{"id": "p_1210", "content": "Amoxicillin [SEP] A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum ", "score": 1, "type": null, "tokenized_content": [2, 24987, 3, 43, 4949, 17, 5648, 8762, 18801, 4905, 4116, 2002, 7267, 2551, 1942, 17128, 5574, 1988, 2496, 3554, 1942, 6319, 2687, 16299, 2580, 3256, 3]}]}
{"query": {"id": "q_1211", "content": "allergic reactions [SEP] A large group of patients with suspected allergic reactions to beta-lactam antibiotics was evaluated. A detailed clinical h", "tokenized_content": [2, 10519, 5298, 3, 43, 3103, 2210, 1927, 2132, 1956, 9407, 10519, 5298, 1942, 4666, 17, 15294, 7560, 1982, 3747, 18, 43, 5720, 2535, 50, 3]}, "items": [{"id": "p_1211", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1212", "content": "beta-lactam [SEP] A large group of patients with suspected allergic reactions to beta-lactam antibiotics was evaluated. A detailed clinical history, togethe", "tokenized_content": [2, 4666, 17, 15294, 3, 43, 3103, 2210, 1927, 2132, 1956, 9407, 10519, 5298, 1942, 4666, 17, 15294, 7560, 1982, 3747, 18, 43, 5720, 2535, 4403, 16, 4068, 3184, 1021, 3]}, "items": [{"id": "p_1212", "content": "beta-Lactams [SEP] Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 15294, 1036, 3, 3006, 17, 30261, 9821, 13601, 1036, 16, 4534, 3171, 1958, 1920, 9957, 1036, 2454, 1990, 43, 8876, 3143, 1037, 17, 27225, 11300, 2053, 16, 1966, 2486, 1966, 1920, 25091, 2925, 2454, 3]}]}
{"query": {"id": "q_1213", "content": "allergic [SEP] A large group of patients with suspected allergic reactions to beta-lactam antibiotics was evaluated. A detailed ", "tokenized_content": [2, 10519, 3, 43, 3103, 2210, 1927, 2132, 1956, 9407, 10519, 5298, 1942, 4666, 17, 15294, 7560, 1982, 3747, 18, 43, 5720, 3]}, "items": [{"id": "p_1213", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1214", "content": "amoxicillin [SEP] actam antibiotics had selective immediate allergic responses to amoxicillin (AX) or were cross-reacting with other penicillin derivatives. ", "tokenized_content": [2, 24987, 3, 22529, 1035, 7560, 2430, 5328, 8426, 10519, 3387, 1942, 24987, 12, 3565, 13, 2014, 1985, 3567, 17, 24181, 1956, 2303, 9957, 8383, 18, 3]}, "items": [{"id": "p_1214", "content": "Amoxicillin [SEP] A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum ", "score": 1, "type": null, "tokenized_content": [2, 24987, 3, 43, 4949, 17, 5648, 8762, 18801, 4905, 4116, 2002, 7267, 2551, 1942, 17128, 5574, 1988, 2496, 3554, 1942, 6319, 2687, 16299, 2580, 3256, 3]}]}
{"query": {"id": "q_1215", "content": "AX [SEP] tics had selective immediate allergic responses to amoxicillin (AX) or were cross-reacting with other penicillin derivatives. Skin", "tokenized_content": [2, 3565, 3, 18298, 1036, 2430, 5328, 8426, 10519, 3387, 1942, 24987, 12, 3565, 13, 2014, 1985, 3567, 17, 24181, 1956, 2303, 9957, 8383, 18, 4407, 3]}, "items": [{"id": "p_1215", "content": "Amoxicillin [SEP] A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum ", "score": 1, "type": null, "tokenized_content": [2, 24987, 3, 43, 4949, 17, 5648, 8762, 18801, 4905, 4116, 2002, 7267, 2551, 1942, 17128, 5574, 1988, 2496, 3554, 1942, 6319, 2687, 16299, 2580, 3256, 3]}]}
{"query": {"id": "q_1216", "content": "penicillin [SEP] responses to amoxicillin (AX) or were cross-reacting with other penicillin derivatives. Skin tests were performed with benzylpenicilloyl-p", "tokenized_content": [2, 9957, 3, 3387, 1942, 24987, 12, 3565, 13, 2014, 1985, 3567, 17, 24181, 1956, 2303, 9957, 8383, 18, 4407, 4026, 1985, 2593, 1956, 17605, 17125, 2478, 11560, 10921, 17, 58, 3]}, "items": [{"id": "p_1216", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_1217", "content": "benzylpenicillin [SEP]  benzylpenicilloyl-poly-L-lysine (BPO-PLL), benzylpenicilloate, benzylpenicillin (PG), ampicillin (AMP), and AX. RAST for BPO-PLL and AX-PLL was", "tokenized_content": [2, 17605, 17125, 7832, 3, 17605, 17125, 2478, 11560, 10921, 17, 4286, 17, 54, 17, 9082, 12, 4149, 1037, 17, 29817, 13, 16, 17605, 17125, 2478, 11560, 25120, 16, 17605, 17125, 3]}, "items": [{"id": "p_1217", "content": "Penicillin G [SEP] A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. ", "score": 1, "type": null, "tokenized_content": [2, 9957, 49, 3, 43, 9957, 10533, 5384, 2251, 1922, 1920, 2386, 1927, 2496, 5227, 2014, 9057, 16028, 1922, 1920, 2311, 1927, 43, 5386, 1927, 5024, 18, 3]}]}
{"query": {"id": "q_1218", "content": "PG [SEP] -poly-L-lysine (BPO-PLL), benzylpenicilloate, benzylpenicillin (PG), ampicillin (AMP), and AX. RAST for BPO-PLL and AX-PLL was don", "tokenized_content": [2, 5306, 3, 17, 4286, 17, 54, 17, 9082, 12, 4149, 1037, 17, 29817, 13, 16, 17605, 17125, 2478, 11560, 25120, 16, 17605, 17125, 7832, 12, 5306, 13, 16, 17128, 12, 3]}, "items": [{"id": "p_1218", "content": "Penicillin G [SEP] A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. ", "score": 1, "type": null, "tokenized_content": [2, 9957, 49, 3, 43, 9957, 10533, 5384, 2251, 1922, 1920, 2386, 1927, 2496, 5227, 2014, 9057, 16028, 1922, 1920, 2311, 1927, 43, 5386, 1927, 5024, 18, 3]}]}
{"query": {"id": "q_1219", "content": "ampicillin [SEP] -L-lysine (BPO-PLL), benzylpenicilloate, benzylpenicillin (PG), ampicillin (AMP), and AX. RAST for BPO-PLL and AX-PLL was done. When both ", "tokenized_content": [2, 17128, 3, 17, 54, 17, 9082, 12, 4149, 1037, 17, 29817, 13, 16, 17605, 17125, 2478, 11560, 25120, 16, 17605, 17125, 7832, 12, 5306, 13, 16, 17128, 12, 3681, 13, 3]}, "items": [{"id": "p_1219", "content": "Ampicillin [SEP] Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17128, 3, 8762, 17, 6830, 10533, 1927, 9957, 1988, 4088, 1966, 1925, 12950, 3500, 4949, 17, 5648, 7267, 18, 3]}]}
{"query": {"id": "q_1220", "content": "AMP [SEP] PO-PLL), benzylpenicilloate, benzylpenicillin (PG), ampicillin (AMP), and AX. RAST for BPO-PLL and AX-PLL was done. When both skin ", "tokenized_content": [2, 3681, 3, 2510, 17, 29817, 13, 16, 17605, 17125, 2478, 11560, 25120, 16, 17605, 17125, 7832, 12, 5306, 13, 16, 17128, 12, 3681, 13, 16, 1930, 3565, 18, 6520, 1031, 3]}, "items": [{"id": "p_1220", "content": "Ampicillin [SEP] Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17128, 3, 8762, 17, 6830, 10533, 1927, 9957, 1988, 4088, 1966, 1925, 12950, 3500, 4949, 17, 5648, 7267, 18, 3]}]}
{"query": {"id": "q_1221", "content": "allergy [SEP] m antibiotics. We selected the 54 (30.5%) cases of immediate AX allergy with good tolerance of PG. Anaphylaxis was seen in 37 patients ", "tokenized_content": [2, 13255, 3, 55, 7560, 18, 2038, 3790, 1920, 4584, 12, 2627, 18, 25, 9, 13, 2919, 1927, 8426, 3565, 13255, 1956, 4227, 6555, 1927, 5306, 18, 26726, 1982, 3945, 1922, 3]}, "items": [{"id": "p_1221", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1222", "content": "Anaphylaxis [SEP] 30.5%) cases of immediate AX allergy with good tolerance of PG. Anaphylaxis was seen in 37 patients (69%), the other 17 (31%) having urtica", "tokenized_content": [2, 26726, 3, 2627, 18, 25, 9, 13, 2919, 1927, 8426, 3565, 13255, 1956, 4227, 6555, 1927, 5306, 18, 26726, 1982, 3945, 1922, 3191, 2132, 12, 5349, 9, 13, 16, 1920, 3]}, "items": [{"id": "p_1222", "content": "Anaphylaxis [SEP] An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progres", "score": 1, "type": null, "tokenized_content": [2, 26726, 3, 1925, 3939, 14625, 3227, 2810, 1942, 3395, 1942, 43, 3024, 11989, 4730, 18, 1920, 3227, 2278, 3951, 6221, 2745, 1918, 3]}]}
{"query": {"id": "q_1223", "content": "urticaria [SEP] ylaxis was seen in 37 patients (69%), the other 17 (31%) having urticaria and/or angioedema. All the patients were skin test negative to ", "tokenized_content": [2, 27986, 6148, 3, 12111, 8665, 1982, 3945, 1922, 3191, 2132, 12, 5349, 9, 13, 16, 1920, 2303, 2752, 12, 3470, 9, 13, 4537, 27986, 6148, 1930, 19, 2014, 29220, 16670, 3]}, "items": [{"id": "p_1223", "content": "Urticaria [SEP] A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability", "score": 1, "type": null, "tokenized_content": [2, 27986, 6148, 3, 43, 4541, 3227, 1927, 1920, 4407, 4378, 2007, 23349, 1930, 8372, 1923, 3337, 2810, 1942, 6579, 2760, 1927, 4541, 8828, 3]}]}
{"query": {"id": "q_1224", "content": "angioedema [SEP] n 37 patients (69%), the other 17 (31%) having urticaria and/or angioedema. All the patients were skin test negative to BPO; 49 of 51 (96%", "tokenized_content": [2, 29220, 16670, 3, 56, 3191, 2132, 12, 5349, 9, 13, 16, 1920, 2303, 2752, 12, 3470, 9, 13, 4537, 27986, 6148, 1930, 19, 2014, 29220, 16670, 18, 2136, 1920, 2132, 3]}, "items": [{"id": "p_1224", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_1225", "content": "MDM [SEP] skin test negative to BPO; 49 of 51 (96%) were also negative to MDM, and 44 of 46 (96%) to PG. Skin tests with AX were positive in ", "tokenized_content": [2, 21030, 3, 4407, 2648, 3136, 1942, 4149, 1037, 31, 4343, 1927, 4892, 12, 4746, 9, 13, 1985, 2222, 3136, 1942, 21030, 16, 1930, 4044, 1927, 4182, 12, 4746, 9, 13, 3]}, "items": [{"id": "p_1225", "content": "Keratoderma, Palmoplantar [SEP] Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formati", "score": 1, "type": null, "tokenized_content": [2, 16047, 20532, 16, 15516, 3513, 23200, 1005, 3, 2210, 1927, 6969, 16321, 4414, 4378, 2007, 16121, 1927, 1920, 15516, 1036, 1930, 12168, 1036, 1966, 43, 3211, 1927, 9122, 9743, 10387, 1033, 3]}]}
{"query": {"id": "q_1226", "content": "allergic reaction [SEP] A large group of patients with suspected allergic reactions to beta-lactam antibiotics was evaluated. A detailed clinical ", "tokenized_content": [2, 10519, 3227, 3, 43, 3103, 2210, 1927, 2132, 1956, 9407, 10519, 5298, 1942, 4666, 17, 15294, 7560, 1982, 3747, 18, 43, 5720, 2535, 3]}, "items": [{"id": "p_1226", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1227", "content": "paralysis [SEP] Persistent paralysis after prolonged use of atracurium in the absence of corticoster", "tokenized_content": [2, 18973, 3, 7733, 18973, 2256, 7171, 2485, 1927, 20319, 18021, 3027, 1989, 1922, 1920, 3905, 1927, 11495, 3]}, "items": [{"id": "p_1227", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_1228", "content": "atracurium [SEP] Persistent paralysis after prolonged use of atracurium in the absence of corticosteroids.", "tokenized_content": [2, 20319, 18021, 3027, 1989, 3, 7733, 18973, 2256, 7171, 2485, 1927, 20319, 18021, 3027, 1989, 1922, 1920, 3905, 1927, 14610, 18, 3]}, "items": [{"id": "p_1228", "content": "Atracurium [SEP] A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects an", "score": 1, "type": null, "tokenized_content": [2, 20319, 18021, 3027, 1989, 3, 43, 2447, 17, 24999, 15829, 7472, 5899, 1956, 3662, 4392, 1927, 4615, 18, 2496, 3630, 1927, 2228, 5321, 2564, 1925, 3]}]}
{"query": {"id": "q_1229", "content": "paralysis [SEP] quiring prolonged mechanical ventilation. Reports of persistent paralysis after the discontinuance of these drugs have most often involve", "tokenized_content": [2, 18973, 3, 2571, 7704, 7171, 5821, 10198, 18, 4710, 1927, 7733, 18973, 2256, 1920, 9035, 13785, 1972, 1927, 2144, 4195, 2162, 2501, 3868, 8156, 3]}, "items": [{"id": "p_1229", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_1230", "content": "vecuronium bromide [SEP] drugs have most often involved aminosteroid-based NMBAs such as vecuronium bromide, especially when used in conjunction with corticosteroids. Atra", "tokenized_content": [2, 28054, 10366, 2457, 13788, 3, 4195, 2162, 2501, 3868, 3286, 3835, 2156, 6506, 1960, 17, 2454, 2943, 7972, 1036, 2427, 1966, 28054, 10366, 2457, 13788, 16, 4369, 2469, 2251, 1922, 3]}, "items": [{"id": "p_1230", "content": "Vecuronium Bromide [SEP] Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than panc", "score": 1, "type": null, "tokenized_content": [2, 28054, 10366, 2457, 13788, 3, 8914, 28273, 1915, 14203, 5928, 1927, 5001, 10366, 2457, 18, 43, 2447, 17, 24999, 15829, 7472, 5899, 1956, 7310, 4392, 1927, 4615, 2254, 5001, 3]}]}
{"query": {"id": "q_1231", "content": "Atracurium besylate [SEP] mide, especially when used in conjunction with corticosteroids. Atracurium besylate, a short-acting benzylisoquinolinium NMBA that is eliminated in", "tokenized_content": [2, 20319, 18021, 3027, 1989, 7968, 9075, 3, 3953, 1021, 16, 4369, 2469, 2251, 1922, 11799, 1956, 14610, 18, 20319, 18021, 3027, 1989, 7968, 9075, 16, 43, 3662, 17, 8290, 17605, 3]}, "items": [{"id": "p_1231", "content": "Atracurium [SEP] A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects an", "score": 1, "type": null, "tokenized_content": [2, 20319, 18021, 3027, 1989, 3, 43, 2447, 17, 24999, 15829, 7472, 5899, 1956, 3662, 4392, 1927, 4615, 18, 2496, 3630, 1927, 2228, 5321, 2564, 1925, 3]}]}
{"query": {"id": "q_1232", "content": "atracurium [SEP] s, but only when used with corticosteroids. We report a case of atracurium-related paralysis persisting for approximately 50 hours in a pa", "tokenized_content": [2, 20319, 18021, 3027, 1989, 3, 61, 16, 2308, 2444, 2469, 2251, 1956, 14610, 18, 2038, 3809, 43, 3087, 1927, 20319, 18021, 3027, 1989, 17, 2712, 18973, 26014, 1958, 3993, 2761, 3]}, "items": [{"id": "p_1232", "content": "Atracurium [SEP] A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects an", "score": 1, "type": null, "tokenized_content": [2, 20319, 18021, 3027, 1989, 3, 43, 2447, 17, 24999, 15829, 7472, 5899, 1956, 3662, 4392, 1927, 4615, 18, 2496, 3630, 1927, 2228, 5321, 2564, 1925, 3]}]}
{"query": {"id": "q_1233", "content": "acetaminophen [SEP] Habitual use of acetaminophen as a risk factor for chronic renal failure: a comparison with p", "tokenized_content": [2, 23311, 3, 23427, 2485, 1927, 23311, 1966, 43, 2565, 2991, 1958, 3724, 4604, 4574, 30, 43, 3723, 1956, 58, 3]}, "items": [{"id": "p_1233", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_1234", "content": "chronic renal failure [SEP] Habitual use of acetaminophen as a risk factor for chronic renal failure: a comparison with phenacetin.", "tokenized_content": [2, 3724, 4604, 4574, 3, 23427, 2485, 1927, 23311, 1966, 43, 2565, 2991, 1958, 3724, 4604, 4574, 30, 43, 3723, 1956, 3037, 7681, 1921, 18, 3]}, "items": [{"id": "p_1234", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_1235", "content": "phenacetin [SEP] n as a risk factor for chronic renal failure: a comparison with phenacetin.", "tokenized_content": [2, 3037, 7681, 1921, 3, 56, 1966, 43, 2565, 2991, 1958, 3724, 4604, 4574, 30, 43, 3723, 1956, 3037, 7681, 1921, 18, 3]}, "items": [{"id": "p_1235", "content": "Phenacetin [SEP] A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the mark", "score": 1, "type": null, "tokenized_content": [2, 3037, 7681, 1921, 3, 43, 7971, 27457, 1988, 1982, 22397, 2251, 1922, 21863, 2308, 15582, 1930, 2295, 1987, 7856, 3847, 4866, 1942, 2496, 9594, 2037, 1920, 2937, 3]}]}
{"query": {"id": "q_1236", "content": "phenacetin [SEP] s in the United States and Europe indicate that habitual use of phenacetin is associated with the development of chronic renal failure and", "tokenized_content": [2, 3037, 7681, 1921, 3, 61, 1922, 1920, 6128, 4376, 1930, 5560, 3579, 1988, 23427, 2485, 1927, 3037, 7681, 1921, 1977, 2458, 1956, 1920, 2740, 1927, 3724, 4604, 4574, 1930, 3]}, "items": [{"id": "p_1236", "content": "Phenacetin [SEP] A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the mark", "score": 1, "type": null, "tokenized_content": [2, 3037, 7681, 1921, 3, 43, 7971, 27457, 1988, 1982, 22397, 2251, 1922, 21863, 2308, 15582, 1930, 2295, 1987, 7856, 3847, 4866, 1942, 2496, 9594, 2037, 1920, 2937, 3]}]}
{"query": {"id": "q_1237", "content": "chronic renal failure [SEP] abitual use of phenacetin is associated with the development of chronic renal failure and end-stage renal disease (ESRD), with a relative risk in the", "tokenized_content": [2, 3724, 4604, 4574, 3, 13127, 1031, 2224, 2485, 1927, 3037, 7681, 1921, 1977, 2458, 1956, 1920, 2740, 1927, 3724, 4604, 4574, 1930, 2482, 17, 3587, 4604, 2573, 12, 17070, 13, 3]}, "items": [{"id": "p_1237", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_1238", "content": "end-stage renal disease [SEP] is associated with the development of chronic renal failure and end-stage renal disease (ESRD), with a relative risk in the range of 4 to 19. As a resu", "tokenized_content": [2, 2482, 17, 3587, 4604, 2573, 3, 1977, 2458, 1956, 1920, 2740, 1927, 3724, 4604, 4574, 1930, 2482, 17, 3587, 4604, 2573, 12, 17070, 13, 16, 1956, 43, 3338, 2565, 1922, 3]}, "items": [{"id": "p_1238", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_1239", "content": "ESRD [SEP] velopment of chronic renal failure and end-stage renal disease (ESRD), with a relative risk in the range of 4 to 19. As a result of ", "tokenized_content": [2, 17070, 3, 6217, 2011, 2017, 1927, 3724, 4604, 4574, 1930, 2482, 17, 3587, 4604, 2573, 12, 17070, 13, 16, 1956, 43, 3338, 2565, 1922, 1920, 3109, 1927, 24, 1942, 2282, 3]}, "items": [{"id": "p_1239", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_1240", "content": "acetaminophen [SEP] Maryland, and West Berlin, Germany, showed that habitual use of acetaminophen is also associated with chronic renal failure and ESRD, with a ", "tokenized_content": [2, 23311, 3, 24975, 16, 1930, 9195, 22577, 16, 6205, 16, 2594, 1988, 23427, 2485, 1927, 23311, 1977, 2222, 2458, 1956, 3724, 4604, 4574, 1930, 17070, 16, 1956, 43, 3]}, "items": [{"id": "p_1240", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_1241", "content": "nephrotoxic [SEP] is apparent difference in risk may not be due to differences in nephrotoxic potential of the drugs themselves. A lower relative risk would ", "tokenized_content": [2, 22994, 10605, 3, 1977, 6273, 3175, 1922, 2565, 2278, 2084, 1998, 2810, 1942, 2886, 1922, 22994, 10605, 2889, 1927, 1920, 4195, 8569, 18, 43, 2826, 3338, 2565, 2962, 3]}, "items": [{"id": "p_1241", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1242", "content": "heparan sulphate [SEP] Reduction of heparan sulphate-associated anionic sites in the glomerular basement membrane of", "tokenized_content": [2, 22024, 20415, 3, 3378, 1927, 22024, 20415, 17, 2458, 19696, 3402, 1922, 1920, 11655, 16702, 3260, 1927, 3]}, "items": [{"id": "p_1242", "content": "Heparitin Sulfate [SEP] A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3357, 2205, 2268, 8767, 3, 43, 19732, 13811, 2012, 9466, 1988, 1977, 2551, 1922, 3170, 1942, 9962, 18, 2176, 18804, 1922, 3445, 1956, 3422, 13580, 7364, 15072, 8362, 18, 3]}]}
{"query": {"id": "q_1243", "content": "streptozotocin [SEP]  anionic sites in the glomerular basement membrane of rats with streptozotocin-induced diabetic nephropathy.", "tokenized_content": [2, 26492, 3, 19696, 3402, 1922, 1920, 11655, 16702, 3260, 1927, 3615, 1956, 26492, 17, 2719, 6152, 15582, 18, 3]}, "items": [{"id": "p_1243", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_1244", "content": "diabetic nephropathy [SEP] lomerular basement membrane of rats with streptozotocin-induced diabetic nephropathy.", "tokenized_content": [2, 6152, 15582, 3, 3004, 9213, 2168, 16702, 3260, 1927, 3615, 1956, 26492, 17, 2719, 6152, 15582, 18, 3]}, "items": [{"id": "p_1244", "content": "Diabetic Nephropathies [SEP] KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstit", "score": 1, "type": null, "tokenized_content": [2, 6152, 7737, 7262, 2062, 3, 5245, 8209, 2458, 1956, 4032, 9695, 1930, 7359, 5245, 19268, 1957, 31, 24332, 31, 5245, 14876, 31, 1930, 1920, 10918, 1031, 3]}]}
{"query": {"id": "q_1245", "content": "Heparan sulphate [SEP] Heparan sulphate-associated anionic sites in the glomerular basement membrane we", "tokenized_content": [2, 22024, 20415, 3, 22024, 20415, 17, 2458, 19696, 3402, 1922, 1920, 11655, 16702, 3260, 2038, 3]}, "items": [{"id": "p_1245", "content": "Heparitin Sulfate [SEP] A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3357, 2205, 2268, 8767, 3, 43, 19732, 13811, 2012, 9466, 1988, 1977, 2551, 1922, 3170, 1942, 9962, 18, 2176, 18804, 1922, 3445, 1956, 3422, 13580, 7364, 15072, 8362, 18, 3]}]}
{"query": {"id": "q_1246", "content": "diabetes [SEP] ement membrane were studied in rats 8 months after induction of diabetes by streptozotocin and in age- adn sex-matched control rats, emp", "tokenized_content": [2, 4032, 3, 2391, 1939, 3260, 1985, 3942, 1922, 3615, 28, 3221, 2256, 4408, 1927, 4032, 2007, 26492, 1930, 1922, 2632, 17, 2041, 1022, 3486, 17, 5992, 2285, 3615, 16, 6467, 3]}, "items": [{"id": "p_1246", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_1247", "content": "streptozotocin [SEP] ne were studied in rats 8 months after induction of diabetes by streptozotocin and in age- adn sex-matched control rats, employing the cationi", "tokenized_content": [2, 26492, 3, 2069, 1985, 3942, 1922, 3615, 28, 3221, 2256, 4408, 1927, 4032, 2007, 26492, 1930, 1922, 2632, 17, 2041, 1022, 3486, 17, 5992, 2285, 3615, 16, 12003, 1920, 9976, 3]}, "items": [{"id": "p_1247", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_1248", "content": "cuprolinic blue [SEP] n age- adn sex-matched control rats, employing the cationic dye cuprolinic blue. Morphometric analysis at the ultrastructural level was perform", "tokenized_content": [2, 14967, 2226, 26386, 4735, 3, 56, 2632, 17, 2041, 1022, 3486, 17, 5992, 2285, 3615, 16, 12003, 1920, 15175, 8347, 14967, 2226, 26386, 4735, 18, 21170, 2333, 2019, 1920, 19352, 3]}, "items": [{"id": "p_1248", "content": "copper phthalocyanine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9541, 19686, 29193, 3, 3]}]}
{"query": {"id": "q_1249", "content": "heparan sulphate [SEP] l level was performed using a computerized image processor. The heparan sulphate specificity of the cuprolinic blue staining was demonstrated by", "tokenized_content": [2, 22024, 20415, 3, 54, 2237, 1982, 2593, 2193, 43, 17206, 4029, 28878, 18, 1920, 22024, 20415, 4896, 1927, 1920, 14967, 2226, 26386, 4735, 4166, 1982, 3161, 2007, 3]}, "items": [{"id": "p_1249", "content": "Heparitin Sulfate [SEP] A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3357, 2205, 2268, 8767, 3, 43, 19732, 13811, 2012, 9466, 1988, 1977, 2551, 1922, 3170, 1942, 9962, 18, 2176, 18804, 1922, 3445, 1956, 3422, 13580, 7364, 15072, 8362, 18, 3]}]}
{"query": {"id": "q_1250", "content": "glycosaminoglycan [SEP] specificity of the cuprolinic blue staining was demonstrated by glycosaminoglycan-degrading enzymes, showing that pretreatment of the sections wi", "tokenized_content": [2, 25982, 15391, 3, 4896, 1927, 1920, 14967, 2226, 26386, 4735, 4166, 1982, 3161, 2007, 25982, 15391, 17, 18192, 5038, 16, 4570, 1988, 9111, 1927, 1920, 4828, 11980, 3]}, "items": [{"id": "p_1250", "content": "Glycosaminoglycans [SEP] Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating st", "score": 1, "type": null, "tokenized_content": [2, 25982, 19900, 3, 19732, 13811, 2012, 11926, 2154, 5531, 1925, 56, 17, 16360, 7142, 17454, 1922, 43, 6293, 21763, 2054, 9466, 5344, 18, 1920, 21763, 1955, 3]}]}
{"query": {"id": "q_1251", "content": "diabetic [SEP] tinase ABC had no effect. The majority of anionic sites (74% in diabetic and 81% in control rats) were found within the lamina rara exte", "tokenized_content": [2, 6152, 3, 12347, 2051, 7219, 2430, 2239, 2495, 18, 1920, 4827, 1927, 19696, 3402, 12, 5446, 9, 1922, 6152, 1930, 6206, 9, 1922, 2285, 3615, 13, 1985, 2435, 2651, 1920, 3]}, "items": [{"id": "p_1251", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_1252", "content": "Diabetic [SEP] <0.001 and p<0.01 for diabetic and control rats, respectively). Diabetic rats progressively developed albuminuria reaching 40.3 (32.2-62", "tokenized_content": [2, 6152, 3, 32, 20, 18, 3472, 1930, 58, 32, 20, 18, 3287, 1958, 6152, 1930, 2285, 3615, 16, 2763, 13, 18, 6152, 3615, 13264, 3530, 24962, 9834, 3040, 18, 23, 3]}, "items": [{"id": "p_1252", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_1253", "content": "albuminuria [SEP] trol rats, respectively). Diabetic rats progressively developed albuminuria reaching 40.3 (32.2-62.0) mg/24 h after 8 months in contrast to", "tokenized_content": [2, 24962, 3, 12730, 1024, 3615, 16, 2763, 13, 18, 6152, 3615, 13264, 3530, 24962, 9834, 3040, 18, 23, 12, 3323, 18, 22, 17, 5374, 18, 20, 13, 2786, 19, 2686, 3]}, "items": [{"id": "p_1253", "content": "Albuminuria [SEP] The presence of albumin in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24962, 3, 1920, 2990, 1927, 7712, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_1254", "content": "renal toxicity [SEP] Effect of some anticancer drugs and combined chemotherapy on renal toxicity.", "tokenized_content": [2, 4604, 5532, 3, 2495, 1927, 2673, 11515, 4195, 1930, 4252, 5318, 1990, 4604, 5532, 18, 3]}, "items": [{"id": "p_1254", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1255", "content": "nephrotoxic [SEP] The nephrotoxic action of anticancer drugs such as nitrogranulogen (NG), methot", "tokenized_content": [2, 22994, 10605, 3, 1920, 22994, 10605, 4615, 1927, 11515, 4195, 2427, 1966, 8686, 18218, 1944, 2404, 12, 4375, 13, 16, 17996, 3]}, "items": [{"id": "p_1255", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1256", "content": "nitrogranulogen [SEP] The nephrotoxic action of anticancer drugs such as nitrogranulogen (NG), methotrexate (MTX), 5-fluorouracil (5-FU) and cyclophosph", "tokenized_content": [2, 8686, 18218, 1944, 2404, 3, 1920, 22994, 10605, 4615, 1927, 11515, 4195, 2427, 1966, 8686, 18218, 1944, 2404, 12, 4375, 13, 16, 18031, 12, 15463, 13, 16, 25, 17, 21353, 3]}, "items": [{"id": "p_1256", "content": "Mechlorethamine [SEP] A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is use", "score": 1, "type": null, "tokenized_content": [2, 10685, 7806, 2073, 1963, 3812, 3, 43, 5634, 13611, 1031, 1930, 27438, 5262, 8108, 21243, 1942, 27103, 5726, 18, 2176, 1982, 22397, 2251, 1966, 43, 8200, 4422, 18, 1920, 16675, 1977, 2485, 3]}]}
{"query": {"id": "q_1257", "content": "NG [SEP] nephrotoxic action of anticancer drugs such as nitrogranulogen (NG), methotrexate (MTX), 5-fluorouracil (5-FU) and cyclophosphamid", "tokenized_content": [2, 4375, 3, 22994, 10605, 4615, 1927, 11515, 4195, 2427, 1966, 8686, 18218, 1944, 2404, 12, 4375, 13, 16, 18031, 12, 15463, 13, 16, 25, 17, 21353, 12, 25, 17, 7391, 3]}, "items": [{"id": "p_1257", "content": "Mechlorethamine [SEP] A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is use", "score": 1, "type": null, "tokenized_content": [2, 10685, 7806, 2073, 1963, 3812, 3, 43, 5634, 13611, 1031, 1930, 27438, 5262, 8108, 21243, 1942, 27103, 5726, 18, 2176, 1982, 22397, 2251, 1966, 43, 8200, 4422, 18, 1920, 16675, 1977, 2485, 3]}]}
{"query": {"id": "q_1258", "content": "methotrexate [SEP] otoxic action of anticancer drugs such as nitrogranulogen (NG), methotrexate (MTX), 5-fluorouracil (5-FU) and cyclophosphamide (CY) administ", "tokenized_content": [2, 18031, 3, 7608, 10605, 4615, 1927, 11515, 4195, 2427, 1966, 8686, 18218, 1944, 2404, 12, 4375, 13, 16, 18031, 12, 15463, 13, 16, 25, 17, 21353, 12, 25, 17, 7391, 3]}, "items": [{"id": "p_1258", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_1259", "content": "MTX [SEP] of anticancer drugs such as nitrogranulogen (NG), methotrexate (MTX), 5-fluorouracil (5-FU) and cyclophosphamide (CY) administered ", "tokenized_content": [2, 15463, 3, 1927, 11515, 4195, 2427, 1966, 8686, 18218, 1944, 2404, 12, 4375, 13, 16, 18031, 12, 15463, 13, 16, 25, 17, 21353, 12, 25, 17, 7391, 13, 1930, 17135, 3]}, "items": [{"id": "p_1259", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_1260", "content": "5-fluorouracil [SEP] icancer drugs such as nitrogranulogen (NG), methotrexate (MTX), 5-fluorouracil (5-FU) and cyclophosphamide (CY) administered alone or in combi", "tokenized_content": [2, 25, 17, 21353, 3, 14784, 15895, 1915, 4195, 2427, 1966, 8686, 18218, 1944, 2404, 12, 4375, 13, 16, 18031, 12, 15463, 13, 16, 25, 17, 21353, 12, 25, 17, 7391, 3]}, "items": [{"id": "p_1260", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1261", "content": "5-FU [SEP] ch as nitrogranulogen (NG), methotrexate (MTX), 5-fluorouracil (5-FU) and cyclophosphamide (CY) administered alone or in combination", "tokenized_content": [2, 25, 17, 7391, 3, 2016, 1966, 8686, 18218, 1944, 2404, 12, 4375, 13, 16, 18031, 12, 15463, 13, 16, 25, 17, 21353, 12, 25, 17, 7391, 13, 1930, 17135, 12, 3]}, "items": [{"id": "p_1261", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1262", "content": "cyclophosphamide [SEP] ogranulogen (NG), methotrexate (MTX), 5-fluorouracil (5-FU) and cyclophosphamide (CY) administered alone or in combination [MTX + 5-FU + CY (CMF", "tokenized_content": [2, 17135, 3, 17395, 17182, 1944, 2404, 12, 4375, 13, 16, 18031, 12, 15463, 13, 16, 25, 17, 21353, 12, 25, 17, 7391, 13, 1930, 17135, 12, 6002, 13, 5254, 4298, 3]}, "items": [{"id": "p_1262", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_1263", "content": "CY [SEP] methotrexate (MTX), 5-fluorouracil (5-FU) and cyclophosphamide (CY) administered alone or in combination [MTX + 5-FU + CY (CMF)] w", "tokenized_content": [2, 6002, 3, 18031, 12, 15463, 13, 16, 25, 17, 21353, 12, 25, 17, 7391, 13, 1930, 17135, 12, 6002, 13, 5254, 4298, 2014, 1922, 3921, 37, 15463, 15, 25, 17, 3]}, "items": [{"id": "p_1263", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_1264", "content": "creatinine [SEP] uated in experiments on Wistar rats. After drug administration, creatinine concentrations in the plasma and in the urine of the rats were ", "tokenized_content": [2, 9374, 3, 17942, 2013, 1922, 3144, 1990, 15668, 3615, 18, 2256, 2838, 4183, 16, 9374, 3295, 1922, 1920, 3582, 1930, 1922, 1920, 6960, 1927, 1920, 3615, 1985, 3]}, "items": [{"id": "p_1264", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_1265", "content": "hemorrhagic [SEP]  did not increase significantly compared to controls. CY caused hemorrhagic cystitis in 40% of rats, but it did not cause this complication", "tokenized_content": [2, 16052, 3, 2811, 2084, 2760, 2567, 2452, 1942, 3562, 18, 6002, 4189, 16052, 9446, 3678, 1922, 3040, 9, 1927, 3615, 16, 2308, 2176, 2811, 2084, 3936, 2052, 9388, 3]}, "items": [{"id": "p_1265", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_1266", "content": "cystitis [SEP] rease significantly compared to controls. CY caused hemorrhagic cystitis in 40% of rats, but it did not cause this complication when com", "tokenized_content": [2, 9446, 3678, 3, 4196, 1021, 2567, 2452, 1942, 3562, 18, 6002, 4189, 16052, 9446, 3678, 1922, 3040, 9, 1927, 3615, 16, 2308, 2176, 2811, 2084, 3936, 2052, 9388, 2469, 2008, 3]}, "items": [{"id": "p_1266", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_1267", "content": "nephrotoxicity [SEP] MTX + 5-FU + CY compared to controls. Our studies indicate that nephrotoxicity of MTX + 5-FU + CY administered jointly is lower than in monoth", "tokenized_content": [2, 27880, 3, 15463, 15, 25, 17, 7391, 15, 6002, 2452, 1942, 3562, 18, 2342, 2351, 3579, 1988, 27880, 1927, 15463, 15, 25, 17, 7391, 15, 6002, 5254, 20967, 1977, 2826, 3]}, "items": [{"id": "p_1267", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1268", "content": "Lithium [SEP] Lithium-associated cognitive and functional deficits reduced by a switc", "tokenized_content": [2, 14330, 3, 14330, 17, 2458, 4328, 1930, 3183, 7961, 3028, 2007, 43, 19532, 6916, 3]}, "items": [{"id": "p_1268", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_1269", "content": "cognitive and functional deficits [SEP] Lithium-associated cognitive and functional deficits reduced by a switch to divalproex sodium: a case series.", "tokenized_content": [2, 4328, 1930, 3183, 7961, 3, 14330, 17, 2458, 4328, 1930, 3183, 7961, 3028, 2007, 43, 6195, 1942, 6421, 1923, 2216, 2783, 5227, 30, 43, 3087, 4696, 18, 3]}, "items": [{"id": "p_1269", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_1270", "content": "divalproex sodium [SEP] ciated cognitive and functional deficits reduced by a switch to divalproex sodium: a case series.", "tokenized_content": [2, 6421, 1923, 2216, 2783, 5227, 3, 24748, 2013, 4328, 1930, 3183, 7961, 3028, 2007, 43, 6195, 1942, 6421, 1923, 2216, 2783, 5227, 30, 43, 3087, 4696, 18, 3]}, "items": [{"id": "p_1270", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1271", "content": "Lithium [SEP] BACKGROUND: Lithium remains a first-line treatment for the acute and maintenance tr", "tokenized_content": [2, 14330, 3, 3872, 30, 14330, 4497, 43, 2561, 17, 2823, 2311, 1958, 1920, 3939, 1930, 6291, 2025, 3]}, "items": [{"id": "p_1271", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_1272", "content": "bipolar disorder [SEP] first-line treatment for the acute and maintenance treatment of bipolar disorder. Although much has been written about the management of the mor", "tokenized_content": [2, 10275, 4770, 3, 2561, 17, 2823, 2311, 1958, 1920, 3939, 1930, 6291, 2311, 1927, 10275, 4770, 18, 2876, 4186, 2258, 2252, 7288, 3001, 1920, 4280, 1927, 1920, 2803, 3]}, "items": [{"id": "p_1272", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_1273", "content": "lithium [SEP] tten about the management of the more common adverse effects of lithium, such as polyuria and tremor, more subtle lithium side effects ", "tokenized_content": [2, 14330, 3, 7382, 1917, 3001, 1920, 4280, 1927, 1920, 2253, 3059, 5246, 2564, 1927, 14330, 16, 2427, 1966, 4286, 8754, 1930, 18388, 16, 2253, 12842, 14330, 4159, 2564, 3]}, "items": [{"id": "p_1273", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_1274", "content": "polyuria [SEP] nagement of the more common adverse effects of lithium, such as polyuria and tremor, more subtle lithium side effects such as cognitive ", "tokenized_content": [2, 4286, 8754, 3, 14466, 2855, 1927, 1920, 2253, 3059, 5246, 2564, 1927, 14330, 16, 2427, 1966, 4286, 8754, 1930, 18388, 16, 2253, 12842, 14330, 4159, 2564, 2427, 1966, 4328, 3]}, "items": [{"id": "p_1274", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_1275", "content": "tremor [SEP] he more common adverse effects of lithium, such as polyuria and tremor, more subtle lithium side effects such as cognitive deficits, l", "tokenized_content": [2, 18388, 3, 2234, 2253, 3059, 5246, 2564, 1927, 14330, 16, 2427, 1966, 4286, 8754, 1930, 18388, 16, 2253, 12842, 14330, 4159, 2564, 2427, 1966, 4328, 7961, 16, 54, 3]}, "items": [{"id": "p_1275", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_1276", "content": "cognitive deficits [SEP] s polyuria and tremor, more subtle lithium side effects such as cognitive deficits, loss of creativity, and functional impairments remain understu", "tokenized_content": [2, 4328, 7961, 3, 61, 4286, 8754, 1930, 18388, 16, 2253, 12842, 14330, 4159, 2564, 2427, 1966, 4328, 7961, 16, 3257, 1927, 3478, 13778, 16, 1930, 3183, 12454, 5555, 4606, 1032, 3]}, "items": [{"id": "p_1276", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_1277", "content": "loss of creativity [SEP] r, more subtle lithium side effects such as cognitive deficits, loss of creativity, and functional impairments remain understudied. This report su", "tokenized_content": [2, 3257, 1927, 3478, 13778, 3, 60, 16, 2253, 12842, 14330, 4159, 2564, 2427, 1966, 4328, 7961, 16, 3257, 1927, 3478, 13778, 16, 1930, 3183, 12454, 5555, 4606, 16698, 1919, 18, 3]}, "items": [{"id": "p_1277", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_1278", "content": "functional impairments [SEP] ide effects such as cognitive deficits, loss of creativity, and functional impairments remain understudied. This report summarizes our experience in s", "tokenized_content": [2, 3183, 12454, 3, 9043, 2564, 2427, 1966, 4328, 7961, 16, 3257, 1927, 3478, 13778, 16, 1930, 3183, 12454, 5555, 4606, 16698, 1919, 18, 2052, 3809, 14934, 2342, 4848, 1922, 61, 3]}, "items": [{"id": "p_1278", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_1279", "content": "bipolar [SEP] first-line treatment for the acute and maintenance treatment of bipolar disorder. Although much has been written about the management o", "tokenized_content": [2, 10275, 3, 2561, 17, 2823, 2311, 1958, 1920, 3939, 1930, 6291, 2311, 1927, 10275, 4770, 18, 2876, 4186, 2258, 2252, 7288, 3001, 1920, 4280, 57, 3]}, "items": [{"id": "p_1279", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_1280", "content": "divalproex sodium [SEP] es our experience in switching bipolar patients from lithium to divalproex sodium to alleviate such cognitive and functional impairments. METHOD:", "tokenized_content": [2, 6421, 1923, 2216, 2783, 5227, 3, 2376, 2342, 4848, 1922, 10880, 10275, 2132, 2037, 14330, 1942, 6421, 1923, 2216, 2783, 5227, 1942, 18312, 2427, 4328, 1930, 3183, 12454, 18, 2417, 3]}, "items": [{"id": "p_1280", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1281", "content": "cognitive and functional impairments [SEP] ar patients from lithium to divalproex sodium to alleviate such cognitive and functional impairments. METHOD: Open, case series design. RESULTS: We report seven cas", "tokenized_content": [2, 4328, 1930, 3183, 12454, 3, 2245, 2132, 2037, 14330, 1942, 6421, 1923, 2216, 2783, 5227, 1942, 18312, 2427, 4328, 1930, 3183, 12454, 18, 2417, 30, 4437, 16, 3087, 4696, 3036, 3]}, "items": [{"id": "p_1281", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_1282", "content": "cognitive, motivational, or creative deficits [SEP] y, with divalproex sodium was extremely helpful in reducing the cognitive, motivational, or creative deficits attributed to lithium in our bipolar patients. CONCLUSION: In t", "tokenized_content": [2, 4328, 16, 17590, 16, 2014, 21093, 7961, 3, 67, 16, 1956, 6421, 1923, 2216, 2783, 5227, 1982, 8113, 9617, 1922, 5526, 1920, 4328, 16, 17590, 16, 2014, 21093, 7961, 6898, 3]}, "items": [{"id": "p_1282", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_1283", "content": "breast cancer [SEP] Treatment of previously treated metastatic breast cancer by mitoxantrone and 48-hour continuous infusion of high-dose 5-", "tokenized_content": [2, 3739, 2539, 3, 2311, 1927, 3024, 2868, 6476, 3739, 2539, 2007, 25959, 11414, 4905, 2830, 1021, 1930, 3427, 17, 6231, 4798, 7386, 1927, 2149, 17, 3253, 25, 17, 3]}, "items": [{"id": "p_1283", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_1284", "content": "mitoxantrone [SEP] Treatment of previously treated metastatic breast cancer by mitoxantrone and 48-hour continuous infusion of high-dose 5-FU and leucovori", "tokenized_content": [2, 25959, 11414, 4905, 2830, 1021, 3, 2311, 1927, 3024, 2868, 6476, 3739, 2539, 2007, 25959, 11414, 4905, 2830, 1021, 1930, 3427, 17, 6231, 4798, 7386, 1927, 2149, 17, 3253, 25, 3]}, "items": [{"id": "p_1284", "content": "Mitoxantrone [SEP] An anthracenedione-derived antineoplastic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25959, 11414, 4905, 2830, 1021, 3, 1925, 19657, 20670, 2290, 17, 3595, 29128, 9969, 5899, 18, 3]}]}
{"query": {"id": "q_1285", "content": "5-FU [SEP] er by mitoxantrone and 48-hour continuous infusion of high-dose 5-FU and leucovorin (MFL): low palliative benefit and high treatment", "tokenized_content": [2, 25, 17, 7391, 3, 2668, 2007, 25959, 11414, 4905, 2830, 1021, 1930, 3427, 17, 6231, 4798, 7386, 1927, 2149, 17, 3253, 25, 17, 7391, 1930, 9906, 2579, 14258, 12, 8168, 3]}, "items": [{"id": "p_1285", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1286", "content": "leucovorin [SEP] oxantrone and 48-hour continuous infusion of high-dose 5-FU and leucovorin (MFL): low palliative benefit and high treatment-related toxici", "tokenized_content": [2, 9906, 2579, 14258, 3, 28905, 4905, 2830, 1021, 1930, 3427, 17, 6231, 4798, 7386, 1927, 2149, 17, 3253, 25, 17, 7391, 1930, 9906, 2579, 14258, 12, 8168, 1024, 13, 30, 3]}, "items": [{"id": "p_1286", "content": "Leucovorin [SEP] The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists", "score": 1, "type": null, "tokenized_content": [2, 9906, 2579, 14258, 3, 1920, 3500, 9483, 1927, 19731, 2687, 18, 9906, 2579, 14258, 1977, 2251, 22581, 1966, 2496, 5016, 7012, 1966, 1925, 30483, 7229, 1942, 19731, 2687, 10515, 3]}]}
{"query": {"id": "q_1287", "content": "MFL [SEP] d 48-hour continuous infusion of high-dose 5-FU and leucovorin (MFL): low palliative benefit and high treatment-related toxicity.", "tokenized_content": [2, 8168, 1024, 3, 46, 3427, 17, 6231, 4798, 7386, 1927, 2149, 17, 3253, 25, 17, 7391, 1930, 9906, 2579, 14258, 12, 8168, 1024, 13, 30, 2330, 13278, 5580, 1930, 2149, 3]}, "items": [{"id": "p_1287", "content": "MFL combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8168, 1024, 3921, 3, 3]}]}
{"query": {"id": "q_1288", "content": "toxicity [SEP] ovorin (MFL): low palliative benefit and high treatment-related toxicity.", "tokenized_content": [2, 5532, 3, 4285, 14258, 12, 8168, 1024, 13, 30, 2330, 13278, 5580, 1930, 2149, 2311, 17, 2712, 5532, 18, 3]}, "items": [{"id": "p_1288", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1289", "content": "breast cancer [SEP] For previously treated advanced breast cancer, there is no standard second-line therapy. Combination chemothe", "tokenized_content": [2, 3739, 2539, 3, 1958, 3024, 2868, 5570, 3739, 2539, 16, 2276, 1977, 2239, 2970, 2812, 17, 2823, 3181, 18, 3921, 12776, 4116, 3]}, "items": [{"id": "p_1289", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_1290", "content": "mitoxantrone [SEP]  no standard second-line therapy. Combination chemotherapy with mitoxantrone, high-dose 5-fluorouracil (5-FU) and leucovorin (MFL regimen) h", "tokenized_content": [2, 25959, 11414, 4905, 2830, 1021, 3, 2239, 2970, 2812, 17, 2823, 3181, 18, 3921, 5318, 1956, 25959, 11414, 4905, 2830, 1021, 16, 2149, 17, 3253, 25, 17, 21353, 12, 25, 3]}, "items": [{"id": "p_1290", "content": "Mitoxantrone [SEP] An anthracenedione-derived antineoplastic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25959, 11414, 4905, 2830, 1021, 3, 1925, 19657, 20670, 2290, 17, 3595, 29128, 9969, 5899, 18, 3]}]}
{"query": {"id": "q_1291", "content": "5-fluorouracil [SEP]  therapy. Combination chemotherapy with mitoxantrone, high-dose 5-fluorouracil (5-FU) and leucovorin (MFL regimen) had been reported as an eff", "tokenized_content": [2, 25, 17, 21353, 3, 3181, 18, 3921, 5318, 1956, 25959, 11414, 4905, 2830, 1021, 16, 2149, 17, 3253, 25, 17, 21353, 12, 25, 17, 7391, 13, 1930, 9906, 2579, 14258, 3]}, "items": [{"id": "p_1291", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1292", "content": "5-FU [SEP] ation chemotherapy with mitoxantrone, high-dose 5-fluorouracil (5-FU) and leucovorin (MFL regimen) had been reported as an effective", "tokenized_content": [2, 25, 17, 7391, 3, 2019, 2001, 5318, 1956, 25959, 11414, 4905, 2830, 1021, 16, 2149, 17, 3253, 25, 17, 21353, 12, 25, 17, 7391, 13, 1930, 9906, 2579, 14258, 12, 3]}, "items": [{"id": "p_1292", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_1293", "content": "leucovorin [SEP] otherapy with mitoxantrone, high-dose 5-fluorouracil (5-FU) and leucovorin (MFL regimen) had been reported as an effective and well tolera", "tokenized_content": [2, 9906, 2579, 14258, 3, 2303, 18644, 1956, 25959, 11414, 4905, 2830, 1021, 16, 2149, 17, 3253, 25, 17, 21353, 12, 25, 17, 7391, 13, 1930, 9906, 2579, 14258, 12, 8168, 3]}, "items": [{"id": "p_1293", "content": "Leucovorin [SEP] The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists", "score": 1, "type": null, "tokenized_content": [2, 9906, 2579, 14258, 3, 1920, 3500, 9483, 1927, 19731, 2687, 18, 9906, 2579, 14258, 1977, 2251, 22581, 1966, 2496, 5016, 7012, 1966, 1925, 30483, 7229, 1942, 19731, 2687, 10515, 3]}]}
{"query": {"id": "q_1294", "content": "MFL regimen [SEP] h mitoxantrone, high-dose 5-fluorouracil (5-FU) and leucovorin (MFL regimen) had been reported as an effective and well tolerated regimen. ", "tokenized_content": [2, 8168, 1024, 8607, 3, 50, 25959, 11414, 4905, 2830, 1021, 16, 2149, 17, 3253, 25, 17, 21353, 12, 25, 17, 7391, 13, 1930, 9906, 2579, 14258, 12, 8168, 1024, 8607, 3]}, "items": [{"id": "p_1294", "content": "MFL combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8168, 1024, 3921, 3, 3]}]}
{"query": {"id": "q_1295", "content": "anthracycline [SEP] ng metastasis predominant. Seven patients had been treated with anthracycline. Seven patients had previously received radiotherapy and seven ", "tokenized_content": [2, 30021, 3, 4375, 5967, 6136, 18, 5260, 2132, 2430, 2252, 2868, 1956, 30021, 18, 5260, 2132, 2430, 3024, 4004, 8822, 1930, 5260, 3]}, "items": [{"id": "p_1295", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_1296", "content": "toxicities [SEP] lete responder had relapse-free survival up to 17 months. Major toxicities were cardiotoxicity and leukopenia. Eight patients were dead in", "tokenized_content": [2, 15251, 3, 6307, 1021, 21285, 2430, 8834, 17, 3294, 3298, 2353, 1942, 2752, 3221, 18, 3044, 15251, 1985, 30490, 1930, 5104, 12903, 18, 5066, 2132, 1985, 9535, 1922, 3]}, "items": [{"id": "p_1296", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1297", "content": "cardiotoxicity [SEP] ad relapse-free survival up to 17 months. Major toxicities were cardiotoxicity and leukopenia. Eight patients were dead in the last follow-up;", "tokenized_content": [2, 30490, 3, 2041, 8834, 17, 3294, 3298, 2353, 1942, 2752, 3221, 18, 3044, 15251, 1985, 30490, 1930, 5104, 12903, 18, 5066, 2132, 1985, 9535, 1922, 1920, 4691, 2396, 17, 2353, 3]}, "items": [{"id": "p_1297", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_1298", "content": "leukopenia [SEP] vival up to 17 months. Major toxicities were cardiotoxicity and leukopenia. Eight patients were dead in the last follow-up; two of them di", "tokenized_content": [2, 5104, 12903, 3, 3548, 1923, 2353, 1942, 2752, 3221, 18, 3044, 15251, 1985, 30490, 1930, 5104, 12903, 18, 5066, 2132, 1985, 9535, 1922, 1920, 4691, 2396, 17, 2353, 31, 2288, 3]}, "items": [{"id": "p_1298", "content": "Leukopenia [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5104, 12903, 3, 3]}]}
{"query": {"id": "q_1299", "content": "toxicity [SEP] apse-free survival up to 17 months. Major toxicities were cardiotoxicity and leukopenia. Eight patients were dead in the last follow-up;", "tokenized_content": [2, 5532, 3, 16311, 1021, 17, 3294, 3298, 2353, 1942, 2752, 3221, 18, 3044, 15251, 1985, 30490, 1930, 5104, 12903, 18, 5066, 2132, 1985, 9535, 1922, 1920, 4691, 2396, 17, 2353, 3]}, "items": [{"id": "p_1299", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1300", "content": "impaired heart function [SEP] r patients who have been treated by chemotherapy and those with impaired heart function requires careful attention.", "tokenized_content": [2, 5761, 4003, 2347, 3, 60, 2132, 2746, 2162, 2252, 2868, 2007, 5318, 1930, 2690, 1956, 5761, 4003, 2347, 5474, 8279, 4976, 18, 3]}, "items": [{"id": "p_1300", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_1301", "content": "vasopressin [SEP] Upregulation of the expression of vasopressin gene in the paraventricular and supraoptic nuclei of the lithiu", "tokenized_content": [2, 20671, 3, 8346, 1927, 1920, 2294, 1927, 20671, 2359, 1922, 1920, 8202, 24722, 1930, 21038, 22733, 6742, 1927, 1920, 10945, 1033, 1032, 3]}, "items": [{"id": "p_1301", "content": "Vasopressins [SEP] Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balan", "score": 1, "type": null, "tokenized_content": [2, 20671, 1036, 3, 22576, 15766, 10224, 6988, 2007, 1920, 3366, 30338, 7056, 25818, 8362, 1927, 2136, 14976, 12, 3170, 10229, 1956, 3038, 13, 1942, 5741, 3224, 4641, 1928, 3]}]}
{"query": {"id": "q_1302", "content": "lithium [SEP] ressin gene in the paraventricular and supraoptic nuclei of the lithium-induced diabetes insipidus rat.", "tokenized_content": [2, 14330, 3, 1995, 6777, 2359, 1922, 1920, 8202, 24722, 1930, 21038, 22733, 6742, 1927, 1920, 14330, 17, 2719, 4032, 2346, 2049, 22291, 3067, 18, 3]}, "items": [{"id": "p_1302", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_1303", "content": "diabetes insipidus [SEP] he paraventricular and supraoptic nuclei of the lithium-induced diabetes insipidus rat.", "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 2234, 8202, 24722, 1930, 21038, 22733, 6742, 1927, 1920, 14330, 17, 2719, 4032, 2346, 2049, 22291, 3067, 18, 3]}, "items": [{"id": "p_1303", "content": "Diabetes Insipidus [SEP] A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiolog", "score": 1, "type": null, "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 43, 2573, 1988, 1977, 4378, 2007, 6439, 3674, 2636, 16, 11093, 1927, 3103, 6222, 1927, 24268, 6960, 16, 1930, 9122, 4053, 2156, 18, 8096, 2167, 3]}]}
{"query": {"id": "q_1304", "content": "arginine vasopressin [SEP] The expression of arginine vasopressin (AVP) gene in the paraventricular (PVN) and supraoptic nuclei (", "tokenized_content": [2, 9732, 20671, 3, 1920, 2294, 1927, 9732, 20671, 12, 20941, 13, 2359, 1922, 1920, 8202, 24722, 12, 22933, 13, 1930, 21038, 22733, 6742, 12, 3]}, "items": [{"id": "p_1304", "content": "Arginine Vasopressin [SEP] The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfid", "score": 1, "type": null, "tokenized_content": [2, 9732, 20671, 3, 1920, 6136, 2386, 1927, 6492, 22576, 15766, 6365, 18, 2176, 1977, 43, 2447, 24010, 3165, 1925, 9732, 2019, 6181, 28, 1930, 2288, 10993, 1960, 3]}]}
{"query": {"id": "q_1305", "content": "AVP [SEP] The expression of arginine vasopressin (AVP) gene in the paraventricular (PVN) and supraoptic nuclei (SON) ", "tokenized_content": [2, 20941, 3, 1920, 2294, 1927, 9732, 20671, 12, 20941, 13, 2359, 1922, 1920, 8202, 24722, 12, 22933, 13, 1930, 21038, 22733, 6742, 12, 9337, 13, 3]}, "items": [{"id": "p_1305", "content": "Arginine Vasopressin [SEP] The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfid", "score": 1, "type": null, "tokenized_content": [2, 9732, 20671, 3, 1920, 6136, 2386, 1927, 6492, 22576, 15766, 6365, 18, 2176, 1977, 43, 2447, 24010, 3165, 1925, 9732, 2019, 6181, 28, 1930, 2288, 10993, 1960, 3]}]}
{"query": {"id": "q_1306", "content": "lithium [SEP] (PVN) and supraoptic nuclei (SON) was investigated in rats with lithium (Li)-induced polyuria, using in situ hybridization histochemist", "tokenized_content": [2, 14330, 3, 12, 22933, 13, 1930, 21038, 22733, 6742, 12, 9337, 13, 1982, 3845, 1922, 3615, 1956, 14330, 12, 2336, 13, 17, 2719, 4286, 8754, 16, 2193, 1922, 4740, 8335, 3]}, "items": [{"id": "p_1306", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_1307", "content": "Li [SEP]  supraoptic nuclei (SON) was investigated in rats with lithium (Li)-induced polyuria, using in situ hybridization histochemistry a", "tokenized_content": [2, 2336, 3, 21038, 22733, 6742, 12, 9337, 13, 1982, 3845, 1922, 3615, 1956, 14330, 12, 2336, 13, 17, 2719, 4286, 8754, 16, 2193, 1922, 4740, 8335, 2968, 7202, 43, 3]}, "items": [{"id": "p_1307", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_1308", "content": "polyuria [SEP] nuclei (SON) was investigated in rats with lithium (Li)-induced polyuria, using in situ hybridization histochemistry and radioimmunoassa", "tokenized_content": [2, 4286, 8754, 3, 6742, 12, 9337, 13, 1982, 3845, 1922, 3615, 1956, 14330, 12, 2336, 13, 17, 2719, 4286, 8754, 16, 2193, 1922, 4740, 8335, 2968, 7202, 1930, 25087, 26509, 3]}, "items": [{"id": "p_1308", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_1309", "content": "LiCl [SEP] munoassay. The male Wistar rats consuming a diet that contained LiCl (60 mmol/kg) for 4 weeks developed marked polyuria. The Li-trea", "tokenized_content": [2, 27347, 3, 10965, 6952, 5590, 2050, 18, 1920, 4005, 15668, 3615, 12359, 43, 3986, 1988, 5543, 27347, 12, 3276, 6397, 19, 3621, 13, 1958, 24, 3625, 3530, 4961, 4286, 8754, 3]}, "items": [{"id": "p_1309", "content": "Lithium Chloride [SEP] A salt of lithium that has been used experimentally as an immunomodulator.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14330, 9140, 3, 43, 7012, 1927, 14330, 1988, 2258, 2252, 2251, 9568, 1966, 1925, 15345, 13505, 18, 3]}]}
{"query": {"id": "q_1310", "content": "sodium [SEP] volume of hypotonic urine with low ionic concentrations. Plasma sodium concentrations were found to be slightly increased in the Li-tr", "tokenized_content": [2, 5227, 3, 3776, 1927, 29107, 6960, 1956, 2330, 11478, 3295, 18, 3582, 5227, 3295, 1985, 2435, 1942, 1998, 5733, 2502, 1922, 1920, 2336, 17, 2025, 3]}, "items": [{"id": "p_1310", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_1311", "content": "dehydration [SEP] treated rats compared with controls. These results suggest that dehydration and/or the activation of visceral afferent inputs may contribut", "tokenized_content": [2, 16585, 3, 2868, 3615, 2452, 1956, 3562, 18, 2144, 2274, 3220, 1988, 16585, 1930, 19, 2014, 1920, 2936, 1927, 12708, 15604, 10230, 2278, 12199, 3]}, "items": [{"id": "p_1311", "content": "Dehydration [SEP] The condition that results from excessive loss of water from a living organism.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16585, 3, 1920, 2625, 1988, 2274, 2037, 9122, 3257, 1927, 3224, 2037, 43, 5818, 9669, 18, 3]}]}
{"query": {"id": "q_1312", "content": "diabetes insipidus [SEP] of AVP gene expression in the PVN and the SON of the Li-induced diabetes insipidus rat.", "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 1927, 20941, 2359, 2294, 1922, 1920, 22933, 1930, 1920, 9337, 1927, 1920, 2336, 17, 2719, 4032, 2346, 2049, 22291, 3067, 18, 3]}, "items": [{"id": "p_1312", "content": "Diabetes Insipidus [SEP] A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiolog", "score": 1, "type": null, "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 43, 2573, 1988, 1977, 4378, 2007, 6439, 3674, 2636, 16, 11093, 1927, 3103, 6222, 1927, 24268, 6960, 16, 1930, 9122, 4053, 2156, 18, 8096, 2167, 3]}]}
{"query": {"id": "q_1313", "content": "Suxamethonium [SEP] Suxamethonium-induced cardiac arrest and death following 5 days of immobiliza", "tokenized_content": [2, 2020, 11414, 23568, 15414, 3, 2020, 11414, 23568, 15414, 17, 2719, 4435, 8048, 1930, 3539, 2894, 25, 3000, 1927, 26329, 2061, 1019, 3]}, "items": [{"id": "p_1313", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_1314", "content": "cardiac arrest [SEP] Suxamethonium-induced cardiac arrest and death following 5 days of immobilization.", "tokenized_content": [2, 4435, 8048, 3, 2020, 11414, 23568, 15414, 17, 2719, 4435, 8048, 1930, 3539, 2894, 25, 3000, 1927, 16704, 18, 3]}, "items": [{"id": "p_1314", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_1315", "content": "death [SEP] Suxamethonium-induced cardiac arrest and death following 5 days of immobilization.", "tokenized_content": [2, 3539, 3, 2020, 11414, 23568, 15414, 17, 2719, 4435, 8048, 1930, 3539, 2894, 25, 3000, 1927, 16704, 18, 3]}, "items": [{"id": "p_1315", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_1316", "content": "cardiac arrest [SEP] The present report describes a case of cardiac arrest and subsequent death as a result of hyperkalaemia following the", "tokenized_content": [2, 4435, 8048, 3, 1920, 2481, 3809, 9845, 43, 3087, 1927, 4435, 8048, 1930, 4521, 3539, 1966, 43, 3211, 1927, 4194, 7640, 5148, 3847, 2894, 1920, 3]}, "items": [{"id": "p_1316", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_1317", "content": "death [SEP] resent report describes a case of cardiac arrest and subsequent death as a result of hyperkalaemia following the use of suxamethonium", "tokenized_content": [2, 3539, 3, 1995, 1939, 3809, 9845, 43, 3087, 1927, 4435, 8048, 1930, 4521, 3539, 1966, 43, 3211, 1927, 4194, 7640, 5148, 3847, 2894, 1920, 2485, 1927, 2020, 11414, 23568, 15414, 3]}, "items": [{"id": "p_1317", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_1318", "content": "hyperkalaemia [SEP] es a case of cardiac arrest and subsequent death as a result of hyperkalaemia following the use of suxamethonium in a 23-year-old Malawian wo", "tokenized_content": [2, 4194, 7640, 5148, 3847, 3, 2376, 43, 3087, 1927, 4435, 8048, 1930, 4521, 3539, 1966, 43, 3211, 1927, 4194, 7640, 5148, 3847, 2894, 1920, 2485, 1927, 2020, 11414, 23568, 15414, 3]}, "items": [{"id": "p_1318", "content": "Hyperkalemia [SEP] Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinicall", "score": 1, "type": null, "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 20756, 2149, 9057, 3110, 1922, 1920, 2877, 16, 2501, 3868, 2810, 1942, 9785, 4604, 11093, 18, 2176, 1977, 4378, 2535, 1024, 3]}]}
{"query": {"id": "q_1319", "content": "suxamethonium [SEP] sequent death as a result of hyperkalaemia following the use of suxamethonium in a 23-year-old Malawian woman. Five days after the onset of t", "tokenized_content": [2, 2020, 11414, 23568, 15414, 3, 2549, 1939, 3539, 1966, 43, 3211, 1927, 4194, 7640, 5148, 3847, 2894, 1920, 2485, 1927, 2020, 11414, 23568, 15414, 1922, 43, 3020, 17, 2476, 17, 3]}, "items": [{"id": "p_1319", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_1320", "content": "meningitis [SEP] ld Malawian woman. Five days after the onset of the symptoms of meningitis, the patient aspirated stomach contents and needed endotracheal", "tokenized_content": [2, 16780, 3, 5091, 24660, 1928, 10440, 18, 3628, 3000, 2256, 1920, 4727, 1927, 1920, 3601, 1927, 16780, 16, 1920, 2774, 25543, 11399, 8906, 1930, 4500, 26315, 3]}, "items": [{"id": "p_1320", "content": "Meningitis [SEP] Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infect", "score": 1, "type": null, "tokenized_content": [2, 16780, 3, 4531, 1927, 1920, 12275, 1036, 1927, 1920, 3068, 1930, 19, 2014, 6071, 6670, 16, 2154, 3149, 1927, 1920, 4269, 1019, 3126, 31, 15243, 20815, 31, 1930, 25389, 3126, 18, 15119, 3]}]}
{"query": {"id": "q_1321", "content": "bradycardia [SEP] eal intubation. Forty seconds after injection of suxamethonium, bradycardia and cardiac arrest occurred. Attempts to resuscitate the patien", "tokenized_content": [2, 26192, 3, 11377, 1024, 15686, 18, 11270, 9362, 2256, 4107, 1927, 2020, 11414, 23568, 15414, 16, 26192, 1930, 4435, 8048, 4807, 18, 9866, 1942, 14037, 28698, 1920, 2091, 1917, 3]}, "items": [{"id": "p_1321", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_1322", "content": "potassium [SEP] resuscitate the patient were not successful. The serum level of potassium was observed to be 8.4 mequiv L-1. Apart from the reduction in ", "tokenized_content": [2, 9057, 3, 14037, 28698, 1920, 2774, 1985, 2084, 4654, 18, 1920, 3256, 2237, 1927, 9057, 1982, 2528, 1942, 1998, 28, 18, 24, 25509, 15444, 1020, 54, 17, 21, 18, 9615, 3]}, "items": [{"id": "p_1322", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1323", "content": "hypersensitivity [SEP] of suxamethonium. It is postulated that her death was caused by hypersensitivity to suxamethonium, associated with her 5-day immobilization.", "tokenized_content": [2, 14625, 3, 1927, 2020, 11414, 23568, 15414, 18, 2176, 1977, 14024, 1988, 3656, 3539, 1982, 4189, 2007, 14625, 1942, 2020, 11414, 23568, 15414, 16, 2458, 1956, 3656, 25, 17, 3007, 3]}, "items": [{"id": "p_1323", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_1324", "content": "mepivacaine [SEP] An unusual toxic reaction to axillary block by mepivacaine with adrenaline.", "tokenized_content": [2, 17257, 20026, 3, 1925, 12236, 6161, 3227, 1942, 17619, 3367, 2007, 17257, 20026, 1956, 10651, 2053, 18, 3]}, "items": [{"id": "p_1324", "content": "Mepivacaine [SEP] A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for inf", "score": 1, "type": null, "tokenized_content": [2, 17257, 20026, 3, 43, 3076, 16111, 1988, 1977, 13944, 2712, 1942, 25473, 2308, 24645, 2712, 1942, 19567, 18, 2176, 1977, 3391, 1958, 2122, 3]}]}
{"query": {"id": "q_1325", "content": "adrenaline [SEP] An unusual toxic reaction to axillary block by mepivacaine with adrenaline.", "tokenized_content": [2, 10651, 2053, 3, 1925, 12236, 6161, 3227, 1942, 17619, 3367, 2007, 17257, 20026, 1956, 10651, 2053, 18, 3]}, "items": [{"id": "p_1325", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_1326", "content": "increase in blood pressure [SEP] An increase in blood pressure, accompanied by atrial fibrillation, agitation, incomprehensibl", "tokenized_content": [2, 2760, 1922, 2877, 3772, 3, 1925, 2760, 1922, 2877, 3772, 16, 7936, 2007, 9224, 13671, 16, 18389, 16, 15819, 5920, 2099, 2023, 1024, 3]}, "items": [{"id": "p_1326", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1327", "content": "atrial fibrillation [SEP] An increase in blood pressure, accompanied by atrial fibrillation, agitation, incomprehensible shouts and loss of consciousness, ", "tokenized_content": [2, 9224, 13671, 3, 1925, 2760, 1922, 2877, 3772, 16, 7936, 2007, 9224, 13671, 16, 18389, 16, 15819, 5920, 2099, 2563, 8406, 4732, 1930, 3257, 1927, 16897, 16, 3]}, "items": [{"id": "p_1327", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_1328", "content": "agitation [SEP] increase in blood pressure, accompanied by atrial fibrillation, agitation, incomprehensible shouts and loss of consciousness, was observe", "tokenized_content": [2, 18389, 3, 2760, 1922, 2877, 3772, 16, 7936, 2007, 9224, 13671, 16, 18389, 16, 15819, 5920, 2099, 2563, 8406, 4732, 1930, 3257, 1927, 16897, 16, 1982, 7974, 3]}, "items": [{"id": "p_1328", "content": "Psychomotor Agitation [SEP] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug tox", "score": 1, "type": null, "tokenized_content": [2, 26261, 18389, 3, 43, 14452, 1927, 6172, 26481, 2458, 1956, 2502, 4842, 2455, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 7580, 2433, 2838, 3780, 3]}]}
{"query": {"id": "q_1329", "content": "incomprehensible shouts [SEP]  blood pressure, accompanied by atrial fibrillation, agitation, incomprehensible shouts and loss of consciousness, was observed in an elderly, ASA clas", "tokenized_content": [2, 15819, 5920, 2099, 2563, 8406, 4732, 3, 2877, 3772, 16, 7936, 2007, 9224, 13671, 16, 18389, 16, 15819, 5920, 2099, 2563, 8406, 4732, 1930, 3257, 1927, 16897, 16, 1982, 2528, 3]}, "items": [{"id": "p_1329", "content": "Neurobehavioral Manifestations [SEP] Signs and symptoms of higher cortical dysfunction caused by organic conditions. These include certain behavioral alterations and", "score": 1, "type": null, "tokenized_content": [2, 29668, 10952, 3, 6879, 1930, 3601, 1927, 2580, 5586, 5273, 4189, 2007, 6805, 2961, 18, 2144, 3951, 4908, 5343, 5996, 1930, 3]}]}
{"query": {"id": "q_1330", "content": "loss of consciousness [SEP]  by atrial fibrillation, agitation, incomprehensible shouts and loss of consciousness, was observed in an elderly, ASA classification group II, cardi", "tokenized_content": [2, 3257, 1927, 16897, 3, 2007, 9224, 13671, 16, 18389, 16, 15819, 5920, 2099, 2563, 8406, 4732, 1930, 3257, 1927, 16897, 16, 1982, 2528, 1922, 1925, 7354, 16, 15634, 5492, 2210, 3]}, "items": [{"id": "p_1330", "content": "Unconsciousness [SEP] Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental", "score": 1, "type": null, "tokenized_content": [2, 29267, 2971, 3, 3257, 1927, 1920, 3682, 1942, 6698, 8755, 1927, 3543, 1930, 3515, 4252, 1956, 7686, 3028, 10854, 1942, 4813, 3]}]}
{"query": {"id": "q_1331", "content": "mepivacaine [SEP] medicated male, 12 min after performance of axillary block with mepivacaine 850 mg containing adrenaline 0.225 mg, for correction of Dupuyt", "tokenized_content": [2, 17257, 20026, 3, 3935, 1981, 4005, 16, 2369, 2360, 2256, 3604, 1927, 17619, 3367, 1956, 17257, 20026, 23196, 2786, 3165, 10651, 2053, 20, 18, 16056, 2786, 16, 1958, 6820, 1927, 3]}, "items": [{"id": "p_1331", "content": "Mepivacaine [SEP] A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for inf", "score": 1, "type": null, "tokenized_content": [2, 17257, 20026, 3, 43, 3076, 16111, 1988, 1977, 13944, 2712, 1942, 25473, 2308, 24645, 2712, 1942, 19567, 18, 2176, 1977, 3391, 1958, 2122, 3]}]}
{"query": {"id": "q_1332", "content": "adrenaline [SEP] erformance of axillary block with mepivacaine 850 mg containing adrenaline 0.225 mg, for correction of Dupuytren's contracture. After intr", "tokenized_content": [2, 10651, 2053, 3, 2668, 2231, 2152, 1927, 17619, 3367, 1956, 17257, 20026, 23196, 2786, 3165, 10651, 2053, 20, 18, 16056, 2786, 16, 1958, 6820, 1927, 25139, 19364, 4265, 1022, 11, 3]}, "items": [{"id": "p_1332", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_1333", "content": "Dupuytren's contracture [SEP] acaine 850 mg containing adrenaline 0.225 mg, for correction of Dupuytren's contracture. After intravenous administration of labetalol, metoprolol and ", "tokenized_content": [2, 25139, 19364, 4265, 1022, 11, 61, 14456, 2027, 3, 18699, 2053, 23196, 2786, 3165, 10651, 2053, 20, 18, 16056, 2786, 16, 1958, 6820, 1927, 25139, 19364, 4265, 1022, 11, 61, 3]}, "items": [{"id": "p_1333", "content": "Dupuytren Contracture [SEP] A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of t", "score": 1, "type": null, "tokenized_content": [2, 25139, 19364, 4265, 1022, 14456, 2027, 3, 43, 21823, 11299, 1927, 1920, 15516, 1933, 24248, 4378, 2007, 16121, 1930, 14456, 2027, 1927, 1920, 15711, 7581, 1990, 1920, 15516, 1933, 7553, 1927, 62, 3]}]}
{"query": {"id": "q_1334", "content": "labetalol [SEP] of Dupuytren's contracture. After intravenous administration of labetalol, metoprolol and midazolam the patient's condition improved, and", "tokenized_content": [2, 2857, 3949, 1945, 3, 1927, 25139, 19364, 4265, 1022, 11, 61, 14456, 2027, 18, 2256, 7307, 4183, 1927, 2857, 3949, 1945, 16, 2130, 17712, 1945, 1930, 23380, 1920, 2774, 11, 3]}, "items": [{"id": "p_1334", "content": "Labetalol [SEP] A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.\n ", "score": 1, "type": null, "tokenized_content": [2, 2857, 3949, 1945, 3, 43, 20734, 10406, 10533, 1988, 1977, 43, 2447, 17, 21129, 4127, 25419, 2185, 14580, 1927, 4666, 17, 13672, 4086, 1930, 4595, 17, 21, 13672, 4086, 18, 3]}]}
{"query": {"id": "q_1335", "content": "metoprolol [SEP] n's contracture. After intravenous administration of labetalol, metoprolol and midazolam the patient's condition improved, and 15 min late", "tokenized_content": [2, 2130, 17712, 1945, 3, 56, 11, 61, 14456, 2027, 18, 2256, 7307, 4183, 1927, 2857, 3949, 1945, 16, 2130, 17712, 1945, 1930, 23380, 1920, 2774, 11, 61, 2625, 4305, 16, 3]}, "items": [{"id": "p_1335", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_1336", "content": "midazolam [SEP] . After intravenous administration of labetalol, metoprolol and midazolam the patient's condition improved, and 15 min later he woke up. ", "tokenized_content": [2, 23380, 3, 18, 2256, 7307, 4183, 1927, 2857, 3949, 1945, 16, 2130, 17712, 1945, 1930, 23380, 1920, 2774, 11, 61, 2625, 4305, 16, 1930, 2461, 2360, 3690, 2234, 26334, 3324, 3]}, "items": [{"id": "p_1336", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_1337", "content": "tacrolimus [SEP] nd histopathologic examination of renal allografts treated with tacrolimus (FK506) for at least one year.", "tokenized_content": [2, 21801, 3, 8026, 20324, 4981, 1927, 4604, 24652, 2868, 1956, 21801, 12, 30269, 13, 1958, 2019, 3464, 2340, 2476, 18, 3]}, "items": [{"id": "p_1337", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1338", "content": "FK506 [SEP] ologic examination of renal allografts treated with tacrolimus (FK506) for at least one year.", "tokenized_content": [2, 30269, 3, 2865, 2021, 1935, 4981, 1927, 4604, 24652, 2868, 1956, 21801, 12, 30269, 13, 1958, 2019, 3464, 2340, 2476, 18, 3]}, "items": [{"id": "p_1338", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1339", "content": "tacrolimus [SEP] enal allografts from 1 9 renal transplant patients treated with tacrolimus (FK506) for more than 1 year. METHODS: Twenty-six renal allogra", "tokenized_content": [2, 21801, 3, 2066, 1923, 24652, 2037, 21, 29, 4604, 5192, 2132, 2868, 1956, 21801, 12, 30269, 13, 1958, 2253, 2254, 21, 2476, 18, 2860, 30, 7639, 17, 3798, 4604, 13407, 3]}, "items": [{"id": "p_1339", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1340", "content": "FK506 [SEP] fts from 1 9 renal transplant patients treated with tacrolimus (FK506) for more than 1 year. METHODS: Twenty-six renal allograft biop", "tokenized_content": [2, 30269, 3, 17022, 2037, 21, 29, 4604, 5192, 2132, 2868, 1956, 21801, 12, 30269, 13, 1958, 2253, 2254, 21, 2476, 18, 2860, 30, 7639, 17, 3798, 4604, 15941, 20864, 3]}, "items": [{"id": "p_1340", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_1341", "content": "IgA nephropathy [SEP] R; n = 4), chronic rejection (CR; n=5), AR+CR (n =4), recurrent IgA nephropathy (n =5), normal findings (n =2), minimal-type chronic FK506 neph", "tokenized_content": [2, 12114, 15582, 3, 60, 31, 56, 33, 24, 13, 16, 3724, 10820, 12, 2345, 31, 56, 33, 25, 13, 16, 2245, 15, 2345, 12, 56, 33, 24, 13, 16, 7457, 3]}, "items": [{"id": "p_1341", "content": "Glomerulonephritis, IGA [SEP] A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERUL", "score": 1, "type": null, "tokenized_content": [2, 27057, 16, 12114, 3, 43, 3724, 2386, 1927, 27057, 4378, 2007, 14371, 1927, 7700, 11837, 43, 1922, 1920, 24310, 3403, 12, 19268, 3]}]}
{"query": {"id": "q_1342", "content": "nephropathy [SEP]  = 4), chronic rejection (CR; n=5), AR+CR (n =4), recurrent IgA nephropathy (n =5), normal findings (n =2), minimal-type chronic FK506 neph", "tokenized_content": [2, 15582, 3, 33, 24, 13, 16, 3724, 10820, 12, 2345, 31, 56, 33, 25, 13, 16, 2245, 15, 2345, 12, 56, 33, 24, 13, 16, 7457, 12114, 15582, 12, 56, 3]}, "items": [{"id": "p_1342", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1343", "content": "focal segmental glomerulosclerosis [SEP] opathy (angiodegeneration of the arteriolar wall; 20 biopsies), focal segmental glomerulosclerosis (4 biopsies) and the striped form of interstitial fibrosis (11 ", "tokenized_content": [2, 8083, 16294, 19268, 25081, 3, 20349, 28935, 12, 29220, 3695, 14687, 5524, 1929, 1927, 1920, 12480, 4362, 4821, 31, 2036, 9782, 13, 16, 8083, 16294, 19268, 25081, 12, 24, 9782, 3]}, "items": [{"id": "p_1343", "content": "Glomerulosclerosis, Focal Segmental [SEP] A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary", "score": 1, "type": null, "tokenized_content": [2, 19268, 25081, 16, 8083, 16294, 3, 43, 17828, 4741, 2014, 4785, 2576, 1958, 43, 2601, 1927, 11655, 4047, 1988, 2258, 3137, 5092, 16, 3065, 2014, 4067, 3]}]}
{"query": {"id": "q_1344", "content": "interstitial fibrosis [SEP] gmental glomerulosclerosis (4 biopsies) and the striped form of interstitial fibrosis (11 biopsies). The serum creatinine levels of patients in the m", "tokenized_content": [2, 11584, 6769, 3, 5711, 2795, 19268, 25081, 12, 24, 9782, 13, 1930, 1920, 29809, 1007, 2386, 1927, 11584, 6769, 12, 2513, 9782, 13, 18, 1920, 3256, 9374, 2428, 1927, 2132, 3]}, "items": [{"id": "p_1344", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_1345", "content": "creatinine [SEP]  striped form of interstitial fibrosis (11 biopsies). The serum creatinine levels of patients in the mild-type chronic FK506 nephropathy g", "tokenized_content": [2, 9374, 3, 29809, 1007, 2386, 1927, 11584, 6769, 12, 2513, 9782, 13, 18, 1920, 3256, 9374, 2428, 1927, 2132, 1922, 1920, 5809, 17, 2601, 3724, 30269, 15582, 49, 3]}, "items": [{"id": "p_1345", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_1346", "content": "acetylcholine [SEP]  stimulation of endogenous nerve growth factor synthesis by the acetylcholine releaser PG-9.", "tokenized_content": [2, 14561, 3, 4177, 1927, 5355, 5507, 2905, 2991, 4271, 2007, 1920, 14561, 4012, 1005, 5306, 17, 29, 18, 3]}, "items": [{"id": "p_1346", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_1347", "content": "PG-9 [SEP] ous nerve growth factor synthesis by the acetylcholine releaser PG-9.", "tokenized_content": [2, 5306, 17, 29, 3, 17208, 1036, 5507, 2905, 2991, 4271, 2007, 1920, 14561, 4012, 1005, 5306, 17, 29, 18, 3]}, "items": [{"id": "p_1347", "content": "N-methyltropan-3-yl 2-(4-bromophenyl)propionate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 1997, 8228, 1022, 17, 23, 17, 12111, 22, 17, 12, 24, 17, 21392, 17616, 2199, 13, 24682, 3, 3]}]}
{"query": {"id": "q_1348", "content": "PG-9 [SEP] The effects of PG-9 (3alpha-tropyl 2-(p-bromophenyl)propionate), the acetylcholine ", "tokenized_content": [2, 5306, 17, 29, 3, 1920, 2564, 1927, 5306, 17, 29, 12, 5694, 13857, 2722, 17, 8465, 2199, 22, 17, 12, 58, 17, 21392, 17616, 2199, 13, 24682, 13, 16, 1920, 3]}, "items": [{"id": "p_1348", "content": "N-methyltropan-3-yl 2-(4-bromophenyl)propionate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 1997, 8228, 1022, 17, 23, 17, 12111, 22, 17, 12, 24, 17, 21392, 17616, 2199, 13, 24682, 3, 3]}]}
{"query": {"id": "q_1349", "content": "3alpha-tropyl 2-(p-bromophenyl)propionate [SEP] The effects of PG-9 (3alpha-tropyl 2-(p-bromophenyl)propionate), the acetylcholine releaser, on memory processes and nerve gro", "tokenized_content": [2, 5694, 13857, 2722, 17, 8465, 2199, 22, 17, 12, 58, 17, 21392, 17616, 2199, 13, 24682, 3, 1920, 2564, 1927, 5306, 17, 29, 12, 5694, 13857, 2722, 17, 8465, 2199, 3]}, "items": [{"id": "p_1349", "content": "N-methyltropan-3-yl 2-(4-bromophenyl)propionate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 1997, 8228, 1022, 17, 23, 17, 12111, 22, 17, 12, 24, 17, 21392, 17616, 2199, 13, 24682, 3, 3]}]}
{"query": {"id": "q_1350", "content": "acetylcholine [SEP] ffects of PG-9 (3alpha-tropyl 2-(p-bromophenyl)propionate), the acetylcholine releaser, on memory processes and nerve growth factor (NGF) syn", "tokenized_content": [2, 14561, 3, 10735, 2284, 1927, 5306, 17, 29, 12, 5694, 13857, 2722, 17, 8465, 2199, 22, 17, 12, 58, 17, 21392, 17616, 2199, 13, 24682, 13, 16, 1920, 14561, 4012, 3]}, "items": [{"id": "p_1350", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_1351", "content": "amnesia [SEP] p.), administered 20 min before the training session, prevented amnesia induced by both the non selective antimuscarinic drug scopolami", "tokenized_content": [2, 14701, 7156, 3, 58, 18, 13, 16, 5254, 2036, 2360, 3119, 1920, 4096, 7355, 16, 8715, 14701, 7156, 2719, 2007, 2321, 1920, 2447, 5328, 20330, 7801, 18979, 2838, 25392, 10173, 3]}, "items": [{"id": "p_1351", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_1352", "content": "scopolamine [SEP] d amnesia induced by both the non selective antimuscarinic drug scopolamine and the M1-selective antagonist S-(-)-ET-126. In the same exper", "tokenized_content": [2, 25392, 10173, 25157, 3, 46, 14701, 7156, 2719, 2007, 2321, 1920, 2447, 5328, 20330, 7801, 18979, 2838, 25392, 10173, 25157, 1930, 1920, 8510, 17, 5328, 8151, 61, 17, 12, 17, 3]}, "items": [{"id": "p_1352", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_1353", "content": "S-(-)-ET-126 [SEP] antimuscarinic drug scopolamine and the M1-selective antagonist S-(-)-ET-126. In the same experimental conditions, PG-9 (5-20 microg per mou", "tokenized_content": [2, 61, 17, 12, 17, 13, 17, 2140, 17, 10483, 3, 20330, 7801, 18979, 2838, 25392, 10173, 25157, 1930, 1920, 8510, 17, 5328, 8151, 61, 17, 12, 17, 13, 17, 2140, 3]}, "items": [{"id": "p_1353", "content": "ET 126 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2140, 10483, 3, 3]}]}
{"query": {"id": "q_1354", "content": "Angioedema [SEP] Angioedema due to ACE inhibitors: common and inadequately diagnosed.", "tokenized_content": [2, 29220, 16670, 3, 29220, 16670, 2810, 1942, 8298, 4472, 30, 3059, 1930, 11391, 1954, 5377, 18, 3]}, "items": [{"id": "p_1354", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_1355", "content": "ACE inhibitors [SEP] Angioedema due to ACE inhibitors: common and inadequately diagnosed.", "tokenized_content": [2, 8298, 4472, 3, 29220, 16670, 2810, 1942, 8298, 4472, 30, 3059, 1930, 11391, 1954, 5377, 18, 3]}, "items": [{"id": "p_1355", "content": "Angiotensin-Converting Enzyme Inhibitors [SEP] A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect", "score": 1, "type": null, "tokenized_content": [2, 10814, 17, 15025, 4113, 4472, 3, 43, 2921, 1927, 4195, 6098, 2730, 11615, 2032, 1920, 2311, 1927, 5579, 1930, 4003, 4574, 18, 2611, 10788, 2310, 12173, 2495, 3]}]}
{"query": {"id": "q_1356", "content": "angioedema [SEP] The estimated incidence of angioedema during angiotensin-converting enzyme (ACE) inhibitor treatment ", "tokenized_content": [2, 29220, 16670, 3, 1920, 4185, 4332, 1927, 29220, 16670, 2409, 10814, 17, 15025, 4113, 12, 8298, 13, 4106, 2311, 3]}, "items": [{"id": "p_1356", "content": "Angioedema [SEP] Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs i", "score": 1, "type": null, "tokenized_content": [2, 29220, 16670, 3, 11438, 5884, 1920, 6515, 20201, 16, 8634, 16, 2014, 24298, 3878, 16, 7479, 6579, 10144, 18, 29220, 16670, 3868, 5110, 51, 3]}]}
{"query": {"id": "q_1357", "content": "angiotensin-converting enzyme (ACE) inhibitor [SEP] The estimated incidence of angioedema during angiotensin-converting enzyme (ACE) inhibitor treatment is between 1 and 7 per thousand patients. This potent", "tokenized_content": [2, 10814, 17, 15025, 4113, 12, 8298, 13, 4106, 3, 1920, 4185, 4332, 1927, 29220, 16670, 2409, 10814, 17, 15025, 4113, 12, 8298, 13, 4106, 2311, 1977, 2192, 21, 1930, 27, 3]}, "items": [{"id": "p_1357", "content": "Angiotensin-Converting Enzyme Inhibitors [SEP] A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect", "score": 1, "type": null, "tokenized_content": [2, 10814, 17, 15025, 4113, 4472, 3, 43, 2921, 1927, 4195, 6098, 2730, 11615, 2032, 1920, 2311, 1927, 5579, 1930, 4003, 4574, 18, 2611, 10788, 2310, 12173, 2495, 3]}]}
{"query": {"id": "q_1358", "content": "atracurium [SEP] ecurarization in the recovery room is reported. Accumulation of atracurium in the intravenous line led to recurarization after flushing th", "tokenized_content": [2, 20319, 18021, 3027, 1989, 3, 3270, 9280, 3027, 7659, 1922, 1920, 5241, 4921, 1977, 2568, 18, 4858, 1927, 20319, 18021, 3027, 1989, 1922, 1920, 7307, 2823, 4866, 1942, 2090, 9280, 3]}, "items": [{"id": "p_1358", "content": "Atracurium [SEP] A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects an", "score": 1, "type": null, "tokenized_content": [2, 20319, 18021, 3027, 1989, 3, 43, 2447, 17, 24999, 15829, 7472, 5899, 1956, 3662, 4392, 1927, 4615, 18, 2496, 3630, 1927, 2228, 5321, 2564, 1925, 3]}]}
{"query": {"id": "q_1359", "content": "respiratory arrest [SEP]  recurarization after flushing the line in the recovery room. A respiratory arrest with severe desaturation and bradycardia occurred. Circumstance", "tokenized_content": [2, 5481, 8048, 3, 2090, 9280, 3027, 7659, 2256, 2848, 6150, 1941, 1920, 2823, 1922, 1920, 5241, 4921, 18, 43, 5481, 8048, 1956, 4010, 30078, 1943, 1930, 26192, 4807, 18, 11609, 3]}, "items": [{"id": "p_1359", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_1360", "content": "desaturation [SEP] the line in the recovery room. A respiratory arrest with severe desaturation and bradycardia occurred. Circumstances leading to this event a", "tokenized_content": [2, 30078, 1943, 3, 1920, 2823, 1922, 1920, 5241, 4921, 18, 43, 5481, 8048, 1956, 4010, 30078, 1943, 1930, 26192, 4807, 18, 12294, 4523, 1942, 2052, 4817, 43, 3]}, "items": [{"id": "p_1360", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_1361", "content": "bradycardia [SEP] ecovery room. A respiratory arrest with severe desaturation and bradycardia occurred. Circumstances leading to this event and the mechanism", "tokenized_content": [2, 26192, 3, 25590, 2004, 1012, 4921, 18, 43, 5481, 8048, 1956, 4010, 30078, 1943, 1930, 26192, 4807, 18, 12294, 4523, 1942, 2052, 4817, 1930, 1920, 2856, 3]}, "items": [{"id": "p_1361", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_1362", "content": "neuromuscular blockade [SEP] rcumstances leading to this event and the mechanisms enabling a neuromuscular blockade to occur, following the administration of a small dose of relax", "tokenized_content": [2, 15829, 9847, 3, 7399, 22627, 3285, 3707, 4523, 1942, 2052, 4817, 1930, 1920, 3531, 12180, 43, 15829, 9847, 1942, 4704, 16, 2894, 1920, 4183, 1927, 43, 2858, 3253, 1927, 7327, 3]}, "items": [{"id": "p_1362", "content": "Neuromuscular Manifestations [SEP] Signs and symptoms associated with diseases of the muscle, neuromuscular junction, or peripheral nerves.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15829, 10952, 3, 6879, 1930, 3601, 2458, 1956, 3902, 1927, 1920, 3760, 16, 15829, 6910, 16, 2014, 5009, 12014, 18, 3]}]}
{"query": {"id": "q_1363", "content": "oral contraceptives [SEP] Recurrent use of newer oral contraceptives and the risk of venous thromboembolism.", "tokenized_content": [2, 4726, 25434, 3, 7457, 2485, 1927, 18012, 4726, 25434, 1930, 1920, 2565, 1927, 8562, 23821, 18, 3]}, "items": [{"id": "p_1363", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_1364", "content": "venous thromboembolism [SEP] Recurrent use of newer oral contraceptives and the risk of venous thromboembolism.", "tokenized_content": [2, 8562, 23821, 3, 7457, 2485, 1927, 18012, 4726, 25434, 1930, 1920, 2565, 1927, 8562, 23821, 18, 3]}, "items": [{"id": "p_1364", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1365", "content": "venous thromboembolism [SEP] The epidemiological studies that assessed the risk of venous thromboembolism (VTE) associated with newer oral contraceptives (OC) did not di", "tokenized_content": [2, 8562, 23821, 3, 1920, 9591, 2351, 1988, 3683, 1920, 2565, 1927, 8562, 23821, 12, 16931, 13, 2458, 1956, 18012, 4726, 25434, 12, 5084, 13, 2811, 2084, 2137, 3]}, "items": [{"id": "p_1365", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1366", "content": "VTE [SEP] gical studies that assessed the risk of venous thromboembolism (VTE) associated with newer oral contraceptives (OC) did not disting", "tokenized_content": [2, 16931, 3, 7217, 5657, 2351, 1988, 3683, 1920, 2565, 1927, 8562, 23821, 12, 16931, 13, 2458, 1956, 18012, 4726, 25434, 12, 5084, 13, 2811, 2084, 4190, 1029, 3]}, "items": [{"id": "p_1366", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1367", "content": "oral contraceptives [SEP]  the risk of venous thromboembolism (VTE) associated with newer oral contraceptives (OC) did not distinguish between patterns of OC use, namely fir", "tokenized_content": [2, 4726, 25434, 3, 1920, 2565, 1927, 8562, 23821, 12, 16931, 13, 2458, 1956, 18012, 4726, 25434, 12, 5084, 13, 2811, 2084, 7279, 2192, 4147, 1927, 5084, 2485, 16, 8129, 2527, 3]}, "items": [{"id": "p_1367", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_1368", "content": "OC [SEP] hromboembolism (VTE) associated with newer oral contraceptives (OC) did not distinguish between patterns of OC use, namely first-t", "tokenized_content": [2, 5084, 3, 3668, 10123, 6802, 17010, 22616, 12, 16931, 13, 2458, 1956, 18012, 4726, 25434, 12, 5084, 13, 2811, 2084, 7279, 2192, 4147, 1927, 5084, 2485, 16, 8129, 2561, 17, 3]}, "items": [{"id": "p_1368", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_1369", "content": "apomorphine [SEP] Development of apomorphine-induced aggressive behavior: comparison of adult male and femal", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 2740, 1927, 11466, 12492, 11119, 7969, 2912, 17, 2719, 8704, 3379, 30, 3723, 1927, 4160, 4005, 1930, 3210, 1923, 3]}, "items": [{"id": "p_1369", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_1370", "content": "aggressive behavior [SEP] Development of apomorphine-induced aggressive behavior: comparison of adult male and female Wistar rats.", "tokenized_content": [2, 8704, 3379, 3, 2740, 1927, 11466, 12492, 11119, 7969, 2912, 17, 2719, 8704, 3379, 30, 3723, 1927, 4160, 4005, 1930, 4232, 15668, 3615, 18, 3]}, "items": [{"id": "p_1370", "content": "Personality Disorders [SEP] A major deviation from normal patterns of behavior.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10111, 4414, 3, 43, 3044, 6015, 2037, 2791, 4147, 1927, 3379, 18, 3]}]}
{"query": {"id": "q_1371", "content": "apomorphine [SEP] The development of apomorphine-induced (1.0 mg/kg s.c. once daily) aggressive behavior of adul", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 1920, 2740, 1927, 11466, 12492, 11119, 7969, 2912, 17, 2719, 12, 21, 18, 20, 2786, 19, 3621, 61, 18, 45, 18, 5361, 4692, 13, 3]}, "items": [{"id": "p_1371", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_1372", "content": "aggressive behavior [SEP]  development of apomorphine-induced (1.0 mg/kg s.c. once daily) aggressive behavior of adult male and female Wistar rats obtained from the same bre", "tokenized_content": [2, 8704, 3379, 3, 2740, 1927, 11466, 12492, 11119, 7969, 2912, 17, 2719, 12, 21, 18, 20, 2786, 19, 3621, 61, 18, 45, 18, 5361, 4692, 13, 8704, 3379, 1927, 4160, 3]}, "items": [{"id": "p_1372", "content": "Personality Disorders [SEP] A major deviation from normal patterns of behavior.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10111, 4414, 3, 43, 3044, 6015, 2037, 2791, 4147, 1927, 3379, 18, 3]}]}
{"query": {"id": "q_1373", "content": "aggressiveness [SEP]  aggressive behavior as evidenced by the increased intensity of aggressiveness and shortened latency before the first attack toward the oppone", "tokenized_content": [2, 23161, 3, 8704, 3379, 1966, 11400, 2007, 1920, 2502, 4266, 1927, 23161, 1930, 17112, 9393, 3119, 1920, 2561, 8926, 4205, 1920, 2494, 21851, 1021, 3]}, "items": [{"id": "p_1373", "content": "Personality Disorders [SEP] A major deviation from normal patterns of behavior.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10111, 4414, 3, 43, 3044, 6015, 2037, 2791, 4147, 1927, 3379, 18, 3]}]}
{"query": {"id": "q_1374", "content": "Serotonergic antidepressants [SEP] Serotonergic antidepressants and urinary incontinence.", "tokenized_content": [2, 21292, 17722, 3, 21292, 17722, 1930, 7075, 16783, 18, 3]}, "items": [{"id": "p_1374", "content": "Serotonin Agents [SEP] Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of s", "score": 1, "type": null, "tokenized_content": [2, 11153, 4820, 3, 4195, 2251, 1958, 2310, 2564, 1990, 21292, 3771, 18, 2706, 2144, 2032, 4195, 1988, 4081, 11153, 4086, 16, 1920, 3308, 4048, 1927, 61, 3]}]}
{"query": {"id": "q_1375", "content": "urinary incontinence [SEP] Serotonergic antidepressants and urinary incontinence.", "tokenized_content": [2, 7075, 16783, 3, 21292, 17722, 1930, 7075, 16783, 18, 3]}, "items": [{"id": "p_1375", "content": "Urinary Incontinence [SEP] Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types o", "score": 1, "type": null, "tokenized_content": [2, 7075, 16783, 3, 28493, 3257, 1927, 6960, 16, 2427, 1966, 9186, 1941, 1927, 6960, 18, 2176, 1977, 43, 3226, 1927, 3425, 5030, 6598, 4028, 18, 3044, 3584, 57, 3]}]}
{"query": {"id": "q_1376", "content": "serotonergic antidepressants [SEP] Many new serotonergic antidepressants have been introduced over the past decade. Although urinary inc", "tokenized_content": [2, 21292, 17722, 3, 3086, 2814, 21292, 17722, 2162, 2252, 6373, 2338, 1920, 5375, 10468, 18, 2876, 7075, 2043, 3]}, "items": [{"id": "p_1376", "content": "Serotonin Agents [SEP] Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of s", "score": 1, "type": null, "tokenized_content": [2, 11153, 4820, 3, 4195, 2251, 1958, 2310, 2564, 1990, 21292, 3771, 18, 2706, 2144, 2032, 4195, 1988, 4081, 11153, 4086, 16, 1920, 3308, 4048, 1927, 61, 3]}]}
{"query": {"id": "q_1377", "content": "urinary incontinence [SEP] depressants have been introduced over the past decade. Although urinary incontinence is listed as one side effect of these drugs in their package in", "tokenized_content": [2, 7075, 16783, 3, 20852, 2356, 2162, 2252, 6373, 2338, 1920, 5375, 10468, 18, 2876, 7075, 16783, 1977, 7663, 1966, 2340, 4159, 2495, 1927, 2144, 4195, 1922, 2310, 8511, 1922, 3]}, "items": [{"id": "p_1377", "content": "Urinary Incontinence [SEP] Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types o", "score": 1, "type": null, "tokenized_content": [2, 7075, 16783, 3, 28493, 3257, 1927, 6960, 16, 2427, 1966, 9186, 1941, 1927, 6960, 18, 2176, 1977, 43, 3226, 1927, 3425, 5030, 6598, 4028, 18, 3044, 3584, 57, 3]}]}
{"query": {"id": "q_1378", "content": "incontinence [SEP] nts have been introduced over the past decade. Although urinary incontinence is listed as one side effect of these drugs in their package in", "tokenized_content": [2, 16783, 3, 17969, 2162, 2252, 6373, 2338, 1920, 5375, 10468, 18, 2876, 7075, 16783, 1977, 7663, 1966, 2340, 4159, 2495, 1927, 2144, 4195, 1922, 2310, 8511, 1922, 3]}, "items": [{"id": "p_1378", "content": "Urinary Incontinence [SEP] Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types o", "score": 1, "type": null, "tokenized_content": [2, 7075, 16783, 3, 28493, 3257, 1927, 6960, 16, 2427, 1966, 9186, 1941, 1927, 6960, 18, 2176, 1977, 43, 3226, 1927, 3425, 5030, 6598, 4028, 18, 3044, 3584, 57, 3]}]}
{"query": {"id": "q_1379", "content": "venlafaxine [SEP] cerns 2 male patients who experienced incontinence while taking venlafaxine. In the present paper the authors describe 2 female patients wh", "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 6580, 3355, 22, 4005, 2132, 2746, 6090, 16783, 2679, 6303, 8102, 5148, 6016, 25204, 18, 1922, 1920, 2481, 4648, 1920, 3875, 5993, 22, 4232, 2132, 3]}, "items": [{"id": "p_1379", "content": "venlafaxine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 3]}]}
{"query": {"id": "q_1380", "content": "serotonin [SEP]  patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a thi", "tokenized_content": [2, 11153, 3, 2132, 2746, 3530, 16783, 4067, 1942, 1920, 5328, 11153, 22957, 4472, 21412, 15387, 1930, 17498, 7317, 2053, 16, 1966, 2486, 1966, 43, 7566, 3]}, "items": [{"id": "p_1380", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_1381", "content": "paroxetine [SEP] inence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effe", "tokenized_content": [2, 21412, 15387, 3, 11116, 15895, 1021, 4067, 1942, 1920, 5328, 11153, 22957, 4472, 21412, 15387, 1930, 17498, 7317, 2053, 16, 1966, 2486, 1966, 43, 4563, 2746, 3530, 2052, 4159, 2121, 3]}, "items": [{"id": "p_1381", "content": "Paroxetine [SEP] A serotonin uptake inhibitor that is effective in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21412, 15387, 3, 43, 11153, 5047, 4106, 1988, 1977, 3655, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_1382", "content": "sertraline [SEP] y to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxi", "tokenized_content": [2, 17498, 7317, 2053, 3, 67, 1942, 1920, 5328, 11153, 22957, 4472, 21412, 15387, 1930, 17498, 7317, 2053, 16, 1966, 2486, 1966, 43, 4563, 2746, 3530, 2052, 4159, 2495, 1990, 8102, 3]}, "items": [{"id": "p_1382", "content": "Sertraline [SEP] A selective serotonin uptake inhibitor that is used in the treatment of depression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17498, 7317, 2053, 3, 43, 5328, 11153, 5047, 4106, 1988, 1977, 2251, 1922, 1920, 2311, 1927, 4621, 18, 3]}]}
{"query": {"id": "q_1383", "content": "lithium carbonate [SEP]  venlafaxine. In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the ", "tokenized_content": [2, 14330, 17724, 3, 8102, 5148, 6016, 25204, 18, 1922, 22, 1927, 1920, 23, 2919, 1920, 2132, 1985, 2222, 6303, 14330, 17724, 1930, 4666, 17, 13628, 16, 2321, 1927, 2154, 2578, 3]}, "items": [{"id": "p_1383", "content": "Lithium Carbonate [SEP] A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL ", "score": 1, "type": null, "tokenized_content": [2, 14330, 17724, 3, 43, 14330, 7012, 16, 5947, 1966, 43, 9494, 17, 14384, 5899, 18, 14330, 4755, 13714, 1920, 4714, 1927, 24241, 19730, 25368, 1036, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_1384", "content": "Hypotension [SEP] Hypotension following the initiation of tizanidine in a patient treated wit", "tokenized_content": [2, 16453, 3, 16453, 2894, 1920, 6035, 1927, 8685, 12813, 8635, 27099, 1922, 43, 2774, 2868, 16086, 3]}, "items": [{"id": "p_1384", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1385", "content": "tizanidine [SEP] Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhi", "tokenized_content": [2, 8685, 12813, 8635, 27099, 3, 16453, 2894, 1920, 6035, 1927, 8685, 12813, 8635, 27099, 1922, 43, 2774, 2868, 1956, 1925, 10814, 15025, 4113, 11035, 1033, 3]}, "items": [{"id": "p_1385", "content": "tizanidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8685, 12813, 8635, 27099, 3, 3]}]}
{"query": {"id": "q_1386", "content": "angiotensin [SEP] owing the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension.", "tokenized_content": [2, 10814, 3, 10762, 1920, 6035, 1927, 8685, 12813, 8635, 27099, 1922, 43, 2774, 2868, 1956, 1925, 10814, 15025, 4113, 4106, 1958, 3724, 5579, 18, 3]}, "items": [{"id": "p_1386", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_1387", "content": "hypertension [SEP] ted with an angiotensin converting enzyme inhibitor for chronic hypertension.", "tokenized_content": [2, 5579, 3, 26080, 1956, 1925, 10814, 15025, 4113, 4106, 1958, 3724, 5579, 18, 3]}, "items": [{"id": "p_1387", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1388", "content": "spasticity [SEP] re one of several pharmacologic agents used in the treatment of spasticity related to disorders of the central nervous system. In addition", "tokenized_content": [2, 29232, 3, 1964, 2340, 1927, 2980, 17225, 4820, 2251, 1922, 1920, 2311, 1927, 29232, 2712, 1942, 4414, 1927, 1920, 4101, 7580, 2433, 18, 1922, 2459, 3]}, "items": [{"id": "p_1388", "content": "Muscle Spasticity [SEP] A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle result", "score": 1, "type": null, "tokenized_content": [2, 3760, 29232, 3, 43, 2386, 1927, 3760, 4506, 6114, 2458, 1956, 5199, 4842, 7428, 2573, 18, 3554, 1942, 9832, 9064, 1927, 43, 21817, 3760, 3211, 3]}]}
{"query": {"id": "q_1389", "content": "disorders of the central nervous system [SEP] macologic agents used in the treatment of spasticity related to disorders of the central nervous system. In addition to their effects on spasticity, certain adverse ca", "tokenized_content": [2, 4414, 1927, 1920, 4101, 7580, 2433, 3, 3433, 4467, 4820, 2251, 1922, 1920, 2311, 1927, 29232, 2712, 1942, 4414, 1927, 1920, 4101, 7580, 2433, 18, 1922, 2459, 1942, 2310, 2564, 3]}, "items": [{"id": "p_1389", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_1390", "content": "angiotensin [SEP] ory effects have been reported. Adults chronically treated with angiotensin converting enzyme inhibitors may have a limited ability to resp", "tokenized_content": [2, 10814, 3, 2014, 1012, 2564, 2162, 2252, 2568, 18, 4440, 16132, 2868, 1956, 10814, 15025, 4113, 4472, 2278, 2162, 43, 3892, 3682, 1942, 2163, 3]}, "items": [{"id": "p_1390", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_1391", "content": "hypotension [SEP] ting enzyme inhibitors may have a limited ability to respond to hypotension when the sympathetic response is simultaneously blocked. The au", "tokenized_content": [2, 16453, 3, 12347, 1029, 4113, 4472, 2278, 2162, 43, 3892, 3682, 1942, 4409, 1942, 16453, 2469, 1920, 11739, 2644, 1977, 7159, 6923, 18, 1920, 5759, 3]}, "items": [{"id": "p_1391", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1392", "content": "lisinopril [SEP]  The authors present a 10-year-old boy chronically treated with lisinopril, an angiotensin converting enzyme inhibitor, to control hyperte", "tokenized_content": [2, 19620, 3522, 2047, 1970, 3, 1920, 3875, 2481, 43, 2119, 17, 2476, 17, 4156, 17914, 16132, 2868, 1956, 19620, 3522, 2047, 1970, 16, 1925, 10814, 15025, 4113, 4106, 16, 1942, 3]}, "items": [{"id": "p_1392", "content": "Lisinopril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hype", "score": 1, "type": null, "tokenized_content": [2, 19620, 3522, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 12, 8298, 4472, 13, 16, 12950, 3500, 16, 1988, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 2483, 1021, 3]}]}
{"query": {"id": "q_1393", "content": "hypertension [SEP] inopril, an angiotensin converting enzyme inhibitor, to control hypertension who developed hypotension following the addition of tizanidine,", "tokenized_content": [2, 5579, 3, 26848, 2047, 1970, 16, 1925, 10814, 15025, 4113, 4106, 16, 1942, 2285, 5579, 2746, 3530, 16453, 2894, 1920, 2459, 1927, 8685, 12813, 8635, 27099, 16, 3]}, "items": [{"id": "p_1393", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1394", "content": "tizanidine [SEP] ypertension who developed hypotension following the addition of tizanidine, an alpha-2 agonist, for the treatment of spasticity. The possi", "tokenized_content": [2, 8685, 12813, 8635, 27099, 3, 21995, 3062, 3212, 2746, 3530, 16453, 2894, 1920, 2459, 1927, 8685, 12813, 8635, 27099, 16, 1925, 4595, 17, 22, 7829, 16, 1958, 1920, 2311, 1927, 3]}, "items": [{"id": "p_1394", "content": "tizanidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8685, 12813, 8635, 27099, 3, 3]}]}
{"query": {"id": "q_1395", "content": "kidney disease [SEP] illary basement membrane reduplication in allografts and native kidney disease: a clinicopathologic study of 278 consecutive renal specimens.", "tokenized_content": [2, 5245, 2573, 3, 3652, 2141, 16702, 3260, 2312, 3481, 3742, 1943, 1922, 24652, 1930, 6196, 5245, 2573, 30, 43, 26223, 2161, 1927, 21928, 7351, 4604, 5864, 18, 3]}, "items": [{"id": "p_1395", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1396", "content": "transplant glomerulopathy [SEP] BACKGROUND: An association has been found between transplant glomerulopathy (TG) and reduplication of peritubular capillary basement membra", "tokenized_content": [2, 5192, 19268, 6522, 3, 3872, 30, 1925, 3279, 2258, 2252, 2435, 2192, 5192, 19268, 6522, 12, 6030, 13, 1930, 2312, 3481, 3742, 1943, 1927, 2953, 1031, 2255, 2168, 9623, 16702, 3]}, "items": [{"id": "p_1396", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1397", "content": "TG [SEP] n association has been found between transplant glomerulopathy (TG) and reduplication of peritubular capillary basement membranes ", "tokenized_content": [2, 6030, 3, 56, 3279, 2258, 2252, 2435, 2192, 5192, 19268, 6522, 12, 6030, 13, 1930, 2312, 3481, 3742, 1943, 1927, 2953, 1031, 2255, 2168, 9623, 16702, 5726, 3]}, "items": [{"id": "p_1397", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1398", "content": "glomerulonephritis [SEP] ith TG, we also examined grafts with acute rejection, recurrent glomerulonephritis, chronic allograft nephropathy and stable grafts (\"protocol bio", "tokenized_content": [2, 27057, 3, 24737, 6030, 16, 2038, 2222, 3572, 12215, 1956, 3939, 10820, 16, 7457, 27057, 16, 3724, 15941, 15582, 1930, 4700, 12215, 12, 6, 4478, 3718, 3]}, "items": [{"id": "p_1398", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_1399", "content": "chronic allograft nephropathy [SEP] ined grafts with acute rejection, recurrent glomerulonephritis, chronic allograft nephropathy and stable grafts (\"protocol biopsies\"). Native kidney specimen", "tokenized_content": [2, 3724, 15941, 15582, 3, 11116, 1007, 12215, 1956, 3939, 10820, 16, 7457, 27057, 16, 3724, 15941, 15582, 1930, 4700, 12215, 12, 6, 4478, 9782, 6, 13, 18, 6196, 5245, 9339, 3]}, "items": [{"id": "p_1399", "content": "Renal Insufficiency, Chronic [SEP] Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is class", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 16, 3724, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1958, 2253, 2254, 2559, 3221, 18, 3724, 5245, 14566, 1977, 2921, 3]}]}
{"query": {"id": "q_1400", "content": "glomerulopathies [SEP] ol biopsies\"). Native kidney specimens included a wide range of glomerulopathies as well as cases of thrombotic microangiopathy, malignant hyper", "tokenized_content": [2, 19268, 16038, 3, 2865, 9782, 6, 13, 18, 6196, 5245, 5864, 3063, 43, 4743, 3109, 1927, 19268, 16038, 1966, 2486, 1966, 2919, 1927, 21039, 2703, 9506, 6522, 16, 6558, 4194, 3]}, "items": [{"id": "p_1400", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1401", "content": "thrombotic microangiopathy [SEP] s included a wide range of glomerulopathies as well as cases of thrombotic microangiopathy, malignant hypertension, acute interstitial nephritis, and acut", "tokenized_content": [2, 21039, 2703, 9506, 6522, 3, 61, 3063, 43, 4743, 3109, 1927, 19268, 16038, 1966, 2486, 1966, 2919, 1927, 21039, 2703, 9506, 6522, 16, 6558, 5579, 16, 3939, 11584, 25064, 16, 3]}, "items": [{"id": "p_1401", "content": "Thrombotic Microangiopathies [SEP] Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC", "score": 1, "type": null, "tokenized_content": [2, 21039, 2703, 9506, 16038, 3, 3902, 1988, 3211, 1922, 11354, 1922, 14264, 27795, 18, 1920, 2288, 2501, 8753, 3902, 2032, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3]}]}
{"query": {"id": "q_1402", "content": "malignant hypertension [SEP] lomerulopathies as well as cases of thrombotic microangiopathy, malignant hypertension, acute interstitial nephritis, and acute tubular necrosis. RESU", "tokenized_content": [2, 6558, 5579, 3, 3004, 9213, 1944, 16038, 1966, 2486, 1966, 2919, 1927, 21039, 2703, 9506, 6522, 16, 6558, 5579, 16, 3939, 11584, 25064, 16, 1930, 3939, 11755, 7476, 18, 1995, 3]}, "items": [{"id": "p_1402", "content": "Hypertension, Malignant [SEP] A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension i", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 6558, 3, 43, 2625, 1927, 7686, 4664, 2877, 3772, 1956, 9395, 3772, 5394, 3430, 2254, 6103, 2489, 7175, 18, 6558, 5579, 51, 3]}]}
{"query": {"id": "q_1403", "content": "interstitial nephritis [SEP] es of thrombotic microangiopathy, malignant hypertension, acute interstitial nephritis, and acute tubular necrosis. RESULTS: We found PTCR in 14 of 15", "tokenized_content": [2, 11584, 25064, 3, 2376, 1927, 21039, 2703, 9506, 6522, 16, 6558, 5579, 16, 3939, 11584, 25064, 16, 1930, 3939, 11755, 7476, 18, 2274, 30, 2038, 2435, 15611, 1005, 1922, 2607, 3]}, "items": [{"id": "p_1403", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_1404", "content": "acute tubular necrosis [SEP] athy, malignant hypertension, acute interstitial nephritis, and acute tubular necrosis. RESULTS: We found PTCR in 14 of 15 cases of TG, in 7 transplan", "tokenized_content": [2, 3939, 11755, 7476, 3, 9468, 1012, 16, 6558, 5579, 16, 3939, 11584, 25064, 16, 1930, 3939, 11755, 7476, 18, 2274, 30, 2038, 2435, 15611, 1005, 1922, 2607, 1927, 2461, 2919, 3]}, "items": [{"id": "p_1404", "content": "Kidney Tubular Necrosis, Acute [SEP] Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure", "score": 1, "type": null, "tokenized_content": [2, 5245, 11755, 7476, 16, 3939, 3, 3939, 5245, 4574, 3864, 2037, 12102, 1927, 4944, 2094, 1927, 1920, 5245, 14876, 18, 2176, 1977, 5384, 6898, 1942, 3395, 3]}]}
{"query": {"id": "q_1405", "content": "lupus nephritis [SEP] ed cases of malignant hypertension, thrombotic microangiopathy, lupus nephritis, Henoch-Schonlein nephritis, crescentic glomerulonephritis, and", "tokenized_content": [2, 13711, 25064, 3, 3347, 2919, 1927, 6558, 5579, 16, 21039, 2703, 9506, 6522, 16, 13711, 25064, 16, 14618, 2694, 17, 2966, 1916, 28875, 1022, 25064, 16, 18401, 3025, 1935, 27057, 3]}, "items": [{"id": "p_1405", "content": "Lupus Nephritis [SEP] Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified", "score": 1, "type": null, "tokenized_content": [2, 13711, 25064, 3, 27057, 2458, 1956, 8904, 2573, 5510, 13711, 22045, 18, 13711, 25064, 1977, 15055, 5947, 3]}]}
{"query": {"id": "q_1406", "content": "Henoch-Schonlein nephritis [SEP] nant hypertension, thrombotic microangiopathy, lupus nephritis, Henoch-Schonlein nephritis, crescentic glomerulonephritis, and cocaine-related acute renal", "tokenized_content": [2, 14618, 2694, 17, 2966, 1916, 28875, 1022, 25064, 3, 3529, 1031, 5579, 16, 21039, 2703, 9506, 6522, 16, 13711, 25064, 16, 14618, 2694, 17, 2966, 1916, 28875, 1022, 25064, 16, 3]}, "items": [{"id": "p_1406", "content": "Purpura, Schoenlein-Henoch [SEP] A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES ", "score": 1, "type": null, "tokenized_content": [2, 25945, 9280, 16, 2966, 6802, 20523, 14818, 17, 14618, 2694, 3, 43, 5510, 2447, 17, 15864, 4907, 19730, 25945, 9280, 4189, 2007, 14625, 21548, 1930, 7860, 1927, 12114, 17, 3165, 3743, 5048, 3]}]}
{"query": {"id": "q_1407", "content": "cocaine [SEP]  Henoch-Schonlein nephritis, crescentic glomerulonephritis, and cocaine-related acute renal failure. Mild PTCR in allografts without TG", "tokenized_content": [2, 9045, 3, 14618, 2694, 17, 2966, 1916, 28875, 1022, 25064, 16, 18401, 3025, 1935, 27057, 16, 1930, 9045, 17, 2712, 3939, 4604, 4574, 18, 5809, 15611, 1005, 1922, 24652, 2979, 3]}, "items": [{"id": "p_1407", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1408", "content": "acute renal failure [SEP] n nephritis, crescentic glomerulonephritis, and cocaine-related acute renal failure. Mild PTCR in allografts without TG did not predict renal failu", "tokenized_content": [2, 3939, 4604, 4574, 3, 56, 25064, 16, 18401, 3025, 1935, 27057, 16, 1930, 9045, 17, 2712, 3939, 4604, 4574, 18, 5809, 15611, 1005, 1922, 24652, 2979, 6030, 2811, 2084, 5660, 3]}, "items": [{"id": "p_1408", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_1409", "content": "renal failure [SEP] ritis, crescentic glomerulonephritis, and cocaine-related acute renal failure. Mild PTCR in allografts without TG did not predict renal failu", "tokenized_content": [2, 4604, 4574, 3, 24019, 1937, 16, 18401, 3025, 1935, 27057, 16, 1930, 9045, 17, 2712, 3939, 4604, 4574, 18, 5809, 15611, 1005, 1922, 24652, 2979, 6030, 2811, 2084, 5660, 4604, 3]}, "items": [{"id": "p_1409", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_1410", "content": "proteinuria [SEP] ografts without TG did not predict renal failure or significant proteinuria after follow-up periods of between 3 months and 1 year. CONCLUS", "tokenized_content": [2, 15831, 3, 17395, 5524, 24899, 2979, 6030, 2811, 2084, 5660, 4604, 4574, 2014, 2228, 15831, 2256, 2396, 17, 2353, 6696, 1927, 2192, 23, 3221, 1930, 21, 2476, 18, 3008, 1957, 3]}, "items": [{"id": "p_1410", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_1411", "content": "kidney diseases [SEP] he absence of TG is unclear. PTCR also occurs in certain native kidney diseases, though the association is not as strong as that for TG. We sug", "tokenized_content": [2, 5245, 3902, 3, 2234, 3905, 1927, 6030, 1977, 6390, 18, 15611, 1005, 2222, 5110, 1922, 4908, 6196, 5245, 3902, 16, 4170, 1920, 3279, 1977, 2084, 1966, 3206, 1966, 1988, 1958, 3]}, "items": [{"id": "p_1411", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1412", "content": "endothelial injury [SEP] ation is not as strong as that for TG. We suggest that repeated endothelial injury, including immunologic injury, may be the cause of this lesion ", "tokenized_content": [2, 5003, 4047, 3, 2019, 2001, 1977, 2084, 1966, 3206, 1966, 1988, 1958, 6030, 18, 2038, 3220, 1988, 5116, 5003, 4047, 16, 2710, 21049, 4047, 16, 2278, 1998, 1920, 3936, 1927, 3]}, "items": [{"id": "p_1412", "content": "Wounds and Injuries [SEP] Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural con", "score": 1, "type": null, "tokenized_content": [2, 14107, 1930, 8209, 3, 4293, 2552, 5847, 1919, 1990, 1920, 3362, 1966, 1920, 3083, 2014, 6354, 3211, 1927, 1925, 5771, 5495, 16, 1956, 2014, 2979, 7561, 1927, 4346, 1962, 3]}]}
{"query": {"id": "q_1413", "content": "immunologic injury [SEP]  for TG. We suggest that repeated endothelial injury, including immunologic injury, may be the cause of this lesion both in allografts and native ", "tokenized_content": [2, 21049, 4047, 3, 1958, 6030, 18, 2038, 3220, 1988, 5116, 5003, 4047, 16, 2710, 21049, 4047, 16, 2278, 1998, 1920, 3936, 1927, 2052, 5709, 2321, 1922, 24652, 1930, 6196, 3]}, "items": [{"id": "p_1413", "content": "Immune System Diseases [SEP] Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3743, 2433, 3902, 3, 4414, 4189, 2007, 4552, 2014, 7685, 21049, 3531, 16, 3053, 16601, 16, 2024, 17, 3434, 16, 2014, 2321, 18, 3]}]}
{"query": {"id": "q_1414", "content": "BD1008 [SEP] Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptor", "tokenized_content": [2, 5238, 9029, 1025, 3, 8523, 1954, 6715, 13204, 1927, 5238, 9029, 1025, 1930, 1925, 11645, 15039, 3695, 7221, 1022, 15274, 5133, 5139, 1009, 3148, 3]}, "items": [{"id": "p_1414", "content": "BD 1008 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5238, 2813, 1025, 3, 3]}]}
{"query": {"id": "q_1415", "content": "oligodeoxynucleotide [SEP] Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice", "tokenized_content": [2, 15039, 3695, 7221, 1022, 15274, 3, 8523, 1954, 6715, 13204, 1927, 5238, 9029, 1025, 1930, 1925, 11645, 15039, 3695, 7221, 1022, 15274, 5133, 5139, 1009, 4086, 5074, 2246, 17, 9045, 3]}, "items": [{"id": "p_1415", "content": "Oligodeoxyribonucleotides [SEP] A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming", "score": 1, "type": null, "tokenized_content": [2, 15039, 3695, 7221, 3027, 20226, 25513, 3, 43, 2210, 1927, 26405, 5551, 7314, 12, 2353, 1942, 2369, 13, 1922, 2154, 1920, 5413, 4248, 1927, 2362, 26405, 5551, 4749, 4033, 1966, 18142, 1922, 7402, 3]}]}
{"query": {"id": "q_1416", "content": "cocaine [SEP] se oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice.", "tokenized_content": [2, 9045, 3, 2058, 15039, 3695, 7221, 1022, 15274, 5133, 5139, 1009, 4086, 5074, 2246, 17, 9045, 2564, 1922, 2518, 18, 3]}, "items": [{"id": "p_1416", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1417", "content": "Cocaine [SEP] Cocaine's ability to interact with sigma receptors suggests that these ", "tokenized_content": [2, 9045, 3, 9045, 11, 61, 3682, 1942, 6310, 1956, 5139, 4086, 4015, 1988, 2144, 3]}, "items": [{"id": "p_1417", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1418", "content": "BD1063 [SEP] 1-[2-(3,4-dichlorophenyl)ethyl]-1,4-diazabicyclo[4.3.0]nonane), BD1063 (1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine), and LR132", "tokenized_content": [2, 5238, 16551, 1010, 3, 21, 17, 37, 22, 17, 12, 23, 16, 24, 17, 29105, 17616, 2199, 13, 7843, 39, 17, 21, 16, 24, 17, 19106, 28808, 22170, 1037, 37, 3]}, "items": [{"id": "p_1418", "content": "1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 12, 22, 17, 12, 23, 16, 24, 17, 29105, 17616, 2199, 13, 7843, 13, 17, 24, 17, 4963, 10984, 2116, 10119, 3, 3]}]}
{"query": {"id": "q_1419", "content": "1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine [SEP] 4-dichlorophenyl)ethyl]-1,4-diazabicyclo[4.3.0]nonane), BD1063 (1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine), and LR132 (1R,2S-(+)-cis-N-[2-(3,4-dichlorophenyl)ethyl]-2-(1", "tokenized_content": [2, 21, 17, 37, 22, 17, 12, 23, 16, 24, 17, 29105, 17616, 2199, 13, 7843, 39, 17, 24, 17, 4963, 10984, 2116, 10119, 3, 24, 17, 29105, 17616, 2199, 13, 3]}, "items": [{"id": "p_1419", "content": "1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 12, 22, 17, 12, 23, 16, 24, 17, 29105, 17616, 2199, 13, 7843, 13, 17, 24, 17, 4963, 10984, 2116, 10119, 3, 3]}]}
{"query": {"id": "q_1420", "content": "dopamine [SEP] ties for sigma2 receptors and exhibit negligible affinities for dopamine, opioid, GABA(A) and NMDA receptors. In behavioral studies, pre", "tokenized_content": [2, 7964, 3, 25439, 1958, 5139, 1028, 4086, 1930, 5987, 12613, 15377, 1958, 7964, 16, 9384, 16, 7992, 12, 43, 13, 1930, 10976, 4086, 18, 1922, 5343, 2351, 16, 2097, 3]}, "items": [{"id": "p_1420", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1421", "content": "GABA [SEP] ceptors and exhibit negligible affinities for dopamine, opioid, GABA(A) and NMDA receptors. In behavioral studies, pre-treatment of ", "tokenized_content": [2, 7992, 3, 17008, 3448, 1930, 5987, 12613, 15377, 1958, 7964, 16, 9384, 16, 7992, 12, 43, 13, 1930, 10976, 4086, 18, 1922, 5343, 2351, 16, 2097, 17, 2311, 1927, 3]}, "items": [{"id": "p_1421", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1422", "content": "NMDA [SEP] exhibit negligible affinities for dopamine, opioid, GABA(A) and NMDA receptors. In behavioral studies, pre-treatment of mice with BD", "tokenized_content": [2, 10976, 3, 5987, 12613, 15377, 1958, 7964, 16, 9384, 16, 7992, 12, 43, 13, 1930, 10976, 4086, 18, 1922, 5343, 2351, 16, 2097, 17, 2311, 1927, 2518, 1956, 5238, 3]}, "items": [{"id": "p_1422", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_1423", "content": "cocaine [SEP]  of mice with BD1018, BD1063, or LR132 significantly attenuated cocaine-induced convulsions and lethality. Moreover, post-treatment wit", "tokenized_content": [2, 9045, 3, 1927, 2518, 1956, 5238, 13100, 1025, 16, 5238, 16551, 1010, 16, 2014, 7146, 15288, 2567, 8060, 9045, 17, 2719, 4772, 19389, 1930, 15400, 18, 3950, 16, 2753, 17, 3]}, "items": [{"id": "p_1423", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1424", "content": "convulsions [SEP] 1018, BD1063, or LR132 significantly attenuated cocaine-induced convulsions and lethality. Moreover, post-treatment with LR132 prevented co", "tokenized_content": [2, 4772, 19389, 3, 9447, 1025, 16, 5238, 16551, 1010, 16, 2014, 7146, 15288, 2567, 8060, 9045, 17, 2719, 4772, 19389, 1930, 15400, 18, 3950, 16, 2753, 17, 2311, 1956, 7146, 3]}, "items": [{"id": "p_1424", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1425", "content": "di-o-tolylguanidine [SEP] tive antagonists, the well-characterized sigma receptor agonist di-o-tolylguanidine (DTG) and the novel sigma receptor agonist BD1031 (3R-1-[2-(3,4", "tokenized_content": [2, 2137, 17, 57, 17, 21930, 2199, 11056, 8150, 27099, 3, 8685, 1961, 10515, 16, 1920, 2486, 17, 4378, 5139, 3148, 7829, 2137, 17, 57, 17, 21930, 2199, 11056, 8150, 27099, 3]}, "items": [{"id": "p_1425", "content": "1,3-ditolylguanidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 16, 23, 17, 2137, 4575, 14509, 11056, 8150, 27099, 3, 3]}]}
{"query": {"id": "q_1426", "content": "DTG [SEP]  well-characterized sigma receptor agonist di-o-tolylguanidine (DTG) and the novel sigma receptor agonist BD1031 (3R-1-[2-(3,4-dich", "tokenized_content": [2, 7711, 1029, 3, 2486, 17, 4378, 5139, 3148, 7829, 2137, 17, 57, 17, 21930, 2199, 11056, 8150, 27099, 12, 7711, 1029, 13, 1930, 1920, 4008, 5139, 3148, 7829, 5238, 14726, 3]}, "items": [{"id": "p_1426", "content": "1,3-ditolylguanidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 16, 23, 17, 2137, 4575, 14509, 11056, 8150, 27099, 3, 3]}]}
{"query": {"id": "q_1427", "content": "toxicity [SEP] yl]-1,4-diazabicyclo[4.3.0]nonane) each worsened the behavioral toxicity of cocaine. At doses where alone, they produced no significant ", "tokenized_content": [2, 5532, 3, 12111, 39, 17, 21, 16, 24, 17, 19106, 28808, 22170, 1037, 37, 24, 18, 23, 18, 20, 39, 2447, 2516, 13, 2362, 22784, 1920, 5343, 5532, 1927, 9045, 3]}, "items": [{"id": "p_1427", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1428", "content": "oligodeoxynucleotide [SEP] el ligands involved antagonism of sigma receptors, an antisense oligodeoxynucleotide against sigma1 receptors was also shown to significantly attenu", "tokenized_content": [2, 15039, 3695, 7221, 1022, 15274, 3, 2349, 6908, 3286, 18394, 1927, 5139, 4086, 16, 1925, 11645, 15039, 3695, 7221, 1022, 15274, 3316, 5139, 1009, 4086, 1982, 2222, 2522, 1942, 2567, 3]}, "items": [{"id": "p_1428", "content": "Oligodeoxyribonucleotides [SEP] A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming", "score": 1, "type": null, "tokenized_content": [2, 15039, 3695, 7221, 3027, 20226, 25513, 3, 43, 2210, 1927, 26405, 5551, 7314, 12, 2353, 1942, 2369, 13, 1922, 2154, 1920, 5413, 4248, 1927, 2362, 26405, 5551, 4749, 4033, 1966, 18142, 1922, 7402, 3]}]}
{"query": {"id": "q_1429", "content": "convulsive [SEP]  sigma1 receptors was also shown to significantly attenuate the convulsive and locomotor stimulatory effects of cocaine. Together, the dat", "tokenized_content": [2, 4772, 13042, 3, 5139, 1009, 4086, 1982, 2222, 2522, 1942, 2567, 15500, 1920, 4772, 13042, 1930, 13594, 14971, 2564, 1927, 9045, 18, 4084, 16, 1920, 2181, 3]}, "items": [{"id": "p_1429", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1430", "content": "E4031 [SEP] Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action pot", "tokenized_content": [2, 18157, 12962, 1009, 3, 12763, 19, 24358, 4076, 1927, 1920, 2564, 1927, 18157, 12962, 1009, 16, 5848, 21358, 2261, 16, 6005, 14946, 22650, 1930, 6005, 11498, 2053, 1990, 20401, 11316, 3]}, "items": [{"id": "p_1430", "content": "E 4031 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 47, 28136, 1009, 3, 3]}]}
{"query": {"id": "q_1431", "content": "cisapride [SEP] macokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential dura", "tokenized_content": [2, 5848, 21358, 2261, 3, 3433, 28731, 19, 24358, 4076, 1927, 1920, 2564, 1927, 18157, 12962, 1009, 16, 5848, 21358, 2261, 16, 6005, 14946, 22650, 1930, 6005, 11498, 2053, 1990, 20401, 3]}, "items": [{"id": "p_1431", "content": "Cisapride [SEP] A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, fun", "score": 1, "type": null, "tokenized_content": [2, 5848, 21358, 2261, 3, 43, 11798, 7334, 5482, 2251, 1958, 2496, 1965, 24590, 2002, 3879, 18, 2176, 1977, 2251, 1922, 1920, 4280, 1927, 28933, 13583, 2573, 16, 2277, 3]}]}
{"query": {"id": "q_1432", "content": "terfenadine [SEP] /pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog.", "tokenized_content": [2, 6005, 14946, 22650, 3, 19, 24358, 4076, 1927, 1920, 2564, 1927, 18157, 12962, 1009, 16, 5848, 21358, 2261, 16, 6005, 14946, 22650, 1930, 6005, 11498, 2053, 1990, 20401, 11316, 4615, 3]}, "items": [{"id": "p_1432", "content": "Terfenadine [SEP] A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY", "score": 1, "type": null, "tokenized_content": [2, 6005, 14946, 22650, 3, 43, 5328, 14622, 9169, 17, 3148, 8151, 18327, 1927, 4101, 7580, 2433, 20852, 2031, 2455, 18, 1920, 2838, 1982, 2251, 1958, 13255, 3]}]}
{"query": {"id": "q_1433", "content": "terodiline [SEP]  assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog.", "tokenized_content": [2, 6005, 11498, 2053, 3, 4076, 1927, 1920, 2564, 1927, 18157, 12962, 1009, 16, 5848, 21358, 2261, 16, 6005, 14946, 22650, 1930, 6005, 11498, 2053, 1990, 20401, 11316, 4615, 2889, 4392, 3]}, "items": [{"id": "p_1433", "content": "terodiline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6005, 11498, 2053, 3, 3]}]}
{"query": {"id": "q_1434", "content": "Torsades de pointes [SEP] 1. Torsades de pointes (TDP) is a potentially fatal ventricular tachycardia associated", "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 21, 18, 14823, 6363, 2028, 3575, 1918, 12, 15390, 13, 1977, 43, 5063, 11990, 6493, 17397, 2458, 3]}, "items": [{"id": "p_1434", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_1435", "content": "TDP [SEP] 1. Torsades de pointes (TDP) is a potentially fatal ventricular tachycardia associated with", "tokenized_content": [2, 15390, 3, 21, 18, 14823, 6363, 2028, 3575, 1918, 12, 15390, 13, 1977, 43, 5063, 11990, 6493, 17397, 2458, 1956, 3]}, "items": [{"id": "p_1435", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_1436", "content": "ventricular tachycardia [SEP] 1. Torsades de pointes (TDP) is a potentially fatal ventricular tachycardia associated with increases in QT interval and monophasic action ", "tokenized_content": [2, 6493, 17397, 3, 21, 18, 14823, 6363, 2028, 3575, 1918, 12, 15390, 13, 1977, 43, 5063, 11990, 6493, 17397, 2458, 1956, 4041, 1922, 8877, 4979, 1930, 20401, 11316, 4615, 3]}, "items": [{"id": "p_1436", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_1437", "content": "terfenadine [SEP] at has led to withdrawal of several drugs from the market (e.g. terfenadine and terodiline). 2. The potential of compounds to cause TDP was", "tokenized_content": [2, 6005, 14946, 22650, 3, 2019, 2258, 4866, 1942, 9594, 1927, 2980, 4195, 2037, 1920, 10878, 12, 47, 18, 49, 18, 6005, 14946, 22650, 1930, 6005, 11498, 2053, 13, 18, 22, 3]}, "items": [{"id": "p_1437", "content": "Terfenadine [SEP] A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY", "score": 1, "type": null, "tokenized_content": [2, 6005, 14946, 22650, 3, 43, 5328, 14622, 9169, 17, 3148, 8151, 18327, 1927, 4101, 7580, 2433, 20852, 2031, 2455, 18, 1920, 2838, 1982, 2251, 1958, 13255, 3]}]}
{"query": {"id": "q_1438", "content": "terodiline [SEP] thdrawal of several drugs from the market (e.g. terfenadine and terodiline). 2. The potential of compounds to cause TDP was evaluated by m", "tokenized_content": [2, 6005, 11498, 2053, 3, 1913, 8049, 1923, 1927, 2980, 4195, 2037, 1920, 10878, 12, 47, 18, 49, 18, 6005, 14946, 22650, 1930, 6005, 11498, 2053, 13, 18, 22, 18, 1920, 3]}, "items": [{"id": "p_1438", "content": "terodiline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6005, 11498, 2053, 3, 3]}]}
{"query": {"id": "q_1439", "content": "cisapride [SEP] erval and cause TDP were investigated: terfenadine, terodiline, cisapride and E4031. On the basis that only free drug in the systemic cir", "tokenized_content": [2, 5848, 21358, 2261, 3, 2668, 4701, 1930, 3936, 15390, 1985, 3845, 30, 6005, 14946, 22650, 16, 6005, 11498, 2053, 16, 5848, 21358, 2261, 1930, 18157, 12962, 1009, 18, 1990, 1920, 3]}, "items": [{"id": "p_1439", "content": "Cisapride [SEP] A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, fun", "score": 1, "type": null, "tokenized_content": [2, 5848, 21358, 2261, 3, 43, 11798, 7334, 5482, 2251, 1958, 2496, 1965, 24590, 2002, 3879, 18, 2176, 1977, 2251, 1922, 1920, 4280, 1927, 28933, 13583, 2573, 16, 2277, 3]}]}
{"query": {"id": "q_1440", "content": "E4031 [SEP] e TDP were investigated: terfenadine, terodiline, cisapride and E4031. On the basis that only free drug in the systemic circulation w", "tokenized_content": [2, 18157, 12962, 1009, 3, 47, 15390, 1985, 3845, 30, 6005, 14946, 22650, 16, 6005, 11498, 2053, 16, 5848, 21358, 2261, 1930, 18157, 12962, 1009, 18, 1990, 1920, 4859, 1988, 2444, 3]}, "items": [{"id": "p_1440", "content": "E 4031 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 47, 28136, 1009, 3, 3]}]}
{"query": {"id": "q_1441", "content": "myeloencephalopathy [SEP] Fatal myeloencephalopathy due to accidental intrathecal vincristin administration: a repo", "tokenized_content": [2, 5707, 29159, 6522, 3, 11990, 5707, 29159, 6522, 2810, 1942, 24842, 22782, 25297, 23351, 4183, 30, 43, 3073, 1037, 3]}, "items": [{"id": "p_1441", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_1442", "content": "vincristin [SEP] Fatal myeloencephalopathy due to accidental intrathecal vincristin administration: a report of two cases.", "tokenized_content": [2, 25297, 23351, 3, 11990, 5707, 29159, 6522, 2810, 1942, 24842, 22782, 25297, 23351, 4183, 30, 43, 3809, 1927, 2288, 2919, 18, 3]}, "items": [{"id": "p_1442", "content": "Vincristine [SEP] Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)\n    ", "score": 1, "type": null, "tokenized_content": [2, 25446, 3, 11775, 29951, 3937, 2037, 24198, 1019, 13679, 1019, 18, 12, 14556, 16, 2513, 1963, 3347, 18, 13, 3]}]}
{"query": {"id": "q_1443", "content": "vincristine [SEP] We report on two fatal cases of accidental intrathecal vincristine instillation in a 5-year old girl with recurrent acute lymphobl", "tokenized_content": [2, 25446, 3, 2038, 3809, 1990, 2288, 11990, 2919, 1927, 24842, 22782, 25446, 24893, 1922, 43, 25, 17, 2476, 4156, 21676, 1956, 7457, 3939, 3541, 4658, 3]}, "items": [{"id": "p_1443", "content": "Vincristine [SEP] Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)\n    ", "score": 1, "type": null, "tokenized_content": [2, 25446, 3, 11775, 29951, 3937, 2037, 24198, 1019, 13679, 1019, 18, 12, 14556, 16, 2513, 1963, 3347, 18, 13, 3]}]}
{"query": {"id": "q_1444", "content": "acute lymphoblastic leucemia [SEP] al vincristine instillation in a 5-year old girl with recurrent acute lymphoblastic leucemia and a 57-year old man with lymphoblastic lymphoma. The girl die", "tokenized_content": [2, 3939, 24403, 9906, 3847, 3, 1969, 25446, 24893, 1922, 43, 25, 17, 2476, 4156, 21676, 1956, 7457, 3939, 24403, 9906, 3847, 1930, 43, 4786, 17, 2476, 4156, 2323, 1956, 24403, 3]}, "items": [{"id": "p_1444", "content": "Precursor Cell Lymphoblastic Leukemia-Lymphoma [SEP] A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and ot", "score": 1, "type": null, "tokenized_content": [2, 7897, 2024, 24403, 8111, 17, 8636, 3, 43, 12132, 4378, 2007, 6754, 1927, 1920, 11751, 2024, 10416, 4523, 1942, 9122, 3541, 10088, 1922, 1920, 6599, 1930, 7608, 3]}]}
{"query": {"id": "q_1445", "content": "lymphoblastic lymphoma [SEP] current acute lymphoblastic leucemia and a 57-year old man with lymphoblastic lymphoma. The girl died seven days, the man four weeks after intrathecal", "tokenized_content": [2, 24403, 8636, 3, 3214, 3939, 24403, 9906, 3847, 1930, 43, 4786, 17, 2476, 4156, 2323, 1956, 24403, 8636, 18, 1920, 21676, 8545, 5260, 3000, 16, 1920, 2323, 3006, 3625, 2256, 3]}, "items": [{"id": "p_1445", "content": "Precursor Cell Lymphoblastic Leukemia-Lymphoma [SEP] A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and ot", "score": 1, "type": null, "tokenized_content": [2, 7897, 2024, 24403, 8111, 17, 8636, 3, 43, 12132, 4378, 2007, 6754, 1927, 1920, 11751, 2024, 10416, 4523, 1942, 9122, 3541, 10088, 1922, 1920, 6599, 1930, 7608, 3]}]}
{"query": {"id": "q_1446", "content": "motor dysfunction [SEP] set was characterized by the signs of opistothonus, sensory and motor dysfunction and ascending paralysis. Histological and immunohistochemical i", "tokenized_content": [2, 4842, 5273, 3, 2735, 1982, 4378, 2007, 1920, 6879, 1927, 7976, 2156, 25523, 1022, 1957, 16, 6893, 1930, 4842, 5273, 1930, 15871, 18973, 18, 6791, 1930, 9885, 51, 3]}, "items": [{"id": "p_1446", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_1447", "content": "paralysis [SEP] ns of opistothonus, sensory and motor dysfunction and ascending paralysis. Histological and immunohistochemical investigations (HE-LFB, C", "tokenized_content": [2, 18973, 3, 4246, 1927, 7976, 2156, 25523, 1022, 1957, 16, 6893, 1930, 4842, 5273, 1930, 15871, 18973, 18, 6791, 1930, 9885, 7873, 12, 2234, 17, 11048, 1014, 16, 45, 3]}, "items": [{"id": "p_1447", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_1448", "content": "degeneration of myelin [SEP] chemical investigations (HE-LFB, CD-68, Neurofilament) revealed degeneration of myelin and axons as well as pseudocystic transformation in areas expos", "tokenized_content": [2, 9174, 1927, 12996, 3, 4399, 7873, 12, 2234, 17, 11048, 1014, 16, 2464, 17, 5117, 16, 19200, 19167, 2017, 13, 3404, 9174, 1927, 12996, 1930, 9725, 1966, 2486, 1966, 11520, 3]}, "items": [{"id": "p_1448", "content": "Demyelinating Diseases [SEP] Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29340, 3902, 3, 3902, 4378, 2007, 3257, 2014, 5273, 1927, 12996, 1922, 1920, 4101, 2014, 5009, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1449", "content": "prochlorperazine [SEP] Intravenous administration of prochlorperazine by 15-minute infusion versus 2-minute bolus does not affect the", "tokenized_content": [2, 9823, 7806, 12157, 7124, 22030, 2912, 3, 7307, 4183, 1927, 9823, 7806, 12157, 7124, 22030, 2912, 2007, 2461, 17, 8623, 7386, 4072, 22, 17, 8623, 14840, 3731, 2084, 4081, 1920, 3]}, "items": [{"id": "p_1449", "content": "Prochlorperazine [SEP] A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPR", "score": 1, "type": null, "tokenized_content": [2, 9823, 7806, 12157, 7124, 22030, 2912, 3, 43, 3037, 30354, 2053, 17581, 2251, 22581, 1922, 1920, 2311, 1927, 13759, 31, 13954, 31, 1930, 3566, 28870, 18, 2176, 1977, 2253, 3205, 2254, 4891, 2047, 3]}]}
{"query": {"id": "q_1450", "content": "akathisia [SEP] infusion versus 2-minute bolus does not affect the incidence of akathisia: a prospective, randomized, controlled trial.", "tokenized_content": [2, 4464, 2183, 1937, 2126, 3, 7386, 4072, 22, 17, 8623, 14840, 3731, 2084, 4081, 1920, 4332, 1927, 4464, 2183, 1937, 2126, 30, 43, 6315, 16, 5542, 16, 4642, 3046, 18, 3]}, "items": [{"id": "p_1450", "content": "Akathisia, Drug-Induced [SEP] A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often de", "score": 1, "type": null, "tokenized_content": [2, 4464, 2183, 1937, 2126, 16, 2838, 17, 2719, 3, 43, 2625, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 1930, 4378, 2007, 1925, 4495, 7534, 1927, 4842, 6172, 26481, 3868, 2028, 3]}]}
{"query": {"id": "q_1451", "content": "akathisia [SEP] STUDY OBJECTIVE: We sought to compare the rate of akathisia after administration of intravenous prochlorperazine as a 2-min", "tokenized_content": [2, 4464, 2183, 1937, 2126, 3, 2161, 4470, 30, 2038, 8758, 1942, 5175, 1920, 2769, 1927, 4464, 2183, 1937, 2126, 2256, 4183, 1927, 7307, 9823, 7806, 12157, 7124, 22030, 2912, 1966, 3]}, "items": [{"id": "p_1451", "content": "Akathisia, Drug-Induced [SEP] A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often de", "score": 1, "type": null, "tokenized_content": [2, 4464, 2183, 1937, 2126, 16, 2838, 17, 2719, 3, 43, 2625, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 1930, 4378, 2007, 1925, 4495, 7534, 1927, 4842, 6172, 26481, 3868, 2028, 3]}]}
{"query": {"id": "q_1452", "content": "prochlorperazine [SEP] mpare the rate of akathisia after administration of intravenous prochlorperazine as a 2-minute bolus or 15-minute infusion. METHODS: We conducte", "tokenized_content": [2, 9823, 7806, 12157, 7124, 22030, 2912, 3, 12888, 1936, 1920, 2769, 1927, 4464, 2183, 1937, 2126, 2256, 4183, 1927, 7307, 9823, 7806, 12157, 7124, 22030, 2912, 1966, 43, 22, 17, 3]}, "items": [{"id": "p_1452", "content": "Prochlorperazine [SEP] A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPR", "score": 1, "type": null, "tokenized_content": [2, 9823, 7806, 12157, 7124, 22030, 2912, 3, 43, 3037, 30354, 2053, 17581, 2251, 22581, 1922, 1920, 2311, 1927, 13759, 31, 13954, 31, 1930, 3566, 28870, 18, 2176, 1977, 2253, 3205, 2254, 4891, 2047, 3]}]}
{"query": {"id": "q_1453", "content": "headache [SEP] tients aged 18 years or older treated with prochlorperazine for headache, nausea, or vomiting were eligible for inclusion. Study partici", "tokenized_content": [2, 12187, 3, 19108, 4905, 1036, 5177, 2654, 2739, 2014, 4706, 2868, 1956, 9823, 7806, 12157, 7124, 22030, 2912, 1958, 12187, 16, 13759, 16, 2014, 13954, 1985, 8526, 1958, 6125, 18, 3]}, "items": [{"id": "p_1453", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_1454", "content": "nausea [SEP] d 18 years or older treated with prochlorperazine for headache, nausea, or vomiting were eligible for inclusion. Study participants we", "tokenized_content": [2, 13759, 3, 46, 2654, 2739, 2014, 4706, 2868, 1956, 9823, 7806, 12157, 7124, 22030, 2912, 1958, 12187, 16, 13759, 16, 2014, 13954, 1985, 8526, 1958, 6125, 18, 2161, 3003, 2038, 3]}, "items": [{"id": "p_1454", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_1455", "content": "vomiting [SEP] or older treated with prochlorperazine for headache, nausea, or vomiting were eligible for inclusion. Study participants were randomized", "tokenized_content": [2, 13954, 3, 2014, 4706, 2868, 1956, 9823, 7806, 12157, 7124, 22030, 2912, 1958, 12187, 16, 13759, 16, 2014, 13954, 1985, 8526, 1958, 6125, 18, 2161, 3003, 1985, 5542, 3]}, "items": [{"id": "p_1455", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_1456", "content": "agitation [SEP] a was defined as either a spontaneous report of restlessness or agitation or a change of 2 or more in the patient-reported akathisia rati", "tokenized_content": [2, 18389, 3, 43, 1982, 3608, 1966, 3108, 43, 6242, 3809, 1927, 6172, 26481, 2014, 18389, 2014, 43, 3185, 1927, 22, 2014, 2253, 1922, 1920, 2774, 17, 2568, 4464, 2183, 1937, 3]}, "items": [{"id": "p_1456", "content": "Psychomotor Agitation [SEP] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug tox", "score": 1, "type": null, "tokenized_content": [2, 26261, 18389, 3, 43, 14452, 1927, 6172, 26481, 2458, 1956, 2502, 4842, 2455, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 7580, 2433, 2838, 3780, 3]}]}
{"query": {"id": "q_1457", "content": "Antithymocyte globulin [SEP] Antithymocyte globulin in the treatment of D-penicillamine-induced aplastic anemia.", "tokenized_content": [2, 10310, 30338, 12492, 27932, 1021, 24366, 3, 10310, 30338, 12492, 27932, 1021, 24366, 1922, 1920, 2311, 1927, 46, 17, 25142, 3812, 17, 2719, 18373, 4054, 10679, 18, 3]}, "items": [{"id": "p_1457", "content": "Antilymphocyte Serum [SEP] Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY ", "score": 1, "type": null, "tokenized_content": [2, 2246, 1954, 6588, 10647, 27932, 1021, 3256, 3, 3256, 3165, 7034, 17, 24366, 1036, 2154, 2032, 3788, 1958, 10009, 7769, 18, 2176, 1977, 2251, 2321, 1966, 43, 2648, 1958, 22836, 3]}]}
{"query": {"id": "q_1458", "content": "D-penicillamine [SEP] Antithymocyte globulin in the treatment of D-penicillamine-induced aplastic anemia.", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 10310, 30338, 12492, 27932, 1021, 24366, 1922, 1920, 2311, 1927, 46, 17, 25142, 3812, 17, 2719, 18373, 4054, 10679, 18, 3]}, "items": [{"id": "p_1458", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_1459", "content": "aplastic anemia [SEP] ithymocyte globulin in the treatment of D-penicillamine-induced aplastic anemia.", "tokenized_content": [2, 18373, 4054, 10679, 3, 24737, 2229, 4463, 24366, 1922, 1920, 2311, 1927, 46, 17, 25142, 3812, 17, 2719, 18373, 4054, 10679, 18, 3]}, "items": [{"id": "p_1459", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_1460", "content": "antithymocyte globulin [SEP] A patient who received antithymocyte globulin therapy for aplastic anemia due to D-penicillamine therapy is d", "tokenized_content": [2, 10310, 30338, 12492, 27932, 1021, 24366, 3, 43, 2774, 2746, 4004, 10310, 30338, 12492, 27932, 1021, 24366, 3181, 1958, 18373, 4054, 10679, 2810, 1942, 46, 17, 25142, 3812, 3181, 1977, 3]}, "items": [{"id": "p_1460", "content": "Antilymphocyte Serum [SEP] Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY ", "score": 1, "type": null, "tokenized_content": [2, 2246, 1954, 6588, 10647, 27932, 1021, 3256, 3, 3256, 3165, 7034, 17, 24366, 1036, 2154, 2032, 3788, 1958, 10009, 7769, 18, 2176, 1977, 2251, 2321, 1966, 43, 2648, 1958, 22836, 3]}]}
{"query": {"id": "q_1461", "content": "aplastic anemia [SEP] A patient who received antithymocyte globulin therapy for aplastic anemia due to D-penicillamine therapy is described. Bone marrow recove", "tokenized_content": [2, 18373, 4054, 10679, 3, 43, 2774, 2746, 4004, 10310, 30338, 12492, 27932, 1021, 24366, 3181, 1958, 18373, 4054, 10679, 2810, 1942, 46, 17, 25142, 3812, 3181, 1977, 2910, 18, 3622, 3]}, "items": [{"id": "p_1461", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_1462", "content": "D-penicillamine [SEP] eived antithymocyte globulin therapy for aplastic anemia due to D-penicillamine therapy is described. Bone marrow recovery and peripheral blood", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 16101, 2173, 10310, 30338, 12492, 27932, 1021, 24366, 3181, 1958, 18373, 4054, 10679, 2810, 1942, 46, 17, 25142, 3812, 3181, 1977, 2910, 18, 3622, 6599, 3]}, "items": [{"id": "p_1462", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_1463", "content": "acetylcholine [SEP] The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in withdrawal se", "tokenized_content": [2, 14561, 3, 1920, 3303, 2192, 7636, 14561, 4012, 1930, 13908, 4772, 6325, 2031, 3802, 1922, 9594, 2058, 3]}, "items": [{"id": "p_1463", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_1464", "content": "seizure [SEP] ne release and cholinergic convulsant sensitivity in withdrawal seizure-prone and withdrawal seizure-resistant selected mouse lines.", "tokenized_content": [2, 11015, 3, 2069, 4012, 1930, 13908, 4772, 6325, 2031, 3802, 1922, 9594, 11015, 17, 10424, 1930, 9594, 11015, 17, 4910, 3790, 3321, 3557, 18, 3]}, "items": [{"id": "p_1464", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1465", "content": "alcohol [SEP] s, but limited data are available on cholinergic involvement in alcohol withdrawal severity. Thus, the relationship between cholinergic", "tokenized_content": [2, 4284, 3, 61, 16, 2308, 3892, 2230, 2032, 3322, 1990, 13908, 5668, 1922, 4284, 9594, 5155, 18, 2842, 16, 1920, 3303, 2192, 13908, 3]}, "items": [{"id": "p_1465", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_1466", "content": "ethanol [SEP] lcohol withdrawal was investigated in a genetic animal model of ethanol withdrawal severity. METHODS: Cholinergic convulsant sensitivit", "tokenized_content": [2, 5757, 3, 5236, 2977, 1945, 9594, 1982, 3845, 1922, 43, 3299, 4027, 2322, 1927, 5757, 9594, 5155, 18, 2860, 30, 13908, 4772, 6325, 2031, 3532, 2165, 1031, 3]}, "items": [{"id": "p_1466", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_1467", "content": "Seizure [SEP] onvulsant sensitivity was examined in alcohol-na  ve Withdrawal Seizure-Prone (WSP) and-Resistant (WSR) mice. Animals were administered", "tokenized_content": [2, 11015, 3, 1990, 1020, 6325, 2031, 3802, 1982, 3572, 1922, 4284, 17, 4049, 3428, 9594, 11015, 17, 10424, 12, 12369, 1034, 13, 1930, 17, 4910, 12, 12369, 1005, 13, 2518, 3]}, "items": [{"id": "p_1467", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1468", "content": "nicotine [SEP] Prone (WSP) and-Resistant (WSR) mice. Animals were administered nicotine, carbachol, or neostigmine via timed tail vein infusion, and th", "tokenized_content": [2, 9303, 3, 10424, 12, 12369, 1034, 13, 1930, 17, 4910, 12, 12369, 1005, 13, 2518, 18, 3555, 1985, 5254, 9303, 16, 28940, 16, 2014, 11724, 2156, 29043, 2053, 3454, 22674, 3]}, "items": [{"id": "p_1468", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_1469", "content": "carbachol [SEP] ) and-Resistant (WSR) mice. Animals were administered nicotine, carbachol, or neostigmine via timed tail vein infusion, and the latencies", "tokenized_content": [2, 28940, 3, 13, 1930, 17, 4910, 12, 12369, 1005, 13, 2518, 18, 3555, 1985, 5254, 9303, 16, 28940, 16, 2014, 11724, 2156, 29043, 2053, 3454, 22674, 5281, 7920, 7386, 16, 3]}, "items": [{"id": "p_1469", "content": "Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28940, 3, 43, 11240, 21665, 13908, 7829, 1988, 8016, 2019, 2321, 20318, 1930, 20239, 4086, 18, 3]}]}
{"query": {"id": "q_1470", "content": "neostigmine [SEP] t (WSR) mice. Animals were administered nicotine, carbachol, or neostigmine via timed tail vein infusion, and the latencies to onset of tre", "tokenized_content": [2, 11724, 2156, 29043, 2053, 3, 62, 12, 12369, 1005, 13, 2518, 18, 3555, 1985, 5254, 9303, 16, 28940, 16, 2014, 11724, 2156, 29043, 2053, 3454, 22674, 5281, 7920, 7386, 16, 3]}, "items": [{"id": "p_1470", "content": "Neostigmine [SEP] A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gal", "score": 1, "type": null, "tokenized_content": [2, 11724, 2156, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 2251, 1922, 1920, 2311, 1927, 3057, 27618, 8572, 12413, 1937, 1930, 1942, 5267, 1920, 2564, 1927, 3760, 7327, 2356, 2427, 1966, 5179, 3]}]}
{"query": {"id": "q_1471", "content": "tremor [SEP] ine via timed tail vein infusion, and the latencies to onset of tremor and clonus were recorded and converted to threshold dose. We al", "tokenized_content": [2, 18388, 3, 11116, 3454, 22674, 5281, 7920, 7386, 16, 1930, 1920, 18604, 1942, 4727, 1927, 18388, 1930, 6138, 1957, 1985, 4562, 1930, 9076, 1942, 4683, 3253, 18, 2038, 1969, 3]}, "items": [{"id": "p_1471", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_1472", "content": "potassium [SEP] threshold dose. We also used microdialysis to measure basal and potassium-stimulated acetylcholine (ACh) release in the CA1 region of the", "tokenized_content": [2, 9057, 3, 4683, 3253, 18, 2038, 2222, 2251, 27162, 1942, 2931, 5342, 1930, 9057, 17, 5449, 14561, 12, 3546, 13, 4012, 1922, 1920, 12961, 3031, 1927, 1920, 3]}, "items": [{"id": "p_1472", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1473", "content": "acetylcholine [SEP] so used microdialysis to measure basal and potassium-stimulated acetylcholine (ACh) release in the CA1 region of the hippocampus. Potassium w", "tokenized_content": [2, 14561, 3, 2577, 2251, 27162, 1942, 2931, 5342, 1930, 9057, 17, 5449, 14561, 12, 3546, 13, 4012, 1922, 1920, 12961, 3031, 1927, 1920, 7661, 18, 9057, 65, 3]}, "items": [{"id": "p_1473", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_1474", "content": "ACh [SEP] alysis to measure basal and potassium-stimulated acetylcholine (ACh) release in the CA1 region of the hippocampus. Potassium was ap", "tokenized_content": [2, 3546, 3, 1969, 4662, 1942, 2931, 5342, 1930, 9057, 17, 5449, 14561, 12, 3546, 13, 4012, 1922, 1920, 12961, 3031, 1927, 1920, 7661, 18, 9057, 1982, 2100, 3]}, "items": [{"id": "p_1474", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_1475", "content": "Potassium [SEP] etylcholine (ACh) release in the CA1 region of the hippocampus. Potassium was applied by reverse dialysis twice, separated by 75 min. Hip", "tokenized_content": [2, 9057, 3, 2140, 2199, 11603, 12, 3546, 13, 4012, 1922, 1920, 12961, 3031, 1927, 1920, 7661, 18, 9057, 1982, 3730, 2007, 5267, 9787, 6470, 16, 6239, 2007, 4089, 2360, 18, 3]}, "items": [{"id": "p_1475", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1476", "content": "convulsions [SEP] ampal ACh also was measured during testing for handling-induced convulsions. RESULTS: Sensitivity to several convulsion endpoints induced b", "tokenized_content": [2, 4772, 19389, 3, 16983, 1024, 3546, 2222, 1982, 3045, 2409, 4213, 1958, 12361, 17, 2719, 4772, 19389, 18, 2274, 30, 3802, 1942, 2980, 4772, 12138, 13613, 2719, 44, 3]}, "items": [{"id": "p_1476", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1477", "content": "convulsion [SEP] ampal ACh also was measured during testing for handling-induced convulsions. RESULTS: Sensitivity to several convulsion endpoints induced ", "tokenized_content": [2, 4772, 12138, 3, 16983, 1024, 3546, 2222, 1982, 3045, 2409, 4213, 1958, 12361, 17, 2719, 4772, 19389, 18, 2274, 30, 3802, 1942, 2980, 4772, 12138, 13613, 2719, 3]}, "items": [{"id": "p_1477", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1478", "content": "KCl [SEP] ts, the lines did not differ in basal release of ACh, and 50 mM KCl increased ACh output in both lines of mice. However, the increa", "tokenized_content": [2, 10386, 3, 4894, 16, 1920, 3557, 2811, 2084, 2129, 1922, 5342, 4012, 1927, 3546, 16, 1930, 2761, 2489, 10386, 2502, 3546, 6647, 1922, 2321, 3557, 1927, 2518, 18, 2406, 16, 3]}, "items": [{"id": "p_1478", "content": "KCL compound [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10386, 3547, 3, 3]}]}
{"query": {"id": "q_1479", "content": "convulsants [SEP] holinergic activity and postsynaptic sensitivity to cholinergic convulsants may be associated with ethanol withdrawal severity and implicat", "tokenized_content": [2, 4772, 6325, 2356, 3, 8001, 12745, 2455, 1930, 13090, 3802, 1942, 13908, 4772, 6325, 2356, 2278, 1998, 2458, 1956, 5757, 9594, 5155, 1930, 6313, 6102, 1031, 3]}, "items": [{"id": "p_1479", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1480", "content": "dexamethasone [SEP] Prenatal dexamethasone programs hypertension and renal injury in the rat.", "tokenized_content": [2, 12681, 3, 10907, 12681, 6144, 5579, 1930, 4604, 4047, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_1480", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_1481", "content": "hypertension [SEP] Prenatal dexamethasone programs hypertension and renal injury in the rat.", "tokenized_content": [2, 5579, 3, 10907, 12681, 6144, 5579, 1930, 4604, 4047, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_1481", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1482", "content": "renal injury [SEP] Prenatal dexamethasone programs hypertension and renal injury in the rat.", "tokenized_content": [2, 4604, 4047, 3, 10907, 12681, 6144, 5579, 1930, 4604, 4047, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_1482", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1483", "content": "dexamethasone [SEP] . The purpose of the present study was to determine if prenatal dexamethasone programmed a progressive increase in blood pressure and renal i", "tokenized_content": [2, 12681, 3, 18, 1920, 5120, 1927, 1920, 2481, 2161, 1982, 1942, 3415, 2647, 10907, 12681, 13839, 43, 7529, 2760, 1922, 2877, 3772, 1930, 4604, 51, 3]}, "items": [{"id": "p_1483", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_1484", "content": "increase in blood pressure [SEP] to determine if prenatal dexamethasone programmed a progressive increase in blood pressure and renal injury in rats. Pregnant rats were given either vehic", "tokenized_content": [2, 2760, 1922, 2877, 3772, 3, 1942, 3415, 2647, 10907, 12681, 13839, 43, 7529, 2760, 1922, 2877, 3772, 1930, 4604, 4047, 1922, 3615, 18, 7808, 3615, 1985, 3258, 3108, 5959, 1935, 3]}, "items": [{"id": "p_1484", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1485", "content": "renal injury [SEP] thasone programmed a progressive increase in blood pressure and renal injury in rats. Pregnant rats were given either vehicle or 2 daily int", "tokenized_content": [2, 4604, 4047, 3, 21513, 5810, 1021, 13839, 43, 7529, 2760, 1922, 2877, 3772, 1930, 4604, 4047, 1922, 3615, 18, 7808, 3615, 1985, 3258, 3108, 6463, 2014, 22, 4692, 2218, 3]}, "items": [{"id": "p_1485", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1486", "content": "reduction in glomerular number [SEP] dministered dexamethasone on days 15 and 16 gestation had a 20% reduction in glomerular number compared with control at 6 to 9 months of age (22 527+/-509 ver", "tokenized_content": [2, 3378, 1922, 11655, 2529, 3, 3931, 15472, 3188, 12681, 1990, 3000, 2461, 1930, 2641, 10879, 2430, 43, 2036, 9, 3378, 1922, 11655, 2529, 2452, 1956, 2285, 2019, 26, 1942, 29, 3]}, "items": [{"id": "p_1486", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1487", "content": "elevated blood pressures [SEP] ne on days 15 and 16, 17 and 18, and 13 and 14 of gestation had elevated blood pressures at 6 months of age; the latter group did not have a reduction i", "tokenized_content": [2, 4664, 2877, 11704, 3, 2069, 1990, 3000, 2461, 1930, 2641, 16, 2752, 1930, 2654, 16, 1930, 2590, 1930, 2607, 1927, 10879, 2430, 4664, 2877, 11704, 2019, 26, 3221, 1927, 2632, 3]}, "items": [{"id": "p_1487", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1488", "content": "glomerulosclerosis [SEP] ethasone on days 15 and 16 of gestation had more glomeruli with glomerulosclerosis than control rats. This study shows that prenatal dexamethasone", "tokenized_content": [2, 19268, 25081, 3, 3293, 11718, 1990, 3000, 2461, 1930, 2641, 1927, 10879, 2430, 2253, 20276, 1956, 19268, 25081, 2254, 2285, 3615, 18, 2052, 2161, 3661, 1988, 10907, 12681, 3]}, "items": [{"id": "p_1488", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_1489", "content": "hypertension [SEP] ts in a reduction in glomerular number, glomerulosclerosis, and hypertension when administered at specific points during gestation. Hyperten", "tokenized_content": [2, 5579, 3, 4894, 1922, 43, 3378, 1922, 11655, 2529, 16, 19268, 25081, 16, 1930, 5579, 2469, 5254, 2019, 2487, 4273, 2409, 10879, 18, 4506, 1917, 3]}, "items": [{"id": "p_1489", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1490", "content": "Hypertension [SEP] rtension when administered at specific points during gestation. Hypertension was observed in animals that had a reduction in glomeruli as we", "tokenized_content": [2, 5579, 3, 4341, 3212, 2469, 5254, 2019, 2487, 4273, 2409, 10879, 18, 5579, 1982, 2528, 1922, 3555, 1988, 2430, 43, 3378, 1922, 20276, 1966, 2038, 3]}, "items": [{"id": "p_1490", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1491", "content": "venous thromboembolism [SEP] The risk of venous thromboembolism in women prescribed cyproterone acetate in combination with eth", "tokenized_content": [2, 8562, 23821, 3, 1920, 2565, 1927, 8562, 23821, 1922, 3089, 9975, 6120, 23362, 2290, 7959, 1922, 3921, 1956, 3293, 3]}, "items": [{"id": "p_1491", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1492", "content": "cyproterone acetate [SEP] The risk of venous thromboembolism in women prescribed cyproterone acetate in combination with ethinyl estradiol: a nested cohort analysis", "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 1920, 2565, 1927, 8562, 23821, 1922, 3089, 9975, 6120, 23362, 2290, 7959, 1922, 3921, 1956, 17180, 16323, 1024, 11513, 30, 43, 13735, 4382, 2333, 3]}, "items": [{"id": "p_1492", "content": "Cyproterone Acetate [SEP] An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen rec", "score": 1, "type": null, "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 1925, 5899, 1956, 2246, 17, 10817, 1930, 10759, 4926, 1923, 3879, 18, 2176, 3661, 10362, 2743, 1956, 11842, 17188, 7983, 2019, 10817, 2090, 3]}]}
{"query": {"id": "q_1493", "content": "ethinyl estradiol [SEP] ism in women prescribed cyproterone acetate in combination with ethinyl estradiol: a nested cohort analysis and case-control study.", "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 1977, 1035, 1922, 3089, 9975, 6120, 23362, 2290, 7959, 1922, 3921, 1956, 17180, 16323, 1024, 11513, 30, 43, 13735, 4382, 2333, 1930, 3087, 17, 2285, 3]}, "items": [{"id": "p_1493", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_1494", "content": "Cyproterone acetate [SEP] BACKGROUND: Cyproterone acetate combined with ethinyl estradiol (CPA/EE) is licensed in the UK ", "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 3872, 30, 6120, 23362, 2290, 7959, 4252, 1956, 17180, 16323, 1024, 11513, 12, 22675, 19, 11150, 13, 1977, 20969, 1922, 1920, 5999, 3]}, "items": [{"id": "p_1494", "content": "Cyproterone Acetate [SEP] An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen rec", "score": 1, "type": null, "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 1925, 5899, 1956, 2246, 17, 10817, 1930, 10759, 4926, 1923, 3879, 18, 2176, 3661, 10362, 2743, 1956, 11842, 17188, 7983, 2019, 10817, 2090, 3]}]}
{"query": {"id": "q_1495", "content": "ethinyl estradiol [SEP] BACKGROUND: Cyproterone acetate combined with ethinyl estradiol (CPA/EE) is licensed in the UK for the treatment of women with ", "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 3872, 30, 6120, 23362, 2290, 7959, 4252, 1956, 17180, 16323, 1024, 11513, 12, 22675, 19, 11150, 13, 1977, 20969, 1922, 1920, 5999, 1958, 1920, 2311, 3]}, "items": [{"id": "p_1495", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_1496", "content": "CPA [SEP] ACKGROUND: Cyproterone acetate combined with ethinyl estradiol (CPA/EE) is licensed in the UK for the treatment of women with acne ", "tokenized_content": [2, 22675, 3, 2000, 23254, 3049, 30, 6120, 23362, 2290, 7959, 4252, 1956, 17180, 16323, 1024, 11513, 12, 22675, 19, 11150, 13, 1977, 20969, 1922, 1920, 5999, 1958, 1920, 2311, 1927, 3]}, "items": [{"id": "p_1496", "content": "Cyproterone Acetate [SEP] An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen rec", "score": 1, "type": null, "tokenized_content": [2, 6120, 23362, 2290, 7959, 3, 1925, 5899, 1956, 2246, 17, 10817, 1930, 10759, 4926, 1923, 3879, 18, 2176, 3661, 10362, 2743, 1956, 11842, 17188, 7983, 2019, 10817, 2090, 3]}]}
{"query": {"id": "q_1497", "content": "EE [SEP] ROUND: Cyproterone acetate combined with ethinyl estradiol (CPA/EE) is licensed in the UK for the treatment of women with acne and", "tokenized_content": [2, 11150, 3, 7464, 30, 6120, 23362, 2290, 7959, 4252, 1956, 17180, 16323, 1024, 11513, 12, 22675, 19, 11150, 13, 1977, 20969, 1922, 1920, 5999, 1958, 1920, 2311, 1927, 3089, 1956, 3]}, "items": [{"id": "p_1497", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_1498", "content": "acne [SEP]  (CPA/EE) is licensed in the UK for the treatment of women with acne and hirsutism and is also a treatment option for polycystic ova", "tokenized_content": [2, 25403, 3, 12, 22675, 19, 11150, 13, 1977, 20969, 1922, 1920, 5999, 1958, 1920, 2311, 1927, 3089, 1956, 25403, 1930, 15086, 20490, 3600, 1035, 1930, 1977, 2222, 43, 2311, 8297, 3]}, "items": [{"id": "p_1498", "content": "Acne Vulgaris [SEP] A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open co", "score": 1, "type": null, "tokenized_content": [2, 25403, 22621, 3, 43, 3724, 4770, 1927, 1920, 7547, 2217, 7972, 1972, 2080, 11161, 2458, 1956, 1925, 2760, 1922, 20106, 1989, 5512, 18, 2176, 1977, 4378, 2007, 4437, 2081, 3]}]}
{"query": {"id": "q_1499", "content": "hirsutism [SEP]  is licensed in the UK for the treatment of women with acne and hirsutism and is also a treatment option for polycystic ovary syndrome (P", "tokenized_content": [2, 15086, 20490, 3600, 1035, 3, 1977, 20969, 1922, 1920, 5999, 1958, 1920, 2311, 1927, 3089, 1956, 25403, 1930, 15086, 20490, 3600, 1035, 1930, 1977, 2222, 43, 2311, 8297, 1958, 26316, 3]}, "items": [{"id": "p_1499", "content": "Hirsutism [SEP] A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as ", "score": 1, "type": null, "tokenized_content": [2, 15086, 20490, 3600, 1035, 3, 43, 2625, 2528, 1922, 3089, 1930, 3069, 2469, 2276, 1977, 5799, 18372, 3362, 7018, 1927, 1925, 4160, 4005, 3282, 3114, 16, 2427, 1966, 3]}]}
{"query": {"id": "q_1500", "content": "polycystic ovary syndrome [SEP] omen with acne and hirsutism and is also a treatment option for polycystic ovary syndrome (PCOS). Previous studies have demonstrated an increased risk of", "tokenized_content": [2, 26316, 13464, 4741, 3, 12453, 1022, 1956, 25403, 1930, 15086, 20490, 3600, 1035, 1930, 1977, 2222, 43, 2311, 8297, 1958, 26316, 13464, 4741, 12, 16506, 13, 18, 2555, 2351, 2162, 3]}, "items": [{"id": "p_1500", "content": "Polycystic Ovary Syndrome [SEP] A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; ", "score": 1, "type": null, "tokenized_content": [2, 26316, 13464, 4741, 3, 43, 2796, 4770, 4378, 2007, 15446, 16, 15086, 20490, 3600, 1035, 31, 5379, 31, 1930, 3425, 15994, 12654, 2427, 1966, 15039, 19047, 21588, 31, 3]}]}
{"query": {"id": "q_1501", "content": "PCOS [SEP] m and is also a treatment option for polycystic ovary syndrome (PCOS). Previous studies have demonstrated an increased risk of venou", "tokenized_content": [2, 16506, 3, 55, 1930, 1977, 2222, 43, 2311, 8297, 1958, 26316, 13464, 4741, 12, 16506, 13, 18, 2555, 2351, 2162, 3161, 1925, 2502, 2565, 1927, 8102, 4468, 3]}, "items": [{"id": "p_1501", "content": "Polycystic Ovary Syndrome [SEP] A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; ", "score": 1, "type": null, "tokenized_content": [2, 26316, 13464, 4741, 3, 43, 2796, 4770, 4378, 2007, 15446, 16, 15086, 20490, 3600, 1035, 31, 5379, 31, 1930, 3425, 15994, 12654, 2427, 1966, 15039, 19047, 21588, 31, 3]}]}
{"query": {"id": "q_1502", "content": "venous thromboembolism [SEP] (PCOS). Previous studies have demonstrated an increased risk of venous thromboembolism (VTE) associated with CPA/EE compared with conventional combine", "tokenized_content": [2, 8562, 23821, 3, 12, 16506, 13, 18, 2555, 2351, 2162, 3161, 1925, 2502, 2565, 1927, 8562, 23821, 12, 16931, 13, 2458, 1956, 22675, 19, 11150, 2452, 1956, 5552, 14003, 3]}, "items": [{"id": "p_1502", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1503", "content": "VTE [SEP]  have demonstrated an increased risk of venous thromboembolism (VTE) associated with CPA/EE compared with conventional combined ora", "tokenized_content": [2, 16931, 3, 2162, 3161, 1925, 2502, 2565, 1927, 8562, 23821, 12, 16931, 13, 2458, 1956, 22675, 19, 11150, 2452, 1956, 5552, 4252, 2014, 1019, 3]}, "items": [{"id": "p_1503", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1504", "content": "oral contraceptives [SEP] VTE) associated with CPA/EE compared with conventional combined oral contraceptives (COCs). We believe the results of those studies may have been a", "tokenized_content": [2, 4726, 25434, 3, 16931, 13, 2458, 1956, 22675, 19, 11150, 2452, 1956, 5552, 4252, 4726, 25434, 12, 6880, 1036, 13, 18, 2038, 9129, 1920, 2274, 1927, 2690, 2351, 2278, 2162, 3]}, "items": [{"id": "p_1504", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_1505", "content": "Pseudoacromegaly [SEP] Pseudoacromegaly induced by the long-term use of minoxidil.", "tokenized_content": [2, 11520, 6312, 19323, 3, 11520, 6312, 19323, 2719, 2007, 1920, 2815, 17, 2576, 2485, 1927, 2360, 4811, 1970, 18, 3]}, "items": [{"id": "p_1505", "content": "Disease [SEP] A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts,", "score": 1, "type": null, "tokenized_content": [2, 2573, 3, 43, 15876, 11896, 2585, 1956, 43, 6293, 2735, 1927, 6879, 1930, 3601, 18, 2176, 2278, 4081, 1920, 4292, 3362, 2014, 2967, 1927, 2496, 7516, 16, 3]}]}
{"query": {"id": "q_1506", "content": "minoxidil [SEP] Pseudoacromegaly induced by the long-term use of minoxidil.", "tokenized_content": [2, 2360, 4811, 1970, 3, 11520, 6312, 19323, 2719, 2007, 1920, 2815, 17, 2576, 2485, 1927, 2360, 4811, 1970, 18, 3]}, "items": [{"id": "p_1506", "content": "Minoxidil [SEP] A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLO", "score": 1, "type": null, "tokenized_content": [2, 2360, 4811, 1970, 3, 43, 6828, 3083, 17, 8290, 5009, 28194, 12, 28194, 4820, 13, 1988, 7268, 5009, 3554, 1930, 9300, 43, 6462, 1922, 16635, 3]}]}
{"query": {"id": "q_1507", "content": "Acromegaly [SEP] Acromegaly is an endocrine disorder caused by chronic excessive growth hor", "tokenized_content": [2, 10428, 19323, 3, 10428, 19323, 1977, 1925, 10749, 4770, 4189, 2007, 3724, 9122, 2905, 7114, 3]}, "items": [{"id": "p_1507", "content": "Acromegaly [SEP] A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of", "score": 1, "type": null, "tokenized_content": [2, 10428, 19323, 3, 43, 2625, 4189, 2007, 7171, 3395, 1942, 9122, 2616, 2905, 6365, 1922, 4440, 18, 2176, 1977, 4378, 2007, 18525, 16363, 1927, 3]}]}
{"query": {"id": "q_1508", "content": "endocrine disorder [SEP] Acromegaly is an endocrine disorder caused by chronic excessive growth hormone secretion from the a", "tokenized_content": [2, 10749, 4770, 3, 10428, 19323, 1977, 1925, 10749, 4770, 4189, 2007, 3724, 9122, 2905, 6365, 5512, 2037, 1920, 43, 3]}, "items": [{"id": "p_1508", "content": "Endocrine System Diseases [SEP] Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10749, 2433, 3902, 3, 6598, 4028, 1927, 1920, 10749, 11186, 16, 1930, 3902, 3864, 2037, 4552, 2237, 1927, 3322, 10224, 18, 3]}]}
{"query": {"id": "q_1509", "content": "hypertrophy [SEP] g changes occur as a result of bone, cartilage, and soft tissue hypertrophy, including the thickening of the skin, coarsening of facial fea", "tokenized_content": [2, 11014, 3, 49, 2840, 4704, 1966, 43, 3211, 1927, 3622, 16, 8642, 16, 1930, 3793, 2960, 11014, 16, 2710, 1920, 16121, 1927, 1920, 4407, 16, 18372, 2989, 1927, 9567, 2650, 3]}, "items": [{"id": "p_1509", "content": "Hypertrophy [SEP] General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor ", "score": 1, "type": null, "tokenized_content": [2, 11014, 3, 3335, 2760, 1922, 9390, 1927, 43, 3131, 2014, 3090, 2810, 1942, 2024, 16363, 1930, 4858, 1927, 13315, 1930, 21417, 16, 2084, 2810, 1942, 2798, 3]}]}
{"query": {"id": "q_1510", "content": "cutis verticis gyrata [SEP]  the thickening of the skin, coarsening of facial features, and cutis verticis gyrata. Pseudoacromegaly, on the other hand, is the presence of simila", "tokenized_content": [2, 4665, 1937, 3566, 2002, 1937, 9430, 5499, 3, 1920, 16121, 1927, 1920, 4407, 16, 18372, 2989, 1927, 9567, 4075, 16, 1930, 4665, 1937, 3566, 2002, 1937, 9430, 5499, 18, 11520, 3]}, "items": [{"id": "p_1510", "content": "Akesson syndrome [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4464, 1979, 1916, 4741, 3, 3]}]}
{"query": {"id": "q_1511", "content": "Pseudoacromegaly [SEP] skin, coarsening of facial features, and cutis verticis gyrata. Pseudoacromegaly, on the other hand, is the presence of similar acromegaloid fea", "tokenized_content": [2, 11520, 6312, 19323, 3, 4407, 16, 18372, 2989, 1927, 9567, 4075, 16, 1930, 4665, 1937, 3566, 2002, 1937, 9430, 5499, 18, 11520, 6312, 19323, 16, 1990, 1920, 2303, 3897, 16, 3]}, "items": [{"id": "p_1511", "content": "Disease [SEP] A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts,", "score": 1, "type": null, "tokenized_content": [2, 2573, 3, 43, 15876, 11896, 2585, 1956, 43, 6293, 2735, 1927, 6879, 1930, 3601, 18, 2176, 2278, 4081, 1920, 4292, 3362, 2014, 2967, 1927, 2496, 7516, 16, 3]}]}
{"query": {"id": "q_1512", "content": "pseudoacromegaly [SEP] or insulin-like growth factor levels. We present a patient with pseudoacromegaly that resulted from the long-term use of minoxidil at an unusual", "tokenized_content": [2, 11520, 6312, 19323, 3, 2014, 4122, 17, 3189, 2905, 2991, 2428, 18, 2038, 2481, 43, 2774, 1956, 11520, 6312, 19323, 1988, 4306, 2037, 1920, 2815, 17, 2576, 2485, 1927, 2360, 3]}, "items": [{"id": "p_1512", "content": "Disease [SEP] A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts,", "score": 1, "type": null, "tokenized_content": [2, 2573, 3, 43, 15876, 11896, 2585, 1956, 43, 6293, 2735, 1927, 6879, 1930, 3601, 18, 2176, 2278, 4081, 1920, 4292, 3362, 2014, 2967, 1927, 2496, 7516, 16, 3]}]}
{"query": {"id": "q_1513", "content": "minoxidil [SEP] t with pseudoacromegaly that resulted from the long-term use of minoxidil at an unusually high dose. This is the first case report of pse", "tokenized_content": [2, 2360, 4811, 1970, 3, 62, 1956, 11520, 6312, 19323, 1988, 4306, 2037, 1920, 2815, 17, 2576, 2485, 1927, 2360, 4811, 1970, 2019, 1925, 25041, 2149, 3253, 18, 2052, 1977, 1920, 3]}, "items": [{"id": "p_1513", "content": "Minoxidil [SEP] A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLO", "score": 1, "type": null, "tokenized_content": [2, 2360, 4811, 1970, 3, 43, 6828, 3083, 17, 8290, 5009, 28194, 12, 28194, 4820, 13, 1988, 7268, 5009, 3554, 1930, 9300, 43, 6462, 1922, 16635, 3]}]}
{"query": {"id": "q_1514", "content": "anemia [SEP] Combined androgen blockade-induced anemia in prostate cancer patients without bone involvement.", "tokenized_content": [2, 10679, 3, 4252, 10817, 9847, 17, 2719, 10679, 1922, 5683, 2539, 2132, 2979, 3622, 5668, 18, 3]}, "items": [{"id": "p_1514", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_1515", "content": "prostate cancer [SEP] Combined androgen blockade-induced anemia in prostate cancer patients without bone involvement.", "tokenized_content": [2, 5683, 2539, 3, 4252, 10817, 9847, 17, 2719, 10679, 1922, 5683, 2539, 2132, 2979, 3622, 5668, 18, 3]}, "items": [{"id": "p_1515", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_1516", "content": "anemia [SEP] he onset and extent of combined androgen blockade (CAB)-induced anemia in prostate cancer patients without bone involvement. PATIENTS ", "tokenized_content": [2, 10679, 3, 2234, 4727, 1930, 5064, 1927, 4252, 10817, 9847, 12, 11026, 13, 17, 2719, 10679, 1922, 5683, 2539, 2132, 2979, 3622, 5668, 18, 2132, 3]}, "items": [{"id": "p_1516", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_1517", "content": "prostate cancer [SEP] nd extent of combined androgen blockade (CAB)-induced anemia in prostate cancer patients without bone involvement. PATIENTS AND METHODS: Forty-", "tokenized_content": [2, 5683, 2539, 3, 8026, 5064, 1927, 4252, 10817, 9847, 12, 11026, 13, 17, 2719, 10679, 1922, 5683, 2539, 2132, 2979, 3622, 5668, 18, 2132, 1930, 2860, 30, 11270, 17, 3]}, "items": [{"id": "p_1517", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_1518", "content": "prostatic adenocarcinoma [SEP] nt. PATIENTS AND METHODS: Forty-two patients with biopsy-proven prostatic adenocarcinoma [26 with stage C (T3N0M0) and 16 with stage D1 (T3N1M0)] were i", "tokenized_content": [2, 17879, 9573, 3, 5891, 18, 2132, 1930, 2860, 30, 11270, 17, 2288, 2132, 1956, 6831, 17, 9253, 17879, 9573, 37, 3179, 1956, 3587, 45, 12, 9627, 1022, 1008, 1035, 1008, 3]}, "items": [{"id": "p_1518", "content": "Adenocarcinoma [SEP] A malignant epithelial tumor with a glandular organization.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9573, 3, 43, 6558, 4944, 2798, 1956, 43, 21808, 5901, 18, 3]}]}
{"query": {"id": "q_1519", "content": "leuprolide acetate [SEP] 3N1M0)] were included in this study. All patients received CAB [leuprolide acetate (LHRH-A) 3.75 mg, intramuscularly, every 28 days plus 250 mg fl", "tokenized_content": [2, 25290, 2226, 2261, 7959, 3, 23, 7301, 1035, 1008, 13, 39, 1985, 3063, 1922, 2052, 2161, 18, 2136, 2132, 4004, 11026, 37, 25290, 2226, 2261, 7959, 12, 9107, 5004, 17, 3]}, "items": [{"id": "p_1519", "content": "Leuprolide [SEP] A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary g", "score": 1, "type": null, "tokenized_content": [2, 25290, 2226, 2261, 3, 43, 6828, 6830, 2815, 17, 8290, 7829, 1927, 21704, 17, 13182, 6365, 1988, 7014, 1920, 4271, 1930, 4012, 1927, 10621, 49, 3]}]}
{"query": {"id": "q_1520", "content": "LHRH-A [SEP] d in this study. All patients received CAB [leuprolide acetate (LHRH-A) 3.75 mg, intramuscularly, every 28 days plus 250 mg flutamide,", "tokenized_content": [2, 9107, 5004, 17, 43, 3, 46, 1922, 2052, 2161, 18, 2136, 2132, 4004, 11026, 37, 25290, 2226, 2261, 7959, 12, 9107, 5004, 17, 43, 13, 23, 18, 4089, 2786, 16, 3]}, "items": [{"id": "p_1520", "content": "Leuprolide [SEP] A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary g", "score": 1, "type": null, "tokenized_content": [2, 25290, 2226, 2261, 3, 43, 6828, 6830, 2815, 17, 8290, 7829, 1927, 21704, 17, 13182, 6365, 1988, 7014, 1920, 4271, 1930, 4012, 1927, 10621, 49, 3]}]}
{"query": {"id": "q_1521", "content": "flutamide [SEP] te (LHRH-A) 3.75 mg, intramuscularly, every 28 days plus 250 mg flutamide, tid, per Os] and were evaluated for anemia by physical examina", "tokenized_content": [2, 2848, 3857, 16408, 1021, 3, 3602, 12, 9107, 5004, 17, 43, 13, 23, 18, 4089, 2786, 16, 16774, 1954, 16, 4808, 3158, 3000, 5390, 6330, 2786, 2848, 3857, 16408, 1021, 3]}, "items": [{"id": "p_1521", "content": "Flutamide [SEP] An antiandrogen with about the same potency as cyproterone in rodent and canine species.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 3857, 16408, 1021, 3, 1925, 2246, 2153, 4758, 1956, 3001, 1920, 2841, 10397, 1966, 6120, 23362, 2290, 1922, 11880, 1930, 13617, 3038, 18, 3]}]}
{"query": {"id": "q_1522", "content": "Testosterone [SEP] bsequent intervals (1, 2, 3 and 6 months post-CAB). Hb, PSA and Testosterone measurements were recorded. Patients with stage D2-3 disease, a", "tokenized_content": [2, 10592, 3, 30277, 5089, 4905, 6087, 12, 21, 16, 22, 16, 23, 1930, 26, 3221, 2753, 17, 11026, 13, 18, 4873, 16, 10203, 1930, 10592, 4146, 1985, 4562, 18, 2132, 3]}, "items": [{"id": "p_1522", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_1523", "content": "dilated cardiomyopathy [SEP] Reversible dilated cardiomyopathy related to amphotericin B therapy.", "tokenized_content": [2, 16434, 14141, 3, 10743, 16434, 14141, 2712, 1942, 23210, 44, 3181, 18, 3]}, "items": [{"id": "p_1523", "content": "Cardiomyopathy, Dilated [SEP] A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 16434, 3, 43, 2386, 1927, 4435, 3760, 2573, 1988, 1977, 4378, 2007, 6493, 16470, 16, 6493, 5273, 16, 1930, 4003, 4574, 18, 2565, 3]}]}
{"query": {"id": "q_1524", "content": "amphotericin B [SEP] Reversible dilated cardiomyopathy related to amphotericin B therapy.", "tokenized_content": [2, 23210, 44, 3, 10743, 16434, 14141, 2712, 1942, 23210, 44, 3181, 18, 3]}, "items": [{"id": "p_1524", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_1525", "content": "dilated cardiomyopathy [SEP] We describe a patient who developed dilated cardiomyopathy and clinical congestive heart failure after 2 months of therapy", "tokenized_content": [2, 16434, 14141, 3, 2038, 5993, 43, 2774, 2746, 3530, 16434, 14141, 1930, 2535, 20180, 4003, 4574, 2256, 22, 3221, 1927, 3181, 3]}, "items": [{"id": "p_1525", "content": "Cardiomyopathy, Dilated [SEP] A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 16434, 3, 43, 2386, 1927, 4435, 3760, 2573, 1988, 1977, 4378, 2007, 6493, 16470, 16, 6493, 5273, 16, 1930, 4003, 4574, 18, 2565, 3]}]}
{"query": {"id": "q_1526", "content": "heart failure [SEP] nt who developed dilated cardiomyopathy and clinical congestive heart failure after 2 months of therapy with amphotericin B (AmB) for dissemi", "tokenized_content": [2, 4003, 4574, 3, 5891, 2746, 3530, 16434, 14141, 1930, 2535, 20180, 4003, 4574, 2256, 22, 3221, 1927, 3181, 1956, 23210, 44, 12, 6168, 13, 1958, 10166, 1033, 3]}, "items": [{"id": "p_1526", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_1527", "content": "amphotericin B [SEP] linical congestive heart failure after 2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographi", "tokenized_content": [2, 23210, 44, 3, 8128, 2046, 20180, 4003, 4574, 2256, 22, 3221, 1927, 3181, 1956, 23210, 44, 12, 6168, 13, 1958, 17593, 28014, 13756, 2642, 13386, 2475, 18, 4167, 9877, 2893, 3]}, "items": [{"id": "p_1527", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_1528", "content": "AmB [SEP] ve heart failure after 2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographic abn", "tokenized_content": [2, 6168, 3, 3428, 4003, 4574, 2256, 22, 3221, 1927, 3181, 1956, 23210, 44, 12, 6168, 13, 1958, 17593, 28014, 13756, 2642, 13386, 2475, 18, 4167, 18700, 4456, 3]}, "items": [{"id": "p_1528", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_1529", "content": "coccidioidomycosis [SEP]  2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographic abnormalities and heart failure resolved", "tokenized_content": [2, 28014, 13756, 2642, 13386, 2475, 3, 22, 3221, 1927, 3181, 1956, 23210, 44, 12, 6168, 13, 1958, 17593, 28014, 13756, 2642, 13386, 2475, 18, 4167, 18700, 6754, 1930, 4003, 4574, 3]}, "items": [{"id": "p_1529", "content": "Coccidioidomycosis [SEP] Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley feve", "score": 1, "type": null, "tokenized_content": [2, 28014, 13756, 2642, 13386, 2475, 3, 2909, 1956, 43, 16461, 1927, 1920, 9487, 28014, 13756, 12363, 16, 12310, 1942, 1920, 28837, 6128, 4376, 18, 2176, 1977, 8929, 6043, 19469, 2650, 1961, 3]}]}
{"query": {"id": "q_1530", "content": "posaconazole [SEP] chocardiographic abnormalities and heart failure resolved after posaconazole was substituted for AmB. It is important to recognize the rare ", "tokenized_content": [2, 2159, 27669, 3, 4551, 15339, 7408, 4158, 6754, 1930, 4003, 4574, 8397, 2256, 2159, 27669, 1982, 11798, 1958, 6168, 18, 2176, 1977, 2715, 1942, 9967, 1920, 5844, 3]}, "items": [{"id": "p_1530", "content": "posaconazole [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2159, 27669, 3, 3]}]}
{"query": {"id": "q_1531", "content": "toxicity [SEP] t is important to recognize the rare and potentially reversible toxicity of AmB.", "tokenized_content": [2, 5532, 3, 62, 1977, 2715, 1942, 9967, 1920, 5844, 1930, 5063, 10743, 5532, 1927, 6168, 18, 3]}, "items": [{"id": "p_1531", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1532", "content": "quinine [SEP] Risks of the consumption of beverages containing quinine.", "tokenized_content": [2, 9012, 2053, 3, 7481, 1927, 1920, 5434, 1927, 19860, 3165, 9012, 2053, 18, 3]}, "items": [{"id": "p_1532", "content": "Quinine [SEP] An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extr", "score": 1, "type": null, "tokenized_content": [2, 9012, 2053, 3, 1925, 29951, 3595, 2037, 1920, 18399, 1927, 1920, 10510, 28226, 2175, 6694, 18, 2176, 1977, 2251, 1966, 1925, 27290, 2838, 16, 1930, 1977, 1920, 3500, 24364, 1922, 2821, 3]}]}
{"query": {"id": "q_1533", "content": "nocturnal leg cramps [SEP] e United States Food and Drug Administration banned its use for nocturnal leg cramps due to lack of safety and efficacy, quinine is widely available", "tokenized_content": [2, 18975, 6703, 24422, 6588, 1036, 3, 47, 6128, 4376, 3959, 1930, 2838, 4183, 15114, 5300, 2496, 2485, 1958, 18975, 6703, 24422, 6588, 1036, 2810, 1942, 3630, 1927, 5407, 1930, 4348, 3]}, "items": [{"id": "p_1533", "content": "Sleep-Wake Transition Disorders [SEP] Parasomnias characterized by behavioral abnormalities that occur during the transition between wakefulness and sleep (or between", "score": 1, "type": null, "tokenized_content": [2, 5006, 17, 14763, 4832, 4414, 3, 5336, 16393, 1036, 4378, 2007, 5343, 6754, 1988, 4704, 2409, 1920, 4832, 2192, 27866, 1930, 5006, 12, 2014, 2192, 3]}]}
{"query": {"id": "q_1534", "content": "quinine [SEP] se for nocturnal leg cramps due to lack of safety and efficacy, quinine is widely available in beverages including tonic water and bitt", "tokenized_content": [2, 9012, 2053, 3, 2058, 1958, 18975, 6703, 24422, 6588, 1036, 2810, 1942, 3630, 1927, 5407, 1930, 4348, 16, 9012, 2053, 1977, 5673, 3322, 1922, 19860, 2710, 16887, 3224, 1930, 11996, 3]}, "items": [{"id": "p_1534", "content": "Quinine [SEP] An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extr", "score": 1, "type": null, "tokenized_content": [2, 9012, 2053, 3, 1925, 29951, 3595, 2037, 1920, 18399, 1927, 1920, 10510, 28226, 2175, 6694, 18, 2176, 1977, 2251, 1966, 1925, 27290, 2838, 16, 1930, 1977, 1920, 3500, 24364, 1922, 2821, 3]}]}
{"query": {"id": "q_1535", "content": "neurological complications [SEP] al reports suggest that products containing quinine may produce neurological complications, including confusion, altered mental status, seizures, and coma", "tokenized_content": [2, 7605, 5021, 3, 1969, 4710, 3220, 1988, 4461, 3165, 9012, 2053, 2278, 5074, 7605, 5021, 16, 2710, 18272, 16, 5520, 5018, 3642, 16, 10060, 16, 1930, 22337, 3]}, "items": [{"id": "p_1535", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_1536", "content": "confusion [SEP] ining quinine may produce neurological complications, including confusion, altered mental status, seizures, and coma, particularly in old", "tokenized_content": [2, 18272, 3, 1922, 1941, 9012, 2053, 2278, 5074, 7605, 5021, 16, 2710, 18272, 16, 5520, 5018, 3642, 16, 10060, 16, 1930, 22337, 16, 4443, 1922, 4156, 3]}, "items": [{"id": "p_1536", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_1537", "content": "seizures [SEP] ical complications, including confusion, altered mental status, seizures, and coma, particularly in older women. Psychologists need to i", "tokenized_content": [2, 10060, 3, 14784, 1024, 5021, 16, 2710, 18272, 16, 5520, 5018, 3642, 16, 10060, 16, 1930, 22337, 16, 4443, 1922, 4706, 3089, 18, 28295, 2942, 1942, 51, 3]}, "items": [{"id": "p_1537", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1538", "content": "coma [SEP] ions, including confusion, altered mental status, seizures, and coma, particularly in older women. Psychologists need to inquire abo", "tokenized_content": [2, 22337, 3, 6982, 16, 2710, 18272, 16, 5520, 5018, 3642, 16, 10060, 16, 1930, 22337, 16, 4443, 1922, 4706, 3089, 18, 28295, 2942, 1942, 20253, 2952, 28659, 3]}, "items": [{"id": "p_1538", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_1539", "content": "Organophosphate [SEP] Organophosphate-induced convulsions and prevention of neuropathological damages", "tokenized_content": [2, 3090, 15707, 3, 3090, 15707, 17, 2719, 4772, 19389, 1930, 5455, 1927, 25985, 22083, 3]}, "items": [{"id": "p_1539", "content": "Organophosphates [SEP] Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or ", "score": 1, "type": null, "tokenized_content": [2, 3090, 15707, 1036, 3, 5056, 17, 3165, 3421, 1935, 2687, 8383, 18, 3063, 2441, 2052, 26300, 2032, 4300, 1988, 2162, 5056, 9030, 4124, 1942, 2340, 2014, 3]}]}
{"query": {"id": "q_1540", "content": "convulsions [SEP] Organophosphate-induced convulsions and prevention of neuropathological damages.", "tokenized_content": [2, 4772, 19389, 3, 3090, 15707, 17, 2719, 4772, 19389, 1930, 5455, 1927, 25985, 22083, 18, 3]}, "items": [{"id": "p_1540", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1541", "content": "neuropathological damages [SEP] Organophosphate-induced convulsions and prevention of neuropathological damages.", "tokenized_content": [2, 25985, 22083, 3, 3090, 15707, 17, 2719, 4772, 19389, 1930, 5455, 1927, 25985, 22083, 18, 3]}, "items": [{"id": "p_1541", "content": "Disease [SEP] A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts,", "score": 1, "type": null, "tokenized_content": [2, 2573, 3, 43, 15876, 11896, 2585, 1956, 43, 6293, 2735, 1927, 6879, 1930, 3601, 18, 2176, 2278, 4081, 1920, 4292, 3362, 2014, 2967, 1927, 2496, 7516, 16, 3]}]}
{"query": {"id": "q_1542", "content": "organophosphorus [SEP] Such organophosphorus (OP) compounds as diisopropylfluorophosphate (DFP), sarin and s", "tokenized_content": [2, 3090, 16847, 1957, 3, 2427, 3090, 16847, 1957, 12, 2494, 13, 4300, 1966, 26028, 2204, 20194, 2199, 14592, 15707, 12, 8122, 1034, 13, 16, 9851, 1921, 1930, 61, 3]}, "items": [{"id": "p_1542", "content": "Organophosphates [SEP] Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or ", "score": 1, "type": null, "tokenized_content": [2, 3090, 15707, 1036, 3, 5056, 17, 3165, 3421, 1935, 2687, 8383, 18, 3063, 2441, 2052, 26300, 2032, 4300, 1988, 2162, 5056, 9030, 4124, 1942, 2340, 2014, 3]}]}
{"query": {"id": "q_1543", "content": "OP [SEP] Such organophosphorus (OP) compounds as diisopropylfluorophosphate (DFP), sarin and soman", "tokenized_content": [2, 2494, 3, 2427, 3090, 16847, 1957, 12, 2494, 13, 4300, 1966, 26028, 2204, 20194, 2199, 14592, 15707, 12, 8122, 1034, 13, 16, 9851, 1921, 1930, 18078, 1022, 3]}, "items": [{"id": "p_1543", "content": "Organophosphates [SEP] Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or ", "score": 1, "type": null, "tokenized_content": [2, 3090, 15707, 1036, 3, 5056, 17, 3165, 3421, 1935, 2687, 8383, 18, 3063, 2441, 2052, 26300, 2032, 4300, 1988, 2162, 5056, 9030, 4124, 1942, 2340, 2014, 3]}]}
{"query": {"id": "q_1544", "content": "diisopropylfluorophosphate [SEP] Such organophosphorus (OP) compounds as diisopropylfluorophosphate (DFP), sarin and soman are potent inhibitors of acetylcholinest", "tokenized_content": [2, 26028, 2204, 20194, 2199, 14592, 15707, 3, 2427, 3090, 16847, 1957, 12, 2494, 13, 4300, 1966, 26028, 2204, 20194, 2199, 14592, 15707, 12, 8122, 1034, 13, 16, 9851, 1921, 1930, 3]}, "items": [{"id": "p_1544", "content": "Isoflurophate [SEP] A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4911, 12353, 2688, 2010, 3, 43, 2137, 17, 20500, 17, 16191, 25324, 2154, 1977, 1925, 14104, 15440, 2156, 7124, 4127, 4106, 2251, 1942, 4482, 1920, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1545", "content": "DFP [SEP]  organophosphorus (OP) compounds as diisopropylfluorophosphate (DFP), sarin and soman are potent inhibitors of acetylcholinesterase", "tokenized_content": [2, 8122, 1034, 3, 3090, 16847, 1957, 12, 2494, 13, 4300, 1966, 26028, 2204, 20194, 2199, 14592, 15707, 12, 8122, 1034, 13, 16, 9851, 1921, 1930, 18078, 1022, 2032, 6828, 4472, 3]}, "items": [{"id": "p_1545", "content": "Isoflurophate [SEP] A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4911, 12353, 2688, 2010, 3, 43, 2137, 17, 20500, 17, 16191, 25324, 2154, 1977, 1925, 14104, 15440, 2156, 7124, 4127, 4106, 2251, 1942, 4482, 1920, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_1546", "content": "sarin [SEP] ophosphorus (OP) compounds as diisopropylfluorophosphate (DFP), sarin and soman are potent inhibitors of acetylcholinesterases (AChEs", "tokenized_content": [2, 9851, 1921, 3, 11409, 2609, 1924, 1957, 12, 2494, 13, 4300, 1966, 26028, 2204, 20194, 2199, 14592, 15707, 12, 8122, 1034, 13, 16, 9851, 1921, 1930, 18078, 1022, 2032, 6828, 3]}, "items": [{"id": "p_1546", "content": "Sarin [SEP] An organophosphorus ester compound that produces potent and irreversible inhibition of cholinesterase. It is toxic to the nervou", "score": 1, "type": null, "tokenized_content": [2, 9851, 1921, 3, 1925, 3090, 16847, 1957, 9603, 3547, 1988, 9300, 6828, 1930, 14104, 3523, 1927, 15440, 2156, 7124, 4127, 18, 2176, 1977, 6161, 1942, 1920, 7342, 4468, 3]}]}
{"query": {"id": "q_1547", "content": "soman [SEP] s (OP) compounds as diisopropylfluorophosphate (DFP), sarin and soman are potent inhibitors of acetylcholinesterases (AChEs) and buty", "tokenized_content": [2, 18078, 1022, 3, 61, 12, 2494, 13, 4300, 1966, 26028, 2204, 20194, 2199, 14592, 15707, 12, 8122, 1034, 13, 16, 9851, 1921, 1930, 18078, 1022, 2032, 6828, 4472, 1927, 30003, 3]}, "items": [{"id": "p_1547", "content": "Soman [SEP] An organophosphorus compound that inhibits cholinesterase. It causes seizures and has been used as a chemical warfare agent.\n   ", "score": 1, "type": null, "tokenized_content": [2, 18078, 1022, 3, 1925, 3090, 16847, 1957, 3547, 1988, 7042, 15440, 2156, 7124, 4127, 18, 2176, 5092, 10060, 1930, 2258, 2252, 2251, 1966, 43, 4399, 15629, 2768, 5899, 18, 3]}]}
{"query": {"id": "q_1548", "content": "toxicity [SEP] esterases (AChEs) and butyrylcholinesterases (BChEs). The acute toxicity of OPs is the result of their irreversible binding with AChEs i", "tokenized_content": [2, 5532, 3, 26389, 1036, 12, 18564, 1036, 13, 1930, 2308, 28822, 27556, 1036, 12, 6452, 4483, 13, 18, 1920, 3939, 5532, 1927, 23569, 1977, 1920, 3211, 1927, 2310, 14104, 2743, 3]}, "items": [{"id": "p_1548", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1549", "content": "OPs [SEP] ChEs) and butyrylcholinesterases (BChEs). The acute toxicity of OPs is the result of their irreversible binding with AChEs in the c", "tokenized_content": [2, 23569, 3, 10003, 1036, 13, 1930, 2308, 28822, 27556, 1036, 12, 6452, 4483, 13, 18, 1920, 3939, 5532, 1927, 23569, 1977, 1920, 3211, 1927, 2310, 14104, 2743, 1956, 18564, 1036, 3]}, "items": [{"id": "p_1549", "content": "Organophosphates [SEP] Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or ", "score": 1, "type": null, "tokenized_content": [2, 3090, 15707, 1036, 3, 5056, 17, 3165, 3421, 1935, 2687, 8383, 18, 3063, 2441, 2052, 26300, 2032, 4300, 1988, 2162, 5056, 9030, 4124, 1942, 2340, 2014, 3]}]}
{"query": {"id": "q_1550", "content": "acetylcholine [SEP] fluorophosphate (DFP), sarin and soman are potent inhibitors of acetylcholinesterases (AChEs) and butyrylcholinesterases (BChEs). The acute t", "tokenized_content": [2, 14561, 3, 16191, 25324, 12, 8122, 1034, 13, 16, 9851, 1921, 1930, 18078, 1022, 2032, 6828, 4472, 1927, 30003, 1036, 12, 18564, 1036, 13, 1930, 2308, 28822, 27556, 1036, 12, 3]}, "items": [{"id": "p_1550", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_1551", "content": "ACh [SEP] sarin and soman are potent inhibitors of acetylcholinesterases (AChEs) and butyrylcholinesterases (BChEs). The acute toxicity of OP", "tokenized_content": [2, 3546, 3, 9851, 1921, 1930, 18078, 1022, 2032, 6828, 4472, 1927, 30003, 1036, 12, 18564, 1036, 13, 1930, 2308, 28822, 27556, 1036, 12, 6452, 4483, 13, 18, 1920, 3939, 5532, 3]}, "items": [{"id": "p_1551", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_1552", "content": "pralidoxime-2-chloride [SEP] ks-old Han-Wistar male rats. The rats received AChE reactivator pralidoxime-2-chloride (2PAM) (30.0 mg/kg BW), anticonvulsant diazepam (2.0 mg/kg BW),", "tokenized_content": [2, 21227, 12191, 22389, 29890, 17, 22, 17, 9140, 3, 11626, 17, 4156, 13087, 17, 15668, 4005, 3615, 18, 1920, 3615, 4004, 18564, 25136, 3061, 21227, 12191, 22389, 29890, 17, 22, 3]}, "items": [{"id": "p_1552", "content": "Pralidoxime Compounds [SEP] Various salts of a quaternary ammonium oxime that reconstitute inactivated acetylcholinesterase, especially at the neuromuscular", "score": 1, "type": null, "tokenized_content": [2, 21227, 12191, 22389, 29890, 4300, 3, 3425, 16028, 1927, 43, 21920, 11944, 21988, 1021, 1988, 10808, 2696, 11588, 30003, 16, 4369, 2019, 1920, 15829, 3]}]}
{"query": {"id": "q_1553", "content": "2PAM [SEP] ats. The rats received AChE reactivator pralidoxime-2-chloride (2PAM) (30.0 mg/kg BW), anticonvulsant diazepam (2.0 mg/kg BW), A(1)-", "tokenized_content": [2, 21981, 1976, 3, 19904, 18, 1920, 3615, 4004, 18564, 25136, 3061, 21227, 12191, 22389, 29890, 17, 22, 17, 9140, 12, 21981, 1976, 13, 12, 2627, 18, 20, 2786, 19, 3621, 3]}, "items": [{"id": "p_1553", "content": "Pralidoxime Compounds [SEP] Various salts of a quaternary ammonium oxime that reconstitute inactivated acetylcholinesterase, especially at the neuromuscular", "score": 1, "type": null, "tokenized_content": [2, 21227, 12191, 22389, 29890, 4300, 3, 3425, 16028, 1927, 43, 21920, 11944, 21988, 1021, 1988, 10808, 2696, 11588, 30003, 16, 4369, 2019, 1920, 15829, 3]}]}
{"query": {"id": "q_1554", "content": "diazepam [SEP] r pralidoxime-2-chloride (2PAM) (30.0 mg/kg BW), anticonvulsant diazepam (2.0 mg/kg BW), A(1)-adenosine receptor agonist N(6)-cyclopenty", "tokenized_content": [2, 26079, 3, 60, 21227, 12191, 22389, 29890, 17, 22, 17, 9140, 12, 21981, 1976, 13, 12, 2627, 18, 20, 2786, 19, 3621, 11534, 13, 16, 26572, 2031, 26079, 12, 22, 3]}, "items": [{"id": "p_1554", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_1555", "content": "adenosine [SEP] ) (30.0 mg/kg BW), anticonvulsant diazepam (2.0 mg/kg BW), A(1)-adenosine receptor agonist N(6)-cyclopentyl adenosine (CPA) (2.0 mg/kg BW", "tokenized_content": [2, 10125, 3, 13, 12, 2627, 18, 20, 2786, 19, 3621, 11534, 13, 16, 26572, 2031, 26079, 12, 22, 18, 20, 2786, 19, 3621, 11534, 13, 16, 43, 12, 21, 13, 3]}, "items": [{"id": "p_1555", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_1556", "content": "N(6)-cyclopentyl adenosine [SEP] ulsant diazepam (2.0 mg/kg BW), A(1)-adenosine receptor agonist N(6)-cyclopentyl adenosine (CPA) (2.0 mg/kg BW), NMDA-receptor antagonist dizocilpine male", "tokenized_content": [2, 56, 12, 26, 13, 17, 20585, 7528, 1024, 10125, 3, 3570, 5735, 4905, 26079, 12, 22, 18, 20, 2786, 19, 3621, 11534, 13, 16, 43, 12, 21, 13, 17, 10125, 3]}, "items": [{"id": "p_1556", "content": "N(6)-cyclopentyladenosine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 12, 26, 13, 17, 20585, 7528, 5148, 5233, 7506, 3, 3]}]}
{"query": {"id": "q_1557", "content": "CPA [SEP] W), A(1)-adenosine receptor agonist N(6)-cyclopentyl adenosine (CPA) (2.0 mg/kg BW), NMDA-receptor antagonist dizocilpine maleate (", "tokenized_content": [2, 22675, 3, 65, 13, 16, 43, 12, 21, 13, 17, 10125, 3148, 7829, 56, 12, 26, 13, 17, 20585, 7528, 1024, 10125, 12, 22675, 13, 12, 22, 18, 20, 2786, 3]}, "items": [{"id": "p_1557", "content": "N(6)-cyclopentyladenosine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 12, 26, 13, 17, 20585, 7528, 5148, 5233, 7506, 3, 3]}]}
{"query": {"id": "q_1558", "content": "NMDA [SEP] ceptor agonist N(6)-cyclopentyl adenosine (CPA) (2.0 mg/kg BW), NMDA-receptor antagonist dizocilpine maleate (+-MK801 hydrogen malea", "tokenized_content": [2, 10976, 3, 17008, 2684, 7829, 56, 12, 26, 13, 17, 20585, 7528, 1024, 10125, 12, 22675, 13, 12, 22, 18, 20, 2786, 19, 3621, 11534, 13, 16, 10976, 17, 3148, 3]}, "items": [{"id": "p_1558", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_1559", "content": "dizocilpine maleate [SEP] pentyl adenosine (CPA) (2.0 mg/kg BW), NMDA-receptor antagonist dizocilpine maleate (+-MK801 hydrogen maleate) (2.0 mg/kg BW) or their combinations", "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 9412, 2199, 10125, 12, 22675, 13, 12, 22, 18, 20, 2786, 19, 3621, 11534, 13, 16, 10976, 17, 3148, 8151, 2137, 13642, 10401, 3]}, "items": [{"id": "p_1559", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_1560", "content": "atropine sulfate [SEP] te) (2.0 mg/kg BW) or their combinations with cholinolytic drug atropine sulfate (50.0 mg/kg BW) immediately or 30 min after the single SC injec", "tokenized_content": [2, 24031, 8767, 3, 3602, 13, 12, 22, 18, 20, 2786, 19, 3621, 11534, 13, 2014, 2310, 7763, 1956, 6268, 21092, 4274, 2838, 24031, 8767, 12, 2761, 18, 20, 2786, 19, 3]}, "items": [{"id": "p_1560", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_1561", "content": "atropine [SEP] te) (2.0 mg/kg BW) or their combinations with cholinolytic drug atropine sulfate (50.0 mg/kg BW) immediately or 30 min after the single ", "tokenized_content": [2, 24031, 3, 3602, 13, 12, 22, 18, 20, 2786, 19, 3621, 11534, 13, 2014, 2310, 7763, 1956, 6268, 21092, 4274, 2838, 24031, 8767, 12, 2761, 18, 20, 2786, 19, 3621, 3]}, "items": [{"id": "p_1561", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_1562", "content": "poisoning [SEP] vented, delayed or shortened the occurrence of serious signs of poisoning. Atropine-MK801 did not offer any additional protection against", "tokenized_content": [2, 18722, 3, 14654, 1919, 16, 7083, 2014, 17112, 1920, 6564, 1927, 7433, 6879, 1927, 18722, 18, 24031, 17, 10539, 4476, 1009, 2811, 2084, 6260, 2967, 3281, 6202, 3316, 3]}, "items": [{"id": "p_1562", "content": "Poisoning [SEP] A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18722, 3, 43, 2625, 2014, 3841, 3360, 4152, 2007, 1920, 14195, 16, 4107, 16, 14728, 1927, 2014, 3395, 1942, 43, 12524, 5899, 18, 3]}]}
{"query": {"id": "q_1563", "content": "Atropine [SEP] ayed or shortened the occurrence of serious signs of poisoning. Atropine-MK801 did not offer any additional protection against DFP toxic", "tokenized_content": [2, 24031, 3, 15874, 1919, 2014, 17112, 1920, 6564, 1927, 7433, 6879, 1927, 18722, 18, 24031, 17, 10539, 4476, 1009, 2811, 2084, 6260, 2967, 3281, 6202, 3316, 8122, 1034, 6161, 3]}, "items": [{"id": "p_1563", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_1564", "content": "MK801 [SEP] (2.0 mg/kg BW), NMDA-receptor antagonist dizocilpine maleate (+-MK801 hydrogen maleate) (2.0 mg/kg BW) or their combinations with cho", "tokenized_content": [2, 10539, 4476, 1009, 3, 12, 22, 18, 20, 2786, 19, 3621, 11534, 13, 16, 10976, 17, 3148, 8151, 2137, 13642, 10401, 12184, 4005, 2010, 12, 15, 17, 10539, 4476, 1009, 3]}, "items": [{"id": "p_1564", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_1565", "content": "estrogen [SEP] Differential modulation by estrogen of alpha2-adrenergic and I1-imidazoline receptor-mediated hypot", "tokenized_content": [2, 7940, 3, 5611, 7145, 2007, 7940, 1927, 4595, 1028, 17, 13672, 1930, 27926, 17, 20697, 10457, 2053, 3148, 17, 3434, 12201, 3]}, "items": [{"id": "p_1565", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_1566", "content": "imidazoline [SEP] Differential modulation by estrogen of alpha2-adrenergic and I1-imidazoline receptor-mediated hypotension in female rats.", "tokenized_content": [2, 20697, 10457, 2053, 3, 5611, 7145, 2007, 7940, 1927, 4595, 1028, 17, 13672, 1930, 27926, 17, 20697, 10457, 2053, 3148, 17, 3434, 16453, 1922, 4232, 3615, 18, 3]}, "items": [{"id": "p_1566", "content": "Imidazolines [SEP] Compounds based on reduced IMIDAZOLES containing a single double bond.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20697, 10457, 2613, 3, 4300, 2454, 1990, 3028, 16045, 1036, 3165, 43, 2957, 4825, 5403, 18, 3]}]}
{"query": {"id": "q_1567", "content": "hypotension [SEP] rogen of alpha2-adrenergic and I1-imidazoline receptor-mediated hypotension in female rats.", "tokenized_content": [2, 16453, 3, 20443, 1917, 1927, 4595, 1028, 17, 13672, 1930, 27926, 17, 20697, 10457, 2053, 3148, 17, 3434, 16453, 1922, 4232, 3615, 18, 3]}, "items": [{"id": "p_1567", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1568", "content": "estrogen [SEP] We have recently shown that estrogen negatively modulates the hypotensive effect of clonidine (mixed", "tokenized_content": [2, 7940, 3, 2038, 2162, 3998, 2522, 1988, 7940, 7191, 13112, 1920, 12201, 3766, 2495, 1927, 26596, 12, 4985, 3]}, "items": [{"id": "p_1568", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_1569", "content": "hypotensive [SEP] We have recently shown that estrogen negatively modulates the hypotensive effect of clonidine (mixed alpha2-/I1-receptor agonist) in fema", "tokenized_content": [2, 12201, 3766, 3, 2038, 2162, 3998, 2522, 1988, 7940, 7191, 13112, 1920, 12201, 3766, 2495, 1927, 26596, 12, 4985, 4595, 1028, 17, 19, 27926, 17, 3148, 7829, 13, 1922, 3210, 3]}, "items": [{"id": "p_1569", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1570", "content": "clonidine [SEP] wn that estrogen negatively modulates the hypotensive effect of clonidine (mixed alpha2-/I1-receptor agonist) in female rats and implicat", "tokenized_content": [2, 26596, 3, 14191, 1988, 7940, 7191, 13112, 1920, 12201, 3766, 2495, 1927, 26596, 12, 4985, 4595, 1028, 17, 19, 27926, 17, 3148, 7829, 13, 1922, 4232, 3615, 1930, 6313, 6102, 3]}, "items": [{"id": "p_1570", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_1571", "content": "rilmenidine [SEP] eptors. Changes evoked by a single intraperitoneal injection of rilmenidine (600 microg/kg) or alpha-methyldopa (100 mg/kg), selective I1- ", "tokenized_content": [2, 20886, 19047, 5802, 3, 2630, 3448, 18, 2840, 8782, 2007, 43, 2957, 13006, 4107, 1927, 20886, 19047, 5802, 12, 8333, 12517, 19, 3621, 13, 2014, 4595, 17, 4963, 22389, 4302, 3]}, "items": [{"id": "p_1571", "content": "rilmenidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 20886, 19047, 5802, 3, 3]}]}
{"query": {"id": "q_1572", "content": "alpha-methyldopa [SEP] gle intraperitoneal injection of rilmenidine (600 microg/kg) or alpha-methyldopa (100 mg/kg), selective I1- and alpha2-receptor agonists, respec", "tokenized_content": [2, 4595, 17, 4963, 22389, 4302, 3, 16543, 13006, 4107, 1927, 20886, 19047, 5802, 12, 8333, 12517, 19, 3621, 13, 2014, 4595, 17, 4963, 22389, 4302, 12, 2813, 2786, 19, 3621, 3]}, "items": [{"id": "p_1572", "content": "Methyldopa [SEP] An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an ant", "score": 1, "type": null, "tokenized_content": [2, 4963, 22389, 4302, 3, 1925, 4595, 17, 22, 13672, 7829, 1988, 2258, 2321, 4101, 1930, 5009, 7580, 2433, 2564, 18, 2496, 3065, 2535, 2485, 1977, 1966, 1925, 4942, 3]}]}
{"query": {"id": "q_1573", "content": "hypotension [SEP] operated rats, rilmenidine or alpha-methyldopa elicited similar hypotension that lasted at least 5 h and was associated with reductions in ", "tokenized_content": [2, 16453, 3, 10497, 3615, 16, 20886, 19047, 5802, 2014, 4595, 17, 4963, 22389, 4302, 9856, 2551, 16453, 1988, 16276, 2019, 3464, 25, 50, 1930, 1982, 2458, 1956, 9350, 1922, 3]}, "items": [{"id": "p_1573", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1574", "content": "a reduced locomotor activity [SEP] n in Ovx rats was paralleled with further reduction in SDRR and a reduced locomotor activity. Estrogen replacement (17beta-estradiol subcutaneous pellet, 14", "tokenized_content": [2, 43, 3028, 13594, 2455, 3, 56, 1922, 19173, 3615, 1982, 23808, 1956, 2520, 3378, 1922, 4035, 18858, 1930, 43, 3028, 13594, 2455, 18, 7940, 7619, 12, 2752, 20440, 17, 11513, 3]}, "items": [{"id": "p_1574", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1575", "content": "17beta-estradiol [SEP] in SDRR and a reduced locomotor activity. Estrogen replacement (17beta-estradiol subcutaneous pellet, 14.2 microg/day, 12 wk) of Ovx rats restor", "tokenized_content": [2, 2752, 20440, 17, 11513, 3, 1922, 4035, 18858, 1930, 43, 3028, 13594, 2455, 18, 7940, 7619, 12, 2752, 20440, 17, 11513, 8634, 10963, 16, 2607, 18, 22, 12517, 19, 3007, 3]}, "items": [{"id": "p_1575", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_1576", "content": "tincture of Crataegus [SEP] Cardioprotective effect of tincture of Crataegus on isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 12347, 2341, 2027, 1927, 24422, 3857, 6541, 1957, 3, 28063, 2495, 1927, 12347, 2341, 2027, 1927, 24422, 3857, 6541, 1957, 1990, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_1576", "content": "crataegus extract [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24422, 3857, 6541, 1957, 5869, 3, 3]}]}
{"query": {"id": "q_1577", "content": "isoproterenol [SEP] Cardioprotective effect of tincture of Crataegus on isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 23743, 3, 28063, 2495, 1927, 12347, 2341, 2027, 1927, 24422, 3857, 6541, 1957, 1990, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_1577", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_1578", "content": "myocardial infarction [SEP] ective effect of tincture of Crataegus on isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 6497, 8358, 3, 7495, 2320, 2495, 1927, 12347, 2341, 2027, 1927, 24422, 3857, 6541, 1957, 1990, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_1578", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_1579", "content": "Tincture of Crataegus [SEP] Tincture of Crataegus (TCR), an alcoholic extract of the berries of hawthorn (Crataeg", "tokenized_content": [2, 12347, 2341, 2027, 1927, 24422, 3857, 6541, 1957, 3, 12347, 2341, 2027, 1927, 24422, 3857, 6541, 1957, 12, 8367, 13, 16, 1925, 15521, 5869, 1927, 1920, 28604, 2062, 1927, 19798, 3]}, "items": [{"id": "p_1579", "content": "crataegus extract [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24422, 3857, 6541, 1957, 5869, 3, 3]}]}
{"query": {"id": "q_1580", "content": "TCR [SEP] Tincture of Crataegus (TCR), an alcoholic extract of the berries of hawthorn (Crataegus ox", "tokenized_content": [2, 8367, 3, 12347, 2341, 2027, 1927, 24422, 3857, 6541, 1957, 12, 8367, 13, 16, 1925, 15521, 5869, 1927, 1920, 28604, 2062, 1927, 19798, 1963, 5578, 12, 24422, 3857, 6541, 1957, 3]}, "items": [{"id": "p_1580", "content": "crataegus extract [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24422, 3857, 6541, 1957, 5869, 3, 3]}]}
{"query": {"id": "q_1581", "content": "alcoholic extract of the berries of hawthorn [SEP] Tincture of Crataegus (TCR), an alcoholic extract of the berries of hawthorn (Crataegus oxycantha), is used in herbal and homeopathic medici", "tokenized_content": [2, 15521, 5869, 1927, 1920, 28604, 2062, 1927, 19798, 1963, 5578, 3, 12347, 2341, 2027, 1927, 24422, 3857, 6541, 1957, 12, 8367, 13, 16, 1925, 15521, 5869, 1927, 1920, 28604, 2062, 3]}, "items": [{"id": "p_1581", "content": "crataegus extract [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24422, 3857, 6541, 1957, 5869, 3, 3]}]}
{"query": {"id": "q_1582", "content": "Crataegus oxycantha [SEP] ataegus (TCR), an alcoholic extract of the berries of hawthorn (Crataegus oxycantha), is used in herbal and homeopathic medicine. The present study", "tokenized_content": [2, 24422, 3857, 6541, 1957, 20004, 8337, 1963, 1019, 3, 27382, 6541, 1957, 12, 8367, 13, 16, 1925, 15521, 5869, 1927, 1920, 28604, 2062, 1927, 19798, 1963, 5578, 12, 24422, 3857, 3]}, "items": [{"id": "p_1582", "content": "crataegus extract [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24422, 3857, 6541, 1957, 5869, 3, 3]}]}
{"query": {"id": "q_1583", "content": "myocardial infarction [SEP] estigate the protective effect of TCR on experimentally induced myocardial infarction in rats. Pretreatment of TCR, at a dose of 0.5 mL/100 g bodywei", "tokenized_content": [2, 6497, 8358, 3, 3255, 1950, 2010, 1920, 6337, 2495, 1927, 8367, 1990, 9568, 2719, 6497, 8358, 1922, 3615, 18, 9111, 1927, 8367, 16, 2019, 43, 3253, 1927, 20, 18, 25, 3]}, "items": [{"id": "p_1583", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_1584", "content": "isoproterenol [SEP] n lipid peroxidation and activity of marker enzymes observed in isoproterenol-induced rats (85 mg kg(-1) s. c. for 2 days at an interval of 2", "tokenized_content": [2, 23743, 3, 56, 4486, 14214, 1930, 2455, 1927, 4966, 5038, 2528, 1922, 23743, 17, 2719, 3615, 12, 5140, 2786, 3621, 12, 17, 21, 13, 61, 18, 45, 18, 1958, 22, 3]}, "items": [{"id": "p_1584", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_1585", "content": "ADP [SEP] e in antioxidant enzymes in the heart and increased the rate of ADP-stimulated oxygen uptake and respiratory coupling ratio. TCR pr", "tokenized_content": [2, 9828, 3, 47, 1922, 7335, 5038, 1922, 1920, 4003, 1930, 2502, 1920, 2769, 1927, 9828, 17, 5449, 4612, 5047, 1930, 5481, 7590, 3400, 18, 8367, 2033, 3]}, "items": [{"id": "p_1585", "content": "Adenosine Diphosphate [SEP] Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at ", "score": 1, "type": null, "tokenized_content": [2, 10125, 23266, 3, 10125, 25, 11, 17, 12, 5083, 8535, 2432, 23266, 13, 18, 1925, 15643, 5489, 3165, 2288, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 2019, 3]}]}
{"query": {"id": "q_1586", "content": "oxygen [SEP] t enzymes in the heart and increased the rate of ADP-stimulated oxygen uptake and respiratory coupling ratio. TCR protected against pa", "tokenized_content": [2, 4612, 3, 62, 5038, 1922, 1920, 4003, 1930, 2502, 1920, 2769, 1927, 9828, 17, 5449, 4612, 5047, 1930, 5481, 7590, 3400, 18, 8367, 9713, 3316, 3838, 3]}, "items": [{"id": "p_1586", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_1587", "content": "raloxifene [SEP] Safety and adverse effects associated with raloxifene: multiple outcomes of raloxifene evaluation.", "tokenized_content": [2, 15906, 12564, 1021, 3, 5407, 1930, 5246, 2564, 2458, 1956, 15906, 12564, 1021, 30, 3137, 3685, 1927, 15906, 12564, 1021, 4391, 18, 3]}, "items": [{"id": "p_1587", "content": "Raloxifene [SEP] A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has es", "score": 1, "type": null, "tokenized_content": [2, 15906, 12564, 1021, 3, 43, 2812, 4841, 5328, 7940, 3148, 18521, 12, 2375, 1035, 13, 2251, 1942, 4625, 12340, 1922, 14285, 3089, 18, 2176, 2258, 2376, 3]}]}
{"query": {"id": "q_1588", "content": "raloxifene [SEP] OBJECTIVE: To examine the effect of raloxifene on major adverse events that occur with postmenopausal estrogen", "tokenized_content": [2, 15906, 12564, 1021, 3, 4470, 30, 1942, 5020, 1920, 2495, 1927, 15906, 12564, 1021, 1990, 3044, 5246, 3916, 1988, 4704, 1956, 14285, 7940, 3]}, "items": [{"id": "p_1588", "content": "Raloxifene [SEP] A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has es", "score": 1, "type": null, "tokenized_content": [2, 15906, 12564, 1021, 3, 43, 2812, 4841, 5328, 7940, 3148, 18521, 12, 2375, 1035, 13, 2251, 1942, 4625, 12340, 1922, 14285, 3089, 18, 2176, 2258, 2376, 3]}]}
{"query": {"id": "q_1589", "content": "estrogen [SEP] loxifene on major adverse events that occur with postmenopausal estrogen therapy or tamoxifen. METHODS: The Multiple Outcomes of Raloxif", "tokenized_content": [2, 7940, 3, 11846, 10528, 2912, 1990, 3044, 5246, 3916, 1988, 4704, 1956, 14285, 7940, 3181, 2014, 13011, 18, 2860, 30, 1920, 3137, 3685, 1927, 15906, 11101, 3]}, "items": [{"id": "p_1589", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_1590", "content": "tamoxifen [SEP] verse events that occur with postmenopausal estrogen therapy or tamoxifen. METHODS: The Multiple Outcomes of Raloxifene Evaluation, a mul", "tokenized_content": [2, 13011, 3, 3162, 1021, 3916, 1988, 4704, 1956, 14285, 7940, 3181, 2014, 13011, 18, 2860, 30, 1920, 3137, 3685, 1927, 15906, 12564, 1021, 4391, 16, 43, 2556, 3]}, "items": [{"id": "p_1590", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_1591", "content": "Raloxifene [SEP] strogen therapy or tamoxifen. METHODS: The Multiple Outcomes of Raloxifene Evaluation, a multicenter, randomized, double-blind trial, enro", "tokenized_content": [2, 15906, 12564, 1021, 3, 4943, 2432, 3181, 2014, 13011, 18, 2860, 30, 1920, 3137, 3685, 1927, 15906, 12564, 1021, 4391, 16, 43, 14620, 16, 5542, 16, 4825, 17, 7109, 3046, 3]}, "items": [{"id": "p_1591", "content": "Raloxifene [SEP] A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has es", "score": 1, "type": null, "tokenized_content": [2, 15906, 12564, 1021, 3, 43, 2812, 4841, 5328, 7940, 3148, 18521, 12, 2375, 1035, 13, 2251, 1942, 4625, 12340, 1922, 14285, 3089, 18, 2176, 2258, 2376, 3]}]}
{"query": {"id": "q_1592", "content": "osteoporosis [SEP] d, double-blind trial, enrolled 7,705 postmenopausal women with osteoporosis. Women were randomly assigned to raloxifene 60 mg/d or 120 mg/d", "tokenized_content": [2, 12340, 3, 46, 16, 4825, 17, 7109, 3046, 16, 7316, 27, 16, 3895, 1015, 14285, 3089, 1956, 12340, 18, 3089, 1985, 6266, 6304, 1942, 15906, 12564, 1021, 3276, 2786, 19, 3]}, "items": [{"id": "p_1592", "content": "Osteoporosis [SEP] Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two m", "score": 1, "type": null, "tokenized_content": [2, 12340, 3, 3378, 1927, 3622, 3411, 2979, 10076, 1922, 1920, 5128, 1927, 3622, 16, 4523, 1942, 9018, 18, 3065, 12340, 2112, 1998, 1927, 2288, 55, 3]}]}
{"query": {"id": "q_1593", "content": "venous thromboembolism [SEP] to raloxifene 60 mg/d or 120 mg/d or placebo. Outcomes included venous thromboembolism, cataracts, gallbladder disease, and endometrial hyperplasia or", "tokenized_content": [2, 8562, 23821, 3, 1942, 15906, 12564, 1021, 3276, 2786, 19, 46, 2014, 6103, 2786, 19, 46, 2014, 5936, 18, 3685, 3063, 8562, 23821, 16, 14833, 1036, 16, 19358, 2573, 16, 3]}, "items": [{"id": "p_1593", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1594", "content": "cataracts [SEP]  120 mg/d or placebo. Outcomes included venous thromboembolism, cataracts, gallbladder disease, and endometrial hyperplasia or cancer. RE", "tokenized_content": [2, 14833, 1036, 3, 6103, 2786, 19, 46, 2014, 5936, 18, 3685, 3063, 8562, 23821, 16, 14833, 1036, 16, 19358, 2573, 16, 1930, 11634, 13095, 2014, 2539, 18, 1964, 3]}, "items": [{"id": "p_1594", "content": "Cataract [SEP] Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many ki", "score": 1, "type": null, "tokenized_content": [2, 14833, 3, 5740, 2014, 4080, 19888, 1999, 1990, 2014, 1922, 1920, 8540, 2014, 12174, 1927, 2340, 2014, 2321, 7127, 16, 25648, 9266, 2014, 7538, 19880, 18, 1920, 3086, 8191, 3]}]}
{"query": {"id": "q_1595", "content": "gallbladder disease [SEP] r placebo. Outcomes included venous thromboembolism, cataracts, gallbladder disease, and endometrial hyperplasia or cancer. RESULTS: During a mean ", "tokenized_content": [2, 19358, 2573, 3, 60, 5936, 18, 3685, 3063, 8562, 23821, 16, 14833, 1036, 16, 19358, 2573, 16, 1930, 11634, 13095, 2014, 2539, 18, 2274, 30, 2409, 43, 2667, 3]}, "items": [{"id": "p_1595", "content": "Gallbladder Diseases [SEP] Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, ne", "score": 1, "type": null, "tokenized_content": [2, 19358, 3902, 3, 3902, 1927, 1920, 19358, 18, 2611, 4933, 8156, 1920, 6159, 1927, 9619, 3426, 16, 9354, 22727, 1036, 1922, 1920, 13210, 6482, 16, 5024, 16, 2069, 3]}]}
{"query": {"id": "q_1596", "content": "endometrial hyperplasia [SEP] ded venous thromboembolism, cataracts, gallbladder disease, and endometrial hyperplasia or cancer. RESULTS: During a mean follow-up of 3.3 years, ralox", "tokenized_content": [2, 11634, 13095, 3, 11481, 8562, 23821, 16, 14833, 1036, 16, 19358, 2573, 16, 1930, 11634, 13095, 2014, 2539, 18, 2274, 30, 2409, 43, 2667, 2396, 17, 2353, 1927, 23, 18, 3]}, "items": [{"id": "p_1596", "content": "Endometrial Hyperplasia [SEP] Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissu", "score": 1, "type": null, "tokenized_content": [2, 11634, 13095, 3, 8867, 4031, 1927, 1920, 20694, 1922, 1920, 16297, 18, 11634, 13095, 1977, 5947, 2007, 2496, 16598, 1930, 21808, 2660, 1032, 3]}]}
{"query": {"id": "q_1597", "content": "endometrial cancer [SEP]  0.7-1.3), endometrial hyperplasia (RR 1.3; 95% CI 0.4-5.1), or endometrial cancer (RR 0.9; 95% CI 0.3-2.7). CONCLUSION: Raloxifene was associated", "tokenized_content": [2, 11634, 2539, 3, 20, 18, 27, 17, 21, 18, 23, 13, 16, 11634, 13095, 12, 5162, 21, 18, 23, 31, 3002, 9, 3371, 20, 18, 24, 17, 25, 18, 21, 3]}, "items": [{"id": "p_1597", "content": "Endometrial Neoplasms [SEP] Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classificati", "score": 1, "type": null, "tokenized_content": [2, 11634, 15347, 3, 3861, 2014, 2539, 1927, 20694, 16, 1920, 27103, 19402, 1927, 1920, 16297, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2310, 2921, 2077, 1968, 3]}]}
{"query": {"id": "q_1598", "content": "Ceftriaxone [SEP] Ceftriaxone-associated biliary pseudolithiasis in paediatric surgical patie", "tokenized_content": [2, 28248, 3, 28248, 17, 2458, 13210, 11520, 12191, 22523, 3932, 1922, 16658, 4548, 2091, 1021, 3]}, "items": [{"id": "p_1598", "content": "Ceftriaxone [SEP] A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.\n  ", "score": 1, "type": null, "tokenized_content": [2, 28248, 3, 43, 4949, 17, 5648, 25091, 1921, 7267, 1956, 43, 3345, 2815, 4768, 17, 3308, 1930, 2149, 8126, 2550, 1942, 10286, 1918, 16, 7127, 1930, 6671, 19332, 18, 3]}]}
{"query": {"id": "q_1599", "content": "biliary pseudolithiasis [SEP] Ceftriaxone-associated biliary pseudolithiasis in paediatric surgical patients.", "tokenized_content": [2, 13210, 11520, 12191, 22523, 3932, 3, 28248, 17, 2458, 13210, 11520, 12191, 22523, 3932, 1922, 16658, 4548, 2132, 18, 3]}, "items": [{"id": "p_1599", "content": "Biliary Tract Diseases [SEP] Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13210, 6482, 3902, 3, 3902, 1922, 2967, 3131, 1927, 1920, 13210, 6482, 2710, 1920, 9619, 19277, 1930, 1920, 19358, 18, 3]}]}
{"query": {"id": "q_1600", "content": "ceftriaxone [SEP] It is well known that ceftriaxone leads to pseudolithiasis in some patients. Clinical and experim", "tokenized_content": [2, 28248, 3, 2176, 1977, 2486, 3171, 1988, 28248, 5029, 1942, 11520, 12191, 22523, 3932, 1922, 2673, 2132, 18, 2535, 1930, 2533, 3]}, "items": [{"id": "p_1600", "content": "Ceftriaxone [SEP] A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.\n  ", "score": 1, "type": null, "tokenized_content": [2, 28248, 3, 43, 4949, 17, 5648, 25091, 1921, 7267, 1956, 43, 3345, 2815, 4768, 17, 3308, 1930, 2149, 8126, 2550, 1942, 10286, 1918, 16, 7127, 1930, 6671, 19332, 18, 3]}]}
{"query": {"id": "q_1601", "content": "pseudolithiasis [SEP] It is well known that ceftriaxone leads to pseudolithiasis in some patients. Clinical and experimental studies also sugges", "tokenized_content": [2, 11520, 12191, 22523, 3932, 3, 2176, 1977, 2486, 3171, 1988, 28248, 5029, 1942, 11520, 12191, 22523, 3932, 1922, 2673, 2132, 18, 2535, 1930, 3599, 2351, 2222, 2683, 3]}, "items": [{"id": "p_1601", "content": "Biliary Tract Diseases [SEP] Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13210, 6482, 3902, 3, 3902, 1922, 2967, 3131, 1927, 1920, 13210, 6482, 2710, 1920, 9619, 19277, 1930, 1920, 19358, 18, 3]}]}
{"query": {"id": "q_1602", "content": "gallbladder dysfunction [SEP] l and experimental studies also suggest that situations causing gallbladder dysfunction, such as fasting, may have a role for the development of pseudo", "tokenized_content": [2, 19358, 5273, 3, 54, 1930, 3599, 2351, 2222, 3220, 1988, 9370, 7538, 19358, 5273, 16, 2427, 1966, 8712, 16, 2278, 2162, 43, 2770, 1958, 1920, 2740, 1927, 11520, 3]}, "items": [{"id": "p_1602", "content": "Gallbladder Diseases [SEP] Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, ne", "score": 1, "type": null, "tokenized_content": [2, 19358, 3902, 3, 3902, 1927, 1920, 19358, 18, 2611, 4933, 8156, 1920, 6159, 1927, 9619, 3426, 16, 9354, 22727, 1036, 1922, 1920, 13210, 6482, 16, 5024, 16, 2069, 3]}]}
{"query": {"id": "q_1603", "content": "cocaine overdose [SEP] anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose.", "tokenized_content": [2, 9045, 21090, 3, 11693, 3375, 2053, 7172, 3533, 9005, 1030, 11884, 6951, 1966, 1925, 12748, 1958, 9045, 21090, 18, 3]}, "items": [{"id": "p_1603", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_1604", "content": "cocaine [SEP] The illicit use of cocaine continues in epidemic proportions and treatment for cocaine ove", "tokenized_content": [2, 9045, 3, 1920, 20881, 2485, 1927, 9045, 12455, 1922, 12107, 9766, 1930, 2311, 1958, 9045, 4285, 1021, 3]}, "items": [{"id": "p_1604", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1605", "content": "cocaine overdose [SEP]  of cocaine continues in epidemic proportions and treatment for cocaine overdose remains elusive. Current protein-based technology offers a new ", "tokenized_content": [2, 9045, 21090, 3, 1927, 9045, 12455, 1922, 12107, 9766, 1930, 2311, 1958, 9045, 21090, 4497, 17599, 18, 3214, 2213, 17, 2454, 5397, 9874, 43, 2814, 3]}, "items": [{"id": "p_1605", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_1606", "content": "toxicity [SEP]  3 min after cocaine treatment. Significant blockade of cocaine toxicity was observed with the higher dose of GNC92H2 (190 mg/kg), where", "tokenized_content": [2, 5532, 3, 23, 2360, 2256, 9045, 2311, 18, 2228, 9847, 1927, 9045, 5532, 1982, 2528, 1956, 1920, 2580, 3253, 1927, 9005, 1030, 11884, 6951, 12, 11981, 2786, 19, 3621, 13, 3]}, "items": [{"id": "p_1606", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1607", "content": "seizures [SEP]  (190 mg/kg), where premorbid behaviors were reduced up to 40%, seizures up to 77% and death by 72%. Importantly, GNC92H2 prevented deat", "tokenized_content": [2, 10060, 3, 12, 11981, 2786, 19, 3621, 13, 16, 2597, 6546, 4174, 1960, 5888, 1985, 3028, 2353, 1942, 3040, 9, 16, 10060, 2353, 1942, 5517, 9, 1930, 3539, 2007, 4395, 3]}, "items": [{"id": "p_1607", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1608", "content": "death [SEP] morbid behaviors were reduced up to 40%, seizures up to 77% and death by 72%. Importantly, GNC92H2 prevented death even post-cocaine ", "tokenized_content": [2, 3539, 3, 14296, 5888, 1985, 3028, 2353, 1942, 3040, 9, 16, 10060, 2353, 1942, 5517, 9, 1930, 3539, 2007, 4395, 9, 18, 6444, 16, 9005, 1030, 11884, 6951, 8715, 3539, 3]}, "items": [{"id": "p_1608", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_1609", "content": "raloxifene [SEP] The effects of short-term raloxifene therapy on fibrinolysis markers: TAFI, tPA, and PAI-1.", "tokenized_content": [2, 15906, 12564, 1021, 3, 1920, 2564, 1927, 3662, 17, 2576, 15906, 12564, 1021, 3181, 1990, 9450, 6892, 4432, 30, 19063, 1033, 16, 14555, 16, 1930, 15885, 17, 21, 18, 3]}, "items": [{"id": "p_1609", "content": "Raloxifene [SEP] A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has es", "score": 1, "type": null, "tokenized_content": [2, 15906, 12564, 1021, 3, 43, 2812, 4841, 5328, 7940, 3148, 18521, 12, 2375, 1035, 13, 2251, 1942, 4625, 12340, 1922, 14285, 3089, 18, 2176, 2258, 2376, 3]}]}
{"query": {"id": "q_1610", "content": "raloxifene [SEP] levels were studied for the evaluation of short-term effects of raloxifene administration in postmenopausal women. METHODS: Thirty-nine po", "tokenized_content": [2, 15906, 12564, 1021, 3, 2428, 1985, 3942, 1958, 1920, 4391, 1927, 3662, 17, 2576, 2564, 1927, 15906, 12564, 1021, 4183, 1922, 14285, 3089, 18, 2860, 30, 9942, 17, 6360, 2510, 3]}, "items": [{"id": "p_1610", "content": "Raloxifene [SEP] A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has es", "score": 1, "type": null, "tokenized_content": [2, 15906, 12564, 1021, 3, 43, 2812, 4841, 5328, 7940, 3148, 18521, 12, 2375, 1035, 13, 2251, 1942, 4625, 12340, 1922, 14285, 3089, 18, 2176, 2258, 2376, 3]}]}
{"query": {"id": "q_1611", "content": "osteopenia [SEP] enopausal women. METHODS: Thirty-nine postmenopausal women with osteopenia or osteoporosis were included in this prospective, controlled c", "tokenized_content": [2, 9668, 8572, 3, 2066, 10136, 3089, 18, 2860, 30, 9942, 17, 6360, 14285, 3089, 1956, 9668, 8572, 2014, 12340, 1985, 3063, 1922, 2052, 6315, 16, 4642, 45, 3]}, "items": [{"id": "p_1611", "content": "Bone Diseases, Metabolic [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 3902, 16, 4487, 3, 3]}]}
{"query": {"id": "q_1612", "content": "osteoporosis [SEP] n. METHODS: Thirty-nine postmenopausal women with osteopenia or osteoporosis were included in this prospective, controlled clinical study. T", "tokenized_content": [2, 12340, 3, 56, 18, 2860, 30, 9942, 17, 6360, 14285, 3089, 1956, 9668, 8572, 2014, 12340, 1985, 3063, 1922, 2052, 6315, 16, 4642, 2535, 2161, 18, 62, 3]}, "items": [{"id": "p_1612", "content": "Osteoporosis [SEP] Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two m", "score": 1, "type": null, "tokenized_content": [2, 12340, 3, 3378, 1927, 3622, 3411, 2979, 10076, 1922, 1920, 5128, 1927, 3622, 16, 4523, 1942, 9018, 18, 3065, 12340, 2112, 1998, 1927, 2288, 55, 3]}]}
{"query": {"id": "q_1613", "content": "raloxifene hydrochloride [SEP] ective, controlled clinical study. Twenty-five women were given raloxifene hydrochloride (60 mg/day) plus calcium (500 mg/day). Age-matched controls (n ", "tokenized_content": [2, 15906, 12564, 1021, 16675, 3, 7495, 2320, 16, 4642, 2535, 2161, 18, 7639, 17, 3628, 3089, 1985, 3258, 15906, 12564, 1021, 16675, 12, 3276, 2786, 19, 3007, 13, 5390, 5016, 3]}, "items": [{"id": "p_1613", "content": "Raloxifene [SEP] A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has es", "score": 1, "type": null, "tokenized_content": [2, 15906, 12564, 1021, 3, 43, 2812, 4841, 5328, 7940, 3148, 18521, 12, 2375, 1035, 13, 2251, 1942, 4625, 12340, 1922, 14285, 3089, 18, 2176, 2258, 2376, 3]}]}
{"query": {"id": "q_1614", "content": "calcium [SEP] five women were given raloxifene hydrochloride (60 mg/day) plus calcium (500 mg/day). Age-matched controls (n = 14) were given only cal", "tokenized_content": [2, 5016, 3, 3628, 3089, 1985, 3258, 15906, 12564, 1021, 16675, 12, 3276, 2786, 19, 3007, 13, 5390, 5016, 12, 4599, 2786, 19, 3007, 13, 18, 2632, 17, 5992, 3562, 12, 3]}, "items": [{"id": "p_1614", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_1615", "content": "amenorrhea [SEP] etween baseline TAFI antigen concentrations and the duration of amenorrhea (P < 0.05; r = 0.33). CONCLUSION: We suggest that the increased", "tokenized_content": [2, 15969, 21588, 3, 2140, 2189, 3703, 19063, 1033, 4730, 3295, 1930, 1920, 4392, 1927, 15969, 21588, 12, 58, 32, 20, 18, 2914, 31, 60, 33, 20, 18, 3401, 13, 18, 3]}, "items": [{"id": "p_1615", "content": "Amenorrhea [SEP] Absence of menstruation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15969, 21588, 3, 3905, 1927, 14333, 10874, 18, 3]}]}
{"query": {"id": "q_1616", "content": "venous thromboembolism [SEP] 5; r = 0.33). CONCLUSION: We suggest that the increased risk of venous thromboembolism due to raloxifene treatment may be related to increased tPA lev", "tokenized_content": [2, 8562, 23821, 3, 25, 31, 60, 33, 20, 18, 3401, 13, 18, 4180, 30, 2038, 3220, 1988, 1920, 2502, 2565, 1927, 8562, 23821, 2810, 1942, 15906, 12564, 1021, 2311, 2278, 3]}, "items": [{"id": "p_1616", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1617", "content": "Ketoconazole [SEP] Ketoconazole induced torsades de pointes without concomitant use of QT inter", "tokenized_content": [2, 21471, 12334, 6984, 3, 21471, 12334, 6984, 2719, 14823, 6363, 2028, 3575, 1918, 2979, 8537, 2485, 1927, 8877, 2107, 3]}, "items": [{"id": "p_1617", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_1618", "content": "torsades de pointes [SEP] Ketoconazole induced torsades de pointes without concomitant use of QT interval-prolonging drug.", "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 21471, 12334, 6984, 2719, 14823, 6363, 2028, 3575, 1918, 2979, 8537, 2485, 1927, 8877, 4979, 17, 6245, 1941, 2838, 18, 3]}, "items": [{"id": "p_1618", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_1619", "content": "Ketoconazole [SEP] Ketoconazole is not known to be proarrhythmic without concomitant use of QT ", "tokenized_content": [2, 21471, 12334, 6984, 3, 21471, 12334, 6984, 1977, 2084, 3171, 1942, 1998, 1965, 23246, 4913, 2979, 8537, 2485, 1927, 8877, 3]}, "items": [{"id": "p_1619", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_1620", "content": "coronary artery disease [SEP] ant use of QT interval-prolonging drugs. We report a woman with coronary artery disease who developed a markedly prolonged QT interval and torsades de ", "tokenized_content": [2, 5846, 5511, 2573, 3, 4942, 2485, 1927, 8877, 4979, 17, 6245, 1941, 4195, 18, 2038, 3809, 43, 10440, 1956, 5846, 5511, 2573, 2746, 3530, 43, 7686, 7171, 8877, 4979, 1930, 3]}, "items": [{"id": "p_1620", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_1621", "content": "prolonged QT interval [SEP] t a woman with coronary artery disease who developed a markedly prolonged QT interval and torsades de pointes (TdP) after taking ketoconazole for tre", "tokenized_content": [2, 7171, 8877, 4979, 3, 62, 43, 10440, 1956, 5846, 5511, 2573, 2746, 3530, 43, 7686, 7171, 8877, 4979, 1930, 14823, 6363, 2028, 3575, 1918, 12, 15390, 13, 2256, 6303, 21471, 3]}, "items": [{"id": "p_1621", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_1622", "content": "torsades de pointes [SEP] tery disease who developed a markedly prolonged QT interval and torsades de pointes (TdP) after taking ketoconazole for treatment of fungal infecti", "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 6005, 1012, 2573, 2746, 3530, 43, 7686, 7171, 8877, 4979, 1930, 14823, 6363, 2028, 3575, 1918, 12, 15390, 13, 2256, 6303, 21471, 12334, 6984, 3]}, "items": [{"id": "p_1622", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_1623", "content": "TdP [SEP] loped a markedly prolonged QT interval and torsades de pointes (TdP) after taking ketoconazole for treatment of fungal infection. H", "tokenized_content": [2, 15390, 3, 24910, 1007, 43, 7686, 7171, 8877, 4979, 1930, 14823, 6363, 2028, 3575, 1918, 12, 15390, 13, 2256, 6303, 21471, 12334, 6984, 1958, 2311, 1927, 8697, 2909, 18, 50, 3]}, "items": [{"id": "p_1623", "content": "Torsades de Pointes [SEP] A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute", "score": 1, "type": null, "tokenized_content": [2, 14823, 6363, 2028, 3575, 1918, 3, 43, 6558, 2386, 1927, 14240, 6493, 17397, 1988, 1977, 4378, 2007, 4003, 2769, 2192, 2191, 1930, 6330, 19380, 2079, 8623, 3]}]}
{"query": {"id": "q_1624", "content": "ketoconazole [SEP] rolonged QT interval and torsades de pointes (TdP) after taking ketoconazole for treatment of fungal infection. Her QT interval returned to ", "tokenized_content": [2, 21471, 12334, 6984, 3, 29144, 18771, 1007, 8877, 4979, 1930, 14823, 6363, 2028, 3575, 1918, 12, 15390, 13, 2256, 6303, 21471, 12334, 6984, 1958, 2311, 1927, 8697, 2909, 18, 3656, 3]}, "items": [{"id": "p_1624", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_1625", "content": "fungal infection [SEP] des de pointes (TdP) after taking ketoconazole for treatment of fungal infection. Her QT interval returned to normal upon withdrawal of ketocona", "tokenized_content": [2, 8697, 2909, 3, 2270, 2028, 3575, 1918, 12, 15390, 13, 2256, 6303, 21471, 12334, 6984, 1958, 2311, 1927, 8697, 2909, 18, 3656, 8877, 4979, 10418, 1942, 2791, 4073, 9594, 1927, 3]}, "items": [{"id": "p_1625", "content": "Mycoses [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5078, 12278, 3, 3]}]}
{"query": {"id": "q_1626", "content": "long QT syndrome [SEP] zole is administered to patients with risk factors for acquired long QT syndrome.", "tokenized_content": [2, 2815, 8877, 4741, 3, 21483, 1021, 1977, 5254, 1942, 2132, 1956, 2565, 2790, 1958, 5815, 2815, 8877, 4741, 18, 3]}, "items": [{"id": "p_1626", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_1627", "content": "cognitive dysfunctions [SEP] vidence for the potential of Daucus carota in the management of cognitive dysfunctions.", "tokenized_content": [2, 4328, 24199, 3, 7376, 15895, 1021, 1958, 1920, 2889, 1927, 3692, 1978, 1957, 7790, 3857, 1922, 1920, 4280, 1927, 4328, 24199, 18, 3]}, "items": [{"id": "p_1627", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_1628", "content": "cholesterol [SEP] ects of Daucus carota seeds on cognitive functions, total serum cholesterol levels and brain cholinesterase activity in mice. The ethanolic", "tokenized_content": [2, 5463, 3, 7495, 1036, 1927, 3692, 1978, 1957, 7790, 3857, 9869, 1990, 4328, 4088, 16, 2698, 3256, 5463, 2428, 1930, 3068, 15440, 2156, 7124, 4127, 2455, 1922, 2518, 18, 1920, 3]}, "items": [{"id": "p_1628", "content": "Cholesterol [SEP] The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fat", "score": 1, "type": null, "tokenized_content": [2, 5463, 3, 1920, 7944, 20408, 1927, 2136, 2580, 3555, 16, 6533, 1922, 3362, 3878, 16, 4369, 1920, 3068, 1930, 6071, 6670, 16, 1930, 1922, 4027, 3777, 3]}]}
{"query": {"id": "q_1629", "content": "extract of Daucus carota seeds [SEP] levels and brain cholinesterase activity in mice. The ethanolic extract of Daucus carota seeds (DCE) was administered orally in three doses (100, 200, 400 mg/", "tokenized_content": [2, 5869, 1927, 3692, 1978, 1957, 7790, 3857, 9869, 3, 2428, 1930, 3068, 15440, 2156, 7124, 4127, 2455, 1922, 2518, 18, 1920, 5757, 1935, 5869, 1927, 3692, 1978, 1957, 7790, 3857, 3]}, "items": [{"id": "p_1629", "content": "Plant Extracts [SEP] Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is ev", "score": 1, "type": null, "tokenized_content": [2, 4496, 6391, 3, 9421, 11106, 9815, 1927, 4793, 2926, 2007, 11340, 3500, 14423, 1956, 43, 6947, 7596, 16, 2154, 1977, 2180, 3]}]}
{"query": {"id": "q_1630", "content": "DCE [SEP] activity in mice. The ethanolic extract of Daucus carota seeds (DCE) was administered orally in three doses (100, 200, 400 mg/kg) f", "tokenized_content": [2, 23861, 3, 2455, 1922, 2518, 18, 1920, 5757, 1935, 5869, 1927, 3692, 1978, 1957, 7790, 3857, 9869, 12, 23861, 13, 1982, 5254, 12950, 1922, 2559, 5312, 12, 2813, 16, 2191, 3]}, "items": [{"id": "p_1630", "content": "Plant Extracts [SEP] Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is ev", "score": 1, "type": null, "tokenized_content": [2, 4496, 6391, 3, 9421, 11106, 9815, 1927, 4793, 2926, 2007, 11340, 3500, 14423, 1956, 43, 6947, 7596, 16, 2154, 1977, 2180, 3]}]}
{"query": {"id": "q_1631", "content": "Diazepam [SEP] rved as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine- and ageing-induced amnesia served as the interoc", "tokenized_content": [2, 26079, 3, 8309, 1919, 1966, 1920, 2897, 6506, 21380, 5343, 3130, 1958, 4213, 4525, 18, 26079, 17, 16, 25392, 10173, 25157, 17, 1930, 15559, 17, 2719, 14701, 7156, 9599, 1966, 3]}, "items": [{"id": "p_1631", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_1632", "content": "scopolamine [SEP]  exteroceptive behavioral models for testing memory. Diazepam-, scopolamine- and ageing-induced amnesia served as the interoceptive behavio", "tokenized_content": [2, 25392, 10173, 25157, 3, 2897, 6506, 21380, 5343, 3130, 1958, 4213, 4525, 18, 26079, 17, 16, 25392, 10173, 25157, 17, 1930, 15559, 17, 2719, 14701, 7156, 9599, 1966, 1920, 2107, 3]}, "items": [{"id": "p_1632", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_1633", "content": "amnesia [SEP]  for testing memory. Diazepam-, scopolamine- and ageing-induced amnesia served as the interoceptive behavioral models. DCE (200, 400 mg", "tokenized_content": [2, 14701, 7156, 3, 1958, 4213, 4525, 18, 26079, 17, 16, 25392, 10173, 25157, 17, 1930, 15559, 17, 2719, 14701, 7156, 9599, 1966, 1920, 2107, 20245, 2320, 5343, 3130, 18, 23861, 3]}, "items": [{"id": "p_1633", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_1634", "content": "diazepam [SEP] versed the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Daucus carota extract (200, 400 mg/kg, p.o.) r", "tokenized_content": [2, 26079, 3, 3162, 1919, 1920, 14701, 7156, 2719, 2007, 25392, 10173, 25157, 12, 20, 18, 24, 2786, 19, 3621, 16, 51, 18, 58, 18, 13, 1930, 26079, 12, 21, 2786, 3]}, "items": [{"id": "p_1634", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_1635", "content": "Daucus carota extract [SEP]  by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Daucus carota extract (200, 400 mg/kg, p.o.) reduced significantly the brain acetylch", "tokenized_content": [2, 3692, 1978, 1957, 7790, 3857, 5869, 3, 2007, 25392, 10173, 25157, 12, 20, 18, 24, 2786, 19, 3621, 16, 51, 18, 58, 18, 13, 1930, 26079, 12, 21, 2786, 19, 3]}, "items": [{"id": "p_1635", "content": "Plant Extracts [SEP] Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is ev", "score": 1, "type": null, "tokenized_content": [2, 4496, 6391, 3, 9421, 11106, 9815, 1927, 4793, 2926, 2007, 11340, 3500, 14423, 1956, 43, 6947, 7596, 16, 2154, 1977, 2180, 3]}]}
{"query": {"id": "q_1636", "content": "cognitive dysfunctions [SEP] fore, DCE may prove to be a useful remedy for the management of cognitive dysfunctions on account of its multifarious beneficial effects such as, memo", "tokenized_content": [2, 4328, 24199, 3, 9023, 16, 23861, 2278, 11948, 1942, 1998, 43, 4707, 17186, 1012, 1958, 1920, 4280, 1927, 4328, 24199, 1990, 5042, 1927, 2496, 15453, 26873, 6928, 2564, 2427, 1966, 3]}, "items": [{"id": "p_1636", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_1637", "content": "Cauda equina syndrome [SEP] Cauda equina syndrome after epidural steroid injection: a case report.", "tokenized_content": [2, 10268, 1019, 3009, 4058, 4741, 3, 10268, 1019, 3009, 4058, 4741, 2256, 17282, 9507, 4107, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_1637", "content": "Polyradiculopathy [SEP] Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.\n", "score": 1, "type": null, "tokenized_content": [2, 4286, 26208, 16058, 6522, 3, 2573, 2014, 4047, 5884, 3137, 6071, 5507, 9398, 18, 4286, 26208, 16058, 3678, 11238, 1942, 4531, 1927, 3137, 6071, 5507, 9398, 18, 3]}]}
{"query": {"id": "q_1638", "content": "steroid [SEP] Cauda equina syndrome after epidural steroid injection: a case report.", "tokenized_content": [2, 9507, 3, 10268, 1019, 3009, 4058, 4741, 2256, 17282, 9507, 4107, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_1638", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_1639", "content": "radiculopathy [SEP] OBJECTIVE: Conventional treatment methods of lumbusacral radiculopathy are physical therapy, epidural steroid injections, oral medicat", "tokenized_content": [2, 3271, 18021, 6012, 9112, 1012, 3, 4470, 30, 5552, 2311, 2860, 1927, 5491, 26835, 6312, 1923, 3271, 18021, 6012, 9112, 1012, 2032, 3841, 3181, 16, 17282, 9507, 8775, 16, 4726, 3]}, "items": [{"id": "p_1639", "content": "Radiculopathy [SEP] Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK ", "score": 1, "type": null, "tokenized_content": [2, 3271, 18021, 6012, 9112, 1012, 3, 2573, 5884, 43, 6071, 5507, 5904, 12, 3365, 6071, 5507, 9398, 13, 2154, 2278, 3211, 2037, 10399, 2712, 1942, 26575, 15598, 3]}]}
{"query": {"id": "q_1640", "content": "steroid [SEP] ods of lumbusacral radiculopathy are physical therapy, epidural steroid injections, oral medications, and spinal manipulative therapy. ", "tokenized_content": [2, 9507, 3, 4426, 1036, 1927, 5491, 26835, 6312, 1923, 3271, 18021, 6012, 9112, 1012, 2032, 3841, 3181, 16, 17282, 9507, 8775, 16, 4726, 7719, 16, 1930, 6071, 7239, 7797, 3181, 3]}, "items": [{"id": "p_1640", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_1641", "content": "Cauda equina syndrome [SEP]  injections, oral medications, and spinal manipulative therapy. Cauda equina syndrome is a rare complication of epidural anesthesia. The following ca", "tokenized_content": [2, 10268, 1019, 3009, 4058, 4741, 3, 8775, 16, 4726, 7719, 16, 1930, 6071, 7239, 7797, 3181, 18, 10268, 1019, 3009, 4058, 4741, 1977, 43, 5844, 9388, 1927, 17282, 8871, 18, 3]}, "items": [{"id": "p_1641", "content": "Polyradiculopathy [SEP] Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.\n", "score": 1, "type": null, "tokenized_content": [2, 4286, 26208, 16058, 6522, 3, 2573, 2014, 4047, 5884, 3137, 6071, 5507, 9398, 18, 4286, 26208, 16058, 3678, 11238, 1942, 4531, 1927, 3137, 6071, 5507, 9398, 18, 3]}]}
{"query": {"id": "q_1642", "content": "cauda equina syndrome [SEP] ation of epidural anesthesia. The following case is a report of cauda equina syndrome possibly caused by epidural injection of triamcinolone and bupi", "tokenized_content": [2, 10268, 1019, 3009, 4058, 4741, 3, 2019, 2001, 1927, 17282, 8871, 18, 1920, 2894, 3087, 1977, 43, 3809, 1927, 10268, 1019, 3009, 4058, 4741, 6553, 4189, 2007, 17282, 4107, 1927, 3]}, "items": [{"id": "p_1642", "content": "Polyradiculopathy [SEP] Disease or injury involving multiple SPINAL NERVE ROOTS. Polyradiculitis refers to inflammation of multiple spinal nerve roots.\n", "score": 1, "type": null, "tokenized_content": [2, 4286, 26208, 16058, 6522, 3, 2573, 2014, 4047, 5884, 3137, 6071, 5507, 9398, 18, 4286, 26208, 16058, 3678, 11238, 1942, 4531, 1927, 3137, 6071, 5507, 9398, 18, 3]}]}
{"query": {"id": "q_1643", "content": "triamcinolone [SEP]  cauda equina syndrome possibly caused by epidural injection of triamcinolone and bupivacaine. CLINICAL FEATURES: A 50-year-old woman with lo", "tokenized_content": [2, 5083, 1976, 3665, 13048, 3, 10268, 1019, 3009, 4058, 4741, 6553, 4189, 2007, 17282, 4107, 1927, 5083, 1976, 3665, 13048, 1930, 25473, 18, 2535, 4075, 30, 43, 2761, 17, 2476, 3]}, "items": [{"id": "p_1643", "content": "Triamcinolone [SEP] A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, o", "score": 1, "type": null, "tokenized_content": [2, 5083, 1976, 3665, 13048, 3, 43, 14469, 3258, 16, 1966, 1920, 3294, 4284, 2014, 1922, 9603, 2828, 2386, 16, 12950, 16, 16774, 1954, 16, 2007, 3076, 4107, 16, 2007, 14728, 16, 57, 3]}]}
{"query": {"id": "q_1644", "content": "bupivacaine [SEP] rome possibly caused by epidural injection of triamcinolone and bupivacaine. CLINICAL FEATURES: A 50-year-old woman with low back and right", "tokenized_content": [2, 25473, 3, 29660, 6553, 4189, 2007, 17282, 4107, 1927, 5083, 1976, 3665, 13048, 1930, 25473, 18, 2535, 4075, 30, 43, 2761, 17, 2476, 17, 4156, 10440, 1956, 2330, 3231, 1930, 3]}, "items": [{"id": "p_1644", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_1645", "content": "pain [SEP] NICAL FEATURES: A 50-year-old woman with low back and right leg pain was scheduled for epidural steroid injection. INTERVENTION AND ", "tokenized_content": [2, 3594, 3, 11188, 1923, 4075, 30, 43, 2761, 17, 2476, 17, 4156, 10440, 1956, 2330, 3231, 1930, 3659, 6703, 3594, 1982, 14962, 1958, 17282, 9507, 4107, 18, 3280, 1930, 3]}, "items": [{"id": "p_1645", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_1646", "content": "triamcinolone diacetate [SEP] ic imaging. After verifying the epidural space, bupivacaine and triamcinolone diacetate were injected. After the injection, there was a reduction in ra", "tokenized_content": [2, 5083, 1976, 3665, 13048, 25141, 1972, 3857, 2057, 3, 3996, 3755, 18, 2256, 10491, 1941, 1920, 17282, 5230, 16, 25473, 1930, 5083, 1976, 3665, 13048, 25141, 1972, 3857, 2057, 1985, 3]}, "items": [{"id": "p_1646", "content": "triamcinolone diacetate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5083, 1976, 3665, 13048, 25141, 1972, 3857, 2057, 3, 3]}]}
{"query": {"id": "q_1647", "content": "numbness [SEP] dicular symptoms. Three hours later, she complained of perineal numbness and lower extremity weakness. The neurologic evaluation reveale", "tokenized_content": [2, 25646, 2971, 3, 9192, 2168, 3601, 18, 2559, 3967, 3690, 16, 4693, 26199, 1927, 20238, 1923, 25646, 2971, 1930, 2826, 14884, 12175, 18, 1920, 14314, 4391, 3157, 1021, 3]}, "items": [{"id": "p_1647", "content": "Hypesthesia [SEP] Absent or reduced sensitivity to cutaneous stimulation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2483, 29259, 3, 7685, 2014, 3028, 3802, 1942, 11276, 4177, 18, 3]}]}
{"query": {"id": "q_1648", "content": "lower extremity weakness [SEP] oms. Three hours later, she complained of perineal numbness and lower extremity weakness. The neurologic evaluation revealed loss of sensation in the sa", "tokenized_content": [2, 2826, 14884, 12175, 3, 7254, 1036, 18, 2559, 3967, 3690, 16, 4693, 26199, 1927, 20238, 1923, 25646, 2971, 1930, 2826, 14884, 12175, 18, 1920, 14314, 4391, 3404, 3257, 1927, 15826, 3]}, "items": [{"id": "p_1648", "content": "Paraparesis [SEP] Mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHE", "score": 1, "type": null, "tokenized_content": [2, 22224, 9392, 1937, 3, 5809, 1942, 5086, 3257, 1927, 7787, 2826, 14884, 4842, 2347, 16, 2154, 2278, 1998, 43, 15570, 1927, 6071, 6670, 3902, 31, 4610, 4116, 3]}]}
{"query": {"id": "q_1649", "content": "loss of sensation [SEP] nd lower extremity weakness. The neurologic evaluation revealed loss of sensation in the saddle area and medial aspect of her right leg. There wa", "tokenized_content": [2, 3257, 1927, 15826, 3, 8026, 2826, 14884, 12175, 18, 1920, 14314, 4391, 3404, 3257, 1927, 15826, 1922, 1920, 12825, 5395, 3403, 1930, 7922, 9164, 1927, 3656, 3659, 6703, 18, 2276, 3]}, "items": [{"id": "p_1649", "content": "Hypesthesia [SEP] Absent or reduced sensitivity to cutaneous stimulation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2483, 29259, 3, 7685, 2014, 3028, 3802, 1942, 11276, 4177, 18, 3]}]}
{"query": {"id": "q_1650", "content": "neurologic deterioration [SEP] ions are rare. Clinical examination and continued vigilance for neurologic deterioration after epidural steroid injections is important.", "tokenized_content": [2, 14314, 13318, 3, 6982, 2032, 5844, 18, 2535, 4981, 1930, 7583, 27097, 1958, 14314, 13318, 2256, 17282, 9507, 8775, 1977, 2715, 18, 3]}, "items": [{"id": "p_1650", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_1651", "content": "testosterone [SEP] High-dose testosterone is associated with atherosclerosis in postmenopausal women.", "tokenized_content": [2, 10592, 3, 2149, 17, 3253, 10592, 1977, 2458, 1956, 9824, 1922, 14285, 3089, 18, 3]}, "items": [{"id": "p_1651", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_1652", "content": "atherosclerosis [SEP] High-dose testosterone is associated with atherosclerosis in postmenopausal women.", "tokenized_content": [2, 9824, 3, 2149, 17, 3253, 10592, 1977, 2458, 1956, 9824, 1922, 14285, 3089, 18, 3]}, "items": [{"id": "p_1652", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_1653", "content": "atherosclerosis [SEP] CTIVES: To study the long-term effects of androgen treatment on atherosclerosis in postmenopausal women. METHODS: In a population-based study i", "tokenized_content": [2, 9824, 3, 3369, 5706, 30, 1942, 2161, 1920, 2815, 17, 2576, 2564, 1927, 10817, 2311, 1990, 9824, 1922, 14285, 3089, 18, 2860, 30, 1922, 43, 2973, 17, 2454, 2161, 51, 3]}, "items": [{"id": "p_1653", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_1654", "content": "estrogen [SEP] on between self-reported intramuscularly administered high-dose estrogen-testosterone therapy (estradiol- and testosterone esters) and a", "tokenized_content": [2, 7940, 3, 1990, 2192, 3543, 17, 2568, 16774, 1954, 5254, 2149, 17, 3253, 7940, 17, 10592, 3181, 12, 11513, 17, 1930, 10592, 16785, 13, 1930, 43, 3]}, "items": [{"id": "p_1654", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_1655", "content": "testosterone [SEP] n self-reported intramuscularly administered high-dose estrogen-testosterone therapy (estradiol- and testosterone esters) and aortic atheros", "tokenized_content": [2, 10592, 3, 56, 3543, 17, 2568, 16774, 1954, 5254, 2149, 17, 3253, 7940, 17, 10592, 3181, 12, 11513, 17, 1930, 10592, 16785, 13, 1930, 7677, 7274, 1951, 3]}, "items": [{"id": "p_1655", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_1656", "content": "estradiol- and testosterone esters [SEP] uscularly administered high-dose estrogen-testosterone therapy (estradiol- and testosterone esters) and aortic atherosclerosis. Aortic atherosclerosis was diagnos", "tokenized_content": [2, 11513, 17, 1930, 10592, 16785, 3, 2022, 18021, 5148, 1005, 1954, 5254, 2149, 17, 3253, 7940, 17, 10592, 3181, 12, 11513, 17, 1930, 10592, 16785, 13, 1930, 7677, 9824, 18, 3]}, "items": [{"id": "p_1656", "content": "ethynodiol testosterone ester [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3293, 2304, 15799, 1945, 10592, 9603, 3, 3]}]}
{"query": {"id": "q_1657", "content": "diabetes [SEP] ndex). The association remained after additional adjustment for diabetes, cholesterol level, systolic blood pressure, or alcohol use. No", "tokenized_content": [2, 4032, 3, 27594, 1039, 13, 18, 1920, 3279, 5410, 2256, 3281, 7970, 1958, 4032, 16, 5463, 2237, 16, 8541, 2877, 3772, 16, 2014, 4284, 2485, 18, 2239, 3]}, "items": [{"id": "p_1657", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_1658", "content": "cholesterol [SEP]  association remained after additional adjustment for diabetes, cholesterol level, systolic blood pressure, or alcohol use. No association ", "tokenized_content": [2, 5463, 3, 3279, 5410, 2256, 3281, 7970, 1958, 4032, 16, 5463, 2237, 16, 8541, 2877, 3772, 16, 2014, 4284, 2485, 18, 2239, 3279, 3]}, "items": [{"id": "p_1658", "content": "Cholesterol [SEP] The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fat", "score": 1, "type": null, "tokenized_content": [2, 5463, 3, 1920, 7944, 20408, 1927, 2136, 2580, 3555, 16, 6533, 1922, 3362, 3878, 16, 4369, 1920, 3068, 1930, 6071, 6670, 16, 1930, 1922, 4027, 3777, 3]}]}
{"query": {"id": "q_1659", "content": "alcohol [SEP] nt for diabetes, cholesterol level, systolic blood pressure, or alcohol use. No association was found for hormone use less than 1 year.", "tokenized_content": [2, 4284, 3, 5891, 1958, 4032, 16, 5463, 2237, 16, 8541, 2877, 3772, 16, 2014, 4284, 2485, 18, 2239, 3279, 1982, 2435, 1958, 6365, 2485, 2941, 2254, 21, 2476, 18, 3]}, "items": [{"id": "p_1659", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_1660", "content": "Sirolimus [SEP] Sirolimus-associated proteinuria and renal dysfunction.", "tokenized_content": [2, 4520, 24124, 3, 4520, 24124, 17, 2458, 15831, 1930, 4604, 5273, 18, 3]}, "items": [{"id": "p_1660", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_1661", "content": "proteinuria [SEP] Sirolimus-associated proteinuria and renal dysfunction.", "tokenized_content": [2, 15831, 3, 4520, 24124, 17, 2458, 15831, 1930, 4604, 5273, 18, 3]}, "items": [{"id": "p_1661", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_1662", "content": "renal dysfunction [SEP] Sirolimus-associated proteinuria and renal dysfunction.", "tokenized_content": [2, 4604, 5273, 3, 4520, 24124, 17, 2458, 15831, 1930, 4604, 5273, 18, 3]}, "items": [{"id": "p_1662", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1663", "content": "Sirolimus [SEP] Sirolimus is a novel immunosuppressant with potent antiproliferative acti", "tokenized_content": [2, 4520, 24124, 3, 4520, 24124, 1977, 43, 4008, 27996, 2031, 1956, 6828, 21447, 4033, 1033, 3]}, "items": [{"id": "p_1663", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_1664", "content": "rapamycin [SEP] ts ability to inhibit the raptor-containing mammalian target of rapamycin protein kinase. Sirolimus represents a major therapeutic advanc", "tokenized_content": [2, 11100, 3, 4894, 3682, 1942, 2875, 1920, 30495, 17, 3165, 6492, 2758, 1927, 11100, 2213, 4016, 18, 4520, 24124, 4972, 43, 3044, 4272, 3277, 2412, 3]}, "items": [{"id": "p_1664", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_1665", "content": "nephropathy [SEP] ention of acute renal allograft rejection and chronic allograft nephropathy. Its role in the therapy of glomerulonephritis, autoimmunity, c", "tokenized_content": [2, 15582, 3, 5080, 1916, 1927, 3939, 4604, 15941, 10820, 1930, 3724, 15941, 15582, 18, 2496, 2770, 1922, 1920, 3181, 1927, 27057, 16, 17715, 16, 45, 3]}, "items": [{"id": "p_1665", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1666", "content": "glomerulonephritis [SEP] n and chronic allograft nephropathy. Its role in the therapy of glomerulonephritis, autoimmunity, cystic renal diseases and renal cancer is under ", "tokenized_content": [2, 27057, 3, 56, 1930, 3724, 15941, 15582, 18, 2496, 2770, 1922, 1920, 3181, 1927, 27057, 16, 17715, 16, 11656, 4604, 3902, 1930, 4604, 2539, 1977, 2441, 3]}, "items": [{"id": "p_1666", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_1667", "content": "autoimmunity [SEP] aft nephropathy. Its role in the therapy of glomerulonephritis, autoimmunity, cystic renal diseases and renal cancer is under investigation.", "tokenized_content": [2, 17715, 3, 2221, 1031, 15582, 18, 2496, 2770, 1922, 1920, 3181, 1927, 27057, 16, 17715, 16, 11656, 4604, 3902, 1930, 4604, 2539, 1977, 2441, 5630, 18, 3]}, "items": [{"id": "p_1667", "content": "Autoimmune Diseases [SEP] Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are ", "score": 1, "type": null, "tokenized_content": [2, 8904, 3902, 3, 4414, 1988, 2032, 4378, 2007, 1920, 3372, 1927, 3788, 1988, 9793, 1956, 4423, 3878, 2014, 3743, 7917, 2094, 1988, 2032, 3]}]}
{"query": {"id": "q_1668", "content": "cystic renal diseases [SEP] y. Its role in the therapy of glomerulonephritis, autoimmunity, cystic renal diseases and renal cancer is under investigation. Because sirolimus does", "tokenized_content": [2, 11656, 4604, 3902, 3, 67, 18, 2496, 2770, 1922, 1920, 3181, 1927, 27057, 16, 17715, 16, 11656, 4604, 3902, 1930, 4604, 2539, 1977, 2441, 5630, 18, 2882, 4520, 24124, 3731, 3]}, "items": [{"id": "p_1668", "content": "Kidney Diseases, Cystic [SEP] A heterogeneous group of hereditary and acquired disorders in which the KIDNEY contains one or more CYSTS unilaterally or bilate", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 16, 11656, 3, 43, 8538, 2210, 1927, 16321, 1930, 5815, 4414, 1922, 2154, 1920, 5245, 5461, 2340, 2014, 2253, 13270, 12059, 1954, 2014, 5088, 2010, 3]}]}
{"query": {"id": "q_1669", "content": "renal cancer [SEP]  of glomerulonephritis, autoimmunity, cystic renal diseases and renal cancer is under investigation. Because sirolimus does not share the va", "tokenized_content": [2, 4604, 2539, 3, 1927, 27057, 16, 17715, 16, 11656, 4604, 3902, 1930, 4604, 2539, 1977, 2441, 5630, 18, 2882, 4520, 24124, 3731, 2084, 7948, 1920, 9315, 3]}, "items": [{"id": "p_1669", "content": "Kidney Neoplasms [SEP] Tumors or cancers of the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 15347, 3, 3861, 2014, 5717, 1927, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_1670", "content": "sirolimus [SEP] renal diseases and renal cancer is under investigation. Because sirolimus does not share the vasomotor renal adverse effects exhibited by", "tokenized_content": [2, 4520, 24124, 3, 4604, 3902, 1930, 4604, 2539, 1977, 2441, 5630, 18, 2882, 4520, 24124, 3731, 2084, 7948, 1920, 22866, 12492, 2684, 4604, 5246, 2564, 5065, 2007, 3]}, "items": [{"id": "p_1670", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_1671", "content": "nephrotoxic [SEP] ibited by calcineurin inhibitors, it has been designated a 'non-nephrotoxic drug'. However, clinical reports suggest that, under some circu", "tokenized_content": [2, 22994, 10605, 3, 6180, 2599, 2007, 19555, 4472, 16, 2176, 2258, 2252, 10176, 43, 11, 2447, 17, 22994, 10605, 2838, 11, 18, 2406, 16, 2535, 4710, 3220, 1988, 16, 2441, 3]}, "items": [{"id": "p_1671", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1672", "content": "proteinuria [SEP] st that, under some circumstances, sirolimus is associated with proteinuria and acute renal dysfunction. A common risk factor appears to be", "tokenized_content": [2, 15831, 3, 1955, 1988, 16, 2441, 2673, 12294, 16, 4520, 24124, 1977, 2458, 1956, 15831, 1930, 3939, 4604, 5273, 18, 43, 3059, 2565, 2991, 5107, 1942, 1998, 3]}, "items": [{"id": "p_1672", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_1673", "content": "acute renal dysfunction [SEP] ome circumstances, sirolimus is associated with proteinuria and acute renal dysfunction. A common risk factor appears to be presence of pre-existing ch", "tokenized_content": [2, 3939, 4604, 5273, 3, 12453, 12294, 16, 4520, 24124, 1977, 2458, 1956, 15831, 1930, 3939, 4604, 5273, 18, 43, 3059, 2565, 2991, 5107, 1942, 1998, 2990, 1927, 2097, 17, 6124, 3]}, "items": [{"id": "p_1673", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_1674", "content": "chronic renal damage [SEP] on. A common risk factor appears to be presence of pre-existing chronic renal damage. The mechanisms of sirolimus-associated proteinuria are multifa", "tokenized_content": [2, 3724, 4604, 4293, 3, 1990, 18, 43, 3059, 2565, 2991, 5107, 1942, 1998, 2990, 1927, 2097, 17, 6124, 3724, 4604, 4293, 18, 1920, 3531, 1927, 4520, 24124, 17, 2458, 15831, 3]}, "items": [{"id": "p_1674", "content": "Renal Insufficiency, Chronic [SEP] Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is class", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 16, 3724, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1958, 2253, 2254, 2559, 3221, 18, 3724, 5245, 14566, 1977, 2921, 3]}]}
{"query": {"id": "q_1675", "content": "angiotensin [SEP] ons, close monitoring of proteinuria and renal function, use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blocker", "tokenized_content": [2, 10814, 3, 24335, 16, 5428, 5378, 1927, 15831, 1930, 4604, 2347, 16, 2485, 1927, 10814, 17, 15025, 4113, 4472, 2014, 10814, 2890, 3148, 14580, 3]}, "items": [{"id": "p_1675", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_1676", "content": "angiotensin II [SEP] al function, use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers if proteinuria occurs and withdrawal if neede", "tokenized_content": [2, 10814, 2890, 3, 1969, 2347, 16, 2485, 1927, 10814, 17, 15025, 4113, 4472, 2014, 10814, 2890, 3148, 13628, 2647, 15831, 5110, 1930, 9594, 2647, 2942, 1021, 3]}, "items": [{"id": "p_1676", "content": "Angiotensin II [SEP] An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino aci", "score": 1, "type": null, "tokenized_content": [2, 10814, 2890, 3, 1925, 5843, 24010, 1988, 1977, 43, 6828, 2308, 22001, 28404, 2684, 18, 2176, 1977, 4152, 2037, 10814, 51, 2256, 1920, 6025, 1927, 2288, 3835, 2000, 1033, 3]}]}
{"query": {"id": "q_1677", "content": "myopathy [SEP] Progressive myopathy with up-regulation of MHC-I associated with statin therapy.", "tokenized_content": [2, 25017, 3, 7529, 25017, 1956, 2353, 17, 3640, 1927, 8709, 17, 51, 2458, 1956, 10838, 3181, 18, 3]}, "items": [{"id": "p_1677", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_1678", "content": "statin [SEP] rogressive myopathy with up-regulation of MHC-I associated with statin therapy.", "tokenized_content": [2, 10838, 3, 20443, 4479, 2320, 25017, 1956, 2353, 17, 3640, 1927, 8709, 17, 51, 2458, 1956, 10838, 3181, 18, 3]}, "items": [{"id": "p_1678", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_1679", "content": "Statins [SEP] Statins can cause a necrotizing myopathy and hyperCKaemia which is reve", "tokenized_content": [2, 15511, 3, 15511, 2112, 3936, 43, 27438, 25017, 1930, 14338, 7640, 3847, 2154, 1977, 3084, 3]}, "items": [{"id": "p_1679", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_1680", "content": "myopathy [SEP] Statins can cause a necrotizing myopathy and hyperCKaemia which is reversible on cessation of the drug. ", "tokenized_content": [2, 25017, 3, 15511, 2112, 3936, 43, 27438, 25017, 1930, 14338, 7640, 3847, 2154, 1977, 10743, 1990, 10975, 1927, 1920, 2838, 18, 3]}, "items": [{"id": "p_1680", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_1681", "content": "statins [SEP] on of the drug. What is less well known is a phenomenon whereby statins may induce a myopathy, which persists or may progress after sto", "tokenized_content": [2, 15511, 3, 1990, 1927, 1920, 2838, 18, 4663, 1977, 2941, 2486, 3171, 1977, 43, 7902, 12507, 15511, 2278, 4769, 43, 25017, 16, 2154, 20350, 2014, 2278, 4782, 2256, 13046, 3]}, "items": [{"id": "p_1681", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_1682", "content": "necrosis [SEP] stigated the muscle pathology in 8 such cases. All had myofibre necrosis but only 3 had an inflammatory infiltrate. In all cases there w", "tokenized_content": [2, 7476, 3, 11303, 1981, 1920, 3760, 6819, 1922, 28, 2427, 2919, 18, 2136, 2430, 26565, 1021, 7476, 2308, 2444, 23, 2430, 1925, 3769, 19155, 18, 1922, 2136, 2919, 2276, 65, 3]}, "items": [{"id": "p_1682", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_1683", "content": "necrotic [SEP] use or multifocal up-regulation of MHC-I expression even in non-necrotic fibres. Progressive improvement occurred in 7 cases after comme", "tokenized_content": [2, 14275, 3, 2485, 2014, 21632, 2353, 17, 3640, 1927, 8709, 17, 51, 2294, 3385, 1922, 2447, 17, 14275, 15157, 18, 7529, 4990, 4807, 1922, 27, 2919, 2256, 2689, 1021, 3]}, "items": [{"id": "p_1683", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_1684", "content": "prednisolone [SEP] ogressive improvement occurred in 7 cases after commencement of prednisolone and methotrexate, and in one case spontaneously. These observat", "tokenized_content": [2, 22025, 3, 17395, 4479, 2320, 4990, 4807, 1922, 27, 2919, 2256, 27492, 2017, 1927, 22025, 1930, 18031, 16, 1930, 1922, 2340, 3087, 12753, 18, 2144, 3634, 1926, 3]}, "items": [{"id": "p_1684", "content": "Prednisolone [SEP] A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routin", "score": 1, "type": null, "tokenized_content": [2, 22025, 3, 43, 14469, 1956, 1920, 3335, 3879, 1927, 1920, 14610, 18, 2176, 1977, 1920, 2838, 1927, 6259, 1958, 2136, 2961, 1922, 2154, 10276, 3]}]}
{"query": {"id": "q_1685", "content": "methotrexate [SEP] ment occurred in 7 cases after commencement of prednisolone and methotrexate, and in one case spontaneously. These observations suggest that", "tokenized_content": [2, 18031, 3, 11567, 4807, 1922, 27, 2919, 2256, 27492, 2017, 1927, 22025, 1930, 18031, 16, 1930, 1922, 2340, 3087, 12753, 18, 2144, 5184, 3220, 1988, 3]}, "items": [{"id": "p_1685", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_1686", "content": "cyclic nucleotide [SEP] Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine.", "tokenized_content": [2, 9821, 5489, 3, 3083, 3523, 1927, 4435, 24946, 17, 4128, 9821, 5489, 17, 12336, 20876, 5628, 2007, 26596, 18, 3]}, "items": [{"id": "p_1686", "content": "Nucleotides, Cyclic [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9519, 16, 9821, 3, 3]}]}
{"query": {"id": "q_1687", "content": "clonidine [SEP] ization-activated cyclic nucleotide-gated pacemaker channels by clonidine.", "tokenized_content": [2, 26596, 3, 25455, 1943, 17, 4128, 9821, 5489, 17, 12336, 20876, 5628, 2007, 26596, 18, 3]}, "items": [{"id": "p_1687", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_1688", "content": "cardiovascular disease [SEP] pathetic tone represents an important strategy for treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic hear", "tokenized_content": [2, 5321, 2573, 3, 2450, 3023, 11020, 4972, 1925, 2715, 4884, 1958, 2311, 1927, 5321, 2573, 16, 2710, 18346, 16, 5846, 4003, 2573, 16, 1930, 3724, 3563, 3]}, "items": [{"id": "p_1688", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_1689", "content": "arrhythmia [SEP] ant strategy for treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic heart failure. Activation ", "tokenized_content": [2, 18346, 3, 4942, 4884, 1958, 2311, 1927, 5321, 2573, 16, 2710, 18346, 16, 5846, 4003, 2573, 16, 1930, 3724, 4003, 4574, 18, 2936, 3]}, "items": [{"id": "p_1689", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_1690", "content": "coronary heart disease [SEP]  for treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic heart failure. Activation of presynaptic alpha2-ad", "tokenized_content": [2, 5846, 4003, 2573, 3, 1958, 2311, 1927, 5321, 2573, 16, 2710, 18346, 16, 5846, 4003, 2573, 16, 1930, 3724, 4003, 4574, 18, 2936, 1927, 13111, 4595, 1028, 17, 2041, 3]}, "items": [{"id": "p_1690", "content": "Coronary Disease [SEP] An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow", "score": 1, "type": null, "tokenized_content": [2, 5846, 2573, 3, 1925, 14093, 2192, 6497, 3183, 8456, 1930, 1920, 4796, 1927, 1920, 5846, 7208, 1942, 9042, 5409, 2877, 3426, 3]}]}
{"query": {"id": "q_1691", "content": "heart failure [SEP] ease, including arrhythmia, coronary heart disease, and chronic heart failure. Activation of presynaptic alpha2-adrenoceptors is the most wid", "tokenized_content": [2, 4003, 4574, 3, 13832, 16, 2710, 18346, 16, 5846, 4003, 2573, 16, 1930, 3724, 4003, 4574, 18, 2936, 1927, 13111, 4595, 1028, 17, 25090, 1036, 1977, 1920, 2501, 4530, 3]}, "items": [{"id": "p_1691", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_1692", "content": "clonidine [SEP] widely accepted mechanism of action of the antisympathetic drug clonidine; however, other target proteins have been postulated to contrib", "tokenized_content": [2, 26596, 3, 5673, 8131, 2856, 1927, 4615, 1927, 1920, 8059, 23395, 2838, 26596, 31, 2406, 16, 2303, 2758, 2697, 2162, 2252, 14024, 1942, 3380, 3]}, "items": [{"id": "p_1692", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_1693", "content": "Clonidine [SEP] antly lowered heart rate in alpha2ABC-/- mice by up to 150 bpm. Clonidine-induced bradycardia in conscious alpha2ABC-/- mice was 32.3% (1", "tokenized_content": [2, 26596, 3, 4942, 1954, 13786, 4003, 2769, 1922, 4595, 5896, 8284, 17, 19, 17, 2518, 2007, 2353, 1942, 5493, 23370, 18, 26596, 17, 2719, 26192, 1922, 11993, 4595, 5896, 8284, 3]}, "items": [{"id": "p_1693", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_1694", "content": "bradycardia [SEP] t rate in alpha2ABC-/- mice by up to 150 bpm. Clonidine-induced bradycardia in conscious alpha2ABC-/- mice was 32.3% (10 microg/kg) and 26.", "tokenized_content": [2, 26192, 3, 62, 2769, 1922, 4595, 5896, 8284, 17, 19, 17, 2518, 2007, 2353, 1942, 5493, 23370, 18, 26596, 17, 2719, 26192, 1922, 11993, 4595, 5896, 8284, 17, 19, 17, 3]}, "items": [{"id": "p_1694", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_1695", "content": "cyclic nucleotide [SEP] maker cells and the I(f)-generating hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 and HCN4 channels in transfected HEK293 cells. As", "tokenized_content": [2, 9821, 5489, 3, 5144, 1005, 2094, 1930, 1920, 51, 12, 48, 13, 17, 9155, 24946, 17, 4128, 9821, 5489, 17, 12336, 12, 4387, 1022, 13, 22, 1930, 4387, 15580, 5628, 3]}, "items": [{"id": "p_1695", "content": "Nucleotides, Cyclic [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9519, 16, 9821, 3, 3]}]}
{"query": {"id": "q_1696", "content": "smoking [SEP] Influence of smoking on developing cochlea. Does smoking during pregnancy affect the", "tokenized_content": [2, 5075, 3, 4039, 1927, 5075, 1990, 5130, 23310, 18, 3731, 5075, 2409, 5284, 4081, 1920, 3]}, "items": [{"id": "p_1696", "content": "Smoke [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11587, 3, 3]}]}
{"query": {"id": "q_1697", "content": "smoking [SEP] OBJECTIVE: Maternal tobacco smoking has negative effects on fetal growth. The influence of smoking ", "tokenized_content": [2, 5075, 3, 4470, 30, 5509, 7729, 5075, 2258, 3136, 2564, 1990, 5944, 2905, 18, 1920, 4039, 1927, 5075, 3]}, "items": [{"id": "p_1697", "content": "Smoke [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11587, 3, 3]}]}
{"query": {"id": "q_1698", "content": "hearing loss [SEP] estimated, although smoking has been positively associated with hearing loss in adults. The objective of this study was to determine the eff", "tokenized_content": [2, 8512, 3257, 3, 4185, 16, 2876, 5075, 2258, 2252, 6629, 2458, 1956, 8512, 3257, 1922, 4440, 18, 1920, 4470, 1927, 2052, 2161, 1982, 1942, 3415, 1920, 2121, 3]}, "items": [{"id": "p_1698", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_1699", "content": "hearing impairment [SEP] DS: This study was undertaken as part of neonatal screening for hearing impairment and involved both ears of 200 newborns. Newborns whose mothers ", "tokenized_content": [2, 8512, 6159, 3, 4473, 30, 2052, 2161, 1982, 10466, 1966, 3131, 1927, 7985, 4449, 1958, 8512, 6159, 1930, 3286, 2321, 19332, 1927, 2191, 16026, 18, 16026, 6098, 7026, 3]}, "items": [{"id": "p_1699", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_1700", "content": "Neuroinflammation [SEP] Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatme", "tokenized_content": [2, 20582, 3, 20582, 1930, 5343, 6754, 2256, 7985, 6005, 16119, 8177, 2297, 3870, 3]}, "items": [{"id": "p_1700", "content": "Neurogenic Inflammation [SEP] Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascul", "score": 1, "type": null, "tokenized_content": [2, 21113, 4531, 3, 4531, 4189, 2007, 1925, 3734, 4836, 5794, 1927, 5009, 3558, 1930, 3864, 1922, 4012, 1927, 26839, 2154, 4081, 10205, 3]}]}
{"query": {"id": "q_1701", "content": "behavioral abnormalities [SEP] Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for ", "tokenized_content": [2, 5343, 6754, 3, 20582, 1930, 5343, 6754, 2256, 7985, 6005, 16119, 8177, 2311, 1922, 3615, 30, 7020, 1958, 3]}, "items": [{"id": "p_1701", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1702", "content": "terbutaline [SEP] Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism.", "tokenized_content": [2, 6005, 16119, 8177, 3, 20582, 1930, 5343, 6754, 2256, 7985, 6005, 16119, 8177, 2311, 1922, 3615, 30, 7020, 1958, 10862, 18, 3]}, "items": [{"id": "p_1702", "content": "Terbutaline [SEP] A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6005, 16119, 8177, 3, 43, 5328, 4666, 17, 22, 13672, 7829, 2251, 1966, 43, 26272, 3061, 1930, 21682, 6586, 18, 3]}]}
{"query": {"id": "q_1703", "content": "autism [SEP]  after neonatal terbutaline treatment in rats: implications for autism.", "tokenized_content": [2, 10862, 3, 2256, 7985, 6005, 16119, 8177, 2311, 1922, 3615, 30, 7020, 1958, 10862, 18, 3]}, "items": [{"id": "p_1703", "content": "Autistic Disorder [SEP] A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interacti", "score": 1, "type": null, "tokenized_content": [2, 22694, 4770, 3, 43, 4770, 7828, 1922, 7238, 18, 2176, 1977, 4961, 2007, 1920, 2990, 1927, 7686, 4552, 2014, 5761, 2740, 1922, 3686, 6310, 1033, 3]}]}
{"query": {"id": "q_1704", "content": "Autism [SEP] Autism is a neurodevelopmental disorder presenting before 3 years of a", "tokenized_content": [2, 10862, 3, 10862, 1977, 43, 19055, 4770, 8326, 3119, 23, 2739, 1927, 43, 3]}, "items": [{"id": "p_1704", "content": "Autistic Disorder [SEP] A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interacti", "score": 1, "type": null, "tokenized_content": [2, 22694, 4770, 3, 43, 4770, 7828, 1922, 7238, 18, 2176, 1977, 4961, 2007, 1920, 2990, 1927, 7686, 4552, 2014, 5761, 2740, 1922, 3686, 6310, 1033, 3]}]}
{"query": {"id": "q_1705", "content": "neurodevelopmental disorder [SEP] Autism is a neurodevelopmental disorder presenting before 3 years of age with deficits in communication", "tokenized_content": [2, 19055, 4770, 3, 10862, 1977, 43, 19055, 4770, 8326, 3119, 23, 2739, 1927, 2632, 1956, 7961, 1922, 6396, 3]}, "items": [{"id": "p_1705", "content": "Developmental Disabilities [SEP] Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These i", "score": 1, "type": null, "tokenized_content": [2, 5878, 15529, 3, 4414, 1922, 2154, 2276, 1977, 43, 4989, 1922, 2740, 2454, 1990, 1988, 4100, 1958, 43, 3258, 2632, 2237, 2014, 3587, 1927, 2740, 18, 2144, 51, 3]}]}
{"query": {"id": "q_1706", "content": "deficits in communication and social skills [SEP] urodevelopmental disorder presenting before 3 years of age with deficits in communication and social skills and repetitive behaviors. In addition to genetic influences, re", "tokenized_content": [2, 7961, 1922, 6396, 1930, 3686, 7474, 3, 14984, 3695, 2374, 9600, 4770, 8326, 3119, 23, 2739, 1927, 2632, 1956, 7961, 1922, 6396, 1930, 3686, 7474, 1930, 12089, 5888, 18, 1922, 3]}, "items": [{"id": "p_1706", "content": "Communication Disorders [SEP] Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g", "score": 1, "type": null, "tokenized_content": [2, 6396, 4414, 3, 4414, 1927, 10011, 1930, 2447, 30056, 6396, 4189, 2007, 17308, 2014, 27599, 6357, 4414, 16, 4328, 5273, 12, 47, 18, 49, 3]}]}
{"query": {"id": "q_1707", "content": "repetitive behaviors [SEP] ars of age with deficits in communication and social skills and repetitive behaviors. In addition to genetic influences, recent studies suggest that", "tokenized_content": [2, 12089, 5888, 3, 9896, 1927, 2632, 1956, 7961, 1922, 6396, 1930, 3686, 7474, 1930, 12089, 5888, 18, 1922, 2459, 1942, 3299, 8061, 16, 3505, 2351, 3220, 1988, 3]}, "items": [{"id": "p_1707", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1708", "content": "autism [SEP] t that prenatal drug or chemical exposures are risk factors for autism. Terbutaline, a beta2-adrenoceptor agonist used to arrest prete", "tokenized_content": [2, 10862, 3, 62, 1988, 10907, 2838, 2014, 4399, 10043, 2032, 2565, 2790, 1958, 10862, 18, 6005, 16119, 8177, 16, 43, 4666, 1028, 17, 25090, 7829, 2251, 1942, 8048, 24532, 1021, 3]}, "items": [{"id": "p_1708", "content": "Autistic Disorder [SEP] A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interacti", "score": 1, "type": null, "tokenized_content": [2, 22694, 4770, 3, 43, 4770, 7828, 1922, 7238, 18, 2176, 1977, 4961, 2007, 1920, 2990, 1927, 7686, 4552, 2014, 5761, 2740, 1922, 3686, 6310, 1033, 3]}]}
{"query": {"id": "q_1709", "content": "Terbutaline [SEP] renatal drug or chemical exposures are risk factors for autism. Terbutaline, a beta2-adrenoceptor agonist used to arrest preterm labor, has", "tokenized_content": [2, 6005, 16119, 8177, 3, 3866, 4607, 2838, 2014, 4399, 10043, 2032, 2565, 2790, 1958, 10862, 18, 6005, 16119, 8177, 16, 43, 4666, 1028, 17, 25090, 7829, 2251, 1942, 8048, 10435, 3]}, "items": [{"id": "p_1709", "content": "Terbutaline [SEP] A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6005, 16119, 8177, 3, 43, 5328, 4666, 17, 22, 13672, 7829, 2251, 1966, 43, 26272, 3061, 1930, 21682, 6586, 18, 3]}]}
{"query": {"id": "q_1710", "content": "preterm labor [SEP] utism. Terbutaline, a beta2-adrenoceptor agonist used to arrest preterm labor, has been associated with increased concordance for autism in d", "tokenized_content": [2, 10435, 3876, 3, 21472, 18538, 18, 6005, 16119, 8177, 16, 43, 4666, 1028, 17, 25090, 7829, 2251, 1942, 8048, 10435, 3876, 16, 2258, 2252, 2458, 1956, 2502, 13911, 1958, 10862, 3]}, "items": [{"id": "p_1710", "content": "Obstetric Labor, Premature [SEP] Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime d", "score": 1, "type": null, "tokenized_content": [2, 18902, 3876, 16, 9839, 3, 4727, 1927, 18902, 3876, 3119, 2576, 12, 2576, 5043, 13, 2308, 5394, 2256, 1920, 15722, 2258, 5433, 8978, 18, 1922, 5209, 16, 2176, 5110, 2673, 6995, 46, 3]}]}
{"query": {"id": "q_1711", "content": "terbutaline [SEP] rdance for autism in dizygotic twins. We studied the effects of terbutaline on microglial activation in different brain regions and behavio", "tokenized_content": [2, 6005, 16119, 8177, 3, 8695, 2152, 1958, 10862, 1922, 2137, 1011, 4121, 3153, 16250, 18, 2038, 3942, 1920, 2564, 1927, 6005, 16119, 8177, 1990, 13810, 2936, 1922, 2413, 3068, 3451, 3]}, "items": [{"id": "p_1711", "content": "Terbutaline [SEP] A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6005, 16119, 8177, 3, 43, 5328, 4666, 17, 22, 13672, 7829, 2251, 1966, 43, 26272, 3061, 1930, 21682, 6586, 18, 3]}]}
{"query": {"id": "q_1712", "content": "behavioral abnormalities [SEP] ctivation associated with innate neuroinflammatory pathways and behavioral abnormalities, similar to those described in autism. This study provides a us", "tokenized_content": [2, 5343, 6754, 3, 3369, 10529, 2458, 1956, 8539, 3366, 9899, 3873, 1930, 5343, 6754, 16, 2551, 1942, 2690, 2910, 1922, 10862, 18, 2052, 2161, 4558, 43, 2022, 3]}, "items": [{"id": "p_1712", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1713", "content": "autism spectrum disorders [SEP] el for understanding the neuropathological processes underlying autism spectrum disorders.", "tokenized_content": [2, 10862, 5648, 4414, 3, 2349, 1958, 4339, 1920, 25985, 4028, 5030, 10862, 5648, 4414, 18, 3]}, "items": [{"id": "p_1713", "content": "Child Development Disorders, Pervasive [SEP] Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. Th", "score": 1, "type": null, "tokenized_content": [2, 2748, 2740, 4414, 16, 26728, 3, 4010, 26593, 1922, 1920, 2740, 1927, 3086, 5937, 6674, 4088, 1988, 2032, 2084, 2791, 1958, 2967, 3587, 1922, 2740, 18, 1913, 3]}]}
{"query": {"id": "q_1714", "content": "myocarditis [SEP] Acute myocarditis associated with clozapine.", "tokenized_content": [2, 27169, 3, 3939, 27169, 2458, 1956, 24424, 18, 3]}, "items": [{"id": "p_1714", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_1715", "content": "clozapine [SEP] Acute myocarditis associated with clozapine.", "tokenized_content": [2, 24424, 3, 3939, 27169, 2458, 1956, 24424, 18, 3]}, "items": [{"id": "p_1715", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_1716", "content": "myocarditis [SEP] OBJECTIVE: A case of acute myocarditis associated with the commencement of clozapine is described, hig", "tokenized_content": [2, 27169, 3, 4470, 30, 43, 3087, 1927, 3939, 27169, 2458, 1956, 1920, 27492, 2017, 1927, 24424, 1977, 2910, 16, 21340, 3]}, "items": [{"id": "p_1716", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_1717", "content": "clozapine [SEP] A case of acute myocarditis associated with the commencement of clozapine is described, highlighting the onset, course and possible contr", "tokenized_content": [2, 24424, 3, 43, 3087, 1927, 3939, 27169, 2458, 1956, 1920, 27492, 2017, 1927, 24424, 1977, 2910, 16, 13903, 1920, 4727, 16, 4914, 1930, 3216, 2885, 3]}, "items": [{"id": "p_1717", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_1718", "content": "schizophrenia [SEP] complication of clozapine use. RESULTS: A 20-year-old male with schizophrenia developed a sudden onset of myocarditis after commencement of c", "tokenized_content": [2, 7899, 3, 9388, 1927, 24424, 2485, 18, 2274, 30, 43, 2036, 17, 2476, 17, 4156, 4005, 1956, 7899, 3530, 43, 12446, 4727, 1927, 27169, 2256, 27492, 2017, 1927, 45, 3]}, "items": [{"id": "p_1718", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_1719", "content": "antidepressant [SEP] etting. Possible contributing factors may have been concomitant antidepressant use and unaccustomed physical activity. CONCLUSIONS: Myocarditi", "tokenized_content": [2, 14183, 3, 2140, 2104, 18, 3216, 8739, 2790, 2278, 2162, 2252, 8537, 14183, 2485, 1930, 26844, 2437, 2892, 14028, 3841, 2455, 18, 4355, 30, 5779, 2078, 3]}, "items": [{"id": "p_1719", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_1720", "content": "Myocarditis [SEP] depressant use and unaccustomed physical activity. CONCLUSIONS: Myocarditis is an increasingly recognized complication associated with the ", "tokenized_content": [2, 27169, 3, 20852, 2031, 2485, 1930, 26844, 2437, 2892, 14028, 3841, 2455, 18, 4355, 30, 27169, 1977, 1925, 8827, 6783, 9388, 2458, 1956, 1920, 3]}, "items": [{"id": "p_1720", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_1721", "content": "psychosis [SEP] t clozapine remains the gold standard in treatment of resistant psychosis, there is an urgent need to raise awareness among medical and p", "tokenized_content": [2, 15489, 3, 62, 24424, 4497, 1920, 6557, 2970, 1922, 2311, 1927, 4910, 15489, 16, 2276, 1977, 1925, 15210, 2942, 1942, 13701, 8755, 2706, 3423, 1930, 58, 3]}, "items": [{"id": "p_1721", "content": "Psychotic Disorders [SEP] Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent halluc", "score": 1, "type": null, "tokenized_content": [2, 16651, 4414, 3, 4414, 1922, 2154, 2276, 1977, 43, 3257, 1927, 7282, 1037, 11471, 2014, 43, 10461, 6159, 1922, 15928, 4213, 1956, 2723, 3910, 2014, 8753, 20958, 3]}]}
{"query": {"id": "q_1722", "content": "Encephalopathy [SEP] Encephalopathy induced by levetiracetam added to valproate.", "tokenized_content": [2, 19393, 3, 19393, 2719, 2007, 10157, 4988, 5524, 1972, 3857, 1035, 4057, 1942, 23867, 2010, 18, 3]}, "items": [{"id": "p_1722", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_1723", "content": "levetiracetam [SEP] Encephalopathy induced by levetiracetam added to valproate.", "tokenized_content": [2, 10157, 4988, 5524, 1972, 3857, 1035, 3, 19393, 2719, 2007, 10157, 4988, 5524, 1972, 3857, 1035, 4057, 1942, 23867, 2010, 18, 3]}, "items": [{"id": "p_1723", "content": "etiracetam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8096, 5524, 1972, 3857, 1035, 3, 3]}]}
{"query": {"id": "q_1724", "content": "valproate [SEP] Encephalopathy induced by levetiracetam added to valproate.", "tokenized_content": [2, 23867, 2010, 3, 19393, 2719, 2007, 10157, 4988, 5524, 1972, 3857, 1035, 4057, 1942, 23867, 2010, 18, 3]}, "items": [{"id": "p_1724", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1725", "content": "levetiracetam [SEP] BACKGROUND: We report on the manifestation of a levetiracetam (LEV)-induced encephalopathy. FINDINGS: A 28-year-old man suffe", "tokenized_content": [2, 10157, 4988, 5524, 1972, 3857, 1035, 3, 3872, 30, 2038, 3809, 1990, 1920, 15570, 1927, 43, 10157, 4988, 5524, 1972, 3857, 1035, 12, 10157, 13, 17, 2719, 19393, 18, 3056, 3]}, "items": [{"id": "p_1725", "content": "etiracetam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8096, 5524, 1972, 3857, 1035, 3, 3]}]}
{"query": {"id": "q_1726", "content": "LEV [SEP] BACKGROUND: We report on the manifestation of a levetiracetam (LEV)-induced encephalopathy. FINDINGS: A 28-year-old man suffering ", "tokenized_content": [2, 10157, 3, 3872, 30, 2038, 3809, 1990, 1920, 15570, 1927, 43, 10157, 4988, 5524, 1972, 3857, 1035, 12, 10157, 13, 17, 2719, 19393, 18, 3056, 30, 43, 3158, 17, 2476, 3]}, "items": [{"id": "p_1726", "content": "etiracetam [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8096, 5524, 1972, 3857, 1035, 3, 3]}]}
{"query": {"id": "q_1727", "content": "encephalopathy [SEP] We report on the manifestation of a levetiracetam (LEV)-induced encephalopathy. FINDINGS: A 28-year-old man suffering from idiopathic epilepsy", "tokenized_content": [2, 19393, 3, 2038, 3809, 1990, 1920, 15570, 1927, 43, 10157, 4988, 5524, 1972, 3857, 1035, 12, 10157, 13, 17, 2719, 19393, 18, 3056, 30, 43, 3158, 17, 2476, 17, 4156, 3]}, "items": [{"id": "p_1727", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_1728", "content": "idiopathic epilepsy [SEP] uced encephalopathy. FINDINGS: A 28-year-old man suffering from idiopathic epilepsy with generalized seizures was treated with LEV (3000 mg) added ", "tokenized_content": [2, 13513, 9741, 3, 8577, 1919, 19393, 18, 3056, 30, 43, 3158, 17, 2476, 17, 4156, 2323, 11364, 2037, 13513, 9741, 1956, 9612, 10060, 1982, 2868, 1956, 10157, 12, 13491, 2786, 3]}, "items": [{"id": "p_1728", "content": "Epilepsy, Idiopathic Generalized [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 13513, 9612, 3, 3]}]}
{"query": {"id": "q_1729", "content": "seizures [SEP] ear-old man suffering from idiopathic epilepsy with generalized seizures was treated with LEV (3000 mg) added to valproate (VPA) (2000 m", "tokenized_content": [2, 10060, 3, 4352, 17, 4156, 2323, 11364, 2037, 13513, 9741, 1956, 9612, 10060, 1982, 2868, 1956, 10157, 12, 13491, 2786, 13, 4057, 1942, 23867, 2010, 12, 19703, 13, 12, 4314, 3]}, "items": [{"id": "p_1729", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1730", "content": "valproate [SEP] th generalized seizures was treated with LEV (3000 mg) added to valproate (VPA) (2000 mg). Frequency of generalized tonic-clonic seizures", "tokenized_content": [2, 23867, 2010, 3, 1913, 9612, 10060, 1982, 2868, 1956, 10157, 12, 13491, 2786, 13, 4057, 1942, 23867, 2010, 12, 19703, 13, 12, 4314, 2786, 13, 18, 3528, 1927, 9612, 16887, 3]}, "items": [{"id": "p_1730", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1731", "content": "VPA [SEP] zed seizures was treated with LEV (3000 mg) added to valproate (VPA) (2000 mg). Frequency of generalized tonic-clonic seizures incr", "tokenized_content": [2, 19703, 3, 6116, 1007, 10060, 1982, 2868, 1956, 10157, 12, 13491, 2786, 13, 4057, 1942, 23867, 2010, 12, 19703, 13, 12, 4314, 2786, 13, 18, 3528, 1927, 9612, 16887, 17, 3]}, "items": [{"id": "p_1731", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_1732", "content": "tonic-clonic seizures [SEP] g) added to valproate (VPA) (2000 mg). Frequency of generalized tonic-clonic seizures increased from one per 6 months to two per month. Neuropsycholo", "tokenized_content": [2, 16887, 17, 6138, 1935, 10060, 3, 49, 13, 4057, 1942, 23867, 2010, 12, 19703, 13, 12, 4314, 2786, 13, 18, 3528, 1927, 9612, 16887, 17, 6138, 1935, 10060, 2502, 2037, 3]}, "items": [{"id": "p_1732", "content": "Epilepsy, Tonic-Clonic [SEP] A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 16887, 17, 6138, 1935, 3, 43, 9612, 11015, 4770, 4378, 2007, 7457, 3044, 4842, 10060, 18, 1920, 3754, 5310, 16887, 3193, 1977, 4961, 2007, 13717, 3]}]}
{"query": {"id": "q_1733", "content": "impaired word fluency, psychomotor speed and working memory [SEP] er 6 months to two per month. Neuropsychological testing showed impaired word fluency, psychomotor speed and working memory. The interictal electroencephalogram (EEG) showed a generalized", "tokenized_content": [2, 5761, 5430, 19969, 16, 26261, 5986, 1930, 5905, 4525, 3, 2668, 26, 3221, 1942, 2288, 2079, 2935, 18, 14612, 4213, 2594, 5761, 5430, 19969, 16, 26261, 5986, 1930, 5905, 4525, 3]}, "items": [{"id": "p_1733", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_1734", "content": "seizure [SEP] ear-old man suffering from idiopathic epilepsy with generalized seizures was treated with LEV (3000 mg) added to valproate (VPA) (2000 ", "tokenized_content": [2, 11015, 3, 4352, 17, 4156, 2323, 11364, 2037, 13513, 9741, 1956, 9612, 10060, 1982, 2868, 1956, 10157, 12, 13491, 2786, 13, 4057, 1942, 23867, 2010, 12, 19703, 13, 12, 4314, 3]}, "items": [{"id": "p_1734", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1735", "content": "Norepinephrine [SEP] Norepinephrine signaling through beta-adrenergic receptors is critical for exp", "tokenized_content": [2, 16436, 3, 16436, 3197, 2596, 4666, 17, 13672, 4086, 1977, 4140, 1958, 2887, 3]}, "items": [{"id": "p_1735", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1736", "content": "cocaine [SEP] through beta-adrenergic receptors is critical for expression of cocaine-induced anxiety.", "tokenized_content": [2, 9045, 3, 2596, 4666, 17, 13672, 4086, 1977, 4140, 1958, 2294, 1927, 9045, 17, 2719, 5592, 18, 3]}, "items": [{"id": "p_1736", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1737", "content": "anxiety [SEP] energic receptors is critical for expression of cocaine-induced anxiety.", "tokenized_content": [2, 5592, 3, 2066, 5237, 4086, 1977, 4140, 1958, 2294, 1927, 9045, 17, 2719, 5592, 18, 3]}, "items": [{"id": "p_1737", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_1738", "content": "Cocaine [SEP] BACKGROUND: Cocaine is a widely abused psychostimulant that has both rewarding and ", "tokenized_content": [2, 9045, 3, 3872, 30, 9045, 1977, 43, 5673, 7764, 1007, 9855, 2265, 5617, 4905, 1988, 2258, 2321, 25894, 1930, 3]}, "items": [{"id": "p_1738", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1739", "content": "cocaine [SEP] arding and aversive properties. While the mechanisms underlying cocaine's rewarding effects have been studied extensively, less attenti", "tokenized_content": [2, 9045, 3, 2245, 2117, 1930, 21029, 3879, 18, 2679, 1920, 3531, 5030, 9045, 11, 61, 25894, 2564, 2162, 2252, 3942, 9172, 16, 2941, 5256, 1914, 3]}, "items": [{"id": "p_1739", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1740", "content": "anxiety [SEP] to the unpleasant behavioral states induced by cocaine, such as anxiety. METHODS: In this study, we evaluated the performance of dopami", "tokenized_content": [2, 5592, 3, 1942, 1920, 25429, 5343, 4376, 2719, 2007, 9045, 16, 2427, 1966, 5592, 18, 2860, 30, 1922, 2052, 2161, 16, 2038, 3747, 1920, 3604, 1927, 19428, 7395, 3]}, "items": [{"id": "p_1740", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_1741", "content": "dopamine [SEP] nxiety. METHODS: In this study, we evaluated the performance of dopamine beta-hydroxylase knockout (Dbh -/-) mice, which lack norepineph", "tokenized_content": [2, 7964, 3, 27578, 5111, 18, 2860, 30, 1922, 2052, 2161, 16, 2038, 3747, 1920, 3604, 1927, 7964, 4666, 17, 16324, 7949, 12, 6594, 1023, 17, 19, 17, 13, 2518, 16, 3]}, "items": [{"id": "p_1741", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1742", "content": "norepinephrine [SEP] f dopamine beta-hydroxylase knockout (Dbh -/-) mice, which lack norepinephrine (NE), in the elevated plus maze (EPM) to examine the contributi", "tokenized_content": [2, 16436, 3, 48, 7964, 4666, 17, 16324, 7949, 12, 6594, 1023, 17, 19, 17, 13, 2518, 16, 2154, 3630, 16436, 12, 2069, 13, 16, 1922, 1920, 4664, 5390, 14476, 12, 3]}, "items": [{"id": "p_1742", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1743", "content": "NE [SEP] hydroxylase knockout (Dbh -/-) mice, which lack norepinephrine (NE), in the elevated plus maze (EPM) to examine the contribution o", "tokenized_content": [2, 2069, 3, 16324, 7949, 12, 6594, 1023, 17, 19, 17, 13, 2518, 16, 2154, 3630, 16436, 12, 2069, 13, 16, 1922, 1920, 4664, 5390, 14476, 12, 2630, 1035, 13, 1942, 3]}, "items": [{"id": "p_1743", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1744", "content": "disulfiram [SEP] was also attenuated in Dbh +/- mice following administration of disulfiram, a dopamine beta-hydroxylase (DBH) inhibitor. In experiments us", "tokenized_content": [2, 10993, 11979, 1035, 3, 1982, 2222, 8060, 1922, 6594, 1023, 15, 19, 17, 2518, 2894, 4183, 1927, 10993, 11979, 1035, 16, 43, 7964, 4666, 17, 16324, 12, 6594, 1023, 13, 3]}, "items": [{"id": "p_1744", "content": "Disulfiram [SEP] A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly", "score": 1, "type": null, "tokenized_content": [2, 10993, 11979, 1035, 3, 43, 17742, 2010, 10533, 2251, 1966, 1925, 4284, 10641, 2825, 1031, 18, 2176, 1977, 43, 4322, 18037, 10605, 7311, 2469, 5254, 4298, 16, 2308, 7686, 3]}]}
{"query": {"id": "q_1745", "content": "propranolol [SEP]  that pretreatment with the beta-adrenergic receptor antagonist propranolol blocked cocaine-induced anxiety-like behavior in Dbh +/- and wi", "tokenized_content": [2, 21395, 3, 1988, 9111, 1956, 1920, 4666, 17, 13672, 3148, 8151, 21395, 6923, 9045, 17, 2719, 5592, 17, 3189, 3379, 1922, 6594, 1023, 15, 19, 17, 1930, 11980, 3]}, "items": [{"id": "p_1745", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_1746", "content": "prazosin [SEP]  +/- and wild-type C57BL6/J mice, while the alpha(1) antagonist prazosin and the alpha(2) antagonist yohimbine had no effect. CONCLUSION", "tokenized_content": [2, 29041, 5872, 3, 15, 19, 17, 1930, 3576, 17, 2601, 8408, 1016, 19, 52, 2518, 16, 2679, 1920, 4595, 12, 21, 13, 8151, 29041, 5872, 1930, 1920, 4595, 12, 22, 3]}, "items": [{"id": "p_1746", "content": "Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS", "score": 1, "type": null, "tokenized_content": [2, 29041, 5872, 3, 43, 5328, 13672, 4595, 17, 21, 8151, 2251, 1922, 1920, 2311, 1927, 4003, 4574, 31, 5579, 31, 30004, 26493, 31, 6451, 2175, 2009, 2445, 1934, 3]}]}
{"query": {"id": "q_1747", "content": "yohimbine [SEP] le the alpha(1) antagonist prazosin and the alpha(2) antagonist yohimbine had no effect. CONCLUSIONS: These results indicate that noradre", "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 2071, 1920, 4595, 12, 21, 13, 8151, 29041, 5872, 1930, 1920, 4595, 12, 22, 13, 8151, 7419, 7969, 17010, 2053, 2430, 2239, 2495, 18, 4355, 3]}, "items": [{"id": "p_1747", "content": "Yohimbine [SEP] A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECT", "score": 1, "type": null, "tokenized_content": [2, 7419, 7969, 17010, 2053, 3, 43, 4496, 29951, 1956, 4595, 17, 22, 17, 13672, 7472, 2455, 18, 7419, 7969, 17010, 2053, 2258, 2252, 2251, 1966, 43, 15388, 3027, 2479, 1930, 1922, 1920, 2311, 1927, 24311, 1031, 3]}]}
{"query": {"id": "q_1748", "content": "Clonidine [SEP] Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes a", "tokenized_content": [2, 26596, 3, 26596, 1958, 4976, 17, 10506, 19, 15534, 4770, 30, 2890, 18, 11497, 2840, 43, 3]}, "items": [{"id": "p_1748", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_1749", "content": "attention-deficit/hyperactivity disorder [SEP] Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis.", "tokenized_content": [2, 4976, 17, 10506, 19, 15534, 4770, 3, 26596, 1958, 4976, 17, 10506, 19, 15534, 4770, 30, 2890, 18, 11497, 2840, 1930, 5246, 3916, 2333, 18, 3]}, "items": [{"id": "p_1749", "content": "Attention Deficit Disorder with Hyperactivity [SEP] A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattent", "score": 1, "type": null, "tokenized_content": [2, 4976, 10506, 4770, 1956, 15534, 3, 43, 3379, 4770, 14391, 1922, 7238, 1922, 2154, 1920, 4415, 4075, 2032, 6879, 1927, 23130, 13770, 27351, 1939, 3]}]}
{"query": {"id": "q_1750", "content": "clonidine [SEP] OBJECTIVE: To examine the safety and tolerability of clonidine used alone or with methylphenidate in children with attention-d", "tokenized_content": [2, 26596, 3, 4470, 30, 1942, 5020, 1920, 5407, 1930, 17934, 1927, 26596, 2251, 4298, 2014, 1956, 4963, 17616, 21550, 1922, 3069, 1956, 4976, 17, 46, 3]}, "items": [{"id": "p_1750", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_1751", "content": "methylphenidate [SEP] ine the safety and tolerability of clonidine used alone or with methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD", "tokenized_content": [2, 4963, 17616, 21550, 3, 11116, 1920, 5407, 1930, 17934, 1927, 26596, 2251, 4298, 2014, 1956, 4963, 17616, 21550, 1922, 3069, 1956, 4976, 17, 10506, 19, 15534, 4770, 12, 9683, 3]}, "items": [{"id": "p_1751", "content": "Methylphenidate [SEP] A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLE", "score": 1, "type": null, "tokenized_content": [2, 4963, 17616, 21550, 3, 43, 4101, 7580, 2433, 24252, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 4976, 10506, 4770, 1922, 3069, 1930, 1958, 22872, 2456, 3]}]}
{"query": {"id": "q_1752", "content": "attention-deficit/hyperactivity disorder [SEP] f clonidine used alone or with methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD). METHOD: In a 16-week multicenter, double-blind trial, 1", "tokenized_content": [2, 4976, 17, 10506, 19, 15534, 4770, 3, 48, 26596, 2251, 4298, 2014, 1956, 4963, 17616, 21550, 1922, 3069, 1956, 4976, 17, 10506, 19, 15534, 4770, 12, 9683, 13, 18, 2417, 3]}, "items": [{"id": "p_1752", "content": "Attention Deficit Disorder with Hyperactivity [SEP] A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattent", "score": 1, "type": null, "tokenized_content": [2, 4976, 10506, 4770, 1956, 15534, 3, 43, 3379, 4770, 14391, 1922, 7238, 1922, 2154, 1920, 4415, 4075, 2032, 6879, 1927, 23130, 13770, 27351, 1939, 3]}]}
{"query": {"id": "q_1753", "content": "ADHD [SEP] date in children with attention-deficit/hyperactivity disorder (ADHD). METHOD: In a 16-week multicenter, double-blind trial, 122 chi", "tokenized_content": [2, 9683, 3, 5699, 1922, 3069, 1956, 4976, 17, 10506, 19, 15534, 4770, 12, 9683, 13, 18, 2417, 30, 1922, 43, 2641, 17, 2982, 14620, 16, 4825, 17, 7109, 3046, 16, 3]}, "items": [{"id": "p_1753", "content": "Attention Deficit Disorder with Hyperactivity [SEP] A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattent", "score": 1, "type": null, "tokenized_content": [2, 4976, 10506, 4770, 1956, 15534, 3, 43, 3379, 4770, 14391, 1922, 7238, 1922, 2154, 1920, 4415, 4075, 2032, 6879, 1927, 23130, 13770, 27351, 1939, 3]}]}
{"query": {"id": "q_1754", "content": "bradycardia [SEP] diograms and vital signs. RESULTS: There were more incidents of bradycardia in subjects treated with clonidine compared with those not trea", "tokenized_content": [2, 26192, 3, 23652, 28218, 1930, 8970, 6879, 18, 2274, 30, 2276, 1985, 2253, 23564, 1927, 26192, 1922, 3297, 2868, 1956, 26596, 2452, 1956, 2690, 2084, 2171, 1019, 3]}, "items": [{"id": "p_1754", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_1755", "content": "Drowsiness [SEP] but not associated with higher rates of early study withdrawal. Drowsiness was common on clonidine, but generally resolved by 6 to 8 weeks", "tokenized_content": [2, 29247, 6777, 1979, 3, 2308, 2084, 2458, 1956, 2580, 3389, 1927, 3120, 2161, 9594, 18, 29247, 6777, 1979, 1982, 3059, 1990, 26596, 16, 2308, 4933, 8397, 2007, 26, 1942, 28, 3]}, "items": [{"id": "p_1755", "content": "Disorders of Excessive Somnolence [SEP] Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include pr", "score": 1, "type": null, "tokenized_content": [2, 4414, 1927, 9122, 5714, 11873, 15253, 1972, 3, 4414, 4378, 2007, 10694, 29067, 2456, 15895, 1021, 2409, 2791, 26830, 3967, 1988, 2278, 3960, 4328, 7295, 18, 8160, 3951, 2033, 3]}]}
{"query": {"id": "q_1756", "content": "Clonidine [SEP] clonidine, but generally resolved by 6 to 8 weeks. CONCLUSIONS: Clonidine, used alone or with methylphenidate, appears safe and well tole", "tokenized_content": [2, 26596, 3, 26596, 16, 2308, 4933, 8397, 2007, 26, 1942, 28, 3625, 18, 4355, 30, 26596, 16, 2251, 4298, 2014, 1956, 4963, 17616, 21550, 16, 5107, 7672, 1930, 2486, 21930, 3]}, "items": [{"id": "p_1756", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_1757", "content": "drowsiness [SEP] cardia and advise patients about the high likelihood of initial drowsiness.", "tokenized_content": [2, 29247, 6777, 1979, 3, 3215, 1019, 1930, 14683, 1021, 2132, 3001, 1920, 2149, 6772, 1927, 3754, 29247, 6777, 1979, 18, 3]}, "items": [{"id": "p_1757", "content": "Disorders of Excessive Somnolence [SEP] Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include pr", "score": 1, "type": null, "tokenized_content": [2, 4414, 1927, 9122, 5714, 11873, 15253, 1972, 3, 4414, 4378, 2007, 10694, 29067, 2456, 15895, 1021, 2409, 2791, 26830, 3967, 1988, 2278, 3960, 4328, 7295, 18, 8160, 3951, 2033, 3]}]}
{"query": {"id": "q_1758", "content": "Thalidomide [SEP] Thalidomide has limited single-agent activity in relapsed or refractory ind", "tokenized_content": [2, 30184, 3, 30184, 2258, 3892, 2957, 17, 5899, 2455, 1922, 18189, 2014, 10923, 2063, 3]}, "items": [{"id": "p_1758", "content": "Thalidomide [SEP] A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic ef", "score": 1, "type": null, "tokenized_content": [2, 30184, 3, 43, 16057, 7650, 2199, 4911, 19554, 10398, 6373, 1966, 43, 2447, 17, 30434, 4219, 5524, 2057, 25810, 3153, 16, 2308, 19540, 2037, 1920, 10878, 2810, 1942, 18909, 3880, 8485, 3]}]}
{"query": {"id": "q_1759", "content": "non-Hodgkin lymphomas [SEP] imited single-agent activity in relapsed or refractory indolent non-Hodgkin lymphomas: a phase II trial of the Cancer and Leukemia Group B.", "tokenized_content": [2, 2447, 17, 17447, 16827, 3, 2042, 2599, 2957, 17, 5899, 2455, 1922, 18189, 2014, 10923, 18050, 4905, 2447, 17, 17447, 16827, 30, 43, 3193, 2890, 3046, 1927, 1920, 2539, 1930, 3]}, "items": [{"id": "p_1759", "content": "Lymphoma, Non-Hodgkin [SEP] Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to", "score": 1, "type": null, "tokenized_content": [2, 8636, 16, 2447, 17, 17447, 3, 2967, 1927, 43, 2210, 1927, 6558, 3861, 1927, 11751, 2960, 1988, 2129, 2037, 17447, 2573, 16, 3301, 2253, 8538, 1956, 5633, 1942, 3]}]}
{"query": {"id": "q_1760", "content": "Cancer [SEP] ractory indolent non-Hodgkin lymphomas: a phase II trial of the Cancer and Leukemia Group B.", "tokenized_content": [2, 2539, 3, 7195, 27708, 18050, 4905, 2447, 17, 17447, 16827, 30, 43, 3193, 2890, 3046, 1927, 1920, 2539, 1930, 8111, 2210, 44, 18, 3]}, "items": [{"id": "p_1760", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1761", "content": "Leukemia [SEP] olent non-Hodgkin lymphomas: a phase II trial of the Cancer and Leukemia Group B.", "tokenized_content": [2, 8111, 3, 12188, 4905, 2447, 17, 17447, 16827, 30, 43, 3193, 2890, 3046, 1927, 1920, 2539, 1930, 8111, 2210, 44, 18, 3]}, "items": [{"id": "p_1761", "content": "Leukemia [SEP] A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukoc", "score": 1, "type": null, "tokenized_content": [2, 8111, 3, 43, 7529, 16, 6558, 2573, 1927, 1920, 2877, 17, 7402, 7393, 16, 4378, 2007, 22797, 4031, 1930, 2740, 1927, 5104, 1994, 3]}]}
{"query": {"id": "q_1762", "content": "Thalidomide [SEP] Thalidomide is an immunomodulatory agent with demonstrated activity in mult", "tokenized_content": [2, 30184, 3, 30184, 1977, 1925, 18659, 5899, 1956, 3161, 2455, 1922, 2556, 1031, 3]}, "items": [{"id": "p_1762", "content": "Thalidomide [SEP] A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic ef", "score": 1, "type": null, "tokenized_content": [2, 30184, 3, 43, 16057, 7650, 2199, 4911, 19554, 10398, 6373, 1966, 43, 2447, 17, 30434, 4219, 5524, 2057, 25810, 3153, 16, 2308, 19540, 2037, 1920, 10878, 2810, 1942, 18909, 3880, 8485, 3]}]}
{"query": {"id": "q_1763", "content": "multiple myeloma [SEP] mide is an immunomodulatory agent with demonstrated activity in multiple myeloma, mantle cell lymphoma and lymphoplasmacytic lymphoma. Its activ", "tokenized_content": [2, 3137, 14471, 3, 3953, 1021, 1977, 1925, 18659, 5899, 1956, 3161, 2455, 1922, 3137, 14471, 16, 25055, 2024, 8636, 1930, 3541, 15851, 27932, 1935, 8636, 18, 2496, 2196, 3]}, "items": [{"id": "p_1763", "content": "Multiple Myeloma [SEP] A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, ", "score": 1, "type": null, "tokenized_content": [2, 3137, 14471, 3, 43, 10248, 1927, 6665, 3582, 2094, 15888, 1922, 7172, 11837, 3372, 18, 2176, 1977, 4378, 2007, 11602, 6012, 17909, 3701, 6026, 16, 3]}]}
{"query": {"id": "q_1764", "content": "mantle cell lymphoma [SEP] odulatory agent with demonstrated activity in multiple myeloma, mantle cell lymphoma and lymphoplasmacytic lymphoma. Its activity is believed to be ", "tokenized_content": [2, 25055, 2024, 8636, 3, 4426, 7795, 5899, 1956, 3161, 2455, 1922, 3137, 14471, 16, 25055, 2024, 8636, 1930, 3541, 15851, 27932, 1935, 8636, 18, 2496, 2455, 1977, 9283, 1942, 1998, 3]}, "items": [{"id": "p_1764", "content": "Lymphoma, Mantle-Cell [SEP] A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. ", "score": 1, "type": null, "tokenized_content": [2, 8636, 16, 25055, 17, 2024, 3, 43, 2386, 1927, 2447, 17, 17447, 8636, 4537, 43, 5394, 9435, 3114, 1956, 2321, 2858, 1930, 3649, 7257, 1930, 2858, 10246, 2094, 18, 3]}]}
{"query": {"id": "q_1765", "content": "lymphoplasmacytic lymphoma [SEP] nstrated activity in multiple myeloma, mantle cell lymphoma and lymphoplasmacytic lymphoma. Its activity is believed to be due modulation of the tumour mi", "tokenized_content": [2, 3541, 15851, 27932, 1935, 8636, 3, 4246, 25957, 2455, 1922, 3137, 14471, 16, 25055, 2024, 8636, 1930, 3541, 15851, 27932, 1935, 8636, 18, 2496, 2455, 1977, 9283, 1942, 1998, 2810, 3]}, "items": [{"id": "p_1765", "content": "Lymphoma [SEP] A general term for various neoplastic diseases of the lymphoid tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8636, 3, 43, 3335, 2576, 1958, 3425, 12847, 3902, 1927, 1920, 11751, 2960, 18, 3]}]}
{"query": {"id": "q_1766", "content": "tumour [SEP]  lymphoma. Its activity is believed to be due modulation of the tumour milieu, including downregulation of angiogenesis and inflammato", "tokenized_content": [2, 6383, 3, 8636, 18, 2496, 2455, 1977, 9283, 1942, 1998, 2810, 7145, 1927, 1920, 6383, 19821, 16, 2710, 9894, 1927, 8244, 1930, 3121, 8286, 3]}, "items": [{"id": "p_1766", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1767", "content": "lymphomas [SEP] 1 and April 2004, 24 patients with relapsed/refractory indolent lymphomas received thalidomide 200 mg daily with escalation by 100 mg dai", "tokenized_content": [2, 16827, 3, 21, 1930, 11071, 4247, 16, 2686, 2132, 1956, 18189, 19, 10923, 18050, 4905, 16827, 4004, 30184, 2191, 2786, 4692, 1956, 20720, 2007, 2813, 2786, 23708, 3]}, "items": [{"id": "p_1767", "content": "Lymphoma [SEP] A general term for various neoplastic diseases of the lymphoid tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8636, 3, 43, 3335, 2576, 1958, 3425, 12847, 3902, 1927, 1920, 11751, 2960, 18, 3]}]}
{"query": {"id": "q_1768", "content": "thalidomide [SEP] 4 patients with relapsed/refractory indolent lymphomas received thalidomide 200 mg daily with escalation by 100 mg daily every 1-2 weeks as", "tokenized_content": [2, 30184, 3, 24, 2132, 1956, 18189, 19, 10923, 18050, 4905, 16827, 4004, 30184, 2191, 2786, 4692, 1956, 20720, 2007, 2813, 2786, 4692, 4808, 21, 17, 22, 3625, 1966, 3]}, "items": [{"id": "p_1768", "content": "Thalidomide [SEP] A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic ef", "score": 1, "type": null, "tokenized_content": [2, 30184, 3, 43, 16057, 7650, 2199, 4911, 19554, 10398, 6373, 1966, 43, 2447, 17, 30434, 4219, 5524, 2057, 25810, 3153, 16, 2308, 19540, 2037, 1920, 10878, 2810, 1942, 18909, 3880, 8485, 3]}]}
{"query": {"id": "q_1769", "content": "myelosuppression [SEP] s progressed during therapy. Grade 3-4 adverse effects included myelosuppression, fatigue, somnolence/depressed mood, neuropathy and dyspnea. Of", "tokenized_content": [2, 5707, 1951, 3481, 3124, 3, 61, 15942, 2409, 3181, 18, 4927, 23, 17, 24, 5246, 2564, 3063, 5707, 1951, 3481, 3124, 16, 8656, 16, 5714, 11873, 15253, 1972, 19, 11365, 3]}, "items": [{"id": "p_1769", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_1770", "content": "fatigue [SEP] g therapy. Grade 3-4 adverse effects included myelosuppression, fatigue, somnolence/depressed mood, neuropathy and dyspnea. Of concern ", "tokenized_content": [2, 8656, 3, 49, 3181, 18, 4927, 23, 17, 24, 5246, 2564, 3063, 5707, 1951, 3481, 3124, 16, 8656, 16, 5714, 11873, 15253, 1972, 19, 11365, 9494, 16, 13177, 1930, 18461, 3]}, "items": [{"id": "p_1770", "content": "Fatigue [SEP] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and re", "score": 1, "type": null, "tokenized_content": [2, 8656, 3, 1920, 3360, 1927, 12615, 8254, 2894, 43, 3047, 1927, 28187, 16, 5018, 2014, 3841, 16, 4378, 2007, 43, 3261, 4796, 1958, 2778, 1930, 1964, 3]}]}
{"query": {"id": "q_1771", "content": "somnolence [SEP] . Grade 3-4 adverse effects included myelosuppression, fatigue, somnolence/depressed mood, neuropathy and dyspnea. Of concern was the occu", "tokenized_content": [2, 5714, 11873, 15253, 1972, 3, 18, 4927, 23, 17, 24, 5246, 2564, 3063, 5707, 1951, 3481, 3124, 16, 8656, 16, 5714, 11873, 15253, 1972, 19, 11365, 9494, 16, 13177, 1930, 3]}, "items": [{"id": "p_1771", "content": "Disorders of Excessive Somnolence [SEP] Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include pr", "score": 1, "type": null, "tokenized_content": [2, 4414, 1927, 9122, 5714, 11873, 15253, 1972, 3, 4414, 4378, 2007, 10694, 29067, 2456, 15895, 1021, 2409, 2791, 26830, 3967, 1988, 2278, 3960, 4328, 7295, 18, 8160, 3951, 2033, 3]}]}
{"query": {"id": "q_1772", "content": "depressed mood [SEP]  adverse effects included myelosuppression, fatigue, somnolence/depressed mood, neuropathy and dyspnea. Of concern was the occurrence of four ", "tokenized_content": [2, 11365, 9494, 3, 5246, 2564, 3063, 5707, 1951, 3481, 3124, 16, 8656, 16, 5714, 11873, 15253, 1972, 19, 11365, 9494, 16, 13177, 1930, 18461, 18, 1927, 8353, 1982, 1920, 6564, 3]}, "items": [{"id": "p_1772", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_1773", "content": "neuropathy [SEP]  included myelosuppression, fatigue, somnolence/depressed mood, neuropathy and dyspnea. Of concern was the occurrence of four thromboembol", "tokenized_content": [2, 13177, 3, 3063, 5707, 1951, 3481, 3124, 16, 8656, 16, 5714, 11873, 15253, 1972, 19, 11365, 9494, 16, 13177, 1930, 18461, 18, 1927, 8353, 1982, 1920, 6564, 1927, 3006, 17361, 3]}, "items": [{"id": "p_1773", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_1774", "content": "dyspnea [SEP] suppression, fatigue, somnolence/depressed mood, neuropathy and dyspnea. Of concern was the occurrence of four thromboembolic events. O", "tokenized_content": [2, 18461, 3, 6412, 16, 8656, 16, 5714, 11873, 15253, 1972, 19, 11365, 9494, 16, 13177, 1930, 18461, 18, 1927, 8353, 1982, 1920, 6564, 1927, 3006, 25580, 3916, 18, 57, 3]}, "items": [{"id": "p_1774", "content": "Dyspnea [SEP] Difficult or labored breathing.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18461, 3, 4571, 2014, 3876, 1919, 11995, 18, 3]}]}
{"query": {"id": "q_1775", "content": "thromboembolic [SEP] , neuropathy and dyspnea. Of concern was the occurrence of four thromboembolic events. Our results failed to demonstrate an important response", "tokenized_content": [2, 25580, 3, 16, 13177, 1930, 18461, 18, 1927, 8353, 1982, 1920, 6564, 1927, 3006, 25580, 3916, 18, 2342, 2274, 6617, 1942, 4504, 1925, 2715, 2644, 3]}, "items": [{"id": "p_1775", "content": "Thromboembolism [SEP] Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23821, 3, 10849, 1927, 43, 2877, 8072, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_1776", "content": "lenalidomide [SEP] vel reported with the second generation immunomodulatory agent, lenalidomide.", "tokenized_content": [2, 29944, 3, 6217, 2568, 1956, 1920, 2812, 4841, 18659, 5899, 16, 29944, 18, 3]}, "items": [{"id": "p_1776", "content": "lenalidomide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29944, 3, 3]}]}
{"query": {"id": "q_1777", "content": "epinephrine [SEP] Intracavernous epinephrine: a minimally invasive treatment for priapism in the emergency d", "tokenized_content": [2, 19280, 3, 4245, 14666, 11873, 1957, 19280, 30, 43, 13019, 6044, 2311, 1958, 17618, 2026, 2421, 1922, 1920, 7877, 46, 3]}, "items": [{"id": "p_1777", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_1778", "content": "priapism [SEP] Intracavernous epinephrine: a minimally invasive treatment for priapism in the emergency department.", "tokenized_content": [2, 17618, 2026, 2421, 3, 4245, 14666, 11873, 1957, 19280, 30, 43, 13019, 6044, 2311, 1958, 17618, 2026, 2421, 1922, 1920, 7877, 6143, 18, 3]}, "items": [{"id": "p_1778", "content": "Priapism [SEP] A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE", "score": 1, "type": null, "tokenized_content": [2, 17618, 2026, 2421, 3, 43, 7171, 15806, 24311, 1929, 1988, 2278, 4691, 1036, 3967, 1930, 1977, 2084, 2458, 1956, 5702, 2455, 18, 2176, 1977, 3945, 1922, 2132, 1956, 21414, 3]}]}
{"query": {"id": "q_1779", "content": "Priapism [SEP] Priapism is the prolonged erection of the penis in the absence of sexual", "tokenized_content": [2, 17618, 2026, 2421, 3, 17618, 2026, 2421, 1977, 1920, 7171, 24311, 1929, 1927, 1920, 29918, 1922, 1920, 3905, 1927, 5702, 3]}, "items": [{"id": "p_1779", "content": "Priapism [SEP] A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE", "score": 1, "type": null, "tokenized_content": [2, 17618, 2026, 2421, 3, 43, 7171, 15806, 24311, 1929, 1988, 2278, 4691, 1036, 3967, 1930, 1977, 2084, 2458, 1956, 5702, 2455, 18, 2176, 1977, 3945, 1922, 2132, 1956, 21414, 3]}]}
{"query": {"id": "q_1780", "content": "cocaine [SEP] ence of sexual arousal. A 45-year-old man, an admitted frequent cocaine user, presented to the Emergency Department (ED) on two separat", "tokenized_content": [2, 9045, 3, 3350, 1021, 1927, 5702, 14216, 18, 43, 3607, 17, 2476, 17, 4156, 2323, 16, 1925, 9723, 6439, 9045, 8124, 16, 3549, 1942, 1920, 7877, 6143, 12, 3347, 13, 3]}, "items": [{"id": "p_1780", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_1781", "content": "priapism [SEP] ncy Department (ED) on two separate occasions with a history of priapism after cocaine use. The management options in the ED, as exempli", "tokenized_content": [2, 17618, 2026, 2421, 3, 5301, 1012, 6143, 12, 3347, 13, 1990, 2288, 5850, 18513, 1956, 43, 4403, 1927, 17618, 2026, 2421, 2256, 9045, 2485, 18, 1920, 4280, 8416, 1922, 1920, 3]}, "items": [{"id": "p_1781", "content": "Priapism [SEP] A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE", "score": 1, "type": null, "tokenized_content": [2, 17618, 2026, 2421, 3, 43, 7171, 15806, 24311, 1929, 1988, 2278, 4691, 1036, 3967, 1930, 1977, 2084, 2458, 1956, 5702, 2455, 18, 2176, 1977, 3945, 1922, 2132, 1956, 21414, 3]}]}
{"query": {"id": "q_1782", "content": "epinephrine [SEP] ticular the use of a minimally invasive method of intracorporal epinephrine instillation, are discussed.", "tokenized_content": [2, 19280, 3, 18298, 2168, 1920, 2485, 1927, 43, 13019, 6044, 2417, 1927, 4245, 12157, 6277, 19280, 24893, 16, 2032, 5601, 18, 3]}, "items": [{"id": "p_1782", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_1783", "content": "green tea [SEP] Effect of green tea and vitamin E combination in isoproterenol induced myocardial i", "tokenized_content": [2, 4524, 12459, 3, 2495, 1927, 4524, 12459, 1930, 6111, 47, 3921, 1922, 23743, 2719, 6497, 51, 3]}, "items": [{"id": "p_1783", "content": "Plant Extracts [SEP] Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is ev", "score": 1, "type": null, "tokenized_content": [2, 4496, 6391, 3, 9421, 11106, 9815, 1927, 4793, 2926, 2007, 11340, 3500, 14423, 1956, 43, 6947, 7596, 16, 2154, 1977, 2180, 3]}]}
{"query": {"id": "q_1784", "content": "vitamin E [SEP] Effect of green tea and vitamin E combination in isoproterenol induced myocardial infarction in r", "tokenized_content": [2, 6111, 47, 3, 2495, 1927, 4524, 12459, 1930, 6111, 47, 3921, 1922, 23743, 2719, 6497, 8358, 1922, 60, 3]}, "items": [{"id": "p_1784", "content": "Vitamin E [SEP] A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydr", "score": 1, "type": null, "tokenized_content": [2, 6111, 47, 3, 43, 13459, 5690, 2684, 1958, 2136, 21432, 1036, 1930, 21682, 18935, 9356, 1036, 1988, 5987, 4595, 17, 21432, 2455, 18, 2007, 25130, 1927, 1920, 14223, 9698, 3]}]}
{"query": {"id": "q_1785", "content": "isoproterenol [SEP] Effect of green tea and vitamin E combination in isoproterenol induced myocardial infarction in rats.", "tokenized_content": [2, 23743, 3, 2495, 1927, 4524, 12459, 1930, 6111, 47, 3921, 1922, 23743, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_1785", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_1786", "content": "myocardial infarction [SEP] of green tea and vitamin E combination in isoproterenol induced myocardial infarction in rats.", "tokenized_content": [2, 6497, 8358, 3, 1927, 4524, 12459, 1930, 6111, 47, 3921, 1922, 23743, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_1786", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_1787", "content": "green tea [SEP]  present study was aimed to investigate the combined effects of green tea and vitamin E on heart weight, body weight, serum marker enzyme", "tokenized_content": [2, 4524, 12459, 3, 2481, 2161, 1982, 6822, 1942, 4482, 1920, 4252, 2564, 1927, 4524, 12459, 1930, 6111, 47, 1990, 4003, 3388, 16, 3362, 3388, 16, 3256, 4966, 4113, 3]}, "items": [{"id": "p_1787", "content": "Plant Extracts [SEP] Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is ev", "score": 1, "type": null, "tokenized_content": [2, 4496, 6391, 3, 9421, 11106, 9815, 1927, 4793, 2926, 2007, 11340, 3500, 14423, 1956, 43, 6947, 7596, 16, 2154, 1977, 2180, 3]}]}
{"query": {"id": "q_1788", "content": "vitamin E [SEP]  was aimed to investigate the combined effects of green tea and vitamin E on heart weight, body weight, serum marker enzymes, lipid perox", "tokenized_content": [2, 6111, 47, 3, 1982, 6822, 1942, 4482, 1920, 4252, 2564, 1927, 4524, 12459, 1930, 6111, 47, 1990, 4003, 3388, 16, 3362, 3388, 16, 3256, 4966, 5038, 16, 4486, 11456, 3]}, "items": [{"id": "p_1788", "content": "Vitamin E [SEP] A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydr", "score": 1, "type": null, "tokenized_content": [2, 6111, 47, 3, 43, 13459, 5690, 2684, 1958, 2136, 21432, 1036, 1930, 21682, 18935, 9356, 1036, 1988, 5987, 4595, 17, 21432, 2455, 18, 2007, 25130, 1927, 1920, 14223, 9698, 3]}]}
{"query": {"id": "q_1789", "content": "isoproterenol [SEP] xidation, endogenous antioxidants and membrane bound ATPases in isoproterenol (ISO)-induced myocardial infarction in rats. Adult male albino ", "tokenized_content": [2, 23743, 3, 11551, 3825, 1929, 16, 5355, 14651, 1930, 3260, 4124, 28132, 1922, 23743, 12, 4911, 13, 17, 2719, 6497, 8358, 1922, 3615, 18, 4160, 4005, 28734, 3]}, "items": [{"id": "p_1789", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_1790", "content": "ISO [SEP] enous antioxidants and membrane bound ATPases in isoproterenol (ISO)-induced myocardial infarction in rats. Adult male albino rats,", "tokenized_content": [2, 4911, 3, 2066, 2080, 14651, 1930, 3260, 4124, 28132, 1922, 23743, 12, 4911, 13, 17, 2719, 6497, 8358, 1922, 3615, 18, 4160, 4005, 28734, 3615, 16, 3]}, "items": [{"id": "p_1790", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_1791", "content": "myocardial infarction [SEP] dants and membrane bound ATPases in isoproterenol (ISO)-induced myocardial infarction in rats. Adult male albino rats, treated with ISO (200 mg/kg, s", "tokenized_content": [2, 6497, 8358, 3, 11434, 1973, 1930, 3260, 4124, 28132, 1922, 23743, 12, 4911, 13, 17, 2719, 6497, 8358, 1922, 3615, 18, 4160, 4005, 28734, 3615, 16, 2868, 1956, 4911, 12, 3]}, "items": [{"id": "p_1791", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_1792", "content": "Ca [SEP] n of heart weight, serum marker enzymes, lipid peroxidation and Ca+2 ATPase level whereas there was a significant (P<0.05) decreas", "tokenized_content": [2, 2332, 3, 56, 1927, 4003, 3388, 16, 3256, 4966, 5038, 16, 4486, 14214, 1930, 2332, 15, 22, 9444, 2237, 3417, 2276, 1982, 43, 2228, 12, 58, 32, 20, 18, 2914, 3]}, "items": [{"id": "p_1792", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_1793", "content": "Na [SEP] cant (P<0.05) decrease in body weight, endogenous antioxidants, Na+/ K+ ATPase and Mg+2 ATPase levels. Administration of green tea", "tokenized_content": [2, 4049, 3, 19895, 12, 58, 32, 20, 18, 2914, 13, 3714, 1922, 3362, 3388, 16, 5355, 14651, 16, 4049, 15, 19, 53, 15, 9444, 1930, 2786, 15, 22, 9444, 2428, 3]}, "items": [{"id": "p_1793", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_1794", "content": "K [SEP] (P<0.05) decrease in body weight, endogenous antioxidants, Na+/ K+ ATPase and Mg+2 ATPase levels. Administration of green tea (10", "tokenized_content": [2, 53, 3, 12, 58, 32, 20, 18, 2914, 13, 3714, 1922, 3362, 3388, 16, 5355, 14651, 16, 4049, 15, 19, 53, 15, 9444, 1930, 2786, 15, 22, 9444, 2428, 18, 3]}, "items": [{"id": "p_1794", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_1795", "content": "Mg [SEP] ase in body weight, endogenous antioxidants, Na+/ K+ ATPase and Mg+2 ATPase levels. Administration of green tea (100 mg/kg/day, p.", "tokenized_content": [2, 2786, 3, 28826, 1922, 3362, 3388, 16, 5355, 14651, 16, 4049, 15, 19, 53, 15, 9444, 1930, 2786, 15, 22, 9444, 2428, 18, 4183, 1927, 4524, 12459, 12, 2813, 2786, 3]}, "items": [{"id": "p_1795", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_1796", "content": "ocular myasthenia [SEP] Development of ocular myasthenia during pegylated interferon and ribavirin treatment for chronic", "tokenized_content": [2, 10046, 3057, 27618, 8572, 3, 2740, 1927, 10046, 3057, 27618, 8572, 2409, 24208, 10001, 1930, 23635, 2311, 1958, 3724, 3]}, "items": [{"id": "p_1796", "content": "Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai", "score": 1, "type": null, "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 43, 4770, 1927, 15829, 5303, 4378, 2007, 12175, 1927, 13598, 1930, 7345, 7848, 18, 15510, 6554, 8770, 1033, 3]}]}
{"query": {"id": "q_1797", "content": "pegylated interferon [SEP] Development of ocular myasthenia during pegylated interferon and ribavirin treatment for chronic hepatitis C.", "tokenized_content": [2, 24208, 10001, 3, 2740, 1927, 10046, 3057, 27618, 8572, 2409, 24208, 10001, 1930, 23635, 2311, 1958, 3724, 7977, 45, 18, 3]}, "items": [{"id": "p_1797", "content": "peginterferon alfa-2b [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7404, 9185, 2070, 1916, 26131, 17, 5751, 3, 3]}]}
{"query": {"id": "q_1798", "content": "ribavirin [SEP] evelopment of ocular myasthenia during pegylated interferon and ribavirin treatment for chronic hepatitis C.", "tokenized_content": [2, 23635, 3, 2180, 1938, 2011, 2017, 1927, 10046, 3057, 27618, 8572, 2409, 24208, 10001, 1930, 23635, 2311, 1958, 3724, 7977, 45, 18, 3]}, "items": [{"id": "p_1798", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1799", "content": "chronic hepatitis C [SEP] sthenia during pegylated interferon and ribavirin treatment for chronic hepatitis C.", "tokenized_content": [2, 3724, 7977, 45, 3, 1955, 22467, 2126, 2409, 24208, 10001, 1930, 23635, 2311, 1958, 3724, 7977, 45, 18, 3]}, "items": [{"id": "p_1799", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_1800", "content": "diplopia [SEP] A 63-year-old male experienced sudden diplopia after 9 weeks of administration of pegylated interferon (IFN) a", "tokenized_content": [2, 18796, 12105, 3, 43, 4968, 17, 2476, 17, 4156, 4005, 6090, 12446, 18796, 12105, 2256, 29, 3625, 1927, 4183, 1927, 24208, 10001, 12, 4862, 13, 43, 3]}, "items": [{"id": "p_1800", "content": "Diplopia [SEP] A visual symptom in which a single object is perceived by the visual cortex as two objects rather than one. Disorders associated", "score": 1, "type": null, "tokenized_content": [2, 18796, 12105, 3, 43, 3737, 3226, 1922, 2154, 43, 2957, 8032, 1977, 6523, 2007, 1920, 3737, 4997, 1966, 2288, 9423, 4356, 2254, 2340, 18, 4414, 2458, 3]}]}
{"query": {"id": "q_1801", "content": "pegylated interferon (IFN) alpha-2b [SEP]  experienced sudden diplopia after 9 weeks of administration of pegylated interferon (IFN) alpha-2b and ribavirin for chronic hepatitis C (CHC). Ophthalmologic exa", "tokenized_content": [2, 24208, 10001, 12, 4862, 13, 4595, 17, 5751, 3, 6090, 12446, 18796, 12105, 2256, 29, 3625, 1927, 4183, 1927, 24208, 10001, 12, 4862, 13, 4595, 17, 5751, 1930, 23635, 1958, 3]}, "items": [{"id": "p_1801", "content": "peginterferon alfa-2b [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7404, 9185, 2070, 1916, 26131, 17, 5751, 3, 3]}]}
{"query": {"id": "q_1802", "content": "ribavirin [SEP] ks of administration of pegylated interferon (IFN) alpha-2b and ribavirin for chronic hepatitis C (CHC). Ophthalmologic examinations show", "tokenized_content": [2, 23635, 3, 11626, 1927, 4183, 1927, 24208, 10001, 12, 4862, 13, 4595, 17, 5751, 1930, 23635, 1958, 3724, 7977, 45, 12, 25009, 13, 18, 14554, 4467, 10643, 2146, 3]}, "items": [{"id": "p_1802", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1803", "content": "chronic hepatitis C [SEP] ration of pegylated interferon (IFN) alpha-2b and ribavirin for chronic hepatitis C (CHC). Ophthalmologic examinations showed ptosis on the right u", "tokenized_content": [2, 3724, 7977, 45, 3, 12488, 1927, 24208, 10001, 12, 4862, 13, 4595, 17, 5751, 1930, 23635, 1958, 3724, 7977, 45, 12, 25009, 13, 18, 14554, 4467, 10643, 2594, 4401, 2475, 3]}, "items": [{"id": "p_1803", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_1804", "content": "CHC [SEP] nterferon (IFN) alpha-2b and ribavirin for chronic hepatitis C (CHC). Ophthalmologic examinations showed ptosis on the right upper ", "tokenized_content": [2, 25009, 3, 5891, 1915, 2070, 1916, 12, 4862, 13, 4595, 17, 5751, 1930, 23635, 1958, 3724, 7977, 45, 12, 25009, 13, 18, 14554, 4467, 10643, 2594, 4401, 2475, 1990, 1920, 3]}, "items": [{"id": "p_1804", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_1805", "content": "ptosis on the right upper lid [SEP] r chronic hepatitis C (CHC). Ophthalmologic examinations showed ptosis on the right upper lid and restricted right eye movement without any other neurologica", "tokenized_content": [2, 4401, 2475, 1990, 1920, 3659, 5199, 13096, 3, 60, 3724, 7977, 45, 12, 25009, 13, 18, 14554, 4467, 10643, 2594, 4401, 2475, 1990, 1920, 3659, 5199, 13096, 1930, 6715, 3659, 3]}, "items": [{"id": "p_1805", "content": "Blepharoptosis [SEP] Drooping of the upper lid due to deficient development or paralysis of the levator palpebrae muscle.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6189, 4151, 2928, 4575, 8362, 3, 8442, 2011, 1941, 1927, 1920, 5199, 13096, 2810, 1942, 5778, 2740, 2014, 18973, 1927, 1920, 10157, 3061, 15771, 13495, 5524, 1021, 3760, 18, 3]}]}
{"query": {"id": "q_1806", "content": "restricted right eye movement [SEP] almologic examinations showed ptosis on the right upper lid and restricted right eye movement without any other neurological signs. A brain imaging study and", "tokenized_content": [2, 6715, 3659, 5723, 5829, 3, 29709, 4467, 10643, 2594, 4401, 2475, 1990, 1920, 3659, 5199, 13096, 1930, 6715, 3659, 5723, 5829, 2979, 2967, 2303, 7605, 6879, 18, 43, 3068, 3755, 3]}, "items": [{"id": "p_1806", "content": "Ocular Motility Disorders [SEP] Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into i", "score": 1, "type": null, "tokenized_content": [2, 10046, 9254, 4414, 3, 4414, 1988, 5961, 6159, 1927, 5723, 8264, 1966, 43, 3065, 15570, 1927, 2573, 18, 2144, 2961, 2278, 1998, 5831, 2460, 51, 3]}]}
{"query": {"id": "q_1807", "content": "acetylcholine [SEP] repetitive nerve stimulation test indicated no abnormality. The acetylcholine receptor antibody titer and response to acetylcholinesterase in", "tokenized_content": [2, 14561, 3, 12089, 5507, 4177, 2648, 3391, 2239, 14311, 18, 1920, 14561, 3148, 3533, 13036, 1930, 2644, 1942, 30003, 1922, 3]}, "items": [{"id": "p_1807", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_1808", "content": "pegylated IFN alpha-2b [SEP] ical symptoms improved rapidly 3 weeks after discontinuation of pegylated IFN alpha-2b and ribavirin. The ocular myasthenia associated with combinatio", "tokenized_content": [2, 24208, 4862, 4595, 17, 5751, 3, 14784, 1024, 3601, 4305, 6221, 23, 3625, 2256, 14775, 1927, 24208, 4862, 4595, 17, 5751, 1930, 23635, 18, 1920, 10046, 3057, 27618, 8572, 2458, 3]}, "items": [{"id": "p_1808", "content": "peginterferon alfa-2b [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7404, 9185, 2070, 1916, 26131, 17, 5751, 3, 3]}]}
{"query": {"id": "q_1809", "content": "ocular myasthenia [SEP] er discontinuation of pegylated IFN alpha-2b and ribavirin. The ocular myasthenia associated with combination therapy of pegylated IFN alpha-2b a", "tokenized_content": [2, 10046, 3057, 27618, 8572, 3, 2668, 14775, 1927, 24208, 4862, 4595, 17, 5751, 1930, 23635, 18, 1920, 10046, 3057, 27618, 8572, 2458, 1956, 3921, 3181, 1927, 24208, 4862, 4595, 17, 3]}, "items": [{"id": "p_1809", "content": "Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai", "score": 1, "type": null, "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 43, 4770, 1927, 15829, 5303, 4378, 2007, 12175, 1927, 13598, 1930, 7345, 7848, 18, 15510, 6554, 8770, 1033, 3]}]}
{"query": {"id": "q_1810", "content": "IFN [SEP] plopia after 9 weeks of administration of pegylated interferon (IFN) alpha-2b and ribavirin for chronic hepatitis C (CHC). Ophthalm", "tokenized_content": [2, 4862, 3, 2123, 12105, 2256, 29, 3625, 1927, 4183, 1927, 24208, 10001, 12, 4862, 13, 4595, 17, 5751, 1930, 23635, 1958, 3724, 7977, 45, 12, 25009, 13, 18, 14554, 3]}, "items": [{"id": "p_1810", "content": "peginterferon alfa-2b [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7404, 9185, 2070, 1916, 26131, 17, 5751, 3, 3]}]}
{"query": {"id": "q_1811", "content": "glycine [SEP] The glycine transporter-1 inhibitor SSR103800 displays a selective and spec", "tokenized_content": [2, 10646, 3, 1920, 10646, 9054, 17, 21, 4106, 19314, 14726, 26749, 10750, 43, 5328, 1930, 2187, 3]}, "items": [{"id": "p_1811", "content": "Glycine [SEP] A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also", "score": 1, "type": null, "tokenized_content": [2, 10646, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 2176, 1977, 2435, 5985, 1922, 13200, 1930, 16947, 5094, 1921, 1930, 2251, 25058, 1966, 43, 8708, 18, 2176, 1977, 2222, 3]}]}
{"query": {"id": "q_1812", "content": "Schizophrenia [SEP] Schizophrenia has been initially associated with dysfunction in dopamine neur", "tokenized_content": [2, 7899, 3, 7899, 2258, 2252, 6370, 2458, 1956, 5273, 1922, 7964, 2974, 3]}, "items": [{"id": "p_1812", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_1813", "content": "dopamine [SEP] Schizophrenia has been initially associated with dysfunction in dopamine neurotransmission. However, the observation that antagonists of", "tokenized_content": [2, 7964, 3, 7899, 2258, 2252, 6370, 2458, 1956, 5273, 1922, 7964, 20221, 18, 2406, 16, 1920, 5275, 1988, 10515, 1927, 3]}, "items": [{"id": "p_1813", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1814", "content": "glutamate [SEP] otransmission. However, the observation that antagonists of the glutamate N-methyl-D-aspartate (NMDA) receptor produce schizophrenic-like", "tokenized_content": [2, 7627, 3, 7608, 17182, 18538, 3397, 18, 2406, 16, 1920, 5275, 1988, 10515, 1927, 1920, 7627, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 5074, 28247, 17, 3]}, "items": [{"id": "p_1814", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_1815", "content": "N-methyl-D-aspartate [SEP] ion. However, the observation that antagonists of the glutamate N-methyl-D-aspartate (NMDA) receptor produce schizophrenic-like symptoms in humans h", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 4755, 18, 2406, 16, 1920, 5275, 1988, 10515, 1927, 1920, 7627, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 3]}, "items": [{"id": "p_1815", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_1816", "content": "NMDA [SEP] rvation that antagonists of the glutamate N-methyl-D-aspartate (NMDA) receptor produce schizophrenic-like symptoms in humans has led", "tokenized_content": [2, 10976, 3, 8309, 1943, 1988, 10515, 1927, 1920, 7627, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 5074, 28247, 17, 3189, 3601, 1922, 5209, 2258, 4866, 3]}, "items": [{"id": "p_1816", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_1817", "content": "schizophrenic [SEP] s of the glutamate N-methyl-D-aspartate (NMDA) receptor produce schizophrenic-like symptoms in humans has led to the idea of a dysfunctioning", "tokenized_content": [2, 28247, 3, 61, 1927, 1920, 7627, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 5074, 28247, 17, 3189, 3601, 1922, 5209, 2258, 4866, 1942, 1920, 8551, 1927, 3]}, "items": [{"id": "p_1817", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_1818", "content": "glycine [SEP] ic system via a modulation of the NMDA receptor. Among them are glycine transporter-1 (GlyT1) inhibitors such as SSR103800, which indir", "tokenized_content": [2, 10646, 3, 3996, 2433, 3454, 43, 7145, 1927, 1920, 10976, 3148, 18, 2706, 3581, 2032, 10646, 9054, 17, 21, 12, 3376, 6613, 13, 4472, 2427, 1966, 19314, 14726, 26749, 16, 3]}, "items": [{"id": "p_1818", "content": "Glycine [SEP] A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also", "score": 1, "type": null, "tokenized_content": [2, 10646, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 2176, 1977, 2435, 5985, 1922, 13200, 1930, 16947, 5094, 1921, 1930, 2251, 25058, 1966, 43, 8708, 18, 2176, 1977, 2222, 3]}]}
{"query": {"id": "q_1819", "content": "hyperactivity [SEP] e properties of SSR103800, with a particular focus on models of hyperactivity, involving either drug challenge (ie, amphetamine and MK-801) o", "tokenized_content": [2, 15534, 3, 47, 3879, 1927, 19314, 14726, 26749, 16, 1956, 43, 3278, 3691, 1990, 3130, 1927, 15534, 16, 5884, 3108, 2838, 6013, 12, 10116, 16, 19057, 1930, 10539, 17, 23858, 3]}, "items": [{"id": "p_1819", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1820", "content": "amphetamine [SEP] n models of hyperactivity, involving either drug challenge (ie, amphetamine and MK-801) or transgenic mice (ie, NMDA Nr1(neo-/-) and DAT(-/", "tokenized_content": [2, 19057, 3, 56, 3130, 1927, 15534, 16, 5884, 3108, 2838, 6013, 12, 10116, 16, 19057, 1930, 10539, 17, 23858, 13, 2014, 6309, 2518, 12, 10116, 16, 10976, 25898, 12, 11724, 3]}, "items": [{"id": "p_1820", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_1821", "content": "MK-801 [SEP] ractivity, involving either drug challenge (ie, amphetamine and MK-801) or transgenic mice (ie, NMDA Nr1(neo-/-) and DAT(-/-)). Result", "tokenized_content": [2, 10539, 17, 23858, 3, 7195, 8158, 16, 5884, 3108, 2838, 6013, 12, 10116, 16, 19057, 1930, 10539, 17, 23858, 13, 2014, 6309, 2518, 12, 10116, 16, 10976, 25898, 12, 11724, 3]}, "items": [{"id": "p_1821", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_1822", "content": "haloperidol [SEP]  knockout mice (10-30 mg/kg p.o.). Importantly, both classical (haloperidol) and atypical (olanzapine, clozapine and aripiprazole) antipsyc", "tokenized_content": [2, 25107, 3, 7949, 2518, 12, 2119, 17, 2627, 2786, 19, 3621, 58, 18, 57, 18, 13, 18, 6444, 16, 2321, 8445, 12, 25107, 13, 1930, 10834, 12, 26591, 16, 24424, 3]}, "items": [{"id": "p_1822", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_1823", "content": "olanzapine [SEP]  p.o.). Importantly, both classical (haloperidol) and atypical (olanzapine, clozapine and aripiprazole) antipsychotics were effective in a", "tokenized_content": [2, 26591, 3, 58, 18, 57, 18, 13, 18, 6444, 16, 2321, 8445, 12, 25107, 13, 1930, 10834, 12, 26591, 16, 24424, 1930, 27950, 10984, 26252, 13, 21474, 1985, 3655, 1922, 3]}, "items": [{"id": "p_1823", "content": "olanzapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26591, 3, 3]}]}
{"query": {"id": "q_1824", "content": "clozapine [SEP] rtantly, both classical (haloperidol) and atypical (olanzapine, clozapine and aripiprazole) antipsychotics were effective in all these mo", "tokenized_content": [2, 24424, 3, 25551, 4905, 1954, 16, 2321, 8445, 12, 25107, 13, 1930, 10834, 12, 26591, 16, 24424, 1930, 27950, 10984, 26252, 13, 21474, 1985, 3655, 1922, 2136, 2144, 2661, 3]}, "items": [{"id": "p_1824", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_1825", "content": "aripiprazole [SEP] classical (haloperidol) and atypical (olanzapine, clozapine and aripiprazole) antipsychotics were effective in all these models of hyperacti", "tokenized_content": [2, 27950, 10984, 26252, 3, 8445, 12, 25107, 13, 1930, 10834, 12, 26591, 16, 24424, 1930, 27950, 10984, 26252, 13, 21474, 1985, 3655, 1922, 2136, 2144, 3130, 1927, 4194, 2131, 1033, 3]}, "items": [{"id": "p_1825", "content": "aripiprazole [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 27950, 10984, 26252, 3, 3]}]}
{"query": {"id": "q_1826", "content": "catalepsy [SEP] tivity. However, unlike these latter, SSR103800 did not produce catalepsy (retention on the bar test) up to 30 mg/kg p.o. Together these ", "tokenized_content": [2, 4233, 9431, 1012, 3, 8685, 3273, 18, 2406, 16, 7945, 2144, 6296, 16, 19314, 14726, 26749, 2811, 2084, 5074, 4233, 9431, 1012, 12, 7521, 1990, 1920, 3241, 2648, 13, 2353, 3]}, "items": [{"id": "p_1826", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_1827", "content": "Phenylephrine [SEP] Phenylephrine but not ephedrine reduces frontal lobe oxygenation following an", "tokenized_content": [2, 27053, 3, 27053, 2308, 2084, 12717, 1919, 5773, 7268, 8086, 9581, 16529, 2894, 1925, 3]}, "items": [{"id": "p_1827", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_1828", "content": "ephedrine [SEP] Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced h", "tokenized_content": [2, 12717, 1919, 5773, 3, 27053, 2308, 2084, 12717, 1919, 5773, 7268, 8086, 9581, 16529, 2894, 8871, 17, 2719, 50, 3]}, "items": [{"id": "p_1828", "content": "Ephedrine [SEP] A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may als", "score": 1, "type": null, "tokenized_content": [2, 12717, 1919, 5773, 3, 43, 3037, 5188, 3812, 2435, 1922, 12717, 1919, 5524, 3132, 6102, 18, 11520, 2128, 13521, 5773, 1977, 1925, 15348, 18, 2176, 1977, 1925, 4595, 17, 1930, 4666, 17, 13672, 7829, 1988, 2278, 10534, 3]}]}
{"query": {"id": "q_1829", "content": "reduces frontal lobe oxygenation [SEP] Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension.", "tokenized_content": [2, 7268, 8086, 9581, 16529, 3, 27053, 2308, 2084, 12717, 1919, 5773, 7268, 8086, 9581, 16529, 2894, 8871, 17, 2719, 16453, 18, 3]}, "items": [{"id": "p_1829", "content": "Hypoxia, Brain [SEP] A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to ", "score": 1, "type": null, "tokenized_content": [2, 7264, 16, 3068, 3, 43, 3378, 1922, 3068, 4612, 9042, 2810, 1942, 28976, 1039, 3847, 12, 43, 3028, 4351, 1927, 4612, 3301, 4371, 1922, 1920, 2877, 2007, 9652, 13, 16, 2014, 1942, 3]}]}
{"query": {"id": "q_1830", "content": "hypotension [SEP] e reduces frontal lobe oxygenation following anesthesia-induced hypotension.", "tokenized_content": [2, 16453, 3, 47, 7268, 8086, 9581, 16529, 2894, 8871, 17, 2719, 16453, 18, 3]}, "items": [{"id": "p_1830", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1831", "content": "hypotension [SEP] OUND: Vasopressor agents are used to correct anesthesia-induced hypotension. We describe the effect of phenylephrine and ephedrine on front", "tokenized_content": [2, 16453, 3, 17208, 10249, 30, 17598, 1924, 4820, 2032, 2251, 1942, 5550, 8871, 17, 2719, 16453, 18, 2038, 5993, 1920, 2495, 1927, 27053, 1930, 12717, 1919, 5773, 1990, 9144, 3]}, "items": [{"id": "p_1831", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1832", "content": "phenylephrine [SEP] rrect anesthesia-induced hypotension. We describe the effect of phenylephrine and ephedrine on frontal lobe oxygenation (S(c)O(2)) following ", "tokenized_content": [2, 27053, 3, 5162, 2089, 8871, 17, 2719, 16453, 18, 2038, 5993, 1920, 2495, 1927, 27053, 1930, 12717, 1919, 5773, 1990, 8086, 9581, 16529, 12, 61, 12, 45, 13, 57, 12, 3]}, "items": [{"id": "p_1832", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_1833", "content": "ephedrine [SEP] nduced hypotension. We describe the effect of phenylephrine and ephedrine on frontal lobe oxygenation (S(c)O(2)) following anesthesia-ind", "tokenized_content": [2, 12717, 1919, 5773, 3, 8026, 2418, 16453, 18, 2038, 5993, 1920, 2495, 1927, 27053, 1930, 12717, 1919, 5773, 1990, 8086, 9581, 16529, 12, 61, 12, 45, 13, 57, 12, 22, 3]}, "items": [{"id": "p_1833", "content": "Ephedrine [SEP] A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may als", "score": 1, "type": null, "tokenized_content": [2, 12717, 1919, 5773, 3, 43, 3037, 5188, 3812, 2435, 1922, 12717, 1919, 5524, 3132, 6102, 18, 11520, 2128, 13521, 5773, 1977, 1925, 15348, 18, 2176, 1977, 1925, 4595, 17, 1930, 4666, 17, 13672, 7829, 1988, 2278, 10534, 3]}]}
{"query": {"id": "q_1834", "content": "fentanyl [SEP] uced hypotension. METHODS: Following induction of anesthesia by fentanyl (0.15 mg kg(-1)) and propofol (2.0 mg kg(-1)), 13 patients rece", "tokenized_content": [2, 20311, 3, 8577, 1919, 16453, 18, 2860, 30, 2894, 4408, 1927, 8871, 2007, 20311, 12, 20, 18, 2461, 2786, 3621, 12, 17, 21, 13, 13, 1930, 16615, 12, 22, 18, 3]}, "items": [{"id": "p_1834", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_1835", "content": "propofol [SEP] lowing induction of anesthesia by fentanyl (0.15 mg kg(-1)) and propofol (2.0 mg kg(-1)), 13 patients received phenylephrine (0.1 mg iv)", "tokenized_content": [2, 16615, 3, 2330, 1941, 4408, 1927, 8871, 2007, 20311, 12, 20, 18, 2461, 2786, 3621, 12, 17, 21, 13, 13, 1930, 16615, 12, 22, 18, 20, 2786, 3621, 12, 17, 3]}, "items": [{"id": "p_1835", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_1836", "content": "stroke [SEP]  to restore mean arterial pressure (MAP). Heart rate (HR), MAP, stroke volume (SV), cardiac output (CO), and frontal lobe oxygenation ", "tokenized_content": [2, 5235, 3, 1942, 12900, 2667, 6624, 3772, 12, 4446, 13, 18, 4003, 2769, 12, 3668, 13, 16, 4446, 16, 5235, 3776, 12, 6456, 13, 16, 4435, 6647, 12, 2081, 13, 3]}, "items": [{"id": "p_1836", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_1837", "content": "a decrease in MAP [SEP] re registered. RESULTS: Induction of anesthesia was followed by a decrease in MAP, HR, SV, and CO concomitant with an elevation in S(c)O(2). Afte", "tokenized_content": [2, 43, 3714, 1922, 4446, 3, 1964, 10012, 18, 2274, 30, 4408, 1927, 8871, 1982, 3489, 2007, 43, 3714, 1922, 4446, 16, 3668, 16, 6456, 16, 1930, 2081, 8537, 1956, 1925, 3]}, "items": [{"id": "p_1837", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1838", "content": "obsessive-compulsive-like behaviors [SEP] A novel, multiple symptom model of obsessive-compulsive-like behaviors in animals.", "tokenized_content": [2, 25555, 17, 21543, 17, 3189, 5888, 3, 43, 4008, 16, 3137, 3226, 2322, 1927, 25555, 17, 21543, 17, 3189, 5888, 1922, 3555, 18, 3]}, "items": [{"id": "p_1838", "content": "Obsessive-Compulsive Disorder [SEP] An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, though", "score": 1, "type": null, "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 1925, 5592, 4770, 4378, 2007, 7457, 16, 7733, 2339, 6744, 2014, 2059, 19389, 18, 2339, 6744, 2032, 1920, 2738, 7556, 15479, 16, 4170, 3]}]}
{"query": {"id": "q_1839", "content": "obsessive-compulsive disorder [SEP] BACKGROUND: Current animal models of obsessive-compulsive disorder (OCD) typically involve acute, drug-induced symptom provocation", "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 3872, 30, 3214, 4027, 3130, 1927, 25555, 17, 21543, 4770, 12, 18052, 13, 5745, 8156, 3939, 16, 2838, 17, 2719, 3226, 2463, 5980, 3]}, "items": [{"id": "p_1839", "content": "Obsessive-Compulsive Disorder [SEP] An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, though", "score": 1, "type": null, "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 1925, 5592, 4770, 4378, 2007, 7457, 16, 7733, 2339, 6744, 2014, 2059, 19389, 18, 2339, 6744, 2032, 1920, 2738, 7556, 15479, 16, 4170, 3]}]}
{"query": {"id": "q_1840", "content": "OCD [SEP] GROUND: Current animal models of obsessive-compulsive disorder (OCD) typically involve acute, drug-induced symptom provocation or a", "tokenized_content": [2, 18052, 3, 7406, 30, 3214, 4027, 3130, 1927, 25555, 17, 21543, 4770, 12, 18052, 13, 5745, 8156, 3939, 16, 2838, 17, 2719, 3226, 2463, 5980, 2014, 43, 3]}, "items": [{"id": "p_1840", "content": "Obsessive-Compulsive Disorder [SEP] An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, though", "score": 1, "type": null, "tokenized_content": [2, 25555, 17, 21543, 4770, 3, 1925, 5592, 4770, 4378, 2007, 7457, 16, 7733, 2339, 6744, 2014, 2059, 19389, 18, 2339, 6744, 2032, 1920, 2738, 7556, 15479, 16, 4170, 3]}]}
{"query": {"id": "q_1841", "content": "anxiety [SEP] mptom provocation or a genetic association with stereotypies or anxiety. None of these current models demonstrate multiple OCD-like beh", "tokenized_content": [2, 5592, 3, 15840, 1947, 2463, 5980, 2014, 43, 3299, 3279, 1956, 18028, 2085, 2062, 2014, 5592, 18, 6046, 1927, 2144, 3214, 3130, 4504, 3137, 18052, 17, 3189, 9033, 3]}, "items": [{"id": "p_1841", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_1842", "content": "antidepressant [SEP] haviors. METHODS: Neonatal rats were treated with the tricyclic antidepressant clomipramine or vehicle between days 9 and 16 twice daily and b", "tokenized_content": [2, 14183, 3, 25838, 27951, 18, 2860, 30, 7985, 3615, 1985, 2868, 1956, 1920, 12258, 13153, 14183, 12596, 7395, 13399, 25157, 2014, 6463, 2192, 3000, 29, 1930, 2641, 6470, 4692, 1930, 3]}, "items": [{"id": "p_1842", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_1843", "content": "clomipramine [SEP] S: Neonatal rats were treated with the tricyclic antidepressant clomipramine or vehicle between days 9 and 16 twice daily and behaviorally t", "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 61, 30, 7985, 3615, 1985, 2868, 1956, 1920, 12258, 13153, 14183, 12596, 7395, 13399, 25157, 2014, 6463, 2192, 3000, 29, 1930, 2641, 6470, 4692, 1930, 3]}, "items": [{"id": "p_1843", "content": "Clomipramine [SEP] A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily a", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 43, 12258, 13153, 14183, 2551, 1942, 2042, 27085, 1988, 9331, 7042, 1920, 5047, 1927, 11153, 1922, 1920, 3068, 18, 2176, 1977, 8745, 43, 3]}]}
{"query": {"id": "q_1844", "content": "Clomipramine [SEP] d 16 twice daily and behaviorally tested in adulthood. RESULTS: Clomipramine exposure in immature rats produced significant behavioral and b", "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 46, 2641, 6470, 4692, 1930, 5343, 1954, 3620, 1922, 10731, 18, 2274, 30, 12596, 7395, 13399, 25157, 3395, 1922, 11246, 3615, 4152, 2228, 5343, 1930, 3]}, "items": [{"id": "p_1844", "content": "Clomipramine [SEP] A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily a", "score": 1, "type": null, "tokenized_content": [2, 12596, 7395, 13399, 25157, 3, 43, 12258, 13153, 14183, 2551, 1942, 2042, 27085, 1988, 9331, 7042, 1920, 5047, 1927, 11153, 1922, 1920, 3068, 18, 2176, 1977, 8745, 43, 3]}]}
{"query": {"id": "q_1845", "content": "memory impairment [SEP] neous alternation task and impaired reversal learning), working memory impairment (e.g., win-shift paradigm), hoarding, and corticostriatal dysfu", "tokenized_content": [2, 4525, 6159, 3, 11724, 1957, 4070, 1943, 3909, 1930, 5761, 12393, 4809, 13, 16, 5905, 4525, 6159, 12, 47, 18, 49, 18, 16, 14383, 17, 5950, 9930, 13, 16, 6673, 3]}, "items": [{"id": "p_1845", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_1846", "content": "hoarding [SEP] earning), working memory impairment (e.g., win-shift paradigm), hoarding, and corticostriatal dysfunction. Dopamine D2 receptors were el", "tokenized_content": [2, 6673, 4512, 3, 28438, 13, 16, 5905, 4525, 6159, 12, 47, 18, 49, 18, 16, 14383, 17, 5950, 9930, 13, 16, 6673, 4512, 16, 1930, 8106, 17414, 21195, 5273, 18, 3]}, "items": [{"id": "p_1846", "content": "Obsessive Hoarding [SEP] Persistent difficulty discarding or parting with possessions, regardless of the value of these possessions. Epidemiological stud", "score": 1, "type": null, "tokenized_content": [2, 25555, 6673, 4512, 3, 7733, 8791, 2863, 4512, 2014, 27503, 2029, 1956, 7150, 2443, 16, 7447, 1927, 1920, 3113, 1927, 2144, 7150, 2443, 18, 9591, 2060, 3]}]}
{"query": {"id": "q_1847", "content": "Dopamine [SEP] win-shift paradigm), hoarding, and corticostriatal dysfunction. Dopamine D2 receptors were elevated in the striatum, whereas serotonin 2", "tokenized_content": [2, 7964, 3, 14383, 17, 5950, 9930, 13, 16, 6673, 4512, 16, 1930, 8106, 17414, 21195, 5273, 18, 7964, 8631, 4086, 1985, 4664, 1922, 1920, 11259, 16, 3417, 11153, 22, 3]}, "items": [{"id": "p_1847", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1848", "content": "serotonin [SEP] n. Dopamine D2 receptors were elevated in the striatum, whereas serotonin 2C, but not serotonin 1A, receptors were elevated in the orbita", "tokenized_content": [2, 11153, 3, 56, 18, 7964, 8631, 4086, 1985, 4664, 1922, 1920, 11259, 16, 3417, 11153, 6921, 16, 2308, 2084, 11153, 5123, 16, 4086, 1985, 4664, 1922, 1920, 14905, 1019, 3]}, "items": [{"id": "p_1848", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_1849", "content": "psychiatric disorders [SEP] or current and future therapeutic strategies for this and other psychiatric disorders.", "tokenized_content": [2, 7652, 4414, 3, 2014, 3214, 1930, 4115, 4272, 4762, 1958, 2052, 1930, 2303, 7652, 4414, 18, 3]}, "items": [{"id": "p_1849", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_1850", "content": "hemolytic uremic syndrome [SEP] Late recovery of renal function in a woman with the hemolytic uremic syndrome.", "tokenized_content": [2, 21515, 29870, 4741, 3, 5058, 5241, 1927, 4604, 2347, 1922, 43, 10440, 1956, 1920, 21515, 29870, 4741, 18, 3]}, "items": [{"id": "p_1850", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_1851", "content": "hemolytic uremic syndrome [SEP] A case is reported of the hemolytic uremic syndrome (HUS) in a woman taking oral contraceptives. She was treated wi", "tokenized_content": [2, 21515, 29870, 4741, 3, 43, 3087, 1977, 2568, 1927, 1920, 21515, 29870, 4741, 12, 14723, 13, 1922, 43, 10440, 6303, 4726, 25434, 18, 4693, 1982, 2868, 11980, 3]}, "items": [{"id": "p_1851", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_1852", "content": "HUS [SEP] A case is reported of the hemolytic uremic syndrome (HUS) in a woman taking oral contraceptives. She was treated with he", "tokenized_content": [2, 14723, 3, 43, 3087, 1977, 2568, 1927, 1920, 21515, 29870, 4741, 12, 14723, 13, 1922, 43, 10440, 6303, 4726, 25434, 18, 4693, 1982, 2868, 1956, 2234, 3]}, "items": [{"id": "p_1852", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_1853", "content": "oral contraceptives [SEP] ported of the hemolytic uremic syndrome (HUS) in a woman taking oral contraceptives. She was treated with heparin, dipyridamole and hemodialysis; a", "tokenized_content": [2, 4726, 25434, 3, 9260, 1919, 1927, 1920, 21515, 29870, 4741, 12, 14723, 13, 1922, 43, 10440, 6303, 4726, 25434, 18, 4693, 1982, 2868, 1956, 9962, 16, 9137, 3553, 9532, 12492, 3]}, "items": [{"id": "p_1853", "content": "Contraceptives, Oral [SEP] Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are ", "score": 1, "type": null, "tokenized_content": [2, 25434, 16, 4726, 3, 4300, 16, 5394, 12438, 16, 4208, 12950, 1922, 3238, 1942, 3367, 21496, 1930, 4625, 1920, 6564, 1927, 5284, 18, 1920, 10224, 2032, 3]}]}
{"query": {"id": "q_1854", "content": "heparin [SEP] US) in a woman taking oral contraceptives. She was treated with heparin, dipyridamole and hemodialysis; and after more than three month", "tokenized_content": [2, 9962, 3, 2022, 13, 1922, 43, 10440, 6303, 4726, 25434, 18, 4693, 1982, 2868, 1956, 9962, 16, 9137, 3553, 9532, 12492, 1952, 1930, 15932, 31, 1930, 2256, 2253, 2254, 2559, 3]}, "items": [{"id": "p_1854", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_1855", "content": "dipyridamole [SEP] woman taking oral contraceptives. She was treated with heparin, dipyridamole and hemodialysis; and after more than three months, her urinary", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 10440, 6303, 4726, 25434, 18, 4693, 1982, 2868, 1956, 9962, 16, 9137, 3553, 9532, 12492, 1952, 1930, 15932, 31, 1930, 2256, 2253, 2254, 2559, 3]}, "items": [{"id": "p_1855", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_1856", "content": "anuria [SEP] ary output rose above 500 ml; and six months after the onset of anuria, dialysis treatment was stopped. This case emphasizes the possi", "tokenized_content": [2, 1925, 8754, 3, 2245, 1012, 6647, 13679, 3538, 4599, 2646, 31, 1930, 3798, 3221, 2256, 1920, 4727, 1927, 1925, 8754, 16, 9787, 2311, 1982, 12032, 18, 2052, 3087, 19442, 1920, 3]}, "items": [{"id": "p_1856", "content": "Anuria [SEP] Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urina", "score": 1, "type": null, "tokenized_content": [2, 1925, 8754, 3, 3905, 1927, 6960, 3337, 18, 2176, 1977, 5394, 2458, 1956, 4080, 7787, 24820, 12, 15168, 13, 10849, 16, 4080, 2826, 3674, 4058, 3]}]}
{"query": {"id": "q_1857", "content": "oliguria [SEP] ults is not invariably irreversible and that, despite prolonged oliguria, recovery of renal function can be obtained. Therefore, in adul", "tokenized_content": [2, 4833, 8754, 3, 3570, 1973, 1977, 2084, 27585, 14104, 1930, 1988, 16, 4281, 7171, 4833, 8754, 16, 5241, 1927, 4604, 2347, 2112, 1998, 2926, 18, 2955, 16, 1922, 4173, 3]}, "items": [{"id": "p_1857", "content": "Oliguria [SEP] Decreased URINE output that is below the normal range. Oliguria can be defined as urine output of less than or equal to 0.5 or 1", "score": 1, "type": null, "tokenized_content": [2, 4833, 8754, 3, 3261, 6960, 6647, 1988, 1977, 4535, 1920, 2791, 3109, 18, 4833, 8754, 2112, 1998, 3608, 1966, 6960, 6647, 1927, 2941, 2254, 2014, 5557, 1942, 20, 18, 25, 2014, 21, 3]}]}
{"query": {"id": "q_1858", "content": "hypertension [SEP] urely; moreover, bilateral nephrectomy, for treatment of severe hypertension and microangiopathic hemolytic anemia, should be performed with", "tokenized_content": [2, 5579, 3, 6794, 1954, 31, 3950, 16, 7787, 22232, 16, 1958, 2311, 1927, 4010, 5579, 1930, 2703, 9506, 10982, 21515, 10679, 16, 3066, 1998, 2593, 1956, 3]}, "items": [{"id": "p_1858", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_1859", "content": "microangiopathic hemolytic anemia [SEP] bilateral nephrectomy, for treatment of severe hypertension and microangiopathic hemolytic anemia, should be performed with caution.", "tokenized_content": [2, 2703, 9506, 10982, 21515, 10679, 3, 7787, 22232, 16, 1958, 2311, 1927, 4010, 5579, 1930, 2703, 9506, 10982, 21515, 10679, 16, 3066, 1998, 2593, 1956, 12838, 18, 3]}, "items": [{"id": "p_1859", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_1860", "content": "acetylsalicylic acid [SEP] Effects of acetylsalicylic acid, dipyridamole, and hydrocortisone on epinephrine-induced myocar", "tokenized_content": [2, 6894, 23880, 1935, 14523, 2687, 3, 2564, 1927, 6894, 23880, 1935, 14523, 2687, 16, 9137, 3553, 9532, 12492, 1952, 16, 1930, 28184, 1990, 19280, 17, 2719, 15924, 15339, 3]}, "items": [{"id": "p_1860", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_1861", "content": "dipyridamole [SEP] Effects of acetylsalicylic acid, dipyridamole, and hydrocortisone on epinephrine-induced myocardial injury in", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 2564, 1927, 6894, 23880, 1935, 14523, 2687, 16, 9137, 3553, 9532, 12492, 1952, 16, 1930, 28184, 1990, 19280, 17, 2719, 6497, 4047, 1922, 3]}, "items": [{"id": "p_1861", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_1862", "content": "hydrocortisone [SEP] Effects of acetylsalicylic acid, dipyridamole, and hydrocortisone on epinephrine-induced myocardial injury in dogs.", "tokenized_content": [2, 28184, 3, 2564, 1927, 6894, 23880, 1935, 14523, 2687, 16, 9137, 3553, 9532, 12492, 1952, 16, 1930, 28184, 1990, 19280, 17, 2719, 6497, 4047, 1922, 7894, 18, 3]}, "items": [{"id": "p_1862", "content": "Hydrocortisone [SEP] The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, ", "score": 1, "type": null, "tokenized_content": [2, 28184, 3, 1920, 2730, 14469, 8366, 2007, 1920, 10651, 4997, 18, 2496, 6830, 18471, 1977, 2251, 16, 3108, 1966, 1925, 4107, 2014, 12259, 1954, 16, 3]}]}
{"query": {"id": "q_1863", "content": "epinephrine [SEP] ts of acetylsalicylic acid, dipyridamole, and hydrocortisone on epinephrine-induced myocardial injury in dogs.", "tokenized_content": [2, 19280, 3, 4894, 1927, 6894, 23880, 1935, 14523, 2687, 16, 9137, 3553, 9532, 12492, 1952, 16, 1930, 28184, 1990, 19280, 17, 2719, 6497, 4047, 1922, 7894, 18, 3]}, "items": [{"id": "p_1863", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_1864", "content": "myocardial injury [SEP] c acid, dipyridamole, and hydrocortisone on epinephrine-induced myocardial injury in dogs.", "tokenized_content": [2, 6497, 4047, 3, 45, 2687, 16, 9137, 3553, 9532, 12492, 1952, 16, 1930, 28184, 1990, 19280, 17, 2719, 6497, 4047, 1922, 7894, 18, 3]}, "items": [{"id": "p_1864", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1865", "content": "myocardial injury [SEP] A reproducible model for producing diffuse myocardial injury (epinephrine infusion) has been developed to study the cardiopr", "tokenized_content": [2, 6497, 4047, 3, 43, 13257, 2322, 1958, 7144, 9435, 6497, 4047, 12, 19280, 7386, 13, 2258, 2252, 3530, 1942, 2161, 1920, 21129, 2047, 3]}, "items": [{"id": "p_1865", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_1866", "content": "epinephrine [SEP] A reproducible model for producing diffuse myocardial injury (epinephrine infusion) has been developed to study the cardioprotective effe", "tokenized_content": [2, 19280, 3, 43, 13257, 2322, 1958, 7144, 9435, 6497, 4047, 12, 19280, 7386, 13, 2258, 2252, 3530, 1942, 2161, 1920, 28063, 2121, 1021, 3]}, "items": [{"id": "p_1866", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_1867", "content": "myocardial infarction [SEP] of agents or maneuvers which might alter the evolution of acute myocardial infarction. Infusions of epinephrine (4 mug per kilogram per minute for 6 ", "tokenized_content": [2, 6497, 8358, 3, 1927, 4820, 2014, 27576, 1036, 2154, 3284, 4238, 1920, 4854, 1927, 3939, 6497, 8358, 18, 17656, 1927, 19280, 12, 24, 28991, 2079, 13829, 7539, 2079, 8623, 1958, 3]}, "items": [{"id": "p_1867", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_1868", "content": "radiocalcium [SEP] inephrine (4 mug per kilogram per minute for 6 hours) increased radiocalcium uptakes into intact myocardium and each of its subcellular comp", "tokenized_content": [2, 8466, 23327, 2457, 3, 11116, 11419, 12, 24, 28991, 2079, 13829, 7539, 2079, 8623, 1958, 26, 3967, 13, 2502, 8466, 23327, 2457, 5047, 1036, 2460, 6718, 13295, 1930, 2362, 1927, 3]}, "items": [{"id": "p_1868", "content": "Calcium Radioisotopes [SEP] Unstable isotopes of calcium that decay or disintegrate emitting radiation. Ca atoms with atomic weights 39, 41, 45, 47, 49, and", "score": 1, "type": null, "tokenized_content": [2, 5016, 8466, 23854, 27747, 1918, 3, 11976, 29816, 1927, 5016, 1988, 9310, 2014, 22398, 2010, 23341, 5442, 18, 2332, 9030, 1956, 11241, 8845, 3886, 16, 4353, 16, 3607, 16, 4261, 16, 4343, 16, 1930, 3]}]}
{"query": {"id": "q_1869", "content": "calcium [SEP] rine (4 mug per kilogram per minute for 6 hours) increased radiocalcium uptakes into intact myocardium and each of its subcellular comp", "tokenized_content": [2, 5016, 3, 25699, 1021, 12, 24, 28991, 2079, 13829, 7539, 2079, 8623, 1958, 26, 3967, 13, 2502, 8466, 23327, 2457, 5047, 1036, 2460, 6718, 13295, 1930, 2362, 1927, 2496, 11309, 3]}, "items": [{"id": "p_1869", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_1870", "content": "calcium chloride [SEP] .0 vs. 5.0 mg.per 100 Gm. of fat-free dry weight). Infusions of calcium chloride sufficient to raise serum calcium concentrations 2 mEq. per lit", "tokenized_content": [2, 5016, 9140, 3, 18, 20, 3201, 18, 25, 18, 20, 2786, 18, 2079, 2813, 5711, 18, 1927, 3777, 17, 3294, 7143, 3388, 13, 18, 17656, 1927, 5016, 9140, 5409, 1942, 3]}, "items": [{"id": "p_1870", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_1871", "content": "acetylsalicylic acid [SEP] uptakes were significantly decreased in animals pretreated with acetylsalicylic acid or dipyridamole or when hydrocortisone was added to the epineph", "tokenized_content": [2, 6894, 23880, 1935, 14523, 2687, 3, 5047, 1036, 1985, 2567, 3261, 1922, 3555, 12152, 1956, 6894, 23880, 1935, 14523, 2687, 2014, 9137, 3553, 9532, 12492, 1952, 2014, 2469, 28184, 1982, 3]}, "items": [{"id": "p_1871", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_1872", "content": "dipyridamole [SEP] ly decreased in animals pretreated with acetylsalicylic acid or dipyridamole or when hydrocortisone was added to the epinephrine infusion (2", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 7518, 3261, 1922, 3555, 12152, 1956, 6894, 23880, 1935, 14523, 2687, 2014, 9137, 3553, 9532, 12492, 1952, 2014, 2469, 28184, 1982, 4057, 1942, 1920, 3]}, "items": [{"id": "p_1872", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_1873", "content": "hydrocortisone [SEP] ls pretreated with acetylsalicylic acid or dipyridamole or when hydrocortisone was added to the epinephrine infusion (2,682,2,803, and 3,424 c", "tokenized_content": [2, 28184, 3, 6639, 12152, 1956, 6894, 23880, 1935, 14523, 2687, 2014, 9137, 3553, 9532, 12492, 1952, 2014, 2469, 28184, 1982, 4057, 1942, 1920, 19280, 7386, 12, 22, 16, 5117, 1028, 3]}, "items": [{"id": "p_1873", "content": "Hydrocortisone [SEP] The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, ", "score": 1, "type": null, "tokenized_content": [2, 28184, 3, 1920, 2730, 14469, 8366, 2007, 1920, 10651, 4997, 18, 2496, 6830, 18471, 1977, 2251, 16, 3108, 1966, 1925, 4107, 2014, 12259, 1954, 16, 3]}]}
{"query": {"id": "q_1874", "content": "Acetylsalicylic acid [SEP] damage was graded as less severe in the three treatment groups. Acetylsalicylic acid, dipyridamole, and hydrocortisone all appear to have cardioprot", "tokenized_content": [2, 6894, 23880, 1935, 14523, 2687, 3, 4293, 1982, 13175, 1966, 2941, 4010, 1922, 1920, 2559, 2311, 2671, 18, 6894, 23880, 1935, 14523, 2687, 16, 9137, 3553, 9532, 12492, 1952, 16, 3]}, "items": [{"id": "p_1874", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_1875", "content": "depressive [SEP] Changes in depressive status associated with topical beta-blockers.", "tokenized_content": [2, 7745, 3, 2840, 1922, 7745, 3642, 2458, 1956, 12259, 4666, 17, 13628, 18, 3]}, "items": [{"id": "p_1875", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_1876", "content": "Depression [SEP] Depression and sexual dysfunction have been related to side effects of top", "tokenized_content": [2, 4621, 3, 4621, 1930, 5702, 5273, 2162, 2252, 2712, 1942, 4159, 2564, 1927, 3700, 3]}, "items": [{"id": "p_1876", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_1877", "content": "sexual dysfunction [SEP] Depression and sexual dysfunction have been related to side effects of topical beta-blockers. We ", "tokenized_content": [2, 5702, 5273, 3, 4621, 1930, 5702, 5273, 2162, 2252, 2712, 1942, 4159, 2564, 1927, 12259, 4666, 17, 13628, 18, 2038, 3]}, "items": [{"id": "p_1877", "content": "Sexual Dysfunction, Physiological [SEP] Physiological disturbances in normal sexual performance in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5702, 5273, 16, 5005, 3, 5005, 12654, 1922, 2791, 5702, 3604, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_1878", "content": "timolol [SEP]  determine any difference between a non selective beta-blocker (timolol) and a selective beta-blocker (betaxolol) regarding CNS side ef", "tokenized_content": [2, 2267, 23646, 3, 3415, 2967, 3175, 2192, 43, 2447, 5328, 4666, 17, 14580, 12, 2267, 23646, 13, 1930, 43, 5328, 4666, 17, 14580, 12, 4666, 1039, 23646, 13, 4667, 7520, 3]}, "items": [{"id": "p_1878", "content": "Timolol [SEP] A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as ", "score": 1, "type": null, "tokenized_content": [2, 2267, 23646, 3, 43, 4666, 17, 13672, 8151, 2551, 1922, 4615, 1942, 21395, 18, 1920, 30129, 17, 15348, 1977, 1920, 2253, 3500, 18, 2267, 23646, 2258, 2252, 4211, 1966, 3]}]}
{"query": {"id": "q_1879", "content": "betaxolol [SEP]  selective beta-blocker (timolol) and a selective beta-blocker (betaxolol) regarding CNS side effects. Eight glaucomatous patients chroni", "tokenized_content": [2, 4666, 1039, 23646, 3, 5328, 4666, 17, 14580, 12, 2267, 23646, 13, 1930, 43, 5328, 4666, 17, 14580, 12, 4666, 1039, 23646, 13, 4667, 7520, 4159, 2564, 18, 5066, 12106, 3]}, "items": [{"id": "p_1879", "content": "Betaxolol [SEP] A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4666, 1039, 23646, 3, 43, 21129, 4127, 25419, 2185, 4666, 17, 21, 17, 13672, 8151, 1956, 2239, 5740, 7829, 2455, 18, 3]}]}
{"query": {"id": "q_1880", "content": "glaucomatous [SEP] tive beta-blocker (betaxolol) regarding CNS side effects. Eight glaucomatous patients chronically treated with timolol 0.5%/12h, suffering f", "tokenized_content": [2, 12106, 4575, 1957, 3, 8685, 1961, 4666, 17, 14580, 12, 4666, 1039, 23646, 13, 4667, 7520, 4159, 2564, 18, 5066, 12106, 4575, 1957, 2132, 16132, 2868, 1956, 2267, 23646, 20, 3]}, "items": [{"id": "p_1880", "content": "Glaucoma [SEP] An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the int", "score": 1, "type": null, "tokenized_content": [2, 12106, 3, 1925, 10046, 2573, 16, 6966, 1922, 3086, 4952, 16, 4537, 1966, 2496, 3065, 3779, 1925, 11976, 2014, 43, 7637, 2760, 1922, 1920, 2218, 3]}]}
{"query": {"id": "q_1881", "content": "depression [SEP] ients chronically treated with timolol 0.5%/12h, suffering from depression diagnosed through DMS-III-R criteria, were included in the stud", "tokenized_content": [2, 4621, 3, 10116, 4905, 1036, 16132, 2868, 1956, 2267, 23646, 20, 18, 25, 9, 19, 2369, 1023, 16, 11364, 2037, 4621, 5377, 2596, 20567, 17, 4337, 17, 60, 4164, 16, 3]}, "items": [{"id": "p_1881", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_1882", "content": "ifosfamide [SEP] Long-term follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tu", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 2815, 17, 2576, 2396, 17, 2353, 1927, 2647, 1951, 6016, 16408, 1021, 4604, 5532, 1922, 3069, 2868, 1958, 6558, 9152, 9037, 3]}, "items": [{"id": "p_1882", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_1883", "content": "renal toxicity [SEP] Long-term follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an Intern", "tokenized_content": [2, 4604, 5532, 3, 2815, 17, 2576, 2396, 17, 2353, 1927, 2647, 1951, 6016, 16408, 1021, 4604, 5532, 1922, 3069, 2868, 1958, 6558, 9152, 3861, 30, 1925, 5035, 3]}, "items": [{"id": "p_1883", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1884", "content": "malignant mesenchymal tumors [SEP]  follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an International Society of Pediatric Oncology report.", "tokenized_content": [2, 6558, 9152, 3861, 3, 2396, 17, 2353, 1927, 2647, 1951, 6016, 16408, 1021, 4604, 5532, 1922, 3069, 2868, 1958, 6558, 9152, 3861, 30, 1925, 6019, 7564, 1927, 7460, 11605, 3809, 3]}, "items": [{"id": "p_1884", "content": "Malignant mesenchymal tumor [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6558, 9152, 2798, 3, 3]}]}
{"query": {"id": "q_1885", "content": "malignant mesenchymal tumors [SEP] The renal function of 74 children with malignant mesenchymal tumors in complete remission and who have received the same ifosfamide", "tokenized_content": [2, 6558, 9152, 3861, 3, 1920, 4604, 2347, 1927, 5446, 3069, 1956, 6558, 9152, 3861, 1922, 4080, 10221, 1930, 2746, 2162, 4004, 1920, 2841, 2647, 1951, 6016, 16408, 1021, 3]}, "items": [{"id": "p_1885", "content": "Malignant mesenchymal tumor [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6558, 9152, 2798, 3, 3]}]}
{"query": {"id": "q_1886", "content": "ifosfamide [SEP] mal tumors in complete remission and who have received the same ifosfamide chemotherapy protocol (International Society of Pediatric Oncol", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 3054, 3861, 1922, 4080, 10221, 1930, 2746, 2162, 4004, 1920, 2841, 2647, 1951, 6016, 16408, 1021, 5318, 4478, 12, 6019, 7564, 1927, 7460, 5595, 3]}, "items": [{"id": "p_1886", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_1887", "content": "Malignant Mesenchymal Tumor [SEP] motherapy protocol (International Society of Pediatric Oncology Malignant Mesenchymal Tumor Study 84 [SIOP MMT 84]) were studied 1 year after the completio", "tokenized_content": [2, 6558, 9152, 2798, 3, 7999, 18644, 4478, 12, 6019, 7564, 1927, 7460, 11605, 6558, 9152, 2798, 2161, 5686, 37, 5998, 2011, 18866, 5686, 39, 13, 1985, 3942, 21, 2476, 2256, 3]}, "items": [{"id": "p_1887", "content": "Malignant mesenchymal tumor [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6558, 9152, 2798, 3, 3]}]}
{"query": {"id": "q_1888", "content": "ifosfamide, vincristine, and dactinomycin [SEP] ive doses were 36 or 60 g/m2 of ifosfamide (six or 10 cycles of ifosfamide, vincristine, and dactinomycin [IVA]). None of them had received cisplatin chemotherapy. Ages ", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 16, 25446, 16, 1930, 22322, 2268, 7928, 3, 4370, 1021, 5312, 1985, 3480, 2014, 3276, 49, 19, 6056, 1927, 2647, 1951, 6016, 16408, 1021, 12, 3]}, "items": [{"id": "p_1888", "content": "IVA protocol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4370, 1019, 4478, 3, 3]}]}
{"query": {"id": "q_1889", "content": "IVA [SEP] (six or 10 cycles of ifosfamide, vincristine, and dactinomycin [IVA]). None of them had received cisplatin chemotherapy. Ages range", "tokenized_content": [2, 4370, 1019, 3, 12, 3798, 2014, 2119, 6355, 1927, 2647, 1951, 6016, 16408, 1021, 16, 25446, 16, 1930, 22322, 2268, 7928, 37, 4370, 1019, 39, 13, 18, 6046, 1927, 3581, 3]}, "items": [{"id": "p_1889", "content": "IVA protocol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4370, 1019, 4478, 3, 3]}]}
{"query": {"id": "q_1890", "content": "cisplatin [SEP] vincristine, and dactinomycin [IVA]). None of them had received cisplatin chemotherapy. Ages ranged from 4 months to 17 years; 58 patient", "tokenized_content": [2, 9284, 3, 25446, 16, 1930, 22322, 2268, 7928, 37, 4370, 1019, 39, 13, 18, 6046, 1927, 3581, 2430, 4004, 9284, 5318, 18, 7684, 7065, 2037, 24, 3221, 1942, 2752, 2739, 3]}, "items": [{"id": "p_1890", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_1891", "content": "tumor [SEP] The renal function of 74 children with malignant mesenchymal tumors in complete remission and who have received the same ifosfamid", "tokenized_content": [2, 2798, 3, 1920, 4604, 2347, 1927, 5446, 3069, 1956, 6558, 9152, 3861, 1922, 4080, 10221, 1930, 2746, 2162, 4004, 1920, 2841, 2647, 1951, 6016, 16408, 3]}, "items": [{"id": "p_1891", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1892", "content": "glucosuria [SEP]  was investigated by measuring plasma and urinary electrolytes, glucosuria, proteinuria, aminoaciduria, urinary pH, osmolarity, creatinine", "tokenized_content": [2, 3351, 1951, 8754, 3, 1982, 3845, 2007, 6711, 3582, 1930, 7075, 25308, 16, 3351, 1951, 8754, 16, 15831, 16, 3835, 29272, 8754, 16, 7075, 2087, 16, 30296, 16, 9374, 3]}, "items": [{"id": "p_1892", "content": "Glycosuria, Renal [SEP] An autosomal inherited disorder due to defective reabsorption of GLUCOSE by the PROXIMAL RENAL TUBULES. The urinary loss of gluc", "score": 1, "type": null, "tokenized_content": [2, 7533, 8754, 16, 4604, 3, 1925, 13027, 12911, 4770, 2810, 1942, 9785, 26287, 1927, 3817, 2007, 1920, 6863, 4604, 14876, 18, 1920, 7075, 3257, 1927, 3351, 3]}]}
{"query": {"id": "q_1893", "content": "proteinuria [SEP] gated by measuring plasma and urinary electrolytes, glucosuria, proteinuria, aminoaciduria, urinary pH, osmolarity, creatinine clearance, p", "tokenized_content": [2, 15831, 3, 12336, 2007, 6711, 3582, 1930, 7075, 25308, 16, 3351, 1951, 8754, 16, 15831, 16, 3835, 29272, 8754, 16, 7075, 2087, 16, 30296, 16, 9374, 7802, 16, 58, 3]}, "items": [{"id": "p_1893", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_1894", "content": "aminoaciduria [SEP] uring plasma and urinary electrolytes, glucosuria, proteinuria, aminoaciduria, urinary pH, osmolarity, creatinine clearance, phosphate tubula", "tokenized_content": [2, 3835, 29272, 8754, 3, 3674, 1941, 3582, 1930, 7075, 25308, 16, 3351, 1951, 8754, 16, 15831, 16, 3835, 29272, 8754, 16, 7075, 2087, 16, 30296, 16, 9374, 7802, 16, 5413, 3]}, "items": [{"id": "p_1894", "content": "Renal Aminoacidurias [SEP] A group of inherited kidney disorders characterized by the abnormally elevated levels of AMINO ACIDS in URINE. Genetic mutations", "score": 1, "type": null, "tokenized_content": [2, 4604, 3835, 29272, 8754, 1036, 3, 43, 2210, 1927, 12911, 5245, 4414, 4378, 2007, 1920, 20756, 4664, 2428, 1927, 3835, 4576, 1922, 6960, 18, 3299, 3527, 3]}]}
{"query": {"id": "q_1895", "content": "creatinine [SEP] glucosuria, proteinuria, aminoaciduria, urinary pH, osmolarity, creatinine clearance, phosphate tubular reabsorption, beta 2 microglobulin", "tokenized_content": [2, 9374, 3, 3351, 1951, 8754, 16, 15831, 16, 3835, 29272, 8754, 16, 7075, 2087, 16, 30296, 16, 9374, 7802, 16, 5413, 11755, 26287, 16, 4666, 22, 7586, 18733, 3]}, "items": [{"id": "p_1895", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_1896", "content": "phosphate [SEP] a, aminoaciduria, urinary pH, osmolarity, creatinine clearance, phosphate tubular reabsorption, beta 2 microglobulinuria, and lysozymuria", "tokenized_content": [2, 5413, 3, 43, 16, 3835, 29272, 8754, 16, 7075, 2087, 16, 30296, 16, 9374, 7802, 16, 5413, 11755, 26287, 16, 4666, 22, 7586, 18733, 8754, 16, 1930, 3629, 4490, 2229, 3]}, "items": [{"id": "p_1896", "content": "Phosphates [SEP] Inorganic salts of phosphoric acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26473, 3, 13849, 16028, 1927, 3421, 1935, 2687, 18, 3]}]}
{"query": {"id": "q_1897", "content": "renal abnormalities [SEP] nts (78%) had normal renal tests, whereas 16 patients (22%) had renal abnormalities. Two subsets of patients were identified from this latter group", "tokenized_content": [2, 4604, 6754, 3, 17969, 12, 5440, 9, 13, 2430, 2791, 4604, 4026, 16, 3417, 2641, 2132, 12, 2950, 9, 13, 2430, 4604, 6754, 18, 2288, 9524, 1927, 2132, 1985, 2899, 3]}, "items": [{"id": "p_1897", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_1898", "content": "toxicity [SEP]  four patients (5% of the total population) who developed major toxicity resulting in Fanconi's syndrome (TDFS); and the second group in", "tokenized_content": [2, 5532, 3, 3006, 2132, 12, 25, 9, 1927, 1920, 2698, 2973, 13, 2746, 3530, 3044, 5532, 3864, 1922, 17431, 13339, 11, 61, 4741, 12, 25062, 1036, 13, 31, 1930, 1920, 3]}, "items": [{"id": "p_1898", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_1899", "content": "Fanconi's syndrome [SEP] the total population) who developed major toxicity resulting in Fanconi's syndrome (TDFS); and the second group included five patients with elevat", "tokenized_content": [2, 17431, 13339, 11, 61, 4741, 3, 1920, 2698, 2973, 13, 2746, 3530, 3044, 5532, 3864, 1922, 17431, 13339, 11, 61, 4741, 12, 25062, 1036, 13, 31, 1930, 1920, 2812, 2210, 3]}, "items": [{"id": "p_1899", "content": "Fanconi Syndrome [SEP] A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY", "score": 1, "type": null, "tokenized_content": [2, 17431, 13339, 4741, 3, 43, 16321, 2014, 5815, 2386, 1927, 9612, 5273, 1927, 1920, 6863, 5245, 17946, 2979, 3065, 5668, 1927, 1920, 5245, 3]}]}
{"query": {"id": "q_1900", "content": "TDFS [SEP] ) who developed major toxicity resulting in Fanconi's syndrome (TDFS); and the second group included five patients with elevated bet", "tokenized_content": [2, 25062, 1036, 3, 13, 2746, 3530, 3044, 5532, 3864, 1922, 17431, 13339, 11, 61, 4741, 12, 25062, 1036, 13, 31, 1930, 1920, 2812, 2210, 3063, 3628, 2132, 1956, 4664, 2143, 3]}, "items": [{"id": "p_1900", "content": "Fanconi Syndrome [SEP] A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY", "score": 1, "type": null, "tokenized_content": [2, 17431, 13339, 4741, 3, 43, 16321, 2014, 5815, 2386, 1927, 9612, 5273, 1927, 1920, 6863, 5245, 17946, 2979, 3065, 5668, 1927, 1920, 5245, 3]}]}
{"query": {"id": "q_1901", "content": "mesenchymal tumors [SEP] The renal function of 74 children with malignant mesenchymal tumors in complete remission and who have received the same ifosfamide", "tokenized_content": [2, 9152, 3861, 3, 1920, 4604, 2347, 1927, 5446, 3069, 1956, 6558, 9152, 3861, 1922, 4080, 10221, 1930, 2746, 2162, 4004, 1920, 2841, 2647, 1951, 6016, 16408, 1021, 3]}, "items": [{"id": "p_1901", "content": "Malignant mesenchymal tumor [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6558, 9152, 2798, 3, 3]}]}
{"query": {"id": "q_1902", "content": "dopamine [SEP] Evidence for an involvement of D1 and D2 dopamine receptors in mediating nicotine-induced hyperactivity in rats.", "tokenized_content": [2, 7964, 3, 3095, 1958, 1925, 5668, 1927, 8524, 1930, 8631, 7964, 4086, 1922, 10239, 9303, 17, 2719, 15534, 1922, 3615, 18, 3]}, "items": [{"id": "p_1902", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1903", "content": "nicotine [SEP] for an involvement of D1 and D2 dopamine receptors in mediating nicotine-induced hyperactivity in rats.", "tokenized_content": [2, 9303, 3, 1958, 1925, 5668, 1927, 8524, 1930, 8631, 7964, 4086, 1922, 10239, 9303, 17, 2719, 15534, 1922, 3615, 18, 3]}, "items": [{"id": "p_1903", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_1904", "content": "hyperactivity [SEP] t of D1 and D2 dopamine receptors in mediating nicotine-induced hyperactivity in rats.", "tokenized_content": [2, 15534, 3, 62, 1927, 8524, 1930, 8631, 7964, 4086, 1922, 10239, 9303, 17, 2719, 15534, 1922, 3615, 18, 3]}, "items": [{"id": "p_1904", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1905", "content": "nicotine [SEP] drug or to the experimental environment is necessary to observe nicotine-induced locomotor stimulation. In the present study the role of", "tokenized_content": [2, 9303, 3, 2838, 2014, 1942, 1920, 3599, 3515, 1977, 4680, 1942, 7974, 9303, 17, 2719, 13594, 4177, 18, 1922, 1920, 2481, 2161, 1920, 2770, 1927, 3]}, "items": [{"id": "p_1905", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_1906", "content": "dopamine [SEP] fect of nicotine in rats was examined. In addition, the role of dopamine receptors in mediating nicotine-induced locomotor stimulation w", "tokenized_content": [2, 7964, 3, 16688, 1031, 1927, 9303, 1922, 3615, 1982, 3572, 18, 1922, 2459, 16, 1920, 2770, 1927, 7964, 4086, 1922, 10239, 9303, 17, 2719, 13594, 4177, 65, 3]}, "items": [{"id": "p_1906", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_1907", "content": "Nicotine [SEP] assessed in male Sprague-Dawley rats tested in photocell cages. Nicotine (1.0 mg/kg) caused a significant increase in locomotor activity", "tokenized_content": [2, 9303, 3, 3683, 1922, 4005, 15684, 17, 15798, 3615, 3620, 1922, 14111, 1992, 16136, 18, 9303, 12, 21, 18, 20, 2786, 19, 3621, 13, 4189, 43, 2228, 2760, 1922, 13594, 3]}, "items": [{"id": "p_1907", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_1908", "content": "increase in locomotor activity [SEP] d in photocell cages. Nicotine (1.0 mg/kg) caused a significant increase in locomotor activity in rats that were habituated to the test environment, but had o", "tokenized_content": [2, 2760, 1922, 13594, 2455, 3, 46, 1922, 14111, 1992, 16136, 18, 9303, 12, 21, 18, 20, 2786, 19, 3621, 13, 4189, 43, 2228, 2760, 1922, 13594, 2455, 1922, 3615, 1988, 3]}, "items": [{"id": "p_1908", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1909", "content": "mecamylamine [SEP] ion of nicotine was blocked by the central nicotinic antagonist mecamylamine but not by the peripheral nicotinic blocker hexamethonium, indi", "tokenized_content": [2, 10685, 27302, 3812, 3, 4755, 1927, 9303, 1982, 6923, 2007, 1920, 4101, 20239, 8151, 10685, 27302, 3812, 2308, 2084, 2007, 1920, 5009, 20239, 14580, 7142, 10758, 15414, 16, 2063, 1033, 3]}, "items": [{"id": "p_1909", "content": "Mecamylamine [SEP] A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine h", "score": 1, "type": null, "tokenized_content": [2, 10685, 27302, 3812, 3, 43, 20239, 8151, 1988, 1977, 2486, 14504, 2037, 1920, 8375, 6482, 1930, 17553, 1920, 2877, 17, 3068, 7104, 18, 10685, 27302, 3812, 50, 3]}]}
{"query": {"id": "q_1910", "content": "hexamethonium [SEP] gonist mecamylamine but not by the peripheral nicotinic blocker hexamethonium, indicating that the response is probably mediated by central n", "tokenized_content": [2, 7142, 10758, 15414, 3, 8239, 2184, 10685, 27302, 3812, 2308, 2084, 2007, 1920, 5009, 20239, 14580, 7142, 10758, 15414, 16, 4168, 1988, 1920, 2644, 1977, 6226, 3434, 2007, 4101, 56, 3]}, "items": [{"id": "p_1910", "content": "Hexamethonium [SEP] A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gast", "score": 1, "type": null, "tokenized_content": [2, 7142, 10758, 15414, 3, 43, 20239, 13908, 8151, 3868, 6656, 1942, 1966, 1920, 29183, 12516, 1935, 14580, 18, 2176, 1977, 7865, 14504, 2037, 1920, 6215, 3]}]}
{"query": {"id": "q_1911", "content": "hyperactivity [SEP] bably mediated by central nicotinic receptors. Nicotine-induced hyperactivity was blocked by the selective D1 antagonist SCH 23390, the selec", "tokenized_content": [2, 15534, 3, 9560, 1954, 3434, 2007, 4101, 20239, 4086, 18, 9303, 17, 2719, 15534, 1982, 6923, 2007, 1920, 5328, 8524, 8151, 2966, 19598, 5124, 16, 1920, 2484, 1940, 3]}, "items": [{"id": "p_1911", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_1912", "content": "SCH 23390 [SEP] nduced hyperactivity was blocked by the selective D1 antagonist SCH 23390, the selective D2 antagonist raclopride and the D1/D2 antagonis", "tokenized_content": [2, 2966, 19598, 5124, 3, 8026, 2418, 15534, 1982, 6923, 2007, 1920, 5328, 8524, 8151, 2966, 19598, 5124, 16, 1920, 5328, 8631, 8151, 7195, 6012, 2047, 2261, 1930, 1920, 8524, 19, 3]}, "items": [{"id": "p_1912", "content": "SCH 23390 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2966, 19598, 5124, 3, 3]}]}
{"query": {"id": "q_1913", "content": "raclopride [SEP]  selective D1 antagonist SCH 23390, the selective D2 antagonist raclopride and the D1/D2 antagonist fluphenazine. Pretreatment with the D2", "tokenized_content": [2, 7195, 6012, 2047, 2261, 3, 5328, 8524, 8151, 2966, 19598, 5124, 16, 1920, 5328, 8631, 8151, 7195, 6012, 2047, 2261, 1930, 1920, 8524, 19, 8631, 8151, 2848, 17616, 10119, 18, 3]}, "items": [{"id": "p_1913", "content": "Raclopride [SEP] A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.", "score": 1, "type": null, "tokenized_content": [2, 7195, 6012, 2047, 2261, 3, 43, 11798, 7334, 5482, 1988, 2258, 17581, 3879, 18, 2176, 1977, 43, 7964, 8631, 3148, 12, 3365, 4086, 16, 7964, 8631, 13, 8151, 18, 3]}]}
{"query": {"id": "q_1914", "content": "fluphenazine [SEP] the selective D2 antagonist raclopride and the D1/D2 antagonist fluphenazine. Pretreatment with the D2 agonist PHNO enhanced nicotine-induce", "tokenized_content": [2, 2848, 17616, 10119, 3, 1920, 5328, 8631, 8151, 7195, 6012, 2047, 2261, 1930, 1920, 8524, 19, 8631, 8151, 2848, 17616, 10119, 18, 9111, 1956, 1920, 8631, 7829, 2087, 11873, 4256, 3]}, "items": [{"id": "p_1914", "content": "Fluphenazine [SEP] A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.\n  ", "score": 1, "type": null, "tokenized_content": [2, 2848, 17616, 10119, 3, 43, 3037, 30354, 2053, 2251, 1922, 1920, 2311, 1927, 9855, 1918, 18, 2496, 3879, 1930, 7947, 2032, 4933, 2551, 1942, 2690, 1927, 4891, 2216, 3368, 22030, 2912, 18, 3]}]}
{"query": {"id": "q_1915", "content": "SKF 38393 [SEP] enhanced nicotine-induced hyperactivity, whereas the D1 agonist SKF 38393 had no effect. The results indicate that acute nicotine injecti", "tokenized_content": [2, 3097, 1038, 27787, 11436, 3, 4256, 9303, 17, 2719, 15534, 16, 3417, 1920, 8524, 7829, 3097, 1038, 27787, 11436, 2430, 2239, 2495, 18, 1920, 2274, 3579, 1988, 3939, 9303, 27270, 3]}, "items": [{"id": "p_1915", "content": "2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine [SEP] A selective D1 dopamine receptor agonist used primarily as a research tool.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22, 16, 23, 16, 24, 16, 25, 17, 21196, 17, 27, 16, 28, 17, 20684, 17, 21, 17, 7971, 17, 5189, 17, 23, 17, 7334, 25360, 3, 43, 5328, 8524, 7964, 3148, 7829, 2251, 5985, 1966, 43, 2659, 5229, 18, 3]}]}
{"query": {"id": "q_1916", "content": "mefloquine [SEP] Neuropsychiatric side effects after the use of mefloquine.", "tokenized_content": [2, 17925, 6012, 15520, 3, 19305, 4159, 2564, 2256, 1920, 2485, 1927, 17925, 6012, 15520, 18, 3]}, "items": [{"id": "p_1916", "content": "Mefloquine [SEP] A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few s", "score": 1, "type": null, "tokenized_content": [2, 17925, 6012, 15520, 3, 43, 14608, 17, 8615, 27290, 2838, 12, 27290, 1036, 13, 18, 2176, 1977, 3345, 3655, 3316, 15663, 13098, 1956, 3345, 3855, 61, 3]}]}
{"query": {"id": "q_1917", "content": "mefloquine [SEP]  neuropsychiatric side effects in patients after treatment with mefloquine. Reactions consisted mainly of seizures, acute psychoses, anxie", "tokenized_content": [2, 17925, 6012, 15520, 3, 19305, 4159, 2564, 1922, 2132, 2256, 2311, 1956, 17925, 6012, 15520, 18, 5298, 6994, 4994, 1927, 10060, 16, 3939, 9855, 1918, 16, 24400, 1021, 3]}, "items": [{"id": "p_1917", "content": "Mefloquine [SEP] A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few s", "score": 1, "type": null, "tokenized_content": [2, 17925, 6012, 15520, 3, 43, 14608, 17, 8615, 27290, 2838, 12, 27290, 1036, 13, 18, 2176, 1977, 3345, 3655, 3316, 15663, 13098, 1956, 3345, 3855, 61, 3]}]}
{"query": {"id": "q_1918", "content": "seizures [SEP]  after treatment with mefloquine. Reactions consisted mainly of seizures, acute psychoses, anxiety neurosis, and major disturbances of s", "tokenized_content": [2, 10060, 3, 2256, 2311, 1956, 17925, 6012, 15520, 18, 5298, 6994, 4994, 1927, 10060, 16, 3939, 9855, 1918, 16, 5592, 7318, 1937, 16, 1930, 3044, 12654, 1927, 61, 3]}, "items": [{"id": "p_1918", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_1919", "content": "psychoses [SEP]  with mefloquine. Reactions consisted mainly of seizures, acute psychoses, anxiety neurosis, and major disturbances of sleep-wake rhythm.", "tokenized_content": [2, 9855, 1918, 3, 1956, 17925, 6012, 15520, 18, 5298, 6994, 4994, 1927, 10060, 16, 3939, 9855, 1918, 16, 5592, 7318, 1937, 16, 1930, 3044, 12654, 1927, 5006, 17, 14763, 11529, 3]}, "items": [{"id": "p_1919", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_1920", "content": "anxiety neurosis [SEP] quine. Reactions consisted mainly of seizures, acute psychoses, anxiety neurosis, and major disturbances of sleep-wake rhythm. Side effects occu", "tokenized_content": [2, 5592, 7318, 1937, 3, 9012, 1021, 18, 5298, 6994, 4994, 1927, 10060, 16, 3939, 9855, 1918, 16, 5592, 7318, 1937, 16, 1930, 3044, 12654, 1927, 5006, 17, 14763, 11529, 18, 3]}, "items": [{"id": "p_1920", "content": "Anxiety Disorders [SEP] Persistent and disabling ANXIETY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5592, 4414, 3, 7733, 1930, 27606, 5592, 18, 3]}]}
{"query": {"id": "q_1921", "content": "disturbances of sleep-wake rhythm [SEP] ainly of seizures, acute psychoses, anxiety neurosis, and major disturbances of sleep-wake rhythm. Side effects occurred after both therapeutic and prophylactic ", "tokenized_content": [2, 12654, 1927, 5006, 17, 14763, 11529, 3, 9798, 20523, 1012, 1927, 10060, 16, 3939, 9855, 1918, 16, 5592, 7318, 1937, 16, 1930, 3044, 12654, 1927, 5006, 17, 14763, 11529, 18, 3]}, "items": [{"id": "p_1921", "content": "Sleep Disorders [SEP] Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major c", "score": 1, "type": null, "tokenized_content": [2, 5006, 4414, 3, 2961, 4378, 2007, 12654, 1927, 10616, 5006, 4147, 2014, 5888, 18, 5006, 4414, 2278, 1998, 5831, 2460, 2559, 3044, 45, 3]}]}
{"query": {"id": "q_1922", "content": "malaria [SEP] gher than after prophylaxis. Therefore, certain limitations for malaria prophylaxis and treatment with mefloquine are recommended.", "tokenized_content": [2, 7505, 3, 6101, 1915, 2254, 2256, 12725, 18, 2955, 16, 4908, 5780, 1958, 7505, 12725, 1930, 2311, 1956, 17925, 6012, 15520, 2032, 6198, 18, 3]}, "items": [{"id": "p_1922", "content": "Malaria [SEP] A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIU", "score": 1, "type": null, "tokenized_content": [2, 7505, 3, 43, 23583, 13642, 1928, 2573, 4189, 1922, 5209, 2007, 3006, 3038, 1927, 1920, 15663, 9487, 30, 15663, 13098, 31, 15663, 20236, 31, 3018, 15799, 1032, 3]}]}
{"query": {"id": "q_1923", "content": "pain [SEP] Reduction in injection pain using buffered lidocaine as a local anesthetic before cardiac c", "tokenized_content": [2, 3594, 3, 3378, 1922, 4107, 3594, 2193, 9480, 19567, 1966, 43, 3076, 16111, 3119, 4435, 45, 3]}, "items": [{"id": "p_1923", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_1924", "content": "lidocaine [SEP] Reduction in injection pain using buffered lidocaine as a local anesthetic before cardiac catheterization.", "tokenized_content": [2, 19567, 3, 3378, 1922, 4107, 3594, 2193, 9480, 19567, 1966, 43, 3076, 16111, 3119, 4435, 19779, 18, 3]}, "items": [{"id": "p_1924", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_1925", "content": "pain [SEP] Previous reports have suggested that pain associated with the injection of lidocaine is related to the ac", "tokenized_content": [2, 3594, 3, 2555, 4710, 2162, 3978, 1988, 3594, 2458, 1956, 1920, 4107, 1927, 19567, 1977, 2712, 1942, 1920, 2000, 3]}, "items": [{"id": "p_1925", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_1926", "content": "lidocaine [SEP] ports have suggested that pain associated with the injection of lidocaine is related to the acidic pH of the solution. To determine if th", "tokenized_content": [2, 19567, 3, 9260, 1036, 2162, 3978, 1988, 3594, 2458, 1956, 1920, 4107, 1927, 19567, 1977, 2712, 1942, 1920, 9931, 2087, 1927, 1920, 3331, 18, 1942, 3415, 2647, 1913, 3]}, "items": [{"id": "p_1926", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_1927", "content": "mazindol [SEP] Randomized, double-blind trial of mazindol in Duchenne dystrophy.", "tokenized_content": [2, 26701, 2762, 1945, 3, 5542, 16, 4825, 17, 7109, 3046, 1927, 26701, 2762, 1945, 1922, 10677, 22467, 2912, 19321, 18, 3]}, "items": [{"id": "p_1927", "content": "Mazindol [SEP] Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptak", "score": 1, "type": null, "tokenized_content": [2, 26701, 2762, 1945, 3, 12258, 13153, 19809, 21575, 5899, 10295, 1942, 1930, 2941, 6161, 2254, 19057, 16, 2308, 1956, 2673, 2551, 4159, 2564, 18, 2176, 7042, 2353, 3857, 1040, 3]}]}
{"query": {"id": "q_1928", "content": "Duchenne dystrophy [SEP] Randomized, double-blind trial of mazindol in Duchenne dystrophy.", "tokenized_content": [2, 10677, 22467, 2912, 19321, 3, 5542, 16, 4825, 17, 7109, 3046, 1927, 26701, 2762, 1945, 1922, 10677, 22467, 2912, 19321, 18, 3]}, "items": [{"id": "p_1928", "content": "Muscular Dystrophy, Duchenne [SEP] An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the int", "score": 1, "type": null, "tokenized_content": [2, 12330, 19321, 16, 10677, 22467, 2912, 3, 1925, 66, 17, 4624, 13992, 3760, 2573, 4189, 2007, 1925, 11752, 1942, 15541, 23678, 16, 2154, 1977, 3286, 1956, 8231, 1920, 2218, 3]}]}
{"query": {"id": "q_1929", "content": "weakness [SEP] idence that growth hormone may be related to the progression of weakness in Duchenne dystrophy. We conducted a 12-month controlled trial", "tokenized_content": [2, 12175, 3, 6023, 1972, 1988, 2905, 6365, 2278, 1998, 2712, 1942, 1920, 4380, 1927, 12175, 1922, 10677, 22467, 2912, 19321, 18, 2038, 3609, 43, 2369, 17, 2935, 4642, 3046, 3]}, "items": [{"id": "p_1929", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_1930", "content": "Duchenne dystrophy [SEP] growth hormone may be related to the progression of weakness in Duchenne dystrophy. We conducted a 12-month controlled trial of mazindol, a putati", "tokenized_content": [2, 10677, 22467, 2912, 19321, 3, 2905, 6365, 2278, 1998, 2712, 1942, 1920, 4380, 1927, 12175, 1922, 10677, 22467, 2912, 19321, 18, 2038, 3609, 43, 2369, 17, 2935, 4642, 3046, 1927, 3]}, "items": [{"id": "p_1930", "content": "Muscular Dystrophy, Duchenne [SEP] An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the int", "score": 1, "type": null, "tokenized_content": [2, 12330, 19321, 16, 10677, 22467, 2912, 3, 1925, 66, 17, 4624, 13992, 3760, 2573, 4189, 2007, 1925, 11752, 1942, 15541, 23678, 16, 2154, 1977, 3286, 1956, 8231, 1920, 2218, 3]}]}
{"query": {"id": "q_1931", "content": "mazindol [SEP] Duchenne dystrophy. We conducted a 12-month controlled trial of mazindol, a putative growth hormone secretion inhibitor, in 83 boys with", "tokenized_content": [2, 26701, 2762, 1945, 3, 10677, 22467, 2912, 19321, 18, 2038, 3609, 43, 2369, 17, 2935, 4642, 3046, 1927, 26701, 2762, 1945, 16, 43, 6770, 2905, 6365, 5512, 4106, 16, 1922, 3]}, "items": [{"id": "p_1931", "content": "Mazindol [SEP] Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptak", "score": 1, "type": null, "tokenized_content": [2, 26701, 2762, 1945, 3, 12258, 13153, 19809, 21575, 5899, 10295, 1942, 1930, 2941, 6161, 2254, 19057, 16, 2308, 1956, 2673, 2551, 4159, 2564, 18, 2176, 7042, 2353, 3857, 1040, 3]}]}
{"query": {"id": "q_1932", "content": "Mazindol [SEP] e expected rate of progression of weakness at P less than 0.05. Mazindol did not benefit strength at any point in the study. Side effect", "tokenized_content": [2, 26701, 2762, 1945, 3, 47, 4100, 2769, 1927, 4380, 1927, 12175, 2019, 58, 2941, 2254, 20, 18, 2914, 18, 26701, 2762, 1945, 2811, 2084, 5580, 4568, 2019, 2967, 3575, 1922, 3]}, "items": [{"id": "p_1932", "content": "Mazindol [SEP] Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptak", "score": 1, "type": null, "tokenized_content": [2, 26701, 2762, 1945, 3, 12258, 13153, 19809, 21575, 5899, 10295, 1942, 1930, 2941, 6161, 2254, 19057, 16, 2308, 1956, 2673, 2551, 4159, 2564, 18, 2176, 7042, 2353, 3857, 1040, 3]}]}
{"query": {"id": "q_1933", "content": "decreased appetite [SEP] nt in the study. Side effects attributable to mazindol included decreased appetite (36%), dry mouth (10%), behavioral change (22%), and gastrointe", "tokenized_content": [2, 3261, 17990, 3, 5891, 1922, 1920, 2161, 18, 4159, 2564, 11081, 1942, 26701, 2762, 1945, 3063, 3261, 17990, 12, 3480, 9, 13, 16, 7143, 11701, 12, 2119, 9, 13, 16, 3]}, "items": [{"id": "p_1933", "content": "Eating Disorders [SEP] A group of disorders characterized by physiological and psychological disturbances in appetite or food intake.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8979, 4414, 3, 43, 2210, 1927, 4414, 4378, 2007, 5005, 1930, 6674, 12654, 1922, 17990, 2014, 3959, 5240, 18, 3]}]}
{"query": {"id": "q_1934", "content": "dry mouth [SEP] cts attributable to mazindol included decreased appetite (36%), dry mouth (10%), behavioral change (22%), and gastrointestinal symptoms (", "tokenized_content": [2, 7143, 11701, 3, 15359, 11081, 1942, 26701, 2762, 1945, 3063, 3261, 17990, 12, 3480, 9, 13, 16, 7143, 11701, 12, 2119, 9, 13, 16, 5343, 3185, 12, 2950, 9, 13, 3]}, "items": [{"id": "p_1934", "content": "Xerostomia [SEP] Decreased salivary flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27833, 28009, 2126, 3, 3261, 11866, 3426, 18, 3]}]}
{"query": {"id": "q_1935", "content": "gastrointestinal symptoms [SEP] d appetite (36%), dry mouth (10%), behavioral change (22%), and gastrointestinal symptoms (18%); mazindol dosage was reduced in 43% of patients. The effe", "tokenized_content": [2, 8375, 3601, 3, 46, 17990, 12, 3480, 9, 13, 16, 7143, 11701, 12, 2119, 9, 13, 16, 5343, 3185, 12, 2950, 9, 13, 16, 1930, 8375, 3601, 12, 2654, 9, 3]}, "items": [{"id": "p_1935", "content": "Signs and Symptoms, Digestive [SEP] Digestive system manifestations of diseases of the gastrointestinal system or of other organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6879, 1930, 3601, 16, 15486, 3, 15486, 2433, 10952, 1927, 3902, 1927, 1920, 8375, 2433, 2014, 1927, 2303, 7393, 18, 3]}]}
{"query": {"id": "q_1936", "content": "Pentoxifylline [SEP] Pentoxifylline (Trental) does not inhibit dipyridamole-induced coronary hypere", "tokenized_content": [2, 9412, 11101, 10196, 2053, 3, 9412, 11101, 10196, 2053, 12, 2171, 4905, 1923, 13, 3731, 2084, 2875, 9137, 3553, 9532, 12492, 1952, 17, 2719, 5846, 24004, 3]}, "items": [{"id": "p_1936", "content": "Pentoxifylline [SEP] A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing ery", "score": 1, "type": null, "tokenized_content": [2, 9412, 11101, 10196, 2053, 3, 43, 4963, 11414, 4905, 7969, 2912, 10533, 1988, 7042, 24821, 1930, 6886, 2877, 8472, 2591, 18, 2176, 10204, 2877, 3426, 2007, 3605, 2668, 1012, 3]}]}
{"query": {"id": "q_1937", "content": "Trental [SEP] Pentoxifylline (Trental) does not inhibit dipyridamole-induced coronary hyperemia: impl", "tokenized_content": [2, 2171, 4905, 1923, 3, 9412, 11101, 10196, 2053, 12, 2171, 4905, 1923, 13, 3731, 2084, 2875, 9137, 3553, 9532, 12492, 1952, 17, 2719, 5846, 24004, 6026, 30, 6313, 3]}, "items": [{"id": "p_1937", "content": "Pentoxifylline [SEP] A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing ery", "score": 1, "type": null, "tokenized_content": [2, 9412, 11101, 10196, 2053, 3, 43, 4963, 11414, 4905, 7969, 2912, 10533, 1988, 7042, 24821, 1930, 6886, 2877, 8472, 2591, 18, 2176, 10204, 2877, 3426, 2007, 3605, 2668, 1012, 3]}]}
{"query": {"id": "q_1938", "content": "dipyridamole [SEP] Pentoxifylline (Trental) does not inhibit dipyridamole-induced coronary hyperemia: implications for dipyridamole-thall", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 9412, 11101, 10196, 2053, 12, 2171, 4905, 1923, 13, 3731, 2084, 2875, 9137, 3553, 9532, 12492, 1952, 17, 2719, 5846, 24004, 6026, 30, 7020, 3]}, "items": [{"id": "p_1938", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_1939", "content": "hyperemia [SEP] ylline (Trental) does not inhibit dipyridamole-induced coronary hyperemia: implications for dipyridamole-thallium-201 myocardial imaging.", "tokenized_content": [2, 24004, 6026, 3, 12111, 3701, 12, 2171, 4905, 1923, 13, 3731, 2084, 2875, 9137, 3553, 9532, 12492, 1952, 17, 2719, 5846, 24004, 6026, 30, 7020, 1958, 9137, 3553, 9532, 12492, 3]}, "items": [{"id": "p_1939", "content": "Hyperemia [SEP] The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. H", "score": 1, "type": null, "tokenized_content": [2, 24004, 6026, 3, 1920, 2990, 1927, 1925, 2502, 4351, 1927, 2877, 1922, 43, 3362, 3131, 2014, 1925, 3090, 4523, 1942, 24053, 2014, 3814, 1924, 2106, 2017, 1927, 2877, 7208, 18, 50, 3]}]}
{"query": {"id": "q_1940", "content": "thallium [SEP] amole-induced coronary hyperemia: implications for dipyridamole-thallium-201 myocardial imaging.", "tokenized_content": [2, 15717, 12191, 1989, 3, 2150, 2456, 17, 2719, 5846, 24004, 6026, 30, 7020, 1958, 9137, 3553, 9532, 12492, 1952, 17, 15717, 12191, 1989, 17, 2262, 6497, 3755, 18, 3]}, "items": [{"id": "p_1940", "content": "Thallium [SEP] A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15717, 12191, 1989, 3, 43, 7881, 16, 2266, 15641, 4511, 6048, 16, 11241, 2529, 6206, 16, 11241, 3388, 37, 16368, 18, 27991, 31, 16368, 18, 25800, 39, 16, 17530, 10474, 18, 3]}]}
{"query": {"id": "q_1941", "content": "Dipyridamole [SEP] Dipyridamole-thallium-201 imaging is often performed in patients unable to e", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 9137, 3553, 9532, 12492, 1952, 17, 15717, 12191, 1989, 17, 2262, 3755, 1977, 3868, 2593, 1922, 2132, 8082, 1942, 47, 3]}, "items": [{"id": "p_1941", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_1942", "content": "thallium [SEP] Dipyridamole-thallium-201 imaging is often performed in patients unable to exercise b", "tokenized_content": [2, 15717, 12191, 1989, 3, 9137, 3553, 9532, 12492, 1952, 17, 15717, 12191, 1989, 17, 2262, 3755, 1977, 3868, 2593, 1922, 2132, 8082, 1942, 4975, 44, 3]}, "items": [{"id": "p_1942", "content": "Thallium [SEP] A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15717, 12191, 1989, 3, 43, 7881, 16, 2266, 15641, 4511, 6048, 16, 11241, 2529, 6206, 16, 11241, 3388, 37, 16368, 18, 27991, 31, 16368, 18, 25800, 39, 16, 17530, 10474, 18, 3]}]}
{"query": {"id": "q_1943", "content": "peripheral vascular disease [SEP] ng is often performed in patients unable to exercise because of peripheral vascular disease. Many of these patients are taking pentoxifylline (Trental), a ", "tokenized_content": [2, 5009, 4541, 2573, 3, 4375, 1977, 3868, 2593, 1922, 2132, 8082, 1942, 4975, 2882, 1927, 5009, 4541, 2573, 18, 3086, 1927, 2144, 2132, 2032, 6303, 9412, 11101, 10196, 2053, 12, 3]}, "items": [{"id": "p_1943", "content": "Peripheral Vascular Diseases [SEP] Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5009, 4541, 3902, 3, 6598, 4028, 5884, 2967, 2340, 1927, 1920, 2877, 7208, 1922, 1920, 13040, 7008, 1920, 4003, 18, 3]}]}
{"query": {"id": "q_1944", "content": "pentoxifylline [SEP]  peripheral vascular disease. Many of these patients are taking pentoxifylline (Trental), a methylxanthine derivative which may improve interm", "tokenized_content": [2, 9412, 11101, 10196, 2053, 3, 5009, 4541, 2573, 18, 3086, 1927, 2144, 2132, 2032, 6303, 9412, 11101, 10196, 2053, 12, 2171, 4905, 1923, 13, 16, 43, 4963, 11414, 4905, 7969, 3]}, "items": [{"id": "p_1944", "content": "Pentoxifylline [SEP] A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing ery", "score": 1, "type": null, "tokenized_content": [2, 9412, 11101, 10196, 2053, 3, 43, 4963, 11414, 4905, 7969, 2912, 10533, 1988, 7042, 24821, 1930, 6886, 2877, 8472, 2591, 18, 2176, 10204, 2877, 3426, 2007, 3605, 2668, 1012, 3]}]}
{"query": {"id": "q_1945", "content": "Trental [SEP] ular disease. Many of these patients are taking pentoxifylline (Trental), a methylxanthine derivative which may improve intermittent cl", "tokenized_content": [2, 2171, 4905, 1923, 3, 3570, 1933, 2573, 18, 3086, 1927, 2144, 2132, 2032, 6303, 9412, 11101, 10196, 2053, 12, 2171, 4905, 1923, 13, 16, 43, 4963, 11414, 4905, 7969, 2912, 3]}, "items": [{"id": "p_1945", "content": "Pentoxifylline [SEP] A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing ery", "score": 1, "type": null, "tokenized_content": [2, 9412, 11101, 10196, 2053, 3, 43, 4963, 11414, 4905, 7969, 2912, 10533, 1988, 7042, 24821, 1930, 6886, 2877, 8472, 2591, 18, 2176, 10204, 2877, 3426, 2007, 3605, 2668, 1012, 3]}]}
{"query": {"id": "q_1946", "content": "methylxanthine [SEP] . Many of these patients are taking pentoxifylline (Trental), a methylxanthine derivative which may improve intermittent claudication. Whether", "tokenized_content": [2, 4963, 11414, 4905, 7969, 2912, 3, 18, 3086, 1927, 2144, 2132, 2032, 6303, 9412, 11101, 10196, 2053, 12, 2171, 4905, 1923, 13, 16, 43, 4963, 11414, 4905, 7969, 2912, 10533, 3]}, "items": [{"id": "p_1946", "content": "methylxanthine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4963, 11414, 4905, 7969, 2912, 3, 3]}]}
{"query": {"id": "q_1947", "content": "intermittent claudication [SEP] ylline (Trental), a methylxanthine derivative which may improve intermittent claudication. Whether pentoxifylline inhibits dipyridamole-induced coronary ", "tokenized_content": [2, 13252, 27094, 2959, 3, 12111, 3701, 12, 2171, 4905, 1923, 13, 16, 43, 4963, 11414, 4905, 7969, 2912, 10533, 2154, 2278, 3326, 13252, 27094, 2959, 18, 3053, 9412, 11101, 10196, 3]}, "items": [{"id": "p_1947", "content": "Intermittent Claudication [SEP] A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and wea", "score": 1, "type": null, "tokenized_content": [2, 13252, 27094, 2959, 3, 43, 3226, 2796, 4378, 2007, 3594, 1930, 12175, 1922, 7345, 3760, 2210, 2458, 1956, 4975, 16, 2427, 1966, 6703, 3594, 1930, 2038, 1019, 3]}]}
{"query": {"id": "q_1948", "content": "dipyridamole [SEP] rove intermittent claudication. Whether pentoxifylline inhibits dipyridamole-induced coronary hyperemia like other methylxanthines such as t", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 3039, 1961, 13252, 27094, 2959, 18, 3053, 9412, 11101, 10196, 2053, 7042, 9137, 3553, 9532, 12492, 1952, 17, 2719, 5846, 24004, 6026, 3189, 2303, 3]}, "items": [{"id": "p_1948", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_1949", "content": "hyperemia [SEP] . Whether pentoxifylline inhibits dipyridamole-induced coronary hyperemia like other methylxanthines such as theophylline and should be s", "tokenized_content": [2, 24004, 6026, 3, 18, 3053, 9412, 11101, 10196, 2053, 7042, 9137, 3553, 9532, 12492, 1952, 17, 2719, 5846, 24004, 6026, 3189, 2303, 4963, 11414, 4905, 7969, 11682, 2427, 1966, 29629, 3]}, "items": [{"id": "p_1949", "content": "Hyperemia [SEP] The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. H", "score": 1, "type": null, "tokenized_content": [2, 24004, 6026, 3, 1920, 2990, 1927, 1925, 2502, 4351, 1927, 2877, 1922, 43, 3362, 3131, 2014, 1925, 3090, 4523, 1942, 24053, 2014, 3814, 1924, 2106, 2017, 1927, 2877, 7208, 18, 50, 3]}]}
{"query": {"id": "q_1950", "content": "methylxanthines [SEP] ine inhibits dipyridamole-induced coronary hyperemia like other methylxanthines such as theophylline and should be stopped prior to dipyridamol", "tokenized_content": [2, 4963, 11414, 4905, 7969, 11682, 3, 11116, 7042, 9137, 3553, 9532, 12492, 1952, 17, 2719, 5846, 24004, 6026, 3189, 2303, 4963, 11414, 4905, 7969, 11682, 2427, 1966, 29629, 1930, 3066, 3]}, "items": [{"id": "p_1950", "content": "methylxanthine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4963, 11414, 4905, 7969, 2912, 3, 3]}]}
{"query": {"id": "q_1951", "content": "theophylline [SEP] e-induced coronary hyperemia like other methylxanthines such as theophylline and should be stopped prior to dipyridamole-thallium-201 imagin", "tokenized_content": [2, 29629, 3, 47, 17, 2719, 5846, 24004, 6026, 3189, 2303, 4963, 11414, 4905, 7969, 11682, 2427, 1966, 29629, 1930, 3066, 1998, 12032, 3432, 1942, 9137, 3553, 9532, 12492, 1952, 17, 3]}, "items": [{"id": "p_1951", "content": "Theophylline [SEP] A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous sys", "score": 1, "type": null, "tokenized_content": [2, 29629, 3, 43, 4963, 26059, 10533, 2037, 12459, 1956, 26829, 16, 6689, 3760, 7327, 2031, 16, 14700, 16470, 16, 4435, 1930, 4101, 7580, 7930, 1036, 3]}]}
{"query": {"id": "q_1952", "content": "pentoxyifylline [SEP] y lower after theophylline (p less than 0.01). We conclude that pentoxyifylline does not inhibit dipyridamole-induced coronary hyperemia even a", "tokenized_content": [2, 9412, 7221, 5169, 11560, 2053, 3, 67, 2826, 2256, 29629, 12, 58, 2941, 2254, 20, 18, 3287, 13, 18, 2038, 7676, 1988, 9412, 7221, 5169, 11560, 2053, 3731, 2084, 2875, 3]}, "items": [{"id": "p_1952", "content": "Pentoxifylline [SEP] A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing ery", "score": 1, "type": null, "tokenized_content": [2, 9412, 11101, 10196, 2053, 3, 43, 4963, 11414, 4905, 7969, 2912, 10533, 1988, 7042, 24821, 1930, 6886, 2877, 8472, 2591, 18, 2176, 10204, 2877, 3426, 2007, 3605, 2668, 1012, 3]}]}
{"query": {"id": "q_1953", "content": "death [SEP] Cause of death among patients with Parkinson's disease: a rare mortality due t", "tokenized_content": [2, 3539, 3, 3936, 1927, 3539, 2706, 2132, 1956, 10124, 11, 61, 2573, 30, 43, 5844, 3885, 2810, 62, 3]}, "items": [{"id": "p_1953", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_1954", "content": "Parkinson's disease [SEP] Cause of death among patients with Parkinson's disease: a rare mortality due to cerebral haemorrhage.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 3936, 1927, 3539, 2706, 2132, 1956, 10124, 11, 61, 2573, 30, 43, 5844, 3885, 2810, 1942, 6329, 23352, 18, 3]}, "items": [{"id": "p_1954", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1955", "content": "cerebral haemorrhage [SEP] mong patients with Parkinson's disease: a rare mortality due to cerebral haemorrhage.", "tokenized_content": [2, 6329, 23352, 3, 23659, 2132, 1956, 10124, 11, 61, 2573, 30, 43, 5844, 3885, 2810, 1942, 6329, 23352, 18, 3]}, "items": [{"id": "p_1955", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_1956", "content": "death [SEP] Causes of death, with special reference to cerebral haemorrhage, among 240 pati", "tokenized_content": [2, 3539, 3, 5092, 1927, 3539, 16, 1956, 5180, 4386, 1942, 6329, 23352, 16, 2706, 12075, 2091, 3]}, "items": [{"id": "p_1956", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_1957", "content": "cerebral haemorrhage [SEP] Causes of death, with special reference to cerebral haemorrhage, among 240 patients with pathologically verified Parkinson's di", "tokenized_content": [2, 6329, 23352, 3, 5092, 1927, 3539, 16, 1956, 5180, 4386, 1942, 6329, 23352, 16, 2706, 12075, 2132, 1956, 24547, 8759, 10124, 11, 61, 2137, 3]}, "items": [{"id": "p_1957", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_1958", "content": "Parkinson's disease [SEP] al haemorrhage, among 240 patients with pathologically verified Parkinson's disease were investigated using the Annuals of the Pathological Autopsy", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 1969, 23352, 16, 2706, 12075, 2132, 1956, 24547, 8759, 10124, 11, 61, 2573, 1985, 3845, 2193, 1920, 7780, 1036, 1927, 1920, 6598, 16740, 3]}, "items": [{"id": "p_1958", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1959", "content": "pneumonia [SEP] es in Japan from 1981 to 1985. The leading causes of death were pneumonia and bronchitis (44.1%), malignant neoplasms (11.6%), heart dise", "tokenized_content": [2, 7868, 3, 2376, 1922, 5834, 2037, 14661, 1942, 11917, 18, 1920, 4523, 5092, 1927, 3539, 1985, 7868, 1930, 28938, 12, 4044, 18, 21, 9, 13, 16, 6558, 15347, 12, 2513, 3]}, "items": [{"id": "p_1959", "content": "Pneumonia [SEP] Inflammation of any part, segment or lobe, of the lung parenchyma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7868, 3, 4531, 1927, 2967, 3131, 16, 5367, 2014, 9581, 16, 1927, 1920, 3614, 15214, 18, 3]}]}
{"query": {"id": "q_1960", "content": "bronchitis [SEP] om 1981 to 1985. The leading causes of death were pneumonia and bronchitis (44.1%), malignant neoplasms (11.6%), heart diseases (4.1%), ce", "tokenized_content": [2, 28938, 3, 7254, 14661, 1942, 11917, 18, 1920, 4523, 5092, 1927, 3539, 1985, 7868, 1930, 28938, 12, 4044, 18, 21, 9, 13, 16, 6558, 15347, 12, 2513, 18, 26, 9, 3]}, "items": [{"id": "p_1960", "content": "Bronchitis [SEP] Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCH", "score": 1, "type": null, "tokenized_content": [2, 28938, 3, 4531, 1927, 1920, 3103, 16180, 1922, 1920, 3614, 2710, 2967, 3131, 1927, 1920, 20431, 16, 2037, 1920, 3065, 20431, 1942, 1920, 10832, 7777, 3]}]}
{"query": {"id": "q_1961", "content": "neoplasms [SEP] auses of death were pneumonia and bronchitis (44.1%), malignant neoplasms (11.6%), heart diseases (4.1%), cerebral infarction (3.7%) and ", "tokenized_content": [2, 15347, 3, 18238, 1918, 1927, 3539, 1985, 7868, 1930, 28938, 12, 4044, 18, 21, 9, 13, 16, 6558, 15347, 12, 2513, 18, 26, 9, 13, 16, 4003, 3902, 12, 24, 3]}, "items": [{"id": "p_1961", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_1962", "content": "heart diseases [SEP]  pneumonia and bronchitis (44.1%), malignant neoplasms (11.6%), heart diseases (4.1%), cerebral infarction (3.7%) and septicaemia (3.3%). Cere", "tokenized_content": [2, 4003, 3902, 3, 7868, 1930, 28938, 12, 4044, 18, 21, 9, 13, 16, 6558, 15347, 12, 2513, 18, 26, 9, 13, 16, 4003, 3902, 12, 24, 18, 21, 9, 13, 3]}, "items": [{"id": "p_1962", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_1963", "content": "cerebral infarction [SEP] is (44.1%), malignant neoplasms (11.6%), heart diseases (4.1%), cerebral infarction (3.7%) and septicaemia (3.3%). Cerebral haemorrhage was the 11t", "tokenized_content": [2, 6329, 8358, 3, 1977, 12, 4044, 18, 21, 9, 13, 16, 6558, 15347, 12, 2513, 18, 26, 9, 13, 16, 4003, 3902, 12, 24, 18, 21, 9, 13, 16, 6329, 3]}, "items": [{"id": "p_1963", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_1964", "content": "septicaemia [SEP]  (11.6%), heart diseases (4.1%), cerebral infarction (3.7%) and septicaemia (3.3%). Cerebral haemorrhage was the 11th most frequent cause o", "tokenized_content": [2, 13927, 12392, 3, 12, 2513, 18, 26, 9, 13, 16, 4003, 3902, 12, 24, 18, 21, 9, 13, 16, 6329, 8358, 12, 23, 18, 27, 9, 13, 1930, 13927, 12392, 3]}, "items": [{"id": "p_1964", "content": "Sepsis [SEP] Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dys", "score": 1, "type": null, "tokenized_content": [2, 9019, 3, 5510, 3769, 2644, 4741, 1956, 43, 9253, 2014, 9407, 7465, 10383, 18, 2469, 9019, 1977, 2458, 1956, 3090, 3890, 3]}]}
{"query": {"id": "q_1965", "content": "Cerebral haemorrhage [SEP] ases (4.1%), cerebral infarction (3.7%) and septicaemia (3.3%). Cerebral haemorrhage was the 11th most frequent cause of death, accounting for only ", "tokenized_content": [2, 6329, 23352, 3, 28826, 1036, 12, 24, 18, 21, 9, 13, 16, 6329, 8358, 12, 23, 18, 27, 9, 13, 1930, 13927, 12392, 12, 23, 18, 23, 9, 13, 18, 3]}, "items": [{"id": "p_1965", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_1966", "content": "deaths [SEP]  11th most frequent cause of death, accounting for only 0.8% of deaths among the patients, whereas it was the 5th most common cause of", "tokenized_content": [2, 7601, 3, 2513, 1963, 2501, 6439, 3936, 1927, 3539, 16, 10919, 1958, 2444, 20, 18, 28, 9, 1927, 7601, 2706, 1920, 2132, 16, 3417, 2176, 1982, 1920, 17853, 2501, 3059, 3]}, "items": [{"id": "p_1966", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_1967", "content": "hypotensive [SEP] e of death in patients with Parkinson's disease may reflect the hypotensive effect of levodopa and a hypotensive mechanism due to reduced n", "tokenized_content": [2, 12201, 3766, 3, 47, 1927, 3539, 1922, 2132, 1956, 10124, 11, 61, 2573, 2278, 5840, 1920, 12201, 3766, 2495, 1927, 26723, 1930, 43, 12201, 3766, 2856, 2810, 1942, 3028, 56, 3]}, "items": [{"id": "p_1967", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1968", "content": "levodopa [SEP]  with Parkinson's disease may reflect the hypotensive effect of levodopa and a hypotensive mechanism due to reduced noradrenaline levels", "tokenized_content": [2, 26723, 3, 1956, 10124, 11, 61, 2573, 2278, 5840, 1920, 12201, 3766, 2495, 1927, 26723, 1930, 43, 12201, 3766, 2856, 2810, 1942, 3028, 22636, 2428, 3]}, "items": [{"id": "p_1968", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_1969", "content": "noradrenaline [SEP] e effect of levodopa and a hypotensive mechanism due to reduced noradrenaline levels in the parkinsonian brain.", "tokenized_content": [2, 22636, 3, 47, 2495, 1927, 26723, 1930, 43, 12201, 3766, 2856, 2810, 1942, 3028, 22636, 2428, 1922, 1920, 10124, 3122, 3068, 18, 3]}, "items": [{"id": "p_1969", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_1970", "content": "parkinsonian [SEP] ypotensive mechanism due to reduced noradrenaline levels in the parkinsonian brain.", "tokenized_content": [2, 10124, 3122, 3, 21995, 7229, 3355, 2320, 2856, 2810, 1942, 3028, 22636, 2428, 1922, 1920, 10124, 3122, 3068, 18, 3]}, "items": [{"id": "p_1970", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_1971", "content": "ribavirin [SEP] Tolerance and antiviral effect of ribavirin in patients with Argentine hemorrhagic fever.", "tokenized_content": [2, 23635, 3, 6555, 1930, 10129, 2495, 1927, 23635, 1922, 2132, 1956, 23015, 2912, 16052, 9087, 18, 3]}, "items": [{"id": "p_1971", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1972", "content": "Argentine hemorrhagic fever [SEP] Tolerance and antiviral effect of ribavirin in patients with Argentine hemorrhagic fever.", "tokenized_content": [2, 23015, 2912, 16052, 9087, 3, 6555, 1930, 10129, 2495, 1927, 23635, 1922, 2132, 1956, 23015, 2912, 16052, 9087, 18, 3]}, "items": [{"id": "p_1972", "content": "Hemorrhagic Fever, American [SEP] Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).\n    ", "score": 1, "type": null, "tokenized_content": [2, 16052, 9087, 16, 5339, 3, 3902, 4189, 2007, 5339, 16052, 9087, 6241, 12, 23365, 15506, 16, 2814, 4867, 13, 18, 3]}]}
{"query": {"id": "q_1973", "content": "ribavirin [SEP] Tolerance and antiviral effect of ribavirin was studied in 6 patients with Argentine hemorrhagic fever (AHF", "tokenized_content": [2, 23635, 3, 6555, 1930, 10129, 2495, 1927, 23635, 1982, 3942, 1922, 26, 2132, 1956, 23015, 2912, 16052, 9087, 12, 9646, 1038, 3]}, "items": [{"id": "p_1973", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_1974", "content": "Argentine hemorrhagic fever [SEP] nd antiviral effect of ribavirin was studied in 6 patients with Argentine hemorrhagic fever (AHF) of more than 8 days of evolution. Administration of ribav", "tokenized_content": [2, 23015, 2912, 16052, 9087, 3, 8026, 10129, 2495, 1927, 23635, 1982, 3942, 1922, 26, 2132, 1956, 23015, 2912, 16052, 9087, 12, 9646, 1038, 13, 1927, 2253, 2254, 28, 3000, 1927, 3]}, "items": [{"id": "p_1974", "content": "Hemorrhagic Fever, American [SEP] Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).\n    ", "score": 1, "type": null, "tokenized_content": [2, 16052, 9087, 16, 5339, 3, 3902, 4189, 2007, 5339, 16052, 9087, 6241, 12, 23365, 15506, 16, 2814, 4867, 13, 18, 3]}]}
{"query": {"id": "q_1975", "content": "AHF [SEP] rin was studied in 6 patients with Argentine hemorrhagic fever (AHF) of more than 8 days of evolution. Administration of ribavirin ", "tokenized_content": [2, 9646, 1038, 3, 25699, 1982, 3942, 1922, 26, 2132, 1956, 23015, 2912, 16052, 9087, 12, 9646, 1038, 13, 1927, 2253, 2254, 28, 3000, 1927, 4854, 18, 4183, 1927, 23635, 3]}, "items": [{"id": "p_1975", "content": "Hemorrhagic Fever, American [SEP] Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).\n    ", "score": 1, "type": null, "tokenized_content": [2, 16052, 9087, 16, 5339, 3, 3902, 4189, 2007, 5339, 16052, 9087, 6241, 12, 23365, 15506, 16, 2814, 4867, 13, 18, 3]}]}
{"query": {"id": "q_1976", "content": "viremia [SEP] on. Administration of ribavirin resulted in a neutralization of viremia and a drop of endogenous interferon titers. The average time of", "tokenized_content": [2, 22360, 3, 1990, 18, 4183, 1927, 23635, 4306, 1922, 43, 14377, 1927, 22360, 1930, 43, 7086, 1927, 5355, 10001, 11184, 18, 1920, 3361, 2367, 1927, 3]}, "items": [{"id": "p_1976", "content": "Viremia [SEP] The presence of viruses in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 22360, 3, 1920, 2990, 1927, 6241, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_1977", "content": "death [SEP] and a drop of endogenous interferon titers. The average time of death was delayed. A reversible anemia was the only adverse effect ob", "tokenized_content": [2, 3539, 3, 1930, 43, 7086, 1927, 5355, 10001, 11184, 18, 1920, 3361, 2367, 1927, 3539, 1982, 7083, 18, 43, 10743, 10679, 1982, 1920, 2444, 5246, 2495, 2384, 3]}, "items": [{"id": "p_1977", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_1978", "content": "anemia [SEP] ron titers. The average time of death was delayed. A reversible anemia was the only adverse effect observed. From these results, we co", "tokenized_content": [2, 10679, 3, 25851, 11184, 18, 1920, 3361, 2367, 1927, 3539, 1982, 7083, 18, 43, 10743, 10679, 1982, 1920, 2444, 5246, 2495, 2528, 18, 2037, 2144, 2274, 16, 2038, 2081, 3]}, "items": [{"id": "p_1978", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_1979", "content": "Dipyridamole [SEP] Dipyridamole-induced myocardial ischemia.", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 9137, 3553, 9532, 12492, 1952, 17, 2719, 6497, 7716, 18, 3]}, "items": [{"id": "p_1979", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_1980", "content": "myocardial ischemia [SEP] Dipyridamole-induced myocardial ischemia.", "tokenized_content": [2, 6497, 7716, 3, 9137, 3553, 9532, 12492, 1952, 17, 2719, 6497, 7716, 18, 3]}, "items": [{"id": "p_1980", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_1981", "content": "Angina [SEP] Angina and ischemic electrocardiographic changes occurred after admini", "tokenized_content": [2, 16961, 3, 16961, 1930, 7427, 15894, 4158, 2840, 4807, 2256, 3318, 1033, 3]}, "items": [{"id": "p_1981", "content": "Angina Pectoris [SEP] The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 3, 1920, 3226, 1927, 28033, 3594, 16693, 1942, 6497, 7716, 5394, 1927, 15308, 2728, 16, 5185, 1930, 5442, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_1982", "content": "dipyridamole [SEP] ctrocardiographic changes occurred after administration of oral dipyridamole in four patients awaiting urgent myocardial revascularization p", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 13033, 9641, 4158, 2840, 4807, 2256, 4183, 1927, 4726, 9137, 3553, 9532, 12492, 1952, 1922, 3006, 2132, 21108, 3658, 15210, 6497, 17054, 58, 3]}, "items": [{"id": "p_1982", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_1983", "content": "myocardial ischemia [SEP] reoperative dipyridamole therapy, although dipyridamole-induced myocardial ischemia has been demonstrated to occur in animals and humans with coron", "tokenized_content": [2, 6497, 7716, 3, 21914, 2178, 9137, 3553, 9532, 12492, 1952, 3181, 16, 2876, 9137, 3553, 9532, 12492, 1952, 17, 2719, 6497, 7716, 2258, 2252, 3161, 1942, 4704, 1922, 3555, 1930, 3]}, "items": [{"id": "p_1983", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_1984", "content": "coronary artery disease [SEP] hemia has been demonstrated to occur in animals and humans with coronary artery disease. Epicardial coronary collateral vessels were demonstrated in al", "tokenized_content": [2, 5846, 5511, 2573, 3, 28881, 1019, 2258, 2252, 3161, 1942, 4704, 1922, 3555, 1930, 5209, 1956, 5846, 5511, 2573, 18, 22568, 5846, 18022, 7208, 1985, 3161, 1922, 1969, 3]}, "items": [{"id": "p_1984", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_1985", "content": "ischemia [SEP]  dipyridamole therapy, although dipyridamole-induced myocardial ischemia has been demonstrated to occur in animals and humans with coron", "tokenized_content": [2, 7716, 3, 9137, 3553, 9532, 12492, 1952, 3181, 16, 2876, 9137, 3553, 9532, 12492, 1952, 17, 2719, 6497, 7716, 2258, 2252, 3161, 1942, 4704, 1922, 3555, 1930, 5209, 1956, 5548, 3]}, "items": [{"id": "p_1985", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_1986", "content": "Nitroprusside [SEP] Nitroprusside-induced hypotension evokes ACTH secretion which is primarily me", "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 8686, 2047, 3468, 2261, 17, 2719, 16453, 24074, 1036, 16287, 5512, 2154, 1977, 5985, 2142, 3]}, "items": [{"id": "p_1986", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_1987", "content": "hypotension [SEP] Nitroprusside-induced hypotension evokes ACTH secretion which is primarily mediated by enhanced s", "tokenized_content": [2, 16453, 3, 8686, 2047, 3468, 2261, 17, 2719, 16453, 24074, 1036, 16287, 5512, 2154, 1977, 5985, 3434, 2007, 4256, 61, 3]}, "items": [{"id": "p_1987", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_1988", "content": "arginine vasopressin [SEP] ial-portal circulation. Portal plasma concentrations of neither arginine vasopressin nor oxytocin are significantly altered in this paradigm. Applic", "tokenized_content": [2, 9732, 20671, 3, 11640, 1024, 17, 10669, 9255, 18, 10669, 3582, 3295, 1927, 7132, 9732, 20671, 3990, 17775, 2032, 2567, 5520, 1922, 2052, 9930, 18, 7973, 3]}, "items": [{"id": "p_1988", "content": "Arginine Vasopressin [SEP] The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfid", "score": 1, "type": null, "tokenized_content": [2, 9732, 20671, 3, 1920, 6136, 2386, 1927, 6492, 22576, 15766, 6365, 18, 2176, 1977, 43, 2447, 24010, 3165, 1925, 9732, 2019, 6181, 28, 1930, 2288, 10993, 1960, 3]}]}
{"query": {"id": "q_1989", "content": "oxytocin [SEP] ortal plasma concentrations of neither arginine vasopressin nor oxytocin are significantly altered in this paradigm. Application of a de", "tokenized_content": [2, 17775, 3, 2014, 2381, 3582, 3295, 1927, 7132, 9732, 20671, 3990, 17775, 2032, 2567, 5520, 1922, 2052, 9930, 18, 4722, 1927, 43, 2028, 3]}, "items": [{"id": "p_1989", "content": "Oxytocin [SEP] A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino a", "score": 1, "type": null, "tokenized_content": [2, 17775, 3, 43, 2447, 24010, 6365, 6988, 2037, 1920, 3366, 30338, 7056, 25818, 8362, 12, 10621, 8359, 16, 5545, 13, 18, 2176, 11457, 2037, 20671, 2007, 2288, 3835, 43, 3]}]}
{"query": {"id": "q_1990", "content": "corticosterone [SEP] ion of a delayed feedback signal, in the form of a 2-h systemic corticosterone infusion in urethane-anesthetized rats with pharmacological blo", "tokenized_content": [2, 18136, 3, 4755, 1927, 43, 7083, 6491, 2733, 16, 1922, 1920, 2386, 1927, 43, 22, 17, 50, 5510, 18136, 7386, 1922, 19221, 2516, 17, 12137, 3615, 1956, 7683, 16635, 3]}, "items": [{"id": "p_1990", "content": "Corticosterone [SEP] An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman ", "score": 1, "type": null, "tokenized_content": [2, 18136, 3, 1925, 7206, 16557, 9507, 1988, 2258, 9194, 2308, 2228, 4209, 1966, 43, 8463, 10323, 2642, 1930, 43, 14469, 18, 12, 2037, 4227, 3862, 3]}]}
{"query": {"id": "q_1991", "content": "urethane [SEP] ignal, in the form of a 2-h systemic corticosterone infusion in urethane-anesthetized rats with pharmacological blockade of glucocortico", "tokenized_content": [2, 19221, 2516, 3, 12046, 1923, 16, 1922, 1920, 2386, 1927, 43, 22, 17, 50, 5510, 18136, 7386, 1922, 19221, 2516, 17, 12137, 3615, 1956, 7683, 9847, 1927, 11336, 1037, 3]}, "items": [{"id": "p_1991", "content": "Urethane [SEP] Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis", "score": 1, "type": null, "tokenized_content": [2, 19221, 2516, 3, 29128, 9969, 5899, 1988, 1977, 2222, 2251, 1966, 43, 15748, 16111, 18, 2176, 2258, 2222, 2252, 2251, 1966, 1925, 6129, 1922, 6805, 4271, 3]}]}
{"query": {"id": "q_1992", "content": "nitroprusside [SEP] 40 micrograms/dl. Suppression of irCRF secretion in response to nitroprusside-induced hypotension is observed and occurs at a plasma corticos", "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 3040, 13362, 19, 5268, 18, 6412, 1927, 3166, 2145, 1038, 5512, 1922, 2644, 1942, 8686, 2047, 3468, 2261, 17, 2719, 16453, 1977, 2528, 1930, 5110, 3]}, "items": [{"id": "p_1992", "content": "Nitroprusside [SEP] A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for f", "score": 1, "type": null, "tokenized_content": [2, 8686, 2047, 3468, 2261, 3, 43, 9974, 28194, 2251, 1922, 14569, 15895, 2062, 1942, 2826, 2877, 3772, 2014, 1942, 3326, 4435, 2347, 18, 2176, 1977, 2222, 1925, 8413, 1958, 48, 3]}]}
{"query": {"id": "q_1993", "content": "catalepsy [SEP] Noradrenergic involvement in catalepsy induced by delta 9-tetrahydrocannabinol.", "tokenized_content": [2, 4233, 9431, 1012, 3, 27358, 5668, 1922, 4233, 9431, 1012, 2719, 2007, 9649, 29, 17, 21196, 8337, 2175, 23605, 1945, 18, 3]}, "items": [{"id": "p_1993", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_1994", "content": "delta 9-tetrahydrocannabinol [SEP] Noradrenergic involvement in catalepsy induced by delta 9-tetrahydrocannabinol.", "tokenized_content": [2, 9649, 29, 17, 21196, 8337, 2175, 23605, 1945, 3, 27358, 5668, 1922, 4233, 9431, 1012, 2719, 2007, 9649, 29, 17, 21196, 8337, 2175, 23605, 1945, 18, 3]}, "items": [{"id": "p_1994", "content": "Dronabinol [SEP] A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabino", "score": 1, "type": null, "tokenized_content": [2, 8442, 2175, 23605, 1945, 3, 43, 18740, 3849, 3547, 5210, 2037, 1920, 10441, 1927, 14664, 22939, 12, 13081, 24315, 7241, 16, 25394, 2471, 13, 18, 1920, 15348, 9649, 17, 29, 17, 21196, 8337, 2175, 23605, 1037, 3]}]}
{"query": {"id": "q_1995", "content": "delta 9-tetrahydrocannabinol [SEP] of the catecholaminergic system in the cataleptogenic effect of delta 9-tetrahydrocannabinol (THC), the effect of pretreatment with 6-hydroxydopamine (6-OHD", "tokenized_content": [2, 9649, 29, 17, 21196, 8337, 2175, 23605, 1945, 3, 1927, 1920, 23483, 1005, 11545, 2433, 1922, 1920, 4233, 7344, 3880, 2495, 1927, 9649, 29, 17, 21196, 8337, 2175, 23605, 1945, 3]}, "items": [{"id": "p_1995", "content": "Dronabinol [SEP] A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabino", "score": 1, "type": null, "tokenized_content": [2, 8442, 2175, 23605, 1945, 3, 43, 18740, 3849, 3547, 5210, 2037, 1920, 10441, 1927, 14664, 22939, 12, 13081, 24315, 7241, 16, 25394, 2471, 13, 18, 1920, 15348, 9649, 17, 29, 17, 21196, 8337, 2175, 23605, 1037, 3]}]}
{"query": {"id": "q_1996", "content": "THC [SEP] m in the cataleptogenic effect of delta 9-tetrahydrocannabinol (THC), the effect of pretreatment with 6-hydroxydopamine (6-OHDA) or", "tokenized_content": [2, 19925, 3, 55, 1922, 1920, 4233, 7344, 3880, 2495, 1927, 9649, 29, 17, 21196, 8337, 2175, 23605, 1945, 12, 19925, 13, 16, 1920, 2495, 1927, 9111, 1956, 26, 17, 8275, 3]}, "items": [{"id": "p_1996", "content": "Dronabinol [SEP] A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabino", "score": 1, "type": null, "tokenized_content": [2, 8442, 2175, 23605, 1945, 3, 43, 18740, 3849, 3547, 5210, 2037, 1920, 10441, 1927, 14664, 22939, 12, 13081, 24315, 7241, 16, 25394, 2471, 13, 18, 1920, 15348, 9649, 17, 29, 17, 21196, 8337, 2175, 23605, 1037, 3]}]}
{"query": {"id": "q_1997", "content": "6-hydroxydopamine [SEP] a 9-tetrahydrocannabinol (THC), the effect of pretreatment with 6-hydroxydopamine (6-OHDA) or with desipramine and 6-OHDA and lesions of the locu", "tokenized_content": [2, 26, 17, 8275, 22389, 4302, 25157, 3, 43, 29, 17, 21196, 8337, 2175, 23605, 1945, 12, 19925, 13, 16, 1920, 2495, 1927, 9111, 1956, 26, 17, 8275, 22389, 4302, 25157, 3]}, "items": [{"id": "p_1997", "content": "Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th", "score": 1, "type": null, "tokenized_content": [2, 3618, 8228, 25157, 3, 43, 15223, 12980, 1988, 27287, 1036, 27358, 14846, 1922, 5507, 17970, 1036, 1930, 6387, 43, 3378, 1927, 7964, 2428, 1922, 1913, 3]}]}
{"query": {"id": "q_1998", "content": "6-OHDA [SEP] binol (THC), the effect of pretreatment with 6-hydroxydopamine (6-OHDA) or with desipramine and 6-OHDA and lesions of the locus coerul", "tokenized_content": [2, 26, 17, 25737, 3, 8768, 1945, 12, 19925, 13, 16, 1920, 2495, 1927, 9111, 1956, 26, 17, 8275, 22389, 4302, 25157, 12, 26, 17, 25737, 13, 2014, 1956, 2270, 27085, 3]}, "items": [{"id": "p_1998", "content": "Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th", "score": 1, "type": null, "tokenized_content": [2, 3618, 8228, 25157, 3, 43, 15223, 12980, 1988, 27287, 1036, 27358, 14846, 1922, 5507, 17970, 1036, 1930, 6387, 43, 3378, 1927, 7964, 2428, 1922, 1913, 3]}]}
{"query": {"id": "q_1999", "content": "desipramine [SEP]  effect of pretreatment with 6-hydroxydopamine (6-OHDA) or with desipramine and 6-OHDA and lesions of the locus coeruleus were investigated", "tokenized_content": [2, 2270, 27085, 3, 2495, 1927, 9111, 1956, 26, 17, 8275, 22389, 4302, 25157, 12, 26, 17, 25737, 13, 2014, 1956, 2270, 27085, 1930, 26, 17, 25737, 1930, 4518, 1927, 1920, 3]}, "items": [{"id": "p_1999", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_2000", "content": "haloperidol [SEP] ith control rats. On the contrary, the cataleptogenic effect of haloperidol was significantly reduced in rats treated with desipramine and ", "tokenized_content": [2, 25107, 3, 24737, 2285, 3615, 18, 1990, 1920, 10346, 16, 1920, 4233, 7344, 3880, 2495, 1927, 25107, 1982, 2567, 3028, 1922, 3615, 2868, 1956, 2270, 27085, 1930, 3]}, "items": [{"id": "p_2000", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_2001", "content": "catalepsy [SEP] renergic neurons have an important role in the manifestation of catalepsy induced by THC, whereas dopaminergic neurons are important in c", "tokenized_content": [2, 4233, 9431, 1012, 3, 3866, 5237, 3558, 2162, 1925, 2715, 2770, 1922, 1920, 15570, 1927, 4233, 9431, 1012, 2719, 2007, 19925, 16, 3417, 12214, 3558, 2032, 2715, 1922, 45, 3]}, "items": [{"id": "p_2001", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_2002", "content": "alfentanil [SEP] Intracranial pressure increases during alfentanil-induced rigidity.", "tokenized_content": [2, 17913, 25722, 3, 12179, 3772, 4041, 2409, 17913, 25722, 17, 2719, 20471, 18, 3]}, "items": [{"id": "p_2002", "content": "Alfentanil [SEP] A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recov", "score": 1, "type": null, "tokenized_content": [2, 17913, 25722, 3, 43, 3662, 17, 8290, 9384, 16111, 1930, 14501, 10533, 1927, 20311, 18, 2176, 9300, 1925, 3120, 3833, 14501, 2495, 1930, 5867, 29326, 1020, 3]}]}
{"query": {"id": "q_2003", "content": "rigidity [SEP] Intracranial pressure increases during alfentanil-induced rigidity.", "tokenized_content": [2, 20471, 3, 12179, 3772, 4041, 2409, 17913, 25722, 17, 2719, 20471, 18, 3]}, "items": [{"id": "p_2003", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_2004", "content": "alfentanil [SEP] Intracranial pressure (ICP) was measured during alfentanil-induced rigidity in rats. Ten rats had arterial, central venous", "tokenized_content": [2, 17913, 25722, 3, 12179, 3772, 12, 13215, 13, 1982, 3045, 2409, 17913, 25722, 17, 2719, 20471, 1922, 3615, 18, 5656, 3615, 2430, 6624, 16, 4101, 8562, 3]}, "items": [{"id": "p_2004", "content": "Alfentanil [SEP] A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recov", "score": 1, "type": null, "tokenized_content": [2, 17913, 25722, 3, 43, 3662, 17, 8290, 9384, 16111, 1930, 14501, 10533, 1927, 20311, 18, 2176, 9300, 1925, 3120, 3833, 14501, 2495, 1930, 5867, 29326, 1020, 3]}]}
{"query": {"id": "q_2005", "content": "rigidity [SEP] racranial pressure (ICP) was measured during alfentanil-induced rigidity in rats. Ten rats had arterial, central venous (CVP), and subdu", "tokenized_content": [2, 20471, 3, 7195, 11548, 3772, 12, 13215, 13, 1982, 3045, 2409, 17913, 25722, 17, 2719, 20471, 1922, 3615, 18, 5656, 3615, 2430, 6624, 16, 4101, 8562, 12, 5519, 1034, 13, 3]}, "items": [{"id": "p_2005", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_2006", "content": "halothane [SEP] ial, central venous (CVP), and subdural cannulae inserted under halothane anesthesia. The animals were mechanically ventilated to achieve", "tokenized_content": [2, 23226, 1963, 2516, 3, 11640, 1024, 16, 4101, 8562, 12, 5519, 1034, 13, 16, 1930, 12923, 2741, 20865, 1021, 9103, 2441, 23226, 1963, 2516, 8871, 18, 1920, 3555, 1985, 17841, 3]}, "items": [{"id": "p_2006", "content": "Halothane [SEP] A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analg", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 3, 43, 19136, 10082, 3368, 7272, 16, 24778, 1981, 16, 21638, 16111, 1988, 4558, 4322, 4052, 4408, 1956, 5082, 2014, 2239, 7817, 2855, 18, 2151, 1029, 3]}]}
{"query": {"id": "q_2007", "content": "somatic rigidity [SEP] ence from halothane anesthesia. In the five rats that developed somatic rigidity, ICP and CVP increased significantly above baseline (delta ICP ", "tokenized_content": [2, 8548, 20471, 3, 3350, 1021, 2037, 23226, 1963, 2516, 8871, 18, 1922, 1920, 3628, 3615, 1988, 3530, 8548, 20471, 16, 13215, 1930, 5519, 1034, 2502, 2567, 3538, 3703, 12, 9649, 3]}, "items": [{"id": "p_2007", "content": "Muscle Rigidity [SEP] Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected m", "score": 1, "type": null, "tokenized_content": [2, 3760, 20471, 3, 4798, 28493, 7637, 3760, 8332, 2154, 1977, 3868, 43, 15570, 1927, 5342, 13086, 3902, 18, 2469, 1925, 4218, 55, 3]}]}
{"query": {"id": "q_2008", "content": "metocurine [SEP] variables returned to baseline when rigidity was abolished with metocurine. In five rats that did not become rigid, ICP and CVP did not ch", "tokenized_content": [2, 2130, 1994, 17687, 3, 3832, 10418, 1942, 3703, 2469, 20471, 1982, 10979, 1956, 2130, 1994, 17687, 18, 1922, 3628, 3615, 1988, 2811, 2084, 5433, 12383, 16, 13215, 1930, 5519, 1034, 3]}, "items": [{"id": "p_2008", "content": "metocurine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2130, 1994, 17687, 3, 3]}]}
{"query": {"id": "q_2009", "content": "cis-platin [SEP] se cardiac effects during induction chemotherapy treatment with cis-platin and 5-fluorouracil.", "tokenized_content": [2, 5848, 17, 13003, 3, 2058, 4435, 2564, 2409, 4408, 5318, 2311, 1956, 5848, 17, 13003, 1930, 25, 17, 21353, 18, 3]}, "items": [{"id": "p_2009", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_2010", "content": "5-fluorouracil [SEP] cts during induction chemotherapy treatment with cis-platin and 5-fluorouracil.", "tokenized_content": [2, 25, 17, 21353, 3, 15359, 2409, 4408, 5318, 2311, 1956, 5848, 17, 13003, 1930, 25, 17, 21353, 18, 3]}, "items": [{"id": "p_2010", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_2011", "content": "head and neck carcinoma [SEP] Survival for patients with advanced head and neck carcinoma and esophageal carcinoma is poor with radiotherapy and/or surge", "tokenized_content": [2, 4469, 1930, 7467, 5373, 3, 3298, 1958, 2132, 1956, 5570, 4469, 1930, 7467, 5373, 1930, 10744, 5373, 1977, 3930, 1956, 8822, 1930, 19, 2014, 8107, 3]}, "items": [{"id": "p_2011", "content": "Head and Neck Neoplasms [SEP] Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus.", "score": 1, "type": null, "tokenized_content": [2, 4469, 1930, 7467, 15347, 3, 3793, 2960, 3861, 2014, 2539, 11894, 2037, 1920, 9565, 7553, 1927, 1920, 3178, 31, 4726, 8568, 31, 18421, 6907, 14272, 31, 27443, 31, 1930, 6775, 16749, 18, 3]}]}
{"query": {"id": "q_2012", "content": "esophageal carcinoma [SEP] Survival for patients with advanced head and neck carcinoma and esophageal carcinoma is poor with radiotherapy and/or surgery. Obviously, there is a", "tokenized_content": [2, 10744, 5373, 3, 3298, 1958, 2132, 1956, 5570, 4469, 1930, 7467, 5373, 1930, 10744, 5373, 1977, 3930, 1956, 8822, 1930, 19, 2014, 3782, 18, 13291, 16, 2276, 1977, 43, 3]}, "items": [{"id": "p_2012", "content": "Esophageal Neoplasms [SEP] Tumors or cancer of the ESOPHAGUS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10744, 15347, 3, 3861, 2014, 2539, 1927, 1920, 16749, 18, 3]}]}
{"query": {"id": "q_2013", "content": "cis-platin [SEP] ere is a need for effective chemotherapy. In the present study, cis-platin (80-120 mg/m2BSA) and 5-FU (1000 mg/m2BSA daily as a continuous", "tokenized_content": [2, 5848, 17, 13003, 3, 22561, 1977, 43, 2942, 1958, 3655, 5318, 18, 1922, 1920, 2481, 2161, 16, 5848, 17, 13003, 12, 3729, 17, 6103, 2786, 19, 6056, 2083, 1019, 13, 3]}, "items": [{"id": "p_2013", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_2014", "content": "5-FU [SEP] therapy. In the present study, cis-platin (80-120 mg/m2BSA) and 5-FU (1000 mg/m2BSA daily as a continuous infusion during 5 days) we", "tokenized_content": [2, 25, 17, 7391, 3, 3181, 18, 1922, 1920, 2481, 2161, 16, 5848, 17, 13003, 12, 3729, 17, 6103, 2786, 19, 6056, 2083, 1019, 13, 1930, 25, 17, 7391, 12, 5672, 3]}, "items": [{"id": "p_2014", "content": "Fluorouracil [SEP] A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTH", "score": 1, "type": null, "tokenized_content": [2, 21353, 3, 43, 21611, 5729, 1988, 1977, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 18, 2176, 20766, 1956, 2678, 4271, 2007, 7472, 1920, 7330, 19743, 2010, 3182, 3]}]}
{"query": {"id": "q_2015", "content": "cardiovascular disease [SEP] dings were performed. In the pre-treatment evaluation, signs of cardiovascular disease were found in 33 patients (43%). During treatment, adverse card", "tokenized_content": [2, 5321, 2573, 3, 27147, 1036, 1985, 2593, 18, 1922, 1920, 2097, 17, 2311, 4391, 16, 6879, 1927, 5321, 2573, 1985, 2435, 1922, 3401, 2132, 12, 3941, 9, 13, 18, 2409, 3]}, "items": [{"id": "p_2015", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_2016", "content": "cardiotoxicity [SEP] as the same as for the entire group, 64 years. The incidence of cardiotoxicity was not higher in patients with signs of cardiovascular disease", "tokenized_content": [2, 30490, 3, 1966, 1920, 2841, 1966, 1958, 1920, 5346, 2210, 16, 4723, 2739, 18, 1920, 4332, 1927, 30490, 1982, 2084, 2580, 1922, 2132, 1956, 6879, 1927, 5321, 2573, 3]}, "items": [{"id": "p_2016", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_2017", "content": "chest pain [SEP] atment evaluation. The most common signs of cardiotoxicity were chest pain, ST-T wave changes and atrial fibrillation. This was followed b", "tokenized_content": [2, 8475, 3594, 3, 7513, 1939, 4391, 18, 1920, 2501, 3059, 6879, 1927, 30490, 1985, 8475, 3594, 16, 1955, 17, 62, 5913, 2840, 1930, 9224, 13671, 18, 2052, 1982, 3489, 44, 3]}, "items": [{"id": "p_2017", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_2018", "content": "atrial fibrillation [SEP]  signs of cardiotoxicity were chest pain, ST-T wave changes and atrial fibrillation. This was followed by ventricular fibrillation in one patient a", "tokenized_content": [2, 9224, 13671, 3, 6879, 1927, 30490, 1985, 8475, 3594, 16, 1955, 17, 62, 5913, 2840, 1930, 9224, 13671, 18, 2052, 1982, 3489, 2007, 6493, 13671, 1922, 2340, 2774, 43, 3]}, "items": [{"id": "p_2018", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_2019", "content": "ventricular fibrillation [SEP] ST-T wave changes and atrial fibrillation. This was followed by ventricular fibrillation in one patient and sudden death in another. It is concluded tha", "tokenized_content": [2, 6493, 13671, 3, 1955, 17, 62, 5913, 2840, 1930, 9224, 13671, 18, 2052, 1982, 3489, 2007, 6493, 13671, 1922, 2340, 2774, 1930, 12446, 3539, 1922, 3741, 18, 2176, 1977, 7903, 3]}, "items": [{"id": "p_2019", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_2020", "content": "sudden death [SEP] his was followed by ventricular fibrillation in one patient and sudden death in another. It is concluded that patients on 5-FU treatment sho", "tokenized_content": [2, 12446, 3539, 3, 4167, 1982, 3489, 2007, 6493, 13671, 1922, 2340, 2774, 1930, 12446, 3539, 1922, 3741, 18, 2176, 1977, 7903, 1988, 2132, 1990, 25, 17, 7391, 2311, 8406, 3]}, "items": [{"id": "p_2020", "content": "Death, Sudden [SEP] The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiov", "score": 1, "type": null, "tokenized_content": [2, 3539, 16, 12446, 3, 1920, 20135, 10975, 1927, 2136, 8970, 23792, 4088, 16, 16687, 2007, 1920, 11047, 3257, 1927, 2698, 6329, 16, 5481, 16, 1930, 21129, 1020, 3]}]}
{"query": {"id": "q_2021", "content": "tachyarrhythmia [SEP]  and that the treatment should be discontinued if chest pain or tachyarrhythmia is observed.", "tokenized_content": [2, 12762, 9771, 18858, 10245, 6026, 3, 1930, 1988, 1920, 2311, 3066, 1998, 16087, 2647, 8475, 3594, 2014, 12762, 9771, 18858, 10245, 6026, 1977, 2528, 18, 3]}, "items": [{"id": "p_2021", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_2022", "content": "Verapamil [SEP] Verapamil-induced carbamazepine neurotoxicity. A report of two cases.", "tokenized_content": [2, 23300, 3, 23300, 17, 2719, 30315, 18034, 18, 43, 3809, 1927, 2288, 2919, 18, 3]}, "items": [{"id": "p_2022", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_2023", "content": "carbamazepine [SEP] Verapamil-induced carbamazepine neurotoxicity. A report of two cases.", "tokenized_content": [2, 30315, 3, 23300, 17, 2719, 30315, 18034, 18, 43, 3809, 1927, 2288, 2919, 18, 3]}, "items": [{"id": "p_2023", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_2024", "content": "neurotoxicity [SEP] Verapamil-induced carbamazepine neurotoxicity. A report of two cases.", "tokenized_content": [2, 18034, 3, 23300, 17, 2719, 30315, 18034, 18, 43, 3809, 1927, 2288, 2919, 18, 3]}, "items": [{"id": "p_2024", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2025", "content": "carbamazepine [SEP] Two patients with signs of carbamazepine neurotoxicity after combined treatment with verapamil showed co", "tokenized_content": [2, 30315, 3, 2288, 2132, 1956, 6879, 1927, 30315, 18034, 2256, 4252, 2311, 1956, 23300, 2594, 2081, 3]}, "items": [{"id": "p_2025", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_2026", "content": "neurotoxicity [SEP] Two patients with signs of carbamazepine neurotoxicity after combined treatment with verapamil showed complete recover", "tokenized_content": [2, 18034, 3, 2288, 2132, 1956, 6879, 1927, 30315, 18034, 2256, 4252, 2311, 1956, 23300, 2594, 4080, 4309, 3]}, "items": [{"id": "p_2026", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2027", "content": "verapamil [SEP] ns of carbamazepine neurotoxicity after combined treatment with verapamil showed complete recovery after discontinuation of the calcium e", "tokenized_content": [2, 23300, 3, 4246, 1927, 30315, 18034, 2256, 4252, 2311, 1956, 23300, 2594, 4080, 5241, 2256, 14775, 1927, 1920, 5016, 47, 3]}, "items": [{"id": "p_2027", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_2028", "content": "calcium [SEP] verapamil showed complete recovery after discontinuation of the calcium entry blocker. Use of verapamil in combination with carbamazepi", "tokenized_content": [2, 5016, 3, 23300, 2594, 4080, 5241, 2256, 14775, 1927, 1920, 5016, 6904, 14580, 18, 2485, 1927, 23300, 1922, 3921, 1956, 17742, 18570, 1033, 3]}, "items": [{"id": "p_2028", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2029", "content": "auditory neurotoxicity [SEP] Serial studies of auditory neurotoxicity in patients receiving deferoxamine therapy.", "tokenized_content": [2, 8401, 18034, 3, 9285, 2351, 1927, 8401, 18034, 1922, 2132, 5962, 20519, 2325, 3812, 3181, 18, 3]}, "items": [{"id": "p_2029", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_2030", "content": "deferoxamine [SEP] Serial studies of auditory neurotoxicity in patients receiving deferoxamine therapy.", "tokenized_content": [2, 20519, 2325, 3812, 3, 9285, 2351, 1927, 8401, 18034, 1922, 2132, 5962, 20519, 2325, 3812, 3181, 18, 3]}, "items": [{"id": "p_2030", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_2031", "content": "auditory neurotoxicity [SEP] Visual and auditory neurotoxicity was previously documented in 42 of 89 patients with transfusion", "tokenized_content": [2, 8401, 18034, 3, 3737, 1930, 8401, 18034, 1982, 3024, 6974, 1922, 3858, 1927, 5792, 2132, 1956, 11508, 3]}, "items": [{"id": "p_2031", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_2032", "content": "anemia [SEP] usly documented in 42 of 89 patients with transfusion-dependent anemia who were receiving iron chelation therapy with daily subcutaneo", "tokenized_content": [2, 10679, 3, 2022, 1954, 6974, 1922, 3858, 1927, 5792, 2132, 1956, 11508, 17, 3100, 10679, 2746, 1985, 5962, 5680, 28526, 3181, 1956, 4692, 5736, 26455, 2912, 1037, 3]}, "items": [{"id": "p_2032", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_2033", "content": "iron [SEP] 9 patients with transfusion-dependent anemia who were receiving iron chelation therapy with daily subcutaneous deferoxamine. Twenty-", "tokenized_content": [2, 5680, 3, 29, 2132, 1956, 11508, 17, 3100, 10679, 2746, 1985, 5962, 5680, 28526, 3181, 1956, 4692, 8634, 20519, 2325, 3812, 18, 7639, 17, 3]}, "items": [{"id": "p_2033", "content": "Iron [SEP] A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBI", "score": 1, "type": null, "tokenized_content": [2, 5680, 3, 43, 16790, 6149, 1956, 11241, 17530, 2650, 16, 11241, 2529, 3179, 16, 1930, 11241, 3388, 4288, 18, 5140, 18, 2176, 1977, 1925, 4415, 18690, 1927, 3243, 6292, 1033, 3]}]}
{"query": {"id": "q_2034", "content": "deferoxamine [SEP] o were receiving iron chelation therapy with daily subcutaneous deferoxamine. Twenty-two patients in the affected group had abnormal audiogr", "tokenized_content": [2, 20519, 2325, 3812, 3, 57, 1985, 5962, 5680, 28526, 3181, 1956, 4692, 8634, 20519, 2325, 3812, 18, 7639, 17, 2288, 2132, 1922, 1920, 4218, 2210, 2430, 4552, 18609, 2299, 3]}, "items": [{"id": "p_2034", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_2035", "content": "abnormal audiograms with deficits mostly in the high frequency range of 4,000 to 8,000 Hz [SEP] ous deferoxamine. Twenty-two patients in the affected group had abnormal audiograms with deficits mostly in the high frequency range of 4,000 to 8,000 Hz and in the hearing threshold levels of 30 to 100 decibels. When", "tokenized_content": [2, 4552, 18609, 28218, 1956, 7961, 6969, 1922, 1920, 2149, 3528, 3109, 1927, 24, 16, 3240, 1942, 28, 16, 3240, 4865, 3, 17208, 1036, 20519, 2325, 3812, 18, 7639, 17, 2288, 3]}, "items": [{"id": "p_2035", "content": "Hearing Loss, High-Frequency [SEP] Hearing loss in frequencies above 1000 hertz.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 2149, 17, 3528, 3, 8512, 3257, 1922, 6458, 3538, 5672, 3656, 15982, 18, 3]}]}
{"query": {"id": "q_2036", "content": "permanent disability [SEP] ned abnormal and four patients required hearing aids because of permanent disability. Since 18 of the 22 patients were initially receiving deferoxam", "tokenized_content": [2, 11047, 8015, 3, 2069, 1007, 4552, 1930, 3006, 2132, 3414, 8512, 8494, 2882, 1927, 11047, 8015, 18, 3328, 2654, 1927, 1920, 2950, 2132, 1985, 6370, 5962, 20519, 2325, 1976, 3]}, "items": [{"id": "p_2036", "content": "Deafness [SEP] A general term for the complete loss of the ability to hear from both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25371, 3, 43, 3335, 2576, 1958, 1920, 4080, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_2037", "content": "auditory abnormality [SEP] s, usually 50 mg/kg per dose or less depending on the degree of auditory abnormality, and with the exception of two cases no further toxicity was de", "tokenized_content": [2, 8401, 14311, 3, 61, 16, 5394, 2761, 2786, 19, 3621, 2079, 3253, 2014, 2941, 6362, 1990, 1920, 4647, 1927, 8401, 14311, 16, 1930, 1956, 1920, 7541, 1927, 2288, 2919, 2239, 3]}, "items": [{"id": "p_2037", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_2038", "content": "toxicity [SEP] Visual and auditory neurotoxicity was previously documented in 42 of 89 patients with transfusion", "tokenized_content": [2, 5532, 3, 3737, 1930, 8401, 18034, 1982, 3024, 6974, 1922, 3858, 1927, 5792, 2132, 1956, 11508, 3]}, "items": [{"id": "p_2038", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2039", "content": "ototoxicity [SEP] use-and-effect relation between deferoxamine administration and ototoxicity. Based on these data, a plan of management was developed that a", "tokenized_content": [2, 7608, 11930, 3, 2485, 17, 1930, 17, 2495, 6147, 2192, 20519, 2325, 3812, 4183, 1930, 7608, 11930, 18, 2454, 1990, 2144, 2230, 16, 43, 4720, 1927, 4280, 1982, 3530, 1988, 3]}, "items": [{"id": "p_2039", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_2040", "content": "hearing loss [SEP] /kg per dose with careful monitoring. In those with symptoms of hearing loss, the drug should be stopped for four weeks, and when the audiog", "tokenized_content": [2, 8512, 3257, 3, 19, 3621, 2079, 3253, 1956, 8279, 5378, 18, 1922, 2690, 1956, 3601, 1927, 8512, 3257, 16, 1920, 2838, 3066, 1998, 12032, 1958, 3006, 3625, 16, 1930, 2469, 3]}, "items": [{"id": "p_2040", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_2041", "content": "auditory dysfunction [SEP] ng patients with normal serum ferritin values and in those with auditory dysfunction.", "tokenized_content": [2, 8401, 5273, 3, 4375, 2132, 1956, 2791, 3256, 15552, 2851, 1930, 1922, 2690, 1956, 8401, 5273, 18, 3]}, "items": [{"id": "p_2041", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_2042", "content": "Flurbiprofen [SEP] Flurbiprofen in the treatment of juvenile rheumatoid arthritis.", "tokenized_content": [2, 2848, 16007, 16979, 18514, 3, 2848, 16007, 16979, 18514, 1922, 1920, 2311, 1927, 13010, 13053, 8884, 18, 3]}, "items": [{"id": "p_2042", "content": "Flurbiprofen [SEP] An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in", "score": 1, "type": null, "tokenized_content": [2, 2848, 16007, 16979, 18514, 3, 1925, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 1927, 1920, 7971, 5135, 2304, 8643, 2687, 4696, 18, 2176, 2258, 2252, 2522, 1942, 4412, 3622, 14843, 1922, 3]}]}
{"query": {"id": "q_2043", "content": "juvenile rheumatoid arthritis [SEP] Flurbiprofen in the treatment of juvenile rheumatoid arthritis.", "tokenized_content": [2, 13010, 13053, 8884, 3, 2848, 16007, 16979, 18514, 1922, 1920, 2311, 1927, 13010, 13053, 8884, 18, 3]}, "items": [{"id": "p_2043", "content": "Arthritis, Juvenile [SEP] Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic ", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13010, 3, 8884, 1927, 3069, 16, 1956, 4727, 3119, 2641, 2739, 1927, 2632, 18, 1920, 4430, 13010, 13053, 8884, 12, 21886, 1019, 13, 1930, 13010, 13513, 3]}]}
{"query": {"id": "q_2044", "content": "juvenile rheumatoid arthritis [SEP] Thirty-four patients with juvenile rheumatoid arthritis, who were treated with flurbiprofen at a maximum dose of 4 mg/k", "tokenized_content": [2, 13010, 13053, 8884, 3, 9942, 17, 3006, 2132, 1956, 13010, 13053, 8884, 16, 2746, 1985, 2868, 1956, 2848, 16007, 16979, 18514, 2019, 43, 4419, 3253, 1927, 24, 2786, 19, 53, 3]}, "items": [{"id": "p_2044", "content": "Arthritis, Juvenile [SEP] Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic ", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13010, 3, 8884, 1927, 3069, 16, 1956, 4727, 3119, 2641, 2739, 1927, 2632, 18, 1920, 4430, 13010, 13053, 8884, 12, 21886, 1019, 13, 1930, 13010, 13513, 3]}]}
{"query": {"id": "q_2045", "content": "flurbiprofen [SEP] ients with juvenile rheumatoid arthritis, who were treated with flurbiprofen at a maximum dose of 4 mg/kg/day, had statistically significant", "tokenized_content": [2, 2848, 16007, 16979, 18514, 3, 10116, 4905, 1036, 1956, 13010, 13053, 8884, 16, 2746, 1985, 2868, 1956, 2848, 16007, 16979, 18514, 2019, 43, 4419, 3253, 1927, 24, 2786, 19, 3621, 3]}, "items": [{"id": "p_2045", "content": "Flurbiprofen [SEP] An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in", "score": 1, "type": null, "tokenized_content": [2, 2848, 16007, 16979, 18514, 3, 1925, 2246, 17, 3769, 14501, 1930, 2246, 18425, 3023, 1927, 1920, 7971, 5135, 2304, 8643, 2687, 4696, 18, 2176, 2258, 2252, 2522, 1942, 4412, 3622, 14843, 1922, 3]}]}
{"query": {"id": "q_2046", "content": "arthritis [SEP] Thirty-four patients with juvenile rheumatoid arthritis, who were treated with flurbiprofen at a maximum dose of 4 mg/k", "tokenized_content": [2, 8884, 3, 9942, 17, 3006, 2132, 1956, 13010, 13053, 8884, 16, 2746, 1985, 2868, 1956, 2848, 16007, 16979, 18514, 2019, 43, 4419, 3253, 1927, 24, 2786, 19, 53, 3]}, "items": [{"id": "p_2046", "content": "Arthritis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8884, 3, 3]}]}
{"query": {"id": "q_2047", "content": "swelling [SEP] ments were seen in the number of tender joints, the severity of swelling and tenderness, the time of walk 50 feet, the duration of morni", "tokenized_content": [2, 11438, 3, 11567, 1036, 1985, 3945, 1922, 1920, 2529, 1927, 19961, 12648, 16, 1920, 5155, 1927, 11438, 1930, 25900, 16, 1920, 2367, 1927, 6846, 2761, 18071, 16, 1920, 4392, 1927, 3]}, "items": [{"id": "p_2047", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_2048", "content": "gastrointestinal (GI) bleeding [SEP] lood (25% of patients); however, there was no other evidence of gastrointestinal (GI) bleeding in these patients. One patient was prematurely discontinued fro", "tokenized_content": [2, 8375, 12, 7217, 13, 7633, 3, 3004, 1986, 12, 2637, 9, 1927, 2132, 13, 31, 2406, 16, 2276, 1982, 2239, 2303, 3095, 1927, 8375, 12, 7217, 13, 7633, 1922, 2144, 3]}, "items": [{"id": "p_2048", "content": "Gastrointestinal Hemorrhage [SEP] Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 10489, 3, 7633, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_2049", "content": "headache [SEP]  patient was prematurely discontinued from the study for severe headache and abdominal pain. Most side effects were mild and related to ", "tokenized_content": [2, 12187, 3, 2774, 1982, 28283, 16087, 2037, 1920, 2161, 1958, 4010, 12187, 1930, 6900, 3594, 18, 2501, 4159, 2564, 1985, 5809, 1930, 2712, 1942, 3]}, "items": [{"id": "p_2049", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_2050", "content": "abdominal pain [SEP] prematurely discontinued from the study for severe headache and abdominal pain. Most side effects were mild and related to the GI tract.", "tokenized_content": [2, 6900, 3594, 3, 28283, 16087, 2037, 1920, 2161, 1958, 4010, 12187, 1930, 6900, 3594, 18, 2501, 4159, 2564, 1985, 5809, 1930, 2712, 1942, 1920, 7217, 6482, 18, 3]}, "items": [{"id": "p_2050", "content": "Abdominal Pain [SEP] Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue inju", "score": 1, "type": null, "tokenized_content": [2, 6900, 3594, 3, 15826, 1927, 15335, 16, 8740, 16, 2014, 6024, 1012, 1922, 1920, 6900, 3031, 31, 4933, 2458, 1956, 3183, 4414, 16, 2960, 2831, 1032, 3]}]}
{"query": {"id": "q_2051", "content": "neurotoxic [SEP] The correlation between neurotoxic esterase inhibition and mipafox-induced neuropathic damage in r", "tokenized_content": [2, 20919, 3, 1920, 3670, 2192, 20919, 26389, 3523, 1930, 15070, 2624, 2325, 17, 2719, 16591, 4293, 1922, 60, 3]}, "items": [{"id": "p_2051", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2052", "content": "mipafox [SEP] The correlation between neurotoxic esterase inhibition and mipafox-induced neuropathic damage in rats.", "tokenized_content": [2, 15070, 2624, 2325, 3, 1920, 3670, 2192, 20919, 26389, 3523, 1930, 15070, 2624, 2325, 17, 2719, 16591, 4293, 1922, 3615, 18, 3]}, "items": [{"id": "p_2052", "content": "mipafox [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15070, 2624, 2325, 3, 3]}]}
{"query": {"id": "q_2053", "content": "neuropathic damage [SEP] tion between neurotoxic esterase inhibition and mipafox-induced neuropathic damage in rats.", "tokenized_content": [2, 16591, 4293, 3, 8685, 1916, 2192, 20919, 26389, 3523, 1930, 15070, 2624, 2325, 17, 2719, 16591, 4293, 1922, 3615, 18, 3]}, "items": [{"id": "p_2053", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2054", "content": "neuropathic damage [SEP] The correlation between neuropathic damage and inhibition of neurotoxic esterase or neuropathy target enzy", "tokenized_content": [2, 16591, 4293, 3, 1920, 3670, 2192, 16591, 4293, 1930, 3523, 1927, 20919, 26389, 2014, 13177, 2758, 27862, 1012, 3]}, "items": [{"id": "p_2054", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2055", "content": "neurotoxic [SEP] The correlation between neuropathic damage and inhibition of neurotoxic esterase or neuropathy target enzyme (NTE) was examined in rats", "tokenized_content": [2, 20919, 3, 1920, 3670, 2192, 16591, 4293, 1930, 3523, 1927, 20919, 26389, 2014, 13177, 2758, 4113, 12, 5891, 1021, 13, 1982, 3572, 1922, 3615, 3]}, "items": [{"id": "p_2055", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2056", "content": "neuropathy [SEP] een neuropathic damage and inhibition of neurotoxic esterase or neuropathy target enzyme (NTE) was examined in rats acutely exposed to Mip", "tokenized_content": [2, 13177, 3, 11150, 1022, 16591, 4293, 1930, 3523, 1927, 20919, 26389, 2014, 13177, 2758, 4113, 12, 5891, 1021, 13, 1982, 3572, 1922, 3615, 18141, 4616, 1942, 15070, 3]}, "items": [{"id": "p_2056", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2057", "content": "Mipafox [SEP] thy target enzyme (NTE) was examined in rats acutely exposed to Mipafox (N, N'-diisopropylphosphorodiamidofluoridate), a neurotoxic org", "tokenized_content": [2, 15070, 2624, 2325, 3, 24035, 2758, 4113, 12, 5891, 1021, 13, 1982, 3572, 1922, 3615, 18141, 4616, 1942, 15070, 2624, 2325, 12, 56, 16, 56, 11, 17, 26028, 2204, 20194, 3]}, "items": [{"id": "p_2057", "content": "mipafox [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15070, 2624, 2325, 3, 3]}]}
{"query": {"id": "q_2058", "content": "N, N'-diisopropylphosphorodiamidofluoridate [SEP] t enzyme (NTE) was examined in rats acutely exposed to Mipafox (N, N'-diisopropylphosphorodiamidofluoridate), a neurotoxic organophosphate. Brain and spinal cord NTE activ", "tokenized_content": [2, 56, 16, 56, 11, 17, 26028, 2204, 20194, 2199, 10614, 13968, 16408, 4199, 11525, 21550, 3, 62, 4113, 12, 5891, 1021, 13, 1982, 3572, 1922, 3615, 18141, 4616, 1942, 15070, 3]}, "items": [{"id": "p_2058", "content": "mipafox [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15070, 2624, 2325, 3, 3]}]}
{"query": {"id": "q_2059", "content": "organophosphate [SEP] fox (N, N'-diisopropylphosphorodiamidofluoridate), a neurotoxic organophosphate. Brain and spinal cord NTE activities were measured in Long-Eva", "tokenized_content": [2, 3090, 15707, 3, 6280, 12, 56, 16, 56, 11, 17, 26028, 2204, 20194, 2199, 10614, 13968, 16408, 4199, 11525, 21550, 13, 16, 43, 20919, 3090, 15707, 18, 3068, 1930, 6071, 3]}, "items": [{"id": "p_2059", "content": "Organophosphates [SEP] Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or ", "score": 1, "type": null, "tokenized_content": [2, 3090, 15707, 1036, 3, 5056, 17, 3165, 3421, 1935, 2687, 8383, 18, 3063, 2441, 2052, 26300, 2032, 4300, 1988, 2162, 5056, 9030, 4124, 1942, 2340, 2014, 3]}]}
{"query": {"id": "q_2060", "content": "cord damage [SEP]  These data were correlated with histologically scored cervical cord damage in a separate group of similarly dosed rats sampled 14-21 days ", "tokenized_content": [2, 6670, 4293, 3, 2144, 2230, 1985, 4374, 1956, 15055, 9032, 6775, 6670, 4293, 1922, 43, 5850, 2210, 1927, 4852, 25922, 3615, 8783, 2607, 17, 2900, 3000, 3]}, "items": [{"id": "p_2060", "content": "Spinal Cord Diseases [SEP] Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimening", "score": 1, "type": null, "tokenized_content": [2, 6071, 6670, 3902, 3, 11896, 2961, 2154, 5961, 6071, 6670, 4293, 2014, 5273, 16, 2710, 4414, 5884, 1920, 10286, 1918, 1930, 2953, 19047, 1941, 3]}]}
{"query": {"id": "q_2061", "content": "Cerebral infarction [SEP] Cerebral infarction with a single oral dose of phenylpropanolamine.", "tokenized_content": [2, 6329, 8358, 3, 6329, 8358, 1956, 43, 2957, 4726, 3253, 1927, 7971, 20194, 4296, 3812, 18, 3]}, "items": [{"id": "p_2061", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_2062", "content": "phenylpropanolamine [SEP] Cerebral infarction with a single oral dose of phenylpropanolamine.", "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 6329, 8358, 1956, 43, 2957, 4726, 3253, 1927, 7971, 20194, 4296, 3812, 18, 3]}, "items": [{"id": "p_2062", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_2063", "content": "Phenylpropanolamine [SEP] Phenylpropanolamine (PPA), a synthetic sympathomimetic that is structurally similar", "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 7971, 20194, 4296, 3812, 12, 27301, 13, 16, 43, 6830, 26638, 1947, 21870, 1988, 1977, 12171, 2551, 3]}, "items": [{"id": "p_2063", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_2064", "content": "PPA [SEP] Phenylpropanolamine (PPA), a synthetic sympathomimetic that is structurally similar to a", "tokenized_content": [2, 27301, 3, 7971, 20194, 4296, 3812, 12, 27301, 13, 16, 43, 6830, 26638, 1947, 21870, 1988, 1977, 12171, 2551, 1942, 43, 3]}, "items": [{"id": "p_2064", "content": "Phenylpropanolamine [SEP] A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic ", "score": 1, "type": null, "tokenized_content": [2, 7971, 20194, 4296, 3812, 3, 43, 26638, 1947, 21870, 1988, 8016, 4994, 2007, 7538, 4012, 1927, 16436, 2308, 2222, 2258, 3083, 7829, 2455, 2019, 2673, 13672, 3]}]}
{"query": {"id": "q_2065", "content": "amphetamine [SEP] A), a synthetic sympathomimetic that is structurally similar to amphetamine, is available over the counter in anorectics, nasal congestants", "tokenized_content": [2, 19057, 3, 43, 13, 16, 43, 6830, 26638, 1947, 21870, 1988, 1977, 12171, 2551, 1942, 19057, 16, 1977, 3322, 2338, 1920, 5836, 1922, 28976, 8955, 3048, 16, 9305, 15188, 3285, 3]}, "items": [{"id": "p_2065", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_2066", "content": "seizures [SEP] arations. Its prolonged use or overuse has been associated with seizures, intracerebral hemorrhage, neuropsychiatric symptoms, and nonhe", "tokenized_content": [2, 10060, 3, 20289, 3104, 18, 2496, 7171, 2485, 2014, 2338, 2517, 2258, 2252, 2458, 1956, 10060, 16, 24152, 10489, 16, 19305, 3601, 16, 1930, 16925, 1021, 3]}, "items": [{"id": "p_2066", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2067", "content": "intracerebral hemorrhage [SEP] Its prolonged use or overuse has been associated with seizures, intracerebral hemorrhage, neuropsychiatric symptoms, and nonhemorrhagic cerebral infarct", "tokenized_content": [2, 24152, 10489, 3, 2496, 7171, 2485, 2014, 2338, 2517, 2258, 2252, 2458, 1956, 10060, 16, 24152, 10489, 16, 19305, 3601, 16, 1930, 16925, 1987, 6990, 12550, 6329, 13389, 3]}, "items": [{"id": "p_2067", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2068", "content": "neuropsychiatric symptoms [SEP] se has been associated with seizures, intracerebral hemorrhage, neuropsychiatric symptoms, and nonhemorrhagic cerebral infarction. We report the case of ", "tokenized_content": [2, 19305, 3601, 3, 2058, 2258, 2252, 2458, 1956, 10060, 16, 24152, 10489, 16, 19305, 3601, 16, 1930, 16925, 1987, 6990, 12550, 6329, 8358, 18, 2038, 3809, 1920, 3087, 1927, 3]}, "items": [{"id": "p_2068", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_2069", "content": "cerebral infarction [SEP] ebral hemorrhage, neuropsychiatric symptoms, and nonhemorrhagic cerebral infarction. We report the case of a young woman who suffered a cerebral in", "tokenized_content": [2, 6329, 8358, 3, 6560, 7317, 10489, 16, 19305, 3601, 16, 1930, 16925, 1987, 6990, 12550, 6329, 8358, 18, 2038, 3809, 1920, 3087, 1927, 43, 4201, 10440, 2746, 13949, 43, 6329, 3]}, "items": [{"id": "p_2069", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_2070", "content": "psoriasis [SEP] Treatment of psoriasis with azathioprine.", "tokenized_content": [2, 14109, 3, 2311, 1927, 14109, 1956, 30499, 5773, 18, 3]}, "items": [{"id": "p_2070", "content": "Psoriasis [SEP] A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches.", "score": 1, "type": null, "tokenized_content": [2, 14109, 3, 43, 3059, 9517, 3180, 16, 3724, 16, 3769, 4407, 2573, 4378, 2007, 19506, 19216, 2080, 16, 7143, 16, 12351, 12667, 18, 3]}]}
{"query": {"id": "q_2071", "content": "azathioprine [SEP] Treatment of psoriasis with azathioprine.", "tokenized_content": [2, 30499, 5773, 3, 2311, 1927, 14109, 1956, 30499, 5773, 18, 3]}, "items": [{"id": "p_2071", "content": "Azathioprine [SEP] An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 30499, 5773, 3, 1925, 12910, 5899, 2251, 1922, 3921, 1956, 17135, 1930, 8275, 11600, 1037, 15520, 1922, 1920, 2311, 1927, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_2072", "content": "Azathioprine [SEP] Azathioprine treatment benefited 19 (66%) out of 29 patients suffering from ", "tokenized_content": [2, 30499, 5773, 3, 30499, 5773, 2311, 29114, 2282, 12, 4970, 9, 13, 2397, 1927, 3230, 2132, 11364, 2037, 3]}, "items": [{"id": "p_2072", "content": "Azathioprine [SEP] An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 30499, 5773, 3, 1925, 12910, 5899, 2251, 1922, 3921, 1956, 17135, 1930, 8275, 11600, 1037, 15520, 1922, 1920, 2311, 1927, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_2073", "content": "psoriasis [SEP] ent benefited 19 (66%) out of 29 patients suffering from severe psoriasis. Haematological complications were not troublesome and results ", "tokenized_content": [2, 14109, 3, 8496, 29114, 2282, 12, 4970, 9, 13, 2397, 1927, 3230, 2132, 11364, 2037, 4010, 14109, 18, 28691, 5021, 1985, 2084, 20925, 15763, 2225, 1930, 2274, 3]}, "items": [{"id": "p_2073", "content": "Psoriasis [SEP] A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches.", "score": 1, "type": null, "tokenized_content": [2, 14109, 3, 43, 3059, 9517, 3180, 16, 3724, 16, 3769, 4407, 2573, 4378, 2007, 19506, 19216, 2080, 16, 7143, 16, 12351, 12667, 18, 3]}]}
{"query": {"id": "q_2074", "content": "cholestasis [SEP] ts of biochemical liver function tests remained normal. Minimal cholestasis was seen in two cases and portal fibrosis of a reversible degre", "tokenized_content": [2, 30086, 3, 4894, 1927, 6503, 3568, 2347, 4026, 5410, 2791, 18, 6343, 30086, 1982, 3945, 1922, 2288, 2919, 1930, 10669, 6769, 1927, 43, 10743, 3744, 1936, 3]}, "items": [{"id": "p_2074", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_2075", "content": "fibrosis [SEP] ed normal. Minimal cholestasis was seen in two cases and portal fibrosis of a reversible degree in eight. Liver biopsies should be under", "tokenized_content": [2, 6769, 3, 3347, 2791, 18, 6343, 30086, 1982, 3945, 1922, 2288, 2919, 1930, 10669, 6769, 1927, 43, 10743, 4647, 1922, 5066, 18, 3568, 9782, 3066, 1998, 2441, 3]}, "items": [{"id": "p_2075", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_2076", "content": "azathioprine [SEP] ht. Liver biopsies should be undertaken at regular intervals if azathioprine therapy is continued so that structural liver damage may be det", "tokenized_content": [2, 30499, 5773, 3, 5334, 18, 3568, 9782, 3066, 1998, 10466, 2019, 6314, 6087, 2647, 30499, 5773, 3181, 1977, 7583, 2577, 1988, 4346, 3568, 4293, 2278, 1998, 2212, 3]}, "items": [{"id": "p_2076", "content": "Azathioprine [SEP] An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 30499, 5773, 3, 1925, 12910, 5899, 2251, 1922, 3921, 1956, 17135, 1930, 8275, 11600, 1037, 15520, 1922, 1920, 2311, 1927, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_2077", "content": "liver damage [SEP] tervals if azathioprine therapy is continued so that structural liver damage may be detected at an early and reversible stage.", "tokenized_content": [2, 3568, 4293, 3, 6005, 4701, 1036, 2647, 30499, 5773, 3181, 1977, 7583, 2577, 1988, 4346, 3568, 4293, 2278, 1998, 3330, 2019, 1925, 3120, 1930, 10743, 3587, 18, 3]}, "items": [{"id": "p_2077", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2078", "content": "lithium [SEP] Maternal lithium and neonatal Ebstein's anomaly: evaluation with cross-sectional", "tokenized_content": [2, 14330, 3, 5509, 14330, 1930, 7985, 19183, 8037, 11, 61, 20950, 30, 4391, 1956, 3567, 17, 7360, 3]}, "items": [{"id": "p_2078", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2079", "content": "Ebstein's anomaly [SEP] Maternal lithium and neonatal Ebstein's anomaly: evaluation with cross-sectional echocardiography.", "tokenized_content": [2, 19183, 8037, 11, 61, 20950, 3, 5509, 14330, 1930, 7985, 19183, 8037, 11, 61, 20950, 30, 4391, 1956, 3567, 17, 7360, 12814, 18, 3]}, "items": [{"id": "p_2079", "content": "Ebstein Anomaly [SEP] A congenital heart defect characterized by downward or apical displacement of the TRICUSPID VALVE, usually with the septal and p", "score": 1, "type": null, "tokenized_content": [2, 19183, 8037, 20950, 3, 43, 9901, 4003, 7374, 4378, 2007, 20130, 2014, 8913, 9514, 1927, 1920, 25487, 9509, 16, 5394, 1956, 1920, 16458, 1930, 58, 3]}]}
{"query": {"id": "q_2080", "content": "lithium [SEP] graphy was used to evaluate two neonates whose mothers ingested lithium during pregnancy. In one infant, Ebstein's anomaly of the tricu", "tokenized_content": [2, 14330, 3, 4982, 1012, 1982, 2251, 1942, 4323, 2288, 13250, 6098, 7026, 20833, 14330, 2409, 5284, 18, 1922, 2340, 8125, 16, 19183, 8037, 11, 61, 20950, 1927, 1920, 12258, 1032, 3]}, "items": [{"id": "p_2080", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2081", "content": "Ebstein's anomaly [SEP] whose mothers ingested lithium during pregnancy. In one infant, Ebstein's anomaly of the tricuspid valve was identified. In the other infant cros", "tokenized_content": [2, 19183, 8037, 11, 61, 20950, 3, 6098, 7026, 20833, 14330, 2409, 5284, 18, 1922, 2340, 8125, 16, 19183, 8037, 11, 61, 20950, 1927, 1920, 25487, 9509, 1982, 2899, 18, 1922, 3]}, "items": [{"id": "p_2081", "content": "Ebstein Anomaly [SEP] A congenital heart defect characterized by downward or apical displacement of the TRICUSPID VALVE, usually with the septal and p", "score": 1, "type": null, "tokenized_content": [2, 19183, 8037, 20950, 3, 43, 9901, 4003, 7374, 4378, 2007, 20130, 2014, 8913, 9514, 1927, 1920, 25487, 9509, 16, 5394, 1956, 1920, 16458, 1930, 58, 3]}]}
{"query": {"id": "q_2082", "content": "cardiac malformations [SEP] vasive assessment of the presence or absence of lithium-induced cardiac malformations.", "tokenized_content": [2, 4435, 17360, 3, 6350, 2320, 4076, 1927, 1920, 2990, 2014, 3905, 1927, 14330, 17, 2719, 4435, 17360, 18, 3]}, "items": [{"id": "p_2082", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_2083", "content": "myocardial infarction [SEP] Effects of training on the extent of experimental myocardial infarction in aging rats.", "tokenized_content": [2, 6497, 8358, 3, 2564, 1927, 4096, 1990, 1920, 5064, 1927, 3599, 6497, 8358, 1922, 6619, 3615, 18, 3]}, "items": [{"id": "p_2083", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_2084", "content": "isoproterenol [SEP] The effects of exercise on the severity of isoproterenol-induced myocardial infarction were studied in female albino rat", "tokenized_content": [2, 23743, 3, 1920, 2564, 1927, 4975, 1990, 1920, 5155, 1927, 23743, 17, 2719, 6497, 8358, 1985, 3942, 1922, 4232, 28734, 3067, 3]}, "items": [{"id": "p_2084", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_2085", "content": "myocardial infarction [SEP] he effects of exercise on the severity of isoproterenol-induced myocardial infarction were studied in female albino rats of 20,40,60 and 80 weeks of ", "tokenized_content": [2, 6497, 8358, 3, 2234, 2564, 1927, 4975, 1990, 1920, 5155, 1927, 23743, 17, 2719, 6497, 8358, 1985, 3942, 1922, 4232, 28734, 3615, 1927, 2036, 16, 3040, 16, 3276, 1930, 3729, 3]}, "items": [{"id": "p_2085", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_2086", "content": "infarcts [SEP] pecific duration and for a particular period. The occurrence of infarcts were confirmed by histological methods. Elevations in the serum", "tokenized_content": [2, 28701, 3, 13494, 2077, 4392, 1930, 1958, 43, 3278, 3047, 18, 1920, 6564, 1927, 28701, 1985, 3982, 2007, 6791, 2860, 18, 17554, 1922, 1920, 3256, 3]}, "items": [{"id": "p_2086", "content": "Infarction [SEP] Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most", "score": 1, "type": null, "tokenized_content": [2, 8358, 3, 3337, 1927, 1925, 13389, 16, 2154, 1977, 7476, 1922, 2960, 2810, 1942, 3076, 7716, 3864, 2037, 10849, 1927, 2877, 9255, 16, 2501, 3]}]}
{"query": {"id": "q_2087", "content": "isoproterenols [SEP] evations in the serum GOT and GPT were maximum in the sedentary-isoproterenols and minimum in the exercise-controls. These changes in the seru", "tokenized_content": [2, 23743, 1036, 3, 2180, 2082, 1922, 1920, 3256, 14643, 1930, 4882, 1031, 1985, 4419, 1922, 1920, 13795, 17, 23743, 1036, 1930, 6081, 1922, 1920, 4975, 17, 3562, 18, 2144, 2840, 3]}, "items": [{"id": "p_2087", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_2088", "content": "polyethylene glycol 400 [SEP] Effect of polyethylene glycol 400 on adriamycin toxicity in mice.", "tokenized_content": [2, 15911, 14193, 5805, 3, 2495, 1927, 15911, 14193, 5805, 1990, 25622, 7898, 5532, 1922, 2518, 18, 3]}, "items": [{"id": "p_2088", "content": "Polyethylene Glycols [SEP] Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular", "score": 1, "type": null, "tokenized_content": [2, 15911, 14193, 1036, 3, 11039, 1927, 13183, 7491, 1930, 3224, 16, 1930, 2310, 14121, 1036, 18, 2611, 5304, 1922, 9592, 2037, 5875, 1942, 5358, 6362, 1990, 1920, 3272, 3]}]}
{"query": {"id": "q_2089", "content": "adriamycin [SEP] Effect of polyethylene glycol 400 on adriamycin toxicity in mice.", "tokenized_content": [2, 25622, 7898, 3, 2495, 1927, 15911, 14193, 5805, 1990, 25622, 7898, 5532, 1922, 2518, 18, 3]}, "items": [{"id": "p_2089", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2090", "content": "toxicity [SEP] Effect of polyethylene glycol 400 on adriamycin toxicity in mice.", "tokenized_content": [2, 5532, 3, 2495, 1927, 15911, 14193, 5805, 1990, 25622, 7898, 5532, 1922, 2518, 18, 3]}, "items": [{"id": "p_2090", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2091", "content": "polyethylene glycol 400 [SEP] The effect of a widely used organic solvent, polyethylene glycol 400 (PEG 400), on the toxic action of an acute or chronic treatment", "tokenized_content": [2, 15911, 14193, 5805, 3, 1920, 2495, 1927, 43, 5673, 2251, 6805, 7596, 16, 15911, 14193, 5805, 12, 7404, 5805, 13, 16, 1990, 1920, 6161, 4615, 1927, 1925, 3939, 2014, 3724, 3]}, "items": [{"id": "p_2091", "content": "Polyethylene Glycols [SEP] Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular", "score": 1, "type": null, "tokenized_content": [2, 15911, 14193, 1036, 3, 11039, 1927, 13183, 7491, 1930, 3224, 16, 1930, 2310, 14121, 1036, 18, 2611, 5304, 1922, 9592, 2037, 5875, 1942, 5358, 6362, 1990, 1920, 3272, 3]}]}
{"query": {"id": "q_2092", "content": "PEG 400 [SEP] fect of a widely used organic solvent, polyethylene glycol 400 (PEG 400), on the toxic action of an acute or chronic treatment with adr", "tokenized_content": [2, 7404, 5805, 3, 16688, 1031, 1927, 43, 5673, 2251, 6805, 7596, 16, 15911, 14193, 5805, 12, 7404, 5805, 13, 16, 1990, 1920, 6161, 4615, 1927, 1925, 3939, 2014, 3724, 2311, 3]}, "items": [{"id": "p_2092", "content": "Polyethylene Glycols [SEP] Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular", "score": 1, "type": null, "tokenized_content": [2, 15911, 14193, 1036, 3, 11039, 1927, 13183, 7491, 1930, 3224, 16, 1930, 2310, 14121, 1036, 18, 2611, 5304, 1922, 9592, 2037, 5875, 1942, 5358, 6362, 1990, 1920, 3272, 3]}]}
{"query": {"id": "q_2093", "content": "adriamycin [SEP] 400), on the toxic action of an acute or chronic treatment with adriamycin (ADR) was evaluated in mice. PEG 400 impressively decreased bot", "tokenized_content": [2, 25622, 7898, 3, 5805, 13, 16, 1990, 1920, 6161, 4615, 1927, 1925, 3939, 2014, 3724, 2311, 1956, 25622, 7898, 12, 17645, 13, 1982, 3747, 1922, 2518, 18, 7404, 5805, 25735, 3]}, "items": [{"id": "p_2093", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2094", "content": "ADR [SEP]  toxic action of an acute or chronic treatment with adriamycin (ADR) was evaluated in mice. PEG 400 impressively decreased both acu", "tokenized_content": [2, 17645, 3, 6161, 4615, 1927, 1925, 3939, 2014, 3724, 2311, 1956, 25622, 7898, 12, 17645, 13, 1982, 3747, 1922, 2518, 18, 7404, 5805, 25735, 1954, 3261, 2321, 2000, 1032, 3]}, "items": [{"id": "p_2094", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2095", "content": "cardiac morphological alterations [SEP] ic analysis showed a significant protection against ADR-induced cardiac morphological alterations. Such treatment did not diminish the ADR antitumor activity in ", "tokenized_content": [2, 4435, 7060, 5996, 3, 3996, 2333, 2594, 43, 2228, 6202, 3316, 17645, 17, 2719, 4435, 7060, 5996, 18, 2427, 2311, 2811, 2084, 16072, 1920, 17645, 11775, 2455, 1922, 3]}, "items": [{"id": "p_2095", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_2096", "content": "L1210 leukemia [SEP] . Such treatment did not diminish the ADR antitumor activity in L1210 leukemia and in Ehrlich ascites tumor.", "tokenized_content": [2, 7554, 4716, 1008, 8111, 3, 18, 2427, 2311, 2811, 2084, 16072, 1920, 17645, 11775, 2455, 1922, 7554, 4716, 1008, 8111, 1930, 1922, 17814, 24250, 17622, 2798, 18, 3]}, "items": [{"id": "p_2096", "content": "Leukemia L1210 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8111, 7554, 4716, 1008, 3, 3]}]}
{"query": {"id": "q_2097", "content": "Ehrlich ascites tumor [SEP] ot diminish the ADR antitumor activity in L1210 leukemia and in Ehrlich ascites tumor.", "tokenized_content": [2, 17814, 24250, 17622, 2798, 3, 7608, 16072, 1920, 17645, 11775, 2455, 1922, 7554, 4716, 1008, 8111, 1930, 1922, 17814, 24250, 17622, 2798, 18, 3]}, "items": [{"id": "p_2097", "content": "Carcinoma, Ehrlich Tumor [SEP] A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. ", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 17814, 24250, 2798, 3, 43, 5192, 2115, 16, 7865, 7512, 6558, 2798, 2154, 6209, 10398, 1966, 43, 6242, 3739, 5373, 1922, 43, 3321, 18, 3]}]}
{"query": {"id": "q_2098", "content": "BCNU [SEP] Intra-arterial BCNU chemotherapy for treatment of malignant gliomas of the central ", "tokenized_content": [2, 6452, 1022, 1032, 3, 5153, 17, 6624, 6452, 1022, 1032, 5318, 1958, 2311, 1927, 6558, 17083, 1927, 1920, 4101, 3]}, "items": [{"id": "p_2098", "content": "Carmustine [SEP] A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other ma", "score": 1, "type": null, "tokenized_content": [2, 2279, 23084, 4425, 3, 43, 2024, 17, 4048, 3193, 12720, 28912, 29128, 9969, 5899, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 3068, 3861, 1930, 3425, 2303, 2488, 3]}]}
{"query": {"id": "q_2099", "content": "malignant gliomas [SEP] Intra-arterial BCNU chemotherapy for treatment of malignant gliomas of the central nervous system.", "tokenized_content": [2, 6558, 17083, 3, 5153, 17, 6624, 6452, 1022, 1032, 5318, 1958, 2311, 1927, 6558, 17083, 1927, 1920, 4101, 7580, 2433, 18, 3]}, "items": [{"id": "p_2099", "content": "Glioma [SEP] Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymo", "score": 1, "type": null, "tokenized_content": [2, 10683, 3, 8867, 1930, 6558, 4101, 7580, 2433, 15347, 3595, 2037, 10786, 2094, 12, 51, 18, 47, 18, 16, 8948, 16, 19279, 16, 1930, 27222, 1037, 3]}]}
{"query": {"id": "q_2100", "content": "BCNU [SEP] Because of the rapid systemic clearance of BCNU (1,3-bis-(2-chloroethyl)-1-nitrosourea), intra-arterial adminis", "tokenized_content": [2, 6452, 1022, 1032, 3, 2882, 1927, 1920, 4052, 5510, 7802, 1927, 6452, 1022, 1032, 12, 21, 16, 23, 17, 7266, 17, 12, 22, 17, 10107, 5188, 13, 17, 21, 17, 3]}, "items": [{"id": "p_2100", "content": "Carmustine [SEP] A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other ma", "score": 1, "type": null, "tokenized_content": [2, 2279, 23084, 4425, 3, 43, 2024, 17, 4048, 3193, 12720, 28912, 29128, 9969, 5899, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 3068, 3861, 1930, 3425, 2303, 2488, 3]}]}
{"query": {"id": "q_2101", "content": "1,3-bis-(2-chloroethyl)-1-nitrosourea [SEP] Because of the rapid systemic clearance of BCNU (1,3-bis-(2-chloroethyl)-1-nitrosourea), intra-arterial administration should provide a substantial ad", "tokenized_content": [2, 21, 16, 23, 17, 7266, 17, 12, 22, 17, 10107, 5188, 13, 17, 21, 17, 16665, 2257, 5376, 3, 2882, 1927, 1920, 4052, 5510, 7802, 1927, 6452, 1022, 1032, 12, 3]}, "items": [{"id": "p_2101", "content": "Carmustine [SEP] A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other ma", "score": 1, "type": null, "tokenized_content": [2, 2279, 23084, 4425, 3, 43, 2024, 17, 4048, 3193, 12720, 28912, 29128, 9969, 5899, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 3068, 3861, 1930, 3425, 2303, 2488, 3]}]}
{"query": {"id": "q_2102", "content": "malignant gliomas [SEP]  advantage over intravenous administration for the treatment of malignant gliomas. Thirty-six patients were treated with BCNU every 6 to 8 weeks,", "tokenized_content": [2, 6558, 17083, 3, 6607, 2338, 7307, 4183, 1958, 1920, 2311, 1927, 6558, 17083, 18, 9942, 17, 3798, 2132, 1985, 2868, 1956, 6452, 1022, 1032, 4808, 26, 1942, 28, 3625, 16, 3]}, "items": [{"id": "p_2102", "content": "Glioma [SEP] Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymo", "score": 1, "type": null, "tokenized_content": [2, 10683, 3, 8867, 1930, 6558, 4101, 7580, 2433, 15347, 3595, 2037, 10786, 2094, 12, 51, 18, 47, 18, 16, 8948, 16, 19279, 16, 1930, 27222, 1037, 3]}]}
{"query": {"id": "q_2103", "content": "astrocytomas [SEP] mg/sq m body surface area. Twelve patients with Grade III or IV astrocytomas were treated after partial resection of the tumor without prior", "tokenized_content": [2, 29941, 1036, 3, 2786, 19, 14015, 55, 3362, 3154, 3403, 18, 12367, 2132, 1956, 4927, 4337, 2014, 4370, 29941, 1036, 1985, 2868, 2256, 5740, 6953, 1927, 1920, 2798, 2979, 3432, 3]}, "items": [{"id": "p_2103", "content": "Astrocytoma [SEP] Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic", "score": 1, "type": null, "tokenized_content": [2, 29941, 3, 15347, 1927, 1920, 3068, 1930, 6071, 6670, 3595, 2037, 10786, 2094, 2154, 5304, 2037, 15055, 8867, 4952, 1942, 3626, 25213, 3]}]}
{"query": {"id": "q_2104", "content": "tumor [SEP]  or IV astrocytomas were treated after partial resection of the tumor without prior radiation therapy. After two to seven cycles of c", "tokenized_content": [2, 2798, 3, 2014, 4370, 29941, 1036, 1985, 2868, 2256, 5740, 6953, 1927, 1920, 2798, 2979, 3432, 5442, 3181, 18, 2256, 2288, 1942, 5260, 6355, 1927, 45, 3]}, "items": [{"id": "p_2104", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_2105", "content": "edema [SEP] , nine patients showed a decrease in tumor size and surrounding edema on contrast-enhanced computerized tomography scans. In the nine", "tokenized_content": [2, 10144, 3, 16, 6360, 2132, 2594, 43, 3714, 1922, 2798, 3081, 1930, 7510, 10144, 1990, 3320, 17, 4256, 17206, 7876, 8581, 18, 1922, 1920, 6360, 3]}, "items": [{"id": "p_2105", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_2106", "content": "loss of vision [SEP] NU. A delayed complication in nine patients has been unilateral loss of vision secondary to a retinal vasculitis. The frequency of visual loss", "tokenized_content": [2, 3257, 1927, 9266, 3, 13232, 18, 43, 7083, 9388, 1922, 6360, 2132, 2258, 2252, 12059, 3257, 1927, 9266, 4067, 1942, 43, 6943, 21548, 18, 1920, 3528, 1927, 3737, 3257, 3]}, "items": [{"id": "p_2106", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_2107", "content": "retinal vasculitis [SEP] nine patients has been unilateral loss of vision secondary to a retinal vasculitis. The frequency of visual loss decreased after the concentration", "tokenized_content": [2, 6943, 21548, 3, 6360, 2132, 2258, 2252, 12059, 3257, 1927, 9266, 4067, 1942, 43, 6943, 21548, 18, 1920, 3528, 1927, 3737, 3257, 3261, 2256, 1920, 3110, 3]}, "items": [{"id": "p_2107", "content": "Retinal Vasculitis [SEP] Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPL", "score": 1, "type": null, "tokenized_content": [2, 6943, 21548, 3, 4531, 1927, 1920, 6943, 13040, 1956, 3425, 5092, 2710, 7465, 2573, 31, 13711, 22045, 16, 5510, 31, 20677, 1024, 3]}]}
{"query": {"id": "q_2108", "content": "visual loss [SEP] s of vision secondary to a retinal vasculitis. The frequency of visual loss decreased after the concentration of the ethanol diluent was lo", "tokenized_content": [2, 3737, 3257, 3, 61, 1927, 9266, 4067, 1942, 43, 6943, 21548, 18, 1920, 3528, 1927, 3737, 3257, 3261, 2256, 1920, 3110, 1927, 1920, 5757, 4333, 12044, 1982, 3004, 3]}, "items": [{"id": "p_2108", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_2109", "content": "ethanol [SEP] equency of visual loss decreased after the concentration of the ethanol diluent was lowered.", "tokenized_content": [2, 5757, 3, 3009, 2589, 1927, 3737, 3257, 3261, 2256, 1920, 3110, 1927, 1920, 5757, 4333, 12044, 1982, 13786, 18, 3]}, "items": [{"id": "p_2109", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_2110", "content": "noradrenaline [SEP] Blood pressure response to chronic low-dose intrarenal noradrenaline infusion in conscious rats.", "tokenized_content": [2, 22636, 3, 2877, 3772, 2644, 1942, 3724, 2330, 17, 3253, 5153, 2825, 1923, 22636, 7386, 1922, 11993, 3615, 18, 3]}, "items": [{"id": "p_2110", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_2111", "content": "Sodium chloride [SEP] Sodium chloride solution (0.9%) or noradrenaline in doses of 4, 12 and 36 micro", "tokenized_content": [2, 5227, 9140, 3, 5227, 9140, 3331, 12, 20, 18, 29, 9, 13, 2014, 22636, 1922, 5312, 1927, 24, 16, 2369, 1930, 3480, 2703, 3]}, "items": [{"id": "p_2111", "content": "Sodium Chloride [SEP] A ubiquitous sodium salt that is commonly used to season food.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 9140, 3, 43, 15498, 5227, 7012, 1988, 1977, 5384, 2251, 1942, 9520, 3959, 18, 3]}]}
{"query": {"id": "q_2112", "content": "noradrenaline [SEP] Sodium chloride solution (0.9%) or noradrenaline in doses of 4, 12 and 36 micrograms h-1 kg-1 was infused for fi", "tokenized_content": [2, 22636, 3, 5227, 9140, 3331, 12, 20, 18, 29, 9, 13, 2014, 22636, 1922, 5312, 1927, 24, 16, 2369, 1930, 3480, 13362, 50, 17, 21, 3621, 17, 21, 1982, 15610, 3]}, "items": [{"id": "p_2112", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_2113", "content": "hypertension [SEP] one kidney removed. Intrarenal infusion of noradrenaline caused hypertension at doses which did not do so when infused intravenously. Intrar", "tokenized_content": [2, 5579, 3, 2340, 5245, 5231, 18, 5153, 2825, 1923, 7386, 1927, 22636, 4189, 5579, 2019, 5312, 2154, 2811, 2084, 2608, 2577, 2469, 15610, 15132, 18, 5153, 1005, 3]}, "items": [{"id": "p_2113", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2114", "content": "cimetidine [SEP] Age and renal clearance of cimetidine.", "tokenized_content": [2, 20090, 4988, 27099, 3, 2632, 1930, 4604, 7802, 1927, 20090, 4988, 27099, 18, 3]}, "items": [{"id": "p_2114", "content": "Cimetidine [SEP] A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacol", "score": 1, "type": null, "tokenized_content": [2, 20090, 4988, 27099, 3, 43, 14622, 8680, 1915, 16, 2176, 10362, 1954, 7042, 14622, 2743, 1942, 14622, 4881, 4086, 18, 20090, 4988, 27099, 2258, 43, 3109, 1927, 22543, 3]}]}
{"query": {"id": "q_2115", "content": "cimetidine [SEP] In 35 patients (ages 20 to 86 yr) receiving cimetidine therapeutically two serum samples and all urine formed in the i", "tokenized_content": [2, 20090, 4988, 27099, 3, 1922, 3259, 2132, 12, 7684, 2036, 1942, 5713, 13031, 13, 5962, 20090, 4988, 27099, 25058, 2288, 3256, 2785, 1930, 2136, 6960, 5333, 1922, 1920, 51, 3]}, "items": [{"id": "p_2115", "content": "Cimetidine [SEP] A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacol", "score": 1, "type": null, "tokenized_content": [2, 20090, 4988, 27099, 3, 43, 14622, 8680, 1915, 16, 2176, 10362, 1954, 7042, 14622, 2743, 1942, 14622, 4881, 4086, 18, 20090, 4988, 27099, 2258, 43, 3109, 1927, 22543, 3]}]}
{"query": {"id": "q_2116", "content": "creatinine [SEP] is of cimetidine by high-pressure liquid chromatography and for creatinine. Cimetidine clearance decreased with age. The extrapolated 6-hr", "tokenized_content": [2, 9374, 3, 1977, 1927, 20090, 4988, 27099, 2007, 2149, 17, 3772, 5875, 7100, 1930, 1958, 9374, 18, 20090, 4988, 27099, 7802, 3261, 1956, 2632, 18, 1920, 23221, 26, 17, 3668, 3]}, "items": [{"id": "p_2116", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_2117", "content": "Cimetidine [SEP] dine by high-pressure liquid chromatography and for creatinine. Cimetidine clearance decreased with age. The extrapolated 6-hr serum conce", "tokenized_content": [2, 20090, 4988, 27099, 3, 11687, 1021, 2007, 2149, 17, 3772, 5875, 7100, 1930, 1958, 9374, 18, 20090, 4988, 27099, 7802, 3261, 1956, 2632, 18, 1920, 23221, 26, 17, 3668, 3256, 3]}, "items": [{"id": "p_2117", "content": "Cimetidine [SEP] A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacol", "score": 1, "type": null, "tokenized_content": [2, 20090, 4988, 27099, 3, 43, 14622, 8680, 1915, 16, 2176, 10362, 1954, 7042, 14622, 2743, 1942, 14622, 4881, 4086, 18, 20090, 4988, 27099, 2258, 43, 3109, 1927, 22543, 3]}]}
{"query": {"id": "q_2118", "content": "dementia [SEP] f cimetidine is a saturable process. There was only one case of dementia possibly due to cimetidine (with a drug level of 1.9 microgram/", "tokenized_content": [2, 7811, 3, 48, 20090, 4988, 27099, 1977, 43, 20924, 2115, 2585, 18, 2276, 1982, 2444, 2340, 3087, 1927, 7811, 6553, 2810, 1942, 20090, 4988, 27099, 12, 1956, 43, 2838, 2237, 3]}, "items": [{"id": "p_2118", "content": "Dementia [SEP] An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occup", "score": 1, "type": null, "tokenized_content": [2, 7811, 3, 1925, 5815, 6805, 5018, 4770, 1956, 3257, 1927, 13059, 10957, 1927, 5409, 5155, 1942, 11827, 1956, 3686, 2014, 6027, 3]}]}
{"query": {"id": "q_2119", "content": "kidney disease [SEP] l 6 hr after a dose) in a group of 13 patients without liver or kidney disease who had cimetidine levels above 1.25 microgram/ml. Thus, high c", "tokenized_content": [2, 5245, 2573, 3, 54, 26, 3668, 2256, 43, 3253, 13, 1922, 43, 2210, 1927, 2590, 2132, 2979, 3568, 2014, 5245, 2573, 2746, 2430, 20090, 4988, 27099, 2428, 3538, 21, 18, 3]}, "items": [{"id": "p_2119", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2120", "content": "clear cell adenocarcinoma [SEP] Development of clear cell adenocarcinoma in DES-exposed offspring under observation.", "tokenized_content": [2, 4021, 2024, 9573, 3, 2740, 1927, 4021, 2024, 9573, 1922, 2270, 17, 4616, 9074, 2441, 5275, 18, 3]}, "items": [{"id": "p_2120", "content": "Adenocarcinoma, Clear Cell [SEP] An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three", "score": 1, "type": null, "tokenized_content": [2, 9573, 16, 4021, 2024, 3, 1925, 9573, 4378, 2007, 1920, 2990, 1927, 7155, 7763, 1927, 4021, 1930, 28229, 29813, 1024, 17, 9132, 2798, 2094, 18, 2276, 2032, 2559, 3]}]}
{"query": {"id": "q_2121", "content": "DES [SEP] Development of clear cell adenocarcinoma in DES-exposed offspring under observation.", "tokenized_content": [2, 2270, 3, 2740, 1927, 4021, 2024, 9573, 1922, 2270, 17, 4616, 9074, 2441, 5275, 18, 3]}, "items": [{"id": "p_2121", "content": "Diethylstilbestrol [SEP] A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as", "score": 1, "type": null, "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 43, 6830, 29413, 7940, 2251, 1922, 1920, 2311, 1927, 17779, 1930, 14285, 4414, 18, 2176, 1982, 2222, 2251, 22397, 1966, 3]}]}
{"query": {"id": "q_2122", "content": "clear cell adenocarcinoma [SEP] Two cases of clear cell adenocarcinoma of the vagina detected at follow-up in young women exposed in u", "tokenized_content": [2, 4021, 2024, 9573, 3, 2288, 2919, 1927, 4021, 2024, 9573, 1927, 1920, 26966, 3330, 2019, 2396, 17, 2353, 1922, 4201, 3089, 4616, 1922, 63, 3]}, "items": [{"id": "p_2122", "content": "Adenocarcinoma, Clear Cell [SEP] An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three", "score": 1, "type": null, "tokenized_content": [2, 9573, 16, 4021, 2024, 3, 1925, 9573, 4378, 2007, 1920, 2990, 1927, 7155, 7763, 1927, 4021, 1930, 28229, 29813, 1024, 17, 9132, 2798, 2094, 18, 2276, 2032, 2559, 3]}]}
{"query": {"id": "q_2123", "content": "adenocarcinoma of the vagina [SEP] Two cases of clear cell adenocarcinoma of the vagina detected at follow-up in young women exposed in utero to diethy", "tokenized_content": [2, 9573, 1927, 1920, 26966, 3, 2288, 2919, 1927, 4021, 2024, 9573, 1927, 1920, 26966, 3330, 2019, 2396, 17, 2353, 1922, 4201, 3089, 4616, 1922, 19738, 1942, 3986, 30338, 3]}, "items": [{"id": "p_2123", "content": "Vaginal Neoplasms [SEP] Tumors or cancer of the VAGINA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10120, 15347, 3, 3861, 2014, 2539, 1927, 1920, 26966, 18, 3]}]}
{"query": {"id": "q_2124", "content": "diethylstilbestrol [SEP] vagina detected at follow-up in young women exposed in utero to diethylstilbestrol are reported. One patient, aged 23, had been followed for 2 yea", "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 26966, 3330, 2019, 2396, 17, 2353, 1922, 4201, 3089, 4616, 1922, 19738, 1942, 18622, 2156, 1970, 5873, 2156, 2226, 2032, 2568, 18, 2340, 3]}, "items": [{"id": "p_2124", "content": "Diethylstilbestrol [SEP] A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as", "score": 1, "type": null, "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 43, 6830, 29413, 7940, 2251, 1922, 1920, 2311, 1927, 17779, 1930, 14285, 4414, 18, 2176, 1982, 2222, 2251, 22397, 1966, 3]}]}
{"query": {"id": "q_2125", "content": "carcinoma [SEP] Two cases of clear cell adenocarcinoma of the vagina detected at follow-up in young women exposed in u", "tokenized_content": [2, 5373, 3, 2288, 2919, 1927, 4021, 2024, 9573, 1927, 1920, 26966, 3330, 2019, 2396, 17, 2353, 1922, 4201, 3089, 4616, 1922, 63, 3]}, "items": [{"id": "p_2125", "content": "Carcinoma [SEP] A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It i", "score": 1, "type": null, "tokenized_content": [2, 5373, 3, 43, 6558, 12132, 3915, 2353, 1927, 4944, 2094, 5370, 1941, 1942, 19155, 1920, 7510, 3878, 1930, 7031, 7164, 1942, 8174, 18, 2176, 51, 3]}]}
{"query": {"id": "q_2126", "content": "Phenobarbitone [SEP] Phenobarbitone-induced enlargement of the liver in the rat: its relationship t", "tokenized_content": [2, 3037, 18854, 6827, 3, 3037, 18854, 6827, 17, 2719, 16363, 1927, 1920, 3568, 1922, 1920, 3067, 30, 2496, 3303, 62, 3]}, "items": [{"id": "p_2126", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_2127", "content": "enlargement of the liver [SEP] Phenobarbitone-induced enlargement of the liver in the rat: its relationship to carbon tetrachloride-induced ci", "tokenized_content": [2, 16363, 1927, 1920, 3568, 3, 3037, 18854, 6827, 17, 2719, 16363, 1927, 1920, 3568, 1922, 1920, 3067, 30, 2496, 3303, 1942, 5056, 12470, 11600, 2261, 17, 2719, 3371, 3]}, "items": [{"id": "p_2127", "content": "Hepatomegaly [SEP] Enlargement of the liver.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5746, 19323, 3, 16363, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2128", "content": "carbon tetrachloride [SEP] nduced enlargement of the liver in the rat: its relationship to carbon tetrachloride-induced cirrhosis.", "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 8026, 2418, 16363, 1927, 1920, 3568, 1922, 1920, 3067, 30, 2496, 3303, 1942, 5056, 12470, 11600, 2261, 17, 2719, 11260, 18, 3]}, "items": [{"id": "p_2128", "content": "Carbon Tetrachloride [SEP] A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic", "score": 1, "type": null, "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 43, 7596, 1958, 16984, 16, 27751, 16, 7511, 5089, 5675, 16, 4953, 19552, 1918, 16, 19984, 18578, 1918, 16, 1930, 28015, 16, 1930, 43, 6801, 3485, 1922, 1920, 16140, 1927, 6805, 3]}]}
{"query": {"id": "q_2129", "content": "cirrhosis [SEP] er in the rat: its relationship to carbon tetrachloride-induced cirrhosis.", "tokenized_content": [2, 11260, 3, 2668, 1922, 1920, 3067, 30, 2496, 3303, 1942, 5056, 12470, 11600, 2261, 17, 2719, 11260, 18, 3]}, "items": [{"id": "p_2129", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_2130", "content": "cirrhosis of the liver [SEP] The yield of severe cirrhosis of the liver (defined as a shrunken finely nodular liver with micronodular h", "tokenized_content": [2, 11260, 1927, 1920, 3568, 3, 1920, 4307, 1927, 4010, 11260, 1927, 1920, 3568, 12, 3608, 1966, 43, 6606, 11835, 1917, 27818, 21106, 3568, 1956, 13094, 1986, 2168, 50, 3]}, "items": [{"id": "p_2130", "content": "Liver Cirrhosis [SEP] Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably ", "score": 1, "type": null, "tokenized_content": [2, 3568, 11260, 3, 3568, 2573, 1922, 2154, 1920, 2791, 27469, 16, 1920, 10461, 4541, 12843, 16, 1930, 1920, 6095, 9335, 2162, 2252, 2309, 3458, 3]}]}
{"query": {"id": "q_2131", "content": "ascites [SEP] as a shrunken finely nodular liver with micronodular histology, ascites greater than 30 ml, plasma albumin less than 2.2 g/dl, splenome", "tokenized_content": [2, 17622, 3, 1966, 43, 6606, 11835, 1917, 27818, 21106, 3568, 1956, 13094, 1986, 2168, 10727, 16, 17622, 3430, 2254, 2627, 2646, 16, 3582, 7712, 2941, 2254, 22, 18, 22, 49, 3]}, "items": [{"id": "p_2131", "content": "Ascites [SEP] Accumulation or retention of free fluid within the peritoneal cavity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17622, 3, 4858, 2014, 7521, 1927, 3294, 5466, 2651, 1920, 10706, 8568, 18, 3]}]}
{"query": {"id": "q_2132", "content": "splenomegaly [SEP]  ascites greater than 30 ml, plasma albumin less than 2.2 g/dl, splenomegaly 2-3 times normal, and testicular atrophy approximately half nor", "tokenized_content": [2, 29707, 3, 17622, 3430, 2254, 2627, 2646, 16, 3582, 7712, 2941, 2254, 22, 18, 22, 49, 19, 5268, 16, 29707, 22, 17, 23, 3586, 2791, 16, 1930, 14781, 10260, 3993, 3]}, "items": [{"id": "p_2132", "content": "Splenomegaly [SEP] Enlargement of the spleen.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29707, 3, 16363, 1927, 1920, 8380, 18, 3]}]}
{"query": {"id": "q_2133", "content": "atrophy [SEP] ss than 2.2 g/dl, splenomegaly 2-3 times normal, and testicular atrophy approximately half normal weight) after 12 doses of carbon tetr", "tokenized_content": [2, 10260, 3, 4577, 2254, 22, 18, 22, 49, 19, 5268, 16, 29707, 22, 17, 23, 3586, 2791, 16, 1930, 14781, 10260, 3993, 4768, 2791, 3388, 13, 2256, 2369, 5312, 1927, 3]}, "items": [{"id": "p_2133", "content": "Atrophy [SEP] Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as ", "score": 1, "type": null, "tokenized_content": [2, 10260, 3, 3714, 1922, 1920, 3081, 1927, 43, 2024, 16, 2960, 16, 3090, 16, 2014, 3137, 7393, 16, 2458, 1956, 43, 5386, 1927, 6598, 2961, 2427, 1966, 3]}]}
{"query": {"id": "q_2134", "content": "carbon tetrachloride [SEP] lar atrophy approximately half normal weight) after 12 doses of carbon tetrachloride given intragastrically in the phenobarbitone-primed rat was inc", "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 6590, 10260, 3993, 4768, 2791, 3388, 13, 2256, 2369, 5312, 1927, 5056, 12470, 11600, 2261, 3258, 27911, 18318, 2169, 1922, 1920, 3037, 18854, 6827, 17, 3]}, "items": [{"id": "p_2134", "content": "Carbon Tetrachloride [SEP] A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic", "score": 1, "type": null, "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 43, 7596, 1958, 16984, 16, 27751, 16, 7511, 5089, 5675, 16, 4953, 19552, 1918, 16, 19984, 18578, 1918, 16, 1930, 28015, 16, 1930, 43, 6801, 3485, 1922, 1920, 16140, 1927, 6805, 3]}]}
{"query": {"id": "q_2135", "content": "phenobarbitone [SEP]  12 doses of carbon tetrachloride given intragastrically in the phenobarbitone-primed rat was increased from 25% to 56% by giving the initial ", "tokenized_content": [2, 3037, 18854, 6827, 3, 2369, 5312, 1927, 5056, 12470, 11600, 2261, 3258, 27911, 18318, 2169, 1922, 1920, 3037, 18854, 6827, 17, 14979, 3067, 1982, 2502, 2037, 2637, 9, 1942, 4489, 3]}, "items": [{"id": "p_2135", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_2136", "content": "enlargement of the liver [SEP]  carbon tetrachloride at the peak of the phenobarbitone-induced enlargement of the liver. At this point it was assumed that the cytochrome P450/CCl4 tox", "tokenized_content": [2, 16363, 1927, 1920, 3568, 3, 5056, 12470, 11600, 2261, 2019, 1920, 3833, 1927, 1920, 3037, 18854, 6827, 17, 2719, 16363, 1927, 1920, 3568, 18, 2019, 2052, 3575, 2176, 1982, 7696, 3]}, "items": [{"id": "p_2136", "content": "Hepatomegaly [SEP] Enlargement of the liver.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5746, 19323, 3, 16363, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2137", "content": "CCl4 [SEP] he liver. At this point it was assumed that the cytochrome P450/CCl4 toxic state was both maximal and stable. The optimal rat size t", "tokenized_content": [2, 20786, 3, 2234, 3568, 18, 2019, 2052, 3575, 2176, 1982, 7696, 1988, 1920, 9387, 12088, 19, 20786, 6161, 3360, 1982, 2321, 7275, 1930, 4700, 18, 1920, 5419, 3067, 3081, 62, 3]}, "items": [{"id": "p_2137", "content": "Carbon Tetrachloride [SEP] A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic", "score": 1, "type": null, "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 43, 7596, 1958, 16984, 16, 27751, 16, 7511, 5089, 5675, 16, 4953, 19552, 1918, 16, 19984, 18578, 1918, 16, 1930, 28015, 16, 1930, 43, 6801, 3485, 1922, 1920, 16140, 1927, 6805, 3]}]}
{"query": {"id": "q_2138", "content": "lithium [SEP] Attenuation of the lithium-induced diabetes-insipidus-like syndrome by amiloride in rats.", "tokenized_content": [2, 14330, 3, 10961, 1927, 1920, 14330, 17, 2719, 4032, 17, 2346, 2049, 22291, 17, 3189, 4741, 2007, 30374, 29189, 1922, 3615, 18, 3]}, "items": [{"id": "p_2138", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2139", "content": "diabetes-insipidus-like syndrome [SEP] Attenuation of the lithium-induced diabetes-insipidus-like syndrome by amiloride in rats.", "tokenized_content": [2, 4032, 17, 2346, 2049, 22291, 17, 3189, 4741, 3, 10961, 1927, 1920, 14330, 17, 2719, 4032, 17, 2346, 2049, 22291, 17, 3189, 4741, 2007, 30374, 29189, 1922, 3615, 18, 3]}, "items": [{"id": "p_2139", "content": "Diabetes Insipidus [SEP] A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiolog", "score": 1, "type": null, "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 43, 2573, 1988, 1977, 4378, 2007, 6439, 3674, 2636, 16, 11093, 1927, 3103, 6222, 1927, 24268, 6960, 16, 1930, 9122, 4053, 2156, 18, 8096, 2167, 3]}]}
{"query": {"id": "q_2140", "content": "amiloride [SEP] tion of the lithium-induced diabetes-insipidus-like syndrome by amiloride in rats.", "tokenized_content": [2, 30374, 29189, 3, 8685, 1916, 1927, 1920, 14330, 17, 2719, 4032, 17, 2346, 2049, 22291, 17, 3189, 4741, 2007, 30374, 29189, 1922, 3615, 18, 3]}, "items": [{"id": "p_2140", "content": "Amiloride [SEP] A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a ", "score": 1, "type": null, "tokenized_content": [2, 30374, 29189, 3, 43, 6487, 10119, 3547, 7918, 5227, 26287, 2596, 5227, 5628, 1922, 4604, 4944, 2094, 18, 2052, 3523, 15628, 43, 3]}]}
{"query": {"id": "q_2141", "content": "amiloride [SEP] The effect of amiloride on lithium-induced polydipsia and polyuria and on the lithium c", "tokenized_content": [2, 30374, 29189, 3, 1920, 2495, 1927, 30374, 29189, 1990, 14330, 17, 2719, 19534, 5689, 2126, 1930, 4286, 8754, 1930, 1990, 1920, 14330, 45, 3]}, "items": [{"id": "p_2141", "content": "Amiloride [SEP] A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a ", "score": 1, "type": null, "tokenized_content": [2, 30374, 29189, 3, 43, 6487, 10119, 3547, 7918, 5227, 26287, 2596, 5227, 5628, 1922, 4604, 4944, 2094, 18, 2052, 3523, 15628, 43, 3]}]}
{"query": {"id": "q_2142", "content": "lithium [SEP] The effect of amiloride on lithium-induced polydipsia and polyuria and on the lithium concentratio", "tokenized_content": [2, 14330, 3, 1920, 2495, 1927, 30374, 29189, 1990, 14330, 17, 2719, 19534, 5689, 2126, 1930, 4286, 8754, 1930, 1990, 1920, 14330, 2587, 1968, 1037, 3]}, "items": [{"id": "p_2142", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2143", "content": "polydipsia [SEP] The effect of amiloride on lithium-induced polydipsia and polyuria and on the lithium concentration in the plasma, br", "tokenized_content": [2, 19534, 5689, 2126, 3, 1920, 2495, 1927, 30374, 29189, 1990, 14330, 17, 2719, 19534, 5689, 2126, 1930, 4286, 8754, 1930, 1990, 1920, 14330, 3110, 1922, 1920, 3582, 16, 2387, 3]}, "items": [{"id": "p_2143", "content": "Polydipsia [SEP] Excessive thirst manifested by excessive fluid intake. It is characteristic of many diseases such as DIABETES MELLITUS; DIABETES", "score": 1, "type": null, "tokenized_content": [2, 19534, 5689, 2126, 3, 9122, 4053, 2156, 16687, 2007, 9122, 5466, 5240, 18, 2176, 1977, 6293, 1927, 3086, 3902, 2427, 1966, 4032, 9695, 31, 4032, 3]}]}
{"query": {"id": "q_2144", "content": "polyuria [SEP] The effect of amiloride on lithium-induced polydipsia and polyuria and on the lithium concentration in the plasma, brain, kidney, ", "tokenized_content": [2, 4286, 8754, 3, 1920, 2495, 1927, 30374, 29189, 1990, 14330, 17, 2719, 19534, 5689, 2126, 1930, 4286, 8754, 1930, 1990, 1920, 14330, 3110, 1922, 1920, 3582, 16, 3068, 16, 5245, 3]}, "items": [{"id": "p_2144", "content": "Polyuria [SEP] Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABET", "score": 1, "type": null, "tokenized_content": [2, 4286, 8754, 3, 3674, 2636, 1927, 43, 3103, 3776, 1927, 6960, 1956, 1925, 2760, 1922, 7075, 3528, 16, 5384, 3945, 1922, 4032, 12, 4032, 9695, 31, 3517, 1946, 3]}]}
{"query": {"id": "q_2145", "content": "LiCl [SEP]  blood cells was investigated in rats, chronically treated with LiCl. Amiloride reduced the drinking and urine volume of rats in an ", "tokenized_content": [2, 27347, 3, 2877, 2094, 1982, 3845, 1922, 3615, 16, 16132, 2868, 1956, 27347, 18, 30374, 29189, 3028, 1920, 7444, 1930, 6960, 3776, 1927, 3615, 1922, 1925, 3]}, "items": [{"id": "p_2145", "content": "Lithium Chloride [SEP] A salt of lithium that has been used experimentally as an immunomodulator.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14330, 9140, 3, 43, 7012, 1927, 14330, 1988, 2258, 2252, 2251, 9568, 1966, 1925, 15345, 13505, 18, 3]}]}
{"query": {"id": "q_2146", "content": "Amiloride [SEP]  cells was investigated in rats, chronically treated with LiCl. Amiloride reduced the drinking and urine volume of rats in an acute (6 or", "tokenized_content": [2, 30374, 29189, 3, 2094, 1982, 3845, 1922, 3615, 16, 16132, 2868, 1956, 27347, 18, 30374, 29189, 3028, 1920, 7444, 1930, 6960, 3776, 1927, 3615, 1922, 1925, 3939, 12, 26, 2014, 3]}, "items": [{"id": "p_2146", "content": "Amiloride [SEP] A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a ", "score": 1, "type": null, "tokenized_content": [2, 30374, 29189, 3, 43, 6487, 10119, 3547, 7918, 5227, 26287, 2596, 5227, 5628, 1922, 4604, 4944, 2094, 18, 2052, 3523, 15628, 43, 3]}]}
{"query": {"id": "q_2147", "content": "diabetes-insipidus-like syndrome [SEP]  In all the experiments, the attenuation of the lithium-induced diabetes-insipidus-like syndrome by amiloride was accompanied by a reduction of the ratio betwee", "tokenized_content": [2, 4032, 17, 2346, 2049, 22291, 17, 3189, 4741, 3, 1922, 2136, 1920, 3144, 16, 1920, 10961, 1927, 1920, 14330, 17, 2719, 4032, 17, 2346, 2049, 22291, 17, 3189, 4741, 2007, 3]}, "items": [{"id": "p_2147", "content": "Diabetes Insipidus [SEP] A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiolog", "score": 1, "type": null, "tokenized_content": [2, 4032, 2346, 2049, 22291, 3, 43, 2573, 1988, 1977, 4378, 2007, 6439, 3674, 2636, 16, 11093, 1927, 3103, 6222, 1927, 24268, 6960, 16, 1930, 9122, 4053, 2156, 18, 8096, 2167, 3]}]}
{"query": {"id": "q_2148", "content": "potassium [SEP] ulla and its levels in the blood and an elevation in the plasma potassium level. It is concluded that acute amiloride administration to l", "tokenized_content": [2, 9057, 3, 3570, 5148, 1930, 2496, 2428, 1922, 1920, 2877, 1930, 1925, 8644, 1922, 1920, 3582, 9057, 2237, 18, 2176, 1977, 7903, 1988, 3939, 30374, 29189, 4183, 1942, 54, 3]}, "items": [{"id": "p_2148", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_2149", "content": "alprazolam [SEP] Safety and side-effects of alprazolam. Controlled study in agoraphobia with panic disorder.", "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 5407, 1930, 4159, 17, 2564, 1927, 14089, 5524, 13642, 10082, 18, 4642, 2161, 1922, 11511, 5524, 2102, 18311, 1956, 21820, 4770, 18, 3]}, "items": [{"id": "p_2149", "content": "Alprazolam [SEP] A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC ", "score": 1, "type": null, "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 43, 5083, 10457, 14601, 18774, 2053, 3547, 1956, 2246, 1928, 18068, 3152, 1930, 28514, 17, 25810, 3153, 7728, 16, 1988, 1977, 15860, 1922, 1920, 2311, 1927, 21820, 3]}]}
{"query": {"id": "q_2150", "content": "agoraphobia [SEP] Safety and side-effects of alprazolam. Controlled study in agoraphobia with panic disorder.", "tokenized_content": [2, 11511, 5524, 2102, 18311, 3, 5407, 1930, 4159, 17, 2564, 1927, 14089, 5524, 13642, 10082, 18, 4642, 2161, 1922, 11511, 5524, 2102, 18311, 1956, 21820, 4770, 18, 3]}, "items": [{"id": "p_2150", "content": "Agoraphobia [SEP] Obsessive, persistent, intense fear of open places.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11511, 5524, 2102, 18311, 3, 25555, 16, 7733, 16, 10702, 8196, 1927, 4437, 14412, 18, 3]}]}
{"query": {"id": "q_2151", "content": "panic disorder [SEP] ide-effects of alprazolam. Controlled study in agoraphobia with panic disorder.", "tokenized_content": [2, 21820, 4770, 3, 9043, 17, 2564, 1927, 14089, 5524, 13642, 10082, 18, 4642, 2161, 1922, 11511, 5524, 2102, 18311, 1956, 21820, 4770, 18, 3]}, "items": [{"id": "p_2151", "content": "Panic Disorder [SEP] A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin wi", "score": 1, "type": null, "tokenized_content": [2, 21820, 4770, 3, 43, 2601, 1927, 5592, 4770, 4378, 2007, 9892, 21820, 15413, 1988, 4691, 4814, 2014, 16, 9671, 16, 3967, 18, 21820, 15413, 11763, 11980, 3]}]}
{"query": {"id": "q_2152", "content": "benzodiazepines [SEP] BACKGROUND: The widespread use of benzodiazepines has led to increasing recognition of their unwanted effects. Th", "tokenized_content": [2, 26555, 3, 3872, 30, 1920, 9360, 2485, 1927, 26555, 2258, 4866, 1942, 3605, 5708, 1927, 2310, 20140, 2564, 18, 1913, 3]}, "items": [{"id": "p_2152", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_2153", "content": "alprazolam [SEP] creasing recognition of their unwanted effects. The efficacy of alprazolam and placebo in panic disorder with agoraphobia, and the side-ef", "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 3478, 3274, 5708, 1927, 2310, 20140, 2564, 18, 1920, 4348, 1927, 14089, 5524, 13642, 10082, 1930, 5936, 1922, 21820, 4770, 1956, 11511, 5524, 2102, 18311, 3]}, "items": [{"id": "p_2153", "content": "Alprazolam [SEP] A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC ", "score": 1, "type": null, "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 43, 5083, 10457, 14601, 18774, 2053, 3547, 1956, 2246, 1928, 18068, 3152, 1930, 28514, 17, 25810, 3153, 7728, 16, 1988, 1977, 15860, 1922, 1920, 2311, 1927, 21820, 3]}]}
{"query": {"id": "q_2154", "content": "panic disorder [SEP] eir unwanted effects. The efficacy of alprazolam and placebo in panic disorder with agoraphobia, and the side-effect and adverse effect profil", "tokenized_content": [2, 21820, 4770, 3, 16101, 1005, 20140, 2564, 18, 1920, 4348, 1927, 14089, 5524, 13642, 10082, 1930, 5936, 1922, 21820, 4770, 1956, 11511, 5524, 2102, 18311, 16, 1930, 1920, 4159, 17, 3]}, "items": [{"id": "p_2154", "content": "Panic Disorder [SEP] A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin wi", "score": 1, "type": null, "tokenized_content": [2, 21820, 4770, 3, 43, 2601, 1927, 5592, 4770, 4378, 2007, 9892, 21820, 15413, 1988, 4691, 4814, 2014, 16, 9671, 16, 3967, 18, 21820, 15413, 11763, 11980, 3]}]}
{"query": {"id": "q_2155", "content": "agoraphobia [SEP] . The efficacy of alprazolam and placebo in panic disorder with agoraphobia, and the side-effect and adverse effect profiles of both drug g", "tokenized_content": [2, 11511, 5524, 2102, 18311, 3, 18, 1920, 4348, 1927, 14089, 5524, 13642, 10082, 1930, 5936, 1922, 21820, 4770, 1956, 11511, 5524, 2102, 18311, 16, 1930, 1920, 4159, 17, 2495, 1930, 3]}, "items": [{"id": "p_2155", "content": "Agoraphobia [SEP] Obsessive, persistent, intense fear of open places.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11511, 5524, 2102, 18311, 3, 25555, 16, 7733, 16, 10702, 8196, 1927, 4437, 14412, 18, 3]}]}
{"query": {"id": "q_2156", "content": "depression [SEP] azolam patients developed more adverse reactions (21% v. 0%) of depression, enuresis, disinhibition and aggression; and more side-effects,", "tokenized_content": [2, 4621, 3, 27381, 10082, 2132, 3530, 2253, 5246, 5298, 12, 2900, 9, 64, 18, 20, 9, 13, 1927, 4621, 16, 2066, 27718, 16, 16966, 24178, 1930, 13116, 31, 1930, 2253, 3]}, "items": [{"id": "p_2156", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_2157", "content": "enuresis [SEP] nts developed more adverse reactions (21% v. 0%) of depression, enuresis, disinhibition and aggression; and more side-effects, particula", "tokenized_content": [2, 2066, 27718, 3, 17969, 3530, 2253, 5246, 5298, 12, 2900, 9, 64, 18, 20, 9, 13, 1927, 4621, 16, 2066, 27718, 16, 16966, 24178, 1930, 13116, 31, 1930, 2253, 4159, 3]}, "items": [{"id": "p_2157", "content": "Enuresis [SEP] Involuntary discharge of URINE after expected age of completed development of urinary control. This can happen during the daytim", "score": 1, "type": null, "tokenized_content": [2, 2066, 27718, 3, 28493, 7695, 1927, 6960, 2256, 4100, 2632, 1927, 5721, 2740, 1927, 7075, 2285, 18, 2052, 2112, 20492, 2409, 1920, 3007, 2265, 3]}]}
{"query": {"id": "q_2158", "content": "aggression [SEP] eactions (21% v. 0%) of depression, enuresis, disinhibition and aggression; and more side-effects, particularly sedation, irritability, im", "tokenized_content": [2, 13116, 3, 27848, 3104, 12, 2900, 9, 64, 18, 20, 9, 13, 1927, 4621, 16, 2066, 27718, 16, 16966, 24178, 1930, 13116, 31, 1930, 2253, 4159, 17, 2564, 16, 4443, 3]}, "items": [{"id": "p_2158", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_2159", "content": "irritability [SEP] n and aggression; and more side-effects, particularly sedation, irritability, impaired memory, weight loss and ataxia. Side-effects tended t", "tokenized_content": [2, 29534, 3, 56, 1930, 13116, 31, 1930, 2253, 4159, 17, 2564, 16, 4443, 15263, 16, 29534, 16, 5761, 4525, 16, 3388, 3257, 1930, 17698, 18, 4159, 17, 2564, 10587, 62, 3]}, "items": [{"id": "p_2159", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_2160", "content": "impaired memory [SEP] on; and more side-effects, particularly sedation, irritability, impaired memory, weight loss and ataxia. Side-effects tended to diminish during", "tokenized_content": [2, 5761, 4525, 3, 1990, 31, 1930, 2253, 4159, 17, 2564, 16, 4443, 15263, 16, 29534, 16, 5761, 4525, 16, 3388, 3257, 1930, 17698, 18, 4159, 17, 2564, 10587, 1942, 16072, 3]}, "items": [{"id": "p_2160", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_2161", "content": "weight loss [SEP] -effects, particularly sedation, irritability, impaired memory, weight loss and ataxia. Side-effects tended to diminish during treatment bu", "tokenized_content": [2, 3388, 3257, 3, 17, 2564, 16, 4443, 15263, 16, 29534, 16, 5761, 4525, 16, 3388, 3257, 1930, 17698, 18, 4159, 17, 2564, 10587, 1942, 16072, 2409, 2311, 3168, 3]}, "items": [{"id": "p_2161", "content": "Weight Loss [SEP] Decrease in existing BODY WEIGHT.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3388, 3257, 3, 3714, 1922, 6124, 3362, 3388, 18, 3]}]}
{"query": {"id": "q_2162", "content": "ataxia [SEP] ularly sedation, irritability, impaired memory, weight loss and ataxia. Side-effects tended to diminish during treatment but remained ", "tokenized_content": [2, 17698, 3, 3570, 2820, 15263, 16, 29534, 16, 5761, 4525, 16, 3388, 3257, 1930, 17698, 18, 4159, 17, 2564, 10587, 1942, 16072, 2409, 2311, 2308, 5410, 3]}, "items": [{"id": "p_2162", "content": "Ataxia [SEP] Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes,", "score": 1, "type": null, "tokenized_content": [2, 17698, 3, 6159, 1927, 1920, 3682, 1942, 2385, 6689, 1954, 11651, 13225, 8264, 18, 2052, 2625, 2278, 4081, 1920, 14054, 16, 13717, 16, 7127, 16, 3]}]}
{"query": {"id": "q_2163", "content": "Alprazolam [SEP] t week 8. Despite this, the drop-out rate was low. CONCLUSIONS: Alprazolam caused side-effects and adverse effects during treatment but ma", "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 62, 2982, 28, 18, 4281, 2052, 16, 1920, 7086, 17, 2397, 2769, 1982, 2330, 18, 4355, 30, 14089, 5524, 13642, 10082, 4189, 4159, 17, 2564, 3]}, "items": [{"id": "p_2163", "content": "Alprazolam [SEP] A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC ", "score": 1, "type": null, "tokenized_content": [2, 14089, 5524, 13642, 10082, 3, 43, 5083, 10457, 14601, 18774, 2053, 3547, 1956, 2246, 1928, 18068, 3152, 1930, 28514, 17, 25810, 3153, 7728, 16, 1988, 1977, 15860, 1922, 1920, 2311, 1927, 21820, 3]}]}
{"query": {"id": "q_2164", "content": "Dup 753 [SEP] Dup 753 prevents the development of puromycin aminonucleoside-induced n", "tokenized_content": [2, 25139, 4089, 1010, 3, 25139, 4089, 1010, 10299, 1920, 2740, 1927, 19750, 3835, 1022, 2626, 8028, 17, 2719, 56, 3]}, "items": [{"id": "p_2164", "content": "Losartan [SEP] An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.", "score": 1, "type": null, "tokenized_content": [2, 28393, 3, 1925, 8151, 1927, 10814, 2601, 21, 3148, 1956, 16439, 2455, 2810, 1942, 1920, 3028, 3477, 1924, 2495, 1927, 10814, 2890, 18, 3]}]}
{"query": {"id": "q_2165", "content": "puromycin aminonucleoside [SEP] Dup 753 prevents the development of puromycin aminonucleoside-induced nephrosis.", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 25139, 4089, 1010, 10299, 1920, 2740, 1927, 19750, 3835, 1022, 2626, 8028, 17, 2719, 7737, 4870, 18, 3]}, "items": [{"id": "p_2165", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_2166", "content": "nephrosis [SEP] 3 prevents the development of puromycin aminonucleoside-induced nephrosis.", "tokenized_content": [2, 7737, 4870, 3, 23, 10299, 1920, 2740, 1927, 19750, 3835, 1022, 2626, 8028, 17, 2719, 7737, 4870, 18, 3]}, "items": [{"id": "p_2166", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_2167", "content": "nephrotic syndromes [SEP] The appearance of nephrotic syndromes such as proteinuria, hypoalbuminemia, hypercholesterolemia and ", "tokenized_content": [2, 29646, 12688, 3, 1920, 7818, 1927, 29646, 12688, 2427, 1966, 15831, 16, 14395, 15721, 3847, 16, 22862, 1930, 3]}, "items": [{"id": "p_2167", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_2168", "content": "proteinuria [SEP] The appearance of nephrotic syndromes such as proteinuria, hypoalbuminemia, hypercholesterolemia and increase in blood ni", "tokenized_content": [2, 15831, 3, 1920, 7818, 1927, 29646, 12688, 2427, 1966, 15831, 16, 14395, 15721, 3847, 16, 22862, 1930, 2760, 1922, 2877, 7781, 3]}, "items": [{"id": "p_2168", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2169", "content": "hypoalbuminemia [SEP] The appearance of nephrotic syndromes such as proteinuria, hypoalbuminemia, hypercholesterolemia and increase in blood nitrogen urea, indu", "tokenized_content": [2, 14395, 15721, 3847, 3, 1920, 7818, 1927, 29646, 12688, 2427, 1966, 15831, 16, 14395, 15721, 3847, 16, 22862, 1930, 2760, 1922, 2877, 6634, 10505, 16, 2063, 1032, 3]}, "items": [{"id": "p_2169", "content": "Hypoalbuminemia [SEP] A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased h", "score": 1, "type": null, "tokenized_content": [2, 14395, 15721, 3847, 3, 43, 2625, 1922, 2154, 7712, 2237, 1922, 2877, 12, 3256, 7712, 13, 1977, 4535, 1920, 2791, 3109, 18, 14395, 15721, 3847, 2278, 1998, 2810, 1942, 3261, 50, 3]}]}
{"query": {"id": "q_2170", "content": "hypercholesterolemia [SEP] ce of nephrotic syndromes such as proteinuria, hypoalbuminemia, hypercholesterolemia and increase in blood nitrogen urea, induced in rats by injecti", "tokenized_content": [2, 22862, 3, 5827, 1927, 29646, 12688, 2427, 1966, 15831, 16, 14395, 15721, 3847, 16, 22862, 1930, 2760, 1922, 2877, 6634, 10505, 16, 2719, 1922, 3615, 2007, 27270, 1033, 3]}, "items": [{"id": "p_2170", "content": "Hypercholesterolemia [SEP] A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th per", "score": 1, "type": null, "tokenized_content": [2, 22862, 3, 43, 2625, 1956, 20756, 2149, 2428, 1927, 5463, 1922, 1920, 2877, 18, 2176, 1977, 3608, 1966, 43, 5463, 3113, 15547, 1920, 28463, 2079, 3]}]}
{"query": {"id": "q_2171", "content": "blood nitrogen urea [SEP] teinuria, hypoalbuminemia, hypercholesterolemia and increase in blood nitrogen urea, induced in rats by injection of puromycin aminonucleoside was ", "tokenized_content": [2, 2877, 6634, 10505, 3, 3602, 1921, 8754, 16, 14395, 15721, 3847, 16, 22862, 1930, 2760, 1922, 2877, 6634, 10505, 16, 2719, 1922, 3615, 2007, 4107, 1927, 19750, 3835, 1022, 2626, 3]}, "items": [{"id": "p_2171", "content": "Blood Urea Nitrogen [SEP] The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% highe", "score": 1, "type": null, "tokenized_content": [2, 2877, 10505, 6634, 3, 1920, 10505, 3110, 1927, 1920, 2877, 9662, 1922, 4430, 1927, 6634, 3919, 18, 3256, 12, 3582, 13, 10505, 6634, 1977, 3993, 2369, 9, 2149, 1021, 3]}]}
{"query": {"id": "q_2172", "content": "puromycin aminonucleoside [SEP] ncrease in blood nitrogen urea, induced in rats by injection of puromycin aminonucleoside was markedly inhibited by oral administration of Dup 753 (losar", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 16122, 18013, 1021, 1922, 2877, 6634, 10505, 16, 2719, 1922, 3615, 2007, 4107, 1927, 19750, 3835, 1022, 2626, 8028, 1982, 7686, 5069, 2007, 4726, 3]}, "items": [{"id": "p_2172", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_2173", "content": "Dup 753 [SEP] minonucleoside was markedly inhibited by oral administration of Dup 753 (losartan), a novel angiotensin II receptor antagonist, at a do", "tokenized_content": [2, 25139, 4089, 1010, 3, 2360, 5551, 8028, 1982, 7686, 5069, 2007, 4726, 4183, 1927, 25139, 4089, 1010, 12, 28393, 13, 16, 43, 4008, 10814, 2890, 3148, 8151, 16, 2019, 43, 3]}, "items": [{"id": "p_2173", "content": "Losartan [SEP] An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.", "score": 1, "type": null, "tokenized_content": [2, 28393, 3, 1925, 8151, 1927, 10814, 2601, 21, 3148, 1956, 16439, 2455, 2810, 1942, 1920, 3028, 3477, 1924, 2495, 1927, 10814, 2890, 18, 3]}]}
{"query": {"id": "q_2174", "content": "losartan [SEP] oside was markedly inhibited by oral administration of Dup 753 (losartan), a novel angiotensin II receptor antagonist, at a dose of 1 or", "tokenized_content": [2, 28393, 3, 3125, 2261, 1982, 7686, 5069, 2007, 4726, 4183, 1927, 25139, 4089, 1010, 12, 28393, 13, 16, 43, 4008, 10814, 2890, 3148, 8151, 16, 2019, 43, 3253, 1927, 21, 3]}, "items": [{"id": "p_2174", "content": "Losartan [SEP] An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.", "score": 1, "type": null, "tokenized_content": [2, 28393, 3, 1925, 8151, 1927, 10814, 2601, 21, 3148, 1956, 16439, 2455, 2810, 1942, 1920, 3028, 3477, 1924, 2495, 1927, 10814, 2890, 18, 3]}]}
{"query": {"id": "q_2175", "content": "angiotensin II [SEP] inhibited by oral administration of Dup 753 (losartan), a novel angiotensin II receptor antagonist, at a dose of 1 or 2 mg/kg per day. The res", "tokenized_content": [2, 10814, 2890, 3, 5069, 2007, 4726, 4183, 1927, 25139, 4089, 1010, 12, 28393, 13, 16, 43, 4008, 10814, 2890, 3148, 8151, 16, 2019, 43, 3253, 1927, 21, 2014, 22, 2786, 3]}, "items": [{"id": "p_2175", "content": "Angiotensin II [SEP] An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino aci", "score": 1, "type": null, "tokenized_content": [2, 10814, 2890, 3, 1925, 5843, 24010, 1988, 1977, 43, 6828, 2308, 22001, 28404, 2684, 18, 2176, 1977, 4152, 2037, 10814, 51, 2256, 1920, 6025, 1927, 2288, 3835, 2000, 1033, 3]}]}
{"query": {"id": "q_2176", "content": "angiotensin [SEP] inhibited by oral administration of Dup 753 (losartan), a novel angiotensin II receptor antagonist, at a dose of 1 or 2 mg/kg per day. The ", "tokenized_content": [2, 10814, 3, 5069, 2007, 4726, 4183, 1927, 25139, 4089, 1010, 12, 28393, 13, 16, 43, 4008, 10814, 2890, 3148, 8151, 16, 2019, 43, 3253, 1927, 21, 2014, 22, 2786, 19, 3]}, "items": [{"id": "p_2176", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_2177", "content": "nephrosis [SEP]  system in the development of puromycin aminonucleoside-induced nephrosis.", "tokenized_content": [2, 7737, 4870, 3, 2433, 1922, 1920, 2740, 1927, 19750, 3835, 1022, 2626, 8028, 17, 2719, 7737, 4870, 18, 3]}, "items": [{"id": "p_2177", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_2178", "content": "Sodium bicarbonate [SEP] Sodium bicarbonate alleviates penile pain induced by intracavernous injections for", "tokenized_content": [2, 5227, 16106, 3, 5227, 16106, 18312, 1036, 22609, 3594, 2719, 2007, 4245, 14666, 11873, 1957, 8775, 1958, 3]}, "items": [{"id": "p_2178", "content": "Sodium Bicarbonate [SEP] A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in", "score": 1, "type": null, "tokenized_content": [2, 5227, 16106, 3, 43, 4511, 16, 14631, 10201, 1988, 1977, 5384, 2251, 1966, 43, 2087, 23811, 5899, 16, 1925, 15428, 24549, 14682, 16, 5510, 25178, 14151, 1930, 1922, 3]}]}
{"query": {"id": "q_2179", "content": "penile pain [SEP] Sodium bicarbonate alleviates penile pain induced by intracavernous injections for erectile dysfunction.", "tokenized_content": [2, 22609, 3594, 3, 5227, 16106, 18312, 1036, 22609, 3594, 2719, 2007, 4245, 14666, 11873, 1957, 8775, 1958, 24686, 5273, 18, 3]}, "items": [{"id": "p_2179", "content": "Dyspareunia [SEP] Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14633, 2768, 1983, 2126, 3, 7457, 13473, 3594, 6966, 2409, 16, 3119, 16, 2014, 2256, 5702, 20689, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_2180", "content": "erectile dysfunction [SEP] alleviates penile pain induced by intracavernous injections for erectile dysfunction.", "tokenized_content": [2, 24686, 5273, 3, 18312, 1036, 22609, 3594, 2719, 2007, 4245, 14666, 11873, 1957, 8775, 1958, 24686, 5273, 18, 3]}, "items": [{"id": "p_2180", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_2181", "content": "penile pain [SEP] In an attempt to determine whether penile pain associated with intracorporeal injections could be due to the a", "tokenized_content": [2, 22609, 3594, 3, 1922, 1925, 9289, 1942, 3415, 3053, 22609, 3594, 2458, 1956, 4245, 24680, 8775, 2578, 1998, 2810, 1942, 1920, 43, 3]}, "items": [{"id": "p_2181", "content": "Dyspareunia [SEP] Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14633, 2768, 1983, 2126, 3, 7457, 13473, 3594, 6966, 2409, 16, 3119, 16, 2014, 2256, 5702, 20689, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_2182", "content": "sodium bicarbonate [SEP] owing intracorporeal injections with or without the addition of sodium bicarbonate to the intracorporeal medications. A total of 38 consecutive pa", "tokenized_content": [2, 5227, 16106, 3, 10762, 4245, 24680, 8775, 1956, 2014, 2979, 1920, 2459, 1927, 5227, 16106, 1942, 1920, 4245, 24680, 7719, 18, 43, 2698, 1927, 3738, 7351, 3838, 3]}, "items": [{"id": "p_2182", "content": "Sodium Bicarbonate [SEP] A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in", "score": 1, "type": null, "tokenized_content": [2, 5227, 16106, 3, 43, 4511, 16, 14631, 10201, 1988, 1977, 5384, 2251, 1966, 43, 2087, 23811, 5899, 16, 1925, 15428, 24549, 14682, 16, 5510, 25178, 14151, 1930, 1922, 3]}]}
{"query": {"id": "q_2183", "content": "impotence [SEP] tal of 38 consecutive patients who presented to our clinic with impotence received 0.2 ml. of a combination of 3 drugs: 6 mg. papaverine,", "tokenized_content": [2, 2754, 7229, 15895, 1021, 3, 11571, 1927, 3738, 7351, 2132, 2746, 3549, 1942, 2342, 6248, 1956, 2754, 7229, 15895, 1021, 4004, 20, 18, 22, 2646, 18, 1927, 43, 3921, 1927, 3]}, "items": [{"id": "p_2183", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_2184", "content": "papaverine [SEP] h impotence received 0.2 ml. of a combination of 3 drugs: 6 mg. papaverine, 100 micrograms. phentolamine and 10 micrograms. prostaglandin ", "tokenized_content": [2, 3860, 14666, 2053, 3, 50, 2754, 7229, 15895, 1021, 4004, 20, 18, 22, 2646, 18, 1927, 43, 3921, 1927, 23, 4195, 30, 26, 2786, 18, 3860, 14666, 2053, 16, 2813, 3]}, "items": [{"id": "p_2184", "content": "Papaverine [SEP] An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It ", "score": 1, "type": null, "tokenized_content": [2, 3860, 14666, 2053, 3, 1925, 29951, 2435, 1922, 7976, 1989, 2308, 2084, 6538, 2712, 1942, 1920, 2303, 7976, 1989, 22390, 1922, 2496, 3170, 2014, 7683, 7728, 18, 2176, 3]}]}
{"query": {"id": "q_2185", "content": "phentolamine [SEP]  of a combination of 3 drugs: 6 mg. papaverine, 100 micrograms. phentolamine and 10 micrograms. prostaglandin E1 with (pH 7.05) or without (", "tokenized_content": [2, 3037, 4575, 10082, 2053, 3, 1927, 43, 3921, 1927, 23, 4195, 30, 26, 2786, 18, 3860, 14666, 2053, 16, 2813, 13362, 18, 3037, 4575, 10082, 2053, 1930, 2119, 13362, 18, 3]}, "items": [{"id": "p_2185", "content": "Phentolamine [SEP] A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromo", "score": 1, "type": null, "tokenized_content": [2, 3037, 4575, 10082, 2053, 3, 43, 6771, 25568, 4595, 17, 13672, 8151, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 5579, 1930, 11706, 14569, 15895, 2062, 16, 30004, 1037, 3]}]}
{"query": {"id": "q_2186", "content": "prostaglandin E1 [SEP] mg. papaverine, 100 micrograms. phentolamine and 10 micrograms. prostaglandin E1 with (pH 7.05) or without (pH 4.17) the addition of sodium bica", "tokenized_content": [2, 15900, 11123, 3, 2786, 18, 3860, 14666, 2053, 16, 2813, 13362, 18, 3037, 4575, 10082, 2053, 1930, 2119, 13362, 18, 15900, 11123, 1956, 12, 2087, 27, 18, 2914, 13, 2014, 3]}, "items": [{"id": "p_2186", "content": "Alprostadil [SEP] A potent vasodilator agent that increases peripheral blood flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14089, 16289, 2713, 1024, 3, 43, 6828, 28194, 5899, 1988, 4041, 5009, 2877, 3426, 18, 3]}]}
{"query": {"id": "q_2187", "content": "octreotide [SEP] spective study of the long-term effects of somatostatin analog (octreotide) on gallbladder function and gallstone formation in Chinese acr", "tokenized_content": [2, 5843, 29351, 3, 4544, 2320, 2161, 1927, 1920, 2815, 17, 2576, 2564, 1927, 20698, 5729, 12, 5843, 29351, 13, 1990, 19358, 2347, 1930, 9354, 22727, 3337, 1922, 7185, 10428, 3]}, "items": [{"id": "p_2187", "content": "Octreotide [SEP] A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat h", "score": 1, "type": null, "tokenized_content": [2, 5843, 29351, 3, 43, 6828, 16, 2815, 17, 8290, 6830, 20698, 5843, 24010, 5729, 1988, 7042, 5512, 1927, 2905, 6365, 1930, 1977, 2251, 1942, 2297, 50, 3]}]}
{"query": {"id": "q_2188", "content": "gallstone [SEP] of somatostatin analog (octreotide) on gallbladder function and gallstone formation in Chinese acromegalic patients.", "tokenized_content": [2, 9354, 22727, 3, 1927, 20698, 5729, 12, 5843, 29351, 13, 1990, 19358, 2347, 1930, 9354, 22727, 3337, 1922, 7185, 10428, 14259, 1935, 2132, 18, 3]}, "items": [{"id": "p_2188", "content": "Gallstones [SEP] Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHI", "score": 1, "type": null, "tokenized_content": [2, 9354, 22727, 1036, 3, 5358, 14631, 25339, 1922, 1920, 13210, 6482, 16, 5394, 5333, 1922, 1920, 19358, 16, 3864, 1922, 1920, 2625, 1927, 6268, 11085, 22523, 3]}]}
{"query": {"id": "q_2189", "content": "acromegalic [SEP] ide) on gallbladder function and gallstone formation in Chinese acromegalic patients.", "tokenized_content": [2, 10428, 14259, 1935, 3, 9043, 13, 1990, 19358, 2347, 1930, 9354, 22727, 3337, 1922, 7185, 10428, 14259, 1935, 2132, 18, 3]}, "items": [{"id": "p_2189", "content": "Acromegaly [SEP] A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of", "score": 1, "type": null, "tokenized_content": [2, 10428, 19323, 3, 43, 2625, 4189, 2007, 7171, 3395, 1942, 9122, 2616, 2905, 6365, 1922, 4440, 18, 2176, 1977, 4378, 2007, 18525, 16363, 1927, 3]}]}
{"query": {"id": "q_2190", "content": "acromegaly [SEP]  examined by ultrasonography in 20 Chinese patients with active acromegaly treated with sc injection of the somatostatin analog octreotide", "tokenized_content": [2, 10428, 19323, 3, 3572, 2007, 15417, 1922, 2036, 7185, 2132, 1956, 3500, 10428, 19323, 2868, 1956, 2160, 4107, 1927, 1920, 20698, 5729, 5843, 29351, 3]}, "items": [{"id": "p_2190", "content": "Acromegaly [SEP] A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of", "score": 1, "type": null, "tokenized_content": [2, 10428, 19323, 3, 43, 2625, 4189, 2007, 7171, 3395, 1942, 9122, 2616, 2905, 6365, 1922, 4440, 18, 2176, 1977, 4378, 2007, 18525, 16363, 1927, 3]}]}
{"query": {"id": "q_2191", "content": "octreotide [SEP] acromegaly treated with sc injection of the somatostatin analog octreotide in dosages of 300-1500 micrograms/day for a mean of 24.2 +/- 13", "tokenized_content": [2, 5843, 29351, 3, 10428, 19323, 2868, 1956, 2160, 4107, 1927, 1920, 20698, 5729, 5843, 29351, 1922, 20549, 1927, 5255, 17, 15297, 13362, 19, 3007, 1958, 43, 2667, 1927, 2686, 18, 3]}, "items": [{"id": "p_2191", "content": "Octreotide [SEP] A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat h", "score": 1, "type": null, "tokenized_content": [2, 5843, 29351, 3, 43, 6828, 16, 2815, 17, 8290, 6830, 20698, 5843, 24010, 5729, 1988, 7042, 5512, 1927, 2905, 6365, 1930, 1977, 2251, 1942, 2297, 50, 3]}]}
{"query": {"id": "q_2192", "content": "gallstones [SEP] treatment with octreotide, 17 patients developed sludge, 10 had gallstones, and 1 developed acute cholecystitis requiring surgery. In all ", "tokenized_content": [2, 9354, 22727, 1036, 3, 2311, 1956, 5843, 29351, 16, 2752, 2132, 3530, 19435, 16, 2119, 2430, 9354, 22727, 1036, 16, 1930, 21, 3530, 3939, 19348, 3678, 8887, 3782, 18, 1922, 3]}, "items": [{"id": "p_2192", "content": "Gallstones [SEP] Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHI", "score": 1, "type": null, "tokenized_content": [2, 9354, 22727, 1036, 3, 5358, 14631, 25339, 1922, 1920, 13210, 6482, 16, 5394, 5333, 1922, 1920, 19358, 16, 3864, 1922, 1920, 2625, 1927, 6268, 11085, 22523, 3]}]}
{"query": {"id": "q_2193", "content": "acute cholecystitis [SEP] 7 patients developed sludge, 10 had gallstones, and 1 developed acute cholecystitis requiring surgery. In all of 7 patients examined acutely, gallb", "tokenized_content": [2, 3939, 19348, 3678, 3, 27, 2132, 3530, 19435, 16, 2119, 2430, 9354, 22727, 1036, 16, 1930, 21, 3530, 3939, 19348, 3678, 8887, 3782, 18, 1922, 2136, 1927, 27, 2132, 3572, 3]}, "items": [{"id": "p_2193", "content": "Cholecystitis, Acute [SEP] Acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gall", "score": 1, "type": null, "tokenized_content": [2, 19348, 3678, 16, 3939, 3, 3939, 4531, 1927, 1920, 19358, 4821, 18, 2176, 1977, 4378, 2007, 1920, 2990, 1927, 6900, 3594, 31, 9087, 31, 1930, 5104, 7349, 18, 9354, 3]}]}
{"query": {"id": "q_2194", "content": "depressed [SEP] ients followed for 24 weeks, gallbladder contractility remained depressed throughout therapy. After withdrawal of octreotide in 10 patien", "tokenized_content": [2, 11365, 3, 10116, 4905, 1036, 3489, 1958, 2686, 3625, 16, 19358, 17862, 5410, 11365, 5264, 3181, 18, 2256, 9594, 1927, 5843, 29351, 1922, 2119, 2091, 1917, 3]}, "items": [{"id": "p_2194", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_2195", "content": "cholecystitis [SEP] ents developed sludge, 10 had gallstones, and 1 developed acute cholecystitis requiring surgery. In all of 7 patients examined acutely, gallb", "tokenized_content": [2, 19348, 3678, 3, 8496, 1036, 3530, 19435, 16, 2119, 2430, 9354, 22727, 1036, 16, 1930, 21, 3530, 3939, 19348, 3678, 8887, 3782, 18, 1922, 2136, 1927, 27, 2132, 3572, 18141, 3]}, "items": [{"id": "p_2195", "content": "Cholecystitis [SEP] Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or ot", "score": 1, "type": null, "tokenized_content": [2, 19348, 3678, 3, 4531, 1927, 1920, 19358, 31, 4933, 4189, 2007, 6159, 1927, 9619, 3426, 16, 9354, 22727, 1036, 1922, 1920, 13210, 6482, 16, 5024, 16, 2014, 7608, 3]}]}
{"query": {"id": "q_2196", "content": "acromegalic [SEP] lstones, and cholecystitis during octreotide therapy in Chinese acromegalic patients. It is therefore very important to follow the changes ", "tokenized_content": [2, 10428, 14259, 1935, 3, 27167, 3965, 16, 1930, 19348, 3678, 2409, 5843, 29351, 3181, 1922, 7185, 10428, 14259, 1935, 2132, 18, 2176, 1977, 2955, 3345, 2715, 1942, 2396, 1920, 2840, 3]}, "items": [{"id": "p_2196", "content": "Acromegaly [SEP] A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of", "score": 1, "type": null, "tokenized_content": [2, 10428, 19323, 3, 43, 2625, 4189, 2007, 7171, 3395, 1942, 9122, 2616, 2905, 6365, 1922, 4440, 18, 2176, 1977, 4378, 2007, 18525, 16363, 1927, 3]}]}
{"query": {"id": "q_2197", "content": "levodopa [SEP] Improvement of levodopa-induced dyskinesia by propranolol in Parkinson's disease.", "tokenized_content": [2, 26723, 3, 4990, 1927, 26723, 17, 2719, 3890, 26682, 2007, 21395, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2197", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_2198", "content": "dyskinesia [SEP] Improvement of levodopa-induced dyskinesia by propranolol in Parkinson's disease.", "tokenized_content": [2, 3890, 26682, 3, 4990, 1927, 26723, 17, 2719, 3890, 26682, 2007, 21395, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2198", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2199", "content": "propranolol [SEP] Improvement of levodopa-induced dyskinesia by propranolol in Parkinson's disease.", "tokenized_content": [2, 21395, 3, 4990, 1927, 26723, 17, 2719, 3890, 26682, 2007, 21395, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2199", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_2200", "content": "Parkinson's disease [SEP] Improvement of levodopa-induced dyskinesia by propranolol in Parkinson's disease.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 4990, 1927, 26723, 17, 2719, 3890, 26682, 2007, 21395, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2200", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2201", "content": "Parkinson's disease [SEP] Seven patients suffering from Parkinson's disease (PD) with severely disabling dyskinesia received low-dose propr", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 5260, 2132, 11364, 2037, 10124, 11, 61, 2573, 12, 3203, 13, 1956, 10561, 27606, 3890, 26682, 4004, 2330, 17, 3253, 12031, 3]}, "items": [{"id": "p_2201", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2202", "content": "PD [SEP] Seven patients suffering from Parkinson's disease (PD) with severely disabling dyskinesia received low-dose propranol", "tokenized_content": [2, 3203, 3, 5260, 2132, 11364, 2037, 10124, 11, 61, 2573, 12, 3203, 13, 1956, 10561, 27606, 3890, 26682, 4004, 2330, 17, 3253, 12031, 4296, 3]}, "items": [{"id": "p_2202", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2203", "content": "dyskinesia [SEP] suffering from Parkinson's disease (PD) with severely disabling dyskinesia received low-dose propranolol as an adjunct to the currently us", "tokenized_content": [2, 3890, 26682, 3, 11364, 2037, 10124, 11, 61, 2573, 12, 3203, 13, 1956, 10561, 27606, 3890, 26682, 4004, 2330, 17, 3253, 21395, 1966, 1925, 22481, 1942, 1920, 5077, 2022, 3]}, "items": [{"id": "p_2203", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2204", "content": "propranolol [SEP] sease (PD) with severely disabling dyskinesia received low-dose propranolol as an adjunct to the currently used medical treatment. There wa", "tokenized_content": [2, 21395, 3, 6743, 1021, 12, 3203, 13, 1956, 10561, 27606, 3890, 26682, 4004, 2330, 17, 3253, 21395, 1966, 1925, 22481, 1942, 1920, 5077, 2251, 3423, 2311, 18, 2276, 4114, 3]}, "items": [{"id": "p_2204", "content": "Propranolol [SEP] A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; A", "score": 1, "type": null, "tokenized_content": [2, 21395, 3, 43, 5673, 2251, 2447, 17, 21129, 4127, 25419, 2185, 4666, 17, 13672, 8151, 18, 21395, 2258, 2252, 2251, 1958, 6497, 8358, 31, 18346, 31, 43, 3]}]}
{"query": {"id": "q_2205", "content": "parkinsonian [SEP] ant 40% improvement in the dyskinesia score without increase of parkinsonian motor disability. Ballistic and choreic dyskinesia were markedl", "tokenized_content": [2, 10124, 3122, 3, 4942, 3040, 9, 4990, 1922, 1920, 3890, 26682, 3593, 2979, 2760, 1927, 10124, 3122, 4842, 8015, 18, 9386, 4036, 1930, 11418, 14209, 1030, 3890, 26682, 1985, 4961, 3]}, "items": [{"id": "p_2205", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2206", "content": "motor disability [SEP] vement in the dyskinesia score without increase of parkinsonian motor disability. Ballistic and choreic dyskinesia were markedly ameliorated, wh", "tokenized_content": [2, 4842, 8015, 3, 27706, 1939, 1922, 1920, 3890, 26682, 3593, 2979, 2760, 1927, 10124, 3122, 4842, 8015, 18, 9386, 4036, 1930, 11418, 14209, 1030, 3890, 26682, 1985, 7686, 22085, 16, 3]}, "items": [{"id": "p_2206", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_2207", "content": "dystonia [SEP] istic and choreic dyskinesia were markedly ameliorated, whereas dystonia was not. This study suggests that administration of low doses o", "tokenized_content": [2, 23357, 3, 1977, 2002, 1930, 11418, 14209, 1030, 3890, 26682, 1985, 7686, 22085, 16, 3417, 23357, 1982, 2084, 18, 2052, 2161, 4015, 1988, 4183, 1927, 2330, 5312, 57, 3]}, "items": [{"id": "p_2207", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_2208", "content": "levodopa [SEP] s that administration of low doses of beta-blockers may improve levodopa-induced ballistic and choreic dyskinesia in PD.", "tokenized_content": [2, 26723, 3, 61, 1988, 4183, 1927, 2330, 5312, 1927, 4666, 17, 13628, 2278, 3326, 26723, 17, 2719, 9386, 4036, 1930, 11418, 14209, 1030, 3890, 26682, 1922, 3203, 18, 3]}, "items": [{"id": "p_2208", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_2209", "content": "encephalopathy [SEP] Morphological features of encephalopathy after chronic administration of the antiepileptic drug valproat", "tokenized_content": [2, 19393, 3, 7060, 4075, 1927, 19393, 2256, 3724, 4183, 1927, 1920, 29132, 2838, 23867, 1926, 3]}, "items": [{"id": "p_2209", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_2210", "content": "valproate [SEP] alopathy after chronic administration of the antiepileptic drug valproate to rats. A transmission electron microscopic study of capillari", "tokenized_content": [2, 23867, 2010, 3, 28485, 15935, 2256, 3724, 4183, 1927, 1920, 29132, 2838, 23867, 2010, 1942, 3615, 18, 43, 5303, 4995, 10372, 2161, 1927, 16139, 2205, 3]}, "items": [{"id": "p_2210", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_2211", "content": "sodium valproate [SEP] Long-term intragastric application of the antiepileptic drug sodium valproate (Vupral \"Polfa\") at the effective dose of 200 mg/kg b. w. once ", "tokenized_content": [2, 5227, 23867, 2010, 3, 2815, 17, 2576, 27911, 18318, 4722, 1927, 1920, 29132, 2838, 5227, 23867, 2010, 12, 28193, 13399, 1024, 6, 2492, 6016, 6, 13, 2019, 1920, 3655, 3253, 3]}, "items": [{"id": "p_2211", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_2212", "content": "neurological disorders [SEP]  b. w. once daily to rats for 1, 3, 6, 9 and 12 months revealed neurological disorders indicating cerebellum damage (\"valproate encephalopathy\"). The ", "tokenized_content": [2, 7605, 4414, 3, 44, 18, 65, 18, 5361, 4692, 1942, 3615, 1958, 21, 16, 23, 16, 26, 16, 29, 1930, 2369, 3221, 3404, 7605, 4414, 4168, 12079, 4293, 12, 6, 3]}, "items": [{"id": "p_2212", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2213", "content": "cerebellum damage [SEP] , 6, 9 and 12 months revealed neurological disorders indicating cerebellum damage (\"valproate encephalopathy\"). The first ultrastructural changes", "tokenized_content": [2, 12079, 4293, 3, 16, 26, 16, 29, 1930, 2369, 3221, 3404, 7605, 4414, 4168, 12079, 4293, 12, 6, 23867, 2010, 19393, 6, 13, 18, 1920, 2561, 19352, 2840, 3]}, "items": [{"id": "p_2213", "content": "Cerebellar Diseases [SEP] Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysm", "score": 1, "type": null, "tokenized_content": [2, 11459, 3902, 3, 3902, 1988, 4081, 1920, 3170, 2014, 2347, 1927, 1920, 12079, 18, 27529, 10952, 1927, 11459, 5273, 3951, 26906, 3]}]}
{"query": {"id": "q_2214", "content": "valproate [SEP] -term intragastric application of the antiepileptic drug sodium valproate (Vupral \"Polfa\") at the effective dose of 200 mg/kg b. w. once ", "tokenized_content": [2, 23867, 2010, 3, 17, 2576, 27911, 18318, 4722, 1927, 1920, 29132, 2838, 5227, 23867, 2010, 12, 28193, 13399, 1024, 6, 2492, 6016, 6, 13, 2019, 1920, 3655, 3253, 1927, 2191, 3]}, "items": [{"id": "p_2214", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_2215", "content": "encephalopathy [SEP] neurological disorders indicating cerebellum damage (\"valproate encephalopathy\"). The first ultrastructural changes in structural elements of ", "tokenized_content": [2, 19393, 3, 7605, 4414, 4168, 12079, 4293, 12, 6, 23867, 2010, 19393, 6, 13, 18, 1920, 2561, 19352, 2840, 1922, 4346, 5362, 1927, 3]}, "items": [{"id": "p_2215", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_2216", "content": "necrosis [SEP] yer of the cerebellar cortex. Lesions of the capillary included necrosis of endothelial cells. Organelles of these cells, in particular ", "tokenized_content": [2, 7476, 3, 5293, 1005, 1927, 1920, 11459, 4997, 18, 4518, 1927, 1920, 9623, 3063, 7476, 1927, 5003, 2094, 18, 14487, 1927, 2144, 2094, 16, 1922, 3278, 3]}, "items": [{"id": "p_2216", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_2217", "content": "luminal [SEP] nd occlusion were caused by swollen endothelial cells which had luminal protrusions and swollen microvilli. Pressure on the vessel wall", "tokenized_content": [2, 11776, 3, 8026, 10543, 1985, 4189, 2007, 23561, 5003, 2094, 2154, 2430, 11776, 23383, 1930, 23561, 14264, 13382, 18, 3772, 1990, 1920, 8072, 4821, 3]}, "items": [{"id": "p_2217", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_2218", "content": "necrotic [SEP] ced by enlarged perivascular astrocytic processes. Fragments of necrotic endothelial cells were in the vascular lumens and in these ther", "tokenized_content": [2, 14275, 3, 19424, 2007, 13799, 19946, 22268, 4028, 18, 6535, 1927, 14275, 5003, 2094, 1985, 1922, 1920, 4541, 11223, 1036, 1930, 1922, 2144, 2704, 3]}, "items": [{"id": "p_2218", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_2219", "content": "hepatic damage [SEP] ellar cortex had similar lesions. The possible influence of the hepatic damage, mainly hyperammonemia, upon the development of valproate encep", "tokenized_content": [2, 6095, 4293, 3, 20430, 1933, 4997, 2430, 2551, 4518, 18, 1920, 3216, 4039, 1927, 1920, 6095, 4293, 16, 4994, 4194, 2595, 2290, 6026, 16, 4073, 1920, 2740, 1927, 23867, 2010, 3]}, "items": [{"id": "p_2219", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2220", "content": "hyperammonemia [SEP] r lesions. The possible influence of the hepatic damage, mainly hyperammonemia, upon the development of valproate encephalopathy is discussed.", "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 60, 4518, 18, 1920, 3216, 4039, 1927, 1920, 6095, 4293, 16, 4994, 4194, 2595, 2290, 6026, 16, 4073, 1920, 2740, 1927, 23867, 2010, 19393, 1977, 3]}, "items": [{"id": "p_2220", "content": "Hyperammonemia [SEP] Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 4664, 2237, 1927, 14880, 1922, 1920, 2877, 18, 2176, 1977, 43, 2105, 1927, 9785, 19480, 1927, 3835, 4576, 2014, 14880, 1942, 10505, 18, 3]}]}
{"query": {"id": "q_2221", "content": "toxicity [SEP] Macula toxicity after intravitreal amikacin.", "tokenized_content": [2, 5532, 3, 30265, 5532, 2256, 23580, 15665, 7640, 3665, 18, 3]}, "items": [{"id": "p_2221", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2222", "content": "amikacin [SEP] Macula toxicity after intravitreal amikacin.", "tokenized_content": [2, 15665, 7640, 3665, 3, 30265, 5532, 2256, 23580, 15665, 7640, 3665, 18, 3]}, "items": [{"id": "p_2222", "content": "Amikacin [SEP] A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15665, 7640, 3665, 3, 43, 4949, 17, 5648, 7267, 3595, 2037, 19404, 18, 2176, 1977, 3866, 1037, 17, 1930, 7608, 1037, 17, 6161, 3189, 1920, 2303, 23029, 8028, 7560, 18, 3]}]}
{"query": {"id": "q_2223", "content": "aminoglycosides [SEP] BACKGROUND: Although intravitreal aminoglycosides have substantially improved visual prognosis in endophthalmitis", "tokenized_content": [2, 23029, 17079, 3, 3872, 30, 2876, 23580, 23029, 17079, 2162, 7878, 4305, 3737, 6573, 1922, 19771, 27980, 3678, 3]}, "items": [{"id": "p_2223", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_2224", "content": "endophthalmitis [SEP] aminoglycosides have substantially improved visual prognosis in endophthalmitis, macular infarction may impair full visual recovery. METHODS: W", "tokenized_content": [2, 19771, 27980, 3678, 3, 23029, 17079, 2162, 7878, 4305, 3737, 6573, 1922, 19771, 27980, 3678, 16, 14453, 8358, 2278, 3960, 4125, 3737, 5241, 18, 2860, 30, 65, 3]}, "items": [{"id": "p_2224", "content": "Endophthalmitis [SEP] Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19771, 27980, 3678, 3, 17528, 9280, 2185, 4531, 1927, 1920, 3878, 1927, 1920, 4495, 4061, 1927, 1920, 5723, 5467, 2458, 1956, 1925, 2909, 18, 3]}]}
{"query": {"id": "q_2225", "content": "infarction [SEP] tantially improved visual prognosis in endophthalmitis, macular infarction may impair full visual recovery. METHODS: We present a case of ", "tokenized_content": [2, 8358, 3, 10434, 5093, 4305, 3737, 6573, 1922, 19771, 27980, 3678, 16, 14453, 8358, 2278, 3960, 4125, 3737, 5241, 18, 2860, 30, 2038, 2481, 43, 3087, 1927, 3]}, "items": [{"id": "p_2225", "content": "Infarction [SEP] Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most", "score": 1, "type": null, "tokenized_content": [2, 8358, 3, 3337, 1927, 1925, 13389, 16, 2154, 1977, 7476, 1922, 2960, 2810, 1942, 3076, 7716, 3864, 2037, 10849, 1927, 2877, 9255, 16, 2501, 3]}]}
{"query": {"id": "q_2226", "content": "amikacin [SEP] ir full visual recovery. METHODS: We present a case of presumed amikacin retinal toxicity following treatment with amikacin and vancomyc", "tokenized_content": [2, 15665, 7640, 3665, 3, 3166, 4125, 3737, 5241, 18, 2860, 30, 2038, 2481, 43, 3087, 1927, 15326, 15665, 7640, 3665, 6943, 5532, 2894, 2311, 1956, 15665, 7640, 3665, 1930, 14372, 3]}, "items": [{"id": "p_2226", "content": "Amikacin [SEP] A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15665, 7640, 3665, 3, 43, 4949, 17, 5648, 7267, 3595, 2037, 19404, 18, 2176, 1977, 3866, 1037, 17, 1930, 7608, 1037, 17, 6161, 3189, 1920, 2303, 23029, 8028, 7560, 18, 3]}]}
{"query": {"id": "q_2227", "content": "retinal toxicity [SEP] isual recovery. METHODS: We present a case of presumed amikacin retinal toxicity following treatment with amikacin and vancomycin for alpha-haem", "tokenized_content": [2, 6943, 5532, 3, 1977, 2224, 5241, 18, 2860, 30, 2038, 2481, 43, 3087, 1927, 15326, 15665, 7640, 3665, 6943, 5532, 2894, 2311, 1956, 15665, 7640, 3665, 1930, 16100, 1958, 4595, 3]}, "items": [{"id": "p_2227", "content": "Retinal Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6943, 3902, 3, 3]}]}
{"query": {"id": "q_2228", "content": "vancomycin [SEP] amikacin retinal toxicity following treatment with amikacin and vancomycin for alpha-haemolytic streptococcal endophthalmitis. RESULTS: En", "tokenized_content": [2, 16100, 3, 15665, 7640, 3665, 6943, 5532, 2894, 2311, 1956, 15665, 7640, 3665, 1930, 16100, 1958, 4595, 17, 7105, 6586, 8987, 11748, 19771, 27980, 3678, 18, 2274, 30, 2066, 3]}, "items": [{"id": "p_2228", "content": "Vancomycin [SEP] Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wal", "score": 1, "type": null, "tokenized_content": [2, 16100, 3, 13021, 2926, 2037, 22874, 5567, 19337, 18, 2176, 1977, 43, 8821, 8253, 2712, 1942, 2511, 4575, 15753, 1988, 7042, 4543, 2024, 16567, 3]}]}
{"query": {"id": "q_2229", "content": "streptococcal endophthalmitis [SEP] ing treatment with amikacin and vancomycin for alpha-haemolytic streptococcal endophthalmitis. RESULTS: Endophthalmitis resolved with improvement in visual a", "tokenized_content": [2, 8987, 11748, 19771, 27980, 3678, 3, 30393, 2311, 1956, 15665, 7640, 3665, 1930, 16100, 1958, 4595, 17, 7105, 6586, 8987, 11748, 19771, 27980, 3678, 18, 2274, 30, 19771, 27980, 3678, 3]}, "items": [{"id": "p_2229", "content": "Streptococcal Infections [SEP] Infections with bacteria of the genus STREPTOCOCCUS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8987, 11748, 5024, 3, 5024, 1956, 4802, 1927, 1920, 9487, 15746, 18, 3]}]}
{"query": {"id": "q_2230", "content": "Endophthalmitis [SEP] in for alpha-haemolytic streptococcal endophthalmitis. RESULTS: Endophthalmitis resolved with improvement in visual acuity to 6/24 at three mon", "tokenized_content": [2, 19771, 27980, 3678, 3, 1922, 1958, 4595, 17, 7105, 6586, 8987, 11748, 19771, 27980, 3678, 18, 2274, 30, 19771, 27980, 3678, 8397, 1956, 4990, 1922, 3737, 12320, 1942, 26, 19, 3]}, "items": [{"id": "p_2230", "content": "Endophthalmitis [SEP] Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19771, 27980, 3678, 3, 17528, 9280, 2185, 4531, 1927, 1920, 3878, 1927, 1920, 4495, 4061, 1927, 1920, 5723, 5467, 2458, 1956, 1925, 2909, 18, 3]}]}
{"query": {"id": "q_2231", "content": "fluorescein [SEP] th improvement in visual acuity to 6/24 at three months. Fundus fluorescein angiography confirmed macular capillary closure and telangiecta", "tokenized_content": [2, 14167, 3, 1913, 4990, 1922, 3737, 12320, 1942, 26, 19, 2686, 2019, 2559, 3221, 18, 18862, 14167, 11676, 3982, 14453, 9623, 10408, 1930, 30512, 1019, 3]}, "items": [{"id": "p_2231", "content": "Fluorescein [SEP] A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aq", "score": 1, "type": null, "tokenized_content": [2, 14167, 3, 43, 19686, 1935, 8413, 8347, 1988, 5107, 7463, 17, 4524, 1922, 2791, 12650, 8030, 1930, 10944, 4524, 1922, 43, 2253, 10746, 3649, 2427, 1966, 1920, 11331, 3]}]}
{"query": {"id": "q_2232", "content": "telangiectasis [SEP] fluorescein angiography confirmed macular capillary closure and telangiectasis. CONCLUSIONS: Currently accepted intravitreal antibiotic regime", "tokenized_content": [2, 30512, 3932, 3, 14167, 11676, 3982, 14453, 9623, 10408, 1930, 30512, 3932, 18, 4355, 30, 5077, 8131, 23580, 7267, 13737, 3]}, "items": [{"id": "p_2232", "content": "Telangiectasis [SEP] Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most common", "score": 1, "type": null, "tokenized_content": [2, 30512, 3932, 3, 11047, 16470, 1927, 21604, 2877, 7208, 12, 16973, 31, 24332, 31, 8102, 3275, 13, 11124, 2858, 8083, 2312, 4518, 16, 2501, 3059, 3]}]}
{"query": {"id": "q_2233", "content": "ischaemia [SEP] real antibiotic regimens may cause retinal toxicity and macular ischaemia. Treatment strategies aimed at avoiding retinal toxicity are di", "tokenized_content": [2, 22927, 3, 4105, 7267, 9922, 2278, 3936, 6943, 5532, 1930, 14453, 22927, 18, 2311, 4762, 6822, 2019, 13910, 6943, 5532, 2032, 2137, 3]}, "items": [{"id": "p_2233", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_2234", "content": "atrioventricular reentrant tachycardia [SEP] Iatrogenically induced intractable atrioventricular reentrant tachycardia after verapamil and catheter ablation in a patient with Wolff-P", "tokenized_content": [2, 28355, 21747, 4905, 17182, 1031, 17397, 3, 26674, 2169, 2719, 26032, 28355, 21747, 4905, 17182, 1031, 17397, 2256, 23300, 1930, 8421, 9413, 1922, 43, 2774, 1956, 25254, 1038, 17, 58, 3]}, "items": [{"id": "p_2234", "content": "Tachycardia, Atrioventricular Nodal Reentry [SEP] Abnormally rapid heartbeats caused by reentry of atrial impulse into the dual (fast and slow) pathways of ATRIOVENTRICULAR NODE.", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 28355, 13926, 21747, 4905, 6907, 3, 20756, 4052, 4003, 5873, 5149, 4189, 2007, 21747, 4905, 6907, 1927, 9224, 21896, 2460, 1920, 7064, 12, 5867, 1930, 5470, 13, 3873, 1927, 28355, 6267, 18, 3]}]}
{"query": {"id": "q_2235", "content": "verapamil [SEP] nduced intractable atrioventricular reentrant tachycardia after verapamil and catheter ablation in a patient with Wolff-Parkinson-White s", "tokenized_content": [2, 23300, 3, 8026, 2418, 26032, 28355, 21747, 4905, 17182, 1031, 17397, 2256, 23300, 1930, 8421, 9413, 1922, 43, 2774, 1956, 25254, 1038, 17, 10124, 17, 4511, 61, 3]}, "items": [{"id": "p_2235", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_2236", "content": "Wolff-Parkinson-White syndrome [SEP] ycardia after verapamil and catheter ablation in a patient with Wolff-Parkinson-White syndrome and idiopathic dilated cardiomyopathy.", "tokenized_content": [2, 25254, 1038, 17, 10124, 17, 4511, 4741, 3, 22386, 13047, 2256, 23300, 1930, 8421, 9413, 1922, 43, 2774, 1956, 25254, 1038, 17, 10124, 17, 4511, 4741, 1930, 13513, 16434, 14141, 3]}, "items": [{"id": "p_2236", "content": "Wolff-Parkinson-White Syndrome [SEP] A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syn", "score": 1, "type": null, "tokenized_content": [2, 25254, 1038, 17, 10124, 17, 4511, 4741, 3, 43, 2386, 1927, 6493, 2097, 17, 8392, 4378, 2007, 43, 3662, 2033, 4979, 1930, 43, 2815, 22355, 4979, 1956, 43, 9649, 5913, 18, 1922, 2052, 2540, 3]}]}
{"query": {"id": "q_2237", "content": "idiopathic dilated cardiomyopathy [SEP] r ablation in a patient with Wolff-Parkinson-White syndrome and idiopathic dilated cardiomyopathy.", "tokenized_content": [2, 13513, 16434, 14141, 3, 60, 9413, 1922, 43, 2774, 1956, 25254, 1038, 17, 10124, 17, 4511, 4741, 1930, 13513, 16434, 14141, 18, 3]}, "items": [{"id": "p_2237", "content": "Cardiomyopathy, Dilated [SEP] A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 16434, 3, 43, 2386, 1927, 4435, 3760, 2573, 1988, 1977, 4378, 2007, 6493, 16470, 16, 6493, 5273, 16, 1930, 4003, 4574, 18, 2565, 3]}]}
{"query": {"id": "q_2238", "content": "WPW syndrome [SEP] In a patient with WPW syndrome and idiopathic dilated cardiomyopathy, intractable atrioventric", "tokenized_content": [2, 21459, 1018, 4741, 3, 1922, 43, 2774, 1956, 21459, 1018, 4741, 1930, 13513, 16434, 14141, 16, 26032, 26500, 24439, 3319, 3]}, "items": [{"id": "p_2238", "content": "Wolff-Parkinson-White Syndrome [SEP] A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syn", "score": 1, "type": null, "tokenized_content": [2, 25254, 1038, 17, 10124, 17, 4511, 4741, 3, 43, 2386, 1927, 6493, 2097, 17, 8392, 4378, 2007, 43, 3662, 2033, 4979, 1930, 43, 2815, 22355, 4979, 1956, 43, 9649, 5913, 18, 1922, 2052, 2540, 3]}]}
{"query": {"id": "q_2239", "content": "idiopathic dilated cardiomyopathy [SEP] In a patient with WPW syndrome and idiopathic dilated cardiomyopathy, intractable atrioventricular reentrant tachycardia (AVRT) was ", "tokenized_content": [2, 13513, 16434, 14141, 3, 1922, 43, 2774, 1956, 21459, 1018, 4741, 1930, 13513, 16434, 14141, 16, 26032, 28355, 21747, 4905, 17182, 1031, 17397, 12, 22867, 1031, 13, 1982, 3]}, "items": [{"id": "p_2239", "content": "Cardiomyopathy, Dilated [SEP] A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 16434, 3, 43, 2386, 1927, 4435, 3760, 2573, 1988, 1977, 4378, 2007, 6493, 16470, 16, 6493, 5273, 16, 1930, 4003, 4574, 18, 2565, 3]}]}
{"query": {"id": "q_2240", "content": "atrioventricular reentrant tachycardia [SEP] WPW syndrome and idiopathic dilated cardiomyopathy, intractable atrioventricular reentrant tachycardia (AVRT) was iatrogenically induced. QRS without preexcitation, c", "tokenized_content": [2, 28355, 21747, 4905, 17182, 1031, 17397, 3, 21459, 1018, 4741, 1930, 13513, 16434, 14141, 16, 26032, 28355, 21747, 4905, 17182, 1031, 17397, 12, 22867, 1031, 13, 1982, 26674, 2169, 2719, 3]}, "items": [{"id": "p_2240", "content": "Tachycardia, Atrioventricular Nodal Reentry [SEP] Abnormally rapid heartbeats caused by reentry of atrial impulse into the dual (fast and slow) pathways of ATRIOVENTRICULAR NODE.", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 28355, 13926, 21747, 4905, 6907, 3, 20756, 4052, 4003, 5873, 5149, 4189, 2007, 21747, 4905, 6907, 1927, 9224, 21896, 2460, 1920, 7064, 12, 5867, 1930, 5470, 13, 3873, 1927, 28355, 6267, 18, 3]}]}
{"query": {"id": "q_2241", "content": "AVRT [SEP] iomyopathy, intractable atrioventricular reentrant tachycardia (AVRT) was iatrogenically induced. QRS without preexcitation, caused ", "tokenized_content": [2, 22867, 1031, 3, 21509, 14930, 6522, 16, 26032, 28355, 21747, 4905, 17182, 1031, 17397, 12, 22867, 1031, 13, 1982, 26674, 2169, 2719, 18, 22355, 2979, 19254, 3349, 4926, 16, 4189, 3]}, "items": [{"id": "p_2241", "content": "Tachycardia, Atrioventricular Nodal Reentry [SEP] Abnormally rapid heartbeats caused by reentry of atrial impulse into the dual (fast and slow) pathways of ATRIOVENTRICULAR NODE.", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 28355, 13926, 21747, 4905, 6907, 3, 20756, 4052, 4003, 5873, 5149, 4189, 2007, 21747, 4905, 6907, 1927, 9224, 21896, 2460, 1920, 7064, 12, 5867, 1930, 5470, 13, 3873, 1927, 28355, 6267, 18, 3]}]}
{"query": {"id": "q_2242", "content": "verapamil [SEP]  without preexcitation, caused by junctional escape beats after verapamil or unidirectional antegrade block of accessory pathway after ca", "tokenized_content": [2, 23300, 3, 2979, 19254, 3349, 4926, 16, 4189, 2007, 21226, 11781, 19380, 2256, 23300, 2014, 28250, 27871, 10684, 3367, 1927, 15954, 3374, 2256, 2332, 3]}, "items": [{"id": "p_2242", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_2243", "content": "liver disease [SEP] Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substi", "tokenized_content": [2, 3568, 2573, 3, 12107, 1927, 3568, 2573, 4189, 2007, 14369, 4199, 11525, 22780, 2101, 2251, 1966, 19184, 17, 17981, 5879, 1033, 3]}, "items": [{"id": "p_2243", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2244", "content": "ozone [SEP] mic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons.", "tokenized_content": [2, 19184, 3, 2206, 1927, 3568, 2573, 4189, 2007, 14369, 4199, 11525, 22780, 2101, 2251, 1966, 19184, 17, 17981, 18336, 1036, 1927, 10107, 14592, 22780, 2101, 18, 3]}, "items": [{"id": "p_2244", "content": "Ozone [SEP] The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. I", "score": 1, "type": null, "tokenized_content": [2, 19184, 3, 1920, 11976, 5083, 8286, 4913, 2386, 1927, 4612, 16, 20617, 18, 2176, 1977, 43, 9974, 16138, 1988, 1977, 4152, 1958, 3425, 4399, 1930, 11181, 7947, 18, 51, 3]}]}
{"query": {"id": "q_2245", "content": "chlorofluorocarbons [SEP] Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons.", "tokenized_content": [2, 10107, 14592, 22780, 2101, 3, 12107, 1927, 3568, 2573, 4189, 2007, 14369, 4199, 11525, 22780, 2101, 2251, 1966, 19184, 17, 17981, 18336, 1036, 1927, 10107, 14592, 22780, 2101, 18, 3]}, "items": [{"id": "p_2245", "content": "Chlorofluorocarbons [SEP] A series of hydrocarbons containing both chlorine and fluorine. These have been used as refrigerants, blowing agents, cleaning f", "score": 1, "type": null, "tokenized_content": [2, 10107, 14592, 22780, 2101, 3, 43, 4696, 1927, 22318, 3165, 2321, 25732, 1930, 29700, 18, 2144, 2162, 2252, 2251, 1966, 27484, 2356, 16, 16635, 17860, 1029, 4820, 16, 17833, 48, 3]}]}
{"query": {"id": "q_2246", "content": "ozone [SEP] ns (HCFCs) are used increasingly in industry as substitutes for ozone-depleting chlorofluorocarbons (CFCs). Limited studies in animal", "tokenized_content": [2, 19184, 3, 4246, 12, 4387, 8815, 1036, 13, 2032, 2251, 8827, 1922, 10342, 1966, 18336, 1036, 1958, 19184, 17, 27937, 10107, 14592, 22780, 2101, 12, 4920, 2792, 13, 18, 3892, 3]}, "items": [{"id": "p_2246", "content": "Ozone [SEP] The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. I", "score": 1, "type": null, "tokenized_content": [2, 19184, 3, 1920, 11976, 5083, 8286, 4913, 2386, 1927, 4612, 16, 20617, 18, 2176, 1977, 43, 9974, 16138, 1988, 1977, 4152, 1958, 3425, 4399, 1930, 11181, 7947, 18, 51, 3]}]}
{"query": {"id": "q_2247", "content": "chlorofluorocarbons [SEP] BACKGROUND: Hydrochlorofluorocarbons (HCFCs) are used increasingly in industry as substitutes for oz", "tokenized_content": [2, 10107, 14592, 22780, 2101, 3, 3872, 30, 14369, 4199, 11525, 22780, 2101, 12, 4387, 8815, 1036, 13, 2032, 2251, 8827, 1922, 10342, 1966, 18336, 1036, 1958, 13888, 3]}, "items": [{"id": "p_2247", "content": "Chlorofluorocarbons [SEP] A series of hydrocarbons containing both chlorine and fluorine. These have been used as refrigerants, blowing agents, cleaning f", "score": 1, "type": null, "tokenized_content": [2, 10107, 14592, 22780, 2101, 3, 43, 4696, 1927, 22318, 3165, 2321, 25732, 1930, 29700, 18, 2144, 2162, 2252, 2251, 1966, 27484, 2356, 16, 16635, 17860, 1029, 4820, 16, 17833, 48, 3]}]}
{"query": {"id": "q_2248", "content": "CFCs [SEP] BACKGROUND: Hydrochlorofluorocarbons (HCFCs) are used increasingly in industry as substitutes for ozone-dep", "tokenized_content": [2, 4920, 2792, 3, 3872, 30, 14369, 4199, 11525, 22780, 2101, 12, 4387, 8815, 1036, 13, 2032, 2251, 8827, 1922, 10342, 1966, 18336, 1036, 1958, 19184, 17, 2554, 3]}, "items": [{"id": "p_2248", "content": "Chlorofluorocarbons [SEP] A series of hydrocarbons containing both chlorine and fluorine. These have been used as refrigerants, blowing agents, cleaning f", "score": 1, "type": null, "tokenized_content": [2, 10107, 14592, 22780, 2101, 3, 43, 4696, 1927, 22318, 3165, 2321, 25732, 1930, 29700, 18, 2144, 2162, 2252, 2251, 1966, 27484, 2356, 16, 16635, 17860, 1029, 4820, 16, 17833, 48, 3]}]}
{"query": {"id": "q_2249", "content": "hepatotoxicity [SEP] rocarbons (CFCs). Limited studies in animals indicate potential hepatotoxicity of some of these compounds. We investigated an epidemic of live", "tokenized_content": [2, 24126, 3, 10326, 6299, 2101, 12, 4920, 2792, 13, 18, 3892, 2351, 1922, 3555, 3579, 2889, 24126, 1927, 2673, 1927, 2144, 4300, 18, 2038, 3845, 1925, 12107, 1927, 6922, 3]}, "items": [{"id": "p_2249", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2250", "content": "liver disease [SEP] city of some of these compounds. We investigated an epidemic of liver disease in nine industrial workers who had had repeated accidental expo", "tokenized_content": [2, 3568, 2573, 3, 8318, 1927, 2673, 1927, 2144, 4300, 18, 2038, 3845, 1925, 12107, 1927, 3568, 2573, 1922, 6360, 11181, 7066, 2746, 2430, 2430, 5116, 24842, 2887, 1037, 3]}, "items": [{"id": "p_2250", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2251", "content": "1,1-dichloro-2,2,2-trifluoroethane [SEP] orkers who had had repeated accidental exposure to a mixture of 1,1-dichloro-2,2,2-trifluoroethane (HCFC 123) and 1-chloro-1,2,2,2-tetrafluoroethane (HCFC 124). A", "tokenized_content": [2, 21, 16, 21, 17, 29105, 17, 22, 16, 22, 16, 22, 17, 18560, 6802, 1963, 2516, 3, 2014, 13548, 1036, 2746, 2430, 2430, 5116, 24842, 3395, 1942, 43, 5515, 1927, 3]}, "items": [{"id": "p_2251", "content": "2,2-dichloro-1,1,1-trifluoroethane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 16, 22, 17, 29105, 17, 21, 16, 21, 16, 21, 17, 18560, 6802, 1963, 2516, 3, 3]}]}
{"query": {"id": "q_2252", "content": "HCFC 123 [SEP] al exposure to a mixture of 1,1-dichloro-2,2,2-trifluoroethane (HCFC 123) and 1-chloro-1,2,2,2-tetrafluoroethane (HCFC 124). All nine ex", "tokenized_content": [2, 4387, 8815, 10900, 3, 1969, 3395, 1942, 43, 5515, 1927, 21, 16, 21, 17, 29105, 17, 22, 16, 22, 16, 22, 17, 18560, 6802, 1963, 2516, 12, 4387, 8815, 10900, 3]}, "items": [{"id": "p_2252", "content": "2,2-dichloro-1,1,1-trifluoroethane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 16, 22, 17, 29105, 17, 21, 16, 21, 16, 21, 17, 18560, 6802, 1963, 2516, 3, 3]}]}
{"query": {"id": "q_2253", "content": "1-chloro-1,2,2,2-tetrafluoroethane [SEP]  a mixture of 1,1-dichloro-2,2,2-trifluoroethane (HCFC 123) and 1-chloro-1,2,2,2-tetrafluoroethane (HCFC 124). All nine exposed workers were affected to various d", "tokenized_content": [2, 21, 17, 10107, 17, 21, 16, 22, 16, 22, 16, 22, 17, 12470, 14592, 6802, 1963, 2516, 3, 43, 5515, 1927, 21, 16, 21, 17, 29105, 17, 22, 16, 22, 3]}, "items": [{"id": "p_2253", "content": "1,1,1,2-tetrafluoro-2-chloroethane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 16, 21, 16, 21, 16, 22, 17, 12470, 14592, 1037, 17, 22, 17, 10107, 3184, 2516, 3, 3]}]}
{"query": {"id": "q_2254", "content": "HCFC 124 [SEP] fluoroethane (HCFC 123) and 1-chloro-1,2,2,2-tetrafluoroethane (HCFC 124). All nine exposed workers were affected to various degrees. Bo", "tokenized_content": [2, 4387, 8815, 10955, 3, 16191, 3184, 2516, 12, 4387, 8815, 10900, 13, 1930, 21, 17, 10107, 17, 21, 16, 22, 16, 22, 16, 22, 17, 12470, 14592, 6802, 1963, 2516, 3]}, "items": [{"id": "p_2254", "content": "1,1,1,2-tetrafluoro-2-chloroethane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 16, 21, 16, 21, 16, 22, 17, 12470, 14592, 1037, 17, 22, 17, 10107, 3184, 2516, 3, 3]}]}
{"query": {"id": "q_2255", "content": "1-bromo-1-chloro-2,2,2-trifluoroethane [SEP] ious degrees. Both compounds are metabolised in the same way as 1-bromo-1-chloro-2,2,2-trifluoroethane (halothane) to form reactive trifluoroacetyl halide intermediat", "tokenized_content": [2, 21, 17, 21392, 17, 21, 17, 10107, 17, 22, 16, 22, 16, 22, 17, 18560, 6802, 1963, 2516, 3, 21509, 1957, 6429, 18, 2321, 4300, 2032, 3074, 3495, 1922, 1920, 3]}, "items": [{"id": "p_2255", "content": "Halothane [SEP] A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analg", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 3, 43, 19136, 10082, 3368, 7272, 16, 24778, 1981, 16, 21638, 16111, 1988, 4558, 4322, 4052, 4408, 1956, 5082, 2014, 2239, 7817, 2855, 18, 2151, 1029, 3]}]}
{"query": {"id": "q_2256", "content": "halothane [SEP] ised in the same way as 1-bromo-1-chloro-2,2,2-trifluoroethane (halothane) to form reactive trifluoroacetyl halide intermediates, which h", "tokenized_content": [2, 23226, 1963, 2516, 3, 1977, 1919, 1922, 1920, 2841, 4222, 1966, 21, 17, 21392, 17, 21, 17, 10107, 17, 22, 16, 22, 16, 22, 17, 18560, 6802, 1963, 2516, 12, 3]}, "items": [{"id": "p_2256", "content": "Halothane [SEP] A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analg", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 3, 43, 19136, 10082, 3368, 7272, 16, 24778, 1981, 16, 21638, 16111, 1988, 4558, 4322, 4052, 4408, 1956, 5082, 2014, 2239, 7817, 2855, 18, 2151, 1029, 3]}]}
{"query": {"id": "q_2257", "content": "trifluoroacetyl [SEP] omo-1-chloro-2,2,2-trifluoroethane (halothane) to form reactive trifluoroacetyl halide intermediates, which have been implicated in the hepatot", "tokenized_content": [2, 18560, 15365, 3152, 1024, 3, 7254, 1037, 17, 21, 17, 10107, 17, 22, 16, 22, 16, 22, 17, 18560, 6802, 1963, 2516, 12, 23226, 1963, 2516, 13, 1942, 2386, 6079, 3]}, "items": [{"id": "p_2257", "content": "Trifluoroacetic Acid [SEP] A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is ", "score": 1, "type": null, "tokenized_content": [2, 18560, 21117, 2687, 3, 43, 3345, 3206, 24778, 1981, 10533, 1927, 13069, 2687, 18, 2176, 1977, 2251, 1922, 2687, 12139, 5298, 16, 4369, 2690, 2597, 1925, 9603, 1977, 3]}]}
{"query": {"id": "q_2258", "content": "HCFCs 123 [SEP] ed in the hepatotoxicity of halothane. We aimed to test whether HCFCs 123 and 124 can result in serious liver disease. METHODS: For one s", "tokenized_content": [2, 4387, 8815, 1036, 10900, 3, 3347, 1922, 1920, 24126, 1927, 23226, 1963, 2516, 18, 2038, 6822, 1942, 2648, 3053, 4387, 8815, 1036, 10900, 1930, 10955, 2112, 3211, 1922, 7433, 3568, 3]}, "items": [{"id": "p_2258", "content": "2,2-dichloro-1,1,1-trifluoroethane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 16, 22, 17, 29105, 17, 21, 16, 21, 16, 21, 17, 18560, 6802, 1963, 2516, 3, 3]}]}
{"query": {"id": "q_2259", "content": "necrosis [SEP]  (P58). FINDINGS: The liver biopsy sample showed hepatocellular necrosis which was prominent in perivenular zone three and extended foca", "tokenized_content": [2, 7476, 3, 12, 18974, 1025, 13, 18, 3056, 30, 1920, 3568, 6831, 2983, 2594, 12457, 7476, 2154, 1982, 8753, 1922, 16505, 1917, 2168, 7441, 2559, 1930, 6091, 3438, 1019, 3]}, "items": [{"id": "p_2259", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_2260", "content": "Trifluoroacetyl [SEP] s to portal tracts and centrilobular areas (bridging necrosis). Trifluoroacetyl-adducted proteins were detected in surviving hepatocytes. Autoa", "tokenized_content": [2, 18560, 15365, 3152, 1024, 3, 61, 1942, 10669, 14810, 1930, 23348, 6012, 17909, 5148, 1005, 3957, 12, 17908, 7476, 13, 18, 18560, 15365, 3152, 1024, 17, 18533, 1919, 2697, 1985, 3]}, "items": [{"id": "p_2260", "content": "Trifluoroacetic Acid [SEP] A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is ", "score": 1, "type": null, "tokenized_content": [2, 18560, 21117, 2687, 3, 43, 3345, 3206, 24778, 1981, 10533, 1927, 13069, 2687, 18, 2176, 1977, 2251, 1922, 2687, 12139, 5298, 16, 4369, 2690, 2597, 1925, 9603, 1977, 3]}]}
{"query": {"id": "q_2261", "content": "halothane hepatitis [SEP] oantibodies against P450 2E1 or P58, previously associated with halothane hepatitis, were detected in the serum of five affected workers. INTERPRET", "tokenized_content": [2, 23226, 1963, 2516, 7977, 3, 8965, 4905, 2023, 3462, 3316, 12088, 11416, 1009, 2014, 18974, 1025, 16, 3024, 2458, 1956, 23226, 1963, 2516, 7977, 16, 1985, 3330, 1922, 1920, 3256, 3]}, "items": [{"id": "p_2261", "content": "Halothane Hepatitis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23226, 1963, 2516, 7977, 3, 3]}]}
{"query": {"id": "q_2262", "content": "liver injury [SEP] sure of human beings to HCFCs 123 and 124 can result in serious liver injury in a large proportion of the exposed population. Although the e", "tokenized_content": [2, 3568, 4047, 3, 16320, 1927, 2616, 30093, 1942, 4387, 8815, 1036, 10900, 1930, 10955, 2112, 3211, 1922, 7433, 3568, 4047, 1922, 43, 3103, 4242, 1927, 1920, 4616, 2973, 18, 2876, 3]}, "items": [{"id": "p_2262", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2263", "content": "hearing loss [SEP] The effect of different anaesthetic agents in hearing loss following spinal anaesthesia.", "tokenized_content": [2, 8512, 3257, 3, 1920, 2495, 1927, 2413, 28818, 4820, 1922, 8512, 3257, 2894, 6071, 17107, 18, 3]}, "items": [{"id": "p_2263", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_2264", "content": "hearing loss [SEP] The cause of hearing loss after spinal anaesthesia is unknown. Up until now, the only fac", "tokenized_content": [2, 8512, 3257, 3, 1920, 3936, 1927, 8512, 3257, 2256, 6071, 17107, 1977, 5435, 18, 2353, 4801, 5195, 16, 1920, 2444, 3186, 3]}, "items": [{"id": "p_2264", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_2265", "content": "sensorineural hearing loss [SEP] e effect of the diameter of the spinal needle on post-operative sensorineural hearing loss. The aim of this study was to describe this hearing loss and to", "tokenized_content": [2, 6443, 2053, 2741, 8512, 3257, 3, 47, 2495, 1927, 1920, 5483, 1927, 1920, 6071, 9351, 1990, 2753, 17, 8116, 6443, 2053, 2741, 8512, 3257, 18, 1920, 3774, 1927, 2052, 2161, 3]}, "items": [{"id": "p_2265", "content": "Hearing Loss, Sensorineural [SEP] Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 6443, 2053, 2741, 3, 8512, 3257, 3864, 2037, 4293, 1942, 1920, 23310, 1930, 1920, 6443, 2053, 2741, 5362, 2154, 14958, 23125, 6844, 1920, 22584, 1930, 7464, 3]}]}
{"query": {"id": "q_2266", "content": "prilocaine [SEP] ps of 22 similar patients were studied: one group received 6 mL prilocaine 2%; and the other received 3 mL bupivacaine 0.5%. Patients give", "tokenized_content": [2, 17618, 6012, 3375, 2053, 3, 2742, 1927, 2950, 2551, 2132, 1985, 3942, 30, 2340, 2210, 4004, 26, 2646, 17618, 6012, 3375, 2053, 22, 9, 31, 1930, 1920, 2303, 4004, 23, 3]}, "items": [{"id": "p_2266", "content": "Prilocaine [SEP] A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia ", "score": 1, "type": null, "tokenized_content": [2, 17618, 6012, 3375, 2053, 3, 43, 3076, 16111, 1988, 1977, 2551, 24645, 1942, 19567, 18, 5077, 16, 2176, 1977, 2251, 2501, 3868, 1958, 8946, 8871, 3]}]}
{"query": {"id": "q_2267", "content": "bupivacaine [SEP]  group received 6 mL prilocaine 2%; and the other received 3 mL bupivacaine 0.5%. Patients given prilocaine were more likely to develop hea", "tokenized_content": [2, 25473, 3, 2210, 4004, 26, 2646, 17618, 6012, 3375, 2053, 22, 9, 31, 1930, 1920, 2303, 4004, 23, 2646, 25473, 20, 18, 25, 9, 18, 2132, 3258, 17618, 6012, 3375, 3]}, "items": [{"id": "p_2267", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_2268", "content": "neurological deficit [SEP] A transient neurological deficit following intrathecal injection of 1% hyperbaric bupivacaine fo", "tokenized_content": [2, 7605, 10506, 3, 43, 6809, 7605, 10506, 2894, 22782, 4107, 1927, 21, 9, 4194, 8751, 1935, 25473, 5917, 3]}, "items": [{"id": "p_2268", "content": "Neurologic Manifestations [SEP] Clinical signs and symptoms caused by nervous system injury or dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14314, 10952, 3, 2535, 6879, 1930, 3601, 4189, 2007, 7580, 2433, 4047, 2014, 5273, 18, 3]}]}
{"query": {"id": "q_2269", "content": "bupivacaine [SEP] ogical deficit following intrathecal injection of 1% hyperbaric bupivacaine for unilateral spinal anaesthesia.", "tokenized_content": [2, 25473, 3, 17395, 2046, 10506, 2894, 22782, 4107, 1927, 21, 9, 4194, 8751, 1935, 25473, 1958, 12059, 6071, 17107, 18, 3]}, "items": [{"id": "p_2269", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_2270", "content": "neurological deficit [SEP] We describe a case of transient neurological deficit that occurred after unilateral spinal anaesthesia with 8 mg of ", "tokenized_content": [2, 7605, 10506, 3, 2038, 5993, 43, 3087, 1927, 6809, 7605, 10506, 1988, 4807, 2256, 12059, 6071, 17107, 1956, 28, 2786, 1927, 3]}, "items": [{"id": "p_2270", "content": "Neurologic Manifestations [SEP] Clinical signs and symptoms caused by nervous system injury or dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14314, 10952, 3, 2535, 6879, 1930, 3601, 4189, 2007, 7580, 2433, 4047, 2014, 5273, 18, 3]}]}
{"query": {"id": "q_2271", "content": "bupivacaine [SEP]  after unilateral spinal anaesthesia with 8 mg of 1% hyperbaric bupivacaine slowly injected through a 25-gauge pencil-point spinal needle. ", "tokenized_content": [2, 25473, 3, 2256, 12059, 6071, 17107, 1956, 28, 2786, 1927, 21, 9, 4194, 8751, 1935, 25473, 11240, 5624, 2596, 43, 2637, 17, 15747, 4959, 10401, 17, 3575, 6071, 9351, 18, 3]}, "items": [{"id": "p_2271", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_2272", "content": "loss of pinprick sensation [SEP] ia over L3-L4 dermatomes of the leg which had been operated on (loss of pinprick sensation) without reduction in muscular strength. Sensation in this area", "tokenized_content": [2, 3257, 1927, 8701, 2047, 3041, 15826, 3, 11640, 2338, 15859, 17, 16546, 13467, 2862, 1927, 1920, 6703, 2154, 2430, 2252, 10497, 1990, 12, 3257, 1927, 8701, 2047, 3041, 15826, 13, 3]}, "items": [{"id": "p_2272", "content": "Sensation Disorders [SEP] Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of ", "score": 1, "type": null, "tokenized_content": [2, 15826, 4414, 3, 4414, 1927, 1920, 5180, 7534, 1036, 12, 51, 18, 47, 18, 16, 9266, 31, 8512, 31, 13891, 31, 1930, 2426, 1992, 13, 2014, 17562, 2433, 12, 51, 18, 47, 18, 16, 15604, 4178, 1927, 3]}]}
{"query": {"id": "q_2273", "content": "Pethidine [SEP] Pethidine-associated seizure in a healthy adolescent receiving pethidine ", "tokenized_content": [2, 5889, 7969, 27099, 3, 5889, 7969, 27099, 17, 2458, 11015, 1922, 43, 4097, 8402, 5962, 5889, 7969, 27099, 3]}, "items": [{"id": "p_2273", "content": "Meperidine [SEP] A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and ", "score": 1, "type": null, "tokenized_content": [2, 17257, 18842, 27099, 3, 43, 22872, 3153, 14501, 1988, 2112, 1998, 2251, 1958, 1920, 13104, 1927, 2501, 3584, 1927, 5086, 1942, 4010, 3594, 16, 2710, 5924, 3594, 1930, 3]}]}
{"query": {"id": "q_2274", "content": "seizure [SEP] Pethidine-associated seizure in a healthy adolescent receiving pethidine for postoperative p", "tokenized_content": [2, 11015, 3, 5889, 7969, 27099, 17, 2458, 11015, 1922, 43, 4097, 8402, 5962, 5889, 7969, 27099, 1958, 5924, 58, 3]}, "items": [{"id": "p_2274", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2275", "content": "pethidine [SEP] Pethidine-associated seizure in a healthy adolescent receiving pethidine for postoperative pain control.", "tokenized_content": [2, 5889, 7969, 27099, 3, 5889, 7969, 27099, 17, 2458, 11015, 1922, 43, 4097, 8402, 5962, 5889, 7969, 27099, 1958, 5924, 3594, 2285, 18, 3]}, "items": [{"id": "p_2275", "content": "Meperidine [SEP] A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and ", "score": 1, "type": null, "tokenized_content": [2, 17257, 18842, 27099, 3, 43, 22872, 3153, 14501, 1988, 2112, 1998, 2251, 1958, 1920, 13104, 1927, 2501, 3584, 1927, 5086, 1942, 4010, 3594, 16, 2710, 5924, 3594, 1930, 3]}]}
{"query": {"id": "q_2276", "content": "postoperative pain [SEP] ociated seizure in a healthy adolescent receiving pethidine for postoperative pain control.", "tokenized_content": [2, 5924, 3594, 3, 5084, 23682, 11015, 1922, 43, 4097, 8402, 5962, 5889, 7969, 27099, 1958, 5924, 3594, 2285, 18, 3]}, "items": [{"id": "p_2276", "content": "Pain, Postoperative [SEP] Pain during the period after surgery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 16, 5924, 3, 3594, 2409, 1920, 3047, 2256, 3782, 18, 3]}]}
{"query": {"id": "q_2277", "content": "pethidine [SEP] ealthy 17-year-old male received standard intermittent doses of pethidine via a patient-controlled analgesia (PCA) pump for management of", "tokenized_content": [2, 5889, 7969, 27099, 3, 11377, 19174, 30338, 2752, 17, 2476, 17, 4156, 4005, 4004, 2970, 13252, 5312, 1927, 5889, 7969, 27099, 3454, 43, 2774, 17, 4642, 14695, 12, 8192, 13, 3]}, "items": [{"id": "p_2277", "content": "Meperidine [SEP] A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and ", "score": 1, "type": null, "tokenized_content": [2, 17257, 18842, 27099, 3, 43, 22872, 3153, 14501, 1988, 2112, 1998, 2251, 1958, 1920, 13104, 1927, 2501, 3584, 1927, 5086, 1942, 4010, 3594, 16, 2710, 5924, 3594, 1930, 3]}]}
{"query": {"id": "q_2278", "content": "postoperative pain [SEP] via a patient-controlled analgesia (PCA) pump for management of postoperative pain control. Twenty-three h postoperatively he developed a brief se", "tokenized_content": [2, 5924, 3594, 3, 3454, 43, 2774, 17, 4642, 14695, 12, 8192, 13, 8912, 1958, 4280, 1927, 5924, 3594, 2285, 18, 7639, 17, 2559, 50, 13173, 2234, 3530, 43, 5310, 2058, 3]}, "items": [{"id": "p_2278", "content": "Pain, Postoperative [SEP] Pain during the period after surgery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 16, 5924, 3, 3594, 2409, 1920, 3047, 2256, 3782, 18, 3]}]}
{"query": {"id": "q_2279", "content": "seizure [SEP] wenty-three h postoperatively he developed a brief self-limited seizure. Both plasma pethidine and norpethidine were elevated in the ra", "tokenized_content": [2, 11015, 3, 16533, 1012, 17, 2559, 50, 13173, 2234, 3530, 43, 5310, 3543, 17, 3892, 11015, 18, 2321, 3582, 5889, 7969, 27099, 1930, 3990, 9626, 22523, 27099, 1985, 4664, 1922, 3]}, "items": [{"id": "p_2279", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2280", "content": "norpethidine [SEP] veloped a brief self-limited seizure. Both plasma pethidine and norpethidine were elevated in the range associated with clinical manifestati", "tokenized_content": [2, 3990, 9626, 22523, 27099, 3, 6217, 4907, 1007, 43, 5310, 3543, 17, 3892, 11015, 18, 2321, 3582, 5889, 7969, 27099, 1930, 3990, 9626, 22523, 27099, 1985, 4664, 1922, 1920, 3109, 3]}, "items": [{"id": "p_2280", "content": "normeperidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5308, 11972, 5802, 3, 3]}]}
{"query": {"id": "q_2281", "content": "toxicity [SEP] entral nervous system excitation. No other risk factors for CNS toxicity were identified. This method allowed frequent self-dosing of pe", "tokenized_content": [2, 5532, 3, 5695, 1923, 7580, 2433, 8392, 18, 2239, 2303, 2565, 2790, 1958, 7520, 5532, 1985, 2899, 18, 2052, 2417, 5563, 6439, 3543, 17, 10654, 1927, 2737, 3]}, "items": [{"id": "p_2281", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2282", "content": "vanishing bile duct [SEP] Drug-associated acute-onset vanishing bile duct and Stevens-Johnson syndromes in a child.", "tokenized_content": [2, 7409, 13569, 9619, 10840, 3, 2838, 17, 2458, 3939, 17, 4727, 7409, 13569, 9619, 10840, 1930, 26913, 2099, 17, 13890, 12688, 1922, 43, 2748, 18, 3]}, "items": [{"id": "p_2282", "content": "Bile Duct Diseases [SEP] Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT", "score": 1, "type": null, "tokenized_content": [2, 9619, 10840, 3902, 3, 3902, 1922, 2967, 3131, 1927, 1920, 15154, 2433, 1927, 1920, 13210, 6482, 2037, 1920, 14274, 9619, 11152, 16058, 1033, 1942, 1920, 7585, 3059, 9619, 10840, 3]}]}
{"query": {"id": "q_2283", "content": "Stevens-Johnson syndromes [SEP] Drug-associated acute-onset vanishing bile duct and Stevens-Johnson syndromes in a child.", "tokenized_content": [2, 26913, 2099, 17, 13890, 12688, 3, 2838, 17, 2458, 3939, 17, 4727, 7409, 13569, 9619, 10840, 1930, 26913, 2099, 17, 13890, 12688, 1922, 43, 2748, 18, 3]}, "items": [{"id": "p_2283", "content": "Stevens-Johnson Syndrome [SEP] Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement.", "score": 1, "type": null, "tokenized_content": [2, 26913, 2099, 17, 13890, 4741, 3, 5844, 11276, 25655, 4378, 2007, 6475, 21771, 4091, 3864, 1922, 4407, 16293, 1956, 9565, 5668, 18, 3]}]}
{"query": {"id": "q_2284", "content": "vanishing bile duct [SEP] Acute vanishing bile duct syndrome is a rare but established cause of progressive cholest", "tokenized_content": [2, 7409, 13569, 9619, 10840, 3, 3939, 7409, 13569, 9619, 10840, 4741, 1977, 43, 5844, 2308, 4379, 3936, 1927, 7529, 21211, 3]}, "items": [{"id": "p_2284", "content": "Bile Duct Diseases [SEP] Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT", "score": 1, "type": null, "tokenized_content": [2, 9619, 10840, 3902, 3, 3902, 1922, 2967, 3131, 1927, 1920, 15154, 2433, 1927, 1920, 13210, 6482, 2037, 1920, 14274, 9619, 11152, 16058, 1033, 1942, 1920, 7585, 3059, 9619, 10840, 3]}]}
{"query": {"id": "q_2285", "content": "cholestasis [SEP] le duct syndrome is a rare but established cause of progressive cholestasis in adults, is most often drug or toxin related, and is of unkno", "tokenized_content": [2, 30086, 3, 2071, 10840, 4741, 1977, 43, 5844, 2308, 4379, 3936, 1927, 7529, 30086, 1922, 4440, 16, 1977, 2501, 3868, 2838, 2014, 9165, 2712, 16, 1930, 1977, 1927, 5423, 1037, 3]}, "items": [{"id": "p_2285", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_2286", "content": "Stevens-Johnson syndrome [SEP]  pathogenesis. It has not been reported previously in children. Stevens-Johnson syndrome is a well-recognized immune complex-mediated hypersensitivity r", "tokenized_content": [2, 26913, 2099, 17, 13890, 4741, 3, 6559, 18, 2176, 2258, 2084, 2252, 2568, 3024, 1922, 3069, 18, 26913, 2099, 17, 13890, 4741, 1977, 43, 2486, 17, 6783, 3743, 2796, 17, 3]}, "items": [{"id": "p_2286", "content": "Stevens-Johnson Syndrome [SEP] Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement.", "score": 1, "type": null, "tokenized_content": [2, 26913, 2099, 17, 13890, 4741, 3, 5844, 11276, 25655, 4378, 2007, 6475, 21771, 4091, 3864, 1922, 4407, 16293, 1956, 9565, 5668, 18, 3]}]}
{"query": {"id": "q_2287", "content": "hypersensitivity [SEP] s-Johnson syndrome is a well-recognized immune complex-mediated hypersensitivity reaction that affects all age groups, is drug or infection indu", "tokenized_content": [2, 14625, 3, 61, 17, 13890, 4741, 1977, 43, 2486, 17, 6783, 3743, 2796, 17, 3434, 14625, 3227, 1988, 6886, 2136, 2632, 2671, 16, 1977, 2838, 2014, 2909, 2063, 1032, 3]}, "items": [{"id": "p_2287", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_2288", "content": "infection [SEP] persensitivity reaction that affects all age groups, is drug or infection induced, and has classic systemic, mucosal, and dermatologic ma", "tokenized_content": [2, 2909, 3, 3096, 11142, 3227, 1988, 6886, 2136, 2632, 2671, 16, 1977, 2838, 2014, 2909, 2719, 16, 1930, 2258, 12211, 5510, 16, 9565, 16, 1930, 13467, 4467, 2488, 3]}, "items": [{"id": "p_2288", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_2289", "content": "vanishing bile duct syndrome [SEP] Acute vanishing bile duct syndrome is a rare but established cause of progressive cholestasis in a", "tokenized_content": [2, 7409, 13569, 9619, 10840, 4741, 3, 3939, 7409, 13569, 9619, 10840, 4741, 1977, 43, 5844, 2308, 4379, 3936, 1927, 7529, 30086, 1922, 43, 3]}, "items": [{"id": "p_2289", "content": "Bile Duct Diseases [SEP] Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT", "score": 1, "type": null, "tokenized_content": [2, 9619, 10840, 3902, 3, 3902, 1922, 2967, 3131, 1927, 1920, 15154, 2433, 1927, 1920, 13210, 6482, 2037, 1920, 14274, 9619, 11152, 16058, 1033, 1942, 1920, 7585, 3059, 9619, 10840, 3]}]}
{"query": {"id": "q_2290", "content": "ibuprofen [SEP] nson syndrome is described; this was temporally associated with ibuprofen use. Despite therapy with ursodeoxycholic acid, prednisone, and", "tokenized_content": [2, 24089, 3, 4246, 1916, 4741, 1977, 2910, 31, 2052, 1982, 17579, 2458, 1956, 24089, 2485, 18, 4281, 3181, 1956, 29321, 21554, 3204, 4485, 2687, 16, 20405, 16, 1930, 3]}, "items": [{"id": "p_2290", "content": "Ibuprofen [SEP] A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24089, 3, 43, 29413, 2246, 17, 3769, 5899, 1956, 14501, 3879, 2251, 1922, 1920, 3181, 1927, 10939, 2421, 1930, 8884, 18, 3]}]}
{"query": {"id": "q_2291", "content": "ursodeoxycholic acid [SEP]  temporally associated with ibuprofen use. Despite therapy with ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestatic disease was u", "tokenized_content": [2, 29321, 21554, 3204, 4485, 2687, 3, 17579, 2458, 1956, 24089, 2485, 18, 4281, 3181, 1956, 29321, 21554, 3204, 4485, 2687, 16, 20405, 16, 1930, 2759, 21801, 16, 3656, 21211, 2479, 3]}, "items": [{"id": "p_2291", "content": "Ursodeoxycholic Acid [SEP] An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or ", "score": 1, "type": null, "tokenized_content": [2, 29321, 21554, 3204, 4485, 2687, 3, 1925, 13872, 9213, 1927, 10280, 21554, 3204, 4485, 2687, 18, 2176, 1977, 43, 6492, 9619, 2687, 2435, 2561, 1922, 1920, 16969, 1930, 1977, 10535, 3108, 43, 7897, 2014, 3]}]}
{"query": {"id": "q_2292", "content": "prednisone [SEP]  with ibuprofen use. Despite therapy with ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestatic disease was unrelenting, ", "tokenized_content": [2, 20405, 3, 1956, 24089, 2485, 18, 4281, 3181, 1956, 29321, 21554, 3204, 4485, 2687, 16, 20405, 16, 1930, 2759, 21801, 16, 3656, 21211, 2479, 2573, 1982, 24028, 4132, 16, 3]}, "items": [{"id": "p_2292", "content": "Prednisone [SEP] A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in t", "score": 1, "type": null, "tokenized_content": [2, 20405, 3, 43, 6830, 2246, 17, 3769, 14469, 3595, 2037, 18964, 8142, 1021, 18, 2176, 1977, 12186, 22937, 1930, 9076, 1942, 22025, 1922, 62, 3]}]}
{"query": {"id": "q_2293", "content": "tacrolimus [SEP] Despite therapy with ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestatic disease was unrelenting, with cirrhosis shown ", "tokenized_content": [2, 21801, 3, 4281, 3181, 1956, 29321, 21554, 3204, 4485, 2687, 16, 20405, 16, 1930, 2759, 21801, 16, 3656, 21211, 2479, 2573, 1982, 24028, 4132, 16, 1956, 11260, 2522, 3]}, "items": [{"id": "p_2293", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_2294", "content": "cholestatic disease [SEP] with ursodeoxycholic acid, prednisone, and then tacrolimus, her cholestatic disease was unrelenting, with cirrhosis shown by biopsy 6 months after ", "tokenized_content": [2, 21211, 2479, 2573, 3, 1956, 29321, 21554, 3204, 4485, 2687, 16, 20405, 16, 1930, 2759, 21801, 16, 3656, 21211, 2479, 2573, 1982, 24028, 4132, 16, 1956, 11260, 2522, 2007, 6831, 3]}, "items": [{"id": "p_2294", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_2295", "content": "cirrhosis [SEP]  then tacrolimus, her cholestatic disease was unrelenting, with cirrhosis shown by biopsy 6 months after presentation. This case document", "tokenized_content": [2, 11260, 3, 2759, 21801, 16, 3656, 21211, 2479, 2573, 1982, 24028, 4132, 16, 1956, 11260, 2522, 2007, 6831, 26, 3221, 2256, 6544, 18, 2052, 3087, 5618, 3]}, "items": [{"id": "p_2295", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_2296", "content": "primary pulmonary hypertension [SEP] High incidence of primary pulmonary hypertension associated with appetite suppressants in Belgium.", "tokenized_content": [2, 3065, 5352, 5579, 3, 2149, 4332, 1927, 3065, 5352, 5579, 2458, 1956, 17990, 4400, 2356, 1922, 18743, 18, 3]}, "items": [{"id": "p_2296", "content": "Hypertension, Pulmonary [SEP] Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 5352, 3, 2502, 4541, 3554, 1922, 1920, 5352, 9255, 16, 5394, 4067, 1942, 4003, 3902, 2014, 3614, 3902, 18, 3]}]}
{"query": {"id": "q_2297", "content": "appetite suppressants [SEP] igh incidence of primary pulmonary hypertension associated with appetite suppressants in Belgium.", "tokenized_content": [2, 17990, 4400, 2356, 3, 20733, 4332, 1927, 3065, 5352, 5579, 2458, 1956, 17990, 4400, 2356, 1922, 18743, 18, 3]}, "items": [{"id": "p_2297", "content": "Appetite Depressants [SEP] Agents that are used to suppress appetite.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17990, 20852, 2356, 3, 4820, 1988, 2032, 2251, 1942, 4400, 17990, 18, 3]}]}
{"query": {"id": "q_2298", "content": "Primary pulmonary hypertension [SEP] Primary pulmonary hypertension is a rare, progressive and incurable disease, which has been as", "tokenized_content": [2, 3065, 5352, 5579, 3, 3065, 5352, 5579, 1977, 43, 5844, 16, 7529, 1930, 2043, 12478, 2573, 16, 2154, 2258, 2252, 1966, 3]}, "items": [{"id": "p_2298", "content": "Hypertension, Pulmonary [SEP] Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 5352, 3, 2502, 4541, 3554, 1922, 1920, 5352, 9255, 16, 5394, 4067, 1942, 4003, 3902, 2014, 3614, 3902, 18, 3]}]}
{"query": {"id": "q_2299", "content": "appetite suppressant [SEP] incurable disease, which has been associated with the intake of appetite suppressant drugs. The importance of this association was evaluated in Belg", "tokenized_content": [2, 17990, 4400, 2031, 3, 2043, 12478, 2573, 16, 2154, 2258, 2252, 2458, 1956, 1920, 5240, 1927, 17990, 4400, 2031, 4195, 18, 1920, 4737, 1927, 2052, 3279, 1982, 3747, 1922, 16690, 3]}, "items": [{"id": "p_2299", "content": "Appetite Depressants [SEP] Agents that are used to suppress appetite.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17990, 20852, 2356, 3, 4820, 1988, 2032, 2251, 1942, 4400, 17990, 18, 3]}]}
{"query": {"id": "q_2300", "content": "appetite suppressants [SEP] le this country still had no restriction on the prescription of appetite suppressants. Thirty-five patients with primary pulmonary hypertension and 8", "tokenized_content": [2, 17990, 4400, 2356, 3, 2071, 2052, 7722, 3974, 2430, 2239, 7587, 1990, 1920, 10524, 1927, 17990, 4400, 2356, 18, 9942, 17, 3628, 2132, 1956, 3065, 5352, 5579, 1930, 28, 3]}, "items": [{"id": "p_2300", "content": "Appetite Depressants [SEP] Agents that are used to suppress appetite.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17990, 20852, 2356, 3, 4820, 1988, 2032, 2251, 1942, 4400, 17990, 18, 3]}]}
{"query": {"id": "q_2301", "content": "primary pulmonary hypertension [SEP] rescription of appetite suppressants. Thirty-five patients with primary pulmonary hypertension and 85 matched controls were recruited over 32 months (1992-199", "tokenized_content": [2, 3065, 5352, 5579, 3, 7615, 3027, 2929, 1927, 17990, 4400, 2356, 18, 9942, 17, 3628, 2132, 1956, 3065, 5352, 5579, 1930, 5140, 5992, 3562, 1985, 6878, 2338, 3323, 3221, 12, 3]}, "items": [{"id": "p_2301", "content": "Hypertension, Pulmonary [SEP] Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 5352, 3, 2502, 4541, 3554, 1922, 1920, 5352, 9255, 16, 5394, 4067, 1942, 4003, 3902, 2014, 3614, 3902, 18, 3]}]}
{"query": {"id": "q_2302", "content": "appetite-suppressants [SEP] re recruited over 32 months (1992-1994) in Belgium. Exposure to appetite-suppressants was assessed on the basis of hospital records and standardized ", "tokenized_content": [2, 17990, 17, 4400, 2356, 3, 1964, 6878, 2338, 3323, 3221, 12, 8348, 17, 7319, 13, 1922, 18743, 18, 3395, 1942, 17990, 17, 4400, 2356, 1982, 3683, 1990, 1920, 4859, 1927, 3]}, "items": [{"id": "p_2302", "content": "Appetite Depressants [SEP] Agents that are used to suppress appetite.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17990, 20852, 2356, 3, 4820, 1988, 2032, 2251, 1942, 4400, 17990, 18, 3]}]}
{"query": {"id": "q_2303", "content": "fenfluramines [SEP] the patients had previously taken appetite suppressants, mainly fenfluramines, as compared with only 5 of the controls (66 versus 6%, p<0.000", "tokenized_content": [2, 15096, 12353, 14286, 3, 1920, 2132, 2430, 3024, 4208, 17990, 4400, 2356, 16, 4994, 15096, 12353, 14286, 16, 1966, 2452, 1956, 2444, 25, 1927, 1920, 3562, 12, 4970, 4072, 26, 3]}, "items": [{"id": "p_2303", "content": "Fenfluramine [SEP] A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15096, 12353, 3812, 3, 43, 20424, 3500, 2838, 1988, 10535, 2321, 7644, 11153, 5047, 1930, 2463, 18118, 4860, 17, 3434, 11153, 4012, 18, 3]}]}
{"query": {"id": "q_2304", "content": "Choreoathetoid movements [SEP] Choreoathetoid movements associated with rapid adjustment to methadone.", "tokenized_content": [2, 11418, 1021, 6952, 20536, 4575, 1960, 8264, 3, 11418, 1021, 6952, 20536, 4575, 1960, 8264, 2458, 1956, 4052, 7970, 1942, 20293, 18, 3]}, "items": [{"id": "p_2304", "content": "Chorea [SEP] Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movem", "score": 1, "type": null, "tokenized_content": [2, 11418, 5376, 3, 28493, 16, 1958, 3349, 7272, 16, 4052, 16, 26482, 6716, 8264, 1988, 2278, 1998, 12842, 2014, 5433, 17571, 16, 7686, 12571, 2791, 4147, 1927, 6532, 1035, 3]}]}
{"query": {"id": "q_2305", "content": "methadone [SEP] Choreoathetoid movements associated with rapid adjustment to methadone.", "tokenized_content": [2, 20293, 3, 11418, 1021, 6952, 20536, 4575, 1960, 8264, 2458, 1956, 4052, 7970, 1942, 20293, 18, 3]}, "items": [{"id": "p_2305", "content": "Methadone [SEP] A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has ac", "score": 1, "type": null, "tokenized_content": [2, 20293, 3, 43, 6830, 9384, 1988, 1977, 2251, 1966, 1920, 16675, 18, 2176, 1977, 1925, 9384, 14501, 1988, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 2176, 2258, 2000, 3]}]}
{"query": {"id": "q_2306", "content": "Choreatiform [SEP] Choreatiform hyperkinesias are known to be occasional movement abnormalities", "tokenized_content": [2, 11418, 5376, 29649, 3, 11418, 5376, 29649, 4194, 26682, 1036, 2032, 3171, 1942, 1998, 18838, 5829, 6754, 3]}, "items": [{"id": "p_2306", "content": "Chorea [SEP] Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movem", "score": 1, "type": null, "tokenized_content": [2, 11418, 5376, 3, 28493, 16, 1958, 3349, 7272, 16, 4052, 16, 26482, 6716, 8264, 1988, 2278, 1998, 12842, 2014, 5433, 17571, 16, 7686, 12571, 2791, 4147, 1927, 6532, 1035, 3]}]}
{"query": {"id": "q_2307", "content": "hyperkinesias [SEP] Choreatiform hyperkinesias are known to be occasional movement abnormalities during intoxi", "tokenized_content": [2, 4194, 26682, 1036, 3, 11418, 5376, 29649, 4194, 26682, 1036, 2032, 3171, 1942, 1998, 18838, 5829, 6754, 2409, 20848, 1033, 3]}, "items": [{"id": "p_2307", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_2308", "content": "movement abnormalities [SEP] Choreatiform hyperkinesias are known to be occasional movement abnormalities during intoxications with cocaine but not opiates. This is a ca", "tokenized_content": [2, 5829, 6754, 3, 11418, 5376, 29649, 4194, 26682, 1036, 2032, 3171, 1942, 1998, 18838, 5829, 6754, 2409, 20965, 1036, 1956, 9045, 2308, 2084, 27059, 1036, 18, 2052, 1977, 43, 2332, 3]}, "items": [{"id": "p_2308", "content": "Dyskinesias [SEP] Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underly", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 1036, 3, 4552, 28493, 8264, 2154, 5985, 4081, 1920, 18884, 16, 13717, 16, 2014, 16795, 1988, 4704, 1966, 43, 15570, 1927, 1925, 9886, 1012, 3]}]}
{"query": {"id": "q_2309", "content": "cocaine [SEP]  be occasional movement abnormalities during intoxications with cocaine but not opiates. This is a case report of euphoria and choreoat", "tokenized_content": [2, 9045, 3, 1998, 18838, 5829, 6754, 2409, 20965, 1036, 1956, 9045, 2308, 2084, 27059, 1036, 18, 2052, 1977, 43, 3087, 3809, 1927, 4791, 2102, 26577, 1930, 11418, 1021, 6952, 1031, 3]}, "items": [{"id": "p_2309", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2310", "content": "choreoathetoid movements [SEP]  cocaine but not opiates. This is a case report of euphoria and choreoathetoid movements both transiently induced by rapid adjustment to the selective m", "tokenized_content": [2, 11418, 1021, 6952, 20536, 4575, 1960, 8264, 3, 9045, 2308, 2084, 27059, 1036, 18, 2052, 1977, 43, 3087, 3809, 1927, 4791, 2102, 26577, 1930, 11418, 1021, 6952, 20536, 4575, 1960, 3]}, "items": [{"id": "p_2310", "content": "Chorea [SEP] Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movem", "score": 1, "type": null, "tokenized_content": [2, 11418, 5376, 3, 28493, 16, 1958, 3349, 7272, 16, 4052, 16, 26482, 6716, 8264, 1988, 2278, 1998, 12842, 2014, 5433, 17571, 16, 7686, 12571, 2791, 4147, 1927, 6532, 1035, 3]}]}
{"query": {"id": "q_2311", "content": "methadone [SEP] by rapid adjustment to the selective mu-opioid receptor agonist methadone in an inpatient previously abusing heroine and cocaine. In addi", "tokenized_content": [2, 20293, 3, 2007, 4052, 7970, 1942, 1920, 5328, 8975, 17, 9384, 3148, 7829, 20293, 1922, 1925, 12037, 3024, 2186, 16435, 19175, 1021, 1930, 9045, 18, 1922, 3019, 1033, 3]}, "items": [{"id": "p_2311", "content": "Methadone [SEP] A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has ac", "score": 1, "type": null, "tokenized_content": [2, 20293, 3, 43, 6830, 9384, 1988, 1977, 2251, 1966, 1920, 16675, 18, 2176, 1977, 1925, 9384, 14501, 1988, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 2176, 2258, 2000, 3]}]}
{"query": {"id": "q_2312", "content": "heroine [SEP] d receptor agonist methadone in an inpatient previously abusing heroine and cocaine. In addition, minor EEG abnormalities occurred. Pos", "tokenized_content": [2, 19175, 1021, 3, 46, 3148, 7829, 20293, 1922, 1925, 12037, 3024, 2186, 16435, 19175, 1021, 1930, 9045, 18, 1922, 2459, 16, 5857, 9052, 6754, 4807, 18, 2159, 3]}, "items": [{"id": "p_2312", "content": "Heroin [SEP] A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Feder", "score": 1, "type": null, "tokenized_content": [2, 19175, 3, 43, 22872, 3153, 14501, 1988, 2278, 1998, 7954, 17, 7402, 18, 2176, 1977, 43, 4642, 7311, 12, 7976, 1989, 10533, 13, 7663, 1922, 1920, 63, 18, 61, 18, 7815, 1927, 5788, 1915, 3]}]}
{"query": {"id": "q_2313", "content": "Cocaine [SEP] Cocaine-induced mood disorder: prevalence rates and psychiatric symptom", "tokenized_content": [2, 9045, 3, 9045, 17, 2719, 9494, 4770, 30, 4077, 3389, 1930, 7652, 3226, 3]}, "items": [{"id": "p_2313", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2314", "content": "mood disorder [SEP] Cocaine-induced mood disorder: prevalence rates and psychiatric symptoms in an outpatient coc", "tokenized_content": [2, 9494, 4770, 3, 9045, 17, 2719, 9494, 4770, 30, 4077, 3389, 1930, 7652, 3601, 1922, 1925, 10037, 6880, 3]}, "items": [{"id": "p_2314", "content": "Mood Disorders [SEP] Those disorders that have a disturbance in mood as their predominant feature.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9494, 4414, 3, 2690, 4414, 1988, 2162, 43, 12732, 1922, 9494, 1966, 2310, 6136, 5961, 18, 3]}]}
{"query": {"id": "q_2315", "content": "psychiatric [SEP] Cocaine-induced mood disorder: prevalence rates and psychiatric symptoms in an outpatient cocaine-dependent sample.", "tokenized_content": [2, 7652, 3, 9045, 17, 2719, 9494, 4770, 30, 4077, 3389, 1930, 7652, 3601, 1922, 1925, 10037, 9045, 17, 3100, 2983, 18, 3]}, "items": [{"id": "p_2315", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_2316", "content": "cocaine [SEP] der: prevalence rates and psychiatric symptoms in an outpatient cocaine-dependent sample.", "tokenized_content": [2, 9045, 3, 3135, 30, 4077, 3389, 1930, 7652, 3601, 1922, 1925, 10037, 9045, 17, 3100, 2983, 18, 3]}, "items": [{"id": "p_2316", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2317", "content": "mood disorders [SEP] e rates and symptom patterns of DSM substance-induced and other mood disorders. 243 cocaine-dependent outpatients with cocaine-induced mood di", "tokenized_content": [2, 9494, 4414, 3, 47, 3389, 1930, 3226, 4147, 1927, 10964, 7311, 17, 2719, 1930, 2303, 9494, 4414, 18, 20489, 9045, 17, 3100, 20204, 1956, 9045, 17, 2719, 9494, 2137, 3]}, "items": [{"id": "p_2317", "content": "Mood Disorders [SEP] Those disorders that have a disturbance in mood as their predominant feature.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9494, 4414, 3, 2690, 4414, 1988, 2162, 43, 12732, 1922, 9494, 1966, 2310, 6136, 5961, 18, 3]}]}
{"query": {"id": "q_2318", "content": "cocaine [SEP] patterns of DSM substance-induced and other mood disorders. 243 cocaine-dependent outpatients with cocaine-induced mood disorder (CIMD)", "tokenized_content": [2, 9045, 3, 4147, 1927, 10964, 7311, 17, 2719, 1930, 2303, 9494, 4414, 18, 20489, 9045, 17, 3100, 20204, 1956, 9045, 17, 2719, 9494, 4770, 12, 20090, 1007, 13, 3]}, "items": [{"id": "p_2318", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2319", "content": "mood disorder [SEP] e rates and symptom patterns of DSM substance-induced and other mood disorders. 243 cocaine-dependent outpatients with cocaine-induced mood d", "tokenized_content": [2, 9494, 4770, 3, 47, 3389, 1930, 3226, 4147, 1927, 10964, 7311, 17, 2719, 1930, 2303, 9494, 4414, 18, 20489, 9045, 17, 3100, 20204, 1956, 9045, 17, 2719, 9494, 46, 3]}, "items": [{"id": "p_2319", "content": "Mood Disorders [SEP] Those disorders that have a disturbance in mood as their predominant feature.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9494, 4414, 3, 2690, 4414, 1988, 2162, 43, 12732, 1922, 9494, 1966, 2310, 6136, 5961, 18, 3]}]}
{"query": {"id": "q_2320", "content": "CIMD [SEP] caine-dependent outpatients with cocaine-induced mood disorder (CIMD), other mood disorders, or no mood disorder were compared on me", "tokenized_content": [2, 20090, 1007, 3, 23785, 2912, 17, 3100, 20204, 1956, 9045, 17, 2719, 9494, 4770, 12, 20090, 1007, 13, 16, 2303, 9494, 4414, 16, 2014, 2239, 9494, 4770, 1985, 2452, 1990, 3]}, "items": [{"id": "p_2320", "content": "Cocaine-Related Disorders [SEP] Disorders related or resulting from use of cocaine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9045, 17, 2712, 4414, 3, 4414, 2712, 2014, 3864, 2037, 2485, 1927, 9045, 18, 3]}]}
{"query": {"id": "q_2321", "content": "psychiatric [SEP] ood disorders, or no mood disorder were compared on measures of psychiatric symptoms. The prevalence rate for CIMD was 12% at baseline. Int", "tokenized_content": [2, 7652, 3, 57, 1986, 4414, 16, 2014, 2239, 9494, 4770, 1985, 2452, 1990, 3975, 1927, 7652, 3601, 18, 1920, 4077, 2769, 1958, 20090, 1007, 1982, 2369, 9, 2019, 3703, 18, 3]}, "items": [{"id": "p_2321", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_2322", "content": "depressive disorders [SEP] agnosis of CIMD did not substantially affect rates of the other depressive disorders. Patients with CIMD had symptom severity levels between those o", "tokenized_content": [2, 7745, 4414, 3, 21790, 2475, 1927, 20090, 1007, 2811, 2084, 7878, 4081, 3389, 1927, 1920, 2303, 7745, 4414, 18, 2132, 1956, 20090, 1007, 2430, 3226, 5155, 2428, 2192, 2690, 57, 3]}, "items": [{"id": "p_2322", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_2323", "content": "Hemolysis [SEP] Hemolysis of human erythrocytes induced by tamoxifen is related to disrup", "tokenized_content": [2, 22409, 3, 22409, 1927, 2616, 14161, 2719, 2007, 13011, 1977, 2712, 1942, 5196, 1034, 3]}, "items": [{"id": "p_2323", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_2324", "content": "tamoxifen [SEP] Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure.", "tokenized_content": [2, 13011, 3, 22409, 1927, 2616, 14161, 2719, 2007, 13011, 1977, 2712, 1942, 7561, 1927, 3260, 3170, 18, 3]}, "items": [{"id": "p_2324", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_2325", "content": "Tamoxifen [SEP] Tamoxifen (TAM), the antiestrogenic drug most widely prescribed in the ch", "tokenized_content": [2, 13011, 3, 13011, 12, 9066, 13, 16, 1920, 2246, 21976, 1935, 2838, 2501, 5673, 9975, 1922, 1920, 2016, 3]}, "items": [{"id": "p_2325", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_2326", "content": "TAM [SEP] Tamoxifen (TAM), the antiestrogenic drug most widely prescribed in the chemoth", "tokenized_content": [2, 9066, 3, 13011, 12, 9066, 13, 16, 1920, 2246, 21976, 1935, 2838, 2501, 5673, 9975, 1922, 1920, 12776, 1023, 3]}, "items": [{"id": "p_2326", "content": "Tamoxifen [SEP] One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibitin", "score": 1, "type": null, "tokenized_content": [2, 13011, 3, 2340, 1927, 1920, 5328, 7940, 3148, 17455, 1956, 2960, 17, 2487, 4209, 18, 13011, 8016, 1966, 1925, 2246, 17, 7940, 12, 2875, 1921, 3]}]}
{"query": {"id": "q_2327", "content": "breast cancer [SEP] tiestrogenic drug most widely prescribed in the chemotherapy of breast cancer, induces changes in normal discoid shape of erythrocytes and he", "tokenized_content": [2, 3739, 2539, 3, 25439, 1997, 3880, 2838, 2501, 5673, 9975, 1922, 1920, 5318, 1927, 3739, 2539, 16, 6387, 2840, 1922, 2791, 2863, 2642, 5989, 1927, 14161, 1930, 2234, 3]}, "items": [{"id": "p_2327", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_2328", "content": "hemolytic anemia [SEP] er, induces changes in normal discoid shape of erythrocytes and hemolytic anemia. This work evaluates the effects of TAM on isolated human eryth", "tokenized_content": [2, 21515, 10679, 3, 2668, 16, 6387, 2840, 1922, 2791, 2863, 2642, 5989, 1927, 14161, 1930, 21515, 10679, 18, 2052, 2778, 22494, 1920, 2564, 1927, 9066, 1990, 3937, 2616, 6549, 3]}, "items": [{"id": "p_2328", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_2329", "content": "hemolysis [SEP] f biomembranes in its cytostatic action mechanisms. TAM induces hemolysis of erythrocytes as a function of concentration. The extension o", "tokenized_content": [2, 22409, 3, 48, 4071, 8591, 1036, 1922, 2496, 5521, 3857, 2002, 4615, 3531, 18, 9066, 6387, 22409, 1927, 14161, 1966, 43, 2347, 1927, 3110, 18, 1920, 7140, 57, 3]}, "items": [{"id": "p_2329", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_2330", "content": "hemolytic [SEP] er, induces changes in normal discoid shape of erythrocytes and hemolytic anemia. This work evaluates the effects of TAM on isolated huma", "tokenized_content": [2, 21515, 3, 2668, 16, 6387, 2840, 1922, 2791, 2863, 2642, 5989, 1927, 14161, 1930, 21515, 10679, 18, 2052, 2778, 22494, 1920, 2564, 1927, 9066, 1990, 3937, 2490, 1019, 3]}, "items": [{"id": "p_2330", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_2331", "content": "alpha-tocopherol [SEP] e hemolytic effect of TAM is prevented by low concentrations of alpha-tocopherol (alpha-T) and alpha-tocopherol acetate (alpha-TAc) (inactivated", "tokenized_content": [2, 4595, 17, 21432, 3, 47, 21515, 2495, 1927, 9066, 1977, 8715, 2007, 2330, 3295, 1927, 4595, 17, 21432, 12, 4595, 17, 62, 13, 1930, 4595, 17, 21432, 7959, 12, 4595, 3]}, "items": [{"id": "p_2331", "content": "alpha-Tocopherol [SEP] A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the pheno", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 21432, 3, 43, 4613, 21432, 1930, 2340, 1927, 1920, 2501, 6828, 7335, 21432, 1036, 18, 2176, 9826, 7335, 2455, 2007, 25130, 1927, 1920, 3037, 1037, 3]}]}
{"query": {"id": "q_2332", "content": "alpha-T [SEP]  of TAM is prevented by low concentrations of alpha-tocopherol (alpha-T) and alpha-tocopherol acetate (alpha-TAc) (inactivated function", "tokenized_content": [2, 4595, 17, 62, 3, 1927, 9066, 1977, 8715, 2007, 2330, 3295, 1927, 4595, 17, 21432, 12, 4595, 17, 62, 13, 1930, 4595, 17, 21432, 7959, 12, 4595, 17, 9214, 13, 3]}, "items": [{"id": "p_2332", "content": "alpha-Tocopherol [SEP] A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the pheno", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 21432, 3, 43, 4613, 21432, 1930, 2340, 1927, 1920, 2501, 6828, 7335, 21432, 1036, 18, 2176, 9826, 7335, 2455, 2007, 25130, 1927, 1920, 3037, 1037, 3]}]}
{"query": {"id": "q_2333", "content": "alpha-tocopherol acetate [SEP] evented by low concentrations of alpha-tocopherol (alpha-T) and alpha-tocopherol acetate (alpha-TAc) (inactivated functional hydroxyl) indicating that T", "tokenized_content": [2, 4595, 17, 21432, 7959, 3, 4817, 1919, 2007, 2330, 3295, 1927, 4595, 17, 21432, 12, 4595, 17, 62, 13, 1930, 4595, 17, 21432, 7959, 12, 4595, 17, 9214, 13, 12, 3]}, "items": [{"id": "p_2333", "content": "alpha-Tocopherol [SEP] A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the pheno", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 21432, 3, 43, 4613, 21432, 1930, 2340, 1927, 1920, 2501, 6828, 7335, 21432, 1036, 18, 2176, 9826, 7335, 2455, 2007, 25130, 1927, 1920, 3037, 1037, 3]}]}
{"query": {"id": "q_2334", "content": "alpha-TAc [SEP] ons of alpha-tocopherol (alpha-T) and alpha-tocopherol acetate (alpha-TAc) (inactivated functional hydroxyl) indicating that TAM-induced ", "tokenized_content": [2, 4595, 17, 9214, 3, 24335, 1927, 4595, 17, 21432, 12, 4595, 17, 62, 13, 1930, 4595, 17, 21432, 7959, 12, 4595, 17, 9214, 13, 12, 11588, 3183, 9420, 13, 4168, 3]}, "items": [{"id": "p_2334", "content": "alpha-Tocopherol [SEP] A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the pheno", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 21432, 3, 43, 4613, 21432, 1930, 2340, 1927, 1920, 2501, 6828, 7335, 21432, 1036, 18, 2176, 9826, 7335, 2455, 2007, 25130, 1927, 1920, 3037, 1037, 3]}]}
{"query": {"id": "q_2335", "content": "hydroxyl [SEP] nd alpha-tocopherol acetate (alpha-TAc) (inactivated functional hydroxyl) indicating that TAM-induced hemolysis is not related to oxidat", "tokenized_content": [2, 9420, 3, 8026, 4595, 17, 21432, 7959, 12, 4595, 17, 9214, 13, 12, 11588, 3183, 9420, 13, 4168, 1988, 9066, 17, 2719, 22409, 1977, 2084, 2712, 1942, 3618, 1926, 3]}, "items": [{"id": "p_2335", "content": "Hydroxyl Radical [SEP] The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9420, 6917, 3, 1920, 23488, 16896, 6917, 5622, 18, 9420, 6917, 1977, 43, 6828, 23669, 5899, 18, 3]}]}
{"query": {"id": "q_2336", "content": "oxygen [SEP] ative membrane damage. This was further evidenced by absence of oxygen consumption and hemoglobin oxidation both determined in paralle", "tokenized_content": [2, 4612, 3, 2019, 2320, 3260, 4293, 18, 2052, 1982, 2520, 11400, 2007, 3905, 1927, 4612, 5434, 1930, 9652, 6638, 2321, 3180, 1922, 22415, 1021, 3]}, "items": [{"id": "p_2336", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_2337", "content": "AAPH [SEP]  TAM inhibits the peroxidation of human erythrocytes induced by AAPH, thus ruling out TAM-induced cell oxidative stress. Hemolysis c", "tokenized_content": [2, 24349, 1023, 3, 9066, 7042, 1920, 14214, 1927, 2616, 14161, 2719, 2007, 24349, 1023, 16, 2842, 7212, 3961, 2397, 9066, 17, 2719, 2024, 5163, 3071, 18, 22409, 45, 3]}, "items": [{"id": "p_2337", "content": "2,2'-azobis(2-amidinopropane) [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 16, 22, 11, 17, 27381, 3821, 1036, 12, 22, 17, 28813, 3522, 20194, 2516, 13, 3, 3]}]}
{"query": {"id": "q_2338", "content": "Hemolysis [SEP] ced by AAPH, thus ruling out TAM-induced cell oxidative stress. Hemolysis caused by TAM was not preceded by the leakage of K(+) from the ", "tokenized_content": [2, 22409, 3, 19424, 2007, 24349, 1023, 16, 2842, 7212, 3961, 2397, 9066, 17, 2719, 2024, 5163, 3071, 18, 22409, 4189, 2007, 9066, 1982, 2084, 16757, 2007, 1920, 12493, 1927, 53, 3]}, "items": [{"id": "p_2338", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_2339", "content": "K [SEP] ess. Hemolysis caused by TAM was not preceded by the leakage of K(+) from the cells, also excluding a colloid-osmotic type mechan", "tokenized_content": [2, 53, 3, 4023, 18, 22409, 4189, 2007, 9066, 1982, 2084, 16757, 2007, 1920, 12493, 1927, 53, 12, 15, 13, 2037, 1920, 2094, 16, 2222, 10566, 43, 29914, 17, 13951, 2601, 3]}, "items": [{"id": "p_2339", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_2340", "content": "tocopherols [SEP] es. These effects suggest that the protection from hemolysis by tocopherols is related to a decreased TAM incorporation in condensed membra", "tokenized_content": [2, 21432, 1036, 3, 2376, 18, 2144, 2564, 3220, 1988, 1920, 6202, 2037, 22409, 2007, 21432, 1036, 1977, 2712, 1942, 43, 3261, 9066, 8629, 1922, 20481, 3033, 1019, 3]}, "items": [{"id": "p_2340", "content": "Tocopherols [SEP] A collective name for a group of closely related lipids that contain substitutions on the 2H-1-benzopyran-6-ol nucleus and a lon", "score": 1, "type": null, "tokenized_content": [2, 21432, 1036, 3, 43, 15189, 9533, 1958, 43, 2210, 1927, 6538, 2712, 8238, 1988, 5531, 10682, 1990, 1920, 7478, 17, 21, 17, 19225, 18425, 1928, 17, 26, 17, 2865, 5607, 1930, 43, 10969, 3]}]}
{"query": {"id": "q_2341", "content": "sodium [SEP] Changes of sodium and ATP affinities of the cardiac (Na,K)-ATPase during and afte", "tokenized_content": [2, 5227, 3, 2840, 1927, 5227, 1930, 4498, 15377, 1927, 1920, 4435, 12, 4049, 16, 53, 13, 17, 9444, 2409, 1930, 2221, 2057, 3]}, "items": [{"id": "p_2341", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_2342", "content": "ATP [SEP] Changes of sodium and ATP affinities of the cardiac (Na,K)-ATPase during and after nitric", "tokenized_content": [2, 4498, 3, 2840, 1927, 5227, 1930, 4498, 15377, 1927, 1920, 4435, 12, 4049, 16, 53, 13, 17, 9444, 2409, 1930, 2256, 10233, 3]}, "items": [{"id": "p_2342", "content": "Adenosine Triphosphate [SEP] An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in meta", "score": 1, "type": null, "tokenized_content": [2, 10125, 17978, 3, 1925, 15643, 5489, 3165, 2559, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 18, 1922, 2459, 1942, 2496, 6608, 5456, 1922, 5880, 3]}]}
{"query": {"id": "q_2343", "content": "Na [SEP] Changes of sodium and ATP affinities of the cardiac (Na,K)-ATPase during and after nitric oxide deficient hypertension.", "tokenized_content": [2, 4049, 3, 2840, 1927, 5227, 1930, 4498, 15377, 1927, 1920, 4435, 12, 4049, 16, 53, 13, 17, 9444, 2409, 1930, 2256, 10233, 7491, 5778, 5579, 18, 3]}, "items": [{"id": "p_2343", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_2344", "content": "K [SEP] Changes of sodium and ATP affinities of the cardiac (Na,K)-ATPase during and after nitric oxide deficient hypertension.", "tokenized_content": [2, 53, 3, 2840, 1927, 5227, 1930, 4498, 15377, 1927, 1920, 4435, 12, 4049, 16, 53, 13, 17, 9444, 2409, 1930, 2256, 10233, 7491, 5778, 5579, 18, 3]}, "items": [{"id": "p_2344", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_2345", "content": "nitric oxide [SEP] nd ATP affinities of the cardiac (Na,K)-ATPase during and after nitric oxide deficient hypertension.", "tokenized_content": [2, 10233, 7491, 3, 8026, 4498, 15377, 1927, 1920, 4435, 12, 4049, 16, 53, 13, 17, 9444, 2409, 1930, 2256, 10233, 7491, 5778, 5579, 18, 3]}, "items": [{"id": "p_2345", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_2346", "content": "hypertension [SEP] e cardiac (Na,K)-ATPase during and after nitric oxide deficient hypertension.", "tokenized_content": [2, 5579, 3, 47, 4435, 12, 4049, 16, 53, 13, 17, 9444, 2409, 1930, 2256, 10233, 7491, 5778, 5579, 18, 3]}, "items": [{"id": "p_2346", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2347", "content": "NO [SEP] In the cardiovascular system, NO is involved in the regulation of a variety of functions. Inhibi", "tokenized_content": [2, 2239, 3, 1922, 1920, 5321, 2433, 16, 2239, 1977, 3286, 1922, 1920, 3640, 1927, 43, 5386, 1927, 4088, 18, 2439, 1033, 3]}, "items": [{"id": "p_2347", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_2348", "content": "hypertension [SEP] iety of functions. Inhibition of NO synthesis induces sustained hypertension. In several models of hypertension, elevation of intracellular ", "tokenized_content": [2, 5579, 3, 10116, 3145, 1927, 4088, 18, 3523, 1927, 2239, 4271, 6387, 7637, 5579, 18, 1922, 2980, 3130, 1927, 5579, 16, 8644, 1927, 4776, 3]}, "items": [{"id": "p_2348", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2349", "content": "sodium [SEP] . In several models of hypertension, elevation of intracellular sodium level was documented in cardiac tissue. To assess the molecular", "tokenized_content": [2, 5227, 3, 18, 1922, 2980, 3130, 1927, 5579, 16, 8644, 1927, 4776, 5227, 2237, 1982, 6974, 1922, 4435, 2960, 18, 1942, 2634, 1920, 3272, 3]}, "items": [{"id": "p_2349", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_2350", "content": "Na [SEP] olecular basis of disturbances in transmembraneous transport of Na+, we studied the response of cardiac (Na,K)-ATPase to NO-defici", "tokenized_content": [2, 4049, 3, 12188, 18021, 5148, 1005, 4859, 1927, 12654, 1922, 9117, 2080, 4860, 1927, 4049, 15, 16, 2038, 3942, 1920, 2644, 1927, 4435, 12, 4049, 16, 53, 13, 17, 9444, 3]}, "items": [{"id": "p_2350", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_2351", "content": "K [SEP] aneous transport of Na+, we studied the response of cardiac (Na,K)-ATPase to NO-deficient hypertension induced in rats by NO-synt", "tokenized_content": [2, 53, 3, 9860, 2080, 4860, 1927, 4049, 15, 16, 2038, 3942, 1920, 2644, 1927, 4435, 12, 4049, 16, 53, 13, 17, 9444, 1942, 2239, 17, 5778, 5579, 2719, 1922, 3615, 3]}, "items": [{"id": "p_2351", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_2352", "content": "N(G)-nitro-L-arginine methyl ester [SEP] ion induced in rats by NO-synthase inhibition with 40 mg/kg/day N(G)-nitro-L-arginine methyl ester (L-NAME) for 4 four weeks. After 4-week administration of L-NAM", "tokenized_content": [2, 56, 12, 49, 13, 17, 8686, 17, 54, 17, 9732, 4963, 9603, 3, 4755, 2719, 1922, 3615, 2007, 2239, 17, 8921, 3523, 1956, 3040, 2786, 19, 3621, 19, 3007, 56, 3]}, "items": [{"id": "p_2352", "content": "NG-Nitroarginine Methyl Ester [SEP] A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4375, 17, 8686, 22117, 2053, 4963, 9603, 3, 43, 2447, 17, 5328, 4106, 1927, 10233, 7491, 8921, 18, 2176, 2258, 2252, 2251, 9568, 1942, 4769, 5579, 18, 3]}]}
{"query": {"id": "q_2353", "content": "L-NAME [SEP] nhibition with 40 mg/kg/day N(G)-nitro-L-arginine methyl ester (L-NAME) for 4 four weeks. After 4-week administration of L-NAME, the s", "tokenized_content": [2, 54, 17, 9533, 3, 5331, 2023, 2092, 1956, 3040, 2786, 19, 3621, 19, 3007, 56, 12, 49, 13, 17, 8686, 17, 54, 17, 9732, 4963, 9603, 12, 54, 17, 9533, 3]}, "items": [{"id": "p_2353", "content": "NG-Nitroarginine Methyl Ester [SEP] A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4375, 17, 8686, 22117, 2053, 4963, 9603, 3, 43, 2447, 17, 5328, 4106, 1927, 10233, 7491, 8921, 18, 2176, 2258, 2252, 2251, 9568, 1942, 4769, 5579, 18, 3]}]}
{"query": {"id": "q_2354", "content": "ATP [SEP] ous transport of Na+, we studied the response of cardiac (Na,K)-ATPase to NO-deficient hypertension induced in rats by NO-synthase ", "tokenized_content": [2, 4498, 3, 17208, 1036, 4860, 1927, 4049, 15, 16, 2038, 3942, 1920, 2644, 1927, 4435, 12, 4049, 16, 53, 13, 17, 9444, 1942, 2239, 17, 5778, 5579, 2719, 1922, 3615, 3]}, "items": [{"id": "p_2354", "content": "Adenosine Triphosphate [SEP] An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in meta", "score": 1, "type": null, "tokenized_content": [2, 10125, 17978, 3, 1925, 15643, 5489, 3165, 2559, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 18, 1922, 2459, 1942, 2496, 6608, 5456, 1922, 5880, 3]}]}
{"query": {"id": "q_2355", "content": "depressed [SEP] of NO-synthase induced a reversible hypertension accompanied by depressed Na+-extrusion from cardiac cells as a consequence of deteriorat", "tokenized_content": [2, 11365, 3, 1927, 2239, 17, 8921, 2719, 43, 10743, 5579, 7936, 2007, 11365, 4049, 15, 17, 20923, 2037, 4435, 2094, 1966, 43, 7749, 1927, 10901, 1926, 3]}, "items": [{"id": "p_2355", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_2356", "content": "isoproterenol [SEP] Effects of long-term pretreatment with isoproterenol on bromocriptine-induced tachycardia in conscious rats.", "tokenized_content": [2, 23743, 3, 2564, 1927, 2815, 17, 2576, 9111, 1956, 23743, 1990, 21392, 4093, 2053, 17, 2719, 17397, 1922, 11993, 3615, 18, 3]}, "items": [{"id": "p_2356", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_2357", "content": "bromocriptine [SEP] Effects of long-term pretreatment with isoproterenol on bromocriptine-induced tachycardia in conscious rats.", "tokenized_content": [2, 21392, 4093, 2053, 3, 2564, 1927, 2815, 17, 2576, 9111, 1956, 23743, 1990, 21392, 4093, 2053, 17, 2719, 17397, 1922, 11993, 3615, 18, 3]}, "items": [{"id": "p_2357", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_2358", "content": "tachycardia [SEP] g-term pretreatment with isoproterenol on bromocriptine-induced tachycardia in conscious rats.", "tokenized_content": [2, 17397, 3, 49, 17, 2576, 9111, 1956, 23743, 1990, 21392, 4093, 2053, 17, 2719, 17397, 1922, 11993, 3615, 18, 3]}, "items": [{"id": "p_2358", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_2359", "content": "bromocriptine [SEP] It has been shown that bromocriptine-induced tachycardia, which persisted after adrenalectomy, is (i", "tokenized_content": [2, 21392, 4093, 2053, 3, 2176, 2258, 2252, 2522, 1988, 21392, 4093, 2053, 17, 2719, 17397, 16, 2154, 14583, 2256, 10651, 5653, 16, 1977, 12, 51, 3]}, "items": [{"id": "p_2359", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_2360", "content": "tachycardia [SEP] It has been shown that bromocriptine-induced tachycardia, which persisted after adrenalectomy, is (i) mediated by centra", "tokenized_content": [2, 17397, 3, 2176, 2258, 2252, 2522, 1988, 21392, 4093, 2053, 17, 2719, 17397, 16, 2154, 14583, 2256, 10651, 5653, 16, 1977, 12, 51, 13, 3434, 2007, 3329, 1019, 3]}, "items": [{"id": "p_2360", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_2361", "content": "dopamine [SEP] which persisted after adrenalectomy, is (i) mediated by central dopamine D2 receptor activation and (ii) reduced by 5-day isoproterenol ", "tokenized_content": [2, 7964, 3, 2154, 14583, 2256, 10651, 5653, 16, 1977, 12, 51, 13, 3434, 2007, 4101, 7964, 8631, 3148, 2936, 1930, 12, 2890, 13, 3028, 2007, 25, 17, 3007, 23743, 3]}, "items": [{"id": "p_2361", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2362", "content": "isoproterenol [SEP] ntral dopamine D2 receptor activation and (ii) reduced by 5-day isoproterenol pretreatment, supporting therefore the hypothesis that this eff", "tokenized_content": [2, 23743, 3, 20517, 1923, 7964, 8631, 3148, 2936, 1930, 12, 2890, 13, 3028, 2007, 25, 17, 3007, 23743, 9111, 16, 6184, 2955, 1920, 4676, 1988, 2052, 2121, 3]}, "items": [{"id": "p_2362", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_2363", "content": "Isoproterenol [SEP] ld abolish bromocriptine-induced tachycardia in conscious rats. Isoproterenol pretreatment for 15 days caused cardiac hypertrophy without aff", "tokenized_content": [2, 23743, 3, 5091, 18741, 21392, 4093, 2053, 17, 2719, 17397, 1922, 11993, 3615, 18, 23743, 9111, 1958, 2461, 3000, 4189, 4435, 11014, 2979, 2633, 3]}, "items": [{"id": "p_2363", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_2364", "content": "cardiac hypertrophy [SEP] n conscious rats. Isoproterenol pretreatment for 15 days caused cardiac hypertrophy without affecting baseline blood pressure and heart rate. In co", "tokenized_content": [2, 4435, 11014, 3, 56, 11993, 3615, 18, 23743, 9111, 1958, 2461, 3000, 4189, 4435, 11014, 2979, 7359, 3703, 2877, 3772, 1930, 4003, 2769, 18, 1922, 2081, 3]}, "items": [{"id": "p_2364", "content": "Cardiomegaly [SEP] Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the l", "score": 1, "type": null, "tokenized_content": [2, 21129, 3870, 5411, 1012, 3, 16363, 1927, 1920, 4003, 16, 5394, 3391, 2007, 43, 21129, 1963, 18871, 3400, 3538, 20, 18, 2761, 18, 4003, 16363, 2278, 8156, 1920, 3659, 16, 1920, 54, 3]}]}
{"query": {"id": "q_2365", "content": "hypotension [SEP] , intravenous bromocriptine (150 microg/kg) induced significant hypotension and tachycardia. Bromocriptine-induced hypotension was unaffect", "tokenized_content": [2, 16453, 3, 16, 7307, 21392, 4093, 2053, 12, 5493, 12517, 19, 3621, 13, 2719, 2228, 16453, 1930, 17397, 18, 21392, 4093, 2053, 17, 2719, 16453, 1982, 10325, 2089, 3]}, "items": [{"id": "p_2365", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2366", "content": "Bromocriptine [SEP] 150 microg/kg) induced significant hypotension and tachycardia. Bromocriptine-induced hypotension was unaffected by isoproterenol pretreatmen", "tokenized_content": [2, 21392, 4093, 2053, 3, 5493, 12517, 19, 3621, 13, 2719, 2228, 16453, 1930, 17397, 18, 21392, 4093, 2053, 17, 2719, 16453, 1982, 10403, 2007, 23743, 24532, 1936, 1926, 19047, 3]}, "items": [{"id": "p_2366", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_2367", "content": "bradycardia [SEP] nol pretreatment, while tachycardia was reversed to significant bradycardia, an effect that was partly reduced by i.v. domperidone (0.5 mg/", "tokenized_content": [2, 26192, 3, 2239, 1024, 9111, 16, 2679, 17397, 1982, 9432, 1942, 2228, 26192, 16, 1925, 2495, 1988, 1982, 10028, 3028, 2007, 51, 18, 64, 18, 2804, 25086, 12, 20, 18, 3]}, "items": [{"id": "p_2367", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2368", "content": "domperidone [SEP] nificant bradycardia, an effect that was partly reduced by i.v. domperidone (0.5 mg/kg). Neither cardiac vagal nor sympathetic tone was alt", "tokenized_content": [2, 2804, 25086, 3, 17719, 13611, 1031, 26192, 16, 1925, 2495, 1988, 1982, 10028, 3028, 2007, 51, 18, 64, 18, 2804, 25086, 12, 20, 18, 25, 2786, 19, 3621, 13, 18, 3]}, "items": [{"id": "p_2368", "content": "Domperidone [SEP] A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antie", "score": 1, "type": null, "tokenized_content": [2, 2804, 25086, 3, 43, 2487, 14580, 1927, 7964, 4086, 18, 2176, 18663, 8375, 28823, 2472, 1937, 16, 5092, 18386, 4012, 16, 1930, 1977, 2251, 1966, 2246, 1021, 3]}]}
{"query": {"id": "q_2369", "content": "clonidine [SEP] A developmental analysis of clonidine's effects on cardiac rate and ultrasound production in infant r", "tokenized_content": [2, 26596, 3, 43, 5878, 2333, 1927, 26596, 11, 61, 2564, 1990, 4435, 2769, 1930, 7424, 3372, 1922, 8125, 60, 3]}, "items": [{"id": "p_2369", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_2370", "content": "clonidine [SEP]  and after administration of the alpha(2) adrenoceptor agonist, clonidine. Previous investigations have determined that, in response to c", "tokenized_content": [2, 26596, 3, 1930, 2256, 4183, 1927, 1920, 4595, 12, 22, 13, 25090, 7829, 16, 26596, 18, 2555, 7873, 2162, 3180, 1988, 16, 1922, 2644, 1942, 45, 3]}, "items": [{"id": "p_2370", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_2371", "content": "bradycardia [SEP] rn, and given that clonidine induces sympathetic withdrawal and bradycardia, we hypothesized that clonidine's developmental effects on card", "tokenized_content": [2, 26192, 3, 6364, 16, 1930, 3258, 1988, 26596, 6387, 11739, 9594, 1930, 26192, 16, 2038, 7149, 1988, 26596, 11, 61, 5878, 2564, 1990, 9429, 3]}, "items": [{"id": "p_2371", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2372", "content": "ketamine [SEP] Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by int", "tokenized_content": [2, 14049, 3, 5611, 2564, 1927, 22791, 5254, 14049, 1930, 19567, 1990, 5760, 1930, 10333, 21525, 2719, 2007, 2218, 3]}, "items": [{"id": "p_2372", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2373", "content": "lidocaine [SEP] Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsa", "tokenized_content": [2, 19567, 3, 5611, 2564, 1927, 22791, 5254, 14049, 1930, 19567, 1990, 5760, 1930, 10333, 21525, 2719, 2007, 18736, 7069, 19137, 3]}, "items": [{"id": "p_2373", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_2374", "content": "hyperalgesia [SEP] cally administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans.", "tokenized_content": [2, 21525, 3, 4567, 1012, 5254, 14049, 1930, 19567, 1990, 5760, 1930, 10333, 21525, 2719, 2007, 18736, 7069, 19156, 1922, 5209, 18, 3]}, "items": [{"id": "p_2374", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_2375", "content": "capsaicin [SEP] caine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans.", "tokenized_content": [2, 19156, 3, 23785, 2912, 1990, 5760, 1930, 10333, 21525, 2719, 2007, 18736, 7069, 19156, 1922, 5209, 18, 3]}, "items": [{"id": "p_2375", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_2376", "content": "ketamine [SEP] We have examined the effect of systemic administration of ketamine and lidocaine on brush-evoked (dynamic) pain and punctate-evoke", "tokenized_content": [2, 14049, 3, 2038, 2162, 3572, 1920, 2495, 1927, 5510, 4183, 1927, 14049, 1930, 19567, 1990, 19668, 17, 8782, 12, 5760, 13, 3594, 1930, 21659, 17, 24074, 3]}, "items": [{"id": "p_2376", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2377", "content": "lidocaine [SEP]  examined the effect of systemic administration of ketamine and lidocaine on brush-evoked (dynamic) pain and punctate-evoked (static) hyp", "tokenized_content": [2, 19567, 3, 3572, 1920, 2495, 1927, 5510, 4183, 1927, 14049, 1930, 19567, 1990, 19668, 17, 8782, 12, 5760, 13, 3594, 1930, 21659, 17, 8782, 12, 10333, 13, 2483, 3]}, "items": [{"id": "p_2377", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_2378", "content": "pain [SEP] inistration of ketamine and lidocaine on brush-evoked (dynamic) pain and punctate-evoked (static) hyperalgesia induced by capsaicin.", "tokenized_content": [2, 3594, 3, 1922, 3934, 1927, 14049, 1930, 19567, 1990, 19668, 17, 8782, 12, 5760, 13, 3594, 1930, 21659, 17, 8782, 12, 10333, 13, 21525, 2719, 2007, 19156, 18, 3]}, "items": [{"id": "p_2378", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2379", "content": "hyperalgesia [SEP] ine on brush-evoked (dynamic) pain and punctate-evoked (static) hyperalgesia induced by capsaicin. In a randomized, double-blind, placebo-co", "tokenized_content": [2, 21525, 3, 11116, 1990, 19668, 17, 8782, 12, 5760, 13, 3594, 1930, 21659, 17, 8782, 12, 10333, 13, 21525, 2719, 2007, 19156, 18, 1922, 43, 5542, 16, 4825, 17, 7109, 3]}, "items": [{"id": "p_2379", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_2380", "content": "capsaicin [SEP] amic) pain and punctate-evoked (static) hyperalgesia induced by capsaicin. In a randomized, double-blind, placebo-controlled, crossover s", "tokenized_content": [2, 19156, 3, 15665, 1030, 13, 3594, 1930, 21659, 17, 8782, 12, 10333, 13, 21525, 2719, 2007, 19156, 18, 1922, 43, 5542, 16, 4825, 17, 7109, 16, 5936, 17, 4642, 16, 3]}, "items": [{"id": "p_2380", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_2381", "content": "Capsaicin [SEP] crossover study, we studied 12 volunteers in three experiments. Capsaicin 100 micrograms was injected intradermally on the volar forearm ", "tokenized_content": [2, 19156, 3, 15845, 2161, 16, 2038, 3942, 2369, 9701, 1922, 2559, 3144, 18, 19156, 2813, 13362, 1982, 5624, 18736, 7069, 1954, 1990, 1920, 2984, 1933, 18652, 3]}, "items": [{"id": "p_2381", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_2382", "content": "Ketamine [SEP] S), and areas of brush-evoked and punctate-evoked hyperalgesia. Ketamine reduced both the area of brush-evoked and punctate-evoked hyper", "tokenized_content": [2, 14049, 3, 61, 13, 16, 1930, 3957, 1927, 19668, 17, 8782, 1930, 21659, 17, 8782, 21525, 18, 14049, 3028, 2321, 1920, 3403, 1927, 19668, 17, 8782, 1930, 21659, 17, 8782, 3]}, "items": [{"id": "p_2382", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2383", "content": "Lidocaine [SEP] lgesia significantly and it tended to reduce brush-evoked pain. Lidocaine reduced the area of punctate-evoked hyperalgesia significantly.", "tokenized_content": [2, 19567, 3, 28816, 12924, 1019, 2567, 1930, 2176, 10587, 1942, 4412, 19668, 17, 8782, 3594, 18, 19567, 3028, 1920, 3403, 1927, 21659, 17, 8782, 21525, 2567, 18, 3]}, "items": [{"id": "p_2383", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_2384", "content": "Cyclosporine [SEP] Cyclosporine and tacrolimus-associated thrombotic microangiopathy.", "tokenized_content": [2, 21002, 3, 21002, 1930, 21801, 17, 2458, 21039, 2703, 9506, 6522, 18, 3]}, "items": [{"id": "p_2384", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_2385", "content": "tacrolimus [SEP] Cyclosporine and tacrolimus-associated thrombotic microangiopathy.", "tokenized_content": [2, 21801, 3, 21002, 1930, 21801, 17, 2458, 21039, 2703, 9506, 6522, 18, 3]}, "items": [{"id": "p_2385", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_2386", "content": "thrombotic microangiopathy [SEP] Cyclosporine and tacrolimus-associated thrombotic microangiopathy.", "tokenized_content": [2, 21039, 2703, 9506, 6522, 3, 21002, 1930, 21801, 17, 2458, 21039, 2703, 9506, 6522, 18, 3]}, "items": [{"id": "p_2386", "content": "Thrombotic Microangiopathies [SEP] Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC", "score": 1, "type": null, "tokenized_content": [2, 21039, 2703, 9506, 16038, 3, 3902, 1988, 3211, 1922, 11354, 1922, 14264, 27795, 18, 1920, 2288, 2501, 8753, 3902, 2032, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3]}]}
{"query": {"id": "q_2387", "content": "thrombotic microangiopathy [SEP] The development of thrombotic microangiopathy (TMA) associated with the use of cyclosporine has been well doc", "tokenized_content": [2, 21039, 2703, 9506, 6522, 3, 1920, 2740, 1927, 21039, 2703, 9506, 6522, 12, 18391, 13, 2458, 1956, 1920, 2485, 1927, 21002, 2258, 2252, 2486, 4289, 3]}, "items": [{"id": "p_2387", "content": "Thrombotic Microangiopathies [SEP] Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC", "score": 1, "type": null, "tokenized_content": [2, 21039, 2703, 9506, 16038, 3, 3902, 1988, 3211, 1922, 11354, 1922, 14264, 27795, 18, 1920, 2288, 2501, 8753, 3902, 2032, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3]}]}
{"query": {"id": "q_2388", "content": "TMA [SEP] The development of thrombotic microangiopathy (TMA) associated with the use of cyclosporine has been well document", "tokenized_content": [2, 18391, 3, 1920, 2740, 1927, 21039, 2703, 9506, 6522, 12, 18391, 13, 2458, 1956, 1920, 2485, 1927, 21002, 2258, 2252, 2486, 5618, 3]}, "items": [{"id": "p_2388", "content": "Thrombotic Microangiopathies [SEP] Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC", "score": 1, "type": null, "tokenized_content": [2, 21039, 2703, 9506, 16038, 3, 3902, 1988, 3211, 1922, 11354, 1922, 14264, 27795, 18, 1920, 2288, 2501, 8753, 3902, 2032, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3]}]}
{"query": {"id": "q_2389", "content": "cyclosporine [SEP]  of thrombotic microangiopathy (TMA) associated with the use of cyclosporine has been well documented. Treatments have included discontinuat", "tokenized_content": [2, 21002, 3, 1927, 21039, 2703, 9506, 6522, 12, 18391, 13, 2458, 1956, 1920, 2485, 1927, 21002, 2258, 2252, 2486, 6974, 18, 4930, 2162, 3063, 9035, 12169, 1031, 3]}, "items": [{"id": "p_2389", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_2390", "content": "tacrolimus [SEP] ction and graft loss. The last decade has seen the emergence of tacrolimus as a potent immunosuppressive agent with mechanisms of action v", "tokenized_content": [2, 21801, 3, 3369, 2001, 1930, 7668, 3257, 18, 1920, 4691, 10468, 2258, 3945, 1920, 10400, 1927, 21801, 1966, 43, 6828, 12910, 5899, 1956, 3531, 1927, 4615, 64, 3]}, "items": [{"id": "p_2390", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_2391", "content": "anuria [SEP] Repeated transient anuria following losartan administration in a patient with a solitary ", "tokenized_content": [2, 1925, 8754, 3, 5116, 6809, 1925, 8754, 2894, 28393, 4183, 1922, 43, 2774, 1956, 43, 18992, 3]}, "items": [{"id": "p_2391", "content": "Anuria [SEP] Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urina", "score": 1, "type": null, "tokenized_content": [2, 1925, 8754, 3, 3905, 1927, 6960, 3337, 18, 2176, 1977, 5394, 2458, 1956, 4080, 7787, 24820, 12, 15168, 13, 10849, 16, 4080, 2826, 3674, 4058, 3]}]}
{"query": {"id": "q_2392", "content": "losartan [SEP] Repeated transient anuria following losartan administration in a patient with a solitary kidney.", "tokenized_content": [2, 28393, 3, 5116, 6809, 1925, 8754, 2894, 28393, 4183, 1922, 43, 2774, 1956, 43, 18992, 5245, 18, 3]}, "items": [{"id": "p_2392", "content": "Losartan [SEP] An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.", "score": 1, "type": null, "tokenized_content": [2, 28393, 3, 1925, 8151, 1927, 10814, 2601, 21, 3148, 1956, 16439, 2455, 2810, 1942, 1920, 3028, 3477, 1924, 2495, 1927, 10814, 2890, 18, 3]}]}
{"query": {"id": "q_2393", "content": "hypertensive [SEP] We report the case of a 70-year-old hypertensive man with a solitary kidney and chronic renal insufficiency who ", "tokenized_content": [2, 11706, 3, 2038, 3809, 1920, 3087, 1927, 43, 3895, 17, 2476, 17, 4156, 11706, 2323, 1956, 43, 18992, 5245, 1930, 3724, 4604, 14566, 2746, 3]}, "items": [{"id": "p_2393", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2394", "content": "chronic renal insufficiency [SEP] se of a 70-year-old hypertensive man with a solitary kidney and chronic renal insufficiency who developed two episodes of transient anuria after losartan a", "tokenized_content": [2, 3724, 4604, 14566, 3, 2058, 1927, 43, 3895, 17, 2476, 17, 4156, 11706, 2323, 1956, 43, 18992, 5245, 1930, 3724, 4604, 14566, 2746, 3530, 2288, 9232, 1927, 6809, 1925, 8754, 3]}, "items": [{"id": "p_2394", "content": "Renal Insufficiency, Chronic [SEP] Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is class", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 16, 3724, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1958, 2253, 2254, 2559, 3221, 18, 3724, 5245, 14566, 1977, 2921, 3]}]}
{"query": {"id": "q_2395", "content": "anuria [SEP] nic renal insufficiency who developed two episodes of transient anuria after losartan administration. He was hospitalized for a myocar", "tokenized_content": [2, 1925, 8754, 3, 11188, 4604, 14566, 2746, 3530, 2288, 9232, 1927, 6809, 1925, 8754, 2256, 28393, 4183, 18, 2234, 1982, 13123, 1958, 43, 15924, 15339, 3]}, "items": [{"id": "p_2395", "content": "Anuria [SEP] Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urina", "score": 1, "type": null, "tokenized_content": [2, 1925, 8754, 3, 3905, 1927, 6960, 3337, 18, 2176, 1977, 5394, 2458, 1956, 4080, 7787, 24820, 12, 15168, 13, 10849, 16, 4080, 2826, 3674, 4058, 3]}]}
{"query": {"id": "q_2396", "content": "losartan [SEP] ufficiency who developed two episodes of transient anuria after losartan administration. He was hospitalized for a myocardial infarction", "tokenized_content": [2, 28393, 3, 18661, 19894, 3349, 2589, 2746, 3530, 2288, 9232, 1927, 6809, 1925, 8754, 2256, 28393, 4183, 18, 2234, 1982, 13123, 1958, 43, 6497, 8358, 3]}, "items": [{"id": "p_2396", "content": "Losartan [SEP] An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.", "score": 1, "type": null, "tokenized_content": [2, 28393, 3, 1925, 8151, 1927, 10814, 2601, 21, 3148, 1956, 16439, 2455, 2810, 1942, 1920, 3028, 3477, 1924, 2495, 1927, 10814, 2890, 18, 3]}]}
{"query": {"id": "q_2397", "content": "myocardial infarction [SEP] anuria after losartan administration. He was hospitalized for a myocardial infarction with pulmonary edema, treated with high-dose diuretics. Due to ", "tokenized_content": [2, 6497, 8358, 3, 1925, 8754, 2256, 28393, 4183, 18, 2234, 1982, 13123, 1958, 43, 6497, 8358, 1956, 5352, 10144, 16, 2868, 1956, 2149, 17, 3253, 25505, 18, 2810, 1942, 3]}, "items": [{"id": "p_2397", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_2398", "content": "pulmonary edema [SEP] istration. He was hospitalized for a myocardial infarction with pulmonary edema, treated with high-dose diuretics. Due to severe systolic dysfu", "tokenized_content": [2, 5352, 10144, 3, 1977, 6003, 18, 2234, 1982, 13123, 1958, 43, 6497, 8358, 1956, 5352, 10144, 16, 2868, 1956, 2149, 17, 3253, 25505, 18, 2810, 1942, 4010, 8541, 3890, 19073, 3]}, "items": [{"id": "p_2398", "content": "Pulmonary Edema [SEP] Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary ", "score": 1, "type": null, "tokenized_content": [2, 5352, 10144, 3, 9122, 4858, 1927, 21263, 18021, 5148, 1005, 5466, 1922, 1920, 3614, 16, 1925, 10331, 1927, 43, 7433, 5030, 2573, 2014, 4770, 18, 5352, 3]}]}
{"query": {"id": "q_2399", "content": "systolic dysfunction [SEP] ulmonary edema, treated with high-dose diuretics. Due to severe systolic dysfunction losartan was prescribed. Surprisingly, the first dose of 50 mg ", "tokenized_content": [2, 8541, 5273, 3, 3570, 5053, 10144, 16, 2868, 1956, 2149, 17, 3253, 25505, 18, 2810, 1942, 4010, 8541, 5273, 28393, 1982, 9975, 18, 10091, 16, 1920, 2561, 3253, 1927, 2761, 3]}, "items": [{"id": "p_2399", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_2400", "content": "furosemide [SEP]  in a sudden anuria, which lasted eight hours despite high-dose furosemide and amine infusion. One week later, by mistake, losartan was pr", "tokenized_content": [2, 30509, 3, 1922, 43, 12446, 1925, 8754, 16, 2154, 16276, 5066, 3967, 4281, 2149, 17, 3253, 30509, 1930, 13610, 7386, 18, 2340, 2982, 3690, 16, 2007, 17244, 2934, 16, 28393, 3]}, "items": [{"id": "p_2400", "content": "Furosemide [SEP] A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFF", "score": 1, "type": null, "tokenized_content": [2, 30509, 3, 43, 19225, 1935, 17, 26265, 5482, 17, 28028, 1022, 18, 2176, 1977, 43, 26829, 1956, 5867, 4727, 1930, 3662, 4392, 1988, 1977, 2251, 1958, 10144, 1930, 3724, 4604, 7697, 2040, 3]}]}
{"query": {"id": "q_2401", "content": "amine [SEP] uria, which lasted eight hours despite high-dose furosemide and amine infusion. One week later, by mistake, losartan was prescribed a", "tokenized_content": [2, 13610, 3, 3674, 2126, 16, 2154, 16276, 5066, 3967, 4281, 2149, 17, 3253, 30509, 1930, 13610, 7386, 18, 2340, 2982, 3690, 16, 2007, 17244, 2934, 16, 28393, 1982, 9975, 43, 3]}, "items": [{"id": "p_2401", "content": "Amines [SEP] A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dic", "score": 1, "type": null, "tokenized_content": [2, 20739, 3, 43, 2210, 1927, 4300, 3595, 2037, 14880, 2007, 26276, 6805, 12467, 1958, 1920, 6201, 1036, 18, 12, 2037, 6216, 10, 2118, 12940, 1023, 11, 61, 4399, 9192, 3]}]}
{"query": {"id": "q_2402", "content": "hypotension [SEP] these two episodes, his blood pressure diminished but no severe hypotension was noted. Ultimately, an arteriography showed a 70-80% renal a", "tokenized_content": [2, 16453, 3, 2144, 2288, 9232, 16, 4167, 2877, 3772, 9597, 2308, 2239, 4010, 16453, 1982, 5040, 18, 8676, 16, 1925, 12480, 3796, 2594, 43, 3895, 17, 3729, 9, 4604, 43, 3]}, "items": [{"id": "p_2402", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2403", "content": "renal artery stenosis [SEP] tension was noted. Ultimately, an arteriography showed a 70-80% renal artery stenosis. In this patient, renal artery stenosis combined with heart fai", "tokenized_content": [2, 4604, 5511, 10407, 3, 10146, 1982, 5040, 18, 8676, 16, 1925, 12480, 3796, 2594, 43, 3895, 17, 3729, 9, 4604, 5511, 10407, 18, 1922, 2052, 2774, 16, 4604, 5511, 10407, 3]}, "items": [{"id": "p_2403", "content": "Renal Artery Obstruction [SEP] Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSI", "score": 1, "type": null, "tokenized_content": [2, 4604, 5511, 10849, 3, 21005, 2014, 10543, 1927, 1920, 4604, 5511, 2014, 9345, 18, 2176, 1977, 2810, 5394, 1942, 9824, 31, 21823, 10742, 14095, 31, 16379, 12924, 3]}]}
{"query": {"id": "q_2404", "content": "heart failure [SEP]  stenosis. In this patient, renal artery stenosis combined with heart failure and diuretic therapy certainly resulted in a strong activation ", "tokenized_content": [2, 4003, 4574, 3, 10407, 18, 1922, 2052, 2774, 16, 4604, 5511, 10407, 4252, 1956, 4003, 4574, 1930, 26829, 3181, 14547, 4306, 1922, 43, 3206, 2936, 3]}, "items": [{"id": "p_2404", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_2405", "content": "angiotensin [SEP]  therapy certainly resulted in a strong activation of the renin-angiotensin system (RAS). Under such conditions, angiotensin II receptor bl", "tokenized_content": [2, 10814, 3, 3181, 14547, 4306, 1922, 43, 3206, 2936, 1927, 1920, 16306, 17, 10814, 2433, 12, 6520, 13, 18, 2441, 2427, 2961, 16, 10814, 2890, 3148, 2266, 3]}, "items": [{"id": "p_2405", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_2406", "content": "angiotensin II [SEP] n of the renin-angiotensin system (RAS). Under such conditions, angiotensin II receptor blockade by losartan probably induced a critical fall ", "tokenized_content": [2, 10814, 2890, 3, 56, 1927, 1920, 16306, 17, 10814, 2433, 12, 6520, 13, 18, 2441, 2427, 2961, 16, 10814, 2890, 3148, 9847, 2007, 28393, 6226, 2719, 43, 4140, 6462, 3]}, "items": [{"id": "p_2406", "content": "Angiotensin II [SEP] An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino aci", "score": 1, "type": null, "tokenized_content": [2, 10814, 2890, 3, 1925, 5843, 24010, 1988, 1977, 43, 6828, 2308, 22001, 28404, 2684, 18, 2176, 1977, 4152, 2037, 10814, 51, 2256, 1920, 6025, 1927, 2288, 3835, 2000, 1033, 3]}]}
{"query": {"id": "q_2407", "content": "renovascular disease [SEP] tan can cause serious unexpected complications in patients with renovascular disease and should be used with extreme caution in this setting.", "tokenized_content": [2, 3866, 4901, 2573, 3, 10434, 2112, 3936, 7433, 9892, 5021, 1922, 2132, 1956, 3866, 4901, 2573, 1930, 3066, 1998, 2251, 1956, 9848, 12838, 1922, 2052, 4308, 18, 3]}, "items": [{"id": "p_2407", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_2408", "content": "necrotic [SEP] In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amioda", "tokenized_content": [2, 14275, 3, 1922, 3597, 6202, 1927, 2678, 4293, 2458, 6353, 1930, 14275, 2024, 7601, 2409, 23311, 17, 2719, 27880, 16, 15665, 25033, 3]}, "items": [{"id": "p_2408", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_2409", "content": "acetaminophen [SEP] dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and do", "tokenized_content": [2, 23311, 3, 2678, 4293, 2458, 6353, 1930, 14275, 2024, 7601, 2409, 23311, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 17, 2719, 3614, 5532, 1930, 2608, 3]}, "items": [{"id": "p_2409", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_2410", "content": "nephrotoxicity [SEP] apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardi", "tokenized_content": [2, 27880, 3, 6353, 1930, 14275, 2024, 7601, 2409, 23311, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 17, 2719, 3614, 5532, 1930, 12377, 17, 2719, 3215, 3]}, "items": [{"id": "p_2410", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2411", "content": "amiodarone [SEP] crotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 9442, 2002, 2024, 7601, 2409, 23311, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 17, 2719, 3614, 5532, 1930, 12377, 17, 2719, 30490, 2007, 3]}, "items": [{"id": "p_2411", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_2412", "content": "lung toxicity [SEP] during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape s", "tokenized_content": [2, 3614, 5532, 3, 2409, 23311, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 17, 2719, 3614, 5532, 1930, 12377, 17, 2719, 30490, 2007, 43, 4008, 13379, 7576, 1016, 18673, 61, 3]}, "items": [{"id": "p_2412", "content": "Lung Diseases [SEP] Pathological processes involving any part of the LUNG.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3614, 3902, 3, 6598, 4028, 5884, 2967, 3131, 1927, 1920, 3614, 18, 3]}]}
{"query": {"id": "q_2413", "content": "doxorubicin [SEP] en-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyan", "tokenized_content": [2, 12377, 3, 2066, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 17, 2719, 3614, 5532, 1930, 12377, 17, 2719, 30490, 2007, 43, 4008, 13379, 7576, 1016, 18673, 4861, 1965, 7744, 3]}, "items": [{"id": "p_2413", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2414", "content": "cardiotoxicity [SEP] icity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.", "tokenized_content": [2, 30490, 3, 25272, 3145, 16, 15665, 25033, 2830, 1021, 17, 2719, 3614, 5532, 1930, 12377, 17, 2719, 30490, 2007, 43, 4008, 13379, 7576, 1016, 18673, 4861, 1965, 7744, 10856, 7650, 3]}, "items": [{"id": "p_2414", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_2415", "content": "IH636 grape seed proanthocyanidin extract [SEP] lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.", "tokenized_content": [2, 13379, 7576, 1016, 18673, 4861, 1965, 7744, 10856, 7650, 5869, 3, 3614, 5532, 1930, 12377, 17, 2719, 30490, 2007, 43, 4008, 13379, 7576, 1016, 18673, 4861, 1965, 7744, 10856, 7650, 3]}, "items": [{"id": "p_2415", "content": "Grape Seed Proanthocyanidins [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 18673, 4861, 1965, 7744, 10856, 7650, 1036, 3, 3]}]}
{"query": {"id": "q_2416", "content": "Grape seed extract [SEP] Grape seed extract, primarily a mixture of proanthocyanidins, has been shown to mo", "tokenized_content": [2, 18673, 4861, 5869, 3, 18673, 4861, 5869, 16, 5985, 43, 5515, 1927, 1965, 7744, 10856, 7650, 1036, 16, 2258, 2252, 2522, 1942, 2661, 3]}, "items": [{"id": "p_2416", "content": "Grape Seed Proanthocyanidins [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 18673, 4861, 1965, 7744, 10856, 7650, 1036, 3, 3]}]}
{"query": {"id": "q_2417", "content": "proanthocyanidins [SEP] Grape seed extract, primarily a mixture of proanthocyanidins, has been shown to modulate a wide-range of biological, pharmac", "tokenized_content": [2, 1965, 7744, 10856, 7650, 1036, 3, 18673, 4861, 5869, 16, 5985, 43, 5515, 1927, 1965, 7744, 10856, 7650, 1036, 16, 2258, 2252, 2522, 1942, 8480, 43, 4743, 17, 3109, 1927, 3]}, "items": [{"id": "p_2417", "content": "Proanthocyanidins [SEP] Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They a", "score": 1, "type": null, "tokenized_content": [2, 1965, 7744, 10856, 7650, 1036, 3, 13351, 1930, 14160, 1927, 7732, 1928, 17, 23, 17, 2865, 5701, 12, 12519, 1921, 13204, 13, 4624, 4994, 2596, 10872, 1942, 19189, 9031, 1942, 9906, 6952, 4905, 10647, 13796, 8150, 22816, 1036, 18, 2611, 43, 3]}]}
{"query": {"id": "q_2418", "content": "IH636 grape seed proanthocyanidin extract [SEP] h are mainly cytoprotective. This study assessed the ability of IH636 grape seed proanthocyanidin extract (GSPE) to prevent acetaminophen (AAP)-induced nephrotoxicity, a", "tokenized_content": [2, 13379, 7576, 1016, 18673, 4861, 1965, 7744, 10856, 7650, 5869, 3, 50, 2032, 4994, 28567, 18, 2052, 2161, 3683, 1920, 3682, 1927, 13379, 7576, 1016, 18673, 4861, 1965, 7744, 10856, 3]}, "items": [{"id": "p_2418", "content": "Grape Seed Proanthocyanidins [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 18673, 4861, 1965, 7744, 10856, 7650, 1036, 3, 3]}]}
{"query": {"id": "q_2419", "content": "GSPE [SEP] essed the ability of IH636 grape seed proanthocyanidin extract (GSPE) to prevent acetaminophen (AAP)-induced nephrotoxicity, amiodar", "tokenized_content": [2, 5022, 9626, 3, 4023, 1919, 1920, 3682, 1927, 13379, 7576, 1016, 18673, 4861, 1965, 7744, 10856, 7650, 5869, 12, 5022, 9626, 13, 1942, 4625, 23311, 12, 24349, 13, 17, 2719, 3]}, "items": [{"id": "p_2419", "content": "Grape Seed Proanthocyanidins [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 18673, 4861, 1965, 7744, 10856, 7650, 1036, 3, 3]}]}
{"query": {"id": "q_2420", "content": "acetaminophen [SEP]  of IH636 grape seed proanthocyanidin extract (GSPE) to prevent acetaminophen (AAP)-induced nephrotoxicity, amiodarone (AMI)-induced lung tox", "tokenized_content": [2, 23311, 3, 1927, 13379, 7576, 1016, 18673, 4861, 1965, 7744, 10856, 7650, 5869, 12, 5022, 9626, 13, 1942, 4625, 23311, 12, 24349, 13, 17, 2719, 27880, 16, 15665, 25033, 2830, 3]}, "items": [{"id": "p_2420", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_2421", "content": "AAP [SEP]  seed proanthocyanidin extract (GSPE) to prevent acetaminophen (AAP)-induced nephrotoxicity, amiodarone (AMI)-induced lung toxicity", "tokenized_content": [2, 24349, 3, 4861, 1965, 7744, 10856, 7650, 5869, 12, 5022, 9626, 13, 1942, 4625, 23311, 12, 24349, 13, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 12, 15665, 13, 17, 3]}, "items": [{"id": "p_2421", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_2422", "content": "nephrotoxicity [SEP] ocyanidin extract (GSPE) to prevent acetaminophen (AAP)-induced nephrotoxicity, amiodarone (AMI)-induced lung toxicity, and doxorubicin (DOX)-", "tokenized_content": [2, 27880, 3, 5084, 12947, 7650, 5869, 12, 5022, 9626, 13, 1942, 4625, 23311, 12, 24349, 13, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 12, 15665, 13, 17, 2719, 3614, 3]}, "items": [{"id": "p_2422", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2423", "content": "amiodarone [SEP] t (GSPE) to prevent acetaminophen (AAP)-induced nephrotoxicity, amiodarone (AMI)-induced lung toxicity, and doxorubicin (DOX)-induced card", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 62, 12, 5022, 9626, 13, 1942, 4625, 23311, 12, 24349, 13, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 12, 15665, 13, 17, 2719, 3614, 3]}, "items": [{"id": "p_2423", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_2424", "content": "AMI [SEP] prevent acetaminophen (AAP)-induced nephrotoxicity, amiodarone (AMI)-induced lung toxicity, and doxorubicin (DOX)-induced cardiotox", "tokenized_content": [2, 15665, 3, 4625, 23311, 12, 24349, 13, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 12, 15665, 13, 17, 2719, 3614, 5532, 16, 1930, 12377, 12, 7169, 13, 17, 2719, 3]}, "items": [{"id": "p_2424", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_2425", "content": "lung toxicity [SEP] minophen (AAP)-induced nephrotoxicity, amiodarone (AMI)-induced lung toxicity, and doxorubicin (DOX)-induced cardiotoxicity in mice. Experime", "tokenized_content": [2, 3614, 5532, 3, 2360, 12218, 12, 24349, 13, 17, 2719, 27880, 16, 15665, 25033, 2830, 1021, 12, 15665, 13, 17, 2719, 3614, 5532, 16, 1930, 12377, 12, 7169, 13, 17, 3]}, "items": [{"id": "p_2425", "content": "Lung Diseases [SEP] Pathological processes involving any part of the LUNG.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3614, 3902, 3, 6598, 4028, 5884, 2967, 3131, 1927, 1920, 3614, 18, 3]}]}
{"query": {"id": "q_2426", "content": "doxorubicin [SEP] ced nephrotoxicity, amiodarone (AMI)-induced lung toxicity, and doxorubicin (DOX)-induced cardiotoxicity in mice. Experimental design consi", "tokenized_content": [2, 12377, 3, 19424, 27880, 16, 15665, 25033, 2830, 1021, 12, 15665, 13, 17, 2719, 3614, 5532, 16, 1930, 12377, 12, 7169, 13, 17, 2719, 30490, 1922, 2518, 18, 3599, 3036, 3]}, "items": [{"id": "p_2426", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2427", "content": "DOX [SEP] icity, amiodarone (AMI)-induced lung toxicity, and doxorubicin (DOX)-induced cardiotoxicity in mice. Experimental design consisted ", "tokenized_content": [2, 7169, 3, 25272, 3145, 16, 15665, 25033, 2830, 1021, 12, 15665, 13, 17, 2719, 3614, 5532, 16, 1930, 12377, 12, 7169, 13, 17, 2719, 30490, 1922, 2518, 18, 3599, 3036, 3]}, "items": [{"id": "p_2427", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2428", "content": "cardiotoxicity [SEP] rone (AMI)-induced lung toxicity, and doxorubicin (DOX)-induced cardiotoxicity in mice. Experimental design consisted of four groups: control ", "tokenized_content": [2, 30490, 3, 25851, 1021, 12, 15665, 13, 17, 2719, 3614, 5532, 16, 1930, 12377, 12, 7169, 13, 17, 2719, 30490, 1922, 2518, 18, 3599, 3036, 6994, 1927, 3006, 2671, 30, 3]}, "items": [{"id": "p_2428", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_2429", "content": "tissue damage [SEP] of kidney, heart and lung sections revealed moderate to massive tissue damage with a variety of morphological aberrations by all the three dr", "tokenized_content": [2, 2960, 4293, 3, 1927, 5245, 16, 4003, 1930, 3614, 4828, 3404, 5086, 1942, 12944, 2960, 4293, 1956, 43, 5386, 1927, 7060, 16303, 2007, 2136, 1920, 2559, 2324, 3]}, "items": [{"id": "p_2429", "content": "Soft Tissue Injuries [SEP] Injuries of tissue other than bone. The concept is usually general and does not customarily refer to internal organs or viscera.", "score": 1, "type": null, "tokenized_content": [2, 3793, 2960, 8209, 3, 8209, 1927, 2960, 2303, 2254, 3622, 18, 1920, 5658, 1977, 5394, 3335, 1930, 3731, 2084, 10206, 4697, 3333, 1942, 4495, 7393, 2014, 12108, 1019, 18, 3]}]}
{"query": {"id": "q_2430", "content": "necrosis [SEP] uch as, AAP, AMI and DOX induced apoptotic death in addition to necrosis in the respective organs which was very effectively blocked by ", "tokenized_content": [2, 7476, 3, 24314, 1966, 16, 24349, 16, 15665, 1930, 7169, 2719, 6353, 3539, 1922, 2459, 1942, 7476, 1922, 1920, 7025, 7393, 2154, 1982, 3345, 7098, 6923, 2007, 3]}, "items": [{"id": "p_2430", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_2431", "content": "Palpebral twitching [SEP] Palpebral twitching in a depressed adolescent on citalopram.", "tokenized_content": [2, 15771, 13495, 7317, 21596, 1941, 3, 15771, 13495, 7317, 21596, 1941, 1922, 43, 11365, 8402, 1990, 12366, 20807, 13399, 1035, 18, 3]}, "items": [{"id": "p_2431", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2432", "content": "depressed [SEP] Palpebral twitching in a depressed adolescent on citalopram.", "tokenized_content": [2, 11365, 3, 15771, 13495, 7317, 21596, 1941, 1922, 43, 11365, 8402, 1990, 12366, 20807, 13399, 1035, 18, 3]}, "items": [{"id": "p_2432", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_2433", "content": "citalopram [SEP] Palpebral twitching in a depressed adolescent on citalopram.", "tokenized_content": [2, 12366, 20807, 13399, 1035, 3, 15771, 13495, 7317, 21596, 1941, 1922, 43, 11365, 8402, 1990, 12366, 20807, 13399, 1035, 18, 3]}, "items": [{"id": "p_2433", "content": "Citalopram [SEP] A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in redu", "score": 1, "type": null, "tokenized_content": [2, 12366, 20807, 13399, 1035, 3, 43, 28028, 15895, 6299, 12407, 1988, 1977, 2340, 1927, 1920, 11153, 5047, 4472, 2251, 1966, 1925, 14183, 18, 1920, 2838, 1977, 2222, 3655, 1922, 2312, 1032, 3]}]}
{"query": {"id": "q_2434", "content": "major depression [SEP] tween 0.4% and 8.3% of children and adolescents are affected by major depression. We report a favorable response to treatment with citalopram by", "tokenized_content": [2, 3044, 4621, 3, 11951, 20, 18, 24, 9, 1930, 28, 18, 23, 9, 1927, 3069, 1930, 6464, 2032, 4218, 2007, 3044, 4621, 18, 2038, 3809, 43, 9327, 2644, 1942, 2311, 3]}, "items": [{"id": "p_2434", "content": "Depressive Disorder, Major [SEP] Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.\n  ", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 16, 3044, 3, 4961, 4621, 16905, 1922, 1920, 2755, 2306, 3047, 1930, 4378, 2007, 27013, 16, 2723, 3910, 16, 26124, 26822, 1019, 16, 1930, 18389, 18, 3]}]}
{"query": {"id": "q_2435", "content": "citalopram [SEP] or depression. We report a favorable response to treatment with citalopram by a 15-year-old boy with major depression who exhibited palpeb", "tokenized_content": [2, 12366, 20807, 13399, 1035, 3, 2014, 4621, 18, 2038, 3809, 43, 9327, 2644, 1942, 2311, 1956, 12366, 20807, 13399, 1035, 2007, 43, 2461, 17, 2476, 17, 4156, 17914, 1956, 3044, 3]}, "items": [{"id": "p_2435", "content": "Citalopram [SEP] A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in redu", "score": 1, "type": null, "tokenized_content": [2, 12366, 20807, 13399, 1035, 3, 43, 28028, 15895, 6299, 12407, 1988, 1977, 2340, 1927, 1920, 11153, 5047, 4472, 2251, 1966, 1925, 14183, 18, 1920, 2838, 1977, 2222, 3655, 1922, 2312, 1032, 3]}]}
{"query": {"id": "q_2436", "content": "palpebral twitching [SEP] lopram by a 15-year-old boy with major depression who exhibited palpebral twitching during his first 2 weeks of treatment. This may have been a sid", "tokenized_content": [2, 15771, 13495, 7317, 21596, 1941, 3, 3004, 13399, 1035, 2007, 43, 2461, 17, 2476, 17, 4156, 17914, 1956, 3044, 4621, 2746, 5065, 15771, 13495, 7317, 21596, 1941, 2409, 4167, 2561, 3]}, "items": [{"id": "p_2436", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_2437", "content": "Metamizol [SEP] Metamizol potentiates morphine antinociception but not constipation after", "tokenized_content": [2, 17432, 2061, 1945, 3, 17432, 2061, 1945, 29734, 11553, 23960, 15577, 2308, 2084, 19618, 2256, 3]}, "items": [{"id": "p_2437", "content": "Dipyrone [SEP] A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Because of ", "score": 1, "type": null, "tokenized_content": [2, 9137, 5134, 2912, 3, 43, 2838, 1988, 2258, 14501, 16, 2246, 17, 3769, 16, 1930, 2246, 18425, 3023, 3879, 18, 2176, 1977, 1920, 5227, 26265, 2010, 1927, 3835, 18425, 2053, 18, 2882, 1927, 3]}]}
{"query": {"id": "q_2438", "content": "morphine [SEP] Metamizol potentiates morphine antinociception but not constipation after chronic treatment.", "tokenized_content": [2, 11553, 3, 17432, 2061, 1945, 29734, 11553, 23960, 15577, 2308, 2084, 19618, 2256, 3724, 2311, 18, 3]}, "items": [{"id": "p_2438", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_2439", "content": "constipation [SEP] Metamizol potentiates morphine antinociception but not constipation after chronic treatment.", "tokenized_content": [2, 19618, 3, 17432, 2061, 1945, 29734, 11553, 23960, 15577, 2308, 2084, 19618, 2256, 3724, 2311, 18, 3]}, "items": [{"id": "p_2439", "content": "Constipation [SEP] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER", "score": 1, "type": null, "tokenized_content": [2, 19618, 3, 21587, 2014, 4571, 30034, 1927, 18610, 18, 2144, 3601, 2032, 2458, 1956, 43, 5386, 1927, 5092, 16, 2710, 2330, 6096, 6832, 3]}]}
{"query": {"id": "q_2440", "content": "constipating [SEP] This work evaluates the antinociceptive and constipating effects of the combination of 3.2 mg/kg s.c. morphine with 177.", "tokenized_content": [2, 19209, 2287, 3, 2052, 2778, 22494, 1920, 29927, 1930, 19209, 2287, 2564, 1927, 1920, 3921, 1927, 23, 18, 22, 2786, 19, 3621, 61, 18, 45, 18, 11553, 1956, 15514, 18, 3]}, "items": [{"id": "p_2440", "content": "Constipation [SEP] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER", "score": 1, "type": null, "tokenized_content": [2, 19618, 3, 21587, 2014, 4571, 30034, 1927, 18610, 18, 2144, 3601, 2032, 2458, 1956, 43, 5386, 1927, 5092, 16, 2710, 2330, 6096, 6832, 3]}]}
{"query": {"id": "q_2441", "content": "morphine [SEP] e and constipating effects of the combination of 3.2 mg/kg s.c. morphine with 177.8 mg/kg s.c. metamizol in acutely and chronically trea", "tokenized_content": [2, 11553, 3, 47, 1930, 19209, 2287, 2564, 1927, 1920, 3921, 1927, 23, 18, 22, 2786, 19, 3621, 61, 18, 45, 18, 11553, 1956, 15514, 18, 28, 2786, 19, 3621, 61, 3]}, "items": [{"id": "p_2441", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_2442", "content": "metamizol [SEP] he combination of 3.2 mg/kg s.c. morphine with 177.8 mg/kg s.c. metamizol in acutely and chronically treated (once a day for 12 days) rat", "tokenized_content": [2, 17432, 2061, 1945, 3, 2234, 3921, 1927, 23, 18, 22, 2786, 19, 3621, 61, 18, 45, 18, 11553, 1956, 15514, 18, 28, 2786, 19, 3621, 61, 18, 45, 18, 17432, 3]}, "items": [{"id": "p_2442", "content": "Dipyrone [SEP] A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Because of ", "score": 1, "type": null, "tokenized_content": [2, 9137, 5134, 2912, 3, 43, 2838, 1988, 2258, 14501, 16, 2246, 17, 3769, 16, 1930, 2246, 18425, 3023, 3879, 18, 2176, 1977, 1920, 5227, 26265, 2010, 1927, 3835, 18425, 2053, 18, 2882, 1927, 3]}]}
{"query": {"id": "q_2443", "content": "pain [SEP] ffects were assessed using a model of inflammatory nociception, pain-induced functional impairment model, and the charcoal meal test", "tokenized_content": [2, 3594, 3, 10735, 2284, 1985, 3683, 2193, 43, 2322, 1927, 3769, 14551, 15577, 16, 3594, 17, 2719, 3183, 6159, 2322, 16, 1930, 1920, 27466, 11629, 2648, 3]}, "items": [{"id": "p_2443", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2444", "content": "charcoal [SEP]  nociception, pain-induced functional impairment model, and the charcoal meal test was used to evaluate the intestinal transit. Simultan", "tokenized_content": [2, 27466, 3, 14551, 15577, 16, 3594, 17, 2719, 3183, 6159, 2322, 16, 1930, 1920, 27466, 11629, 2648, 1982, 2251, 1942, 4323, 1920, 6139, 16361, 18, 5697, 1928, 3]}, "items": [{"id": "p_2444", "content": "Charcoal [SEP] An amorphous form of carbon prepared from the incomplete combustion of animal or vegetable matter, e.g., wood. The activated for", "score": 1, "type": null, "tokenized_content": [2, 27466, 3, 1925, 16745, 2386, 1927, 5056, 4649, 2037, 1920, 9876, 24823, 1927, 4027, 2014, 17627, 6537, 16, 47, 18, 49, 18, 16, 10211, 18, 1920, 4128, 1958, 3]}]}
{"query": {"id": "q_2445", "content": "naloxone [SEP] ffects of the combination were partially prevented by 3.2 mg/kg naloxone s.c. (P<0.05), suggesting the partial involvement of the opioid", "tokenized_content": [2, 21926, 3, 10735, 2284, 1927, 1920, 3921, 1985, 6426, 8715, 2007, 23, 18, 22, 2786, 19, 3621, 21926, 61, 18, 45, 18, 12, 58, 32, 20, 18, 2914, 13, 16, 3]}, "items": [{"id": "p_2445", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_2446", "content": "constipation [SEP] , suggesting that metamizol did not potentiate morphine-induced constipation. These findings show a significant interaction between morphine", "tokenized_content": [2, 19618, 3, 16, 3783, 1988, 17432, 2061, 1945, 2811, 2084, 23350, 11553, 17, 2719, 19618, 18, 2144, 3056, 2146, 43, 2228, 2835, 2192, 11553, 3]}, "items": [{"id": "p_2446", "content": "Constipation [SEP] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER", "score": 1, "type": null, "tokenized_content": [2, 19618, 3, 21587, 2014, 4571, 30034, 1927, 18610, 18, 2144, 3601, 2032, 2458, 1956, 43, 5386, 1927, 5092, 16, 2710, 2330, 6096, 6832, 3]}]}
{"query": {"id": "q_2447", "content": "chronic pain [SEP] ting that this combination could be useful for the treatment of chronic pain.", "tokenized_content": [2, 3724, 3594, 3, 12347, 1029, 1988, 2052, 3921, 2578, 1998, 4707, 1958, 1920, 2311, 1927, 3724, 3594, 18, 3]}, "items": [{"id": "p_2447", "content": "Chronic Pain [SEP] Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persi", "score": 1, "type": null, "tokenized_content": [2, 3724, 3594, 3, 3546, 1941, 15826, 1988, 20350, 1958, 2253, 2254, 43, 3855, 3221, 18, 2176, 2278, 2014, 2278, 2084, 1998, 2458, 1956, 7176, 2014, 2573, 16, 1930, 2278, 3096, 1033, 3]}]}
{"query": {"id": "q_2448", "content": "Ifosfamide [SEP] Ifosfamide encephalopathy presenting with asterixis.", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 2647, 1951, 6016, 16408, 1021, 19393, 8326, 1956, 11239, 2416, 1937, 18, 3]}, "items": [{"id": "p_2448", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_2449", "content": "encephalopathy [SEP] Ifosfamide encephalopathy presenting with asterixis.", "tokenized_content": [2, 19393, 3, 2647, 1951, 6016, 16408, 1021, 19393, 8326, 1956, 11239, 2416, 1937, 18, 3]}, "items": [{"id": "p_2449", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_2450", "content": "asterixis [SEP] Ifosfamide encephalopathy presenting with asterixis.", "tokenized_content": [2, 11239, 2416, 1937, 3, 2647, 1951, 6016, 16408, 1021, 19393, 8326, 1956, 11239, 2416, 1937, 18, 3]}, "items": [{"id": "p_2450", "content": "Dyskinesias [SEP] Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underly", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 1036, 3, 4552, 28493, 8264, 2154, 5985, 4081, 1920, 18884, 16, 13717, 16, 2014, 16795, 1988, 4704, 1966, 43, 15570, 1927, 1925, 9886, 1012, 3]}]}
{"query": {"id": "q_2451", "content": "ifosfamide [SEP] CNS toxic effects of the antineoplastic agent ifosfamide (IFX) are frequent and include a variety of neurological sympto", "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 7520, 6161, 2564, 1927, 1920, 29128, 9969, 5899, 2647, 1951, 6016, 16408, 1021, 12, 2647, 1039, 13, 2032, 6439, 1930, 3951, 43, 5386, 1927, 3]}, "items": [{"id": "p_2451", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_2452", "content": "IFX [SEP] CNS toxic effects of the antineoplastic agent ifosfamide (IFX) are frequent and include a variety of neurological symptoms th", "tokenized_content": [2, 2647, 1039, 3, 7520, 6161, 2564, 1927, 1920, 29128, 9969, 5899, 2647, 1951, 6016, 16408, 1021, 12, 2647, 1039, 13, 2032, 6439, 1930, 3951, 43, 5386, 1927, 7605, 3601, 1913, 3]}, "items": [{"id": "p_2452", "content": "Ifosfamide [SEP] Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2647, 1951, 6016, 16408, 1021, 3, 20172, 15348, 1927, 17135, 2154, 1977, 3500, 1966, 1925, 28912, 5899, 1930, 1925, 12910, 5899, 18, 3]}]}
{"query": {"id": "q_2453", "content": "myoclonus [SEP] e of a 51-year-old man who developed severe, disabling negative myoclonus of the upper and lower extremities after the infusion of ifosfa", "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 47, 1927, 43, 4892, 17, 2476, 17, 4156, 2323, 2746, 3530, 4010, 16, 27606, 3136, 15924, 2223, 1916, 1957, 1927, 1920, 5199, 1930, 2826, 18884, 3]}, "items": [{"id": "p_2453", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_2454", "content": "plasmacytoma [SEP] pper and lower extremities after the infusion of ifosfamide for plasmacytoma. He was awake, revealed no changes of mental status and at rest", "tokenized_content": [2, 3582, 27932, 2954, 3, 29296, 1005, 1930, 2826, 18884, 2256, 1920, 7386, 1927, 2647, 1951, 6016, 16408, 1021, 1958, 3582, 27932, 2954, 18, 2234, 1982, 20274, 16, 3404, 2239, 2840, 3]}, "items": [{"id": "p_2454", "content": "Plasmacytoma [SEP] Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3582, 27932, 2954, 3, 2967, 10484, 16, 9968, 18992, 16, 3411, 1927, 12847, 3582, 2094, 3108, 1922, 3622, 6599, 2014, 3425, 8324, 2947, 19956, 3402, 18, 3]}]}
{"query": {"id": "q_2455", "content": "structural lesions of the brain [SEP] nance imaging and extensive laboratory studies failed to reveal structural lesions of the brain and metabolic abnormalities. An electroencephalogram showed con", "tokenized_content": [2, 4346, 4518, 1927, 1920, 3068, 3, 3529, 1972, 3755, 1930, 6475, 4542, 2351, 6617, 1942, 3157, 4346, 4518, 1927, 1920, 3068, 1930, 4487, 6754, 18, 1925, 21657, 7539, 2594, 1962, 3]}, "items": [{"id": "p_2455", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_2456", "content": "metabolic abnormalities [SEP] ry studies failed to reveal structural lesions of the brain and metabolic abnormalities. An electroencephalogram showed continuous, generalized irregul", "tokenized_content": [2, 4487, 6754, 3, 18650, 2351, 6617, 1942, 3157, 4346, 4518, 1927, 1920, 3068, 1930, 4487, 6754, 18, 1925, 21657, 7539, 2594, 4798, 16, 9612, 10137, 11056, 1024, 3]}, "items": [{"id": "p_2456", "content": "Metabolic Diseases [SEP] Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (MET", "score": 1, "type": null, "tokenized_content": [2, 4487, 3902, 3, 13459, 2576, 1958, 3902, 4189, 2007, 1925, 4552, 4487, 2585, 18, 2176, 2112, 1998, 9901, 2810, 1942, 12911, 4113, 14311, 12, 2130, 3]}]}
{"query": {"id": "q_2457", "content": "encephalopathy [SEP] ng with admixed periodic triphasic waves indicating symptomatic encephalopathy. The administration of ifosfamide was discontinued and within 1", "tokenized_content": [2, 19393, 3, 4375, 1956, 21694, 1919, 12922, 14051, 11316, 10826, 4168, 9371, 19393, 18, 1920, 4183, 1927, 2647, 1951, 6016, 16408, 1021, 1982, 16087, 1930, 2651, 21, 3]}, "items": [{"id": "p_2457", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_2458", "content": "asterixis [SEP] ministration of ifosfamide was discontinued and within 12 h the asterixis resolved completely. In the patient described, the presence of ", "tokenized_content": [2, 11239, 2416, 1937, 3, 9696, 2156, 5524, 1929, 1927, 2647, 1951, 6016, 16408, 1021, 1982, 16087, 1930, 2651, 2369, 50, 1920, 11239, 2416, 1937, 8397, 5796, 18, 1922, 1920, 2774, 3]}, "items": [{"id": "p_2458", "content": "Dyskinesias [SEP] Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underly", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 1036, 3, 4552, 28493, 8264, 2154, 5985, 4081, 1920, 18884, 16, 13717, 16, 2014, 16795, 1988, 4704, 1966, 43, 15570, 1927, 1925, 9886, 1012, 3]}]}
{"query": {"id": "q_2459", "content": "gamma-vinyl GABA [SEP] Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accu", "tokenized_content": [2, 7034, 17, 20642, 7992, 3, 2316, 17, 3724, 2330, 3253, 7034, 17, 20642, 7992, 12, 11505, 20013, 17670, 13, 7042, 9045, 17, 2719, 4041, 1922, 5607, 2280, 1032, 3]}, "items": [{"id": "p_2459", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_2460", "content": "vigabatrin [SEP] Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopami", "tokenized_content": [2, 11505, 20013, 17670, 3, 2316, 17, 3724, 2330, 3253, 7034, 17, 20642, 7992, 12, 11505, 20013, 17670, 13, 7042, 9045, 17, 2719, 4041, 1922, 5607, 19775, 19428, 7395, 3]}, "items": [{"id": "p_2460", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_2461", "content": "cocaine [SEP] Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine.", "tokenized_content": [2, 9045, 3, 2316, 17, 3724, 2330, 3253, 7034, 17, 20642, 7992, 12, 11505, 20013, 17670, 13, 7042, 9045, 17, 2719, 4041, 1922, 5607, 19775, 7964, 18, 3]}, "items": [{"id": "p_2461", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2462", "content": "dopamine [SEP] batrin) inhibits cocaine-induced increases in nucleus accumbens dopamine.", "tokenized_content": [2, 7964, 3, 11579, 5572, 13, 7042, 9045, 17, 2719, 4041, 1922, 5607, 19775, 7964, 18, 3]}, "items": [{"id": "p_2462", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2463", "content": "gamma-Vinyl GABA [SEP] RATIONALE: gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-recepto", "tokenized_content": [2, 7034, 17, 20642, 7992, 3, 13202, 30, 7034, 17, 20642, 7992, 12, 12042, 1029, 13, 12801, 5898, 7042, 7992, 17, 24376, 18, 2052, 2447, 17, 2793, 4575, 3]}, "items": [{"id": "p_2463", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_2464", "content": "GVG [SEP] RATIONALE: gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor med", "tokenized_content": [2, 12042, 1029, 3, 13202, 30, 7034, 17, 20642, 7992, 12, 12042, 1029, 13, 12801, 5898, 7042, 7992, 17, 24376, 18, 2052, 2447, 17, 3148, 2242, 3]}, "items": [{"id": "p_2464", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_2465", "content": "GABA [SEP] RATIONALE: gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-recepto", "tokenized_content": [2, 7992, 3, 13202, 30, 7034, 17, 20642, 7992, 12, 12042, 1029, 13, 12801, 5898, 7042, 7992, 17, 24376, 18, 2052, 2447, 17, 2793, 4575, 3]}, "items": [{"id": "p_2465", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_2466", "content": "substance abuse [SEP] abolism. OBJECTIVES: Given its preclinical success for treating substance abuse and the increased risk of visual field defects (VFD) associated", "tokenized_content": [2, 7311, 7764, 3, 9308, 2421, 18, 7634, 30, 3258, 2496, 10311, 3811, 1958, 8247, 7311, 7764, 1930, 1920, 2502, 2565, 1927, 3737, 3559, 6007, 12, 15691, 1007, 13, 2458, 3]}, "items": [{"id": "p_2466", "content": "Substance-Related Disorders [SEP] Disorders related to substance abuse.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7311, 17, 2712, 4414, 3, 4414, 2712, 1942, 7311, 7764, 18, 3]}]}
{"query": {"id": "q_2467", "content": "visual field defects [SEP]  success for treating substance abuse and the increased risk of visual field defects (VFD) associated with cumulative lifetime exposure, we explored", "tokenized_content": [2, 3737, 3559, 6007, 3, 3811, 1958, 8247, 7311, 7764, 1930, 1920, 2502, 2565, 1927, 3737, 3559, 6007, 12, 15691, 1007, 13, 2458, 1956, 8274, 9416, 3395, 16, 2038, 7255, 3]}, "items": [{"id": "p_2467", "content": "Eye Diseases [SEP] Diseases affecting the eye.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5723, 3902, 3, 3902, 7359, 1920, 5723, 18, 3]}]}
{"query": {"id": "q_2468", "content": "VFD [SEP] substance abuse and the increased risk of visual field defects (VFD) associated with cumulative lifetime exposure, we explored the ", "tokenized_content": [2, 15691, 1007, 3, 7311, 7764, 1930, 1920, 2502, 2565, 1927, 3737, 3559, 6007, 12, 15691, 1007, 13, 2458, 1956, 8274, 9416, 3395, 16, 2038, 7255, 1920, 3]}, "items": [{"id": "p_2468", "content": "Eye Diseases [SEP] Diseases affecting the eye.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5723, 3902, 3, 3902, 7359, 1920, 5723, 18, 3]}]}
{"query": {"id": "q_2469", "content": "cocaine [SEP] xposure, we explored the effects of sub-chronic low dose GVG on cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA). ME", "tokenized_content": [2, 9045, 3, 15930, 14660, 16, 2038, 7255, 1920, 2564, 1927, 2316, 17, 3724, 2330, 3253, 12042, 1029, 1990, 9045, 17, 2719, 4041, 1922, 5607, 19775, 12, 9853, 1030, 13, 7964, 3]}, "items": [{"id": "p_2469", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2470", "content": "dopamine [SEP] se GVG on cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA). METHODS: Using in vivo microdialysis, we compared acute e", "tokenized_content": [2, 7964, 3, 2058, 12042, 1029, 1990, 9045, 17, 2719, 4041, 1922, 5607, 19775, 12, 9853, 1030, 13, 7964, 12, 3692, 13, 18, 2860, 30, 2193, 1922, 3597, 27162, 16, 2038, 3]}, "items": [{"id": "p_2470", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2471", "content": "DA [SEP] cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA). METHODS: Using in vivo microdialysis, we compared acute expos", "tokenized_content": [2, 3692, 3, 9045, 17, 2719, 4041, 1922, 5607, 19775, 12, 9853, 1030, 13, 7964, 12, 3692, 13, 18, 2860, 30, 2193, 1922, 3597, 27162, 16, 2038, 2452, 3939, 2938, 3]}, "items": [{"id": "p_2471", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2472", "content": "bleeding [SEP] Amount of bleeding and hematoma size in the collagenase-induced intracerebral hemo", "tokenized_content": [2, 7633, 3, 4351, 1927, 7633, 1930, 18984, 3081, 1922, 1920, 18174, 17, 2719, 24152, 3243, 1037, 3]}, "items": [{"id": "p_2472", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_2473", "content": "hematoma [SEP] Amount of bleeding and hematoma size in the collagenase-induced intracerebral hemorrhage rat mo", "tokenized_content": [2, 18984, 3, 4351, 1927, 7633, 1930, 18984, 3081, 1922, 1920, 18174, 17, 2719, 24152, 10489, 3067, 2661, 3]}, "items": [{"id": "p_2473", "content": "Hematoma [SEP] A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18984, 3, 43, 4957, 1927, 2877, 7008, 1920, 2877, 7208, 18, 18984, 2112, 1998, 6579, 1922, 1925, 3090, 16, 5230, 16, 2014, 2960, 18, 3]}]}
{"query": {"id": "q_2474", "content": "intracerebral hemorrhage [SEP] Amount of bleeding and hematoma size in the collagenase-induced intracerebral hemorrhage rat model.", "tokenized_content": [2, 24152, 10489, 3, 4351, 1927, 7633, 1930, 18984, 3081, 1922, 1920, 18174, 17, 2719, 24152, 10489, 3067, 2322, 18, 3]}, "items": [{"id": "p_2474", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2475", "content": "intracerebral hemorrhage [SEP] The aggravated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated c", "tokenized_content": [2, 24152, 10489, 3, 1920, 29970, 2565, 1990, 24152, 10489, 12, 14910, 13, 1956, 4195, 2251, 1958, 5235, 2132, 3066, 1998, 4185, 45, 3]}, "items": [{"id": "p_2475", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2476", "content": "ICH [SEP] The aggravated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated carefu", "tokenized_content": [2, 14910, 3, 1920, 29970, 2565, 1990, 24152, 10489, 12, 14910, 13, 1956, 4195, 2251, 1958, 5235, 2132, 3066, 1998, 4185, 2859, 19073, 3]}, "items": [{"id": "p_2476", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2477", "content": "stroke [SEP] ated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated carefully. We therefore establishe", "tokenized_content": [2, 5235, 3, 30280, 1007, 2565, 1990, 24152, 10489, 12, 14910, 13, 1956, 4195, 2251, 1958, 5235, 2132, 3066, 1998, 4185, 10801, 18, 2038, 2955, 5389, 1021, 3]}, "items": [{"id": "p_2477", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_2478", "content": "bleeding [SEP] 014-unit, 0.070-unit, and 0.350-unit collagenase, the amount of bleeding was measured using a hemoglobin assay developed in the present ", "tokenized_content": [2, 7633, 3, 17763, 17, 5344, 16, 20, 18, 6627, 1008, 17, 5344, 16, 1930, 20, 18, 11936, 17, 5344, 18174, 16, 1920, 4351, 1927, 7633, 1982, 3045, 2193, 43, 9652, 3]}, "items": [{"id": "p_2478", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_2479", "content": "hematoma [SEP] sent study and was compared with the morphologically determined hematoma volume. The blood amounts and hematoma volumes were significant", "tokenized_content": [2, 18984, 3, 8437, 2161, 1930, 1982, 2452, 1956, 1920, 17312, 3180, 18984, 3776, 18, 1920, 2877, 6222, 1930, 18984, 8101, 1985, 2228, 3]}, "items": [{"id": "p_2479", "content": "Hematoma [SEP] A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18984, 3, 43, 4957, 1927, 2877, 7008, 1920, 2877, 7208, 18, 18984, 2112, 1998, 6579, 1922, 1925, 3090, 16, 5230, 16, 2014, 2960, 18, 3]}]}
{"query": {"id": "q_2480", "content": "heparin [SEP] H deterioration. In ICH induction using 0.014-unit collagenase, heparin enhanced the hematoma volume 3.4-fold over that seen in control", "tokenized_content": [2, 9962, 3, 50, 13318, 18, 1922, 14910, 4408, 2193, 20, 18, 17763, 17, 5344, 18174, 16, 9962, 4256, 1920, 18984, 3776, 23, 18, 24, 17, 3728, 2338, 1988, 3945, 1922, 3]}, "items": [{"id": "p_2480", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_2481", "content": "Estradiol [SEP] Estradiol reduces seizure-induced hippocampal injury in ovariectomized fe", "tokenized_content": [2, 11513, 3, 11513, 7268, 11015, 17, 2719, 7636, 4047, 1922, 26328, 2650, 3]}, "items": [{"id": "p_2481", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_2482", "content": "seizure [SEP] Estradiol reduces seizure-induced hippocampal injury in ovariectomized female but not in ", "tokenized_content": [2, 11015, 3, 11513, 7268, 11015, 17, 2719, 7636, 4047, 1922, 26328, 4232, 2308, 2084, 1922, 3]}, "items": [{"id": "p_2482", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2483", "content": "hippocampal injury [SEP] Estradiol reduces seizure-induced hippocampal injury in ovariectomized female but not in male rats.", "tokenized_content": [2, 7636, 4047, 3, 11513, 7268, 11015, 17, 2719, 7636, 4047, 1922, 26328, 4232, 2308, 2084, 1922, 4005, 3615, 18, 3]}, "items": [{"id": "p_2483", "content": "Brain Injuries [SEP] Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and ", "score": 1, "type": null, "tokenized_content": [2, 3068, 8209, 3, 3939, 1930, 3724, 12, 3365, 2222, 3068, 8209, 16, 3724, 13, 8209, 1942, 1920, 3068, 16, 2710, 1920, 6329, 21098, 16, 12079, 16, 1930, 3]}]}
{"query": {"id": "q_2484", "content": "hippocampal injury [SEP] Estrogens protect ovariectomized rats from hippocampal injury induced by kainic acid-induced status epilepticus (SE). We comp", "tokenized_content": [2, 7636, 4047, 3, 20470, 9145, 26328, 3615, 2037, 7636, 4047, 2719, 2007, 24714, 1935, 2687, 17, 2719, 3642, 16304, 1957, 12, 2058, 13, 18, 2038, 2059, 3]}, "items": [{"id": "p_2484", "content": "Brain Injuries [SEP] Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and ", "score": 1, "type": null, "tokenized_content": [2, 3068, 8209, 3, 3939, 1930, 3724, 12, 3365, 2222, 3068, 8209, 16, 3724, 13, 8209, 1942, 1920, 3068, 16, 2710, 1920, 6329, 21098, 16, 12079, 16, 1930, 3]}]}
{"query": {"id": "q_2485", "content": "kainic acid [SEP]  protect ovariectomized rats from hippocampal injury induced by kainic acid-induced status epilepticus (SE). We compared the effects of 17b", "tokenized_content": [2, 24714, 1935, 2687, 3, 9145, 26328, 3615, 2037, 7636, 4047, 2719, 2007, 24714, 1935, 2687, 17, 2719, 3642, 16304, 1957, 12, 2058, 13, 18, 2038, 2452, 1920, 2564, 1927, 2752, 3]}, "items": [{"id": "p_2485", "content": "Kainic Acid [SEP] (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digen", "score": 1, "type": null, "tokenized_content": [2, 24714, 1935, 2687, 3, 12, 20759, 17, 12, 22, 4595, 16, 23, 4666, 16, 24, 4666, 13, 13, 17, 22, 17, 15750, 17, 24, 17, 12, 21, 17, 4963, 3184, 8033, 13, 17, 23, 17, 23878, 5802, 13722, 2687, 18, 7249, 28867, 2261, 2926, 2037, 1920, 2312, 4326, 1019, 4325, 1917, 3]}]}
{"query": {"id": "q_2486", "content": "status epilepticus [SEP] zed rats from hippocampal injury induced by kainic acid-induced status epilepticus (SE). We compared the effects of 17beta-estradiol in adult male", "tokenized_content": [2, 3642, 16304, 1957, 3, 6116, 1007, 3615, 2037, 7636, 4047, 2719, 2007, 24714, 1935, 2687, 17, 2719, 3642, 16304, 1957, 12, 2058, 13, 18, 2038, 2452, 1920, 2564, 1927, 2752, 3]}, "items": [{"id": "p_2486", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_2487", "content": "SE [SEP] ampal injury induced by kainic acid-induced status epilepticus (SE). We compared the effects of 17beta-estradiol in adult male and", "tokenized_content": [2, 2058, 3, 16983, 1024, 4047, 2719, 2007, 24714, 1935, 2687, 17, 2719, 3642, 16304, 1957, 12, 2058, 13, 18, 2038, 2452, 1920, 2564, 1927, 2752, 20440, 17, 11513, 1922, 4160, 3]}, "items": [{"id": "p_2487", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_2488", "content": "17beta-estradiol [SEP] cid-induced status epilepticus (SE). We compared the effects of 17beta-estradiol in adult male and ovariectomized female rats subjected to lithi", "tokenized_content": [2, 2752, 20440, 17, 11513, 3, 18069, 17, 2719, 3642, 16304, 1957, 12, 2058, 13, 18, 2038, 2452, 1920, 2564, 1927, 2752, 20440, 17, 11513, 1922, 4160, 4005, 1930, 26328, 4232, 3]}, "items": [{"id": "p_2488", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_2489", "content": "lithium [SEP] adiol in adult male and ovariectomized female rats subjected to lithium-pilocarpine-induced SE. Rats received subcutaneous injections o", "tokenized_content": [2, 14330, 3, 2041, 11149, 1922, 4160, 4005, 1930, 26328, 4232, 3615, 6243, 1942, 14330, 17, 7547, 7095, 12184, 17, 2719, 2058, 18, 3615, 4004, 8634, 8775, 57, 3]}, "items": [{"id": "p_2489", "content": "Lithium [SEP] An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of", "score": 1, "type": null, "tokenized_content": [2, 14330, 3, 1925, 6149, 1922, 1920, 25178, 11570, 3416, 18, 2176, 2258, 1920, 11241, 17530, 2336, 16, 11241, 2529, 23, 16, 1930, 11241, 3388, 37, 26, 18, 6156, 1025, 31, 26, 18, 4922, 1027, 39, 18, 16028, 1927, 3]}]}
{"query": {"id": "q_2490", "content": "pilocarpine [SEP]  adult male and ovariectomized female rats subjected to lithium-pilocarpine-induced SE. Rats received subcutaneous injections of 17beta-est", "tokenized_content": [2, 7547, 7095, 12184, 3, 4160, 4005, 1930, 26328, 4232, 3615, 6243, 1942, 14330, 17, 7547, 7095, 12184, 17, 2719, 2058, 18, 3615, 4004, 8634, 8775, 1927, 2752, 20440, 17, 3255, 3]}, "items": [{"id": "p_2490", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_2491", "content": "silver [SEP] ng the second injection and terminated 3 h later. The extent of silver-stained CA3 and CA1 hippocampal neurons was evaluated 2 days af", "tokenized_content": [2, 11078, 3, 4375, 1920, 2812, 4107, 1930, 15565, 23, 50, 3690, 18, 1920, 5064, 1927, 11078, 17, 5193, 17958, 1930, 12961, 7636, 3558, 1982, 3747, 22, 3000, 2221, 3]}, "items": [{"id": "p_2491", "content": "Silver [SEP] Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medica", "score": 1, "type": null, "tokenized_content": [2, 11078, 3, 11078, 18, 1925, 6149, 1956, 1920, 11241, 17530, 2260, 16, 11241, 2529, 4261, 16, 1930, 11241, 3388, 9176, 18, 5783, 18, 2176, 1977, 43, 3793, 6048, 1988, 1977, 2251, 3935, 1019, 3]}]}
{"query": {"id": "q_2492", "content": "17beta-Estradiol [SEP]  CA3 and CA1 hippocampal neurons was evaluated 2 days after SE. 17beta-Estradiol did not alter the onset of first clonus in ovariectomized rats ", "tokenized_content": [2, 2752, 20440, 17, 11513, 3, 17958, 1930, 12961, 7636, 3558, 1982, 3747, 22, 3000, 2256, 2058, 18, 2752, 20440, 17, 11513, 2811, 2084, 4238, 1920, 4727, 1927, 2561, 6138, 1957, 3]}, "items": [{"id": "p_2492", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_2493", "content": "estradiol [SEP] uced status epilepticus (SE). We compared the effects of 17beta-estradiol in adult male and ovariectomized female rats subjected to lithi", "tokenized_content": [2, 11513, 3, 8577, 1919, 3642, 16304, 1957, 12, 2058, 13, 18, 2038, 2452, 1920, 2564, 1927, 2752, 20440, 17, 11513, 1922, 4160, 4005, 1930, 26328, 4232, 3615, 6243, 1942, 10945, 3]}, "items": [{"id": "p_2493", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_2494", "content": "seizure [SEP]  score. These findings suggest that the effects of estradiol on seizure threshold and damage may be altered by sex-related differences ", "tokenized_content": [2, 11015, 3, 3593, 18, 2144, 3056, 3220, 1988, 1920, 2564, 1927, 11513, 1990, 11015, 4683, 1930, 4293, 2278, 1998, 5520, 2007, 3486, 17, 2712, 2886, 3]}, "items": [{"id": "p_2494", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2495", "content": "Delirium [SEP] Delirium during clozapine treatment: incidence and associated risk facto", "tokenized_content": [2, 18166, 3, 18166, 2409, 24424, 2311, 30, 4332, 1930, 2458, 2565, 2371, 1037, 3]}, "items": [{"id": "p_2495", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_2496", "content": "clozapine [SEP] Delirium during clozapine treatment: incidence and associated risk factors.", "tokenized_content": [2, 24424, 3, 18166, 2409, 24424, 2311, 30, 4332, 1930, 2458, 2565, 2790, 18, 3]}, "items": [{"id": "p_2496", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_2497", "content": "delirium [SEP] BACKGROUND: Incidence and risk factors for delirium during clozapine treatment require further clarification. METHO", "tokenized_content": [2, 18166, 3, 3872, 30, 4332, 1930, 2565, 2790, 1958, 18166, 2409, 24424, 2311, 4350, 2520, 26465, 18, 2295, 1037, 3]}, "items": [{"id": "p_2497", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_2498", "content": "clozapine [SEP] BACKGROUND: Incidence and risk factors for delirium during clozapine treatment require further clarification. METHODS: We used compu", "tokenized_content": [2, 24424, 3, 3872, 30, 4332, 1930, 2565, 2790, 1958, 18166, 2409, 24424, 2311, 4350, 2520, 26465, 18, 2860, 30, 2038, 2251, 2059, 1032, 3]}, "items": [{"id": "p_2498", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_2499", "content": "psychiatric [SEP] DS: We used computerized pharmacy records to identify all adult psychiatric inpatients treated with clozapine (1995-96), reviewed their med", "tokenized_content": [2, 7652, 3, 4473, 30, 2038, 2251, 17206, 14429, 7123, 1942, 3512, 2136, 4160, 7652, 22261, 2868, 1956, 24424, 12, 6719, 17, 4746, 13, 16, 5487, 2310, 2242, 3]}, "items": [{"id": "p_2499", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_2500", "content": "Delirium [SEP] of 282 +/- 203 mg (3.45 +/- 2.45 mg/kg) for 18.9 +/- 16.4 days. Delirium was diagnosed in 14 (10.1 % incidence, or 1.48 cases/person-yea", "tokenized_content": [2, 18166, 3, 1927, 23162, 15, 19, 17, 16725, 2786, 12, 23, 18, 3607, 15, 19, 17, 22, 18, 3607, 2786, 19, 3621, 13, 1958, 2654, 18, 29, 15, 19, 17, 3]}, "items": [{"id": "p_2500", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_2501", "content": "Ketoconazole [SEP] Ketoconazole-induced neurologic sequelae.", "tokenized_content": [2, 21471, 12334, 6984, 3, 21471, 12334, 6984, 17, 2719, 14314, 19067, 18, 3]}, "items": [{"id": "p_2501", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_2502", "content": "neurologic sequelae [SEP] Ketoconazole-induced neurologic sequelae.", "tokenized_content": [2, 14314, 19067, 3, 21471, 12334, 6984, 17, 2719, 14314, 19067, 18, 3]}, "items": [{"id": "p_2502", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2503", "content": "weakness of extremities [SEP] A 77-y-old patient developed weakness of extremities, legs paralysis, dysarthria and tremor 1 h after ingestion of 2", "tokenized_content": [2, 12175, 1927, 18884, 3, 43, 5517, 17, 67, 17, 4156, 2774, 3530, 12175, 1927, 18884, 16, 16689, 18973, 16, 3890, 18956, 3027, 1019, 1930, 18388, 21, 50, 2256, 14195, 1927, 3]}, "items": [{"id": "p_2503", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_2504", "content": "legs paralysis [SEP] A 77-y-old patient developed weakness of extremities, legs paralysis, dysarthria and tremor 1 h after ingestion of 200 mg ketoconazo", "tokenized_content": [2, 16689, 18973, 3, 43, 5517, 17, 67, 17, 4156, 2774, 3530, 12175, 1927, 18884, 16, 16689, 18973, 16, 3890, 18956, 3027, 1019, 1930, 18388, 21, 50, 2256, 14195, 1927, 2191, 3]}, "items": [{"id": "p_2504", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_2505", "content": "dysarthria [SEP] -old patient developed weakness of extremities, legs paralysis, dysarthria and tremor 1 h after ingestion of 200 mg ketoconazole for the f", "tokenized_content": [2, 3890, 18956, 3027, 1019, 3, 17, 4156, 2774, 3530, 12175, 1927, 18884, 16, 16689, 18973, 16, 3890, 18956, 3027, 1019, 1930, 18388, 21, 50, 2256, 14195, 1927, 2191, 2786, 21471, 3]}, "items": [{"id": "p_2505", "content": "Dysarthria [SEP] Disorders of speech articulation caused by imperfect coordination of pharynx, larynx, tongue, or face muscles. This may result f", "score": 1, "type": null, "tokenized_content": [2, 3890, 18956, 3027, 1019, 3, 4414, 1927, 8560, 29706, 4189, 2007, 23344, 9478, 1927, 18421, 6907, 14272, 16, 27443, 16, 14761, 16, 2014, 6171, 7848, 18, 2052, 2278, 3211, 48, 3]}]}
{"query": {"id": "q_2506", "content": "tremor [SEP] veloped weakness of extremities, legs paralysis, dysarthria and tremor 1 h after ingestion of 200 mg ketoconazole for the first time i", "tokenized_content": [2, 18388, 3, 6217, 4907, 1007, 12175, 1927, 18884, 16, 16689, 18973, 16, 3890, 18956, 3027, 1019, 1930, 18388, 21, 50, 2256, 14195, 1927, 2191, 2786, 21471, 12334, 6984, 1958, 1920, 3]}, "items": [{"id": "p_2506", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_2507", "content": "ketoconazole [SEP]  paralysis, dysarthria and tremor 1 h after ingestion of 200 mg ketoconazole for the first time in his life. All complaints faded away withi", "tokenized_content": [2, 21471, 12334, 6984, 3, 18973, 16, 3890, 18956, 3027, 1019, 1930, 18388, 21, 50, 2256, 14195, 1927, 2191, 2786, 21471, 12334, 6984, 1958, 1920, 2561, 2367, 1922, 4167, 3308, 18, 3]}, "items": [{"id": "p_2507", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_2508", "content": "adverse drug reactions [SEP] e normal. This case illustrates the need for close vigilance in adverse drug reactions, particularly in the elderly.", "tokenized_content": [2, 5246, 2838, 5298, 3, 47, 2791, 18, 2052, 3087, 11897, 1920, 2942, 1958, 5428, 27097, 1922, 5246, 2838, 5298, 16, 4443, 1922, 1920, 7354, 18, 3]}, "items": [{"id": "p_2508", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2509", "content": "vascular dysfunctions [SEP] h a trigemino-parasympathetic reflex--an experimental model for vascular dysfunctions in cluster headache.", "tokenized_content": [2, 4541, 24199, 3, 50, 43, 20083, 3522, 17, 23984, 11573, 17, 17, 1925, 3599, 2322, 1958, 4541, 24199, 1922, 4377, 12187, 18, 3]}, "items": [{"id": "p_2509", "content": "Cerebrovascular Disorders [SEP] A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES; or VEINS) in the ", "score": 1, "type": null, "tokenized_content": [2, 16221, 4414, 3, 43, 5648, 1927, 6598, 2961, 1927, 5761, 2877, 3426, 1922, 1920, 3068, 18, 2611, 2112, 8156, 7208, 12, 9345, 31, 2014, 14785, 13, 1922, 1920, 3]}]}
{"query": {"id": "q_2510", "content": "cluster headache [SEP] etic reflex--an experimental model for vascular dysfunctions in cluster headache.", "tokenized_content": [2, 4377, 12187, 3, 8096, 1030, 11573, 17, 17, 1925, 3599, 2322, 1958, 4541, 24199, 1922, 4377, 12187, 18, 3]}, "items": [{"id": "p_2510", "content": "Cluster Headache [SEP] A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal o", "score": 1, "type": null, "tokenized_content": [2, 4377, 12187, 3, 43, 3065, 12187, 4770, 1988, 1977, 4378, 2007, 4010, 16, 14470, 12059, 3594, 2154, 1977, 13536, 16, 21038, 4174, 2915, 16, 5338, 57, 3]}]}
{"query": {"id": "q_2511", "content": "Cluster headache [SEP] Cluster headache is characterized by typical autonomic dysfunctions including fa", "tokenized_content": [2, 4377, 12187, 3, 4377, 12187, 1977, 4378, 2007, 5939, 13725, 24199, 2710, 5685, 3]}, "items": [{"id": "p_2511", "content": "Cluster Headache [SEP] A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal o", "score": 1, "type": null, "tokenized_content": [2, 4377, 12187, 3, 43, 3065, 12187, 4770, 1988, 1977, 4378, 2007, 4010, 16, 14470, 12059, 3594, 2154, 1977, 13536, 16, 21038, 4174, 2915, 16, 5338, 57, 3]}]}
{"query": {"id": "q_2512", "content": "intracranial vascular disturbances [SEP] cterized by typical autonomic dysfunctions including facial and intracranial vascular disturbances. Both the trigeminal and the cranial parasympathetic systems ma", "tokenized_content": [2, 12179, 4541, 12654, 3, 29486, 3027, 6756, 2007, 5939, 13725, 24199, 2710, 9567, 1930, 12179, 4541, 12654, 18, 2321, 1920, 20747, 1930, 1920, 13598, 23984, 3771, 2488, 3]}, "items": [{"id": "p_2512", "content": "Cerebrovascular Disorders [SEP] A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES; or VEINS) in the ", "score": 1, "type": null, "tokenized_content": [2, 16221, 4414, 3, 43, 5648, 1927, 6598, 2961, 1927, 5761, 2877, 3426, 1922, 1920, 3068, 18, 2611, 2112, 8156, 7208, 12, 9345, 31, 2014, 14785, 13, 1922, 1920, 3]}]}
{"query": {"id": "q_2513", "content": "Capsaicin [SEP] ra mater and the parietal cortex using laser Doppler flowmetry. Capsaicin (0.01-1 mm) applied to oral or nasal mucosa induced increases i", "tokenized_content": [2, 19156, 3, 4313, 3126, 1930, 1920, 11143, 4997, 2193, 6033, 12255, 3426, 14578, 6907, 18, 19156, 12, 20, 18, 3287, 17, 21, 2489, 13, 3730, 1942, 4726, 2014, 9305, 9680, 3]}, "items": [{"id": "p_2513", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_2514", "content": "increases in dural and cortical blood flow [SEP] . Capsaicin (0.01-1 mm) applied to oral or nasal mucosa induced increases in dural and cortical blood flow and provoked lacrimation. These responses were blocked by syste", "tokenized_content": [2, 4041, 1922, 27905, 1930, 5586, 2877, 3426, 3, 18, 19156, 12, 20, 18, 3287, 17, 21, 2489, 13, 3730, 1942, 4726, 2014, 9305, 9680, 2719, 4041, 1922, 27905, 1930, 5586, 3]}, "items": [{"id": "p_2514", "content": "Hyperemia [SEP] The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. H", "score": 1, "type": null, "tokenized_content": [2, 24004, 6026, 3, 1920, 2990, 1927, 1925, 2502, 4351, 1927, 2877, 1922, 43, 3362, 3131, 2014, 1925, 3090, 4523, 1942, 24053, 2014, 3814, 1924, 2106, 2017, 1927, 2877, 7208, 18, 50, 3]}]}
{"query": {"id": "q_2515", "content": "hexamethonium chloride [SEP]  These responses were blocked by systemic pre-administration of hexamethonium chloride (20 mg/kg). The evoked increases in dural blood flow were also ", "tokenized_content": [2, 7142, 10758, 15414, 9140, 3, 2144, 3387, 1985, 6923, 2007, 5510, 2097, 17, 4183, 1927, 7142, 10758, 15414, 9140, 12, 2036, 2786, 19, 3621, 13, 18, 1920, 8782, 4041, 1922, 3]}, "items": [{"id": "p_2515", "content": "Hexamethonium [SEP] A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gast", "score": 1, "type": null, "tokenized_content": [2, 7142, 10758, 15414, 3, 43, 20239, 13908, 8151, 3868, 6656, 1942, 1966, 1920, 29183, 12516, 1935, 14580, 18, 2176, 1977, 7865, 14504, 2037, 1920, 6215, 3]}]}
{"query": {"id": "q_2516", "content": "increases in dural blood flow [SEP] administration of hexamethonium chloride (20 mg/kg). The evoked increases in dural blood flow were also abolished by topical pre-administration of atropine (", "tokenized_content": [2, 4041, 1922, 27905, 2877, 3426, 3, 4183, 1927, 7142, 10758, 15414, 9140, 12, 2036, 2786, 19, 3621, 13, 18, 1920, 8782, 4041, 1922, 27905, 2877, 3426, 1985, 2222, 10979, 2007, 3]}, "items": [{"id": "p_2516", "content": "Hyperemia [SEP] The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. H", "score": 1, "type": null, "tokenized_content": [2, 24004, 6026, 3, 1920, 2990, 1927, 1925, 2502, 4351, 1927, 2877, 1922, 43, 3362, 3131, 2014, 1925, 3090, 4523, 1942, 24053, 2014, 3814, 1924, 2106, 2017, 1927, 2877, 7208, 18, 50, 3]}]}
{"query": {"id": "q_2517", "content": "atropine [SEP] blood flow were also abolished by topical pre-administration of atropine (1 mm) and [Lys1, Pro2,5, Arg3,4, Tyr6]-VIP (0.1 mm), a vasoact", "tokenized_content": [2, 24031, 3, 2877, 3426, 1985, 2222, 10979, 2007, 12259, 2097, 17, 4183, 1927, 24031, 12, 21, 2489, 13, 1930, 37, 3629, 1009, 16, 1965, 1028, 16, 25, 16, 4582, 1010, 3]}, "items": [{"id": "p_2517", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_2518", "content": "acetylcholine [SEP]  The blood flow responses seem to be mediated by the release of acetylcholine and VIP within the meninges. Similar mechanisms may be involved", "tokenized_content": [2, 14561, 3, 1920, 2877, 3426, 3387, 6521, 1942, 1998, 3434, 2007, 1920, 4012, 1927, 14561, 1930, 16107, 2651, 1920, 10286, 1918, 18, 2551, 3531, 2278, 1998, 3286, 3]}, "items": [{"id": "p_2518", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_2519", "content": "cluster headache [SEP] nges. Similar mechanisms may be involved in the pathogenesis of cluster headache.", "tokenized_content": [2, 4377, 12187, 3, 4375, 1918, 18, 2551, 3531, 2278, 1998, 3286, 1922, 1920, 6559, 1927, 4377, 12187, 18, 3]}, "items": [{"id": "p_2519", "content": "Cluster Headache [SEP] A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal o", "score": 1, "type": null, "tokenized_content": [2, 4377, 12187, 3, 43, 3065, 12187, 4770, 1988, 1977, 4378, 2007, 4010, 16, 14470, 12059, 3594, 2154, 1977, 13536, 16, 21038, 4174, 2915, 16, 5338, 57, 3]}]}
{"query": {"id": "q_2520", "content": "temporal lobe epilepsy [SEP] Recurrent excitation in the dentate gyrus of a murine model of temporal lobe epilepsy.", "tokenized_content": [2, 5338, 9581, 9741, 3, 7457, 8392, 1922, 1920, 17205, 10774, 1927, 43, 7135, 2322, 1927, 5338, 9581, 9741, 18, 3]}, "items": [{"id": "p_2520", "content": "Epilepsy, Temporal Lobe [SEP] A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lob", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 5338, 9581, 3, 43, 5363, 17, 2712, 12, 8083, 13, 2386, 1927, 9741, 4378, 2007, 7457, 10060, 1988, 10149, 2037, 10334, 2651, 1920, 5338, 6948, 3]}]}
{"query": {"id": "q_2521", "content": "pilocarpine [SEP] Similar to rats, systemic pilocarpine injection causes status epilepticus (SE) and the eventual devel", "tokenized_content": [2, 7547, 7095, 12184, 3, 2551, 1942, 3615, 16, 5510, 7547, 7095, 12184, 4107, 5092, 3642, 16304, 1957, 12, 2058, 13, 1930, 1920, 21199, 4251, 1938, 3]}, "items": [{"id": "p_2521", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_2522", "content": "status epilepticus [SEP] Similar to rats, systemic pilocarpine injection causes status epilepticus (SE) and the eventual development of spontaneous seizures and m", "tokenized_content": [2, 3642, 16304, 1957, 3, 2551, 1942, 3615, 16, 5510, 7547, 7095, 12184, 4107, 5092, 3642, 16304, 1957, 12, 2058, 13, 1930, 1920, 21199, 2740, 1927, 6242, 10060, 1930, 55, 3]}, "items": [{"id": "p_2522", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_2523", "content": "SE [SEP] rats, systemic pilocarpine injection causes status epilepticus (SE) and the eventual development of spontaneous seizures and mossy", "tokenized_content": [2, 2058, 3, 3615, 16, 5510, 7547, 7095, 12184, 4107, 5092, 3642, 16304, 1957, 12, 2058, 13, 1930, 1920, 21199, 2740, 1927, 6242, 10060, 1930, 18901, 1012, 3]}, "items": [{"id": "p_2523", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_2524", "content": "seizures [SEP] us epilepticus (SE) and the eventual development of spontaneous seizures and mossy fiber sprouting in C57BL/6 and CD1 mice, but the phys", "tokenized_content": [2, 10060, 3, 2022, 16304, 1957, 12, 2058, 13, 1930, 1920, 21199, 2740, 1927, 6242, 10060, 1930, 18901, 1012, 6832, 23974, 1922, 8408, 19, 26, 1930, 29218, 2518, 16, 2308, 1920, 3]}, "items": [{"id": "p_2524", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2525", "content": "Mg [SEP] ral hippocampus from pilocarpine-treated and untreated mice. In Mg(2+)-free bathing medium containing bicuculline, conditions desi", "tokenized_content": [2, 2786, 3, 15906, 7661, 2037, 7547, 7095, 12184, 17, 2868, 1930, 6829, 2518, 18, 1922, 2786, 12, 22, 15, 13, 17, 3294, 10481, 1941, 3649, 3165, 8876, 1978, 3199, 2053, 3]}, "items": [{"id": "p_2525", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_2526", "content": "bicuculline [SEP] ed and untreated mice. In Mg(2+)-free bathing medium containing bicuculline, conditions designed to increase excitability in the slices, el", "tokenized_content": [2, 8876, 1978, 3199, 2053, 3, 3347, 1930, 6829, 2518, 18, 1922, 2786, 12, 22, 15, 13, 17, 3294, 10481, 1941, 3649, 3165, 8876, 1978, 3199, 2053, 16, 2961, 4609, 1942, 3]}, "items": [{"id": "p_2526", "content": "Bicuculline [SEP] An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors", "score": 1, "type": null, "tokenized_content": [2, 8876, 1978, 3199, 2053, 3, 1925, 4911, 11072, 8419, 29951, 2926, 2037, 9192, 2334, 1019, 18242, 3199, 6148, 1930, 2303, 4793, 18, 2176, 1977, 43, 10362, 8151, 1958, 7992, 17, 43, 4086, 3]}]}
{"query": {"id": "q_2527", "content": "glutamate [SEP] discharges of 3-60 s duration, which were blocked by ionotropic glutamate receptor antagonists. Focal glutamate photostimulation of the g", "tokenized_content": [2, 7627, 3, 20805, 1927, 23, 17, 3276, 61, 4392, 16, 2154, 1985, 6923, 2007, 4755, 8405, 7627, 3148, 10515, 18, 8083, 7627, 8811, 18555, 1927, 1920, 49, 3]}, "items": [{"id": "p_2527", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_2528", "content": "seizure [SEP] us epilepticus (SE) and the eventual development of spontaneous seizures and mossy fiber sprouting in C57BL/6 and CD1 mice, but the phy", "tokenized_content": [2, 11015, 3, 2022, 16304, 1957, 12, 2058, 13, 1930, 1920, 21199, 2740, 1927, 6242, 10060, 1930, 18901, 1012, 6832, 23974, 1922, 8408, 19, 26, 1930, 29218, 2518, 16, 2308, 1920, 3]}, "items": [{"id": "p_2528", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2529", "content": "temporal lobe epilepsy [SEP] lopment in these murine strains, resembling rat models of human temporal lobe epilepsy.", "tokenized_content": [2, 5338, 9581, 9741, 3, 3004, 17922, 1939, 1922, 2144, 7135, 4046, 16, 18994, 3067, 3130, 1927, 2616, 5338, 9581, 9741, 18, 3]}, "items": [{"id": "p_2529", "content": "Epilepsy, Temporal Lobe [SEP] A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lob", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 5338, 9581, 3, 43, 5363, 17, 2712, 12, 8083, 13, 2386, 1927, 9741, 4378, 2007, 7457, 10060, 1988, 10149, 2037, 10334, 2651, 1920, 5338, 6948, 3]}]}
{"query": {"id": "q_2530", "content": "acetylcholine [SEP] The alpha3 and beta4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures a", "tokenized_content": [2, 14561, 3, 1920, 4595, 1010, 1930, 4666, 1006, 20239, 14561, 3148, 6991, 2032, 4680, 1958, 9303, 17, 2719, 10060, 43, 3]}, "items": [{"id": "p_2530", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_2531", "content": "nicotine [SEP] ta4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice.", "tokenized_content": [2, 9303, 3, 4410, 1006, 20239, 14561, 3148, 6991, 2032, 4680, 1958, 9303, 17, 2719, 10060, 1930, 14395, 6012, 13055, 13323, 1916, 1922, 2518, 18, 3]}, "items": [{"id": "p_2531", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_2532", "content": "seizures [SEP] tylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice.", "tokenized_content": [2, 10060, 3, 28483, 11603, 3148, 6991, 2032, 4680, 1958, 9303, 17, 2719, 10060, 1930, 14395, 6012, 13055, 13323, 1916, 1922, 2518, 18, 3]}, "items": [{"id": "p_2532", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2533", "content": "hypolocomotion [SEP] ceptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice.", "tokenized_content": [2, 14395, 6012, 13055, 13323, 1916, 3, 17008, 2684, 6991, 2032, 4680, 1958, 9303, 17, 2719, 10060, 1930, 14395, 6012, 13055, 13323, 1916, 1922, 2518, 18, 3]}, "items": [{"id": "p_2533", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_2534", "content": "nicotine [SEP] Binding of nicotine to nicotinic acetylcholine receptors (nAChRs) elicits a series ", "tokenized_content": [2, 9303, 3, 2743, 1927, 9303, 1942, 20239, 14561, 4086, 12, 25158, 13, 21809, 43, 4696, 3]}, "items": [{"id": "p_2534", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_2535", "content": "acetylcholine [SEP] Binding of nicotine to nicotinic acetylcholine receptors (nAChRs) elicits a series of dose-dependent behaviors", "tokenized_content": [2, 14561, 3, 2743, 1927, 9303, 1942, 20239, 14561, 4086, 12, 25158, 13, 21809, 43, 4696, 1927, 3253, 17, 3100, 5888, 3]}, "items": [{"id": "p_2535", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_2536", "content": "tremors [SEP] ndent behaviors that go from altered exploration, sedation, and tremors, to seizures and death. nAChRs are pentameric ion channels usua", "tokenized_content": [2, 18388, 1036, 3, 27594, 4905, 5888, 1988, 3611, 2037, 5520, 11557, 16, 15263, 16, 1930, 18388, 1036, 16, 1942, 10060, 1930, 3539, 18, 25158, 2032, 9412, 17118, 4755, 5628, 2022, 3]}, "items": [{"id": "p_2536", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_2537", "content": "seizures [SEP] ors that go from altered exploration, sedation, and tremors, to seizures and death. nAChRs are pentameric ion channels usually composed ", "tokenized_content": [2, 10060, 3, 14957, 1988, 3611, 2037, 5520, 11557, 16, 15263, 16, 1930, 18388, 1036, 16, 1942, 10060, 1930, 3539, 18, 25158, 2032, 9412, 17118, 4755, 5628, 5394, 7179, 3]}, "items": [{"id": "p_2537", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2538", "content": "death [SEP] rom altered exploration, sedation, and tremors, to seizures and death. nAChRs are pentameric ion channels usually composed of alpha a", "tokenized_content": [2, 3539, 3, 15612, 5520, 11557, 16, 15263, 16, 1930, 18388, 1036, 16, 1942, 10060, 1930, 3539, 18, 25158, 2032, 9412, 17118, 4755, 5628, 5394, 7179, 1927, 4595, 43, 3]}, "items": [{"id": "p_2538", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_2539", "content": "hypolocomotion [SEP] the role of the beta4 subunits in nicotine-induced seizures and hypolocomotion in beta4 homozygous null (beta4 -/-) and alpha3 heterozygous (+", "tokenized_content": [2, 14395, 6012, 13055, 13323, 1916, 3, 1920, 2770, 1927, 1920, 4666, 1006, 6991, 1922, 9303, 17, 2719, 10060, 1930, 14395, 6012, 13055, 13323, 1916, 1922, 4666, 1006, 9419, 6764, 12, 3]}, "items": [{"id": "p_2539", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_2540", "content": "interstitial nephritis [SEP] Recurrent acute interstitial nephritis induced by azithromycin.", "tokenized_content": [2, 11584, 25064, 3, 7457, 3939, 11584, 25064, 2719, 2007, 28350, 18, 3]}, "items": [{"id": "p_2540", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_2541", "content": "azithromycin [SEP] Recurrent acute interstitial nephritis induced by azithromycin.", "tokenized_content": [2, 28350, 3, 7457, 3939, 11584, 25064, 2719, 2007, 28350, 18, 3]}, "items": [{"id": "p_2541", "content": "Azithromycin [SEP] A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium a", "score": 1, "type": null, "tokenized_content": [2, 28350, 3, 43, 8762, 17, 6830, 23929, 2261, 7267, 12171, 2712, 1942, 22925, 18, 2176, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 16389, 43, 3]}]}
{"query": {"id": "q_2542", "content": "azithromycin [SEP] A 14-year-old girl is reported with recurrent, azithromycin-induced, acute interstitial nephritis. The second episode was m", "tokenized_content": [2, 28350, 3, 43, 2607, 17, 2476, 17, 4156, 21676, 1977, 2568, 1956, 7457, 16, 28350, 17, 2719, 16, 3939, 11584, 25064, 18, 1920, 2812, 11631, 1982, 55, 3]}, "items": [{"id": "p_2542", "content": "Azithromycin [SEP] A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium a", "score": 1, "type": null, "tokenized_content": [2, 28350, 3, 43, 8762, 17, 6830, 23929, 2261, 7267, 12171, 2712, 1942, 22925, 18, 2176, 2258, 2252, 2251, 1922, 1920, 2311, 1927, 16389, 43, 3]}]}
{"query": {"id": "q_2543", "content": "interstitial nephritis [SEP] ld girl is reported with recurrent, azithromycin-induced, acute interstitial nephritis. The second episode was more severe than the first; and althoug", "tokenized_content": [2, 11584, 25064, 3, 5091, 21676, 1977, 2568, 1956, 7457, 16, 28350, 17, 2719, 16, 3939, 11584, 25064, 18, 1920, 2812, 11631, 1982, 2253, 4010, 2254, 1920, 2561, 31, 1930, 2874, 3]}, "items": [{"id": "p_2543", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_2544", "content": "renal injury [SEP] enign and self-limited, some patients are at risk for permanent renal injury.", "tokenized_content": [2, 4604, 4047, 3, 2066, 2064, 1930, 3543, 17, 3892, 16, 2673, 2132, 2032, 2019, 2565, 1958, 11047, 4604, 4047, 18, 3]}, "items": [{"id": "p_2544", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2545", "content": "Valproate [SEP] Valproate-induced encephalopathy.", "tokenized_content": [2, 23867, 2010, 3, 23867, 2010, 17, 2719, 19393, 18, 3]}, "items": [{"id": "p_2545", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_2546", "content": "encephalopathy [SEP] Valproate-induced encephalopathy.", "tokenized_content": [2, 19393, 3, 23867, 2010, 17, 2719, 19393, 18, 3]}, "items": [{"id": "p_2546", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_2547", "content": "Valproate [SEP] Valproate-induced encephalopathy is a rare syndrome that may manifest in ", "tokenized_content": [2, 23867, 2010, 3, 23867, 2010, 17, 2719, 19393, 1977, 43, 5844, 4741, 1988, 2278, 7943, 1922, 3]}, "items": [{"id": "p_2547", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_2548", "content": "encephalopathy [SEP] Valproate-induced encephalopathy is a rare syndrome that may manifest in otherwise normal epilep", "tokenized_content": [2, 19393, 3, 23867, 2010, 17, 2719, 19393, 1977, 43, 5844, 4741, 1988, 2278, 7943, 1922, 7631, 2791, 7812, 1034, 3]}, "items": [{"id": "p_2548", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_2549", "content": "epileptic [SEP] opathy is a rare syndrome that may manifest in otherwise normal epileptic individuals. It may even present in patients who have tolerated", "tokenized_content": [2, 16304, 3, 20349, 28935, 1977, 43, 5844, 4741, 1988, 2278, 7943, 1922, 7631, 2791, 16304, 3445, 18, 2176, 2278, 3385, 2481, 1922, 2132, 2746, 2162, 11117, 3]}, "items": [{"id": "p_2549", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_2550", "content": "hyperammonemia [SEP]  in the past. It is usually but not necessarily associated with hyperammonemia. The EEG shows characteristic triphasic waves in most patients ", "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 1922, 1920, 5375, 18, 2176, 1977, 5394, 2308, 2084, 9409, 2458, 1956, 4194, 2595, 2290, 6026, 18, 1920, 9052, 3661, 6293, 14051, 11316, 10826, 1922, 3]}, "items": [{"id": "p_2550", "content": "Hyperammonemia [SEP] Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 4664, 2237, 1927, 14880, 1922, 1920, 2877, 18, 2176, 1977, 43, 2105, 1927, 9785, 19480, 1927, 3835, 4576, 2014, 14880, 1942, 10505, 18, 3]}]}
{"query": {"id": "q_2551", "content": "valproate [SEP] phasic waves in most patients with this complication. A case of valproate-induced encephalopathy is presented. The problems in diagnosing", "tokenized_content": [2, 23867, 2010, 3, 24328, 10826, 1922, 2501, 2132, 1956, 2052, 9388, 18, 43, 3087, 1927, 23867, 2010, 17, 2719, 19393, 1977, 3549, 18, 1920, 4951, 1922, 17555, 3]}, "items": [{"id": "p_2551", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_2552", "content": "Nitro-L-arginine methyl ester [SEP] Nitro-L-arginine methyl ester: a potential protector against gentamicin ototoxicity.", "tokenized_content": [2, 8686, 17, 54, 17, 9732, 4963, 9603, 3, 8686, 17, 54, 17, 9732, 4963, 9603, 30, 43, 2889, 9145, 1924, 3316, 17144, 7608, 11930, 18, 3]}, "items": [{"id": "p_2552", "content": "NG-Nitroarginine Methyl Ester [SEP] A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4375, 17, 8686, 22117, 2053, 4963, 9603, 3, 43, 2447, 17, 5328, 4106, 1927, 10233, 7491, 8921, 18, 2176, 2258, 2252, 2251, 9568, 1942, 4769, 5579, 18, 3]}]}
{"query": {"id": "q_2553", "content": "gentamicin [SEP] Nitro-L-arginine methyl ester: a potential protector against gentamicin ototoxicity.", "tokenized_content": [2, 17144, 3, 8686, 17, 54, 17, 9732, 4963, 9603, 30, 43, 2889, 9145, 1924, 3316, 17144, 7608, 11930, 18, 3]}, "items": [{"id": "p_2553", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_2554", "content": "ototoxicity [SEP] arginine methyl ester: a potential protector against gentamicin ototoxicity.", "tokenized_content": [2, 7608, 11930, 3, 9732, 4963, 9603, 30, 43, 2889, 9145, 1924, 3316, 17144, 7608, 11930, 18, 3]}, "items": [{"id": "p_2554", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_2555", "content": "nitric oxide [SEP] The nitric oxide (NO) inhibitor nitro-L-arginine methyl ester (L-NAME) may act a", "tokenized_content": [2, 10233, 7491, 3, 1920, 10233, 7491, 12, 2239, 13, 4106, 8686, 17, 54, 17, 9732, 4963, 9603, 12, 54, 17, 9533, 13, 2278, 4033, 43, 3]}, "items": [{"id": "p_2555", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_2556", "content": "NO [SEP] The nitric oxide (NO) inhibitor nitro-L-arginine methyl ester (L-NAME) may act as an", "tokenized_content": [2, 2239, 3, 1920, 10233, 7491, 12, 2239, 13, 4106, 8686, 17, 54, 17, 9732, 4963, 9603, 12, 54, 17, 9533, 13, 2278, 4033, 1966, 1925, 3]}, "items": [{"id": "p_2556", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_2557", "content": "nitro-L-arginine methyl ester [SEP] The nitric oxide (NO) inhibitor nitro-L-arginine methyl ester (L-NAME) may act as an otoprotectant against high-frequency hea", "tokenized_content": [2, 8686, 17, 54, 17, 9732, 4963, 9603, 3, 1920, 10233, 7491, 12, 2239, 13, 4106, 8686, 17, 54, 17, 9732, 4963, 9603, 12, 54, 17, 9533, 13, 2278, 4033, 1966, 3]}, "items": [{"id": "p_2557", "content": "NG-Nitroarginine Methyl Ester [SEP] A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4375, 17, 8686, 22117, 2053, 4963, 9603, 3, 43, 2447, 17, 5328, 4106, 1927, 10233, 7491, 8921, 18, 2176, 2258, 2252, 2251, 9568, 1942, 4769, 5579, 18, 3]}]}
{"query": {"id": "q_2558", "content": "L-NAME [SEP] The nitric oxide (NO) inhibitor nitro-L-arginine methyl ester (L-NAME) may act as an otoprotectant against high-frequency hearing los", "tokenized_content": [2, 54, 17, 9533, 3, 1920, 10233, 7491, 12, 2239, 13, 4106, 8686, 17, 54, 17, 9732, 4963, 9603, 12, 54, 17, 9533, 13, 2278, 4033, 1966, 1925, 7608, 18018, 2341, 3]}, "items": [{"id": "p_2558", "content": "NG-Nitroarginine Methyl Ester [SEP] A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4375, 17, 8686, 22117, 2053, 4963, 9603, 3, 43, 2447, 17, 5328, 4106, 1927, 10233, 7491, 8921, 18, 2176, 2258, 2252, 2251, 9568, 1942, 4769, 5579, 18, 3]}]}
{"query": {"id": "q_2559", "content": "high-frequency hearing loss [SEP] inine methyl ester (L-NAME) may act as an otoprotectant against high-frequency hearing loss caused by gentamicin, but further studies are needed to confirm", "tokenized_content": [2, 2149, 17, 3528, 8512, 3257, 3, 1922, 2053, 4963, 9603, 12, 54, 17, 9533, 13, 2278, 4033, 1966, 1925, 7608, 18018, 2341, 2031, 3316, 2149, 17, 3528, 8512, 3257, 4189, 3]}, "items": [{"id": "p_2559", "content": "Hearing Loss, High-Frequency [SEP] Hearing loss in frequencies above 1000 hertz.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 2149, 17, 3528, 3, 8512, 3257, 1922, 6458, 3538, 5672, 3656, 15982, 18, 3]}]}
{"query": {"id": "q_2560", "content": "gentamicin [SEP]  an otoprotectant against high-frequency hearing loss caused by gentamicin, but further studies are needed to confirm this.Aminoglycoside ", "tokenized_content": [2, 17144, 3, 1925, 7608, 18018, 2341, 2031, 3316, 2149, 17, 3528, 8512, 3257, 4189, 2007, 17144, 16, 2308, 2520, 2351, 2032, 4500, 1942, 4763, 2052, 18, 23029, 8028, 3]}, "items": [{"id": "p_2560", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_2561", "content": "Aminoglycoside [SEP] d by gentamicin, but further studies are needed to confirm this.Aminoglycoside antibiotics are still widely used by virtue of their efficacy a", "tokenized_content": [2, 23029, 8028, 3, 46, 2007, 17144, 16, 2308, 2520, 2351, 2032, 4500, 1942, 4763, 2052, 18, 23029, 8028, 7560, 2032, 3974, 5673, 2251, 2007, 25130, 1927, 2310, 4348, 43, 3]}, "items": [{"id": "p_2561", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_2562", "content": "ototoxicity [SEP] ill widely used by virtue of their efficacy and low cost. Their ototoxicity is a serious health problem and, as their ototoxic mechanism in", "tokenized_content": [2, 7608, 11930, 3, 3652, 5673, 2251, 2007, 25130, 1927, 2310, 4348, 1930, 2330, 4455, 18, 2310, 7608, 11930, 1977, 43, 7433, 2436, 4915, 1930, 16, 1966, 2310, 7608, 12899, 2856, 3]}, "items": [{"id": "p_2562", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_2563", "content": "ototoxic [SEP] ill widely used by virtue of their efficacy and low cost. Their ototoxicity is a serious health problem and, as their ototoxic mechanism", "tokenized_content": [2, 7608, 12899, 3, 3652, 5673, 2251, 2007, 25130, 1927, 2310, 4348, 1930, 2330, 4455, 18, 2310, 7608, 11930, 1977, 43, 7433, 2436, 4915, 1930, 16, 1966, 2310, 7608, 12899, 2856, 3]}, "items": [{"id": "p_2563", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_2564", "content": "aminoglycoside [SEP] e need to assess the use of NO inhibitors for the prevention of aminoglycoside-induced sensorineural hearing loss. In this experimental study ", "tokenized_content": [2, 23029, 8028, 3, 47, 2942, 1942, 2634, 1920, 2485, 1927, 2239, 4472, 1958, 1920, 5455, 1927, 23029, 8028, 17, 2719, 6443, 2053, 2741, 8512, 3257, 18, 1922, 2052, 3599, 2161, 3]}, "items": [{"id": "p_2564", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_2565", "content": "sensorineural hearing loss [SEP] e of NO inhibitors for the prevention of aminoglycoside-induced sensorineural hearing loss. In this experimental study we used 30 Sprague-Dawley rats, 27 ", "tokenized_content": [2, 6443, 2053, 2741, 8512, 3257, 3, 47, 1927, 2239, 4472, 1958, 1920, 5455, 1927, 23029, 8028, 17, 2719, 6443, 2053, 2741, 8512, 3257, 18, 1922, 2052, 3599, 2161, 2038, 2251, 3]}, "items": [{"id": "p_2565", "content": "Hearing Loss, Sensorineural [SEP] Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 6443, 2053, 2741, 3, 8512, 3257, 3864, 2037, 4293, 1942, 1920, 23310, 1930, 1920, 6443, 2053, 2741, 5362, 2154, 14958, 23125, 6844, 1920, 22584, 1930, 7464, 3]}]}
{"query": {"id": "q_2566", "content": "hearing loss [SEP] ter (L-NAME) may act as an otoprotectant against high-frequency hearing loss caused by gentamicin, but further studies are needed to confirm", "tokenized_content": [2, 8512, 3257, 3, 6005, 12, 54, 17, 9533, 13, 2278, 4033, 1966, 1925, 7608, 18018, 2341, 2031, 3316, 2149, 17, 3528, 8512, 3257, 4189, 2007, 17144, 16, 2308, 2520, 2351, 3]}, "items": [{"id": "p_2566", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_2567", "content": "Cerebral vasculitis [SEP] Cerebral vasculitis following oral methylphenidate intake in an adult: a case repor", "tokenized_content": [2, 6329, 21548, 3, 6329, 21548, 2894, 4726, 4963, 17616, 21550, 5240, 1922, 1925, 4160, 30, 43, 3087, 2424, 3]}, "items": [{"id": "p_2567", "content": "Vasculitis, Central Nervous System [SEP] Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathi", "score": 1, "type": null, "tokenized_content": [2, 21548, 16, 4101, 7580, 2433, 3, 4531, 1927, 2877, 7208, 2651, 1920, 4101, 7580, 2433, 18, 3065, 21548, 1977, 5394, 4189, 2007, 8904, 2014, 11407, 4290, 1033, 3]}]}
{"query": {"id": "q_2568", "content": "methylphenidate [SEP] Cerebral vasculitis following oral methylphenidate intake in an adult: a case report.", "tokenized_content": [2, 4963, 17616, 21550, 3, 6329, 21548, 2894, 4726, 4963, 17616, 21550, 5240, 1922, 1925, 4160, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_2568", "content": "Methylphenidate [SEP] A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLE", "score": 1, "type": null, "tokenized_content": [2, 4963, 17616, 21550, 3, 43, 4101, 7580, 2433, 24252, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 4976, 10506, 4770, 1922, 3069, 1930, 1958, 22872, 2456, 3]}]}
{"query": {"id": "q_2569", "content": "Methylphenidate [SEP] Methylphenidate is structurally and functionally similar to amphetamine. Cerebr", "tokenized_content": [2, 4963, 17616, 21550, 3, 4963, 17616, 21550, 1977, 12171, 1930, 9346, 2551, 1942, 19057, 18, 6626, 1005, 3]}, "items": [{"id": "p_2569", "content": "Methylphenidate [SEP] A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLE", "score": 1, "type": null, "tokenized_content": [2, 4963, 17616, 21550, 3, 43, 4101, 7580, 2433, 24252, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 4976, 10506, 4770, 1922, 3069, 1930, 1958, 22872, 2456, 3]}]}
{"query": {"id": "q_2570", "content": "amphetamine [SEP] Methylphenidate is structurally and functionally similar to amphetamine. Cerebral vasculitis associated with amphetamine abuse is well ", "tokenized_content": [2, 19057, 3, 4963, 17616, 21550, 1977, 12171, 1930, 9346, 2551, 1942, 19057, 18, 6329, 21548, 2458, 1956, 19057, 7764, 1977, 2486, 3]}, "items": [{"id": "p_2570", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_2571", "content": "Cerebral vasculitis [SEP] nidate is structurally and functionally similar to amphetamine. Cerebral vasculitis associated with amphetamine abuse is well documented, and in ra", "tokenized_content": [2, 6329, 21548, 3, 17991, 2010, 1977, 12171, 1930, 9346, 2551, 1942, 19057, 18, 6329, 21548, 2458, 1956, 19057, 7764, 1977, 2486, 6974, 16, 1930, 1922, 4313, 3]}, "items": [{"id": "p_2571", "content": "Vasculitis, Central Nervous System [SEP] Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathi", "score": 1, "type": null, "tokenized_content": [2, 21548, 16, 4101, 7580, 2433, 3, 4531, 1927, 2877, 7208, 2651, 1920, 4101, 7580, 2433, 18, 3065, 21548, 1977, 5394, 4189, 2007, 8904, 2014, 11407, 4290, 1033, 3]}]}
{"query": {"id": "q_2572", "content": "amphetamine abuse [SEP] lly similar to amphetamine. Cerebral vasculitis associated with amphetamine abuse is well documented, and in rare cases ischaemic stroke has been", "tokenized_content": [2, 19057, 7764, 3, 10748, 1012, 2551, 1942, 19057, 18, 6329, 21548, 2458, 1956, 19057, 7764, 1977, 2486, 6974, 16, 1930, 1922, 5844, 2919, 19855, 5235, 2258, 2252, 3]}, "items": [{"id": "p_2572", "content": "Amphetamine-Related Disorders [SEP] Disorders related or resulting from use of amphetamines.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19057, 17, 2712, 4414, 3, 4414, 2712, 2014, 3864, 2037, 2485, 1927, 19057, 1036, 18, 3]}]}
{"query": {"id": "q_2573", "content": "ischaemic stroke [SEP] ed with amphetamine abuse is well documented, and in rare cases ischaemic stroke has been reported after methylphenidate intake in children. We ", "tokenized_content": [2, 19855, 5235, 3, 3347, 1956, 19057, 7764, 1977, 2486, 6974, 16, 1930, 1922, 5844, 2919, 19855, 5235, 2258, 2252, 2568, 2256, 4963, 17616, 21550, 5240, 1922, 3069, 18, 2038, 3]}, "items": [{"id": "p_2573", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_2574", "content": "methylphenidate [SEP] ted, and in rare cases ischaemic stroke has been reported after methylphenidate intake in children. We report the case of a 63-year-old female ", "tokenized_content": [2, 4963, 17616, 21550, 3, 26080, 16, 1930, 1922, 5844, 2919, 19855, 5235, 2258, 2252, 2568, 2256, 4963, 17616, 21550, 5240, 1922, 3069, 18, 2038, 3809, 1920, 3087, 1927, 43, 4968, 3]}, "items": [{"id": "p_2574", "content": "Methylphenidate [SEP] A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLE", "score": 1, "type": null, "tokenized_content": [2, 4963, 17616, 21550, 3, 43, 4101, 7580, 2433, 24252, 2251, 2501, 5384, 1922, 1920, 2311, 1927, 4976, 10506, 4770, 1922, 3069, 1930, 1958, 22872, 2456, 3]}]}
{"query": {"id": "q_2575", "content": "hyperactivity [SEP]  63-year-old female who was treated with methylphenidate due to hyperactivity and suffered from multiple ischaemic strokes. We consider drug-", "tokenized_content": [2, 15534, 3, 4968, 17, 2476, 17, 4156, 4232, 2746, 1982, 2868, 1956, 4963, 17616, 21550, 2810, 1942, 15534, 1930, 13949, 2037, 3137, 19855, 21655, 18, 2038, 2782, 2838, 17, 3]}, "items": [{"id": "p_2575", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_2576", "content": "ischaemic strokes [SEP] methylphenidate due to hyperactivity and suffered from multiple ischaemic strokes. We consider drug-induced cerebral vasculitis as the most likel", "tokenized_content": [2, 19855, 21655, 3, 4963, 17616, 21550, 2810, 1942, 15534, 1930, 13949, 2037, 3137, 19855, 21655, 18, 2038, 2782, 2838, 17, 2719, 6329, 21548, 1966, 1920, 2501, 6759, 3]}, "items": [{"id": "p_2576", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_2577", "content": "cerebral vasculitis [SEP] fered from multiple ischaemic strokes. We consider drug-induced cerebral vasculitis as the most likely cause of recurrent ischaemic strokes in the ", "tokenized_content": [2, 6329, 21548, 3, 4635, 1919, 2037, 3137, 19855, 21655, 18, 2038, 2782, 2838, 17, 2719, 6329, 21548, 1966, 1920, 2501, 3205, 3936, 1927, 7457, 19855, 21655, 1922, 1920, 3]}, "items": [{"id": "p_2577", "content": "Vasculitis, Central Nervous System [SEP] Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathi", "score": 1, "type": null, "tokenized_content": [2, 21548, 16, 4101, 7580, 2433, 3, 4531, 1927, 2877, 7208, 2651, 1920, 4101, 7580, 2433, 18, 3065, 21548, 1977, 5394, 4189, 2007, 8904, 2014, 11407, 4290, 1033, 3]}]}
{"query": {"id": "q_2578", "content": "vasculitis [SEP]  structurally and functionally similar to amphetamine. Cerebral vasculitis associated with amphetamine abuse is well documented, and in ra", "tokenized_content": [2, 21548, 3, 12171, 1930, 9346, 2551, 1942, 19057, 18, 6329, 21548, 2458, 1956, 19057, 7764, 1977, 2486, 6974, 16, 1930, 1922, 4313, 3]}, "items": [{"id": "p_2578", "content": "Vasculitis [SEP] Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.\n   ", "score": 1, "type": null, "tokenized_content": [2, 21548, 3, 4531, 1927, 2967, 2340, 1927, 1920, 2877, 7208, 16, 2710, 1920, 9345, 31, 14785, 31, 1930, 6172, 1927, 1920, 13040, 2433, 1922, 1920, 3362, 18, 3]}]}
{"query": {"id": "q_2579", "content": "Cerebral haemorrhage [SEP] Cerebral haemorrhage induced by warfarin - the influence of drug-drug interactions.", "tokenized_content": [2, 6329, 23352, 3, 6329, 23352, 2719, 2007, 16170, 17, 1920, 4039, 1927, 2838, 17, 2838, 3719, 18, 3]}, "items": [{"id": "p_2579", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2580", "content": "warfarin [SEP] Cerebral haemorrhage induced by warfarin - the influence of drug-drug interactions.", "tokenized_content": [2, 16170, 3, 6329, 23352, 2719, 2007, 16170, 17, 1920, 4039, 1927, 2838, 17, 2838, 3719, 18, 3]}, "items": [{"id": "p_2580", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_2581", "content": "warfarin [SEP] POSE: To evaluate the frequency, severity and preventability of warfarin-induced cerebral haemorrhages due to warfarin and warfarin-drug", "tokenized_content": [2, 16170, 3, 15271, 30, 1942, 4323, 1920, 3528, 16, 5155, 1930, 4625, 2550, 1927, 16170, 17, 2719, 6329, 23352, 1036, 2810, 1942, 16170, 1930, 16170, 17, 2838, 3]}, "items": [{"id": "p_2581", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_2582", "content": "cerebral haemorrhages [SEP]  the frequency, severity and preventability of warfarin-induced cerebral haemorrhages due to warfarin and warfarin-drug interactions in patients livi", "tokenized_content": [2, 6329, 23352, 1036, 3, 1920, 3528, 16, 5155, 1930, 4625, 2550, 1927, 16170, 17, 2719, 6329, 23352, 1036, 2810, 1942, 16170, 1930, 16170, 17, 2838, 3719, 1922, 2132, 15260, 1033, 3]}, "items": [{"id": "p_2582", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2583", "content": "cerebral haemorrhage [SEP]  the frequency, severity and preventability of warfarin-induced cerebral haemorrhages due to warfarin and warfarin-drug interactions in patients liv", "tokenized_content": [2, 6329, 23352, 3, 1920, 3528, 16, 5155, 1930, 4625, 2550, 1927, 16170, 17, 2719, 6329, 23352, 1036, 2810, 1942, 16170, 1930, 16170, 17, 2838, 3719, 1922, 2132, 15260, 3]}, "items": [{"id": "p_2583", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_2584", "content": "haemorrhage [SEP] uency, severity and preventability of warfarin-induced cerebral haemorrhages due to warfarin and warfarin-drug interactions in patients liv", "tokenized_content": [2, 23352, 3, 63, 2589, 16, 5155, 1930, 4625, 2550, 1927, 16170, 17, 2719, 6329, 23352, 1036, 2810, 1942, 16170, 1930, 16170, 17, 2838, 3719, 1922, 2132, 15260, 3]}, "items": [{"id": "p_2584", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_2585", "content": "bleeding [SEP] n 24 (41%) of the warfarin patients and in 7 of these (12%) the bleeding complication was considered being possible to avoid. CONCLUSION", "tokenized_content": [2, 7633, 3, 56, 2686, 12, 4353, 9, 13, 1927, 1920, 16170, 2132, 1930, 1922, 27, 1927, 2144, 12, 2369, 9, 13, 1920, 7633, 9388, 1982, 3311, 3301, 3216, 1942, 5161, 3]}, "items": [{"id": "p_2585", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_2586", "content": "Warfarin [SEP] mplication was considered being possible to avoid. CONCLUSIONS: Warfarin-induced cerebral haemorrhages are a major clinical problem with", "tokenized_content": [2, 16170, 3, 26259, 2959, 1982, 3311, 3301, 3216, 1942, 5161, 18, 4355, 30, 16170, 17, 2719, 6329, 23352, 1036, 2032, 43, 3044, 2535, 4915, 1956, 3]}, "items": [{"id": "p_2586", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_2587", "content": "methylprednisolone [SEP] Side effects of postoperative administration of methylprednisolone and gentamicin into the posterior sub-Tenon's space.", "tokenized_content": [2, 30087, 3, 4159, 2564, 1927, 5924, 4183, 1927, 30087, 1930, 17144, 2460, 1920, 5545, 2316, 17, 5656, 1916, 11, 61, 5230, 18, 3]}, "items": [{"id": "p_2587", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_2588", "content": "gentamicin [SEP] fects of postoperative administration of methylprednisolone and gentamicin into the posterior sub-Tenon's space.", "tokenized_content": [2, 17144, 3, 16688, 1973, 1927, 5924, 4183, 1927, 30087, 1930, 17144, 2460, 1920, 5545, 2316, 17, 5656, 1916, 11, 61, 5230, 18, 3]}, "items": [{"id": "p_2588", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_2589", "content": "methylprednisolone [SEP] f postoperative emetic side effects after the administration of methylprednisolone and gentamicin into the posterior sub-Tenon's space at the end ", "tokenized_content": [2, 30087, 3, 48, 5924, 2391, 3023, 4159, 2564, 2256, 1920, 4183, 1927, 30087, 1930, 17144, 2460, 1920, 5545, 2316, 17, 5656, 1916, 11, 61, 5230, 2019, 1920, 2482, 3]}, "items": [{"id": "p_2589", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_2590", "content": "gentamicin [SEP] side effects after the administration of methylprednisolone and gentamicin into the posterior sub-Tenon's space at the end of routine cata", "tokenized_content": [2, 17144, 3, 4159, 2564, 2256, 1920, 4183, 1927, 30087, 1930, 17144, 2460, 1920, 5545, 2316, 17, 5656, 1916, 11, 61, 5230, 2019, 1920, 2482, 1927, 7341, 3115, 1019, 3]}, "items": [{"id": "p_2590", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_2591", "content": "cataract [SEP] icin into the posterior sub-Tenon's space at the end of routine cataract surgery. SETTING: St. Luke's Hospital, Gwardamangia, Malta. MET", "tokenized_content": [2, 14833, 3, 25272, 1022, 2460, 1920, 5545, 2316, 17, 5656, 1916, 11, 61, 5230, 2019, 1920, 2482, 1927, 7341, 14833, 3782, 18, 4308, 30, 1955, 18, 10908, 3324, 11, 61, 3]}, "items": [{"id": "p_2591", "content": "Cataract [SEP] Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many ki", "score": 1, "type": null, "tokenized_content": [2, 14833, 3, 5740, 2014, 4080, 19888, 1999, 1990, 2014, 1922, 1920, 8540, 2014, 12174, 1927, 2340, 2014, 2321, 7127, 16, 25648, 9266, 2014, 7538, 19880, 18, 1920, 3086, 8191, 3]}]}
{"query": {"id": "q_2592", "content": "lignocaine [SEP] ification under sub-Tenon's local infiltration of 3 mL of plain lignocaine. At the end of the procedure, Group A (n = 20) had 20 mg/0.5 mL", "tokenized_content": [2, 12975, 17678, 3, 29784, 11281, 2001, 2441, 2316, 17, 5656, 1916, 11, 61, 3076, 8946, 1927, 23, 2646, 1927, 16739, 12975, 17678, 18, 2019, 1920, 2482, 1927, 1920, 4360, 16, 3]}, "items": [{"id": "p_2592", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_2593", "content": "nausea, vomiting [SEP] ce. Postoperatively, all patients were assessed for symptoms of nausea, vomiting, and headache. A chi-square test was used to assess the statist", "tokenized_content": [2, 13759, 16, 13954, 3, 5827, 18, 13173, 16, 2136, 2132, 1985, 3683, 1958, 3601, 1927, 13759, 16, 13954, 16, 1930, 12187, 18, 43, 7368, 17, 6940, 2648, 1982, 2251, 1942, 3]}, "items": [{"id": "p_2593", "content": "Postoperative Nausea and Vomiting [SEP] Emesis and queasiness occurring after anesthesia.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5924, 13759, 1930, 13954, 3, 2391, 2600, 1930, 10730, 20474, 1979, 6966, 2256, 8871, 18, 3]}]}
{"query": {"id": "q_2594", "content": "headache [SEP] ll patients were assessed for symptoms of nausea, vomiting, and headache. A chi-square test was used to assess the statistical significa", "tokenized_content": [2, 12187, 3, 10748, 2132, 1985, 3683, 1958, 3601, 1927, 13759, 16, 13954, 16, 1930, 12187, 18, 43, 7368, 17, 6940, 2648, 1982, 2251, 1942, 2634, 1920, 3850, 2208, 1019, 3]}, "items": [{"id": "p_2594", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_2595", "content": "postoperative emetic symptoms [SEP] ficance of results. RESULTS: Sixty percent in Group A developed postoperative emetic symptoms, headache, or both; 1 patient in Group B developed symptoms. CO", "tokenized_content": [2, 5924, 2391, 3023, 3601, 3, 17662, 2152, 1927, 2274, 18, 2274, 30, 14063, 3564, 1922, 2210, 43, 3530, 5924, 2391, 3023, 3601, 16, 12187, 16, 2014, 2321, 31, 21, 2774, 3]}, "items": [{"id": "p_2595", "content": "Postoperative Nausea and Vomiting [SEP] Emesis and queasiness occurring after anesthesia.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5924, 13759, 1930, 13954, 3, 2391, 2600, 1930, 10730, 20474, 1979, 6966, 2256, 8871, 18, 3]}]}
{"query": {"id": "q_2596", "content": "nephropathy [SEP] ARE) study: a randomized double-blind trial of contrast-induced nephropathy in patients with chronic kidney disease.", "tokenized_content": [2, 15582, 3, 2032, 13, 2161, 30, 43, 5542, 4825, 17, 7109, 3046, 1927, 3320, 17, 2719, 15582, 1922, 2132, 1956, 3724, 5245, 2573, 18, 3]}, "items": [{"id": "p_2596", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2597", "content": "chronic kidney disease [SEP] le-blind trial of contrast-induced nephropathy in patients with chronic kidney disease.", "tokenized_content": [2, 3724, 5245, 2573, 3, 2071, 17, 7109, 3046, 1927, 3320, 17, 2719, 15582, 1922, 2132, 1956, 3724, 5245, 2573, 18, 3]}, "items": [{"id": "p_2597", "content": "Renal Insufficiency, Chronic [SEP] Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is class", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 16, 3724, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1958, 2253, 2254, 2559, 3221, 18, 3724, 5245, 14566, 1977, 2921, 3]}]}
{"query": {"id": "q_2598", "content": "contrast medium [SEP] mparisons exist of the renal tolerability of the low-osmolality contrast medium iopamidol with that of the iso-osmolality contrast medium iodix", "tokenized_content": [2, 3320, 3649, 3, 12888, 13950, 2101, 5516, 1927, 1920, 4604, 17934, 1927, 1920, 2330, 17, 28854, 3320, 3649, 12906, 25238, 1945, 1956, 1988, 1927, 1920, 4911, 17, 28854, 3320, 3649, 3]}, "items": [{"id": "p_2598", "content": "Contrast Media [SEP] Substances used to allow enhanced visualization of tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3320, 4996, 3, 10054, 2251, 1942, 3235, 4256, 9966, 1927, 3878, 18, 3]}]}
{"query": {"id": "q_2599", "content": "iopamidol [SEP] of the renal tolerability of the low-osmolality contrast medium iopamidol with that of the iso-osmolality contrast medium iodixanol in hi", "tokenized_content": [2, 12906, 25238, 1945, 3, 1927, 1920, 4604, 17934, 1927, 1920, 2330, 17, 28854, 3320, 3649, 12906, 25238, 1945, 1956, 1988, 1927, 1920, 4911, 17, 28854, 3320, 3649, 8594, 2416, 4296, 3]}, "items": [{"id": "p_2599", "content": "Iopamidol [SEP] A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and othe", "score": 1, "type": null, "tokenized_content": [2, 12906, 25238, 1945, 3, 43, 2447, 17, 11478, 16, 3224, 17, 6622, 3320, 5899, 2154, 1977, 2251, 1922, 5707, 3796, 16, 9273, 6405, 5524, 25818, 16, 7737, 1931, 9506, 3796, 16, 12480, 3796, 16, 1930, 7608, 4116, 3]}]}
{"query": {"id": "q_2600", "content": "iodixanol [SEP] edium iopamidol with that of the iso-osmolality contrast medium iodixanol in high-risk patients. METHODS AND RESULTS: The present study i", "tokenized_content": [2, 8594, 2416, 4296, 3, 3347, 2457, 12906, 25238, 1945, 1956, 1988, 1927, 1920, 4911, 17, 28854, 3320, 3649, 8594, 2416, 4296, 1922, 2149, 17, 2565, 2132, 18, 2860, 1930, 2274, 3]}, "items": [{"id": "p_2600", "content": "iodixanol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8594, 2416, 4296, 3, 3]}]}
{"query": {"id": "q_2601", "content": "chronic kidney disease [SEP] le-blind comparison of iopamidol and iodixanol in patients with chronic kidney disease (estimated glomerular filtration rate, 20 to 59 mL/min) who und", "tokenized_content": [2, 3724, 5245, 2573, 3, 2071, 17, 7109, 3723, 1927, 12906, 25238, 1945, 1930, 8594, 2416, 4296, 1922, 2132, 1956, 3724, 5245, 2573, 12, 4185, 11655, 10347, 2769, 16, 2036, 1942, 3]}, "items": [{"id": "p_2601", "content": "Renal Insufficiency, Chronic [SEP] Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is class", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 16, 3724, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1958, 2253, 2254, 2559, 3221, 18, 3724, 5245, 14566, 1977, 2921, 3]}]}
{"query": {"id": "q_2602", "content": "creatinine [SEP] rdiac angiography or percutaneous coronary interventions. Serum creatinine (SCr) levels and estimated glomerular filtration rate were asse", "tokenized_content": [2, 9374, 3, 8695, 2126, 1030, 11676, 2014, 12826, 5846, 4984, 18, 3256, 9374, 12, 7572, 13, 2428, 1930, 4185, 11655, 10347, 2769, 1985, 2088, 1021, 3]}, "items": [{"id": "p_2602", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_2603", "content": "diabetes mellitus [SEP] ak change in SCr. In 414 patients, contrast volume, presence of diabetes mellitus, use of N-acetylcysteine, mean baseline SCr, and estimated glom", "tokenized_content": [2, 4032, 9695, 3, 4464, 3185, 1922, 7572, 18, 1922, 27774, 2132, 16, 3320, 3776, 16, 2990, 1927, 4032, 9695, 16, 2485, 1927, 56, 17, 6894, 23159, 7595, 16, 2667, 3703, 3]}, "items": [{"id": "p_2603", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_2604", "content": "N-acetylcysteine [SEP] atients, contrast volume, presence of diabetes mellitus, use of N-acetylcysteine, mean baseline SCr, and estimated glomerular filtration rate we", "tokenized_content": [2, 56, 17, 6894, 23159, 7595, 3, 2019, 6746, 16, 3320, 3776, 16, 2990, 1927, 4032, 9695, 16, 2485, 1927, 56, 17, 6894, 23159, 7595, 16, 2667, 3703, 7572, 16, 1930, 3]}, "items": [{"id": "p_2604", "content": "Acetylcysteine [SEP] The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also b", "score": 1, "type": null, "tokenized_content": [2, 6894, 23159, 7595, 3, 1920, 56, 17, 6894, 10533, 1927, 8666, 18, 2176, 1977, 2251, 1966, 43, 3422, 6586, 5899, 1942, 4412, 1920, 13869, 1927, 27103, 21417, 18, 2176, 2258, 2222, 44, 3]}]}
{"query": {"id": "q_2605", "content": "diabetes [SEP] ak change in SCr. In 414 patients, contrast volume, presence of diabetes mellitus, use of N-acetylcysteine, mean baseline SCr, and estim", "tokenized_content": [2, 4032, 3, 4464, 3185, 1922, 7572, 18, 1922, 27774, 2132, 16, 3320, 3776, 16, 2990, 1927, 4032, 9695, 16, 2485, 1927, 56, 17, 6894, 23159, 7595, 16, 2667, 3703, 7572, 3]}, "items": [{"id": "p_2605", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_2606", "content": "nephropathy [SEP]  micromol/L, P=0.01). CONCLUSIONS: The rate of contrast-induced nephropathy, defined by multiple end points, is not statistically different", "tokenized_content": [2, 15582, 3, 25385, 19, 54, 16, 58, 33, 20, 18, 3287, 13, 18, 4355, 30, 1920, 2769, 1927, 3320, 17, 2719, 15582, 16, 3608, 2007, 3137, 2482, 4273, 16, 1977, 3]}, "items": [{"id": "p_2606", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2607", "content": "maltolyl p-coumarate [SEP] A novel compound, maltolyl p-coumarate, attenuates cognitive deficits and shows neuroprotective effect", "tokenized_content": [2, 15505, 26558, 1024, 58, 17, 24503, 17488, 3, 43, 4008, 3547, 16, 15505, 26558, 1024, 58, 17, 24503, 17488, 16, 18260, 4328, 7961, 1930, 3661, 14345, 2495, 3]}, "items": [{"id": "p_2607", "content": "maltolyl p-coumarate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15505, 26558, 1024, 58, 17, 24503, 17488, 3, 3]}]}
{"query": {"id": "q_2608", "content": "cognitive deficits [SEP] A novel compound, maltolyl p-coumarate, attenuates cognitive deficits and shows neuroprotective effects in vitro and in vivo dementia", "tokenized_content": [2, 4328, 7961, 3, 43, 4008, 3547, 16, 15505, 26558, 1024, 58, 17, 24503, 17488, 16, 18260, 4328, 7961, 1930, 3661, 14345, 2564, 1922, 3596, 1930, 1922, 3597, 7811, 3]}, "items": [{"id": "p_2608", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_2609", "content": "dementia [SEP] deficits and shows neuroprotective effects in vitro and in vivo dementia models.", "tokenized_content": [2, 7811, 3, 7961, 1930, 3661, 14345, 2564, 1922, 3596, 1930, 1922, 3597, 7811, 3130, 18, 3]}, "items": [{"id": "p_2609", "content": "Dementia [SEP] An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occup", "score": 1, "type": null, "tokenized_content": [2, 7811, 3, 1925, 5815, 6805, 5018, 4770, 1956, 3257, 1927, 13059, 10957, 1927, 5409, 5155, 1942, 11827, 1956, 3686, 2014, 6027, 3]}]}
{"query": {"id": "q_2610", "content": "maltolyl p-coumarate [SEP] ce cognitive function and neuroprotection, we newly synthesized maltolyl p-coumarate by the esterification of maltol and p-coumaric acid. In the pre", "tokenized_content": [2, 15505, 26558, 1024, 58, 17, 24503, 17488, 3, 5827, 4328, 2347, 1930, 21128, 16, 2038, 7471, 6653, 15505, 26558, 1024, 58, 17, 24503, 17488, 2007, 1920, 9603, 3123, 1927, 15505, 3]}, "items": [{"id": "p_2610", "content": "maltolyl p-coumarate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15505, 26558, 1024, 58, 17, 24503, 17488, 3, 3]}]}
{"query": {"id": "q_2611", "content": "maltol [SEP] ce cognitive function and neuroprotection, we newly synthesized maltolyl p-coumarate by the esterification of maltol and p-coumaric ac", "tokenized_content": [2, 15505, 1945, 3, 5827, 4328, 2347, 1930, 21128, 16, 2038, 7471, 6653, 15505, 26558, 1024, 58, 17, 24503, 17488, 2007, 1920, 9603, 3123, 1927, 15505, 1945, 1930, 58, 17, 24503, 3]}, "items": [{"id": "p_2611", "content": "maltol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15505, 1945, 3, 3]}]}
{"query": {"id": "q_2612", "content": "p-coumaric acid [SEP] esized maltolyl p-coumarate by the esterification of maltol and p-coumaric acid. In the present study, we investigated whether maltolyl p-couma", "tokenized_content": [2, 58, 17, 24503, 28867, 2687, 3, 11575, 6756, 15505, 26558, 1024, 58, 17, 24503, 17488, 2007, 1920, 9603, 3123, 1927, 15505, 1945, 1930, 58, 17, 24503, 28867, 2687, 18, 1922, 3]}, "items": [{"id": "p_2612", "content": "4-coumaric acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 24503, 28867, 2687, 3, 3]}]}
{"query": {"id": "q_2613", "content": "cognitive decline [SEP] udy, we investigated whether maltolyl p-coumarate could improve cognitive decline in scopolamine-injected rats and in amyloid beta peptide(1-42)-", "tokenized_content": [2, 4328, 6859, 3, 19803, 1012, 16, 2038, 3845, 3053, 15505, 26558, 1024, 58, 17, 24503, 17488, 2578, 3326, 4328, 6859, 1922, 25392, 10173, 25157, 17, 5624, 3615, 1930, 1922, 8186, 3]}, "items": [{"id": "p_2613", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_2614", "content": "scopolamine [SEP] whether maltolyl p-coumarate could improve cognitive decline in scopolamine-injected rats and in amyloid beta peptide(1-42)-infused rats. M", "tokenized_content": [2, 25392, 10173, 25157, 3, 3053, 15505, 26558, 1024, 58, 17, 24503, 17488, 2578, 3326, 4328, 6859, 1922, 25392, 10173, 25157, 17, 5624, 3615, 1930, 1922, 8186, 4666, 4207, 12, 21, 3]}, "items": [{"id": "p_2614", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_2615", "content": "amyloid beta peptide(1-42) [SEP] d improve cognitive decline in scopolamine-injected rats and in amyloid beta peptide(1-42)-infused rats. Maltolyl p-coumarate was found to attenuate cogni", "tokenized_content": [2, 8186, 4666, 4207, 12, 21, 17, 3858, 13, 3, 46, 3326, 4328, 6859, 1922, 25392, 10173, 25157, 17, 5624, 3615, 1930, 1922, 8186, 4666, 4207, 12, 21, 17, 3858, 13, 3]}, "items": [{"id": "p_2615", "content": "beta-amyloid peptide 1-42 (E22delta) click peptide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 8186, 4207, 21, 17, 3858, 12, 6602, 15091, 9551, 1019, 13, 15127, 4207, 3, 3]}]}
{"query": {"id": "q_2616", "content": "Maltolyl p-coumarate [SEP] e-injected rats and in amyloid beta peptide(1-42)-infused rats. Maltolyl p-coumarate was found to attenuate cognitive deficits in both rat models us", "tokenized_content": [2, 15505, 26558, 1024, 58, 17, 24503, 17488, 3, 47, 17, 5624, 3615, 1930, 1922, 8186, 4666, 4207, 12, 21, 17, 3858, 13, 17, 15610, 3615, 18, 15505, 26558, 1024, 58, 3]}, "items": [{"id": "p_2616", "content": "maltolyl p-coumarate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15505, 26558, 1024, 58, 17, 24503, 17488, 3, 3]}]}
{"query": {"id": "q_2617", "content": "cognitive deficits [SEP] 1-42)-infused rats. Maltolyl p-coumarate was found to attenuate cognitive deficits in both rat models using passive avoidance test and to reduce a", "tokenized_content": [2, 4328, 7961, 3, 21, 17, 3858, 13, 17, 15610, 3615, 18, 15505, 26558, 1024, 58, 17, 24503, 17488, 1982, 2435, 1942, 15500, 4328, 7961, 1922, 2321, 3067, 3130, 2193, 9832, 3]}, "items": [{"id": "p_2617", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_2618", "content": "glutamate [SEP] olyl p-coumarate, before exposed to amyloid beta peptide(1-42), glutamate or H2O2. We found that maltolyl p-coumarate significantly decre", "tokenized_content": [2, 7627, 3, 12865, 1024, 58, 17, 24503, 17488, 16, 3119, 4616, 1942, 8186, 4666, 4207, 12, 21, 17, 3858, 13, 16, 7627, 2014, 8307, 18, 2038, 2435, 1988, 15505, 26558, 3]}, "items": [{"id": "p_2618", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_2619", "content": "H2O2 [SEP] ate, before exposed to amyloid beta peptide(1-42), glutamate or H2O2. We found that maltolyl p-coumarate significantly decreased apo", "tokenized_content": [2, 8307, 3, 30280, 16, 3119, 4616, 1942, 8186, 4666, 4207, 12, 21, 17, 3858, 13, 16, 7627, 2014, 8307, 18, 2038, 2435, 1988, 15505, 26558, 1024, 58, 17, 24503, 17488, 3]}, "items": [{"id": "p_2619", "content": "Hydrogen Peroxide [SEP] A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unst", "score": 1, "type": null, "tokenized_content": [2, 6201, 12316, 3, 43, 3206, 23669, 5899, 2251, 1922, 8052, 3331, 1966, 43, 23739, 5899, 16, 6189, 2155, 16, 1930, 12259, 2246, 17, 20905, 18, 2176, 1977, 4322, 10769, 3]}]}
{"query": {"id": "q_2620", "content": "Alzheimer's disease [SEP] ltolyl p-coumarate is a potentially effective candidate against Alzheimer's disease that is characterized by wide spread neuronal death and progres", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 3457, 26558, 1024, 58, 17, 24503, 17488, 1977, 43, 5063, 3655, 6610, 3316, 9116, 11, 61, 2573, 1988, 1977, 4378, 2007, 4743, 6441, 5121, 3539, 3]}, "items": [{"id": "p_2620", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_2621", "content": "neuronal death [SEP] gainst Alzheimer's disease that is characterized by wide spread neuronal death and progressive decline of cognitive function.", "tokenized_content": [2, 5121, 3539, 3, 13241, 1031, 9116, 11, 61, 2573, 1988, 1977, 4378, 2007, 4743, 6441, 5121, 3539, 1930, 7529, 6859, 1927, 4328, 2347, 18, 3]}, "items": [{"id": "p_2621", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_2622", "content": "decline of cognitive function [SEP]  is characterized by wide spread neuronal death and progressive decline of cognitive function.", "tokenized_content": [2, 6859, 1927, 4328, 2347, 3, 1977, 4378, 2007, 4743, 6441, 5121, 3539, 1930, 7529, 6859, 1927, 4328, 2347, 18, 3]}, "items": [{"id": "p_2622", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_2623", "content": "warfarin [SEP] Interaction between warfarin and levofloxacin: case series.", "tokenized_content": [2, 16170, 3, 2835, 2192, 16170, 1930, 30129, 14217, 30, 3087, 4696, 18, 3]}, "items": [{"id": "p_2623", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_2624", "content": "levofloxacin [SEP] Interaction between warfarin and levofloxacin: case series.", "tokenized_content": [2, 30129, 14217, 3, 2835, 2192, 16170, 1930, 30129, 14217, 30, 3087, 4696, 18, 3]}, "items": [{"id": "p_2624", "content": "Levofloxacin [SEP] The L-isomer of Ofloxacin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30129, 14217, 3, 1920, 54, 17, 15348, 1927, 1927, 26226, 18, 3]}]}
{"query": {"id": "q_2625", "content": "Warfarin [SEP] Warfarin is the most widely used oral anticoagulant and is indicated for", "tokenized_content": [2, 16170, 3, 16170, 1977, 1920, 2501, 5673, 2251, 4726, 18509, 1930, 1977, 3391, 1958, 3]}, "items": [{"id": "p_2625", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_2626", "content": "Levofloxacin [SEP] al anticoagulant and is indicated for many clinical conditions. Levofloxacin, a fluoroquinolone, is one of the most commonly prescribed anti", "tokenized_content": [2, 30129, 14217, 3, 1969, 18509, 1930, 1977, 3391, 1958, 3086, 2535, 2961, 18, 30129, 14217, 16, 43, 23619, 13048, 16, 1977, 2340, 1927, 1920, 2501, 5384, 9975, 2246, 3]}, "items": [{"id": "p_2626", "content": "Levofloxacin [SEP] The L-isomer of Ofloxacin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30129, 14217, 3, 1920, 54, 17, 15348, 1927, 1927, 26226, 18, 3]}]}
{"query": {"id": "q_2627", "content": "fluoroquinolone [SEP]  and is indicated for many clinical conditions. Levofloxacin, a fluoroquinolone, is one of the most commonly prescribed antibiotics in clinical", "tokenized_content": [2, 23619, 13048, 3, 1930, 1977, 3391, 1958, 3086, 2535, 2961, 18, 30129, 14217, 16, 43, 23619, 13048, 16, 1977, 2340, 1927, 1920, 2501, 5384, 9975, 7560, 1922, 2535, 3]}, "items": [{"id": "p_2627", "content": "Fluoroquinolones [SEP] A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23619, 24909, 3, 43, 2210, 1927, 9012, 24909, 1956, 2019, 3464, 2340, 29700, 6761, 1930, 43, 16057, 25823, 2199, 2210, 18, 3]}]}
{"query": {"id": "q_2628", "content": "warfarin [SEP] have not revealed any significant drug-drug interaction between warfarin and levofloxacin, several case reports have indicated that levo", "tokenized_content": [2, 16170, 3, 2162, 2084, 3404, 2967, 2228, 2838, 17, 2838, 2835, 2192, 16170, 1930, 30129, 14217, 16, 2980, 3087, 4710, 2162, 3391, 1988, 30129, 3]}, "items": [{"id": "p_2628", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_2629", "content": "levofloxacin [SEP] aled any significant drug-drug interaction between warfarin and levofloxacin, several case reports have indicated that levofloxacin may sign", "tokenized_content": [2, 30129, 14217, 3, 19543, 1007, 2967, 2228, 2838, 17, 2838, 2835, 2192, 16170, 1930, 30129, 14217, 16, 2980, 3087, 4710, 2162, 3391, 1988, 30129, 14217, 2278, 2105, 3]}, "items": [{"id": "p_2629", "content": "Levofloxacin [SEP] The L-isomer of Ofloxacin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30129, 14217, 3, 1920, 54, 17, 15348, 1927, 1927, 26226, 18, 3]}]}
{"query": {"id": "q_2630", "content": "bleeding [SEP] nticoagulation effect of warfarin. We report 3 cases of serious bleeding complications that appear to be the result of the interaction b", "tokenized_content": [2, 7633, 3, 5891, 5670, 9981, 2495, 1927, 16170, 18, 2038, 3809, 23, 2919, 1927, 7433, 7633, 5021, 1988, 3267, 1942, 1998, 1920, 3211, 1927, 1920, 2835, 44, 3]}, "items": [{"id": "p_2630", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_2631", "content": "lamivudine [SEP] Mutations associated with lamivudine-resistance in therapy-na  ve hepatitis B virus (HBV) infected p", "tokenized_content": [2, 30208, 3, 3527, 2458, 1956, 30208, 17, 3554, 1922, 3181, 17, 4049, 3428, 7977, 44, 3413, 12, 8738, 13, 4014, 58, 3]}, "items": [{"id": "p_2631", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_2632", "content": "na [SEP] Mutations associated with lamivudine-resistance in therapy-na  ve hepatitis B virus (HBV) infected patients with and without ", "tokenized_content": [2, 4049, 3, 3527, 2458, 1956, 30208, 17, 3554, 1922, 3181, 17, 4049, 3428, 7977, 44, 3413, 12, 8738, 13, 4014, 2132, 1956, 1930, 2979, 3]}, "items": [{"id": "p_2632", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_2633", "content": "hepatitis B virus (HBV) infected [SEP] tations associated with lamivudine-resistance in therapy-na  ve hepatitis B virus (HBV) infected patients with and without HIV co-infection: implications for an", "tokenized_content": [2, 7977, 44, 3413, 12, 8738, 13, 4014, 3, 10687, 2443, 2458, 1956, 30208, 17, 3554, 1922, 3181, 17, 4049, 3428, 7977, 44, 3413, 12, 8738, 13, 4014, 2132, 1956, 1930, 3]}, "items": [{"id": "p_2633", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_2634", "content": "HIV co-infection [SEP]   ve hepatitis B virus (HBV) infected patients with and without HIV co-infection: implications for antiretroviral therapy in HBV and HIV co-infe", "tokenized_content": [2, 3525, 2081, 17, 2909, 3, 3428, 7977, 44, 3413, 12, 8738, 13, 4014, 2132, 1956, 1930, 2979, 3525, 2081, 17, 2909, 30, 7020, 1958, 14255, 3181, 1922, 8738, 1930, 3525, 3]}, "items": [{"id": "p_2634", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_2635", "content": "lamivudine [SEP] This was an exploratory study to investigate lamivudine-resistant hepatitis B virus (HBV) strains in selected lamivudin", "tokenized_content": [2, 30208, 3, 2052, 1982, 1925, 12733, 2161, 1942, 4482, 30208, 17, 4910, 7977, 44, 3413, 12, 8738, 13, 4046, 1922, 3790, 8282, 2068, 14287, 3]}, "items": [{"id": "p_2635", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_2636", "content": "hepatitis B [SEP] is was an exploratory study to investigate lamivudine-resistant hepatitis B virus (HBV) strains in selected lamivudine-na  ve HBV carriers ", "tokenized_content": [2, 7977, 44, 3, 1977, 1982, 1925, 12733, 2161, 1942, 4482, 30208, 17, 4910, 7977, 44, 3413, 12, 8738, 13, 4046, 1922, 3790, 30208, 17, 4049, 3428, 8738, 8974, 3]}, "items": [{"id": "p_2636", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_2637", "content": "na [SEP] esistant hepatitis B virus (HBV) strains in selected lamivudine-na  ve HBV carriers with and without human immunodeficiency virus ", "tokenized_content": [2, 4049, 3, 11575, 2156, 2031, 7977, 44, 3413, 12, 8738, 13, 4046, 1922, 3790, 30208, 17, 4049, 3428, 8738, 8974, 1956, 1930, 2979, 2616, 13141, 3413, 3]}, "items": [{"id": "p_2637", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_2638", "content": "human immunodeficiency virus (HIV) co-infection [SEP] ins in selected lamivudine-na  ve HBV carriers with and without human immunodeficiency virus (HIV) co-infection in South African patients. Thirty-five lamivudine-na  ve HBV in", "tokenized_content": [2, 2616, 13141, 3413, 12, 3525, 13, 2081, 17, 2909, 3, 2346, 1922, 3790, 30208, 17, 4049, 3428, 8738, 8974, 1956, 1930, 2979, 2616, 13141, 3413, 12, 3525, 13, 2081, 17, 3]}, "items": [{"id": "p_2638", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_2639", "content": "HBV infected [SEP] ection in South African patients. Thirty-five lamivudine-na  ve HBV infected patients with or without HIV co-infection were studied: 15 chro", "tokenized_content": [2, 8738, 4014, 3, 7495, 2001, 1922, 6061, 7050, 2132, 18, 9942, 17, 3628, 30208, 17, 4049, 3428, 8738, 4014, 2132, 1956, 2014, 2979, 3525, 2081, 17, 2909, 1985, 3942, 30, 3]}, "items": [{"id": "p_2639", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_2640", "content": "HIV co-infection [SEP] ty-five lamivudine-na  ve HBV infected patients with or without HIV co-infection were studied: 15 chronic HBV mono-infected patients and 20 HBV-", "tokenized_content": [2, 3525, 2081, 17, 2909, 3, 6227, 17, 3628, 30208, 17, 4049, 3428, 8738, 4014, 2132, 1956, 2014, 2979, 3525, 2081, 17, 2909, 1985, 3942, 30, 2461, 3724, 8738, 8914, 17, 3]}, "items": [{"id": "p_2640", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_2641", "content": "HBV mono-infected [SEP] ients with or without HIV co-infection were studied: 15 chronic HBV mono-infected patients and 20 HBV-HIV co-infected patients. The latter group ", "tokenized_content": [2, 8738, 8914, 17, 4014, 3, 10116, 4905, 1036, 1956, 2014, 2979, 3525, 2081, 17, 2909, 1985, 3942, 30, 2461, 3724, 8738, 8914, 17, 4014, 2132, 1930, 2036, 8738, 17, 3525, 3]}, "items": [{"id": "p_2641", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_2642", "content": "HBsAg [SEP] s. The latter group was further sub-divided into 13 occult HBV (HBsAg-negative) and 7 overt HBV (HBsAg- positive) patients. HBsAg, an", "tokenized_content": [2, 17596, 3, 61, 18, 1920, 6296, 2210, 1982, 2520, 2316, 17, 5831, 2460, 2590, 23065, 8738, 12, 17596, 17, 3136, 13, 1930, 27, 14702, 8738, 12, 17596, 17, 2843, 13, 3]}, "items": [{"id": "p_2642", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_2643", "content": "tyrosine [SEP] criptase (RT) primers, followed by direct sequencing across the tyrosine-methionine-aspartate-aspartate (YMDD) motif of the major cataly", "tokenized_content": [2, 6941, 3, 3828, 25958, 4127, 12, 4341, 13, 5696, 16, 3489, 2007, 3083, 4754, 3436, 1920, 6941, 17, 12417, 17, 12878, 17, 12878, 12, 23143, 10882, 13, 5219, 1927, 1920, 3]}, "items": [{"id": "p_2643", "content": "Tyrosine [SEP] A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HO", "score": 1, "type": null, "tokenized_content": [2, 6941, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 1922, 3555, 2176, 1977, 6653, 2037, 17388, 18, 2176, 1977, 2222, 1920, 7897, 1927, 19280, 31, 6918, 6673, 3]}]}
{"query": {"id": "q_2644", "content": "methionine [SEP] (RT) primers, followed by direct sequencing across the tyrosine-methionine-aspartate-aspartate (YMDD) motif of the major catalytic region ", "tokenized_content": [2, 12417, 3, 12, 4341, 13, 5696, 16, 3489, 2007, 3083, 4754, 3436, 1920, 6941, 17, 12417, 17, 12878, 17, 12878, 12, 23143, 10882, 13, 5219, 1927, 1920, 3044, 6804, 3031, 3]}, "items": [{"id": "p_2644", "content": "Methionine [SEP] A sulfur-containing essential L-amino acid that is important in many body functions.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12417, 3, 43, 12585, 17, 3165, 4415, 54, 17, 3835, 2687, 1988, 1977, 2715, 1922, 3086, 3362, 4088, 18, 3]}]}
{"query": {"id": "q_2645", "content": "aspartate [SEP] s, followed by direct sequencing across the tyrosine-methionine-aspartate-aspartate (YMDD) motif of the major catalytic region in the C d", "tokenized_content": [2, 12878, 3, 61, 16, 3489, 2007, 3083, 4754, 3436, 1920, 6941, 17, 12417, 17, 12878, 17, 12878, 12, 23143, 10882, 13, 5219, 1927, 1920, 3044, 6804, 3031, 1922, 1920, 45, 3]}, "items": [{"id": "p_2645", "content": "Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca", "score": 1, "type": null, "tokenized_content": [2, 23047, 2687, 3, 2340, 1927, 1920, 2447, 17, 4415, 3835, 4576, 5384, 6966, 1922, 1920, 54, 17, 2386, 18, 2176, 1977, 2435, 1922, 3555, 1930, 4793, 16, 4369, 1922, 9523, 2332, 3]}]}
{"query": {"id": "q_2646", "content": "NMDA [SEP] Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsai", "tokenized_content": [2, 10976, 3, 3486, 2886, 1922, 10976, 8151, 7489, 1927, 11553, 12946, 2085, 6014, 2286, 2126, 1922, 43, 19137, 1033, 3]}, "items": [{"id": "p_2646", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_2647", "content": "morphine [SEP] Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: compa", "tokenized_content": [2, 11553, 3, 3486, 2886, 1922, 10976, 8151, 7489, 1927, 11553, 12946, 2085, 6014, 2286, 2126, 1922, 43, 19156, 2322, 1927, 7733, 3594, 30, 2059, 1019, 3]}, "items": [{"id": "p_2647", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_2648", "content": "capsaicin [SEP] n NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pa", "tokenized_content": [2, 19156, 3, 56, 10976, 8151, 7489, 1927, 11553, 12946, 2085, 6014, 2286, 2126, 1922, 43, 19156, 2322, 1927, 7733, 3594, 30, 5768, 1942, 2288, 3130, 1927, 3939, 3838, 3]}, "items": [{"id": "p_2648", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_2649", "content": "pain [SEP] of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain.", "tokenized_content": [2, 3594, 3, 1927, 11553, 12946, 2085, 6014, 2286, 2126, 1922, 43, 19156, 2322, 1927, 7733, 3594, 30, 5768, 1942, 2288, 3130, 1927, 3939, 3594, 18, 3]}, "items": [{"id": "p_2649", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2650", "content": "acute pain [SEP] apsaicin model of persistent pain: comparisons to two models of acute pain.", "tokenized_content": [2, 3939, 3594, 3, 16311, 5504, 3665, 2322, 1927, 7733, 3594, 30, 5768, 1942, 2288, 3130, 1927, 3939, 3594, 18, 3]}, "items": [{"id": "p_2650", "content": "Acute Pain [SEP] Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, char", "score": 1, "type": null, "tokenized_content": [2, 3939, 3594, 3, 10702, 1954, 15335, 1941, 16, 8740, 2903, 16, 2014, 6024, 3903, 15826, 2458, 1956, 7176, 2014, 2573, 16, 1956, 2486, 17, 3608, 5185, 16, 2618, 3]}]}
{"query": {"id": "q_2651", "content": "acute pain [SEP] In acute pain models, N-methyl-D-aspartate (NMDA) antagonists enhance the ant", "tokenized_content": [2, 3939, 3594, 3, 1922, 3939, 3594, 3130, 16, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 10515, 4826, 1920, 4942, 3]}, "items": [{"id": "p_2651", "content": "Acute Pain [SEP] Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, char", "score": 1, "type": null, "tokenized_content": [2, 3939, 3594, 3, 10702, 1954, 15335, 1941, 16, 8740, 2903, 16, 2014, 6024, 3903, 15826, 2458, 1956, 7176, 2014, 2573, 16, 1956, 2486, 17, 3608, 5185, 16, 2618, 3]}]}
{"query": {"id": "q_2652", "content": "N-methyl-D-aspartate [SEP] In acute pain models, N-methyl-D-aspartate (NMDA) antagonists enhance the antinociceptive effects of morph", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 1922, 3939, 3594, 3130, 16, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 10515, 4826, 1920, 29927, 2564, 1927, 3901, 3]}, "items": [{"id": "p_2652", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_2653", "content": "NMDA [SEP] In acute pain models, N-methyl-D-aspartate (NMDA) antagonists enhance the antinociceptive effects of morphine to", "tokenized_content": [2, 10976, 3, 1922, 3939, 3594, 3130, 16, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 10515, 4826, 1920, 29927, 2564, 1927, 11553, 1942, 3]}, "items": [{"id": "p_2653", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_2654", "content": "morphine [SEP] rtate (NMDA) antagonists enhance the antinociceptive effects of morphine to a greater extent in males than females. The purpose of this ", "tokenized_content": [2, 11553, 3, 25551, 2057, 12, 10976, 13, 10515, 4826, 1920, 29927, 2564, 1927, 11553, 1942, 43, 3430, 5064, 1922, 5129, 2254, 5027, 18, 1920, 5120, 1927, 2052, 3]}, "items": [{"id": "p_2654", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_2655", "content": "pain [SEP] In acute pain models, N-methyl-D-aspartate (NMDA) antagonists enhance the ant", "tokenized_content": [2, 3594, 3, 1922, 3939, 3594, 3130, 16, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 10515, 4826, 1920, 4942, 3]}, "items": [{"id": "p_2655", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2656", "content": "hyperalgesia [SEP] d duration of the nociceptive stimulus. To this end, persistent hyperalgesia was induced by administration of capsaicin in the tail of gonad", "tokenized_content": [2, 21525, 3, 46, 4392, 1927, 1920, 19034, 5794, 18, 1942, 2052, 2482, 16, 7733, 21525, 1982, 2719, 2007, 4183, 1927, 19156, 1922, 1920, 5281, 1927, 11690, 3]}, "items": [{"id": "p_2656", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_2657", "content": "capsaicin [SEP] s end, persistent hyperalgesia was induced by administration of capsaicin in the tail of gonadally intact F344 rats, following which the ", "tokenized_content": [2, 19156, 3, 61, 2482, 16, 7733, 21525, 1982, 2719, 2007, 4183, 1927, 19156, 1922, 1920, 5281, 1927, 21282, 1954, 6718, 14499, 6609, 3615, 16, 2894, 2154, 1920, 3]}, "items": [{"id": "p_2657", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_2658", "content": "dextromethorphan [SEP] rawal procedures. In males, the non-competitive NMDA antagonist dextromethorphan enhanced the antihyperalgesic effect of low to moderate doses o", "tokenized_content": [2, 20256, 4191, 1963, 4255, 1928, 3, 7429, 1923, 4869, 18, 1922, 5129, 16, 1920, 2447, 17, 10362, 10976, 8151, 20256, 4191, 1963, 4255, 1928, 4256, 1920, 12946, 2085, 6014, 2286, 3]}, "items": [{"id": "p_2658", "content": "Dextromethorphan [SEP] Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough cen", "score": 1, "type": null, "tokenized_content": [2, 20256, 4191, 1963, 4255, 1928, 3, 4963, 5729, 1927, 20256, 8478, 18547, 1988, 3661, 2149, 5173, 2743, 1942, 2980, 3451, 1927, 1920, 3068, 16, 2710, 1920, 19482, 13588, 14585, 3]}]}
{"query": {"id": "q_2659", "content": "proteinuria [SEP] Development of proteinuria after switch to sirolimus-based immunosuppression in long-term ", "tokenized_content": [2, 15831, 3, 2740, 1927, 15831, 2256, 6195, 1942, 4520, 24124, 17, 2454, 15858, 1922, 2815, 17, 2576, 3]}, "items": [{"id": "p_2659", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2660", "content": "sirolimus [SEP] Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patient", "tokenized_content": [2, 4520, 24124, 3, 2740, 1927, 15831, 2256, 6195, 1942, 4520, 24124, 17, 2454, 15858, 1922, 2815, 17, 2576, 4435, 5192, 2774, 3]}, "items": [{"id": "p_2660", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_2661", "content": "renal dysfunction [SEP] Calcineurin-inhibitor therapy can lead to renal dysfunction in heart transplantation patients. The novel immunosuppressive ", "tokenized_content": [2, 4604, 5273, 3, 19555, 17, 4106, 3181, 2112, 2949, 1942, 4604, 5273, 1922, 4003, 6530, 2132, 18, 1920, 4008, 12910, 3]}, "items": [{"id": "p_2661", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2662", "content": "sirolmus [SEP] transplantation patients. The novel immunosuppressive (IS) drug sirolmus (Srl) lacks nephrotoxic effects; however, proteinuria associate", "tokenized_content": [2, 4520, 1945, 23084, 3, 6530, 2132, 18, 1920, 4008, 12910, 12, 1977, 13, 2838, 4520, 1945, 23084, 12, 4581, 1024, 13, 13012, 22994, 10605, 2564, 31, 2406, 16, 15831, 11774, 3]}, "items": [{"id": "p_2662", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_2663", "content": "Srl [SEP] ation patients. The novel immunosuppressive (IS) drug sirolmus (Srl) lacks nephrotoxic effects; however, proteinuria associated wit", "tokenized_content": [2, 4581, 1024, 3, 2019, 2001, 2132, 18, 1920, 4008, 12910, 12, 1977, 13, 2838, 4520, 1945, 23084, 12, 4581, 1024, 13, 13012, 22994, 10605, 2564, 31, 2406, 16, 15831, 2458, 3]}, "items": [{"id": "p_2663", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_2664", "content": "nephrotoxic [SEP] nts. The novel immunosuppressive (IS) drug sirolmus (Srl) lacks nephrotoxic effects; however, proteinuria associated with Srl has been repo", "tokenized_content": [2, 22994, 10605, 3, 17969, 18, 1920, 4008, 12910, 12, 1977, 13, 2838, 4520, 1945, 23084, 12, 4581, 1024, 13, 13012, 22994, 10605, 2564, 31, 2406, 16, 15831, 2458, 1956, 4581, 3]}, "items": [{"id": "p_2664", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2665", "content": "proteinuria [SEP] ve (IS) drug sirolmus (Srl) lacks nephrotoxic effects; however, proteinuria associated with Srl has been reported following renal transplan", "tokenized_content": [2, 15831, 3, 3428, 12, 1977, 13, 2838, 4520, 1945, 23084, 12, 4581, 1024, 13, 13012, 22994, 10605, 2564, 31, 2406, 16, 15831, 2458, 1956, 4581, 1024, 2258, 2252, 2568, 2894, 3]}, "items": [{"id": "p_2665", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2666", "content": "cyclosporine [SEP] study, long-term cardiac transplant patients were switched from cyclosporine to Srl-based IS. Concomitant IS consisted of mycophenolate mofe", "tokenized_content": [2, 21002, 3, 2161, 16, 2815, 17, 2576, 4435, 5192, 2132, 1985, 15523, 2037, 21002, 1942, 4581, 1024, 17, 2454, 1977, 18, 8537, 1977, 6994, 1927, 5078, 23965, 2010, 25976, 1021, 3]}, "items": [{"id": "p_2666", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_2667", "content": "mycophenolate mofetil [SEP]  from cyclosporine to Srl-based IS. Concomitant IS consisted of mycophenolate mofetil +/- steroids. Proteinuria increased significantly from a median", "tokenized_content": [2, 5078, 23965, 2010, 25976, 4988, 1024, 3, 2037, 21002, 1942, 4581, 1024, 17, 2454, 1977, 18, 8537, 1977, 6994, 1927, 5078, 23965, 2010, 25976, 4988, 1024, 15, 19, 17, 13039, 3]}, "items": [{"id": "p_2667", "content": "mycophenolate mofetil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5078, 23965, 2010, 25976, 4988, 1024, 3, 3]}]}
{"query": {"id": "q_2668", "content": "steroids [SEP] based IS. Concomitant IS consisted of mycophenolate mofetil +/- steroids. Proteinuria increased significantly from a median of 0.13 g/da", "tokenized_content": [2, 13039, 3, 2454, 1977, 18, 8537, 1977, 6994, 1927, 5078, 23965, 2010, 25976, 4988, 1024, 15, 19, 17, 13039, 18, 15831, 2502, 2567, 2037, 43, 4181, 1927, 20, 18, 2590, 3]}, "items": [{"id": "p_2668", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_2669", "content": "ACE inhibitor [SEP] a (>1.0 g/day); this increased to 22.9% postswitch (p = 0.006). ACE inhibitor and angiotensin-releasing blocker (ARB) therapy reduced protein", "tokenized_content": [2, 8298, 4106, 3, 43, 12, 34, 21, 18, 20, 49, 19, 3007, 13, 31, 2052, 2502, 1942, 2950, 18, 29, 9, 9999, 24107, 12, 58, 33, 20, 18, 12791, 13, 3]}, "items": [{"id": "p_2669", "content": "Angiotensin-Converting Enzyme Inhibitors [SEP] A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect", "score": 1, "type": null, "tokenized_content": [2, 10814, 17, 15025, 4113, 4472, 3, 43, 2921, 1927, 4195, 6098, 2730, 11615, 2032, 1920, 2311, 1927, 5579, 1930, 4003, 4574, 18, 2611, 10788, 2310, 12173, 2495, 3]}]}
{"query": {"id": "q_2670", "content": "angiotensin-releasing blocker [SEP] is increased to 22.9% postswitch (p = 0.006). ACE inhibitor and angiotensin-releasing blocker (ARB) therapy reduced proteinuria development. Patients without", "tokenized_content": [2, 10814, 17, 13182, 14580, 3, 1977, 2502, 1942, 2950, 18, 29, 9, 9999, 24107, 12, 58, 33, 20, 18, 12791, 13, 18, 8298, 4106, 1930, 10814, 17, 13182, 14580, 12, 3]}, "items": [{"id": "p_2670", "content": "Angiotensin Receptor Antagonists [SEP] Agents that antagonize ANGIOTENSIN RECEPTORS. Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10814, 3148, 10515, 3, 4820, 1988, 28104, 10814, 4086, 18, 3086, 4195, 1922, 2052, 2921, 4475, 2758, 1920, 10814, 2601, 21, 3148, 18, 3]}]}
{"query": {"id": "q_2671", "content": "ARB [SEP] h (p = 0.006). ACE inhibitor and angiotensin-releasing blocker (ARB) therapy reduced proteinuria development. Patients without prot", "tokenized_content": [2, 9859, 3, 50, 12, 58, 33, 20, 18, 12791, 13, 18, 8298, 4106, 1930, 10814, 17, 13182, 14580, 12, 9859, 13, 3181, 3028, 15831, 2740, 18, 2132, 2979, 2844, 3]}, "items": [{"id": "p_2671", "content": "Angiotensin Receptor Antagonists [SEP] Agents that antagonize ANGIOTENSIN RECEPTORS. Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10814, 3148, 10515, 3, 4820, 1988, 28104, 10814, 4086, 18, 3086, 4195, 1922, 2052, 2921, 4475, 2758, 1920, 10814, 2601, 21, 3148, 18, 3]}]}
{"query": {"id": "q_2672", "content": "ACEi [SEP] ct on renal function in these patients. Srl should be used with ACEi/ARB therapy and patients monitored for proteinuria and increase", "tokenized_content": [2, 8298, 1033, 3, 3369, 1990, 4604, 2347, 1922, 2144, 2132, 18, 4581, 1024, 3066, 1998, 2251, 1956, 8298, 1033, 19, 9859, 3181, 1930, 2132, 7027, 1958, 15831, 1930, 2760, 3]}, "items": [{"id": "p_2672", "content": "Angiotensin-Converting Enzyme Inhibitors [SEP] A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect", "score": 1, "type": null, "tokenized_content": [2, 10814, 17, 15025, 4113, 4472, 3, 43, 2921, 1927, 4195, 6098, 2730, 11615, 2032, 1920, 2311, 1927, 5579, 1930, 4003, 4574, 18, 2611, 10788, 2310, 12173, 2495, 3]}]}
{"query": {"id": "q_2673", "content": "N-pyrimidinyl-2-phenoxyacetamides [SEP] Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.", "tokenized_content": [2, 56, 17, 17015, 7650, 2199, 17, 22, 17, 3037, 7221, 27457, 1036, 3, 4271, 1927, 56, 17, 17015, 7650, 2199, 17, 22, 17, 3037, 7221, 27457, 1036, 1966, 10125, 27045, 3]}, "items": [{"id": "p_2673", "content": "Phenoxyacetates [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3037, 7221, 18007, 1036, 3, 3]}]}
{"query": {"id": "q_2674", "content": "adenosine [SEP] Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.", "tokenized_content": [2, 10125, 3, 4271, 1927, 56, 17, 17015, 7650, 2199, 17, 22, 17, 3037, 7221, 27457, 1036, 1966, 10125, 27045, 3148, 10515, 18, 3]}, "items": [{"id": "p_2674", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_2675", "content": "N-pyrimidinyl-2-phenoxyacetamide [SEP] A series of N-pyrimidinyl-2-phenoxyacetamide adenosine A(2A) antagonists is described. SAR studies led to co", "tokenized_content": [2, 56, 17, 17015, 7650, 2199, 17, 22, 17, 3037, 7221, 27457, 3, 43, 4696, 1927, 56, 17, 17015, 7650, 2199, 17, 22, 17, 3037, 7221, 27457, 10125, 43, 12, 5251, 3]}, "items": [{"id": "p_2675", "content": "Phenoxyacetates [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3037, 7221, 18007, 1036, 3, 3]}]}
{"query": {"id": "q_2676", "content": "adenosine [SEP] A series of N-pyrimidinyl-2-phenoxyacetamide adenosine A(2A) antagonists is described. SAR studies led to compound 14 ", "tokenized_content": [2, 10125, 3, 43, 4696, 1927, 56, 17, 17015, 7650, 2199, 17, 22, 17, 3037, 7221, 27457, 10125, 43, 12, 5251, 13, 10515, 1977, 2910, 18, 9851, 2351, 4866, 1942, 3547, 3]}, "items": [{"id": "p_2676", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_2677", "content": "haloperidol [SEP] (A(1)/A(2A) > 100), and efficacy (MED 10 mg/kg p.o.) in the rat haloperidol-induced catalepsy model for Parkinson's disease.", "tokenized_content": [2, 25107, 3, 12, 43, 12, 21, 13, 19, 43, 12, 5251, 13, 34, 2813, 13, 16, 1930, 4348, 12, 2242, 2119, 2786, 19, 3621, 58, 18, 57, 18, 13, 1922, 3]}, "items": [{"id": "p_2677", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_2678", "content": "catalepsy [SEP] and efficacy (MED 10 mg/kg p.o.) in the rat haloperidol-induced catalepsy model for Parkinson's disease.", "tokenized_content": [2, 4233, 9431, 1012, 3, 1930, 4348, 12, 2242, 2119, 2786, 19, 3621, 58, 18, 57, 18, 13, 1922, 1920, 3067, 25107, 17, 2719, 4233, 9431, 1012, 2322, 1958, 10124, 11, 3]}, "items": [{"id": "p_2678", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_2679", "content": "Parkinson's disease [SEP]  mg/kg p.o.) in the rat haloperidol-induced catalepsy model for Parkinson's disease.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 2786, 19, 3621, 58, 18, 57, 18, 13, 1922, 1920, 3067, 25107, 17, 2719, 4233, 9431, 1012, 2322, 1958, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_2679", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2680", "content": "Methamphetamine [SEP] Methamphetamine-induced neurotoxicity and microglial activation are not mediate", "tokenized_content": [2, 20375, 3, 20375, 17, 2719, 18034, 1930, 13810, 2936, 2032, 2084, 8265, 3]}, "items": [{"id": "p_2680", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_2681", "content": "neurotoxicity [SEP] Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine recep", "tokenized_content": [2, 18034, 3, 20375, 17, 2719, 18034, 1930, 13810, 2936, 2032, 2084, 3434, 2007, 27634, 24590, 2793, 3]}, "items": [{"id": "p_2681", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2682", "content": "Methamphetamine [SEP] Methamphetamine (METH) damages dopamine (DA) nerve endings by a process that ha", "tokenized_content": [2, 20375, 3, 20375, 12, 2295, 13, 22083, 7964, 12, 3692, 13, 5507, 17970, 1036, 2007, 43, 2585, 1988, 2118, 3]}, "items": [{"id": "p_2682", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_2683", "content": "METH [SEP] Methamphetamine (METH) damages dopamine (DA) nerve endings by a process that has been", "tokenized_content": [2, 2295, 3, 20375, 12, 2295, 13, 22083, 7964, 12, 3692, 13, 5507, 17970, 1036, 2007, 43, 2585, 1988, 2258, 2252, 3]}, "items": [{"id": "p_2683", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_2684", "content": "dopamine [SEP] Methamphetamine (METH) damages dopamine (DA) nerve endings by a process that has been linked to microgl", "tokenized_content": [2, 7964, 3, 20375, 12, 2295, 13, 22083, 7964, 12, 3692, 13, 5507, 17970, 1036, 2007, 43, 2585, 1988, 2258, 2252, 4624, 1942, 7586, 3]}, "items": [{"id": "p_2684", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2685", "content": "DA [SEP] Methamphetamine (METH) damages dopamine (DA) nerve endings by a process that has been linked to microglial ", "tokenized_content": [2, 3692, 3, 20375, 12, 2295, 13, 22083, 7964, 12, 3692, 13, 5507, 17970, 1036, 2007, 43, 2585, 1988, 2258, 2252, 4624, 1942, 13810, 3]}, "items": [{"id": "p_2685", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2686", "content": "MPTP [SEP] cific fractalkine receptor (CX3CR1) as an important mediator of MPTP-induced neurodegeneration of DA neurons. Because the CNS damage", "tokenized_content": [2, 19043, 3, 3371, 19894, 1030, 27634, 24590, 3148, 12, 26652, 13, 1966, 1925, 2715, 11370, 1927, 19043, 17, 2719, 14481, 1927, 3692, 3558, 18, 2882, 1920, 7520, 4293, 3]}, "items": [{"id": "p_2686", "content": "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [SEP] A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 4963, 17, 24, 17, 7971, 17, 21, 16, 22, 16, 23, 16, 26, 17, 21196, 18425, 5802, 3, 43, 12214, 20919, 3547, 2154, 9300, 14104, 2535, 16, 4399, 16, 1930, 6598, 5996, 1988, 10223, 2690, 3]}]}
{"query": {"id": "q_2687", "content": "neurodegeneration [SEP] kine receptor (CX3CR1) as an important mediator of MPTP-induced neurodegeneration of DA neurons. Because the CNS damage caused by METH and MPTP i", "tokenized_content": [2, 14481, 3, 5838, 3148, 12, 26652, 13, 1966, 1925, 2715, 11370, 1927, 19043, 17, 2719, 14481, 1927, 3692, 3558, 18, 2882, 1920, 7520, 4293, 4189, 2007, 2295, 1930, 19043, 51, 3]}, "items": [{"id": "p_2687", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2688", "content": "CNS damage [SEP] or of MPTP-induced neurodegeneration of DA neurons. Because the CNS damage caused by METH and MPTP is highly selective for the DA neuronal", "tokenized_content": [2, 7520, 4293, 3, 2014, 1927, 19043, 17, 2719, 14481, 1927, 3692, 3558, 18, 2882, 1920, 7520, 4293, 4189, 2007, 2295, 1930, 19043, 1977, 3626, 5328, 1958, 1920, 3692, 5121, 3]}, "items": [{"id": "p_2688", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2689", "content": "neurotoxicity [SEP]  highly selective for the DA neuronal system in mouse models of neurotoxicity, we hypothesized that the CX3CR1 plays a role in METH-induced n", "tokenized_content": [2, 18034, 3, 3626, 5328, 1958, 1920, 3692, 5121, 2433, 1922, 3321, 3130, 1927, 18034, 16, 2038, 7149, 1988, 1920, 26652, 5705, 43, 2770, 1922, 2295, 17, 2719, 56, 3]}, "items": [{"id": "p_2689", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2690", "content": "tacrolimus [SEP] Recovery of tacrolimus-associated brachial neuritis after conversion to everolimus in ", "tokenized_content": [2, 21801, 3, 5241, 1927, 21801, 17, 2458, 19459, 2974, 3678, 2256, 7309, 1942, 24687, 1922, 3]}, "items": [{"id": "p_2690", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_2691", "content": "brachial neuritis [SEP] Recovery of tacrolimus-associated brachial neuritis after conversion to everolimus in a pediatric renal transplant ", "tokenized_content": [2, 19459, 2974, 3678, 3, 5241, 1927, 21801, 17, 2458, 19459, 2974, 3678, 2256, 7309, 1942, 24687, 1922, 43, 7460, 4604, 5192, 3]}, "items": [{"id": "p_2691", "content": "Brachial Plexus Neuritis [SEP] A syndrome associated with inflammation of the BRACHIAL PLEXUS. Clinical features include severe pain in the shoulder region whi", "score": 1, "type": null, "tokenized_content": [2, 19459, 17438, 2974, 3678, 3, 43, 4741, 2458, 1956, 4531, 1927, 1920, 19459, 17438, 18, 2535, 4075, 3951, 4010, 3594, 1922, 1920, 12104, 3031, 2003, 1033, 3]}]}
{"query": {"id": "q_2692", "content": "everolimus [SEP]  of tacrolimus-associated brachial neuritis after conversion to everolimus in a pediatric renal transplant recipient--case report and revi", "tokenized_content": [2, 24687, 3, 1927, 21801, 17, 2458, 19459, 2974, 3678, 2256, 7309, 1942, 24687, 1922, 43, 7460, 4604, 5192, 10664, 17, 17, 3087, 3809, 1930, 5197, 1033, 3]}, "items": [{"id": "p_2692", "content": "everolimus [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24687, 3, 3]}]}
{"query": {"id": "q_2693", "content": "TAC [SEP] TAC has been shown to be a potent immunosuppressive agent for solid", "tokenized_content": [2, 9214, 3, 9214, 2258, 2252, 2522, 1942, 1998, 43, 6828, 12910, 5899, 1958, 5358, 3]}, "items": [{"id": "p_2693", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_2694", "content": "Neurotoxicity [SEP] uppressive agent for solid organ transplantation in pediatrics. Neurotoxicity is a potentially serious toxic effect. It is characterized by e", "tokenized_content": [2, 18034, 3, 2353, 5932, 5899, 1958, 5358, 3090, 6530, 1922, 22786, 18, 18034, 1977, 43, 5063, 7433, 6161, 2495, 18, 2176, 1977, 4378, 2007, 47, 3]}, "items": [{"id": "p_2694", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2695", "content": "encephalopathy [SEP] y is a potentially serious toxic effect. It is characterized by encephalopathy, headaches, seizures, or neurological deficits. Here, we descri", "tokenized_content": [2, 19393, 3, 67, 1977, 43, 5063, 7433, 6161, 2495, 18, 2176, 1977, 4378, 2007, 19393, 16, 24339, 16, 10060, 16, 2014, 7605, 7961, 18, 3410, 16, 2038, 12487, 3027, 3]}, "items": [{"id": "p_2695", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_2696", "content": "headaches [SEP] ly serious toxic effect. It is characterized by encephalopathy, headaches, seizures, or neurological deficits. Here, we describe an eight", "tokenized_content": [2, 24339, 3, 7518, 7433, 6161, 2495, 18, 2176, 1977, 4378, 2007, 19393, 16, 24339, 16, 10060, 16, 2014, 7605, 7961, 18, 3410, 16, 2038, 5993, 1925, 5066, 3]}, "items": [{"id": "p_2696", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_2697", "content": "seizures [SEP] toxic effect. It is characterized by encephalopathy, headaches, seizures, or neurological deficits. Here, we describe an eight-and-a-hal", "tokenized_content": [2, 10060, 3, 6161, 2495, 18, 2176, 1977, 4378, 2007, 19393, 16, 24339, 16, 10060, 16, 2014, 7605, 7961, 18, 3410, 16, 2038, 5993, 1925, 5066, 17, 1930, 17, 43, 17, 3]}, "items": [{"id": "p_2697", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2698", "content": "neurological deficits [SEP]  It is characterized by encephalopathy, headaches, seizures, or neurological deficits. Here, we describe an eight-and-a-half-yr-old male renal transp", "tokenized_content": [2, 7605, 7961, 3, 2176, 1977, 4378, 2007, 19393, 16, 24339, 16, 10060, 16, 2014, 7605, 7961, 18, 3410, 16, 2038, 5993, 1925, 5066, 17, 1930, 17, 43, 17, 4768, 17, 3]}, "items": [{"id": "p_2698", "content": "Neurologic Manifestations [SEP] Clinical signs and symptoms caused by nervous system injury or dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14314, 10952, 3, 2535, 6879, 1930, 3601, 4189, 2007, 7580, 2433, 4047, 2014, 5273, 18, 3]}]}
{"query": {"id": "q_2699", "content": "myelitis [SEP] ervical cord and right brachial plexus roots indicative of both myelitis and right brachial plexitis. Symptoms persisted for three month", "tokenized_content": [2, 5707, 3678, 3, 2668, 9833, 1923, 6670, 1930, 3659, 19459, 17438, 9398, 10779, 1927, 2321, 5707, 3678, 1930, 3659, 19459, 11856, 3678, 18, 3601, 14583, 1958, 2559, 2935, 3]}, "items": [{"id": "p_2699", "content": "Myelitis [SEP] Inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia", "score": 1, "type": null, "tokenized_content": [2, 5707, 3678, 3, 4531, 1927, 1920, 6071, 6670, 18, 4322, 3059, 22608, 3951, 5024, 31, 8904, 3902, 31, 6071, 6670, 31, 1930, 7716, 3]}]}
{"query": {"id": "q_2700", "content": "brachial plexitis [SEP] ght brachial plexus roots indicative of both myelitis and right brachial plexitis. Symptoms persisted for three months despite TAC dose reduction", "tokenized_content": [2, 19459, 11856, 3678, 3, 6101, 1031, 19459, 17438, 9398, 10779, 1927, 2321, 5707, 3678, 1930, 3659, 19459, 11856, 3678, 18, 3601, 14583, 1958, 2559, 3221, 4281, 9214, 3253, 3378, 3]}, "items": [{"id": "p_2700", "content": "Brachial Plexus Neuritis [SEP] A syndrome associated with inflammation of the BRACHIAL PLEXUS. Clinical features include severe pain in the shoulder region whi", "score": 1, "type": null, "tokenized_content": [2, 19459, 17438, 2974, 3678, 3, 43, 4741, 2458, 1956, 4531, 1927, 1920, 19459, 17438, 18, 2535, 4075, 3951, 4010, 3594, 1922, 1920, 12104, 3031, 2003, 1033, 3]}]}
{"query": {"id": "q_2701", "content": "methylprednisolone [SEP] te TAC dose reduction, administration of IVIG and four doses of methylprednisolone pulse therapy. Improvement and eventually full recovery only oc", "tokenized_content": [2, 30087, 3, 3602, 9214, 3253, 3378, 16, 4183, 1927, 22413, 1930, 3006, 5312, 1927, 30087, 7110, 3181, 18, 4990, 1930, 10042, 4125, 5241, 2444, 5084, 3]}, "items": [{"id": "p_2701", "content": "Methylprednisolone [SEP] A PREDNISOLONE derivative with similar anti-inflammatory action.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30087, 3, 43, 22025, 10533, 1956, 2551, 2246, 17, 3769, 4615, 18, 3]}]}
{"query": {"id": "q_2702", "content": "everolimus [SEP] er TAC was completely discontinued and successfully replaced by everolimus.", "tokenized_content": [2, 24687, 3, 2668, 9214, 1982, 5796, 16087, 1930, 6664, 8403, 2007, 24687, 18, 3]}, "items": [{"id": "p_2702", "content": "everolimus [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24687, 3, 3]}]}
{"query": {"id": "q_2703", "content": "Valvular heart disease [SEP] Valvular heart disease in patients with Parkinson's disease treated with pergolide. Co", "tokenized_content": [2, 25025, 4003, 2573, 3, 25025, 4003, 2573, 1922, 2132, 1956, 10124, 11, 61, 2573, 2868, 1956, 2079, 3827, 12191, 3695, 18, 2081, 3]}, "items": [{"id": "p_2703", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_2704", "content": "Parkinson's disease [SEP] Valvular heart disease in patients with Parkinson's disease treated with pergolide. Course following treatment modification", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 25025, 4003, 2573, 1922, 2132, 1956, 10124, 11, 61, 2573, 2868, 1956, 2079, 3827, 12191, 3695, 18, 4914, 2894, 2311, 6295, 3]}, "items": [{"id": "p_2704", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2705", "content": "pergolide [SEP] heart disease in patients with Parkinson's disease treated with pergolide. Course following treatment modifications.", "tokenized_content": [2, 2079, 3827, 12191, 3695, 3, 4003, 2573, 1922, 2132, 1956, 10124, 11, 61, 2573, 2868, 1956, 2079, 3827, 12191, 3695, 18, 4914, 2894, 2311, 6920, 18, 3]}, "items": [{"id": "p_2705", "content": "Pergolide [SEP] A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some mar", "score": 1, "type": null, "tokenized_content": [2, 2079, 3827, 12191, 3695, 3, 43, 2815, 17, 8290, 7964, 7829, 2154, 2258, 2252, 2251, 1942, 2297, 10124, 2573, 1930, 4194, 15743, 11686, 3847, 2308, 19540, 2037, 2673, 3684, 3]}]}
{"query": {"id": "q_2706", "content": "Valvular heart abnormalities [SEP] Valvular heart abnormalities have been reported in patients with Parkinson's disease (PD) tr", "tokenized_content": [2, 25025, 4003, 6754, 3, 25025, 4003, 6754, 2162, 2252, 2568, 1922, 2132, 1956, 10124, 11, 61, 2573, 12, 3203, 13, 2025, 3]}, "items": [{"id": "p_2706", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_2707", "content": "Parkinson's disease [SEP] alvular heart abnormalities have been reported in patients with Parkinson's disease (PD) treated with pergolide. However, the incidence and severit", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 28374, 2168, 4003, 6754, 2162, 2252, 2568, 1922, 2132, 1956, 10124, 11, 61, 2573, 12, 3203, 13, 2868, 1956, 2079, 3827, 12191, 3695, 18, 2406, 3]}, "items": [{"id": "p_2707", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2708", "content": "PD [SEP] lities have been reported in patients with Parkinson's disease (PD) treated with pergolide. However, the incidence and severity of", "tokenized_content": [2, 3203, 3, 4471, 2062, 2162, 2252, 2568, 1922, 2132, 1956, 10124, 11, 61, 2573, 12, 3203, 13, 2868, 1956, 2079, 3827, 12191, 3695, 18, 2406, 16, 1920, 4332, 1930, 5155, 3]}, "items": [{"id": "p_2708", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2709", "content": "pergolide [SEP] reported in patients with Parkinson's disease (PD) treated with pergolide. However, the incidence and severity of these abnormalities var", "tokenized_content": [2, 2079, 3827, 12191, 3695, 3, 2568, 1922, 2132, 1956, 10124, 11, 61, 2573, 12, 3203, 13, 2868, 1956, 2079, 3827, 12191, 3695, 18, 2406, 16, 1920, 4332, 1930, 5155, 1927, 3]}, "items": [{"id": "p_2709", "content": "Pergolide [SEP] A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some mar", "score": 1, "type": null, "tokenized_content": [2, 2079, 3827, 12191, 3695, 3, 43, 2815, 17, 8290, 7964, 7829, 2154, 2258, 2252, 2251, 1942, 2297, 10124, 2573, 1930, 4194, 15743, 11686, 3847, 2308, 19540, 2037, 2673, 3684, 3]}]}
{"query": {"id": "q_2710", "content": "valvular heart abnormality [SEP] assessed. OBJECTIVES: To estimate the frequency and severity of valvular heart abnormality and its possible reversibility after drug withdrawal in a case-", "tokenized_content": [2, 25025, 4003, 14311, 3, 3683, 18, 7634, 30, 1942, 5383, 1920, 3528, 1930, 5155, 1927, 25025, 4003, 14311, 1930, 2496, 3216, 28464, 2256, 2838, 9594, 1922, 43, 3087, 17, 3]}, "items": [{"id": "p_2710", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_2711", "content": "aortic regurgitation [SEP] ed to the cardiology department. RESULTS: Compared to controls, aortic regurgitation (OR: 3.1; 95% IC: 1.1-8.8) and mitral regurgitation (OR: 10.7; ", "tokenized_content": [2, 7677, 20198, 3, 3347, 1942, 1920, 21640, 6143, 18, 2274, 30, 2452, 1942, 3562, 16, 7677, 20198, 12, 2014, 30, 23, 18, 21, 31, 3002, 9, 3996, 30, 21, 18, 3]}, "items": [{"id": "p_2711", "content": "Aortic Valve Insufficiency [SEP] Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to ", "score": 1, "type": null, "tokenized_content": [2, 7677, 9509, 14566, 3, 6598, 2625, 4378, 2007, 1920, 3231, 9893, 1927, 2877, 2037, 1920, 15871, 11859, 3231, 2460, 1920, 3506, 11887, 16, 4523, 1942, 3]}]}
{"query": {"id": "q_2712", "content": "mitral regurgitation [SEP] o controls, aortic regurgitation (OR: 3.1; 95% IC: 1.1-8.8) and mitral regurgitation (OR: 10.7; 95% IC: 2.1-53) were more frequent in PD patients (t", "tokenized_content": [2, 13868, 20198, 3, 57, 3562, 16, 7677, 20198, 12, 2014, 30, 23, 18, 21, 31, 3002, 9, 3996, 30, 21, 18, 21, 17, 28, 18, 28, 13, 1930, 13868, 20198, 3]}, "items": [{"id": "p_2712", "content": "Mitral Valve Insufficiency [SEP] Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mi", "score": 1, "type": null, "tokenized_content": [2, 13868, 9509, 14566, 3, 3231, 9893, 1927, 2877, 2037, 1920, 3506, 11887, 2460, 1920, 3506, 20548, 2810, 1942, 23344, 10408, 1927, 1920, 13868, 9509, 18, 2052, 2112, 2949, 1942, 6519, 3]}]}
{"query": {"id": "q_2713", "content": "valvular regurgitation [SEP] elated with pergolide cumulative dose. A restrictive pattern of valvular regurgitation, suggestive of the role of pergolide, was observed in 12/30 (40", "tokenized_content": [2, 25025, 20198, 3, 2349, 1981, 1956, 2079, 3827, 12191, 3695, 8274, 3253, 18, 43, 18567, 3114, 1927, 25025, 20198, 16, 12855, 1927, 1920, 2770, 1927, 2079, 3827, 12191, 3695, 16, 3]}, "items": [{"id": "p_2713", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_2714", "content": "heart failure [SEP] golide, was observed in 12/30 (40%) patients including two with heart failure. Pergolide was discontinued in 10 patients with valvular heart ", "tokenized_content": [2, 4003, 4574, 3, 9173, 2261, 16, 1982, 2528, 1922, 2369, 19, 2627, 12, 3040, 9, 13, 2132, 2710, 2288, 1956, 4003, 4574, 18, 2079, 3827, 12191, 3695, 1982, 16087, 1922, 3]}, "items": [{"id": "p_2714", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_2715", "content": "Pergolide [SEP] erved in 12/30 (40%) patients including two with heart failure. Pergolide was discontinued in 10 patients with valvular heart disease, re", "tokenized_content": [2, 2079, 3827, 12191, 3695, 3, 2668, 2173, 1922, 2369, 19, 2627, 12, 3040, 9, 13, 2132, 2710, 2288, 1956, 4003, 4574, 18, 2079, 3827, 12191, 3695, 1982, 16087, 1922, 2119, 3]}, "items": [{"id": "p_2715", "content": "Pergolide [SEP] A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some mar", "score": 1, "type": null, "tokenized_content": [2, 2079, 3827, 12191, 3695, 3, 43, 2815, 17, 8290, 7964, 7829, 2154, 2258, 2252, 2251, 1942, 2297, 10124, 2573, 1930, 4194, 15743, 11686, 3847, 2308, 19540, 2037, 2673, 3684, 3]}]}
{"query": {"id": "q_2716", "content": "valvular heart disease [SEP] h heart failure. Pergolide was discontinued in 10 patients with valvular heart disease, resulting in a lower regurgitation grade (p=0.01) at the secon", "tokenized_content": [2, 25025, 4003, 2573, 3, 50, 4003, 4574, 18, 2079, 3827, 12191, 3695, 1982, 16087, 1922, 2119, 2132, 1956, 25025, 4003, 2573, 16, 3864, 1922, 43, 2826, 20198, 4927, 12, 58, 3]}, "items": [{"id": "p_2716", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_2717", "content": "valve regurgitation [SEP] mination. This study supports the high frequency of restrictive valve regurgitation in PD patients treated with pergolide and reveals that a signif", "tokenized_content": [2, 9509, 20198, 3, 2360, 1943, 18, 2052, 2161, 7825, 1920, 2149, 3528, 1927, 18567, 9509, 20198, 1922, 3203, 2132, 2868, 1956, 2079, 3827, 12191, 3695, 1930, 9179, 1988, 43, 2105, 3]}, "items": [{"id": "p_2717", "content": "Heart Valve Diseases [SEP] Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE T", "score": 1, "type": null, "tokenized_content": [2, 4003, 9509, 3902, 3, 6598, 2961, 5884, 2967, 1927, 1920, 3425, 4003, 19335, 1930, 1920, 2458, 4061, 12, 15787, 7848, 1930, 22015, 3336, 62, 3]}]}
{"query": {"id": "q_2718", "content": "dopamine [SEP] provement is usual when the treatment is converted to non-ergot dopamine agonists.", "tokenized_content": [2, 7964, 3, 11948, 2017, 1977, 10616, 2469, 1920, 2311, 1977, 9076, 1942, 2447, 17, 11949, 1991, 7964, 9849, 18, 3]}, "items": [{"id": "p_2718", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2719", "content": "papaverine [SEP] Adverse effects of topical papaverine on auditory nerve function.", "tokenized_content": [2, 3860, 14666, 2053, 3, 5246, 2564, 1927, 12259, 3860, 14666, 2053, 1990, 8401, 5507, 2347, 18, 3]}, "items": [{"id": "p_2719", "content": "Papaverine [SEP] An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It ", "score": 1, "type": null, "tokenized_content": [2, 3860, 14666, 2053, 3, 1925, 29951, 2435, 1922, 7976, 1989, 2308, 2084, 6538, 2712, 1942, 1920, 2303, 7976, 1989, 22390, 1922, 2496, 3170, 2014, 7683, 7728, 18, 2176, 3]}]}
{"query": {"id": "q_2720", "content": "Papaverine hydrochloride [SEP] BACKGROUND: Papaverine hydrochloride is a direct-acting vasodilator used to manage vasospasm during ", "tokenized_content": [2, 3860, 14666, 2053, 16675, 3, 3872, 30, 3860, 14666, 2053, 16675, 1977, 43, 3083, 17, 8290, 28194, 2251, 1942, 12193, 22866, 3508, 2691, 2409, 3]}, "items": [{"id": "p_2720", "content": "Papaverine [SEP] An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It ", "score": 1, "type": null, "tokenized_content": [2, 3860, 14666, 2053, 3, 1925, 29951, 2435, 1922, 7976, 1989, 2308, 2084, 6538, 2712, 1942, 1920, 2303, 7976, 1989, 22390, 1922, 2496, 3170, 2014, 7683, 7728, 18, 2176, 3]}]}
{"query": {"id": "q_2721", "content": "vasospasm [SEP] ine hydrochloride is a direct-acting vasodilator used to manage vasospasm during various neurosurgical operations. Transient cranial nerv", "tokenized_content": [2, 22866, 3508, 2691, 3, 11116, 16675, 1977, 43, 3083, 17, 8290, 28194, 2251, 1942, 12193, 22866, 3508, 2691, 2409, 3425, 29522, 11719, 18, 6809, 13598, 7342, 3]}, "items": [{"id": "p_2721", "content": "Vasospasm, Intracranial [SEP] Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Int", "score": 1, "type": null, "tokenized_content": [2, 22866, 3508, 2691, 16, 12179, 3, 19837, 1927, 9345, 1922, 1920, 13682, 2810, 1942, 12446, 16, 11707, 16, 1930, 3868, 7733, 6689, 3760, 8332, 1922, 2877, 7208, 18, 2218, 3]}]}
{"query": {"id": "q_2722", "content": "cranial nerve dysfunction [SEP] ge vasospasm during various neurosurgical operations. Transient cranial nerve dysfunction has been described in a few cases with topical papaverine. This", "tokenized_content": [2, 13598, 5507, 5273, 3, 3929, 22866, 3508, 2691, 2409, 3425, 29522, 11719, 18, 6809, 13598, 5507, 5273, 2258, 2252, 2910, 1922, 43, 3855, 2919, 1956, 12259, 3860, 14666, 2053, 18, 3]}, "items": [{"id": "p_2722", "content": "Cranial Nerve Diseases [SEP] Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disor", "score": 1, "type": null, "tokenized_content": [2, 13598, 5507, 3902, 3, 4414, 1927, 2340, 2014, 2253, 1927, 1920, 12367, 13598, 12014, 18, 1956, 1920, 7541, 1927, 1920, 10109, 1930, 11284, 12014, 16, 2052, 5921, 2054, 1924, 3]}]}
{"query": {"id": "q_2723", "content": "papaverine [SEP] erve dysfunction has been described in a few cases with topical papaverine. This study supports previous reports and provides neurophysiol", "tokenized_content": [2, 3860, 14666, 2053, 3, 2668, 1961, 5273, 2258, 2252, 2910, 1922, 43, 3855, 2919, 1956, 12259, 3860, 14666, 2053, 18, 2052, 2161, 7825, 2555, 4710, 1930, 4558, 16916, 11149, 3]}, "items": [{"id": "p_2723", "content": "Papaverine [SEP] An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It ", "score": 1, "type": null, "tokenized_content": [2, 3860, 14666, 2053, 3, 1925, 29951, 2435, 1922, 7976, 1989, 2308, 2084, 6538, 2712, 1942, 1920, 2303, 7976, 1989, 22390, 1922, 2496, 3170, 2014, 7683, 7728, 18, 2176, 3]}]}
{"query": {"id": "q_2724", "content": "sensorineural hearing loss [SEP] atient showed no recovery of later waves and a delayed profound sensorineural hearing loss. The average recovery time of BAEP waveforms to pre-papaverine ", "tokenized_content": [2, 6443, 2053, 2741, 8512, 3257, 3, 2019, 3660, 2594, 2239, 5241, 1927, 3690, 10826, 1930, 43, 7083, 11098, 6443, 2053, 2741, 8512, 3257, 18, 1920, 3361, 5241, 2367, 1927, 6813, 3]}, "items": [{"id": "p_2724", "content": "Hearing Loss, Sensorineural [SEP] Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 6443, 2053, 2741, 3, 8512, 3257, 3864, 2037, 4293, 1942, 1920, 23310, 1930, 1920, 6443, 2053, 2741, 5362, 2154, 14958, 23125, 6844, 1920, 22584, 1930, 7464, 3]}]}
{"query": {"id": "q_2725", "content": "adverse effect on the proximal eighth nerve [SEP]  waveforms with a consistent temporal delay suggests a possible adverse effect on the proximal eighth nerve. Recommendations to avoid potential cranial nerve deficits from", "tokenized_content": [2, 5246, 2495, 1990, 1920, 6863, 28743, 5507, 3, 20147, 1956, 43, 3499, 5338, 4989, 4015, 43, 3216, 5246, 2495, 1990, 1920, 6863, 28743, 5507, 18, 7578, 1942, 5161, 2889, 13598, 3]}, "items": [{"id": "p_2725", "content": "Vestibulocochlear Nerve Diseases [SEP] Pathological processes of the VESTIBULOCOCHLEAR NERVE, including the branches of COCHLEAR NERVE and VESTIBULAR NERVE. Common exa", "score": 1, "type": null, "tokenized_content": [2, 14008, 1944, 6158, 7806, 2138, 5507, 3902, 3, 6598, 4028, 1927, 1920, 14008, 1944, 6158, 7806, 2138, 5507, 16, 2710, 1920, 11208, 1927, 15865, 5507, 1930, 15752, 5507, 18, 3059, 1975, 1019, 3]}]}
{"query": {"id": "q_2726", "content": "cranial nerve deficits [SEP] n the proximal eighth nerve. Recommendations to avoid potential cranial nerve deficits from papaverine are provided.", "tokenized_content": [2, 13598, 5507, 7961, 3, 56, 1920, 6863, 28743, 5507, 18, 7578, 1942, 5161, 2889, 13598, 5507, 7961, 2037, 3860, 14666, 2053, 2032, 3675, 18, 3]}, "items": [{"id": "p_2726", "content": "Cranial Nerve Diseases [SEP] Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disor", "score": 1, "type": null, "tokenized_content": [2, 13598, 5507, 3902, 3, 4414, 1927, 2340, 2014, 2253, 1927, 1920, 12367, 13598, 12014, 18, 1956, 1920, 7541, 1927, 1920, 10109, 1930, 11284, 12014, 16, 2052, 5921, 2054, 1924, 3]}]}
{"query": {"id": "q_2727", "content": "proteinuria [SEP] Massive proteinuria and acute renal failure after oral bisphosphonate (alendronate)", "tokenized_content": [2, 15831, 3, 12944, 15831, 1930, 3939, 4604, 4574, 2256, 4726, 16982, 8870, 12, 19543, 10249, 20161, 13, 3]}, "items": [{"id": "p_2727", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2728", "content": "acute renal failure [SEP] Massive proteinuria and acute renal failure after oral bisphosphonate (alendronate) administration in a pat", "tokenized_content": [2, 3939, 4604, 4574, 3, 12944, 15831, 1930, 3939, 4604, 4574, 2256, 4726, 16982, 8870, 12, 19543, 10249, 20161, 13, 4183, 1922, 43, 2917, 3]}, "items": [{"id": "p_2728", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_2729", "content": "bisphosphonate [SEP] Massive proteinuria and acute renal failure after oral bisphosphonate (alendronate) administration in a patient with focal segmental ", "tokenized_content": [2, 16982, 8870, 3, 12944, 15831, 1930, 3939, 4604, 4574, 2256, 4726, 16982, 8870, 12, 19543, 10249, 20161, 13, 4183, 1922, 43, 2774, 1956, 8083, 16294, 3]}, "items": [{"id": "p_2729", "content": "Diphosphonates [SEP] Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium", "score": 1, "type": null, "tokenized_content": [2, 11791, 2609, 23090, 3, 6805, 4300, 2154, 5531, 58, 17, 45, 17, 58, 9031, 16, 2597, 58, 17933, 1958, 8078, 5791, 1918, 2014, 8078, 19730, 4576, 18, 2144, 4300, 4081, 5016, 3]}]}
{"query": {"id": "q_2730", "content": "alendronate [SEP]  proteinuria and acute renal failure after oral bisphosphonate (alendronate) administration in a patient with focal segmental glomeruloscle", "tokenized_content": [2, 19543, 10249, 20161, 3, 15831, 1930, 3939, 4604, 4574, 2256, 4726, 16982, 8870, 12, 19543, 10249, 20161, 13, 4183, 1922, 43, 2774, 1956, 8083, 16294, 19268, 21624, 1952, 3]}, "items": [{"id": "p_2730", "content": "Alendronate [SEP] A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring som", "score": 1, "type": null, "tokenized_content": [2, 19543, 10249, 20161, 3, 43, 16925, 2076, 2996, 6093, 1958, 1920, 2311, 1927, 14285, 12340, 1922, 3089, 18, 2052, 2838, 28315, 4097, 3622, 16, 20174, 5714, 3]}]}
{"query": {"id": "q_2731", "content": "focal segmental glomerulosclerosis [SEP] l bisphosphonate (alendronate) administration in a patient with focal segmental glomerulosclerosis.", "tokenized_content": [2, 8083, 16294, 19268, 25081, 3, 54, 16982, 8870, 12, 19543, 10249, 20161, 13, 4183, 1922, 43, 2774, 1956, 8083, 16294, 19268, 25081, 18, 3]}, "items": [{"id": "p_2731", "content": "Glomerulosclerosis, Focal Segmental [SEP] A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary", "score": 1, "type": null, "tokenized_content": [2, 19268, 25081, 16, 8083, 16294, 3, 43, 17828, 4741, 2014, 4785, 2576, 1958, 43, 2601, 1927, 11655, 4047, 1988, 2258, 3137, 5092, 16, 3065, 2014, 4067, 3]}]}
{"query": {"id": "q_2732", "content": "nephrotic syndrome [SEP] A 61-year-old Japanese man with nephrotic syndrome due to focal segmental glomerulosclerosis was initially respond", "tokenized_content": [2, 29646, 4741, 3, 43, 5473, 17, 2476, 17, 4156, 10405, 2323, 1956, 29646, 4741, 2810, 1942, 8083, 16294, 19268, 25081, 1982, 6370, 4409, 3]}, "items": [{"id": "p_2732", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_2733", "content": "focal segmental glomerulosclerosis [SEP] A 61-year-old Japanese man with nephrotic syndrome due to focal segmental glomerulosclerosis was initially responding well to steroid therapy. The amount of", "tokenized_content": [2, 8083, 16294, 19268, 25081, 3, 43, 5473, 17, 2476, 17, 4156, 10405, 2323, 1956, 29646, 4741, 2810, 1942, 8083, 16294, 19268, 25081, 1982, 6370, 10884, 2486, 1942, 9507, 3181, 18, 3]}, "items": [{"id": "p_2733", "content": "Glomerulosclerosis, Focal Segmental [SEP] A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary", "score": 1, "type": null, "tokenized_content": [2, 19268, 25081, 16, 8083, 16294, 3, 43, 17828, 4741, 2014, 4785, 2576, 1958, 43, 2601, 1927, 11655, 4047, 1988, 2258, 3137, 5092, 16, 3065, 2014, 4067, 3]}]}
{"query": {"id": "q_2734", "content": "steroid [SEP] l segmental glomerulosclerosis was initially responding well to steroid therapy. The amount of daily urinary protein decreased from 15.", "tokenized_content": [2, 9507, 3, 54, 16294, 19268, 25081, 1982, 6370, 10884, 2486, 1942, 9507, 3181, 18, 1920, 4351, 1927, 4692, 7075, 2213, 3261, 2037, 2461, 18, 3]}, "items": [{"id": "p_2734", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_2735", "content": "bisphosphonate [SEP] rotein decreased from 15.6 to 2.8 g. Within 14 days of the oral bisphosphonate (alendronate sodium) administration, the amount of daily urinar", "tokenized_content": [2, 16982, 8870, 3, 5337, 14818, 3261, 2037, 2461, 18, 26, 1942, 22, 18, 28, 49, 18, 2651, 2607, 3000, 1927, 1920, 4726, 16982, 8870, 12, 19543, 10249, 20161, 5227, 13, 3]}, "items": [{"id": "p_2735", "content": "Diphosphonates [SEP] Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium", "score": 1, "type": null, "tokenized_content": [2, 11791, 2609, 23090, 3, 6805, 4300, 2154, 5531, 58, 17, 45, 17, 58, 9031, 16, 2597, 58, 17933, 1958, 8078, 5791, 1918, 2014, 8078, 19730, 4576, 18, 2144, 4300, 4081, 5016, 3]}]}
{"query": {"id": "q_2736", "content": "alendronate sodium [SEP]  from 15.6 to 2.8 g. Within 14 days of the oral bisphosphonate (alendronate sodium) administration, the amount of daily urinary protein increased ", "tokenized_content": [2, 19543, 10249, 20161, 5227, 3, 2037, 2461, 18, 26, 1942, 22, 18, 28, 49, 18, 2651, 2607, 3000, 1927, 1920, 4726, 16982, 8870, 12, 19543, 10249, 20161, 5227, 13, 4183, 3]}, "items": [{"id": "p_2736", "content": "Alendronate [SEP] A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring som", "score": 1, "type": null, "tokenized_content": [2, 19543, 10249, 20161, 3, 43, 16925, 2076, 2996, 6093, 1958, 1920, 2311, 1927, 14285, 12340, 1922, 3089, 18, 2052, 2838, 28315, 4097, 3622, 16, 20174, 5714, 3]}]}
{"query": {"id": "q_2737", "content": "acute renal failure [SEP] nt of daily urinary protein increased rapidly up to 12.8 g with acute renal failure. After discontinuing the oral alendronate, the patient underwen", "tokenized_content": [2, 3939, 4604, 4574, 3, 5891, 1927, 4692, 7075, 2213, 2502, 6221, 2353, 1942, 2369, 18, 28, 49, 1956, 3939, 4604, 4574, 18, 2256, 9035, 13768, 1920, 4726, 19543, 10249, 20161, 3]}, "items": [{"id": "p_2737", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_2738", "content": "alendronate [SEP]  from 15.6 to 2.8 g. Within 14 days of the oral bisphosphonate (alendronate sodium) administration, the amount of daily urinary protein inc", "tokenized_content": [2, 19543, 10249, 20161, 3, 2037, 2461, 18, 26, 1942, 22, 18, 28, 49, 18, 2651, 2607, 3000, 1927, 1920, 4726, 16982, 8870, 12, 19543, 10249, 20161, 5227, 13, 4183, 16, 3]}, "items": [{"id": "p_2738", "content": "Alendronate [SEP] A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring som", "score": 1, "type": null, "tokenized_content": [2, 19543, 10249, 20161, 3, 43, 16925, 2076, 2996, 6093, 1958, 1920, 2311, 1927, 14285, 12340, 1922, 3089, 18, 2052, 2838, 28315, 4097, 3622, 16, 20174, 5714, 3]}]}
{"query": {"id": "q_2739", "content": "creatinine [SEP] ysis and four cycles of LDL apheresis. Urinary volume and serum creatinine levels recovered to the normal range, with urinary protein disa", "tokenized_content": [2, 9374, 3, 24018, 1937, 1930, 3006, 6355, 1927, 8017, 12274, 10008, 1937, 18, 7075, 3776, 1930, 3256, 9374, 2428, 8294, 1942, 1920, 2791, 3109, 16, 1956, 7075, 2213, 2054, 1019, 3]}, "items": [{"id": "p_2739", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_2740", "content": "bisphosphonates [SEP] is report demonstrates that not only intravenous, but also oral bisphosphonates can aggravate proteinuria and acute renal failure.", "tokenized_content": [2, 28824, 3, 1977, 3809, 7706, 1988, 2084, 2444, 7307, 16, 2308, 2222, 4726, 28824, 2112, 18206, 2010, 15831, 1930, 3939, 4604, 4574, 18, 3]}, "items": [{"id": "p_2740", "content": "Diphosphonates [SEP] Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium", "score": 1, "type": null, "tokenized_content": [2, 11791, 2609, 23090, 3, 6805, 4300, 2154, 5531, 58, 17, 45, 17, 58, 9031, 16, 2597, 58, 17933, 1958, 8078, 5791, 1918, 2014, 8078, 19730, 4576, 18, 2144, 4300, 4081, 5016, 3]}]}
{"query": {"id": "q_2741", "content": "proteinuria [SEP] t only intravenous, but also oral bisphosphonates can aggravate proteinuria and acute renal failure.", "tokenized_content": [2, 15831, 3, 62, 2444, 7307, 16, 2308, 2222, 4726, 28824, 2112, 18206, 2010, 15831, 1930, 3939, 4604, 4574, 18, 3]}, "items": [{"id": "p_2741", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2742", "content": "doxorubicin [SEP] Serum- and glucocorticoid-inducible kinase 1 in doxorubicin-induced nephrotic syndrome.", "tokenized_content": [2, 12377, 3, 3256, 17, 1930, 14469, 17, 9376, 4016, 21, 1922, 12377, 17, 2719, 29646, 4741, 18, 3]}, "items": [{"id": "p_2742", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2743", "content": "nephrotic syndrome [SEP] m- and glucocorticoid-inducible kinase 1 in doxorubicin-induced nephrotic syndrome.", "tokenized_content": [2, 29646, 4741, 3, 55, 17, 1930, 14469, 17, 9376, 4016, 21, 1922, 12377, 17, 2719, 29646, 4741, 18, 3]}, "items": [{"id": "p_2743", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_2744", "content": "Doxorubicin [SEP] Doxorubicin-induced nephropathy leads to epithelial sodium channel (ENaC)-d", "tokenized_content": [2, 12377, 3, 12377, 17, 2719, 15582, 5029, 1942, 4944, 5227, 4999, 12, 24971, 13, 17, 46, 3]}, "items": [{"id": "p_2744", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2745", "content": "nephropathy [SEP] Doxorubicin-induced nephropathy leads to epithelial sodium channel (ENaC)-dependent volume rete", "tokenized_content": [2, 15582, 3, 12377, 17, 2719, 15582, 5029, 1942, 4944, 5227, 4999, 12, 24971, 13, 17, 3100, 3776, 3172, 1021, 3]}, "items": [{"id": "p_2745", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2746", "content": "sodium [SEP] Doxorubicin-induced nephropathy leads to epithelial sodium channel (ENaC)-dependent volume retention and renal fibrosis. T", "tokenized_content": [2, 5227, 3, 12377, 17, 2719, 15582, 5029, 1942, 4944, 5227, 4999, 12, 24971, 13, 17, 3100, 3776, 7521, 1930, 4604, 6769, 18, 62, 3]}, "items": [{"id": "p_2746", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_2747", "content": "volume retention [SEP] nephropathy leads to epithelial sodium channel (ENaC)-dependent volume retention and renal fibrosis. The aldosterone-sensitive serum- and glucoc", "tokenized_content": [2, 3776, 7521, 3, 15582, 5029, 1942, 4944, 5227, 4999, 12, 24971, 13, 17, 3100, 3776, 7521, 1930, 4604, 6769, 18, 1920, 16944, 17, 4532, 3256, 17, 1930, 3351, 1994, 3]}, "items": [{"id": "p_2747", "content": "Urinary Retention [SEP] Inability to empty the URINARY BLADDER with voiding (URINATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7521, 3, 11752, 1942, 10494, 1920, 7075, 7821, 1956, 27682, 12, 3674, 2636, 13, 18, 3]}]}
{"query": {"id": "q_2748", "content": "fibrosis [SEP] lial sodium channel (ENaC)-dependent volume retention and renal fibrosis. The aldosterone-sensitive serum- and glucocorticoid-inducible ", "tokenized_content": [2, 6769, 3, 25700, 1024, 5227, 4999, 12, 24971, 13, 17, 3100, 3776, 7521, 1930, 4604, 6769, 18, 1920, 16944, 17, 4532, 3256, 17, 1930, 14469, 17, 9376, 3]}, "items": [{"id": "p_2748", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_2749", "content": "aldosterone [SEP] annel (ENaC)-dependent volume retention and renal fibrosis. The aldosterone-sensitive serum- and glucocorticoid-inducible kinase SGK1 has b", "tokenized_content": [2, 16944, 3, 5112, 1938, 12, 24971, 13, 17, 3100, 3776, 7521, 1930, 4604, 6769, 18, 1920, 16944, 17, 4532, 3256, 17, 1930, 14469, 17, 9376, 4016, 10075, 4835, 2258, 44, 3]}, "items": [{"id": "p_2749", "content": "Aldosterone [SEP] A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodiu", "score": 1, "type": null, "tokenized_content": [2, 16944, 3, 43, 6365, 8366, 2007, 1920, 10651, 4997, 1988, 7014, 15428, 1930, 3224, 6766, 2007, 3605, 1920, 4604, 7521, 1927, 4546, 1033, 1032, 3]}]}
{"query": {"id": "q_2750", "content": "nephrotic syndrome [SEP] te the role of SGK1 in the volume retention and fibrosis during nephrotic syndrome. To this end, doxorubicin (15 mug/g body wt) was injected intra", "tokenized_content": [2, 29646, 4741, 3, 3602, 1920, 2770, 1927, 10075, 4835, 1922, 1920, 3776, 7521, 1930, 6769, 2409, 29646, 4741, 18, 1942, 2052, 2482, 16, 12377, 12, 2461, 28991, 19, 49, 3362, 3]}, "items": [{"id": "p_2750", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_2751", "content": "doxorubicin [SEP]  retention and fibrosis during nephrotic syndrome. To this end, doxorubicin (15 mug/g body wt) was injected intravenously into gene-targete", "tokenized_content": [2, 12377, 3, 7521, 1930, 6769, 2409, 29646, 4741, 18, 1942, 2052, 2482, 16, 12377, 12, 2461, 28991, 19, 49, 3362, 3751, 13, 1982, 5624, 15132, 2460, 2359, 17, 2758, 1021, 3]}, "items": [{"id": "p_2751", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2752", "content": "proteinuria [SEP] ittermates (sgk1(+/+)). Doxorubicin treatment resulted in heavy proteinuria (>100 mg protein/mg crea) in 15/44 of sgk1(+/+) and 15/44 of sg", "tokenized_content": [2, 15831, 3, 24930, 2166, 2209, 12, 10075, 4835, 12, 15, 19, 15, 13, 13, 18, 12377, 2311, 4306, 1922, 7881, 15831, 12, 34, 2813, 2786, 2213, 19, 2786, 3478, 1019, 3]}, "items": [{"id": "p_2752", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2753", "content": "ascites [SEP] /44 of sgk1(-/-) mice leading to severe nephrotic syndrome with ascites, lipidemia, and hypoalbuminemia in both genotypes. Plasma aldos", "tokenized_content": [2, 17622, 3, 19, 4044, 1927, 10075, 4835, 12, 17, 19, 17, 13, 2518, 4523, 1942, 4010, 29646, 4741, 1956, 17622, 16, 4486, 3847, 16, 1930, 14395, 15721, 3847, 1922, 2321, 3]}, "items": [{"id": "p_2753", "content": "Ascites [SEP] Accumulation or retention of free fluid within the peritoneal cavity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17622, 3, 4858, 2014, 7521, 1927, 3294, 5466, 2651, 1920, 10706, 8568, 18, 3]}]}
{"query": {"id": "q_2754", "content": "lipidemia [SEP] k1(-/-) mice leading to severe nephrotic syndrome with ascites, lipidemia, and hypoalbuminemia in both genotypes. Plasma aldosterone leve", "tokenized_content": [2, 4486, 3847, 3, 16185, 12, 17, 19, 17, 13, 2518, 4523, 1942, 4010, 29646, 4741, 1956, 17622, 16, 4486, 3847, 16, 1930, 14395, 15721, 3847, 1922, 2321, 7059, 18, 3582, 3]}, "items": [{"id": "p_2754", "content": "Hyperlipidemias [SEP] Conditions with excess LIPIDS in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21381, 1036, 3, 2961, 1956, 5799, 8238, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_2755", "content": "hypoalbuminemia [SEP] ading to severe nephrotic syndrome with ascites, lipidemia, and hypoalbuminemia in both genotypes. Plasma aldosterone levels increased in nephr", "tokenized_content": [2, 14395, 15721, 3847, 3, 2041, 1941, 1942, 4010, 29646, 4741, 1956, 17622, 16, 4486, 3847, 16, 1930, 14395, 15721, 3847, 1922, 2321, 7059, 18, 3582, 16944, 2428, 2502, 1922, 7737, 3]}, "items": [{"id": "p_2755", "content": "Hypoalbuminemia [SEP] A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased h", "score": 1, "type": null, "tokenized_content": [2, 14395, 15721, 3847, 3, 43, 2625, 1922, 2154, 7712, 2237, 1922, 2877, 12, 3256, 7712, 13, 1977, 4535, 1920, 2791, 3109, 18, 14395, 15721, 3847, 2278, 1998, 2810, 1942, 3261, 50, 3]}]}
{"query": {"id": "q_2756", "content": "nephrotic [SEP] te the role of SGK1 in the volume retention and fibrosis during nephrotic syndrome. To this end, doxorubicin (15 mug/g body wt) was injec", "tokenized_content": [2, 29646, 3, 3602, 1920, 2770, 1927, 10075, 4835, 1922, 1920, 3776, 7521, 1930, 6769, 2409, 29646, 4741, 18, 1942, 2052, 2482, 16, 12377, 12, 2461, 28991, 19, 49, 3362, 3751, 3]}, "items": [{"id": "p_2756", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_2757", "content": "weight gain [SEP] ol/mg crea) and was associated with a significantly higher body weight gain in sgk1(+/+) compared with sgk1(-/-) mice (+6.6 +/- 0.7 vs. +4.", "tokenized_content": [2, 3388, 5938, 3, 2865, 19, 2786, 3478, 1019, 13, 1930, 1982, 2458, 1956, 43, 2567, 2580, 3362, 3388, 5938, 1922, 10075, 4835, 12, 15, 19, 15, 13, 2452, 1956, 10075, 3]}, "items": [{"id": "p_2757", "content": "Weight Gain [SEP] Increase in BODY WEIGHT over existing weight.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3388, 5938, 3, 2760, 1922, 3362, 3388, 2338, 6124, 3388, 18, 3]}]}
{"query": {"id": "q_2758", "content": "urea [SEP] +4.1 +/- 0.8 g). During the course of nephrotic syndrome, serum urea concentrations increased significantly faster in sgk1(-/-) mice", "tokenized_content": [2, 10505, 3, 15, 24, 18, 21, 15, 19, 17, 20, 18, 28, 49, 13, 18, 2409, 1920, 4914, 1927, 29646, 4741, 16, 3256, 10505, 3295, 2502, 2567, 8411, 1922, 10075, 3]}, "items": [{"id": "p_2758", "content": "Urea [SEP] A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of prote", "score": 1, "type": null, "tokenized_content": [2, 10505, 3, 43, 3547, 5333, 1922, 1920, 3568, 2037, 14880, 4152, 2007, 1920, 30097, 8547, 1943, 1927, 3835, 4576, 18, 2176, 1977, 1920, 7944, 2482, 4863, 1927, 2174, 3]}]}
{"query": {"id": "q_2759", "content": "uremia [SEP] ntly faster in sgk1(-/-) mice than in sgk1(+/+) mice leading to uremia and a reduced median survival in sgk1(-/-) mice (29 vs. 40 days", "tokenized_content": [2, 6794, 6026, 3, 5891, 1954, 8411, 1922, 10075, 4835, 12, 17, 19, 17, 13, 2518, 2254, 1922, 10075, 4835, 12, 15, 19, 15, 13, 2518, 4523, 1942, 6794, 6026, 1930, 3]}, "items": [{"id": "p_2759", "content": "Uremia [SEP] A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the resul", "score": 1, "type": null, "tokenized_content": [2, 6794, 6026, 3, 43, 2535, 4741, 2458, 1956, 1920, 7521, 1927, 4604, 10437, 4461, 2014, 29870, 13599, 1922, 1920, 2877, 18, 2176, 1977, 5394, 1920, 2164, 3]}]}
{"query": {"id": "q_2760", "content": "cholestasis [SEP] Severe and long lasting cholestasis after high-dose co-trimoxazole treatment for Pneumocystis pneum", "tokenized_content": [2, 30086, 3, 4010, 1930, 2815, 11671, 30086, 2256, 2149, 17, 3253, 2081, 17, 7103, 22498, 2311, 1958, 6097, 22972, 6097, 3]}, "items": [{"id": "p_2760", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_2761", "content": "co-trimoxazole [SEP] Severe and long lasting cholestasis after high-dose co-trimoxazole treatment for Pneumocystis pneumonia in HIV-infected patients--", "tokenized_content": [2, 2081, 17, 7103, 22498, 3, 4010, 1930, 2815, 11671, 30086, 2256, 2149, 17, 3253, 2081, 17, 7103, 22498, 2311, 1958, 6097, 22972, 7868, 1922, 3525, 17, 4014, 2132, 17, 17, 3]}, "items": [{"id": "p_2761", "content": "Trimethoprim-Sulfamethoxazole Combination [SEP] This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gr", "score": 1, "type": null, "tokenized_content": [2, 28323, 17, 5141, 10758, 22498, 3921, 3, 2052, 2838, 3921, 2258, 9534, 1942, 1998, 1925, 3655, 4272, 5899, 1956, 4949, 17, 5648, 13021, 2455, 3316, 2321, 2398, 3]}]}
{"query": {"id": "q_2762", "content": "Pneumocystis pneumonia [SEP] asting cholestasis after high-dose co-trimoxazole treatment for Pneumocystis pneumonia in HIV-infected patients--a report of two cases.", "tokenized_content": [2, 6097, 22972, 7868, 3, 5988, 1941, 30086, 2256, 2149, 17, 3253, 2081, 17, 7103, 22498, 2311, 1958, 6097, 22972, 7868, 1922, 3525, 17, 4014, 2132, 17, 17, 43, 3809, 1927, 3]}, "items": [{"id": "p_2762", "content": "Pneumonia, Pneumocystis [SEP] A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachyp", "score": 1, "type": null, "tokenized_content": [2, 7868, 16, 6097, 22972, 3, 43, 5352, 2573, 1922, 5209, 6966, 1922, 30297, 2014, 3054, 29956, 5270, 2132, 2014, 5969, 16, 4378, 2007, 18461, 16, 12762, 2085, 3]}]}
{"query": {"id": "q_2763", "content": "HIV-infected [SEP] igh-dose co-trimoxazole treatment for Pneumocystis pneumonia in HIV-infected patients--a report of two cases.", "tokenized_content": [2, 3525, 17, 4014, 3, 20733, 17, 3253, 2081, 17, 7103, 22498, 2311, 1958, 6097, 22972, 7868, 1922, 3525, 17, 4014, 2132, 17, 17, 43, 3809, 1927, 2288, 2919, 18, 3]}, "items": [{"id": "p_2763", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_2764", "content": "Pneumocystis pneumonia [SEP] Pneumocystis pneumonia (PCP), a common opportunistic infection in HIV-infected individ", "tokenized_content": [2, 6097, 22972, 7868, 3, 6097, 22972, 7868, 12, 16412, 13, 16, 43, 3059, 19169, 2909, 1922, 3525, 17, 4014, 2692, 3]}, "items": [{"id": "p_2764", "content": "Pneumonia, Pneumocystis [SEP] A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachyp", "score": 1, "type": null, "tokenized_content": [2, 7868, 16, 6097, 22972, 3, 43, 5352, 2573, 1922, 5209, 6966, 1922, 30297, 2014, 3054, 29956, 5270, 2132, 2014, 5969, 16, 4378, 2007, 18461, 16, 12762, 2085, 3]}]}
{"query": {"id": "q_2765", "content": "PCP [SEP] Pneumocystis pneumonia (PCP), a common opportunistic infection in HIV-infected individuals,", "tokenized_content": [2, 16412, 3, 6097, 22972, 7868, 12, 16412, 13, 16, 43, 3059, 19169, 2909, 1922, 3525, 17, 4014, 3445, 16, 3]}, "items": [{"id": "p_2765", "content": "Pneumonia, Pneumocystis [SEP] A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachyp", "score": 1, "type": null, "tokenized_content": [2, 7868, 16, 6097, 22972, 3, 43, 5352, 2573, 1922, 5209, 6966, 1922, 30297, 2014, 3054, 29956, 5270, 2132, 2014, 5969, 16, 4378, 2007, 18461, 16, 12762, 2085, 3]}]}
{"query": {"id": "q_2766", "content": "opportunistic infection [SEP] Pneumocystis pneumonia (PCP), a common opportunistic infection in HIV-infected individuals, is generally treated with high dos", "tokenized_content": [2, 19169, 2909, 3, 6097, 22972, 7868, 12, 16412, 13, 16, 43, 3059, 19169, 2909, 1922, 3525, 17, 4014, 3445, 16, 1977, 4933, 2868, 1956, 2149, 4220, 3]}, "items": [{"id": "p_2766", "content": "Opportunistic Infections [SEP] An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19169, 5024, 3, 1925, 2909, 4189, 2007, 1925, 9669, 2154, 8272, 8070, 2441, 4908, 2961, 16, 47, 18, 49, 18, 16, 2409, 15858, 18, 3]}]}
{"query": {"id": "q_2767", "content": "HIV-infected [SEP] eumocystis pneumonia (PCP), a common opportunistic infection in HIV-infected individuals, is generally treated with high doses of co-trimoxa", "tokenized_content": [2, 3525, 17, 4014, 3, 4791, 12492, 23159, 3600, 7868, 12, 16412, 13, 16, 43, 3059, 19169, 2909, 1922, 3525, 17, 4014, 3445, 16, 1977, 4933, 2868, 1956, 2149, 5312, 1927, 3]}, "items": [{"id": "p_2767", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_2768", "content": "co-trimoxazole [SEP] V-infected individuals, is generally treated with high doses of co-trimoxazole. However, treatment is often limited by adverse effects. Here, ", "tokenized_content": [2, 2081, 17, 7103, 22498, 3, 64, 17, 4014, 3445, 16, 1977, 4933, 2868, 1956, 2149, 5312, 1927, 2081, 17, 7103, 22498, 18, 2406, 16, 2311, 1977, 3868, 3892, 2007, 5246, 3]}, "items": [{"id": "p_2768", "content": "Trimethoprim-Sulfamethoxazole Combination [SEP] This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gr", "score": 1, "type": null, "tokenized_content": [2, 28323, 17, 5141, 10758, 22498, 3921, 3, 2052, 2838, 3921, 2258, 9534, 1942, 1998, 1925, 3655, 4272, 5899, 1956, 4949, 17, 5648, 13021, 2455, 3316, 2321, 2398, 3]}]}
{"query": {"id": "q_2769", "content": "intrahepatic cholestasis [SEP] ly immunocompromised HIV-infected patients who developed severe intrahepatic cholestasis, and in one patient lesions mimicking liver abscess formation o", "tokenized_content": [2, 22323, 30086, 3, 7518, 21134, 3525, 17, 4014, 2132, 2746, 3530, 4010, 22323, 30086, 16, 1930, 1922, 2340, 2774, 4518, 18072, 3568, 14159, 3337, 57, 3]}, "items": [{"id": "p_2769", "content": "Cholestasis, Intrahepatic [SEP] Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPA", "score": 1, "type": null, "tokenized_content": [2, 30086, 16, 22323, 3, 6159, 1927, 9619, 3426, 2810, 1942, 4047, 1942, 1920, 9919, 31, 9619, 11152, 16058, 1033, 31, 2014, 1920, 22323, 9619, 19277, 12, 9619, 19277, 16, 5153, 4116, 4302, 3]}]}
{"query": {"id": "q_2770", "content": "liver abscess [SEP]  intrahepatic cholestasis, and in one patient lesions mimicking liver abscess formation on radiologic exams, during co-trimoxazole treatment ", "tokenized_content": [2, 3568, 14159, 3, 22323, 30086, 16, 1930, 1922, 2340, 2774, 4518, 18072, 3568, 14159, 3337, 1990, 23048, 26510, 16, 2409, 2081, 17, 7103, 22498, 2311, 3]}, "items": [{"id": "p_2770", "content": "Liver Abscess [SEP] Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 14159, 3, 18992, 2014, 3137, 16471, 1927, 24093, 2651, 1920, 3568, 1966, 43, 3211, 1927, 2909, 2007, 4802, 16, 23583, 13642, 1019, 16, 2014, 2303, 4820, 18, 3]}]}
{"query": {"id": "q_2771", "content": "proteinuria [SEP] Clinically significant proteinuria following the administration of sirolimus to renal transplant r", "tokenized_content": [2, 15831, 3, 5908, 2228, 15831, 2894, 1920, 4183, 1927, 4520, 24124, 1942, 4604, 5192, 60, 3]}, "items": [{"id": "p_2771", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2772", "content": "sirolimus [SEP] nically significant proteinuria following the administration of sirolimus to renal transplant recipients.", "tokenized_content": [2, 4520, 24124, 3, 11188, 2169, 2228, 15831, 2894, 1920, 4183, 1927, 4520, 24124, 1942, 4604, 5192, 9336, 18, 3]}, "items": [{"id": "p_2772", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_2773", "content": "Sirolimus [SEP] BACKGROUND: Sirolimus is the latest immunosuppressive agent used to prevent rejection", "tokenized_content": [2, 4520, 24124, 3, 3872, 30, 4520, 24124, 1977, 1920, 16760, 12910, 5899, 2251, 1942, 4625, 10820, 3]}, "items": [{"id": "p_2773", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_2774", "content": "nephrotoxicity [SEP] osuppressive agent used to prevent rejection, and may have less nephrotoxicity than calcineurin inhibitor (CNI)-based regimens. To date there ", "tokenized_content": [2, 27880, 3, 3125, 3481, 5932, 5899, 2251, 1942, 4625, 10820, 16, 1930, 2278, 2162, 2941, 27880, 2254, 19555, 4106, 12, 5940, 1033, 13, 17, 2454, 9922, 18, 1942, 5699, 2276, 3]}, "items": [{"id": "p_2774", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2775", "content": "proteinuria [SEP] e there has been little documentation of clinically significant proteinuria linked with the use of sirolimus. We have encountered several p", "tokenized_content": [2, 15831, 3, 47, 2276, 2258, 2252, 5082, 14924, 1927, 5908, 2228, 15831, 4624, 1956, 1920, 2485, 1927, 4520, 24124, 18, 2038, 2162, 11989, 2980, 58, 3]}, "items": [{"id": "p_2775", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2776", "content": "sirolimus [SEP] on of clinically significant proteinuria linked with the use of sirolimus. We have encountered several patients who developed substantial", "tokenized_content": [2, 4520, 24124, 3, 1990, 1927, 5908, 2228, 15831, 4624, 1956, 1920, 2485, 1927, 4520, 24124, 18, 2038, 2162, 11989, 2980, 2132, 2746, 3530, 6317, 3]}, "items": [{"id": "p_2776", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_2777", "content": "creatinine [SEP] ne samples by turbidometric measurement or random urine protein:creatinine ratios, an estimate of grams of proteinuria/day. Laboratory res", "tokenized_content": [2, 9374, 3, 2069, 2785, 2007, 13840, 15072, 14578, 3133, 4783, 2014, 3332, 6960, 2213, 30, 9374, 5835, 16, 1925, 5383, 1927, 22411, 1927, 15831, 19, 3007, 18, 4542, 1995, 3]}, "items": [{"id": "p_2777", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_2778", "content": "nephrotic [SEP] tion between the initiation of sirolimus and the development of nephrotic-range proteinuria. Proteinuria correlated most strongly with si", "tokenized_content": [2, 29646, 3, 8685, 1916, 2192, 1920, 6035, 1927, 4520, 24124, 1930, 1920, 2740, 1927, 29646, 17, 3109, 15831, 18, 15831, 4374, 2501, 4937, 1956, 5998, 3]}, "items": [{"id": "p_2778", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_2779", "content": "Proteinuria [SEP] f sirolimus and the development of nephrotic-range proteinuria. Proteinuria correlated most strongly with sirolimus therapy when compared t", "tokenized_content": [2, 15831, 3, 48, 4520, 24124, 1930, 1920, 2740, 1927, 29646, 17, 3109, 15831, 18, 15831, 4374, 2501, 4937, 1956, 4520, 24124, 3181, 2469, 2452, 62, 3]}, "items": [{"id": "p_2779", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2780", "content": "oxycodone [SEP] tive cognitive and subjective side effects of immediate-release oxycodone in healthy middle-aged and older adults.", "tokenized_content": [2, 20004, 4879, 28615, 1021, 3, 8685, 1961, 4328, 1930, 9106, 4159, 2564, 1927, 8426, 17, 4012, 20004, 4879, 28615, 1021, 1922, 4097, 5576, 17, 5177, 1930, 4706, 4440, 18, 3]}, "items": [{"id": "p_2780", "content": "Oxycodone [SEP] A semisynthetic derivative of CODEINE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20004, 4879, 28615, 1021, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 7815, 2053, 18, 3]}]}
{"query": {"id": "q_2781", "content": "oxycodone [SEP] rocognitive effects of a single 10-mg dose of immediate-release oxycodone in healthy, older (> 65 years), and middle-aged (35 to 55 years", "tokenized_content": [2, 20004, 4879, 28615, 1021, 3, 10326, 16695, 2564, 1927, 43, 2957, 2119, 17, 2786, 3253, 1927, 8426, 17, 4012, 20004, 4879, 28615, 1021, 1922, 4097, 16, 4706, 12, 34, 4459, 3]}, "items": [{"id": "p_2781", "content": "Oxycodone [SEP] A semisynthetic derivative of CODEINE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20004, 4879, 28615, 1021, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 7815, 2053, 18, 3]}]}
{"query": {"id": "q_2782", "content": "pain [SEP] adults who were not suffering from chronic or significant daily pain. Seventy-one participants completed 2 separate study days and w", "tokenized_content": [2, 3594, 3, 4440, 2746, 1985, 2084, 11364, 2037, 3724, 2014, 2228, 4692, 3594, 18, 16270, 17, 2340, 3003, 5721, 22, 5850, 2161, 3000, 1930, 65, 3]}, "items": [{"id": "p_2782", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2783", "content": "declines in simple and sustained attention [SEP] approximately 90 to 120 minutes postdose (P < .01). Significant declines in simple and sustained attention, working memory, and verbal memory were observed at 1 hour post", "tokenized_content": [2, 15459, 1922, 5288, 1930, 7637, 4976, 3, 3993, 3865, 1942, 6103, 4814, 20527, 2217, 12, 58, 32, 18, 3287, 13, 18, 2228, 15459, 1922, 5288, 1930, 7637, 4976, 16, 5905, 3]}, "items": [{"id": "p_2783", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_2784", "content": "chronic pain [SEP] ggests that for healthy older adults who are not suffering from chronic pain, neurocognitive and pharmacodynamic changes in response to a 10", "tokenized_content": [2, 3724, 3594, 3, 12358, 9820, 1988, 1958, 4097, 4706, 4440, 2746, 2032, 2084, 11364, 2037, 3724, 3594, 16, 18643, 1930, 24358, 2840, 1922, 2644, 1942, 43, 2119, 3]}, "items": [{"id": "p_2784", "content": "Chronic Pain [SEP] Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persi", "score": 1, "type": null, "tokenized_content": [2, 3724, 3594, 3, 3546, 1941, 15826, 1988, 20350, 1958, 2253, 2254, 43, 3855, 3221, 18, 2176, 2278, 2014, 2278, 2084, 1998, 2458, 1956, 7176, 2014, 2573, 16, 1930, 2278, 3096, 1033, 3]}]}
{"query": {"id": "q_2785", "content": "modafinil [SEP] Normalizing effects of modafinil on sleep in chronic cocaine users.", "tokenized_content": [2, 2157, 2624, 11566, 1024, 3, 24202, 2564, 1927, 2157, 2624, 11566, 1024, 1990, 5006, 1922, 3724, 9045, 6603, 18, 3]}, "items": [{"id": "p_2785", "content": "modafinil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2157, 2624, 11566, 1024, 3, 3]}]}
{"query": {"id": "q_2786", "content": "cocaine [SEP] Normalizing effects of modafinil on sleep in chronic cocaine users.", "tokenized_content": [2, 9045, 3, 24202, 2564, 1927, 2157, 2624, 11566, 1024, 1990, 5006, 1922, 3724, 9045, 6603, 18, 3]}, "items": [{"id": "p_2786", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2787", "content": "modafinil [SEP]  the present study was to determine the effect of morning-dosed modafinil on sleep and daytime sleepiness in chronic cocaine users. METHO", "tokenized_content": [2, 2157, 2624, 11566, 1024, 3, 1920, 2481, 2161, 1982, 1942, 3415, 1920, 2495, 1927, 12661, 17, 25922, 2157, 2624, 11566, 1024, 1990, 5006, 1930, 17916, 24157, 1922, 3724, 9045, 6603, 3]}, "items": [{"id": "p_2787", "content": "modafinil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2157, 2624, 11566, 1024, 3, 3]}]}
{"query": {"id": "q_2788", "content": "daytime sleepiness [SEP] to determine the effect of morning-dosed modafinil on sleep and daytime sleepiness in chronic cocaine users. METHOD: Twenty cocaine-dependent part", "tokenized_content": [2, 17916, 24157, 3, 1942, 3415, 1920, 2495, 1927, 12661, 17, 25922, 2157, 2624, 11566, 1024, 1990, 5006, 1930, 17916, 24157, 1922, 3724, 9045, 6603, 18, 2417, 30, 7639, 9045, 17, 3]}, "items": [{"id": "p_2788", "content": "Sleep Disorders [SEP] Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major c", "score": 1, "type": null, "tokenized_content": [2, 5006, 4414, 3, 2961, 4378, 2007, 12654, 1927, 10616, 5006, 4147, 2014, 5888, 18, 5006, 4414, 2278, 1998, 5831, 2460, 2559, 3044, 45, 3]}]}
{"query": {"id": "q_2789", "content": "cocaine [SEP] ning-dosed modafinil on sleep and daytime sleepiness in chronic cocaine users. METHOD: Twenty cocaine-dependent participants were rando", "tokenized_content": [2, 9045, 3, 12117, 1029, 17, 25922, 2157, 2624, 11566, 1024, 1990, 5006, 1930, 17916, 24157, 1922, 3724, 9045, 6603, 18, 2417, 30, 7639, 9045, 17, 3100, 3003, 1985, 3315, 1037, 3]}, "items": [{"id": "p_2789", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_2790", "content": "Modafinil [SEP] malizing effect of modafinil in cocaine-dependent participants. Modafinil was associated with increased daytime sleep latency, as measure", "tokenized_content": [2, 2157, 2624, 11566, 1024, 3, 3054, 3903, 2495, 1927, 2157, 2624, 11566, 1024, 1922, 9045, 17, 3100, 3003, 18, 2157, 2624, 11566, 1024, 1982, 2458, 1956, 2502, 17916, 5006, 9393, 3]}, "items": [{"id": "p_2790", "content": "modafinil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2157, 2624, 11566, 1024, 3, 3]}]}
{"query": {"id": "q_2791", "content": "asenapine [SEP] Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with", "tokenized_content": [2, 28826, 2175, 12184, 3, 4348, 1930, 5407, 1927, 28826, 2175, 12184, 1922, 43, 5936, 17, 1930, 25107, 17, 4642, 3046, 1922, 2132, 1956, 3]}, "items": [{"id": "p_2791", "content": "Asenapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28826, 2175, 12184, 3, 3]}]}
{"query": {"id": "q_2792", "content": "haloperidol [SEP] Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizop", "tokenized_content": [2, 25107, 3, 4348, 1930, 5407, 1927, 28826, 2175, 12184, 1922, 43, 5936, 17, 1930, 25107, 17, 4642, 3046, 1922, 2132, 1956, 3939, 17021, 1927, 7071, 2011, 3]}, "items": [{"id": "p_2792", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_2793", "content": "schizophrenia [SEP] peridol-controlled trial in patients with acute exacerbation of schizophrenia.", "tokenized_content": [2, 7899, 3, 2953, 22389, 1024, 17, 4642, 3046, 1922, 2132, 1956, 3939, 17021, 1927, 7899, 18, 3]}, "items": [{"id": "p_2793", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_2794", "content": "Asenapine [SEP] Asenapine is approved by the Food and Drugs Administration in adults for ", "tokenized_content": [2, 28826, 2175, 12184, 3, 28826, 2175, 12184, 1977, 4871, 2007, 1920, 3959, 1930, 4195, 4183, 1922, 4440, 1958, 3]}, "items": [{"id": "p_2794", "content": "Asenapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28826, 2175, 12184, 3, 3]}]}
{"query": {"id": "q_2795", "content": "schizophrenia [SEP]  Food and Drugs Administration in adults for acute treatment of schizophrenia or of manic or mixed episodes associated with bipolar I disorde", "tokenized_content": [2, 7899, 3, 3959, 1930, 4195, 4183, 1922, 4440, 1958, 3939, 2311, 1927, 7899, 2014, 1927, 2323, 1935, 2014, 4985, 9232, 2458, 1956, 10275, 51, 2054, 2538, 1021, 3]}, "items": [{"id": "p_2795", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_2796", "content": "manic [SEP] nistration in adults for acute treatment of schizophrenia or of manic or mixed episodes associated with bipolar I disorder with or wi", "tokenized_content": [2, 2323, 1935, 3, 17299, 6003, 1922, 4440, 1958, 3939, 2311, 1927, 7899, 2014, 1927, 2323, 1935, 2014, 4985, 9232, 2458, 1956, 10275, 51, 4770, 1956, 2014, 11980, 3]}, "items": [{"id": "p_2796", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_2797", "content": "bipolar I disorder [SEP]  of schizophrenia or of manic or mixed episodes associated with bipolar I disorder with or without psychotic features. In a double-blind 6-week tr", "tokenized_content": [2, 10275, 51, 4770, 3, 1927, 7899, 2014, 1927, 2323, 1935, 2014, 4985, 9232, 2458, 1956, 10275, 51, 4770, 1956, 2014, 2979, 16651, 4075, 18, 1922, 43, 4825, 17, 7109, 26, 3]}, "items": [{"id": "p_2797", "content": "Bipolar Disorder [SEP] A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and rec", "score": 1, "type": null, "tokenized_content": [2, 10275, 4770, 3, 43, 3044, 11863, 4770, 4961, 2007, 4010, 9494, 24775, 1036, 12, 2323, 1935, 2014, 3044, 7745, 9232, 13, 1930, 43, 10080, 1942, 10221, 1930, 2090, 3]}]}
{"query": {"id": "q_2798", "content": "psychotic [SEP] xed episodes associated with bipolar I disorder with or without psychotic features. In a double-blind 6-week trial, 458 patients with acu", "tokenized_content": [2, 16651, 3, 29767, 1007, 9232, 2458, 1956, 10275, 51, 4770, 1956, 2014, 2979, 16651, 4075, 18, 1922, 43, 4825, 17, 7109, 26, 17, 2982, 3046, 16, 29810, 2132, 1956, 2000, 3]}, "items": [{"id": "p_2798", "content": "Psychotic Disorders [SEP] Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent halluc", "score": 1, "type": null, "tokenized_content": [2, 16651, 4414, 3, 4414, 1922, 2154, 2276, 1977, 43, 3257, 1927, 7282, 1037, 11471, 2014, 43, 10461, 6159, 1922, 15928, 4213, 1956, 2723, 3910, 2014, 8753, 20958, 3]}]}
{"query": {"id": "q_2799", "content": "asenapine [SEP] hizophrenia were randomly assigned to fixed-dose treatment with asenapine at 5 mg twice daily (BID), asenapine at 10 mg BID, placebo, or ", "tokenized_content": [2, 28826, 2175, 12184, 3, 10220, 13642, 2102, 2825, 2126, 1985, 6266, 6304, 1942, 4779, 17, 3253, 2311, 1956, 28826, 2175, 12184, 2019, 25, 2786, 6470, 4692, 12, 12355, 13, 16, 3]}, "items": [{"id": "p_2799", "content": "Asenapine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28826, 2175, 12184, 3, 3]}]}
{"query": {"id": "q_2800", "content": "haloperidol [SEP]  at 5 mg twice daily (BID), asenapine at 10 mg BID, placebo, or haloperidol at 4 mg BID (to verify assay sensitivity). With last observatio", "tokenized_content": [2, 25107, 3, 2019, 25, 2786, 6470, 4692, 12, 12355, 13, 16, 28826, 2175, 12184, 2019, 2119, 2786, 12355, 16, 5936, 16, 2014, 25107, 2019, 24, 2786, 12355, 12, 1942, 10491, 3]}, "items": [{"id": "p_2800", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_2801", "content": "Extrapyramidal symptoms [SEP] 5 and 10 mg BID, haloperidol, and placebo groups, respectively. Extrapyramidal symptoms reported as AEs occurred in 15% and 18%, 34%, and 10% of the as", "tokenized_content": [2, 21346, 3553, 25238, 1923, 3601, 3, 25, 1930, 2119, 2786, 12355, 16, 25107, 16, 1930, 5936, 2671, 16, 2763, 18, 21346, 3553, 25238, 1923, 3601, 2568, 1966, 12893, 4807, 1922, 3]}, "items": [{"id": "p_2801", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_2802", "content": "extrapyramidal symptoms [SEP] and haloperidol; greater contrasts were seen in AEs, especially extrapyramidal symptoms.", "tokenized_content": [2, 21346, 3553, 25238, 1923, 3601, 3, 1930, 25107, 31, 3430, 15364, 1985, 3945, 1922, 12893, 16, 4369, 21346, 3553, 25238, 1923, 3601, 18, 3]}, "items": [{"id": "p_2802", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_2803", "content": "puromycin aminonucleoside [SEP] stribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis.", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 2114, 2023, 2306, 1927, 4008, 2697, 1922, 1920, 11655, 7104, 1922, 3120, 19750, 3835, 1022, 2626, 8028, 7737, 4870, 18, 3]}, "items": [{"id": "p_2803", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_2804", "content": "nephrosis [SEP] ns in the glomerular barrier in early puromycin aminonucleoside nephrosis.", "tokenized_content": [2, 7737, 4870, 3, 4246, 1922, 1920, 11655, 7104, 1922, 3120, 19750, 3835, 1022, 2626, 8028, 7737, 4870, 18, 3]}, "items": [{"id": "p_2804", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_2805", "content": "proteinuria [SEP] D/AIMS: It is still unclear what happens in the glomerulus when proteinuria starts. Using puromycin aminonucleoside nephrosis (PAN) rats, w", "tokenized_content": [2, 15831, 3, 46, 19, 8267, 30, 2176, 1977, 3974, 6390, 4663, 20686, 1922, 1920, 19268, 1957, 2469, 15831, 15447, 18, 2193, 19750, 3835, 1022, 2626, 8028, 7737, 4870, 12, 3797, 3]}, "items": [{"id": "p_2805", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2806", "content": "puromycin aminonucleoside [SEP] r what happens in the glomerulus when proteinuria starts. Using puromycin aminonucleoside nephrosis (PAN) rats, we studied early ultrastructural and perm", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 60, 4663, 20686, 1922, 1920, 19268, 1957, 2469, 15831, 15447, 18, 2193, 19750, 3835, 1022, 2626, 8028, 7737, 4870, 12, 3797, 13, 3615, 16, 3]}, "items": [{"id": "p_2806", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_2807", "content": "nephrosis [SEP] erulus when proteinuria starts. Using puromycin aminonucleoside nephrosis (PAN) rats, we studied early ultrastructural and permeability c", "tokenized_content": [2, 7737, 4870, 3, 25110, 5277, 1036, 2469, 15831, 15447, 18, 2193, 19750, 3835, 1022, 2626, 8028, 7737, 4870, 12, 3797, 13, 3615, 16, 2038, 3942, 3120, 19352, 1930, 8828, 45, 3]}, "items": [{"id": "p_2807", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_2808", "content": "cardiac toxicity [SEP] Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy.", "tokenized_content": [2, 4435, 5532, 3, 13392, 10435, 13250, 1956, 4435, 5532, 2712, 1942, 3004, 9512, 11046, 19, 24019, 12502, 3026, 3181, 18, 3]}, "items": [{"id": "p_2808", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_2809", "content": "lopinavir/ritonavir [SEP] Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy.", "tokenized_content": [2, 3004, 9512, 11046, 19, 24019, 12502, 3026, 3, 13392, 10435, 13250, 1956, 4435, 5532, 2712, 1942, 3004, 9512, 11046, 19, 24019, 12502, 3026, 3181, 18, 3]}, "items": [{"id": "p_2809", "content": "lopinavir-ritonavir drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3004, 9512, 11046, 17, 24019, 12502, 3026, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_2810", "content": "human immunodeficiency virus infection [SEP] were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated ca", "tokenized_content": [2, 2616, 13141, 3413, 2909, 3, 1985, 8813, 28283, 2019, 3323, 3625, 1927, 10879, 1942, 43, 7999, 1956, 2616, 13141, 3413, 2909, 18, 2340, 1927, 1920, 16250, 3530, 4080, 4003, 3367, 3]}, "items": [{"id": "p_2810", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_2811", "content": "heart block [SEP] deficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir thera", "tokenized_content": [2, 4003, 3367, 3, 6179, 3413, 2909, 18, 2340, 1927, 1920, 16250, 3530, 4080, 4003, 3367, 1930, 16434, 14141, 2712, 1942, 3004, 9512, 11046, 19, 24019, 12502, 3026, 2704, 1019, 3]}, "items": [{"id": "p_2811", "content": "Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE", "score": 1, "type": null, "tokenized_content": [2, 4003, 3367, 3, 5761, 12382, 1927, 4435, 21896, 1988, 2112, 4704, 2967, 26264, 4231, 1920, 12382, 3374, 16, 2427, 1966, 2192, 1920, 3132, 6952, 17075, 6267, 3]}]}
{"query": {"id": "q_2812", "content": "dilated cardiomyopathy [SEP]  infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhi", "tokenized_content": [2, 16434, 14141, 3, 2909, 18, 2340, 1927, 1920, 16250, 3530, 4080, 4003, 3367, 1930, 16434, 14141, 2712, 1942, 3004, 9512, 11046, 19, 24019, 12502, 3026, 3181, 16, 43, 26807, 7154, 3]}, "items": [{"id": "p_2812", "content": "Cardiomyopathy, Dilated [SEP] A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk", "score": 1, "type": null, "tokenized_content": [2, 14141, 16, 16434, 3, 43, 2386, 1927, 4435, 3760, 2573, 1988, 1977, 4378, 2007, 6493, 16470, 16, 6493, 5273, 16, 1930, 4003, 4574, 18, 2565, 3]}]}
{"query": {"id": "q_2813", "content": "lopinavir/ritonavir [SEP] oped complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other tw", "tokenized_content": [2, 3004, 9512, 11046, 19, 24019, 12502, 3026, 3, 2494, 1919, 4080, 4003, 3367, 1930, 16434, 14141, 2712, 1942, 3004, 9512, 11046, 19, 24019, 12502, 3026, 3181, 16, 43, 26807, 7154, 3]}, "items": [{"id": "p_2813", "content": "lopinavir-ritonavir drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3004, 9512, 11046, 17, 24019, 12502, 3026, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_2814", "content": "bradycardia [SEP] d protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the ", "tokenized_content": [2, 26192, 3, 46, 7154, 17, 4106, 5899, 16, 2679, 1920, 2303, 13392, 3530, 5809, 26192, 18, 2038, 5732, 12838, 1922, 1920, 2485, 1927, 3004, 9512, 11046, 19, 24019, 12502, 3026, 3]}, "items": [{"id": "p_2814", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_2815", "content": "amnesia [SEP] Learning of rats under amnesia caused by pentobarbital.", "tokenized_content": [2, 14701, 7156, 3, 4809, 1927, 3615, 2441, 14701, 7156, 4189, 2007, 23271, 18, 3]}, "items": [{"id": "p_2815", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_2816", "content": "pentobarbital [SEP] Learning of rats under amnesia caused by pentobarbital.", "tokenized_content": [2, 23271, 3, 4809, 1927, 3615, 2441, 14701, 7156, 4189, 2007, 23271, 18, 3]}, "items": [{"id": "p_2816", "content": "Pentobarbital [SEP] A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given ", "score": 1, "type": null, "tokenized_content": [2, 23271, 3, 43, 3662, 17, 8290, 30434, 4219, 5524, 2057, 1988, 1977, 3655, 1966, 43, 28514, 1930, 25810, 3153, 12, 2308, 2084, 1966, 1925, 2246, 17, 5592, 13, 5899, 1930, 1977, 5394, 3258, 3]}]}
{"query": {"id": "q_2817", "content": "amnesia [SEP] ssociated learning of rats in the normal state and the state of amnesia produced by pentobarbital (15 mg/kg, ip) was carried out. Rats ", "tokenized_content": [2, 14701, 7156, 3, 4577, 2240, 1981, 4809, 1927, 3615, 1922, 1920, 2791, 3360, 1930, 1920, 3360, 1927, 14701, 7156, 4152, 2007, 23271, 12, 2461, 2786, 19, 3621, 16, 5416, 13, 3]}, "items": [{"id": "p_2817", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_2818", "content": "pentobarbital [SEP] f rats in the normal state and the state of amnesia produced by pentobarbital (15 mg/kg, ip) was carried out. Rats were trained to approach a", "tokenized_content": [2, 23271, 3, 48, 3615, 1922, 1920, 2791, 3360, 1930, 1920, 3360, 1927, 14701, 7156, 4152, 2007, 23271, 12, 2461, 2786, 19, 3621, 16, 5416, 13, 1982, 4371, 2397, 18, 3615, 3]}, "items": [{"id": "p_2818", "content": "Pentobarbital [SEP] A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given ", "score": 1, "type": null, "tokenized_content": [2, 23271, 3, 43, 3662, 17, 8290, 30434, 4219, 5524, 2057, 1988, 1977, 3655, 1966, 43, 28514, 1930, 25810, 3153, 12, 2308, 2084, 1966, 1925, 2246, 17, 5592, 13, 5899, 1930, 1977, 5394, 3258, 3]}]}
{"query": {"id": "q_2819", "content": "memory dissociation [SEP] h different shelves in different drug states. It was shown that memory dissociation occurred in both groups. Differences in the parameters of train", "tokenized_content": [2, 4525, 9182, 3, 50, 2413, 18849, 2940, 1922, 2413, 2838, 4376, 18, 2176, 1982, 2522, 1988, 4525, 9182, 4807, 1922, 2321, 2671, 18, 2886, 1922, 1920, 3673, 1927, 12056, 3]}, "items": [{"id": "p_2819", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_2820", "content": "Angiosarcoma [SEP] Angiosarcoma of the liver associated with diethylstilbestrol.", "tokenized_content": [2, 29220, 5735, 15618, 2954, 3, 29220, 5735, 15618, 2954, 1927, 1920, 3568, 2458, 1956, 18622, 2156, 1970, 5873, 2156, 2226, 18, 3]}, "items": [{"id": "p_2820", "content": "Hemangiosarcoma [SEP] A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood ", "score": 1, "type": null, "tokenized_content": [2, 23573, 13063, 3, 43, 5844, 6558, 12132, 4378, 2007, 6221, 13754, 16, 9172, 15089, 16, 25213, 2094, 3595, 2037, 2877, 3]}]}
{"query": {"id": "q_2821", "content": "Angiosarcoma of the liver [SEP] Angiosarcoma of the liver associated with diethylstilbestrol.", "tokenized_content": [2, 29220, 5735, 15618, 2954, 1927, 1920, 3568, 3, 29220, 5735, 15618, 2954, 1927, 1920, 3568, 2458, 1956, 18622, 2156, 1970, 5873, 2156, 2226, 18, 3]}, "items": [{"id": "p_2821", "content": "Liver Neoplasms [SEP] Tumors or cancer of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2822", "content": "diethylstilbestrol [SEP] Angiosarcoma of the liver associated with diethylstilbestrol.", "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 29220, 5735, 15618, 2954, 1927, 1920, 3568, 2458, 1956, 18622, 2156, 1970, 5873, 2156, 2226, 18, 3]}, "items": [{"id": "p_2822", "content": "Diethylstilbestrol [SEP] A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as", "score": 1, "type": null, "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 43, 6830, 29413, 7940, 2251, 1922, 1920, 2311, 1927, 17779, 1930, 14285, 4414, 18, 2176, 1982, 2222, 2251, 22397, 1966, 3]}]}
{"query": {"id": "q_2823", "content": "Angiosarcoma [SEP] Angiosarcoma of the liver occurred in a 76-year-old man who had been treated", "tokenized_content": [2, 29220, 5735, 15618, 2954, 3, 29220, 5735, 15618, 2954, 1927, 1920, 3568, 4807, 1922, 43, 5439, 17, 2476, 17, 4156, 2323, 2746, 2430, 2252, 2868, 3]}, "items": [{"id": "p_2823", "content": "Hemangiosarcoma [SEP] A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood ", "score": 1, "type": null, "tokenized_content": [2, 23573, 13063, 3, 43, 5844, 6558, 12132, 4378, 2007, 6221, 13754, 16, 9172, 15089, 16, 25213, 2094, 3595, 2037, 2877, 3]}]}
{"query": {"id": "q_2824", "content": "Angiosarcoma of the liver [SEP] Angiosarcoma of the liver occurred in a 76-year-old man who had been treated for a well-d", "tokenized_content": [2, 29220, 5735, 15618, 2954, 1927, 1920, 3568, 3, 29220, 5735, 15618, 2954, 1927, 1920, 3568, 4807, 1922, 43, 5439, 17, 2476, 17, 4156, 2323, 2746, 2430, 2252, 2868, 1958, 43, 3]}, "items": [{"id": "p_2824", "content": "Liver Neoplasms [SEP] Tumors or cancer of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2825", "content": "adenocarcinoma [SEP]  76-year-old man who had been treated for a well-differentiated adenocarcinoma of the liver with diethylstilbestrol for 13 years. Angiosarcoma", "tokenized_content": [2, 9573, 3, 5439, 17, 2476, 17, 4156, 2323, 2746, 2430, 2252, 2868, 1958, 43, 2486, 17, 7512, 9573, 1927, 1920, 3568, 1956, 18622, 2156, 1970, 5873, 2156, 2226, 1958, 2590, 3]}, "items": [{"id": "p_2825", "content": "Adenocarcinoma [SEP] A malignant epithelial tumor with a glandular organization.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9573, 3, 43, 6558, 4944, 2798, 1956, 43, 21808, 5901, 18, 3]}]}
{"query": {"id": "q_2826", "content": "adenocarcinoma of the liver [SEP]  76-year-old man who had been treated for a well-differentiated adenocarcinoma of the liver with diethylstilbestrol for 13 years. Angiosarcoma was also pre", "tokenized_content": [2, 9573, 1927, 1920, 3568, 3, 5439, 17, 2476, 17, 4156, 2323, 2746, 2430, 2252, 2868, 1958, 43, 2486, 17, 7512, 9573, 1927, 1920, 3568, 1956, 18622, 2156, 1970, 5873, 2156, 3]}, "items": [{"id": "p_2826", "content": "Liver Neoplasms [SEP] Tumors or cancer of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 15347, 3, 3861, 2014, 2539, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2827", "content": "diethylstilbestrol [SEP] ated for a well-differentiated adenocarcinoma of the liver with diethylstilbestrol for 13 years. Angiosarcoma was also present within pulmonary an", "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 30280, 1007, 1958, 43, 2486, 17, 7512, 9573, 1927, 1920, 3568, 1956, 18622, 2156, 1970, 5873, 2156, 2226, 1958, 2590, 2739, 18, 29220, 3]}, "items": [{"id": "p_2827", "content": "Diethylstilbestrol [SEP] A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as", "score": 1, "type": null, "tokenized_content": [2, 18622, 2156, 1970, 5873, 2156, 2226, 3, 43, 6830, 29413, 7940, 2251, 1922, 1920, 2311, 1927, 17779, 1930, 14285, 4414, 18, 2176, 1982, 2222, 2251, 22397, 1966, 3]}]}
{"query": {"id": "q_2828", "content": "intraarterial lesions [SEP] t within pulmonary and renal arteries. The possibility that the intraarterial lesions might represent independent primary tumors is considered.", "tokenized_content": [2, 5153, 22666, 2086, 4518, 3, 62, 2651, 5352, 1930, 4604, 9345, 18, 1920, 5341, 1988, 1920, 5153, 22666, 2086, 4518, 3284, 3015, 3484, 3065, 3861, 1977, 3311, 18, 3]}, "items": [{"id": "p_2828", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_2829", "content": "tumors [SEP] t the intraarterial lesions might represent independent primary tumors is considered.", "tokenized_content": [2, 3861, 3, 62, 1920, 5153, 22666, 2086, 4518, 3284, 3015, 3484, 3065, 3861, 1977, 3311, 18, 3]}, "items": [{"id": "p_2829", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_2830", "content": "xanthine [SEP] Role of xanthine oxidase in dexamethasone-induced hypertension in rats.", "tokenized_content": [2, 26059, 3, 2770, 1927, 26059, 10488, 1922, 12681, 17, 2719, 5579, 1922, 3615, 18, 3]}, "items": [{"id": "p_2830", "content": "Xanthine [SEP] A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degr", "score": 1, "type": null, "tokenized_content": [2, 26059, 3, 43, 19700, 5170, 2435, 1922, 2501, 3362, 3878, 1930, 13315, 16, 4908, 4793, 16, 1930, 2673, 7075, 2799, 13004, 18, 2176, 1977, 1925, 6129, 1922, 1920, 3744, 1005, 3]}]}
{"query": {"id": "q_2831", "content": "dexamethasone [SEP] Role of xanthine oxidase in dexamethasone-induced hypertension in rats.", "tokenized_content": [2, 12681, 3, 2770, 1927, 26059, 10488, 1922, 12681, 17, 2719, 5579, 1922, 3615, 18, 3]}, "items": [{"id": "p_2831", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_2832", "content": "hypertension [SEP] Role of xanthine oxidase in dexamethasone-induced hypertension in rats.", "tokenized_content": [2, 5579, 3, 2770, 1927, 26059, 10488, 1922, 12681, 17, 2719, 5579, 1922, 3615, 18, 3]}, "items": [{"id": "p_2832", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2833", "content": "hypertension [SEP] 1. Glucocorticoid-induced hypertension (GC-HT) in the rat is associated with nitric oxide-redox imbala", "tokenized_content": [2, 5579, 3, 21, 18, 14469, 17, 2719, 5579, 12, 5469, 17, 5334, 13, 1922, 1920, 3067, 1977, 2458, 1956, 10233, 7491, 17, 9366, 12288, 1019, 3]}, "items": [{"id": "p_2833", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2834", "content": "HT [SEP] 1. Glucocorticoid-induced hypertension (GC-HT) in the rat is associated with nitric oxide-redox imbalance. 2.", "tokenized_content": [2, 5334, 3, 21, 18, 14469, 17, 2719, 5579, 12, 5469, 17, 5334, 13, 1922, 1920, 3067, 1977, 2458, 1956, 10233, 7491, 17, 9366, 14093, 18, 22, 18, 3]}, "items": [{"id": "p_2834", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2835", "content": "nitric oxide [SEP] coid-induced hypertension (GC-HT) in the rat is associated with nitric oxide-redox imbalance. 2. We studied the role of xanthine oxidase (XO", "tokenized_content": [2, 10233, 7491, 3, 24073, 1007, 17, 2719, 5579, 12, 5469, 17, 5334, 13, 1922, 1920, 3067, 1977, 2458, 1956, 10233, 7491, 17, 9366, 14093, 18, 22, 18, 2038, 3942, 1920, 3]}, "items": [{"id": "p_2835", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_2836", "content": "xanthine [SEP] ed with nitric oxide-redox imbalance. 2. We studied the role of xanthine oxidase (XO), which is implicated in the production of reactive", "tokenized_content": [2, 26059, 3, 3347, 1956, 10233, 7491, 17, 9366, 14093, 18, 22, 18, 2038, 3942, 1920, 2770, 1927, 26059, 10488, 12, 66, 1037, 13, 16, 2154, 1977, 6835, 1922, 1920, 3372, 3]}, "items": [{"id": "p_2836", "content": "Xanthine [SEP] A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degr", "score": 1, "type": null, "tokenized_content": [2, 26059, 3, 43, 19700, 5170, 2435, 1922, 2501, 3362, 3878, 1930, 13315, 16, 4908, 4793, 16, 1930, 2673, 7075, 2799, 13004, 18, 2176, 1977, 1925, 6129, 1922, 1920, 3744, 1005, 3]}]}
{"query": {"id": "q_2837", "content": "dexamethasone [SEP]  is implicated in the production of reactive oxygen species, in dexamethasone-induced hypertension (dex-HT). 3. Thirty male Sprague-Dawley ra", "tokenized_content": [2, 12681, 3, 1977, 6835, 1922, 1920, 3372, 1927, 6079, 4612, 3038, 16, 1922, 12681, 17, 2719, 5579, 12, 7473, 17, 5334, 13, 18, 23, 18, 9942, 4005, 15684, 17, 15798, 3]}, "items": [{"id": "p_2837", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_2838", "content": "dex [SEP]  is implicated in the production of reactive oxygen species, in dexamethasone-induced hypertension (dex-HT). 3. Thirty male Sprague", "tokenized_content": [2, 7473, 3, 1977, 6835, 1922, 1920, 3372, 1927, 6079, 4612, 3038, 16, 1922, 12681, 17, 2719, 5579, 12, 7473, 17, 5334, 13, 18, 23, 18, 9942, 4005, 15684, 3]}, "items": [{"id": "p_2838", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_2839", "content": "allopurinol [SEP] ndomly into four treatment groups: saline, dexamethasone (dex), allopurinol plus saline, and allopurinol plus dex. 4. Systolic blood pressu", "tokenized_content": [2, 24551, 13076, 1945, 3, 8026, 1947, 1954, 2460, 3006, 2311, 2671, 30, 5977, 16, 12681, 12, 7473, 13, 16, 24551, 13076, 1945, 5390, 5977, 16, 1930, 24551, 13076, 1945, 5390, 3]}, "items": [{"id": "p_2839", "content": "Allopurinol [SEP] A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.\n ", "score": 1, "type": null, "tokenized_content": [2, 24551, 13076, 1945, 3, 43, 26059, 10488, 4106, 1988, 6386, 17607, 2687, 3372, 18, 2176, 2222, 8016, 1966, 1925, 20330, 9215, 4627, 12191, 2057, 1990, 2673, 20552, 7373, 18, 3]}]}
{"query": {"id": "q_2840", "content": "urate [SEP] ight was used as a marker of glucocorticoid activity, and serum urate to assess XO inhibition. 5. Dex increased SBP (110 +/- 2-126 +/", "tokenized_content": [2, 3674, 2010, 3, 20733, 1031, 1982, 2251, 1966, 43, 4966, 1927, 14469, 2455, 16, 1930, 3256, 3674, 2010, 1942, 2634, 66, 1037, 3523, 18, 25, 18, 7473, 2502, 12345, 12, 3]}, "items": [{"id": "p_2840", "content": "Uric Acid [SEP] An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product o", "score": 1, "type": null, "tokenized_content": [2, 17607, 2687, 3, 1925, 6638, 4863, 16, 3454, 26059, 10488, 16, 1927, 20004, 1034, 17687, 1036, 2427, 1966, 26059, 1930, 5918, 24943, 18, 2176, 1977, 1920, 3948, 6638, 4863, 57, 3]}]}
{"query": {"id": "q_2841", "content": "Dex [SEP] corticoid activity, and serum urate to assess XO inhibition. 5. Dex increased SBP (110 +/- 2-126 +/- 3 mmHg; P < 0.001) and decreas", "tokenized_content": [2, 7473, 3, 8106, 2642, 2455, 16, 1930, 3256, 3674, 2010, 1942, 2634, 66, 1037, 3523, 18, 25, 18, 7473, 2502, 12345, 12, 8139, 15, 19, 17, 22, 17, 10483, 15, 3]}, "items": [{"id": "p_2841", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_2842", "content": "increased SBP [SEP] icoid activity, and serum urate to assess XO inhibition. 5. Dex increased SBP (110 +/- 2-126 +/- 3 mmHg; P < 0.001) and decreased thymus (P <", "tokenized_content": [2, 2502, 12345, 3, 3996, 2642, 2455, 16, 1930, 3256, 3674, 2010, 1942, 2634, 66, 1037, 3523, 18, 25, 18, 7473, 2502, 12345, 12, 8139, 15, 19, 17, 22, 17, 10483, 3]}, "items": [{"id": "p_2842", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2843", "content": "decreased thymus (P < 0.001) and bodyweights [SEP]  5. Dex increased SBP (110 +/- 2-126 +/- 3 mmHg; P < 0.001) and decreased thymus (P < 0.001) and bodyweights (P\" < 0.01). Allopurinol decreased serum urate from 76 +/- 5 to", "tokenized_content": [2, 3261, 15004, 12, 58, 32, 20, 18, 3472, 13, 1930, 3362, 7987, 1036, 3, 25, 18, 7473, 2502, 12345, 12, 8139, 15, 19, 17, 22, 17, 10483, 15, 19, 17, 3]}, "items": [{"id": "p_2843", "content": "Weight Loss [SEP] Decrease in existing BODY WEIGHT.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3388, 3257, 3, 3714, 1922, 6124, 3362, 3388, 18, 3]}]}
{"query": {"id": "q_2844", "content": "Allopurinol [SEP] ) and decreased thymus (P < 0.001) and bodyweights (P\" < 0.01). Allopurinol decreased serum urate from 76 +/- 5 to 30 +/- 3 micromol/L (P <", "tokenized_content": [2, 24551, 13076, 1945, 3, 13, 1930, 3261, 15004, 12, 58, 32, 20, 18, 3472, 13, 1930, 3362, 7987, 1036, 12, 58, 6, 32, 20, 18, 3287, 13, 18, 24551, 13076, 3]}, "items": [{"id": "p_2844", "content": "Allopurinol [SEP] A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.\n ", "score": 1, "type": null, "tokenized_content": [2, 24551, 13076, 1945, 3, 43, 26059, 10488, 4106, 1988, 6386, 17607, 2687, 3372, 18, 2176, 2222, 8016, 1966, 1925, 20330, 9215, 4627, 12191, 2057, 1990, 2673, 20552, 7373, 18, 3]}]}
{"query": {"id": "q_2845", "content": "risperidone [SEP] Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels.", "tokenized_content": [2, 26991, 3, 21346, 3553, 25238, 1923, 4159, 2564, 1956, 26991, 1930, 25107, 2019, 5596, 8631, 3148, 13771, 2428, 18, 3]}, "items": [{"id": "p_2845", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_2846", "content": "haloperidol [SEP] Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels.", "tokenized_content": [2, 25107, 3, 21346, 3553, 25238, 1923, 4159, 2564, 1956, 26991, 1930, 25107, 2019, 5596, 8631, 3148, 13771, 2428, 18, 3]}, "items": [{"id": "p_2846", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_2847", "content": "Risperidone [SEP] Risperidone is an antipsychotic drug with high affinity at dopamine D2 and ", "tokenized_content": [2, 26991, 3, 26991, 1977, 1925, 17581, 2838, 1956, 2149, 5173, 2019, 7964, 8631, 1930, 3]}, "items": [{"id": "p_2847", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_2848", "content": "dopamine [SEP] Risperidone is an antipsychotic drug with high affinity at dopamine D2 and serotonin 5-HT2 receptors. Previous clinical studies hav", "tokenized_content": [2, 7964, 3, 26991, 1977, 1925, 17581, 2838, 1956, 2149, 5173, 2019, 7964, 8631, 1930, 11153, 25, 17, 5334, 1028, 4086, 18, 2555, 2535, 2351, 25838, 3]}, "items": [{"id": "p_2848", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2849", "content": "serotonin 5-HT2 [SEP]  is an antipsychotic drug with high affinity at dopamine D2 and serotonin 5-HT2 receptors. Previous clinical studies have proposed that risperi", "tokenized_content": [2, 11153, 25, 17, 5334, 1028, 3, 1977, 1925, 17581, 2838, 1956, 2149, 5173, 2019, 7964, 8631, 1930, 11153, 25, 17, 5334, 1028, 4086, 18, 2555, 2535, 2351, 2162, 4211, 1988, 3]}, "items": [{"id": "p_2849", "content": "Receptors, Serotonin, 5-HT2 [SEP] A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to the GQ-G11 G-PROTEINS resulting in increased i", "score": 1, "type": null, "tokenized_content": [2, 4086, 16, 11153, 16, 25, 17, 5334, 1028, 3, 43, 17625, 1927, 49, 17, 2213, 6416, 11153, 4086, 1988, 15116, 10662, 1942, 1920, 21194, 17, 8533, 1009, 49, 17, 2697, 3864, 1922, 2502, 51, 3]}]}
{"query": {"id": "q_2850", "content": "risperidone [SEP] n 5-HT2 receptors. Previous clinical studies have proposed that risperidone's pharmacologic profile may produce improved efficacy for negat", "tokenized_content": [2, 26991, 3, 56, 25, 17, 5334, 1028, 4086, 18, 2555, 2535, 2351, 2162, 4211, 1988, 26991, 11, 61, 17225, 5174, 2278, 5074, 4305, 4348, 1958, 2922, 1926, 3]}, "items": [{"id": "p_2850", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_2851", "content": "psychotic symptoms [SEP] harmacologic profile may produce improved efficacy for negative psychotic symptoms and decreased propensity for extrapyramidal side effects; featu", "tokenized_content": [2, 16651, 3601, 3, 7613, 20682, 22284, 1935, 5174, 2278, 5074, 4305, 4348, 1958, 3136, 16651, 3601, 1930, 3261, 12020, 1958, 21346, 3553, 25238, 1923, 4159, 2564, 31, 19341, 1032, 3]}, "items": [{"id": "p_2851", "content": "Psychotic Disorders [SEP] Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent halluc", "score": 1, "type": null, "tokenized_content": [2, 16651, 4414, 3, 4414, 1922, 2154, 2276, 1977, 43, 3257, 1927, 7282, 1037, 11471, 2014, 43, 10461, 6159, 1922, 15928, 4213, 1956, 2723, 3910, 2014, 8753, 20958, 3]}]}
{"query": {"id": "q_2852", "content": "haloperidol [SEP]  treated with routine clinical doses of risperidone (n = 12) or haloperidol (n = 7). Both risperidone and haloperidol produced D2 occupancy", "tokenized_content": [2, 25107, 3, 2868, 1956, 7341, 2535, 5312, 1927, 26991, 12, 56, 33, 2369, 13, 2014, 25107, 12, 56, 33, 27, 13, 18, 2321, 26991, 1930, 25107, 4152, 8631, 13771, 3]}, "items": [{"id": "p_2852", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_2853", "content": "Drug-induced parkinsonism [SEP] ween occupancy levels obtained with haloperidol or risperidone. Drug-induced parkinsonism was observed in subjects treated with risperidone (42%) and hal", "tokenized_content": [2, 2838, 17, 2719, 26214, 3, 2038, 1917, 13771, 2428, 2926, 1956, 25107, 2014, 26991, 18, 2838, 17, 2719, 26214, 1982, 2528, 1922, 3297, 2868, 1956, 26991, 12, 3858, 9, 13, 3]}, "items": [{"id": "p_2853", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_2854", "content": "Simvastatin-ezetimibe [SEP] Simvastatin-ezetimibe-induced hepatic failure necessitating liver transplantation.", "tokenized_content": [2, 21555, 17, 11650, 4988, 7395, 5873, 3, 21555, 17, 11650, 4988, 7395, 5873, 17, 2719, 6095, 4574, 16593, 2287, 3568, 6530, 18, 3]}, "items": [{"id": "p_2854", "content": "ezetimibe, simvastatin drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11650, 4988, 7395, 5873, 16, 21555, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_2855", "content": "hepatic failure [SEP] Simvastatin-ezetimibe-induced hepatic failure necessitating liver transplantation.", "tokenized_content": [2, 6095, 4574, 3, 21555, 17, 11650, 4988, 7395, 5873, 17, 2719, 6095, 4574, 16593, 2287, 3568, 6530, 18, 3]}, "items": [{"id": "p_2855", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_2856", "content": "statin [SEP] t of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) therapy. However, hepatotoxic events have not been widely publ", "tokenized_content": [2, 10838, 3, 62, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 4106, 12, 10838, 13, 3181, 18, 2406, 16, 5746, 12899, 3916, 2162, 2084, 2252, 3]}, "items": [{"id": "p_2856", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_2857", "content": "hepatotoxic [SEP] taryl coenzyme A reductase inhibitor (statin) therapy. However, hepatotoxic events have not been widely published with ezetimibe or the com", "tokenized_content": [2, 5746, 12899, 3, 14517, 2199, 22051, 43, 11386, 4106, 12, 10838, 13, 3181, 18, 2406, 16, 5746, 12899, 3916, 2162, 2084, 2252, 5673, 4586, 1956, 11650, 4988, 7395, 5873, 2014, 3]}, "items": [{"id": "p_2857", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2858", "content": "ezetimibe [SEP] However, hepatotoxic events have not been widely published with ezetimibe or the combination agent simvastatin-ezetimibe. We describe a 7", "tokenized_content": [2, 11650, 4988, 7395, 5873, 3, 2406, 16, 5746, 12899, 3916, 2162, 2084, 2252, 5673, 4586, 1956, 11650, 4988, 7395, 5873, 2014, 1920, 3921, 5899, 21555, 17, 11650, 4988, 7395, 5873, 3]}, "items": [{"id": "p_2858", "content": "ezetimibe [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11650, 4988, 7395, 5873, 3, 3]}]}
{"query": {"id": "q_2859", "content": "simvastatin-ezetimibe [SEP] t been widely published with ezetimibe or the combination agent simvastatin-ezetimibe. We describe a 70-year-old Hispanic woman who developed fulmina", "tokenized_content": [2, 21555, 17, 11650, 4988, 7395, 5873, 3, 62, 2252, 5673, 4586, 1956, 11650, 4988, 7395, 5873, 2014, 1920, 3921, 5899, 21555, 17, 11650, 4988, 7395, 5873, 18, 2038, 5993, 43, 3]}, "items": [{"id": "p_2859", "content": "ezetimibe, simvastatin drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11650, 4988, 7395, 5873, 16, 21555, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_2860", "content": "fulminant hepatic failure [SEP] etimibe. We describe a 70-year-old Hispanic woman who developed fulminant hepatic failure necessitating liver transplantation 10 weeks after conversion f", "tokenized_content": [2, 5257, 8547, 2031, 6095, 4574, 3, 8096, 7395, 5873, 18, 2038, 5993, 43, 3895, 17, 2476, 17, 4156, 10542, 10440, 2746, 3530, 5257, 8547, 2031, 6095, 4574, 16593, 2287, 3568, 3]}, "items": [{"id": "p_2860", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_2861", "content": "simvastatin [SEP] t been widely published with ezetimibe or the combination agent simvastatin-ezetimibe. We describe a 70-year-old Hispanic woman who develop", "tokenized_content": [2, 21555, 3, 62, 2252, 5673, 4586, 1956, 11650, 4988, 7395, 5873, 2014, 1920, 3921, 5899, 21555, 17, 11650, 4988, 7395, 5873, 18, 2038, 5993, 43, 3895, 17, 2476, 17, 4156, 3]}, "items": [{"id": "p_2861", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_2862", "content": "simvastatin 10 mg-ezetimibe 40 mg [SEP] ntation 10 weeks after conversion from simvastatin 40 mg/day to simvastatin 10 mg-ezetimibe 40 mg/day. The patient's lipid panel had been maintained with simvast", "tokenized_content": [2, 21555, 2119, 2786, 17, 11650, 4988, 7395, 5873, 3040, 2786, 3, 20503, 1929, 2119, 3625, 2256, 7309, 2037, 21555, 3040, 2786, 19, 3007, 1942, 21555, 2119, 2786, 17, 11650, 4988, 3]}, "items": [{"id": "p_2862", "content": "ezetimibe, simvastatin drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11650, 4988, 7395, 5873, 16, 21555, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_2863", "content": "hepatotoxicity [SEP] astatin for 18 months before the conversion without evidence of hepatotoxicity. A routine laboratory work-up 10 weeks after conversion reveale", "tokenized_content": [2, 24126, 3, 5988, 3248, 1958, 2654, 3221, 3119, 1920, 7309, 2979, 3095, 1927, 24126, 18, 43, 7341, 4542, 2778, 17, 2353, 2119, 3625, 2256, 7309, 3157, 1021, 3]}, "items": [{"id": "p_2863", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2864", "content": "Simvastatinezetimibe [SEP] ter conversion revealed elevated serum aminotransferase levels. Simvastatinezetimibe and escitalopram (which she was taking for depression) were dis", "tokenized_content": [2, 21555, 11788, 4988, 7395, 5873, 3, 6005, 7309, 3404, 4664, 3256, 15817, 2428, 18, 21555, 11788, 4988, 7395, 5873, 1930, 14382, 27229, 12, 2154, 4693, 1982, 6303, 1958, 4621, 13, 3]}, "items": [{"id": "p_2864", "content": "ezetimibe, simvastatin drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11650, 4988, 7395, 5873, 16, 21555, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_2865", "content": "escitalopram [SEP] levated serum aminotransferase levels. Simvastatinezetimibe and escitalopram (which she was taking for depression) were discontinued, and ot", "tokenized_content": [2, 14382, 27229, 3, 10157, 1981, 3256, 15817, 2428, 18, 21555, 11788, 4988, 7395, 5873, 1930, 14382, 27229, 12, 2154, 4693, 1982, 6303, 1958, 4621, 13, 1985, 16087, 16, 1930, 7608, 3]}, "items": [{"id": "p_2865", "content": "Citalopram [SEP] A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in redu", "score": 1, "type": null, "tokenized_content": [2, 12366, 20807, 13399, 1035, 3, 43, 28028, 15895, 6299, 12407, 1988, 1977, 2340, 1927, 1920, 11153, 5047, 4472, 2251, 1966, 1925, 14183, 18, 1920, 2838, 1977, 2222, 3655, 1922, 2312, 1032, 3]}]}
{"query": {"id": "q_2866", "content": "depression [SEP] Simvastatinezetimibe and escitalopram (which she was taking for depression) were discontinued, and other potential causes of hepatotoxicit", "tokenized_content": [2, 4621, 3, 21555, 11788, 4988, 7395, 5873, 1930, 14382, 27229, 12, 2154, 4693, 1982, 6303, 1958, 4621, 13, 1985, 16087, 16, 1930, 2303, 2889, 5092, 1927, 5746, 12899, 1932, 3]}, "items": [{"id": "p_2866", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_2867", "content": "drug toxicity [SEP] evels, and liver biopsy revealed evidence of moderate-to-severe drug toxicity. She underwent liver transplantation with an uneventful postope", "tokenized_content": [2, 2838, 5532, 3, 2180, 3222, 16, 1930, 3568, 6831, 3404, 3095, 1927, 5086, 17, 1942, 17, 4010, 2838, 5532, 18, 4693, 5468, 3568, 6530, 1956, 1925, 29641, 2753, 4907, 3]}, "items": [{"id": "p_2867", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2868", "content": "Ezetimibe [SEP] tive day 23, and her 2-year follow-up showed no adverse events. Ezetimibe undergoes extensive glucuronidation by uridine diphosphate gluc", "tokenized_content": [2, 11650, 4988, 7395, 5873, 3, 8685, 1961, 3007, 3020, 16, 1930, 3656, 22, 17, 2476, 2396, 17, 2353, 2594, 2239, 5246, 3916, 18, 11650, 4988, 7395, 5873, 14928, 6475, 17102, 3]}, "items": [{"id": "p_2868", "content": "ezetimibe [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11650, 4988, 7395, 5873, 3, 3]}]}
{"query": {"id": "q_2869", "content": "uridine diphosphate [SEP] dverse events. Ezetimibe undergoes extensive glucuronidation by uridine diphosphate glucoronosyltransferases (UGT) in the intestine and liver and m", "tokenized_content": [2, 26104, 23266, 3, 11203, 2045, 1021, 3916, 18, 11650, 4988, 7395, 5873, 14928, 6475, 17102, 20356, 2007, 26104, 23266, 3351, 30515, 25566, 1036, 12, 18684, 13, 1922, 1920, 9887, 1930, 3]}, "items": [{"id": "p_2869", "content": "Uridine Diphosphate [SEP] A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26104, 23266, 3, 43, 22761, 5489, 3165, 43, 24937, 2210, 9603, 2828, 1942, 13441, 1927, 1920, 9523, 11804, 18, 3]}]}
{"query": {"id": "q_2870", "content": "simvastatin hydroxy acid [SEP] testine and liver and may have inhibited the glucuronidation of simvastatin hydroxy acid, resulting in increased simvastatin exposure and subsequent hep", "tokenized_content": [2, 21555, 8275, 2687, 3, 2648, 2053, 1930, 3568, 1930, 2278, 2162, 5069, 1920, 17102, 20356, 1927, 21555, 8275, 2687, 16, 3864, 1922, 2502, 21555, 3395, 1930, 4521, 3357, 3]}, "items": [{"id": "p_2870", "content": "simvastatin hydroxyacid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21555, 8275, 29272, 3, 3]}]}
{"query": {"id": "q_2871", "content": "liver failure [SEP]  this is the first case report of simvastatin-ezetimibe-induced liver failure that resulted in liver transplantation. We postulate that the m", "tokenized_content": [2, 3568, 4574, 3, 2052, 1977, 1920, 2561, 3087, 3809, 1927, 21555, 17, 11650, 4988, 7395, 5873, 17, 2719, 3568, 4574, 1988, 4306, 1922, 3568, 6530, 18, 2038, 23911, 1988, 1920, 3]}, "items": [{"id": "p_2871", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_2872", "content": "simvastatinezetimibe [SEP] n liver transplantation. We postulate that the mechanism of the simvastatinezetimibe-induced hepatotoxicity is the increased simvastatin exposure by", "tokenized_content": [2, 21555, 11788, 4988, 7395, 5873, 3, 56, 3568, 6530, 18, 2038, 23911, 1988, 1920, 2856, 1927, 1920, 21555, 11788, 4988, 7395, 5873, 17, 2719, 24126, 1977, 1920, 2502, 21555, 3395, 3]}, "items": [{"id": "p_2872", "content": "ezetimibe, simvastatin drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11650, 4988, 7395, 5873, 16, 21555, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_2873", "content": "Methamphetamine [SEP] dical risks associated with this serious condition. BACKGROUND: Methamphetamine is a very addictive, powerful stimulant that increases wakefuln", "tokenized_content": [2, 20375, 3, 9192, 1923, 7481, 2458, 1956, 2052, 7433, 2625, 18, 3872, 30, 20375, 1977, 43, 3345, 24765, 16, 9974, 24252, 1988, 4041, 14763, 2903, 1022, 3]}, "items": [{"id": "p_2873", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_2874", "content": "cardiac dysrhythmias [SEP] ess and physical activity and can produce other effects such as cardiac dysrhythmias, hypertension, hallucinations, and violent behavior. Dental pat", "tokenized_content": [2, 4435, 3890, 5004, 4626, 15519, 3, 4023, 1930, 3841, 2455, 1930, 2112, 5074, 2303, 2564, 2427, 1966, 4435, 3890, 5004, 4626, 15519, 16, 5579, 16, 27013, 16, 1930, 20576, 3379, 3]}, "items": [{"id": "p_2874", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_2875", "content": "hypertension [SEP] ity and can produce other effects such as cardiac dysrhythmias, hypertension, hallucinations, and violent behavior. Dental patients abusing ", "tokenized_content": [2, 5579, 3, 2176, 1012, 1930, 2112, 5074, 2303, 2564, 2427, 1966, 4435, 3890, 5004, 4626, 15519, 16, 5579, 16, 27013, 16, 1930, 20576, 3379, 18, 7915, 2132, 2186, 16435, 3]}, "items": [{"id": "p_2875", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2876", "content": "hallucinations [SEP] oduce other effects such as cardiac dysrhythmias, hypertension, hallucinations, and violent behavior. Dental patients abusing methamphetamine ", "tokenized_content": [2, 27013, 3, 4426, 3005, 2303, 2564, 2427, 1966, 4435, 3890, 5004, 4626, 15519, 16, 5579, 16, 27013, 16, 1930, 20576, 3379, 18, 7915, 2132, 2186, 16435, 20375, 3]}, "items": [{"id": "p_2876", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_2877", "content": "violent behavior [SEP] such as cardiac dysrhythmias, hypertension, hallucinations, and violent behavior. Dental patients abusing methamphetamine can present with poor ", "tokenized_content": [2, 20576, 3379, 3, 2427, 1966, 4435, 3890, 5004, 4626, 15519, 16, 5579, 16, 27013, 16, 1930, 20576, 3379, 18, 7915, 2132, 2186, 16435, 20375, 2112, 2481, 1956, 3930, 3]}, "items": [{"id": "p_2877", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_2878", "content": "methamphetamine [SEP] , hallucinations, and violent behavior. Dental patients abusing methamphetamine can present with poor oral hygiene, xerostomia, rampant caries ", "tokenized_content": [2, 20375, 3, 16, 27013, 16, 1930, 20576, 3379, 18, 7915, 2132, 2186, 16435, 20375, 2112, 2481, 1956, 3930, 4726, 15205, 16, 27833, 28009, 2126, 16, 18682, 2031, 14989, 3]}, "items": [{"id": "p_2878", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_2879", "content": "xerostomia [SEP] nts abusing methamphetamine can present with poor oral hygiene, xerostomia, rampant caries (\"meth mouth\"), and excessive tooth wear. Oral ", "tokenized_content": [2, 27833, 28009, 2126, 3, 17969, 2186, 16435, 20375, 2112, 2481, 1956, 3930, 4726, 15205, 16, 27833, 28009, 2126, 16, 18682, 2031, 14989, 12, 6, 2295, 11701, 6, 13, 16, 1930, 3]}, "items": [{"id": "p_2879", "content": "Xerostomia [SEP] Decreased salivary flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27833, 28009, 2126, 3, 3261, 11866, 3426, 18, 3]}]}
{"query": {"id": "q_2880", "content": "caries [SEP] etamine can present with poor oral hygiene, xerostomia, rampant caries (\"meth mouth\"), and excessive tooth wear. Oral rehabilitation o", "tokenized_content": [2, 14989, 3, 20634, 25157, 2112, 2481, 1956, 3930, 4726, 15205, 16, 27833, 28009, 2126, 16, 18682, 2031, 14989, 12, 6, 2295, 11701, 6, 13, 16, 1930, 9122, 10007, 12615, 18, 3]}, "items": [{"id": "p_2880", "content": "Dental Caries [SEP] Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic str", "score": 1, "type": null, "tokenized_content": [2, 7915, 14989, 3, 6579, 12102, 1927, 1920, 10007, 3154, 7796, 2007, 2344, 8515, 3123, 1927, 1920, 16145, 3489, 2007, 8145, 8502, 1927, 6805, 2114, 3]}]}
{"query": {"id": "q_2881", "content": "tooth wear [SEP] giene, xerostomia, rampant caries (\"meth mouth\"), and excessive tooth wear. Oral rehabilitation of patients using methamphetamine can be c", "tokenized_content": [2, 10007, 12615, 3, 7217, 2880, 16, 27833, 28009, 2126, 16, 18682, 2031, 14989, 12, 6, 2295, 11701, 6, 13, 16, 1930, 9122, 10007, 12615, 18, 4726, 9301, 1927, 2132, 2193, 3]}, "items": [{"id": "p_2881", "content": "Tooth Wear [SEP] Loss of the tooth substance by chemical or mechanical processes\n    ", "score": 1, "type": null, "tokenized_content": [2, 10007, 12615, 3, 3257, 1927, 1920, 10007, 7311, 2007, 4399, 2014, 5821, 4028, 3]}]}
{"query": {"id": "q_2882", "content": "pain [SEP] ESCRIPTION: A 30-year-old Caucasian woman presented with dental pain, bad breath, and self-reported poor esthetics. A comprehensive ", "tokenized_content": [2, 3594, 3, 14382, 3027, 2929, 30, 43, 2627, 17, 2476, 17, 4156, 13472, 10440, 3549, 1956, 7915, 3594, 16, 11405, 8735, 16, 1930, 3543, 17, 2568, 3930, 3255, 4116, 2837, 3]}, "items": [{"id": "p_2882", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2883", "content": "bad breath [SEP] TION: A 30-year-old Caucasian woman presented with dental pain, bad breath, and self-reported poor esthetics. A comprehensive examination ", "tokenized_content": [2, 11405, 8735, 3, 8685, 1916, 30, 43, 2627, 17, 2476, 17, 4156, 13472, 10440, 3549, 1956, 7915, 3594, 16, 11405, 8735, 16, 1930, 3543, 17, 2568, 3930, 3255, 4116, 2837, 3]}, "items": [{"id": "p_2883", "content": "Respiration Disorders [SEP] Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11695, 4414, 3, 3902, 1927, 1920, 5481, 2433, 1922, 3335, 2014, 29628, 2828, 2014, 1958, 43, 2487, 5481, 2573, 2084, 3322, 18, 3]}]}
{"query": {"id": "q_2884", "content": "carious lesions [SEP] ry, panoramic radiograph, and intraoral examination revealed 19 carious lesions, which is not very common for a healthy adult. She reported her", "tokenized_content": [2, 2279, 4836, 4518, 3, 18650, 16, 3797, 8846, 4913, 20639, 16, 1930, 5153, 6277, 4981, 3404, 2282, 2279, 4836, 4518, 16, 2154, 1977, 2084, 3345, 3059, 1958, 43, 4097, 4160, 3]}, "items": [{"id": "p_2884", "content": "Dental Caries [SEP] Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic str", "score": 1, "type": null, "tokenized_content": [2, 7915, 14989, 3, 6579, 12102, 1927, 1920, 10007, 3154, 7796, 2007, 2344, 8515, 3123, 1927, 1920, 16145, 3489, 2007, 8145, 8502, 1927, 6805, 2114, 3]}]}
{"query": {"id": "q_2885", "content": "carious episodes [SEP] ethamphetamine for five years and had not experienced any major carious episodes before she started using the drug. SUMMARY: The patient's medic", "tokenized_content": [2, 2279, 4836, 9232, 3, 3293, 18996, 1958, 3628, 2739, 1930, 2430, 2084, 6090, 2967, 3044, 2279, 4836, 9232, 3119, 4693, 8074, 2193, 1920, 2838, 18, 6099, 30, 1920, 2774, 11, 3]}, "items": [{"id": "p_2885", "content": "Dental Caries [SEP] Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic str", "score": 1, "type": null, "tokenized_content": [2, 7915, 14989, 3, 6579, 12102, 1927, 1920, 10007, 3154, 7796, 2007, 2344, 8515, 3123, 1927, 1920, 16145, 3489, 2007, 8145, 8502, 1927, 6805, 2114, 3]}]}
{"query": {"id": "q_2886", "content": "methamphetamines [SEP]  practitioners recognize and manage patients who may be abusing methamphetamines. Dental practitioners also may be skeptical about the reliabili", "tokenized_content": [2, 20375, 1036, 3, 11815, 9967, 1930, 12193, 2132, 2746, 2278, 1998, 2186, 16435, 20375, 1036, 18, 7915, 11815, 2222, 2278, 1998, 3097, 17920, 1923, 3001, 1920, 4788, 3836, 1033, 3]}, "items": [{"id": "p_2886", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_2887", "content": "Thyroxine [SEP] Thyroxine abuse: an unusual case of thyrotoxicosis in pregnancy.", "tokenized_content": [2, 29423, 3, 29423, 7764, 30, 1925, 12236, 3087, 1927, 30482, 10605, 2475, 1922, 5284, 18, 3]}, "items": [{"id": "p_2887", "content": "Thyroxine [SEP] The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) an", "score": 1, "type": null, "tokenized_content": [2, 29423, 3, 1920, 3044, 6365, 3595, 2037, 1920, 6918, 8359, 18, 29423, 1977, 6653, 3454, 1920, 8594, 2636, 1927, 6941, 1036, 12, 8914, 13025, 26879, 13, 1925, 3]}]}
{"query": {"id": "q_2888", "content": "thyrotoxicosis [SEP] Thyroxine abuse: an unusual case of thyrotoxicosis in pregnancy.", "tokenized_content": [2, 30482, 10605, 2475, 3, 29423, 7764, 30, 1925, 12236, 3087, 1927, 30482, 10605, 2475, 1922, 5284, 18, 3]}, "items": [{"id": "p_2888", "content": "Thyrotoxicosis [SEP] A hypermetabolic syndrome caused by excess THYROID HORMONES which may come from endogenous or exogenous sources. The endogenous ", "score": 1, "type": null, "tokenized_content": [2, 30482, 10605, 2475, 3, 43, 13317, 9215, 4627, 3742, 4741, 4189, 2007, 5799, 6918, 10224, 2154, 2278, 10449, 2037, 5355, 2014, 8278, 5777, 18, 1920, 5355, 3]}]}
{"query": {"id": "q_2889", "content": "Eating disorders [SEP] Eating disorders and the associated behavioural problems and drug abuse are unco", "tokenized_content": [2, 8979, 4414, 3, 8979, 4414, 1930, 1920, 2458, 11581, 4951, 1930, 2838, 7764, 2032, 20732, 3]}, "items": [{"id": "p_2889", "content": "Eating Disorders [SEP] A group of disorders characterized by physiological and psychological disturbances in appetite or food intake.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8979, 4414, 3, 43, 2210, 1927, 4414, 4378, 2007, 5005, 1930, 6674, 12654, 1922, 17990, 2014, 3959, 5240, 18, 3]}]}
{"query": {"id": "q_2890", "content": "drug abuse [SEP] Eating disorders and the associated behavioural problems and drug abuse are uncommon in pregnancy. When they do occur they are often un", "tokenized_content": [2, 2838, 7764, 3, 8979, 4414, 1930, 1920, 2458, 11581, 4951, 1930, 2838, 7764, 2032, 14403, 1922, 5284, 18, 2469, 2611, 2608, 4704, 2611, 2032, 3868, 2067, 3]}, "items": [{"id": "p_2890", "content": "Substance-Related Disorders [SEP] Disorders related to substance abuse.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7311, 17, 2712, 4414, 3, 4414, 2712, 1942, 7311, 7764, 18, 3]}]}
{"query": {"id": "q_2891", "content": "eating disorders [SEP] ates a number of problems that may be encountered in women with eating disorders in pregnancy, including prolonged and recurrent metabolic distu", "tokenized_content": [2, 8979, 4414, 3, 30280, 1036, 43, 2529, 1927, 4951, 1988, 2278, 1998, 11989, 1922, 3089, 1956, 8979, 4414, 1922, 5284, 16, 2710, 7171, 1930, 7457, 4487, 3653, 1032, 3]}, "items": [{"id": "p_2891", "content": "Eating Disorders [SEP] A group of disorders characterized by physiological and psychological disturbances in appetite or food intake.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8979, 4414, 3, 43, 2210, 1927, 4414, 4378, 2007, 5005, 1930, 6674, 12654, 1922, 17990, 2014, 3959, 5240, 18, 3]}]}
{"query": {"id": "q_2892", "content": "thyrotoxicosis [SEP] omen with eating disorders and reminds us that when a cause for thyrotoxicosis remains obscure, thyroxine abuse should be considered and explo", "tokenized_content": [2, 30482, 10605, 2475, 3, 12453, 1022, 1956, 8979, 4414, 1930, 20821, 1036, 2022, 1988, 2469, 43, 3936, 1958, 30482, 10605, 2475, 4497, 24245, 16, 29423, 7764, 3066, 1998, 3311, 1930, 3]}, "items": [{"id": "p_2892", "content": "Thyrotoxicosis [SEP] A hypermetabolic syndrome caused by excess THYROID HORMONES which may come from endogenous or exogenous sources. The endogenous ", "score": 1, "type": null, "tokenized_content": [2, 30482, 10605, 2475, 3, 43, 13317, 9215, 4627, 3742, 4741, 4189, 2007, 5799, 6918, 10224, 2154, 2278, 10449, 2037, 5355, 2014, 8278, 5777, 18, 1920, 5355, 3]}]}
{"query": {"id": "q_2893", "content": "thyroxine [SEP] eminds us that when a cause for thyrotoxicosis remains obscure, thyroxine abuse should be considered and explored.", "tokenized_content": [2, 29423, 3, 2391, 2762, 1036, 2022, 1988, 2469, 43, 3936, 1958, 30482, 10605, 2475, 4497, 24245, 16, 29423, 7764, 3066, 1998, 3311, 1930, 7255, 18, 3]}, "items": [{"id": "p_2893", "content": "Thyroxine [SEP] The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) an", "score": 1, "type": null, "tokenized_content": [2, 29423, 3, 1920, 3044, 6365, 3595, 2037, 1920, 6918, 8359, 18, 29423, 1977, 6653, 3454, 1920, 8594, 2636, 1927, 6941, 1036, 12, 8914, 13025, 26879, 13, 1925, 3]}]}
{"query": {"id": "q_2894", "content": "methamphetamine [SEP] Attenuation of methamphetamine-induced nigrostriatal dopaminergic neurotoxicity in mice by lip", "tokenized_content": [2, 20375, 3, 10961, 1927, 20375, 17, 2719, 17452, 17414, 21195, 12214, 18034, 1922, 2518, 2007, 3178, 3]}, "items": [{"id": "p_2894", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_2895", "content": "neurotoxicity [SEP] tenuation of methamphetamine-induced nigrostriatal dopaminergic neurotoxicity in mice by lipopolysaccharide pretreatment.", "tokenized_content": [2, 18034, 3, 5656, 10874, 1927, 20375, 17, 2719, 17452, 17414, 21195, 12214, 18034, 1922, 2518, 2007, 15614, 9111, 18, 3]}, "items": [{"id": "p_2895", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2896", "content": "lipopolysaccharide [SEP] ine-induced nigrostriatal dopaminergic neurotoxicity in mice by lipopolysaccharide pretreatment.", "tokenized_content": [2, 15614, 3, 11116, 17, 2719, 17452, 17414, 21195, 12214, 18034, 1922, 2518, 2007, 15614, 9111, 18, 3]}, "items": [{"id": "p_2896", "content": "Lipopolysaccharides [SEP] Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cel", "score": 1, "type": null, "tokenized_content": [2, 15614, 1036, 3, 4486, 17, 3165, 18686, 2154, 2032, 16366, 1036, 1930, 2715, 2210, 17, 2487, 7769, 18, 2611, 2032, 3868, 3595, 2037, 1920, 15765, 3]}]}
{"query": {"id": "q_2897", "content": "methamphetamine [SEP] Immunological activation has been proposed to play a role in methamphetamine-induced dopaminergic terminal damage. In this study, we examine", "tokenized_content": [2, 20375, 3, 11611, 2936, 2258, 2252, 4211, 1942, 3918, 43, 2770, 1922, 20375, 17, 2719, 12214, 4262, 4293, 18, 1922, 2052, 2161, 16, 2038, 5020, 3]}, "items": [{"id": "p_2897", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_2898", "content": "dopaminergic terminal damage [SEP] ion has been proposed to play a role in methamphetamine-induced dopaminergic terminal damage. In this study, we examined the roles of lipopolysaccharide, a ", "tokenized_content": [2, 12214, 4262, 4293, 3, 4755, 2258, 2252, 4211, 1942, 3918, 43, 2770, 1922, 20375, 17, 2719, 12214, 4262, 4293, 18, 1922, 2052, 2161, 16, 2038, 3572, 1920, 5456, 1927, 15614, 3]}, "items": [{"id": "p_2898", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_2899", "content": "lipopolysaccharide [SEP] nergic terminal damage. In this study, we examined the roles of lipopolysaccharide, a pro-inflammatory and inflammatory factor, treatment in modul", "tokenized_content": [2, 15614, 3, 4919, 11545, 4262, 4293, 18, 1922, 2052, 2161, 16, 2038, 3572, 1920, 5456, 1927, 15614, 16, 43, 1965, 17, 3769, 1930, 3769, 2991, 16, 2311, 1922, 7286, 3]}, "items": [{"id": "p_2899", "content": "Lipopolysaccharides [SEP] Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cel", "score": 1, "type": null, "tokenized_content": [2, 15614, 1036, 3, 4486, 17, 3165, 18686, 2154, 2032, 16366, 1036, 1930, 2715, 2210, 17, 2487, 7769, 18, 2611, 2032, 3868, 3595, 2037, 1920, 15765, 3]}]}
{"query": {"id": "q_2900", "content": "dopamine [SEP] ion has been proposed to play a role in methamphetamine-induced dopaminergic terminal damage. In this study, we examined the roles of li", "tokenized_content": [2, 7964, 3, 4755, 2258, 2252, 4211, 1942, 3918, 43, 2770, 1922, 20375, 17, 2719, 12214, 4262, 4293, 18, 1922, 2052, 2161, 16, 2038, 3572, 1920, 5456, 1927, 2336, 3]}, "items": [{"id": "p_2900", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_2901", "content": "neurotoxicity [SEP] n modulating the methamphetamine-induced nigrostriatal dopamine neurotoxicity. Lipopolysaccharide pretreatment did not affect the basal body ", "tokenized_content": [2, 18034, 3, 56, 10871, 1920, 20375, 17, 2719, 17452, 17414, 21195, 7964, 18034, 18, 15614, 9111, 2811, 2084, 4081, 1920, 5342, 3362, 3]}, "items": [{"id": "p_2901", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_2902", "content": "Lipopolysaccharide [SEP] e methamphetamine-induced nigrostriatal dopamine neurotoxicity. Lipopolysaccharide pretreatment did not affect the basal body temperature or metha", "tokenized_content": [2, 15614, 3, 47, 20375, 17, 2719, 17452, 17414, 21195, 7964, 18034, 18, 15614, 9111, 2811, 2084, 4081, 1920, 5342, 3362, 3449, 2014, 2295, 1019, 3]}, "items": [{"id": "p_2902", "content": "Lipopolysaccharides [SEP] Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cel", "score": 1, "type": null, "tokenized_content": [2, 15614, 1036, 3, 4486, 17, 3165, 18686, 2154, 2032, 16366, 1036, 1930, 2715, 2210, 17, 2487, 7769, 18, 2611, 2032, 3868, 3595, 2037, 1920, 15765, 3]}]}
{"query": {"id": "q_2903", "content": "hyperthermia [SEP] t affect the basal body temperature or methamphetamine-elicited hyperthermia three days later. Such systemic lipopolysaccharide treatment mi", "tokenized_content": [2, 21945, 3, 62, 4081, 1920, 5342, 3362, 3449, 2014, 20375, 17, 9856, 21945, 2559, 3000, 3690, 18, 2427, 5510, 15614, 2311, 6519, 3]}, "items": [{"id": "p_2903", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_2904", "content": "3,4-dihydroxyphenylacetic acid [SEP] eatment mitigated methamphetamine-induced striatal dopamine and 3,4-dihydroxyphenylacetic acid depletions in a dose-dependent manner. As the most potent dose ", "tokenized_content": [2, 23, 16, 24, 17, 20684, 17616, 2199, 13722, 2687, 3, 13619, 2017, 27519, 20375, 17, 2719, 13165, 7964, 1930, 23, 16, 24, 17, 20684, 17616, 2199, 13722, 2687, 6882, 1036, 3]}, "items": [{"id": "p_2904", "content": "3,4-Dihydroxyphenylacetic Acid [SEP] A deaminated metabolite of LEVODOPA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23, 16, 24, 17, 20684, 17616, 2199, 13722, 2687, 3, 43, 30097, 8547, 1981, 9483, 1927, 26723, 18, 3]}]}
{"query": {"id": "q_2905", "content": "adriamycin [SEP] Effect of converting enzyme inhibition on the course of adriamycin-induced nephropathy.", "tokenized_content": [2, 25622, 7898, 3, 2495, 1927, 15025, 4113, 3523, 1990, 1920, 4914, 1927, 25622, 7898, 17, 2719, 15582, 18, 3]}, "items": [{"id": "p_2905", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2906", "content": "nephropathy [SEP] onverting enzyme inhibition on the course of adriamycin-induced nephropathy.", "tokenized_content": [2, 15582, 3, 1990, 22212, 1941, 4113, 3523, 1990, 1920, 4914, 1927, 25622, 7898, 17, 2719, 15582, 18, 3]}, "items": [{"id": "p_2906", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2907", "content": "enalapril [SEP] The effect of the converting enzyme inhibitor (CEI) enalapril was assessed in Munich-Wistar rats with established adriamycin ", "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 1920, 2495, 1927, 1920, 15025, 4113, 4106, 12, 5827, 1033, 13, 2066, 8056, 2047, 1970, 1982, 3683, 1922, 28967, 17, 15668, 3615, 1956, 4379, 25622, 3]}, "items": [{"id": "p_2907", "content": "Enalapril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 1988, 1977, 2251, 1942, 2297, 5579, 18, 3]}]}
{"query": {"id": "q_2908", "content": "adriamycin [SEP] ) enalapril was assessed in Munich-Wistar rats with established adriamycin nephrosis. Rats were given a single dose of adriamycin and one ", "tokenized_content": [2, 25622, 7898, 3, 13, 2066, 8056, 2047, 1970, 1982, 3683, 1922, 28967, 17, 15668, 3615, 1956, 4379, 25622, 7898, 7737, 4870, 18, 3615, 1985, 3258, 43, 2957, 3253, 1927, 25622, 3]}, "items": [{"id": "p_2908", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_2909", "content": "nephrosis [SEP]  was assessed in Munich-Wistar rats with established adriamycin nephrosis. Rats were given a single dose of adriamycin and one month late", "tokenized_content": [2, 7737, 4870, 3, 1982, 3683, 1922, 28967, 17, 15668, 3615, 1956, 4379, 25622, 7898, 7737, 4870, 18, 3615, 1985, 3258, 43, 2957, 3253, 1927, 25622, 7898, 1930, 2340, 2935, 5058, 3]}, "items": [{"id": "p_2909", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_2910", "content": "albuminuria [SEP] amycin and one month later divided into four groups matched for albuminuria, blood pressure, and plasma albumin concentration. Groups 1 and", "tokenized_content": [2, 24962, 3, 20306, 3665, 1930, 2340, 2935, 3690, 5831, 2460, 3006, 2671, 5992, 1958, 24962, 16, 2877, 3772, 16, 1930, 3582, 7712, 3110, 18, 2671, 21, 1930, 3]}, "items": [{"id": "p_2910", "content": "Albuminuria [SEP] The presence of albumin in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24962, 3, 1920, 2990, 1927, 7712, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_2911", "content": "renal injury [SEP]  six months to assess the effect of enalapril on progression of renal injury in adriamycin nephrosis. Chronic enalapril treatment reduced bl", "tokenized_content": [2, 4604, 4047, 3, 3798, 3221, 1942, 2634, 1920, 2495, 1927, 2066, 8056, 2047, 1970, 1990, 4380, 1927, 4604, 4047, 1922, 25622, 7898, 7737, 4870, 18, 3724, 2066, 8056, 2047, 1970, 3]}, "items": [{"id": "p_2911", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2912", "content": "Enalapril [SEP] +/- 0.08 ml/min at 4 months, 0.27 +/- 0.07 ml/min at 6 months). Enalapril treatment blunted but did not prevent reduction in GFR in group", "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 15, 19, 17, 20, 18, 6709, 2646, 19, 2360, 2019, 24, 3221, 16, 20, 18, 3225, 15, 19, 17, 20, 18, 6627, 2646, 19, 2360, 3]}, "items": [{"id": "p_2912", "content": "Enalapril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 1988, 1977, 2251, 1942, 2297, 5579, 18, 3]}]}
{"query": {"id": "q_2913", "content": "glomerular sclerosis [SEP] oup 3). Reduction in GFR was associated with the development of glomerular sclerosis in both treated and untreated rats.(ABSTRACT TRUNCATED AT 250 W", "tokenized_content": [2, 11655, 11484, 3, 17208, 1034, 23, 13, 18, 3378, 1922, 15316, 1982, 2458, 1956, 1920, 2740, 1927, 11655, 11484, 1922, 2321, 2868, 1930, 6829, 3615, 18, 12, 10929, 9530, 2019, 3]}, "items": [{"id": "p_2913", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_2914", "content": "apnea [SEP] Butyrylcholinesterase gene mutations in patients with prolonged apnea after succinylcholine for electroconvulsive therapy.", "tokenized_content": [2, 17578, 3, 2308, 28822, 27556, 2359, 3527, 1922, 2132, 1956, 7171, 17578, 2256, 13791, 2199, 11603, 1958, 13142, 12766, 13042, 3181, 18, 3]}, "items": [{"id": "p_2914", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_2915", "content": "succinylcholine [SEP] nesterase gene mutations in patients with prolonged apnea after succinylcholine for electroconvulsive therapy.", "tokenized_content": [2, 13791, 2199, 11603, 3, 15681, 7124, 4127, 2359, 3527, 1922, 2132, 1956, 7171, 17578, 2256, 13791, 2199, 11603, 1958, 13142, 12766, 13042, 3181, 18, 3]}, "items": [{"id": "p_2915", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_2916", "content": "succinylcholine [SEP] tients undergoing electroconvulsive therapy (ECT) often receive succinylcholine as part of the anesthetic procedure. The duration of action may", "tokenized_content": [2, 13791, 2199, 11603, 3, 19108, 4905, 1036, 7258, 13142, 12766, 13042, 3181, 12, 7495, 13, 3868, 7130, 13791, 2199, 11603, 1966, 3131, 1927, 1920, 16111, 4360, 18, 1920, 4392, 1927, 3]}, "items": [{"id": "p_2916", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_2917", "content": "apnea [SEP]  BCHE genotype using molecular genetic methods, the duration of apnea, time to sufficient spontaneous ventilation and whether neuromu", "tokenized_content": [2, 17578, 3, 6452, 4116, 5619, 2193, 3272, 3299, 2860, 16, 1920, 4392, 1927, 17578, 16, 2367, 1942, 5409, 6242, 10198, 1930, 3053, 11408, 1032, 3]}, "items": [{"id": "p_2917", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_2918", "content": "Ketamine [SEP] Ketamine sedation for the reduction of children's fractures in the emerg", "tokenized_content": [2, 14049, 3, 14049, 15263, 1958, 1920, 3378, 1927, 3069, 11, 61, 9018, 1922, 1920, 4492, 3]}, "items": [{"id": "p_2918", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2919", "content": "fractures [SEP] Ketamine sedation for the reduction of children's fractures in the emergency department.", "tokenized_content": [2, 9018, 3, 14049, 15263, 1958, 1920, 3378, 1927, 3069, 11, 61, 9018, 1922, 1920, 7877, 6143, 18, 3]}, "items": [{"id": "p_2919", "content": "Fractures, Bone [SEP] Breaks in bones.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9018, 16, 3622, 3, 13065, 1922, 14153, 18, 3]}]}
{"query": {"id": "q_2920", "content": "ketamine [SEP] UND: There recently has been a resurgence in the utilization of ketamine, a unique anesthetic, for emergency-department procedures requi", "tokenized_content": [2, 14049, 3, 3075, 30, 2276, 3998, 2258, 2252, 43, 1995, 28562, 15895, 1021, 1922, 1920, 8422, 1927, 14049, 16, 43, 5008, 16111, 16, 1958, 7877, 17, 6143, 4869, 2721, 1033, 3]}, "items": [{"id": "p_2920", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2921", "content": "fractures [SEP] fficacy of ketamine for sedation in the treatment of children's fractures in the emergency department. METHODS: One hundred and fourteen ", "tokenized_content": [2, 9018, 3, 10735, 6102, 13796, 1927, 14049, 1958, 15263, 1922, 1920, 2311, 1927, 3069, 11, 61, 9018, 1922, 1920, 7877, 6143, 18, 2860, 30, 2340, 8295, 1930, 18032, 3]}, "items": [{"id": "p_2921", "content": "Fractures, Bone [SEP] Breaks in bones.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9018, 16, 3622, 3, 13065, 1922, 14153, 18, 3]}]}
{"query": {"id": "q_2922", "content": "fracture [SEP] fficacy of ketamine for sedation in the treatment of children's fractures in the emergency department. METHODS: One hundred and fourteen", "tokenized_content": [2, 7515, 3, 10735, 6102, 13796, 1927, 14049, 1958, 15263, 1922, 1920, 2311, 1927, 3069, 11, 61, 9018, 1922, 1920, 7877, 6143, 18, 2860, 30, 2340, 8295, 1930, 18032, 3]}, "items": [{"id": "p_2922", "content": "Fractures, Bone [SEP] Breaks in bones.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9018, 16, 3622, 3, 13065, 1922, 14153, 18, 3]}]}
{"query": {"id": "q_2923", "content": "dislocation [SEP] nths) who underwent closed reduction of an isolated fracture or dislocation in the emergency department at a level-I trauma center were pro", "tokenized_content": [2, 16939, 3, 5891, 8092, 13, 2746, 5468, 8047, 3378, 1927, 1925, 3937, 7515, 2014, 16939, 1922, 1920, 7877, 6143, 2019, 43, 2237, 17, 51, 7176, 4102, 1985, 1965, 3]}, "items": [{"id": "p_2923", "content": "Dislocations [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16939, 1036, 3, 3]}]}
{"query": {"id": "q_2924", "content": "trauma [SEP] racture or dislocation in the emergency department at a level-I trauma center were prospectively evaluated. Ketamine hydrochloride was", "tokenized_content": [2, 7176, 3, 7195, 4040, 2014, 16939, 1922, 1920, 7877, 6143, 2019, 43, 2237, 17, 51, 7176, 4102, 1985, 12439, 3747, 18, 14049, 16675, 1982, 3]}, "items": [{"id": "p_2924", "content": "Wounds and Injuries [SEP] Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural con", "score": 1, "type": null, "tokenized_content": [2, 14107, 1930, 8209, 3, 4293, 2552, 5847, 1919, 1990, 1920, 3362, 1966, 1920, 3083, 2014, 6354, 3211, 1927, 1925, 5771, 5495, 16, 1956, 2014, 2979, 7561, 1927, 4346, 1962, 3]}]}
{"query": {"id": "q_2925", "content": "Ketamine hydrochloride [SEP] rtment at a level-I trauma center were prospectively evaluated. Ketamine hydrochloride was administered intravenously (at a dose of two milligrams per", "tokenized_content": [2, 14049, 16675, 3, 4341, 2017, 2019, 43, 2237, 17, 51, 7176, 4102, 1985, 12439, 3747, 18, 14049, 16675, 1982, 5254, 15132, 12, 2019, 43, 3253, 1927, 2288, 4736, 3770, 4645, 3]}, "items": [{"id": "p_2925", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2926", "content": "pain [SEP] tic, and the patients were monitored by a registered nurse. Any pain during the reduction was rated by the orthopaedic surgeon treat", "tokenized_content": [2, 3594, 3, 18298, 16, 1930, 1920, 2132, 1985, 7027, 2007, 43, 10012, 10768, 18, 2967, 3594, 2409, 1920, 3378, 1982, 10036, 2007, 1920, 22333, 12360, 2297, 3]}, "items": [{"id": "p_2926", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2927", "content": "Pain [SEP] patient according to the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS). RESULTS: The average time from intravenous admi", "tokenized_content": [2, 3594, 3, 2774, 3147, 1942, 1920, 3069, 11, 61, 3461, 1927, 11562, 18267, 3594, 3536, 12, 10003, 4001, 13, 18, 2274, 30, 1920, 3361, 2367, 2037, 7307, 3034, 1033, 3]}, "items": [{"id": "p_2927", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2928", "content": "nausea [SEP] ure and heart rate remained stable. Minor side effects included nausea (thirteen patients), emesis (eight of the thirteen patients wit", "tokenized_content": [2, 13759, 3, 6794, 1930, 4003, 2769, 5410, 4700, 18, 5857, 4159, 2564, 3063, 13759, 12, 18468, 2132, 13, 16, 2391, 2600, 12, 5066, 1927, 1920, 18468, 2132, 16086, 3]}, "items": [{"id": "p_2928", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_2929", "content": "emesis [SEP] stable. Minor side effects included nausea (thirteen patients), emesis (eight of the thirteen patients with nausea), clumsiness (evide", "tokenized_content": [2, 2391, 2600, 3, 4700, 18, 5857, 4159, 2564, 3063, 13759, 12, 18468, 2132, 13, 16, 2391, 2600, 12, 5066, 1927, 1920, 18468, 2132, 1956, 13759, 13, 16, 2111, 22627, 8254, 3]}, "items": [{"id": "p_2929", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_2930", "content": "clumsiness [SEP] patients), emesis (eight of the thirteen patients with nausea), clumsiness (evident as ataxic movements in ten patients), and dysphoric re", "tokenized_content": [2, 2111, 22627, 8254, 3, 2132, 13, 16, 2391, 2600, 12, 5066, 1927, 1920, 18468, 2132, 1956, 13759, 13, 16, 2111, 22627, 8254, 12, 7501, 1966, 15383, 1935, 8264, 1922, 5656, 3]}, "items": [{"id": "p_2930", "content": "Ataxia [SEP] Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes,", "score": 1, "type": null, "tokenized_content": [2, 17698, 3, 6159, 1927, 1920, 3682, 1942, 2385, 6689, 1954, 11651, 13225, 8264, 18, 2052, 2625, 2278, 4081, 1920, 14054, 16, 13717, 16, 7127, 16, 3]}]}
{"query": {"id": "q_2931", "content": "ataxic movements [SEP] t of the thirteen patients with nausea), clumsiness (evident as ataxic movements in ten patients), and dysphoric reaction (one patient). No long", "tokenized_content": [2, 15383, 1935, 8264, 3, 62, 1927, 1920, 18468, 2132, 1956, 13759, 13, 16, 2111, 22627, 8254, 12, 7501, 1966, 15383, 1935, 8264, 1922, 5656, 2132, 13, 16, 1930, 17156, 18151, 3]}, "items": [{"id": "p_2931", "content": "Ataxia [SEP] Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes,", "score": 1, "type": null, "tokenized_content": [2, 17698, 3, 6159, 1927, 1920, 3682, 1942, 2385, 6689, 1954, 11651, 13225, 8264, 18, 2052, 2625, 2278, 4081, 1920, 14054, 16, 13717, 16, 7127, 16, 3]}]}
{"query": {"id": "q_2932", "content": "hallucinations [SEP] patient). No long-term sequelae were noted, and no patients had hallucinations or nightmares. CONCLUSIONS: Ketamine reliably, safely, and quic", "tokenized_content": [2, 27013, 3, 2774, 13, 18, 2239, 2815, 17, 2576, 19067, 1985, 5040, 16, 1930, 2239, 2132, 2430, 27013, 2014, 9609, 19252, 1918, 18, 4355, 30, 14049, 13445, 16, 17587, 16, 3]}, "items": [{"id": "p_2932", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_2933", "content": "Ketamine [SEP] rtment at a level-I trauma center were prospectively evaluated. Ketamine hydrochloride was administered intravenously (at a dose of two ", "tokenized_content": [2, 14049, 3, 4341, 2017, 2019, 43, 2237, 17, 51, 7176, 4102, 1985, 12439, 3747, 18, 14049, 16675, 1982, 5254, 15132, 12, 2019, 43, 3253, 1927, 2288, 3]}, "items": [{"id": "p_2933", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_2934", "content": "lamivudine [SEP] Prophylactic use of lamivudine with chronic immunosuppressive therapy for rheumatologic disord", "tokenized_content": [2, 30208, 3, 14847, 2485, 1927, 30208, 1956, 3724, 12910, 3181, 1958, 10939, 4467, 2054, 2538, 3]}, "items": [{"id": "p_2934", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_2935", "content": "rheumatologic disorders [SEP] ic use of lamivudine with chronic immunosuppressive therapy for rheumatologic disorders.", "tokenized_content": [2, 10939, 4467, 4414, 3, 3996, 2485, 1927, 30208, 1956, 3724, 12910, 3181, 1958, 10939, 4467, 4414, 18, 3]}, "items": [{"id": "p_2935", "content": "Rheumatic Diseases [SEP] Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or me", "score": 1, "type": null, "tokenized_content": [2, 22806, 3902, 3, 4414, 1927, 14948, 2960, 16, 4369, 1920, 12648, 1930, 2712, 4061, 16, 4378, 2007, 4531, 16, 9174, 16, 2014, 2142, 3]}]}
{"query": {"id": "q_2936", "content": "lamivudine [SEP] cerning the effectiveness of the prophylactic administration of lamivudine in hepatitis B virus surface antigen (HBs Ag) positive patients", "tokenized_content": [2, 30208, 3, 6580, 2989, 1920, 6001, 1927, 1920, 14847, 4183, 1927, 30208, 1922, 7977, 44, 3413, 3154, 4730, 12, 11500, 2260, 13, 2843, 2132, 3]}, "items": [{"id": "p_2936", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_2937", "content": "hepatitis B virus surface antigen [SEP] fectiveness of the prophylactic administration of lamivudine in hepatitis B virus surface antigen (HBs Ag) positive patients with rheumatologic disease. From Jun", "tokenized_content": [2, 7977, 44, 3413, 3154, 4730, 3, 16688, 24770, 1927, 1920, 14847, 4183, 1927, 30208, 1922, 7977, 44, 3413, 3154, 4730, 12, 11500, 2260, 13, 2843, 2132, 1956, 10939, 4467, 2573, 3]}, "items": [{"id": "p_2937", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_2938", "content": "HBs Ag [SEP] inistration of lamivudine in hepatitis B virus surface antigen (HBs Ag) positive patients with rheumatologic disease. From June 2004 t", "tokenized_content": [2, 11500, 2260, 3, 1922, 3934, 1927, 30208, 1922, 7977, 44, 3413, 3154, 4730, 12, 11500, 2260, 13, 2843, 2132, 1956, 10939, 4467, 2573, 18, 2037, 10343, 4247, 62, 3]}, "items": [{"id": "p_2938", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_2939", "content": "rheumatologic disease [SEP] patitis B virus surface antigen (HBs Ag) positive patients with rheumatologic disease. From June 2004 to October 2006, 11 HBs Ag positive patients wi", "tokenized_content": [2, 10939, 4467, 2573, 3, 2091, 3600, 44, 3413, 3154, 4730, 12, 11500, 2260, 13, 2843, 2132, 1956, 10939, 4467, 2573, 18, 2037, 10343, 4247, 1942, 11722, 3956, 16, 2513, 11500, 3]}, "items": [{"id": "p_2939", "content": "Rheumatic Diseases [SEP] Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or me", "score": 1, "type": null, "tokenized_content": [2, 22806, 3902, 3, 4414, 1927, 14948, 2960, 16, 4369, 1920, 12648, 1930, 2712, 4061, 16, 4378, 2007, 4531, 16, 9174, 16, 2014, 2142, 3]}]}
{"query": {"id": "q_2940", "content": "rheumatologic diseases [SEP] rom June 2004 to October 2006, 11 HBs Ag positive patients with rheumatologic diseases, who were on both immunosuppressive and prophylactic lamivudine", "tokenized_content": [2, 10939, 4467, 3902, 3, 15612, 10343, 4247, 1942, 11722, 3956, 16, 2513, 11500, 2260, 2843, 2132, 1956, 10939, 4467, 3902, 16, 2746, 1985, 1990, 2321, 12910, 1930, 14847, 30208, 3]}, "items": [{"id": "p_2940", "content": "Rheumatic Diseases [SEP] Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or me", "score": 1, "type": null, "tokenized_content": [2, 22806, 3902, 3, 4414, 1927, 14948, 2960, 16, 4369, 1920, 12648, 1930, 2712, 4061, 16, 4378, 2007, 4531, 16, 9174, 16, 2014, 2142, 3]}]}
{"query": {"id": "q_2941", "content": "hepatitis B [SEP] fectiveness of the prophylactic administration of lamivudine in hepatitis B virus surface antigen (HBs Ag) positive patients with rheumatol", "tokenized_content": [2, 7977, 44, 3, 16688, 24770, 1927, 1920, 14847, 4183, 1927, 30208, 1922, 7977, 44, 3413, 3154, 4730, 12, 11500, 2260, 13, 2843, 2132, 1956, 10939, 1945, 3]}, "items": [{"id": "p_2941", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_2942", "content": "Lamivudine [SEP]  patients 13.8 months (range 5-27) were enrolled in this study. Lamivudine therapy was started 3-7 days prior to immunosuppressive therapy", "tokenized_content": [2, 30208, 3, 2132, 2590, 18, 28, 3221, 12, 3109, 25, 17, 3225, 13, 1985, 7316, 1922, 2052, 2161, 18, 30208, 3181, 1982, 8074, 23, 17, 27, 3000, 3432, 1942, 12910, 3]}, "items": [{"id": "p_2942", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_2943", "content": "abnormal liver function [SEP] normalized and during follow-up period none of the patients had abnormal liver function tests. In four patients HBV DNA levels were higher than normal ", "tokenized_content": [2, 4552, 3568, 2347, 3, 5766, 1930, 2409, 2396, 17, 2353, 3047, 6046, 1927, 1920, 2132, 2430, 4552, 3568, 2347, 4026, 18, 1922, 3006, 2132, 8738, 2678, 2428, 1985, 2580, 2254, 3]}, "items": [{"id": "p_2943", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_2944", "content": "Midazolan [SEP] TIVE: to analyze aspects of TEE safety associated to the use of Midazolan (MZ) and Flumazenil (FL) and the influence of the clinical vari", "tokenized_content": [2, 3953, 10457, 1928, 3, 8685, 1961, 30, 1942, 7125, 6082, 1927, 27046, 5407, 2458, 1942, 1920, 2485, 1927, 3953, 10457, 1928, 12, 15927, 13, 1930, 2848, 3368, 7490, 1970, 12, 3]}, "items": [{"id": "p_2944", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_2945", "content": "MZ [SEP] alyze aspects of TEE safety associated to the use of Midazolan (MZ) and Flumazenil (FL) and the influence of the clinical variable", "tokenized_content": [2, 15927, 3, 1969, 2904, 1021, 6082, 1927, 27046, 5407, 2458, 1942, 1920, 2485, 1927, 3953, 10457, 1928, 12, 15927, 13, 1930, 2848, 3368, 7490, 1970, 12, 2300, 13, 1930, 1920, 3]}, "items": [{"id": "p_2945", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_2946", "content": "Flumazenil [SEP] pects of TEE safety associated to the use of Midazolan (MZ) and Flumazenil (FL) and the influence of the clinical variables on the event r", "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 13494, 1973, 1927, 27046, 5407, 2458, 1942, 1920, 2485, 1927, 3953, 10457, 1928, 12, 15927, 13, 1930, 2848, 3368, 7490, 1970, 12, 2300, 13, 1930, 3]}, "items": [{"id": "p_2946", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_2947", "content": "FL [SEP]  safety associated to the use of Midazolan (MZ) and Flumazenil (FL) and the influence of the clinical variables on the event rate.", "tokenized_content": [2, 2300, 3, 5407, 2458, 1942, 1920, 2485, 1927, 3953, 10457, 1928, 12, 15927, 13, 1930, 2848, 3368, 7490, 1970, 12, 2300, 13, 1930, 1920, 4039, 1927, 1920, 2535, 3832, 1990, 3]}, "items": [{"id": "p_2947", "content": "Flumazenil [SEP] A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been su", "score": 1, "type": null, "tokenized_content": [2, 2848, 3368, 7490, 1970, 3, 43, 6828, 27266, 3148, 8151, 18, 3328, 2176, 28817, 1920, 28514, 1930, 2303, 7728, 1927, 26555, 16, 2176, 2258, 2252, 2020, 3]}]}
{"query": {"id": "q_2948", "content": "stroke [SEP] used to test the influence of the clinical variables: age, sex, stroke, myocardiopathy (MP), duration of the test, mitral regurgitatio", "tokenized_content": [2, 5235, 3, 2251, 1942, 2648, 1920, 4039, 1927, 1920, 2535, 3832, 30, 2632, 16, 3486, 16, 5235, 16, 5779, 22788, 15935, 12, 5438, 13, 16, 4392, 1927, 1920, 2648, 16, 3]}, "items": [{"id": "p_2948", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_2949", "content": "myocardiopathy [SEP] test the influence of the clinical variables: age, sex, stroke, myocardiopathy (MP), duration of the test, mitral regurgitation (MR) and the M", "tokenized_content": [2, 5779, 22788, 15935, 3, 2648, 1920, 4039, 1927, 1920, 2535, 3832, 30, 2632, 16, 3486, 16, 5235, 16, 5779, 22788, 15935, 12, 5438, 13, 16, 4392, 1927, 1920, 2648, 16, 3]}, "items": [{"id": "p_2949", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_2950", "content": "MP [SEP] ce of the clinical variables: age, sex, stroke, myocardiopathy (MP), duration of the test, mitral regurgitation (MR) and the MZ do", "tokenized_content": [2, 5438, 3, 5827, 1927, 1920, 2535, 3832, 30, 2632, 16, 3486, 16, 5235, 16, 5779, 22788, 15935, 12, 5438, 13, 16, 4392, 1927, 1920, 2648, 16, 13868, 20198, 12, 2852, 3]}, "items": [{"id": "p_2950", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_2951", "content": "mitral regurgitation [SEP] s: age, sex, stroke, myocardiopathy (MP), duration of the test, mitral regurgitation (MR) and the MZ dose. RESULTS: All patients (65+/-16 yrs; 58% m", "tokenized_content": [2, 13868, 20198, 3, 61, 30, 2632, 16, 3486, 16, 5235, 16, 5779, 22788, 15935, 12, 5438, 13, 16, 4392, 1927, 1920, 2648, 16, 13868, 20198, 12, 2852, 13, 1930, 1920, 3]}, "items": [{"id": "p_2951", "content": "Mitral Valve Insufficiency [SEP] Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mi", "score": 1, "type": null, "tokenized_content": [2, 13868, 9509, 14566, 3, 3231, 9893, 1927, 2877, 2037, 1920, 3506, 11887, 2460, 1920, 3506, 20548, 2810, 1942, 23344, 10408, 1927, 1920, 13868, 9509, 18, 2052, 2112, 2949, 1942, 6519, 3]}]}
{"query": {"id": "q_2952", "content": "MR [SEP] yocardiopathy (MP), duration of the test, mitral regurgitation (MR) and the MZ dose. RESULTS: All patients (65+/-16 yrs; 58% males", "tokenized_content": [2, 2852, 3, 7419, 15339, 7408, 6522, 12, 5438, 13, 16, 4392, 1927, 1920, 2648, 16, 13868, 20198, 12, 2852, 13, 1930, 1920, 15927, 3253, 18, 2274, 30, 2136, 2132, 12, 3]}, "items": [{"id": "p_2952", "content": "Mitral Valve Insufficiency [SEP] Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mi", "score": 1, "type": null, "tokenized_content": [2, 13868, 9509, 14566, 3, 3231, 9893, 1927, 2877, 2037, 1920, 3506, 11887, 2460, 1920, 3506, 20548, 2810, 1942, 23344, 10408, 1927, 1920, 13868, 9509, 18, 2052, 2112, 2949, 1942, 6519, 3]}]}
{"query": {"id": "q_2953", "content": "hypoxia [SEP] on (EF) were 16.4+/-6.1 minutes and 60+/-9%, respectively. Mild hypoxia (SO2<90%) was the most common event (11 patients); 3 patients (", "tokenized_content": [2, 7264, 3, 1990, 12, 8485, 13, 1985, 2641, 18, 24, 15, 19, 17, 26, 18, 21, 4814, 1930, 3276, 15, 19, 17, 29, 9, 16, 2763, 18, 5809, 7264, 12, 3]}, "items": [{"id": "p_2953", "content": "Anoxia [SEP] Relatively complete absence of oxygen in one or more tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28976, 18068, 1019, 3, 4322, 4080, 3905, 1927, 4612, 1922, 2340, 2014, 2253, 3878, 18, 3]}]}
{"query": {"id": "q_2954", "content": "airway obstruction [SEP] ents); 3 patients (2%) presented transient hypoxia due to upper airway obstruction by probe introduction and 8 (5.8%) due to hypoxia caused by MZ ", "tokenized_content": [2, 8155, 10849, 3, 8496, 1036, 13, 31, 23, 2132, 12, 22, 9, 13, 3549, 6809, 7264, 2810, 1942, 5199, 8155, 10849, 2007, 5598, 6935, 1930, 28, 12, 25, 18, 28, 3]}, "items": [{"id": "p_2954", "content": "Airway Obstruction [SEP] Any hindrance to the passage of air into and out of the lungs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8155, 10849, 3, 2967, 28831, 1942, 1920, 11008, 1927, 4433, 2460, 1930, 2397, 1927, 1920, 9193, 18, 3]}]}
{"query": {"id": "q_2955", "content": "hypotension [SEP] duction and 8 (5.8%) due to hypoxia caused by MZ use. Transient hypotension (SAP<90mmHg) occurred in 1 patient (0.7%). The multivariate ana", "tokenized_content": [2, 16453, 3, 10840, 2001, 1930, 28, 12, 25, 18, 28, 9, 13, 2810, 1942, 7264, 4189, 2007, 15927, 2485, 18, 6809, 16453, 12, 9235, 32, 3865, 7445, 7998, 13, 4807, 3]}, "items": [{"id": "p_2955", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_2956", "content": "calcium [SEP] Effects of calcium channel blockers on bupivacaine-induced toxicity.", "tokenized_content": [2, 5016, 3, 2564, 1927, 5016, 4999, 13628, 1990, 25473, 17, 2719, 5532, 18, 3]}, "items": [{"id": "p_2956", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2957", "content": "bupivacaine [SEP] Effects of calcium channel blockers on bupivacaine-induced toxicity.", "tokenized_content": [2, 25473, 3, 2564, 1927, 5016, 4999, 13628, 1990, 25473, 17, 2719, 5532, 18, 3]}, "items": [{"id": "p_2957", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_2958", "content": "toxicity [SEP] Effects of calcium channel blockers on bupivacaine-induced toxicity.", "tokenized_content": [2, 5532, 3, 2564, 1927, 5016, 4999, 13628, 1990, 25473, 17, 2719, 5532, 18, 3]}, "items": [{"id": "p_2958", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2959", "content": "calcium [SEP] The purpose of this study was to investigate the influence of calcium channel blockers on bupivacaine-induced acute toxicity. For eac", "tokenized_content": [2, 5016, 3, 1920, 5120, 1927, 2052, 2161, 1982, 1942, 4482, 1920, 4039, 1927, 5016, 4999, 13628, 1990, 25473, 17, 2719, 3939, 5532, 18, 1958, 27848, 3]}, "items": [{"id": "p_2959", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_2960", "content": "bupivacaine [SEP] was to investigate the influence of calcium channel blockers on bupivacaine-induced acute toxicity. For each of the three tested calcium ch", "tokenized_content": [2, 25473, 3, 1982, 1942, 4482, 1920, 4039, 1927, 5016, 4999, 13628, 1990, 25473, 17, 2719, 3939, 5532, 18, 1958, 2362, 1927, 1920, 2559, 3620, 5016, 2016, 3]}, "items": [{"id": "p_2960", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_2961", "content": "toxicity [SEP] luence of calcium channel blockers on bupivacaine-induced acute toxicity. For each of the three tested calcium channel blockers (diltiaz", "tokenized_content": [2, 5532, 3, 10908, 2055, 1927, 5016, 4999, 13628, 1990, 25473, 17, 2719, 3939, 5532, 18, 1958, 2362, 1927, 1920, 2559, 3620, 5016, 4999, 13628, 12, 4333, 11574, 1011, 3]}, "items": [{"id": "p_2961", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_2962", "content": "diltiazem [SEP] oxicity. For each of the three tested calcium channel blockers (diltiazem, verapamil and bepridil) 6 groups of mice were treated by two d", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 2833, 3610, 18, 1958, 2362, 1927, 1920, 2559, 3620, 5016, 4999, 13628, 12, 4333, 11574, 6931, 1035, 16, 23300, 1930, 1998, 2047, 13756, 1024, 13, 3]}, "items": [{"id": "p_2962", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_2963", "content": "verapamil [SEP] r each of the three tested calcium channel blockers (diltiazem, verapamil and bepridil) 6 groups of mice were treated by two different do", "tokenized_content": [2, 23300, 3, 60, 2362, 1927, 1920, 2559, 3620, 5016, 4999, 13628, 12, 4333, 11574, 6931, 1035, 16, 23300, 1930, 1998, 2047, 13756, 1024, 13, 26, 2671, 1927, 2518, 1985, 2868, 3]}, "items": [{"id": "p_2963", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_2964", "content": "bepridil [SEP] three tested calcium channel blockers (diltiazem, verapamil and bepridil) 6 groups of mice were treated by two different doses, i.e. 2 a", "tokenized_content": [2, 1998, 2047, 13756, 1024, 3, 2559, 3620, 5016, 4999, 13628, 12, 4333, 11574, 6931, 1035, 16, 23300, 1930, 1998, 2047, 13756, 1024, 13, 26, 2671, 1927, 2518, 1985, 2868, 2007, 3]}, "items": [{"id": "p_2964", "content": "Bepridil [SEP] A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation", "score": 1, "type": null, "tokenized_content": [2, 1998, 2047, 13756, 1024, 3, 43, 2815, 17, 8290, 5016, 17, 7472, 5899, 1956, 2228, 2246, 17, 16961, 1024, 2455, 18, 1920, 2838, 9300, 2228, 5846, 21742, 3]}]}
{"query": {"id": "q_2965", "content": "convulsions [SEP] ers decreased the time of latency to obtain bupivacaine-induced convulsions; this effect was less pronounced with bepridil.", "tokenized_content": [2, 4772, 19389, 3, 22877, 3261, 1920, 2367, 1927, 9393, 1942, 5649, 25473, 17, 2719, 4772, 19389, 31, 2052, 2495, 1982, 2941, 9079, 1956, 1998, 2047, 13756, 1024, 18, 3]}, "items": [{"id": "p_2965", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_2966", "content": "Selegiline [SEP] Selegiline-induced postural hypotension in Parkinson's disease: a longitud", "tokenized_content": [2, 2484, 6541, 19204, 3, 2484, 6541, 19204, 17, 2719, 17198, 16453, 1922, 10124, 11, 61, 2573, 30, 43, 6402, 3]}, "items": [{"id": "p_2966", "content": "Selegiline [SEP] A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease", "score": 1, "type": null, "tokenized_content": [2, 2484, 6541, 19204, 3, 43, 5328, 16, 14104, 4106, 1927, 2601, 44, 25368, 10488, 18, 2176, 1977, 2251, 1922, 7471, 5377, 2132, 1956, 10124, 11, 61, 2573, 3]}]}
{"query": {"id": "q_2967", "content": "postural hypotension [SEP] Selegiline-induced postural hypotension in Parkinson's disease: a longitudinal study on the effects of ", "tokenized_content": [2, 17198, 16453, 3, 2484, 6541, 19204, 17, 2719, 17198, 16453, 1922, 10124, 11, 61, 2573, 30, 43, 6676, 2161, 1990, 1920, 2564, 1927, 3]}, "items": [{"id": "p_2967", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_2968", "content": "Parkinson's disease [SEP] Selegiline-induced postural hypotension in Parkinson's disease: a longitudinal study on the effects of drug withdrawal.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 2484, 6541, 19204, 17, 2719, 17198, 16453, 1922, 10124, 11, 61, 2573, 30, 43, 6676, 2161, 1990, 1920, 2564, 1927, 2838, 9594, 18, 3]}, "items": [{"id": "p_2968", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2969", "content": "Parkinson's Disease [SEP] OBJECTIVES: The United Kingdom Parkinson's Disease Research Group (UKPDRG) trial found an increased mortality in p", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 7634, 30, 1920, 6128, 13543, 10124, 11, 61, 2573, 2659, 2210, 12, 5999, 10522, 1005, 1029, 13, 3046, 2435, 1925, 2502, 3885, 1922, 58, 3]}, "items": [{"id": "p_2969", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2970", "content": "Parkinson's disease [SEP] up (UKPDRG) trial found an increased mortality in patients with Parkinson's disease (PD) randomized to receive 10 mg selegiline per day and L-dopa ", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 2353, 12, 5999, 10522, 1005, 1029, 13, 3046, 2435, 1925, 2502, 3885, 1922, 2132, 1956, 10124, 11, 61, 2573, 12, 3203, 13, 5542, 1942, 7130, 3]}, "items": [{"id": "p_2970", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2971", "content": "PD [SEP] TIVES: The United Kingdom Parkinson's Disease Research Group (UKPDRG) trial found an increased mortality in patients with Parkinso", "tokenized_content": [2, 3203, 3, 8685, 2940, 30, 1920, 6128, 13543, 10124, 11, 61, 2573, 2659, 2210, 12, 5999, 10522, 1005, 1029, 13, 3046, 2435, 1925, 2502, 3885, 1922, 2132, 1956, 18337, 2204, 3]}, "items": [{"id": "p_2971", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_2972", "content": "selegiline [SEP] ients with Parkinson's disease (PD) randomized to receive 10 mg selegiline per day and L-dopa compared with those taking L-dopa alone. Rec", "tokenized_content": [2, 2484, 6541, 19204, 3, 10116, 4905, 1036, 1956, 10124, 11, 61, 2573, 12, 3203, 13, 5542, 1942, 7130, 2119, 2786, 2484, 6541, 19204, 2079, 3007, 1930, 54, 17, 19428, 2452, 3]}, "items": [{"id": "p_2972", "content": "Selegiline [SEP] A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease", "score": 1, "type": null, "tokenized_content": [2, 2484, 6541, 19204, 3, 43, 5328, 16, 14104, 4106, 1927, 2601, 44, 25368, 10488, 18, 2176, 1977, 2251, 1922, 7471, 5377, 2132, 1956, 10124, 11, 61, 2573, 3]}]}
{"query": {"id": "q_2973", "content": "L-dopa [SEP] disease (PD) randomized to receive 10 mg selegiline per day and L-dopa compared with those taking L-dopa alone. Recently, we found tha", "tokenized_content": [2, 54, 17, 19428, 3, 2573, 12, 3203, 13, 5542, 1942, 7130, 2119, 2786, 2484, 6541, 19204, 2079, 3007, 1930, 54, 17, 19428, 2452, 1956, 2690, 6303, 54, 17, 19428, 4298, 3]}, "items": [{"id": "p_2973", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_2974", "content": "systolic orthostatic hypotension [SEP] herapy with selegiline and L-dopa was associated with selective systolic orthostatic hypotension which was abolished by withdrawal of selegiline. This unwanted ", "tokenized_content": [2, 8541, 24343, 11494, 16453, 3, 3656, 18644, 1956, 2484, 6541, 19204, 1930, 54, 17, 19428, 1982, 2458, 1956, 5328, 8541, 24343, 11494, 16453, 2154, 1982, 10979, 2007, 9594, 1927, 2484, 3]}, "items": [{"id": "p_2974", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_2975", "content": "orthostatic hypotension [SEP] th selegiline and L-dopa was associated with selective systolic orthostatic hypotension which was abolished by withdrawal of selegiline. This unwanted ", "tokenized_content": [2, 24343, 11494, 16453, 3, 1913, 2484, 6541, 19204, 1930, 54, 17, 19428, 1982, 2458, 1956, 5328, 8541, 24343, 11494, 16453, 2154, 1982, 10979, 2007, 9594, 1927, 2484, 6541, 19204, 18, 3]}, "items": [{"id": "p_2975", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_2976", "content": "Orthostatic hypotension [SEP] esser degree of orthostatic hypotension occurred with standing. Orthostatic hypotension was ameliorated 4 days after withdrawal of selegiline and total", "tokenized_content": [2, 24343, 11494, 16453, 3, 4023, 1915, 4647, 1927, 24343, 11494, 16453, 4807, 1956, 11982, 18, 24343, 11494, 16453, 1982, 22085, 24, 3000, 2256, 9594, 1927, 2484, 6541, 19204, 1930, 2698, 3]}, "items": [{"id": "p_2976", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_2977", "content": "reduced the supine systolic and diastolic blood pressures [SEP] ontinuation of the drug. Stopping selegiline also significantly reduced the supine systolic and diastolic blood pressures consistent with a previously undescribed supine pressor action.", "tokenized_content": [2, 3028, 1920, 17740, 8541, 1930, 9395, 2877, 11704, 3, 9056, 1921, 10874, 1927, 1920, 2838, 18, 20225, 2484, 6541, 19204, 2222, 2567, 3028, 1920, 17740, 8541, 1930, 9395, 2877, 11704, 3]}, "items": [{"id": "p_2977", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_2978", "content": "amphetamine [SEP] e result of non-selective inhibition of monoamine oxidase or of amphetamine and metamphetamine are discussed.", "tokenized_content": [2, 19057, 3, 47, 3211, 1927, 2447, 17, 5328, 3523, 1927, 25368, 10488, 2014, 1927, 19057, 1930, 17432, 2102, 13271, 2032, 5601, 18, 3]}, "items": [{"id": "p_2978", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_2979", "content": "metamphetamine [SEP] selective inhibition of monoamine oxidase or of amphetamine and metamphetamine are discussed.", "tokenized_content": [2, 17432, 2102, 13271, 3, 5328, 3523, 1927, 25368, 10488, 2014, 1927, 19057, 1930, 17432, 2102, 13271, 2032, 5601, 18, 3]}, "items": [{"id": "p_2979", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_2980", "content": "capsaicin [SEP] plicit episodic memory for sensory-discriminative components of capsaicin-induced pain: immediate and delayed ratings.", "tokenized_content": [2, 19156, 3, 2123, 19753, 16843, 4525, 1958, 6893, 17, 23264, 4178, 1927, 19156, 17, 2719, 3594, 30, 8426, 1930, 7083, 10158, 18, 3]}, "items": [{"id": "p_2980", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_2981", "content": "pain [SEP] mory for sensory-discriminative components of capsaicin-induced pain: immediate and delayed ratings.", "tokenized_content": [2, 3594, 3, 2803, 1012, 1958, 6893, 17, 23264, 4178, 1927, 19156, 17, 2719, 3594, 30, 8426, 1930, 7083, 10158, 18, 3]}, "items": [{"id": "p_2981", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2982", "content": "Pain [SEP] Pain memory is thought to affect future pain sensitivity and thus co", "tokenized_content": [2, 3594, 3, 3594, 4525, 1977, 6212, 1942, 4081, 4115, 3594, 3802, 1930, 2842, 2081, 3]}, "items": [{"id": "p_2982", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2983", "content": "pain [SEP] Pain memory is thought to affect future pain sensitivity and thus contribute to clinical pain conditions. Sy", "tokenized_content": [2, 3594, 3, 3594, 4525, 1977, 6212, 1942, 4081, 4115, 3594, 3802, 1930, 2842, 4672, 1942, 2535, 3594, 2961, 18, 7930, 3]}, "items": [{"id": "p_2983", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2984", "content": "capsaicin [SEP] le volunteers received intradermal injections of three doses of capsaicin (0.05, 1 and 20 microg, separated by 15 min breaks), each given", "tokenized_content": [2, 19156, 3, 2071, 9701, 4004, 18736, 7069, 8775, 1927, 2559, 5312, 1927, 19156, 12, 20, 18, 2914, 16, 21, 1930, 2036, 12517, 16, 6239, 2007, 2461, 2360, 13065, 13, 16, 3]}, "items": [{"id": "p_2984", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_2985", "content": "pains [SEP] e hour or one day after injection. Subjects also recalled their pains one week later. Capsaicin injection reliably induced a dose-dep", "tokenized_content": [2, 3594, 1036, 3, 47, 6231, 2014, 2340, 3007, 2256, 4107, 18, 3297, 2222, 24172, 2310, 3594, 1036, 2340, 2982, 3690, 18, 19156, 4107, 13445, 2719, 43, 3253, 17, 2554, 3]}, "items": [{"id": "p_2985", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_2986", "content": "Capsaicin [SEP] r injection. Subjects also recalled their pains one week later. Capsaicin injection reliably induced a dose-dependent flare (p<0.001) wit", "tokenized_content": [2, 19156, 3, 60, 4107, 18, 3297, 2222, 24172, 2310, 3594, 1036, 2340, 2982, 3690, 18, 19156, 4107, 13445, 2719, 43, 3253, 17, 3100, 26770, 12, 58, 32, 20, 18, 3472, 3]}, "items": [{"id": "p_2986", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_2987", "content": "captopril [SEP] Reversibility of captopril-induced renal insufficiency after prolonged use in an unusual c", "tokenized_content": [2, 7502, 24863, 3, 28464, 1927, 7502, 24863, 17, 2719, 4604, 14566, 2256, 7171, 2485, 1922, 1925, 12236, 45, 3]}, "items": [{"id": "p_2987", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_2988", "content": "renal insufficiency [SEP] Reversibility of captopril-induced renal insufficiency after prolonged use in an unusual case of renovascular hyperten", "tokenized_content": [2, 4604, 14566, 3, 28464, 1927, 7502, 24863, 17, 2719, 4604, 14566, 2256, 7171, 2485, 1922, 1925, 12236, 3087, 1927, 3866, 4901, 4506, 1917, 3]}, "items": [{"id": "p_2988", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_2989", "content": "renovascular hypertension [SEP] d renal insufficiency after prolonged use in an unusual case of renovascular hypertension.", "tokenized_content": [2, 3866, 4901, 5579, 3, 46, 4604, 14566, 2256, 7171, 2485, 1922, 1925, 12236, 3087, 1927, 3866, 4901, 5579, 18, 3]}, "items": [{"id": "p_2989", "content": "Hypertension, Renovascular [SEP] Hypertension due to RENAL ARTERY OBSTRUCTION or compression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 3866, 4901, 3, 5579, 2810, 1942, 4604, 5511, 10849, 2014, 10399, 18, 3]}]}
{"query": {"id": "q_2990", "content": "hypertension [SEP] We report a case of severe hypertension with an occluded renal artery to a solitary kidney, who develop", "tokenized_content": [2, 5579, 3, 2038, 3809, 43, 3087, 1927, 4010, 5579, 1956, 1925, 22335, 4604, 5511, 1942, 43, 18992, 5245, 16, 2746, 2392, 3]}, "items": [{"id": "p_2990", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_2991", "content": "sudden deterioration of renal function [SEP] th an occluded renal artery to a solitary kidney, who developed sudden deterioration of renal function following treatment with captopril. His renal function remained", "tokenized_content": [2, 12446, 13318, 1927, 4604, 2347, 3, 1913, 1925, 22335, 4604, 5511, 1942, 43, 18992, 5245, 16, 2746, 3530, 12446, 13318, 1927, 4604, 2347, 2894, 2311, 1956, 7502, 24863, 18, 4167, 3]}, "items": [{"id": "p_2991", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_2992", "content": "captopril [SEP] sudden deterioration of renal function following treatment with captopril. His renal function remained impaired but stable during 2 years", "tokenized_content": [2, 7502, 24863, 3, 12446, 13318, 1927, 4604, 2347, 2894, 2311, 1956, 7502, 24863, 18, 4167, 4604, 2347, 5410, 5761, 2308, 4700, 2409, 22, 2739, 3]}, "items": [{"id": "p_2992", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_2993", "content": "renal failure [SEP]  of the drug. This indicates reversibility in captopril-induced renal failure even after its prolonged use and suggests that no organic damag", "tokenized_content": [2, 4604, 4574, 3, 1927, 1920, 2838, 18, 2052, 4538, 28464, 1922, 7502, 24863, 17, 2719, 4604, 4574, 3385, 2256, 2496, 7171, 2485, 1930, 4015, 1988, 2239, 6805, 3787, 2006, 3]}, "items": [{"id": "p_2993", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_2994", "content": "Liver disease [SEP] Liver disease caused by propylthiouracil.", "tokenized_content": [2, 3568, 2573, 3, 3568, 2573, 4189, 2007, 20299, 22523, 20122, 18, 3]}, "items": [{"id": "p_2994", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2995", "content": "propylthiouracil [SEP] Liver disease caused by propylthiouracil.", "tokenized_content": [2, 20299, 22523, 20122, 3, 3568, 2573, 4189, 2007, 20299, 22523, 20122, 18, 3]}, "items": [{"id": "p_2995", "content": "Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro", "score": 1, "type": null, "tokenized_content": [2, 20299, 22523, 20122, 3, 43, 15331, 16648, 10310, 30338, 12245, 5899, 18, 5062, 4626, 3940, 9280, 10401, 7042, 1920, 4271, 1927, 29423, 1930, 7042, 1920, 5009, 7309, 1927, 21980, 3]}]}
{"query": {"id": "q_2996", "content": "chronic active (aggressive) hepatitis [SEP] d light and electron microscopic observations on a patient with chronic active (aggressive) hepatitis caused by the administration of propylthiouracil. This is an ad", "tokenized_content": [2, 3724, 3500, 12, 8704, 13, 7977, 3, 46, 3696, 1930, 4995, 10372, 5184, 1990, 43, 2774, 1956, 3724, 3500, 12, 8704, 13, 7977, 4189, 2007, 1920, 4183, 1927, 20299, 22523, 3]}, "items": [{"id": "p_2996", "content": "Hepatitis, Chronic [SEP] INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and ", "score": 1, "type": null, "tokenized_content": [2, 7977, 16, 3724, 3, 4531, 1927, 1920, 3568, 1956, 8234, 12457, 4047, 1958, 26, 3221, 2014, 2253, 16, 4378, 2007, 7476, 1927, 9919, 1930, 3]}]}
{"query": {"id": "q_2997", "content": "propylthiouracil [SEP] c active (aggressive) hepatitis caused by the administration of propylthiouracil. This is an addition to the list of drugs that must be consider", "tokenized_content": [2, 20299, 22523, 20122, 3, 45, 3500, 12, 8704, 13, 7977, 4189, 2007, 1920, 4183, 1927, 20299, 22523, 20122, 18, 2052, 1977, 1925, 2459, 1942, 1920, 6069, 1927, 4195, 1988, 4902, 3]}, "items": [{"id": "p_2997", "content": "Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro", "score": 1, "type": null, "tokenized_content": [2, 20299, 22523, 20122, 3, 43, 15331, 16648, 10310, 30338, 12245, 5899, 18, 5062, 4626, 3940, 9280, 10401, 7042, 1920, 4271, 1927, 29423, 1930, 7042, 1920, 5009, 7309, 1927, 21980, 3]}]}
{"query": {"id": "q_2998", "content": "liver disease [SEP] t of drugs that must be considered in the evaluation of chronic liver disease.", "tokenized_content": [2, 3568, 2573, 3, 62, 1927, 4195, 1988, 4902, 1998, 3311, 1922, 1920, 4391, 1927, 3724, 3568, 2573, 18, 3]}, "items": [{"id": "p_2998", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_2999", "content": "Capsaicin [SEP] Capsaicin-induced muscle pain alters the excitability of the human jaw-st", "tokenized_content": [2, 19156, 3, 19156, 17, 2719, 3760, 3594, 13714, 1920, 14670, 1927, 1920, 2616, 16795, 17, 1955, 3]}, "items": [{"id": "p_2999", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_3000", "content": "muscle pain [SEP] Capsaicin-induced muscle pain alters the excitability of the human jaw-stretch reflex.", "tokenized_content": [2, 3760, 3594, 3, 19156, 17, 2719, 3760, 3594, 13714, 1920, 14670, 1927, 1920, 2616, 16795, 17, 9064, 11573, 18, 3]}, "items": [{"id": "p_3000", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_3001", "content": "temporomandibular disorders [SEP] The pathophysiology of painful temporomandibular disorders is not fully understood, but evidence suggests that muscle pain", "tokenized_content": [2, 4790, 8678, 7408, 17909, 5148, 1005, 4414, 3, 1920, 11985, 1927, 15806, 4790, 8678, 7408, 17909, 5148, 1005, 4414, 1977, 2084, 5437, 7372, 16, 2308, 3095, 4015, 1988, 3760, 3594, 3]}, "items": [{"id": "p_3001", "content": "Temporomandibular Joint Disorders [SEP] A variety of conditions affecting the anatomic and functional characteristics of the temporomandibular joint. Factors contributi", "score": 1, "type": null, "tokenized_content": [2, 4790, 8678, 7408, 17909, 5148, 1005, 6047, 4414, 3, 43, 5386, 1927, 2961, 7359, 1920, 14145, 1930, 3183, 3779, 1927, 1920, 4790, 8678, 7408, 17909, 5148, 1005, 6047, 18, 2790, 12199, 1033, 3]}]}
{"query": {"id": "q_3002", "content": "muscle pain [SEP] r disorders is not fully understood, but evidence suggests that muscle pain modulates motor function in characteristic ways. This study tes", "tokenized_content": [2, 3760, 3594, 3, 60, 4414, 1977, 2084, 5437, 7372, 16, 2308, 3095, 4015, 1988, 3760, 3594, 13112, 4842, 2347, 1922, 6293, 8079, 18, 2052, 2161, 2672, 3]}, "items": [{"id": "p_3002", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_3003", "content": "nociceptive muscle [SEP] istic ways. This study tested the hypothesis that activation of nociceptive muscle afferent fibers would be linked to an increased excitability of", "tokenized_content": [2, 19034, 3760, 3, 1977, 2002, 8079, 18, 2052, 2161, 3620, 1920, 4676, 1988, 2936, 1927, 19034, 3760, 15604, 6989, 2962, 1998, 4624, 1942, 1925, 2502, 14670, 1927, 3]}, "items": [{"id": "p_3003", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_3004", "content": "Capsaicin [SEP] ocess would be sensitive to length and velocity of the stretch. Capsaicin (10 micro g) was injected into the masseter muscle to induce pa", "tokenized_content": [2, 19156, 3, 12484, 5590, 2962, 1998, 4532, 1942, 3471, 1930, 7227, 1927, 1920, 9064, 18, 19156, 12, 2119, 2703, 49, 13, 1982, 5624, 2460, 1920, 3411, 2732, 3760, 1942, 4769, 3]}, "items": [{"id": "p_3004", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_3005", "content": "pain [SEP] The pathophysiology of painful temporomandibular disorders is not fully understood, but evi", "tokenized_content": [2, 3594, 3, 1920, 11985, 1927, 15806, 4790, 8678, 7408, 17909, 5148, 1005, 4414, 1977, 2084, 5437, 7372, 16, 2308, 2180, 1033, 3]}, "items": [{"id": "p_3005", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3006", "content": "painful muscle [SEP] icantly higher during pain, but only at faster stretches in the painful muscle. Increased sensitivity of the fusimotor system during acute mus", "tokenized_content": [2, 15806, 3760, 3, 14784, 4905, 1954, 2580, 2409, 3594, 16, 2308, 2444, 2019, 8411, 27426, 1922, 1920, 15806, 3760, 18, 2502, 3802, 1927, 1920, 10630, 18244, 2433, 2409, 3939, 3177, 3]}, "items": [{"id": "p_3006", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_3007", "content": "levodopa [SEP] Repetitive transcranial magnetic stimulation for levodopa-induced dyskinesias in Parkinson's disease.", "tokenized_content": [2, 26723, 3, 12089, 23916, 5691, 4177, 1958, 26723, 17, 2719, 3890, 26682, 1036, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_3007", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_3008", "content": "dyskinesias [SEP] petitive transcranial magnetic stimulation for levodopa-induced dyskinesias in Parkinson's disease.", "tokenized_content": [2, 3890, 26682, 1036, 3, 5889, 2470, 23916, 5691, 4177, 1958, 26723, 17, 2719, 3890, 26682, 1036, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_3008", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3009", "content": "Parkinson's disease [SEP] ranial magnetic stimulation for levodopa-induced dyskinesias in Parkinson's disease.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 2845, 2086, 5691, 4177, 1958, 26723, 17, 2719, 3890, 26682, 1036, 1922, 10124, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_3009", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_3010", "content": "dyskinesias [SEP] ic stimulation (rTMS) versus \"sham\" rTMS (placebo) on peak dose dyskinesias in patients with Parkinson's disease (PD). Ten patients with PD", "tokenized_content": [2, 3890, 26682, 1036, 3, 3996, 4177, 12, 23443, 13, 4072, 6, 8236, 6, 23443, 12, 5936, 13, 1990, 3833, 3253, 3890, 26682, 1036, 1922, 2132, 1956, 10124, 11, 61, 2573, 3]}, "items": [{"id": "p_3010", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3011", "content": "Parkinson's disease [SEP] \"sham\" rTMS (placebo) on peak dose dyskinesias in patients with Parkinson's disease (PD). Ten patients with PD and prominent dyskinesias had rTMS (", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 6, 8236, 6, 23443, 12, 5936, 13, 1990, 3833, 3253, 3890, 26682, 1036, 1922, 2132, 1956, 10124, 11, 61, 2573, 12, 3203, 13, 18, 5656, 3]}, "items": [{"id": "p_3011", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_3012", "content": "PD [SEP]  on peak dose dyskinesias in patients with Parkinson's disease (PD). Ten patients with PD and prominent dyskinesias had rTMS (1,80", "tokenized_content": [2, 3203, 3, 1990, 3833, 3253, 3890, 26682, 1036, 1922, 2132, 1956, 10124, 11, 61, 2573, 12, 3203, 13, 18, 5656, 2132, 1956, 3203, 1930, 8753, 3890, 26682, 1036, 2430, 23443, 3]}, "items": [{"id": "p_3012", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_3013", "content": "dyskinesia [SEP] ic stimulation (rTMS) versus \"sham\" rTMS (placebo) on peak dose dyskinesias in patients with Parkinson's disease (PD). Ten patients with P", "tokenized_content": [2, 3890, 26682, 3, 3996, 4177, 12, 23443, 13, 4072, 6, 8236, 6, 23443, 12, 5936, 13, 1990, 3833, 3253, 3890, 26682, 1036, 1922, 2132, 1956, 10124, 11, 61, 2573, 12, 3]}, "items": [{"id": "p_3013", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3014", "content": "dystonia [SEP] ty following real rTMS but not placebo. The major effect was on dystonia subscore. Similarly, in patient diaries, although both treatmen", "tokenized_content": [2, 23357, 3, 6227, 2894, 4105, 23443, 2308, 2084, 5936, 18, 1920, 3044, 2495, 1982, 1990, 23357, 2468, 26231, 18, 4852, 16, 1922, 2774, 25141, 25921, 16, 2876, 2321, 2297, 19047, 3]}, "items": [{"id": "p_3014", "content": "Dystonia [SEP] An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often aff", "score": 1, "type": null, "tokenized_content": [2, 23357, 3, 1925, 14204, 2014, 17858, 2810, 1942, 1920, 2081, 17, 8332, 1927, 9849, 1930, 8151, 7848, 1922, 2340, 3031, 1927, 1920, 3362, 18, 2176, 2501, 3868, 2633, 3]}]}
{"query": {"id": "q_3015", "content": "Disulfiram [SEP] Disulfiram-like syndrome after hydrogen cyanamide professional skin exposu", "tokenized_content": [2, 10993, 11979, 1035, 3, 10993, 11979, 1035, 17, 3189, 4741, 2256, 6201, 10208, 5482, 8578, 4407, 2938, 1032, 3]}, "items": [{"id": "p_3015", "content": "Disulfiram [SEP] A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly", "score": 1, "type": null, "tokenized_content": [2, 10993, 11979, 1035, 3, 43, 17742, 2010, 10533, 2251, 1966, 1925, 4284, 10641, 2825, 1031, 18, 2176, 1977, 43, 4322, 18037, 10605, 7311, 2469, 5254, 4298, 16, 2308, 7686, 3]}]}
{"query": {"id": "q_3016", "content": "hydrogen cyanamide [SEP] Disulfiram-like syndrome after hydrogen cyanamide professional skin exposure: two case reports in France.", "tokenized_content": [2, 6201, 10208, 5482, 3, 10993, 11979, 1035, 17, 3189, 4741, 2256, 6201, 10208, 5482, 8578, 4407, 3395, 30, 2288, 3087, 4710, 1922, 10707, 18, 3]}, "items": [{"id": "p_3016", "content": "Cyanamide [SEP] A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the ca", "score": 1, "type": null, "tokenized_content": [2, 10208, 5482, 3, 43, 26164, 3547, 2154, 2258, 2252, 2251, 1966, 43, 26179, 16, 2480, 18676, 4905, 1930, 1922, 3086, 16140, 4028, 18, 2176, 3868, 5110, 1966, 1920, 2332, 3]}]}
{"query": {"id": "q_3017", "content": "Hydrogen cyanamide [SEP] Hydrogen cyanamide is a plant growth regulator used in agriculture to induce bud b", "tokenized_content": [2, 6201, 10208, 5482, 3, 6201, 10208, 5482, 1977, 43, 4496, 2905, 7888, 2251, 1922, 15457, 1942, 4769, 8344, 44, 3]}, "items": [{"id": "p_3017", "content": "Cyanamide [SEP] A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the ca", "score": 1, "type": null, "tokenized_content": [2, 10208, 5482, 3, 43, 26164, 3547, 2154, 2258, 2252, 2251, 1966, 43, 26179, 16, 2480, 18676, 4905, 1930, 1922, 3086, 16140, 4028, 18, 2176, 3868, 5110, 1966, 1920, 2332, 3]}]}
{"query": {"id": "q_3018", "content": "aldehyde [SEP] esult in percutaneous absorption of the substance that inhibits aldehyde dehydrogenase and can induce acetaldehyde syndrome in case of a", "tokenized_content": [2, 18727, 3, 2376, 2402, 1922, 12826, 6726, 1927, 1920, 7311, 1988, 7042, 18727, 9294, 1930, 2112, 4769, 29141, 4741, 1922, 3087, 1927, 43, 3]}, "items": [{"id": "p_3018", "content": "Acetaldehyde [SEP] A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the m", "score": 1, "type": null, "tokenized_content": [2, 29141, 3, 43, 29500, 16, 2300, 24788, 7272, 5875, 2251, 1922, 1920, 24021, 1927, 13069, 2687, 16, 5294, 24694, 16, 1930, 26703, 1036, 18, 2176, 1977, 2222, 1925, 6129, 1922, 1920, 55, 3]}]}
{"query": {"id": "q_3019", "content": "acetaldehyde [SEP] e substance that inhibits aldehyde dehydrogenase and can induce acetaldehyde syndrome in case of alcohol use. The purpose of this report is ", "tokenized_content": [2, 29141, 3, 47, 7311, 1988, 7042, 18727, 9294, 1930, 2112, 4769, 29141, 4741, 1922, 3087, 1927, 4284, 2485, 18, 1920, 5120, 1927, 2052, 3809, 1977, 3]}, "items": [{"id": "p_3019", "content": "Acetaldehyde [SEP] A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the m", "score": 1, "type": null, "tokenized_content": [2, 29141, 3, 43, 29500, 16, 2300, 24788, 7272, 5875, 2251, 1922, 1920, 24021, 1927, 13069, 2687, 16, 5294, 24694, 16, 1930, 26703, 1036, 18, 2176, 1977, 2222, 1925, 6129, 1922, 1920, 55, 3]}]}
{"query": {"id": "q_3020", "content": "alcohol [SEP] e dehydrogenase and can induce acetaldehyde syndrome in case of alcohol use. The purpose of this report is to describe two cases of a d", "tokenized_content": [2, 4284, 3, 47, 9294, 1930, 2112, 4769, 29141, 4741, 1922, 3087, 1927, 4284, 2485, 18, 1920, 5120, 1927, 2052, 3809, 1977, 1942, 5993, 2288, 2919, 1927, 43, 46, 3]}, "items": [{"id": "p_3020", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_3021", "content": "disulfiram [SEP] l use. The purpose of this report is to describe two cases of a disulfiram-like syndrome following occupational exposure to hydrogen cyana", "tokenized_content": [2, 10993, 11979, 1035, 3, 54, 2485, 18, 1920, 5120, 1927, 2052, 3809, 1977, 1942, 5993, 2288, 2919, 1927, 43, 10993, 11979, 1035, 17, 3189, 4741, 2894, 10485, 3395, 1942, 6201, 3]}, "items": [{"id": "p_3021", "content": "Disulfiram [SEP] A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly", "score": 1, "type": null, "tokenized_content": [2, 10993, 11979, 1035, 3, 43, 17742, 2010, 10533, 2251, 1966, 1925, 4284, 10641, 2825, 1031, 18, 2176, 1977, 43, 4322, 18037, 10605, 7311, 2469, 5254, 4298, 16, 2308, 7686, 3]}]}
{"query": {"id": "q_3022", "content": "hydrogen cyanamide [SEP] f a disulfiram-like syndrome following occupational exposure to hydrogen cyanamide. The first case involved a 59-year-old man who used Dormex, whi", "tokenized_content": [2, 6201, 10208, 5482, 3, 48, 43, 10993, 11979, 1035, 17, 3189, 4741, 2894, 10485, 3395, 1942, 6201, 10208, 5482, 18, 1920, 2561, 3087, 3286, 43, 4777, 17, 2476, 17, 4156, 3]}, "items": [{"id": "p_3022", "content": "Cyanamide [SEP] A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the ca", "score": 1, "type": null, "tokenized_content": [2, 10208, 5482, 3, 43, 26164, 3547, 2154, 2258, 2252, 2251, 1966, 43, 26179, 16, 2480, 18676, 4905, 1930, 1922, 3086, 16140, 4028, 18, 2176, 3868, 5110, 1966, 1920, 2332, 3]}]}
{"query": {"id": "q_3023", "content": "Dormex [SEP] n cyanamide. The first case involved a 59-year-old man who used Dormex, which contains hydrogen cyanamide, without protection after co", "tokenized_content": [2, 17730, 2783, 3, 56, 10208, 5482, 18, 1920, 2561, 3087, 3286, 43, 4777, 17, 2476, 17, 4156, 2323, 2746, 2251, 17730, 2783, 16, 2154, 5461, 6201, 10208, 5482, 16, 2979, 3]}, "items": [{"id": "p_3023", "content": "Cyanamide [SEP] A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the ca", "score": 1, "type": null, "tokenized_content": [2, 10208, 5482, 3, 43, 26164, 3547, 2154, 2258, 2252, 2251, 1966, 43, 26179, 16, 2480, 18676, 4905, 1930, 1922, 3086, 16140, 4028, 18, 2176, 3868, 5110, 1966, 1920, 2332, 3]}]}
{"query": {"id": "q_3024", "content": "flushing of the face [SEP]  hour after the ingestion of alcohol, he developed malaise with flushing of the face, tachycardia, and dyspnea. Manifestations regressed spontaneous", "tokenized_content": [2, 2848, 6150, 1941, 1927, 1920, 6171, 3, 6231, 2256, 1920, 14195, 1927, 4284, 16, 2234, 3530, 3054, 5504, 4127, 1956, 2848, 6150, 1941, 1927, 1920, 6171, 16, 17397, 16, 1930, 3]}, "items": [{"id": "p_3024", "content": "Flushing [SEP] A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 6150, 1941, 3, 43, 6809, 2312, 5233, 1941, 1927, 1920, 6171, 1988, 2278, 1998, 2810, 1942, 9087, 16, 4908, 4195, 16, 28187, 16, 3071, 16, 2014, 43, 2573, 2585, 18, 3]}]}
{"query": {"id": "q_3025", "content": "tachycardia [SEP] ion of alcohol, he developed malaise with flushing of the face, tachycardia, and dyspnea. Manifestations regressed spontaneously under surv", "tokenized_content": [2, 17397, 3, 4755, 1927, 4284, 16, 2234, 3530, 3054, 5504, 4127, 1956, 2848, 6150, 1941, 1927, 1920, 6171, 16, 17397, 16, 1930, 18461, 18, 10952, 26832, 12753, 2441, 3098, 3]}, "items": [{"id": "p_3025", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_3026", "content": "dyspnea [SEP] e developed malaise with flushing of the face, tachycardia, and dyspnea. Manifestations regressed spontaneously under surveillance in t", "tokenized_content": [2, 18461, 3, 47, 3530, 3054, 5504, 4127, 1956, 2848, 6150, 1941, 1927, 1920, 6171, 16, 17397, 16, 1930, 18461, 18, 10952, 26832, 12753, 2441, 7889, 1922, 62, 3]}, "items": [{"id": "p_3026", "content": "Dyspnea [SEP] Difficult or labored breathing.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18461, 3, 4571, 2014, 3876, 1919, 11995, 18, 3]}]}
{"query": {"id": "q_3027", "content": "flushing [SEP]  hour after the ingestion of alcohol, he developed malaise with flushing of the face, tachycardia, and dyspnea. Manifestations regressed", "tokenized_content": [2, 2848, 6150, 1941, 3, 6231, 2256, 1920, 14195, 1927, 4284, 16, 2234, 3530, 3054, 5504, 4127, 1956, 2848, 6150, 1941, 1927, 1920, 6171, 16, 17397, 16, 1930, 18461, 18, 10952, 3]}, "items": [{"id": "p_3027", "content": "Flushing [SEP] A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2848, 6150, 1941, 3, 43, 6809, 2312, 5233, 1941, 1927, 1920, 6171, 1988, 2278, 1998, 2810, 1942, 9087, 16, 4908, 4195, 16, 28187, 16, 3071, 16, 2014, 43, 2573, 2585, 18, 3]}]}
{"query": {"id": "q_3028", "content": "arterial hypotension [SEP] eloped disulfiram-like syndrome with flushing, tachycardia, and arterial hypotension after consuming three glasses of wine. The patient recovered sp", "tokenized_content": [2, 6624, 16453, 3, 2349, 4907, 1007, 10993, 11979, 1035, 17, 3189, 4741, 1956, 2848, 6150, 1941, 16, 17397, 16, 1930, 6624, 16453, 2256, 12359, 2559, 25967, 1927, 19201, 18, 1920, 3]}, "items": [{"id": "p_3028", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3029", "content": "trimipramine [SEP] Repeated trimipramine induces dopamine D2/D3 and alpha1-adrenergic up-regulation.", "tokenized_content": [2, 7103, 27085, 3, 5116, 7103, 27085, 6387, 7964, 8631, 19, 11319, 1930, 4595, 1009, 17, 13672, 2353, 17, 3640, 18, 3]}, "items": [{"id": "p_3029", "content": "Trimipramine [SEP] Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7103, 27085, 3, 12258, 13153, 14183, 2551, 1942, 2042, 27085, 16, 2308, 1956, 2253, 12946, 25879, 8547, 1935, 1930, 28514, 3879, 18, 3]}]}
{"query": {"id": "q_3030", "content": "dopamine [SEP] Repeated trimipramine induces dopamine D2/D3 and alpha1-adrenergic up-regulation.", "tokenized_content": [2, 7964, 3, 5116, 7103, 27085, 6387, 7964, 8631, 19, 11319, 1930, 4595, 1009, 17, 13672, 2353, 17, 3640, 18, 3]}, "items": [{"id": "p_3030", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3031", "content": "Trimipramine [SEP] Trimipramine (TRI), which shows a clinical antidepressant activity, is chemi", "tokenized_content": [2, 7103, 27085, 3, 7103, 27085, 12, 5083, 13, 16, 2154, 3661, 43, 2535, 14183, 2455, 16, 1977, 2975, 1033, 3]}, "items": [{"id": "p_3031", "content": "Trimipramine [SEP] Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7103, 27085, 3, 12258, 13153, 14183, 2551, 1942, 2042, 27085, 16, 2308, 1956, 2253, 12946, 25879, 8547, 1935, 1930, 28514, 3879, 18, 3]}]}
{"query": {"id": "q_3032", "content": "TRI [SEP] Trimipramine (TRI), which shows a clinical antidepressant activity, is chemically", "tokenized_content": [2, 5083, 3, 7103, 27085, 12, 5083, 13, 16, 2154, 3661, 43, 2535, 14183, 2455, 16, 1977, 13944, 3]}, "items": [{"id": "p_3032", "content": "Trimipramine [SEP] Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7103, 27085, 3, 12258, 13153, 14183, 2551, 1942, 2042, 27085, 16, 2308, 1956, 2253, 12946, 25879, 8547, 1935, 1930, 28514, 3879, 18, 3]}]}
{"query": {"id": "q_3033", "content": "antidepressant [SEP] Trimipramine (TRI), which shows a clinical antidepressant activity, is chemically related to imipramine but does not inhi", "tokenized_content": [2, 14183, 3, 7103, 27085, 12, 5083, 13, 16, 2154, 3661, 43, 2535, 14183, 2455, 16, 1977, 13944, 2712, 1942, 2042, 27085, 2308, 3731, 2084, 11035, 1033, 3]}, "items": [{"id": "p_3033", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_3034", "content": "imipramine [SEP] Trimipramine (TRI), which shows a clinical antidepressant activity, is chemi", "tokenized_content": [2, 2042, 27085, 3, 7103, 27085, 12, 5083, 13, 16, 2154, 3661, 43, 2535, 14183, 2455, 16, 1977, 2975, 1033, 3]}, "items": [{"id": "p_3034", "content": "Imipramine [SEP] The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-defici", "score": 1, "type": null, "tokenized_content": [2, 2042, 27085, 3, 1920, 29183, 12258, 13153, 14183, 18, 2176, 2258, 2252, 2251, 1922, 3044, 4621, 16, 10612, 30338, 6026, 16, 10275, 4621, 16, 4976, 17, 6428, 1033, 3]}]}
{"query": {"id": "q_3035", "content": "noradrenaline [SEP] ally related to imipramine but does not inhibit the reuptake of noradrenaline and 5-hydroxytryptamine, nor does it induce beta-adrenergic dow", "tokenized_content": [2, 22636, 3, 2136, 1012, 2712, 1942, 2042, 27085, 2308, 3731, 2084, 2875, 1920, 22957, 1927, 22636, 1930, 25, 17, 8275, 30298, 3812, 16, 3990, 3731, 2176, 4769, 4666, 17, 13672, 3]}, "items": [{"id": "p_3035", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_3036", "content": "5-hydroxytryptamine [SEP] ipramine but does not inhibit the reuptake of noradrenaline and 5-hydroxytryptamine, nor does it induce beta-adrenergic down-regulation. The mechan", "tokenized_content": [2, 25, 17, 8275, 30298, 3812, 3, 27194, 3812, 2308, 3731, 2084, 2875, 1920, 22957, 1927, 22636, 1930, 25, 17, 8275, 30298, 3812, 16, 3990, 3731, 2176, 4769, 4666, 17, 13672, 3]}, "items": [{"id": "p_3036", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3037", "content": "antidepressants [SEP] 1-adrenergic systems, demonstrated by us previously for various antidepressants. TRI was given to male Wistar rats and male Albino Swiss mice p", "tokenized_content": [2, 17722, 3, 21, 17, 13672, 3771, 16, 3161, 2007, 2022, 3024, 1958, 3425, 17722, 18, 5083, 1982, 3258, 1942, 4005, 15668, 3615, 1930, 4005, 28734, 15412, 2518, 58, 3]}, "items": [{"id": "p_3037", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_3038", "content": "reserpine [SEP] n the acute experiment TRI (given i.p.) does not antagonize the reserpine hypothermia in mice and does not potentiate the 5-hydroxytrypto", "tokenized_content": [2, 1995, 1915, 12184, 3, 56, 1920, 3939, 3859, 5083, 12, 3258, 51, 18, 58, 18, 13, 3731, 2084, 28104, 1920, 1995, 1915, 12184, 18750, 1922, 2518, 1930, 3731, 2084, 23350, 3]}, "items": [{"id": "p_3038", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_3039", "content": "hypothermia [SEP] e experiment TRI (given i.p.) does not antagonize the reserpine hypothermia in mice and does not potentiate the 5-hydroxytryptophan head tw", "tokenized_content": [2, 18750, 3, 47, 3859, 5083, 12, 3258, 51, 18, 58, 18, 13, 3731, 2084, 28104, 1920, 1995, 1915, 12184, 18750, 1922, 2518, 1930, 3731, 2084, 23350, 1920, 25, 17, 8275, 3]}, "items": [{"id": "p_3039", "content": "Hypothermia [SEP] Lower than normal body temperature, especially in warm-blooded animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18750, 3, 2826, 2254, 2791, 3362, 3449, 16, 4369, 1922, 10142, 17, 2877, 1919, 3555, 18, 3]}]}
{"query": {"id": "q_3040", "content": "5-hydroxytryptophan [SEP] e the reserpine hypothermia in mice and does not potentiate the 5-hydroxytryptophan head twitches in rats. TRI given repeatedly to rats increases t", "tokenized_content": [2, 25, 17, 8275, 30298, 2688, 1928, 3, 47, 1920, 1995, 1915, 12184, 18750, 1922, 2518, 1930, 3731, 2084, 23350, 1920, 25, 17, 8275, 30298, 2688, 1928, 4469, 21596, 1918, 1922, 3]}, "items": [{"id": "p_3040", "content": "5-Hydroxytryptophan [SEP] The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.\n   ", "score": 1, "type": null, "tokenized_content": [2, 25, 17, 8275, 30298, 2688, 1928, 3, 1920, 8426, 7897, 1922, 1920, 8132, 1927, 11153, 2037, 13489, 18, 2176, 1977, 2251, 1966, 1925, 29132, 1930, 14183, 18, 3]}]}
{"query": {"id": "q_3041", "content": "hyperactivity [SEP] s in rats. TRI given repeatedly to rats increases the locomotor hyperactivity induced by d-amphetamine, quinpirole and (+)-7-hydroxy-dipropyl", "tokenized_content": [2, 15534, 3, 61, 1922, 3615, 18, 5083, 3258, 14959, 1942, 3615, 4041, 1920, 13594, 15534, 2719, 2007, 46, 17, 19057, 16, 9012, 10984, 15828, 1930, 12, 15, 13, 17, 27, 3]}, "items": [{"id": "p_3041", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_3042", "content": "d-amphetamine [SEP] atedly to rats increases the locomotor hyperactivity induced by d-amphetamine, quinpirole and (+)-7-hydroxy-dipropyloaminotetralin (dopamine ", "tokenized_content": [2, 46, 17, 19057, 3, 30280, 21541, 1012, 1942, 3615, 4041, 1920, 13594, 15534, 2719, 2007, 46, 17, 19057, 16, 9012, 10984, 15828, 1930, 12, 15, 13, 17, 27, 17, 8275, 3]}, "items": [{"id": "p_3042", "content": "Dextroamphetamine [SEP] The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatmen", "score": 1, "type": null, "tokenized_content": [2, 20256, 1931, 18996, 3, 1920, 46, 17, 2386, 1927, 19057, 18, 2176, 1977, 43, 4101, 7580, 2433, 24252, 1930, 43, 26638, 1947, 21870, 18, 2176, 2258, 2222, 2252, 2251, 1922, 1920, 2297, 19047, 3]}]}
{"query": {"id": "q_3043", "content": "quinpirole [SEP] increases the locomotor hyperactivity induced by d-amphetamine, quinpirole and (+)-7-hydroxy-dipropyloaminotetralin (dopamine D2 and D3 ef", "tokenized_content": [2, 9012, 10984, 15828, 3, 4041, 1920, 13594, 15534, 2719, 2007, 46, 17, 19057, 16, 9012, 10984, 15828, 1930, 12, 15, 13, 17, 27, 17, 8275, 17, 9137, 12384, 6952, 8547, 3]}, "items": [{"id": "p_3043", "content": "Quinpirole [SEP] A dopamine D2/D3 receptor agonist.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9012, 10984, 15828, 3, 43, 7964, 8631, 19, 11319, 3148, 7829, 18, 3]}]}
{"query": {"id": "q_3044", "content": "dopamine [SEP] TRI given repeatedly was able to induce adaptive changes in the dopaminergic and alpha1-adrenergic systems, demonstrated by us previousl", "tokenized_content": [2, 7964, 3, 5083, 3258, 14959, 1982, 4236, 1942, 4769, 7617, 2840, 1922, 1920, 12214, 1930, 4595, 1009, 17, 13672, 3771, 16, 3161, 2007, 2022, 2555, 1024, 3]}, "items": [{"id": "p_3044", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3045", "content": "apomorphine [SEP] 2 and D3 effects). The stereotypies induced by d-amphetamine or apomorphine are not potentiated by TRI. It increases the behaviour stimulat", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 22, 1930, 11319, 2564, 13, 18, 1920, 18028, 2085, 2062, 2719, 2007, 46, 17, 19057, 2014, 11466, 12492, 11119, 7969, 2912, 2032, 2084, 20419, 3]}, "items": [{"id": "p_3045", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_3046", "content": "phenylephrine [SEP] tiated by TRI. It increases the behaviour stimulation evoked by phenylephrine (given intraventricularly) in rats, evaluated in the open field", "tokenized_content": [2, 27053, 3, 22093, 2013, 2007, 5083, 18, 2176, 4041, 1920, 6270, 4177, 8782, 2007, 27053, 12, 3258, 29510, 1954, 13, 1922, 3615, 16, 3747, 1922, 1920, 4437, 3559, 3]}, "items": [{"id": "p_3046", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_3047", "content": "aggressiveness [SEP] larly) in rats, evaluated in the open field test as well as the aggressiveness evoked by clonidine in mice, both these effects being mediated ", "tokenized_content": [2, 23161, 3, 6590, 1954, 13, 1922, 3615, 16, 3747, 1922, 1920, 4437, 3559, 2648, 1966, 2486, 1966, 1920, 23161, 8782, 2007, 26596, 1922, 2518, 16, 2321, 2144, 2564, 3301, 3434, 3]}, "items": [{"id": "p_3047", "content": "Personality Disorders [SEP] A major deviation from normal patterns of behavior.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10111, 4414, 3, 43, 3044, 6015, 2037, 2791, 4147, 1927, 3379, 18, 3]}]}
{"query": {"id": "q_3048", "content": "clonidine [SEP]  in the open field test as well as the aggressiveness evoked by clonidine in mice, both these effects being mediated by an alpha1-adrener", "tokenized_content": [2, 26596, 3, 1922, 1920, 4437, 3559, 2648, 1966, 2486, 1966, 1920, 23161, 8782, 2007, 26596, 1922, 2518, 16, 2321, 2144, 2564, 3301, 3434, 2007, 1925, 4595, 1009, 17, 7206, 1915, 3]}, "items": [{"id": "p_3048", "content": "Clonidine [SEP] An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonl", "score": 1, "type": null, "tokenized_content": [2, 26596, 3, 1925, 20697, 10457, 2053, 26638, 6586, 5899, 1988, 11803, 4595, 17, 22, 13672, 4086, 1930, 4101, 20697, 10457, 2053, 4086, 18, 2176, 1977, 3059, 1024, 3]}]}
{"query": {"id": "q_3049", "content": "Ranitidine [SEP] Ranitidine-induced acute interstitial nephritis in a cadaveric renal allog", "tokenized_content": [2, 2845, 2078, 27099, 3, 2845, 2078, 27099, 17, 2719, 3939, 11584, 25064, 1922, 43, 28670, 4604, 14238, 1029, 3]}, "items": [{"id": "p_3049", "content": "Ranitidine [SEP] A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastroin", "score": 1, "type": null, "tokenized_content": [2, 2845, 2078, 27099, 3, 43, 2447, 17, 16045, 14580, 1927, 2690, 14622, 4086, 1988, 8265, 6319, 5512, 12, 4881, 4086, 13, 18, 2176, 1977, 2251, 1942, 2297, 6858, 1921, 3]}]}
{"query": {"id": "q_3050", "content": "interstitial nephritis [SEP] Ranitidine-induced acute interstitial nephritis in a cadaveric renal allograft.", "tokenized_content": [2, 11584, 25064, 3, 2845, 2078, 27099, 17, 2719, 3939, 11584, 25064, 1922, 43, 28670, 4604, 15941, 18, 3]}, "items": [{"id": "p_3050", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_3051", "content": "Ranitidine [SEP] Ranitidine frequently is used for preventing peptic ulceration after renal", "tokenized_content": [2, 2845, 2078, 27099, 3, 2845, 2078, 27099, 5467, 1977, 2251, 1958, 8444, 29488, 23509, 2256, 4604, 3]}, "items": [{"id": "p_3051", "content": "Ranitidine [SEP] A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastroin", "score": 1, "type": null, "tokenized_content": [2, 2845, 2078, 27099, 3, 43, 2447, 17, 16045, 14580, 1927, 2690, 14622, 4086, 1988, 8265, 6319, 5512, 12, 4881, 4086, 13, 18, 2176, 1977, 2251, 1942, 2297, 6858, 1921, 3]}]}
{"query": {"id": "q_3052", "content": "interstitial nephritis [SEP] antation. This drug occasionally has been associated with acute interstitial nephritis in native kidneys. There are no similar reports with renal tran", "tokenized_content": [2, 11584, 25064, 3, 4942, 1943, 18, 2052, 2838, 14647, 2258, 2252, 2458, 1956, 3939, 11584, 25064, 1922, 6196, 11770, 18, 2276, 2032, 2239, 2551, 4710, 1956, 4604, 29808, 3]}, "items": [{"id": "p_3052", "content": "Nephritis, Interstitial [SEP] Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES an", "score": 1, "type": null, "tokenized_content": [2, 25064, 16, 11584, 3, 4531, 1927, 1920, 11584, 2960, 1927, 1920, 5245, 18, 2052, 2576, 1977, 4933, 2251, 1958, 3065, 4531, 1927, 5245, 14876, 1925, 3]}]}
{"query": {"id": "q_3053", "content": "ranitidine [SEP] similar reports with renal transplantation. We report a case of ranitidine-induced acute interstitial nephritis in a recipient of a cadave", "tokenized_content": [2, 2845, 2078, 27099, 3, 2551, 4710, 1956, 4604, 6530, 18, 2038, 3809, 43, 3087, 1927, 2845, 2078, 27099, 17, 2719, 3939, 11584, 25064, 1922, 43, 10664, 1927, 43, 5643, 7921, 3]}, "items": [{"id": "p_3053", "content": "Ranitidine [SEP] A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastroin", "score": 1, "type": null, "tokenized_content": [2, 2845, 2078, 27099, 3, 43, 2447, 17, 16045, 14580, 1927, 2690, 14622, 4086, 1988, 8265, 6319, 5512, 12, 4881, 4086, 13, 18, 2176, 1977, 2251, 1942, 2297, 6858, 1921, 3]}]}
{"query": {"id": "q_3054", "content": "doxorubicin [SEP] Late, late doxorubicin cardiotoxicity.", "tokenized_content": [2, 12377, 3, 5058, 16, 5058, 12377, 30490, 18, 3]}, "items": [{"id": "p_3054", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3055", "content": "cardiotoxicity [SEP] Late, late doxorubicin cardiotoxicity.", "tokenized_content": [2, 30490, 3, 5058, 16, 5058, 12377, 30490, 18, 3]}, "items": [{"id": "p_3055", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3056", "content": "Cardiac toxicity [SEP] Cardiac toxicity is a major complication which limits the use of adriamycin as a", "tokenized_content": [2, 4435, 5532, 3, 4435, 5532, 1977, 43, 3044, 9388, 2154, 8183, 1920, 2485, 1927, 25622, 7898, 1966, 43, 3]}, "items": [{"id": "p_3056", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3057", "content": "adriamycin [SEP] ardiac toxicity is a major complication which limits the use of adriamycin as a chemotherapeutic agent. Cardiomyopathy is frequent when th", "tokenized_content": [2, 25622, 7898, 3, 2245, 7408, 1948, 5532, 1977, 43, 3044, 9388, 2154, 8183, 1920, 2485, 1927, 25622, 7898, 1966, 43, 14124, 5899, 18, 14141, 1977, 6439, 2469, 1913, 3]}, "items": [{"id": "p_3057", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3058", "content": "Cardiomyopathy [SEP] which limits the use of adriamycin as a chemotherapeutic agent. Cardiomyopathy is frequent when the total dose exceeds 600 mg/m2 and occurs wi", "tokenized_content": [2, 14141, 3, 2154, 8183, 1920, 2485, 1927, 25622, 7898, 1966, 43, 14124, 5899, 18, 14141, 1977, 6439, 2469, 1920, 2698, 3253, 18216, 8333, 2786, 19, 6056, 1930, 5110, 11980, 3]}, "items": [{"id": "p_3058", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3059", "content": "cardiomyopathy [SEP] ion of therapy. A patient is reported who developed progressive cardiomyopathy two and one-half years after receiving 580 mg/m2 which apparent", "tokenized_content": [2, 14141, 3, 4755, 1927, 3181, 18, 43, 2774, 1977, 2568, 2746, 3530, 7529, 14141, 2288, 1930, 2340, 17, 4768, 2739, 2256, 5962, 25195, 2786, 19, 6056, 2154, 6273, 3]}, "items": [{"id": "p_3059", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3060", "content": "cardiotoxicity [SEP] fter receiving 580 mg/m2 which apparently represents late, late cardiotoxicity.", "tokenized_content": [2, 30490, 3, 8916, 1915, 5962, 25195, 2786, 19, 6056, 2154, 10535, 4972, 5058, 16, 5058, 30490, 18, 3]}, "items": [{"id": "p_3060", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3061", "content": "Acetazolamide [SEP] Acetazolamide-induced nephrolithiasis: implications for treatment of neuromus", "tokenized_content": [2, 4118, 21585, 2261, 3, 4118, 21585, 2261, 17, 2719, 7737, 2226, 29016, 30, 7020, 1958, 2311, 1927, 11408, 1957, 3]}, "items": [{"id": "p_3061", "content": "Acetazolamide [SEP] One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an", "score": 1, "type": null, "tokenized_content": [2, 4118, 21585, 2261, 3, 2340, 1927, 1920, 5056, 1935, 22018, 2051, 4472, 1988, 1977, 8929, 3655, 3316, 3905, 10060, 18, 2176, 1977, 8929, 4707, 2222, 1966, 1925, 3]}]}
{"query": {"id": "q_3062", "content": "nephrolithiasis [SEP] Acetazolamide-induced nephrolithiasis: implications for treatment of neuromuscular disorders.", "tokenized_content": [2, 7737, 2226, 29016, 3, 4118, 21585, 2261, 17, 2719, 7737, 2226, 29016, 30, 7020, 1958, 2311, 1927, 15829, 4414, 18, 3]}, "items": [{"id": "p_3062", "content": "Nephrolithiasis [SEP] Formation of stones in the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7737, 2226, 29016, 3, 3337, 1927, 18183, 1922, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_3063", "content": "neuromuscular disorders [SEP] zolamide-induced nephrolithiasis: implications for treatment of neuromuscular disorders.", "tokenized_content": [2, 15829, 4414, 3, 21483, 5482, 17, 2719, 7737, 2226, 29016, 30, 7020, 1958, 2311, 1927, 15829, 4414, 18, 3]}, "items": [{"id": "p_3063", "content": "Neuromuscular Diseases [SEP] A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manif", "score": 1, "type": null, "tokenized_content": [2, 15829, 3902, 3, 43, 3335, 2576, 17527, 2826, 4842, 7428, 2573, 31, 5009, 7580, 2433, 3902, 31, 1930, 4908, 12330, 3902, 18, 6747, 3]}]}
{"query": {"id": "q_3064", "content": "nephrolithiasis [SEP] Carbonic anhydrase inhibitors can cause nephrolithiasis. We studied 20 patients receiving long-term carbonic anhydrase ", "tokenized_content": [2, 7737, 2226, 29016, 3, 5056, 1935, 22018, 2051, 4472, 2112, 3936, 7737, 2226, 29016, 18, 2038, 3942, 2036, 2132, 5962, 2815, 17, 2576, 5056, 1935, 22018, 2051, 3]}, "items": [{"id": "p_3064", "content": "Nephrolithiasis [SEP] Formation of stones in the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7737, 2226, 29016, 3, 3337, 1927, 18183, 1922, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_3065", "content": "paralysis [SEP] g long-term carbonic anhydrase inhibitor treatment for periodic paralysis and myotonia. Three patients on acetazolamide (15%) developed r", "tokenized_content": [2, 18973, 3, 49, 2815, 17, 2576, 5056, 1935, 22018, 2051, 4106, 2311, 1958, 12922, 18973, 1930, 15924, 5405, 2126, 18, 2559, 2132, 1990, 4118, 21585, 2261, 12, 2461, 9, 13, 3]}, "items": [{"id": "p_3065", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_3066", "content": "myotonia [SEP] rbonic anhydrase inhibitor treatment for periodic paralysis and myotonia. Three patients on acetazolamide (15%) developed renal calculi.", "tokenized_content": [2, 15924, 5405, 2126, 3, 6160, 3490, 22018, 2051, 4106, 2311, 1958, 12922, 18973, 1930, 15924, 5405, 2126, 18, 2559, 2132, 1990, 4118, 21585, 2261, 12, 2461, 9, 13, 3530, 4604, 3]}, "items": [{"id": "p_3066", "content": "Myotonia [SEP] Prolonged failure of muscle relaxation after contraction. This may occur after voluntary contractions, muscle percussion, or ele", "score": 1, "type": null, "tokenized_content": [2, 15924, 5405, 2126, 3, 7171, 4574, 1927, 3760, 9157, 2256, 8332, 18, 2052, 2278, 4704, 2256, 13225, 15465, 16, 3760, 7582, 3468, 2001, 16, 2014, 3064, 3]}]}
{"query": {"id": "q_3067", "content": "acetazolamide [SEP] reatment for periodic paralysis and myotonia. Three patients on acetazolamide (15%) developed renal calculi. Extracorporeal lithotripsy succe", "tokenized_content": [2, 4118, 21585, 2261, 3, 1964, 7647, 1958, 12922, 18973, 1930, 15924, 5405, 2126, 18, 2559, 2132, 1990, 4118, 21585, 2261, 12, 2461, 9, 13, 3530, 4604, 2799, 13004, 18, 26324, 3]}, "items": [{"id": "p_3067", "content": "Acetazolamide [SEP] One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an", "score": 1, "type": null, "tokenized_content": [2, 4118, 21585, 2261, 3, 2340, 1927, 1920, 5056, 1935, 22018, 2051, 4472, 1988, 1977, 8929, 3655, 3316, 3905, 10060, 18, 2176, 1977, 8929, 4707, 2222, 1966, 1925, 3]}]}
{"query": {"id": "q_3068", "content": "renal calculi [SEP] s and myotonia. Three patients on acetazolamide (15%) developed renal calculi. Extracorporeal lithotripsy successfully removed a renal calcul", "tokenized_content": [2, 4604, 2799, 13004, 3, 61, 1930, 15924, 5405, 2126, 18, 2559, 2132, 1990, 4118, 21585, 2261, 12, 2461, 9, 13, 3530, 4604, 2799, 13004, 18, 26324, 10945, 18935, 9196, 6664, 3]}, "items": [{"id": "p_3068", "content": "Kidney Calculi [SEP] Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most conta", "score": 1, "type": null, "tokenized_content": [2, 5245, 2799, 13004, 3, 18183, 1922, 1920, 5245, 16, 5394, 5333, 1922, 1920, 6960, 17, 13607, 3403, 1927, 1920, 5245, 12, 5245, 18152, 13, 18, 2310, 6562, 5304, 1930, 2501, 2120, 1019, 3]}]}
{"query": {"id": "q_3069", "content": "renal calculus [SEP] enal calculi. Extracorporeal lithotripsy successfully removed a renal calculus in one patient and surgery removed a staghorn calculus in anoth", "tokenized_content": [2, 4604, 2799, 9605, 3, 2066, 1923, 2799, 13004, 18, 26324, 10945, 18935, 9196, 6664, 5231, 43, 4604, 2799, 9605, 1922, 2340, 2774, 1930, 3782, 5231, 43, 23891, 2509, 5578, 2799, 3]}, "items": [{"id": "p_3069", "content": "Kidney Calculi [SEP] Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most conta", "score": 1, "type": null, "tokenized_content": [2, 5245, 2799, 13004, 3, 18183, 1922, 1920, 5245, 16, 5394, 5333, 1922, 1920, 6960, 17, 13607, 3403, 1927, 1920, 5245, 12, 5245, 18152, 13, 18, 2310, 6562, 5304, 1930, 2501, 2120, 1019, 3]}]}
{"query": {"id": "q_3070", "content": "calculus [SEP] alculi. Extracorporeal lithotripsy successfully removed a renal calculus in one patient and surgery removed a staghorn calculus in anoth", "tokenized_content": [2, 2799, 9605, 3, 4143, 13004, 18, 26324, 10945, 18935, 9196, 6664, 5231, 43, 4604, 2799, 9605, 1922, 2340, 2774, 1930, 3782, 5231, 43, 23891, 2509, 5578, 2799, 9605, 1922, 28976, 3]}, "items": [{"id": "p_3070", "content": "Calculi [SEP] An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones", "score": 1, "type": null, "tokenized_content": [2, 2799, 13004, 3, 1925, 4552, 16528, 1929, 6966, 6969, 1922, 1920, 7075, 1930, 13210, 14810, 16, 5394, 7179, 1927, 8463, 16028, 18, 2222, 6043, 18183, 3]}]}
{"query": {"id": "q_3071", "content": "Nephrolithiasis [SEP] nued treatment. Renal function remained normal in all patients. Nephrolithiasis is a complication of acetazolamide but does not preclude its us", "tokenized_content": [2, 7737, 2226, 29016, 3, 13232, 1919, 2311, 18, 4604, 2347, 5410, 2791, 1922, 2136, 2132, 18, 7737, 2226, 29016, 1977, 43, 9388, 1927, 4118, 21585, 2261, 2308, 3731, 2084, 23793, 3]}, "items": [{"id": "p_3071", "content": "Nephrolithiasis [SEP] Formation of stones in the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7737, 2226, 29016, 3, 3337, 1927, 18183, 1922, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_3072", "content": "scabies [SEP] Is the treatment of scabies hazardous?", "tokenized_content": [2, 17529, 3821, 1918, 3, 1977, 1920, 2311, 1927, 17529, 3821, 1918, 22194, 35, 3]}, "items": [{"id": "p_3072", "content": "Scabies [SEP] A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular er", "score": 1, "type": null, "tokenized_content": [2, 17529, 3821, 1918, 3, 43, 2120, 29284, 2080, 11276, 4531, 4189, 2007, 1920, 21095, 1927, 1920, 24688, 17453, 14652, 17529, 3821, 14209, 18, 2176, 1977, 4378, 2007, 23563, 12013, 3860, 2168, 2668, 3]}]}
{"query": {"id": "q_3073", "content": "scabies [SEP] Treatment for scabies is usually initiated by general practitioners; most consider li", "tokenized_content": [2, 17529, 3821, 1918, 3, 2311, 1958, 17529, 3821, 1918, 1977, 5394, 7796, 2007, 3335, 11815, 31, 2501, 2782, 2336, 3]}, "items": [{"id": "p_3073", "content": "Scabies [SEP] A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular er", "score": 1, "type": null, "tokenized_content": [2, 17529, 3821, 1918, 3, 43, 2120, 29284, 2080, 11276, 4531, 4189, 2007, 1920, 21095, 1927, 1920, 24688, 17453, 14652, 17529, 3821, 14209, 18, 2176, 1977, 4378, 2007, 23563, 12013, 3860, 2168, 2668, 3]}]}
{"query": {"id": "q_3074", "content": "lindane [SEP] es is usually initiated by general practitioners; most consider lindane (gamma benzene hexachloride) the treatment of choice. Lindane i", "tokenized_content": [2, 16401, 2516, 3, 2376, 1977, 5394, 7796, 2007, 3335, 11815, 31, 2501, 2782, 16401, 2516, 12, 7034, 18536, 7142, 22918, 2261, 13, 1920, 2311, 1927, 6259, 18, 16401, 2516, 51, 3]}, "items": [{"id": "p_3074", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3075", "content": "gamma benzene hexachloride [SEP] ally initiated by general practitioners; most consider lindane (gamma benzene hexachloride) the treatment of choice. Lindane is also widely used as an agr", "tokenized_content": [2, 7034, 18536, 7142, 22918, 2261, 3, 2136, 1012, 7796, 2007, 3335, 11815, 31, 2501, 2782, 16401, 2516, 12, 7034, 18536, 7142, 22918, 2261, 13, 1920, 2311, 1927, 6259, 18, 16401, 3]}, "items": [{"id": "p_3075", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3076", "content": "Lindane [SEP] r lindane (gamma benzene hexachloride) the treatment of choice. Lindane is also widely used as an agricultural and industrial pesticide", "tokenized_content": [2, 16401, 2516, 3, 60, 16401, 2516, 12, 7034, 18536, 7142, 22918, 2261, 13, 1920, 2311, 1927, 6259, 18, 16401, 2516, 1977, 2222, 5673, 2251, 1966, 1925, 12291, 1930, 11181, 19875, 3]}, "items": [{"id": "p_3076", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3077", "content": "toxic to the central nervous system [SEP] s well understood. Evidence is accumulating that lindane can be toxic to the central nervous system and may be associated with aplastic anaemia. Preparations conta", "tokenized_content": [2, 6161, 1942, 1920, 4101, 7580, 2433, 3, 61, 2486, 7372, 18, 3095, 1977, 16040, 1988, 16401, 2516, 2112, 1998, 6161, 1942, 1920, 4101, 7580, 2433, 1930, 2278, 1998, 2458, 1956, 3]}, "items": [{"id": "p_3077", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_3078", "content": "aplastic anaemia [SEP]  toxic to the central nervous system and may be associated with aplastic anaemia. Preparations containing lindane continue to be sold over the c", "tokenized_content": [2, 18373, 4054, 19682, 3, 6161, 1942, 1920, 4101, 7580, 2433, 1930, 2278, 1998, 2458, 1956, 18373, 4054, 19682, 18, 9815, 3165, 16401, 2516, 9085, 1942, 1998, 26042, 2338, 1920, 45, 3]}, "items": [{"id": "p_3078", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_3079", "content": "toxicity [SEP]  at-risk groups, and give adequate warnings regarding potential toxicity.", "tokenized_content": [2, 5532, 3, 2019, 17, 2565, 2671, 16, 1930, 7031, 7485, 18149, 1036, 4667, 2889, 5532, 18, 3]}, "items": [{"id": "p_3079", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3080", "content": "masseter spasm [SEP] Anaesthetists' nightmare: masseter spasm after induction in an undiagnosed case of myotonia congenita.", "tokenized_content": [2, 3411, 2732, 24431, 3, 12023, 24964, 1973, 11, 9609, 19252, 1021, 30, 3411, 2732, 24431, 2256, 4408, 1922, 1925, 24885, 3087, 1927, 15924, 5405, 2126, 8680, 9909, 18, 3]}, "items": [{"id": "p_3080", "content": "Trismus [SEP] Spasmodic contraction of the masseter muscle resulting in forceful jaw closure. This may be seen with a variety of diseases, inc", "score": 1, "type": null, "tokenized_content": [2, 6349, 23084, 3, 24431, 12486, 8332, 1927, 1920, 3411, 2732, 3760, 3864, 1922, 5495, 2903, 16795, 10408, 18, 2052, 2278, 1998, 3945, 1956, 43, 5386, 1927, 3902, 16, 2043, 3]}]}
{"query": {"id": "q_3081", "content": "myotonia congenita [SEP] tmare: masseter spasm after induction in an undiagnosed case of myotonia congenita.", "tokenized_content": [2, 15924, 5405, 2126, 8680, 9909, 3, 18391, 1936, 30, 3411, 2732, 24431, 2256, 4408, 1922, 1925, 24885, 3087, 1927, 15924, 5405, 2126, 8680, 9909, 18, 3]}, "items": [{"id": "p_3081", "content": "Myotonia Congenita [SEP] Inherited myotonic disorders with early childhood onset MYOTONIA. Muscular hypertrophy is common and myotonia may impair ambulat", "score": 1, "type": null, "tokenized_content": [2, 15924, 5405, 2126, 8680, 9909, 3, 12911, 15924, 24970, 4414, 1956, 3120, 7238, 4727, 15924, 5405, 2126, 18, 12330, 11014, 1977, 3059, 1930, 15924, 5405, 2126, 2278, 3960, 26236, 1926, 3]}]}
{"query": {"id": "q_3082", "content": "myotonia congenita [SEP] We report an undiagnosed case of myotonia congenita in a 24-year-old previously healthy primigravida, who developed", "tokenized_content": [2, 15924, 5405, 2126, 8680, 9909, 3, 2038, 3809, 1925, 24885, 3087, 1927, 15924, 5405, 2126, 8680, 9909, 1922, 43, 2686, 17, 2476, 17, 4156, 3024, 4097, 2610, 3770, 9188, 3825, 3]}, "items": [{"id": "p_3082", "content": "Myotonia Congenita [SEP] Inherited myotonic disorders with early childhood onset MYOTONIA. Muscular hypertrophy is common and myotonia may impair ambulat", "score": 1, "type": null, "tokenized_content": [2, 15924, 5405, 2126, 8680, 9909, 3, 12911, 15924, 24970, 4414, 1956, 3120, 7238, 4727, 15924, 5405, 2126, 18, 12330, 11014, 1977, 3059, 1930, 15924, 5405, 2126, 2278, 3960, 26236, 1926, 3]}]}
{"query": {"id": "q_3083", "content": "masseter spasm [SEP] previously healthy primigravida, who developed life threatening masseter spasm following a standard dose of intravenous suxamethonium for indu", "tokenized_content": [2, 3411, 2732, 24431, 3, 3024, 4097, 2610, 3770, 9188, 3825, 16, 2746, 3530, 3308, 13281, 3411, 2732, 24431, 2894, 43, 2970, 3253, 1927, 7307, 2020, 11414, 23568, 15414, 1958, 2063, 3]}, "items": [{"id": "p_3083", "content": "Trismus [SEP] Spasmodic contraction of the masseter muscle resulting in forceful jaw closure. This may be seen with a variety of diseases, inc", "score": 1, "type": null, "tokenized_content": [2, 6349, 23084, 3, 24431, 12486, 8332, 1927, 1920, 3411, 2732, 3760, 3864, 1922, 5495, 2903, 16795, 10408, 18, 2052, 2278, 1998, 3945, 1956, 43, 5386, 1927, 3902, 16, 2043, 3]}]}
{"query": {"id": "q_3084", "content": "suxamethonium [SEP] atening masseter spasm following a standard dose of intravenous suxamethonium for induction of anaesthesia. Neither the patient nor the anaes", "tokenized_content": [2, 2020, 11414, 23568, 15414, 3, 30280, 2989, 3411, 2732, 24431, 2894, 43, 2970, 3253, 1927, 7307, 2020, 11414, 23568, 15414, 1958, 4408, 1927, 17107, 18, 7132, 1920, 2774, 3990, 1920, 3]}, "items": [{"id": "p_3084", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_3085", "content": "Toxicity [SEP] Toxicity in rhesus monkeys following administration of the 8-aminoquinol", "tokenized_content": [2, 5532, 3, 5532, 1922, 16996, 11909, 2894, 4183, 1927, 1920, 28, 17, 3835, 11072, 1945, 3]}, "items": [{"id": "p_3085", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3086", "content": "8-aminoquinoline [SEP] Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-me", "tokenized_content": [2, 28, 17, 3835, 11072, 8419, 3, 5532, 1922, 16996, 11909, 2894, 4183, 1927, 1920, 28, 17, 3835, 11072, 8419, 28, 17, 37, 12, 24, 17, 3835, 17, 54, 17, 4963, 3]}, "items": [{"id": "p_3086", "content": "8-aminoquinoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28, 17, 3835, 11072, 8419, 3, 3]}]}
{"query": {"id": "q_3087", "content": "8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline [SEP] rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511).", "tokenized_content": [2, 28, 17, 37, 12, 24, 17, 3835, 17, 54, 17, 4963, 16119, 2199, 13, 3835, 39, 17, 25, 17, 12, 54, 17, 7142, 2199, 7221, 13, 17, 26, 17, 17954, 3]}, "items": [{"id": "p_3087", "content": "WR 242511 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4573, 21679, 7912, 1009, 3, 3]}]}
{"query": {"id": "q_3088", "content": "WR242511 [SEP] methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511).", "tokenized_content": [2, 4573, 29234, 7912, 1009, 3, 4963, 16119, 2199, 13, 3835, 39, 17, 25, 17, 12, 54, 17, 7142, 2199, 7221, 13, 17, 26, 17, 17954, 17, 24, 17, 4963, 11072, 3]}, "items": [{"id": "p_3088", "content": "WR 242511 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4573, 21679, 7912, 1009, 3, 3]}]}
{"query": {"id": "q_3089", "content": "toxicity [SEP]  that form methemoglobin (MHb) effectively counter cyanide (CN) toxicity. Although MHb formers are generally applied as treatments for C", "tokenized_content": [2, 5532, 3, 1988, 2386, 2295, 1987, 7856, 12, 5146, 1014, 13, 7098, 5836, 26164, 12, 5940, 13, 5532, 18, 2876, 5146, 1014, 8733, 1036, 2032, 4933, 3730, 1966, 4930, 1958, 3]}, "items": [{"id": "p_3089", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3090", "content": "poisoning [SEP] Although MHb formers are generally applied as treatments for CN poisoning, it has been proposed that a stable, long-acting MHb former cou", "tokenized_content": [2, 18722, 3, 2876, 5146, 1014, 8733, 1036, 2032, 4933, 3730, 1966, 4930, 1958, 5940, 18722, 16, 2176, 2258, 2252, 4211, 1988, 43, 4700, 16, 2815, 17, 8290, 5146, 1014, 8733, 3]}, "items": [{"id": "p_3090", "content": "Poisoning [SEP] A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18722, 3, 43, 2625, 2014, 3841, 3360, 4152, 2007, 1920, 14195, 16, 4107, 16, 14728, 1927, 2014, 3395, 1942, 43, 12524, 5899, 18, 3]}]}
{"query": {"id": "q_3091", "content": "8-aminoquinoline [SEP] mer could serve as a CN pretreatment. Using this rationale, the 8-aminoquinoline WR242511, a potent long-lasting MHb former in rodents and beagl", "tokenized_content": [2, 28, 17, 3835, 11072, 8419, 3, 6902, 2578, 7120, 1966, 43, 5940, 9111, 18, 2193, 2052, 13202, 16, 1920, 28, 17, 3835, 11072, 8419, 4573, 29234, 7912, 1009, 16, 43, 3]}, "items": [{"id": "p_3091", "content": "8-aminoquinoline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28, 17, 3835, 11072, 8419, 3, 3]}]}
{"query": {"id": "q_3092", "content": "WR242511 [SEP] s a CN pretreatment. Using this rationale, the 8-aminoquinoline WR242511, a potent long-lasting MHb former in rodents and beagle dogs, w", "tokenized_content": [2, 4573, 29234, 7912, 1009, 3, 61, 43, 5940, 9111, 18, 2193, 2052, 13202, 16, 1920, 28, 17, 3835, 11072, 8419, 4573, 29234, 7912, 1009, 16, 43, 6828, 2815, 17, 11671, 3]}, "items": [{"id": "p_3092", "content": "WR 242511 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4573, 21679, 7912, 1009, 3, 3]}]}
{"query": {"id": "q_3093", "content": "methemoglobinemia [SEP] LTS: The selected doses of WR242511, which produced significant methemoglobinemia in beagle dogs in earlier studies conducted elsewhere, produced", "tokenized_content": [2, 2295, 1987, 7856, 3847, 3, 3457, 1036, 30, 1920, 3790, 5312, 1927, 4573, 29234, 7912, 1009, 16, 2154, 4152, 2228, 2295, 1987, 7856, 3847, 1922, 1998, 15915, 1021, 7894, 1922, 3]}, "items": [{"id": "p_3093", "content": "Methemoglobinemia [SEP] The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood norma", "score": 1, "type": null, "tokenized_content": [2, 2295, 1987, 7856, 3847, 3, 1920, 2990, 1927, 2295, 1987, 7856, 1922, 1920, 2877, 16, 3864, 1922, 26898, 8362, 18, 43, 2858, 4351, 1927, 2295, 1987, 7856, 1977, 2481, 1922, 1920, 2877, 5308, 1019, 3]}]}
{"query": {"id": "q_3094", "content": "hemoglobinuria [SEP]  MHb (mean < 2.0%) in the rhesus monkey. Furthermore, transient hemoglobinuria was noted approximately 60 minutes postinjection of WR242511 (3", "tokenized_content": [2, 9652, 8754, 3, 5146, 1014, 12, 2667, 32, 22, 18, 20, 9, 13, 1922, 1920, 16996, 14055, 18, 3677, 16, 6809, 9652, 8754, 1982, 5040, 3993, 3276, 4814, 15633, 7931, 3]}, "items": [{"id": "p_3094", "content": "Hemoglobinuria [SEP] The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating ", "score": 1, "type": null, "tokenized_content": [2, 9652, 8754, 3, 1920, 2990, 1927, 3294, 9652, 1922, 1920, 6960, 16, 4168, 22409, 1927, 14161, 2651, 1920, 4541, 2433, 18, 2256, 24305, 3]}]}
{"query": {"id": "q_3095", "content": "Myoglobinuria [SEP] ties occurred (one IV and one PO) following the 7.0 mg/kg dose. Myoglobinuria was also observed following the 7.0 mg/kg dose. Histopathology ", "tokenized_content": [2, 15924, 4365, 17428, 1022, 8754, 3, 25439, 4807, 12, 2340, 4370, 1930, 2340, 2510, 13, 2894, 1920, 27, 18, 20, 2786, 19, 3621, 3253, 18, 15924, 4365, 17428, 1022, 8754, 3]}, "items": [{"id": "p_3095", "content": "Myoglobinuria [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15924, 4365, 17428, 1022, 8754, 3, 3]}]}
{"query": {"id": "q_3096", "content": "kidney toxicity [SEP] athology analyses in the 2 animals that died revealed liver and kidney toxicity, with greater severity in the orally-treated animal. CONCLUSION", "tokenized_content": [2, 5245, 5532, 3, 9468, 2591, 3247, 1922, 1920, 22, 3555, 1988, 8545, 3404, 3568, 1930, 5245, 5532, 16, 1956, 3430, 5155, 1922, 1920, 12950, 17, 2868, 4027, 18, 4180, 3]}, "items": [{"id": "p_3096", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3097", "content": "hearing loss [SEP] sticity of the adult primate auditory cortex following cochlear hearing loss.", "tokenized_content": [2, 8512, 3257, 3, 14243, 1999, 1927, 1920, 4160, 16305, 8401, 4997, 2894, 15865, 8512, 3257, 18, 3]}, "items": [{"id": "p_3097", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_3098", "content": "hearing loss [SEP] changes occur in this tonotopic organization following cochlear hearing loss. Under anesthesia, the superior temporal gyrus of adult macaque", "tokenized_content": [2, 8512, 3257, 3, 2840, 4704, 1922, 2052, 16501, 14409, 5901, 2894, 15865, 8512, 3257, 18, 2441, 8871, 16, 1920, 6566, 5338, 10774, 1927, 4160, 20533, 3]}, "items": [{"id": "p_3098", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_3099", "content": "kanamycin [SEP] he monkeys were selectively deafened for high frequencies using kanamycin and furosemide. The actual frequencies deafened were determined", "tokenized_content": [2, 19404, 3, 2234, 11909, 1985, 9331, 17793, 5106, 1958, 2149, 6458, 2193, 19404, 1930, 30509, 18, 1920, 7432, 6458, 17793, 5106, 1985, 3180, 3]}, "items": [{"id": "p_3099", "content": "Kanamycin [SEP] Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major com", "score": 1, "type": null, "tokenized_content": [2, 19404, 3, 7267, 2796, 4152, 2007, 22874, 12916, 26984, 1972, 2002, 1957, 2037, 10405, 6072, 18, 12936, 23, 4178, 30, 19404, 43, 16, 1920, 3044, 2008, 3]}]}
{"query": {"id": "q_3100", "content": "furosemide [SEP] e selectively deafened for high frequencies using kanamycin and furosemide. The actual frequencies deafened were determined by the loss of", "tokenized_content": [2, 30509, 3, 47, 9331, 17793, 5106, 1958, 2149, 6458, 2193, 19404, 1930, 30509, 18, 1920, 7432, 6458, 17793, 5106, 1985, 3180, 2007, 1920, 3257, 1927, 3]}, "items": [{"id": "p_3100", "content": "Furosemide [SEP] A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFF", "score": 1, "type": null, "tokenized_content": [2, 30509, 3, 43, 19225, 1935, 17, 26265, 5482, 17, 28028, 1022, 18, 2176, 1977, 43, 26829, 1956, 5867, 4727, 1930, 3662, 4392, 1988, 1977, 2251, 1958, 10144, 1930, 3724, 4604, 7697, 2040, 3]}]}
{"query": {"id": "q_3101", "content": "sumatriptan [SEP] The site of common side effects of sumatriptan.", "tokenized_content": [2, 3578, 12078, 14302, 1928, 3, 1920, 3200, 1927, 3059, 4159, 2564, 1927, 3578, 12078, 14302, 1928, 18, 3]}, "items": [{"id": "p_3101", "content": "Sumatriptan [SEP] A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3578, 12078, 14302, 1928, 3, 43, 11153, 7829, 1988, 8016, 9331, 2019, 29621, 1009, 4086, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 13258, 4414, 18, 3]}]}
{"query": {"id": "q_3102", "content": "Atypical sensations [SEP] Atypical sensations following the use of subcutaneous sumatriptan are common, but o", "tokenized_content": [2, 10834, 26498, 3, 10834, 26498, 2894, 1920, 2485, 1927, 8634, 3578, 12078, 14302, 1928, 2032, 3059, 16, 2308, 57, 3]}, "items": [{"id": "p_3102", "content": "Paresthesia [SEP] Subjective cutaneous sensations (e.g., cold, warmth, tingling, pressure, etc.) that are experienced spontaneously in the absence", "score": 1, "type": null, "tokenized_content": [2, 2096, 29259, 3, 9106, 11276, 26498, 12, 47, 18, 49, 18, 16, 6685, 16, 10142, 1963, 16, 12347, 4365, 1941, 16, 3772, 16, 8289, 18, 13, 1988, 2032, 6090, 12753, 1922, 1920, 3905, 3]}]}
{"query": {"id": "q_3103", "content": "sumatriptan [SEP] Atypical sensations following the use of subcutaneous sumatriptan are common, but of uncertain origin. They are almost always ben", "tokenized_content": [2, 3578, 12078, 14302, 1928, 3, 10834, 26498, 2894, 1920, 2485, 1927, 8634, 3578, 12078, 14302, 1928, 2032, 3059, 16, 2308, 1927, 7323, 4853, 18, 2611, 2032, 5365, 6789, 7129, 3]}, "items": [{"id": "p_3103", "content": "Sumatriptan [SEP] A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3578, 12078, 14302, 1928, 3, 43, 11153, 7829, 1988, 8016, 9331, 2019, 29621, 1009, 4086, 18, 2176, 1977, 2251, 1922, 1920, 2311, 1927, 13258, 4414, 18, 3]}]}
{"query": {"id": "q_3104", "content": "tingling or burning sensations [SEP] s adverse event by the patient. Two patients are presented with tingling or burning sensations limited to areas of heat exposure or sunburn. In these individu", "tokenized_content": [2, 12347, 4365, 1941, 2014, 22873, 26498, 3, 61, 5246, 4817, 2007, 1920, 2774, 18, 2288, 2132, 2032, 3549, 1956, 12347, 4365, 1941, 2014, 22873, 26498, 3892, 1942, 3957, 1927, 5631, 3]}, "items": [{"id": "p_3104", "content": "Paresthesia [SEP] Subjective cutaneous sensations (e.g., cold, warmth, tingling, pressure, etc.) that are experienced spontaneously in the absence", "score": 1, "type": null, "tokenized_content": [2, 2096, 29259, 3, 9106, 11276, 26498, 12, 47, 18, 49, 18, 16, 6685, 16, 10142, 1963, 16, 12347, 4365, 1941, 16, 3772, 16, 8289, 18, 13, 1988, 2032, 6090, 12753, 1922, 1920, 3905, 3]}]}
{"query": {"id": "q_3105", "content": "sunburn [SEP] ling or burning sensations limited to areas of heat exposure or sunburn. In these individuals, side effects are most likely generated s", "tokenized_content": [2, 8147, 23475, 3, 12296, 2014, 22873, 26498, 3892, 1942, 3957, 1927, 5631, 3395, 2014, 8147, 23475, 18, 1922, 2144, 3445, 16, 4159, 2564, 2032, 2501, 3205, 3999, 61, 3]}, "items": [{"id": "p_3105", "content": "Sunburn [SEP] An injury to the skin causing erythema, tenderness, and sometimes blistering and resulting from excessive exposure to the sun. T", "score": 1, "type": null, "tokenized_content": [2, 8147, 23475, 3, 1925, 4047, 1942, 1920, 4407, 7538, 23349, 16, 25900, 16, 1930, 8929, 2266, 7263, 1941, 1930, 3864, 2037, 9122, 3395, 1942, 1920, 8147, 18, 62, 3]}]}
{"query": {"id": "q_3106", "content": "Tremor [SEP] Tremor side effects of salbutamol, quantified by a laser pointer techn", "tokenized_content": [2, 18388, 3, 18388, 4159, 2564, 1927, 3370, 16119, 20624, 16, 6395, 2007, 43, 6033, 3575, 1915, 2913, 3]}, "items": [{"id": "p_3106", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_3107", "content": "salbutamol [SEP] Tremor side effects of salbutamol, quantified by a laser pointer technique.", "tokenized_content": [2, 3370, 16119, 20624, 3, 18388, 4159, 2564, 1927, 3370, 16119, 20624, 16, 6395, 2007, 43, 6033, 3575, 1915, 4778, 18, 3]}, "items": [{"id": "p_3107", "content": "Albuterol [SEP] A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared", "score": 1, "type": null, "tokenized_content": [2, 5311, 4834, 1945, 3, 43, 3662, 17, 8290, 4666, 17, 22, 13672, 7829, 1988, 1977, 5985, 2251, 1966, 43, 26272, 3061, 5899, 1942, 2297, 6678, 18, 5311, 4834, 1945, 1977, 4649, 3]}]}
{"query": {"id": "q_3108", "content": "tremor [SEP] OBJECTIVE: To study tremor side effects of salbutamol an easily applicable, quick and low-", "tokenized_content": [2, 18388, 3, 4470, 30, 1942, 2161, 18388, 4159, 2564, 1927, 3370, 16119, 20624, 1925, 7278, 10045, 16, 8385, 1930, 2330, 17, 3]}, "items": [{"id": "p_3108", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_3109", "content": "salbutamol [SEP] OBJECTIVE: To study tremor side effects of salbutamol an easily applicable, quick and low-priced method is needed. A ", "tokenized_content": [2, 3370, 16119, 20624, 3, 4470, 30, 1942, 2161, 18388, 4159, 2564, 1927, 3370, 16119, 20624, 1925, 7278, 10045, 16, 8385, 1930, 2330, 17, 13016, 1007, 2417, 1977, 4500, 18, 43, 3]}, "items": [{"id": "p_3109", "content": "Albuterol [SEP] A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared", "score": 1, "type": null, "tokenized_content": [2, 5311, 4834, 1945, 3, 43, 3662, 17, 8290, 4666, 17, 22, 13672, 7829, 1988, 1977, 5985, 2251, 1966, 43, 26272, 3061, 5899, 1942, 2297, 6678, 18, 5311, 4834, 1945, 1977, 4649, 3]}]}
{"query": {"id": "q_3110", "content": "Tremor [SEP] ference values and the agreement with a questionnaire. METHODS: Tremor was measured using a laser pointer technique. To determine sens", "tokenized_content": [2, 18388, 3, 4635, 2055, 2851, 1930, 1920, 5558, 1956, 43, 5564, 18, 2860, 30, 18388, 1982, 3045, 2193, 43, 6033, 3575, 1915, 4778, 18, 1942, 3415, 2658, 3]}, "items": [{"id": "p_3110", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_3111", "content": "obstructive lung disease [SEP] To determine sensitivity we assessed tremor in 44 patients with obstructive lung disease after administration of cumulative doses of salbutamol. Subject", "tokenized_content": [2, 12234, 3614, 2573, 3, 1942, 3415, 3802, 2038, 3683, 18388, 1922, 4044, 2132, 1956, 12234, 3614, 2573, 2256, 4183, 1927, 8274, 5312, 1927, 3370, 16119, 20624, 18, 5198, 3]}, "items": [{"id": "p_3111", "content": "Lung Diseases, Obstructive [SEP] Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or", "score": 1, "type": null, "tokenized_content": [2, 3614, 3902, 16, 12234, 3, 2967, 4770, 4961, 2007, 10849, 1927, 12335, 16180, 1927, 1920, 3614, 18, 8155, 10849, 2278, 1998, 3939, 16, 3724, 16, 13252, 16, 2014, 3]}]}
{"query": {"id": "q_3112", "content": "Salbutamol [SEP]  measured simultaneously by two independent observers. RESULTS: Salbutamol significantly increased tremor severity in patients in a dose-d", "tokenized_content": [2, 3370, 16119, 20624, 3, 3045, 7159, 2007, 2288, 3484, 14855, 18, 2274, 30, 3370, 16119, 20624, 2567, 2502, 18388, 5155, 1922, 2132, 1922, 43, 3253, 17, 46, 3]}, "items": [{"id": "p_3112", "content": "Albuterol [SEP] A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared", "score": 1, "type": null, "tokenized_content": [2, 5311, 4834, 1945, 3, 43, 3662, 17, 8290, 4666, 17, 22, 13672, 7829, 1988, 1977, 5985, 2251, 1966, 43, 26272, 3061, 5899, 1942, 2297, 6678, 18, 5311, 4834, 1945, 1977, 4649, 3]}]}
{"query": {"id": "q_3113", "content": "venous thromboembolism [SEP] Increased frequency of venous thromboembolism with the combination of docetaxel and thalidomide in patients w", "tokenized_content": [2, 8562, 23821, 3, 2502, 3528, 1927, 8562, 23821, 1956, 1920, 3921, 1927, 17061, 1930, 30184, 1922, 2132, 65, 3]}, "items": [{"id": "p_3113", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_3114", "content": "docetaxel [SEP] sed frequency of venous thromboembolism with the combination of docetaxel and thalidomide in patients with metastatic androgen-independen", "tokenized_content": [2, 17061, 3, 6276, 3528, 1927, 8562, 23821, 1956, 1920, 3921, 1927, 17061, 1930, 30184, 1922, 2132, 1956, 6476, 10817, 17, 5910, 1917, 3]}, "items": [{"id": "p_3114", "content": "docetaxel [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17061, 3, 3]}]}
{"query": {"id": "q_3115", "content": "thalidomide [SEP] of venous thromboembolism with the combination of docetaxel and thalidomide in patients with metastatic androgen-independent prostate cance", "tokenized_content": [2, 30184, 3, 1927, 8562, 23821, 1956, 1920, 3921, 1927, 17061, 1930, 30184, 1922, 2132, 1956, 6476, 10817, 17, 3484, 5683, 2112, 1972, 3]}, "items": [{"id": "p_3115", "content": "Thalidomide [SEP] A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic ef", "score": 1, "type": null, "tokenized_content": [2, 30184, 3, 43, 16057, 7650, 2199, 4911, 19554, 10398, 6373, 1966, 43, 2447, 17, 30434, 4219, 5524, 2057, 25810, 3153, 16, 2308, 19540, 2037, 1920, 10878, 2810, 1942, 18909, 3880, 8485, 3]}]}
{"query": {"id": "q_3116", "content": "prostate cancer [SEP] nd thalidomide in patients with metastatic androgen-independent prostate cancer.", "tokenized_content": [2, 5683, 2539, 3, 8026, 30184, 1922, 2132, 1956, 6476, 10817, 17, 3484, 5683, 2539, 18, 3]}, "items": [{"id": "p_3116", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_3117", "content": "venous thromboembolism [SEP] STUDY OBJECTIVE: To evaluate the frequency of venous thromboembolism (VTE) in patients with advanced androgen-independent prostate c", "tokenized_content": [2, 8562, 23821, 3, 2161, 4470, 30, 1942, 4323, 1920, 3528, 1927, 8562, 23821, 12, 16931, 13, 1922, 2132, 1956, 5570, 10817, 17, 3484, 5683, 45, 3]}, "items": [{"id": "p_3117", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_3118", "content": "VTE [SEP] OBJECTIVE: To evaluate the frequency of venous thromboembolism (VTE) in patients with advanced androgen-independent prostate cancer", "tokenized_content": [2, 16931, 3, 4470, 30, 1942, 4323, 1920, 3528, 1927, 8562, 23821, 12, 16931, 13, 1922, 2132, 1956, 5570, 10817, 17, 3484, 5683, 2539, 3]}, "items": [{"id": "p_3118", "content": "Venous Thromboembolism [SEP] Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8562, 23821, 3, 10849, 1927, 43, 7920, 2014, 14785, 12, 19287, 13, 2007, 43, 2877, 15053, 12, 16705, 13, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_3119", "content": "prostate cancer [SEP] boembolism (VTE) in patients with advanced androgen-independent prostate cancer who were treated with docetaxel alone or in combination with th", "tokenized_content": [2, 5683, 2539, 3, 24603, 17010, 22616, 12, 16931, 13, 1922, 2132, 1956, 5570, 10817, 17, 3484, 5683, 2539, 2746, 1985, 2868, 1956, 17061, 4298, 2014, 1922, 3921, 1956, 1913, 3]}, "items": [{"id": "p_3119", "content": "Prostatic Neoplasms [SEP] Tumors or cancer of the PROSTATE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17879, 15347, 3, 3861, 2014, 2539, 1927, 1920, 5683, 18, 3]}]}
{"query": {"id": "q_3120", "content": "docetaxel [SEP] nced androgen-independent prostate cancer who were treated with docetaxel alone or in combination with thalidomide. DESIGN: Retrospective", "tokenized_content": [2, 17061, 3, 5301, 1919, 10817, 17, 3484, 5683, 2539, 2746, 1985, 2868, 1956, 17061, 4298, 2014, 1922, 3921, 1956, 30184, 18, 3036, 30, 6968, 3]}, "items": [{"id": "p_3120", "content": "docetaxel [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17061, 3, 3]}]}
{"query": {"id": "q_3121", "content": "thalidomide [SEP] er who were treated with docetaxel alone or in combination with thalidomide. DESIGN: Retrospective analysis of a randomized phase II trial.", "tokenized_content": [2, 30184, 3, 2668, 2746, 1985, 2868, 1956, 17061, 4298, 2014, 1922, 3921, 1956, 30184, 18, 3036, 30, 6968, 2333, 1927, 43, 5542, 3193, 2890, 3046, 18, 3]}, "items": [{"id": "p_3121", "content": "Thalidomide [SEP] A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic ef", "score": 1, "type": null, "tokenized_content": [2, 30184, 3, 43, 16057, 7650, 2199, 4911, 19554, 10398, 6373, 1966, 43, 2447, 17, 30434, 4219, 5524, 2057, 25810, 3153, 16, 2308, 19540, 2037, 1920, 10878, 2810, 1942, 18909, 3880, 8485, 3]}]}
{"query": {"id": "q_3122", "content": "toxicity [SEP] 4-week cycle was repeated until there was evidence of excessive toxicity or disease progression. MEASUREMENTS AND MAIN RESULTS: None of ", "tokenized_content": [2, 5532, 3, 24, 17, 2982, 4048, 1982, 5116, 4801, 2276, 1982, 3095, 1927, 9122, 5532, 2014, 2573, 4380, 18, 4146, 1930, 2730, 2274, 30, 6046, 1927, 3]}, "items": [{"id": "p_3122", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3123", "content": "quaternary ammonium [SEP] Sublingual absorption of the quaternary ammonium antiarrhythmic agent, UM-272.", "tokenized_content": [2, 21920, 11944, 3, 20764, 16800, 6726, 1927, 1920, 21920, 11944, 2246, 23246, 4913, 5899, 16, 8736, 17, 22785, 18, 3]}, "items": [{"id": "p_3123", "content": "Quaternary Ammonium Compounds [SEP] Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydroc", "score": 1, "type": null, "tokenized_content": [2, 21920, 11944, 4300, 3, 8383, 1927, 11944, 4300, 16, 14945, 15, 67, 17, 16, 1922, 2154, 2136, 3006, 1927, 1920, 6201, 1036, 18008, 1942, 6634, 2162, 2252, 8403, 1956, 13107, 3]}]}
{"query": {"id": "q_3124", "content": "UM-272 [SEP] ual absorption of the quaternary ammonium antiarrhythmic agent, UM-272.", "tokenized_content": [2, 8736, 17, 22785, 3, 17942, 1024, 6726, 1927, 1920, 21920, 11944, 2246, 23246, 4913, 5899, 16, 8736, 17, 22785, 18, 3]}, "items": [{"id": "p_3124", "content": "pranolium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21227, 11873, 12191, 1989, 3, 3]}]}
{"query": {"id": "q_3125", "content": "UM-272 [SEP] UM-272 (N,N-dimethylpropranolol), a quaternary antiarrhythmic agent, w", "tokenized_content": [2, 8736, 17, 22785, 3, 8736, 17, 22785, 12, 56, 16, 56, 17, 9780, 20194, 17182, 23646, 13, 16, 43, 21920, 2246, 23246, 4913, 5899, 16, 65, 3]}, "items": [{"id": "p_3125", "content": "pranolium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21227, 11873, 12191, 1989, 3, 3]}]}
{"query": {"id": "q_3126", "content": "N,N-dimethylpropranolol [SEP] UM-272 (N,N-dimethylpropranolol), a quaternary antiarrhythmic agent, was administered sublingua", "tokenized_content": [2, 56, 16, 56, 17, 9780, 20194, 17182, 23646, 3, 8736, 17, 22785, 12, 56, 16, 56, 17, 9780, 20194, 17182, 23646, 13, 16, 43, 21920, 2246, 23246, 4913, 5899, 16, 3]}, "items": [{"id": "p_3126", "content": "pranolium [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21227, 11873, 12191, 1989, 3, 3]}]}
{"query": {"id": "q_3127", "content": "ouabain [SEP] ntiarrhythmic agent, was administered sublingually to dogs with ouabain-induced ventricular tachycardias. Both anti-arrhythmic efficacy", "tokenized_content": [2, 26274, 3, 5891, 9475, 5004, 4626, 4913, 5899, 16, 1982, 5254, 20764, 16800, 1954, 1942, 7894, 1956, 26274, 17, 2719, 6493, 17397, 1036, 18, 2321, 2246, 17, 11335, 4913, 4348, 3]}, "items": [{"id": "p_3127", "content": "Ouabain [SEP] A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants ", "score": 1, "type": null, "tokenized_content": [2, 26274, 3, 43, 21129, 3849, 7533, 2261, 7600, 1927, 23120, 2217, 1930, 26175, 4079, 1921, 16, 2926, 2037, 1920, 9869, 1927, 4943, 18547, 1963, 1957, 24689, 1031, 1957, 1930, 2303, 4793, 3]}]}
{"query": {"id": "q_3128", "content": "ventricular tachycardias [SEP] ent, was administered sublingually to dogs with ouabain-induced ventricular tachycardias. Both anti-arrhythmic efficacy and bioavailability were compare", "tokenized_content": [2, 6493, 17397, 1036, 3, 8496, 16, 1982, 5254, 20764, 16800, 1954, 1942, 7894, 1956, 26274, 17, 2719, 6493, 17397, 1036, 18, 2321, 2246, 17, 11335, 4913, 4348, 1930, 13574, 1985, 3]}, "items": [{"id": "p_3128", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_3129", "content": "ventricular tachycardia [SEP] ent, was administered sublingually to dogs with ouabain-induced ventricular tachycardias. Both anti-arrhythmic efficacy and bioavailability were compar", "tokenized_content": [2, 6493, 17397, 3, 8496, 16, 1982, 5254, 20764, 16800, 1954, 1942, 7894, 1956, 26274, 17, 2719, 6493, 17397, 1036, 18, 2321, 2246, 17, 11335, 4913, 4348, 1930, 13574, 1985, 2238, 3]}, "items": [{"id": "p_3129", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_3130", "content": "thrombocytopenia [SEP] Severe thrombocytopenia and haemolytic anaemia associated with ciprofloxacin: a case re", "tokenized_content": [2, 17100, 3, 4010, 17100, 1930, 7105, 6586, 19682, 2458, 1956, 18502, 30, 43, 3087, 1964, 3]}, "items": [{"id": "p_3130", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_3131", "content": "haemolytic anaemia [SEP] Severe thrombocytopenia and haemolytic anaemia associated with ciprofloxacin: a case report with fatal outcome", "tokenized_content": [2, 7105, 6586, 19682, 3, 4010, 17100, 1930, 7105, 6586, 19682, 2458, 1956, 18502, 30, 43, 3087, 3809, 1956, 11990, 3924, 3]}, "items": [{"id": "p_3131", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_3132", "content": "ciprofloxacin [SEP] Severe thrombocytopenia and haemolytic anaemia associated with ciprofloxacin: a case report with fatal outcome.", "tokenized_content": [2, 18502, 3, 4010, 17100, 1930, 7105, 6586, 19682, 2458, 1956, 18502, 30, 43, 3087, 3809, 1956, 11990, 3924, 18, 3]}, "items": [{"id": "p_3132", "content": "Ciprofloxacin [SEP] A broad-spectrum antimicrobial carboxyfluoroquinoline.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18502, 3, 43, 4949, 17, 5648, 8003, 15750, 14592, 1037, 11072, 8419, 18, 3]}]}
{"query": {"id": "q_3133", "content": "ciprofloxacin [SEP] ns associated with fatal outcome are rare during treatment with ciprofloxacin. A 30-year old Caucasian man reported with abdominal pain and j", "tokenized_content": [2, 18502, 3, 4246, 2458, 1956, 11990, 3924, 2032, 5844, 2409, 2311, 1956, 18502, 18, 43, 2627, 17, 2476, 4156, 13472, 2323, 2568, 1956, 6900, 3594, 1930, 52, 3]}, "items": [{"id": "p_3133", "content": "Ciprofloxacin [SEP] A broad-spectrum antimicrobial carboxyfluoroquinoline.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18502, 3, 43, 4949, 17, 5648, 8003, 15750, 14592, 1037, 11072, 8419, 18, 3]}]}
{"query": {"id": "q_3134", "content": "abdominal pain [SEP] t with ciprofloxacin. A 30-year old Caucasian man reported with abdominal pain and jaundice after 3-day administration of oral ciprofloxacin f", "tokenized_content": [2, 6900, 3594, 3, 62, 1956, 18502, 18, 43, 2627, 17, 2476, 4156, 13472, 2323, 2568, 1956, 6900, 3594, 1930, 25314, 2256, 23, 17, 3007, 4183, 1927, 4726, 18502, 48, 3]}, "items": [{"id": "p_3134", "content": "Abdominal Pain [SEP] Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue inju", "score": 1, "type": null, "tokenized_content": [2, 6900, 3594, 3, 15826, 1927, 15335, 16, 8740, 16, 2014, 6024, 1012, 1922, 1920, 6900, 3031, 31, 4933, 2458, 1956, 3183, 4414, 16, 2960, 2831, 1032, 3]}]}
{"query": {"id": "q_3135", "content": "jaundice [SEP] n. A 30-year old Caucasian man reported with abdominal pain and jaundice after 3-day administration of oral ciprofloxacin for a suspect ", "tokenized_content": [2, 25314, 3, 56, 18, 43, 2627, 17, 2476, 4156, 13472, 2323, 2568, 1956, 6900, 3594, 1930, 25314, 2256, 23, 17, 3007, 4183, 1927, 4726, 18502, 1958, 43, 21339, 3]}, "items": [{"id": "p_3135", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_3136", "content": "urinary tract infection [SEP] ter 3-day administration of oral ciprofloxacin for a suspect of urinary tract infection. Clinical evaluations suggested an initial diagnosis of severe ", "tokenized_content": [2, 7075, 6482, 2909, 3, 6005, 23, 17, 3007, 4183, 1927, 4726, 18502, 1958, 43, 21339, 1927, 7075, 6482, 2909, 18, 2535, 11761, 3978, 1925, 3754, 3574, 1927, 4010, 3]}, "items": [{"id": "p_3136", "content": "Urinary Tract Infections [SEP] Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with a", "score": 1, "type": null, "tokenized_content": [2, 7075, 6482, 5024, 3, 3769, 3387, 1927, 1920, 8081, 1927, 1920, 7075, 6482, 1942, 7293, 6254, 1036, 18, 2611, 2032, 3868, 4543, 5024, 1956, 43, 3]}]}
{"query": {"id": "q_3137", "content": "thrombocytopenia [SEP] . Clinical evaluations suggested an initial diagnosis of severe thrombocytopenia and haemolysis. The patient progressively developed petechiae a", "tokenized_content": [2, 17100, 3, 18, 2535, 11761, 3978, 1925, 3754, 3574, 1927, 4010, 17100, 1930, 7105, 6892, 18, 1920, 2774, 13264, 3530, 5889, 2305, 7955, 43, 3]}, "items": [{"id": "p_3137", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_3138", "content": "haemolysis [SEP] s suggested an initial diagnosis of severe thrombocytopenia and haemolysis. The patient progressively developed petechiae and purpura on t", "tokenized_content": [2, 7105, 6892, 3, 61, 3978, 1925, 3754, 3574, 1927, 4010, 17100, 1930, 7105, 6892, 18, 1920, 2774, 13264, 3530, 5889, 2305, 7955, 1930, 25945, 9280, 1990, 62, 3]}, "items": [{"id": "p_3138", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_3139", "content": "petechiae [SEP] bocytopenia and haemolysis. The patient progressively developed petechiae and purpura on thorax and lower limbs. Despite pharmacological ", "tokenized_content": [2, 5889, 2305, 7955, 3, 22289, 2355, 12903, 1930, 7105, 6892, 18, 1920, 2774, 13264, 3530, 5889, 2305, 7955, 1930, 25945, 9280, 1990, 23755, 1930, 2826, 14054, 18, 4281, 7683, 3]}, "items": [{"id": "p_3139", "content": "Purpura [SEP] Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the si", "score": 1, "type": null, "tokenized_content": [2, 25945, 9280, 3, 25945, 2951, 2014, 8084, 2471, 2312, 2863, 18778, 1943, 16, 7278, 7816, 2596, 1920, 14512, 16, 4189, 2007, 10489, 2460, 1920, 3878, 18, 2469, 1920, 5998, 3]}]}
{"query": {"id": "q_3140", "content": "purpura [SEP] d haemolysis. The patient progressively developed petechiae and purpura on thorax and lower limbs. Despite pharmacological and supporti", "tokenized_content": [2, 25945, 9280, 3, 46, 7105, 6892, 18, 1920, 2774, 13264, 3530, 5889, 2305, 7955, 1930, 25945, 9280, 1990, 23755, 1930, 2826, 14054, 18, 4281, 7683, 1930, 3373, 1033, 3]}, "items": [{"id": "p_3140", "content": "Purpura [SEP] Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the si", "score": 1, "type": null, "tokenized_content": [2, 25945, 9280, 3, 25945, 2951, 2014, 8084, 2471, 2312, 2863, 18778, 1943, 16, 7278, 7816, 2596, 1920, 14512, 16, 4189, 2007, 10489, 2460, 1920, 3878, 18, 2469, 1920, 5998, 3]}]}
{"query": {"id": "q_3141", "content": "haemorrhages [SEP] An accurate autopsy revealed most organs with diffuse petechial haemorrhages. No signs of bone marrow depression were found. No thrombi or s", "tokenized_content": [2, 23352, 1036, 3, 1925, 6305, 16740, 3404, 2501, 7393, 1956, 9435, 5889, 2305, 2086, 23352, 1036, 18, 2239, 6879, 1927, 3622, 6599, 4621, 1985, 2435, 18, 2239, 5700, 1033, 2014, 3]}, "items": [{"id": "p_3141", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_3142", "content": "bone marrow depression [SEP] ed most organs with diffuse petechial haemorrhages. No signs of bone marrow depression were found. No thrombi or signs of microangiopathies were obser", "tokenized_content": [2, 3622, 6599, 4621, 3, 3347, 2501, 7393, 1956, 9435, 5889, 2305, 2086, 23352, 1036, 18, 2239, 6879, 1927, 3622, 6599, 4621, 1985, 2435, 18, 2239, 5700, 1033, 2014, 6879, 1927, 3]}, "items": [{"id": "p_3142", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_3143", "content": "thrombi [SEP] haemorrhages. No signs of bone marrow depression were found. No thrombi or signs of microangiopathies were observed in arterial vessels", "tokenized_content": [2, 5700, 1033, 3, 23352, 1036, 18, 2239, 6879, 1927, 3622, 6599, 4621, 1985, 2435, 18, 2239, 5700, 1033, 2014, 6879, 1927, 2703, 9506, 16038, 1985, 2528, 1922, 6624, 7208, 3]}, "items": [{"id": "p_3143", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_3144", "content": "microangiopathies [SEP] ns of bone marrow depression were found. No thrombi or signs of microangiopathies were observed in arterial vessels. Blood and urine cultures did", "tokenized_content": [2, 2703, 9506, 16038, 3, 4246, 1927, 3622, 6599, 4621, 1985, 2435, 18, 2239, 5700, 1033, 2014, 6879, 1927, 2703, 9506, 16038, 1985, 2528, 1922, 6624, 7208, 18, 2877, 1930, 6960, 3]}, "items": [{"id": "p_3144", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_3145", "content": "haemolytic anaemia [SEP] ofloxacin may precipitate life-threatening thrombocytopenia and haemolytic anaemia, even in the early phases of treatment and without apparent pre", "tokenized_content": [2, 7105, 6586, 19682, 3, 1927, 26226, 2278, 18290, 3308, 17, 13281, 17100, 1930, 7105, 6586, 19682, 16, 3385, 1922, 1920, 3120, 7643, 1927, 2311, 1930, 2979, 6273, 2097, 3]}, "items": [{"id": "p_3145", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_3146", "content": "Simvastatin [SEP] Simvastatin-induced bilateral leg compartment syndrome and myonecrosis asso", "tokenized_content": [2, 21555, 3, 21555, 17, 2719, 7787, 6703, 8152, 4741, 1930, 15924, 2912, 2145, 2475, 2088, 1037, 3]}, "items": [{"id": "p_3146", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_3147", "content": "compartment syndrome [SEP] Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism.", "tokenized_content": [2, 8152, 4741, 3, 21555, 17, 2719, 7787, 6703, 8152, 4741, 1930, 15924, 2912, 2145, 2475, 2458, 1956, 19316, 18, 3]}, "items": [{"id": "p_3147", "content": "Compartment Syndromes [SEP] Conditions in which increased pressure within a limited space compromises the BLOOD CIRCULATION and function of tissue within th", "score": 1, "type": null, "tokenized_content": [2, 8152, 12688, 3, 2961, 1922, 2154, 2502, 3772, 2651, 43, 3892, 5230, 15386, 1036, 1920, 2877, 9255, 1930, 2347, 1927, 2960, 2651, 1913, 3]}]}
{"query": {"id": "q_3148", "content": "myonecrosis [SEP] Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism.", "tokenized_content": [2, 15924, 2912, 2145, 2475, 3, 21555, 17, 2719, 7787, 6703, 8152, 4741, 1930, 15924, 2912, 2145, 2475, 2458, 1956, 19316, 18, 3]}, "items": [{"id": "p_3148", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_3149", "content": "hypothyroidism [SEP] ateral leg compartment syndrome and myonecrosis associated with hypothyroidism.", "tokenized_content": [2, 19316, 3, 30280, 7317, 6703, 8152, 4741, 1930, 15924, 2912, 2145, 2475, 2458, 1956, 19316, 18, 3]}, "items": [{"id": "p_3149", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_3150", "content": "hypothyroid [SEP] A 54-year-old hypothyroid male taking thyroxine and simvastatin presented with bilateral ", "tokenized_content": [2, 3483, 5730, 3, 43, 4584, 17, 2476, 17, 4156, 3483, 5730, 4005, 6303, 29423, 1930, 21555, 3549, 1956, 7787, 3]}, "items": [{"id": "p_3150", "content": "Hypothyroidism [SEP] A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL", "score": 1, "type": null, "tokenized_content": [2, 19316, 3, 43, 4741, 1988, 2274, 2037, 20756, 2330, 5512, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 16, 4523, 1942, 43, 3714, 1922, 5342, 3]}]}
{"query": {"id": "q_3151", "content": "thyroxine [SEP] A 54-year-old hypothyroid male taking thyroxine and simvastatin presented with bilateral leg compartment syndro", "tokenized_content": [2, 29423, 3, 43, 4584, 17, 2476, 17, 4156, 3483, 5730, 4005, 6303, 29423, 1930, 21555, 3549, 1956, 7787, 6703, 8152, 4404, 1931, 3]}, "items": [{"id": "p_3151", "content": "Thyroxine [SEP] The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) an", "score": 1, "type": null, "tokenized_content": [2, 29423, 3, 1920, 3044, 6365, 3595, 2037, 1920, 6918, 8359, 18, 29423, 1977, 6653, 3454, 1920, 8594, 2636, 1927, 6941, 1036, 12, 8914, 13025, 26879, 13, 1925, 3]}]}
{"query": {"id": "q_3152", "content": "simvastatin [SEP] A 54-year-old hypothyroid male taking thyroxine and simvastatin presented with bilateral leg compartment syndrome and myonecros", "tokenized_content": [2, 21555, 3, 43, 4584, 17, 2476, 17, 4156, 3483, 5730, 4005, 6303, 29423, 1930, 21555, 3549, 1956, 7787, 6703, 8152, 4741, 1930, 15924, 2912, 2145, 1951, 3]}, "items": [{"id": "p_3152", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_3153", "content": "compartment syndrome [SEP] e taking thyroxine and simvastatin presented with bilateral leg compartment syndrome and myonecrosis. Urgent fasciotomies were performed and the pat", "tokenized_content": [2, 8152, 4741, 3, 47, 6303, 29423, 1930, 21555, 3549, 1956, 7787, 6703, 8152, 4741, 1930, 15924, 2912, 2145, 2475, 18, 15210, 29990, 11957, 2062, 1985, 2593, 1930, 1920, 2917, 3]}, "items": [{"id": "p_3153", "content": "Compartment Syndromes [SEP] Conditions in which increased pressure within a limited space compromises the BLOOD CIRCULATION and function of tissue within th", "score": 1, "type": null, "tokenized_content": [2, 8152, 12688, 3, 2961, 1922, 2154, 2502, 3772, 2651, 43, 3892, 5230, 15386, 1036, 1920, 2877, 9255, 1930, 2347, 1927, 2960, 2651, 1913, 3]}]}
{"query": {"id": "q_3154", "content": "myonecrosis [SEP] mvastatin presented with bilateral leg compartment syndrome and myonecrosis. Urgent fasciotomies were performed and the patient made an une", "tokenized_content": [2, 15924, 2912, 2145, 2475, 3, 24086, 27334, 3549, 1956, 7787, 6703, 8152, 4741, 1930, 15924, 2912, 2145, 2475, 18, 15210, 29990, 11957, 2062, 1985, 2593, 1930, 1920, 2774, 3915, 1925, 3]}, "items": [{"id": "p_3154", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_3155", "content": "arteriopathic [SEP] e increased worldwide use of this drug and its approval for all arteriopathic patients.", "tokenized_content": [2, 12480, 10982, 3, 47, 2502, 8563, 2485, 1927, 2052, 2838, 1930, 2496, 8382, 1958, 2136, 12480, 10982, 2132, 18, 3]}, "items": [{"id": "p_3155", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_3156", "content": "Bile duct hamartoma [SEP] Bile duct hamartoma occurring in association with long-term treatment with danazol.", "tokenized_content": [2, 9619, 10840, 8616, 5263, 2954, 3, 9619, 10840, 8616, 5263, 2954, 6966, 1922, 3279, 1956, 2815, 17, 2576, 2311, 1956, 11434, 10457, 18, 3]}, "items": [{"id": "p_3156", "content": "Bile Duct Neoplasms [SEP] Tumors or cancer of the BILE DUCTS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9619, 10840, 15347, 3, 3861, 2014, 2539, 1927, 1920, 9619, 19277, 18, 3]}]}
{"query": {"id": "q_3157", "content": "hamartoma [SEP] Bile duct hamartoma occurring in association with long-term treatment with danazol.", "tokenized_content": [2, 8616, 5263, 2954, 3, 9619, 10840, 8616, 5263, 2954, 6966, 1922, 3279, 1956, 2815, 17, 2576, 2311, 1956, 11434, 10457, 18, 3]}, "items": [{"id": "p_3157", "content": "Hamartoma [SEP] A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the aff", "score": 1, "type": null, "tokenized_content": [2, 8616, 5263, 2954, 3, 43, 8083, 22138, 18994, 43, 12132, 16, 7179, 1927, 1925, 27342, 1927, 6665, 2094, 1930, 3878, 1988, 7885, 4704, 1922, 1920, 2633, 3]}]}
{"query": {"id": "q_3158", "content": "danazol [SEP] amartoma occurring in association with long-term treatment with danazol.", "tokenized_content": [2, 11434, 10457, 3, 2150, 5263, 2954, 6966, 1922, 3279, 1956, 2815, 17, 2576, 2311, 1956, 11434, 10457, 18, 3]}, "items": [{"id": "p_3158", "content": "Danazol [SEP] A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhib", "score": 1, "type": null, "tokenized_content": [2, 11434, 10457, 3, 43, 6830, 9507, 1956, 2246, 3827, 2175, 22389, 1997, 7039, 1930, 2246, 17, 29345, 4209, 1988, 8016, 1966, 1925, 5477, 10621, 4400, 2031, 2007, 2439, 3]}]}
{"query": {"id": "q_3159", "content": "bile duct hamartoma [SEP] We report a case of bile duct hamartoma which developed in a patient who had been on long-term danazol ", "tokenized_content": [2, 9619, 10840, 8616, 5263, 2954, 3, 2038, 3809, 43, 3087, 1927, 9619, 10840, 8616, 5263, 2954, 2154, 3530, 1922, 43, 2774, 2746, 2430, 2252, 1990, 2815, 17, 2576, 11434, 10457, 3]}, "items": [{"id": "p_3159", "content": "Bile Duct Neoplasms [SEP] Tumors or cancer of the BILE DUCTS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9619, 10840, 15347, 3, 3861, 2014, 2539, 1927, 1920, 9619, 19277, 18, 3]}]}
{"query": {"id": "q_3160", "content": "hamartoma [SEP] We report a case of bile duct hamartoma which developed in a patient who had been on long-term danazol ", "tokenized_content": [2, 8616, 5263, 2954, 3, 2038, 3809, 43, 3087, 1927, 9619, 10840, 8616, 5263, 2954, 2154, 3530, 1922, 43, 2774, 2746, 2430, 2252, 1990, 2815, 17, 2576, 11434, 10457, 3]}, "items": [{"id": "p_3160", "content": "Hamartoma [SEP] A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the aff", "score": 1, "type": null, "tokenized_content": [2, 8616, 5263, 2954, 3, 43, 8083, 22138, 18994, 43, 12132, 16, 7179, 1927, 1925, 27342, 1927, 6665, 2094, 1930, 3878, 1988, 7885, 4704, 1922, 1920, 2633, 3]}]}
{"query": {"id": "q_3161", "content": "danazol [SEP] amartoma which developed in a patient who had been on long-term danazol treatment. Such patients should be under close follow-up, prefe", "tokenized_content": [2, 11434, 10457, 3, 2150, 5263, 2954, 2154, 3530, 1922, 43, 2774, 2746, 2430, 2252, 1990, 2815, 17, 2576, 11434, 10457, 2311, 18, 2427, 2132, 3066, 1998, 2441, 5428, 2396, 17, 3]}, "items": [{"id": "p_3161", "content": "Danazol [SEP] A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhib", "score": 1, "type": null, "tokenized_content": [2, 11434, 10457, 3, 43, 6830, 9507, 1956, 2246, 3827, 2175, 22389, 1997, 7039, 1930, 2246, 17, 29345, 4209, 1988, 8016, 1966, 1925, 5477, 10621, 4400, 2031, 2007, 2439, 3]}]}
{"query": {"id": "q_3162", "content": "liver mass [SEP]  ultrasound examination of the liver. If the patient develops a liver mass, because of non-specific clinical features and imaging appearan", "tokenized_content": [2, 3568, 3411, 3, 7424, 4981, 1927, 1920, 3568, 18, 2647, 1920, 2774, 15143, 43, 3568, 3411, 16, 2882, 1927, 2447, 17, 2487, 2535, 4075, 1930, 3755, 3267, 1928, 3]}, "items": [{"id": "p_3162", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3163", "content": "Granulomatous [SEP] Granulomatous hepatitis due to combination of amoxicillin and clavulanic acid", "tokenized_content": [2, 26676, 3, 26676, 7977, 2810, 1942, 3921, 1927, 24987, 1930, 19887, 5617, 19730, 2687, 3]}, "items": [{"id": "p_3163", "content": "Granuloma [SEP] A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious", "score": 1, "type": null, "tokenized_content": [2, 25675, 3, 43, 4322, 2858, 21106, 3769, 5709, 3165, 10809, 12192, 25983, 16, 4189, 2007, 7465, 1930, 12431, 21577, 4836, 3]}]}
{"query": {"id": "q_3164", "content": "hepatitis [SEP] Granulomatous hepatitis due to combination of amoxicillin and clavulanic acid.", "tokenized_content": [2, 7977, 3, 26676, 7977, 2810, 1942, 3921, 1927, 24987, 1930, 19887, 5617, 19730, 2687, 18, 3]}, "items": [{"id": "p_3164", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3165", "content": "combination of amoxicillin and clavulanic acid [SEP] Granulomatous hepatitis due to combination of amoxicillin and clavulanic acid.", "tokenized_content": [2, 3921, 1927, 24987, 1930, 19887, 5617, 19730, 2687, 3, 26676, 7977, 2810, 1942, 3921, 1927, 24987, 1930, 19887, 5617, 19730, 2687, 18, 3]}, "items": [{"id": "p_3165", "content": "Amoxicillin-Potassium Clavulanate Combination [SEP] A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24987, 17, 9057, 19887, 5617, 5791, 1021, 3921, 3, 43, 4779, 17, 3400, 3921, 1927, 24987, 5083, 10806, 2010, 1930, 9057, 19887, 5617, 5791, 1021, 18, 3]}]}
{"query": {"id": "q_3166", "content": "amoxicillin-clavulanic acid [SEP] We report the case of a patient with amoxicillin-clavulanic acid-induced hepatitis with histologic multiple granulomas. This typ", "tokenized_content": [2, 24987, 17, 19887, 5617, 19730, 2687, 3, 2038, 3809, 1920, 3087, 1927, 43, 2774, 1956, 24987, 17, 19887, 5617, 19730, 2687, 17, 2719, 7977, 1956, 12434, 3137, 27284, 18, 2052, 3]}, "items": [{"id": "p_3166", "content": "Amoxicillin-Potassium Clavulanate Combination [SEP] A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24987, 17, 9057, 19887, 5617, 5791, 1021, 3921, 3, 43, 4779, 17, 3400, 3921, 1927, 24987, 5083, 10806, 2010, 1930, 9057, 19887, 5617, 5791, 1021, 18, 3]}]}
{"query": {"id": "q_3167", "content": "hepatitis [SEP]  the case of a patient with amoxicillin-clavulanic acid-induced hepatitis with histologic multiple granulomas. This type of lesion broade", "tokenized_content": [2, 7977, 3, 1920, 3087, 1927, 43, 2774, 1956, 24987, 17, 19887, 5617, 19730, 2687, 17, 2719, 7977, 1956, 12434, 3137, 27284, 18, 2052, 2601, 1927, 5709, 4949, 1021, 3]}, "items": [{"id": "p_3167", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3168", "content": "granulomas [SEP] llin-clavulanic acid-induced hepatitis with histologic multiple granulomas. This type of lesion broadens the spectrum of liver injury due ", "tokenized_content": [2, 27284, 3, 10748, 1921, 17, 19887, 5617, 19730, 2687, 17, 2719, 7977, 1956, 12434, 3137, 27284, 18, 2052, 2601, 1927, 5709, 4949, 2099, 1920, 5648, 1927, 3568, 4047, 2810, 3]}, "items": [{"id": "p_3168", "content": "Granuloma [SEP] A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious", "score": 1, "type": null, "tokenized_content": [2, 25675, 3, 43, 4322, 2858, 21106, 3769, 5709, 3165, 10809, 12192, 25983, 16, 4189, 2007, 7465, 1930, 12431, 21577, 4836, 3]}]}
{"query": {"id": "q_3169", "content": "liver injury [SEP] ltiple granulomas. This type of lesion broadens the spectrum of liver injury due to this drug combination, mainly represented by a benign ch", "tokenized_content": [2, 3568, 4047, 3, 3457, 13229, 1021, 27284, 18, 2052, 2601, 1927, 5709, 4949, 2099, 1920, 5648, 1927, 3568, 4047, 2810, 1942, 2052, 2838, 3921, 16, 4994, 5960, 2007, 43, 8867, 3]}, "items": [{"id": "p_3169", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3170", "content": "cholestatic syndrome [SEP] ry due to this drug combination, mainly represented by a benign cholestatic syndrome. The association of granulomas and eosinophilia favor an immuno", "tokenized_content": [2, 21211, 2479, 4741, 3, 18650, 2810, 1942, 2052, 2838, 3921, 16, 4994, 5960, 2007, 43, 8867, 21211, 2479, 4741, 18, 1920, 3279, 1927, 27284, 1930, 26887, 7197, 1925, 6595, 3]}, "items": [{"id": "p_3170", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3171", "content": "eosinophilia [SEP]  benign cholestatic syndrome. The association of granulomas and eosinophilia favor an immunoallergic mechanism. As penicillin derivatives an", "tokenized_content": [2, 26887, 3, 8867, 21211, 2479, 4741, 18, 1920, 3279, 1927, 27284, 1930, 26887, 7197, 1925, 6595, 2214, 5237, 2856, 18, 1966, 9957, 8383, 1925, 3]}, "items": [{"id": "p_3171", "content": "Eosinophilia [SEP] Abnormal increase of EOSINOPHILS in the blood, tissues or organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26887, 3, 4552, 2760, 1927, 15854, 1922, 1920, 2877, 16, 3878, 2014, 7393, 18, 3]}]}
{"query": {"id": "q_3172", "content": "penicillin [SEP] anulomas and eosinophilia favor an immunoallergic mechanism. As penicillin derivatives and amoxicillin alone are known to induce such type", "tokenized_content": [2, 9957, 3, 1925, 1944, 4956, 1930, 26887, 7197, 1925, 6595, 2214, 5237, 2856, 18, 1966, 9957, 8383, 1930, 24987, 4298, 2032, 3171, 1942, 4769, 2427, 2601, 3]}, "items": [{"id": "p_3172", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_3173", "content": "amoxicillin [SEP] We report the case of a patient with amoxicillin-clavulanic acid-induced hepatitis with histologic multiple gran", "tokenized_content": [2, 24987, 3, 2038, 3809, 1920, 3087, 1927, 43, 2774, 1956, 24987, 17, 19887, 5617, 19730, 2687, 17, 2719, 7977, 1956, 12434, 3137, 5559, 3]}, "items": [{"id": "p_3173", "content": "Amoxicillin [SEP] A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum ", "score": 1, "type": null, "tokenized_content": [2, 24987, 3, 43, 4949, 17, 5648, 8762, 18801, 4905, 4116, 2002, 7267, 2551, 1942, 17128, 5574, 1988, 2496, 3554, 1942, 6319, 2687, 16299, 2580, 3256, 3]}]}
{"query": {"id": "q_3174", "content": "clavulanic acid [SEP] We report the case of a patient with amoxicillin-clavulanic acid-induced hepatitis with histologic multiple granulomas. This typ", "tokenized_content": [2, 19887, 5617, 19730, 2687, 3, 2038, 3809, 1920, 3087, 1927, 43, 2774, 1956, 24987, 17, 19887, 5617, 19730, 2687, 17, 2719, 7977, 1956, 12434, 3137, 27284, 18, 2052, 2357, 3]}, "items": [{"id": "p_3174", "content": "Clavulanic Acid [SEP] Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces ", "score": 1, "type": null, "tokenized_content": [2, 19887, 5617, 19730, 2687, 3, 19887, 5617, 19730, 2687, 1930, 2496, 16028, 1930, 16785, 18, 1920, 2687, 1977, 43, 10064, 4106, 1927, 4543, 4666, 17, 23023, 5038, 2037, 22874, 3]}]}
{"query": {"id": "q_3175", "content": "Intracranial aneurysms [SEP] Intracranial aneurysms and cocaine abuse: analysis of prognostic indicators.", "tokenized_content": [2, 12179, 16673, 3, 12179, 16673, 1930, 9045, 7764, 30, 2333, 1927, 6750, 8373, 18, 3]}, "items": [{"id": "p_3175", "content": "Intracranial Aneurysm [SEP] Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch", "score": 1, "type": null, "tokenized_content": [2, 12179, 13373, 3, 4552, 2397, 7056, 16908, 2029, 1922, 1920, 4821, 1927, 12179, 2877, 7208, 18, 2501, 3059, 2032, 1920, 12988, 2168, 12, 28195, 13, 16673, 4810, 2019, 6089, 3]}]}
{"query": {"id": "q_3176", "content": "cocaine abuse [SEP] Intracranial aneurysms and cocaine abuse: analysis of prognostic indicators.", "tokenized_content": [2, 9045, 7764, 3, 12179, 16673, 1930, 9045, 7764, 30, 2333, 1927, 6750, 8373, 18, 3]}, "items": [{"id": "p_3176", "content": "Cocaine-Related Disorders [SEP] Disorders related or resulting from use of cocaine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9045, 17, 2712, 4414, 3, 4414, 2712, 2014, 3864, 2037, 2485, 1927, 9045, 18, 3]}]}
{"query": {"id": "q_3177", "content": "subarachnoid hemorrhage [SEP] OBJECTIVE: The outcome of subarachnoid hemorrhage associated with cocaine abuse is reportedly poor. However, no s", "tokenized_content": [2, 23795, 10489, 3, 4470, 30, 1920, 3924, 1927, 23795, 10489, 2458, 1956, 9045, 7764, 1977, 22455, 3930, 18, 2406, 16, 2239, 61, 3]}, "items": [{"id": "p_3177", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_3178", "content": "cocaine abuse [SEP] JECTIVE: The outcome of subarachnoid hemorrhage associated with cocaine abuse is reportedly poor. However, no study in the literature has rep", "tokenized_content": [2, 9045, 7764, 3, 8988, 12323, 30, 1920, 3924, 1927, 23795, 10489, 2458, 1956, 9045, 7764, 1977, 22455, 3930, 18, 2406, 16, 2239, 2161, 1922, 1920, 4431, 2258, 3073, 3]}, "items": [{"id": "p_3178", "content": "Cocaine-Related Disorders [SEP] Disorders related or resulting from use of cocaine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9045, 17, 2712, 4414, 3, 4414, 2712, 2014, 3864, 2037, 2485, 1927, 9045, 18, 3]}]}
{"query": {"id": "q_3179", "content": "cocaine [SEP] JECTIVE: The outcome of subarachnoid hemorrhage associated with cocaine abuse is reportedly poor. However, no study in the literature h", "tokenized_content": [2, 9045, 3, 8988, 12323, 30, 1920, 3924, 1927, 23795, 10489, 2458, 1956, 9045, 7764, 1977, 22455, 3930, 18, 2406, 16, 2239, 2161, 1922, 1920, 4431, 50, 3]}, "items": [{"id": "p_3179", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_3180", "content": "aneurysms [SEP] uring a 6-year period revealed 14 patients with cocaine-related aneurysms. This group was compared with a control group of 135 patients w", "tokenized_content": [2, 16673, 3, 3674, 1941, 43, 26, 17, 2476, 3047, 3404, 2607, 2132, 1956, 9045, 17, 2712, 16673, 18, 2052, 2210, 1982, 2452, 1956, 43, 2285, 2210, 1927, 11477, 2132, 65, 3]}, "items": [{"id": "p_3180", "content": "Aneurysm [SEP] Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM", "score": 1, "type": null, "tokenized_content": [2, 13373, 3, 6598, 2397, 7056, 16908, 2029, 2014, 10791, 17, 3189, 17799, 1922, 1920, 4821, 1927, 2967, 2877, 8072, 12, 9345, 2014, 14785, 13, 2014, 1920, 4003, 12, 4003, 13373, 3]}]}
{"query": {"id": "q_3181", "content": "ruptured aneurysms [SEP] is group was compared with a control group of 135 patients with ruptured aneurysms and no history of cocaine abuse. Age at presentation, time of i", "tokenized_content": [2, 24390, 16673, 3, 1977, 2210, 1982, 2452, 1956, 43, 2285, 2210, 1927, 11477, 2132, 1956, 24390, 16673, 1930, 2239, 4403, 1927, 9045, 7764, 18, 2632, 2019, 6544, 16, 2367, 1927, 3]}, "items": [{"id": "p_3181", "content": "Aneurysm, Ruptured [SEP] The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger ", "score": 1, "type": null, "tokenized_content": [2, 13373, 16, 24390, 3, 1920, 12650, 1941, 2014, 27823, 1927, 1920, 24214, 4821, 1927, 1920, 13373, 1923, 10791, 16, 5394, 3656, 12666, 1919, 2007, 12446, 15473, 3594, 18, 1920, 4733, 15378, 3]}]}
{"query": {"id": "q_3182", "content": "aneurysm [SEP] uring a 6-year period revealed 14 patients with cocaine-related aneurysms. This group was compared with a control group of 135 patients ", "tokenized_content": [2, 13373, 3, 3674, 1941, 43, 26, 17, 2476, 3047, 3404, 2607, 2132, 1956, 9045, 17, 2712, 16673, 18, 2052, 2210, 1982, 2452, 1956, 43, 2285, 2210, 1927, 11477, 2132, 3]}, "items": [{"id": "p_3182", "content": "Aneurysm [SEP] Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM", "score": 1, "type": null, "tokenized_content": [2, 13373, 3, 6598, 2397, 7056, 16908, 2029, 2014, 10791, 17, 3189, 17799, 1922, 1920, 4821, 1927, 2967, 2877, 8072, 12, 9345, 2014, 14785, 13, 2014, 1920, 4003, 12, 4003, 13373, 3]}]}
{"query": {"id": "q_3183", "content": "Cocaine [SEP] me for the patients with cocaine-related aneurysms. CONCLUSION: Cocaine use predisposed aneurysmal rupture at a significantly earlier a", "tokenized_content": [2, 9045, 3, 2142, 1958, 1920, 2132, 1956, 9045, 17, 2712, 16673, 18, 4180, 30, 9045, 2485, 23002, 1007, 13373, 1923, 12460, 2019, 43, 2567, 5556, 43, 3]}, "items": [{"id": "p_3183", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_3184", "content": "aneurysmal rupture [SEP]  cocaine-related aneurysms. CONCLUSION: Cocaine use predisposed aneurysmal rupture at a significantly earlier age and in much smaller aneurysms. C", "tokenized_content": [2, 13373, 1923, 12460, 3, 9045, 17, 2712, 16673, 18, 4180, 30, 9045, 2485, 23002, 1007, 13373, 1923, 12460, 2019, 43, 2567, 5556, 2632, 1930, 1922, 4186, 5322, 16673, 18, 45, 3]}, "items": [{"id": "p_3184", "content": "Aneurysm, Ruptured [SEP] The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger ", "score": 1, "type": null, "tokenized_content": [2, 13373, 16, 24390, 3, 1920, 12650, 1941, 2014, 27823, 1927, 1920, 24214, 4821, 1927, 1920, 13373, 1923, 10791, 16, 5394, 3656, 12666, 1919, 2007, 12446, 15473, 3594, 18, 1920, 4733, 15378, 3]}]}
{"query": {"id": "q_3185", "content": "epileptic [SEP] Anti-epileptic drugs-induced de novo absence seizures.", "tokenized_content": [2, 16304, 3, 2246, 17, 16304, 4195, 17, 2719, 2028, 9441, 3905, 10060, 18, 3]}, "items": [{"id": "p_3185", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_3186", "content": "absence seizures [SEP] Anti-epileptic drugs-induced de novo absence seizures.", "tokenized_content": [2, 3905, 10060, 3, 2246, 17, 16304, 4195, 17, 2719, 2028, 9441, 3905, 10060, 18, 3]}, "items": [{"id": "p_3186", "content": "Epilepsy, Absence [SEP] A childhood seizure disorder characterized by rhythmic electrical brain discharges of generalized onset. Clinical features inclu", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 3905, 3, 43, 7238, 11015, 4770, 4378, 2007, 20275, 8287, 3068, 20805, 1927, 9612, 4727, 18, 2535, 4075, 2296, 1032, 3]}]}
{"query": {"id": "q_3187", "content": "absence epilepsy [SEP] The authors present three patients with de novo absence epilepsy after administration of carbamazepine and vigabatrin. Despite t", "tokenized_content": [2, 3905, 9741, 3, 1920, 3875, 2481, 2559, 2132, 1956, 2028, 9441, 3905, 9741, 2256, 4183, 1927, 30315, 1930, 11505, 20013, 17670, 18, 4281, 62, 3]}, "items": [{"id": "p_3187", "content": "Epilepsy, Absence [SEP] A childhood seizure disorder characterized by rhythmic electrical brain discharges of generalized onset. Clinical features inclu", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 3905, 3, 43, 7238, 11015, 4770, 4378, 2007, 20275, 8287, 3068, 20805, 1927, 9612, 4727, 18, 2535, 4075, 2296, 1032, 3]}]}
{"query": {"id": "q_3188", "content": "carbamazepine [SEP]  patients with de novo absence epilepsy after administration of carbamazepine and vigabatrin. Despite the underlying diseases, the prognosis ", "tokenized_content": [2, 30315, 3, 2132, 1956, 2028, 9441, 3905, 9741, 2256, 4183, 1927, 30315, 1930, 11505, 20013, 17670, 18, 4281, 1920, 5030, 3902, 16, 1920, 6573, 3]}, "items": [{"id": "p_3188", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_3189", "content": "vigabatrin [SEP] novo absence epilepsy after administration of carbamazepine and vigabatrin. Despite the underlying diseases, the prognosis for drug-induce", "tokenized_content": [2, 11505, 20013, 17670, 3, 9441, 3905, 9741, 2256, 4183, 1927, 30315, 1930, 11505, 20013, 17670, 18, 4281, 1920, 5030, 3902, 16, 1920, 6573, 1958, 2838, 17, 4769, 3]}, "items": [{"id": "p_3189", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_3190", "content": "absence seizure [SEP] the underlying diseases, the prognosis for drug-induced de novo absence seizure is good because it subsides rapidly after discontinuing the use", "tokenized_content": [2, 3905, 11015, 3, 1920, 5030, 3902, 16, 1920, 6573, 1958, 2838, 17, 2719, 2028, 9441, 3905, 11015, 1977, 4227, 2882, 2176, 23981, 1918, 6221, 2256, 9035, 13768, 1920, 2485, 3]}, "items": [{"id": "p_3190", "content": "Epilepsy, Absence [SEP] A childhood seizure disorder characterized by rhythmic electrical brain discharges of generalized onset. Clinical features inclu", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 3905, 3, 43, 7238, 11015, 4770, 4378, 2007, 20275, 8287, 3068, 20805, 1927, 9612, 4727, 18, 2535, 4075, 2296, 1032, 3]}]}
{"query": {"id": "q_3191", "content": "gamma-aminobutyric acid [SEP] rapidly after discontinuing the use of the offending drugs. The gamma-aminobutyric acid-transmitted thalamocortical circuitry accounts for a major part", "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 6221, 2256, 9035, 13768, 1920, 2485, 1927, 1920, 4013, 4792, 4195, 18, 1920, 7034, 17, 29093, 2687, 17, 11019, 10645, 16557, 18459, 11053, 1958, 43, 3]}, "items": [{"id": "p_3191", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_3192", "content": "seizure [SEP] rlying diseases, the prognosis for drug-induced de novo absence seizure is good because it subsides rapidly after discontinuing the use", "tokenized_content": [2, 11015, 3, 11929, 4141, 3902, 16, 1920, 6573, 1958, 2838, 17, 2719, 2028, 9441, 3905, 11015, 1977, 4227, 2882, 2176, 23981, 1918, 6221, 2256, 9035, 13768, 1920, 2485, 3]}, "items": [{"id": "p_3192", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3193", "content": "epilepsy [SEP] The authors present three patients with de novo absence epilepsy after administration of carbamazepine and vigabatrin. Despite t", "tokenized_content": [2, 9741, 3, 1920, 3875, 2481, 2559, 2132, 1956, 2028, 9441, 3905, 9741, 2256, 4183, 1927, 30315, 1930, 11505, 20013, 17670, 18, 4281, 62, 3]}, "items": [{"id": "p_3193", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_3194", "content": "absence seizures [SEP] iconvulsants in children with epilepsy and prevent drug-induced absence seizures.", "tokenized_content": [2, 3905, 10060, 3, 3996, 12766, 6325, 2356, 1922, 3069, 1956, 9741, 1930, 4625, 2838, 17, 2719, 3905, 10060, 18, 3]}, "items": [{"id": "p_3194", "content": "Epilepsy, Absence [SEP] A childhood seizure disorder characterized by rhythmic electrical brain discharges of generalized onset. Clinical features inclu", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 3905, 3, 43, 7238, 11015, 4770, 4378, 2007, 20275, 8287, 3068, 20805, 1927, 9612, 4727, 18, 2535, 4075, 2296, 1032, 3]}]}
{"query": {"id": "q_3195", "content": "Procainamide [SEP] Procainamide-induced polymorphous ventricular tachycardia.", "tokenized_content": [2, 9823, 2005, 5482, 3, 9823, 2005, 5482, 17, 2719, 5418, 2080, 6493, 17397, 18, 3]}, "items": [{"id": "p_3195", "content": "Procainamide [SEP] A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9823, 2005, 5482, 3, 43, 2921, 11640, 2246, 23246, 4913, 2838, 1988, 1977, 12171, 17, 2712, 1942, 9823, 5966, 18, 3]}]}
{"query": {"id": "q_3196", "content": "ventricular tachycardia [SEP] Procainamide-induced polymorphous ventricular tachycardia.", "tokenized_content": [2, 6493, 17397, 3, 9823, 2005, 5482, 17, 2719, 5418, 2080, 6493, 17397, 18, 3]}, "items": [{"id": "p_3196", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_3197", "content": "procainamide [SEP] Seven cases of procainamide-induced polymorphous ventricular tachycardia are presented. In ", "tokenized_content": [2, 9823, 2005, 5482, 3, 5260, 2919, 1927, 9823, 2005, 5482, 17, 2719, 5418, 2080, 6493, 17397, 2032, 3549, 18, 1922, 3]}, "items": [{"id": "p_3197", "content": "Procainamide [SEP] A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9823, 2005, 5482, 3, 43, 2921, 11640, 2246, 23246, 4913, 2838, 1988, 1977, 12171, 17, 2712, 1942, 9823, 5966, 18, 3]}]}
{"query": {"id": "q_3198", "content": "ventricular tachycardia [SEP] Seven cases of procainamide-induced polymorphous ventricular tachycardia are presented. In four patients, polymorphous ventricular tachy", "tokenized_content": [2, 6493, 17397, 3, 5260, 2919, 1927, 9823, 2005, 5482, 17, 2719, 5418, 2080, 6493, 17397, 2032, 3549, 18, 1922, 3006, 2132, 16, 5418, 2080, 6493, 12762, 1012, 3]}, "items": [{"id": "p_3198", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_3199", "content": "premature ventricular contractions [SEP] , procainamide was administered orally for treatment of chronic premature ventricular contractions or atrial flutter. These patients had Q-T prolongation and recu", "tokenized_content": [2, 9839, 6493, 15465, 3, 16, 9823, 2005, 5482, 1982, 5254, 12950, 1958, 2311, 1927, 3724, 9839, 6493, 15465, 2014, 9224, 2848, 3519, 1915, 18, 2144, 2132, 2430, 59, 17, 62, 3]}, "items": [{"id": "p_3199", "content": "Ventricular Premature Complexes [SEP] A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS compl", "score": 1, "type": null, "tokenized_content": [2, 6493, 9839, 5048, 3, 43, 2601, 1927, 4435, 18346, 1956, 9839, 15465, 1927, 1920, 4003, 21008, 18, 2176, 1977, 4378, 2007, 1920, 9839, 22355, 6581, 3]}]}
{"query": {"id": "q_3200", "content": "atrial flutter [SEP]  for treatment of chronic premature ventricular contractions or atrial flutter. These patients had Q-T prolongation and recurrent syncope due ", "tokenized_content": [2, 9224, 2848, 3519, 1915, 3, 1958, 2311, 1927, 3724, 9839, 6493, 15465, 2014, 9224, 2848, 3519, 1915, 18, 2144, 2132, 2430, 59, 17, 62, 20334, 1930, 7457, 26742, 2810, 3]}, "items": [{"id": "p_3200", "content": "Atrial Flutter [SEP] Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave", "score": 1, "type": null, "tokenized_content": [2, 9224, 2848, 3519, 1915, 3, 4052, 16, 11499, 9224, 15465, 4189, 2007, 43, 3367, 1927, 8287, 21896, 12382, 1922, 1920, 3659, 20548, 1930, 43, 21747, 4905, 17182, 1031, 5913, 3]}]}
{"query": {"id": "q_3201", "content": "Q-T prolongation [SEP]  ventricular contractions or atrial flutter. These patients had Q-T prolongation and recurrent syncope due to polymorphous ventricular tachycard", "tokenized_content": [2, 59, 17, 62, 20334, 3, 6493, 15465, 2014, 9224, 2848, 3519, 1915, 18, 2144, 2132, 2430, 59, 17, 62, 20334, 1930, 7457, 26742, 2810, 1942, 5418, 2080, 6493, 12762, 2773, 3]}, "items": [{"id": "p_3201", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_3202", "content": "syncope [SEP] rial flutter. These patients had Q-T prolongation and recurrent syncope due to polymorphous ventricular tachycardia. In four patients, ", "tokenized_content": [2, 26742, 3, 27777, 1024, 2848, 3519, 1915, 18, 2144, 2132, 2430, 59, 17, 62, 20334, 1930, 7457, 26742, 2810, 1942, 5418, 2080, 6493, 17397, 18, 1922, 3006, 2132, 16, 3]}, "items": [{"id": "p_3202", "content": "Syncope [SEP] A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presync", "score": 1, "type": null, "tokenized_content": [2, 26742, 3, 43, 6809, 3257, 1927, 16897, 1930, 17198, 11020, 4189, 2007, 9597, 2877, 3426, 1942, 1920, 3068, 12, 51, 18, 47, 18, 16, 3068, 7716, 13, 18, 2244, 2304, 1030, 3]}]}
{"query": {"id": "q_3203", "content": "arrhythmia [SEP]  to polymorphous ventricular tachycardia. In four patients, the arrhythmia was rapidly diagnosed and treated with disappearance of further", "tokenized_content": [2, 18346, 3, 1942, 5418, 2080, 6493, 17397, 18, 1922, 3006, 2132, 16, 1920, 18346, 1982, 6221, 5377, 1930, 2868, 1956, 18271, 1927, 2520, 3]}, "items": [{"id": "p_3203", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_3204", "content": "ventricular fibrillation [SEP] . In two patients, the arrhythmia degenerated into irreversible ventricular fibrillation and both patients died. In the seventh patient, a permanent ven", "tokenized_content": [2, 6493, 13671, 3, 18, 1922, 2288, 2132, 16, 1920, 18346, 23336, 1007, 2460, 14104, 6493, 13671, 1930, 2321, 2132, 8545, 18, 1922, 1920, 21865, 2774, 16, 43, 11047, 8102, 3]}, "items": [{"id": "p_3204", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_3205", "content": "prolonged Q-T syndrome [SEP] ven cases demonstrate that procainamide can produce an acquired prolonged Q-T syndrome with polymorphous ventricular tachycardia.", "tokenized_content": [2, 7171, 59, 17, 62, 4741, 3, 8102, 2919, 4504, 1988, 9823, 2005, 5482, 2112, 5074, 1925, 5815, 7171, 59, 17, 62, 4741, 1956, 5418, 2080, 6493, 17397, 18, 3]}, "items": [{"id": "p_3205", "content": "Long QT Syndrome [SEP] A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by", "score": 1, "type": null, "tokenized_content": [2, 2815, 8877, 4741, 3, 43, 2625, 1988, 1977, 4378, 2007, 9232, 1927, 26589, 1941, 12, 26742, 13, 1930, 7155, 4647, 1927, 6493, 18346, 1966, 3391, 2007, 3]}]}
{"query": {"id": "q_3206", "content": "bradykinin [SEP] Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during ac", "tokenized_content": [2, 25448, 3, 2770, 1927, 2936, 1927, 25448, 11054, 4086, 1922, 7561, 1927, 1920, 2877, 17, 3068, 7104, 2409, 2000, 3]}, "items": [{"id": "p_3206", "content": "Bradykinin [SEP] A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of ", "score": 1, "type": null, "tokenized_content": [2, 25448, 3, 43, 2447, 24010, 16716, 1988, 1977, 23958, 4152, 2037, 25846, 7650, 1922, 1920, 2877, 2597, 2176, 1977, 43, 6828, 2308, 3662, 17, 11698, 5899, 1927, 3]}]}
{"query": {"id": "q_3207", "content": "hypertension [SEP] receptors in disruption of the blood-brain barrier during acute hypertension.", "tokenized_content": [2, 5579, 3, 4086, 1922, 7561, 1927, 1920, 2877, 17, 3068, 7104, 2409, 3939, 5579, 18, 3]}, "items": [{"id": "p_3207", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3208", "content": "hypertension [SEP] ich account for disruption the blood-brain barrier during acute hypertension are not clear. The goal of this study was to determine the role", "tokenized_content": [2, 5579, 3, 14910, 5042, 1958, 7561, 1920, 2877, 17, 3068, 7104, 2409, 3939, 5579, 2032, 2084, 4021, 18, 1920, 6640, 1927, 2052, 2161, 1982, 1942, 3415, 1920, 2770, 3]}, "items": [{"id": "p_3208", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3209", "content": "bradykinin [SEP] of this study was to determine the role of synthesis/release of bradykinin to activate B2 receptors in disruption of the blood-brain barri", "tokenized_content": [2, 25448, 3, 1927, 2052, 2161, 1982, 1942, 3415, 1920, 2770, 1927, 4271, 19, 4012, 1927, 25448, 1942, 6980, 11054, 4086, 1922, 7561, 1927, 1920, 2877, 17, 3068, 5486, 3]}, "items": [{"id": "p_3209", "content": "Bradykinin [SEP] A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of ", "score": 1, "type": null, "tokenized_content": [2, 25448, 3, 43, 2447, 24010, 16716, 1988, 1977, 23958, 4152, 2037, 25846, 7650, 1922, 1920, 2877, 2597, 2176, 1977, 43, 6828, 2308, 3662, 17, 11698, 5899, 1927, 3]}]}
{"query": {"id": "q_3210", "content": "dextran [SEP] ain barrier was quantitated by clearance of fluorescent-labeled dextran before and during phenylephrine-induced acute hypertension in r", "tokenized_content": [2, 15195, 3, 9798, 1022, 7104, 1982, 22294, 2007, 7802, 1927, 6265, 17, 4993, 15195, 3119, 1930, 2409, 27053, 17, 2719, 3939, 5579, 1922, 60, 3]}, "items": [{"id": "p_3210", "content": "Dextrans [SEP] A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagu", "score": 1, "type": null, "tokenized_content": [2, 15195, 1036, 3, 43, 2210, 1927, 3817, 11039, 3915, 2007, 4908, 4802, 18, 15195, 1036, 2032, 2251, 25058, 1966, 3582, 3776, 7305, 2045, 1930, 11693, 2006, 1032, 3]}]}
{"query": {"id": "q_3211", "content": "phenylephrine [SEP] d by clearance of fluorescent-labeled dextran before and during phenylephrine-induced acute hypertension in rats treated with vehicle and Hoe", "tokenized_content": [2, 27053, 3, 46, 2007, 7802, 1927, 6265, 17, 4993, 15195, 3119, 1930, 2409, 27053, 17, 2719, 3939, 5579, 1922, 3615, 2868, 1956, 6463, 1930, 6673, 1021, 3]}, "items": [{"id": "p_3211", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_3212", "content": "Hoe-140 [SEP] ine-induced acute hypertension in rats treated with vehicle and Hoe-140 (0.1 microM). Phenylephrine infusion increased arterial pressur", "tokenized_content": [2, 6673, 1021, 17, 8949, 3, 11116, 17, 2719, 3939, 5579, 1922, 3615, 2868, 1956, 6463, 1930, 6673, 1021, 17, 8949, 12, 20, 18, 21, 7709, 13, 18, 27053, 7386, 2502, 3]}, "items": [{"id": "p_3212", "content": "icatibant [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14784, 4397, 2031, 3, 3]}]}
{"query": {"id": "q_3213", "content": "Phenylephrine [SEP] rtension in rats treated with vehicle and Hoe-140 (0.1 microM). Phenylephrine infusion increased arterial pressure, arteriolar diameter and c", "tokenized_content": [2, 27053, 3, 4341, 3212, 1922, 3615, 2868, 1956, 6463, 1930, 6673, 1021, 17, 8949, 12, 20, 18, 21, 7709, 13, 18, 27053, 7386, 2502, 6624, 3772, 16, 12480, 4362, 5483, 3]}, "items": [{"id": "p_3213", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_3214", "content": "5-azacytidine [SEP] 5-azacytidine potentiates initiation induced by carcinogens in rat liver.", "tokenized_content": [2, 25, 17, 19244, 27932, 5802, 3, 25, 17, 19244, 27932, 5802, 29734, 6035, 2719, 2007, 27031, 1922, 3067, 3568, 18, 3]}, "items": [{"id": "p_3214", "content": "Azacitidine [SEP] A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, ", "score": 1, "type": null, "tokenized_content": [2, 19244, 3349, 10873, 3, 43, 21611, 12980, 1988, 7042, 2678, 16478, 16, 25648, 2678, 5547, 18, 2176, 1977, 2222, 1925, 20330, 9215, 4627, 12191, 2057, 1927, 2702, 5802, 16, 3]}]}
{"query": {"id": "q_3215", "content": "initiation induced by carcinogens [SEP] 5-azacytidine potentiates initiation induced by carcinogens in rat liver.", "tokenized_content": [2, 6035, 2719, 2007, 27031, 3, 25, 17, 19244, 27932, 5802, 29734, 6035, 2719, 2007, 27031, 1922, 3067, 3568, 18, 3]}, "items": [{"id": "p_3215", "content": "Precancerous Conditions [SEP] Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 24436, 15895, 6506, 1957, 2961, 3, 6598, 4028, 1988, 5370, 10042, 1942, 5433, 6558, 18, 12, 2037, 19638, 4702, 16, 3225, 1963, 3347, 13, 3]}]}
{"query": {"id": "q_3216", "content": "initiation of carcinogenic process [SEP] esis that hypomethylation of DNA plays an important role in the initiation of carcinogenic process, 5-azacytidine (5-AzC) (10 mg/kg), an inhibitor of DNA methylat", "tokenized_content": [2, 6035, 1927, 20711, 2585, 3, 11575, 1036, 1988, 27316, 1927, 2678, 5705, 1925, 2715, 2770, 1922, 1920, 6035, 1927, 20711, 2585, 16, 25, 17, 19244, 27932, 5802, 12, 25, 17, 3]}, "items": [{"id": "p_3216", "content": "Precancerous Conditions [SEP] Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 24436, 15895, 6506, 1957, 2961, 3, 6598, 4028, 1988, 5370, 10042, 1942, 5433, 6558, 18, 12, 2037, 19638, 4702, 16, 3225, 1963, 3347, 13, 3]}]}
{"query": {"id": "q_3217", "content": "5-azacytidine [SEP] ys an important role in the initiation of carcinogenic process, 5-azacytidine (5-AzC) (10 mg/kg), an inhibitor of DNA methylation, was given ", "tokenized_content": [2, 25, 17, 19244, 27932, 5802, 3, 24018, 1925, 2715, 2770, 1922, 1920, 6035, 1927, 20711, 2585, 16, 25, 17, 19244, 27932, 5802, 12, 25, 17, 6352, 1030, 13, 12, 2119, 3]}, "items": [{"id": "p_3217", "content": "Azacitidine [SEP] A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, ", "score": 1, "type": null, "tokenized_content": [2, 19244, 3349, 10873, 3, 43, 21611, 12980, 1988, 7042, 2678, 16478, 16, 25648, 2678, 5547, 18, 2176, 1977, 2222, 1925, 20330, 9215, 4627, 12191, 2057, 1927, 2702, 5802, 16, 3]}]}
{"query": {"id": "q_3218", "content": "5-AzC [SEP]  role in the initiation of carcinogenic process, 5-azacytidine (5-AzC) (10 mg/kg), an inhibitor of DNA methylation, was given to rats", "tokenized_content": [2, 25, 17, 6352, 1030, 3, 2770, 1922, 1920, 6035, 1927, 20711, 2585, 16, 25, 17, 19244, 27932, 5802, 12, 25, 17, 6352, 1030, 13, 12, 2119, 2786, 19, 3621, 13, 3]}, "items": [{"id": "p_3218", "content": "Azacitidine [SEP] A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, ", "score": 1, "type": null, "tokenized_content": [2, 19244, 3349, 10873, 3, 43, 21611, 12980, 1988, 7042, 2678, 16478, 16, 25648, 2678, 5547, 18, 2176, 1977, 2222, 1925, 20330, 9215, 4627, 12191, 2057, 1927, 2702, 5802, 16, 3]}]}
{"query": {"id": "q_3219", "content": "benzo[a]-pyrene [SEP] the phase of repair synthesis induced by the three carcinogens, benzo[a]-pyrene (200 mg/kg), N-methyl-N-nitrosourea (60 mg/kg) and 1,2-dimethyl", "tokenized_content": [2, 19225, 37, 43, 39, 17, 23819, 3, 1920, 3193, 1927, 5059, 4271, 2719, 2007, 1920, 2559, 27031, 16, 19225, 37, 43, 39, 17, 23819, 12, 2191, 2786, 19, 3621, 13, 3]}, "items": [{"id": "p_3219", "content": "Benzo(a)pyrene [SEP] A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an envi", "score": 1, "type": null, "tokenized_content": [2, 19225, 12, 43, 13, 23819, 3, 43, 6828, 8718, 1930, 26343, 18, 2176, 1977, 43, 4462, 2436, 8353, 2882, 1927, 2496, 3216, 2564, 1990, 11181, 7066, 16, 1966, 1925, 11118, 1033, 3]}]}
{"query": {"id": "q_3220", "content": "N-methyl-N-nitrosourea [SEP]  induced by the three carcinogens, benzo[a]-pyrene (200 mg/kg), N-methyl-N-nitrosourea (60 mg/kg) and 1,2-dimethylhydrazine (1,2-DMH) (100 mg/kg). The", "tokenized_content": [2, 56, 17, 4963, 17, 56, 17, 16665, 2257, 5376, 3, 2719, 2007, 1920, 2559, 27031, 16, 19225, 37, 43, 39, 17, 23819, 12, 2191, 2786, 19, 3621, 13, 16, 56, 3]}, "items": [{"id": "p_3220", "content": "Methylnitrosourea [SEP] A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4963, 8635, 1997, 1951, 2257, 5376, 3, 43, 16665, 2257, 5376, 3547, 1956, 28912, 16, 20711, 16, 1930, 21977, 3879, 18, 3]}]}
{"query": {"id": "q_3221", "content": "1,2-dimethylhydrazine [SEP] zo[a]-pyrene (200 mg/kg), N-methyl-N-nitrosourea (60 mg/kg) and 1,2-dimethylhydrazine (1,2-DMH) (100 mg/kg). The initiated hepatocytes in the liver w", "tokenized_content": [2, 21, 16, 22, 17, 9780, 10806, 10119, 3, 11906, 37, 43, 39, 17, 23819, 12, 2191, 2786, 19, 3621, 13, 16, 56, 17, 4963, 17, 56, 17, 16665, 2257, 5376, 3]}, "items": [{"id": "p_3221", "content": "1,2-Dimethylhydrazine [SEP] A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental a", "score": 1, "type": null, "tokenized_content": [2, 21, 16, 22, 17, 9780, 10806, 10119, 3, 43, 2678, 28912, 5899, 1988, 2258, 2252, 2522, 1942, 1998, 43, 6828, 26343, 1930, 1977, 5673, 2251, 1942, 4769, 4120, 3861, 1922, 3599, 43, 3]}]}
{"query": {"id": "q_3222", "content": "1,2-DMH [SEP] ), N-methyl-N-nitrosourea (60 mg/kg) and 1,2-dimethylhydrazine (1,2-DMH) (100 mg/kg). The initiated hepatocytes in the liver were assay", "tokenized_content": [2, 21, 16, 22, 17, 3931, 1023, 3, 13, 16, 56, 17, 4963, 17, 56, 17, 16665, 2257, 5376, 12, 3276, 2786, 19, 3621, 13, 1930, 21, 16, 22, 17, 9780, 3]}, "items": [{"id": "p_3222", "content": "1,2-Dimethylhydrazine [SEP] A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental a", "score": 1, "type": null, "tokenized_content": [2, 21, 16, 22, 17, 9780, 10806, 10119, 3, 43, 2678, 28912, 5899, 1988, 2258, 2252, 2522, 1942, 1998, 43, 6828, 26343, 1930, 1977, 5673, 2251, 1942, 4769, 4120, 3861, 1922, 3599, 43, 3]}]}
{"query": {"id": "q_3223", "content": "2-acetylaminofluorene [SEP] ollowing a 2-week selection regimen consisting of dietary 0.02% 2-acetylaminofluorene coupled with a necrogenic dose of CCl4. The results obtained in", "tokenized_content": [2, 22, 17, 6894, 19143, 14592, 2880, 3, 2865, 16496, 1941, 43, 22, 17, 2982, 4367, 8607, 7600, 1927, 6096, 20, 18, 5725, 9, 22, 17, 6894, 19143, 14592, 2880, 6416, 3]}, "items": [{"id": "p_3223", "content": "2-Acetylaminofluorene [SEP] A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic su", "score": 1, "type": null, "tokenized_content": [2, 22, 17, 6894, 19143, 14592, 2880, 3, 43, 6095, 26343, 6098, 2856, 1927, 2936, 7077, 56, 17, 21319, 1942, 1920, 15578, 5076, 13514, 2687, 3489, 2007, 8145, 2020, 3]}]}
{"query": {"id": "q_3224", "content": "CCl4 [SEP] y 0.02% 2-acetylaminofluorene coupled with a necrogenic dose of CCl4. The results obtained indicate that with all three carcinogens,", "tokenized_content": [2, 20786, 3, 67, 20, 18, 5725, 9, 22, 17, 6894, 19143, 14592, 2880, 6416, 1956, 43, 10341, 11216, 3253, 1927, 20786, 18, 1920, 2274, 2926, 3579, 1988, 1956, 2136, 2559, 3]}, "items": [{"id": "p_3224", "content": "Carbon Tetrachloride [SEP] A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic", "score": 1, "type": null, "tokenized_content": [2, 5056, 12470, 11600, 2261, 3, 43, 7596, 1958, 16984, 16, 27751, 16, 7511, 5089, 5675, 16, 4953, 19552, 1918, 16, 19984, 18578, 1918, 16, 1930, 28015, 16, 1930, 43, 6801, 3485, 1922, 1920, 16140, 1927, 6805, 3]}]}
{"query": {"id": "q_3225", "content": "[3H]-5-azadeoxycytidine [SEP] oci/cm2 in rats treated with carcinogen only. Administration of [3H]-5-azadeoxycytidine during the repair synthesis induced by 1,2-DMH further showed t", "tokenized_content": [2, 37, 7648, 39, 17, 25, 17, 19244, 3695, 7221, 27932, 5802, 3, 5084, 1033, 19, 10598, 1922, 3615, 2868, 1956, 26343, 2444, 18, 4183, 1927, 37, 7648, 39, 17, 25, 3]}, "items": [{"id": "p_3225", "content": "decitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2344, 12696, 3, 3]}]}
{"query": {"id": "q_3226", "content": "cytosine [SEP] synthesis induced by 1,2-DMH further showed that 0.019 mol % of cytosine residues in DNA were substituted by the analogue, indicating th", "tokenized_content": [2, 19032, 3, 4271, 2719, 2007, 21, 16, 22, 17, 3931, 1023, 2520, 2594, 1988, 20, 18, 19074, 2629, 9, 1927, 19032, 4248, 1922, 2678, 1985, 11798, 2007, 1920, 12980, 16, 3]}, "items": [{"id": "p_3226", "content": "Cytosine [SEP] A pyrimidine base that is a fundamental unit of nucleic acids.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19032, 3, 43, 21611, 5170, 1988, 1977, 43, 8829, 5344, 1927, 11079, 4576, 18, 3]}]}
{"query": {"id": "q_3227", "content": "emergent rabbit syndrome [SEP] Withdrawal-emergent rabbit syndrome during dose reduction of risperidone.", "tokenized_content": [2, 18252, 6020, 4741, 3, 9594, 17, 18252, 6020, 4741, 2409, 3253, 3378, 1927, 26991, 18, 3]}, "items": [{"id": "p_3227", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_3228", "content": "risperidone [SEP] Withdrawal-emergent rabbit syndrome during dose reduction of risperidone.", "tokenized_content": [2, 26991, 3, 9594, 17, 18252, 6020, 4741, 2409, 3253, 3378, 1927, 26991, 18, 3]}, "items": [{"id": "p_3228", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_3229", "content": "Rabbit syndrome [SEP] Rabbit syndrome (RS) is a rare extrapyramidal side effect caused by prolonged n", "tokenized_content": [2, 6020, 4741, 3, 6020, 4741, 12, 4366, 13, 1977, 43, 5844, 21346, 3553, 25238, 1923, 4159, 2495, 4189, 2007, 7171, 56, 3]}, "items": [{"id": "p_3229", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_3230", "content": "RS [SEP] Rabbit syndrome (RS) is a rare extrapyramidal side effect caused by prolonged neuro", "tokenized_content": [2, 4366, 3, 6020, 4741, 12, 4366, 13, 1977, 43, 5844, 21346, 3553, 25238, 1923, 4159, 2495, 4189, 2007, 7171, 3366, 3]}, "items": [{"id": "p_3230", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_3231", "content": "emergent RS [SEP] ed neuroleptic medication. Here we present a case of withdrawal-emergent RS, which is the first of its kind to be reported. The patient dev", "tokenized_content": [2, 18252, 4366, 3, 3347, 20325, 17920, 6093, 18, 3410, 2038, 2481, 43, 3087, 1927, 9594, 17, 18252, 4366, 16, 2154, 1977, 1920, 2561, 1927, 2496, 6925, 1942, 1998, 2568, 18, 3]}, "items": [{"id": "p_3231", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_3232", "content": "risperidone [SEP]  be reported. The patient developed RS during dose reduction of risperidone. The symptom was treated successfully with trihexyphenidyl anti", "tokenized_content": [2, 26991, 3, 1998, 2568, 18, 1920, 2774, 3530, 4366, 2409, 3253, 3378, 1927, 26991, 18, 1920, 3226, 1982, 2868, 6664, 1956, 5083, 17797, 11397, 28131, 14458, 1024, 2246, 3]}, "items": [{"id": "p_3232", "content": "Risperidone [SEP] A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has ", "score": 1, "type": null, "tokenized_content": [2, 26991, 3, 43, 5328, 14580, 1927, 7964, 8631, 4086, 1930, 11153, 25, 17, 5334, 1028, 4086, 1988, 8016, 1966, 1925, 10834, 17581, 5899, 18, 2176, 2258, 3]}]}
{"query": {"id": "q_3233", "content": "trihexyphenidyl [SEP] ction of risperidone. The symptom was treated successfully with trihexyphenidyl anticholinergic therapy. The underlying mechanism of withdrawal", "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 3369, 2001, 1927, 26991, 18, 1920, 3226, 1982, 2868, 6664, 1956, 5083, 17797, 11397, 28131, 14458, 1024, 5851, 12074, 12745, 3181, 18, 1920, 3]}, "items": [{"id": "p_3233", "content": "Trihexyphenidyl [SEP] One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal ", "score": 1, "type": null, "tokenized_content": [2, 5083, 17797, 11397, 28131, 14458, 1024, 3, 2340, 1927, 1920, 20424, 8290, 20318, 10515, 2251, 1958, 2311, 1927, 10124, 3122, 4414, 1930, 2838, 17, 2719, 21346, 3553, 25238, 1923, 3]}]}
{"query": {"id": "q_3234", "content": "serotonin [SEP] e been related to the pharmacological profile of risperidone, a serotonin-dopamine antagonist, suggesting the pathophysiologic influence ", "tokenized_content": [2, 11153, 3, 47, 2252, 2712, 1942, 1920, 7683, 5174, 1927, 26991, 16, 43, 11153, 17, 7964, 8151, 16, 3783, 1920, 9211, 12649, 4039, 3]}, "items": [{"id": "p_3234", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3235", "content": "dopamine [SEP] ated to the pharmacological profile of risperidone, a serotonin-dopamine antagonist, suggesting the pathophysiologic influence of the se", "tokenized_content": [2, 7964, 3, 30280, 1007, 1942, 1920, 7683, 5174, 1927, 26991, 16, 43, 11153, 17, 7964, 8151, 16, 3783, 1920, 9211, 12649, 4039, 1927, 1920, 2058, 3]}, "items": [{"id": "p_3235", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3236", "content": "Verapamil [SEP] Verapamil withdrawal as a possible cause of myocardial infarction in a hy", "tokenized_content": [2, 23300, 3, 23300, 9594, 1966, 43, 3216, 3936, 1927, 6497, 8358, 1922, 43, 4527, 3]}, "items": [{"id": "p_3236", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_3237", "content": "myocardial infarction [SEP] Verapamil withdrawal as a possible cause of myocardial infarction in a hypertensive woman with a normal coronary angiogram.", "tokenized_content": [2, 6497, 8358, 3, 23300, 9594, 1966, 43, 3216, 3936, 1927, 6497, 8358, 1922, 43, 11706, 10440, 1956, 43, 2791, 5846, 29220, 20087, 18, 3]}, "items": [{"id": "p_3237", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_3238", "content": "hypertensive [SEP] il withdrawal as a possible cause of myocardial infarction in a hypertensive woman with a normal coronary angiogram.", "tokenized_content": [2, 11706, 3, 2614, 9594, 1966, 43, 3216, 3936, 1927, 6497, 8358, 1922, 43, 11706, 10440, 1956, 43, 2791, 5846, 29220, 20087, 18, 3]}, "items": [{"id": "p_3238", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3239", "content": "Verapamil [SEP] Verapamil is an effective and relatively-safe antihypertensive drug. Seri", "tokenized_content": [2, 23300, 3, 23300, 1977, 1925, 3655, 1930, 4322, 17, 7672, 16439, 2838, 18, 2375, 1033, 3]}, "items": [{"id": "p_3239", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_3240", "content": "depression [SEP] dverse effects are uncommon and mainly have been related to the depression of cardiac contractility and conduction, especially when the dr", "tokenized_content": [2, 4621, 3, 11203, 2045, 1021, 2564, 2032, 14403, 1930, 4994, 2162, 2252, 2712, 1942, 1920, 4621, 1927, 4435, 17862, 1930, 12382, 16, 4369, 2469, 1920, 2324, 3]}, "items": [{"id": "p_3240", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_3241", "content": "myocardial infarction [SEP] s combined with beta-blocking agents. We report a case in which myocardial infarction coincided with the introduction of captopril and the withdrawal", "tokenized_content": [2, 6497, 8358, 3, 61, 4252, 1956, 4666, 17, 7472, 4820, 18, 2038, 3809, 43, 3087, 1922, 2154, 6497, 8358, 23746, 1956, 1920, 6935, 1927, 7502, 24863, 1930, 1920, 9594, 3]}, "items": [{"id": "p_3241", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_3242", "content": "captopril [SEP]  which myocardial infarction coincided with the introduction of captopril and the withdrawal of verapamil in a previously asymptomatic wo", "tokenized_content": [2, 7502, 24863, 3, 2154, 6497, 8358, 23746, 1956, 1920, 6935, 1927, 7502, 24863, 1930, 1920, 9594, 1927, 23300, 1922, 43, 3024, 9978, 26334, 3]}, "items": [{"id": "p_3242", "content": "Captopril [SEP] A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoco", "score": 1, "type": null, "tokenized_content": [2, 7502, 24863, 3, 43, 6828, 1930, 2487, 4106, 1927, 3431, 2199, 17, 9137, 18877, 43, 18, 2176, 7644, 1920, 7309, 1927, 10814, 51, 1942, 10814, 2890, 16, 43, 22866, 4879, 3]}]}
{"query": {"id": "q_3243", "content": "verapamil [SEP] ncided with the introduction of captopril and the withdrawal of verapamil in a previously asymptomatic woman with severe hypertension. Po", "tokenized_content": [2, 23300, 3, 14188, 22250, 1956, 1920, 6935, 1927, 7502, 24863, 1930, 1920, 9594, 1927, 23300, 1922, 43, 3024, 9978, 10440, 1956, 4010, 5579, 18, 2510, 3]}, "items": [{"id": "p_3243", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_3244", "content": "hypertension [SEP] wal of verapamil in a previously asymptomatic woman with severe hypertension. Possible mechanisms that involve a verapamil-related increase ", "tokenized_content": [2, 5579, 3, 16567, 1927, 23300, 1922, 43, 3024, 9978, 10440, 1956, 4010, 5579, 18, 3216, 3531, 1988, 8156, 43, 23300, 17, 2712, 2760, 3]}, "items": [{"id": "p_3244", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3245", "content": "catecholamines [SEP] in platelet and/or vascular alpha 2-adrenoreceptor affinity for catecholamines are discussed.", "tokenized_content": [2, 25923, 3, 1922, 7163, 1930, 19, 2014, 4541, 4595, 22, 17, 7206, 24251, 5173, 1958, 25923, 2032, 5601, 18, 3]}, "items": [{"id": "p_3245", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_3246", "content": "meningeal leukemia [SEP] Remission induction of meningeal leukemia with high-dose intravenous methotrexate.", "tokenized_content": [2, 10286, 5243, 8111, 3, 10221, 4408, 1927, 10286, 5243, 8111, 1956, 2149, 17, 3253, 7307, 18031, 18, 3]}, "items": [{"id": "p_3246", "content": "Meningeal Neoplasms [SEP] Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal", "score": 1, "type": null, "tokenized_content": [2, 10286, 5243, 15347, 3, 8867, 1930, 6558, 12847, 4028, 1988, 10149, 2037, 2014, 2812, 4697, 8156, 1920, 10286, 5243, 12275, 1036, 1927, 1920, 3068, 1930, 6071, 3]}]}
{"query": {"id": "q_3247", "content": "methotrexate [SEP] sion induction of meningeal leukemia with high-dose intravenous methotrexate.", "tokenized_content": [2, 18031, 3, 5998, 1916, 4408, 1927, 10286, 5243, 8111, 1956, 2149, 17, 3253, 7307, 18031, 18, 3]}, "items": [{"id": "p_3247", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_3248", "content": "acute lymphoblastic leukemia [SEP] Twenty children with acute lymphoblastic leukemia who developed meningeal disease were treated with a high-dose i", "tokenized_content": [2, 3939, 24403, 8111, 3, 7639, 3069, 1956, 3939, 24403, 8111, 2746, 3530, 10286, 5243, 2573, 1985, 2868, 1956, 43, 2149, 17, 3253, 51, 3]}, "items": [{"id": "p_3248", "content": "Precursor Cell Lymphoblastic Leukemia-Lymphoma [SEP] A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and ot", "score": 1, "type": null, "tokenized_content": [2, 7897, 2024, 24403, 8111, 17, 8636, 3, 43, 12132, 4378, 2007, 6754, 1927, 1920, 11751, 2024, 10416, 4523, 1942, 9122, 3541, 10088, 1922, 1920, 6599, 1930, 7608, 3]}]}
{"query": {"id": "q_3249", "content": "meningeal disease [SEP] Twenty children with acute lymphoblastic leukemia who developed meningeal disease were treated with a high-dose intravenous methotrexate regimen ", "tokenized_content": [2, 10286, 5243, 2573, 3, 7639, 3069, 1956, 3939, 24403, 8111, 2746, 3530, 10286, 5243, 2573, 1985, 2868, 1956, 43, 2149, 17, 3253, 7307, 18031, 8607, 3]}, "items": [{"id": "p_3249", "content": "Central Nervous System Diseases [SEP] Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spi", "score": 1, "type": null, "tokenized_content": [2, 4101, 7580, 2433, 3902, 3, 3902, 1927, 2967, 4594, 1927, 1920, 3068, 12, 2710, 1920, 6329, 21098, 16, 8769, 15895, 2128, 7289, 1916, 16, 3068, 4402, 16, 1930, 12079, 13, 2014, 1920, 15776, 3]}]}
{"query": {"id": "q_3250", "content": "methotrexate [SEP] ped meningeal disease were treated with a high-dose intravenous methotrexate regimen that was designed to achieve and maintain CSF methotrex", "tokenized_content": [2, 18031, 3, 5296, 10286, 5243, 2573, 1985, 2868, 1956, 43, 2149, 17, 3253, 7307, 18031, 8607, 1988, 1982, 4609, 1942, 6230, 1930, 6698, 6399, 17996, 13280, 3]}, "items": [{"id": "p_3250", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_3251", "content": "Leucovorin [SEP] one hour followed by an infusion of 1,200 mg/m2/h for 23 hours. Leucovorin rescue was initiated 12 hours after the end of the infusion wit", "tokenized_content": [2, 9906, 2579, 14258, 3, 2340, 6231, 3489, 2007, 1925, 7386, 1927, 21, 16, 2191, 2786, 19, 6056, 19, 50, 1958, 3020, 3967, 18, 9906, 2579, 14258, 10162, 1982, 7796, 2369, 3]}, "items": [{"id": "p_3251", "content": "Leucovorin [SEP] The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists", "score": 1, "type": null, "tokenized_content": [2, 9906, 2579, 14258, 3, 1920, 3500, 9483, 1927, 19731, 2687, 18, 9906, 2579, 14258, 1977, 2251, 22581, 1966, 2496, 5016, 7012, 1966, 1925, 30483, 7229, 1942, 19731, 2687, 10515, 3]}]}
{"query": {"id": "q_3252", "content": "toxicities [SEP] emission, and 20% obtained a partial remission. The most common toxicities encountered were transient serum transaminase and bilirubin ele", "tokenized_content": [2, 15251, 3, 7184, 16, 1930, 2036, 9, 2926, 43, 5740, 10221, 18, 1920, 2501, 3059, 15251, 11989, 1985, 6809, 3256, 24376, 1930, 15702, 3064, 3]}, "items": [{"id": "p_3252", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3253", "content": "bilirubin [SEP] on toxicities encountered were transient serum transaminase and bilirubin elevations, neutropenia, and mucositis. One patient had focal s", "tokenized_content": [2, 15702, 3, 1990, 15251, 11989, 1985, 6809, 3256, 24376, 1930, 15702, 17554, 16, 18005, 16, 1930, 3422, 19976, 18, 2340, 2774, 2430, 8083, 61, 3]}, "items": [{"id": "p_3253", "content": "Bilirubin [SEP] A bile pigment that is a degradation product of HEME.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15702, 3, 43, 9619, 12905, 1988, 1977, 43, 4877, 4863, 1927, 10954, 18, 3]}]}
{"query": {"id": "q_3254", "content": "neutropenia [SEP] red were transient serum transaminase and bilirubin elevations, neutropenia, and mucositis. One patient had focal seizures and transient he", "tokenized_content": [2, 18005, 3, 2312, 1985, 6809, 3256, 24376, 1930, 15702, 17554, 16, 18005, 16, 1930, 3422, 19976, 18, 2340, 2774, 2430, 8083, 10060, 1930, 6809, 2234, 3]}, "items": [{"id": "p_3254", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_3255", "content": "mucositis [SEP] t serum transaminase and bilirubin elevations, neutropenia, and mucositis. One patient had focal seizures and transient hemiparesis but r", "tokenized_content": [2, 3422, 19976, 3, 62, 3256, 24376, 1930, 15702, 17554, 16, 18005, 16, 1930, 3422, 19976, 18, 2340, 2774, 2430, 8083, 10060, 1930, 6809, 22637, 9392, 1937, 2308, 60, 3]}, "items": [{"id": "p_3255", "content": "Mucositis [SEP] An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vas", "score": 1, "type": null, "tokenized_content": [2, 3422, 19976, 3, 1925, 4531, 1927, 1920, 9680, 1956, 22873, 2014, 12347, 4365, 1941, 15826, 18, 2176, 1977, 4378, 2007, 10260, 1927, 1920, 10364, 8081, 16, 6350, 3]}]}
{"query": {"id": "q_3256", "content": "seizures [SEP] n elevations, neutropenia, and mucositis. One patient had focal seizures and transient hemiparesis but recovered completely. High-dose i", "tokenized_content": [2, 10060, 3, 56, 17554, 16, 18005, 16, 1930, 3422, 19976, 18, 2340, 2774, 2430, 8083, 10060, 1930, 6809, 22637, 9392, 1937, 2308, 8294, 5796, 18, 2149, 17, 3253, 51, 3]}, "items": [{"id": "p_3256", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3257", "content": "transient hemiparesis [SEP]  neutropenia, and mucositis. One patient had focal seizures and transient hemiparesis but recovered completely. High-dose intravenous methotrexate is", "tokenized_content": [2, 6809, 22637, 9392, 1937, 3, 18005, 16, 1930, 3422, 19976, 18, 2340, 2774, 2430, 8083, 10060, 1930, 6809, 22637, 9392, 1937, 2308, 8294, 5796, 18, 2149, 17, 3253, 7307, 18031, 3]}, "items": [{"id": "p_3257", "content": "Paresis [SEP] A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe", "score": 1, "type": null, "tokenized_content": [2, 2096, 2600, 3, 43, 3335, 2576, 17714, 1942, 43, 5809, 1942, 5086, 4647, 1927, 12330, 12175, 16, 14647, 2251, 1966, 43, 26023, 1958, 18973, 12, 4010, 3]}]}
{"query": {"id": "q_3258", "content": "Hypersensitivity [SEP] Hypersensitivity to carbamazepine presenting with a leukemoid reaction, eosinoph", "tokenized_content": [2, 14625, 3, 14625, 1942, 30315, 8326, 1956, 43, 22823, 2642, 3227, 16, 8199, 2688, 3]}, "items": [{"id": "p_3258", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_3259", "content": "carbamazepine [SEP] Hypersensitivity to carbamazepine presenting with a leukemoid reaction, eosinophilia, erythroderm", "tokenized_content": [2, 30315, 3, 14625, 1942, 30315, 8326, 1956, 43, 22823, 2642, 3227, 16, 26887, 16, 25940, 2179, 1035, 3]}, "items": [{"id": "p_3259", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_3260", "content": "leukemoid reaction [SEP] Hypersensitivity to carbamazepine presenting with a leukemoid reaction, eosinophilia, erythroderma, and renal failure.", "tokenized_content": [2, 22823, 2642, 3227, 3, 14625, 1942, 30315, 8326, 1956, 43, 22823, 2642, 3227, 16, 26887, 16, 25940, 2179, 3368, 16, 1930, 4604, 4574, 18, 3]}, "items": [{"id": "p_3260", "content": "Leukemoid Reaction [SEP] A peripheral blood picture resembling that of leukemia or indistinguishable from it on the basis of morphologic appearance alone", "score": 1, "type": null, "tokenized_content": [2, 22823, 2642, 3227, 3, 43, 5009, 2877, 10213, 18994, 1988, 1927, 8111, 2014, 16586, 2037, 2176, 1990, 1920, 4859, 1927, 19599, 7818, 4298, 3]}]}
{"query": {"id": "q_3261", "content": "eosinophilia [SEP] sitivity to carbamazepine presenting with a leukemoid reaction, eosinophilia, erythroderma, and renal failure.", "tokenized_content": [2, 26887, 3, 14949, 10794, 1942, 30315, 8326, 1956, 43, 22823, 2642, 3227, 16, 26887, 16, 25940, 2179, 3368, 16, 1930, 4604, 4574, 18, 3]}, "items": [{"id": "p_3261", "content": "Eosinophilia [SEP] Abnormal increase of EOSINOPHILS in the blood, tissues or organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26887, 3, 4552, 2760, 1927, 15854, 1922, 1920, 2877, 16, 3878, 2014, 7393, 18, 3]}]}
{"query": {"id": "q_3262", "content": "erythroderma [SEP] rbamazepine presenting with a leukemoid reaction, eosinophilia, erythroderma, and renal failure.", "tokenized_content": [2, 25940, 2179, 3368, 3, 6160, 10671, 6931, 12184, 8326, 1956, 43, 22823, 2642, 3227, 16, 26887, 16, 25940, 2179, 3368, 16, 1930, 4604, 4574, 18, 3]}, "items": [{"id": "p_3262", "content": "Dermatitis, Exfoliative [SEP] The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process t", "score": 1, "type": null, "tokenized_content": [2, 18006, 16, 28972, 2178, 3, 1920, 9360, 5668, 1927, 1920, 4407, 2007, 43, 7350, 1012, 16, 19216, 2080, 18006, 6966, 3108, 1966, 43, 4067, 2014, 6079, 2585, 62, 3]}]}
{"query": {"id": "q_3263", "content": "renal failure [SEP] ting with a leukemoid reaction, eosinophilia, erythroderma, and renal failure.", "tokenized_content": [2, 4604, 4574, 3, 12347, 1029, 1956, 43, 22823, 2642, 3227, 16, 26887, 16, 25940, 2179, 3368, 16, 1930, 4604, 4574, 18, 3]}, "items": [{"id": "p_3263", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_3264", "content": "hypersensitivity [SEP] We report a patient in whom hypersensitivity to carbamazepine presented with generalized erythroderma, a sev", "tokenized_content": [2, 14625, 3, 2038, 3809, 43, 2774, 1922, 8566, 14625, 1942, 30315, 3549, 1956, 9612, 25940, 2179, 3368, 16, 43, 28212, 3]}, "items": [{"id": "p_3264", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_3265", "content": "carbamazepine [SEP] We report a patient in whom hypersensitivity to carbamazepine presented with generalized erythroderma, a severe leukemoid rea", "tokenized_content": [2, 30315, 3, 2038, 3809, 43, 2774, 1922, 8566, 14625, 1942, 30315, 3549, 1956, 9612, 25940, 2179, 3368, 16, 43, 4010, 22823, 2642, 1964, 1019, 3]}, "items": [{"id": "p_3265", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_3266", "content": "erythroderma [SEP] om hypersensitivity to carbamazepine presented with generalized erythroderma, a severe leukemoid reaction, eosinophilia, hyponatremia, and r", "tokenized_content": [2, 25940, 2179, 3368, 3, 7254, 14625, 1942, 30315, 3549, 1956, 9612, 25940, 2179, 3368, 16, 43, 4010, 22823, 2642, 3227, 16, 26887, 16, 29758, 6026, 16, 1930, 60, 3]}, "items": [{"id": "p_3266", "content": "Dermatitis, Exfoliative [SEP] The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process t", "score": 1, "type": null, "tokenized_content": [2, 18006, 16, 28972, 2178, 3, 1920, 9360, 5668, 1927, 1920, 4407, 2007, 43, 7350, 1012, 16, 19216, 2080, 18006, 6966, 3108, 1966, 43, 4067, 2014, 6079, 2585, 62, 3]}]}
{"query": {"id": "q_3267", "content": "leukemoid reaction [SEP] carbamazepine presented with generalized erythroderma, a severe leukemoid reaction, eosinophilia, hyponatremia, and renal failure. This is the fir", "tokenized_content": [2, 22823, 2642, 3227, 3, 30315, 3549, 1956, 9612, 25940, 2179, 3368, 16, 43, 4010, 22823, 2642, 3227, 16, 26887, 16, 29758, 6026, 16, 1930, 4604, 4574, 18, 2052, 1977, 1920, 3]}, "items": [{"id": "p_3267", "content": "Leukemoid Reaction [SEP] A peripheral blood picture resembling that of leukemia or indistinguishable from it on the basis of morphologic appearance alone", "score": 1, "type": null, "tokenized_content": [2, 22823, 2642, 3227, 3, 43, 5009, 2877, 10213, 18994, 1988, 1927, 8111, 2014, 16586, 2037, 2176, 1990, 1920, 4859, 1927, 19599, 7818, 4298, 3]}]}
{"query": {"id": "q_3268", "content": "eosinophilia [SEP] ted with generalized erythroderma, a severe leukemoid reaction, eosinophilia, hyponatremia, and renal failure. This is the first report of s", "tokenized_content": [2, 26887, 3, 26080, 1956, 9612, 25940, 2179, 3368, 16, 43, 4010, 22823, 2642, 3227, 16, 26887, 16, 29758, 6026, 16, 1930, 4604, 4574, 18, 2052, 1977, 1920, 2561, 3809, 1927, 3]}, "items": [{"id": "p_3268", "content": "Eosinophilia [SEP] Abnormal increase of EOSINOPHILS in the blood, tissues or organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26887, 3, 4552, 2760, 1927, 15854, 1922, 1920, 2877, 16, 3878, 2014, 7393, 18, 3]}]}
{"query": {"id": "q_3269", "content": "hyponatremia [SEP] alized erythroderma, a severe leukemoid reaction, eosinophilia, hyponatremia, and renal failure. This is the first report of such an unusual", "tokenized_content": [2, 29758, 6026, 3, 15356, 6756, 25940, 2179, 3368, 16, 43, 4010, 22823, 2642, 3227, 16, 26887, 16, 29758, 6026, 16, 1930, 4604, 4574, 18, 2052, 1977, 1920, 2561, 3809, 1927, 3]}, "items": [{"id": "p_3269", "content": "Hyponatremia [SEP] Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 29758, 6026, 3, 6179, 1927, 5227, 1922, 1920, 2877, 31, 7012, 6882, 18, 12, 19638, 4702, 16, 3225, 1963, 3347, 13, 3]}]}
{"query": {"id": "q_3270", "content": "renal failure [SEP] a, a severe leukemoid reaction, eosinophilia, hyponatremia, and renal failure. This is the first report of such an unusual reaction to carbam", "tokenized_content": [2, 4604, 4574, 3, 43, 16, 43, 4010, 22823, 2642, 3227, 16, 26887, 16, 29758, 6026, 16, 1930, 4604, 4574, 18, 2052, 1977, 1920, 2561, 3809, 1927, 2427, 1925, 12236, 3227, 3]}, "items": [{"id": "p_3270", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_3271", "content": "nicotine [SEP] The interpeduncular nucleus regulates nicotine's effects on free-field activity.", "tokenized_content": [2, 9303, 3, 1920, 2107, 7438, 6009, 2168, 5607, 7014, 9303, 11, 61, 2564, 1990, 3294, 17, 3559, 2455, 18, 3]}, "items": [{"id": "p_3271", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_3272", "content": "kainic acid [SEP] Partial lesions were made with kainic acid in the interpeduncular nucleus of the ventral midbrain of the r", "tokenized_content": [2, 24714, 1935, 2687, 3, 5740, 4518, 1985, 3915, 1956, 24714, 1935, 2687, 1922, 1920, 2107, 7438, 6009, 2168, 5607, 1927, 1920, 8420, 18387, 1927, 1920, 60, 3]}, "items": [{"id": "p_3272", "content": "Kainic Acid [SEP] (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digen", "score": 1, "type": null, "tokenized_content": [2, 24714, 1935, 2687, 3, 12, 20759, 17, 12, 22, 4595, 16, 23, 4666, 16, 24, 4666, 13, 13, 17, 22, 17, 15750, 17, 24, 17, 12, 21, 17, 4963, 3184, 8033, 13, 17, 23, 17, 23878, 5802, 13722, 2687, 18, 7249, 28867, 2261, 2926, 2037, 1920, 2312, 4326, 1019, 4325, 1917, 3]}]}
{"query": {"id": "q_3273", "content": "locomotor hypoactivity [SEP] significantly (p < 0.25) blunted the early (<60 min) free-field locomotor hypoactivity caused by nicotine (0.5 mg kg(-1), i.m.), enhanced the later (6", "tokenized_content": [2, 13594, 14395, 5454, 3, 2567, 12, 58, 32, 20, 18, 2637, 13, 21198, 1920, 3120, 12, 32, 3276, 2360, 13, 3294, 17, 3559, 13594, 14395, 5454, 4189, 2007, 9303, 12, 3]}, "items": [{"id": "p_3273", "content": "Movement Disorders [SEP] Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerati", "score": 1, "type": null, "tokenized_content": [2, 5829, 4414, 3, 12688, 2154, 5961, 3890, 26682, 1036, 1966, 43, 27529, 15570, 1927, 1920, 2573, 2585, 18, 3063, 1922, 2052, 6891, 2032, 7223, 7124, 1914, 3]}]}
{"query": {"id": "q_3274", "content": "nicotine [SEP] the early (<60 min) free-field locomotor hypoactivity caused by nicotine (0.5 mg kg(-1), i.m.), enhanced the later (60-120 min) nicotine", "tokenized_content": [2, 9303, 3, 1920, 3120, 12, 32, 3276, 2360, 13, 3294, 17, 3559, 13594, 14395, 5454, 4189, 2007, 9303, 12, 20, 18, 25, 2786, 3621, 12, 17, 21, 13, 16, 51, 3]}, "items": [{"id": "p_3274", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_3275", "content": "hyperactivity [SEP] kg(-1), i.m.), enhanced the later (60-120 min) nicotine-induced hyperactivity, and raised spontaneous nocturnal activity. Lesions reduced the", "tokenized_content": [2, 15534, 3, 3621, 12, 17, 21, 13, 16, 51, 18, 55, 18, 13, 16, 4256, 1920, 3690, 12, 3276, 17, 6103, 2360, 13, 9303, 17, 2719, 15534, 16, 1930, 8930, 3]}, "items": [{"id": "p_3275", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_3276", "content": "choline [SEP] . Lesions reduced the extent of immunohistological staining for choline acetyltransferase in the interpeduncular nucleus (p <0.025), bu", "tokenized_content": [2, 15440, 3, 18, 4518, 3028, 1920, 5064, 1927, 6527, 2477, 4166, 1958, 15440, 22226, 1922, 1920, 2107, 7438, 6009, 2168, 5607, 12, 58, 32, 20, 18, 15008, 13, 16, 3168, 3]}, "items": [{"id": "p_3276", "content": "Choline [SEP] A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine,", "score": 1, "type": null, "tokenized_content": [2, 15440, 3, 43, 5937, 18690, 1927, 18430, 1953, 1921, 1988, 1977, 2435, 1922, 3086, 4793, 1930, 4027, 7393, 18, 2176, 1977, 2715, 1966, 43, 7897, 1927, 14561, 16, 3]}]}
{"query": {"id": "q_3277", "content": "tyrosine [SEP] nsferase in the interpeduncular nucleus (p <0.025), but not for tyrosine hydroxylase in the surrounding catecholaminergic A10 region. We", "tokenized_content": [2, 6941, 3, 21449, 7124, 4127, 1922, 1920, 2107, 7438, 6009, 2168, 5607, 12, 58, 32, 20, 18, 15008, 13, 16, 2308, 2084, 1958, 6941, 16324, 1922, 1920, 7510, 23483, 1005, 3]}, "items": [{"id": "p_3277", "content": "Tyrosine [SEP] A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HO", "score": 1, "type": null, "tokenized_content": [2, 6941, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 1922, 3555, 2176, 1977, 6653, 2037, 17388, 18, 2176, 1977, 2222, 1920, 7897, 1927, 19280, 31, 6918, 6673, 3]}]}
{"query": {"id": "q_3278", "content": "depression [SEP] We conclude that the interpeduncular nucleus mediates nicotinic depression of locomotor activity and dampens nicotinic arousal mechanisms ", "tokenized_content": [2, 4621, 3, 2038, 7676, 1988, 1920, 2107, 7438, 6009, 2168, 5607, 10412, 20239, 4621, 1927, 13594, 2455, 1930, 15515, 2099, 20239, 14216, 3531, 3]}, "items": [{"id": "p_3278", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_3279", "content": "dobutamine [SEP]  new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.", "tokenized_content": [2, 2608, 16119, 3812, 3, 2814, 2447, 17, 6044, 3867, 1927, 4435, 3604, 1958, 3805, 1927, 2608, 16119, 3812, 17, 2719, 6497, 7716, 18, 3]}, "items": [{"id": "p_3279", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_3280", "content": "myocardial ischemia [SEP] ndex of cardiac performance for detection of dobutamine-induced myocardial ischemia.", "tokenized_content": [2, 6497, 7716, 3, 27594, 1039, 1927, 4435, 3604, 1958, 3805, 1927, 2608, 16119, 3812, 17, 2719, 6497, 7716, 18, 3]}, "items": [{"id": "p_3280", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_3281", "content": "dobutamine [SEP] ND: Electrocardiography has a very low sensitivity in detecting dobutamine-induced myocardial ischemia. OBJECTIVES: To assess the added di", "tokenized_content": [2, 2608, 16119, 3812, 3, 8026, 30, 15894, 3796, 2258, 43, 3345, 2330, 3802, 1922, 9227, 2608, 16119, 3812, 17, 2719, 6497, 7716, 18, 7634, 30, 1942, 2634, 1920, 4057, 2137, 3]}, "items": [{"id": "p_3281", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_3282", "content": "myocardial ischemia [SEP] aphy has a very low sensitivity in detecting dobutamine-induced myocardial ischemia. OBJECTIVES: To assess the added diagnostic value of a new card", "tokenized_content": [2, 6497, 7716, 3, 12274, 1012, 2258, 43, 3345, 2330, 3802, 1922, 9227, 2608, 16119, 3812, 17, 2719, 6497, 7716, 18, 7634, 30, 1942, 2634, 1920, 4057, 4785, 3113, 1927, 43, 3]}, "items": [{"id": "p_3282", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_3283", "content": "Tc99m-Sestamibi [SEP] CG, for detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard", "tokenized_content": [2, 5283, 6576, 1035, 17, 9924, 3857, 7395, 3821, 3, 7294, 16, 1958, 9227, 2608, 16119, 3812, 17, 2719, 6497, 7716, 16, 2193, 5283, 6576, 1035, 17, 9924, 3857, 7395, 3821, 3]}, "items": [{"id": "p_3283", "content": "Technetium Tc 99m Sestamibi [SEP] A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2913, 4988, 1989, 5283, 17660, 9924, 3857, 7395, 3821, 3, 43, 2913, 4988, 1989, 3755, 5899, 2251, 1942, 3157, 2877, 17, 17704, 4435, 2960, 2409, 43, 4003, 8926, 18, 3]}]}
{"query": {"id": "q_3284", "content": "ischemia [SEP] very low sensitivity in detecting dobutamine-induced myocardial ischemia. OBJECTIVES: To assess the added diagnostic value of a new card", "tokenized_content": [2, 7716, 3, 3345, 2330, 3802, 1922, 9227, 2608, 16119, 3812, 17, 2719, 6497, 7716, 18, 7634, 30, 1942, 2634, 1920, 4057, 4785, 3113, 1927, 43, 2814, 9429, 3]}, "items": [{"id": "p_3284", "content": "Ischemia [SEP] A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS,", "score": 1, "type": null, "tokenized_content": [2, 7716, 3, 43, 26497, 1915, 9049, 1927, 1920, 2877, 2596, 1925, 3090, 2014, 2960, 4189, 2007, 43, 11896, 19837, 2014, 10849, 1927, 2496, 2877, 7208, 16, 3]}]}
{"query": {"id": "q_3285", "content": "Sestamibi [SEP] r detecting dobutamine-induced myocardial ischemia, using Tc99m-Sestamibi single-photon emission computed tomography as the gold standard", "tokenized_content": [2, 9924, 3857, 7395, 3821, 3, 60, 9227, 2608, 16119, 3812, 17, 2719, 6497, 7716, 16, 2193, 5283, 6576, 1035, 17, 9924, 3857, 7395, 3821, 2957, 17, 11363, 7184, 6287, 7876, 3]}, "items": [{"id": "p_3285", "content": "Technetium Tc 99m Sestamibi [SEP] A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2913, 4988, 1989, 5283, 17660, 9924, 3857, 7395, 3821, 3, 43, 2913, 4988, 1989, 3755, 5899, 2251, 1942, 3157, 2877, 17, 17704, 4435, 2960, 2409, 43, 4003, 8926, 18, 3]}]}
{"query": {"id": "q_3286", "content": "Acute liver failure [SEP] Acute liver failure in two patients with regular alcohol consumption ingesting para", "tokenized_content": [2, 3939, 3568, 4574, 3, 3939, 3568, 4574, 1922, 2288, 2132, 1956, 6314, 4284, 5434, 11378, 2104, 8202, 3]}, "items": [{"id": "p_3286", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_3287", "content": "alcohol [SEP] Acute liver failure in two patients with regular alcohol consumption ingesting paracetamol at therapeutic dosage.", "tokenized_content": [2, 4284, 3, 3939, 3568, 4574, 1922, 2288, 2132, 1956, 6314, 4284, 5434, 11378, 2104, 27021, 2019, 4272, 9998, 18, 3]}, "items": [{"id": "p_3287", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_3288", "content": "paracetamol [SEP] lure in two patients with regular alcohol consumption ingesting paracetamol at therapeutic dosage.", "tokenized_content": [2, 27021, 3, 10908, 1936, 1922, 2288, 2132, 1956, 6314, 4284, 5434, 11378, 2104, 27021, 2019, 4272, 9998, 18, 3]}, "items": [{"id": "p_3288", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_3289", "content": "alcohol [SEP] BACKGROUND: The possible role of alcohol in the development of hepatotoxicity associated with therapeuti", "tokenized_content": [2, 4284, 3, 3872, 30, 1920, 3216, 2770, 1927, 4284, 1922, 1920, 2740, 1927, 24126, 2458, 1956, 4055, 1914, 3]}, "items": [{"id": "p_3289", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_3290", "content": "hepatotoxicity [SEP] BACKGROUND: The possible role of alcohol in the development of hepatotoxicity associated with therapeutic doses of paracetamol (acetaminophen", "tokenized_content": [2, 24126, 3, 3872, 30, 1920, 3216, 2770, 1927, 4284, 1922, 1920, 2740, 1927, 24126, 2458, 1956, 4272, 5312, 1927, 27021, 12, 23311, 3]}, "items": [{"id": "p_3290", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3291", "content": "paracetamol [SEP] elopment of hepatotoxicity associated with therapeutic doses of paracetamol (acetaminophen) is currently debated. CASE REPORT: We describe ", "tokenized_content": [2, 27021, 3, 2349, 2011, 2017, 1927, 24126, 2458, 1956, 4272, 5312, 1927, 27021, 12, 23311, 13, 1977, 5077, 23645, 18, 3087, 3809, 30, 2038, 5993, 3]}, "items": [{"id": "p_3291", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_3292", "content": "acetaminophen [SEP] epatotoxicity associated with therapeutic doses of paracetamol (acetaminophen) is currently debated. CASE REPORT: We describe 2 patients who ", "tokenized_content": [2, 23311, 3, 15369, 4575, 4575, 18068, 3349, 3145, 2458, 1956, 4272, 5312, 1927, 27021, 12, 23311, 13, 1977, 5077, 23645, 18, 3087, 3809, 30, 2038, 5993, 22, 2132, 2746, 3]}, "items": [{"id": "p_3292", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_3293", "content": "liver failure [SEP] atients who were regular consumers of alcohol and who developed liver failure within 3-5 days after hospitalization and stopping alcohol cons", "tokenized_content": [2, 3568, 4574, 3, 2019, 6746, 2746, 1985, 6314, 15085, 1927, 4284, 1930, 2746, 3530, 3568, 4574, 2651, 23, 17, 25, 3000, 2256, 9679, 1930, 20225, 4284, 2134, 3]}, "items": [{"id": "p_3293", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_3294", "content": "Cocaine [SEP] Cocaine related chest pain: are we seeing the tip of an iceberg?", "tokenized_content": [2, 9045, 3, 9045, 2712, 8475, 3594, 30, 2032, 2038, 23124, 1920, 7933, 1927, 1925, 7133, 7519, 35, 3]}, "items": [{"id": "p_3294", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_3295", "content": "chest pain [SEP] Cocaine related chest pain: are we seeing the tip of an iceberg?", "tokenized_content": [2, 8475, 3594, 3, 9045, 2712, 8475, 3594, 30, 2032, 2038, 23124, 1920, 7933, 1927, 1925, 7133, 7519, 35, 3]}, "items": [{"id": "p_3295", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_3296", "content": "cocaine [SEP] The recreational use of cocaine is on the increase. The emergency nurse ought to be familiar wi", "tokenized_content": [2, 9045, 3, 1920, 21767, 2485, 1927, 9045, 1977, 1990, 1920, 2760, 18, 1920, 7877, 10768, 17208, 2509, 1031, 1942, 1998, 10859, 11980, 3]}, "items": [{"id": "p_3296", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_3297", "content": "chest pain [SEP]  cocaine use. In particular, the tendency of cocaine to produce chest pain ought to be in the mind of the emergency nurse when faced with ", "tokenized_content": [2, 8475, 3594, 3, 9045, 2485, 18, 1922, 3278, 16, 1920, 10080, 1927, 9045, 1942, 5074, 8475, 3594, 17208, 2509, 1031, 1942, 1998, 1922, 1920, 9451, 1927, 1920, 7877, 10768, 2469, 3]}, "items": [{"id": "p_3297", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_3298", "content": "rhabdomyolysis [SEP] Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvast", "tokenized_content": [2, 25369, 6892, 3, 4010, 25369, 6892, 1930, 3939, 4604, 4574, 4067, 1942, 8537, 2485, 1927, 2328, 10916, 1031, 3]}, "items": [{"id": "p_3298", "content": "Rhabdomyolysis [SEP] Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25369, 6892, 3, 7476, 2014, 22398, 1943, 1927, 7345, 3760, 3868, 3489, 2007, 15924, 4365, 17428, 1022, 8754, 18, 3]}]}
{"query": {"id": "q_3299", "content": "acute renal failure [SEP] Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and at", "tokenized_content": [2, 3939, 4604, 4574, 3, 4010, 25369, 6892, 1930, 3939, 4604, 4574, 4067, 1942, 8537, 2485, 1927, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 2019, 3]}, "items": [{"id": "p_3299", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_3300", "content": "simvastatin [SEP] yolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir.", "tokenized_content": [2, 21555, 3, 7419, 27004, 1930, 3939, 4604, 4574, 4067, 1942, 8537, 2485, 1927, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 27382, 12813, 2175, 3026, 18, 3]}, "items": [{"id": "p_3300", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_3301", "content": "amiodarone [SEP] cute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir.", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 4665, 1021, 4604, 4574, 4067, 1942, 8537, 2485, 1927, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 27382, 12813, 2175, 3026, 18, 3]}, "items": [{"id": "p_3301", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_3302", "content": "atazanavir [SEP] re secondary to concomitant use of simvastatin, amiodarone, and atazanavir.", "tokenized_content": [2, 27382, 12813, 2175, 3026, 3, 1964, 4067, 1942, 8537, 2485, 1927, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 27382, 12813, 2175, 3026, 18, 3]}, "items": [{"id": "p_3302", "content": "atazanavir [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 27382, 12813, 2175, 3026, 3, 3]}]}
{"query": {"id": "q_3303", "content": "simvastatin [SEP] OBJECTIVE: To report a case of a severe interaction between simvastatin, amiodarone, and atazanavir resulting in rhabdomyolysis and acu", "tokenized_content": [2, 21555, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 43, 4010, 2835, 2192, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 27382, 12813, 2175, 3026, 3864, 1922, 25369, 6892, 1930, 3]}, "items": [{"id": "p_3303", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_3304", "content": "amiodarone [SEP] : To report a case of a severe interaction between simvastatin, amiodarone, and atazanavir resulting in rhabdomyolysis and acute renal fai", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 30, 1942, 3809, 43, 3087, 1927, 43, 4010, 2835, 2192, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 27382, 12813, 2175, 3026, 3864, 1922, 25369, 3]}, "items": [{"id": "p_3304", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_3305", "content": "atazanavir [SEP] se of a severe interaction between simvastatin, amiodarone, and atazanavir resulting in rhabdomyolysis and acute renal failure. BACKGROUND", "tokenized_content": [2, 27382, 12813, 2175, 3026, 3, 2058, 1927, 43, 4010, 2835, 2192, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 27382, 12813, 2175, 3026, 3864, 1922, 25369, 6892, 1930, 3939, 4604, 3]}, "items": [{"id": "p_3305", "content": "atazanavir [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 27382, 12813, 2175, 3026, 3, 3]}]}
{"query": {"id": "q_3306", "content": "rhabdomyolysis [SEP] on between simvastatin, amiodarone, and atazanavir resulting in rhabdomyolysis and acute renal failure. BACKGROUND: A 72-year-old white man wi", "tokenized_content": [2, 25369, 6892, 3, 1990, 2192, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 27382, 12813, 2175, 3026, 3864, 1922, 25369, 6892, 1930, 3939, 4604, 4574, 18, 3872, 30, 43, 4395, 3]}, "items": [{"id": "p_3306", "content": "Rhabdomyolysis [SEP] Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25369, 6892, 3, 7476, 2014, 22398, 1943, 1927, 7345, 3760, 3868, 3489, 2007, 15924, 4365, 17428, 1022, 8754, 18, 3]}]}
{"query": {"id": "q_3307", "content": "acute renal failure [SEP] tin, amiodarone, and atazanavir resulting in rhabdomyolysis and acute renal failure. BACKGROUND: A 72-year-old white man with underlying human immu", "tokenized_content": [2, 3939, 4604, 4574, 3, 12347, 16, 15665, 25033, 2830, 1021, 16, 1930, 27382, 12813, 2175, 3026, 3864, 1922, 25369, 6892, 1930, 3939, 4604, 4574, 18, 3872, 30, 43, 4395, 17, 3]}, "items": [{"id": "p_3307", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_3308", "content": "human immunodeficiency virus [SEP] al failure. BACKGROUND: A 72-year-old white man with underlying human immunodeficiency virus, atrial fibrillation, coronary artery disease, and hyperlipidem", "tokenized_content": [2, 2616, 13141, 3413, 3, 1969, 4574, 18, 3872, 30, 43, 4395, 17, 2476, 17, 4156, 4511, 2323, 1956, 5030, 2616, 13141, 3413, 16, 9224, 13671, 16, 5846, 5511, 2573, 16, 3]}, "items": [{"id": "p_3308", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_3309", "content": "atrial fibrillation [SEP] ear-old white man with underlying human immunodeficiency virus, atrial fibrillation, coronary artery disease, and hyperlipidemia presented with gen", "tokenized_content": [2, 9224, 13671, 3, 4352, 17, 4156, 4511, 2323, 1956, 5030, 2616, 13141, 3413, 16, 9224, 13671, 16, 5846, 5511, 2573, 16, 1930, 21381, 3549, 1956, 2065, 3]}, "items": [{"id": "p_3309", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_3310", "content": "coronary artery disease [SEP] h underlying human immunodeficiency virus, atrial fibrillation, coronary artery disease, and hyperlipidemia presented with generalized pain, fatigue, a", "tokenized_content": [2, 5846, 5511, 2573, 3, 50, 5030, 2616, 13141, 3413, 16, 9224, 13671, 16, 5846, 5511, 2573, 16, 1930, 21381, 3549, 1956, 9612, 3594, 16, 8656, 16, 43, 3]}, "items": [{"id": "p_3310", "content": "Coronary Artery Disease [SEP] Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerot", "score": 1, "type": null, "tokenized_content": [2, 5846, 5511, 2573, 3, 6598, 4028, 1927, 5846, 9345, 1988, 2278, 13218, 2037, 43, 9901, 14311, 16, 13450, 16, 2014, 2447, 17, 8045, 1991, 3]}]}
{"query": {"id": "q_3311", "content": "hyperlipidemia [SEP] ciency virus, atrial fibrillation, coronary artery disease, and hyperlipidemia presented with generalized pain, fatigue, and dark orange urine", "tokenized_content": [2, 21381, 3, 3371, 2589, 3413, 16, 9224, 13671, 16, 5846, 5511, 2573, 16, 1930, 21381, 3549, 1956, 9612, 3594, 16, 8656, 16, 1930, 6190, 10613, 6960, 3]}, "items": [{"id": "p_3311", "content": "Hyperlipidemias [SEP] Conditions with excess LIPIDS in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21381, 1036, 3, 2961, 1956, 5799, 8238, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_3312", "content": "pain [SEP] y artery disease, and hyperlipidemia presented with generalized pain, fatigue, and dark orange urine for 3 days. The patient was tak", "tokenized_content": [2, 3594, 3, 67, 5511, 2573, 16, 1930, 21381, 3549, 1956, 9612, 3594, 16, 8656, 16, 1930, 6190, 10613, 6960, 1958, 23, 3000, 18, 1920, 2774, 1982, 3393, 3]}, "items": [{"id": "p_3312", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3313", "content": "fatigue [SEP] ry disease, and hyperlipidemia presented with generalized pain, fatigue, and dark orange urine for 3 days. The patient was taking 80 mg", "tokenized_content": [2, 8656, 3, 18650, 2573, 16, 1930, 21381, 3549, 1956, 9612, 3594, 16, 8656, 16, 1930, 6190, 10613, 6960, 1958, 23, 3000, 18, 1920, 2774, 1982, 6303, 3729, 2786, 3]}, "items": [{"id": "p_3313", "content": "Fatigue [SEP] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and re", "score": 1, "type": null, "tokenized_content": [2, 8656, 3, 1920, 3360, 1927, 12615, 8254, 2894, 43, 3047, 1927, 28187, 16, 5018, 2014, 3841, 16, 4378, 2007, 43, 3261, 4796, 1958, 2778, 1930, 1964, 3]}]}
{"query": {"id": "q_3314", "content": "creatine [SEP]  2 years previously). Laboratory evaluation revealed 66,680 U/L creatine kinase, 93 mg/dL blood urea nitrogen, 4.6 mg/dL creatinine, 157", "tokenized_content": [2, 17784, 3, 22, 2739, 3024, 13, 18, 4542, 4391, 3404, 4970, 16, 22120, 63, 19, 54, 17784, 4016, 16, 6156, 2786, 19, 5268, 2877, 10505, 6634, 16, 24, 18, 26, 3]}, "items": [{"id": "p_3314", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_3315", "content": "blood urea nitrogen [SEP] ratory evaluation revealed 66,680 U/L creatine kinase, 93 mg/dL blood urea nitrogen, 4.6 mg/dL creatinine, 1579 U/L aspartate aminotransferase, and", "tokenized_content": [2, 2877, 10505, 6634, 3, 3067, 2247, 4391, 3404, 4970, 16, 22120, 63, 19, 54, 17784, 4016, 16, 6156, 2786, 19, 5268, 2877, 10505, 6634, 16, 24, 18, 26, 2786, 19, 3]}, "items": [{"id": "p_3315", "content": "Blood Urea Nitrogen [SEP] The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% highe", "score": 1, "type": null, "tokenized_content": [2, 2877, 10505, 6634, 3, 1920, 10505, 3110, 1927, 1920, 2877, 9662, 1922, 4430, 1927, 6634, 3919, 18, 3256, 12, 3582, 13, 10505, 6634, 1977, 3993, 2369, 9, 2149, 1021, 3]}]}
{"query": {"id": "q_3316", "content": "creatinine [SEP] 80 U/L creatine kinase, 93 mg/dL blood urea nitrogen, 4.6 mg/dL creatinine, 1579 U/L aspartate aminotransferase, and 738 U/L alanine amino", "tokenized_content": [2, 9374, 3, 3729, 63, 19, 54, 17784, 4016, 16, 6156, 2786, 19, 5268, 2877, 10505, 6634, 16, 24, 18, 26, 2786, 19, 5268, 9374, 16, 14358, 1026, 63, 19, 54, 3]}, "items": [{"id": "p_3316", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_3317", "content": "aspartate [SEP] e, 93 mg/dL blood urea nitrogen, 4.6 mg/dL creatinine, 1579 U/L aspartate aminotransferase, and 738 U/L alanine aminotransferase. Simvast", "tokenized_content": [2, 12878, 3, 47, 16, 6156, 2786, 19, 5268, 2877, 10505, 6634, 16, 24, 18, 26, 2786, 19, 5268, 9374, 16, 14358, 1026, 63, 19, 54, 12878, 15817, 16, 1930, 5356, 3]}, "items": [{"id": "p_3317", "content": "Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca", "score": 1, "type": null, "tokenized_content": [2, 23047, 2687, 3, 2340, 1927, 1920, 2447, 17, 4415, 3835, 4576, 5384, 6966, 1922, 1920, 54, 17, 2386, 18, 2176, 1977, 2435, 1922, 3555, 1930, 4793, 16, 4369, 1922, 9523, 2332, 3]}]}
{"query": {"id": "q_3318", "content": "alanine [SEP] dL creatinine, 1579 U/L aspartate aminotransferase, and 738 U/L alanine aminotransferase. Simvastatin, amiodarone, and the patient's hu", "tokenized_content": [2, 10504, 3, 5268, 9374, 16, 14358, 1026, 63, 19, 54, 12878, 15817, 16, 1930, 5356, 1025, 63, 19, 54, 10504, 15817, 18, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 3]}, "items": [{"id": "p_3318", "content": "Alanine [SEP] A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transaminatio", "score": 1, "type": null, "tokenized_content": [2, 10504, 3, 43, 2447, 17, 4415, 3835, 2687, 1988, 5110, 1922, 2149, 2428, 1922, 2496, 3294, 3360, 1922, 3582, 18, 2176, 1977, 4152, 2037, 11867, 2007, 2127, 3717, 1968, 1037, 3]}]}
{"query": {"id": "q_3319", "content": "Simvastatin [SEP] partate aminotransferase, and 738 U/L alanine aminotransferase. Simvastatin, amiodarone, and the patient's human immunodeficiency virus med", "tokenized_content": [2, 21555, 3, 3131, 2010, 15817, 16, 1930, 5356, 1025, 63, 19, 54, 10504, 15817, 18, 21555, 16, 15665, 25033, 2830, 1021, 16, 1930, 1920, 2774, 11, 61, 2616, 13141, 3413, 3]}, "items": [{"id": "p_3319", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_3320", "content": "Amiodarone [SEP] t simvastatin metabolism. Simvastatin is metabolized by CYP3A4. Amiodarone and atazanavir are recognized CYP3A4 inhibitors. CONCLUSIONS: P", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 62, 21555, 4714, 18, 21555, 1977, 19654, 2007, 20722, 18, 15665, 25033, 2830, 1021, 1930, 27382, 12813, 2175, 3026, 2032, 6783, 20722, 4472, 18, 4355, 3]}, "items": [{"id": "p_3320", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_3321", "content": "statins [SEP]  CYP3A4 inhibitors. CONCLUSIONS: Pharmacokinetic differences in statins are an important consideration for assessing the risk of potent", "tokenized_content": [2, 15511, 3, 20722, 4472, 18, 4355, 30, 12763, 2886, 1922, 15511, 2032, 1925, 2715, 8707, 1958, 7665, 1920, 2565, 1927, 6828, 3]}, "items": [{"id": "p_3321", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_3322", "content": "pravastatin [SEP]  requiring the concurrent use of statins and CYP3A4 inhibitors, pravastatin, fluvastatin, and rosuvastatin carry the lowest risk of drug in", "tokenized_content": [2, 21227, 15337, 3, 8887, 1920, 10391, 2485, 1927, 15511, 1930, 20722, 4472, 16, 21227, 15337, 16, 2848, 15337, 16, 1930, 4742, 12631, 11680, 9875, 1920, 6738, 2565, 1927, 2838, 1922, 3]}, "items": [{"id": "p_3322", "content": "Pravastatin [SEP] An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA ", "score": 1, "type": null, "tokenized_content": [2, 21227, 15337, 3, 1925, 2246, 8257, 4197, 8697, 9483, 3937, 2037, 5054, 1927, 9812, 13047, 5728, 1997, 2688, 6102, 18, 2176, 8016, 1966, 43, 10362, 4106, 1927, 12058, 10027, 3]}]}
{"query": {"id": "q_3323", "content": "fluvastatin [SEP] e concurrent use of statins and CYP3A4 inhibitors, pravastatin, fluvastatin, and rosuvastatin carry the lowest risk of drug interactions; a", "tokenized_content": [2, 2848, 15337, 3, 47, 10391, 2485, 1927, 15511, 1930, 20722, 4472, 16, 21227, 15337, 16, 2848, 15337, 16, 1930, 4742, 12631, 11680, 9875, 1920, 6738, 2565, 1927, 2838, 3719, 31, 3]}, "items": [{"id": "p_3323", "content": "fluvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2848, 15337, 3, 3]}]}
{"query": {"id": "q_3324", "content": "rosuvastatin [SEP] of statins and CYP3A4 inhibitors, pravastatin, fluvastatin, and rosuvastatin carry the lowest risk of drug interactions; atorvastatin carrie", "tokenized_content": [2, 4742, 12631, 11680, 3, 1927, 15511, 1930, 20722, 4472, 16, 21227, 15337, 16, 2848, 15337, 16, 1930, 4742, 12631, 11680, 9875, 1920, 6738, 2565, 1927, 2838, 3719, 31, 23489, 6411, 3]}, "items": [{"id": "p_3324", "content": "rosuvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4742, 12631, 11680, 3, 3]}]}
{"query": {"id": "q_3325", "content": "atorvastatin [SEP] n, and rosuvastatin carry the lowest risk of drug interactions; atorvastatin carries moderate risk, whereas simvastatin and lovastatin have ", "tokenized_content": [2, 23489, 3, 56, 16, 1930, 4742, 12631, 11680, 9875, 1920, 6738, 2565, 1927, 2838, 3719, 31, 23489, 16252, 5086, 2565, 16, 3417, 21555, 1930, 18412, 11680, 2162, 3]}, "items": [{"id": "p_3325", "content": "atorvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23489, 3, 3]}]}
{"query": {"id": "q_3326", "content": "lovastatin [SEP] ns; atorvastatin carries moderate risk, whereas simvastatin and lovastatin have the highest risk and should be avoided in patients taking ", "tokenized_content": [2, 18412, 11680, 3, 4246, 31, 23489, 16252, 5086, 2565, 16, 3417, 21555, 1930, 18412, 11680, 2162, 1920, 4554, 2565, 1930, 3066, 1998, 14329, 1922, 2132, 6303, 3]}, "items": [{"id": "p_3326", "content": "Lovastatin [SEP] A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits", "score": 1, "type": null, "tokenized_content": [2, 18412, 11680, 3, 43, 8697, 9483, 3937, 2037, 5054, 1927, 17604, 11420, 3708, 1036, 18, 1920, 3547, 1977, 43, 6828, 5851, 27971, 2156, 1959, 4913, 5899, 18, 2176, 7042, 3]}]}
{"query": {"id": "q_3327", "content": "vinorelbine [SEP] Phase II trial of vinorelbine in metastatic squamous cell esophageal carcinoma. European Orga", "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 3193, 2890, 3046, 1927, 11132, 28003, 23605, 1021, 1922, 6476, 10364, 2024, 10744, 5373, 18, 6785, 2908, 1019, 3]}, "items": [{"id": "p_3327", "content": "vinorelbine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 3]}]}
{"query": {"id": "q_3328", "content": "squamous cell esophageal carcinoma [SEP] Phase II trial of vinorelbine in metastatic squamous cell esophageal carcinoma. European Organization for Research and Treatment of Cancer Gas", "tokenized_content": [2, 10364, 2024, 10744, 5373, 3, 3193, 2890, 3046, 1927, 11132, 28003, 23605, 1021, 1922, 6476, 10364, 2024, 10744, 5373, 18, 6785, 5901, 1958, 2659, 1930, 2311, 1927, 2539, 4422, 3]}, "items": [{"id": "p_3328", "content": "Esophageal Squamous Cell Carcinoma [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10744, 10364, 2024, 5373, 3, 3]}]}
{"query": {"id": "q_3329", "content": "Cancer [SEP]  carcinoma. European Organization for Research and Treatment of Cancer Gastrointestinal Treat Cancer Cooperative Group.", "tokenized_content": [2, 2539, 3, 5373, 18, 6785, 5901, 1958, 2659, 1930, 2311, 1927, 2539, 8375, 2297, 2539, 13350, 2210, 18, 3]}, "items": [{"id": "p_3329", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3330", "content": "vinorelbine [SEP] PURPOSE: To evaluate the response rate and toxic effects of vinorelbine (VNB) administered as a single agent in metastatic squamous cel", "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 5120, 30, 1942, 4323, 1920, 2644, 2769, 1930, 6161, 2564, 1927, 11132, 28003, 23605, 1021, 12, 18155, 1014, 13, 5254, 1966, 43, 2957, 5899, 1922, 3]}, "items": [{"id": "p_3330", "content": "vinorelbine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 3]}]}
{"query": {"id": "q_3331", "content": "VNB [SEP] To evaluate the response rate and toxic effects of vinorelbine (VNB) administered as a single agent in metastatic squamous cell eso", "tokenized_content": [2, 18155, 1014, 3, 1942, 4323, 1920, 2644, 2769, 1930, 6161, 2564, 1927, 11132, 28003, 23605, 1021, 12, 18155, 1014, 13, 5254, 1966, 43, 2957, 5899, 1922, 6476, 10364, 2024, 2376, 3]}, "items": [{"id": "p_3331", "content": "vinorelbine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11132, 28003, 23605, 1021, 3, 3]}]}
{"query": {"id": "q_3332", "content": "squamous cell esophageal carcinoma [SEP]  vinorelbine (VNB) administered as a single agent in metastatic squamous cell esophageal carcinoma. PATIENTS AND METHODS: Forty-six eligible patients with measura", "tokenized_content": [2, 10364, 2024, 10744, 5373, 3, 11132, 28003, 23605, 1021, 12, 18155, 1014, 13, 5254, 1966, 43, 2957, 5899, 1922, 6476, 10364, 2024, 10744, 5373, 18, 2132, 1930, 2860, 30, 11270, 3]}, "items": [{"id": "p_3332", "content": "Esophageal Squamous Cell Carcinoma [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10744, 10364, 2024, 5373, 3, 3]}]}
{"query": {"id": "q_3333", "content": "cisplatin [SEP] irty patients without prior chemotherapy and 16 pretreated with cisplatin-based chemotherapy were assessable for toxicity and response. V", "tokenized_content": [2, 9284, 3, 3166, 3145, 2132, 2979, 3432, 5318, 1930, 2641, 12152, 1956, 9284, 17, 2454, 5318, 1985, 2634, 2115, 1958, 5532, 1930, 2644, 18, 64, 3]}, "items": [{"id": "p_3333", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3334", "content": "toxicity [SEP] retreated with cisplatin-based chemotherapy were assessable for toxicity and response. VNB was administered weekly as a 25-mg/m2 short i", "tokenized_content": [2, 5532, 3, 6415, 5376, 2013, 1956, 9284, 17, 2454, 5318, 1985, 2634, 2115, 1958, 5532, 1930, 2644, 18, 18155, 1014, 1982, 5254, 9628, 1966, 43, 2637, 17, 2786, 19, 6056, 3]}, "items": [{"id": "p_3334", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3335", "content": "granulocytopenia [SEP] tologic toxicity occurred. At least one episode of grade 3 or 4 granulocytopenia was seen in 59% of patients. A grade 2 or 3 infection occurred ", "tokenized_content": [2, 9015, 3107, 12903, 3, 21930, 2021, 1935, 5532, 4807, 18, 2019, 3464, 2340, 11631, 1927, 4927, 23, 2014, 24, 9015, 3107, 12903, 1982, 3945, 1922, 4777, 9, 1927, 2132, 18, 3]}, "items": [{"id": "p_3335", "content": "Agranulocytosis [SEP] A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 23171, 1928, 1944, 7349, 3, 43, 3714, 1922, 1920, 2529, 1927, 22144, 31, 12, 29929, 31, 15854, 31, 1930, 8508, 13, 18, 3]}]}
{"query": {"id": "q_3336", "content": "infection [SEP]  4 granulocytopenia was seen in 59% of patients. A grade 2 or 3 infection occurred in 16% of patients, but no toxic deaths occurred. Othe", "tokenized_content": [2, 2909, 3, 24, 9015, 3107, 12903, 1982, 3945, 1922, 4777, 9, 1927, 2132, 18, 43, 4927, 22, 2014, 23, 2909, 4807, 1922, 2641, 9, 1927, 2132, 16, 2308, 2239, 6161, 3]}, "items": [{"id": "p_3336", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_3337", "content": "deaths [SEP] rade 2 or 3 infection occurred in 16% of patients, but no toxic deaths occurred. Other side effects were rare, and peripheral neurotox", "tokenized_content": [2, 7601, 3, 4226, 1021, 22, 2014, 23, 2909, 4807, 1922, 2641, 9, 1927, 2132, 16, 2308, 2239, 6161, 7601, 4807, 18, 2303, 4159, 2564, 1985, 5844, 16, 1930, 5009, 9124, 3]}, "items": [{"id": "p_3337", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_3338", "content": "peripheral neurotoxicity [SEP] but no toxic deaths occurred. Other side effects were rare, and peripheral neurotoxicity has been minor (26% grade 1). CONCLUSION: These data indicate t", "tokenized_content": [2, 5009, 18034, 3, 2308, 2239, 6161, 7601, 4807, 18, 2303, 4159, 2564, 1985, 5844, 16, 1930, 5009, 18034, 2258, 2252, 5857, 12, 3179, 9, 4927, 21, 13, 18, 4180, 30, 3]}, "items": [{"id": "p_3338", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_3339", "content": "esophageal squamous cell carcinoma [SEP] : These data indicate that VNB is an active agent in metastatic esophageal squamous cell carcinoma. Given its excellent tolerance profile and low toxicity, furthe", "tokenized_content": [2, 10744, 10364, 2024, 5373, 3, 30, 2144, 2230, 3579, 1988, 18155, 1014, 1977, 1925, 3500, 5899, 1922, 6476, 10744, 10364, 2024, 5373, 18, 3258, 2496, 7526, 6555, 5174, 1930, 2330, 3]}, "items": [{"id": "p_3339", "content": "Esophageal Squamous Cell Carcinoma [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10744, 10364, 2024, 5373, 3, 3]}]}
{"query": {"id": "q_3340", "content": "Paclitaxel [SEP] Paclitaxel, cisplatin, and gemcitabine combination chemotherapy within a m", "tokenized_content": [2, 12404, 3, 12404, 16, 9284, 16, 1930, 15696, 3921, 5318, 2651, 43, 55, 3]}, "items": [{"id": "p_3340", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_3341", "content": "cisplatin [SEP] Paclitaxel, cisplatin, and gemcitabine combination chemotherapy within a multidiscipl", "tokenized_content": [2, 9284, 3, 12404, 16, 9284, 16, 1930, 15696, 3921, 5318, 2651, 43, 9184, 11760, 2030, 3]}, "items": [{"id": "p_3341", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3342", "content": "gemcitabine [SEP] Paclitaxel, cisplatin, and gemcitabine combination chemotherapy within a multidisciplinary therapeutic", "tokenized_content": [2, 15696, 3, 12404, 16, 9284, 16, 1930, 15696, 3921, 5318, 2651, 43, 15094, 4272, 3]}, "items": [{"id": "p_3342", "content": "gemcitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15696, 3, 3]}]}
{"query": {"id": "q_3343", "content": "nonsmall cell lung carcinoma [SEP] y within a multidisciplinary therapeutic approach in metastatic nonsmall cell lung carcinoma.", "tokenized_content": [2, 22525, 2214, 2024, 3614, 5373, 3, 67, 2651, 43, 15094, 4272, 2998, 1922, 6476, 22525, 2214, 2024, 3614, 5373, 18, 3]}, "items": [{"id": "p_3343", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_3344", "content": "Cisplatin [SEP] BACKGROUND: Cisplatin-based chemotherapy combinations improve quality of life and sur", "tokenized_content": [2, 9284, 3, 3872, 30, 9284, 17, 2454, 5318, 7763, 3326, 3455, 1927, 3308, 1930, 2250, 3]}, "items": [{"id": "p_3344", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3345", "content": "nonsmall cell lung carcinoma [SEP] y combinations improve quality of life and survival in advanced nonsmall cell lung carcinoma (NSCLC). The emergence of new active drugs might translate into", "tokenized_content": [2, 22525, 2214, 2024, 3614, 5373, 3, 67, 7763, 3326, 3455, 1927, 3308, 1930, 3298, 1922, 5570, 22525, 2214, 2024, 3614, 5373, 12, 9298, 13, 18, 1920, 10400, 1927, 2814, 3500, 3]}, "items": [{"id": "p_3345", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_3346", "content": "NSCLC [SEP]  of life and survival in advanced nonsmall cell lung carcinoma (NSCLC). The emergence of new active drugs might translate into more e", "tokenized_content": [2, 9298, 3, 1927, 3308, 1930, 3298, 1922, 5570, 22525, 2214, 2024, 3614, 5373, 12, 9298, 13, 18, 1920, 10400, 1927, 2814, 3500, 4195, 3284, 16767, 2460, 2253, 47, 3]}, "items": [{"id": "p_3346", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_3347", "content": "toxicity [SEP] this study was to determine the feasibility, response rate, and toxicity of a paclitaxel, cisplatin, and gemcitabine combination to trea", "tokenized_content": [2, 5532, 3, 2052, 2161, 1982, 1942, 3415, 1920, 10067, 16, 2644, 2769, 16, 1930, 5532, 1927, 43, 12404, 16, 9284, 16, 1930, 15696, 3921, 1942, 2171, 1019, 3]}, "items": [{"id": "p_3347", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3348", "content": "paclitaxel [SEP]  to determine the feasibility, response rate, and toxicity of a paclitaxel, cisplatin, and gemcitabine combination to treat metastatic NSC", "tokenized_content": [2, 12404, 3, 1942, 3415, 1920, 10067, 16, 2644, 2769, 16, 1930, 5532, 1927, 43, 12404, 16, 9284, 16, 1930, 15696, 3921, 1942, 2297, 6476, 18438, 3]}, "items": [{"id": "p_3348", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_3349", "content": "cisplatin [SEP] e the feasibility, response rate, and toxicity of a paclitaxel, cisplatin, and gemcitabine combination to treat metastatic NSCLC. Thirty-", "tokenized_content": [2, 9284, 3, 47, 1920, 10067, 16, 2644, 2769, 16, 1930, 5532, 1927, 43, 12404, 16, 9284, 16, 1930, 15696, 3921, 1942, 2297, 6476, 9298, 18, 9942, 17, 3]}, "items": [{"id": "p_3349", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3350", "content": "gemcitabine [SEP] ty, response rate, and toxicity of a paclitaxel, cisplatin, and gemcitabine combination to treat metastatic NSCLC. Thirty-five consecutive ", "tokenized_content": [2, 15696, 3, 6227, 16, 2644, 2769, 16, 1930, 5532, 1927, 43, 12404, 16, 9284, 16, 1930, 15696, 3921, 1942, 2297, 6476, 9298, 18, 9942, 17, 3628, 7351, 3]}, "items": [{"id": "p_3350", "content": "gemcitabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15696, 3, 3]}]}
{"query": {"id": "q_3351", "content": "neutropenia [SEP] 2) for gemcitabine (86.2%). World Health Organization Grade 3-4 neutropenia and thrombocytopenia occurred in 39.9% and 11.4% of patients, r", "tokenized_content": [2, 18005, 3, 22, 13, 1958, 15696, 12, 5713, 18, 22, 9, 13, 18, 4867, 2436, 5901, 4927, 23, 17, 24, 18005, 1930, 17100, 4807, 1922, 3886, 18, 29, 9, 1930, 3]}, "items": [{"id": "p_3351", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_3352", "content": "thrombocytopenia [SEP] ne (86.2%). World Health Organization Grade 3-4 neutropenia and thrombocytopenia occurred in 39.9% and 11.4% of patients, respectively. There wa", "tokenized_content": [2, 17100, 3, 2069, 12, 5713, 18, 22, 9, 13, 18, 4867, 2436, 5901, 4927, 23, 17, 24, 18005, 1930, 17100, 4807, 1922, 3886, 18, 29, 9, 1930, 2513, 18, 24, 3]}, "items": [{"id": "p_3352", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_3353", "content": "death [SEP] 1.4% of patients, respectively. There was one treatment-related death. Nonhematologic toxicities were mild. After a median follow-up ", "tokenized_content": [2, 3539, 3, 21, 18, 24, 9, 1927, 2132, 16, 2763, 18, 2276, 1982, 2340, 2311, 17, 2712, 3539, 18, 16925, 9900, 4467, 15251, 1985, 5809, 18, 2256, 43, 4181, 2396, 3]}, "items": [{"id": "p_3353", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_3354", "content": "toxicities [SEP] ectively. There was one treatment-related death. Nonhematologic toxicities were mild. After a median follow-up of 22 months, the median pr", "tokenized_content": [2, 15251, 3, 7495, 5102, 18, 2276, 1982, 2340, 2311, 17, 2712, 3539, 18, 16925, 9900, 4467, 15251, 1985, 5809, 18, 2256, 43, 4181, 2396, 17, 2353, 1927, 2950, 3221, 16, 3]}, "items": [{"id": "p_3354", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3355", "content": "aponidine hydrochloride [SEP] Evaluation of adverse reactions of aponidine hydrochloride ophthalmic solution.", "tokenized_content": [2, 11466, 8635, 27099, 16675, 3, 4391, 1927, 5246, 5298, 1927, 11466, 8635, 27099, 16675, 21421, 3331, 18, 3]}, "items": [{"id": "p_3355", "content": "apraclonidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9463, 5095, 13339, 27099, 3, 3]}]}
{"query": {"id": "q_3356", "content": "apraclonidine [SEP] We prospectively evaluated the adverse reactions of apraclonidine in 20 normal volunteers by instilling a single drop of 1% aprac", "tokenized_content": [2, 9463, 5095, 13339, 27099, 3, 2038, 12439, 3747, 1920, 5246, 5298, 1927, 9463, 5095, 13339, 27099, 1922, 2036, 2791, 9701, 2007, 4766, 7517, 43, 2957, 7086, 1927, 21, 9, 9463, 3]}, "items": [{"id": "p_3356", "content": "apraclonidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9463, 5095, 13339, 27099, 3, 3]}]}
{"query": {"id": "q_3357", "content": "ocular hypotensive [SEP] ior to entry and at 1, 3, 5 and 7 hours after instillation. The ocular hypotensive effects were statistically significant for apraclonidine-treate", "tokenized_content": [2, 10046, 12201, 3766, 3, 21509, 1005, 1942, 6904, 1930, 2019, 21, 16, 23, 16, 25, 1930, 27, 3967, 2256, 24893, 18, 1920, 10046, 12201, 3766, 2564, 1985, 4388, 2228, 1958, 3]}, "items": [{"id": "p_3357", "content": "Ocular Hypotension [SEP] Abnormally low intraocular pressure often related to chronic inflammation (uveitis).\n    ", "score": 1, "type": null, "tokenized_content": [2, 10046, 16453, 3, 20756, 2330, 17258, 3772, 3868, 2712, 1942, 3724, 4531, 12, 22140, 13, 18, 3]}]}
{"query": {"id": "q_3358", "content": "Decreases in systolic blood pressure [SEP] m three hours after topical administration of 1% apraclonidine. Decreases in systolic blood pressure were statistically, but not clinically, significant. No signifi", "tokenized_content": [2, 6386, 1922, 8541, 2877, 3772, 3, 55, 2559, 3967, 2256, 12259, 4183, 1927, 21, 9, 9463, 5095, 13339, 27099, 18, 6386, 1922, 8541, 2877, 3772, 1985, 4388, 16, 2308, 2084, 3]}, "items": [{"id": "p_3358", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3359", "content": "Conjunctival blanching [SEP] blood pressure, pulse rate and basal tear secretion were noted. Conjunctival blanching and mydriasis were commonly found. Upper lid retraction was fre", "tokenized_content": [2, 23702, 18208, 15895, 7969, 2029, 3, 2877, 3772, 16, 7110, 2769, 1930, 5342, 12650, 5512, 1985, 5040, 18, 23702, 18208, 15895, 7969, 2029, 1930, 15388, 3027, 3932, 1985, 5384, 2435, 3]}, "items": [{"id": "p_3359", "content": "Conjunctival Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23702, 3902, 3, 3]}]}
{"query": {"id": "q_3360", "content": "mydriasis [SEP] and basal tear secretion were noted. Conjunctival blanching and mydriasis were commonly found. Upper lid retraction was frequently noted.", "tokenized_content": [2, 15388, 3027, 3932, 3, 1930, 5342, 12650, 5512, 1985, 5040, 18, 23702, 18208, 15895, 7969, 2029, 1930, 15388, 3027, 3932, 1985, 5384, 2435, 18, 5199, 13096, 20629, 1982, 5467, 5040, 3]}, "items": [{"id": "p_3360", "content": "Mydriasis [SEP] Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condit", "score": 1, "type": null, "tokenized_content": [2, 15388, 3027, 3932, 3, 16470, 1927, 29697, 1942, 3430, 2254, 26, 2489, 4252, 1956, 4574, 1927, 1920, 29697, 1942, 15595, 1031, 2469, 5449, 1956, 3696, 18, 2052, 8646, 1932, 3]}]}
{"query": {"id": "q_3361", "content": "entropion [SEP] able change in appearance, one subject suffered from mechanical entropion and marked corneal abrasion 3 hours after instillation of the m", "tokenized_content": [2, 12883, 2001, 3, 4236, 3185, 1922, 7818, 16, 2340, 5198, 13949, 2037, 5821, 12883, 2001, 1930, 4961, 9990, 16746, 19639, 23, 3967, 2256, 24893, 1927, 1920, 55, 3]}, "items": [{"id": "p_3361", "content": "Entropion [SEP] The turning inward (inversion) of the edge of the eyelid, with the tarsal cartilage turned inward toward the eyeball. (Dorland, ", "score": 1, "type": null, "tokenized_content": [2, 12883, 2001, 3, 1920, 18678, 16998, 12, 14825, 13, 1927, 1920, 8269, 1927, 1920, 25619, 16, 1956, 1920, 25067, 1923, 8642, 14031, 16998, 4205, 1920, 5723, 16344, 18, 12, 19638, 4702, 16, 3]}]}
{"query": {"id": "q_3362", "content": "corneal abrasion [SEP] ance, one subject suffered from mechanical entropion and marked corneal abrasion 3 hours after instillation of the medication. This may well be ", "tokenized_content": [2, 9990, 16746, 19639, 3, 10315, 1021, 16, 2340, 5198, 13949, 2037, 5821, 12883, 2001, 1930, 4961, 9990, 16746, 19639, 23, 3967, 2256, 24893, 1927, 1920, 6093, 18, 2052, 2278, 2486, 3]}, "items": [{"id": "p_3362", "content": "Corneal Diseases [SEP] Diseases of the cornea.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9990, 3902, 3, 3902, 1927, 1920, 16678, 18, 3]}]}
{"query": {"id": "q_3363", "content": "Carmofur [SEP] Carmofur-induced organic mental disorders.", "tokenized_content": [2, 2279, 12492, 19073, 1005, 3, 2279, 12492, 19073, 1005, 17, 2719, 6805, 5018, 4414, 18, 3]}, "items": [{"id": "p_3363", "content": "1-hexylcarbamoyl-5-fluorouracil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 7142, 2199, 15339, 7972, 12492, 2199, 17, 25, 17, 21353, 3, 3]}]}
{"query": {"id": "q_3364", "content": "organic mental disorders [SEP] Carmofur-induced organic mental disorders.", "tokenized_content": [2, 6805, 5018, 4414, 3, 2279, 12492, 19073, 1005, 17, 2719, 6805, 5018, 4414, 18, 3]}, "items": [{"id": "p_3364", "content": "Delirium, Dementia, Amnestic, Cognitive Disorders [SEP] Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, traum", "score": 1, "type": null, "tokenized_content": [2, 18166, 16, 7811, 16, 14701, 8396, 16, 4328, 4414, 3, 4328, 4414, 2710, 18166, 16, 7811, 16, 1930, 2303, 4328, 4414, 18, 2144, 2278, 1998, 1920, 3211, 1927, 7311, 2485, 16, 5832, 3]}]}
{"query": {"id": "q_3365", "content": "Organic mental disorder [SEP] Organic mental disorder was observed in a 29-year-old female in the prognostic period a", "tokenized_content": [2, 6805, 5018, 4770, 3, 6805, 5018, 4770, 1982, 2528, 1922, 43, 3230, 17, 2476, 17, 4156, 4232, 1922, 1920, 6750, 3047, 43, 3]}, "items": [{"id": "p_3365", "content": "Delirium, Dementia, Amnestic, Cognitive Disorders [SEP] Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, traum", "score": 1, "type": null, "tokenized_content": [2, 18166, 16, 7811, 16, 14701, 8396, 16, 4328, 4414, 3, 4328, 4414, 2710, 18166, 16, 7811, 16, 1930, 2303, 4328, 4414, 18, 2144, 2278, 1998, 1920, 3211, 1927, 7311, 2485, 16, 5832, 3]}]}
{"query": {"id": "q_3366", "content": "carmofur [SEP]  29-year-old female in the prognostic period after the onset of carmofur-induced leukoencephalopathy. Symptoms such as euphoria, emotion", "tokenized_content": [2, 2279, 12492, 19073, 1005, 3, 3230, 17, 2476, 17, 4156, 4232, 1922, 1920, 6750, 3047, 2256, 1920, 4727, 1927, 2279, 12492, 19073, 1005, 17, 2719, 5104, 29159, 6522, 18, 3601, 3]}, "items": [{"id": "p_3366", "content": "1-hexylcarbamoyl-5-fluorouracil [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 7142, 2199, 15339, 7972, 12492, 2199, 17, 25, 17, 21353, 3, 3]}]}
{"query": {"id": "q_3367", "content": "leukoencephalopathy [SEP] le in the prognostic period after the onset of carmofur-induced leukoencephalopathy. Symptoms such as euphoria, emotional lability and puerile atti", "tokenized_content": [2, 5104, 29159, 6522, 3, 2071, 1922, 1920, 6750, 3047, 2256, 1920, 4727, 1927, 2279, 12492, 19073, 1005, 17, 2719, 5104, 29159, 6522, 18, 3601, 2427, 1966, 4791, 2102, 26577, 16, 3]}, "items": [{"id": "p_3367", "content": "Leukoencephalopathies [SEP] Any of various diseases affecting the white matter of the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5104, 29159, 16038, 3, 2967, 1927, 3425, 3902, 7359, 1920, 4511, 6537, 1927, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_3368", "content": "organic personality syndrome [SEP] ity and puerile attitude noted in the patient were diagnosed as organic personality syndrome according to the criteria defined in the DSM-III-R. It is refer", "tokenized_content": [2, 6805, 10111, 4741, 3, 2176, 1012, 1930, 6612, 18842, 1952, 14204, 5040, 1922, 1920, 2774, 1985, 5377, 1966, 6805, 10111, 4741, 3147, 1942, 1920, 4164, 3608, 1922, 1920, 10964, 17, 3]}, "items": [{"id": "p_3368", "content": "Personality Disorders [SEP] A major deviation from normal patterns of behavior.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10111, 4414, 3, 43, 3044, 6015, 2037, 2791, 4147, 1927, 3379, 18, 3]}]}
{"query": {"id": "q_3369", "content": "frontal lobe syndrome [SEP] o the criteria defined in the DSM-III-R. It is referred to as a frontal lobe syndrome. Brain CT revealed a periventricular low density area in the fr", "tokenized_content": [2, 8086, 9581, 4741, 3, 57, 1920, 4164, 3608, 1922, 1920, 10964, 17, 4337, 17, 60, 18, 2176, 1977, 6656, 1942, 1966, 43, 8086, 9581, 4741, 18, 3068, 3369, 3404, 43, 3]}, "items": [{"id": "p_3369", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3370", "content": "structural damage to the frontal lobe [SEP] ity syndrome in the residual state. It may be attributed to the structural damage to the frontal lobe.", "tokenized_content": [2, 4346, 4293, 1942, 1920, 8086, 9581, 3, 2176, 1012, 4741, 1922, 1920, 6615, 3360, 18, 2176, 2278, 1998, 6898, 1942, 1920, 4346, 4293, 1942, 1920, 8086, 9581, 18, 3]}, "items": [{"id": "p_3370", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3371", "content": "mexiletine [SEP] International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhyth", "tokenized_content": [2, 10114, 2383, 4425, 3, 6019, 10114, 2383, 4425, 1930, 5936, 2246, 23246, 4913, 5846, 3046, 30, 51, 18, 3809, 1990, 11335, 3]}, "items": [{"id": "p_3371", "content": "Mexiletine [SEP] Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10114, 2383, 4425, 3, 2246, 23246, 4913, 5899, 24645, 2551, 1942, 19567, 18, 2176, 2278, 2162, 2673, 26572, 2031, 3879, 18, 3]}]}
{"query": {"id": "q_3372", "content": "arrhythmia [SEP] iletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group.", "tokenized_content": [2, 18346, 3, 9940, 4425, 1930, 5936, 2246, 23246, 4913, 5846, 3046, 30, 51, 18, 3809, 1990, 18346, 1930, 2303, 3056, 18, 3829, 2659, 2210, 18, 3]}, "items": [{"id": "p_3372", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_3373", "content": "mexiletine [SEP] The antiarrhythmic effects of the sustained release form of mexiletine (Mexitil-Perlongets) were evaluated in a double-blind placebo t", "tokenized_content": [2, 10114, 2383, 4425, 3, 1920, 2246, 23246, 4913, 2564, 1927, 1920, 7637, 4012, 2386, 1927, 10114, 2383, 4425, 12, 10114, 2078, 1024, 17, 24796, 18771, 1973, 13, 1985, 3747, 1922, 3]}, "items": [{"id": "p_3373", "content": "Mexiletine [SEP] Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10114, 2383, 4425, 3, 2246, 23246, 4913, 5899, 24645, 2551, 1942, 19567, 18, 2176, 2278, 2162, 2673, 26572, 2031, 3879, 18, 3]}]}
{"query": {"id": "q_3374", "content": "Mexitil-Perlongets [SEP] arrhythmic effects of the sustained release form of mexiletine (Mexitil-Perlongets) were evaluated in a double-blind placebo trial in 630 patients", "tokenized_content": [2, 10114, 2078, 1024, 17, 24796, 18771, 1973, 3, 11335, 4913, 2564, 1927, 1920, 7637, 4012, 2386, 1927, 10114, 2383, 4425, 12, 10114, 2078, 1024, 17, 24796, 18771, 1973, 13, 1985, 3]}, "items": [{"id": "p_3374", "content": "Mexiletine [SEP] Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10114, 2383, 4425, 3, 2246, 23246, 4913, 5899, 24645, 2551, 1942, 19567, 18, 2176, 2278, 2162, 2673, 26572, 2031, 3879, 18, 3]}]}
{"query": {"id": "q_3375", "content": "myocardial infarction [SEP] uble-blind placebo trial in 630 patients with recent documented myocardial infarction. The primary response variable was based on central reading of ", "tokenized_content": [2, 6497, 8358, 3, 4803, 1952, 17, 7109, 5936, 3046, 1922, 22884, 2132, 1956, 3505, 6974, 6497, 8358, 18, 1920, 3065, 2644, 4650, 1982, 2454, 1990, 4101, 7461, 1927, 3]}, "items": [{"id": "p_3375", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_3376", "content": "deaths [SEP] es that have used the regular form of the drug. There were more deaths in the mexiletine group (7.6%) than in the placebo group (4.8%)", "tokenized_content": [2, 7601, 3, 2376, 1988, 2162, 2251, 1920, 6314, 2386, 1927, 1920, 2838, 18, 2276, 1985, 2253, 7601, 1922, 1920, 10114, 2383, 4425, 2210, 12, 27, 18, 26, 9, 13, 2254, 3]}, "items": [{"id": "p_3376", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_3377", "content": "tremor [SEP] n both groups. Previously recognized side effects, particularly tremor and gastrointestinal problems, were more frequent in the mexile", "tokenized_content": [2, 18388, 3, 56, 2321, 2671, 18, 3024, 6783, 4159, 2564, 16, 4443, 18388, 1930, 8375, 4951, 16, 1985, 2253, 6439, 1922, 1920, 10114, 2383, 3]}, "items": [{"id": "p_3377", "content": "Tremor [SEP] Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or act", "score": 1, "type": null, "tokenized_content": [2, 18388, 3, 9821, 1923, 5829, 1927, 43, 3362, 3131, 1988, 2112, 3015, 3108, 43, 13900, 2585, 2014, 43, 15570, 1927, 2573, 18, 10298, 2014, 4033, 3]}]}
{"query": {"id": "q_3378", "content": "gastrointestinal problems [SEP] ps. Previously recognized side effects, particularly tremor and gastrointestinal problems, were more frequent in the mexiletine group than in the placebo", "tokenized_content": [2, 8375, 4951, 3, 2742, 18, 3024, 6783, 4159, 2564, 16, 4443, 18388, 1930, 8375, 4951, 16, 1985, 2253, 6439, 1922, 1920, 10114, 2383, 4425, 2210, 2254, 1922, 1920, 5936, 3]}, "items": [{"id": "p_3378", "content": "Signs and Symptoms, Digestive [SEP] Digestive system manifestations of diseases of the gastrointestinal system or of other organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6879, 1930, 3601, 16, 15486, 3, 15486, 2433, 10952, 1927, 3902, 1927, 1920, 8375, 2433, 2014, 1927, 2303, 7393, 18, 3]}]}
{"query": {"id": "q_3379", "content": "amphetamine [SEP] Regional localization of the antagonism of amphetamine-induced hyperactivity by intracerebral calcitonin injections.", "tokenized_content": [2, 19057, 3, 6937, 5363, 1927, 1920, 18394, 1927, 19057, 17, 2719, 15534, 2007, 24152, 26406, 8775, 18, 3]}, "items": [{"id": "p_3379", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_3380", "content": "hyperactivity [SEP] Regional localization of the antagonism of amphetamine-induced hyperactivity by intracerebral calcitonin injections.", "tokenized_content": [2, 15534, 3, 6937, 5363, 1927, 1920, 18394, 1927, 19057, 17, 2719, 15534, 2007, 24152, 26406, 8775, 18, 3]}, "items": [{"id": "p_3380", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_3381", "content": "calcitonin [SEP] ntagonism of amphetamine-induced hyperactivity by intracerebral calcitonin injections.", "tokenized_content": [2, 26406, 3, 20503, 3827, 11110, 1035, 1927, 19057, 17, 2719, 15534, 2007, 24152, 26406, 8775, 18, 3]}, "items": [{"id": "p_3381", "content": "Calcitonin [SEP] A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decreas", "score": 1, "type": null, "tokenized_content": [2, 26406, 3, 43, 4207, 6365, 1988, 25617, 5016, 3110, 1922, 1920, 2877, 18, 1922, 5209, 16, 2176, 1977, 6988, 2007, 6918, 2094, 1930, 8016, 1942, 2649, 1934, 3]}]}
{"query": {"id": "q_3382", "content": "Calcitonin [SEP] Calcitonin receptors are found in the brain, and intracerebral infusions o", "tokenized_content": [2, 26406, 3, 26406, 4086, 2032, 2435, 1922, 1920, 3068, 16, 1930, 24152, 17656, 57, 3]}, "items": [{"id": "p_3382", "content": "Calcitonin [SEP] A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decreas", "score": 1, "type": null, "tokenized_content": [2, 26406, 3, 43, 4207, 6365, 1988, 25617, 5016, 3110, 1922, 1920, 2877, 18, 1922, 5209, 16, 2176, 1977, 6988, 2007, 6918, 2094, 1930, 8016, 1942, 2649, 1934, 3]}]}
{"query": {"id": "q_3383", "content": "calcitonin [SEP] eceptors are found in the brain, and intracerebral infusions of calcitonin can produce behavioral effects. Among these behavioral effects ", "tokenized_content": [2, 26406, 3, 3270, 7344, 2133, 2032, 2435, 1922, 1920, 3068, 16, 1930, 24152, 17656, 1927, 26406, 2112, 5074, 5343, 2564, 18, 2706, 2144, 5343, 2564, 3]}, "items": [{"id": "p_3383", "content": "Calcitonin [SEP] A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decreas", "score": 1, "type": null, "tokenized_content": [2, 26406, 3, 43, 4207, 6365, 1988, 25617, 5016, 3110, 1922, 1920, 2877, 18, 1922, 5209, 16, 2176, 1977, 6988, 2007, 6918, 2094, 1930, 8016, 1942, 2649, 1934, 3]}]}
{"query": {"id": "q_3384", "content": "amphetamine [SEP] ehavioral effects are decreases in food intake and decreases in amphetamine-induced locomotor activity. In previous experiments we found th", "tokenized_content": [2, 19057, 3, 12429, 9188, 6277, 2564, 2032, 6386, 1922, 3959, 5240, 1930, 6386, 1922, 19057, 17, 2719, 13594, 2455, 18, 1922, 2555, 3144, 2038, 2435, 1913, 3]}, "items": [{"id": "p_3384", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_3385", "content": "intracranial bleeding [SEP] Fatal intracranial bleeding associated with prehospital use of epinephrine.", "tokenized_content": [2, 12179, 7633, 3, 11990, 12179, 7633, 2458, 1956, 21161, 21605, 2485, 1927, 19280, 18, 3]}, "items": [{"id": "p_3385", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_3386", "content": "epinephrine [SEP] Fatal intracranial bleeding associated with prehospital use of epinephrine.", "tokenized_content": [2, 19280, 3, 11990, 12179, 7633, 2458, 1956, 21161, 21605, 2485, 1927, 19280, 18, 3]}, "items": [{"id": "p_3386", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_3387", "content": "allergic reaction [SEP] misjudgment in the execution of a protocol for the treatment of allergic reaction in a case of pulmonary edema with wheezing. The sudden onset of", "tokenized_content": [2, 10519, 3227, 3, 5682, 29985, 18266, 1939, 1922, 1920, 15494, 1927, 43, 4478, 1958, 1920, 2311, 1927, 10519, 3227, 1922, 43, 3087, 1927, 5352, 10144, 1956, 28035, 18, 1920, 12446, 3]}, "items": [{"id": "p_3387", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_3388", "content": "pulmonary edema [SEP]  a protocol for the treatment of allergic reaction in a case of pulmonary edema with wheezing. The sudden onset of respiratory distress, rash, ", "tokenized_content": [2, 5352, 10144, 3, 43, 4478, 1958, 1920, 2311, 1927, 10519, 3227, 1922, 43, 3087, 1927, 5352, 10144, 1956, 28035, 18, 1920, 12446, 4727, 1927, 5481, 8740, 16, 18469, 16, 3]}, "items": [{"id": "p_3388", "content": "Pulmonary Edema [SEP] Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary ", "score": 1, "type": null, "tokenized_content": [2, 5352, 10144, 3, 9122, 4858, 1927, 21263, 18021, 5148, 1005, 5466, 1922, 1920, 3614, 16, 1925, 10331, 1927, 43, 7433, 5030, 2573, 2014, 4770, 18, 5352, 3]}]}
{"query": {"id": "q_3389", "content": "wheezing [SEP] reatment of allergic reaction in a case of pulmonary edema with wheezing. The sudden onset of respiratory distress, rash, and a history ", "tokenized_content": [2, 28035, 3, 1964, 7647, 1927, 10519, 3227, 1922, 43, 3087, 1927, 5352, 10144, 1956, 28035, 18, 1920, 12446, 4727, 1927, 5481, 8740, 16, 18469, 16, 1930, 43, 4403, 3]}, "items": [{"id": "p_3389", "content": "Respiratory Sounds [SEP] Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 15779, 3, 6036, 1036, 16, 2791, 1930, 4552, 16, 22938, 1990, 18238, 18021, 19174, 1943, 2338, 2967, 3131, 1927, 1920, 5481, 6482, 18, 3]}]}
{"query": {"id": "q_3390", "content": "respiratory distress [SEP] in a case of pulmonary edema with wheezing. The sudden onset of respiratory distress, rash, and a history of a new medicine led the two paramedics o", "tokenized_content": [2, 5481, 8740, 3, 1922, 43, 3087, 1927, 5352, 10144, 1956, 28035, 18, 1920, 12446, 4727, 1927, 5481, 8740, 16, 18469, 16, 1930, 43, 4403, 1927, 43, 2814, 5380, 4866, 1920, 3]}, "items": [{"id": "p_3390", "content": "Respiratory Distress Syndrome, Adult [SEP] A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usuall", "score": 1, "type": null, "tokenized_content": [2, 5481, 8740, 4741, 16, 4160, 3, 43, 4741, 4378, 2007, 7529, 3308, 17, 13281, 5481, 14566, 1922, 1920, 3905, 1927, 3171, 3614, 3902, 16, 10616, 1024, 3]}]}
{"query": {"id": "q_3391", "content": "rash [SEP]  edema with wheezing. The sudden onset of respiratory distress, rash, and a history of a new medicine led the two paramedics on the ", "tokenized_content": [2, 18469, 3, 10144, 1956, 28035, 18, 1920, 12446, 4727, 1927, 5481, 8740, 16, 18469, 16, 1930, 43, 4403, 1927, 43, 2814, 5380, 4866, 1920, 2288, 3167, 29531, 1990, 1920, 3]}, "items": [{"id": "p_3391", "content": "Exanthema [SEP] Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with sim", "score": 1, "type": null, "tokenized_content": [2, 1975, 7744, 6666, 3, 3902, 1922, 2154, 4407, 25655, 1036, 2014, 18469, 1918, 2032, 43, 8753, 15570, 18, 24466, 16, 3798, 2427, 3902, 1985, 2910, 1956, 2328, 3]}]}
{"query": {"id": "q_3392", "content": "epinephrine [SEP]  led the two paramedics on the scene to administer subcutaneous epinephrine. Subsequently, acute cardiac arrest and fatal subarachnoid hemo", "tokenized_content": [2, 19280, 3, 4866, 1920, 2288, 3167, 29531, 1990, 1920, 17235, 1942, 15487, 8634, 19280, 18, 5326, 16, 3939, 4435, 8048, 1930, 11990, 23795, 3243, 1037, 3]}, "items": [{"id": "p_3392", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_3393", "content": "cardiac arrest [SEP] ene to administer subcutaneous epinephrine. Subsequently, acute cardiac arrest and fatal subarachnoid hemorrhage occurred. Epinephrine has a p", "tokenized_content": [2, 4435, 8048, 3, 2066, 1021, 1942, 15487, 8634, 19280, 18, 5326, 16, 3939, 4435, 8048, 1930, 11990, 23795, 10489, 4807, 18, 19280, 2258, 43, 58, 3]}, "items": [{"id": "p_3393", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_3394", "content": "subarachnoid hemorrhage [SEP] neous epinephrine. Subsequently, acute cardiac arrest and fatal subarachnoid hemorrhage occurred. Epinephrine has a proven role in cardiac arrest in pr", "tokenized_content": [2, 23795, 10489, 3, 11724, 1957, 19280, 18, 5326, 16, 3939, 4435, 8048, 1930, 11990, 23795, 10489, 4807, 18, 19280, 2258, 43, 9253, 2770, 1922, 4435, 8048, 1922, 2033, 3]}, "items": [{"id": "p_3394", "content": "Subarachnoid Hemorrhage [SEP] Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur aft", "score": 1, "type": null, "tokenized_content": [2, 23795, 10489, 3, 7633, 2460, 1920, 12179, 2014, 6071, 23795, 5230, 16, 2501, 3864, 2037, 12179, 13373, 12460, 18, 2176, 2112, 4704, 2221, 1031, 3]}]}
{"query": {"id": "q_3395", "content": "Epinephrine [SEP] cute cardiac arrest and fatal subarachnoid hemorrhage occurred. Epinephrine has a proven role in cardiac arrest in prehospital care; howeve", "tokenized_content": [2, 19280, 3, 4665, 1021, 4435, 8048, 1930, 11990, 23795, 10489, 4807, 18, 19280, 2258, 43, 9253, 2770, 1922, 4435, 8048, 1922, 21161, 21605, 2859, 31, 2307, 9488, 1021, 3]}, "items": [{"id": "p_3395", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_3396", "content": "hypertension [SEP] amedics in patients with suspected allergic reaction and severe hypertension should be viewed with caution.", "tokenized_content": [2, 5579, 3, 2150, 29531, 1922, 2132, 1956, 9407, 10519, 3227, 1930, 4010, 5579, 3066, 1998, 11103, 1956, 12838, 18, 3]}, "items": [{"id": "p_3396", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3397", "content": "rhabdomyolysis [SEP] A case of massive rhabdomyolysis following molindone administration.", "tokenized_content": [2, 25369, 6892, 3, 43, 3087, 1927, 12944, 25369, 6892, 2894, 2629, 2762, 2290, 4183, 18, 3]}, "items": [{"id": "p_3397", "content": "Rhabdomyolysis [SEP] Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25369, 6892, 3, 7476, 2014, 22398, 1943, 1927, 7345, 3760, 3868, 3489, 2007, 15924, 4365, 17428, 1022, 8754, 18, 3]}]}
{"query": {"id": "q_3398", "content": "molindone [SEP] A case of massive rhabdomyolysis following molindone administration.", "tokenized_content": [2, 2629, 2762, 2290, 3, 43, 3087, 1927, 12944, 25369, 6892, 2894, 2629, 2762, 2290, 4183, 18, 3]}, "items": [{"id": "p_3398", "content": "Molindone [SEP] An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type ", "score": 1, "type": null, "tokenized_content": [2, 2629, 2762, 2290, 3, 1925, 18050, 10533, 3655, 1922, 7899, 1930, 2303, 9855, 1918, 1930, 6553, 4707, 1922, 1920, 2311, 1927, 1920, 8704, 2601, 3]}]}
{"query": {"id": "q_3399", "content": "Rhabdomyolysis [SEP] Rhabdomyolysis is a potentially lethal syndrome that psychiatric patients seem", "tokenized_content": [2, 25369, 6892, 3, 25369, 6892, 1977, 43, 5063, 10470, 4741, 1988, 7652, 2132, 6521, 3]}, "items": [{"id": "p_3399", "content": "Rhabdomyolysis [SEP] Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25369, 6892, 3, 7476, 2014, 22398, 1943, 1927, 7345, 3760, 3868, 3489, 2007, 15924, 4365, 17428, 1022, 8754, 18, 3]}]}
{"query": {"id": "q_3400", "content": "psychiatric [SEP] Rhabdomyolysis is a potentially lethal syndrome that psychiatric patients seem predisposed to develop. The clinical signs and sy", "tokenized_content": [2, 7652, 3, 25369, 6892, 1977, 43, 5063, 10470, 4741, 1988, 7652, 2132, 6521, 23002, 1007, 1942, 2392, 18, 1920, 2535, 6879, 1930, 7930, 3]}, "items": [{"id": "p_3400", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_3401", "content": "rhabdomyolysis [SEP] and symptoms, typical laboratory features, and complications of rhabdomyolysis are presented. The case of a schizophrenic patient is reported ", "tokenized_content": [2, 25369, 6892, 3, 1930, 3601, 16, 5939, 4542, 4075, 16, 1930, 5021, 1927, 25369, 6892, 2032, 3549, 18, 1920, 3087, 1927, 43, 28247, 2774, 1977, 2568, 3]}, "items": [{"id": "p_3401", "content": "Rhabdomyolysis [SEP] Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25369, 6892, 3, 7476, 2014, 22398, 1943, 1927, 7345, 3760, 3868, 3489, 2007, 15924, 4365, 17428, 1022, 8754, 18, 3]}]}
{"query": {"id": "q_3402", "content": "schizophrenic [SEP] nd complications of rhabdomyolysis are presented. The case of a schizophrenic patient is reported to illustrate massive rhabdomyolysis and su", "tokenized_content": [2, 28247, 3, 8026, 5021, 1927, 25369, 6892, 2032, 3549, 18, 1920, 3087, 1927, 43, 28247, 2774, 1977, 2568, 1942, 11197, 12944, 25369, 6892, 1930, 2020, 3]}, "items": [{"id": "p_3402", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_3403", "content": "acute renal failure [SEP] is reported to illustrate massive rhabdomyolysis and subsequent acute renal failure following molindone administration. Physicians who prescribe mo", "tokenized_content": [2, 3939, 4604, 4574, 3, 1977, 2568, 1942, 11197, 12944, 25369, 6892, 1930, 4521, 3939, 4604, 4574, 2894, 2629, 2762, 2290, 4183, 18, 6967, 2746, 30333, 2661, 3]}, "items": [{"id": "p_3403", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_3404", "content": "molindone [SEP] ive rhabdomyolysis and subsequent acute renal failure following molindone administration. Physicians who prescribe molindone should be aw", "tokenized_content": [2, 2629, 2762, 2290, 3, 4370, 1021, 25369, 6892, 1930, 4521, 3939, 4604, 4574, 2894, 2629, 2762, 2290, 4183, 18, 6967, 2746, 30333, 2629, 2762, 2290, 3066, 1998, 6727, 3]}, "items": [{"id": "p_3404", "content": "Molindone [SEP] An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type ", "score": 1, "type": null, "tokenized_content": [2, 2629, 2762, 2290, 3, 1925, 18050, 10533, 3655, 1922, 7899, 1930, 2303, 9855, 1918, 1930, 6553, 4707, 1922, 1920, 2311, 1927, 1920, 8704, 2601, 3]}]}
{"query": {"id": "q_3405", "content": "Cardiovascular alterations [SEP] Cardiovascular alterations in rat fetuses exposed to calcium channel blockers.", "tokenized_content": [2, 5321, 5996, 3, 5321, 5996, 1922, 3067, 16110, 4616, 1942, 5016, 4999, 13628, 18, 3]}, "items": [{"id": "p_3405", "content": "Cardiovascular Abnormalities [SEP] Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 6754, 3, 9901, 16, 12911, 16, 2014, 5815, 13621, 1927, 1920, 5321, 2433, 16, 2710, 1920, 4003, 1930, 2877, 7208, 18, 3]}]}
{"query": {"id": "q_3406", "content": "calcium [SEP] Cardiovascular alterations in rat fetuses exposed to calcium channel blockers.", "tokenized_content": [2, 5016, 3, 5321, 5996, 1922, 3067, 16110, 4616, 1942, 5016, 4999, 13628, 18, 3]}, "items": [{"id": "p_3406", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_3407", "content": "calcium [SEP] Preclinical toxicologic investigation suggested that a new calcium channel blocker, Ro 40-5967, induced cardiovascular alterations", "tokenized_content": [2, 5016, 3, 10311, 6161, 4467, 5630, 3978, 1988, 43, 2814, 5016, 4999, 14580, 16, 3039, 3040, 17, 4777, 6038, 16, 2719, 5321, 5996, 3]}, "items": [{"id": "p_3407", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_3408", "content": "Ro 40-5967 [SEP] gic investigation suggested that a new calcium channel blocker, Ro 40-5967, induced cardiovascular alterations in rat fetuses exposed to t", "tokenized_content": [2, 3039, 3040, 17, 4777, 6038, 3, 7217, 1030, 5630, 3978, 1988, 43, 2814, 5016, 4999, 14580, 16, 3039, 3040, 17, 4777, 6038, 16, 2719, 5321, 5996, 1922, 3067, 16110, 4616, 3]}, "items": [{"id": "p_3408", "content": "Mibefradil [SEP] A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19410, 7726, 26208, 1970, 3, 43, 7334, 26060, 19370, 2199, 17, 11798, 12470, 3701, 1988, 9331, 6876, 1930, 7042, 5016, 5628, 16, 62, 17, 2601, 18, 3]}]}
{"query": {"id": "q_3409", "content": "cardiovascular alterations [SEP] ggested that a new calcium channel blocker, Ro 40-5967, induced cardiovascular alterations in rat fetuses exposed to this agent during organogenesis. The ", "tokenized_content": [2, 5321, 5996, 3, 12358, 8198, 1988, 43, 2814, 5016, 4999, 14580, 16, 3039, 3040, 17, 4777, 6038, 16, 2719, 5321, 5996, 1922, 3067, 16110, 4616, 1942, 2052, 5899, 2409, 3090, 3]}, "items": [{"id": "p_3409", "content": "Cardiovascular Abnormalities [SEP] Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 6754, 3, 9901, 16, 12911, 16, 2014, 5815, 13621, 1927, 1920, 5321, 2433, 16, 2710, 1920, 4003, 1930, 2877, 7208, 18, 3]}]}
{"query": {"id": "q_3410", "content": "cardiovascular malformations [SEP]  the hypothesis that calcium channel blockers in general induce cardiovascular malformations indicating a pharmacologic class effect. We studied three calci", "tokenized_content": [2, 5321, 17360, 3, 1920, 4676, 1988, 5016, 4999, 13628, 1922, 3335, 4769, 5321, 17360, 4168, 43, 17225, 2921, 2495, 18, 2038, 3942, 2559, 2799, 1033, 3]}, "items": [{"id": "p_3410", "content": "Cardiovascular Abnormalities [SEP] Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 6754, 3, 9901, 16, 12911, 16, 2014, 5815, 13621, 1927, 1920, 5321, 2433, 16, 2710, 1920, 4003, 1930, 2877, 7208, 18, 3]}]}
{"query": {"id": "q_3411", "content": "nifedipine [SEP]  studied three calcium channel blockers of different structure, nifedipine, diltiazem, and verapamil, along with the new agent. Pregnant r", "tokenized_content": [2, 25968, 3, 3942, 2559, 5016, 4999, 13628, 1927, 2413, 3170, 16, 25968, 16, 4333, 11574, 6931, 1035, 16, 1930, 23300, 16, 4231, 1956, 1920, 2814, 5899, 18, 7808, 60, 3]}, "items": [{"id": "p_3411", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_3412", "content": "diltiazem [SEP] ee calcium channel blockers of different structure, nifedipine, diltiazem, and verapamil, along with the new agent. Pregnant rats were ad", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 11150, 5016, 4999, 13628, 1927, 2413, 3170, 16, 25968, 16, 4333, 11574, 6931, 1035, 16, 1930, 23300, 16, 4231, 1956, 1920, 2814, 5899, 18, 7808, 3]}, "items": [{"id": "p_3412", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_3413", "content": "verapamil [SEP] nel blockers of different structure, nifedipine, diltiazem, and verapamil, along with the new agent. Pregnant rats were administered one ", "tokenized_content": [2, 23300, 3, 2069, 1024, 13628, 1927, 2413, 3170, 16, 25968, 16, 4333, 11574, 6931, 1035, 16, 1930, 23300, 16, 4231, 1956, 1920, 2814, 5899, 18, 7808, 3615, 1985, 5254, 2340, 3]}, "items": [{"id": "p_3413", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_3414", "content": "lamivudine [SEP] f immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative st", "tokenized_content": [2, 30208, 3, 48, 3743, 11781, 3527, 8533, 6803, 1005, 1930, 29736, 1031, 1990, 1920, 5158, 1927, 30208, 17, 4910, 7977, 44, 3413, 47, 4730, 17, 2843, 1930, 17, 3136, 1955, 3]}, "items": [{"id": "p_3414", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_3415", "content": "hepatitis B virus e antigen [SEP] ions G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains.", "tokenized_content": [2, 7977, 44, 3413, 47, 4730, 3, 6982, 8533, 6803, 1005, 1930, 29736, 1031, 1990, 1920, 5158, 1927, 30208, 17, 4910, 7977, 44, 3413, 47, 4730, 17, 2843, 1930, 17, 3136, 3]}, "items": [{"id": "p_3415", "content": "Hepatitis B e Antigens [SEP] A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic he", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 47, 7769, 3, 43, 6538, 2712, 2210, 1927, 7769, 2435, 1922, 1920, 3582, 2444, 2409, 1920, 20905, 3193, 1927, 7977, 44, 2014, 1922, 18354, 3724, 2234, 3]}]}
{"query": {"id": "q_3416", "content": "hepatitis B [SEP] Immune escape variants of the hepatitis B virus (HBV) represent an emerging clinical challenge, because t", "tokenized_content": [2, 7977, 44, 3, 3743, 11781, 4936, 1927, 1920, 7977, 44, 3413, 12, 8738, 13, 3015, 1925, 8484, 2535, 6013, 16, 2882, 62, 3]}, "items": [{"id": "p_3416", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_3417", "content": "lamivudine [SEP] ility of common treatment-associated mutants with resistance to lamivudine (LAM) and/or HBeAg negativity. Replication-competent HBV strain", "tokenized_content": [2, 30208, 3, 14872, 3145, 1927, 3059, 2311, 17, 2458, 4674, 1956, 3554, 1942, 30208, 12, 8282, 13, 1930, 19, 2014, 25162, 24367, 18, 5158, 17, 13527, 8738, 3943, 3]}, "items": [{"id": "p_3417", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_3418", "content": "LAM [SEP] mon treatment-associated mutants with resistance to lamivudine (LAM) and/or HBeAg negativity. Replication-competent HBV strains wit", "tokenized_content": [2, 8282, 3, 2399, 2311, 17, 2458, 4674, 1956, 3554, 1942, 30208, 12, 8282, 13, 1930, 19, 2014, 25162, 24367, 18, 5158, 17, 13527, 8738, 4046, 16086, 3]}, "items": [{"id": "p_3418", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_3419", "content": "HBeAg [SEP] t-associated mutants with resistance to lamivudine (LAM) and/or HBeAg negativity. Replication-competent HBV strains with sG145R or sP", "tokenized_content": [2, 25162, 3, 62, 17, 2458, 4674, 1956, 3554, 1942, 30208, 12, 8282, 13, 1930, 19, 2014, 25162, 24367, 18, 5158, 17, 13527, 8738, 4046, 1956, 10075, 16416, 1005, 2014, 2056, 3]}, "items": [{"id": "p_3419", "content": "Hepatitis B e Antigens [SEP] A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic he", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 47, 7769, 3, 43, 6538, 2712, 2210, 1927, 7769, 2435, 1922, 1920, 3582, 2444, 2409, 1920, 20905, 3193, 1927, 7977, 44, 2014, 1922, 18354, 3724, 2234, 3]}]}
{"query": {"id": "q_3420", "content": "HBsAg [SEP] re promoter (BCP) mutants. The sG145R mutation strongly reduced HBsAg levels and was able to fully restore the impaired replication o", "tokenized_content": [2, 17596, 3, 1964, 4465, 12, 29400, 13, 4674, 18, 1920, 10075, 16416, 1005, 3979, 4937, 3028, 17596, 2428, 1930, 1982, 4236, 1942, 5437, 12900, 1920, 5761, 5158, 57, 3]}, "items": [{"id": "p_3420", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_3421", "content": "nucleotide [SEP] s with combined immune escape and LAM resistance mutations, the nucleotide analogues adefovir and tenofovir remained effective in suppress", "tokenized_content": [2, 5489, 3, 61, 1956, 4252, 3743, 11781, 1930, 8282, 3554, 3527, 16, 1920, 5489, 13645, 23846, 15282, 3026, 1930, 29122, 5410, 3655, 1922, 4400, 3]}, "items": [{"id": "p_3421", "content": "Nucleotides [SEP] The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar", "score": 1, "type": null, "tokenized_content": [2, 9519, 3, 1920, 14457, 5701, 2037, 2154, 2678, 2014, 3146, 11039, 2032, 6857, 18, 2611, 3149, 1927, 43, 19700, 2014, 21611, 5170, 16, 43, 9412, 2217, 9523, 3]}]}
{"query": {"id": "q_3422", "content": "adefovir [SEP] e escape and LAM resistance mutations, the nucleotide analogues adefovir and tenofovir remained effective in suppressing viral replicati", "tokenized_content": [2, 23846, 15282, 3026, 3, 47, 11781, 1930, 8282, 3554, 3527, 16, 1920, 5489, 13645, 23846, 15282, 3026, 1930, 29122, 5410, 3655, 1922, 13556, 4324, 5825, 1968, 3]}, "items": [{"id": "p_3422", "content": "adefovir [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23846, 15282, 3026, 3, 3]}]}
{"query": {"id": "q_3423", "content": "tenofovir [SEP] LAM resistance mutations, the nucleotide analogues adefovir and tenofovir remained effective in suppressing viral replication in vitro. T", "tokenized_content": [2, 29122, 3, 8282, 3554, 3527, 16, 1920, 5489, 13645, 23846, 15282, 3026, 1930, 29122, 5410, 3655, 1922, 13556, 4324, 5158, 1922, 3596, 18, 62, 3]}, "items": [{"id": "p_3423", "content": "tenofovir [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 29122, 3, 3]}]}
{"query": {"id": "q_3424", "content": "sevoflurane [SEP] The effects of sevoflurane on lidocaine-induced convulsions.", "tokenized_content": [2, 25564, 3, 1920, 2564, 1927, 25564, 1990, 19567, 17, 2719, 4772, 19389, 18, 3]}, "items": [{"id": "p_3424", "content": "sevoflurane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25564, 3, 3]}]}
{"query": {"id": "q_3425", "content": "lidocaine [SEP] The effects of sevoflurane on lidocaine-induced convulsions.", "tokenized_content": [2, 19567, 3, 1920, 2564, 1927, 25564, 1990, 19567, 17, 2719, 4772, 19389, 18, 3]}, "items": [{"id": "p_3425", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_3426", "content": "convulsions [SEP] The effects of sevoflurane on lidocaine-induced convulsions.", "tokenized_content": [2, 4772, 19389, 3, 1920, 2564, 1927, 25564, 1990, 19567, 17, 2719, 4772, 19389, 18, 3]}, "items": [{"id": "p_3426", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3427", "content": "sevoflurane [SEP] The influence of sevoflurane on lidocaine-induced convulsions was studied in cats. The convu", "tokenized_content": [2, 25564, 3, 1920, 4039, 1927, 25564, 1990, 19567, 17, 2719, 4772, 19389, 1982, 3942, 1922, 12408, 18, 1920, 4772, 1032, 3]}, "items": [{"id": "p_3427", "content": "sevoflurane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25564, 3, 3]}]}
{"query": {"id": "q_3428", "content": "lidocaine [SEP] The influence of sevoflurane on lidocaine-induced convulsions was studied in cats. The convulsive thresho", "tokenized_content": [2, 19567, 3, 1920, 4039, 1927, 25564, 1990, 19567, 17, 2719, 4772, 19389, 1982, 3942, 1922, 12408, 18, 1920, 4772, 13042, 26642, 1037, 3]}, "items": [{"id": "p_3428", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_3429", "content": "convulsions [SEP] The influence of sevoflurane on lidocaine-induced convulsions was studied in cats. The convulsive threshold (mean +/- SD) was", "tokenized_content": [2, 4772, 19389, 3, 1920, 4039, 1927, 25564, 1990, 19567, 17, 2719, 4772, 19389, 1982, 3942, 1922, 12408, 18, 1920, 4772, 13042, 4683, 12, 2667, 15, 19, 17, 4035, 13, 1982, 3]}, "items": [{"id": "p_3429", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3430", "content": "convulsive [SEP] urane on lidocaine-induced convulsions was studied in cats. The convulsive threshold (mean +/- SD) was 41.4 +/- 6.5 mg. l(-1) with lidocai", "tokenized_content": [2, 4772, 13042, 3, 3674, 2516, 1990, 19567, 17, 2719, 4772, 19389, 1982, 3942, 1922, 12408, 18, 1920, 4772, 13042, 4683, 12, 2667, 15, 19, 17, 4035, 13, 1982, 4353, 18, 3]}, "items": [{"id": "p_3430", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3431", "content": "enflurane [SEP]  difference in the convulsive threshold between sevoflurane and enflurane. The rise in blood pressure became less marked when higher conc", "tokenized_content": [2, 2066, 12676, 3, 3175, 1922, 1920, 4772, 13042, 4683, 2192, 25564, 1930, 2066, 12676, 18, 1920, 7164, 1922, 2877, 3772, 7935, 2941, 4961, 2469, 2580, 2499, 3]}, "items": [{"id": "p_3431", "content": "Enflurane [SEP] An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respi", "score": 1, "type": null, "tokenized_content": [2, 2066, 12676, 3, 1925, 8113, 4700, 14728, 16111, 1988, 5731, 4052, 15852, 1927, 8871, 6070, 1956, 5082, 3185, 1922, 7110, 2014, 2163, 1033, 3]}]}
{"query": {"id": "q_3432", "content": "Apamin [SEP] tions measured when the systolic blood pressure became 70 mmHg. Apamin, a selective blocker of calcium-dependent potassium channels, w", "tokenized_content": [2, 24162, 8547, 3, 8685, 2101, 3045, 2469, 1920, 8541, 2877, 3772, 7935, 3895, 9348, 18, 24162, 8547, 16, 43, 5328, 14580, 1927, 5016, 17, 3100, 9057, 5628, 16, 65, 3]}, "items": [{"id": "p_3432", "content": "Apamin [SEP] A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfi", "score": 1, "type": null, "tokenized_content": [2, 24162, 8547, 3, 43, 3626, 20919, 13022, 2037, 1920, 15540, 1927, 1920, 16400, 20006, 12, 20655, 1036, 9072, 19582, 13, 18, 2176, 7543, 1927, 2654, 3835, 4576, 1956, 2288, 10993, 1033, 3]}]}
{"query": {"id": "q_3433", "content": "calcium [SEP] c blood pressure became 70 mmHg. Apamin, a selective blocker of calcium-dependent potassium channels, was administered intracerebrovent", "tokenized_content": [2, 5016, 3, 45, 2877, 3772, 7935, 3895, 9348, 18, 24162, 8547, 16, 43, 5328, 14580, 1927, 5016, 17, 3100, 9057, 5628, 16, 1982, 5254, 19343, 18474, 5954, 3]}, "items": [{"id": "p_3433", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_3434", "content": "potassium [SEP] ecame 70 mmHg. Apamin, a selective blocker of calcium-dependent potassium channels, was administered intracerebroventricularly in rats an", "tokenized_content": [2, 9057, 3, 3270, 4171, 3895, 9348, 18, 24162, 8547, 16, 43, 5328, 14580, 1927, 5016, 17, 3100, 9057, 5628, 16, 1982, 5254, 19343, 18474, 24722, 1954, 1922, 3615, 1925, 3]}, "items": [{"id": "p_3434", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_3435", "content": "toxicity [SEP] ted that sevoflurane reduces the convulsive effect of lidocaine toxicity but carries some risk due to circulatory depression.", "tokenized_content": [2, 5532, 3, 26080, 1988, 25564, 7268, 1920, 4772, 13042, 2495, 1927, 19567, 5532, 2308, 16252, 2673, 2565, 2810, 1942, 19844, 4621, 18, 3]}, "items": [{"id": "p_3435", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3436", "content": "depression [SEP]  of lidocaine toxicity but carries some risk due to circulatory depression.", "tokenized_content": [2, 4621, 3, 1927, 19567, 5532, 2308, 16252, 2673, 2565, 2810, 1942, 19844, 4621, 18, 3]}, "items": [{"id": "p_3436", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_3437", "content": "atorvastatin [SEP] Anti-oxidant effects of atorvastatin in dexamethasone-induced hypertension in the rat.", "tokenized_content": [2, 23489, 3, 2246, 17, 16138, 2564, 1927, 23489, 1922, 12681, 17, 2719, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_3437", "content": "atorvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23489, 3, 3]}]}
{"query": {"id": "q_3438", "content": "dexamethasone [SEP] Anti-oxidant effects of atorvastatin in dexamethasone-induced hypertension in the rat.", "tokenized_content": [2, 12681, 3, 2246, 17, 16138, 2564, 1927, 23489, 1922, 12681, 17, 2719, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_3438", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_3439", "content": "hypertension [SEP] Anti-oxidant effects of atorvastatin in dexamethasone-induced hypertension in the rat.", "tokenized_content": [2, 5579, 3, 2246, 17, 16138, 2564, 1927, 23489, 1922, 12681, 17, 2719, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_3439", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3440", "content": "Dexamethasone [SEP] 1. Dexamethasone (Dex)-induced hypertension is characterized by endothelial dysf", "tokenized_content": [2, 12681, 3, 21, 18, 12681, 12, 7473, 13, 17, 2719, 5579, 1977, 4378, 2007, 5003, 3890, 1038, 3]}, "items": [{"id": "p_3440", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_3441", "content": "Dex [SEP] 1. Dexamethasone (Dex)-induced hypertension is characterized by endoth", "tokenized_content": [2, 7473, 3, 21, 18, 12681, 12, 7473, 13, 17, 2719, 5579, 1977, 4378, 2007, 4579, 3]}, "items": [{"id": "p_3441", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_3442", "content": "hypertension [SEP] 1. Dexamethasone (Dex)-induced hypertension is characterized by endothelial dysfunction associated with nit", "tokenized_content": [2, 5579, 3, 21, 18, 12681, 12, 7473, 13, 17, 2719, 5579, 1977, 4378, 2007, 5003, 5273, 2458, 1956, 7904, 3]}, "items": [{"id": "p_3442", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_3443", "content": "nitric oxide [SEP] ion is characterized by endothelial dysfunction associated with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Ator", "tokenized_content": [2, 10233, 7491, 3, 4755, 1977, 4378, 2007, 5003, 5273, 2458, 1956, 10233, 7491, 12, 2239, 13, 6179, 1930, 2502, 10738, 12, 8259, 17, 13, 3372, 18, 22973, 3]}, "items": [{"id": "p_3443", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_3444", "content": "NO [SEP] erized by endothelial dysfunction associated with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Atorvast", "tokenized_content": [2, 2239, 3, 2668, 2301, 2007, 5003, 5273, 2458, 1956, 10233, 7491, 12, 2239, 13, 6179, 1930, 2502, 10738, 12, 8259, 17, 13, 3372, 18, 22973, 10916, 1031, 3]}, "items": [{"id": "p_3444", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_3445", "content": "superoxide [SEP] tion associated with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic prop", "tokenized_content": [2, 10738, 3, 8685, 1916, 2458, 1956, 10233, 7491, 12, 2239, 13, 6179, 1930, 2502, 10738, 12, 8259, 17, 13, 3372, 18, 23489, 12, 2019, 1037, 13, 14465, 20233, 5062, 3]}, "items": [{"id": "p_3445", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_3446", "content": "O2- [SEP] ted with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic propertie", "tokenized_content": [2, 8259, 17, 3, 26080, 1956, 10233, 7491, 12, 2239, 13, 6179, 1930, 2502, 10738, 12, 8259, 17, 13, 3372, 18, 23489, 12, 2019, 1037, 13, 14465, 20233, 3405, 24866, 3]}, "items": [{"id": "p_3446", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_3447", "content": "Atorvastatin [SEP] xide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic properties that have been reported ", "tokenized_content": [2, 23489, 3, 11551, 3695, 12, 2239, 13, 6179, 1930, 2502, 10738, 12, 8259, 17, 13, 3372, 18, 23489, 12, 2019, 1037, 13, 14465, 20233, 3879, 1988, 2162, 2252, 2568, 3]}, "items": [{"id": "p_3447", "content": "atorvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23489, 3, 3]}]}
{"query": {"id": "q_3448", "content": "Ato [SEP] xide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic properties that have been ", "tokenized_content": [2, 2019, 1037, 3, 11551, 3695, 12, 2239, 13, 6179, 1930, 2502, 10738, 12, 8259, 17, 13, 3372, 18, 23489, 12, 2019, 1037, 13, 14465, 20233, 3879, 1988, 2162, 2252, 3]}, "items": [{"id": "p_3448", "content": "atorvastatin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23489, 3, 3]}]}
{"query": {"id": "q_3449", "content": "acetylcholine [SEP] sing the tail-cuff method. Endothelial function was assessed by acetylcholine-induced vasorelaxation and phenylephrine-induced vasoconstricti", "tokenized_content": [2, 14561, 3, 2896, 1920, 5281, 17, 14987, 2417, 18, 5003, 2347, 1982, 3683, 2007, 14561, 17, 2719, 22866, 5703, 3013, 1943, 1930, 27053, 17, 2719, 28404, 1914, 3]}, "items": [{"id": "p_3449", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_3450", "content": "phenylephrine [SEP] nction was assessed by acetylcholine-induced vasorelaxation and phenylephrine-induced vasoconstriction in aortic segments. Vascular eNOS mRNA", "tokenized_content": [2, 27053, 3, 10409, 2001, 1982, 3683, 2007, 14561, 17, 2719, 22866, 5703, 3013, 1943, 1930, 27053, 17, 2719, 21843, 1922, 7677, 7492, 18, 4541, 14298, 3616, 3]}, "items": [{"id": "p_3450", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_3451", "content": "99mTc-glucarate [SEP] 99mTc-glucarate for detection of isoproterenol-induced myocardial infarction in", "tokenized_content": [2, 22091, 17, 3351, 17488, 3, 22091, 17, 3351, 17488, 1958, 3805, 1927, 23743, 17, 2719, 6497, 8358, 1922, 3]}, "items": [{"id": "p_3451", "content": "technetium Tc 99m glucarate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2913, 4988, 1989, 5283, 17660, 3351, 17488, 3, 3]}]}
{"query": {"id": "q_3452", "content": "isoproterenol [SEP] 99mTc-glucarate for detection of isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 23743, 3, 22091, 17, 3351, 17488, 1958, 3805, 1927, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_3452", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_3453", "content": "myocardial infarction [SEP] 99mTc-glucarate for detection of isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 6497, 8358, 3, 22091, 17, 3351, 17488, 1958, 3805, 1927, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_3453", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_3454", "content": "Infarct [SEP] Infarct-avid radiopharmaceuticals are necessary for rapid and timely di", "tokenized_content": [2, 13389, 3, 13389, 17, 22731, 1007, 8466, 4151, 23745, 8565, 14511, 2032, 4680, 1958, 4052, 1930, 14918, 2137, 3]}, "items": [{"id": "p_3454", "content": "Infarction [SEP] Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most", "score": 1, "type": null, "tokenized_content": [2, 8358, 3, 3337, 1927, 1925, 13389, 16, 2154, 1977, 7476, 1922, 2960, 2810, 1942, 3076, 7716, 3864, 2037, 10849, 1927, 2877, 9255, 16, 2501, 3]}]}
{"query": {"id": "q_3455", "content": "myocardial infarction [SEP] ceuticals are necessary for rapid and timely diagnosis of acute myocardial infarction. The animal model used to produce infarction implies artery lig", "tokenized_content": [2, 6497, 8358, 3, 5827, 1984, 2046, 1036, 2032, 4680, 1958, 4052, 1930, 14918, 3574, 1927, 3939, 6497, 8358, 18, 1920, 4027, 2322, 2251, 1942, 5074, 8358, 10715, 5511, 3650, 3]}, "items": [{"id": "p_3455", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_3456", "content": "infarction [SEP] re necessary for rapid and timely diagnosis of acute myocardial infarction. The animal model used to produce infarction implies artery lig", "tokenized_content": [2, 8358, 3, 1964, 4680, 1958, 4052, 1930, 14918, 3574, 1927, 3939, 6497, 8358, 18, 1920, 4027, 2322, 2251, 1942, 5074, 8358, 10715, 5511, 3650, 3]}, "items": [{"id": "p_3456", "content": "Infarction [SEP] Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most", "score": 1, "type": null, "tokenized_content": [2, 8358, 3, 3337, 1927, 1925, 13389, 16, 2154, 1977, 7476, 1922, 2960, 2810, 1942, 3076, 7716, 3864, 2037, 10849, 1927, 2877, 9255, 16, 2501, 3]}]}
{"query": {"id": "q_3457", "content": "isoproterenol [SEP] ery ligation but chemical induction can be easily obtained with isoproterenol. A new infarct-avid radiopharmaceutical based on glucaric acid ", "tokenized_content": [2, 23743, 3, 2668, 1012, 11102, 2308, 4399, 4408, 2112, 1998, 7278, 2926, 1956, 23743, 18, 43, 2814, 13389, 17, 22731, 1007, 8466, 4151, 23745, 8565, 2506, 2454, 1990, 3351, 28867, 3]}, "items": [{"id": "p_3457", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_3458", "content": "infarct [SEP] re necessary for rapid and timely diagnosis of acute myocardial infarction. The animal model used to produce infarction implies artery ", "tokenized_content": [2, 13389, 3, 1964, 4680, 1958, 4052, 1930, 14918, 3574, 1927, 3939, 6497, 8358, 18, 1920, 4027, 2322, 2251, 1942, 5074, 8358, 10715, 5511, 3]}, "items": [{"id": "p_3458", "content": "Infarction [SEP] Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most", "score": 1, "type": null, "tokenized_content": [2, 8358, 3, 3337, 1927, 1925, 13389, 16, 2154, 1977, 7476, 1922, 2960, 2810, 1942, 3076, 7716, 3864, 2037, 10849, 1927, 2877, 9255, 16, 2501, 3]}]}
{"query": {"id": "q_3459", "content": "glucaric acid [SEP]  isoproterenol. A new infarct-avid radiopharmaceutical based on glucaric acid was prepared in the hospital radiopharmacy of the INCMNSZ. 99mT", "tokenized_content": [2, 3351, 28867, 2687, 3, 23743, 18, 43, 2814, 13389, 17, 22731, 1007, 8466, 4151, 23745, 8565, 2506, 2454, 1990, 3351, 28867, 2687, 1982, 4649, 1922, 1920, 3461, 8466, 4151, 23745, 3]}, "items": [{"id": "p_3459", "content": "Glucaric Acid [SEP] A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl gro", "score": 1, "type": null, "tokenized_content": [2, 3351, 28867, 2687, 3, 43, 9523, 2687, 3595, 2037, 46, 17, 3817, 1922, 2154, 2321, 1920, 11174, 29586, 2584, 1935, 5056, 6761, 1930, 1920, 5056, 6761, 8188, 1920, 3065, 9420, 8947, 3]}]}
{"query": {"id": "q_3460", "content": "99mTc-glucarate [SEP] acid was prepared in the hospital radiopharmacy of the INCMNSZ. 99mTc-glucarate was easy to prepare, stable for 96 h and was used to study its ", "tokenized_content": [2, 22091, 17, 3351, 17488, 3, 2687, 1982, 4649, 1922, 1920, 3461, 8466, 4151, 23745, 3217, 1927, 1920, 2043, 18044, 1036, 1011, 18, 22091, 17, 3351, 17488, 1982, 9040, 1942, 12674, 3]}, "items": [{"id": "p_3460", "content": "technetium Tc 99m glucarate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2913, 4988, 1989, 5283, 17660, 3351, 17488, 3, 3]}]}
{"query": {"id": "q_3461", "content": "cardiac infarction [SEP] stability makes it an ideal agent to detect, in patients, early cardiac infarction.", "tokenized_content": [2, 4435, 8358, 3, 5057, 7645, 2176, 1925, 8950, 5899, 1942, 4277, 16, 1922, 2132, 16, 3120, 4435, 8358, 18, 3]}, "items": [{"id": "p_3461", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_3462", "content": "haloperidol [SEP] A randomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease.", "tokenized_content": [2, 25107, 3, 43, 5542, 16, 5936, 17, 4642, 3253, 17, 3723, 3046, 1927, 25107, 1958, 15489, 1930, 24026, 5888, 1922, 9116, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_3462", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_3463", "content": "psychosis [SEP] ed, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease.", "tokenized_content": [2, 15489, 3, 3347, 16, 5936, 17, 4642, 3253, 17, 3723, 3046, 1927, 25107, 1958, 15489, 1930, 24026, 5888, 1922, 9116, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_3463", "content": "Psychotic Disorders [SEP] Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent halluc", "score": 1, "type": null, "tokenized_content": [2, 16651, 4414, 3, 4414, 1922, 2154, 2276, 1977, 43, 3257, 1927, 7282, 1037, 11471, 2014, 43, 10461, 6159, 1922, 15928, 4213, 1956, 2723, 3910, 2014, 8753, 20958, 3]}]}
{"query": {"id": "q_3464", "content": "disruptive behaviors [SEP] ntrolled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease.", "tokenized_content": [2, 24026, 5888, 3, 20517, 2201, 1919, 3253, 17, 3723, 3046, 1927, 25107, 1958, 15489, 1930, 24026, 5888, 1922, 9116, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_3464", "content": "Attention Deficit and Disruptive Behavior Disorders [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4976, 10506, 1930, 24026, 3379, 4414, 3, 3]}]}
{"query": {"id": "q_3465", "content": "Alzheimer's disease [SEP]  trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease.", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 3046, 1927, 25107, 1958, 15489, 1930, 24026, 5888, 1922, 9116, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_3465", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_3466", "content": "haloperidol [SEP] dy was to compare the efficacy and side effects of two doses of haloperidol and placebo in the treatment of psychosis and disruptive behavi", "tokenized_content": [2, 25107, 3, 6433, 1982, 1942, 5175, 1920, 4348, 1930, 4159, 2564, 1927, 2288, 5312, 1927, 25107, 1930, 5936, 1922, 1920, 2311, 1927, 15489, 1930, 24026, 2944, 3]}, "items": [{"id": "p_3466", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_3467", "content": "psychosis [SEP] cts of two doses of haloperidol and placebo in the treatment of psychosis and disruptive behaviors in patients with Alzheimer's disease. ", "tokenized_content": [2, 15489, 3, 15359, 1927, 2288, 5312, 1927, 25107, 1930, 5936, 1922, 1920, 2311, 1927, 15489, 1930, 24026, 5888, 1922, 2132, 1956, 9116, 11, 61, 2573, 18, 3]}, "items": [{"id": "p_3467", "content": "Psychotic Disorders [SEP] Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent halluc", "score": 1, "type": null, "tokenized_content": [2, 16651, 4414, 3, 4414, 1922, 2154, 2276, 1977, 43, 3257, 1927, 7282, 1037, 11471, 2014, 43, 10461, 6159, 1922, 15928, 4213, 1956, 2723, 3910, 2014, 8753, 20958, 3]}]}
{"query": {"id": "q_3468", "content": "disruptive behaviors [SEP] es of haloperidol and placebo in the treatment of psychosis and disruptive behaviors in patients with Alzheimer's disease. METHOD: In a 6-week rando", "tokenized_content": [2, 24026, 5888, 3, 2376, 1927, 25107, 1930, 5936, 1922, 1920, 2311, 1927, 15489, 1930, 24026, 5888, 1922, 2132, 1956, 9116, 11, 61, 2573, 18, 2417, 30, 1922, 43, 26, 17, 3]}, "items": [{"id": "p_3468", "content": "Attention Deficit and Disruptive Behavior Disorders [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4976, 10506, 1930, 24026, 3379, 4414, 3, 3]}]}
{"query": {"id": "q_3469", "content": "Alzheimer's disease [SEP] reatment of psychosis and disruptive behaviors in patients with Alzheimer's disease. METHOD: In a 6-week random-assignment, double-blind, placebo-c", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 1964, 7647, 1927, 15489, 1930, 24026, 5888, 1922, 2132, 1956, 9116, 11, 61, 2573, 18, 2417, 30, 1922, 43, 26, 17, 2982, 3332, 17, 12252, 3]}, "items": [{"id": "p_3469", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_3470", "content": "psychomotor agitation [SEP] s on the Brief Psychiatric Rating Scale psychosis factor and on psychomotor agitation. Response rates according to three sets of criteria were greate", "tokenized_content": [2, 26261, 18389, 3, 61, 1990, 1920, 5310, 7652, 7276, 3536, 15489, 2991, 1930, 1990, 26261, 18389, 18, 2644, 3389, 3147, 1942, 2559, 5704, 1927, 4164, 1985, 4733, 1021, 3]}, "items": [{"id": "p_3470", "content": "Psychomotor Agitation [SEP] A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug tox", "score": 1, "type": null, "tokenized_content": [2, 26261, 18389, 3, 43, 14452, 1927, 6172, 26481, 2458, 1956, 2502, 4842, 2455, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 7580, 2433, 2838, 3780, 3]}]}
{"query": {"id": "q_3471", "content": "extrapyramidal signs [SEP] ndard dose over low dose was replicated in phase B. In phase A, extrapyramidal signs tended to be greater with the standard dose than in the other t", "tokenized_content": [2, 21346, 3553, 25238, 1923, 6879, 3, 8026, 2211, 3253, 2338, 2330, 3253, 1982, 13169, 1922, 3193, 44, 18, 1922, 3193, 43, 16, 21346, 3553, 25238, 1923, 6879, 10587, 1942, 1998, 3]}, "items": [{"id": "p_3471", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_3472", "content": "adriamycin [SEP] in renal ACE activity in healthy rats predict susceptibility to adriamycin-induced renal damage.", "tokenized_content": [2, 25622, 7898, 3, 1922, 4604, 8298, 2455, 1922, 4097, 3615, 5660, 6461, 1942, 25622, 7898, 17, 2719, 4604, 4293, 18, 3]}, "items": [{"id": "p_3472", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3473", "content": "renal damage [SEP] ty in healthy rats predict susceptibility to adriamycin-induced renal damage.", "tokenized_content": [2, 4604, 4293, 3, 6227, 1922, 4097, 3615, 5660, 6461, 1942, 25622, 7898, 17, 2719, 4604, 4293, 18, 3]}, "items": [{"id": "p_3473", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3474", "content": "angiotensin [SEP] BACKGROUND: In man, differences in angiotensin-converting enzyme (ACE) levels, related to ACE (I/D) genotype, ", "tokenized_content": [2, 10814, 3, 3872, 30, 1922, 2323, 16, 2886, 1922, 10814, 17, 15025, 4113, 12, 8298, 13, 2428, 16, 2712, 1942, 8298, 12, 51, 19, 46, 13, 5619, 16, 3]}, "items": [{"id": "p_3474", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_3475", "content": "renal damage [SEP] the predictive effect of renal ACE activity for the severity of renal damage induced by a single injection of adriamycin in rats. METHODS: R", "tokenized_content": [2, 4604, 4293, 3, 1920, 6207, 2495, 1927, 4604, 8298, 2455, 1958, 1920, 5155, 1927, 4604, 4293, 2719, 2007, 43, 2957, 4107, 1927, 25622, 7898, 1922, 3615, 18, 2860, 30, 60, 3]}, "items": [{"id": "p_3475", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3476", "content": "adriamycin [SEP] r the severity of renal damage induced by a single injection of adriamycin in rats. METHODS: Renal ACE activity (Hip-His-Leu cleavage by c", "tokenized_content": [2, 25622, 7898, 3, 60, 1920, 5155, 1927, 4604, 4293, 2719, 2007, 43, 2957, 4107, 1927, 25622, 7898, 1922, 3615, 18, 2860, 30, 4604, 8298, 2455, 12, 7679, 17, 4167, 17, 3]}, "items": [{"id": "p_3476", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3477", "content": "Hip-His-Leu [SEP] e injection of adriamycin in rats. METHODS: Renal ACE activity (Hip-His-Leu cleavage by cortical homogenates) was determined by renal biops", "tokenized_content": [2, 7679, 17, 4167, 17, 10632, 3, 47, 4107, 1927, 25622, 7898, 1922, 3615, 18, 2860, 30, 4604, 8298, 2455, 12, 7679, 17, 4167, 17, 10632, 6404, 2007, 5586, 16773, 13, 3]}, "items": [{"id": "p_3477", "content": "hippuryl-histidyl-leucine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5266, 8605, 1024, 17, 27507, 14458, 1024, 17, 12624, 3, 3]}]}
{"query": {"id": "q_3478", "content": "proteinuria [SEP]  biopsy in 27 adult male Wistar rats. After 1 week of recovery, proteinuria was induced by adriamycin [1.5 mg/kg intravenously (i.v.) n = 1", "tokenized_content": [2, 15831, 3, 6831, 1922, 3225, 4160, 4005, 15668, 3615, 18, 2256, 21, 2982, 1927, 5241, 16, 15831, 1982, 2719, 2007, 25622, 7898, 37, 21, 18, 25, 2786, 19, 3621, 15132, 3]}, "items": [{"id": "p_3478", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_3479", "content": "Proteinuria [SEP] g/kg intravenously (i.v.) n = 18; controls, saline i.v. n = 9]. Proteinuria was measured every 2 weeks. After 12 weeks, rats were sacrifice", "tokenized_content": [2, 15831, 3, 49, 19, 3621, 15132, 12, 51, 18, 64, 18, 13, 56, 33, 2654, 31, 3562, 16, 5977, 51, 18, 64, 18, 56, 33, 29, 39, 18, 15831, 1982, 3]}, "items": [{"id": "p_3479", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_3480", "content": "nephrotic [SEP] kidneys harvested. RESULTS: As anticipated, adriamycin elicited nephrotic range proteinuria, renal interstitial damage and mild focal glo", "tokenized_content": [2, 29646, 3, 11770, 7509, 18, 2274, 30, 1966, 12909, 16, 25622, 7898, 9856, 29646, 3109, 15831, 16, 4604, 11584, 4293, 1930, 5809, 8083, 25632, 3]}, "items": [{"id": "p_3480", "content": "Nephrotic Syndrome [SEP] A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in ", "score": 1, "type": null, "tokenized_content": [2, 29646, 4741, 3, 43, 2625, 4378, 2007, 4010, 15831, 16, 3430, 2254, 23, 18, 25, 49, 19, 3007, 1922, 1925, 3361, 4160, 18, 1920, 6317, 3257, 1927, 2213, 1922, 3]}]}
{"query": {"id": "q_3481", "content": "renal interstitial damage [SEP] s anticipated, adriamycin elicited nephrotic range proteinuria, renal interstitial damage and mild focal glomerulosclerosis. Baseline renal ACE positivel", "tokenized_content": [2, 4604, 11584, 4293, 3, 61, 12909, 16, 25622, 7898, 9856, 29646, 3109, 15831, 16, 4604, 11584, 4293, 1930, 5809, 8083, 19268, 25081, 18, 3703, 4604, 8298, 2843, 1024, 3]}, "items": [{"id": "p_3481", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3482", "content": "focal glomerulosclerosis [SEP] nephrotic range proteinuria, renal interstitial damage and mild focal glomerulosclerosis. Baseline renal ACE positively correlated with the relative ris", "tokenized_content": [2, 8083, 19268, 25081, 3, 29646, 3109, 15831, 16, 4604, 11584, 4293, 1930, 5809, 8083, 19268, 25081, 18, 3703, 4604, 8298, 6629, 4374, 1956, 1920, 3338, 2511, 3]}, "items": [{"id": "p_3482", "content": "Glomerulosclerosis, Focal Segmental [SEP] A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary", "score": 1, "type": null, "tokenized_content": [2, 19268, 25081, 16, 8083, 16294, 3, 43, 17828, 4741, 2014, 4785, 2576, 1958, 43, 2601, 1927, 11655, 4047, 1988, 2258, 3137, 5092, 16, 3065, 2014, 4067, 3]}]}
{"query": {"id": "q_3483", "content": "nephrotoxicity [SEP] Clinical nephrotoxicity of tobramycin and gentamicin. A prospective study.", "tokenized_content": [2, 27880, 3, 2535, 27880, 1927, 7551, 29085, 4636, 1930, 17144, 18, 43, 6315, 2161, 18, 3]}, "items": [{"id": "p_3483", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3484", "content": "tobramycin [SEP] Clinical nephrotoxicity of tobramycin and gentamicin. A prospective study.", "tokenized_content": [2, 7551, 29085, 4636, 3, 2535, 27880, 1927, 7551, 29085, 4636, 1930, 17144, 18, 43, 6315, 2161, 18, 3]}, "items": [{"id": "p_3484", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_3485", "content": "gentamicin [SEP] Clinical nephrotoxicity of tobramycin and gentamicin. A prospective study.", "tokenized_content": [2, 17144, 3, 2535, 27880, 1927, 7551, 29085, 4636, 1930, 17144, 18, 43, 6315, 2161, 18, 3]}, "items": [{"id": "p_3485", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_3486", "content": "aminoglycoside [SEP] Nearly 3.2 million people in this country receive aminoglycoside antibiotics annually. Gentamicin sulfate and tobramycin sulfate", "tokenized_content": [2, 23029, 8028, 3, 6737, 23, 18, 22, 7068, 4329, 1922, 2052, 7722, 7130, 23029, 8028, 7560, 15495, 18, 17144, 8767, 1930, 7551, 29085, 4636, 8767, 3]}, "items": [{"id": "p_3486", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_3487", "content": "Gentamicin sulfate [SEP] le in this country receive aminoglycoside antibiotics annually. Gentamicin sulfate and tobramycin sulfate continue to demonstrate ototoxicity and ", "tokenized_content": [2, 17144, 8767, 3, 2071, 1922, 2052, 7722, 7130, 23029, 8028, 7560, 15495, 18, 17144, 8767, 1930, 7551, 29085, 4636, 8767, 9085, 1942, 4504, 7608, 11930, 1930, 3]}, "items": [{"id": "p_3487", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_3488", "content": "tobramycin sulfate [SEP] ive aminoglycoside antibiotics annually. Gentamicin sulfate and tobramycin sulfate continue to demonstrate ototoxicity and nephrotoxicity in both ", "tokenized_content": [2, 7551, 29085, 4636, 8767, 3, 4370, 1021, 23029, 8028, 7560, 15495, 18, 17144, 8767, 1930, 7551, 29085, 4636, 8767, 9085, 1942, 4504, 7608, 11930, 1930, 27880, 1922, 2321, 3]}, "items": [{"id": "p_3488", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_3489", "content": "ototoxicity [SEP] ntamicin sulfate and tobramycin sulfate continue to demonstrate ototoxicity and nephrotoxicity in both animal and clinical studies. In this", "tokenized_content": [2, 7608, 11930, 3, 20503, 4913, 1921, 8767, 1930, 7551, 29085, 4636, 8767, 9085, 1942, 4504, 7608, 11930, 1930, 27880, 1922, 2321, 4027, 1930, 2535, 2351, 18, 1922, 2052, 3]}, "items": [{"id": "p_3489", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_3490", "content": "nephrotoxicity [SEP]  and tobramycin sulfate continue to demonstrate ototoxicity and nephrotoxicity in both animal and clinical studies. In this study, 62 patients", "tokenized_content": [2, 27880, 3, 1930, 7551, 29085, 4636, 8767, 9085, 1942, 4504, 7608, 11930, 1930, 27880, 1922, 2321, 4027, 1930, 2535, 2351, 18, 1922, 2052, 2161, 16, 5374, 2132, 3]}, "items": [{"id": "p_3490", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3491", "content": "gentamicin sulfate [SEP] tial normal renal function and treated with 2 to 5 mg/kg/day of gentamicin sulfate or tobramycin sulfate for a minimum of seven days were followed", "tokenized_content": [2, 17144, 8767, 3, 22093, 1024, 2791, 4604, 2347, 1930, 2868, 1956, 22, 1942, 25, 2786, 19, 3621, 19, 3007, 1927, 17144, 8767, 2014, 7551, 29085, 4636, 8767, 1958, 43, 6081, 3]}, "items": [{"id": "p_3491", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_3492", "content": "renal failure [SEP]  up prospectively for the development of aminoglycoside-related renal failure, defined as at least a one-third reduction in renal function. I", "tokenized_content": [2, 4604, 4574, 3, 2353, 12439, 1958, 1920, 2740, 1927, 23029, 8028, 17, 2712, 4604, 4574, 16, 3608, 1966, 2019, 3464, 43, 2340, 17, 4563, 3378, 1922, 4604, 2347, 18, 51, 3]}, "items": [{"id": "p_3492", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_3493", "content": "tobramycin [SEP] ive aminoglycoside antibiotics annually. Gentamicin sulfate and tobramycin sulfate continue to demonstrate ototoxicity and nephrotoxicity ", "tokenized_content": [2, 7551, 29085, 4636, 3, 4370, 1021, 23029, 8028, 7560, 15495, 18, 17144, 8767, 1930, 7551, 29085, 4636, 8767, 9085, 1942, 4504, 7608, 11930, 1930, 27880, 3]}, "items": [{"id": "p_3493", "content": "Tobramycin [SEP] An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteri", "score": 1, "type": null, "tokenized_content": [2, 7551, 29085, 4636, 3, 1925, 23029, 8028, 16, 4949, 17, 5648, 7267, 4152, 2007, 22874, 5656, 13495, 5524, 3027, 1957, 18, 2176, 1977, 3655, 3316, 8604, 17, 3136, 14027, 3]}]}
{"query": {"id": "q_3494", "content": "gentamicin [SEP] tial normal renal function and treated with 2 to 5 mg/kg/day of gentamicin sulfate or tobramycin sulfate for a minimum of seven days were ", "tokenized_content": [2, 17144, 3, 22093, 1024, 2791, 4604, 2347, 1930, 2868, 1956, 22, 1942, 25, 2786, 19, 3621, 19, 3007, 1927, 17144, 8767, 2014, 7551, 29085, 4636, 8767, 1958, 43, 6081, 1927, 3]}, "items": [{"id": "p_3494", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_3495", "content": "MPEP [SEP] Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopa", "tokenized_content": [2, 5438, 2128, 3, 14345, 4615, 1927, 5438, 2128, 16, 43, 5328, 17495, 1015, 8151, 16, 1922, 20375, 17, 2719, 19428, 3]}, "items": [{"id": "p_3495", "content": "6-methyl-2-(phenylethynyl)pyridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26, 17, 4963, 17, 22, 17, 12, 26939, 28935, 16323, 1024, 13, 19604, 3, 3]}]}
{"query": {"id": "q_3496", "content": "methamphetamine [SEP] uroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decreas", "tokenized_content": [2, 20375, 3, 14984, 9218, 2451, 4615, 1927, 5438, 2128, 16, 43, 5328, 17495, 1015, 8151, 16, 1922, 20375, 17, 2719, 12214, 18034, 1977, 2458, 1956, 43, 2649, 1934, 3]}, "items": [{"id": "p_3496", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_3497", "content": "neurotoxicity [SEP] tive mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibitio", "tokenized_content": [2, 18034, 3, 8685, 1961, 17495, 1015, 8151, 16, 1922, 20375, 17, 2719, 12214, 18034, 1977, 2458, 1956, 43, 3714, 1922, 7964, 17792, 1930, 2875, 3940, 3]}, "items": [{"id": "p_3497", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3498", "content": "dopamine [SEP] MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine out", "tokenized_content": [2, 7964, 3, 5438, 2128, 16, 43, 5328, 17495, 1015, 8151, 16, 1922, 20375, 17, 2719, 12214, 18034, 1977, 2458, 1956, 43, 3714, 1922, 7964, 2397, 3]}, "items": [{"id": "p_3498", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3499", "content": "hyperthermia [SEP] ssociated with a decrease in dopamine outflow and inhibition of hyperthermia in rats.", "tokenized_content": [2, 21945, 3, 4577, 2240, 1981, 1956, 43, 3714, 1922, 7964, 17792, 1930, 3523, 1927, 21945, 1922, 3615, 18, 3]}, "items": [{"id": "p_3499", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_3500", "content": "glutamate [SEP] The aim of this study was to examine the role of metabotropic glutamate receptor 5 (mGluR5) in the toxic action of methamphetamine on d", "tokenized_content": [2, 7627, 3, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 5020, 1920, 2770, 1927, 18447, 8405, 7627, 3148, 25, 12, 17495, 1015, 13, 1922, 1920, 6161, 4615, 1927, 20375, 1990, 46, 3]}, "items": [{"id": "p_3500", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_3501", "content": "methamphetamine [SEP] tabotropic glutamate receptor 5 (mGluR5) in the toxic action of methamphetamine on dopaminergic neurones in rats. Methamphetamine (10 mg/kg sc)", "tokenized_content": [2, 20375, 3, 8514, 8405, 7627, 3148, 25, 12, 17495, 1015, 13, 1922, 1920, 6161, 4615, 1927, 20375, 1990, 12214, 25306, 1922, 3615, 18, 20375, 12, 2119, 2786, 19, 3621, 2160, 3]}, "items": [{"id": "p_3501", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_3502", "content": "Methamphetamine [SEP] xic action of methamphetamine on dopaminergic neurones in rats. Methamphetamine (10 mg/kg sc), administered five times, reduced the levels of d", "tokenized_content": [2, 20375, 3, 11551, 1030, 4615, 1927, 20375, 1990, 12214, 25306, 1922, 3615, 18, 20375, 12, 2119, 2786, 19, 3621, 2160, 13, 16, 5254, 3628, 3586, 16, 3028, 1920, 2428, 1927, 3]}, "items": [{"id": "p_3502", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_3503", "content": "dopamine [SEP] e receptor 5 (mGluR5) in the toxic action of methamphetamine on dopaminergic neurones in rats. Methamphetamine (10 mg/kg sc), administer", "tokenized_content": [2, 7964, 3, 47, 3148, 25, 12, 17495, 1015, 13, 1922, 1920, 6161, 4615, 1927, 20375, 1990, 12214, 25306, 1922, 3615, 18, 20375, 12, 2119, 2786, 19, 3621, 2160, 13, 16, 3]}, "items": [{"id": "p_3503", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3504", "content": "2-methyl-6-(phenylethynyl)pyridine [SEP] 2 h after the last injection. A selective antagonist of mGluR5, 2-methyl-6-(phenylethynyl)pyridine (MPEP; 5 mg/kg ip), when administered five times immediately be", "tokenized_content": [2, 22, 17, 4963, 17, 26, 17, 12, 26939, 28935, 16323, 1024, 13, 19604, 3, 22, 50, 2256, 1920, 4691, 4107, 18, 43, 5328, 8151, 1927, 17495, 1015, 16, 22, 17, 3]}, "items": [{"id": "p_3504", "content": "6-methyl-2-(phenylethynyl)pyridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26, 17, 4963, 17, 22, 17, 12, 26939, 28935, 16323, 1024, 13, 19604, 3, 3]}]}
{"query": {"id": "q_3505", "content": "MPEP [SEP] ctive antagonist of mGluR5, 2-methyl-6-(phenylethynyl)pyridine (MPEP; 5 mg/kg ip), when administered five times immediately before e", "tokenized_content": [2, 5438, 2128, 3, 3369, 2320, 8151, 1927, 17495, 1015, 16, 22, 17, 4963, 17, 26, 17, 12, 26939, 28935, 16323, 1024, 13, 19604, 12, 5438, 2128, 31, 25, 2786, 19, 3]}, "items": [{"id": "p_3505", "content": "6-methyl-2-(phenylethynyl)pyridine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26, 17, 4963, 17, 22, 17, 12, 26939, 28935, 16323, 1024, 13, 19604, 3, 3]}]}
{"query": {"id": "q_3506", "content": "veratridine [SEP] ethamphetamine (10 mg/kg sc) or by intrastriatally administered veratridine (100 microM). Moreover, it transiently diminished the methamphe", "tokenized_content": [2, 3566, 12078, 5802, 3, 3293, 18996, 12, 2119, 2786, 19, 3621, 2160, 13, 2014, 2007, 20362, 1997, 21195, 1954, 5254, 3566, 12078, 5802, 12, 2813, 7709, 13, 18, 3950, 16, 3]}, "items": [{"id": "p_3506", "content": "Veratridine [SEP] A benzoate-cevane found in VERATRUM and Schoenocaulon. It activates SODIUM CHANNELS to stay open longer than normal.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3566, 12078, 5802, 3, 43, 19225, 2010, 17, 5827, 25777, 1021, 2435, 1922, 3566, 12078, 1989, 1930, 2966, 6802, 11873, 3375, 1944, 1916, 18, 2176, 9094, 5227, 5628, 1942, 8094, 4437, 4872, 2254, 2791, 18, 3]}]}
{"query": {"id": "q_3507", "content": "hyperthermia [SEP] ransiently diminished the methamphetamine (10 mg/kg sc)-induced hyperthermia and reduced basal body temperature. MPEP administered into the ", "tokenized_content": [2, 21945, 3, 2845, 12924, 2512, 9597, 1920, 20375, 12, 2119, 2786, 19, 3621, 2160, 13, 17, 2719, 21945, 1930, 3028, 5342, 3362, 3449, 18, 5438, 2128, 5254, 2460, 1920, 3]}, "items": [{"id": "p_3507", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_3508", "content": "toxicity [SEP] y protect dopaminergic neurones against methamphetamine-induced toxicity. Neuroprotection rendered by MPEP may be associated with the re", "tokenized_content": [2, 5532, 3, 67, 9145, 12214, 25306, 3316, 20375, 17, 2719, 5532, 18, 21128, 18416, 2007, 5438, 2128, 2278, 1998, 2458, 1956, 1920, 1964, 3]}, "items": [{"id": "p_3508", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3509", "content": "desipramine HCl [SEP] Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl.", "tokenized_content": [2, 2270, 27085, 7833, 3, 14927, 1927, 2270, 27085, 7833, 2469, 5254, 1956, 10510, 10973, 8293, 1946, 7833, 18, 3]}, "items": [{"id": "p_3509", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_3510", "content": "cinacalcet HCl [SEP] Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl.", "tokenized_content": [2, 10510, 10973, 8293, 1946, 7833, 3, 14927, 1927, 2270, 27085, 7833, 2469, 5254, 1956, 10510, 10973, 8293, 1946, 7833, 18, 3]}, "items": [{"id": "p_3510", "content": "cinacalcet [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10510, 10973, 8293, 1946, 3, 3]}]}
{"query": {"id": "q_3511", "content": "cinacalcet [SEP] OBJECTIVE: In vitro work has demonstrated that cinacalcet is a strong inhibitor of cytochrome P450 isoenzyme (CYP) 2D6. T", "tokenized_content": [2, 10510, 10973, 8293, 1946, 3, 4470, 30, 1922, 3596, 2778, 2258, 3161, 1988, 10510, 10973, 8293, 1946, 1977, 43, 3206, 4106, 1927, 9387, 12088, 4911, 14896, 12, 6120, 13, 5941, 3]}, "items": [{"id": "p_3511", "content": "cinacalcet [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10510, 10973, 8293, 1946, 3, 3]}]}
{"query": {"id": "q_3512", "content": "desipramine [SEP]  to evaluate the effect of cinacalcet on CYP2D6 activity, using desipramine as a probe substrate, in healthy subjects. METHODS: Seventeen s", "tokenized_content": [2, 2270, 27085, 3, 1942, 4323, 1920, 2495, 1927, 10510, 10973, 8293, 1946, 1990, 24465, 2455, 16, 2193, 2270, 27085, 1966, 43, 5598, 4510, 16, 1922, 4097, 3297, 18, 2860, 30, 3]}, "items": [{"id": "p_3512", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_3513", "content": "nausea [SEP] ne with cinacalcet (33 versus 86%), the most frequent of which (nausea and headache) have been reported for patients treated with eith", "tokenized_content": [2, 13759, 3, 2069, 1956, 10510, 10973, 8293, 1946, 12, 3401, 4072, 5713, 9, 13, 16, 1920, 2501, 6439, 1927, 2154, 12, 13759, 1930, 12187, 13, 2162, 2252, 2568, 1958, 2132, 3]}, "items": [{"id": "p_3513", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_3514", "content": "headache [SEP] acalcet (33 versus 86%), the most frequent of which (nausea and headache) have been reported for patients treated with either desipramin", "tokenized_content": [2, 12187, 3, 18699, 8293, 1946, 12, 3401, 4072, 5713, 9, 13, 16, 1920, 2501, 6439, 1927, 2154, 12, 13759, 1930, 12187, 13, 2162, 2252, 2568, 1958, 2132, 2868, 1956, 3108, 3]}, "items": [{"id": "p_3514", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_3515", "content": "L-DOPA [SEP] Proteomic analysis of striatal proteins in the rat model of L-DOPA-induced dyskinesia.", "tokenized_content": [2, 54, 17, 19428, 3, 13492, 2333, 1927, 13165, 2697, 1922, 1920, 3067, 2322, 1927, 54, 17, 19428, 17, 2719, 3890, 26682, 18, 3]}, "items": [{"id": "p_3515", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_3516", "content": "dyskinesia [SEP] nalysis of striatal proteins in the rat model of L-DOPA-induced dyskinesia.", "tokenized_content": [2, 3890, 26682, 3, 13120, 4662, 1927, 13165, 2697, 1922, 1920, 3067, 2322, 1927, 54, 17, 19428, 17, 2719, 3890, 26682, 18, 3]}, "items": [{"id": "p_3516", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3517", "content": "L-DOPA [SEP] L-DOPA-induced dyskinesia (LID) is among the motor complications that ", "tokenized_content": [2, 54, 17, 19428, 3, 54, 17, 19428, 17, 2719, 3890, 26682, 12, 13096, 13, 1977, 2706, 1920, 4842, 5021, 1988, 3]}, "items": [{"id": "p_3517", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_3518", "content": "dyskinesia [SEP] L-DOPA-induced dyskinesia (LID) is among the motor complications that arise in Parkinson'", "tokenized_content": [2, 3890, 26682, 3, 54, 17, 19428, 17, 2719, 3890, 26682, 12, 13096, 13, 1977, 2706, 1920, 4842, 5021, 1988, 10149, 1922, 10124, 11, 3]}, "items": [{"id": "p_3518", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3519", "content": "LID [SEP] L-DOPA-induced dyskinesia (LID) is among the motor complications that arise in Parkinson's dis", "tokenized_content": [2, 13096, 3, 54, 17, 19428, 17, 2719, 3890, 26682, 12, 13096, 13, 1977, 2706, 1920, 4842, 5021, 1988, 10149, 1922, 10124, 11, 61, 2054, 3]}, "items": [{"id": "p_3519", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_3520", "content": "Parkinson's disease [SEP] dyskinesia (LID) is among the motor complications that arise in Parkinson's disease (PD) patients after a prolonged treatment with L-DOPA. To this ", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 3890, 26682, 12, 13096, 13, 1977, 2706, 1920, 4842, 5021, 1988, 10149, 1922, 10124, 11, 61, 2573, 12, 3203, 13, 2132, 2256, 43, 7171, 2311, 3]}, "items": [{"id": "p_3520", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_3521", "content": "PD [SEP] mong the motor complications that arise in Parkinson's disease (PD) patients after a prolonged treatment with L-DOPA. To this day,", "tokenized_content": [2, 3203, 3, 23659, 1920, 4842, 5021, 1988, 10149, 1922, 10124, 11, 61, 2573, 12, 3203, 13, 2132, 2256, 43, 7171, 2311, 1956, 54, 17, 19428, 18, 1942, 2052, 3007, 16, 3]}, "items": [{"id": "p_3521", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_3522", "content": "6-hydroxydopamine [SEP] rotein level in striatal samples obtained from the unilaterally 6-hydroxydopamine-lesion rat model of PD treated with saline, L-DOPA or bromocrip", "tokenized_content": [2, 26, 17, 8275, 22389, 4302, 25157, 3, 5337, 14818, 2237, 1922, 13165, 2785, 2926, 2037, 1920, 12059, 1954, 26, 17, 8275, 22389, 4302, 25157, 17, 5709, 3067, 2322, 1927, 3203, 3]}, "items": [{"id": "p_3522", "content": "Oxidopamine [SEP] A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in th", "score": 1, "type": null, "tokenized_content": [2, 3618, 8228, 25157, 3, 43, 15223, 12980, 1988, 27287, 1036, 27358, 14846, 1922, 5507, 17970, 1036, 1930, 6387, 43, 3378, 1927, 7964, 2428, 1922, 1913, 3]}]}
{"query": {"id": "q_3523", "content": "bromocriptine [SEP] ydopamine-lesion rat model of PD treated with saline, L-DOPA or bromocriptine using two-dimensional difference gel electrophoresis and mass s", "tokenized_content": [2, 21392, 4093, 2053, 3, 67, 22389, 4302, 25157, 17, 5709, 3067, 2322, 1927, 3203, 2868, 1956, 5977, 16, 54, 17, 19428, 2014, 21392, 4093, 2053, 2193, 2288, 17, 6477, 3175, 3]}, "items": [{"id": "p_3523", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_3524", "content": "allergic reactions [SEP] Pseudo-allergic reactions to corticosteroids: diagnosis and alternatives.", "tokenized_content": [2, 10519, 5298, 3, 11520, 17, 10519, 5298, 1942, 14610, 30, 3574, 1930, 15272, 18, 3]}, "items": [{"id": "p_3524", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_3525", "content": "corticosteroids [SEP] Pseudo-allergic reactions to corticosteroids: diagnosis and alternatives.", "tokenized_content": [2, 14610, 3, 11520, 17, 10519, 5298, 1942, 14610, 30, 3574, 1930, 15272, 18, 3]}, "items": [{"id": "p_3525", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_3526", "content": "paramethasone [SEP] Two patients treated with parenteral paramethasone (Triniol) and dexamethasone (Sedionbel) are described. A few mi", "tokenized_content": [2, 3167, 3184, 11718, 3, 2288, 2132, 2868, 1956, 20301, 3167, 3184, 11718, 12, 23501, 11149, 13, 1930, 12681, 12, 6276, 2001, 27237, 13, 2032, 2910, 18, 43, 3855, 6519, 3]}, "items": [{"id": "p_3526", "content": "Paramethasone [SEP] A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in", "score": 1, "type": null, "tokenized_content": [2, 3167, 3184, 11718, 3, 43, 14469, 1956, 1920, 3335, 3879, 1927, 14610, 18, 2176, 2258, 2252, 2251, 2007, 11701, 1922, 1920, 2311, 1927, 2136, 2961, 1922, 3]}]}
{"query": {"id": "q_3527", "content": "dexamethasone [SEP] wo patients treated with parenteral paramethasone (Triniol) and dexamethasone (Sedionbel) are described. A few minutes after administration o", "tokenized_content": [2, 12681, 3, 26334, 2132, 2868, 1956, 20301, 3167, 3184, 11718, 12, 23501, 11149, 13, 1930, 12681, 12, 6276, 2001, 27237, 13, 2032, 2910, 18, 43, 3855, 4814, 2256, 4183, 57, 3]}, "items": [{"id": "p_3527", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_3528", "content": "urticaria [SEP] A few minutes after administration of the drugs, they presented urticaria (patients 1 and 2) and conjunctivitis (patient 1). The purpose ", "tokenized_content": [2, 27986, 6148, 3, 43, 3855, 4814, 2256, 4183, 1927, 1920, 4195, 16, 2611, 3549, 27986, 6148, 12, 2132, 21, 1930, 22, 13, 1930, 16911, 3678, 12, 2774, 21, 13, 18, 3]}, "items": [{"id": "p_3528", "content": "Urticaria [SEP] A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability", "score": 1, "type": null, "tokenized_content": [2, 27986, 6148, 3, 43, 4541, 3227, 1927, 1920, 4407, 4378, 2007, 23349, 1930, 8372, 1923, 3337, 2810, 1942, 6579, 2760, 1927, 4541, 8828, 3]}]}
{"query": {"id": "q_3529", "content": "conjunctivitis [SEP] n of the drugs, they presented urticaria (patients 1 and 2) and conjunctivitis (patient 1). The purpose of our study was to determine the caus", "tokenized_content": [2, 16911, 3678, 3, 56, 1927, 1920, 4195, 16, 2611, 3549, 27986, 6148, 12, 2132, 21, 1930, 22, 13, 1930, 16911, 3678, 12, 2774, 21, 13, 18, 1920, 5120, 1927, 2342, 3]}, "items": [{"id": "p_3529", "content": "Conjunctivitis [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16911, 3678, 3, 3]}]}
{"query": {"id": "q_3530", "content": "corticosteroids [SEP] nations and skin, oral and parenteral challenges with different corticosteroids and ELISA tests were performed. In the two patients, skin and E", "tokenized_content": [2, 14610, 3, 18861, 1930, 4407, 16, 4726, 1930, 20301, 7321, 1956, 2413, 14610, 1930, 6977, 4026, 1985, 2593, 18, 1922, 1920, 2288, 2132, 16, 4407, 1930, 47, 3]}, "items": [{"id": "p_3530", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_3531", "content": "hypersensitivity [SEP] nts. Corticosteroids different from paramethasone also produced hypersensitivity reactions in these patients; however, a few of them were tolera", "tokenized_content": [2, 14625, 3, 17969, 18, 14610, 2413, 2037, 3167, 3184, 11718, 2222, 4152, 14625, 5298, 1922, 2144, 2132, 31, 2406, 16, 43, 3855, 1927, 3581, 1985, 4977, 1019, 3]}, "items": [{"id": "p_3531", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_3532", "content": "allergy [SEP] erstood. To our knowledge, this is the first report of a pseudo-allergy caused by paramethasone.", "tokenized_content": [2, 13255, 3, 22877, 4575, 1986, 18, 1942, 2342, 4163, 16, 2052, 1977, 1920, 2561, 3809, 1927, 43, 11520, 17, 13255, 4189, 2007, 3167, 3184, 11718, 18, 3]}, "items": [{"id": "p_3532", "content": "Drug Hypersensitivity [SEP] Immunologically mediated adverse reactions to medicinal substances used legally or illegally.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 14625, 3, 11611, 1954, 3434, 5246, 5298, 1942, 15033, 10054, 2251, 10348, 1954, 2014, 28313, 1954, 18, 3]}]}
{"query": {"id": "q_3533", "content": "Valproic acid [SEP] Valproic acid induced encephalopathy--19 new cases in Germany from 1994 to 20", "tokenized_content": [2, 23867, 1935, 2687, 3, 23867, 1935, 2687, 2719, 19393, 17, 17, 2282, 2814, 2919, 1922, 6205, 2037, 7319, 1942, 2036, 3]}, "items": [{"id": "p_3533", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_3534", "content": "encephalopathy [SEP] Valproic acid induced encephalopathy--19 new cases in Germany from 1994 to 2003--a side effect assoc", "tokenized_content": [2, 19393, 3, 23867, 1935, 2687, 2719, 19393, 17, 17, 2282, 2814, 2919, 1922, 6205, 2037, 7319, 1942, 4450, 17, 17, 43, 4159, 2495, 2088, 1994, 3]}, "items": [{"id": "p_3534", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3535", "content": "VPA [SEP] cases in Germany from 1994 to 2003--a side effect associated to VPA-therapy not only in young children.", "tokenized_content": [2, 19703, 3, 2919, 1922, 6205, 2037, 7319, 1942, 4450, 17, 17, 43, 4159, 2495, 2458, 1942, 19703, 17, 3181, 2084, 2444, 1922, 4201, 3069, 18, 3]}, "items": [{"id": "p_3535", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_3536", "content": "Valproic acid [SEP] Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually wel", "tokenized_content": [2, 23867, 1935, 2687, 3, 23867, 1935, 2687, 12, 19703, 13, 1977, 43, 4949, 17, 5648, 29132, 2838, 1930, 1977, 5394, 16302, 3]}, "items": [{"id": "p_3536", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_3537", "content": "VPA [SEP] Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually well-tol", "tokenized_content": [2, 19703, 3, 23867, 1935, 2687, 12, 19703, 13, 1977, 43, 4949, 17, 5648, 29132, 2838, 1930, 1977, 5394, 2486, 17, 21930, 3]}, "items": [{"id": "p_3537", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_3538", "content": "pancreatitis [SEP] omplications may occur in some patients, including haemorrhagic pancreatitis, bone marrow suppression, VPA-induced hepatotoxicity and VPA-in", "tokenized_content": [2, 14605, 3, 21921, 3742, 2082, 2278, 4704, 1922, 2673, 2132, 16, 2710, 18586, 12550, 14605, 16, 3622, 6599, 6412, 16, 19703, 17, 2719, 24126, 1930, 19703, 17, 1922, 3]}, "items": [{"id": "p_3538", "content": "Pancreatitis [SEP] INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde", "score": 1, "type": null, "tokenized_content": [2, 14605, 3, 4531, 1927, 1920, 10936, 18, 14605, 1977, 5947, 1966, 3939, 10292, 2276, 2032, 6287, 25035, 2014, 10448, 14492, 3]}]}
{"query": {"id": "q_3539", "content": "bone marrow suppression [SEP] ay occur in some patients, including haemorrhagic pancreatitis, bone marrow suppression, VPA-induced hepatotoxicity and VPA-induced encephalopathy. The", "tokenized_content": [2, 3622, 6599, 6412, 3, 15874, 4704, 1922, 2673, 2132, 16, 2710, 18586, 12550, 14605, 16, 3622, 6599, 6412, 16, 19703, 17, 2719, 24126, 1930, 19703, 17, 2719, 19393, 18, 1920, 3]}, "items": [{"id": "p_3539", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_3540", "content": "hepatotoxicity [SEP] haemorrhagic pancreatitis, bone marrow suppression, VPA-induced hepatotoxicity and VPA-induced encephalopathy. The typical signs of VPA-induce", "tokenized_content": [2, 24126, 3, 18586, 12550, 14605, 16, 3622, 6599, 6412, 16, 19703, 17, 2719, 24126, 1930, 19703, 17, 2719, 19393, 18, 1920, 5939, 6879, 1927, 19703, 17, 4769, 3]}, "items": [{"id": "p_3540", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3541", "content": "encephalopathy [SEP]  marrow suppression, VPA-induced hepatotoxicity and VPA-induced encephalopathy. The typical signs of VPA-induced encephalopathy are impaired c", "tokenized_content": [2, 19393, 3, 6599, 6412, 16, 19703, 17, 2719, 24126, 1930, 19703, 17, 2719, 19393, 18, 1920, 5939, 6879, 1927, 19703, 17, 2719, 19393, 2032, 5761, 45, 3]}, "items": [{"id": "p_3541", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3542", "content": "impaired consciousness [SEP] phalopathy. The typical signs of VPA-induced encephalopathy are impaired consciousness, sometimes marked EEG background slowing, increased seizure fre", "tokenized_content": [2, 5761, 16897, 3, 28752, 6522, 18, 1920, 5939, 6879, 1927, 19703, 17, 2719, 19393, 2032, 5761, 16897, 16, 8929, 4961, 9052, 3872, 20025, 16, 2502, 11015, 2805, 3]}, "items": [{"id": "p_3542", "content": "Consciousness Disorders [SEP] Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respon", "score": 1, "type": null, "tokenized_content": [2, 16897, 4414, 3, 6805, 5018, 4414, 1922, 2154, 2276, 1977, 6159, 1927, 1920, 3682, 1942, 6698, 8755, 1927, 3543, 1930, 3515, 1930, 1942, 2163, 1916, 3]}]}
{"query": {"id": "q_3543", "content": "seizure [SEP] nsciousness, sometimes marked EEG background slowing, increased seizure frequency, with or without hyperammonemia. There is still no pr", "tokenized_content": [2, 11015, 3, 18438, 4836, 2971, 16, 8929, 4961, 9052, 3872, 20025, 16, 2502, 11015, 3528, 16, 1956, 2014, 2979, 4194, 2595, 2290, 6026, 18, 2276, 1977, 3974, 2239, 2033, 3]}, "items": [{"id": "p_3543", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3544", "content": "hyperammonemia [SEP] ackground slowing, increased seizure frequency, with or without hyperammonemia. There is still no proof of causative effect of VPA in patients", "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 2000, 23254, 3049, 20025, 16, 2502, 11015, 3528, 16, 1956, 2014, 2979, 4194, 2595, 2290, 6026, 18, 2276, 1977, 3974, 2239, 10034, 1927, 13939, 2495, 3]}, "items": [{"id": "p_3544", "content": "Hyperammonemia [SEP] Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 2595, 2290, 6026, 3, 4664, 2237, 1927, 14880, 1922, 1920, 2877, 18, 2176, 1977, 43, 2105, 1927, 9785, 19480, 1927, 3835, 4576, 2014, 14880, 1942, 10505, 18, 3]}]}
{"query": {"id": "q_3545", "content": "Haemolytic-uraemic syndrome [SEP] Haemolytic-uraemic syndrome after treatment with metronidazole.", "tokenized_content": [2, 7105, 6586, 17, 3674, 16894, 4741, 3, 7105, 6586, 17, 3674, 16894, 4741, 2256, 2311, 1956, 26402, 18, 3]}, "items": [{"id": "p_3545", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_3546", "content": "metronidazole [SEP] Haemolytic-uraemic syndrome after treatment with metronidazole.", "tokenized_content": [2, 26402, 3, 7105, 6586, 17, 3674, 16894, 4741, 2256, 2311, 1956, 26402, 18, 3]}, "items": [{"id": "p_3546", "content": "Metronidazole [SEP] A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFE", "score": 1, "type": null, "tokenized_content": [2, 26402, 3, 43, 8686, 28950, 2251, 1942, 2297, 2150, 13495, 11550, 31, 7715, 11566, 3600, 31, 10477, 10480, 5024, 31, 7217, 13047, 8362, 31, 12554, 4802, 31, 1930, 2171, 21851, 30426, 2122, 1021, 3]}]}
{"query": {"id": "q_3547", "content": "haemolytic-uraemic syndrome [SEP] scribes the clinical features of six children who developed the haemolytic-uraemic syndrome after treatment with metronidazole. These children were older a", "tokenized_content": [2, 7105, 6586, 17, 3674, 16894, 4741, 3, 7572, 2023, 1918, 1920, 2535, 4075, 1927, 3798, 3069, 2746, 3530, 1920, 7105, 6586, 17, 3674, 16894, 4741, 2256, 2311, 1956, 26402, 18, 3]}, "items": [{"id": "p_3547", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_3548", "content": "metronidazole [SEP]  developed the haemolytic-uraemic syndrome after treatment with metronidazole. These children were older and were more likely to have undergo", "tokenized_content": [2, 26402, 3, 3530, 1920, 7105, 6586, 17, 3674, 16894, 4741, 2256, 2311, 1956, 26402, 18, 2144, 3069, 1985, 4706, 1930, 1985, 2253, 3205, 1942, 2162, 4978, 3]}, "items": [{"id": "p_3548", "content": "Metronidazole [SEP] A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFE", "score": 1, "type": null, "tokenized_content": [2, 26402, 3, 43, 8686, 28950, 2251, 1942, 2297, 2150, 13495, 11550, 31, 7715, 11566, 3600, 31, 10477, 10480, 5024, 31, 7217, 13047, 8362, 31, 12554, 4802, 31, 1930, 2171, 21851, 30426, 2122, 1021, 3]}]}
{"query": {"id": "q_3549", "content": "sensorineural hearing loss [SEP] Risk factors of sensorineural hearing loss in preterm infants.", "tokenized_content": [2, 6443, 2053, 2741, 8512, 3257, 3, 2565, 2790, 1927, 6443, 2053, 2741, 8512, 3257, 1922, 10435, 5969, 18, 3]}, "items": [{"id": "p_3549", "content": "Hearing Loss, Sensorineural [SEP] Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 6443, 2053, 2741, 3, 8512, 3257, 3864, 2037, 4293, 1942, 1920, 23310, 1930, 1920, 6443, 2053, 2741, 5362, 2154, 14958, 23125, 6844, 1920, 22584, 1930, 7464, 3]}]}
{"query": {"id": "q_3550", "content": "sensorineural hearing loss [SEP] , 8 children (1.46%) developed severe progressive and bilateral sensorineural hearing loss. Perinatal risk factors of infants with hearing loss were compa", "tokenized_content": [2, 6443, 2053, 2741, 8512, 3257, 3, 16, 28, 3069, 12, 21, 18, 4182, 9, 13, 3530, 4010, 7529, 1930, 7787, 6443, 2053, 2741, 8512, 3257, 18, 13833, 2565, 2790, 1927, 3]}, "items": [{"id": "p_3550", "content": "Hearing Loss, Sensorineural [SEP] Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 6443, 2053, 2741, 3, 8512, 3257, 3864, 2037, 4293, 1942, 1920, 23310, 1930, 1920, 6443, 2053, 2741, 5362, 2154, 14958, 23125, 6844, 1920, 22584, 1930, 7464, 3]}]}
{"query": {"id": "q_3551", "content": "hearing loss [SEP] 1.46%) developed severe progressive and bilateral sensorineural hearing loss. Perinatal risk factors of infants with hearing loss were compa", "tokenized_content": [2, 8512, 3257, 3, 21, 18, 4182, 9, 13, 3530, 4010, 7529, 1930, 7787, 6443, 2053, 2741, 8512, 3257, 18, 13833, 2565, 2790, 1927, 5969, 1956, 8512, 3257, 1985, 2059, 1019, 3]}, "items": [{"id": "p_3551", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_3552", "content": "Ototoxicity [SEP] earing loss with a higher incidence of perinatal complications. Ototoxicity appeared closely related to a prolonged administration and high", "tokenized_content": [2, 7608, 11930, 3, 4352, 1941, 3257, 1956, 43, 2580, 4332, 1927, 13833, 5021, 18, 7608, 11930, 6209, 6538, 2712, 1942, 43, 7171, 4183, 1930, 2149, 3]}, "items": [{"id": "p_3552", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_3553", "content": "ototoxic [SEP]  related to a prolonged administration and higher total dose of ototoxic drugs, particularly aminoglycosides and furosemide. Finally, we", "tokenized_content": [2, 7608, 12899, 3, 2712, 1942, 43, 7171, 4183, 1930, 2580, 2698, 3253, 1927, 7608, 12899, 4195, 16, 4443, 23029, 17079, 1930, 30509, 18, 4342, 16, 2038, 3]}, "items": [{"id": "p_3553", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_3554", "content": "aminoglycosides [SEP] istration and higher total dose of ototoxic drugs, particularly aminoglycosides and furosemide. Finally, we strongly recommend to prospectively", "tokenized_content": [2, 23029, 17079, 3, 1977, 6003, 1930, 2580, 2698, 3253, 1927, 7608, 12899, 4195, 16, 4443, 23029, 17079, 1930, 30509, 18, 4342, 16, 2038, 4937, 5732, 1942, 12439, 3]}, "items": [{"id": "p_3554", "content": "Aminoglycosides [SEP] Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTIC", "score": 1, "type": null, "tokenized_content": [2, 23029, 17079, 3, 17514, 4300, 1922, 2154, 2276, 1977, 1925, 3835, 23709, 1990, 1920, 7533, 2261, 18, 2673, 1927, 3581, 2032, 5908, 2715, 7267, 3]}]}
{"query": {"id": "q_3555", "content": "furosemide [SEP]  total dose of ototoxic drugs, particularly aminoglycosides and furosemide. Finally, we strongly recommend to prospectively and regularly ", "tokenized_content": [2, 30509, 3, 2698, 3253, 1927, 7608, 12899, 4195, 16, 4443, 23029, 17079, 1930, 30509, 18, 4342, 16, 2038, 4937, 5732, 1942, 12439, 1930, 13487, 3]}, "items": [{"id": "p_3555", "content": "Furosemide [SEP] A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFF", "score": 1, "type": null, "tokenized_content": [2, 30509, 3, 43, 19225, 1935, 17, 26265, 5482, 17, 28028, 1022, 18, 2176, 1977, 43, 26829, 1956, 5867, 4727, 1930, 3662, 4392, 1988, 1977, 2251, 1958, 10144, 1930, 3724, 4604, 7697, 2040, 3]}]}
{"query": {"id": "q_3556", "content": "cimetidine [SEP] Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusion.", "tokenized_content": [2, 20090, 4988, 27099, 3, 12763, 1930, 2535, 2351, 1922, 2132, 1956, 20090, 4988, 27099, 17, 2458, 5018, 18272, 18, 3]}, "items": [{"id": "p_3556", "content": "Cimetidine [SEP] A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacol", "score": 1, "type": null, "tokenized_content": [2, 20090, 4988, 27099, 3, 43, 14622, 8680, 1915, 16, 2176, 10362, 1954, 7042, 14622, 2743, 1942, 14622, 4881, 4086, 18, 20090, 4988, 27099, 2258, 43, 3109, 1927, 22543, 3]}]}
{"query": {"id": "q_3557", "content": "confusion [SEP]  clinical studies in patients with cimetidine-associated mental confusion.", "tokenized_content": [2, 18272, 3, 2535, 2351, 1922, 2132, 1956, 20090, 4988, 27099, 17, 2458, 5018, 18272, 18, 3]}, "items": [{"id": "p_3557", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_3558", "content": "cimetidine [SEP] 15 cases of cimetidine-associated mental confusion have been reported. In order that t", "tokenized_content": [2, 20090, 4988, 27099, 3, 2461, 2919, 1927, 20090, 4988, 27099, 17, 2458, 5018, 18272, 2162, 2252, 2568, 18, 1922, 3238, 1988, 62, 3]}, "items": [{"id": "p_3558", "content": "Cimetidine [SEP] A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacol", "score": 1, "type": null, "tokenized_content": [2, 20090, 4988, 27099, 3, 43, 14622, 8680, 1915, 16, 2176, 10362, 1954, 7042, 14622, 2743, 1942, 14622, 4881, 4086, 18, 20090, 4988, 27099, 2258, 43, 3109, 1927, 22543, 3]}]}
{"query": {"id": "q_3559", "content": "confusion [SEP] 15 cases of cimetidine-associated mental confusion have been reported. In order that this syndrome might be invest", "tokenized_content": [2, 18272, 3, 2461, 2919, 1927, 20090, 4988, 27099, 17, 2458, 5018, 18272, 2162, 2252, 2568, 18, 1922, 3238, 1988, 2052, 4741, 3284, 1998, 12476, 3]}, "items": [{"id": "p_3559", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_3560", "content": "liver dysfunction [SEP] moderate to severe changes. These 6 patients had both renal and liver dysfunction (P less than 0.05), as well as cimetidine trough-concentrations", "tokenized_content": [2, 3568, 5273, 3, 5086, 1942, 4010, 2840, 18, 2144, 26, 2132, 2430, 2321, 4604, 1930, 3568, 5273, 12, 58, 2941, 2254, 20, 18, 2914, 13, 16, 1966, 2486, 1966, 20090, 3]}, "items": [{"id": "p_3560", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3561", "content": "histamine [SEP] raises the possibility that M.S. changes are due to blockade of histamine H2-receptors in the central nervous system. Patients likely to ", "tokenized_content": [2, 14622, 3, 14086, 1920, 5341, 1988, 55, 18, 61, 18, 2840, 2032, 2810, 1942, 9847, 1927, 14622, 4881, 17, 4086, 1922, 1920, 4101, 7580, 2433, 18, 2132, 3205, 1942, 3]}, "items": [{"id": "p_3561", "content": "Histamine [SEP] An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of br", "score": 1, "type": null, "tokenized_content": [2, 14622, 3, 1925, 13610, 3595, 2007, 8145, 22429, 1943, 1927, 13873, 18, 2176, 1977, 43, 9974, 24252, 1927, 6319, 5512, 16, 43, 15595, 2684, 1927, 2387, 3]}]}
{"query": {"id": "q_3562", "content": "hepatic dysfunction [SEP] tions and mental confusion are those with both severe renal and hepatic dysfunction. They should be closely observed and should be given reduced do", "tokenized_content": [2, 6095, 5273, 3, 8685, 2101, 1930, 5018, 18272, 2032, 2690, 1956, 2321, 4010, 4604, 1930, 6095, 5273, 18, 2611, 3066, 1998, 6538, 2528, 1930, 3066, 1998, 3258, 3028, 2608, 3]}, "items": [{"id": "p_3562", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3563", "content": "extrahepatic cholestasis [SEP] ed hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis.", "tokenized_content": [2, 29086, 30086, 3, 3347, 14675, 8246, 11245, 1922, 3067, 3130, 1927, 22323, 1930, 29086, 30086, 18, 3]}, "items": [{"id": "p_3563", "content": "Cholestasis, Extrahepatic [SEP] Impairment of bile flow in the large BILE DUCTS by mechanical obstruction or stricture due to benign or malignant processes.\n   ", "score": 1, "type": null, "tokenized_content": [2, 30086, 16, 29086, 3, 6159, 1927, 9619, 3426, 1922, 1920, 3103, 9619, 19277, 2007, 5821, 10849, 2014, 25679, 2810, 1942, 8867, 2014, 6558, 4028, 18, 3]}]}
{"query": {"id": "q_3564", "content": "cholestasis [SEP] role in bile formation. Although hepatocyte TJs are impaired in cholestasis, attempts to localize the precise site of hepatocyte TJ damage ", "tokenized_content": [2, 30086, 3, 2770, 1922, 9619, 3337, 18, 2876, 14675, 17904, 1036, 2032, 5761, 1922, 30086, 16, 9866, 1942, 14380, 1920, 8162, 3200, 1927, 14675, 17904, 4293, 3]}, "items": [{"id": "p_3564", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3565", "content": "intrahepatic cholestasis [SEP] correlate with paracellular permeability. We used rat models of intrahepatic cholestasis by ethinyl estradiol (EE) treatment and extrahepatic cholestasi", "tokenized_content": [2, 22323, 30086, 3, 8474, 1956, 13344, 3386, 8828, 18, 2038, 2251, 3067, 3130, 1927, 22323, 30086, 2007, 17180, 16323, 1024, 11513, 12, 11150, 13, 2311, 1930, 29086, 21211, 13130, 3]}, "items": [{"id": "p_3565", "content": "Cholestasis, Intrahepatic [SEP] Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPA", "score": 1, "type": null, "tokenized_content": [2, 30086, 16, 22323, 3, 6159, 1927, 9619, 3426, 2810, 1942, 4047, 1942, 1920, 9919, 31, 9619, 11152, 16058, 1033, 31, 2014, 1920, 22323, 9619, 19277, 12, 9619, 19277, 16, 5153, 4116, 4302, 3]}]}
{"query": {"id": "q_3566", "content": "ethinyl estradiol [SEP] permeability. We used rat models of intrahepatic cholestasis by ethinyl estradiol (EE) treatment and extrahepatic cholestasis by bile duct ligati", "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 8828, 18, 2038, 2251, 3067, 3130, 1927, 22323, 30086, 2007, 17180, 16323, 1024, 11513, 12, 11150, 13, 2311, 1930, 29086, 30086, 2007, 9619, 10840, 3650, 3]}, "items": [{"id": "p_3566", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_3567", "content": "EE [SEP] ed rat models of intrahepatic cholestasis by ethinyl estradiol (EE) treatment and extrahepatic cholestasis by bile duct ligation (", "tokenized_content": [2, 11150, 3, 3347, 3067, 3130, 1927, 22323, 30086, 2007, 17180, 16323, 1024, 11513, 12, 11150, 13, 2311, 1930, 29086, 30086, 2007, 9619, 10840, 11102, 12, 3]}, "items": [{"id": "p_3567", "content": "Ethinyl Estradiol [SEP] A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orall", "score": 1, "type": null, "tokenized_content": [2, 17180, 16323, 1024, 11513, 3, 43, 8762, 18801, 4905, 4116, 2002, 13345, 1981, 11513, 1956, 43, 2752, 17, 4595, 17, 17180, 16323, 1024, 6636, 18, 2176, 2258, 2149, 29345, 10397, 2469, 5254, 4726, 1024, 3]}]}
{"query": {"id": "q_3568", "content": "extrahepatic cholestasis [SEP] ntrahepatic cholestasis by ethinyl estradiol (EE) treatment and extrahepatic cholestasis by bile duct ligation (BDL) to precisely determine the site of ", "tokenized_content": [2, 29086, 30086, 3, 20517, 5945, 15974, 30086, 2007, 17180, 16323, 1024, 11513, 12, 11150, 13, 2311, 1930, 29086, 30086, 2007, 9619, 10840, 11102, 12, 5238, 1024, 13, 1942, 12565, 3415, 3]}, "items": [{"id": "p_3568", "content": "Cholestasis, Extrahepatic [SEP] Impairment of bile flow in the large BILE DUCTS by mechanical obstruction or stricture due to benign or malignant processes.\n   ", "score": 1, "type": null, "tokenized_content": [2, 30086, 16, 29086, 3, 6159, 1927, 9619, 3426, 1922, 1920, 3103, 9619, 19277, 2007, 5821, 10849, 2014, 25679, 2810, 1942, 8867, 2014, 6558, 4028, 18, 3]}]}
{"query": {"id": "q_3569", "content": "beta-thalassemic [SEP] Long term audiological evaluation of beta-thalassemic patients.", "tokenized_content": [2, 4666, 17, 20338, 4197, 3, 2815, 2576, 18609, 22284, 2046, 4391, 1927, 4666, 17, 20338, 4197, 2132, 18, 3]}, "items": [{"id": "p_3569", "content": "beta-Thalassemia [SEP] A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis i", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 24959, 3, 43, 4770, 4378, 2007, 3028, 4271, 1927, 1920, 4666, 7835, 1927, 9652, 18, 2276, 1977, 16342, 1927, 9652, 43, 4271, 51, 3]}]}
{"query": {"id": "q_3570", "content": "hearing loss [SEP] was to identify the incidence and to monitor the progression of hearing loss in children and young adults with beta-thalassemia major. METHO", "tokenized_content": [2, 8512, 3257, 3, 1982, 1942, 3512, 1920, 4332, 1930, 1942, 8434, 1920, 4380, 1927, 8512, 3257, 1922, 3069, 1930, 4201, 4440, 1956, 4666, 17, 24959, 3044, 18, 2295, 1037, 3]}, "items": [{"id": "p_3570", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_3571", "content": "beta-thalassemia [SEP] e progression of hearing loss in children and young adults with beta-thalassemia major. METHODS: One hundred and four (104) patients aged 6-35 y", "tokenized_content": [2, 4666, 17, 24959, 3, 47, 4380, 1927, 8512, 3257, 1922, 3069, 1930, 4201, 4440, 1956, 4666, 17, 24959, 3044, 18, 2860, 30, 2340, 8295, 1930, 3006, 12, 8824, 13, 2132, 3]}, "items": [{"id": "p_3571", "content": "beta-Thalassemia [SEP] A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis i", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 24959, 3, 43, 4770, 4378, 2007, 3028, 4271, 1927, 1920, 4666, 7835, 1927, 9652, 18, 2276, 1977, 16342, 1927, 9652, 43, 4271, 51, 3]}]}
{"query": {"id": "q_3572", "content": "desferrioxamine [SEP] g a mean hemoglobin level of 9.5 gr/dl. Subjects were receiving desferrioxamine (DFO) chelation treatment with a mean daily dose of 50-60 mg/kg", "tokenized_content": [2, 2270, 2070, 19481, 11414, 25157, 3, 49, 43, 2667, 9652, 2237, 1927, 29, 18, 25, 2398, 19, 5268, 18, 3297, 1985, 5962, 2270, 2070, 19481, 11414, 25157, 12, 8122, 1037, 3]}, "items": [{"id": "p_3572", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_3573", "content": "DFO [SEP] in level of 9.5 gr/dl. Subjects were receiving desferrioxamine (DFO) chelation treatment with a mean daily dose of 50-60 mg/kg, 5-6", "tokenized_content": [2, 8122, 1037, 3, 1922, 2237, 1927, 29, 18, 25, 2398, 19, 5268, 18, 3297, 1985, 5962, 2270, 2070, 19481, 11414, 25157, 12, 8122, 1037, 13, 28526, 2311, 1956, 43, 2667, 3]}, "items": [{"id": "p_3573", "content": "Deferoxamine [SEP] Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in th", "score": 1, "type": null, "tokenized_content": [2, 20519, 2325, 3812, 3, 4613, 4863, 3937, 2037, 22874, 7547, 13650, 18, 2176, 4952, 5680, 5048, 1930, 1977, 2251, 1966, 43, 25814, 5899, 16, 4443, 1922, 1913, 3]}]}
{"query": {"id": "q_3574", "content": "sensorineural hearing loss [SEP] l, 21 out of 104 patients (20.2%) presented with high frequency sensorineural hearing loss (SNHL), either unilateral or bilateral. No ototoxic factor, oth", "tokenized_content": [2, 6443, 2053, 2741, 8512, 3257, 3, 54, 16, 2900, 2397, 1927, 8824, 2132, 12, 2036, 18, 22, 9, 13, 3549, 1956, 2149, 3528, 6443, 2053, 2741, 8512, 3257, 12, 3437, 3]}, "items": [{"id": "p_3574", "content": "Hearing Loss, Sensorineural [SEP] Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 6443, 2053, 2741, 3, 8512, 3257, 3864, 2037, 4293, 1942, 1920, 23310, 1930, 1920, 6443, 2053, 2741, 5362, 2154, 14958, 23125, 6844, 1920, 22584, 1930, 7464, 3]}]}
{"query": {"id": "q_3575", "content": "SNHL [SEP] 0.2%) presented with high frequency sensorineural hearing loss (SNHL), either unilateral or bilateral. No ototoxic factor, other tha", "tokenized_content": [2, 3437, 7806, 3, 20, 18, 22, 9, 13, 3549, 1956, 2149, 3528, 6443, 2053, 2741, 8512, 3257, 12, 3437, 7806, 13, 16, 3108, 12059, 2014, 7787, 18, 2239, 7608, 12899, 3]}, "items": [{"id": "p_3575", "content": "Hearing Loss, Sensorineural [SEP] Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 16, 6443, 2053, 2741, 3, 8512, 3257, 3864, 2037, 4293, 1942, 1920, 23310, 1930, 1920, 6443, 2053, 2741, 5362, 2154, 14958, 23125, 6844, 1920, 22584, 1930, 7464, 3]}]}
{"query": {"id": "q_3576", "content": "ototoxic [SEP] ineural hearing loss (SNHL), either unilateral or bilateral. No ototoxic factor, other than DFO, was present in any of the patients. Pat", "tokenized_content": [2, 7608, 12899, 3, 11116, 2741, 8512, 3257, 12, 3437, 7806, 13, 16, 3108, 12059, 2014, 7787, 18, 2239, 7608, 12899, 2991, 16, 2303, 2254, 8122, 1037, 16, 1982, 2481, 1922, 3]}, "items": [{"id": "p_3576", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_3577", "content": "hearing impairment [SEP] are indicative of DFO's contributing role in the development of hearing impairment. Regular audiologic evaluation is imperative in all thalassemic", "tokenized_content": [2, 8512, 6159, 3, 2032, 10779, 1927, 8122, 1037, 11, 61, 8739, 2770, 1922, 1920, 2740, 1927, 8512, 6159, 18, 6314, 18609, 22284, 1935, 4391, 1977, 20107, 1922, 2136, 20338, 4197, 3]}, "items": [{"id": "p_3577", "content": "Hearing Loss [SEP] A general term for the complete or partial loss of the ability to hear from one or both ears.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8512, 3257, 3, 43, 3335, 2576, 1958, 1920, 4080, 2014, 5740, 3257, 1927, 1920, 3682, 1942, 3563, 2037, 2340, 2014, 2321, 19332, 18, 3]}]}
{"query": {"id": "q_3578", "content": "thalassemic [SEP]  impairment. Regular audiologic evaluation is imperative in all thalassemic patients so that early changes may be recognized and treatment ", "tokenized_content": [2, 20338, 4197, 3, 6159, 18, 6314, 18609, 22284, 1935, 4391, 1977, 20107, 1922, 2136, 20338, 4197, 2132, 2577, 1988, 3120, 2840, 2278, 1998, 6783, 1930, 2311, 3]}, "items": [{"id": "p_3578", "content": "Thalassemia [SEP] A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. Ther", "score": 1, "type": null, "tokenized_content": [2, 24959, 3, 43, 2210, 1927, 16321, 21515, 10679, 1036, 1922, 2154, 2276, 1977, 3261, 4271, 1927, 2340, 2014, 2253, 9652, 13022, 7835, 18, 2704, 3]}]}
{"query": {"id": "q_3579", "content": "enalapril [SEP] Design and analysis of the HYPREN-trial: safety of enalapril and prazosin in the initial treatment phase of patients with co", "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 3036, 1930, 2333, 1927, 1920, 2483, 2825, 17, 3046, 30, 5407, 1927, 2066, 8056, 2047, 1970, 1930, 29041, 5872, 1922, 1920, 3754, 2311, 3193, 1927, 3]}, "items": [{"id": "p_3579", "content": "Enalapril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 1988, 1977, 2251, 1942, 2297, 5579, 18, 3]}]}
{"query": {"id": "q_3580", "content": "prazosin [SEP] esign and analysis of the HYPREN-trial: safety of enalapril and prazosin in the initial treatment phase of patients with congestive hear", "tokenized_content": [2, 29041, 5872, 3, 11575, 3223, 1930, 2333, 1927, 1920, 2483, 2825, 17, 3046, 30, 5407, 1927, 2066, 8056, 2047, 1970, 1930, 29041, 5872, 1922, 1920, 3754, 2311, 3193, 1927, 2132, 3]}, "items": [{"id": "p_3580", "content": "Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS", "score": 1, "type": null, "tokenized_content": [2, 29041, 5872, 3, 43, 5328, 13672, 4595, 17, 21, 8151, 2251, 1922, 1920, 2311, 1927, 4003, 4574, 31, 5579, 31, 30004, 26493, 31, 6451, 2175, 2009, 2445, 1934, 3]}]}
{"query": {"id": "q_3581", "content": "congestive heart failure [SEP] il and prazosin in the initial treatment phase of patients with congestive heart failure.", "tokenized_content": [2, 20180, 4003, 4574, 3, 2614, 1930, 29041, 5872, 1922, 1920, 3754, 2311, 3193, 1927, 2132, 1956, 20180, 4003, 4574, 18, 3]}, "items": [{"id": "p_3581", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_3582", "content": "angiotensin converting enzyme (ACE) inhibitors [SEP] Since the introduction of angiotensin converting enzyme (ACE) inhibitors into the adjunctive treatment of patients with congestive heart", "tokenized_content": [2, 10814, 15025, 4113, 12, 8298, 13, 4472, 3, 3328, 1920, 6935, 1927, 10814, 15025, 4113, 12, 8298, 13, 4472, 2460, 1920, 24017, 2311, 1927, 2132, 1956, 20180, 4003, 3]}, "items": [{"id": "p_3582", "content": "Angiotensin-Converting Enzyme Inhibitors [SEP] A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect", "score": 1, "type": null, "tokenized_content": [2, 10814, 17, 15025, 4113, 4472, 3, 43, 2921, 1927, 4195, 6098, 2730, 11615, 2032, 1920, 2311, 1927, 5579, 1930, 4003, 4574, 18, 2611, 10788, 2310, 12173, 2495, 3]}]}
{"query": {"id": "q_3583", "content": "congestive heart failure [SEP] (ACE) inhibitors into the adjunctive treatment of patients with congestive heart failure, cases of severe hypotension, especially on the first day of tr", "tokenized_content": [2, 20180, 4003, 4574, 3, 12, 8298, 13, 4472, 2460, 1920, 24017, 2311, 1927, 2132, 1956, 20180, 4003, 4574, 16, 2919, 1927, 4010, 16453, 16, 4369, 1990, 1920, 2561, 3007, 1927, 3]}, "items": [{"id": "p_3583", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_3584", "content": "hypotension [SEP] ment of patients with congestive heart failure, cases of severe hypotension, especially on the first day of treatment, have occasionally be", "tokenized_content": [2, 16453, 3, 11567, 1927, 2132, 1956, 20180, 4003, 4574, 16, 2919, 1927, 4010, 16453, 16, 4369, 1990, 1920, 2561, 3007, 1927, 2311, 16, 2162, 14647, 1998, 3]}, "items": [{"id": "p_3584", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3585", "content": "ACE inhibitor [SEP] t, have occasionally been reported. To assess the safety of the ACE inhibitor enalapril a multicenter, randomized, prazosin-controlled trial ", "tokenized_content": [2, 8298, 4106, 3, 62, 16, 2162, 14647, 2252, 2568, 18, 1942, 2634, 1920, 5407, 1927, 1920, 8298, 4106, 2066, 8056, 2047, 1970, 43, 14620, 16, 5542, 16, 29041, 5872, 17, 3]}, "items": [{"id": "p_3585", "content": "Angiotensin-Converting Enzyme Inhibitors [SEP] A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect", "score": 1, "type": null, "tokenized_content": [2, 10814, 17, 15025, 4113, 4472, 3, 43, 2921, 1927, 4195, 6098, 2730, 11615, 2032, 1920, 2311, 1927, 5579, 1930, 4003, 4574, 18, 2611, 10788, 2310, 12173, 2495, 3]}]}
{"query": {"id": "q_3586", "content": "enalapril [SEP] onally been reported. To assess the safety of the ACE inhibitor enalapril a multicenter, randomized, prazosin-controlled trial was design", "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 1990, 2169, 2252, 2568, 18, 1942, 2634, 1920, 5407, 1927, 1920, 8298, 4106, 2066, 8056, 2047, 1970, 43, 14620, 16, 5542, 16, 29041, 5872, 17, 3]}, "items": [{"id": "p_3586", "content": "Enalapril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 1988, 1977, 2251, 1942, 2297, 5579, 18, 3]}]}
{"query": {"id": "q_3587", "content": "prazosin [SEP] afety of the ACE inhibitor enalapril a multicenter, randomized, prazosin-controlled trial was designed that compared the incidence and s", "tokenized_content": [2, 29041, 5872, 3, 2221, 3152, 1927, 1920, 8298, 4106, 2066, 8056, 2047, 1970, 43, 14620, 16, 5542, 16, 29041, 5872, 17, 4642, 3046, 1982, 4609, 1988, 2452, 1920, 4332, 1930, 3]}, "items": [{"id": "p_3587", "content": "Prazosin [SEP] A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEAS", "score": 1, "type": null, "tokenized_content": [2, 29041, 5872, 3, 43, 5328, 13672, 4595, 17, 21, 8151, 2251, 1922, 1920, 2311, 1927, 4003, 4574, 31, 5579, 31, 30004, 26493, 31, 6451, 2175, 2009, 2445, 1934, 3]}]}
{"query": {"id": "q_3588", "content": "azidothymidine [SEP] ntagonism between interleukin 3 and erythropoietin in mice with azidothymidine-induced anemia and in bone marrow endothelial cells.", "tokenized_content": [2, 6352, 15072, 28935, 16408, 2053, 3, 20503, 3827, 11110, 1035, 2192, 9198, 23, 1930, 25071, 1922, 2518, 1956, 6352, 15072, 28935, 16408, 2053, 17, 2719, 10679, 1930, 1922, 3622, 6599, 3]}, "items": [{"id": "p_3588", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_3589", "content": "anemia [SEP] leukin 3 and erythropoietin in mice with azidothymidine-induced anemia and in bone marrow endothelial cells.", "tokenized_content": [2, 10679, 3, 5104, 1921, 23, 1930, 25071, 1922, 2518, 1956, 6352, 15072, 28935, 16408, 2053, 17, 2719, 10679, 1930, 1922, 3622, 6599, 5003, 2094, 18, 3]}, "items": [{"id": "p_3589", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_3590", "content": "Azidothymidine [SEP] Azidothymidine (AZT)-induced anemia in mice can be reversed by the administrat", "tokenized_content": [2, 6352, 15072, 28935, 16408, 2053, 3, 6352, 15072, 28935, 16408, 2053, 12, 28301, 13, 17, 2719, 10679, 1922, 2518, 2112, 1998, 9432, 2007, 1920, 10473, 1926, 3]}, "items": [{"id": "p_3590", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_3591", "content": "AZT [SEP] Azidothymidine (AZT)-induced anemia in mice can be reversed by the administration o", "tokenized_content": [2, 28301, 3, 6352, 15072, 28935, 16408, 2053, 12, 28301, 13, 17, 2719, 10679, 1922, 2518, 2112, 1998, 9432, 2007, 1920, 4183, 57, 3]}, "items": [{"id": "p_3591", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_3592", "content": "anemia [SEP] Azidothymidine (AZT)-induced anemia in mice can be reversed by the administration of IGF-IL-3 (fusi", "tokenized_content": [2, 10679, 3, 6352, 15072, 28935, 16408, 2053, 12, 28301, 13, 17, 2719, 10679, 1922, 2518, 2112, 1998, 9432, 2007, 1920, 4183, 1927, 6630, 17, 2614, 17, 23, 12, 10630, 1033, 3]}, "items": [{"id": "p_3592", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_3593", "content": "thymidine [SEP] Azidothymidine (AZT)-induced anemia in mice can be reversed by the administrat", "tokenized_content": [2, 16253, 3, 6352, 15072, 28935, 16408, 2053, 12, 28301, 13, 17, 2719, 10679, 1922, 2518, 2112, 1998, 9432, 2007, 1920, 10473, 1926, 3]}, "items": [{"id": "p_3593", "content": "Thymidine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16253, 3, 3]}]}
{"query": {"id": "q_3594", "content": "Na [SEP] Interactive effects of variations in [Na]o and [Ca]o on rat atrial spontaneous frequency.", "tokenized_content": [2, 4049, 3, 13974, 2564, 1927, 6740, 1922, 37, 4049, 39, 57, 1930, 37, 2332, 39, 57, 1990, 3067, 9224, 6242, 3528, 18, 3]}, "items": [{"id": "p_3594", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3595", "content": "Ca [SEP] Interactive effects of variations in [Na]o and [Ca]o on rat atrial spontaneous frequency.", "tokenized_content": [2, 2332, 3, 13974, 2564, 1927, 6740, 1922, 37, 4049, 39, 57, 1930, 37, 2332, 39, 57, 1990, 3067, 9224, 6242, 3528, 18, 3]}, "items": [{"id": "p_3595", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_3596", "content": "Na [SEP] The effects of varying the extracellular concentrations of Na and Ca ([Na]o and [Ca]o) on both, the spontaneous beating and t", "tokenized_content": [2, 4049, 3, 1920, 2564, 1927, 7155, 1920, 5329, 3295, 1927, 4049, 1930, 2332, 12, 37, 4049, 39, 57, 1930, 37, 2332, 39, 57, 13, 1990, 2321, 16, 1920, 6242, 24711, 3]}, "items": [{"id": "p_3596", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3597", "content": "Ca [SEP] e effects of varying the extracellular concentrations of Na and Ca ([Na]o and [Ca]o) on both, the spontaneous beating and the nega", "tokenized_content": [2, 2332, 3, 47, 2564, 1927, 7155, 1920, 5329, 3295, 1927, 4049, 1930, 2332, 12, 37, 4049, 39, 57, 1930, 37, 2332, 39, 57, 13, 1990, 2321, 16, 1920, 6242, 24711, 3]}, "items": [{"id": "p_3597", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_3598", "content": "verapamil [SEP] the spontaneous beating and the negative chronotropic action of verapamil, were studied in the isolated rat atria. Basal frequency (BF) e", "tokenized_content": [2, 23300, 3, 1920, 6242, 24711, 1930, 1920, 3136, 3589, 8405, 4615, 1927, 23300, 16, 1985, 3942, 1922, 1920, 3937, 3067, 26500, 1019, 18, 5342, 3528, 12, 10171, 13, 47, 3]}, "items": [{"id": "p_3598", "content": "Verapamil [SEP] A calcium channel blocker that is a class IV anti-arrhythmia agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23300, 3, 43, 5016, 4999, 14580, 1988, 1977, 43, 2921, 4370, 2246, 17, 18346, 5899, 18, 3]}]}
{"query": {"id": "q_3599", "content": "bradycardia [SEP] negative chronotropic effects were BF-dependent. Dose-dependent bradycardia induced by verapamil was potentiated by LNa, LCa, and HCa. Inde", "tokenized_content": [2, 26192, 3, 3136, 3589, 8405, 2564, 1985, 10171, 17, 3100, 18, 3253, 17, 3100, 26192, 2719, 2007, 23300, 1982, 20419, 2007, 27248, 16, 23077, 16, 1930, 23595, 18, 2063, 1021, 3]}, "items": [{"id": "p_3599", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_3600", "content": "Sodium [SEP] Sodium status influences chronic amphotericin B nephrotoxicity in rats", "tokenized_content": [2, 5227, 3, 5227, 3642, 8061, 3724, 23210, 44, 27880, 1922, 3615, 3]}, "items": [{"id": "p_3600", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3601", "content": "amphotericin B [SEP] Sodium status influences chronic amphotericin B nephrotoxicity in rats.", "tokenized_content": [2, 23210, 44, 3, 5227, 3642, 8061, 3724, 23210, 44, 27880, 1922, 3615, 18, 3]}, "items": [{"id": "p_3601", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_3602", "content": "nephrotoxicity [SEP] Sodium status influences chronic amphotericin B nephrotoxicity in rats.", "tokenized_content": [2, 27880, 3, 5227, 3642, 8061, 3724, 23210, 44, 27880, 1922, 3615, 18, 3]}, "items": [{"id": "p_3602", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3603", "content": "nephrotoxic [SEP] The nephrotoxic potential of amphotericin B (5 mg/kg per day intraperitoneally ", "tokenized_content": [2, 22994, 10605, 3, 1920, 22994, 10605, 2889, 1927, 23210, 44, 12, 25, 2786, 19, 3621, 2079, 3007, 17245, 3]}, "items": [{"id": "p_3603", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_3604", "content": "amphotericin B [SEP] The nephrotoxic potential of amphotericin B (5 mg/kg per day intraperitoneally for 3 weeks) has been invest", "tokenized_content": [2, 23210, 44, 3, 1920, 22994, 10605, 2889, 1927, 23210, 44, 12, 25, 2786, 19, 3621, 2079, 3007, 17245, 1958, 23, 3625, 13, 2258, 2252, 12476, 3]}, "items": [{"id": "p_3604", "content": "Amphotericin B [SEP] Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.\n  ", "score": 1, "type": null, "tokenized_content": [2, 23210, 44, 3, 23929, 2261, 15216, 7267, 4152, 2007, 22874, 3889, 13650, 2926, 2037, 6072, 1927, 1920, 18176, 11873, 4879, 10423, 3031, 1927, 26803, 19240, 15208, 18, 3]}]}
{"query": {"id": "q_3605", "content": "creatinine [SEP] lt-loaded rats. In salt-depleted rats, amphotericin B decreased creatinine clearance linearly with time, with an 85% reduction by week 3. ", "tokenized_content": [2, 9374, 3, 3457, 17, 7630, 3615, 18, 1922, 7012, 17, 9462, 3615, 16, 23210, 44, 3261, 9374, 7802, 14952, 1956, 2367, 16, 1956, 1925, 5140, 9, 3378, 2007, 2982, 23, 3]}, "items": [{"id": "p_3605", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_3606", "content": "sodium [SEP] for 2 weeks and was decreased by 43% at week 3. All rats in the sodium-depleted group had histopathological evidence of patchy tubular", "tokenized_content": [2, 5227, 3, 1958, 22, 3625, 1930, 1982, 3261, 2007, 3941, 9, 2019, 2982, 23, 18, 2136, 3615, 1922, 1920, 5227, 17, 9462, 2210, 2430, 11777, 3095, 1927, 29795, 11755, 3]}, "items": [{"id": "p_3606", "content": "Sodium [SEP] A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 3, 43, 7210, 1927, 1920, 25178, 2210, 1927, 11570, 18, 2176, 2258, 1920, 11241, 17530, 4049, 16, 11241, 2529, 2513, 16, 1930, 11241, 3388, 3020, 18, 3]}]}
{"query": {"id": "q_3607", "content": "inferior colliculus lesion [SEP] Reversible inferior colliculus lesion in metronidazole-induced encephalopathy: magnetic resonance fin", "tokenized_content": [2, 8756, 2674, 21206, 5709, 3, 10743, 8756, 2674, 21206, 5709, 1922, 26402, 17, 2719, 19393, 30, 5691, 6912, 3502, 3]}, "items": [{"id": "p_3607", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3608", "content": "metronidazole [SEP] Reversible inferior colliculus lesion in metronidazole-induced encephalopathy: magnetic resonance findings on diffusio", "tokenized_content": [2, 26402, 3, 10743, 8756, 2674, 21206, 5709, 1922, 26402, 17, 2719, 19393, 30, 5691, 6912, 3056, 1990, 14344, 3940, 3]}, "items": [{"id": "p_3608", "content": "Metronidazole [SEP] A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFE", "score": 1, "type": null, "tokenized_content": [2, 26402, 3, 43, 8686, 28950, 2251, 1942, 2297, 2150, 13495, 11550, 31, 7715, 11566, 3600, 31, 10477, 10480, 5024, 31, 7217, 13047, 8362, 31, 12554, 4802, 31, 1930, 2171, 21851, 30426, 2122, 1021, 3]}]}
{"query": {"id": "q_3609", "content": "encephalopathy [SEP] Reversible inferior colliculus lesion in metronidazole-induced encephalopathy: magnetic resonance findings on diffusion-weighted and fluid at", "tokenized_content": [2, 19393, 3, 10743, 8756, 2674, 21206, 5709, 1922, 26402, 17, 2719, 19393, 30, 5691, 6912, 3056, 1990, 6601, 17, 7370, 1930, 5466, 2019, 3]}, "items": [{"id": "p_3609", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3610", "content": "inferior colliculus lesions [SEP] OBJECTIVE: This is to present reversible inferior colliculus lesions in metronidazole-induced encephalopathy, to focus on the diffus", "tokenized_content": [2, 8756, 2674, 21206, 4518, 3, 4470, 30, 2052, 1977, 1942, 2481, 10743, 8756, 2674, 21206, 4518, 1922, 26402, 17, 2719, 19393, 16, 1942, 3691, 1990, 1920, 14344, 3]}, "items": [{"id": "p_3610", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3611", "content": "metronidazole [SEP] E: This is to present reversible inferior colliculus lesions in metronidazole-induced encephalopathy, to focus on the diffusion-weighted imag", "tokenized_content": [2, 26402, 3, 47, 30, 2052, 1977, 1942, 2481, 10743, 8756, 2674, 21206, 4518, 1922, 26402, 17, 2719, 19393, 16, 1942, 3691, 1990, 1920, 6601, 17, 7370, 10317, 3]}, "items": [{"id": "p_3611", "content": "Metronidazole [SEP] A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFE", "score": 1, "type": null, "tokenized_content": [2, 26402, 3, 43, 8686, 28950, 2251, 1942, 2297, 2150, 13495, 11550, 31, 7715, 11566, 3600, 31, 10477, 10480, 5024, 31, 7217, 13047, 8362, 31, 12554, 4802, 31, 1930, 2171, 21851, 30426, 2122, 1021, 3]}]}
{"query": {"id": "q_3612", "content": "encephalopathy [SEP] reversible inferior colliculus lesions in metronidazole-induced encephalopathy, to focus on the diffusion-weighted imaging (DWI) and fluid att", "tokenized_content": [2, 19393, 3, 10743, 8756, 2674, 21206, 4518, 1922, 26402, 17, 2719, 19393, 16, 1942, 3691, 1990, 1920, 6601, 17, 7370, 3755, 12, 20305, 13, 1930, 5466, 3099, 3]}, "items": [{"id": "p_3612", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3613", "content": "infection [SEP] l dosage, 45-120 g; duration, 30 days to 2 months) to treat the infection in various organs. Initial brain magnetic resonance imaging (MR", "tokenized_content": [2, 2909, 3, 54, 9998, 16, 3607, 17, 6103, 49, 31, 4392, 16, 2627, 3000, 1942, 22, 3221, 13, 1942, 2297, 1920, 2909, 1922, 3425, 7393, 18, 3754, 3068, 5691, 6912, 3]}, "items": [{"id": "p_3613", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_3614", "content": "callosal lesion [SEP]  follow-up MRIs in 5 patients, but in 1 patient of them, corpus callosal lesion persisted. CONCLUSIONS: Reversible inferior colliculus lesions ", "tokenized_content": [2, 4567, 8136, 5709, 3, 2396, 17, 2353, 5371, 1036, 1922, 25, 2132, 16, 2308, 1922, 21, 2774, 1927, 3581, 16, 13776, 4567, 8136, 5709, 14583, 18, 4355, 30, 10743, 8756, 3]}, "items": [{"id": "p_3614", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3615", "content": "morphine [SEP] Comparison of the respiratory effects of i.v. infusions of morphine and regional analgesia by extradural block.", "tokenized_content": [2, 11553, 3, 3723, 1927, 1920, 5481, 2564, 1927, 51, 18, 64, 18, 17656, 1927, 11553, 1930, 6937, 14695, 2007, 8324, 10015, 7317, 3367, 18, 3]}, "items": [{"id": "p_3615", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_3616", "content": "apnoea [SEP] The incidence of postoperative respiratory apnoea was compared between five patients receiving a continuous i.v. ", "tokenized_content": [2, 2100, 26447, 3, 1920, 4332, 1927, 5924, 5481, 2100, 26447, 1982, 2452, 2192, 3628, 2132, 5962, 43, 4798, 51, 18, 64, 18, 3]}, "items": [{"id": "p_3616", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_3617", "content": "morphine [SEP] d between five patients receiving a continuous i.v. infusion of morphine (mean 73.6 mg) and five patients receiving a continuous extradu", "tokenized_content": [2, 11553, 3, 46, 2192, 3628, 2132, 5962, 43, 4798, 51, 18, 64, 18, 7386, 1927, 11553, 12, 2667, 5356, 18, 26, 2786, 13, 1930, 3628, 2132, 5962, 43, 4798, 8324, 3]}, "items": [{"id": "p_3617", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_3618", "content": "bupivacaine [SEP] ve patients receiving a continuous extradural infusion of 0.25% bupivacaine (mean 192 mg) in the 24-h period following upper abdominal surg", "tokenized_content": [2, 25473, 3, 3428, 2132, 5962, 43, 4798, 8324, 10015, 7317, 7386, 1927, 20, 18, 2637, 9, 25473, 12, 2667, 15249, 2786, 13, 1922, 1920, 2686, 17, 50, 3047, 2894, 5199, 3]}, "items": [{"id": "p_3618", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_3619", "content": "carbon dioxide [SEP] dominal surgery. Monitoring consisted of airflow detection by a carbon dioxide analyser, chest wall movement detected by pneumatic capsules, a", "tokenized_content": [2, 5056, 15422, 3, 2804, 2526, 3782, 18, 5378, 6994, 1927, 22857, 3805, 2007, 43, 5056, 15422, 14708, 1005, 16, 8475, 4821, 5829, 3330, 2007, 6097, 2479, 20206, 16, 43, 3]}, "items": [{"id": "p_3619", "content": "Carbon Dioxide [SEP] A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5056, 15422, 3, 43, 29500, 16, 12685, 5427, 4422, 1988, 2112, 1998, 5333, 2007, 1920, 3362, 1930, 1977, 4680, 1958, 1920, 11695, 4048, 1927, 4793, 1930, 3555, 18, 3]}]}
{"query": {"id": "q_3620", "content": "central apnoea [SEP] ter ambulatory monitor. Both obstructive (P less than 0.05) and central apnoea (P less than 0.05) occurred more frequently in patients who had", "tokenized_content": [2, 4101, 2100, 26447, 3, 6005, 15280, 8434, 18, 2321, 12234, 12, 58, 2941, 2254, 20, 18, 2914, 13, 1930, 4101, 2100, 26447, 12, 58, 2941, 2254, 20, 18, 2914, 13, 3]}, "items": [{"id": "p_3620", "content": "Sleep Apnea, Central [SEP] A condition associated with multiple episodes of sleep apnea which are distinguished from obstructive sleep apnea (SLEEP APNEA, ", "score": 1, "type": null, "tokenized_content": [2, 5006, 17578, 16, 4101, 3, 43, 2625, 2458, 1956, 3137, 9232, 1927, 5006, 17578, 2154, 2032, 12080, 2037, 12234, 5006, 17578, 12, 5006, 17578, 16, 3]}]}
{"query": {"id": "q_3621", "content": "tachyarrhythmias [SEP] o had a morphine infusion. There was also a higher incidence of tachyarrhythmias (P less than 0.05) and ventricular ectopic beats (P less than 0", "tokenized_content": [2, 12762, 9771, 18858, 10245, 15519, 3, 57, 2430, 43, 11553, 7386, 18, 2276, 1982, 2222, 43, 2580, 4332, 1927, 12762, 9771, 18858, 10245, 15519, 12, 58, 2941, 2254, 20, 18, 3]}, "items": [{"id": "p_3621", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_3622", "content": "ventricular ectopic beats [SEP] o a higher incidence of tachyarrhythmias (P less than 0.05) and ventricular ectopic beats (P less than 0.05) in the morphine infusion group.", "tokenized_content": [2, 6493, 11092, 19380, 3, 57, 43, 2580, 4332, 1927, 12762, 9771, 18858, 10245, 15519, 12, 58, 2941, 2254, 20, 18, 2914, 13, 1930, 6493, 11092, 19380, 12, 58, 2941, 2254, 3]}, "items": [{"id": "p_3622", "content": "Ventricular Premature Complexes [SEP] A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS compl", "score": 1, "type": null, "tokenized_content": [2, 6493, 9839, 5048, 3, 43, 2601, 1927, 4435, 18346, 1956, 9839, 15465, 1927, 1920, 4003, 21008, 18, 2176, 1977, 4378, 2007, 1920, 9839, 22355, 6581, 3]}]}
{"query": {"id": "q_3623", "content": "epileptic [SEP] Magnetic resonance volumetry of the cerebellum in epileptic patients after phenytoin overdosages.", "tokenized_content": [2, 16304, 3, 5691, 6912, 3776, 9705, 1927, 1920, 12079, 1922, 16304, 2132, 2256, 3037, 30177, 17612, 5360, 2286, 18, 3]}, "items": [{"id": "p_3623", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_3624", "content": "phenytoin [SEP] sonance volumetry of the cerebellum in epileptic patients after phenytoin overdosages.", "tokenized_content": [2, 3037, 30177, 3, 9337, 2152, 3776, 9705, 1927, 1920, 12079, 1922, 16304, 2132, 2256, 3037, 30177, 17612, 5360, 2286, 18, 3]}, "items": [{"id": "p_3624", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_3625", "content": "overdosages [SEP] lumetry of the cerebellum in epileptic patients after phenytoin overdosages.", "tokenized_content": [2, 17612, 5360, 2286, 3, 5491, 5414, 1927, 1920, 12079, 1922, 16304, 2132, 2256, 3037, 30177, 17612, 5360, 2286, 18, 3]}, "items": [{"id": "p_3625", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_3626", "content": "phenytoin [SEP] The aim of this study was to evaluate the relationship between phenytoin medication and cerebellar atrophy in patients who had experienc", "tokenized_content": [2, 3037, 30177, 3, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 4323, 1920, 3303, 2192, 3037, 30177, 6093, 1930, 11459, 10260, 1922, 2132, 2746, 2430, 3551, 2135, 3]}, "items": [{"id": "p_3626", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_3627", "content": "cerebellar atrophy [SEP] s to evaluate the relationship between phenytoin medication and cerebellar atrophy in patients who had experienced clinical intoxication. Five fem", "tokenized_content": [2, 11459, 10260, 3, 61, 1942, 4323, 1920, 3303, 2192, 3037, 30177, 6093, 1930, 11459, 10260, 1922, 2132, 2746, 2430, 6090, 2535, 20965, 18, 3628, 3210, 3]}, "items": [{"id": "p_3627", "content": "Cerebellar Diseases [SEP] Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysm", "score": 1, "type": null, "tokenized_content": [2, 11459, 3902, 3, 3902, 1988, 4081, 1920, 3170, 2014, 2347, 1927, 1920, 12079, 18, 27529, 10952, 1927, 11459, 5273, 3951, 26906, 3]}]}
{"query": {"id": "q_3628", "content": "seizure [SEP] g linear regression we found that no correlation exists between seizure duration, elevation of phenytoin serum levels and cerebellar vo", "tokenized_content": [2, 11015, 3, 49, 4258, 4165, 2038, 2435, 1988, 2239, 3670, 8655, 2192, 11015, 4392, 16, 8644, 1927, 3037, 30177, 3256, 2428, 1930, 11459, 9805, 3]}, "items": [{"id": "p_3628", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3629", "content": "overdosage [SEP] d a correlation of these parameters. We conclude that phenytoin overdosage does not necessarily result in cerebellar atrophy and it is unl", "tokenized_content": [2, 17612, 5360, 2106, 3, 46, 43, 3670, 1927, 2144, 3673, 18, 2038, 7676, 1988, 3037, 30177, 17612, 5360, 2106, 3731, 2084, 9409, 3211, 1922, 11459, 10260, 1930, 2176, 1977, 4774, 3]}, "items": [{"id": "p_3629", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_3630", "content": "cerebellar disorders [SEP] e cerebellum provide valuable insights into the pathogenesis of cerebellar disorders.", "tokenized_content": [2, 11459, 4414, 3, 47, 12079, 3394, 8619, 8486, 2460, 1920, 6559, 1927, 11459, 4414, 18, 3]}, "items": [{"id": "p_3630", "content": "Cerebellar Diseases [SEP] Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysm", "score": 1, "type": null, "tokenized_content": [2, 11459, 3902, 3, 3902, 1988, 4081, 1920, 3170, 2014, 2347, 1927, 1920, 12079, 18, 27529, 10952, 1927, 11459, 5273, 3951, 26906, 3]}]}
{"query": {"id": "q_3631", "content": "myocardial damage [SEP] Evaluation of cardiac troponin I and T levels as markers of myocardial damage in doxorubicin-induced cardiomyopathy rats, and their relations", "tokenized_content": [2, 6497, 4293, 3, 4391, 1927, 4435, 18714, 51, 1930, 62, 2428, 1966, 4432, 1927, 6497, 4293, 1922, 12377, 17, 2719, 14141, 3615, 16, 1930, 2310, 3229, 3]}, "items": [{"id": "p_3631", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3632", "content": "doxorubicin [SEP] diac troponin I and T levels as markers of myocardial damage in doxorubicin-induced cardiomyopathy rats, and their relationship with echoca", "tokenized_content": [2, 12377, 3, 25141, 1030, 18714, 51, 1930, 62, 2428, 1966, 4432, 1927, 6497, 4293, 1922, 12377, 17, 2719, 14141, 3615, 16, 1930, 2310, 3303, 1956, 10934, 3375, 3]}, "items": [{"id": "p_3632", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3633", "content": "cardiomyopathy [SEP] T levels as markers of myocardial damage in doxorubicin-induced cardiomyopathy rats, and their relationship with echocardiographic and histolo", "tokenized_content": [2, 14141, 3, 62, 2428, 1966, 4432, 1927, 6497, 4293, 1922, 12377, 17, 2719, 14141, 3615, 16, 1930, 2310, 3303, 1956, 18700, 1930, 2968, 26356, 3]}, "items": [{"id": "p_3633", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3634", "content": "myocardial cell injury [SEP]  have been shown to be highly sensitive and specific markers of myocardial cell injury. We investigated the diagnostic value of cTnI and cTnT for the ", "tokenized_content": [2, 6497, 2024, 4047, 3, 2162, 2252, 2522, 1942, 1998, 3626, 4532, 1930, 2487, 4432, 1927, 6497, 2024, 4047, 18, 2038, 3845, 1920, 4785, 3113, 1927, 27941, 1930, 3369, 4905, 1958, 3]}, "items": [{"id": "p_3634", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3635", "content": "myocardial damage [SEP] ated the diagnostic value of cTnI and cTnT for the diagnosis of myocardial damage in a rat model of doxorubicin (DOX)-induced cardiomyopathy, and", "tokenized_content": [2, 6497, 4293, 3, 30280, 1007, 1920, 4785, 3113, 1927, 27941, 1930, 3369, 4905, 1958, 1920, 3574, 1927, 6497, 4293, 1922, 43, 3067, 2322, 1927, 12377, 12, 7169, 13, 17, 2719, 3]}, "items": [{"id": "p_3635", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3636", "content": "doxorubicin [SEP] d cTnT for the diagnosis of myocardial damage in a rat model of doxorubicin (DOX)-induced cardiomyopathy, and we examined the relationship ", "tokenized_content": [2, 12377, 3, 46, 3369, 4905, 1958, 1920, 3574, 1927, 6497, 4293, 1922, 43, 3067, 2322, 1927, 12377, 12, 7169, 13, 17, 2719, 14141, 16, 1930, 2038, 3572, 1920, 3303, 3]}, "items": [{"id": "p_3636", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3637", "content": "DOX [SEP] e diagnosis of myocardial damage in a rat model of doxorubicin (DOX)-induced cardiomyopathy, and we examined the relationship betwe", "tokenized_content": [2, 7169, 3, 47, 3574, 1927, 6497, 4293, 1922, 43, 3067, 2322, 1927, 12377, 12, 7169, 13, 17, 2719, 14141, 16, 1930, 2038, 3572, 1920, 3303, 2143, 2172, 3]}, "items": [{"id": "p_3637", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3638", "content": "cardiomyopathy [SEP] f myocardial damage in a rat model of doxorubicin (DOX)-induced cardiomyopathy, and we examined the relationship between serial cTnI and cTnT ", "tokenized_content": [2, 14141, 3, 48, 6497, 4293, 1922, 43, 3067, 2322, 1927, 12377, 12, 7169, 13, 17, 2719, 14141, 16, 1930, 2038, 3572, 1920, 3303, 2192, 9285, 27941, 1930, 3369, 4905, 3]}, "items": [{"id": "p_3638", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_3639", "content": "cardiac disorders [SEP] lationship between serial cTnI and cTnT with the development of cardiac disorders monitored by echocardiography and histological examinations in ", "tokenized_content": [2, 4435, 4414, 3, 4144, 2443, 3050, 2192, 9285, 27941, 1930, 3369, 4905, 1956, 1920, 2740, 1927, 4435, 4414, 7027, 2007, 12814, 1930, 6791, 10643, 1922, 3]}, "items": [{"id": "p_3639", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_3640", "content": "toxicity [SEP] . RESULTS: Eighteen of the DOX rats died prematurely of general toxicity during the 9-week period. End-diastolic (ED) and end-systolic (", "tokenized_content": [2, 5532, 3, 18, 2274, 30, 20461, 1927, 1920, 7169, 3615, 8545, 28283, 1927, 3335, 5532, 2409, 1920, 29, 17, 2982, 3047, 18, 2482, 17, 9395, 12, 3347, 13, 1930, 2482, 3]}, "items": [{"id": "p_3640", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3641", "content": "fibrosis [SEP] led significant slight degrees of perivascular and interstitial fibrosis. In 7 of the 18 rats, degeneration and myocyte vacuolisation we", "tokenized_content": [2, 6769, 3, 4866, 2228, 4964, 6429, 1927, 19946, 1930, 11584, 6769, 18, 1922, 27, 1927, 1920, 2654, 3615, 16, 9174, 1930, 23082, 26684, 6284, 2038, 3]}, "items": [{"id": "p_3641", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_3642", "content": "ischemic injury [SEP] ers/BW and histological findings. CONCLUSIONS: Among markers of ischemic injury after DOX in rats, cTnT showed the greatest ability to detect m", "tokenized_content": [2, 7427, 4047, 3, 22877, 19, 11534, 1930, 6791, 3056, 18, 4355, 30, 2706, 4432, 1927, 7427, 4047, 2256, 7169, 1922, 3615, 16, 3369, 4905, 2594, 1920, 9449, 3682, 1942, 4277, 3]}, "items": [{"id": "p_3642", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_3643", "content": "cardiotoxicity [SEP] be a useful marker for the prediction of experimentally induced cardiotoxicity and possibly for cardioprotective experiments.", "tokenized_content": [2, 30490, 3, 1998, 43, 4707, 4966, 1958, 1920, 5882, 1927, 9568, 2719, 30490, 1930, 6553, 1958, 28063, 3144, 18, 3]}, "items": [{"id": "p_3643", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3644", "content": "pain [SEP] Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ tr", "tokenized_content": [2, 3594, 3, 19555, 17, 4106, 2719, 3594, 4741, 12, 12998, 1036, 13, 30, 43, 4010, 27606, 9388, 2256, 3090, 2025, 3]}, "items": [{"id": "p_3644", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3645", "content": "pain [SEP] Bone pain after transplantation is a frequent complication that can be ca", "tokenized_content": [2, 3594, 3, 3622, 3594, 2256, 6530, 1977, 43, 6439, 9388, 1988, 2112, 1998, 2332, 3]}, "items": [{"id": "p_3645", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3646", "content": "bone marrow [SEP] take of the foot bones. Magnetic resonance imaging demonstrated bone marrow oedema in the painful bones. Pain was not explained by other di", "tokenized_content": [2, 3622, 6599, 3, 6132, 1927, 1920, 8135, 14153, 18, 5691, 6912, 3755, 3161, 3622, 6599, 24110, 1922, 1920, 15806, 14153, 18, 3594, 1982, 2084, 6094, 2007, 2303, 2137, 3]}, "items": [{"id": "p_3646", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_3647", "content": "oedema [SEP] foot bones. Magnetic resonance imaging demonstrated bone marrow oedema in the painful bones. Pain was not explained by other diseases ", "tokenized_content": [2, 24110, 3, 8135, 14153, 18, 5691, 6912, 3755, 3161, 3622, 6599, 24110, 1922, 1920, 15806, 14153, 18, 3594, 1982, 2084, 6094, 2007, 2303, 3902, 3]}, "items": [{"id": "p_3647", "content": "Edema [SEP] Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.\n", "score": 1, "type": null, "tokenized_content": [2, 10144, 3, 4552, 5466, 4858, 1922, 3878, 2014, 3362, 19699, 18, 2501, 2919, 1927, 10144, 2032, 2481, 2441, 1920, 4407, 1922, 8634, 2960, 18, 3]}]}
{"query": {"id": "q_3648", "content": "Pain [SEP] e imaging demonstrated bone marrow oedema in the painful bones. Pain was not explained by other diseases causing foot pain, like ref", "tokenized_content": [2, 3594, 3, 47, 3755, 3161, 3622, 6599, 24110, 1922, 1920, 15806, 14153, 18, 3594, 1982, 2084, 6094, 2007, 2303, 3902, 7538, 8135, 3594, 16, 3189, 4082, 3]}, "items": [{"id": "p_3648", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_3649", "content": "reflex sympathetic dystrophy [SEP] ain was not explained by other diseases causing foot pain, like reflex sympathetic dystrophy, polyneuropathy, Morton's neuralgia, gout, osteoporosis, avascu", "tokenized_content": [2, 11573, 11739, 19321, 3, 9798, 1022, 1982, 2084, 6094, 2007, 2303, 3902, 7538, 8135, 3594, 16, 3189, 11573, 11739, 19321, 16, 15176, 3708, 13117, 16, 22787, 1916, 11, 61, 5181, 3]}, "items": [{"id": "p_3649", "content": "Reflex Sympathetic Dystrophy [SEP] A syndrome characterized by severe burning pain in an extremity accompanied by sudomotor, vasomotor, and trophic changes in bone", "score": 1, "type": null, "tokenized_content": [2, 11573, 11739, 19321, 3, 43, 4741, 4378, 2007, 4010, 22873, 3594, 1922, 1925, 14884, 7936, 2007, 9601, 10335, 16, 22866, 12492, 2684, 16, 1930, 19030, 2840, 1922, 3622, 3]}]}
{"query": {"id": "q_3650", "content": "polyneuropathy [SEP]  diseases causing foot pain, like reflex sympathetic dystrophy, polyneuropathy, Morton's neuralgia, gout, osteoporosis, avascular necrosis, in", "tokenized_content": [2, 15176, 3708, 13117, 3, 3902, 7538, 8135, 3594, 16, 3189, 11573, 11739, 19321, 16, 15176, 3708, 13117, 16, 22787, 1916, 11, 61, 5181, 11966, 16, 22952, 16, 12340, 16, 2781, 3]}, "items": [{"id": "p_3650", "content": "Polyneuropathies [SEP] Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral dist", "score": 1, "type": null, "tokenized_content": [2, 15176, 3708, 7262, 2062, 3, 3902, 1927, 3137, 5009, 12014, 7159, 18, 15176, 3708, 7262, 2062, 5394, 2032, 4378, 2007, 20410, 16, 7787, 3653, 3]}]}
{"query": {"id": "q_3651", "content": "Morton's neuralgia [SEP] g foot pain, like reflex sympathetic dystrophy, polyneuropathy, Morton's neuralgia, gout, osteoporosis, avascular necrosis, intermittent claudicat", "tokenized_content": [2, 22787, 1916, 11, 61, 5181, 11966, 3, 49, 8135, 3594, 16, 3189, 11573, 11739, 19321, 16, 15176, 3708, 13117, 16, 22787, 1916, 11, 61, 5181, 11966, 16, 22952, 16, 12340, 3]}, "items": [{"id": "p_3651", "content": "Neuralgia [SEP] Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5181, 11966, 3, 10702, 2014, 3546, 1941, 3594, 1988, 5110, 4231, 1920, 4914, 2014, 3282, 1927, 43, 5009, 2014, 13598, 5507, 18, 3]}]}
{"query": {"id": "q_3652", "content": "gout [SEP] flex sympathetic dystrophy, polyneuropathy, Morton's neuralgia, gout, osteoporosis, avascular necrosis, intermittent claudication, o", "tokenized_content": [2, 22952, 3, 5795, 11739, 19321, 16, 15176, 3708, 13117, 16, 22787, 1916, 11, 61, 5181, 11966, 16, 22952, 16, 12340, 16, 2781, 3289, 7476, 16, 13252, 27094, 2959, 16, 57, 3]}, "items": [{"id": "p_3652", "content": "Gout [SEP] Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and ar", "score": 1, "type": null, "tokenized_content": [2, 22952, 3, 16321, 4487, 4770, 4378, 2007, 7457, 3939, 8884, 16, 4194, 15861, 3847, 1930, 7860, 1927, 5227, 3674, 2010, 1922, 1930, 2245, 3]}]}
{"query": {"id": "q_3653", "content": "osteoporosis [SEP] ympathetic dystrophy, polyneuropathy, Morton's neuralgia, gout, osteoporosis, avascular necrosis, intermittent claudication, orthopaedic foo", "tokenized_content": [2, 12340, 3, 23143, 10558, 19321, 16, 15176, 3708, 13117, 16, 22787, 1916, 11, 61, 5181, 11966, 16, 22952, 16, 12340, 16, 2781, 3289, 7476, 16, 13252, 27094, 2959, 16, 22333, 3]}, "items": [{"id": "p_3653", "content": "Osteoporosis [SEP] Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two m", "score": 1, "type": null, "tokenized_content": [2, 12340, 3, 3378, 1927, 3622, 3411, 2979, 10076, 1922, 1920, 5128, 1927, 3622, 16, 4523, 1942, 9018, 18, 3065, 12340, 2112, 1998, 1927, 2288, 55, 3]}]}
{"query": {"id": "q_3654", "content": "avascular necrosis [SEP] trophy, polyneuropathy, Morton's neuralgia, gout, osteoporosis, avascular necrosis, intermittent claudication, orthopaedic foot deformities, stres", "tokenized_content": [2, 2781, 3289, 7476, 3, 15112, 1012, 16, 15176, 3708, 13117, 16, 22787, 1916, 11, 61, 5181, 11966, 16, 22952, 16, 12340, 16, 2781, 3289, 7476, 16, 13252, 27094, 2959, 16, 3]}, "items": [{"id": "p_3654", "content": "Osteonecrosis [SEP] Death of a bone or part of a bone, either atraumatic or posttraumatic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4416, 29525, 4870, 3, 3539, 1927, 43, 3622, 2014, 3131, 1927, 43, 3622, 16, 3108, 20319, 23813, 2002, 2014, 20999, 18, 3]}]}
{"query": {"id": "q_3655", "content": "intermittent claudication [SEP] hy, Morton's neuralgia, gout, osteoporosis, avascular necrosis, intermittent claudication, orthopaedic foot deformities, stress fractures, and hyperparat", "tokenized_content": [2, 13252, 27094, 2959, 3, 4527, 16, 22787, 1916, 11, 61, 5181, 11966, 16, 22952, 16, 12340, 16, 2781, 3289, 7476, 16, 13252, 27094, 2959, 16, 22333, 8135, 26224, 16, 3071, 3]}, "items": [{"id": "p_3655", "content": "Intermittent Claudication [SEP] A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and wea", "score": 1, "type": null, "tokenized_content": [2, 13252, 27094, 2959, 3, 43, 3226, 2796, 4378, 2007, 3594, 1930, 12175, 1922, 7345, 3760, 2210, 2458, 1956, 4975, 16, 2427, 1966, 6703, 3594, 1930, 2038, 1019, 3]}]}
{"query": {"id": "q_3656", "content": "foot deformities [SEP] sis, avascular necrosis, intermittent claudication, orthopaedic foot deformities, stress fractures, and hyperparathyroidism. The reduction of cy", "tokenized_content": [2, 8135, 26224, 3, 19149, 16, 2781, 3289, 7476, 16, 13252, 27094, 2959, 16, 22333, 8135, 26224, 16, 3071, 9018, 16, 1930, 30247, 18, 1920, 3378, 1927, 6002, 3]}, "items": [{"id": "p_3656", "content": "Foot Deformities [SEP] Alterations or deviations from normal shape or size which result in a disfigurement of the foot.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8135, 26224, 3, 5996, 2014, 9804, 2037, 2791, 5989, 2014, 3081, 2154, 3211, 1922, 43, 2054, 9344, 29228, 1927, 1920, 8135, 18, 3]}]}
{"query": {"id": "q_3657", "content": "stress fractures [SEP] rosis, intermittent claudication, orthopaedic foot deformities, stress fractures, and hyperparathyroidism. The reduction of cyclosporine- or tac", "tokenized_content": [2, 3071, 9018, 3, 4742, 1937, 16, 13252, 27094, 2959, 16, 22333, 8135, 26224, 16, 3071, 9018, 16, 1930, 30247, 18, 1920, 3378, 1927, 21002, 17, 2014, 9214, 3]}, "items": [{"id": "p_3657", "content": "Fractures, Stress [SEP] Fractures due to the strain caused by repetitive exercise. They are thought to arise from a combination of MUSCLE FATIGUE and bo", "score": 1, "type": null, "tokenized_content": [2, 9018, 16, 3071, 3, 9018, 2810, 1942, 1920, 3943, 4189, 2007, 12089, 4975, 18, 2611, 2032, 6212, 1942, 10149, 2037, 43, 3921, 1927, 3760, 8656, 1930, 4078, 3]}]}
{"query": {"id": "q_3658", "content": "hyperparathyroidism [SEP] audication, orthopaedic foot deformities, stress fractures, and hyperparathyroidism. The reduction of cyclosporine- or tacrolimus trough levels and", "tokenized_content": [2, 30247, 3, 18219, 11281, 2001, 16, 22333, 8135, 26224, 16, 3071, 9018, 16, 1930, 30247, 18, 1920, 3378, 1927, 21002, 17, 2014, 21801, 19737, 2428, 1930, 3]}, "items": [{"id": "p_3658", "content": "Hyperparathyroidism [SEP] A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It i", "score": 1, "type": null, "tokenized_content": [2, 30247, 3, 43, 2625, 1927, 20756, 4664, 6647, 1927, 17152, 6365, 12, 2014, 13330, 13, 14074, 3387, 1988, 2760, 2877, 5016, 18, 2176, 51, 3]}]}
{"query": {"id": "q_3659", "content": "cyclosporine [SEP] es, stress fractures, and hyperparathyroidism. The reduction of cyclosporine- or tacrolimus trough levels and the administration of calcium ", "tokenized_content": [2, 21002, 3, 2376, 16, 3071, 9018, 16, 1930, 30247, 18, 1920, 3378, 1927, 21002, 17, 2014, 21801, 19737, 2428, 1930, 1920, 4183, 1927, 5016, 3]}, "items": [{"id": "p_3659", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_3660", "content": "tacrolimus [SEP] res, and hyperparathyroidism. The reduction of cyclosporine- or tacrolimus trough levels and the administration of calcium channel blocker", "tokenized_content": [2, 21801, 3, 1995, 16, 1930, 30247, 18, 1920, 3378, 1927, 21002, 17, 2014, 21801, 19737, 2428, 1930, 1920, 4183, 1927, 5016, 4999, 14580, 3]}, "items": [{"id": "p_3660", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_3661", "content": "calcium [SEP] osporine- or tacrolimus trough levels and the administration of calcium channel blockers led to relief of pain. The Calcineurin-inhibit", "tokenized_content": [2, 5016, 3, 3125, 2074, 2053, 17, 2014, 21801, 19737, 2428, 1930, 1920, 4183, 1927, 5016, 4999, 13628, 4866, 1942, 13104, 1927, 3594, 18, 1920, 19555, 17, 2875, 3]}, "items": [{"id": "p_3661", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_3662", "content": "propofol [SEP] The haemodynamic effects of propofol in combination with ephedrine in elderly patients (ASA groups 3", "tokenized_content": [2, 16615, 3, 1920, 29730, 2564, 1927, 16615, 1922, 3921, 1956, 12717, 1919, 5773, 1922, 7354, 2132, 12, 15634, 2671, 23, 3]}, "items": [{"id": "p_3662", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_3663", "content": "ephedrine [SEP] The haemodynamic effects of propofol in combination with ephedrine in elderly patients (ASA groups 3 and 4).", "tokenized_content": [2, 12717, 1919, 5773, 3, 1920, 29730, 2564, 1927, 16615, 1922, 3921, 1956, 12717, 1919, 5773, 1922, 7354, 2132, 12, 15634, 2671, 23, 1930, 24, 13, 18, 3]}, "items": [{"id": "p_3663", "content": "Ephedrine [SEP] A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may als", "score": 1, "type": null, "tokenized_content": [2, 12717, 1919, 5773, 3, 43, 3037, 5188, 3812, 2435, 1922, 12717, 1919, 5524, 3132, 6102, 18, 11520, 2128, 13521, 5773, 1977, 1925, 15348, 18, 2176, 1977, 1925, 4595, 17, 1930, 4666, 17, 13672, 7829, 1988, 2278, 10534, 3]}]}
{"query": {"id": "q_3664", "content": "propofol [SEP] The marked vasodilator and negative inotropic effects of propofol are disadvantages in frail elderly patients. We investigated th", "tokenized_content": [2, 16615, 3, 1920, 4961, 28194, 1930, 3136, 28853, 2564, 1927, 16615, 2032, 18275, 1922, 14045, 7354, 2132, 18, 2038, 3845, 1913, 3]}, "items": [{"id": "p_3664", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_3665", "content": "ephedrine [SEP] vestigated the safety and efficacy of adding different doses of ephedrine to propofol in order to obtund the hypotensive response. The ha", "tokenized_content": [2, 12717, 1919, 5773, 3, 5634, 2677, 1981, 1920, 5407, 1930, 4348, 1927, 8013, 2413, 5312, 1927, 12717, 1919, 5773, 1942, 16615, 1922, 3238, 1942, 25683, 2652, 1920, 12201, 3766, 2644, 3]}, "items": [{"id": "p_3665", "content": "Ephedrine [SEP] A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may als", "score": 1, "type": null, "tokenized_content": [2, 12717, 1919, 5773, 3, 43, 3037, 5188, 3812, 2435, 1922, 12717, 1919, 5524, 3132, 6102, 18, 11520, 2128, 13521, 5773, 1977, 1925, 15348, 18, 2176, 1977, 1925, 4595, 17, 1930, 4666, 17, 13672, 7829, 1988, 2278, 10534, 3]}]}
{"query": {"id": "q_3666", "content": "hypotensive [SEP] different doses of ephedrine to propofol in order to obtund the hypotensive response. The haemodynamic effects of adding 15, 20 or 25 mg of", "tokenized_content": [2, 12201, 3766, 3, 2413, 5312, 1927, 12717, 1919, 5773, 1942, 16615, 1922, 3238, 1942, 25683, 2652, 1920, 12201, 3766, 2644, 18, 1920, 29730, 2564, 1927, 8013, 2461, 16, 2036, 2014, 3]}, "items": [{"id": "p_3666", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_3667", "content": "tachycardia [SEP] se to propofol at all doses used in this study. However, marked tachycardia associated with the use of ephedrine in combination with propof", "tokenized_content": [2, 17397, 3, 2058, 1942, 16615, 2019, 2136, 5312, 2251, 1922, 2052, 2161, 18, 2406, 16, 4961, 17397, 2458, 1956, 1920, 2485, 1927, 12717, 1919, 5773, 1922, 3921, 1956, 5062, 4199, 3]}, "items": [{"id": "p_3667", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_3668", "content": "myocardial ischemia [SEP] dividual patients. Due to the risk of this tachycardia inducing myocardial ischemia, we would not recommend the use in elderly patients of any of t", "tokenized_content": [2, 6497, 7716, 3, 5292, 2224, 2132, 18, 2810, 1942, 1920, 2565, 1927, 2052, 17397, 7834, 6497, 7716, 16, 2038, 2962, 2084, 5732, 1920, 2485, 1922, 7354, 2132, 1927, 2967, 1927, 3]}, "items": [{"id": "p_3668", "content": "Myocardial Ischemia [SEP] A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may", "score": 1, "type": null, "tokenized_content": [2, 6497, 7716, 3, 43, 4770, 1927, 4435, 2347, 4189, 2007, 9406, 2877, 3426, 1942, 1920, 3760, 2960, 1927, 1920, 4003, 18, 1920, 3261, 2877, 3426, 2278, 3]}]}
{"query": {"id": "q_3669", "content": "Neurotoxicity [SEP] Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases re", "tokenized_content": [2, 18034, 3, 18034, 1927, 24778, 1981, 8275, 11072, 8419, 1036, 30, 2535, 2333, 1927, 2919, 1964, 3]}, "items": [{"id": "p_3669", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3670", "content": "halogenated hydroxyquinolines [SEP] Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan.", "tokenized_content": [2, 24778, 1981, 8275, 11072, 8419, 1036, 3, 18034, 1927, 24778, 1981, 8275, 11072, 8419, 1036, 30, 2535, 2333, 1927, 2919, 2568, 7008, 5834, 18, 3]}, "items": [{"id": "p_3670", "content": "Hydroxyquinolines [SEP] The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti", "score": 1, "type": null, "tokenized_content": [2, 8275, 11072, 8419, 1036, 3, 1920, 28, 17, 8275, 8383, 2875, 3425, 5038, 1930, 2310, 24778, 1981, 8383, 16, 4170, 20919, 16, 2032, 2251, 1966, 12259, 2246, 3]}]}
{"query": {"id": "q_3671", "content": "neurotoxic [SEP] An analysis is presented of 220 cases of possible neurotoxic reactions to halogenated hydroxyquinolines reported from outsid", "tokenized_content": [2, 20919, 3, 1925, 2333, 1977, 3549, 1927, 12391, 2919, 1927, 3216, 20919, 5298, 1942, 24778, 1981, 8275, 11072, 8419, 1036, 2568, 2037, 6459, 1960, 3]}, "items": [{"id": "p_3671", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3672", "content": "halogenated hydroxyquinolines [SEP] s is presented of 220 cases of possible neurotoxic reactions to halogenated hydroxyquinolines reported from outside Japan. In 80 cases insufficient informati", "tokenized_content": [2, 24778, 1981, 8275, 11072, 8419, 1036, 3, 61, 1977, 3549, 1927, 12391, 2919, 1927, 3216, 20919, 5298, 1942, 24778, 1981, 8275, 11072, 8419, 1036, 2568, 2037, 7008, 5834, 18, 1922, 3]}, "items": [{"id": "p_3672", "content": "Hydroxyquinolines [SEP] The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti", "score": 1, "type": null, "tokenized_content": [2, 8275, 11072, 8419, 1036, 3, 1920, 28, 17, 8275, 8383, 2875, 3425, 5038, 1930, 2310, 24778, 1981, 8383, 16, 4170, 20919, 16, 2032, 2251, 1966, 12259, 2246, 3]}]}
{"query": {"id": "q_3673", "content": "clioquinol [SEP] quate comment and in 29 a relationship to the administration of clioquinol could be excluded. Of the remainder, a relationship to clioquin", "tokenized_content": [2, 2111, 3940, 11072, 1945, 3, 2571, 2010, 17209, 1930, 1922, 3230, 43, 3303, 1942, 1920, 4183, 1927, 2111, 3940, 11072, 1945, 2578, 1998, 5450, 18, 1927, 1920, 15834, 16, 43, 3]}, "items": [{"id": "p_3673", "content": "Clioquinol [SEP] A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal", "score": 1, "type": null, "tokenized_content": [2, 2111, 3940, 11072, 1945, 3, 43, 5063, 20919, 28, 17, 8275, 11072, 8419, 10533, 2815, 2251, 1966, 43, 12259, 2246, 17, 20905, 16, 6139, 2246, 4171, 3821, 1030, 16, 1930, 10120, 3]}]}
{"query": {"id": "q_3674", "content": "neurological disturbance [SEP] n 42 and possible in 69 cases. In six of the probable cases the neurological disturbance consisted of an acute reversible encephalopathy usually related", "tokenized_content": [2, 7605, 12732, 3, 56, 3858, 1930, 3216, 1922, 5349, 2919, 18, 1922, 3798, 1927, 1920, 12584, 2919, 1920, 7605, 12732, 6994, 1927, 1925, 3939, 10743, 19393, 5394, 2712, 3]}, "items": [{"id": "p_3674", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_3675", "content": "encephalopathy [SEP] s the neurological disturbance consisted of an acute reversible encephalopathy usually related to the ingestion of a high dose of clioquinol o", "tokenized_content": [2, 19393, 3, 61, 1920, 7605, 12732, 6994, 1927, 1925, 3939, 10743, 19393, 5394, 2712, 1942, 1920, 14195, 1927, 43, 2149, 3253, 1927, 2111, 3940, 11072, 1945, 57, 3]}, "items": [{"id": "p_3675", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_3676", "content": "optic atrophy [SEP] ommon manifestation, observed in 15 further cases, was isolated optic atrophy. This was most frequently found in children, many of whom had r", "tokenized_content": [2, 10109, 10260, 3, 7254, 3947, 15570, 16, 2528, 1922, 2461, 2520, 2919, 16, 1982, 3937, 10109, 10260, 18, 2052, 1982, 2501, 5467, 2435, 1922, 3069, 16, 3086, 1927, 8566, 2430, 3]}, "items": [{"id": "p_3676", "content": "Optic Atrophy [SEP] Atrophy of the optic disk which may be congenital or acquired. This condition indicates a deficiency in the number of nerve fibe", "score": 1, "type": null, "tokenized_content": [2, 10109, 10260, 3, 10260, 1927, 1920, 10109, 15598, 2154, 2278, 1998, 9901, 2014, 5815, 18, 2052, 2625, 4538, 43, 6179, 1922, 1920, 2529, 1927, 5507, 3042, 1021, 3]}]}
{"query": {"id": "q_3677", "content": "acrodermatitis enteropathica [SEP] children, many of whom had received clioquinol as treatment for acrodermatitis enteropathica. In the remaining cases, a combination of myelopathy, visual di", "tokenized_content": [2, 10428, 20532, 11648, 5553, 10982, 1019, 3, 3069, 16, 3086, 1927, 8566, 2430, 4004, 2111, 3940, 11072, 1945, 1966, 2311, 1958, 10428, 20532, 11648, 5553, 10982, 1019, 18, 1922, 1920, 3]}, "items": [{"id": "p_3677", "content": "Acrodermatitis enteropathica [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10428, 20532, 11648, 5553, 10982, 1019, 3, 3]}]}
{"query": {"id": "q_3678", "content": "myelopathy [SEP] matitis enteropathica. In the remaining cases, a combination of myelopathy, visual disturbance, and peripheral neuropathy was the most com", "tokenized_content": [2, 5707, 6522, 3, 2888, 3678, 5553, 10982, 1019, 18, 1922, 1920, 5719, 2919, 16, 43, 3921, 1927, 5707, 6522, 16, 3737, 12732, 16, 1930, 5009, 13177, 1982, 1920, 2501, 2008, 3]}, "items": [{"id": "p_3678", "content": "Spinal Cord Diseases [SEP] Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimening", "score": 1, "type": null, "tokenized_content": [2, 6071, 6670, 3902, 3, 11896, 2961, 2154, 5961, 6071, 6670, 4293, 2014, 5273, 16, 2710, 4414, 5884, 1920, 10286, 1918, 1930, 2953, 19047, 1941, 3]}]}
{"query": {"id": "q_3679", "content": "visual disturbance [SEP] ropathica. In the remaining cases, a combination of myelopathy, visual disturbance, and peripheral neuropathy was the most common manifestation. I", "tokenized_content": [2, 3737, 12732, 3, 17890, 21494, 1019, 18, 1922, 1920, 5719, 2919, 16, 43, 3921, 1927, 5707, 6522, 16, 3737, 12732, 16, 1930, 5009, 13177, 1982, 1920, 2501, 3059, 15570, 18, 3]}, "items": [{"id": "p_3679", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_3680", "content": "peripheral neuropathy [SEP] ing cases, a combination of myelopathy, visual disturbance, and peripheral neuropathy was the most common manifestation. Isolated myelopathy or perip", "tokenized_content": [2, 5009, 13177, 3, 30393, 2919, 16, 43, 3921, 1927, 5707, 6522, 16, 3737, 12732, 16, 1930, 5009, 13177, 1982, 1920, 2501, 3059, 15570, 18, 3937, 5707, 6522, 2014, 4610, 3]}, "items": [{"id": "p_3680", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_3681", "content": "optic neuropathy [SEP]  display more side effects. The full syndrome of subacute myelo-optic neuropathy was more frequent in women, but they tended to have taken great", "tokenized_content": [2, 10109, 13177, 3, 4434, 2253, 4159, 2564, 18, 1920, 4125, 4741, 1927, 25440, 5707, 1037, 17, 10109, 13177, 1982, 2253, 6439, 1922, 3089, 16, 2308, 2611, 10587, 1942, 2162, 4208, 3]}, "items": [{"id": "p_3681", "content": "Optic Nerve Diseases [SEP] Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component o", "score": 1, "type": null, "tokenized_content": [2, 10109, 5507, 3902, 3, 2961, 2154, 5074, 4047, 2014, 5273, 1927, 1920, 2812, 13598, 2014, 10109, 5507, 16, 2154, 1977, 4933, 3311, 43, 4594, 57, 3]}]}
{"query": {"id": "q_3682", "content": "Epileptic seizures [SEP] Epileptic seizures following cortical application of fibrin sealants containing tr", "tokenized_content": [2, 16304, 10060, 3, 16304, 10060, 2894, 5586, 4722, 1927, 9450, 11652, 2356, 3165, 2025, 3]}, "items": [{"id": "p_3682", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_3683", "content": "tranexamic acid [SEP] es following cortical application of fibrin sealants containing tranexamic acid in rats.", "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 2376, 2894, 5586, 4722, 1927, 9450, 11652, 2356, 3165, 29808, 2783, 13514, 2687, 1922, 3615, 18, 3]}, "items": [{"id": "p_3683", "content": "Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 12244, 3693, 21092, 4274, 30077, 2251, 1922, 4010, 10489, 18, 3]}]}
{"query": {"id": "q_3684", "content": "tranexamic acid [SEP]  inhibitor. Recently, synthetic fibrinolysis inhibitors such as tranexamic acid (tAMCA) have been considered as substitutes for aprotinin. Howe", "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 4106, 18, 3998, 16, 6830, 9450, 6892, 4472, 2427, 1966, 29808, 2783, 13514, 2687, 12, 9066, 3375, 13, 2162, 2252, 3311, 1966, 18336, 1036, 1958, 3]}, "items": [{"id": "p_3684", "content": "Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 12244, 3693, 21092, 4274, 30077, 2251, 1922, 4010, 10489, 18, 3]}]}
{"query": {"id": "q_3685", "content": "tAMCA [SEP] tly, synthetic fibrinolysis inhibitors such as tranexamic acid (tAMCA) have been considered as substitutes for aprotinin. However, tA", "tokenized_content": [2, 9066, 3375, 3, 10474, 1012, 16, 6830, 9450, 6892, 4472, 2427, 1966, 29808, 2783, 13514, 2687, 12, 9066, 3375, 13, 2162, 2252, 3311, 1966, 18336, 1036, 1958, 25886, 18, 2406, 3]}, "items": [{"id": "p_3685", "content": "Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 12244, 3693, 21092, 4274, 30077, 2251, 1922, 4010, 10489, 18, 3]}]}
{"query": {"id": "q_3686", "content": "epileptic seizures [SEP] bstitutes for aprotinin. However, tAMCA has been shown to cause epileptic seizures. We wanted to study whether tAMCA retains its convulsive action", "tokenized_content": [2, 16304, 10060, 3, 24599, 4219, 14652, 1958, 25886, 18, 2406, 16, 9066, 3375, 2258, 2252, 2522, 1942, 3936, 16304, 10060, 18, 2038, 14624, 1942, 2161, 3053, 9066, 3375, 21645, 2496, 3]}, "items": [{"id": "p_3686", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_3687", "content": "convulsive [SEP] pileptic seizures. We wanted to study whether tAMCA retains its convulsive action if incorporated into a FS. METHOD: FS containing aprotin", "tokenized_content": [2, 4772, 13042, 3, 7547, 17920, 10060, 18, 2038, 14624, 1942, 2161, 3053, 9066, 3375, 21645, 2496, 4772, 13042, 4615, 2647, 8800, 2460, 43, 8612, 18, 2417, 30, 8612, 3165, 24309, 3]}, "items": [{"id": "p_3687", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3688", "content": "seizures [SEP] for aprotinin. However, tAMCA has been shown to cause epileptic seizures. We wanted to study whether tAMCA retains its convulsive action", "tokenized_content": [2, 10060, 3, 1958, 25886, 18, 2406, 16, 9066, 3375, 2258, 2252, 2522, 1942, 3936, 16304, 10060, 18, 2038, 14624, 1942, 2161, 3053, 9066, 3375, 21645, 2496, 4772, 13042, 4615, 3]}, "items": [{"id": "p_3688", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3689", "content": "generalized seizures [SEP] entration of tAMCA. Thus, FS containing 47.5 mg/ml tAMCA evoked generalized seizures in all tested rats (n=6) while the lowest concentration of tAMC", "tokenized_content": [2, 9612, 10060, 3, 5695, 1943, 1927, 9066, 3375, 18, 2842, 16, 8612, 3165, 4261, 18, 25, 2786, 19, 2646, 9066, 3375, 8782, 9612, 10060, 1922, 2136, 3620, 3615, 12, 56, 3]}, "items": [{"id": "p_3689", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3690", "content": "Tranexamic acid [SEP] protinin did not evoke any paroxysmal activity. INTERPRETATION: Tranexamic acid retains its convulsive action within FS. Thus, use of FS contai", "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 2844, 15020, 2811, 2084, 24074, 2967, 28033, 2455, 18, 6332, 30, 29808, 2783, 13514, 2687, 21645, 2496, 4772, 13042, 4615, 2651, 8612, 18, 2842, 16, 3]}, "items": [{"id": "p_3690", "content": "Tranexamic Acid [SEP] Antifibrinolytic hemostatic used in severe hemorrhage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29808, 2783, 13514, 2687, 3, 12244, 3693, 21092, 4274, 30077, 2251, 1922, 4010, 10489, 18, 3]}]}
{"query": {"id": "q_3691", "content": "sugar dependency [SEP] A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetam", "tokenized_content": [2, 9523, 14604, 3, 43, 3986, 7356, 9523, 14604, 5092, 5343, 3567, 17, 12770, 1942, 43, 2330, 3253, 1927, 9141, 9215, 1035, 3]}, "items": [{"id": "p_3691", "content": "Substance-Related Disorders [SEP] Disorders related to substance abuse.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7311, 17, 2712, 4414, 3, 4414, 2712, 1942, 7311, 7764, 18, 3]}]}
{"query": {"id": "q_3692", "content": "behavioral cross-sensitization [SEP] A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine.", "tokenized_content": [2, 5343, 3567, 17, 12770, 3, 43, 3986, 7356, 9523, 14604, 5092, 5343, 3567, 17, 12770, 1942, 43, 2330, 3253, 1927, 19057, 18, 3]}, "items": [{"id": "p_3692", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_3693", "content": "amphetamine [SEP] pendency causes behavioral cross-sensitization to a low dose of amphetamine.", "tokenized_content": [2, 19057, 3, 26127, 2589, 5092, 5343, 3567, 17, 12770, 1942, 43, 2330, 3253, 1927, 19057, 18, 3]}, "items": [{"id": "p_3693", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_3694", "content": "drug dependency [SEP] duces a state with neurochemical and behavioral similarities to drug dependency. The present study examined whether female rats on various regi", "tokenized_content": [2, 2838, 14604, 3, 10677, 1918, 43, 3360, 1956, 27297, 1930, 5343, 10857, 1942, 2838, 14604, 18, 1920, 2481, 2161, 3572, 3053, 4232, 3615, 1990, 3425, 2147, 1033, 3]}, "items": [{"id": "p_3694", "content": "Substance-Related Disorders [SEP] Disorders related to substance abuse.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7311, 17, 2712, 4414, 3, 4414, 2712, 1942, 7311, 7764, 18, 3]}]}
{"query": {"id": "q_3695", "content": "behavioral cross-sensitization [SEP] ther female rats on various regimens of sugar access would show behavioral cross-sensitization to a low dose of amphetamine. After a 30-min baseline measure o", "tokenized_content": [2, 5343, 3567, 17, 12770, 3, 2704, 4232, 3615, 1990, 3425, 9922, 1927, 9523, 4065, 2962, 2146, 5343, 3567, 17, 12770, 1942, 43, 2330, 3253, 1927, 19057, 18, 2256, 43, 2627, 3]}, "items": [{"id": "p_3695", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_3696", "content": "amphetamine [SEP] cess would show behavioral cross-sensitization to a low dose of amphetamine. After a 30-min baseline measure of locomotor activity (day 0),", "tokenized_content": [2, 19057, 3, 10897, 2962, 2146, 5343, 3567, 17, 12770, 1942, 43, 2330, 3253, 1927, 19057, 18, 2256, 43, 2627, 17, 2360, 3703, 2931, 1927, 13594, 2455, 12, 3007, 20, 13, 3]}, "items": [{"id": "p_3696", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_3697", "content": "sucrose [SEP]  cyclic diet of 12-h deprivation followed by 12-h access to 10% sucrose solution and chow pellets (12 h access starting 4 h after onset", "tokenized_content": [2, 8819, 3, 9821, 3986, 1927, 2369, 17, 50, 10837, 3489, 2007, 2369, 17, 50, 4065, 1942, 2119, 9, 8819, 3331, 1930, 15315, 12594, 12, 2369, 50, 4065, 6801, 24, 50, 3]}, "items": [{"id": "p_3697", "content": "Sucrose [SEP] A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from ", "score": 1, "type": null, "tokenized_content": [2, 8819, 3, 43, 28309, 2219, 1941, 2054, 9466, 7179, 1927, 3817, 1930, 15102, 4624, 3454, 2310, 28976, 9213, 1935, 24635, 18, 2176, 1977, 2926, 11177, 2037, 3]}]}
{"query": {"id": "q_3698", "content": "hyperactive [SEP] . The animals that had experienced cyclic sucrose and chow were hyperactive in response to amphetamine compared with four control groups (a", "tokenized_content": [2, 28704, 3, 18, 1920, 3555, 1988, 2430, 6090, 9821, 8819, 1930, 15315, 1985, 28704, 1922, 2644, 1942, 19057, 2452, 1956, 3006, 2285, 2671, 12, 43, 3]}, "items": [{"id": "p_3698", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_3699", "content": "dopamine [SEP] ity to amphetamine, possibly due to a lasting alteration in the dopamine system.", "tokenized_content": [2, 7964, 3, 2176, 1012, 1942, 19057, 16, 6553, 2810, 1942, 43, 11671, 10076, 1922, 1920, 7964, 2433, 18, 3]}, "items": [{"id": "p_3699", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3700", "content": "D-penicillamine [SEP] D-penicillamine-induced angiopathy in rats. The effect of high dose D-penicilla", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 46, 17, 25142, 3812, 17, 2719, 29220, 9112, 1012, 1922, 3615, 18, 1920, 2495, 1927, 2149, 3253, 46, 17, 25142, 1019, 3]}, "items": [{"id": "p_3700", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_3701", "content": "angiopathy [SEP] D-penicillamine-induced angiopathy in rats. The effect of high dose D-penicillamine treatment on a", "tokenized_content": [2, 29220, 9112, 1012, 3, 46, 17, 25142, 3812, 17, 2719, 29220, 9112, 1012, 1922, 3615, 18, 1920, 2495, 1927, 2149, 3253, 46, 17, 25142, 3812, 2311, 1990, 43, 3]}, "items": [{"id": "p_3701", "content": "Aortic Diseases [SEP] Pathological processes involving any part of the AORTA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7677, 3902, 3, 6598, 4028, 5884, 2967, 3131, 1927, 1920, 11859, 18, 3]}]}
{"query": {"id": "q_3702", "content": "D-penicillamine [SEP] Male Sprague-Dawley rats were treated with D-penicillamine (D-pen) 500 mg/kg/day for 10 or 42 days. Pair fed rats served a", "tokenized_content": [2, 46, 17, 25142, 3812, 3, 4005, 15684, 17, 15798, 3615, 1985, 2868, 1956, 46, 17, 25142, 3812, 12, 46, 17, 4959, 13, 4599, 2786, 19, 3621, 19, 3007, 1958, 2119, 3]}, "items": [{"id": "p_3702", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_3703", "content": "D-pen [SEP] Male Sprague-Dawley rats were treated with D-penicillamine (D-pen) 500 mg/kg/day for 10 or 42 days. Pair fed rat", "tokenized_content": [2, 46, 17, 4959, 3, 4005, 15684, 17, 15798, 3615, 1985, 2868, 1956, 46, 17, 25142, 3812, 12, 46, 17, 4959, 13, 4599, 2786, 19, 3621, 19, 3007, 1958, 2119, 2014, 3]}, "items": [{"id": "p_3703", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_3704", "content": "hyaluronate [SEP] er which may be caused by a steric exclusion effect of abundant hyaluronate. The endothelial ultrastructure was unaffected by D-pen, and no", "tokenized_content": [2, 22825, 2010, 3, 2668, 2154, 2278, 1998, 4189, 2007, 43, 17638, 7901, 2495, 1927, 7437, 22825, 2010, 18, 1920, 5003, 26708, 1982, 10403, 2007, 46, 17, 4959, 16, 1930, 2239, 3]}, "items": [{"id": "p_3704", "content": "Hyaluronic Acid [SEP] A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is f", "score": 1, "type": null, "tokenized_content": [2, 27857, 2687, 3, 43, 4613, 2149, 17, 13869, 3422, 13580, 9466, 1956, 17403, 4666, 12, 21, 17, 23, 13, 29306, 1930, 4666, 12, 21, 17, 24, 13, 3351, 5360, 8547, 12546, 9031, 18, 2176, 1977, 48, 3]}]}
{"query": {"id": "q_3705", "content": "anthracycline [SEP] Brain natriuretic peptide is a predictor of anthracycline-induced cardiotoxicity.", "tokenized_content": [2, 30021, 3, 3068, 20434, 4207, 1977, 43, 7837, 1927, 30021, 17, 2719, 30490, 18, 3]}, "items": [{"id": "p_3705", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_3706", "content": "cardiotoxicity [SEP] ain natriuretic peptide is a predictor of anthracycline-induced cardiotoxicity.", "tokenized_content": [2, 30490, 3, 9798, 1022, 20434, 4207, 1977, 43, 7837, 1927, 30021, 17, 2719, 30490, 18, 3]}, "items": [{"id": "p_3706", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3707", "content": "Anthracyclines [SEP] Anthracyclines are effective antineoplastic drugs, but they frequently cause d", "tokenized_content": [2, 30021, 1036, 3, 30021, 1036, 2032, 3655, 29128, 9969, 4195, 16, 2308, 2611, 5467, 3936, 46, 3]}, "items": [{"id": "p_3707", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_3708", "content": "cardiotoxicity [SEP] ve antineoplastic drugs, but they frequently cause dose-related cardiotoxicity. The cardiotoxicity of conventional anthracycline therapy highl", "tokenized_content": [2, 30490, 3, 3428, 29128, 9969, 4195, 16, 2308, 2611, 5467, 3936, 3253, 17, 2712, 30490, 18, 1920, 30490, 1927, 5552, 30021, 3181, 5271, 3]}, "items": [{"id": "p_3708", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_3709", "content": "anthracycline [SEP] dose-related cardiotoxicity. The cardiotoxicity of conventional anthracycline therapy highlights a need to search for methods that are highly", "tokenized_content": [2, 30021, 3, 3253, 17, 2712, 30490, 18, 1920, 30490, 1927, 5552, 30021, 3181, 10668, 43, 2942, 1942, 4603, 1958, 2860, 1988, 2032, 3626, 3]}, "items": [{"id": "p_3709", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_3710", "content": "cardiac dysfunction [SEP] for methods that are highly sensitive and capable of predicting cardiac dysfunction. We measured the plasma level of brain natriuretic peptide (BNP", "tokenized_content": [2, 4435, 5273, 3, 1958, 2860, 1988, 2032, 3626, 4532, 1930, 7131, 1927, 8779, 4435, 5273, 18, 2038, 3045, 1920, 3582, 2237, 1927, 3068, 20434, 4207, 12, 18813, 3]}, "items": [{"id": "p_3710", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_3711", "content": "acute leukemia [SEP] icator of anthracycline-induced cardiotoxicity in patients with acute leukemia treated with a daunorubicin (DNR)-containing regimen. Thirteen ", "tokenized_content": [2, 3939, 8111, 3, 14784, 2684, 1927, 30021, 17, 2719, 30490, 1922, 2132, 1956, 3939, 8111, 2868, 1956, 43, 3692, 1983, 11891, 12, 5956, 1005, 13, 17, 3165, 8607, 18, 18468, 3]}, "items": [{"id": "p_3711", "content": "Leukemia, Myeloid, Acute [SEP] Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 9677, 16, 3939, 3, 11597, 7013, 1927, 9677, 25237, 1922, 3622, 6599, 16, 2877, 16, 1930, 2303, 2960, 18, 9677, 29250, 2392, 2037, 2840, 1922, 2094, 1988, 3]}]}
{"query": {"id": "q_3712", "content": "daunorubicin [SEP] d cardiotoxicity in patients with acute leukemia treated with a daunorubicin (DNR)-containing regimen. Thirteen patients with acute leukemia", "tokenized_content": [2, 3692, 1983, 11891, 3, 46, 30490, 1922, 2132, 1956, 3939, 8111, 2868, 1956, 43, 3692, 1983, 11891, 12, 5956, 1005, 13, 17, 3165, 8607, 18, 18468, 2132, 1956, 3939, 8111, 3]}, "items": [{"id": "p_3712", "content": "Daunorubicin [SEP] A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of L", "score": 1, "type": null, "tokenized_content": [2, 3692, 1983, 11891, 3, 43, 3345, 6161, 30021, 23029, 8028, 29128, 9969, 3937, 2037, 22874, 2737, 3005, 1914, 1957, 1930, 4991, 16, 2251, 1922, 2311, 1927, 54, 3]}]}
{"query": {"id": "q_3713", "content": "DNR [SEP] ty in patients with acute leukemia treated with a daunorubicin (DNR)-containing regimen. Thirteen patients with acute leukemia were", "tokenized_content": [2, 5956, 1005, 3, 6227, 1922, 2132, 1956, 3939, 8111, 2868, 1956, 43, 3692, 1983, 11891, 12, 5956, 1005, 13, 17, 3165, 8607, 18, 18468, 2132, 1956, 3939, 8111, 1985, 3]}, "items": [{"id": "p_3713", "content": "Daunorubicin [SEP] A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of L", "score": 1, "type": null, "tokenized_content": [2, 3692, 1983, 11891, 3, 43, 3345, 6161, 30021, 23029, 8028, 29128, 9969, 3937, 2037, 22874, 2737, 3005, 1914, 1957, 1930, 4991, 16, 2251, 1922, 2311, 1927, 54, 3]}]}
{"query": {"id": "q_3714", "content": "congestive heart failure [SEP]  the time of radionuclide angiography. Three patients developed congestive heart failure after the completion of chemotherapy. Five patients were diagno", "tokenized_content": [2, 20180, 4003, 4574, 3, 1920, 2367, 1927, 29428, 11676, 18, 2559, 2132, 3530, 20180, 4003, 4574, 2256, 1920, 9297, 1927, 5318, 18, 3628, 2132, 1985, 2822, 1037, 3]}, "items": [{"id": "p_3714", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_3715", "content": "heart failure [SEP] f radionuclide angiography. Three patients developed congestive heart failure after the completion of chemotherapy. Five patients were diagno", "tokenized_content": [2, 4003, 4574, 3, 48, 29428, 11676, 18, 2559, 2132, 3530, 20180, 4003, 4574, 2256, 1920, 9297, 1927, 5318, 18, 3628, 2132, 1985, 2822, 1037, 3]}, "items": [{"id": "p_3715", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_3716", "content": "birth defects [SEP] Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study.", "tokenized_content": [2, 5043, 6007, 3, 13021, 6093, 2485, 2409, 5284, 1930, 2565, 1927, 5043, 6007, 30, 3852, 5043, 6007, 5455, 2161, 18, 3]}, "items": [{"id": "p_3716", "content": "Abnormalities, Drug-Induced [SEP] Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is in", "score": 1, "type": null, "tokenized_content": [2, 6754, 16, 2838, 17, 2719, 3, 9901, 6754, 4189, 2007, 15033, 10054, 2014, 4195, 1927, 7764, 3258, 1942, 2014, 4208, 2007, 1920, 7999, 16, 2014, 1942, 2154, 4693, 1977, 1922, 3]}]}
{"query": {"id": "q_3717", "content": "Birth Defects [SEP] cation use during pregnancy and risk of birth defects: National Birth Defects Prevention Study.", "tokenized_content": [2, 5043, 6007, 3, 9976, 2485, 2409, 5284, 1930, 2565, 1927, 5043, 6007, 30, 3852, 5043, 6007, 5455, 2161, 18, 3]}, "items": [{"id": "p_3717", "content": "Abnormalities, Drug-Induced [SEP] Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is in", "score": 1, "type": null, "tokenized_content": [2, 6754, 16, 2838, 17, 2719, 3, 9901, 6754, 4189, 2007, 15033, 10054, 2014, 4195, 1927, 7764, 3258, 1942, 2014, 4208, 2007, 1920, 7999, 16, 2014, 1942, 2154, 4693, 1977, 1922, 3]}]}
{"query": {"id": "q_3718", "content": "birth defects [SEP]  the association between antibacterial medications and selected birth defects. DESIGN, SETTING, AND PARTICIPANTS: Population-based, multisite", "tokenized_content": [2, 5043, 6007, 3, 1920, 3279, 2192, 13021, 7719, 1930, 3790, 5043, 6007, 18, 3036, 16, 4308, 16, 1930, 3003, 30, 2973, 17, 2454, 16, 13564, 2394, 3]}, "items": [{"id": "p_3718", "content": "Abnormalities, Drug-Induced [SEP] Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is in", "score": 1, "type": null, "tokenized_content": [2, 6754, 16, 2838, 17, 2719, 3, 9901, 6754, 4189, 2007, 15033, 10054, 2014, 4195, 1927, 7764, 3258, 1942, 2014, 4208, 2007, 1920, 7999, 16, 2014, 1942, 2154, 4693, 1977, 1922, 3]}]}
{"query": {"id": "q_3719", "content": "birth defect [SEP]  the association between antibacterial medications and selected birth defects. DESIGN, SETTING, AND PARTICIPANTS: Population-based, multisit", "tokenized_content": [2, 5043, 7374, 3, 1920, 3279, 2192, 13021, 7719, 1930, 3790, 5043, 6007, 18, 3036, 16, 4308, 16, 1930, 3003, 30, 2973, 17, 2454, 16, 13564, 1932, 3]}, "items": [{"id": "p_3719", "content": "Abnormalities, Drug-Induced [SEP] Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is in", "score": 1, "type": null, "tokenized_content": [2, 6754, 16, 2838, 17, 2719, 3, 9901, 6754, 4189, 2007, 15033, 10054, 2014, 4195, 1927, 7764, 3258, 1942, 2014, 4208, 2007, 1920, 7999, 16, 2014, 1942, 2154, 4693, 1977, 1922, 3]}]}
{"query": {"id": "q_3720", "content": "Sulfonamides [SEP] als increased during pregnancy, peaking during the third month. Sulfonamides were associated with anencephaly (adjusted OR [AOR] = 3.4; 95% ", "tokenized_content": [2, 26265, 20381, 3, 10534, 2502, 2409, 5284, 16, 29715, 2409, 1920, 4563, 2935, 18, 26265, 20381, 1985, 2458, 1956, 9860, 15895, 2128, 7289, 1012, 12, 4967, 2014, 37, 14973, 39, 3]}, "items": [{"id": "p_3720", "content": "Sulfonamides [SEP] A group of compounds that contain the structure SO2NH2.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26265, 20381, 3, 43, 2210, 1927, 4300, 1988, 5531, 1920, 3170, 25119, 21677, 1028, 18, 3]}]}
{"query": {"id": "q_3721", "content": "anencephaly [SEP] aking during the third month. Sulfonamides were associated with anencephaly (adjusted OR [AOR] = 3.4; 95% confidence interval [CI], 1.3-8.8", "tokenized_content": [2, 9860, 15895, 2128, 7289, 1012, 3, 26162, 1029, 2409, 1920, 4563, 2935, 18, 26265, 20381, 1985, 2458, 1956, 9860, 15895, 2128, 7289, 1012, 12, 4967, 2014, 37, 14973, 39, 33, 3]}, "items": [{"id": "p_3721", "content": "Anencephaly [SEP] A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal c", "score": 1, "type": null, "tokenized_content": [2, 9860, 15895, 2128, 7289, 1012, 3, 43, 22138, 1927, 1920, 7580, 2433, 4189, 2007, 4574, 1927, 1920, 5477, 13889, 2073, 1942, 5428, 18, 5969, 2032, 8813, 1956, 6718, 6071, 45, 3]}]}
{"query": {"id": "q_3722", "content": "hypoplastic left heart syndrome [SEP] djusted OR [AOR] = 3.4; 95% confidence interval [CI], 1.3-8.8), hypoplastic left heart syndrome (AOR = 3.2; 95% CI, 1.3-7.6), coarctation of the aorta (AOR = 2", "tokenized_content": [2, 26497, 24605, 2002, 3506, 4003, 4741, 3, 17224, 13940, 2014, 37, 14973, 39, 33, 23, 18, 24, 31, 3002, 9, 5203, 4979, 37, 3371, 39, 16, 21, 18, 23, 17, 3]}, "items": [{"id": "p_3722", "content": "Hypoplastic Left Heart Syndrome [SEP] A condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardia", "score": 1, "type": null, "tokenized_content": [2, 26497, 24605, 2002, 3506, 4003, 4741, 3, 43, 2625, 4189, 2007, 2441, 3695, 2374, 2017, 1927, 1920, 4292, 3506, 4768, 1927, 1920, 4003, 18, 2176, 1977, 4378, 2007, 25502, 1927, 1920, 3506, 3215, 1019, 3]}]}
{"query": {"id": "q_3723", "content": "coarctation of the aorta [SEP] , hypoplastic left heart syndrome (AOR = 3.2; 95% CI, 1.3-7.6), coarctation of the aorta (AOR = 2.7; 95% CI, 1.3-5.6), choanal atresia (AOR = 8.0; 95% C", "tokenized_content": [2, 10027, 15618, 4926, 1927, 1920, 11859, 3, 16, 26497, 24605, 2002, 3506, 4003, 4741, 12, 14973, 33, 23, 18, 22, 31, 3002, 9, 3371, 16, 21, 18, 23, 17, 27, 3]}, "items": [{"id": "p_3723", "content": "Aortic Coarctation [SEP] A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse ar", "score": 1, "type": null, "tokenized_content": [2, 7677, 10027, 15618, 4926, 3, 43, 5043, 7374, 4378, 2007, 1920, 21005, 1927, 1920, 11859, 1988, 2112, 1998, 1927, 7155, 4647, 1930, 2019, 2967, 3575, 2037, 1920, 11740, 2245, 3]}]}
{"query": {"id": "q_3724", "content": "choanal atresia [SEP] .3-7.6), coarctation of the aorta (AOR = 2.7; 95% CI, 1.3-5.6), choanal atresia (AOR = 8.0; 95% CI, 2.7-23.5), transverse limb deficiency (AOR ", "tokenized_content": [2, 4551, 10927, 29211, 3, 18, 23, 17, 27, 18, 26, 13, 16, 10027, 15618, 4926, 1927, 1920, 11859, 12, 14973, 33, 22, 18, 27, 31, 3002, 9, 3371, 16, 21, 3]}, "items": [{"id": "p_3724", "content": "Choanal Atresia [SEP] A congenital abnormality that is characterized by a blocked CHOANAE, the opening between the nose and the NASOPHARYNX. Blockage ", "score": 1, "type": null, "tokenized_content": [2, 4551, 10927, 29211, 3, 43, 9901, 14311, 1988, 1977, 4378, 2007, 43, 6923, 4551, 7241, 1021, 16, 1920, 9497, 2192, 1920, 16427, 1930, 1920, 7312, 2688, 15792, 18, 23615, 3]}]}
{"query": {"id": "q_3725", "content": "transverse limb deficiency [SEP] 5% CI, 1.3-5.6), choanal atresia (AOR = 8.0; 95% CI, 2.7-23.5), transverse limb deficiency (AOR = 2.5; 95% CI, 1.0-5.9), and diaphragmatic hernia (AOR = 2", "tokenized_content": [2, 11740, 7755, 6179, 3, 25, 9, 3371, 16, 21, 18, 23, 17, 25, 18, 26, 13, 16, 4551, 10927, 29211, 12, 14973, 33, 28, 18, 20, 31, 3002, 9, 3371, 3]}, "items": [{"id": "p_3725", "content": "Limb Deformities, Congenital [SEP] Congenital structural deformities of the upper and lower extremities collectively or unspecified.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7755, 26224, 16, 9901, 3, 9901, 4346, 26224, 1927, 1920, 5199, 1930, 2826, 18884, 10182, 2014, 29628, 2828, 18, 3]}]}
{"query": {"id": "q_3726", "content": "diaphragmatic hernia [SEP] ), transverse limb deficiency (AOR = 2.5; 95% CI, 1.0-5.9), and diaphragmatic hernia (AOR = 2.4; 95% CI, 1.1-5.4). Nitrofurantoins were associated w", "tokenized_content": [2, 29896, 17700, 3, 13, 16, 11740, 7755, 6179, 12, 14973, 33, 22, 18, 25, 31, 3002, 9, 3371, 16, 21, 18, 20, 17, 25, 18, 29, 13, 16, 1930, 29896, 3]}, "items": [{"id": "p_3726", "content": "Hernia, Diaphragmatic [SEP] Protrusion of abdominal structures into the THORAX as a result of congenital or traumatic defects in the respiratory DIAPHRAGM.\n", "score": 1, "type": null, "tokenized_content": [2, 17700, 16, 29896, 3, 24384, 1927, 6900, 4061, 2460, 1920, 23755, 1966, 43, 3211, 1927, 9901, 2014, 10242, 6007, 1922, 1920, 5481, 16108, 18, 3]}]}
{"query": {"id": "q_3727", "content": "Nitrofurantoins [SEP] .0-5.9), and diaphragmatic hernia (AOR = 2.4; 95% CI, 1.1-5.4). Nitrofurantoins were associated with anophthalmia or microphthalmos (AOR = 3.7;", "tokenized_content": [2, 8686, 29579, 4575, 2925, 3, 18, 20, 17, 25, 18, 29, 13, 16, 1930, 29896, 17700, 12, 14973, 33, 22, 18, 24, 31, 3002, 9, 3371, 16, 21, 18, 21, 3]}, "items": [{"id": "p_3727", "content": "Nitrofurantoin [SEP] A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antib", "score": 1, "type": null, "tokenized_content": [2, 8686, 29579, 4575, 1921, 3, 43, 7075, 2246, 17, 20905, 5899, 3655, 3316, 2501, 8604, 17, 2843, 1930, 8604, 17, 3136, 7373, 18, 2876, 26265, 20381, 1930, 2727, 3]}]}
{"query": {"id": "q_3728", "content": "anophthalmia [SEP] R = 2.4; 95% CI, 1.1-5.4). Nitrofurantoins were associated with anophthalmia or microphthalmos (AOR = 3.7; 95% CI, 1.1-12.2), hypoplastic le", "tokenized_content": [2, 21969, 27980, 2126, 3, 60, 33, 22, 18, 24, 31, 3002, 9, 3371, 16, 21, 18, 21, 17, 25, 18, 24, 13, 18, 8686, 29579, 4575, 2925, 1985, 2458, 1956, 3]}, "items": [{"id": "p_3728", "content": "Anophthalmos [SEP] Congenital absence of the eye or eyes.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21969, 27980, 1951, 3, 9901, 3905, 1927, 1920, 5723, 2014, 7127, 18, 3]}]}
{"query": {"id": "q_3729", "content": "microphthalmos [SEP]  1.1-5.4). Nitrofurantoins were associated with anophthalmia or microphthalmos (AOR = 3.7; 95% CI, 1.1-12.2), hypoplastic left heart syndrome ", "tokenized_content": [2, 18274, 19253, 7289, 12492, 1036, 3, 21, 18, 21, 17, 25, 18, 24, 13, 18, 8686, 29579, 4575, 2925, 1985, 2458, 1956, 21969, 27980, 2126, 2014, 18274, 19253, 7289, 12492, 3]}, "items": [{"id": "p_3729", "content": "Microphthalmos [SEP] Congenital or developmental anomaly in which the eyeballs are abnormally small.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18274, 19253, 7289, 12492, 1036, 3, 9901, 2014, 5878, 20950, 1922, 2154, 1920, 5723, 16344, 1036, 2032, 20756, 2858, 18, 3]}]}
{"query": {"id": "q_3730", "content": "atrial septal defects [SEP] , hypoplastic left heart syndrome (AOR = 4.2; 95% CI, 1.9-9.1), atrial septal defects (AOR = 1.9; 95% CI, 1.1-3.4), and cleft lip with cleft palate (", "tokenized_content": [2, 9224, 16458, 6007, 3, 16, 26497, 24605, 2002, 3506, 4003, 4741, 12, 14973, 33, 24, 18, 22, 31, 3002, 9, 3371, 16, 21, 18, 29, 17, 29, 18, 21, 13, 3]}, "items": [{"id": "p_3730", "content": "Heart Septal Defects, Atrial [SEP] Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chamb", "score": 1, "type": null, "tokenized_content": [2, 4003, 16458, 6007, 16, 9224, 3, 5878, 6754, 1922, 2967, 7717, 1927, 1920, 9224, 17026, 3864, 1922, 4552, 20518, 2192, 1920, 2288, 5199, 6361, 1014, 3]}]}
{"query": {"id": "q_3731", "content": "cleft lip [SEP] 9-9.1), atrial septal defects (AOR = 1.9; 95% CI, 1.1-3.4), and cleft lip with cleft palate (AOR = 2.1; 95% CI, 1.2-3.9). Other antibacte", "tokenized_content": [2, 14649, 3178, 3, 29, 17, 29, 18, 21, 13, 16, 9224, 16458, 6007, 12, 14973, 33, 21, 18, 29, 31, 3002, 9, 3371, 16, 21, 18, 21, 17, 23, 18, 3]}, "items": [{"id": "p_3731", "content": "Cleft Lip [SEP] Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is", "score": 1, "type": null, "tokenized_content": [2, 14649, 3178, 3, 9901, 7374, 1922, 1920, 5199, 3178, 2597, 1920, 15813, 8057, 2055, 16300, 1942, 27399, 1956, 1920, 15780, 7922, 9305, 8057, 2408, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_3732", "content": "cleft palate [SEP] septal defects (AOR = 1.9; 95% CI, 1.1-3.4), and cleft lip with cleft palate (AOR = 2.1; 95% CI, 1.2-3.9). Other antibacterial agents that s", "tokenized_content": [2, 14649, 19471, 3, 16458, 6007, 12, 14973, 33, 21, 18, 29, 31, 3002, 9, 3371, 16, 21, 18, 21, 17, 23, 18, 24, 13, 16, 1930, 14649, 3178, 1956, 14649, 3]}, "items": [{"id": "p_3732", "content": "Cleft Palate [SEP] Congenital fissure of the soft and/or hard palate, due to faulty fusion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14649, 19471, 3, 9901, 6255, 20490, 1936, 1927, 1920, 3793, 1930, 19, 2014, 6986, 19471, 16, 2810, 1942, 21971, 1012, 5289, 18, 3]}]}
{"query": {"id": "q_3733", "content": "erythromycins [SEP] ). Other antibacterial agents that showed associations included erythromycins (2 defects), penicillins (1 defect), cephalosporins (1 defect),", "tokenized_content": [2, 22925, 1036, 3, 13, 18, 2303, 13021, 4820, 1988, 2594, 5253, 3063, 22925, 1036, 12, 22, 6007, 13, 16, 9957, 1036, 12, 21, 7374, 13, 16, 25091, 2925, 12, 21, 3]}, "items": [{"id": "p_3733", "content": "Erythromycin [SEP] A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active componen", "score": 1, "type": null, "tokenized_content": [2, 22925, 3, 43, 14027, 14882, 7267, 23929, 2261, 4152, 2007, 22874, 6549, 1936, 1957, 18, 22925, 43, 1977, 3311, 2496, 3044, 3500, 3309, 1917, 3]}]}
{"query": {"id": "q_3734", "content": "penicillins [SEP] ts that showed associations included erythromycins (2 defects), penicillins (1 defect), cephalosporins (1 defect), and quinolones (1 defect", "tokenized_content": [2, 9957, 1036, 3, 4894, 1988, 2594, 5253, 3063, 22925, 1036, 12, 22, 6007, 13, 16, 9957, 1036, 12, 21, 7374, 13, 16, 25091, 2925, 12, 21, 7374, 13, 16, 1930, 3]}, "items": [{"id": "p_3734", "content": "Penicillins [SEP] A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nuc", "score": 1, "type": null, "tokenized_content": [2, 9957, 1036, 3, 43, 2210, 1927, 7560, 1988, 5531, 26, 17, 3835, 17125, 2478, 11560, 19510, 2687, 1956, 43, 4159, 4659, 8765, 1942, 1920, 26, 17, 3835, 2210, 18, 1920, 9957, 25020, 3]}]}
{"query": {"id": "q_3735", "content": "cephalosporins [SEP] ons included erythromycins (2 defects), penicillins (1 defect), cephalosporins (1 defect), and quinolones (1 defect). CONCLUSIONS: Reassuringl", "tokenized_content": [2, 25091, 2925, 3, 24335, 3063, 22925, 1036, 12, 22, 6007, 13, 16, 9957, 1036, 12, 21, 7374, 13, 16, 25091, 2925, 12, 21, 7374, 13, 16, 1930, 9012, 24909, 12, 3]}, "items": [{"id": "p_3735", "content": "Cephalosporins [SEP] A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moie", "score": 1, "type": null, "tokenized_content": [2, 25091, 2925, 3, 43, 2210, 1927, 4949, 17, 5648, 7560, 2561, 3937, 2037, 1920, 16825, 16461, 10428, 1987, 15414, 18, 2611, 5531, 1920, 4666, 17, 15294, 15295, 1021, 3]}]}
{"query": {"id": "q_3736", "content": "quinolones [SEP] efects), penicillins (1 defect), cephalosporins (1 defect), and quinolones (1 defect). CONCLUSIONS: Reassuringly, penicillins, erythromyci", "tokenized_content": [2, 9012, 24909, 3, 8485, 2284, 13, 16, 9957, 1036, 12, 21, 7374, 13, 16, 25091, 2925, 12, 21, 7374, 13, 16, 1930, 9012, 24909, 12, 21, 7374, 13, 18, 4355, 3]}, "items": [{"id": "p_3736", "content": "Quinolones [SEP] A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9012, 24909, 3, 43, 2210, 1927, 8383, 1927, 23330, 3553, 5802, 18708, 2687, 16, 9012, 8419, 18708, 2687, 16, 2014, 13120, 13756, 18068, 1030, 2687, 18, 3]}]}
{"query": {"id": "q_3737", "content": "nitrofurantoins [SEP] , were not associated with many birth defects. Sulfonamides and nitrofurantoins were associated with several birth defects, indicating a need f", "tokenized_content": [2, 8686, 29579, 4575, 2925, 3, 16, 1985, 2084, 2458, 1956, 3086, 5043, 6007, 18, 26265, 20381, 1930, 8686, 29579, 4575, 2925, 1985, 2458, 1956, 2980, 5043, 6007, 16, 4168, 43, 3]}, "items": [{"id": "p_3737", "content": "Nitrofurantoin [SEP] A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antib", "score": 1, "type": null, "tokenized_content": [2, 8686, 29579, 4575, 1921, 3, 43, 7075, 2246, 17, 20905, 5899, 3655, 3316, 2501, 8604, 17, 2843, 1930, 8604, 17, 3136, 7373, 18, 2876, 26265, 20381, 1930, 2727, 3]}]}
{"query": {"id": "q_3738", "content": "neoplasms [SEP] Incidence of neoplasms in patients with rheumatoid arthritis exposed to different trea", "tokenized_content": [2, 15347, 3, 4332, 1927, 15347, 1922, 2132, 1956, 13053, 8884, 4616, 1942, 2413, 2171, 1019, 3]}, "items": [{"id": "p_3738", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3739", "content": "rheumatoid arthritis [SEP] Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens.", "tokenized_content": [2, 13053, 8884, 3, 4332, 1927, 15347, 1922, 2132, 1956, 13053, 8884, 4616, 1942, 2413, 2311, 9922, 18, 3]}, "items": [{"id": "p_3739", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_3740", "content": "rheumatoid arthritis [SEP] d during the last 30 years in treatment of patients with severe rheumatoid arthritis. The drugs commonly used are cyclophosphamide and chlorambucil ", "tokenized_content": [2, 13053, 8884, 3, 46, 2409, 1920, 4691, 2627, 2739, 1922, 2311, 1927, 2132, 1956, 4010, 13053, 8884, 18, 1920, 4195, 5384, 2251, 2032, 17135, 1930, 4891, 6739, 1978, 1970, 3]}, "items": [{"id": "p_3740", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_3741", "content": "cyclophosphamide [SEP] s with severe rheumatoid arthritis. The drugs commonly used are cyclophosphamide and chlorambucil (alkylating agents), azathioprine (purine anal", "tokenized_content": [2, 17135, 3, 61, 1956, 4010, 13053, 8884, 18, 1920, 4195, 5384, 2251, 2032, 17135, 1930, 4891, 6739, 1978, 1970, 12, 28912, 4820, 13, 16, 30499, 5773, 12, 19700, 2151, 3]}, "items": [{"id": "p_3741", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_3742", "content": "chlorambucil [SEP] oid arthritis. The drugs commonly used are cyclophosphamide and chlorambucil (alkylating agents), azathioprine (purine analogue), and methot", "tokenized_content": [2, 4891, 6739, 1978, 1970, 3, 25166, 1007, 8884, 18, 1920, 4195, 5384, 2251, 2032, 17135, 1930, 4891, 6739, 1978, 1970, 12, 28912, 4820, 13, 16, 30499, 5773, 12, 19700, 12980, 3]}, "items": [{"id": "p_3742", "content": "Chlorambucil [SEP] A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Alth", "score": 1, "type": null, "tokenized_content": [2, 4891, 6739, 1978, 1970, 3, 43, 6634, 4902, 2211, 28912, 5899, 2251, 1966, 29128, 9969, 1958, 3724, 18921, 8111, 16, 17447, 11, 61, 2573, 16, 1930, 4991, 18, 2874, 3]}]}
{"query": {"id": "q_3743", "content": "alkylating agents [SEP]  The drugs commonly used are cyclophosphamide and chlorambucil (alkylating agents), azathioprine (purine analogue), and methotrexate (folic acid ", "tokenized_content": [2, 28912, 4820, 3, 1920, 4195, 5384, 2251, 2032, 17135, 1930, 4891, 6739, 1978, 1970, 12, 28912, 4820, 13, 16, 30499, 5773, 12, 19700, 12980, 13, 16, 1930, 18031, 12, 19731, 3]}, "items": [{"id": "p_3743", "content": "Alkylating Agents [SEP] Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper func", "score": 1, "type": null, "tokenized_content": [2, 28912, 4820, 3, 3626, 6079, 10164, 1988, 11959, 13345, 12467, 2460, 12186, 3500, 4206, 1930, 6113, 4625, 2310, 3405, 2277, 1030, 3]}]}
{"query": {"id": "q_3744", "content": "azathioprine [SEP] used are cyclophosphamide and chlorambucil (alkylating agents), azathioprine (purine analogue), and methotrexate (folic acid analogue). Ther", "tokenized_content": [2, 30499, 5773, 3, 2251, 2032, 17135, 1930, 4891, 6739, 1978, 1970, 12, 28912, 4820, 13, 16, 30499, 5773, 12, 19700, 12980, 13, 16, 1930, 18031, 12, 19731, 2687, 12980, 13, 3]}, "items": [{"id": "p_3744", "content": "Azathioprine [SEP] An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 30499, 5773, 3, 1925, 12910, 5899, 2251, 1922, 3921, 1956, 17135, 1930, 8275, 11600, 1037, 15520, 1922, 1920, 2311, 1927, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_3745", "content": "purine [SEP] phosphamide and chlorambucil (alkylating agents), azathioprine (purine analogue), and methotrexate (folic acid analogue). There is evi", "tokenized_content": [2, 19700, 3, 2766, 5482, 1930, 4891, 6739, 1978, 1970, 12, 28912, 4820, 13, 16, 30499, 5773, 12, 19700, 12980, 13, 16, 1930, 18031, 12, 19731, 2687, 12980, 13, 18, 2276, 3]}, "items": [{"id": "p_3745", "content": "Purines [SEP] A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADE", "score": 1, "type": null, "tokenized_content": [2, 19700, 1036, 3, 43, 4696, 1927, 27804, 13153, 4300, 1988, 2032, 3425, 1954, 11798, 1922, 4899, 1930, 2032, 3171, 2222, 1966, 19700, 11137, 18, 2611, 3951, 23846, 3]}]}
{"query": {"id": "q_3746", "content": "methotrexate [SEP] mbucil (alkylating agents), azathioprine (purine analogue), and methotrexate (folic acid analogue). There is evidence that all four immunosu", "tokenized_content": [2, 18031, 3, 5667, 1978, 1970, 12, 28912, 4820, 13, 16, 30499, 5773, 12, 19700, 12980, 13, 16, 1930, 18031, 12, 19731, 2687, 12980, 13, 18, 2276, 1977, 3095, 1988, 2136, 3]}, "items": [{"id": "p_3746", "content": "Methotrexate [SEP] An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and pre", "score": 1, "type": null, "tokenized_content": [2, 18031, 3, 1925, 29128, 9969, 20330, 9215, 4627, 12191, 2057, 1956, 27996, 2031, 3879, 18, 2176, 1977, 1925, 4106, 1927, 21196, 27851, 9294, 1930, 2097, 3]}]}
{"query": {"id": "q_3747", "content": "folic acid [SEP] ting agents), azathioprine (purine analogue), and methotrexate (folic acid analogue). There is evidence that all four immunosuppressive dr", "tokenized_content": [2, 19731, 2687, 3, 12347, 1029, 4820, 13, 16, 30499, 5773, 12, 19700, 12980, 13, 16, 1930, 18031, 12, 19731, 2687, 12980, 13, 18, 2276, 1977, 3095, 1988, 2136, 3006, 12910, 3]}, "items": [{"id": "p_3747", "content": "Folic Acid [SEP] A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in", "score": 1, "type": null, "tokenized_content": [2, 19731, 2687, 3, 43, 7210, 1927, 1920, 6111, 44, 3416, 1988, 11803, 1920, 9960, 2433, 18, 2176, 1977, 2481, 1922, 1920, 3568, 1930, 5245, 1930, 1977, 2435, 1922, 3]}]}
{"query": {"id": "q_3748", "content": "synovitis [SEP] re is evidence that all four immunosuppressive drugs can reduce synovitis, but disease activity almost always recurs after therapy is sto", "tokenized_content": [2, 27481, 3600, 3, 1964, 1977, 3095, 1988, 2136, 3006, 12910, 4195, 2112, 4412, 27481, 3600, 16, 2308, 2573, 2455, 5365, 6789, 26861, 2256, 3181, 1977, 13046, 3]}, "items": [{"id": "p_3748", "content": "Synovitis [SEP] Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelli", "score": 1, "type": null, "tokenized_content": [2, 27481, 3600, 3, 4531, 1927, 43, 14828, 3260, 18, 2176, 1977, 5394, 15806, 16, 4443, 1990, 6269, 16, 1930, 1977, 4378, 2007, 43, 26138, 9736, 11560, 1033, 3]}]}
{"query": {"id": "q_3749", "content": "acute nonlymphocytic leukemia [SEP] with alkylating agents have an increased risk of development of acute nonlymphocytic leukemia, and both alkylating agents and azathioprine are associated wit", "tokenized_content": [2, 3939, 2447, 1954, 6588, 10647, 27932, 1935, 8111, 3, 1956, 28912, 4820, 2162, 1925, 2502, 2565, 1927, 2740, 1927, 3939, 2447, 1954, 6588, 10647, 27932, 1935, 8111, 16, 1930, 2321, 3]}, "items": [{"id": "p_3749", "content": "Leukemia, Myeloid, Acute [SEP] Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 9677, 16, 3939, 3, 11597, 7013, 1927, 9677, 25237, 1922, 3622, 6599, 16, 2877, 16, 1930, 2303, 2960, 18, 9677, 29250, 2392, 2037, 2840, 1922, 2094, 1988, 3]}]}
{"query": {"id": "q_3750", "content": "non-Hodgkin's lymphoma [SEP]  agents and azathioprine are associated with the development of non-Hodgkin's lymphoma. Cyclophosphamide therapy increases the risk of carcinoma of th", "tokenized_content": [2, 2447, 17, 17447, 11, 61, 8636, 3, 4820, 1930, 30499, 5773, 2032, 2458, 1956, 1920, 2740, 1927, 2447, 17, 17447, 11, 61, 8636, 18, 17135, 3181, 4041, 1920, 2565, 1927, 3]}, "items": [{"id": "p_3750", "content": "Lymphoma, Non-Hodgkin [SEP] Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to", "score": 1, "type": null, "tokenized_content": [2, 8636, 16, 2447, 17, 17447, 3, 2967, 1927, 43, 2210, 1927, 6558, 3861, 1927, 11751, 2960, 1988, 2129, 2037, 17447, 2573, 16, 3301, 2253, 8538, 1956, 5633, 1942, 3]}]}
{"query": {"id": "q_3751", "content": "Cyclophosphamide [SEP]  are associated with the development of non-Hodgkin's lymphoma. Cyclophosphamide therapy increases the risk of carcinoma of the bladder. There h", "tokenized_content": [2, 17135, 3, 2032, 2458, 1956, 1920, 2740, 1927, 2447, 17, 17447, 11, 61, 8636, 18, 17135, 3181, 4041, 1920, 2565, 1927, 5373, 1927, 1920, 7821, 18, 2276, 50, 3]}, "items": [{"id": "p_3751", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_3752", "content": "carcinoma of the bladder [SEP] gkin's lymphoma. Cyclophosphamide therapy increases the risk of carcinoma of the bladder. There have been several long-term studies of patients with rhe", "tokenized_content": [2, 5373, 1927, 1920, 7821, 3, 20493, 1921, 11, 61, 8636, 18, 17135, 3181, 4041, 1920, 2565, 1927, 5373, 1927, 1920, 7821, 18, 2276, 2162, 2252, 2980, 2815, 17, 2576, 2351, 3]}, "items": [{"id": "p_3752", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_3753", "content": "carcinoma [SEP] gkin's lymphoma. Cyclophosphamide therapy increases the risk of carcinoma of the bladder. There have been several long-term studies of pa", "tokenized_content": [2, 5373, 3, 20493, 1921, 11, 61, 8636, 18, 17135, 3181, 4041, 1920, 2565, 1927, 5373, 1927, 1920, 7821, 18, 2276, 2162, 2252, 2980, 2815, 17, 2576, 2351, 1927, 3838, 3]}, "items": [{"id": "p_3753", "content": "Carcinoma [SEP] A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It i", "score": 1, "type": null, "tokenized_content": [2, 5373, 3, 43, 6558, 12132, 3915, 2353, 1927, 4944, 2094, 5370, 1941, 1942, 19155, 1920, 7510, 3878, 1930, 7031, 7164, 1942, 8174, 18, 2176, 51, 3]}]}
{"query": {"id": "q_3754", "content": "cancers [SEP] ne and cyclophosphamide and the incidence of most of the common cancers is not increased. Data on the possible increased risk of malign", "tokenized_content": [2, 5717, 3, 2069, 1930, 17135, 1930, 1920, 4332, 1927, 2501, 1927, 1920, 3059, 5717, 1977, 2084, 2502, 18, 2230, 1990, 1920, 3216, 2502, 2565, 1927, 5036, 3]}, "items": [{"id": "p_3754", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3755", "content": "malignancy [SEP] ancers is not increased. Data on the possible increased risk of malignancy in rheumatoid arthritis are still being collected, and until fu", "tokenized_content": [2, 10248, 3, 10315, 2045, 1977, 2084, 2502, 18, 2230, 1990, 1920, 3216, 2502, 2565, 1927, 10248, 1922, 13053, 8884, 2032, 3974, 3301, 3651, 16, 1930, 4801, 7391, 3]}, "items": [{"id": "p_3755", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3756", "content": "hepatic injury [SEP] Patterns of hepatic injury induced by methyldopa.", "tokenized_content": [2, 6095, 4047, 3, 4147, 1927, 6095, 4047, 2719, 2007, 4963, 22389, 4302, 18, 3]}, "items": [{"id": "p_3756", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3757", "content": "methyldopa [SEP] Patterns of hepatic injury induced by methyldopa.", "tokenized_content": [2, 4963, 22389, 4302, 3, 4147, 1927, 6095, 4047, 2719, 2007, 4963, 22389, 4302, 18, 3]}, "items": [{"id": "p_3757", "content": "Methyldopa [SEP] An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an ant", "score": 1, "type": null, "tokenized_content": [2, 4963, 22389, 4302, 3, 1925, 4595, 17, 22, 13672, 7829, 1988, 2258, 2321, 4101, 1930, 5009, 7580, 2433, 2564, 18, 2496, 3065, 2535, 2485, 1977, 1966, 1925, 4942, 3]}]}
{"query": {"id": "q_3758", "content": "liver disease [SEP] Twelve patients with liver disease related to methyldopa were seen between 1967 and 1977. Illness ", "tokenized_content": [2, 3568, 2573, 3, 12367, 2132, 1956, 3568, 2573, 2712, 1942, 4963, 22389, 4302, 1985, 3945, 2192, 23962, 1930, 16824, 18, 6455, 3]}, "items": [{"id": "p_3758", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3759", "content": "methyldopa [SEP] Twelve patients with liver disease related to methyldopa were seen between 1967 and 1977. Illness occurred within 1--9 w", "tokenized_content": [2, 4963, 22389, 4302, 3, 12367, 2132, 1956, 3568, 2573, 2712, 1942, 4963, 22389, 4302, 1985, 3945, 2192, 23962, 1930, 16824, 18, 6455, 4807, 2651, 21, 17, 17, 29, 65, 3]}, "items": [{"id": "p_3759", "content": "Methyldopa [SEP] An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an ant", "score": 1, "type": null, "tokenized_content": [2, 4963, 22389, 4302, 3, 1925, 4595, 17, 22, 13672, 7829, 1988, 2258, 2321, 4101, 1930, 5009, 7580, 2433, 2564, 18, 2496, 3065, 2535, 2485, 1977, 1966, 1925, 4942, 3]}]}
{"query": {"id": "q_3760", "content": "Jaundice [SEP]  13 months, 15 months and 7 years before experiencing symptoms. Jaundice with tender hepatomegaly, usually preceded by symptoms of malai", "tokenized_content": [2, 25314, 3, 2590, 3221, 16, 2461, 3221, 1930, 27, 2739, 3119, 12511, 3601, 18, 25314, 1956, 19961, 5746, 19323, 16, 5394, 16757, 2007, 3601, 1927, 3054, 5504, 3]}, "items": [{"id": "p_3760", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_3761", "content": "hepatomegaly [SEP]  and 7 years before experiencing symptoms. Jaundice with tender hepatomegaly, usually preceded by symptoms of malaise, anorexia, nausea and ", "tokenized_content": [2, 5746, 19323, 3, 1930, 27, 2739, 3119, 12511, 3601, 18, 25314, 1956, 19961, 5746, 19323, 16, 5394, 16757, 2007, 3601, 1927, 3054, 5504, 4127, 16, 21810, 16, 13759, 1930, 3]}, "items": [{"id": "p_3761", "content": "Hepatomegaly [SEP] Enlargement of the liver.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5746, 19323, 3, 16363, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3762", "content": "anorexia [SEP] h tender hepatomegaly, usually preceded by symptoms of malaise, anorexia, nausea and vomiting, and associated with upper abdominal pain,", "tokenized_content": [2, 21810, 3, 50, 19961, 5746, 19323, 16, 5394, 16757, 2007, 3601, 1927, 3054, 5504, 4127, 16, 21810, 16, 13759, 1930, 13954, 16, 1930, 2458, 1956, 5199, 6900, 3594, 16, 3]}, "items": [{"id": "p_3762", "content": "Anorexia [SEP] The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of t", "score": 1, "type": null, "tokenized_content": [2, 21810, 3, 1920, 3630, 2014, 3257, 1927, 17990, 7936, 2007, 1925, 26433, 1942, 3959, 1930, 1920, 11752, 1942, 13619, 18, 2176, 1977, 1920, 11266, 6293, 1927, 62, 3]}]}
{"query": {"id": "q_3763", "content": "nausea [SEP] epatomegaly, usually preceded by symptoms of malaise, anorexia, nausea and vomiting, and associated with upper abdominal pain, was an ", "tokenized_content": [2, 13759, 3, 15369, 4575, 3870, 5411, 1012, 16, 5394, 16757, 2007, 3601, 1927, 3054, 5504, 4127, 16, 21810, 16, 13759, 1930, 13954, 16, 1930, 2458, 1956, 5199, 6900, 3594, 16, 3]}, "items": [{"id": "p_3763", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_3764", "content": "vomiting [SEP] , usually preceded by symptoms of malaise, anorexia, nausea and vomiting, and associated with upper abdominal pain, was an invariable fi", "tokenized_content": [2, 13954, 3, 16, 5394, 16757, 2007, 3601, 1927, 3054, 5504, 4127, 16, 21810, 16, 13759, 1930, 13954, 16, 1930, 2458, 1956, 5199, 6900, 3594, 16, 1982, 1925, 12599, 2115, 14856, 3]}, "items": [{"id": "p_3764", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_3765", "content": "abdominal pain [SEP] laise, anorexia, nausea and vomiting, and associated with upper abdominal pain, was an invariable finding in all patients. Biochemical liver f", "tokenized_content": [2, 6900, 3594, 3, 25463, 4127, 16, 21810, 16, 13759, 1930, 13954, 16, 1930, 2458, 1956, 5199, 6900, 3594, 16, 1982, 1925, 12599, 2115, 2849, 1922, 2136, 2132, 18, 6503, 3568, 3]}, "items": [{"id": "p_3765", "content": "Abdominal Pain [SEP] Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue inju", "score": 1, "type": null, "tokenized_content": [2, 6900, 3594, 3, 15826, 1927, 15335, 16, 8740, 16, 2014, 6024, 1012, 1922, 1920, 6900, 3031, 31, 4933, 2458, 1956, 3183, 4414, 16, 2960, 2831, 1032, 3]}]}
{"query": {"id": "q_3766", "content": "necrosis [SEP] ents. Biochemical liver function tests indicated hepatocellular necrosis and correlated with histopathological evidence of hepatic injur", "tokenized_content": [2, 7476, 3, 8496, 1036, 18, 6503, 3568, 2347, 4026, 3391, 12457, 7476, 1930, 4374, 1956, 11777, 3095, 1927, 6095, 3734, 3]}, "items": [{"id": "p_3766", "content": "Necrosis [SEP] The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrol", "score": 1, "type": null, "tokenized_content": [2, 7476, 3, 1920, 6598, 2585, 6966, 1922, 2094, 1988, 2032, 17600, 2037, 10137, 2453, 2115, 8209, 18, 2176, 1977, 4189, 2007, 1920, 7529, 16, 14779, 3]}]}
{"query": {"id": "q_3767", "content": "hepatic injury [SEP] ular necrosis and correlated with histopathological evidence of hepatic injury, the spectrum of which ranged from fatty change and focal hepat", "tokenized_content": [2, 6095, 4047, 3, 3570, 1933, 7476, 1930, 4374, 1956, 11777, 3095, 1927, 6095, 4047, 16, 1920, 5648, 1927, 2154, 7065, 2037, 5934, 3185, 1930, 8083, 5746, 3]}, "items": [{"id": "p_3767", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3768", "content": "fatty change [SEP] l evidence of hepatic injury, the spectrum of which ranged from fatty change and focal hepatocellular necrosis to massive hepatic necrosis. ", "tokenized_content": [2, 5934, 3185, 3, 54, 3095, 1927, 6095, 4047, 16, 1920, 5648, 1927, 2154, 7065, 2037, 5934, 3185, 1930, 8083, 12457, 7476, 1942, 12944, 6095, 7476, 18, 3]}, "items": [{"id": "p_3768", "content": "Fatty Liver [SEP] Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usua", "score": 1, "type": null, "tokenized_content": [2, 5934, 3568, 3, 4486, 8946, 1927, 1920, 6095, 19223, 2094, 3864, 1922, 43, 7463, 17, 12669, 3568, 18, 1920, 4552, 4486, 4858, 1977, 2022, 12169, 3]}]}
{"query": {"id": "q_3769", "content": "massive hepatic necrosis [SEP] h ranged from fatty change and focal hepatocellular necrosis to massive hepatic necrosis. Most patients showed moderate to severe acute hepatitis or chr", "tokenized_content": [2, 12944, 6095, 7476, 3, 50, 7065, 2037, 5934, 3185, 1930, 8083, 12457, 7476, 1942, 12944, 6095, 7476, 18, 2501, 2132, 2594, 5086, 1942, 4010, 3939, 7977, 2014, 8777, 3]}, "items": [{"id": "p_3769", "content": "Massive Hepatic Necrosis [SEP] Extensive and rapid death of parenchymal cells in the LIVER, often due to exposure to toxic materials. It is characterized by a ", "score": 1, "type": null, "tokenized_content": [2, 12944, 6095, 7476, 3, 6475, 1930, 4052, 3539, 1927, 19223, 2094, 1922, 1920, 3568, 16, 3868, 2810, 1942, 3395, 1942, 6161, 4751, 18, 2176, 1977, 4378, 2007, 43, 3]}]}
{"query": {"id": "q_3770", "content": "acute hepatitis [SEP] ssive hepatic necrosis. Most patients showed moderate to severe acute hepatitis or chronic active hepatitis with associated cholestasis. The dr", "tokenized_content": [2, 3939, 7977, 3, 23518, 1961, 6095, 7476, 18, 2501, 2132, 2594, 5086, 1942, 4010, 3939, 7977, 2014, 3724, 3500, 7977, 1956, 2458, 30086, 18, 1920, 2324, 3]}, "items": [{"id": "p_3770", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_3771", "content": "chronic active hepatitis [SEP] sis. Most patients showed moderate to severe acute hepatitis or chronic active hepatitis with associated cholestasis. The drug was withdrawn on presenta", "tokenized_content": [2, 3724, 3500, 7977, 3, 19149, 18, 2501, 2132, 2594, 5086, 1942, 4010, 3939, 7977, 2014, 3724, 3500, 7977, 1956, 2458, 30086, 18, 1920, 2838, 1982, 19540, 1990, 2481, 1019, 3]}, "items": [{"id": "p_3771", "content": "Hepatitis, Chronic [SEP] INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and ", "score": 1, "type": null, "tokenized_content": [2, 7977, 16, 3724, 3, 4531, 1927, 1920, 3568, 1956, 8234, 12457, 4047, 1958, 26, 3221, 2014, 2253, 16, 4378, 2007, 7476, 1927, 9919, 1930, 3]}]}
{"query": {"id": "q_3772", "content": "cholestasis [SEP] ere acute hepatitis or chronic active hepatitis with associated cholestasis. The drug was withdrawn on presentation to hospital in 11 patie", "tokenized_content": [2, 30086, 3, 22561, 3939, 7977, 2014, 3724, 3500, 7977, 1956, 2458, 30086, 18, 1920, 2838, 1982, 19540, 1990, 6544, 1942, 3461, 1922, 2513, 2091, 1021, 3]}, "items": [{"id": "p_3772", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3773", "content": "hepatic failure [SEP] linical improvement in 9. One patient died, having presented in hepatic failure, and another, who had been taking methyldopa for 7 years, showe", "tokenized_content": [2, 6095, 4574, 3, 8128, 2046, 4990, 1922, 29, 18, 2340, 2774, 8545, 16, 4537, 3549, 1922, 6095, 4574, 16, 1930, 3741, 16, 2746, 2430, 2252, 6303, 4963, 22389, 4302, 1958, 3]}, "items": [{"id": "p_3773", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_3774", "content": "fulminant hepatitis [SEP] f several months. The remaining patient in the series developed fulminant hepatitis when the drug was accidentally recommenced 1 year after a prior", "tokenized_content": [2, 5257, 8547, 2031, 7977, 3, 48, 2980, 3221, 18, 1920, 5719, 2774, 1922, 1920, 4696, 3530, 5257, 8547, 2031, 7977, 2469, 1920, 2838, 1982, 24842, 1954, 4347, 3877, 21, 2476, 3]}, "items": [{"id": "p_3774", "content": "Liver Failure, Acute [SEP] A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of H", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 16, 3939, 3, 43, 2386, 1927, 4052, 17, 4727, 3568, 4574, 16, 2222, 3171, 1966, 5257, 8547, 2031, 6095, 4574, 16, 4189, 2007, 4010, 3568, 4047, 2014, 12944, 3257, 1927, 50, 3]}]}
{"query": {"id": "q_3775", "content": "hepatitis [SEP] hepatic necrosis. Most patients showed moderate to severe acute hepatitis or chronic active hepatitis with associated cholestasis. The dr", "tokenized_content": [2, 7977, 3, 6095, 7476, 18, 2501, 2132, 2594, 5086, 1942, 4010, 3939, 7977, 2014, 3724, 3500, 7977, 1956, 2458, 30086, 18, 1920, 2324, 3]}, "items": [{"id": "p_3775", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3776", "content": "hepatic dysfunction [SEP] and in 2 others, the causal relationship between methyldopa and hepatic dysfunction was proved with the recurrence of hepatitis within 2 weeks of r", "tokenized_content": [2, 6095, 5273, 3, 1930, 1922, 22, 4991, 16, 1920, 9263, 3303, 2192, 4963, 22389, 4302, 1930, 6095, 5273, 1982, 9534, 1956, 1920, 6339, 1927, 7977, 2651, 22, 3625, 1927, 60, 3]}, "items": [{"id": "p_3776", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3777", "content": "paclitaxel [SEP] A phase I/II study of paclitaxel plus cisplatin as first-line therapy for head and neck cancers:", "tokenized_content": [2, 12404, 3, 43, 3193, 51, 19, 2890, 2161, 1927, 12404, 5390, 9284, 1966, 2561, 17, 2823, 3181, 1958, 4469, 1930, 7467, 5717, 30, 3]}, "items": [{"id": "p_3777", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_3778", "content": "cisplatin [SEP] A phase I/II study of paclitaxel plus cisplatin as first-line therapy for head and neck cancers: preliminary re", "tokenized_content": [2, 9284, 3, 43, 3193, 51, 19, 2890, 2161, 1927, 12404, 5390, 9284, 1966, 2561, 17, 2823, 3181, 1958, 4469, 1930, 7467, 5717, 30, 8458, 1964, 3]}, "items": [{"id": "p_3778", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3779", "content": "head and neck cancers [SEP] II study of paclitaxel plus cisplatin as first-line therapy for head and neck cancers: preliminary results.", "tokenized_content": [2, 4469, 1930, 7467, 5717, 3, 2890, 2161, 1927, 12404, 5390, 9284, 1966, 2561, 17, 2823, 3181, 1958, 4469, 1930, 7467, 5717, 30, 8458, 2274, 18, 3]}, "items": [{"id": "p_3779", "content": "Head and Neck Neoplasms [SEP] Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus.", "score": 1, "type": null, "tokenized_content": [2, 4469, 1930, 7467, 15347, 3, 3793, 2960, 3861, 2014, 2539, 11894, 2037, 1920, 9565, 7553, 1927, 1920, 3178, 31, 4726, 8568, 31, 18421, 6907, 14272, 31, 27443, 31, 1930, 6775, 16749, 18, 3]}]}
{"query": {"id": "q_3780", "content": "head and neck carcinomas [SEP] Improved outcomes among patients with head and neck carcinomas require investigations of new drugs for induction therapy. Prel", "tokenized_content": [2, 4469, 1930, 7467, 10691, 3, 4305, 3685, 2706, 2132, 1956, 4469, 1930, 7467, 10691, 4350, 7873, 1927, 2814, 4195, 1958, 4408, 3181, 18, 2097, 1024, 3]}, "items": [{"id": "p_3780", "content": "Head and Neck Neoplasms [SEP] Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus.", "score": 1, "type": null, "tokenized_content": [2, 4469, 1930, 7467, 15347, 3, 3793, 2960, 3861, 2014, 2539, 11894, 2037, 1920, 9565, 7553, 1927, 1920, 3178, 31, 4726, 8568, 31, 18421, 6907, 14272, 31, 27443, 31, 1930, 6775, 16749, 18, 3]}]}
{"query": {"id": "q_3781", "content": "paclitaxel [SEP]  of an Eastern Cooperative Oncology Group study of single-agent paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) reported a", "tokenized_content": [2, 12404, 3, 1927, 1925, 11562, 13350, 11605, 2210, 2161, 1927, 2957, 17, 5899, 12404, 12, 24411, 31, 23905, 17, 25912, 4687, 27667, 12428, 16, 5946, 30119, 16, 11421, 13, 2568, 3]}, "items": [{"id": "p_3781", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_3782", "content": "Taxol [SEP] rn Cooperative Oncology Group study of single-agent paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) reported a 37% re", "tokenized_content": [2, 24411, 3, 6364, 13350, 11605, 2210, 2161, 1927, 2957, 17, 5899, 12404, 12, 24411, 31, 23905, 17, 25912, 4687, 27667, 12428, 16, 5946, 30119, 16, 11421, 13, 2568, 43, 3191, 3]}, "items": [{"id": "p_3782", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_3783", "content": "head and neck cancer [SEP] y, Princeton, NJ) reported a 37% response rate in patients with head and neck cancer, and the paclitaxel/cisplatin combination has been used success", "tokenized_content": [2, 4469, 1930, 7467, 2539, 3, 67, 16, 5946, 30119, 16, 11421, 13, 2568, 43, 3191, 9, 2644, 2769, 1922, 2132, 1956, 4469, 1930, 7467, 2539, 16, 1930, 1920, 12404, 19, 3]}, "items": [{"id": "p_3783", "content": "Head and Neck Neoplasms [SEP] Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus.", "score": 1, "type": null, "tokenized_content": [2, 4469, 1930, 7467, 15347, 3, 3793, 2960, 3861, 2014, 2539, 11894, 2037, 1920, 9565, 7553, 1927, 1920, 3178, 31, 4726, 8568, 31, 18421, 6907, 14272, 31, 27443, 31, 1930, 6775, 16749, 18, 3]}]}
{"query": {"id": "q_3784", "content": "cisplatin [SEP]  rate in patients with head and neck cancer, and the paclitaxel/cisplatin combination has been used successfully and has significantly im", "tokenized_content": [2, 9284, 3, 2769, 1922, 2132, 1956, 4469, 1930, 7467, 2539, 16, 1930, 1920, 12404, 19, 9284, 3921, 2258, 2252, 2251, 6664, 1930, 2258, 2567, 2042, 3]}, "items": [{"id": "p_3784", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3785", "content": "ovarian cancer [SEP] ully and has significantly improved median response duration in ovarian cancer patients. We initiated a phase I/II trial to determine the resp", "tokenized_content": [2, 6751, 2539, 3, 3570, 1954, 1930, 2258, 2567, 4305, 4181, 2644, 4392, 1922, 6751, 2539, 2132, 18, 2038, 7796, 43, 3193, 51, 19, 2890, 3046, 1942, 3415, 1920, 2163, 3]}, "items": [{"id": "p_3785", "content": "Ovarian Neoplasms [SEP] Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin", "score": 1, "type": null, "tokenized_content": [2, 6751, 15347, 3, 3861, 2014, 2539, 1927, 1920, 13464, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2611, 2032, 5947, 3147, 1942, 1920, 2960, 1927, 4853, 3]}]}
{"query": {"id": "q_3786", "content": "toxicity [SEP] . We initiated a phase I/II trial to determine the response and toxicity of escalating paclitaxel doses combined with fixed-dose cisplat", "tokenized_content": [2, 5532, 3, 18, 2038, 7796, 43, 3193, 51, 19, 2890, 3046, 1942, 3415, 1920, 2644, 1930, 5532, 1927, 15279, 2287, 12404, 5312, 4252, 1956, 4779, 17, 3253, 5848, 19484, 3]}, "items": [{"id": "p_3786", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3787", "content": "head and neck carcinoma [SEP] Improved outcomes among patients with head and neck carcinomas require investigations of new drugs for induction therapy. Pre", "tokenized_content": [2, 4469, 1930, 7467, 5373, 3, 4305, 3685, 2706, 2132, 1956, 4469, 1930, 7467, 10691, 4350, 7873, 1927, 2814, 4195, 1958, 4408, 3181, 18, 2097, 3]}, "items": [{"id": "p_3787", "content": "Head and Neck Neoplasms [SEP] Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus.", "score": 1, "type": null, "tokenized_content": [2, 4469, 1930, 7467, 15347, 3, 3793, 2960, 3861, 2014, 2539, 11894, 2037, 1920, 9565, 7553, 1927, 1920, 3178, 31, 4726, 8568, 31, 18421, 6907, 14272, 31, 27443, 31, 1930, 6775, 16749, 18, 3]}]}
{"query": {"id": "q_3788", "content": "tumor [SEP] ars and good performance status have entered the trial. Primary tumor sites were oropharynx, 10 patients; hypopharynx, four; larynx, ", "tokenized_content": [2, 2798, 3, 9896, 1930, 4227, 3604, 3642, 2162, 10725, 1920, 3046, 18, 3065, 2798, 3402, 1985, 21781, 15792, 16, 2119, 2132, 31, 26497, 28476, 2304, 1039, 16, 3006, 31, 27443, 3]}, "items": [{"id": "p_3788", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3789", "content": "Alopecia [SEP] erved in patients who had achieved clinical complete responses. Alopecia, paresthesias, and arthralgias/myalgias have occurred frequentl", "tokenized_content": [2, 29640, 3, 2668, 2173, 1922, 2132, 2746, 2430, 5032, 2535, 4080, 3387, 18, 29640, 16, 2096, 29259, 1036, 16, 1930, 9273, 7317, 11966, 1036, 19, 3057, 20394, 10657, 2162, 4807, 3]}, "items": [{"id": "p_3789", "content": "Alopecia [SEP] Absence of hair from areas where it is normally present.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29640, 3, 3905, 1927, 7018, 2037, 3957, 2597, 2176, 1977, 7885, 2481, 18, 3]}]}
{"query": {"id": "q_3790", "content": "paresthesias [SEP] atients who had achieved clinical complete responses. Alopecia, paresthesias, and arthralgias/myalgias have occurred frequently, but with on", "tokenized_content": [2, 2096, 29259, 1036, 3, 2019, 6746, 2746, 2430, 5032, 2535, 4080, 3387, 18, 29640, 16, 2096, 29259, 1036, 16, 1930, 9273, 7317, 11966, 1036, 19, 3057, 20394, 10657, 2162, 4807, 3]}, "items": [{"id": "p_3790", "content": "Paresthesia [SEP] Subjective cutaneous sensations (e.g., cold, warmth, tingling, pressure, etc.) that are experienced spontaneously in the absence", "score": 1, "type": null, "tokenized_content": [2, 2096, 29259, 3, 9106, 11276, 26498, 12, 47, 18, 49, 18, 16, 6685, 16, 10142, 1963, 16, 12347, 4365, 1941, 16, 3772, 16, 8289, 18, 13, 1988, 2032, 6090, 12753, 1922, 1920, 3905, 3]}]}
{"query": {"id": "q_3791", "content": "arthralgias [SEP] hieved clinical complete responses. Alopecia, paresthesias, and arthralgias/myalgias have occurred frequently, but with one exception (a gr", "tokenized_content": [2, 9273, 7317, 11966, 1036, 3, 10220, 9488, 1919, 2535, 4080, 3387, 18, 29640, 16, 2096, 29259, 1036, 16, 1930, 9273, 7317, 11966, 1036, 19, 3057, 20394, 10657, 2162, 4807, 5467, 3]}, "items": [{"id": "p_3791", "content": "Arthralgia [SEP] Pain in the joint.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9273, 7317, 11966, 3, 3594, 1922, 1920, 6047, 18, 3]}]}
{"query": {"id": "q_3792", "content": "myalgias [SEP] cal complete responses. Alopecia, paresthesias, and arthralgias/myalgias have occurred frequently, but with one exception (a grade 3 mya", "tokenized_content": [2, 3057, 20394, 10657, 3, 2570, 4080, 3387, 18, 29640, 16, 2096, 29259, 1036, 16, 1930, 9273, 7317, 11966, 1036, 19, 3057, 20394, 10657, 2162, 4807, 5467, 16, 2308, 1956, 2340, 3]}, "items": [{"id": "p_3792", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_3793", "content": "myalgia [SEP] cal complete responses. Alopecia, paresthesias, and arthralgias/myalgias have occurred frequently, but with one exception (a grade 3 my", "tokenized_content": [2, 3057, 20394, 2126, 3, 2570, 4080, 3387, 18, 29640, 16, 2096, 29259, 1036, 16, 1930, 9273, 7317, 11966, 1036, 19, 3057, 20394, 10657, 2162, 4807, 5467, 16, 2308, 1956, 2340, 3]}, "items": [{"id": "p_3793", "content": "Myalgia [SEP] Painful sensation in the muscles.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3057, 20394, 2126, 3, 15806, 15826, 1922, 1920, 7848, 18, 3]}]}
{"query": {"id": "q_3794", "content": "Paclitaxel [SEP] de 1 or 2. No dose-limiting hematologic toxicity has been seen. Paclitaxel/cisplatin is an effective first-line regimen for locoregionally", "tokenized_content": [2, 12404, 3, 2028, 21, 2014, 22, 18, 2239, 3253, 17, 8051, 18251, 5532, 2258, 2252, 3945, 18, 12404, 19, 9284, 1977, 1925, 3655, 2561, 17, 2823, 8607, 1958, 28664, 1954, 3]}, "items": [{"id": "p_3794", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_3795", "content": "4'-0-tetrahydropyranyladriamycin [SEP] A phase I study of 4'-0-tetrahydropyranyladriamycin. Clinical pharmacology and pharmacokinetics.", "tokenized_content": [2, 24, 11, 17, 20, 17, 21196, 18425, 12804, 2015, 3027, 7898, 3, 43, 3193, 51, 2161, 1927, 24, 11, 17, 20, 17, 21196, 18425, 12804, 2015, 3027, 7898, 18, 2535, 3]}, "items": [{"id": "p_3795", "content": "pirarubicin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13774, 1933, 11156, 3, 3]}]}
{"query": {"id": "q_3796", "content": "4'-0-tetrahydropyranyladriamycin [SEP] A Phase I study of intravenous (IV) bolus 4'-0-tetrahydropyranyladriamycin (Pirarubicin) was done in 55 patients in good performance statu", "tokenized_content": [2, 24, 11, 17, 20, 17, 21196, 18425, 12804, 2015, 3027, 7898, 3, 43, 3193, 51, 2161, 1927, 7307, 12, 4370, 13, 14840, 24, 11, 17, 20, 17, 21196, 18425, 12804, 3]}, "items": [{"id": "p_3796", "content": "pirarubicin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13774, 1933, 11156, 3, 3]}]}
{"query": {"id": "q_3797", "content": "Pirarubicin [SEP] udy of intravenous (IV) bolus 4'-0-tetrahydropyranyladriamycin (Pirarubicin) was done in 55 patients in good performance status with refrac", "tokenized_content": [2, 13774, 1933, 11156, 3, 19803, 1012, 1927, 7307, 12, 4370, 13, 14840, 24, 11, 17, 20, 17, 21196, 18425, 12804, 2015, 3027, 7898, 12, 13774, 1933, 11156, 13, 1982, 5404, 3]}, "items": [{"id": "p_3797", "content": "pirarubicin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13774, 1933, 11156, 3, 3]}]}
{"query": {"id": "q_3798", "content": "tumors [SEP]  done in 55 patients in good performance status with refractory tumors. Twenty-six had minimal prior therapy (good risk), 23 had exten", "tokenized_content": [2, 3861, 3, 5404, 1922, 4288, 2132, 1922, 4227, 3604, 3642, 1956, 10923, 3861, 18, 7639, 17, 3798, 2430, 6343, 3432, 3181, 12, 4227, 2565, 13, 16, 3020, 2430, 11899, 3]}, "items": [{"id": "p_3798", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3799", "content": "hepatic dysfunction [SEP] d extensive prior therapy (poor risk), and six had renal and/or hepatic dysfunction. A total of 167 courses at doses of 15 to 70 mg/m2 were evaluab", "tokenized_content": [2, 6095, 5273, 3, 46, 6475, 3432, 3181, 12, 3930, 2565, 13, 16, 1930, 3798, 2430, 4604, 1930, 19, 2014, 6095, 5273, 18, 43, 2698, 1927, 14997, 12726, 2019, 5312, 1927, 3]}, "items": [{"id": "p_3799", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_3800", "content": "granulocytopenia [SEP] /m2. The dose-limiting toxic effect was transient noncumulative granulocytopenia. Granulocyte nadir was on day 14 (range, 4-22). Less frequent t", "tokenized_content": [2, 9015, 3107, 12903, 3, 19, 6056, 18, 1920, 3253, 17, 8051, 6161, 2495, 1982, 6809, 9341, 1989, 7797, 9015, 3107, 12903, 18, 19235, 26986, 1982, 1990, 3007, 2607, 12, 3109, 3]}, "items": [{"id": "p_3800", "content": "Agranulocytosis [SEP] A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 23171, 1928, 1944, 7349, 3, 43, 3714, 1922, 1920, 2529, 1927, 22144, 31, 12, 29929, 31, 15854, 31, 1930, 8508, 13, 18, 3]}]}
{"query": {"id": "q_3801", "content": "thrombocytopenia [SEP] s on day 14 (range, 4-22). Less frequent toxic effects included thrombocytopenia, anemia, nausea, mild alopecia, phlebitis, and mucositis. Myelo", "tokenized_content": [2, 17100, 3, 61, 1990, 3007, 2607, 12, 3109, 16, 24, 17, 2950, 13, 18, 2941, 6439, 6161, 2564, 3063, 17100, 16, 10679, 16, 13759, 16, 5809, 29640, 16, 27965, 3678, 3]}, "items": [{"id": "p_3801", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_3802", "content": "anemia [SEP] , 4-22). Less frequent toxic effects included thrombocytopenia, anemia, nausea, mild alopecia, phlebitis, and mucositis. Myelosuppress", "tokenized_content": [2, 10679, 3, 16, 24, 17, 2950, 13, 18, 2941, 6439, 6161, 2564, 3063, 17100, 16, 10679, 16, 13759, 16, 5809, 29640, 16, 27965, 3678, 16, 1930, 3422, 19976, 18, 5707, 3]}, "items": [{"id": "p_3802", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_3803", "content": "nausea [SEP]  Less frequent toxic effects included thrombocytopenia, anemia, nausea, mild alopecia, phlebitis, and mucositis. Myelosuppression was ", "tokenized_content": [2, 13759, 3, 2941, 6439, 6161, 2564, 3063, 17100, 16, 10679, 16, 13759, 16, 5809, 29640, 16, 27965, 3678, 16, 1930, 3422, 19976, 18, 5707, 1951, 3481, 3124, 1982, 3]}, "items": [{"id": "p_3803", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_3804", "content": "alopecia [SEP] t toxic effects included thrombocytopenia, anemia, nausea, mild alopecia, phlebitis, and mucositis. Myelosuppression was more in patient", "tokenized_content": [2, 29640, 3, 62, 6161, 2564, 3063, 17100, 16, 10679, 16, 13759, 16, 5809, 29640, 16, 27965, 3678, 16, 1930, 3422, 19976, 18, 5707, 1951, 3481, 3124, 1982, 2253, 1922, 2774, 3]}, "items": [{"id": "p_3804", "content": "Alopecia [SEP] Absence of hair from areas where it is normally present.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29640, 3, 3905, 1927, 7018, 2037, 3957, 2597, 2176, 1977, 7885, 2481, 18, 3]}]}
{"query": {"id": "q_3805", "content": "phlebitis [SEP] fects included thrombocytopenia, anemia, nausea, mild alopecia, phlebitis, and mucositis. Myelosuppression was more in patients with hepa", "tokenized_content": [2, 27965, 3678, 3, 16688, 1973, 3063, 17100, 16, 10679, 16, 13759, 16, 5809, 29640, 16, 27965, 3678, 16, 1930, 3422, 19976, 18, 5707, 1951, 3481, 3124, 1982, 2253, 1922, 2132, 3]}, "items": [{"id": "p_3805", "content": "Phlebitis [SEP] Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 27965, 3678, 3, 4531, 1927, 43, 7920, 16, 3868, 43, 7920, 1922, 1920, 6703, 18, 27965, 3678, 2458, 1956, 43, 2877, 15053, 1977, 6043, 12, 16379, 2102, 1952, 5443, 1937, 13, 18, 3]}]}
{"query": {"id": "q_3806", "content": "mucositis [SEP] thrombocytopenia, anemia, nausea, mild alopecia, phlebitis, and mucositis. Myelosuppression was more in patients with hepatic dysfunction", "tokenized_content": [2, 3422, 19976, 3, 17100, 16, 10679, 16, 13759, 16, 5809, 29640, 16, 27965, 3678, 16, 1930, 3422, 19976, 18, 5707, 1951, 3481, 3124, 1982, 2253, 1922, 2132, 1956, 6095, 5273, 3]}, "items": [{"id": "p_3806", "content": "Mucositis [SEP] An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vas", "score": 1, "type": null, "tokenized_content": [2, 3422, 19976, 3, 1925, 4531, 1927, 1920, 9680, 1956, 22873, 2014, 12347, 4365, 1941, 15826, 18, 2176, 1977, 4378, 2007, 10260, 1927, 1920, 10364, 8081, 16, 6350, 3]}]}
{"query": {"id": "q_3807", "content": "Myelosuppression [SEP] penia, anemia, nausea, mild alopecia, phlebitis, and mucositis. Myelosuppression was more in patients with hepatic dysfunction. Pharmacokinetic ", "tokenized_content": [2, 5707, 1951, 3481, 3124, 3, 4959, 2126, 16, 10679, 16, 13759, 16, 5809, 29640, 16, 27965, 3678, 16, 1930, 3422, 19976, 18, 5707, 1951, 3481, 3124, 1982, 2253, 1922, 2132, 3]}, "items": [{"id": "p_3807", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_3808", "content": "Adriamycinol [SEP] - 644 l/m2, and total clearance (ClT) was 204 + 39.3 l/hour/m2. Adriamycinol, doxorubicin, adriamycinone, and tetrahydropyranyladriamycinol ", "tokenized_content": [2, 25622, 7898, 1945, 3, 17, 4723, 1006, 54, 19, 6056, 16, 1930, 2698, 7802, 12, 2111, 1031, 13, 1982, 16368, 15, 3886, 18, 23, 54, 19, 6231, 19, 6056, 18, 3]}, "items": [{"id": "p_3808", "content": "adriamycinol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25622, 7898, 1945, 3, 3]}]}
{"query": {"id": "q_3809", "content": "doxorubicin [SEP] d total clearance (ClT) was 204 + 39.3 l/hour/m2. Adriamycinol, doxorubicin, adriamycinone, and tetrahydropyranyladriamycinol were the meta", "tokenized_content": [2, 12377, 3, 46, 2698, 7802, 12, 2111, 1031, 13, 1982, 16368, 15, 3886, 18, 23, 54, 19, 6231, 19, 6056, 18, 25622, 7898, 1945, 16, 12377, 16, 25622, 7898, 2290, 3]}, "items": [{"id": "p_3809", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_3810", "content": "adriamycinone [SEP] ance (ClT) was 204 + 39.3 l/hour/m2. Adriamycinol, doxorubicin, adriamycinone, and tetrahydropyranyladriamycinol were the metabolites detecte", "tokenized_content": [2, 25622, 7898, 2290, 3, 10315, 1021, 12, 2111, 1031, 13, 1982, 16368, 15, 3886, 18, 23, 54, 19, 6231, 19, 6056, 18, 25622, 7898, 1945, 16, 12377, 16, 25622, 7898, 3]}, "items": [{"id": "p_3810", "content": "adriamycin aglycone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25622, 7898, 2260, 19602, 2290, 3, 3]}]}
{"query": {"id": "q_3811", "content": "tetrahydropyranyladriamycinol [SEP] + 39.3 l/hour/m2. Adriamycinol, doxorubicin, adriamycinone, and tetrahydropyranyladriamycinol were the metabolites detected in plasma and the amount of doxor", "tokenized_content": [2, 21196, 18425, 12804, 2015, 3027, 7898, 1945, 3, 15, 3886, 18, 23, 54, 19, 6231, 19, 6056, 18, 25622, 7898, 1945, 16, 12377, 16, 25622, 7898, 2290, 16, 1930, 21196, 3]}, "items": [{"id": "p_3811", "content": "pirarubicin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13774, 1933, 11156, 3, 3]}]}
{"query": {"id": "q_3812", "content": "mesothelioma [SEP] t 24 hours was less than or equal to 10%. Activity was noted in mesothelioma, leiomyosarcoma, and basal cell carcinoma. The recommended star", "tokenized_content": [2, 25986, 3, 62, 2686, 3967, 1982, 2941, 2254, 2014, 5557, 1942, 2119, 9, 18, 2455, 1982, 5040, 1922, 25986, 16, 22917, 13063, 16, 1930, 5342, 2024, 5373, 18, 1920, 6198, 3]}, "items": [{"id": "p_3812", "content": "Mesothelioma [SEP] A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some region", "score": 1, "type": null, "tokenized_content": [2, 25986, 3, 43, 2798, 3595, 2037, 18024, 3583, 2960, 12, 28257, 16, 6483, 9280, 16, 10796, 26872, 13, 18, 2176, 5107, 1966, 4949, 14685, 1927, 2094, 16, 1956, 2673, 3031, 3]}]}
{"query": {"id": "q_3813", "content": "leiomyosarcoma [SEP]  less than or equal to 10%. Activity was noted in mesothelioma, leiomyosarcoma, and basal cell carcinoma. The recommended starting dose for Ph", "tokenized_content": [2, 22917, 13063, 3, 2941, 2254, 2014, 5557, 1942, 2119, 9, 18, 2455, 1982, 5040, 1922, 25986, 16, 22917, 13063, 16, 1930, 5342, 2024, 5373, 18, 1920, 6198, 6801, 3253, 1958, 3]}, "items": [{"id": "p_3813", "content": "Leiomyosarcoma [SEP] A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera", "score": 1, "type": null, "tokenized_content": [2, 22917, 13063, 3, 43, 13970, 3165, 3103, 10716, 2094, 1927, 6689, 3760, 18, 2876, 2176, 9671, 5110, 1922, 3793, 2960, 16, 2176, 1977, 3059, 1922, 1920, 12108, 1019, 3]}]}
{"query": {"id": "q_3814", "content": "basal cell carcinoma [SEP] to 10%. Activity was noted in mesothelioma, leiomyosarcoma, and basal cell carcinoma. The recommended starting dose for Phase II trials is 60 mg/m2 ", "tokenized_content": [2, 5342, 2024, 5373, 3, 1942, 2119, 9, 18, 2455, 1982, 5040, 1922, 25986, 16, 22917, 13063, 16, 1930, 5342, 2024, 5373, 18, 1920, 6198, 6801, 3253, 1958, 3193, 2890, 3848, 3]}, "items": [{"id": "p_3814", "content": "Carcinoma, Basal Cell [SEP] A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is d", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 5342, 2024, 3, 43, 6558, 4407, 12132, 1988, 25506, 23257, 4517, 2308, 2258, 2889, 2569, 1958, 3076, 6254, 1930, 12102, 18, 5908, 2176, 1977, 46, 3]}]}
{"query": {"id": "q_3815", "content": "gamma-hexachlorocyclohexane [SEP] Differential effects of gamma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures.", "tokenized_content": [2, 7034, 17, 7142, 22918, 20446, 23834, 2516, 3, 5611, 2564, 1927, 7034, 17, 7142, 22918, 20446, 23834, 2516, 12, 16401, 2516, 13, 1990, 24645, 17, 2719, 10060, 18, 3]}, "items": [{"id": "p_3815", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3816", "content": "lindane [SEP] Differential effects of gamma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures.", "tokenized_content": [2, 16401, 2516, 3, 5611, 2564, 1927, 7034, 17, 7142, 22918, 20446, 23834, 2516, 12, 16401, 2516, 13, 1990, 24645, 17, 2719, 10060, 18, 3]}, "items": [{"id": "p_3816", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3817", "content": "seizures [SEP] ma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures.", "tokenized_content": [2, 10060, 3, 2488, 17, 7142, 22918, 20446, 23834, 2516, 12, 16401, 2516, 13, 1990, 24645, 17, 2719, 10060, 18, 3]}, "items": [{"id": "p_3817", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3818", "content": "Gamma-hexachlorocyclohexane [SEP] Gamma-hexachlorocyclohexane (gamma-HCH), the active ingredient of the insecticide lindane, ", "tokenized_content": [2, 7034, 17, 7142, 22918, 20446, 23834, 2516, 3, 7034, 17, 7142, 22918, 20446, 23834, 2516, 12, 7034, 17, 4387, 1023, 13, 16, 1920, 3500, 24364, 1927, 1920, 21578, 16401, 2516, 3]}, "items": [{"id": "p_3818", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3819", "content": "gamma-HCH [SEP] Gamma-hexachlorocyclohexane (gamma-HCH), the active ingredient of the insecticide lindane, has been sh", "tokenized_content": [2, 7034, 17, 4387, 1023, 3, 7034, 17, 7142, 22918, 20446, 23834, 2516, 12, 7034, 17, 4387, 1023, 13, 16, 1920, 3500, 24364, 1927, 1920, 21578, 16401, 2516, 16, 2258, 2252, 3]}, "items": [{"id": "p_3819", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3820", "content": "lindane [SEP] clohexane (gamma-HCH), the active ingredient of the insecticide lindane, has been shown to decrease seizure threshold to pentylenetrazo", "tokenized_content": [2, 16401, 2516, 3, 12596, 17797, 2516, 12, 7034, 17, 4387, 1023, 13, 16, 1920, 3500, 24364, 1927, 1920, 21578, 16401, 2516, 16, 2258, 2252, 2522, 1942, 3714, 11015, 4683, 1942, 3]}, "items": [{"id": "p_3820", "content": "Lindane [SEP] An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16401, 2516, 3, 1925, 3090, 20845, 2053, 21578, 1988, 2258, 2252, 2251, 1966, 43, 5296, 16058, 2478, 3695, 1930, 43, 17529, 3821, 3349, 3695, 18, 2176, 2258, 2252, 2522, 1942, 3936, 2539, 18, 3]}]}
{"query": {"id": "q_3821", "content": "seizure [SEP] gredient of the insecticide lindane, has been shown to decrease seizure threshold to pentylenetrazol (PTZ) 3 h after exposure to gamma-", "tokenized_content": [2, 11015, 3, 2705, 7408, 1939, 1927, 1920, 21578, 16401, 2516, 16, 2258, 2252, 2522, 1942, 3714, 11015, 4683, 1942, 9412, 6752, 14278, 5524, 13642, 1024, 12, 4401, 1011, 13, 23, 3]}, "items": [{"id": "p_3821", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3822", "content": "PTZ [SEP] as been shown to decrease seizure threshold to pentylenetrazol (PTZ) 3 h after exposure to gamma-HCH and conversely increase thresh", "tokenized_content": [2, 4401, 1011, 3, 1966, 2252, 2522, 1942, 3714, 11015, 4683, 1942, 9412, 6752, 14278, 5524, 13642, 1024, 12, 4401, 1011, 13, 23, 50, 2256, 3395, 1942, 7034, 17, 4387, 1023, 3]}, "items": [{"id": "p_3822", "content": "Pentylenetetrazole [SEP] A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-comp", "score": 1, "type": null, "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 43, 11106, 5899, 1988, 10750, 2455, 1966, 43, 4101, 7580, 2433, 1930, 5481, 24252, 18, 2176, 1977, 3311, 43, 2447, 17, 2059, 3]}]}
{"query": {"id": "q_3823", "content": "seizures [SEP] e to gamma-HCH and conversely increase threshold to PTZ-induced seizures 24 h after exposure to gamma-HCH (Vohland et al. 1981). In this", "tokenized_content": [2, 10060, 3, 47, 1942, 7034, 17, 4387, 1023, 1930, 8990, 2760, 4683, 1942, 4401, 1011, 17, 2719, 10060, 2686, 50, 2256, 3395, 1942, 7034, 17, 4387, 1023, 12, 9805, 7806, 3]}, "items": [{"id": "p_3823", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3824", "content": "Seizure [SEP] hile 24 h after gamma-HCH a differential response was observed. Seizure activity due to PTZ and picrotoxin (PTX) was significantly decr", "tokenized_content": [2, 11015, 3, 18077, 1021, 2686, 50, 2256, 7034, 17, 4387, 1023, 43, 5611, 2644, 1982, 2528, 18, 11015, 2455, 2810, 1942, 4401, 1011, 1930, 7271, 6843, 9754, 12, 15609, 13, 3]}, "items": [{"id": "p_3824", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3825", "content": "picrotoxin [SEP] erential response was observed. Seizure activity due to PTZ and picrotoxin (PTX) was significantly decreased; however, seizure activity du", "tokenized_content": [2, 7271, 6843, 9754, 3, 22561, 4905, 2086, 2644, 1982, 2528, 18, 11015, 2455, 2810, 1942, 4401, 1011, 1930, 7271, 6843, 9754, 12, 15609, 13, 1982, 2567, 3261, 31, 2406, 16, 3]}, "items": [{"id": "p_3825", "content": "Picrotoxin [SEP] A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated c", "score": 1, "type": null, "tokenized_content": [2, 7271, 6843, 9754, 3, 43, 22849, 9626, 2572, 2320, 8151, 2019, 7992, 17, 43, 4086, 1930, 2842, 43, 4772, 6325, 2031, 18, 7271, 6843, 9754, 7644, 1920, 7034, 17, 29093, 2687, 17, 4128, 45, 3]}]}
{"query": {"id": "q_3826", "content": "PTX [SEP] ponse was observed. Seizure activity due to PTZ and picrotoxin (PTX) was significantly decreased; however, seizure activity due to ", "tokenized_content": [2, 15609, 3, 29557, 1021, 1982, 2528, 18, 11015, 2455, 2810, 1942, 4401, 1011, 1930, 7271, 6843, 9754, 12, 15609, 13, 1982, 2567, 3261, 31, 2406, 16, 11015, 2455, 2810, 1942, 3]}, "items": [{"id": "p_3826", "content": "Picrotoxin [SEP] A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated c", "score": 1, "type": null, "tokenized_content": [2, 7271, 6843, 9754, 3, 43, 22849, 9626, 2572, 2320, 8151, 2019, 7992, 17, 43, 4086, 1930, 2842, 43, 4772, 6325, 2031, 18, 7271, 6843, 9754, 7644, 1920, 7034, 17, 29093, 2687, 17, 4128, 45, 3]}]}
{"query": {"id": "q_3827", "content": "3-mercaptopropionic acid [SEP] ) was significantly decreased; however, seizure activity due to 3-mercaptopropionic acid (MPA), bicuculline (BCC), methyl 6,7-dimethoxy-4-ethyl-B-carbol", "tokenized_content": [2, 23, 17, 17275, 20194, 14207, 2687, 3, 13, 1982, 2567, 3261, 31, 2406, 16, 11015, 2455, 2810, 1942, 23, 17, 17275, 20194, 14207, 2687, 12, 12888, 13, 16, 8876, 1978, 3]}, "items": [{"id": "p_3827", "content": "3-Mercaptopropionic Acid [SEP] An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing co", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 17275, 20194, 14207, 2687, 3, 1925, 4106, 1927, 7627, 23922, 18, 2176, 6386, 1920, 7034, 17, 29093, 2687, 3110, 1922, 1920, 3068, 16, 6113, 7538, 2081, 3]}]}
{"query": {"id": "q_3828", "content": "MPA [SEP] sed; however, seizure activity due to 3-mercaptopropionic acid (MPA), bicuculline (BCC), methyl 6,7-dimethoxy-4-ethyl-B-carboline-3", "tokenized_content": [2, 12888, 3, 6276, 31, 2406, 16, 11015, 2455, 2810, 1942, 23, 17, 17275, 20194, 14207, 2687, 12, 12888, 13, 16, 8876, 1978, 3199, 2053, 12, 19207, 13, 16, 4963, 26, 3]}, "items": [{"id": "p_3828", "content": "3-Mercaptopropionic Acid [SEP] An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing co", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 17275, 20194, 14207, 2687, 3, 1925, 4106, 1927, 7627, 23922, 18, 2176, 6386, 1920, 7034, 17, 29093, 2687, 3110, 1922, 1920, 3068, 16, 6113, 7538, 2081, 3]}]}
{"query": {"id": "q_3829", "content": "bicuculline [SEP] owever, seizure activity due to 3-mercaptopropionic acid (MPA), bicuculline (BCC), methyl 6,7-dimethoxy-4-ethyl-B-carboline-3-carboxylate (", "tokenized_content": [2, 8876, 1978, 3199, 2053, 3, 5073, 2388, 16, 11015, 2455, 2810, 1942, 23, 17, 17275, 20194, 14207, 2687, 12, 12888, 13, 16, 8876, 1978, 3199, 2053, 12, 19207, 13, 16, 3]}, "items": [{"id": "p_3829", "content": "Bicuculline [SEP] An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors", "score": 1, "type": null, "tokenized_content": [2, 8876, 1978, 3199, 2053, 3, 1925, 4911, 11072, 8419, 29951, 2926, 2037, 9192, 2334, 1019, 18242, 3199, 6148, 1930, 2303, 4793, 18, 2176, 1977, 43, 10362, 8151, 1958, 7992, 17, 43, 4086, 3]}]}
{"query": {"id": "q_3830", "content": "BCC [SEP] re activity due to 3-mercaptopropionic acid (MPA), bicuculline (BCC), methyl 6,7-dimethoxy-4-ethyl-B-carboline-3-carboxylate (DMCM)", "tokenized_content": [2, 19207, 3, 1964, 2455, 2810, 1942, 23, 17, 17275, 20194, 14207, 2687, 12, 12888, 13, 16, 8876, 1978, 3199, 2053, 12, 19207, 13, 16, 4963, 26, 16, 27, 17, 27192, 3]}, "items": [{"id": "p_3830", "content": "Bicuculline [SEP] An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors", "score": 1, "type": null, "tokenized_content": [2, 8876, 1978, 3199, 2053, 3, 1925, 4911, 11072, 8419, 29951, 2926, 2037, 9192, 2334, 1019, 18242, 3199, 6148, 1930, 2303, 4793, 18, 2176, 1977, 43, 10362, 8151, 1958, 7992, 17, 43, 4086, 3]}]}
{"query": {"id": "q_3831", "content": "methyl 6,7-dimethoxy-4-ethyl-B-carboline-3-carboxylate [SEP] ivity due to 3-mercaptopropionic acid (MPA), bicuculline (BCC), methyl 6,7-dimethoxy-4-ethyl-B-carboline-3-carboxylate (DMCM), or strychnine (STR) was not different from control. In ", "tokenized_content": [2, 4963, 26, 16, 27, 17, 27192, 7221, 17, 24, 17, 7843, 17, 44, 17, 3697, 8419, 17, 23, 17, 20877, 3, 4370, 1999, 2810, 1942, 23, 17, 17275, 20194, 14207, 3]}, "items": [{"id": "p_3831", "content": "methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4963, 26, 16, 27, 17, 27192, 7221, 17, 24, 17, 7843, 17, 4666, 17, 3697, 8419, 17, 23, 17, 20877, 3, 3]}]}
{"query": {"id": "q_3832", "content": "DMCM [SEP]  (BCC), methyl 6,7-dimethoxy-4-ethyl-B-carboline-3-carboxylate (DMCM), or strychnine (STR) was not different from control. In vitro,", "tokenized_content": [2, 3931, 12819, 3, 12, 19207, 13, 16, 4963, 26, 16, 27, 17, 27192, 7221, 17, 24, 17, 7843, 17, 44, 17, 3697, 8419, 17, 23, 17, 20877, 12, 3931, 12819, 3]}, "items": [{"id": "p_3832", "content": "methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4963, 26, 16, 27, 17, 27192, 7221, 17, 24, 17, 7843, 17, 4666, 17, 3697, 8419, 17, 23, 17, 20877, 3, 3]}]}
{"query": {"id": "q_3833", "content": "strychnine [SEP] thyl 6,7-dimethoxy-4-ethyl-B-carboline-3-carboxylate (DMCM), or strychnine (STR) was not different from control. In vitro, gamma-HCH, pent", "tokenized_content": [2, 2114, 3204, 8635, 2912, 3, 30193, 26, 16, 27, 17, 27192, 7221, 17, 24, 17, 7843, 17, 44, 17, 3697, 8419, 17, 23, 17, 20877, 12, 3931, 12819, 13, 16, 3]}, "items": [{"id": "p_3833", "content": "Strychnine [SEP] An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsan", "score": 1, "type": null, "tokenized_content": [2, 2114, 3204, 8635, 2912, 3, 1925, 29951, 2435, 1922, 1920, 9869, 1927, 2114, 3204, 11873, 1036, 13232, 1039, 17, 13463, 6102, 18, 2176, 1977, 43, 10362, 8151, 2019, 10646, 4086, 1930, 2842, 43, 4772, 6325, 1928, 3]}]}
{"query": {"id": "q_3834", "content": "STR [SEP] ethoxy-4-ethyl-B-carboline-3-carboxylate (DMCM), or strychnine (STR) was not different from control. In vitro, gamma-HCH, pentylene", "tokenized_content": [2, 2114, 3, 3293, 7221, 17, 24, 17, 7843, 17, 44, 17, 3697, 8419, 17, 23, 17, 20877, 12, 3931, 12819, 13, 16, 2014, 2114, 3204, 8635, 2912, 12, 2114, 13, 3]}, "items": [{"id": "p_3834", "content": "Strychnine [SEP] An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsan", "score": 1, "type": null, "tokenized_content": [2, 2114, 3204, 8635, 2912, 3, 1925, 29951, 2435, 1922, 1920, 9869, 1927, 2114, 3204, 11873, 1036, 13232, 1039, 17, 13463, 6102, 18, 2176, 1977, 43, 10362, 8151, 2019, 10646, 4086, 1930, 2842, 43, 4772, 6325, 1928, 3]}]}
{"query": {"id": "q_3835", "content": "pentylenetetrazol [SEP] nine (STR) was not different from control. In vitro, gamma-HCH, pentylenetetrazol and picrotoxin were shown to inhibit 3H-TBOB binding in mouse w", "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1024, 3, 6360, 12, 2114, 13, 1982, 2084, 2413, 2037, 2285, 18, 1922, 3596, 16, 7034, 17, 4387, 1023, 16, 9412, 6752, 14278, 21193, 13642, 3]}, "items": [{"id": "p_3835", "content": "Pentylenetetrazole [SEP] A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-comp", "score": 1, "type": null, "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 43, 11106, 5899, 1988, 10750, 2455, 1966, 43, 4101, 7580, 2433, 1930, 5481, 24252, 18, 2176, 1977, 3311, 43, 2447, 17, 2059, 3]}]}
{"query": {"id": "q_3836", "content": "3H-TBOB [SEP] mma-HCH, pentylenetetrazol and picrotoxin were shown to inhibit 3H-TBOB binding in mouse whole brain, with IC50 values of 4.6, 404 and ", "tokenized_content": [2, 7648, 17, 5152, 2389, 3, 29025, 17, 4387, 1023, 16, 9412, 6752, 14278, 21193, 13642, 1024, 1930, 7271, 6843, 9754, 1985, 2522, 1942, 2875, 7648, 17, 5152, 2389, 2743, 1922, 3]}, "items": [{"id": "p_3836", "content": "tert-butylbicyclo-2-benzoate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15757, 17, 16936, 3821, 22170, 1037, 17, 22, 17, 19225, 2010, 3, 3]}]}
{"query": {"id": "q_3837", "content": "t-butyl bicyclo-orthobenzoate [SEP] ively. MPA, BCC, DMCM, and STR showed no inhibition of 3H-TBOB (t-butyl bicyclo-orthobenzoate) binding at concentrations of 100 micron. The pharmacological c", "tokenized_content": [2, 62, 17, 16936, 8876, 3143, 1037, 17, 24343, 13058, 25120, 3, 4370, 2264, 18, 12888, 16, 19207, 16, 3931, 12819, 16, 1930, 2114, 2594, 2239, 3523, 1927, 7648, 17, 5152, 3]}, "items": [{"id": "p_3837", "content": "tert-butylbicyclo-2-benzoate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15757, 17, 16936, 3821, 22170, 1037, 17, 22, 17, 19225, 2010, 3, 3]}]}
{"query": {"id": "q_3838", "content": "GABA [SEP] he decrease in seizure activity 24 h after gamma-HCH may be the GABA-A receptor-linked chloride channel.", "tokenized_content": [2, 7992, 3, 2234, 3714, 1922, 11015, 2455, 2686, 50, 2256, 7034, 17, 4387, 1023, 2278, 1998, 1920, 7992, 17, 43, 3148, 17, 4624, 9140, 4999, 18, 3]}, "items": [{"id": "p_3838", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_3839", "content": "orbital toxicity [SEP] Severe ocular and orbital toxicity after intracarotid injection of carboplatin for recurrent gliob", "tokenized_content": [2, 13536, 5532, 3, 4010, 10046, 1930, 13536, 5532, 2256, 4245, 15742, 2669, 4107, 1927, 20072, 1958, 7457, 6534, 2389, 3]}, "items": [{"id": "p_3839", "content": "Orbital Diseases [SEP] Diseases of the bony orbit and contents except the eyeball.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13536, 3902, 3, 3902, 1927, 1920, 18525, 14905, 1930, 8906, 5574, 1920, 5723, 16344, 18, 3]}]}
{"query": {"id": "q_3840", "content": "carboplatin [SEP] ere ocular and orbital toxicity after intracarotid injection of carboplatin for recurrent glioblastomas.", "tokenized_content": [2, 20072, 3, 22561, 10046, 1930, 13536, 5532, 2256, 4245, 15742, 2669, 4107, 1927, 20072, 1958, 7457, 14224, 1036, 18, 3]}, "items": [{"id": "p_3840", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_3841", "content": "glioblastomas [SEP] icity after intracarotid injection of carboplatin for recurrent glioblastomas.", "tokenized_content": [2, 14224, 1036, 3, 25272, 3145, 2256, 4245, 15742, 2669, 4107, 1927, 20072, 1958, 7457, 14224, 1036, 18, 3]}, "items": [{"id": "p_3841", "content": "Glioblastoma [SEP] A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necr", "score": 1, "type": null, "tokenized_content": [2, 14224, 3, 43, 6558, 2386, 1927, 29941, 15055, 4378, 2007, 6483, 10728, 2421, 1927, 2094, 16, 4254, 10222, 2126, 16, 2703, 20730, 6990, 2170, 16, 1930, 3296, 1005, 3]}]}
{"query": {"id": "q_3842", "content": "Glioblastoma [SEP] BACKGROUND: Glioblastoma is a malignant tumor that occurs in the cerebrum during adultho", "tokenized_content": [2, 14224, 3, 3872, 30, 14224, 1977, 43, 6558, 2798, 1988, 5110, 1922, 1920, 6626, 24277, 2409, 4160, 10647, 3]}, "items": [{"id": "p_3842", "content": "Glioblastoma [SEP] A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necr", "score": 1, "type": null, "tokenized_content": [2, 14224, 3, 43, 6558, 2386, 1927, 29941, 15055, 4378, 2007, 6483, 10728, 2421, 1927, 2094, 16, 4254, 10222, 2126, 16, 2703, 20730, 6990, 2170, 16, 1930, 3296, 1005, 3]}]}
{"query": {"id": "q_3843", "content": "malignant tumor [SEP] BACKGROUND: Glioblastoma is a malignant tumor that occurs in the cerebrum during adulthood. With current trea", "tokenized_content": [2, 6558, 2798, 3, 3872, 30, 14224, 1977, 43, 6558, 2798, 1988, 5110, 1922, 1920, 6626, 24277, 2409, 10731, 18, 1956, 3214, 2171, 1019, 3]}, "items": [{"id": "p_3843", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3844", "content": "glioblastoma [SEP] ts is limited to approximately 1 year. Therefore, patients with glioblastoma sometimes have intracarotid injection of carcinostatics added t", "tokenized_content": [2, 14224, 3, 4894, 1977, 3892, 1942, 3993, 21, 2476, 18, 2955, 16, 2132, 1956, 14224, 8929, 2162, 4245, 15742, 2669, 4107, 1927, 4381, 14882, 1036, 4057, 62, 3]}, "items": [{"id": "p_3844", "content": "Glioblastoma [SEP] A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necr", "score": 1, "type": null, "tokenized_content": [2, 14224, 3, 43, 6558, 2386, 1927, 29941, 15055, 4378, 2007, 6483, 10728, 2421, 1927, 2094, 16, 4254, 10222, 2126, 16, 2703, 20730, 6990, 2170, 16, 1930, 3296, 1005, 3]}]}
{"query": {"id": "q_3845", "content": "carboplatin [SEP] on of carcinostatics added to the treatment regimen. Generally, carboplatin is said to have milder side effects than cisplatin, whose ocula", "tokenized_content": [2, 20072, 3, 1990, 1927, 4381, 14882, 1036, 4057, 1942, 1920, 2311, 8607, 18, 4933, 16, 20072, 1977, 12029, 1942, 2162, 23273, 4159, 2564, 2254, 9284, 16, 6098, 25669, 1019, 3]}, "items": [{"id": "p_3845", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_3846", "content": "cisplatin [SEP] Generally, carboplatin is said to have milder side effects than cisplatin, whose ocular and orbital toxicity are well known. However, we ", "tokenized_content": [2, 9284, 3, 4933, 16, 20072, 1977, 12029, 1942, 2162, 23273, 4159, 2564, 2254, 9284, 16, 6098, 10046, 1930, 13536, 5532, 2032, 2486, 3171, 18, 2406, 16, 2038, 3]}, "items": [{"id": "p_3846", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3847", "content": "orbital toxicity [SEP] id to have milder side effects than cisplatin, whose ocular and orbital toxicity are well known. However, we experienced a case of severe ocular", "tokenized_content": [2, 13536, 5532, 3, 2313, 1942, 2162, 23273, 4159, 2564, 2254, 9284, 16, 6098, 10046, 1930, 13536, 5532, 2032, 2486, 3171, 18, 2406, 16, 2038, 6090, 43, 3087, 1927, 4010, 10046, 3]}, "items": [{"id": "p_3847", "content": "Orbital Diseases [SEP] Diseases of the bony orbit and contents except the eyeball.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13536, 3902, 3, 3902, 1927, 1920, 18525, 14905, 1930, 8906, 5574, 1920, 5723, 16344, 18, 3]}]}
{"query": {"id": "q_3848", "content": "glioblastomas [SEP] received an intracarotid injection of carboplatin for recurrent glioblastomas in his left temporal lobe. He complained of pain and visual dis", "tokenized_content": [2, 14224, 1036, 3, 4004, 1925, 4245, 15742, 2669, 4107, 1927, 20072, 1958, 7457, 14224, 1036, 1922, 4167, 3506, 5338, 9581, 18, 2234, 26199, 1927, 3594, 1930, 3737, 2054, 3]}, "items": [{"id": "p_3848", "content": "Glioblastoma [SEP] A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necr", "score": 1, "type": null, "tokenized_content": [2, 14224, 3, 43, 6558, 2386, 1927, 29941, 15055, 4378, 2007, 6483, 10728, 2421, 1927, 2094, 16, 4254, 10222, 2126, 16, 2703, 20730, 6990, 2170, 16, 1930, 3296, 1005, 3]}]}
{"query": {"id": "q_3849", "content": "visual disturbance in the ipsilateral eye [SEP] oblastomas in his left temporal lobe. He complained of pain and visual disturbance in the ipsilateral eye 30 h after the injection. Various ocular symptoms and findings ", "tokenized_content": [2, 3737, 12732, 1922, 1920, 13014, 5723, 3, 10287, 2197, 4956, 1922, 4167, 3506, 5338, 9581, 18, 2234, 26199, 1927, 3594, 1930, 3737, 12732, 1922, 1920, 13014, 5723, 2627, 50, 2256, 3]}, "items": [{"id": "p_3849", "content": "Vision Disorders [SEP] Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peri", "score": 1, "type": null, "tokenized_content": [2, 9266, 4414, 3, 3737, 12454, 8051, 2340, 2014, 2253, 1927, 1920, 5937, 4088, 1927, 1920, 5723, 30, 3737, 12320, 16, 6190, 7810, 16, 4677, 9266, 16, 2014, 2953, 3]}]}
{"query": {"id": "q_3850", "content": "toxicity [SEP] ve milder side effects than cisplatin, whose ocular and orbital toxicity are well known. However, we experienced a case of severe ocular", "tokenized_content": [2, 5532, 3, 3428, 23273, 4159, 2564, 2254, 9284, 16, 6098, 10046, 1930, 13536, 5532, 2032, 2486, 3171, 18, 2406, 16, 2038, 6090, 43, 3087, 1927, 4010, 10046, 3]}, "items": [{"id": "p_3850", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3851", "content": "glycerin [SEP]  treated with intravenous administration of corticosteroids and glycerin for 6 days after the injection. Although the intraocular pressu", "tokenized_content": [2, 7757, 1921, 3, 2868, 1956, 7307, 4183, 1927, 14610, 1930, 7757, 1921, 1958, 26, 3000, 2256, 1920, 4107, 18, 2876, 1920, 17258, 3477, 1032, 3]}, "items": [{"id": "p_3851", "content": "Glycerol [SEP] A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pha", "score": 1, "type": null, "tokenized_content": [2, 9244, 3, 43, 5083, 8535, 10465, 9523, 4284, 1988, 1977, 1925, 6129, 1922, 10590, 1930, 4486, 4714, 18, 2176, 1977, 2251, 1966, 43, 7596, 16, 5138, 11560, 3660, 16, 18421, 3]}]}
{"query": {"id": "q_3852", "content": "glaucoma [SEP] ular pressure elevation caused by secondary acute angle-closure glaucoma decreased and ocular pain diminished, inexorable papilledema an", "tokenized_content": [2, 12106, 3, 3570, 1933, 3772, 8644, 4189, 2007, 4067, 3939, 6524, 17, 10408, 12106, 3261, 1930, 10046, 3594, 9597, 16, 28561, 15901, 14668, 16670, 1925, 3]}, "items": [{"id": "p_3852", "content": "Glaucoma [SEP] An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the int", "score": 1, "type": null, "tokenized_content": [2, 12106, 3, 1925, 10046, 2573, 16, 6966, 1922, 3086, 4952, 16, 4537, 1966, 2496, 3065, 3779, 1925, 11976, 2014, 43, 7637, 2760, 1922, 1920, 2218, 3]}]}
{"query": {"id": "q_3853", "content": "ocular pain [SEP]  caused by secondary acute angle-closure glaucoma decreased and ocular pain diminished, inexorable papilledema and exudative retinal detach", "tokenized_content": [2, 10046, 3594, 3, 4189, 2007, 4067, 3939, 6524, 17, 10408, 12106, 3261, 1930, 10046, 3594, 9597, 16, 28561, 15901, 14668, 16670, 1930, 18787, 2178, 6943, 11762, 3]}, "items": [{"id": "p_3853", "content": "Eye Pain [SEP] A dull or sharp painful sensation associated with the outer or inner structures of the eyeball, having different causes.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5723, 3594, 3, 43, 13247, 1024, 2014, 11707, 15806, 15826, 2458, 1956, 1920, 7642, 2014, 6671, 4061, 1927, 1920, 5723, 16344, 16, 4537, 2413, 5092, 18, 3]}]}
{"query": {"id": "q_3854", "content": "papilledema [SEP] osure glaucoma decreased and ocular pain diminished, inexorable papilledema and exudative retinal detachment continued for 3 weeks. Finally", "tokenized_content": [2, 14668, 16670, 3, 3125, 2027, 12106, 3261, 1930, 10046, 3594, 9597, 16, 28561, 15901, 14668, 16670, 1930, 18787, 2178, 6943, 16293, 7583, 1958, 23, 3625, 18, 4342, 3]}, "items": [{"id": "p_3854", "content": "Papilledema [SEP] Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of", "score": 1, "type": null, "tokenized_content": [2, 14668, 16670, 3, 11438, 1927, 1920, 10109, 15598, 16, 5394, 1922, 3279, 1956, 2502, 12179, 3772, 16, 4378, 2007, 24004, 6026, 16, 2266, 29728, 1927, 3]}]}
{"query": {"id": "q_3855", "content": "retinal detachment [SEP] nd ocular pain diminished, inexorable papilledema and exudative retinal detachment continued for 3 weeks. Finally, 6 weeks later, diffuse choriore", "tokenized_content": [2, 6943, 16293, 3, 8026, 10046, 3594, 9597, 16, 28561, 15901, 14668, 16670, 1930, 18787, 2178, 6943, 16293, 7583, 1958, 23, 3625, 18, 4342, 16, 26, 3625, 3690, 16, 9435, 25952, 3]}, "items": [{"id": "p_3855", "content": "Retinal Detachment [SEP] Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonl", "score": 1, "type": null, "tokenized_content": [2, 6943, 16293, 3, 7106, 1927, 1920, 6671, 7458, 1927, 1920, 9544, 12, 5181, 9544, 13, 2037, 1920, 12905, 8081, 18, 6943, 16293, 5110, 2253, 3059, 1024, 3]}]}
{"query": {"id": "q_3856", "content": "chorioretinal atrophy [SEP] tachment continued for 3 weeks. Finally, 6 weeks later, diffuse chorioretinal atrophy with optic atrophy occurred and the vision in his left eye was ", "tokenized_content": [2, 25952, 28771, 1923, 10260, 3, 12762, 2017, 7583, 1958, 23, 3625, 18, 4342, 16, 26, 3625, 3690, 16, 9435, 25952, 28771, 1923, 10260, 1956, 10109, 10260, 4807, 1930, 1920, 9266, 3]}, "items": [{"id": "p_3856", "content": "Sveinsson Chorioretinal Atrophy [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6456, 14818, 5590, 1916, 25952, 28771, 1923, 10260, 3, 3]}]}
{"query": {"id": "q_3857", "content": "optic atrophy [SEP] eks. Finally, 6 weeks later, diffuse chorioretinal atrophy with optic atrophy occurred and the vision in his left eye was lost. CONCLUSION: W", "tokenized_content": [2, 10109, 10260, 3, 20529, 1036, 18, 4342, 16, 26, 3625, 3690, 16, 9435, 25952, 28771, 1923, 10260, 1956, 10109, 10260, 4807, 1930, 1920, 9266, 1922, 4167, 3506, 5723, 1982, 7621, 3]}, "items": [{"id": "p_3857", "content": "Optic Atrophy [SEP] Atrophy of the optic disk which may be congenital or acquired. This condition indicates a deficiency in the number of nerve fibe", "score": 1, "type": null, "tokenized_content": [2, 10109, 10260, 3, 10260, 1927, 1920, 10109, 15598, 2154, 2278, 1998, 9901, 2014, 5815, 18, 2052, 2625, 4538, 43, 6179, 1922, 1920, 2529, 1927, 5507, 3042, 1021, 3]}]}
{"query": {"id": "q_3858", "content": "ocular toxicity [SEP] on of carboplatin, we must be aware of its potentially blinding ocular toxicity. It is recommended that further studies and investigations are ", "tokenized_content": [2, 10046, 5532, 3, 1990, 1927, 20072, 16, 2038, 4902, 1998, 11207, 1927, 2496, 5063, 23691, 10046, 5532, 18, 2176, 1977, 6198, 1988, 2520, 2351, 1930, 7873, 2032, 3]}, "items": [{"id": "p_3858", "content": "Eye Diseases [SEP] Diseases affecting the eye.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5723, 3902, 3, 3902, 7359, 1920, 5723, 18, 3]}]}
{"query": {"id": "q_3859", "content": "amsacrine [SEP] Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.", "tokenized_content": [2, 16781, 27058, 3, 3193, 2890, 2161, 1927, 1920, 16781, 27058, 12980, 3371, 17, 6224, 1009, 12, 18438, 25706, 7196, 1026, 13, 1922, 2447, 17, 2858, 2024, 3614, 2539, 18, 3]}, "items": [{"id": "p_3859", "content": "Amsacrine [SEP] Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemia", "score": 1, "type": null, "tokenized_content": [2, 16781, 27058, 3, 3835, 6312, 5802, 10533, 1988, 1977, 43, 6828, 19014, 2287, 29128, 9969, 5899, 18, 2176, 1977, 3655, 1922, 1920, 2311, 1927, 3939, 8111, 3]}]}
{"query": {"id": "q_3860", "content": "CI-921 [SEP] Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.", "tokenized_content": [2, 3371, 17, 6224, 1009, 3, 3193, 2890, 2161, 1927, 1920, 16781, 27058, 12980, 3371, 17, 6224, 1009, 12, 18438, 25706, 7196, 1026, 13, 1922, 2447, 17, 2858, 2024, 3614, 2539, 3]}, "items": [{"id": "p_3860", "content": "asulacrine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1966, 5617, 29946, 2912, 3, 3]}]}
{"query": {"id": "q_3861", "content": "NSC 343499 [SEP] Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.", "tokenized_content": [2, 18438, 25706, 7196, 1026, 3, 3193, 2890, 2161, 1927, 1920, 16781, 27058, 12980, 3371, 17, 6224, 1009, 12, 18438, 25706, 7196, 1026, 13, 1922, 2447, 17, 2858, 2024, 3614, 2539, 3]}, "items": [{"id": "p_3861", "content": "asulacrine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1966, 5617, 29946, 2912, 3, 3]}]}
{"query": {"id": "q_3862", "content": "non-small cell lung cancer [SEP] Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.", "tokenized_content": [2, 2447, 17, 2858, 2024, 3614, 2539, 3, 3193, 2890, 2161, 1927, 1920, 16781, 27058, 12980, 3371, 17, 6224, 1009, 12, 18438, 25706, 7196, 1026, 13, 1922, 2447, 17, 2858, 2024, 3]}, "items": [{"id": "p_3862", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_3863", "content": "CI-921 [SEP] CI-921 (NSC 343499; 9-[[2-methoxy-4-[(methylsulphonyl)amino]phenyl]ami", "tokenized_content": [2, 3371, 17, 6224, 1009, 3, 3371, 17, 6224, 1009, 12, 18438, 25706, 7196, 1026, 31, 29, 17, 37, 37, 22, 17, 17954, 17, 24, 17, 37, 12, 4963, 20490, 13857, 3]}, "items": [{"id": "p_3863", "content": "asulacrine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1966, 5617, 29946, 2912, 3, 3]}]}
{"query": {"id": "q_3864", "content": "NSC 343499 [SEP] CI-921 (NSC 343499; 9-[[2-methoxy-4-[(methylsulphonyl)amino]phenyl]amino] -N,5-dim", "tokenized_content": [2, 18438, 25706, 7196, 1026, 3, 3371, 17, 6224, 1009, 12, 18438, 25706, 7196, 1026, 31, 29, 17, 37, 37, 22, 17, 17954, 17, 24, 17, 37, 12, 4963, 20490, 13857, 3]}, "items": [{"id": "p_3864", "content": "asulacrine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1966, 5617, 29946, 2912, 3, 3]}]}
{"query": {"id": "q_3865", "content": "9-[[2-methoxy-4-[(methylsulphonyl)amino]phenyl]amino] -N,5-dimethyl- 4-acridinecarboxamide [SEP] CI-921 (NSC 343499; 9-[[2-methoxy-4-[(methylsulphonyl)amino]phenyl]amino] -N,5-dimethyl- 4-acridinecarboxamide) is a topoisomerase II poison with high experimental antitumour", "tokenized_content": [2, 29, 17, 37, 37, 22, 17, 17954, 17, 24, 17, 37, 12, 4963, 20490, 13857, 10647, 16323, 1024, 13, 3835, 39, 7971, 39, 3835, 39, 17, 56, 16, 25, 17, 3]}, "items": [{"id": "p_3865", "content": "asulacrine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 1966, 5617, 29946, 2912, 3, 3]}]}
{"query": {"id": "q_3866", "content": "non-small cell lung cancer [SEP] s administered by 15 min infusion to 16 evaluable patients with non-small cell lung cancer (NSCLC) (7 with no prior treatment, 9 patients in relapse follo", "tokenized_content": [2, 2447, 17, 2858, 2024, 3614, 2539, 3, 61, 5254, 2007, 2461, 2360, 7386, 1942, 2641, 23626, 2132, 1956, 2447, 17, 2858, 2024, 3614, 2539, 12, 9298, 13, 12, 27, 1956, 3]}, "items": [{"id": "p_3866", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_3867", "content": "NSCLC [SEP] usion to 16 evaluable patients with non-small cell lung cancer (NSCLC) (7 with no prior treatment, 9 patients in relapse following su", "tokenized_content": [2, 9298, 3, 2022, 2001, 1942, 2641, 23626, 2132, 1956, 2447, 17, 2858, 2024, 3614, 2539, 12, 9298, 13, 12, 27, 1956, 2239, 3432, 2311, 16, 29, 2132, 1922, 8834, 2894, 3]}, "items": [{"id": "p_3867", "content": "Carcinoma, Non-Small-Cell Lung [SEP] A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENO", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 2447, 17, 2858, 17, 2024, 3614, 3, 43, 8538, 12405, 1927, 2019, 3464, 2559, 4493, 6791, 3584, 1927, 3614, 2539, 16, 2710, 10364, 2024, 5373, 31, 29639, 3]}]}
{"query": {"id": "q_3868", "content": "squamous carcinoma [SEP] of 1 (WHO), and median age of 61 years. The histology comprised squamous carcinoma (11), adenocarcinoma (1), mixed histology (2), bronchio-alveola", "tokenized_content": [2, 10364, 5373, 3, 1927, 21, 12, 2746, 13, 16, 1930, 4181, 2632, 1927, 5473, 2739, 18, 1920, 10727, 8842, 10364, 5373, 12, 2513, 13, 16, 9573, 12, 21, 13, 16, 3]}, "items": [{"id": "p_3868", "content": "Carcinoma, Squamous Cell [SEP] A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 10364, 2024, 3, 43, 5373, 3595, 2037, 9536, 10364, 4944, 2094, 18, 2176, 2278, 2222, 4704, 1922, 3402, 2597, 21808, 2014, 27923, 8081, 3]}]}
{"query": {"id": "q_3869", "content": "adenocarcinoma [SEP] e of 61 years. The histology comprised squamous carcinoma (11), adenocarcinoma (1), mixed histology (2), bronchio-alveolar carcinoma (1) and l", "tokenized_content": [2, 9573, 3, 47, 1927, 5473, 2739, 18, 1920, 10727, 8842, 10364, 5373, 12, 2513, 13, 16, 9573, 12, 21, 13, 16, 4985, 10727, 12, 22, 13, 16, 20431, 1037, 17, 3]}, "items": [{"id": "p_3869", "content": "Adenocarcinoma [SEP] A malignant epithelial tumor with a glandular organization.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9573, 3, 43, 6558, 4944, 2798, 1956, 43, 21808, 5901, 18, 3]}]}
{"query": {"id": "q_3870", "content": "bronchio-alveolar carcinoma [SEP] uamous carcinoma (11), adenocarcinoma (1), mixed histology (2), bronchio-alveolar carcinoma (1) and large cell undifferentiated carcinoma (1). Neutropenia ", "tokenized_content": [2, 20431, 1037, 17, 10526, 5373, 3, 17942, 12492, 1957, 5373, 12, 2513, 13, 16, 9573, 12, 21, 13, 16, 4985, 10727, 12, 22, 13, 16, 20431, 1037, 17, 10526, 5373, 3]}, "items": [{"id": "p_3870", "content": "Adenocarcinoma, Bronchiolo-Alveolar [SEP] A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alve", "score": 1, "type": null, "tokenized_content": [2, 9573, 16, 30149, 1037, 17, 10526, 3, 43, 5373, 6212, 1942, 1998, 3595, 2037, 8081, 1927, 4262, 30149, 1918, 16, 1922, 2154, 1920, 12847, 2960, 13957, 4231, 1920, 23405, 3]}]}
{"query": {"id": "q_3871", "content": "undifferentiated carcinoma [SEP] d histology (2), bronchio-alveolar carcinoma (1) and large cell undifferentiated carcinoma (1). Neutropenia grade greater than or equal to 3 was seen in 1", "tokenized_content": [2, 15803, 5373, 3, 46, 10727, 12, 22, 13, 16, 20431, 1037, 17, 10526, 5373, 12, 21, 13, 1930, 3103, 2024, 15803, 5373, 12, 21, 13, 18, 18005, 4927, 3430, 2254, 3]}, "items": [{"id": "p_3871", "content": "Carcinoma [SEP] A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It i", "score": 1, "type": null, "tokenized_content": [2, 5373, 3, 43, 6558, 12132, 3915, 2353, 1927, 4944, 2094, 5370, 1941, 1942, 19155, 1920, 7510, 3878, 1930, 7031, 7164, 1942, 8174, 18, 2176, 51, 3]}]}
{"query": {"id": "q_3872", "content": "Neutropenia [SEP] ar carcinoma (1) and large cell undifferentiated carcinoma (1). Neutropenia grade greater than or equal to 3 was seen in 15 patients, infec", "tokenized_content": [2, 18005, 3, 2245, 5373, 12, 21, 13, 1930, 3103, 2024, 15803, 5373, 12, 21, 13, 18, 18005, 4927, 3430, 2254, 2014, 5557, 1942, 23, 1982, 3945, 1922, 2461, 2132, 16, 3]}, "items": [{"id": "p_3872", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_3873", "content": "infections [SEP] penia grade greater than or equal to 3 was seen in 15 patients, infections with recovery in 3, and grand mal seizures in 1 patient. Grade ", "tokenized_content": [2, 5024, 3, 4959, 2126, 4927, 3430, 2254, 2014, 5557, 1942, 23, 1982, 3945, 1922, 2461, 2132, 16, 5024, 1956, 5241, 1922, 23, 16, 1930, 12038, 3054, 10060, 1922, 21, 2774, 3]}, "items": [{"id": "p_3873", "content": "Infection [SEP] Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2909, 3, 6254, 1927, 1920, 4423, 9669, 2007, 11679, 1988, 2112, 3936, 6598, 2961, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_3874", "content": "seizures [SEP] en in 15 patients, infections with recovery in 3, and grand mal seizures in 1 patient. Grade less than or equal to 2 nausea and vomiting", "tokenized_content": [2, 10060, 3, 2066, 1922, 2461, 2132, 16, 5024, 1956, 5241, 1922, 23, 16, 1930, 12038, 3054, 10060, 1922, 21, 2774, 18, 4927, 2941, 2254, 2014, 5557, 1942, 22, 13759, 1930, 3]}, "items": [{"id": "p_3874", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_3875", "content": "nausea [SEP]  grand mal seizures in 1 patient. Grade less than or equal to 2 nausea and vomiting occurred in 66% courses and phlebitis in the infus", "tokenized_content": [2, 13759, 3, 12038, 3054, 10060, 1922, 21, 2774, 18, 4927, 2941, 2254, 2014, 5557, 1942, 22, 13759, 1930, 13954, 4807, 1922, 4970, 9, 12726, 1930, 27965, 3678, 1922, 1920, 2122, 3]}, "items": [{"id": "p_3875", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_3876", "content": "vomiting [SEP] seizures in 1 patient. Grade less than or equal to 2 nausea and vomiting occurred in 66% courses and phlebitis in the infusion arm in 37", "tokenized_content": [2, 13954, 3, 10060, 1922, 21, 2774, 18, 4927, 2941, 2254, 2014, 5557, 1942, 22, 13759, 1930, 13954, 4807, 1922, 4970, 9, 12726, 1930, 27965, 3678, 1922, 1920, 7386, 6011, 1922, 3]}, "items": [{"id": "p_3876", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_3877", "content": "phlebitis [SEP] n or equal to 2 nausea and vomiting occurred in 66% courses and phlebitis in the infusion arm in 37%. 1 patient with squamous cell carcin", "tokenized_content": [2, 27965, 3678, 3, 56, 2014, 5557, 1942, 22, 13759, 1930, 13954, 4807, 1922, 4970, 9, 12726, 1930, 27965, 3678, 1922, 1920, 7386, 6011, 1922, 3191, 9, 18, 21, 2774, 1956, 3]}, "items": [{"id": "p_3877", "content": "Phlebitis [SEP] Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 27965, 3678, 3, 4531, 1927, 43, 7920, 16, 3868, 43, 7920, 1922, 1920, 6703, 18, 27965, 3678, 2458, 1956, 43, 2877, 15053, 1977, 6043, 12, 16379, 2102, 1952, 5443, 1937, 13, 18, 3]}]}
{"query": {"id": "q_3878", "content": "squamous cell carcinoma [SEP] ourses and phlebitis in the infusion arm in 37%. 1 patient with squamous cell carcinoma achieved a partial response lasting 5 months. Further testing i", "tokenized_content": [2, 10364, 2024, 5373, 3, 19520, 1918, 1930, 27965, 3678, 1922, 1920, 7386, 6011, 1922, 3191, 9, 18, 21, 2774, 1956, 10364, 2024, 5373, 5032, 43, 5740, 2644, 11671, 25, 3221, 3]}, "items": [{"id": "p_3878", "content": "Carcinoma, Squamous Cell [SEP] A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 10364, 2024, 3, 43, 5373, 3595, 2037, 9536, 10364, 4944, 2094, 18, 2176, 2278, 2222, 4704, 1922, 3402, 2597, 21808, 2014, 27923, 8081, 3]}]}
{"query": {"id": "q_3879", "content": "tumour [SEP] xamide) is a topoisomerase II poison with high experimental antitumour activity. It was administered by 15 min infusion to 16 evaluabl", "tokenized_content": [2, 6383, 3, 23447, 16408, 1021, 13, 1977, 43, 20294, 2890, 15501, 1956, 2149, 3599, 10310, 1989, 2257, 2455, 18, 2176, 1982, 5254, 2007, 2461, 2360, 7386, 1942, 2641, 2711, 18613, 3]}, "items": [{"id": "p_3879", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_3880", "content": "Alpha-lipoic acid [SEP] Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental", "tokenized_content": [2, 4595, 17, 3178, 8643, 2687, 3, 4595, 17, 3178, 8643, 2687, 10299, 4596, 4293, 1930, 18034, 1922, 3599, 3]}, "items": [{"id": "p_3880", "content": "Thioctic Acid [SEP] An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is bio", "score": 1, "type": null, "tokenized_content": [2, 15331, 2341, 1935, 2687, 3, 1925, 5843, 29860, 2687, 11925, 1007, 1956, 2288, 12585, 1036, 2577, 1988, 2176, 1977, 8929, 2222, 6043, 43, 9412, 29860, 2687, 1922, 2673, 19759, 14995, 18, 2176, 1977, 3718, 3]}]}
{"query": {"id": "q_3881", "content": "mitochondrial damage [SEP] Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.", "tokenized_content": [2, 4596, 4293, 3, 4595, 17, 3178, 8643, 2687, 10299, 4596, 4293, 1930, 18034, 1922, 3599, 5318, 13177, 18, 3]}, "items": [{"id": "p_3881", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_3882", "content": "neurotoxicity [SEP] Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.", "tokenized_content": [2, 18034, 3, 4595, 17, 3178, 8643, 2687, 10299, 4596, 4293, 1930, 18034, 1922, 3599, 5318, 13177, 18, 3]}, "items": [{"id": "p_3882", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3883", "content": "neuropathy [SEP] chondrial damage and neurotoxicity in experimental chemotherapy neuropathy.", "tokenized_content": [2, 13177, 3, 9136, 3027, 1923, 4293, 1930, 18034, 1922, 3599, 5318, 13177, 18, 3]}, "items": [{"id": "p_3883", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_3884", "content": "alpha-lipoic acid [SEP] The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, ", "tokenized_content": [2, 4595, 17, 3178, 8643, 2687, 3, 1920, 2161, 24609, 2647, 4595, 17, 3178, 8643, 2687, 1977, 14345, 3316, 5318, 2719, 18034, 16, 3]}, "items": [{"id": "p_3884", "content": "Thioctic Acid [SEP] An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is bio", "score": 1, "type": null, "tokenized_content": [2, 15331, 2341, 1935, 2687, 3, 1925, 5843, 29860, 2687, 11925, 1007, 1956, 2288, 12585, 1036, 2577, 1988, 2176, 1977, 8929, 2222, 6043, 43, 9412, 29860, 2687, 1922, 2673, 19759, 14995, 18, 2176, 1977, 3718, 3]}]}
{"query": {"id": "q_3885", "content": "neurotoxicity [SEP] pha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurode", "tokenized_content": [2, 18034, 3, 18421, 17, 3178, 8643, 2687, 1977, 14345, 3316, 5318, 2719, 18034, 16, 2647, 4596, 4293, 5705, 43, 4140, 2770, 1922, 6161, 7927, 3]}, "items": [{"id": "p_3885", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_3886", "content": "mitochondrial damage [SEP]  neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and i", "tokenized_content": [2, 4596, 4293, 3, 14345, 3316, 5318, 2719, 18034, 16, 2647, 4596, 4293, 5705, 43, 4140, 2770, 1922, 6161, 11128, 9861, 16, 1930, 51, 3]}, "items": [{"id": "p_3886", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_3887", "content": "toxic neurodegenerative cascade [SEP] neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotective effects of alpha-lipoic acid depend on ", "tokenized_content": [2, 6161, 11128, 9861, 3, 18034, 16, 2647, 4596, 4293, 5705, 43, 4140, 2770, 1922, 6161, 11128, 9861, 16, 1930, 2647, 14345, 2564, 1927, 4595, 17, 3178, 8643, 2687, 4224, 1990, 3]}, "items": [{"id": "p_3887", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_3888", "content": "peripheral neuropathy [SEP] a protection. We used an in vitro model of chemotherapy induced peripheral neuropathy that closely mimic the in vivo condition by exposing primary cu", "tokenized_content": [2, 5009, 13177, 3, 43, 6202, 18, 2038, 2251, 1925, 1922, 3596, 2322, 1927, 5318, 2719, 5009, 13177, 1988, 6538, 10223, 1920, 1922, 3597, 2625, 2007, 20651, 3065, 5480, 3]}, "items": [{"id": "p_3888", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_3889", "content": "paclitaxel [SEP] imary cultures of dorsal root ganglion (DRG) sensory neurons to paclitaxel and cisplatin, two widely used and highly effective chemotherap", "tokenized_content": [2, 12404, 3, 2042, 2141, 5054, 1927, 7193, 5904, 12516, 12, 14801, 13, 6893, 3558, 1942, 12404, 1930, 9284, 16, 2288, 5673, 2251, 1930, 3626, 3655, 12776, 2380, 2026, 3]}, "items": [{"id": "p_3889", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_3890", "content": "cisplatin [SEP] of dorsal root ganglion (DRG) sensory neurons to paclitaxel and cisplatin, two widely used and highly effective chemotherapeutic drugs. T", "tokenized_content": [2, 9284, 3, 1927, 7193, 5904, 12516, 12, 14801, 13, 6893, 3558, 1942, 12404, 1930, 9284, 16, 2288, 5673, 2251, 1930, 3626, 3655, 14124, 4195, 18, 62, 3]}, "items": [{"id": "p_3890", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_3891", "content": "axonal damage [SEP] d investigating the efficacy of alpha-lipoic acid in preventing axonal damage and apoptosis and the function and ultrastructural morphology o", "tokenized_content": [2, 10623, 4293, 3, 46, 9651, 1920, 4348, 1927, 4595, 17, 3178, 8643, 2687, 1922, 8444, 10623, 4293, 1930, 4091, 1930, 1920, 2347, 1930, 19352, 6076, 57, 3]}, "items": [{"id": "p_3891", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_3892", "content": "mitochondrial impairment [SEP] ults demonstrate that both cisplatin and paclitaxel cause early mitochondrial impairment with loss of membrane potential and induction of autophagic vac", "tokenized_content": [2, 4596, 6159, 3, 3570, 1973, 4504, 1988, 2321, 9284, 1930, 12404, 3936, 3120, 4596, 6159, 1956, 3257, 1927, 3260, 2889, 1930, 4408, 1927, 15319, 7017, 3]}, "items": [{"id": "p_3892", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_3893", "content": "Alpha-lipoic acid [SEP] rane potential and induction of autophagic vacuoles in neurons. Alpha-lipoic acid exerts neuroprotective effects against chemotherapy induced neu", "tokenized_content": [2, 4595, 17, 3178, 8643, 2687, 3, 2845, 1021, 2889, 1930, 4408, 1927, 15319, 19129, 1922, 3558, 18, 4595, 17, 3178, 8643, 2687, 14235, 14345, 2564, 3316, 5318, 2719, 2866, 3]}, "items": [{"id": "p_3893", "content": "Thioctic Acid [SEP] An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is bio", "score": 1, "type": null, "tokenized_content": [2, 15331, 2341, 1935, 2687, 3, 1925, 5843, 29860, 2687, 11925, 1007, 1956, 2288, 12585, 1036, 2577, 1988, 2176, 1977, 8929, 2222, 6043, 43, 9412, 29860, 2687, 1922, 2673, 19759, 14995, 18, 2176, 1977, 3718, 3]}]}
{"query": {"id": "q_3894", "content": "mitochondrial toxicity [SEP] herapy induced neurotoxicity in sensory neurons: it rescues the mitochondrial toxicity and induces the expression of frataxin, an essential mitochondr", "tokenized_content": [2, 4596, 5532, 3, 3656, 18644, 2719, 18034, 1922, 6893, 3558, 30, 2176, 29096, 1920, 4596, 5532, 1930, 6387, 1920, 2294, 1927, 23228, 3857, 10960, 16, 1925, 4415, 3887, 3]}, "items": [{"id": "p_3894", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_3895", "content": "peripheral nerve toxicity [SEP] gest that alpha-lipoic acid might reduce the risk of developing peripheral nerve toxicity in patients undergoing chemotherapy and encourage further confi", "tokenized_content": [2, 5009, 5507, 5532, 3, 6919, 1988, 4595, 17, 3178, 8643, 2687, 3284, 4412, 1920, 2565, 1927, 5130, 5009, 5507, 5532, 1922, 2132, 7258, 5318, 1930, 14549, 2520, 2615, 1033, 3]}, "items": [{"id": "p_3895", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_3896", "content": "stroke [SEP] Optimising stroke prevention in non-valvular atrial fibrillation.", "tokenized_content": [2, 5235, 3, 3795, 4007, 5235, 5455, 1922, 2447, 17, 25025, 9224, 13671, 18, 3]}, "items": [{"id": "p_3896", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_3897", "content": "atrial fibrillation [SEP] Optimising stroke prevention in non-valvular atrial fibrillation.", "tokenized_content": [2, 9224, 13671, 3, 3795, 4007, 5235, 5455, 1922, 2447, 17, 25025, 9224, 13671, 18, 3]}, "items": [{"id": "p_3897", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_3898", "content": "Atrial fibrillation [SEP] Atrial fibrillation is associated with substantial morbidity and mortality. Pooled ", "tokenized_content": [2, 9224, 13671, 3, 9224, 13671, 1977, 2458, 1956, 6317, 7207, 1930, 3885, 18, 7803, 3]}, "items": [{"id": "p_3898", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_3899", "content": "warfarin [SEP] comparing antithrombotic treatment with placebo have shown that warfarin reduces the risk of stroke by 62%, and that aspirin alone reduc", "tokenized_content": [2, 16170, 3, 5640, 30464, 2311, 1956, 5936, 2162, 2522, 1988, 16170, 7268, 1920, 2565, 1927, 5235, 2007, 5374, 9, 16, 1930, 1988, 12396, 4298, 4454, 3]}, "items": [{"id": "p_3899", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_3900", "content": "stroke [SEP] tment with placebo have shown that warfarin reduces the risk of stroke by 62%, and that aspirin alone reduces the risk by 22%. Overall", "tokenized_content": [2, 5235, 3, 22377, 4905, 1956, 5936, 2162, 2522, 1988, 16170, 7268, 1920, 2565, 1927, 5235, 2007, 5374, 9, 16, 1930, 1988, 12396, 4298, 7268, 1920, 2565, 2007, 2950, 9, 18, 3]}, "items": [{"id": "p_3900", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_3901", "content": "aspirin [SEP] shown that warfarin reduces the risk of stroke by 62%, and that aspirin alone reduces the risk by 22%. Overall, in high-risk patients, ", "tokenized_content": [2, 12396, 3, 2522, 1988, 16170, 7268, 1920, 2565, 1927, 5235, 2007, 5374, 9, 16, 1930, 1988, 12396, 4298, 7268, 1920, 2565, 2007, 2950, 9, 18, 3399, 16, 1922, 2149, 17, 3]}, "items": [{"id": "p_3901", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_3902", "content": "strokes [SEP] gh-risk patients, warfarin is superior to aspirin in preventing strokes, with a relative risk reduction of 36%. Ximelagatran, an oral d", "tokenized_content": [2, 21655, 3, 6101, 17, 2565, 2132, 16, 16170, 1977, 6566, 1942, 12396, 1922, 8444, 21655, 16, 1956, 43, 3338, 2565, 3378, 1927, 3480, 9, 18, 11551, 22629, 30510, 17182, 16, 3]}, "items": [{"id": "p_3902", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_3903", "content": "Ximelagatran [SEP] n in preventing strokes, with a relative risk reduction of 36%. Ximelagatran, an oral direct thrombin inhibitor, was found to be as efficien", "tokenized_content": [2, 11551, 22629, 30510, 17182, 3, 56, 1922, 8444, 21655, 16, 1956, 43, 3338, 2565, 3378, 1927, 3480, 9, 18, 11551, 22629, 30510, 17182, 16, 1925, 4726, 3083, 12388, 4106, 16, 3]}, "items": [{"id": "p_3903", "content": "ximelagatran [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11551, 22629, 30510, 17182, 3, 3]}]}
{"query": {"id": "q_3904", "content": "vitamin K [SEP] oral direct thrombin inhibitor, was found to be as efficient as vitamin K antagonist drugs in the prevention of embolic events, but has b", "tokenized_content": [2, 6111, 53, 3, 4726, 3083, 12388, 4106, 16, 1982, 2435, 1942, 1998, 1966, 5807, 1966, 6111, 53, 8151, 4195, 1922, 1920, 5455, 1927, 12494, 1935, 3916, 16, 2308, 2258, 44, 3]}, "items": [{"id": "p_3904", "content": "Vitamin K [SEP] A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phyto", "score": 1, "type": null, "tokenized_content": [2, 6111, 53, 3, 43, 4486, 15155, 1988, 1977, 3414, 1958, 2791, 2877, 23625, 18, 2980, 4952, 1927, 6111, 53, 2162, 2252, 2899, 30, 6111, 53, 21, 12, 25512, 3]}]}
{"query": {"id": "q_3905", "content": "embolic events [SEP] as efficient as vitamin K antagonist drugs in the prevention of embolic events, but has been recently withdrawn because of abnormal liver func", "tokenized_content": [2, 12494, 1935, 3916, 3, 1966, 5807, 1966, 6111, 53, 8151, 4195, 1922, 1920, 5455, 1927, 12494, 1935, 3916, 16, 2308, 2258, 2252, 3998, 19540, 2882, 1927, 4552, 3568, 2277, 1030, 3]}, "items": [{"id": "p_3905", "content": "Embolism [SEP] Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19287, 3, 7472, 1927, 43, 2877, 8072, 2007, 1925, 12494, 1957, 2154, 2112, 1998, 43, 2877, 15053, 2014, 2303, 3075, 2348, 5145, 3485, 1922, 1920, 2877, 9814, 18, 3]}]}
{"query": {"id": "q_3906", "content": "abnormal liver function [SEP] n of embolic events, but has been recently withdrawn because of abnormal liver function tests. The ACTIVE-W (Atrial Fibrillation Clopidogrel Trial with", "tokenized_content": [2, 4552, 3568, 2347, 3, 56, 1927, 12494, 1935, 3916, 16, 2308, 2258, 2252, 3998, 19540, 2882, 1927, 4552, 3568, 2347, 4026, 18, 1920, 3500, 17, 65, 12, 9224, 13671, 20473, 3]}, "items": [{"id": "p_3906", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3907", "content": "Atrial Fibrillation [SEP] thdrawn because of abnormal liver function tests. The ACTIVE-W (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Ev", "tokenized_content": [2, 9224, 13671, 3, 1913, 8049, 1022, 2882, 1927, 4552, 3568, 2347, 4026, 18, 1920, 3500, 17, 65, 12, 9224, 13671, 20473, 3046, 1956, 15049, 1918, 16726, 1958, 5455, 1927, 4541, 3]}, "items": [{"id": "p_3907", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_3908", "content": "Clopidogrel [SEP] bnormal liver function tests. The ACTIVE-W (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events) study ", "tokenized_content": [2, 20473, 3, 11006, 2620, 3568, 2347, 4026, 18, 1920, 3500, 17, 65, 12, 9224, 13671, 20473, 3046, 1956, 15049, 1918, 16726, 1958, 5455, 1927, 4541, 3916, 13, 2161, 3]}, "items": [{"id": "p_3908", "content": "clopidogrel [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 20473, 3, 3]}]}
{"query": {"id": "q_3909", "content": "Irbesartan [SEP] tests. The ACTIVE-W (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events) study has demonstrated that ", "tokenized_content": [2, 15049, 1918, 16726, 3, 4026, 18, 1920, 3500, 17, 65, 12, 9224, 13671, 20473, 3046, 1956, 15049, 1918, 16726, 1958, 5455, 1927, 4541, 3916, 13, 2161, 2258, 3161, 1988, 3]}, "items": [{"id": "p_3909", "content": "irbesartan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15049, 1918, 16726, 3, 3]}]}
{"query": {"id": "q_3910", "content": "clopidogrel [SEP] has demonstrated that warfarin is superior to platelet therapy (clopidogrel plus aspirin) in the prevention af embolic events. Idraparinux,", "tokenized_content": [2, 20473, 3, 2258, 3161, 1988, 16170, 1977, 6566, 1942, 7163, 3181, 12, 20473, 5390, 12396, 13, 1922, 1920, 5455, 2221, 12494, 1935, 3916, 18, 2313, 5524, 2453, 1921, 8640, 16, 3]}, "items": [{"id": "p_3910", "content": "clopidogrel [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 20473, 3, 3]}]}
{"query": {"id": "q_3911", "content": "Idraparinux [SEP] (clopidogrel plus aspirin) in the prevention af embolic events. Idraparinux, a Factor Xa inhibitor, is being evaluated in patients with atr", "tokenized_content": [2, 2313, 5524, 2453, 1921, 8640, 3, 12, 20473, 5390, 12396, 13, 1922, 1920, 5455, 2221, 12494, 1935, 3916, 18, 2313, 5524, 2453, 1921, 8640, 16, 43, 2991, 23447, 4106, 16, 3]}, "items": [{"id": "p_3911", "content": "idraparinux [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2313, 5524, 2453, 1921, 8640, 3, 3]}]}
{"query": {"id": "q_3912", "content": "atrial fibrillation [SEP] nux, a Factor Xa inhibitor, is being evaluated in patients with atrial fibrillation. Angiotensin-converting enzyme inhibitors and angiotensin II re", "tokenized_content": [2, 9224, 13671, 3, 13232, 1039, 16, 43, 2991, 23447, 4106, 16, 1977, 3301, 3747, 1922, 2132, 1956, 9224, 13671, 18, 10814, 17, 15025, 4113, 4472, 1930, 10814, 2890, 1964, 3]}, "items": [{"id": "p_3912", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_3913", "content": "Angiotensin [SEP] bitor, is being evaluated in patients with atrial fibrillation. Angiotensin-converting enzyme inhibitors and angiotensin II receptor-blocki", "tokenized_content": [2, 10814, 3, 11996, 1924, 16, 1977, 3301, 3747, 1922, 2132, 1956, 9224, 13671, 18, 10814, 17, 15025, 4113, 4472, 1930, 10814, 2890, 3148, 17, 3367, 1033, 3]}, "items": [{"id": "p_3913", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_3914", "content": "angiotensin II [SEP] rial fibrillation. Angiotensin-converting enzyme inhibitors and angiotensin II receptor-blocking drugs hold promise in atrial fibrillation thr", "tokenized_content": [2, 10814, 2890, 3, 27777, 1024, 13671, 18, 10814, 17, 15025, 4113, 4472, 1930, 10814, 2890, 3148, 17, 7472, 4195, 9038, 13353, 1922, 9224, 13671, 8481, 3]}, "items": [{"id": "p_3914", "content": "Angiotensin II [SEP] An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino aci", "score": 1, "type": null, "tokenized_content": [2, 10814, 2890, 3, 1925, 5843, 24010, 1988, 1977, 43, 6828, 2308, 22001, 28404, 2684, 18, 2176, 1977, 4152, 2037, 10814, 51, 2256, 1920, 6025, 1927, 2288, 3835, 2000, 1033, 3]}]}
{"query": {"id": "q_3915", "content": "cardiac remodelling [SEP] ptor-blocking drugs hold promise in atrial fibrillation through cardiac remodelling. Preliminary studies suggest that statins could interfere with ", "tokenized_content": [2, 4435, 19935, 3, 4401, 1924, 17, 7472, 4195, 9038, 13353, 1922, 9224, 13671, 2596, 4435, 19935, 18, 8458, 2351, 3220, 1988, 15511, 2578, 11827, 1956, 3]}, "items": [{"id": "p_3915", "content": "Ventricular Remodeling [SEP] The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises ex", "score": 1, "type": null, "tokenized_content": [2, 6493, 8378, 3, 1920, 12690, 1930, 4346, 2840, 1988, 1920, 4003, 21008, 4978, 16, 5394, 2894, 6497, 8358, 18, 2176, 12936, 1975, 3]}]}
{"query": {"id": "q_3916", "content": "statins [SEP] n through cardiac remodelling. Preliminary studies suggest that statins could interfere with the risk of recurrence after electrical ca", "tokenized_content": [2, 15511, 3, 56, 2596, 4435, 19935, 18, 8458, 2351, 3220, 1988, 15511, 2578, 11827, 1956, 1920, 2565, 1927, 6339, 2256, 8287, 2332, 3]}, "items": [{"id": "p_3916", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_3917", "content": "cyclosporin A [SEP] Interaction of cyclosporin A with antineoplastic agents.", "tokenized_content": [2, 17640, 1921, 43, 3, 2835, 1927, 17640, 1921, 43, 1956, 29128, 9969, 4820, 18, 3]}, "items": [{"id": "p_3917", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_3918", "content": "etoposide [SEP] A synergistic effect of etoposide and cyclosporin A was observed in a patient with acute T-lympho", "tokenized_content": [2, 18892, 3, 43, 11322, 2495, 1927, 18892, 1930, 17640, 1921, 43, 1982, 2528, 1922, 43, 2774, 1956, 3939, 62, 17, 3541, 1037, 3]}, "items": [{"id": "p_3918", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_3919", "content": "cyclosporin A [SEP] A synergistic effect of etoposide and cyclosporin A was observed in a patient with acute T-lymphocytic leukemia in ", "tokenized_content": [2, 17640, 1921, 43, 3, 43, 11322, 2495, 1927, 18892, 1930, 17640, 1921, 43, 1982, 2528, 1922, 43, 2774, 1956, 3939, 62, 17, 18921, 8111, 1922, 3]}, "items": [{"id": "p_3919", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_3920", "content": "acute T-lymphocytic leukemia [SEP] t of etoposide and cyclosporin A was observed in a patient with acute T-lymphocytic leukemia in relapse. The concomitant administration of etoposide and cyc", "tokenized_content": [2, 3939, 62, 17, 18921, 8111, 3, 62, 1927, 18892, 1930, 17640, 1921, 43, 1982, 2528, 1922, 43, 2774, 1956, 3939, 62, 17, 18921, 8111, 1922, 8834, 18, 1920, 8537, 4183, 3]}, "items": [{"id": "p_3920", "content": "Precursor T-Cell Lymphoblastic Leukemia-Lymphoma [SEP] A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvem", "score": 1, "type": null, "tokenized_content": [2, 7897, 62, 17, 2024, 24403, 8111, 17, 8636, 3, 43, 8111, 19, 8636, 2435, 28969, 1922, 3069, 1930, 4201, 4440, 1930, 4378, 25948, 1930, 15004, 8359, 8156, 1035, 3]}]}
{"query": {"id": "q_3921", "content": "leukemic infiltration [SEP] nd cyclosporin A resulted in eradication of hitherto refractory leukemic infiltration of bone marrow. Severe side effects in terms of mental confusio", "tokenized_content": [2, 17866, 8946, 3, 8026, 17640, 1921, 43, 4306, 1922, 16850, 1927, 30126, 10923, 17866, 8946, 1927, 3622, 6599, 18, 4010, 4159, 2564, 1922, 4430, 1927, 5018, 2615, 24327, 1037, 3]}, "items": [{"id": "p_3921", "content": "Leukemic Infiltration [SEP] A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukem", "score": 1, "type": null, "tokenized_content": [2, 17866, 8946, 3, 43, 11896, 3185, 1922, 8111, 1922, 2154, 17866, 2094, 6191, 2010, 3425, 7393, 2019, 2967, 3587, 1927, 1920, 2573, 18, 2136, 3584, 1927, 22823, 3]}]}
{"query": {"id": "q_3922", "content": "confusion [SEP] ltration of bone marrow. Severe side effects in terms of mental confusion and progressive hyperbilirubinemia, however, point to an enhanc", "tokenized_content": [2, 18272, 3, 15893, 1943, 1927, 3622, 6599, 18, 4010, 4159, 2564, 1922, 4430, 1927, 5018, 18272, 1930, 7529, 4194, 12039, 14560, 3847, 16, 2406, 16, 3575, 1942, 1925, 3102, 2412, 3]}, "items": [{"id": "p_3922", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_3923", "content": "hyperbilirubinemia [SEP] evere side effects in terms of mental confusion and progressive hyperbilirubinemia, however, point to an enhancement not only of antineoplastic ef", "tokenized_content": [2, 4194, 12039, 14560, 3847, 3, 4264, 1021, 4159, 2564, 1922, 4430, 1927, 5018, 18272, 1930, 7529, 4194, 12039, 14560, 3847, 16, 2406, 16, 3575, 1942, 1925, 7489, 2084, 2444, 1927, 3]}, "items": [{"id": "p_3923", "content": "Hyperbilirubinemia [SEP] A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdow", "score": 1, "type": null, "tokenized_content": [2, 4194, 12039, 14560, 3847, 3, 43, 2625, 4378, 2007, 1925, 4552, 2760, 1927, 15702, 1922, 1920, 2877, 16, 2154, 2278, 3211, 1922, 25314, 18, 15702, 16, 43, 6017, 22389, 1018, 3]}]}
{"query": {"id": "q_3924", "content": "toxicity [SEP] o an enhancement not only of antineoplastic effects but also of toxicity in normal tissues. This report demonstrates for the first time ", "tokenized_content": [2, 5532, 3, 57, 1925, 7489, 2084, 2444, 1927, 29128, 9969, 2564, 2308, 2222, 1927, 5532, 1922, 2791, 3878, 18, 2052, 3809, 7706, 1958, 1920, 2561, 2367, 3]}, "items": [{"id": "p_3924", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3925", "content": "cefonicid [SEP] The hematologic effects of cefonicid and cefazedone in the dog: a potential model of cephalosporin h", "tokenized_content": [2, 13724, 3490, 1960, 3, 1920, 18251, 2564, 1927, 13724, 3490, 1960, 1930, 13724, 3408, 1919, 2290, 1922, 1920, 6567, 30, 43, 2889, 2322, 1927, 25091, 1921, 50, 3]}, "items": [{"id": "p_3925", "content": "Cefonicid [SEP] A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition", "score": 1, "type": null, "tokenized_content": [2, 13724, 3490, 1960, 3, 43, 2812, 17, 4841, 25091, 1921, 5254, 15132, 2014, 16774, 1954, 18, 2496, 20659, 4615, 2274, 2037, 3523, 3]}]}
{"query": {"id": "q_3926", "content": "cefazedone [SEP] The hematologic effects of cefonicid and cefazedone in the dog: a potential model of cephalosporin hematotoxicity i", "tokenized_content": [2, 13724, 3408, 1919, 2290, 3, 1920, 18251, 2564, 1927, 13724, 3490, 1960, 1930, 13724, 3408, 1919, 2290, 1922, 1920, 6567, 30, 43, 2889, 2322, 1927, 25091, 1921, 5626, 11930, 51, 3]}, "items": [{"id": "p_3926", "content": "cefazedone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13724, 3408, 1919, 2290, 3, 3]}]}
{"query": {"id": "q_3927", "content": "cephalosporin [SEP] ts of cefonicid and cefazedone in the dog: a potential model of cephalosporin hematotoxicity in man.", "tokenized_content": [2, 25091, 1921, 3, 4894, 1927, 13724, 3490, 1960, 1930, 13724, 3408, 1919, 2290, 1922, 1920, 6567, 30, 43, 2889, 2322, 1927, 25091, 1921, 5626, 11930, 1922, 2323, 18, 3]}, "items": [{"id": "p_3927", "content": "Cephalosporins [SEP] A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moie", "score": 1, "type": null, "tokenized_content": [2, 25091, 2925, 3, 43, 2210, 1927, 4949, 17, 5648, 7560, 2561, 3937, 2037, 1920, 16825, 16461, 10428, 1987, 15414, 18, 2611, 5531, 1920, 4666, 17, 15294, 15295, 1021, 3]}]}
{"query": {"id": "q_3928", "content": "hematotoxicity [SEP] d and cefazedone in the dog: a potential model of cephalosporin hematotoxicity in man.", "tokenized_content": [2, 5626, 11930, 3, 46, 1930, 13724, 3408, 1919, 2290, 1922, 1920, 6567, 30, 43, 2889, 2322, 1927, 25091, 1921, 5626, 11930, 1922, 2323, 18, 3]}, "items": [{"id": "p_3928", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_3929", "content": "Cephalosporin [SEP] Cephalosporin antibiotics cause a variety of hematologic disturbances in man,", "tokenized_content": [2, 25091, 1921, 3, 25091, 1921, 7560, 3936, 43, 5386, 1927, 18251, 12654, 1922, 2323, 16, 3]}, "items": [{"id": "p_3929", "content": "Cephalosporins [SEP] A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moie", "score": 1, "type": null, "tokenized_content": [2, 25091, 2925, 3, 43, 2210, 1927, 4949, 17, 5648, 7560, 2561, 3937, 2037, 1920, 16825, 16461, 10428, 1987, 15414, 18, 2611, 5531, 1920, 4666, 17, 15294, 15295, 1021, 3]}]}
{"query": {"id": "q_3930", "content": "hematologic disturbances [SEP] Cephalosporin antibiotics cause a variety of hematologic disturbances in man, the pathogeneses and hematopathology of which remain po", "tokenized_content": [2, 18251, 12654, 3, 25091, 1921, 7560, 3936, 43, 5386, 1927, 18251, 12654, 1922, 2323, 16, 1920, 7055, 18111, 1930, 5626, 14359, 1927, 2154, 5555, 2510, 3]}, "items": [{"id": "p_3930", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_3931", "content": "blood dyscrasias [SEP]  There is a need for a well-defined animal model in which these blood dyscrasias can be studied. In four subacute toxicity studies, the intraven", "tokenized_content": [2, 2877, 3890, 2145, 6646, 1036, 3, 2276, 1977, 43, 2942, 1958, 43, 2486, 17, 3608, 4027, 2322, 1922, 2154, 2144, 2877, 3890, 2145, 6646, 1036, 2112, 1998, 3942, 18, 1922, 3]}, "items": [{"id": "p_3931", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_3932", "content": "toxicity [SEP] n which these blood dyscrasias can be studied. In four subacute toxicity studies, the intravenous administration of cefonicid or cefazed", "tokenized_content": [2, 5532, 3, 56, 2154, 2144, 2877, 3890, 2145, 6646, 1036, 2112, 1998, 3942, 18, 1922, 3006, 25440, 5532, 2351, 16, 1920, 7307, 4183, 1927, 13724, 3490, 1960, 2014, 13724, 3408, 3]}, "items": [{"id": "p_3932", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_3933", "content": "cefonicid [SEP] ur subacute toxicity studies, the intravenous administration of cefonicid or cefazedone to beagle dogs caused a dose-dependent incidence ", "tokenized_content": [2, 13724, 3490, 1960, 3, 3674, 25440, 5532, 2351, 16, 1920, 7307, 4183, 1927, 13724, 3490, 1960, 2014, 13724, 3408, 1919, 2290, 1942, 1998, 15915, 1021, 7894, 4189, 43, 3253, 17, 3]}, "items": [{"id": "p_3933", "content": "Cefonicid [SEP] A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition", "score": 1, "type": null, "tokenized_content": [2, 13724, 3490, 1960, 3, 43, 2812, 17, 4841, 25091, 1921, 5254, 15132, 2014, 16774, 1954, 18, 2496, 20659, 4615, 2274, 2037, 3523, 3]}]}
{"query": {"id": "q_3934", "content": "cefazedone [SEP] oxicity studies, the intravenous administration of cefonicid or cefazedone to beagle dogs caused a dose-dependent incidence of anemia, neu", "tokenized_content": [2, 13724, 3408, 1919, 2290, 3, 2833, 3610, 2351, 16, 1920, 7307, 4183, 1927, 13724, 3490, 1960, 2014, 13724, 3408, 1919, 2290, 1942, 1998, 15915, 1021, 7894, 4189, 43, 3253, 17, 3]}, "items": [{"id": "p_3934", "content": "cefazedone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 13724, 3408, 1919, 2290, 3, 3]}]}
{"query": {"id": "q_3935", "content": "anemia [SEP]  cefazedone to beagle dogs caused a dose-dependent incidence of anemia, neutropenia, and thrombocytopenia after 1-3 months of treatmen", "tokenized_content": [2, 10679, 3, 13724, 3408, 1919, 2290, 1942, 1998, 15915, 1021, 7894, 4189, 43, 3253, 17, 3100, 4332, 1927, 10679, 16, 18005, 16, 1930, 17100, 2256, 21, 17, 23, 3221, 1927, 3]}, "items": [{"id": "p_3935", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_3936", "content": "neutropenia [SEP] one to beagle dogs caused a dose-dependent incidence of anemia, neutropenia, and thrombocytopenia after 1-3 months of treatment. A nonregen", "tokenized_content": [2, 18005, 3, 2340, 1942, 1998, 15915, 1021, 7894, 4189, 43, 3253, 17, 3100, 4332, 1927, 10679, 16, 18005, 16, 1930, 17100, 2256, 21, 17, 23, 3221, 1927, 2311, 18, 43, 3]}, "items": [{"id": "p_3936", "content": "Neutropenia [SEP] A decrease in the number of NEUTROPHILS found in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18005, 3, 43, 3714, 1922, 1920, 2529, 1927, 8508, 2435, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_3937", "content": "thrombocytopenia [SEP] s caused a dose-dependent incidence of anemia, neutropenia, and thrombocytopenia after 1-3 months of treatment. A nonregenerative anemia was the", "tokenized_content": [2, 17100, 3, 61, 4189, 43, 3253, 17, 3100, 4332, 1927, 10679, 16, 18005, 16, 1930, 17100, 2256, 21, 17, 23, 3221, 1927, 2311, 18, 43, 28309, 14687, 5524, 2185, 10679, 3]}, "items": [{"id": "p_3937", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_3938", "content": "cytopenias [SEP] ment. A nonregenerative anemia was the most compromising of the cytopenias and occurred in approximately 50% of dogs receiving 400-500 mg/", "tokenized_content": [2, 22953, 17125, 10657, 3, 11567, 18, 43, 28309, 14687, 5524, 2185, 10679, 1982, 1920, 2501, 24395, 1927, 1920, 22953, 17125, 10657, 1930, 4807, 1922, 3993, 2761, 9, 1927, 7894, 5962, 3]}, "items": [{"id": "p_3938", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_3939", "content": "cephalosporin [SEP] d platelets (hours to a few days). Upon rechallenge with either cephalosporin, the hematologic syndrome was reproduced in most dogs tested; c", "tokenized_content": [2, 25091, 1921, 3, 46, 10097, 12, 3967, 1942, 43, 3855, 3000, 13, 18, 4073, 27317, 2214, 26464, 1956, 3108, 25091, 1921, 16, 1920, 18251, 4741, 1982, 16281, 1922, 2501, 7894, 3]}, "items": [{"id": "p_3939", "content": "Cephalosporins [SEP] A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moie", "score": 1, "type": null, "tokenized_content": [2, 25091, 2925, 3, 43, 2210, 1927, 4949, 17, 5648, 7560, 2561, 3937, 2037, 1920, 16825, 16461, 10428, 1987, 15414, 18, 2611, 5531, 1920, 4666, 17, 15294, 15295, 1021, 3]}]}
{"query": {"id": "q_3940", "content": "hematologic syndrome [SEP] to a few days). Upon rechallenge with either cephalosporin, the hematologic syndrome was reproduced in most dogs tested; cefonicid (but not cefazedo", "tokenized_content": [2, 18251, 4741, 3, 1942, 43, 3855, 3000, 13, 18, 4073, 27317, 2214, 26464, 1956, 3108, 25091, 1921, 16, 1920, 18251, 4741, 1982, 16281, 1922, 2501, 7894, 3620, 31, 13724, 3490, 3]}, "items": [{"id": "p_3940", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_3941", "content": "hemolytic [SEP] e in red cell mass parameters of affected dogs, suggests that a hemolytic component complicated the red cell production problem and that ", "tokenized_content": [2, 21515, 3, 47, 1922, 2312, 2024, 3411, 3673, 1927, 4218, 7894, 16, 4015, 1988, 43, 21515, 4594, 9881, 1920, 2312, 2024, 3372, 4915, 1930, 1988, 3]}, "items": [{"id": "p_3941", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_3942", "content": "cytopenia [SEP] d a dose-dependent incidence of anemia, neutropenia, and thrombocytopenia after 1-3 months of treatment. A nonregenerative anemia was the", "tokenized_content": [2, 22953, 17125, 2126, 3, 46, 43, 3253, 17, 3100, 4332, 1927, 10679, 16, 18005, 16, 1930, 17100, 2256, 21, 17, 23, 3221, 1927, 2311, 18, 43, 28309, 14687, 5524, 2185, 3]}, "items": [{"id": "p_3942", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_3943", "content": "hematotoxicity [SEP] ion of high doses of cefonicid or cefazedone to dogs can induce hematotoxicity similar to the cephalosporin-induced blood dyscrasias described", "tokenized_content": [2, 5626, 11930, 3, 4755, 1927, 2149, 5312, 1927, 13724, 3490, 1960, 2014, 13724, 3408, 1919, 2290, 1942, 7894, 2112, 4769, 5626, 11930, 2551, 1942, 1920, 25091, 1921, 17, 2719, 2877, 3]}, "items": [{"id": "p_3943", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_3944", "content": "pyridoxine [SEP] A pyridoxine-dependent behavioral disorder unmasked by isoniazid.", "tokenized_content": [2, 24828, 9754, 1021, 3, 43, 24828, 9754, 1021, 17, 3100, 5343, 4770, 30370, 1919, 2007, 28383, 18, 3]}, "items": [{"id": "p_3944", "content": "Pyridoxine [SEP] The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, n", "score": 1, "type": null, "tokenized_content": [2, 24828, 9754, 1021, 3, 1920, 24, 17, 8570, 2386, 1927, 6111, 44, 26, 2154, 1977, 9076, 1942, 24828, 23859, 5413, 2154, 1977, 43, 22051, 1958, 4271, 1927, 3835, 4576, 16, 56, 3]}]}
{"query": {"id": "q_3945", "content": "behavioral disorder [SEP] A pyridoxine-dependent behavioral disorder unmasked by isoniazid.", "tokenized_content": [2, 5343, 4770, 3, 43, 24828, 9754, 1021, 17, 3100, 5343, 4770, 30370, 1919, 2007, 28383, 18, 3]}, "items": [{"id": "p_3945", "content": "Child Behavior Disorders [SEP] Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depr", "score": 1, "type": null, "tokenized_content": [2, 2748, 3379, 4414, 3, 12654, 3311, 1942, 1998, 6598, 2454, 1990, 2632, 1930, 3587, 24286, 16, 47, 18, 49, 18, 16, 7569, 12654, 1930, 7381, 2223, 12013, 9061, 3]}]}
{"query": {"id": "q_3946", "content": "isoniazid [SEP] A pyridoxine-dependent behavioral disorder unmasked by isoniazid.", "tokenized_content": [2, 28383, 3, 43, 24828, 9754, 1021, 17, 3100, 5343, 4770, 30370, 1919, 2007, 28383, 18, 3]}, "items": [{"id": "p_3946", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_3947", "content": "behavioral deterioration [SEP] A 3-year-old girl had behavioral deterioration, with hyperkinesis, irritability, and sleeping difficulties aft", "tokenized_content": [2, 5343, 13318, 3, 43, 23, 17, 2476, 17, 4156, 21676, 2430, 5343, 13318, 16, 1956, 4194, 23786, 1937, 16, 29534, 16, 1930, 21047, 9097, 2221, 1031, 3]}, "items": [{"id": "p_3947", "content": "Child Behavior Disorders [SEP] Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depr", "score": 1, "type": null, "tokenized_content": [2, 2748, 3379, 4414, 3, 12654, 3311, 1942, 1998, 6598, 2454, 1990, 2632, 1930, 3587, 24286, 16, 47, 18, 49, 18, 16, 7569, 12654, 1930, 7381, 2223, 12013, 9061, 3]}]}
{"query": {"id": "q_3948", "content": "hyperkinesis [SEP] A 3-year-old girl had behavioral deterioration, with hyperkinesis, irritability, and sleeping difficulties after the therapeutic ", "tokenized_content": [2, 4194, 23786, 1937, 3, 43, 23, 17, 2476, 17, 4156, 21676, 2430, 5343, 13318, 16, 1956, 4194, 23786, 1937, 16, 29534, 16, 1930, 21047, 9097, 2256, 1920, 4272, 3]}, "items": [{"id": "p_3948", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_3949", "content": "irritability [SEP] -year-old girl had behavioral deterioration, with hyperkinesis, irritability, and sleeping difficulties after the therapeutic administration", "tokenized_content": [2, 29534, 3, 17, 2476, 17, 4156, 21676, 2430, 5343, 13318, 16, 1956, 4194, 23786, 1937, 16, 29534, 16, 1930, 21047, 9097, 2256, 1920, 4272, 4183, 3]}, "items": [{"id": "p_3949", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_3950", "content": "sleeping difficulties [SEP]  behavioral deterioration, with hyperkinesis, irritability, and sleeping difficulties after the therapeutic administration of isoniazid. The administ", "tokenized_content": [2, 21047, 9097, 3, 5343, 13318, 16, 1956, 4194, 23786, 1937, 16, 29534, 16, 1930, 21047, 9097, 2256, 1920, 4272, 4183, 1927, 28383, 18, 1920, 3318, 2184, 3]}, "items": [{"id": "p_3950", "content": "Sleep Disorders [SEP] Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major c", "score": 1, "type": null, "tokenized_content": [2, 5006, 4414, 3, 2961, 4378, 2007, 12654, 1927, 10616, 5006, 4147, 2014, 5888, 18, 5006, 4414, 2278, 1998, 5831, 2460, 2559, 3044, 45, 3]}]}
{"query": {"id": "q_3951", "content": "isoniazid [SEP] d sleeping difficulties after the therapeutic administration of isoniazid. The administration of pharmacologic doses of pyridoxine hydroc", "tokenized_content": [2, 28383, 3, 46, 21047, 9097, 2256, 1920, 4272, 4183, 1927, 28383, 18, 1920, 4183, 1927, 17225, 5312, 1927, 24828, 9754, 1021, 13107, 3]}, "items": [{"id": "p_3951", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_3952", "content": "pyridoxine hydrochloride [SEP] tion of isoniazid. The administration of pharmacologic doses of pyridoxine hydrochloride led to a disappearance of symptoms. After discontinuing isoniaz", "tokenized_content": [2, 24828, 9754, 1021, 16675, 3, 8685, 1916, 1927, 28383, 18, 1920, 4183, 1927, 17225, 5312, 1927, 24828, 9754, 1021, 16675, 4866, 1942, 43, 18271, 1927, 3601, 18, 2256, 9035, 13768, 3]}, "items": [{"id": "p_3952", "content": "Pyridoxine [SEP] The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, n", "score": 1, "type": null, "tokenized_content": [2, 24828, 9754, 1021, 3, 1920, 24, 17, 8570, 2386, 1927, 6111, 44, 26, 2154, 1977, 9076, 1942, 24828, 23859, 5413, 2154, 1977, 43, 22051, 1958, 4271, 1927, 3835, 4576, 16, 56, 3]}]}
{"query": {"id": "q_3953", "content": "pyridoxine [SEP] tion of isoniazid. The administration of pharmacologic doses of pyridoxine hydrochloride led to a disappearance of symptoms. After discont", "tokenized_content": [2, 24828, 9754, 1021, 3, 8685, 1916, 1927, 28383, 18, 1920, 4183, 1927, 17225, 5312, 1927, 24828, 9754, 1021, 16675, 4866, 1942, 43, 18271, 1927, 3601, 18, 2256, 2863, 4202, 3]}, "items": [{"id": "p_3953", "content": "Pyridoxine [SEP] The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, n", "score": 1, "type": null, "tokenized_content": [2, 24828, 9754, 1021, 3, 1920, 24, 17, 8570, 2386, 1927, 6111, 44, 26, 2154, 1977, 9076, 1942, 24828, 23859, 5413, 2154, 1977, 43, 22051, 1958, 4271, 1927, 3835, 4576, 16, 56, 3]}]}
{"query": {"id": "q_3954", "content": "niacinamide [SEP] that was controlled by pyridoxine. A placebo had no effect, but niacinamide was as effective as pyridoxine. Periodic withdrawal of pyridoxi", "tokenized_content": [2, 21946, 3665, 5482, 3, 1988, 1982, 4642, 2007, 24828, 9754, 1021, 18, 43, 5936, 2430, 2239, 2495, 16, 2308, 21946, 3665, 5482, 1982, 1966, 3655, 1966, 24828, 9754, 1021, 18, 3]}, "items": [{"id": "p_3954", "content": "Niacinamide [SEP] An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure ", "score": 1, "type": null, "tokenized_content": [2, 21946, 3665, 5482, 3, 1925, 2715, 3547, 7295, 1966, 43, 4594, 1927, 1920, 22051, 6577, 18, 2496, 3065, 4550, 1977, 1922, 1920, 5455, 1930, 19, 2014, 12338, 3]}]}
{"query": {"id": "q_3955", "content": "pyridoxal [SEP] ne was associated with return of the hyperkinesis. The level of pyridoxal in the blood was normal during the periods of relapse. Metaboli", "tokenized_content": [2, 24828, 23859, 3, 2069, 1982, 2458, 1956, 7215, 1927, 1920, 4194, 23786, 1937, 18, 1920, 2237, 1927, 24828, 23859, 1922, 1920, 2877, 1982, 2791, 2409, 1920, 6696, 1927, 8834, 18, 3]}, "items": [{"id": "p_3955", "content": "Pyridoxal [SEP] The 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino a", "score": 1, "type": null, "tokenized_content": [2, 24828, 23859, 3, 1920, 24, 17, 15750, 8790, 2386, 1927, 6111, 44, 26, 2154, 1977, 9076, 1942, 24828, 23859, 5413, 2154, 1977, 43, 22051, 1958, 4271, 1927, 3835, 43, 3]}]}
{"query": {"id": "q_3956", "content": "kynurenine [SEP]  periods of relapse. Metabolic studies suggested a block in the kynurenine pathway of tryptophan metabolism. The patient has been followed", "tokenized_content": [2, 23523, 24684, 2053, 3, 6696, 1927, 8834, 18, 4487, 2351, 3978, 43, 3367, 1922, 1920, 23523, 24684, 2053, 3374, 1927, 13489, 4714, 18, 1920, 2774, 2258, 2252, 3489, 3]}, "items": [{"id": "p_3956", "content": "Kynurenine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23523, 24684, 2053, 3, 3]}]}
{"query": {"id": "q_3957", "content": "tryptophan [SEP] etabolic studies suggested a block in the kynurenine pathway of tryptophan metabolism. The patient has been followed for six years and has", "tokenized_content": [2, 13489, 3, 20634, 4627, 3742, 2351, 3978, 43, 3367, 1922, 1920, 23523, 24684, 2053, 3374, 1927, 13489, 4714, 18, 1920, 2774, 2258, 2252, 3489, 1958, 3798, 2739, 1930, 2258, 3]}, "items": [{"id": "p_3957", "content": "Tryptophan [SEP] An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of ", "score": 1, "type": null, "tokenized_content": [2, 13489, 3, 1925, 4415, 3835, 2687, 1988, 1977, 4680, 1958, 2791, 2905, 1922, 5969, 1930, 1958, 6634, 6766, 1922, 4440, 18, 2176, 1977, 43, 7897, 1927, 3]}]}
{"query": {"id": "q_3958", "content": "dopamine [SEP] A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacolog", "tokenized_content": [2, 7964, 3, 43, 5328, 7964, 16603, 3148, 8151, 16, 5214, 1019, 6924, 5127, 30, 43, 10311, 15692, 14642, 2167, 3]}, "items": [{"id": "p_3958", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3959", "content": "NRA0160 [SEP] A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacological profile.", "tokenized_content": [2, 5214, 1019, 6924, 5127, 3, 43, 5328, 7964, 16603, 3148, 8151, 16, 5214, 1019, 6924, 5127, 30, 43, 10311, 15692, 14642, 2477, 5174, 18, 3]}, "items": [{"id": "p_3959", "content": "NRA 0160 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5214, 1019, 17300, 1008, 3, 3]}]}
{"query": {"id": "q_3960", "content": "NRA0160 [SEP] NRA0160, 5 - [2- ( 4- ( 3 - fluorobenzylidene) piperidin-1-yl) ethyl] -", "tokenized_content": [2, 5214, 1019, 6924, 5127, 3, 5214, 1019, 6924, 5127, 16, 25, 17, 37, 22, 17, 12, 24, 17, 12, 23, 17, 16191, 13058, 2199, 18574, 13, 16057, 7650, 17, 21, 3]}, "items": [{"id": "p_3960", "content": "NRA 0160 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5214, 1019, 17300, 1008, 3, 3]}]}
{"query": {"id": "q_3961", "content": "5 - [2- ( 4- ( 3 - fluorobenzylidene) piperidin-1-yl) ethyl] - 4 -(4-fluorophenyl) thiazole-2-carboxamide [SEP] NRA0160, 5 - [2- ( 4- ( 3 - fluorobenzylidene) piperidin-1-yl) ethyl] - 4 -(4-fluorophenyl) thiazole-2-carboxamide, has a high affinity for human cloned dopamine D4.2, D4.4 and D", "tokenized_content": [2, 25, 17, 37, 22, 17, 12, 24, 17, 12, 23, 17, 16191, 13058, 2199, 18574, 13, 16057, 7650, 17, 21, 17, 12111, 13, 7843, 39, 17, 24, 17, 12, 24, 3]}, "items": [{"id": "p_3961", "content": "NRA 0160 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5214, 1019, 17300, 1008, 3, 3]}]}
{"query": {"id": "q_3962", "content": "dopamine [SEP] l) thiazole-2-carboxamide, has a high affinity for human cloned dopamine D4.2, D4.4 and D4.7 receptors, with Ki values of 0.5, 0.9 and 2", "tokenized_content": [2, 7964, 3, 54, 13, 27225, 2456, 17, 22, 17, 15730, 5482, 16, 2258, 43, 2149, 5173, 1958, 2616, 8283, 7964, 16603, 18, 22, 16, 16603, 18, 24, 1930, 16603, 18, 3]}, "items": [{"id": "p_3962", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_3963", "content": "serotonin [SEP] inity for the human cloned dopamine D3 receptor (Ki=39 nM), rat serotonin (5-HT)2A receptors (Ki=180 nM) and rat alpha1 adrenoceptor (Ki=", "tokenized_content": [2, 11153, 3, 1922, 1999, 1958, 1920, 2616, 8283, 7964, 11319, 3148, 12, 8191, 33, 3886, 2943, 13, 16, 3067, 11153, 12, 25, 17, 5334, 13, 5251, 4086, 12, 8191, 33, 3]}, "items": [{"id": "p_3963", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3964", "content": "5-HT [SEP] he human cloned dopamine D3 receptor (Ki=39 nM), rat serotonin (5-HT)2A receptors (Ki=180 nM) and rat alpha1 adrenoceptor (Ki=237 nM", "tokenized_content": [2, 25, 17, 5334, 3, 2234, 2616, 8283, 7964, 11319, 3148, 12, 8191, 33, 3886, 2943, 13, 16, 3067, 11153, 12, 25, 17, 5334, 13, 5251, 4086, 12, 8191, 33, 8585, 3]}, "items": [{"id": "p_3964", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_3965", "content": "clozapine [SEP] Ki=180 nM) and rat alpha1 adrenoceptor (Ki=237 nM). NRA0160 and clozapine antagonized locomotor hyperactivity induced by methamphetamine ", "tokenized_content": [2, 24424, 3, 8191, 33, 8585, 2943, 13, 1930, 3067, 4595, 1009, 25090, 12, 8191, 33, 20528, 2943, 13, 18, 5214, 1019, 6924, 5127, 1930, 24424, 29368, 13594, 15534, 2719, 2007, 3]}, "items": [{"id": "p_3965", "content": "Clozapine [SEP] A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system rec", "score": 1, "type": null, "tokenized_content": [2, 24424, 3, 43, 12258, 14523, 17239, 4389, 18774, 2053, 16, 5947, 1966, 1925, 10834, 17581, 5899, 18, 2176, 6876, 2980, 3584, 1927, 4101, 7580, 2433, 2090, 3]}]}
{"query": {"id": "q_3966", "content": "hyperactivity [SEP] ceptor (Ki=237 nM). NRA0160 and clozapine antagonized locomotor hyperactivity induced by methamphetamine (MAP) in mice. NRA0160 and clozapine", "tokenized_content": [2, 15534, 3, 17008, 2684, 12, 8191, 33, 20528, 2943, 13, 18, 5214, 1019, 6924, 5127, 1930, 24424, 29368, 13594, 15534, 2719, 2007, 20375, 12, 4446, 13, 1922, 2518, 18, 5214, 3]}, "items": [{"id": "p_3966", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_3967", "content": "methamphetamine [SEP] 60 and clozapine antagonized locomotor hyperactivity induced by methamphetamine (MAP) in mice. NRA0160 and clozapine antagonized MAP-induced st", "tokenized_content": [2, 20375, 3, 3276, 1930, 24424, 29368, 13594, 15534, 2719, 2007, 20375, 12, 4446, 13, 1922, 2518, 18, 5214, 1019, 6924, 5127, 1930, 24424, 29368, 4446, 17, 2719, 1955, 3]}, "items": [{"id": "p_3967", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_3968", "content": "MAP [SEP] antagonized locomotor hyperactivity induced by methamphetamine (MAP) in mice. NRA0160 and clozapine antagonized MAP-induced stereot", "tokenized_content": [2, 4446, 3, 29368, 13594, 15534, 2719, 2007, 20375, 12, 4446, 13, 1922, 2518, 18, 5214, 1019, 6924, 5127, 1930, 24424, 29368, 4446, 17, 2719, 18028, 3]}, "items": [{"id": "p_3968", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_3969", "content": "catalepsy [SEP] highest dose given. NRA0160 and clozapine significantly induced catalepsy in rats, although their effects did not exceed 50% induction ev", "tokenized_content": [2, 4233, 9431, 1012, 3, 4554, 3253, 3258, 18, 5214, 1019, 6924, 5127, 1930, 24424, 2567, 2719, 4233, 9431, 1012, 1922, 3615, 16, 2876, 2310, 2564, 2811, 2084, 15431, 2761, 9, 3]}, "items": [{"id": "p_3969", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_3970", "content": "apomorphine [SEP] the disruption of prepulse inhibition (PPI) in rats produced by apomorphine. NRA0160 and clozapine significantly shortened the phencyclidin", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 1920, 7561, 1927, 10719, 17765, 3523, 12, 12481, 13, 1922, 3615, 4152, 2007, 11466, 12492, 11119, 7969, 2912, 18, 5214, 1019, 6924, 5127, 1930, 3]}, "items": [{"id": "p_3970", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_3971", "content": "phencyclidine [SEP]  apomorphine. NRA0160 and clozapine significantly shortened the phencyclidine (PCP)-induced prolonged swimming latency in rats in a water maz", "tokenized_content": [2, 3037, 22170, 5802, 3, 11466, 12492, 11119, 7969, 2912, 18, 5214, 1019, 6924, 5127, 1930, 24424, 2567, 17112, 1920, 3037, 22170, 5802, 12, 16412, 13, 17, 2719, 7171, 15781, 9393, 3]}, "items": [{"id": "p_3971", "content": "Phencyclidine [SEP] A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is simila", "score": 1, "type": null, "tokenized_content": [2, 3037, 22170, 5802, 3, 43, 20958, 3522, 2432, 22397, 2251, 1966, 43, 15748, 16111, 16, 1930, 6699, 1966, 43, 3335, 16111, 1958, 5209, 18, 3037, 22170, 5802, 1977, 2328, 19167, 3]}]}
{"query": {"id": "q_3972", "content": "PCP [SEP] RA0160 and clozapine significantly shortened the phencyclidine (PCP)-induced prolonged swimming latency in rats in a water maze tas", "tokenized_content": [2, 16412, 3, 4313, 6924, 5127, 1930, 24424, 2567, 17112, 1920, 3037, 22170, 5802, 12, 16412, 13, 17, 2719, 7171, 15781, 9393, 1922, 3615, 1922, 43, 3224, 14476, 11017, 3]}, "items": [{"id": "p_3972", "content": "Phencyclidine [SEP] A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is simila", "score": 1, "type": null, "tokenized_content": [2, 3037, 22170, 5802, 3, 43, 20958, 3522, 2432, 22397, 2251, 1966, 43, 15748, 16111, 16, 1930, 6699, 1966, 43, 3335, 16111, 1958, 5209, 18, 3037, 22170, 5802, 1977, 2328, 19167, 3]}]}
{"query": {"id": "q_3973", "content": "cholestasis [SEP] Prolonged cholestasis after troleandomycin-induced acute hepatitis.", "tokenized_content": [2, 30086, 3, 7171, 30086, 2256, 12730, 1952, 24922, 4636, 17, 2719, 3939, 7977, 18, 3]}, "items": [{"id": "p_3973", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3974", "content": "troleandomycin [SEP] Prolonged cholestasis after troleandomycin-induced acute hepatitis.", "tokenized_content": [2, 12730, 1952, 24922, 4636, 3, 7171, 30086, 2256, 12730, 1952, 24922, 4636, 17, 2719, 3939, 7977, 18, 3]}, "items": [{"id": "p_3974", "content": "Troleandomycin [SEP] A macrolide antibiotic that is similar to ERYTHROMYCIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12730, 1952, 24922, 4636, 3, 43, 23929, 2261, 7267, 1988, 1977, 2551, 1942, 22925, 18, 3]}]}
{"query": {"id": "q_3975", "content": "hepatitis [SEP] Prolonged cholestasis after troleandomycin-induced acute hepatitis.", "tokenized_content": [2, 7977, 3, 7171, 30086, 2256, 12730, 1952, 24922, 4636, 17, 2719, 3939, 7977, 18, 3]}, "items": [{"id": "p_3975", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3976", "content": "troleandomycin [SEP] We report the case of a patient in whom troleandomycin-induced hepatitis was followed by prolonged anicteric cholestas", "tokenized_content": [2, 12730, 1952, 24922, 4636, 3, 2038, 3809, 1920, 3087, 1927, 43, 2774, 1922, 8566, 12730, 1952, 24922, 4636, 17, 2719, 7977, 1982, 3489, 2007, 7171, 1925, 5847, 3383, 21211, 1934, 3]}, "items": [{"id": "p_3976", "content": "Troleandomycin [SEP] A macrolide antibiotic that is similar to ERYTHROMYCIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12730, 1952, 24922, 4636, 3, 43, 23929, 2261, 7267, 1988, 1977, 2551, 1942, 22925, 18, 3]}]}
{"query": {"id": "q_3977", "content": "hepatitis [SEP] We report the case of a patient in whom troleandomycin-induced hepatitis was followed by prolonged anicteric cholestasis. Jaundice occur", "tokenized_content": [2, 7977, 3, 2038, 3809, 1920, 3087, 1927, 43, 2774, 1922, 8566, 12730, 1952, 24922, 4636, 17, 2719, 7977, 1982, 3489, 2007, 7171, 1925, 5847, 3383, 30086, 18, 25314, 4704, 3]}, "items": [{"id": "p_3977", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_3978", "content": "cholestasis [SEP] andomycin-induced hepatitis was followed by prolonged anicteric cholestasis. Jaundice occurred after administration of troleandomycin for 7", "tokenized_content": [2, 30086, 3, 1930, 7928, 17, 2719, 7977, 1982, 3489, 2007, 7171, 1925, 5847, 3383, 30086, 18, 25314, 4807, 2256, 4183, 1927, 12730, 1952, 24922, 4636, 1958, 27, 3]}, "items": [{"id": "p_3978", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_3979", "content": "Jaundice [SEP] uced hepatitis was followed by prolonged anicteric cholestasis. Jaundice occurred after administration of troleandomycin for 7 days and ", "tokenized_content": [2, 25314, 3, 8577, 1919, 7977, 1982, 3489, 2007, 7171, 1925, 5847, 3383, 30086, 18, 25314, 4807, 2256, 4183, 1927, 12730, 1952, 24922, 4636, 1958, 27, 3000, 1930, 3]}, "items": [{"id": "p_3979", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_3980", "content": "hypereosinophilia [SEP] nistration of troleandomycin for 7 days and was associated with hypereosinophilia. Jaundice disappeared within 3 months but was followed by prolo", "tokenized_content": [2, 24004, 5872, 19740, 3, 17299, 6003, 1927, 12730, 1952, 24922, 4636, 1958, 27, 3000, 1930, 1982, 2458, 1956, 24004, 5872, 19740, 18, 25314, 15588, 2651, 23, 3221, 2308, 1982, 3489, 3]}, "items": [{"id": "p_3980", "content": "Eosinophilia [SEP] Abnormal increase of EOSINOPHILS in the blood, tissues or organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26887, 3, 4552, 2760, 1927, 15854, 1922, 1920, 2877, 16, 3878, 2014, 7393, 18, 3]}]}
{"query": {"id": "q_3981", "content": "pruritus [SEP] s but was followed by prolonged anicteric cholestasis marked by pruritus and high levels of alkaline phosphatase and gammaglutamyltransf", "tokenized_content": [2, 27496, 3, 61, 2308, 1982, 3489, 2007, 7171, 1925, 5847, 3383, 30086, 4961, 2007, 27496, 1930, 2149, 2428, 1927, 10746, 8167, 1930, 7034, 16542, 27302, 5412, 1038, 3]}, "items": [{"id": "p_3981", "content": "Pruritus [SEP] An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27496, 3, 1925, 10702, 20687, 1941, 15826, 1988, 9300, 1920, 11460, 1021, 1942, 10010, 2014, 18480, 1920, 4407, 1942, 5649, 13104, 18, 3]}]}
{"query": {"id": "q_3982", "content": "Lovastatin [SEP] Lovastatin and simvastatin are the 2 best-known members of the class of hy", "tokenized_content": [2, 18412, 11680, 3, 18412, 11680, 1930, 21555, 2032, 1920, 22, 4534, 17, 3171, 4678, 1927, 1920, 2921, 1927, 4527, 3]}, "items": [{"id": "p_3982", "content": "Lovastatin [SEP] A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits", "score": 1, "type": null, "tokenized_content": [2, 18412, 11680, 3, 43, 8697, 9483, 3937, 2037, 5054, 1927, 17604, 11420, 3708, 1036, 18, 1920, 3547, 1977, 43, 6828, 5851, 27971, 2156, 1959, 4913, 5899, 18, 2176, 7042, 3]}]}
{"query": {"id": "q_3983", "content": "simvastatin [SEP] Lovastatin and simvastatin are the 2 best-known members of the class of hypolipidaemic age", "tokenized_content": [2, 21555, 3, 18412, 11680, 1930, 21555, 2032, 1920, 22, 4534, 17, 3171, 4678, 1927, 1920, 2921, 1927, 14395, 8257, 10828, 4913, 2632, 3]}, "items": [{"id": "p_3983", "content": "Simvastatin [SEP] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLU", "score": 1, "type": null, "tokenized_content": [2, 21555, 3, 43, 10533, 1927, 18412, 11680, 1930, 6828, 10362, 4106, 1927, 23, 17, 8275, 17, 23, 17, 4963, 16542, 26029, 22051, 43, 11386, 12, 29078, 4365, 1032, 3]}]}
{"query": {"id": "q_3984", "content": "lovastatin [SEP] known as HMG CoA reductase inhibitors. Clinical experience with lovastatin includes over 5000 patients, 700 of whom have been treated for ", "tokenized_content": [2, 18412, 11680, 3, 3171, 1966, 12058, 10027, 11386, 4472, 18, 2535, 4848, 1956, 18412, 11680, 5921, 2338, 13576, 2132, 16, 11851, 1927, 8566, 2162, 2252, 2868, 1958, 3]}, "items": [{"id": "p_3984", "content": "Lovastatin [SEP] A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits", "score": 1, "type": null, "tokenized_content": [2, 18412, 11680, 3, 43, 8697, 9483, 3937, 2037, 5054, 1927, 17604, 11420, 3708, 1036, 18, 1920, 3547, 1977, 43, 6828, 5851, 27971, 2156, 1959, 4913, 5899, 18, 2176, 7042, 3]}]}
{"query": {"id": "q_3985", "content": "cholesterol [SEP] ts show substantial clinical efficacy, with reductions in total cholesterol of over 30% and in LDL-cholesterol of 40% in clinical studies. ", "tokenized_content": [2, 5463, 3, 4894, 2146, 6317, 2535, 4348, 16, 1956, 9350, 1922, 2698, 5463, 1927, 2338, 2627, 9, 1930, 1922, 8017, 17, 5463, 1927, 3040, 9, 1922, 2535, 2351, 18, 3]}, "items": [{"id": "p_3985", "content": "Cholesterol [SEP] The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fat", "score": 1, "type": null, "tokenized_content": [2, 5463, 3, 1920, 7944, 20408, 1927, 2136, 2580, 3555, 16, 6533, 1922, 3362, 3878, 16, 4369, 1920, 3068, 1930, 6071, 6670, 16, 1930, 1922, 4027, 3777, 3]}]}
{"query": {"id": "q_3986", "content": "creatine [SEP] nd reversible when therapy is discontinued. Minor elevations of creatine kinase levels are reported in about 5% of patients. Myopathy, a", "tokenized_content": [2, 17784, 3, 8026, 10743, 2469, 3181, 1977, 16087, 18, 5857, 17554, 1927, 17784, 4016, 2428, 2032, 2568, 1922, 3001, 25, 9, 1927, 2132, 18, 25017, 16, 43, 3]}, "items": [{"id": "p_3986", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_3987", "content": "Myopathy [SEP] of creatine kinase levels are reported in about 5% of patients. Myopathy, associated in some cases with myoglobinuria, and in 2 cases wi", "tokenized_content": [2, 25017, 3, 1927, 17784, 4016, 2428, 2032, 2568, 1922, 3001, 25, 9, 1927, 2132, 18, 25017, 16, 2458, 1922, 2673, 2919, 1956, 15924, 4365, 17428, 1022, 8754, 16, 1930, 1922, 3]}, "items": [{"id": "p_3987", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_3988", "content": "myoglobinuria [SEP] n about 5% of patients. Myopathy, associated in some cases with myoglobinuria, and in 2 cases with transient renal failure, has been rarely r", "tokenized_content": [2, 15924, 4365, 17428, 1022, 8754, 3, 56, 3001, 25, 9, 1927, 2132, 18, 25017, 16, 2458, 1922, 2673, 2919, 1956, 15924, 4365, 17428, 1022, 8754, 16, 1930, 1922, 22, 2919, 3]}, "items": [{"id": "p_3988", "content": "Myoglobinuria [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15924, 4365, 17428, 1022, 8754, 3, 3]}]}
{"query": {"id": "q_3989", "content": "renal failure [SEP] in some cases with myoglobinuria, and in 2 cases with transient renal failure, has been rarely reported with lovastatin, especially in patien", "tokenized_content": [2, 4604, 4574, 3, 1922, 2673, 2919, 1956, 15924, 4365, 17428, 1022, 8754, 16, 1930, 1922, 22, 2919, 1956, 6809, 4604, 4574, 16, 2258, 2252, 9671, 2568, 1956, 18412, 11680, 16, 3]}, "items": [{"id": "p_3989", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_3990", "content": "cyclosporin [SEP] h lovastatin, especially in patients concomitantly treated with cyclosporin, gemfibrozil or niacin. Lovastatin and simvastatin are both eff", "tokenized_content": [2, 17640, 1921, 3, 50, 18412, 11680, 16, 4369, 1922, 2132, 19842, 2868, 1956, 17640, 1921, 16, 10607, 19894, 18474, 22030, 1024, 2014, 21946, 3665, 18, 18412, 11680, 1930, 21555, 2032, 3]}, "items": [{"id": "p_3990", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_3991", "content": "gemfibrozil [SEP]  especially in patients concomitantly treated with cyclosporin, gemfibrozil or niacin. Lovastatin and simvastatin are both effective and we", "tokenized_content": [2, 10607, 19894, 18474, 22030, 1024, 3, 4369, 1922, 2132, 19842, 2868, 1956, 17640, 1921, 16, 10607, 19894, 18474, 22030, 1024, 2014, 21946, 3665, 18, 18412, 11680, 1930, 21555, 2032, 2321, 3]}, "items": [{"id": "p_3991", "content": "Gemfibrozil [SEP] A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction", "score": 1, "type": null, "tokenized_content": [2, 10607, 19894, 18474, 22030, 1024, 3, 43, 4486, 17, 6773, 5899, 1988, 25617, 4664, 3256, 8238, 5985, 2007, 7742, 3256, 13631, 1956, 43, 4650, 3378, 3]}]}
{"query": {"id": "q_3992", "content": "niacin [SEP] patients concomitantly treated with cyclosporin, gemfibrozil or niacin. Lovastatin and simvastatin are both effective and well-tolerat", "tokenized_content": [2, 21946, 3665, 3, 2132, 19842, 2868, 1956, 17640, 1921, 16, 10607, 19894, 18474, 22030, 1024, 2014, 21946, 3665, 18, 18412, 11680, 1930, 21555, 2032, 2321, 3655, 1930, 2486, 17, 4977, 3]}, "items": [{"id": "p_3992", "content": "Niacin [SEP] A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the forma", "score": 1, "type": null, "tokenized_content": [2, 21946, 3665, 3, 43, 3224, 17, 6622, 6111, 1927, 1920, 44, 2796, 6966, 1922, 3425, 4027, 1930, 4496, 3878, 18, 2176, 1977, 3414, 2007, 1920, 3362, 1958, 1920, 2386, 1019, 3]}]}
{"query": {"id": "q_3993", "content": "hypercholesterolaemia [SEP]  will gain increasing importance in the therapeutic approach to hypercholesterolaemia and its consequences.", "tokenized_content": [2, 19284, 12392, 3, 2832, 5938, 3605, 4737, 1922, 1920, 4272, 2998, 1942, 19284, 12392, 1930, 2496, 7080, 18, 3]}, "items": [{"id": "p_3993", "content": "Hypercholesterolemia [SEP] A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th per", "score": 1, "type": null, "tokenized_content": [2, 22862, 3, 43, 2625, 1956, 20756, 2149, 2428, 1927, 5463, 1922, 1920, 2877, 18, 2176, 1977, 3608, 1966, 43, 5463, 3113, 15547, 1920, 28463, 2079, 3]}]}
{"query": {"id": "q_3994", "content": "Sulfasalazine [SEP] Sulfasalazine-induced lupus erythematosus.", "tokenized_content": [2, 5141, 14046, 10119, 3, 5141, 14046, 10119, 17, 2719, 13711, 22045, 18, 3]}, "items": [{"id": "p_3994", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_3995", "content": "lupus erythematosus [SEP] Sulfasalazine-induced lupus erythematosus.", "tokenized_content": [2, 13711, 22045, 3, 5141, 14046, 10119, 17, 2719, 13711, 22045, 18, 3]}, "items": [{"id": "p_3995", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_3996", "content": "Pneumonitis [SEP] Pneumonitis, bilateral pleural effusions, echocardiographic evidence of car", "tokenized_content": [2, 24560, 3678, 3, 24560, 3678, 16, 7787, 14117, 17673, 1036, 16, 18700, 3095, 1927, 2279, 3]}, "items": [{"id": "p_3996", "content": "Pneumonia [SEP] Inflammation of any part, segment or lobe, of the lung parenchyma.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7868, 3, 4531, 1927, 2967, 3131, 16, 5367, 2014, 9581, 16, 1927, 1920, 3614, 15214, 18, 3]}]}
{"query": {"id": "q_3997", "content": "pleural effusions [SEP] Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive ", "tokenized_content": [2, 14117, 17673, 1036, 3, 24560, 3678, 16, 7787, 14117, 17673, 1036, 16, 18700, 3095, 1927, 4435, 28060, 12502, 3695, 16, 1930, 2843, 3]}, "items": [{"id": "p_3997", "content": "Pleural Effusion [SEP] Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a si", "score": 1, "type": null, "tokenized_content": [2, 14117, 17673, 3, 2990, 1927, 5466, 1922, 1920, 14117, 8568, 3864, 2037, 9122, 2127, 19856, 1929, 2014, 18787, 1943, 2037, 1920, 14117, 7553, 18, 2176, 1977, 43, 5998, 3]}]}
{"query": {"id": "q_3998", "content": "cardiac tamponade [SEP] tis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, wh", "tokenized_content": [2, 4435, 28060, 12502, 3695, 3, 30152, 16, 7787, 14117, 17673, 1036, 16, 18700, 3095, 1927, 4435, 28060, 12502, 3695, 16, 1930, 2843, 15510, 3530, 1922, 43, 3941, 17, 2476, 17, 3]}, "items": [{"id": "p_3998", "content": "Cardiac Tamponade [SEP] Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding t", "score": 1, "type": null, "tokenized_content": [2, 4435, 28060, 12502, 3695, 3, 10399, 1927, 1920, 4003, 2007, 10508, 5466, 12, 22188, 17673, 13, 2014, 2877, 12, 3243, 3556, 6102, 8544, 2457, 13, 1922, 1920, 10796, 26872, 7510, 62, 3]}]}
{"query": {"id": "q_3999", "content": "sulfasalazine [SEP] ies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis. After cessation of the ", "tokenized_content": [2, 5141, 14046, 10119, 3, 10116, 1036, 3530, 1922, 43, 3941, 17, 2476, 17, 4156, 2323, 16, 2746, 1982, 5962, 2815, 17, 2576, 5141, 14046, 10119, 3181, 1958, 3724, 20428, 12087, 3]}, "items": [{"id": "p_3999", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_4000", "content": "ulcerative colitis [SEP] , who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis. After cessation of the sulfasalazine and completion of a six-w", "tokenized_content": [2, 20428, 12087, 3, 16, 2746, 1982, 5962, 2815, 17, 2576, 5141, 14046, 10119, 3181, 1958, 3724, 20428, 12087, 18, 2256, 10975, 1927, 1920, 5141, 14046, 10119, 1930, 9297, 1927, 43, 3]}, "items": [{"id": "p_4000", "content": "Colitis, Ulcerative [SEP] Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, th", "score": 1, "type": null, "tokenized_content": [2, 12087, 16, 20428, 3, 4531, 1927, 1920, 4120, 1988, 1977, 7700, 13184, 1942, 1920, 9680, 18, 2496, 3044, 3601, 3951, 11904, 16, 11635, 7633, 16, 1913, 3]}]}
{"query": {"id": "q_4001", "content": "lupus [SEP] ths. It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal invo", "tokenized_content": [2, 13711, 3, 1913, 1036, 18, 2176, 1977, 3978, 1988, 1920, 2774, 2430, 5141, 14046, 10119, 17, 2719, 13711, 16, 2154, 16687, 1956, 2375, 19976, 1930, 5352, 19223, 2269, 1037, 3]}, "items": [{"id": "p_4001", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_4002", "content": "serositis [SEP]  patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint s", "tokenized_content": [2, 2375, 19976, 3, 2774, 2430, 5141, 14046, 10119, 17, 2719, 13711, 16, 2154, 16687, 1956, 2375, 19976, 1930, 5352, 19223, 5668, 1922, 1920, 3905, 1927, 6047, 61, 3]}, "items": [{"id": "p_4002", "content": "Serositis [SEP] Inflammation of a serous membrane.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2375, 19976, 3, 4531, 1927, 43, 19965, 3260, 18, 3]}]}
{"query": {"id": "q_4003", "content": "inflammatory bowel disease [SEP] mptoms. Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syn", "tokenized_content": [2, 3769, 9472, 2573, 3, 15840, 18995, 18, 6967, 2746, 2485, 5141, 14046, 10119, 1942, 2297, 2132, 1956, 3769, 9472, 2573, 3066, 1998, 11207, 1927, 1920, 6879, 1927, 5141, 14046, 10119, 3]}, "items": [{"id": "p_4003", "content": "Inflammatory Bowel Diseases [SEP] Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes C", "score": 1, "type": null, "tokenized_content": [2, 3769, 9472, 3902, 3, 3724, 16, 2447, 17, 2487, 4531, 1927, 1920, 8375, 6482, 18, 10383, 2278, 1998, 3299, 2014, 4813, 18, 2052, 2576, 5921, 45, 3]}]}
{"query": {"id": "q_4004", "content": "lupus syndrome [SEP] l disease should be aware of the signs of sulfasalazine-induced lupus syndrome.", "tokenized_content": [2, 13711, 4741, 3, 54, 2573, 3066, 1998, 11207, 1927, 1920, 6879, 1927, 5141, 14046, 10119, 17, 2719, 13711, 4741, 18, 3]}, "items": [{"id": "p_4004", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_4005", "content": "levodopa [SEP] Optimization of levodopa therapy.", "tokenized_content": [2, 26723, 3, 9399, 1927, 26723, 3181, 18, 3]}, "items": [{"id": "p_4005", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4006", "content": "levodopa [SEP] While there is no single correct starting dose for levodopa therapy, many individuals can be started on either the 25/100 o", "tokenized_content": [2, 26723, 3, 2679, 2276, 1977, 2239, 2957, 5550, 6801, 3253, 1958, 26723, 3181, 16, 3086, 3445, 2112, 1998, 8074, 1990, 3108, 1920, 2637, 19, 2813, 57, 3]}, "items": [{"id": "p_4006", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4007", "content": "carbidopa [SEP] e formula, following the general rule not to attempt to titrate carbidopa-levodopa to the point of \"normality,\" which can lead to toxicit", "tokenized_content": [2, 3697, 15072, 4302, 3, 47, 9378, 16, 2894, 1920, 3335, 8728, 2084, 1942, 9289, 1942, 11038, 2010, 3697, 15072, 4302, 17, 26723, 1942, 1920, 3575, 1927, 6, 16544, 16, 6, 3]}, "items": [{"id": "p_4007", "content": "Carbidopa [SEP] An inhibitor of DOPA DECARBOXYLASE, preventing conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce per", "score": 1, "type": null, "tokenized_content": [2, 3697, 15072, 4302, 3, 1925, 4106, 1927, 19428, 23922, 16, 8444, 7309, 1927, 26723, 1942, 7964, 18, 2176, 1977, 2251, 1922, 10124, 2573, 1942, 4412, 2079, 3]}]}
{"query": {"id": "q_4008", "content": "toxicity [SEP] rbidopa-levodopa to the point of \"normality,\" which can lead to toxicity. The physician should also determine the proper use of any adju", "tokenized_content": [2, 5532, 3, 6160, 15072, 4302, 17, 26723, 1942, 1920, 3575, 1927, 6, 16544, 16, 6, 2154, 2112, 2949, 1942, 5532, 18, 1920, 7946, 3066, 2222, 3415, 1920, 3405, 2485, 1927, 3]}, "items": [{"id": "p_4008", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4009", "content": "dopamine [SEP] utic approaches, such as dosage adjustment or introduction of a dopamine agonist. Other possible adverse effects--such as gastrointestin", "tokenized_content": [2, 7964, 3, 21472, 1030, 4895, 16, 2427, 1966, 9998, 7970, 2014, 6935, 1927, 43, 7964, 7829, 18, 2303, 3216, 5246, 2564, 17, 17, 2427, 1966, 6858, 2879, 2158, 1921, 3]}, "items": [{"id": "p_4009", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4010", "content": "gastrointestinal disorders [SEP]  of a dopamine agonist. Other possible adverse effects--such as gastrointestinal disorders, orthostatic hypotension, levodopa-induced psychosis, sleep dis", "tokenized_content": [2, 8375, 4414, 3, 1927, 43, 7964, 7829, 18, 2303, 3216, 5246, 2564, 17, 17, 2427, 1966, 8375, 4414, 16, 24343, 11494, 16453, 16, 26723, 17, 2719, 15489, 16, 5006, 2054, 3]}, "items": [{"id": "p_4010", "content": "Gastrointestinal Diseases [SEP] Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8375, 3902, 3, 3902, 1922, 2967, 5367, 1927, 1920, 8375, 6482, 2037, 16749, 1942, 19773, 18, 3]}]}
{"query": {"id": "q_4011", "content": "orthostatic hypotension [SEP] r possible adverse effects--such as gastrointestinal disorders, orthostatic hypotension, levodopa-induced psychosis, sleep disturbances or parasomnias,", "tokenized_content": [2, 24343, 11494, 16453, 3, 60, 3216, 5246, 2564, 17, 17, 2427, 1966, 8375, 4414, 16, 24343, 11494, 16453, 16, 26723, 17, 2719, 15489, 16, 5006, 12654, 2014, 5336, 16393, 1036, 3]}, "items": [{"id": "p_4011", "content": "Hypotension, Orthostatic [SEP] A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a ", "score": 1, "type": null, "tokenized_content": [2, 16453, 16, 24343, 11494, 3, 43, 2228, 7086, 1922, 2877, 3772, 2256, 10511, 43, 11982, 3507, 18, 24343, 11494, 16453, 1977, 43, 2849, 16, 1930, 3608, 1966, 43, 3]}]}
{"query": {"id": "q_4012", "content": "psychosis [SEP] intestinal disorders, orthostatic hypotension, levodopa-induced psychosis, sleep disturbances or parasomnias, or drug interactions--also ", "tokenized_content": [2, 15489, 3, 6139, 4414, 16, 24343, 11494, 16453, 16, 26723, 17, 2719, 15489, 16, 5006, 12654, 2014, 5336, 16393, 1036, 16, 2014, 2838, 3719, 17, 17, 2222, 3]}, "items": [{"id": "p_4012", "content": "Psychotic Disorders [SEP] Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent halluc", "score": 1, "type": null, "tokenized_content": [2, 16651, 4414, 3, 4414, 1922, 2154, 2276, 1977, 43, 3257, 1927, 7282, 1037, 11471, 2014, 43, 10461, 6159, 1922, 15928, 4213, 1956, 2723, 3910, 2014, 8753, 20958, 3]}]}
{"query": {"id": "q_4013", "content": "sleep disturbances [SEP] disorders, orthostatic hypotension, levodopa-induced psychosis, sleep disturbances or parasomnias, or drug interactions--also require carefully mo", "tokenized_content": [2, 5006, 12654, 3, 4414, 16, 24343, 11494, 16453, 16, 26723, 17, 2719, 15489, 16, 5006, 12654, 2014, 5336, 16393, 1036, 16, 2014, 2838, 3719, 17, 17, 2222, 4350, 10801, 2661, 3]}, "items": [{"id": "p_4013", "content": "Sleep Disorders [SEP] Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major c", "score": 1, "type": null, "tokenized_content": [2, 5006, 4414, 3, 2961, 4378, 2007, 12654, 1927, 10616, 5006, 4147, 2014, 5888, 18, 5006, 4414, 2278, 1998, 5831, 2460, 2559, 3044, 45, 3]}]}
{"query": {"id": "q_4014", "content": "parasomnias [SEP]  hypotension, levodopa-induced psychosis, sleep disturbances or parasomnias, or drug interactions--also require carefully monitored individ", "tokenized_content": [2, 5336, 16393, 1036, 3, 16453, 16, 26723, 17, 2719, 15489, 16, 5006, 12654, 2014, 5336, 16393, 1036, 16, 2014, 2838, 3719, 17, 17, 2222, 4350, 10801, 7027, 2692, 3]}, "items": [{"id": "p_4014", "content": "Parasomnias [SEP] Movements or behaviors associated with sleep, sleep stages, or partial arousals from sleep that may impair sleep maintenance. Pa", "score": 1, "type": null, "tokenized_content": [2, 5336, 16393, 1036, 3, 8264, 2014, 5888, 2458, 1956, 5006, 16, 5006, 5143, 16, 2014, 5740, 14216, 1036, 2037, 5006, 1988, 2278, 3960, 5006, 6291, 18, 3838, 3]}]}
{"query": {"id": "q_4015", "content": "Parkinson's disease [SEP] ed individual treatment. Nonpharmacologic concerns can help the Parkinson's disease patient achieve and maintain optimal functioning, including dai", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 3347, 2725, 2311, 18, 24857, 28476, 26016, 4467, 8103, 2112, 4087, 1920, 10124, 11, 61, 2573, 2774, 6230, 1930, 6698, 5419, 7295, 16, 2710, 23708, 3]}, "items": [{"id": "p_4015", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_4016", "content": "coma [SEP] Alpha and beta coma in drug intoxication uncomplicated by cerebral hypoxia.", "tokenized_content": [2, 22337, 3, 4595, 1930, 4666, 22337, 1922, 2838, 20965, 22050, 2007, 6329, 7264, 18, 3]}, "items": [{"id": "p_4016", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_4017", "content": "cerebral hypoxia [SEP] Alpha and beta coma in drug intoxication uncomplicated by cerebral hypoxia.", "tokenized_content": [2, 6329, 7264, 3, 4595, 1930, 4666, 22337, 1922, 2838, 20965, 22050, 2007, 6329, 7264, 18, 3]}, "items": [{"id": "p_4017", "content": "Hypoxia, Brain [SEP] A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to ", "score": 1, "type": null, "tokenized_content": [2, 7264, 16, 3068, 3, 43, 3378, 1922, 3068, 4612, 9042, 2810, 1942, 28976, 1039, 3847, 12, 43, 3028, 4351, 1927, 4612, 3301, 4371, 1922, 1920, 2877, 2007, 9652, 13, 16, 2014, 1942, 3]}]}
{"query": {"id": "q_4018", "content": "comatose [SEP] Four patients who were rendered comatose or stuporous by drug intoxication, but who were not hypoxic, ar", "tokenized_content": [2, 22337, 4575, 4127, 3, 3006, 2132, 2746, 1985, 18416, 22337, 4575, 4127, 2014, 1955, 3481, 9938, 2007, 2838, 20965, 16, 2308, 2746, 1985, 2084, 11277, 16, 2245, 3]}, "items": [{"id": "p_4018", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_4019", "content": "stuporous [SEP] Four patients who were rendered comatose or stuporous by drug intoxication, but who were not hypoxic, are described. ", "tokenized_content": [2, 1955, 3481, 9938, 3, 3006, 2132, 2746, 1985, 18416, 22337, 4575, 4127, 2014, 1955, 3481, 9938, 2007, 2838, 20965, 16, 2308, 2746, 1985, 2084, 11277, 16, 2032, 2910, 18, 3]}, "items": [{"id": "p_4019", "content": "Stupor [SEP] A state of reduced sensibility and response to stimuli which is distinguished from COMA in that the person can be aroused by vig", "score": 1, "type": null, "tokenized_content": [2, 1955, 3481, 1924, 3, 43, 3360, 1927, 3028, 2658, 3687, 1930, 2644, 1942, 5458, 2154, 1977, 12080, 2037, 22337, 1922, 1988, 1920, 5952, 2112, 1998, 12529, 6107, 2007, 11505, 3]}]}
{"query": {"id": "q_4020", "content": "chlormethiazole [SEP] t hypoxic, are described. Three patients received high doses of chlormethiazole for alcohol withdrawal symptoms, and one took a suicidal overdo", "tokenized_content": [2, 4891, 23568, 19810, 3, 62, 11277, 16, 2032, 2910, 18, 2559, 2132, 4004, 2149, 5312, 1927, 4891, 23568, 19810, 1958, 4284, 9594, 3601, 16, 1930, 2340, 8659, 43, 14759, 17612, 3]}, "items": [{"id": "p_4020", "content": "Chlormethiazole [SEP] A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neu", "score": 1, "type": null, "tokenized_content": [2, 4891, 23568, 19810, 3, 43, 28514, 1930, 26572, 2031, 3868, 2251, 1922, 1920, 2311, 1927, 4284, 9594, 18, 4891, 23568, 19810, 2258, 2222, 2252, 4211, 1966, 43, 2866, 3]}]}
{"query": {"id": "q_4021", "content": "alcohol [SEP] ibed. Three patients received high doses of chlormethiazole for alcohol withdrawal symptoms, and one took a suicidal overdose of nitraz", "tokenized_content": [2, 4284, 3, 6180, 1919, 18, 2559, 2132, 4004, 2149, 5312, 1927, 4891, 23568, 19810, 1958, 4284, 9594, 3601, 16, 1930, 2340, 8659, 43, 14759, 21090, 1927, 8214, 3408, 3]}, "items": [{"id": "p_4021", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_4022", "content": "withdrawal symptoms [SEP] ree patients received high doses of chlormethiazole for alcohol withdrawal symptoms, and one took a suicidal overdose of nitrazepam. The patient wi", "tokenized_content": [2, 9594, 3601, 3, 21747, 2132, 4004, 2149, 5312, 1927, 4891, 23568, 19810, 1958, 4284, 9594, 3601, 16, 1930, 2340, 8659, 43, 14759, 21090, 1927, 8214, 28231, 18, 1920, 2774, 11980, 3]}, "items": [{"id": "p_4022", "content": "Substance Withdrawal Syndrome [SEP] Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or hab", "score": 1, "type": null, "tokenized_content": [2, 7311, 9594, 4741, 3, 5005, 1930, 6674, 3601, 2458, 1956, 9594, 2037, 1920, 2485, 1927, 43, 2838, 2256, 7171, 4183, 2014, 6192, 3]}]}
{"query": {"id": "q_4023", "content": "overdose [SEP] iazole for alcohol withdrawal symptoms, and one took a suicidal overdose of nitrazepam. The patient with nitrazepam overdose and two of ", "tokenized_content": [2, 21090, 3, 11640, 13642, 1952, 1958, 4284, 9594, 3601, 16, 1930, 2340, 8659, 43, 14759, 21090, 1927, 8214, 28231, 18, 1920, 2774, 1956, 8214, 28231, 21090, 1930, 2288, 1927, 3]}, "items": [{"id": "p_4023", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4024", "content": "nitrazepam [SEP] lcohol withdrawal symptoms, and one took a suicidal overdose of nitrazepam. The patient with nitrazepam overdose and two of those with chl", "tokenized_content": [2, 8214, 28231, 3, 5236, 2977, 1945, 9594, 3601, 16, 1930, 2340, 8659, 43, 14759, 21090, 1927, 8214, 28231, 18, 1920, 2774, 1956, 8214, 28231, 21090, 1930, 2288, 1927, 2690, 1956, 3]}, "items": [{"id": "p_4024", "content": "Nitrazepam [SEP] A benzodiazepine derivative used as an anticonvulsant and hypnotic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8214, 28231, 3, 43, 27266, 10533, 2251, 1966, 1925, 26572, 2031, 1930, 25810, 3153, 18, 3]}]}
{"query": {"id": "q_4025", "content": "coma [SEP] Four patients who were rendered comatose or stuporous by drug intoxication, but who were not hypoxic", "tokenized_content": [2, 22337, 3, 3006, 2132, 2746, 1985, 18416, 22337, 4575, 4127, 2014, 1955, 3481, 9938, 2007, 2838, 20965, 16, 2308, 2746, 1985, 2084, 11277, 3]}, "items": [{"id": "p_4025", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_4026", "content": "neurological sequelae [SEP] y in the slow beta range. All four recovered completely without neurological sequelae following the withdrawal of the offending agents. The similarit", "tokenized_content": [2, 7605, 19067, 3, 67, 1922, 1920, 5470, 4666, 3109, 18, 2136, 3006, 8294, 5796, 2979, 7605, 19067, 2894, 1920, 9594, 1927, 1920, 4013, 4792, 4820, 18, 1920, 2551, 1932, 3]}, "items": [{"id": "p_4026", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4027", "content": "depression [SEP] s between the effects of structural lesions and pharmacological depression of the brain stem reticular formation are discussed. It is sugg", "tokenized_content": [2, 4621, 3, 61, 2192, 1920, 2564, 1927, 4346, 4518, 1930, 7683, 4621, 1927, 1920, 3068, 4402, 23734, 3337, 2032, 5601, 18, 2176, 1977, 2425, 1029, 3]}, "items": [{"id": "p_4027", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_4028", "content": "hypoxaemia [SEP] ure is seen in drug intoxication, in the absence of significant hypoxaemia, a favourable outcome may be anticipated.", "tokenized_content": [2, 5918, 12392, 3, 6794, 1977, 3945, 1922, 2838, 20965, 16, 1922, 1920, 3905, 1927, 2228, 5918, 12392, 16, 43, 18845, 3924, 2278, 1998, 12909, 18, 3]}, "items": [{"id": "p_4028", "content": "Anoxia [SEP] Relatively complete absence of oxygen in one or more tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28976, 18068, 1019, 3, 4322, 4080, 3905, 1927, 4612, 1922, 2340, 2014, 2253, 3878, 18, 3]}]}
{"query": {"id": "q_4029", "content": "fentanyl [SEP] Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sev", "tokenized_content": [2, 20311, 3, 25752, 2104, 20311, 7268, 13759, 1930, 13954, 16, 2979, 3605, 3594, 16, 2256, 28212, 3]}, "items": [{"id": "p_4029", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_4030", "content": "nausea [SEP] Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for da", "tokenized_content": [2, 13759, 3, 25752, 2104, 20311, 7268, 13759, 1930, 13954, 16, 2979, 3605, 3594, 16, 2256, 25564, 1958, 3692, 3]}, "items": [{"id": "p_4030", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_4031", "content": "vomiting [SEP] Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery.", "tokenized_content": [2, 13954, 3, 25752, 2104, 20311, 7268, 13759, 1930, 13954, 16, 2979, 3605, 3594, 16, 2256, 25564, 1958, 3007, 3782, 18, 3]}, "items": [{"id": "p_4031", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_4032", "content": "pain [SEP] itting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery.", "tokenized_content": [2, 3594, 3, 24930, 1941, 20311, 7268, 13759, 1930, 13954, 16, 2979, 3605, 3594, 16, 2256, 25564, 1958, 3007, 3782, 18, 3]}, "items": [{"id": "p_4032", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4033", "content": "sevoflurane [SEP] nyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery.", "tokenized_content": [2, 25564, 3, 8932, 1024, 7268, 13759, 1930, 13954, 16, 2979, 3605, 3594, 16, 2256, 25564, 1958, 3007, 3782, 18, 3]}, "items": [{"id": "p_4033", "content": "sevoflurane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25564, 3, 3]}]}
{"query": {"id": "q_4034", "content": "sevoflurane [SEP] ite advantages of induction and maintenance of anaesthesia with sevoflurane, postoperative nausea and vomiting occurs frequently. Fentanyl ", "tokenized_content": [2, 25564, 3, 2176, 1021, 8518, 1927, 4408, 1930, 6291, 1927, 17107, 1956, 25564, 16, 5924, 13759, 1930, 13954, 5110, 5467, 18, 20311, 3]}, "items": [{"id": "p_4034", "content": "sevoflurane [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25564, 3, 3]}]}
{"query": {"id": "q_4035", "content": "postoperative nausea and vomiting [SEP] s of induction and maintenance of anaesthesia with sevoflurane, postoperative nausea and vomiting occurs frequently. Fentanyl is a commonly used supplement that ", "tokenized_content": [2, 5924, 13759, 1930, 13954, 3, 61, 1927, 4408, 1930, 6291, 1927, 17107, 1956, 25564, 16, 5924, 13759, 1930, 13954, 5110, 5467, 18, 20311, 1977, 43, 5384, 2251, 3029, 1988, 3]}, "items": [{"id": "p_4035", "content": "Postoperative Nausea and Vomiting [SEP] Emesis and queasiness occurring after anesthesia.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5924, 13759, 1930, 13954, 3, 2391, 2600, 1930, 10730, 20474, 1979, 6966, 2256, 8871, 18, 3]}]}
{"query": {"id": "q_4036", "content": "Fentanyl [SEP] voflurane, postoperative nausea and vomiting occurs frequently. Fentanyl is a commonly used supplement that may contribute to this, alth", "tokenized_content": [2, 20311, 3, 9805, 12676, 16, 5924, 13759, 1930, 13954, 5110, 5467, 18, 20311, 1977, 43, 5384, 2251, 3029, 1988, 2278, 4672, 1942, 2052, 16, 2874, 3]}, "items": [{"id": "p_4036", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_4037", "content": "pain [SEP] incidence and severity of postoperative nausea and vomiting and pain in the first 24 h after sevoflurane anaesthesia in 216 adult da", "tokenized_content": [2, 3594, 3, 4332, 1930, 5155, 1927, 5924, 13759, 1930, 13954, 1930, 3594, 1922, 1920, 2561, 2686, 50, 2256, 25564, 17107, 1922, 17663, 4160, 3692, 3]}, "items": [{"id": "p_4037", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4038", "content": "fentanyl [SEP] ts were randomly allocated to either receive or not receive 1 1 fentanyl, while a third group received dexamethasone in addition to fent", "tokenized_content": [2, 20311, 3, 4894, 1985, 6266, 14553, 1942, 3108, 7130, 2014, 2084, 7130, 21, 21, 20311, 16, 2679, 43, 4563, 2210, 4004, 12681, 1922, 2459, 1942, 17232, 3]}, "items": [{"id": "p_4038", "content": "Fentanyl [SEP] A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is ", "score": 1, "type": null, "tokenized_content": [2, 20311, 3, 43, 6828, 22872, 3153, 14501, 16, 7764, 1927, 2154, 5029, 1942, 22106, 2014, 12067, 18, 2176, 1977, 5985, 43, 8975, 17, 9384, 7829, 18, 20311, 1977, 3]}]}
{"query": {"id": "q_4039", "content": "dexamethasone [SEP] ceive or not receive 1 1 fentanyl, while a third group received dexamethasone in addition to fentanyl. RESULTS: Omission of fentanyl did not ", "tokenized_content": [2, 12681, 3, 5827, 2320, 2014, 2084, 7130, 21, 21, 20311, 16, 2679, 43, 4563, 2210, 4004, 12681, 1922, 2459, 1942, 20311, 18, 2274, 30, 25779, 1927, 20311, 2811, 2084, 3]}, "items": [{"id": "p_4039", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4040", "content": "vomiting [SEP] nance of anaesthesia with sevoflurane, postoperative nausea and vomiting occurs frequently. Fentanyl is a commonly used supplement that ", "tokenized_content": [2, 13954, 3, 3529, 1972, 1927, 17107, 1956, 25564, 16, 5924, 13759, 1930, 13954, 5110, 5467, 18, 20311, 1977, 43, 5384, 2251, 3029, 1988, 3]}, "items": [{"id": "p_4040", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_4041", "content": "nausea [SEP]  and maintenance of anaesthesia with sevoflurane, postoperative nausea and vomiting occurs frequently. Fentanyl is a commonly used sup", "tokenized_content": [2, 13759, 3, 1930, 6291, 1927, 17107, 1956, 25564, 16, 5924, 13759, 1930, 13954, 5110, 5467, 18, 20311, 1977, 43, 5384, 2251, 2302, 3]}, "items": [{"id": "p_4041", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_4042", "content": "Dexamethasone [SEP]  requirements were reduced from 24% and 31% to 7% (P = 0.0012). Dexamethasone had no significant effect on the incidence or severity of posto", "tokenized_content": [2, 12681, 3, 8456, 1985, 3028, 2037, 2686, 9, 1930, 3470, 9, 1942, 27, 9, 12, 58, 33, 20, 18, 3472, 1028, 13, 18, 12681, 2430, 2239, 2228, 2495, 1990, 1920, 3]}, "items": [{"id": "p_4042", "content": "Dexamethasone [SEP] An anti-inflammatory 9-fluoro-glucocorticoid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12681, 3, 1925, 2246, 17, 3769, 29, 17, 16191, 17, 14469, 18, 3]}]}
{"query": {"id": "q_4043", "content": "Pain [SEP] ea in the first 24 h was decreased from 42% to 27% (P = 0.034). Pain severity and analgesic requirements were unaffected by the omis", "tokenized_content": [2, 3594, 3, 11377, 1922, 1920, 2561, 2686, 50, 1982, 3261, 2037, 3858, 9, 1942, 3225, 9, 12, 58, 33, 20, 18, 22207, 13, 18, 3594, 5155, 1930, 14501, 8456, 1985, 3]}, "items": [{"id": "p_4043", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4044", "content": "respiratory depression [SEP] ve movement but had no sevoflurane-sparing effect and increased respiratory depression, hypotension and bradycardia. CONCLUSION: As fentanyl exacerbat", "tokenized_content": [2, 5481, 4621, 3, 3428, 5829, 2308, 2430, 2239, 25564, 17, 17981, 2495, 1930, 2502, 5481, 4621, 16, 16453, 1930, 26192, 18, 4180, 30, 1966, 20311, 9307, 1926, 3]}, "items": [{"id": "p_4044", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_4045", "content": "hypotension [SEP] evoflurane-sparing effect and increased respiratory depression, hypotension and bradycardia. CONCLUSION: As fentanyl exacerbated postoperat", "tokenized_content": [2, 16453, 3, 2180, 4199, 5277, 10513, 17, 17981, 2495, 1930, 2502, 5481, 4621, 16, 16453, 1930, 26192, 18, 4180, 30, 1966, 20311, 19159, 2753, 3556, 1926, 3]}, "items": [{"id": "p_4045", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4046", "content": "bradycardia [SEP] ng effect and increased respiratory depression, hypotension and bradycardia. CONCLUSION: As fentanyl exacerbated postoperative nausea and v", "tokenized_content": [2, 26192, 3, 4375, 2495, 1930, 2502, 5481, 4621, 16, 16453, 1930, 26192, 18, 4180, 30, 1966, 20311, 19159, 5924, 13759, 1930, 64, 3]}, "items": [{"id": "p_4046", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_4047", "content": "postoperative pain [SEP] ted postoperative nausea and vomiting without an improvement in postoperative pain and also had adverse cardiorespiratory effects, it appears to b", "tokenized_content": [2, 5924, 3594, 3, 26080, 5924, 13759, 1930, 13954, 2979, 1925, 4990, 1922, 5924, 3594, 1930, 2222, 2430, 5246, 28158, 2564, 16, 2176, 5107, 1942, 44, 3]}, "items": [{"id": "p_4047", "content": "Pain, Postoperative [SEP] Pain during the period after surgery.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 16, 5924, 3, 3594, 2409, 1920, 3047, 2256, 3782, 18, 3]}]}
{"query": {"id": "q_4048", "content": "Renal Fanconi syndrome [SEP] Renal Fanconi syndrome and myopathy after liver transplantation: drug-related mitochon", "tokenized_content": [2, 4604, 17431, 13339, 4741, 3, 4604, 17431, 13339, 4741, 1930, 25017, 2256, 3568, 6530, 30, 2838, 17, 2712, 25959, 28226, 1022, 3]}, "items": [{"id": "p_4048", "content": "Fanconi Syndrome [SEP] A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY", "score": 1, "type": null, "tokenized_content": [2, 17431, 13339, 4741, 3, 43, 16321, 2014, 5815, 2386, 1927, 9612, 5273, 1927, 1920, 6863, 5245, 17946, 2979, 3065, 5668, 1927, 1920, 5245, 3]}]}
{"query": {"id": "q_4049", "content": "myopathy [SEP] Renal Fanconi syndrome and myopathy after liver transplantation: drug-related mitochondrial cytopat", "tokenized_content": [2, 25017, 3, 4604, 17431, 13339, 4741, 1930, 25017, 2256, 3568, 6530, 30, 2838, 17, 2712, 4596, 22953, 4302, 1031, 3]}, "items": [{"id": "p_4049", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_4050", "content": "mitochondrial cytopathy [SEP] syndrome and myopathy after liver transplantation: drug-related mitochondrial cytopathy?", "tokenized_content": [2, 4596, 22953, 9112, 1012, 3, 4741, 1930, 25017, 2256, 3568, 6530, 30, 2838, 17, 2712, 4596, 22953, 9112, 1012, 35, 3]}, "items": [{"id": "p_4050", "content": "Mitochondrial cytopathy [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4596, 22953, 9112, 1012, 3, 3]}]}
{"query": {"id": "q_4051", "content": "Wilson's disease [SEP] yr-old girl who had orthotopic liver transplantation because of Wilson's disease. Tacrolimus, MMF, and steroids were given as immunosuppressant.", "tokenized_content": [2, 17711, 11, 61, 2573, 3, 13031, 17, 4156, 21676, 2746, 2430, 21306, 3568, 6530, 2882, 1927, 17711, 11, 61, 2573, 18, 21801, 16, 27579, 16, 1930, 13039, 1985, 3258, 1966, 3]}, "items": [{"id": "p_4051", "content": "Hepatolenticular Degeneration [SEP] A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It i", "score": 1, "type": null, "tokenized_content": [2, 5746, 2456, 4905, 4588, 9174, 3, 43, 5844, 13027, 13992, 2573, 4378, 2007, 1920, 7860, 1927, 9541, 1922, 1920, 3068, 31, 3568, 31, 16678, 31, 1930, 2303, 7393, 18, 2176, 51, 3]}]}
{"query": {"id": "q_4052", "content": "Tacrolimus [SEP] d orthotopic liver transplantation because of Wilson's disease. Tacrolimus, MMF, and steroids were given as immunosuppressant. Lamivudine ", "tokenized_content": [2, 21801, 3, 46, 21306, 3568, 6530, 2882, 1927, 17711, 11, 61, 2573, 18, 21801, 16, 27579, 16, 1930, 13039, 1985, 3258, 1966, 27996, 2031, 18, 30208, 3]}, "items": [{"id": "p_4052", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4053", "content": "steroids [SEP] ansplantation because of Wilson's disease. Tacrolimus, MMF, and steroids were given as immunosuppressant. Lamivudine was added because o", "tokenized_content": [2, 13039, 3, 18229, 18751, 2882, 1927, 17711, 11, 61, 2573, 18, 21801, 16, 27579, 16, 1930, 13039, 1985, 3258, 1966, 27996, 2031, 18, 30208, 1982, 4057, 2882, 57, 3]}, "items": [{"id": "p_4053", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4054", "content": "Lamivudine [SEP]  Tacrolimus, MMF, and steroids were given as immunosuppressant. Lamivudine was added because of de nova hepatitis B infection during her f", "tokenized_content": [2, 30208, 3, 21801, 16, 27579, 16, 1930, 13039, 1985, 3258, 1966, 27996, 2031, 18, 30208, 1982, 4057, 2882, 1927, 2028, 6862, 1019, 7977, 44, 2909, 2409, 3656, 48, 3]}, "items": [{"id": "p_4054", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_4055", "content": "hepatitis B infection [SEP] n as immunosuppressant. Lamivudine was added because of de nova hepatitis B infection during her follow-up. Three yr after transplantation she develo", "tokenized_content": [2, 7977, 44, 2909, 3, 56, 1966, 27996, 2031, 18, 30208, 1982, 4057, 2882, 1927, 2028, 6862, 1019, 7977, 44, 2909, 2409, 3656, 2396, 17, 2353, 18, 2559, 13031, 2256, 6530, 3]}, "items": [{"id": "p_4055", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_4056", "content": "renal Fanconi syndrome [SEP] ing her follow-up. Three yr after transplantation she developed renal Fanconi syndrome with severe metabolic acidosis, hypophosphatemia, glycosuria, a", "tokenized_content": [2, 4604, 17431, 13339, 4741, 3, 30393, 3656, 2396, 17, 2353, 18, 2559, 13031, 2256, 6530, 4693, 3530, 4604, 17431, 13339, 4741, 1956, 4010, 4487, 19051, 16, 26497, 10647, 3508, 2722, 3]}, "items": [{"id": "p_4056", "content": "Fanconi Syndrome [SEP] A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY", "score": 1, "type": null, "tokenized_content": [2, 17431, 13339, 4741, 3, 43, 16321, 2014, 5815, 2386, 1927, 9612, 5273, 1927, 1920, 6863, 5245, 17946, 2979, 3065, 5668, 1927, 1920, 5245, 3]}]}
{"query": {"id": "q_4057", "content": "metabolic acidosis [SEP] ransplantation she developed renal Fanconi syndrome with severe metabolic acidosis, hypophosphatemia, glycosuria, and aminoaciduria. Although tacr", "tokenized_content": [2, 4487, 19051, 3, 2845, 3508, 17576, 4926, 4693, 3530, 4604, 17431, 13339, 4741, 1956, 4010, 4487, 19051, 16, 26497, 10647, 3508, 2722, 2057, 6026, 16, 7533, 8754, 16, 1930, 3835, 3]}, "items": [{"id": "p_4057", "content": "Acidosis [SEP] A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and me", "score": 1, "type": null, "tokenized_content": [2, 19051, 3, 43, 11896, 2625, 1927, 2687, 4858, 2014, 6882, 1927, 5170, 1922, 1920, 3362, 18, 1920, 2288, 2730, 3584, 2032, 5481, 19051, 1930, 2142, 3]}]}
{"query": {"id": "q_4058", "content": "hypophosphatemia [SEP] eveloped renal Fanconi syndrome with severe metabolic acidosis, hypophosphatemia, glycosuria, and aminoaciduria. Although tacrolimus was suspect", "tokenized_content": [2, 26497, 10647, 3508, 2722, 2057, 6026, 3, 2180, 1938, 4907, 1007, 4604, 17431, 13339, 4741, 1956, 4010, 4487, 19051, 16, 26497, 10647, 3508, 2722, 2057, 6026, 16, 7533, 8754, 16, 3]}, "items": [{"id": "p_4058", "content": "Hypophosphatemia [SEP] A condition of an abnormally low level of PHOSPHATES in the blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26497, 10647, 3508, 2722, 2057, 6026, 3, 43, 2625, 1927, 1925, 20756, 2330, 2237, 1927, 26473, 1922, 1920, 2877, 18, 3]}]}
{"query": {"id": "q_4059", "content": "glycosuria [SEP] coni syndrome with severe metabolic acidosis, hypophosphatemia, glycosuria, and aminoaciduria. Although tacrolimus was suspected to be the", "tokenized_content": [2, 7533, 8754, 3, 1962, 1033, 4741, 1956, 4010, 4487, 19051, 16, 26497, 10647, 3508, 2722, 2057, 6026, 16, 7533, 8754, 16, 1930, 3835, 29272, 8754, 18, 2876, 21801, 1982, 9407, 3]}, "items": [{"id": "p_4059", "content": "Glycosuria [SEP] The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to H", "score": 1, "type": null, "tokenized_content": [2, 7533, 8754, 3, 1920, 7818, 1927, 1925, 20756, 3103, 4351, 1927, 3817, 1922, 1920, 6960, 16, 2427, 1966, 2253, 2254, 4599, 2786, 19, 3007, 1922, 4440, 18, 2176, 2112, 1998, 2810, 1942, 50, 3]}]}
{"query": {"id": "q_4060", "content": "aminoaciduria [SEP] th severe metabolic acidosis, hypophosphatemia, glycosuria, and aminoaciduria. Although tacrolimus was suspected to be the cause of late post", "tokenized_content": [2, 3835, 29272, 8754, 3, 1913, 4010, 4487, 19051, 16, 26497, 10647, 3508, 2722, 2057, 6026, 16, 7533, 8754, 16, 1930, 3835, 29272, 8754, 18, 2876, 21801, 1982, 9407, 1942, 1998, 3]}, "items": [{"id": "p_4060", "content": "Renal Aminoacidurias [SEP] A group of inherited kidney disorders characterized by the abnormally elevated levels of AMINO ACIDS in URINE. Genetic mutations", "score": 1, "type": null, "tokenized_content": [2, 4604, 3835, 29272, 8754, 1036, 3, 43, 2210, 1927, 12911, 5245, 4414, 4378, 2007, 1920, 20756, 4664, 2428, 1927, 3835, 4576, 1922, 6960, 18, 3299, 3527, 3]}]}
{"query": {"id": "q_4061", "content": "tacrolimus [SEP] osis, hypophosphatemia, glycosuria, and aminoaciduria. Although tacrolimus was suspected to be the cause of late post-transplant renal aci", "tokenized_content": [2, 21801, 3, 3125, 1937, 16, 26497, 10647, 3508, 2722, 2057, 6026, 16, 7533, 8754, 16, 1930, 3835, 29272, 8754, 18, 2876, 21801, 1982, 9407, 1942, 1998, 1920, 3936, 1927, 5058, 3]}, "items": [{"id": "p_4061", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4062", "content": "acidosis [SEP] tion she developed renal Fanconi syndrome with severe metabolic acidosis, hypophosphatemia, glycosuria, and aminoaciduria. Although tacr", "tokenized_content": [2, 19051, 3, 8685, 1916, 4693, 3530, 4604, 17431, 13339, 4741, 1956, 4010, 4487, 19051, 16, 26497, 10647, 3508, 2722, 2057, 6026, 16, 7533, 8754, 16, 1930, 3835, 29272, 8754, 18, 3]}, "items": [{"id": "p_4062", "content": "Acidosis [SEP] A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and me", "score": 1, "type": null, "tokenized_content": [2, 19051, 3, 43, 11896, 2625, 1927, 2687, 4858, 2014, 6882, 1927, 5170, 1922, 1920, 3362, 18, 1920, 2288, 2730, 3584, 2032, 5481, 19051, 1930, 2142, 3]}]}
{"query": {"id": "q_4063", "content": "sirolimus [SEP] ause of late post-transplant renal acidosis and was replaced by sirolimus, acidosis, and electrolyte imbalance got worse. Proximal muscle", "tokenized_content": [2, 4520, 24124, 3, 18238, 1021, 1927, 5058, 2753, 17, 5192, 4604, 19051, 1930, 1982, 8403, 2007, 4520, 24124, 16, 19051, 16, 1930, 15428, 14093, 14643, 9190, 18, 6863, 3760, 3]}, "items": [{"id": "p_4063", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4064", "content": "muscle weakness [SEP] olimus, acidosis, and electrolyte imbalance got worse. Proximal muscle weakness has developed during her follow-up. Fanconi syndrome, as well a", "tokenized_content": [2, 3760, 12175, 3, 2865, 12579, 16, 19051, 16, 1930, 15428, 14093, 14643, 9190, 18, 6863, 3760, 12175, 2258, 3530, 2409, 3656, 2396, 17, 2353, 18, 17431, 13339, 4741, 16, 1966, 3]}, "items": [{"id": "p_4064", "content": "Muscle Weakness [SEP] A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be character", "score": 1, "type": null, "tokenized_content": [2, 3760, 12175, 3, 43, 7715, 2182, 24442, 1927, 26068, 1999, 16, 8656, 16, 2014, 19889, 11081, 1942, 12175, 1927, 3425, 7848, 18, 1920, 12175, 2112, 1998, 2728, 3]}]}
{"query": {"id": "q_4065", "content": "Fanconi syndrome [SEP] r follow-up. Three yr after transplantation she developed renal Fanconi syndrome with severe metabolic acidosis, hypophosphatemia, glycosuria, a", "tokenized_content": [2, 17431, 13339, 4741, 3, 60, 2396, 17, 2353, 18, 2559, 13031, 2256, 6530, 4693, 3530, 4604, 17431, 13339, 4741, 1956, 4010, 4487, 19051, 16, 26497, 10647, 3508, 2722, 2057, 6026, 3]}, "items": [{"id": "p_4065", "content": "Fanconi Syndrome [SEP] A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY", "score": 1, "type": null, "tokenized_content": [2, 17431, 13339, 4741, 3, 43, 16321, 2014, 5815, 2386, 1927, 9612, 5273, 1927, 1920, 6863, 5245, 17946, 2979, 3065, 5668, 1927, 1920, 5245, 3]}]}
{"query": {"id": "q_4066", "content": "myopathy [SEP] as developed during her follow-up. Fanconi syndrome, as well as myopathy, is well recognized in patients with mitochondrial disorders an", "tokenized_content": [2, 25017, 3, 1966, 3530, 2409, 3656, 2396, 17, 2353, 18, 17431, 13339, 4741, 16, 1966, 2486, 1966, 25017, 16, 1977, 2486, 6783, 1922, 2132, 1956, 4596, 4414, 1925, 3]}, "items": [{"id": "p_4066", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_4067", "content": "mitochondrial disorders [SEP] drome, as well as myopathy, is well recognized in patients with mitochondrial disorders and caused by depletion of mtDNA. We suggest that our patient's", "tokenized_content": [2, 4596, 4414, 3, 8442, 3870, 16, 1966, 2486, 1966, 25017, 16, 1977, 2486, 6783, 1922, 2132, 1956, 4596, 4414, 1930, 4189, 2007, 6882, 1927, 11183, 18, 2038, 3220, 1988, 2342, 3]}, "items": [{"id": "p_4067", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_4068", "content": "tubular dysfunction [SEP] and caused by depletion of mtDNA. We suggest that our patient's tubular dysfunction and myopathy may have resulted from mitochondrial dysfunction w", "tokenized_content": [2, 11755, 5273, 3, 1930, 4189, 2007, 6882, 1927, 11183, 18, 2038, 3220, 1988, 2342, 2774, 11, 61, 11755, 5273, 1930, 25017, 2278, 2162, 4306, 2037, 4596, 5273, 65, 3]}, "items": [{"id": "p_4068", "content": "Fanconi Syndrome [SEP] A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY", "score": 1, "type": null, "tokenized_content": [2, 17431, 13339, 4741, 3, 43, 16321, 2014, 5815, 2386, 1927, 9612, 5273, 1927, 1920, 6863, 5245, 17946, 2979, 3065, 5668, 1927, 1920, 5245, 3]}]}
{"query": {"id": "q_4069", "content": "mitochondrial dysfunction [SEP] tient's tubular dysfunction and myopathy may have resulted from mitochondrial dysfunction which is triggered by tacrolimus and augmented by lamivudine.", "tokenized_content": [2, 4596, 5273, 3, 19108, 4905, 11, 61, 11755, 5273, 1930, 25017, 2278, 2162, 4306, 2037, 4596, 5273, 2154, 1977, 9436, 2007, 21801, 1930, 13553, 2007, 30208, 18, 3]}, "items": [{"id": "p_4069", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_4070", "content": "lamivudine [SEP] l dysfunction which is triggered by tacrolimus and augmented by lamivudine.", "tokenized_content": [2, 30208, 3, 54, 5273, 2154, 1977, 9436, 2007, 21801, 1930, 13553, 2007, 30208, 18, 3]}, "items": [{"id": "p_4070", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_4071", "content": "thioperamide [SEP] Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice.", "tokenized_content": [2, 15331, 2116, 5482, 3, 17581, 17, 3189, 5174, 1927, 15331, 2116, 5482, 16, 43, 5328, 8170, 17, 3148, 8151, 1922, 2518, 18, 3]}, "items": [{"id": "p_4071", "content": "thioperamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15331, 2116, 5482, 3, 3]}]}
{"query": {"id": "q_4072", "content": "schizophrenia [SEP] o a role of central histaminergic system in the pathogenesis of schizophrenia. The present study was designed to study the effect of histamin", "tokenized_content": [2, 7899, 3, 57, 43, 2770, 1927, 4101, 14622, 1005, 11545, 2433, 1922, 1920, 6559, 1927, 7899, 18, 1920, 2481, 2161, 1982, 4609, 1942, 2161, 1920, 2495, 1927, 2968, 3717, 3]}, "items": [{"id": "p_4072", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_4073", "content": "histamine [SEP] Experimental and clinical evidence points to a role of central histaminergic system in the pathogenesis of schizophrenia. The present st", "tokenized_content": [2, 14622, 3, 3599, 1930, 2535, 3095, 4273, 1942, 43, 2770, 1927, 4101, 14622, 1005, 11545, 2433, 1922, 1920, 6559, 1927, 7899, 18, 1920, 2481, 1955, 3]}, "items": [{"id": "p_4073", "content": "Histamine [SEP] An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of br", "score": 1, "type": null, "tokenized_content": [2, 14622, 3, 1925, 13610, 3595, 2007, 8145, 22429, 1943, 1927, 13873, 18, 2176, 1977, 43, 9974, 24252, 1927, 6319, 5512, 16, 43, 15595, 2684, 1927, 2387, 3]}]}
{"query": {"id": "q_4074", "content": "catalepsy [SEP] ffect of histamine H(3)-receptor ligands on neuroleptic-induced catalepsy, apomorphine-induced climbing behavior and amphetamine-induced ", "tokenized_content": [2, 4233, 9431, 1012, 3, 10735, 2089, 1927, 14622, 50, 12, 23, 13, 17, 3148, 6908, 1990, 20325, 17920, 17, 2719, 4233, 9431, 1012, 16, 11466, 12492, 11119, 7969, 2912, 17, 3]}, "items": [{"id": "p_4074", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4075", "content": "apomorphine [SEP] stamine H(3)-receptor ligands on neuroleptic-induced catalepsy, apomorphine-induced climbing behavior and amphetamine-induced locomotor act", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 23891, 25157, 50, 12, 23, 13, 17, 3148, 6908, 1990, 20325, 17920, 17, 2719, 4233, 9431, 1012, 16, 11466, 12492, 11119, 7969, 2912, 17, 3]}, "items": [{"id": "p_4075", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_4076", "content": "amphetamine [SEP] ic-induced catalepsy, apomorphine-induced climbing behavior and amphetamine-induced locomotor activities in mice. Catalepsy was induced by ", "tokenized_content": [2, 19057, 3, 3996, 17, 2719, 4233, 9431, 1012, 16, 11466, 12492, 11119, 7969, 2912, 17, 2719, 25449, 3379, 1930, 19057, 17, 2719, 13594, 4209, 1922, 2518, 18, 4233, 9431, 1012, 3]}, "items": [{"id": "p_4076", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_4077", "content": "Catalepsy [SEP]  behavior and amphetamine-induced locomotor activities in mice. Catalepsy was induced by haloperidol (2 mg/kg p.o.), while apomorphine (1", "tokenized_content": [2, 4233, 9431, 1012, 3, 3379, 1930, 19057, 17, 2719, 13594, 4209, 1922, 2518, 18, 4233, 9431, 1012, 1982, 2719, 2007, 25107, 12, 22, 2786, 19, 3621, 58, 18, 57, 18, 3]}, "items": [{"id": "p_4077", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4078", "content": "haloperidol [SEP] -induced locomotor activities in mice. Catalepsy was induced by haloperidol (2 mg/kg p.o.), while apomorphine (1.5 mg/kg s.c.) and amphetam", "tokenized_content": [2, 25107, 3, 17, 2719, 13594, 4209, 1922, 2518, 18, 4233, 9431, 1012, 1982, 2719, 2007, 25107, 12, 22, 2786, 19, 3621, 58, 18, 57, 18, 13, 16, 2679, 11466, 12492, 3]}, "items": [{"id": "p_4078", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_4079", "content": "(R)-alpha-methylhistamine [SEP] dying climbing behavior and locomotor activities, respectively. (R)-alpha-methylhistamine (RAMH) (5 microg i.c.v.) and thioperamide (THP) (15 mg/kg i.p.)", "tokenized_content": [2, 12, 60, 13, 17, 4595, 17, 4963, 17210, 3857, 25157, 3, 17600, 25449, 3379, 1930, 13594, 4209, 16, 2763, 18, 12, 60, 13, 17, 4595, 17, 4963, 17210, 3857, 25157, 3]}, "items": [{"id": "p_4079", "content": "alpha-methylhistamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 4963, 17210, 3857, 25157, 3, 3]}]}
{"query": {"id": "q_4080", "content": "RAMH [SEP]  locomotor activities, respectively. (R)-alpha-methylhistamine (RAMH) (5 microg i.c.v.) and thioperamide (THP) (15 mg/kg i.p.), per ", "tokenized_content": [2, 8221, 1023, 3, 13594, 4209, 16, 2763, 18, 12, 60, 13, 17, 4595, 17, 4963, 17210, 3857, 25157, 12, 8221, 1023, 13, 12, 25, 12517, 51, 18, 45, 18, 64, 3]}, "items": [{"id": "p_4080", "content": "alpha-methylhistamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 4963, 17210, 3857, 25157, 3, 3]}]}
{"query": {"id": "q_4081", "content": "thioperamide [SEP] ctively. (R)-alpha-methylhistamine (RAMH) (5 microg i.c.v.) and thioperamide (THP) (15 mg/kg i.p.), per se did not cause catalepsy. Administ", "tokenized_content": [2, 15331, 2116, 5482, 3, 3369, 5102, 18, 12, 60, 13, 17, 4595, 17, 4963, 17210, 3857, 25157, 12, 8221, 1023, 13, 12, 25, 12517, 51, 18, 45, 18, 64, 18, 3]}, "items": [{"id": "p_4081", "content": "thioperamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15331, 2116, 5482, 3, 3]}]}
{"query": {"id": "q_4082", "content": "THP [SEP] lpha-methylhistamine (RAMH) (5 microg i.c.v.) and thioperamide (THP) (15 mg/kg i.p.), per se did not cause catalepsy. Administratio", "tokenized_content": [2, 15683, 3, 8182, 2722, 17, 4963, 17210, 3857, 25157, 12, 8221, 1023, 13, 12, 25, 12517, 51, 18, 45, 18, 64, 18, 13, 1930, 15331, 2116, 5482, 12, 15683, 13, 3]}, "items": [{"id": "p_4082", "content": "thioperamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15331, 2116, 5482, 3, 3]}]}
{"query": {"id": "q_4083", "content": "hyperactivity [SEP] er se had no effect on these parameters. On amphetamine-induced hyperactivity, THP (3.75 and 7.5 mg/kg i.p.) reduced locomotor time, distance", "tokenized_content": [2, 15534, 3, 2668, 2058, 2430, 2239, 2495, 1990, 2144, 3673, 18, 1990, 19057, 17, 2719, 15534, 16, 15683, 12, 23, 18, 4089, 1930, 27, 18, 25, 2786, 19, 3621, 51, 3]}, "items": [{"id": "p_4083", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_4084", "content": "propafenone [SEP] Transient platypnea-orthodeoxia-like syndrome induced by propafenone overdose in a young woman with Ebstein's anomaly.", "tokenized_content": [2, 5062, 13085, 2290, 3, 6809, 4474, 2085, 9707, 17, 24343, 3695, 15877, 17, 3189, 4741, 2719, 2007, 5062, 13085, 2290, 21090, 1922, 43, 4201, 10440, 1956, 19183, 8037, 11, 61, 3]}, "items": [{"id": "p_4084", "content": "Propafenone [SEP] An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5062, 13085, 2290, 3, 1925, 2246, 23246, 6026, 5899, 1988, 1977, 4443, 3655, 1922, 6493, 16934, 18, 2176, 2222, 2258, 5015, 4666, 17, 7472, 2455, 18, 3]}]}
{"query": {"id": "q_4085", "content": "overdose [SEP] ient platypnea-orthodeoxia-like syndrome induced by propafenone overdose in a young woman with Ebstein's anomaly.", "tokenized_content": [2, 21090, 3, 10116, 4905, 4474, 2085, 9707, 17, 24343, 3695, 15877, 17, 3189, 4741, 2719, 2007, 5062, 13085, 2290, 21090, 1922, 43, 4201, 10440, 1956, 19183, 8037, 11, 61, 20950, 3]}, "items": [{"id": "p_4085", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4086", "content": "Ebstein's anomaly [SEP]  syndrome induced by propafenone overdose in a young woman with Ebstein's anomaly.", "tokenized_content": [2, 19183, 8037, 11, 61, 20950, 3, 4741, 2719, 2007, 5062, 13085, 2290, 21090, 1922, 43, 4201, 10440, 1956, 19183, 8037, 11, 61, 20950, 18, 3]}, "items": [{"id": "p_4086", "content": "Ebstein Anomaly [SEP] A congenital heart defect characterized by downward or apical displacement of the TRICUSPID VALVE, usually with the septal and p", "score": 1, "type": null, "tokenized_content": [2, 19183, 8037, 20950, 3, 43, 9901, 4003, 7374, 4378, 2007, 20130, 2014, 8913, 9514, 1927, 1920, 25487, 9509, 16, 5394, 1956, 1920, 16458, 1930, 58, 3]}]}
{"query": {"id": "q_4087", "content": "Ebstein's anomaly [SEP] s report we describe the case of a 37-year-old white woman with Ebstein's anomaly, who developed a rare syndrome called platypnea-orthodeoxia, ch", "tokenized_content": [2, 19183, 8037, 11, 61, 20950, 3, 61, 3809, 2038, 5993, 1920, 3087, 1927, 43, 3191, 17, 2476, 17, 4156, 4511, 10440, 1956, 19183, 8037, 11, 61, 20950, 16, 2746, 3530, 3]}, "items": [{"id": "p_4087", "content": "Ebstein Anomaly [SEP] A congenital heart defect characterized by downward or apical displacement of the TRICUSPID VALVE, usually with the septal and p", "score": 1, "type": null, "tokenized_content": [2, 19183, 8037, 20950, 3, 43, 9901, 4003, 7374, 4378, 2007, 20130, 2014, 8913, 9514, 1927, 1920, 25487, 9509, 16, 5394, 1956, 1920, 16458, 1930, 58, 3]}]}
{"query": {"id": "q_4088", "content": "hypoxia [SEP] sive right-to-left interatrial shunting with transient profound hypoxia and cyanosis. This shunt of blood via a patent foramen ovale oc", "tokenized_content": [2, 7264, 3, 14398, 1021, 3659, 17, 1942, 17, 3506, 2107, 12078, 2086, 17157, 1941, 1956, 6809, 11098, 7264, 1930, 26898, 8362, 18, 2052, 17157, 1927, 2877, 3454, 43, 16411, 24650, 3]}, "items": [{"id": "p_4088", "content": "Anoxia [SEP] Relatively complete absence of oxygen in one or more tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28976, 18068, 1019, 3, 4322, 4080, 3905, 1927, 4612, 1922, 2340, 2014, 2253, 3878, 18, 3]}]}
{"query": {"id": "q_4089", "content": "cyanosis [SEP] o-left interatrial shunting with transient profound hypoxia and cyanosis. This shunt of blood via a patent foramen ovale occurred in the", "tokenized_content": [2, 26898, 8362, 3, 57, 17, 3506, 2107, 12078, 2086, 17157, 1941, 1956, 6809, 11098, 7264, 1930, 26898, 8362, 18, 2052, 17157, 1927, 2877, 3454, 43, 16411, 24650, 22584, 1021, 4807, 3]}, "items": [{"id": "p_4089", "content": "Cyanosis [SEP] A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin ", "score": 1, "type": null, "tokenized_content": [2, 26898, 8362, 3, 43, 2266, 15641, 2014, 25945, 2951, 2863, 18778, 1943, 1927, 1920, 4407, 1930, 27103, 5726, 2810, 1942, 1925, 2760, 1922, 1920, 4351, 1927, 16333, 2432, 1981, 9652, 3]}]}
{"query": {"id": "q_4090", "content": "patent foramen ovale [SEP] nsient profound hypoxia and cyanosis. This shunt of blood via a patent foramen ovale occurred in the presence of a normal pulmonary artery pressure,", "tokenized_content": [2, 16411, 24650, 22584, 1021, 3, 4246, 3660, 11098, 7264, 1930, 26898, 8362, 18, 2052, 17157, 1927, 2877, 3454, 43, 16411, 24650, 22584, 1021, 4807, 1922, 1920, 2990, 1927, 43, 2791, 3]}, "items": [{"id": "p_4090", "content": "Foramen Ovale, Patent [SEP] A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communi", "score": 1, "type": null, "tokenized_content": [2, 24650, 22584, 1021, 16, 16411, 3, 43, 2625, 1922, 2154, 1920, 24650, 22584, 1021, 1922, 1920, 9224, 17026, 16300, 1942, 5428, 17002, 2256, 5043, 18, 2052, 2274, 1922, 4552, 3352, 1033, 3]}]}
{"query": {"id": "q_4091", "content": "propafenone [SEP] l pulmonary artery pressure, and was probably precipitated by a propafenone overdose. This drug caused biventricular dysfunction, due to it", "tokenized_content": [2, 5062, 13085, 2290, 3, 54, 5352, 5511, 3772, 16, 1930, 1982, 6226, 14019, 2007, 43, 5062, 13085, 2290, 21090, 18, 2052, 2838, 4189, 27535, 11817, 5273, 16, 2810, 1942, 2176, 3]}, "items": [{"id": "p_4091", "content": "Propafenone [SEP] An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5062, 13085, 2290, 3, 1925, 2246, 23246, 6026, 5899, 1988, 1977, 4443, 3655, 1922, 6493, 16934, 18, 2176, 2222, 2258, 5015, 4666, 17, 7472, 2455, 18, 3]}]}
{"query": {"id": "q_4092", "content": "overdose [SEP] artery pressure, and was probably precipitated by a propafenone overdose. This drug caused biventricular dysfunction, due to its negativ", "tokenized_content": [2, 21090, 3, 5511, 3772, 16, 1930, 1982, 6226, 14019, 2007, 43, 5062, 13085, 2290, 21090, 18, 2052, 2838, 4189, 27535, 11817, 5273, 16, 2810, 1942, 2496, 2922, 1968, 1020, 3]}, "items": [{"id": "p_4092", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4093", "content": "biventricular dysfunction [SEP] obably precipitated by a propafenone overdose. This drug caused biventricular dysfunction, due to its negative inotropic effect, and hypotension, due to ", "tokenized_content": [2, 27535, 11817, 5273, 3, 2384, 3458, 14019, 2007, 43, 5062, 13085, 2290, 21090, 18, 2052, 2838, 4189, 27535, 11817, 5273, 16, 2810, 1942, 2496, 3136, 28853, 2495, 16, 1930, 16453, 3]}, "items": [{"id": "p_4093", "content": "Ventricular Dysfunction [SEP] A condition in which HEART VENTRICLES exhibit impaired function.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6493, 5273, 3, 43, 2625, 1922, 2154, 4003, 21008, 5987, 5761, 2347, 18, 3]}]}
{"query": {"id": "q_4094", "content": "hypotension [SEP] tricular dysfunction, due to its negative inotropic effect, and hypotension, due to its peripheral vasodilatory effect. These effects gave ", "tokenized_content": [2, 16453, 3, 12258, 2168, 5273, 16, 2810, 1942, 2496, 3136, 28853, 2495, 16, 1930, 16453, 16, 2810, 1942, 2496, 5009, 28194, 1012, 2495, 18, 2144, 2564, 7981, 3]}, "items": [{"id": "p_4094", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4095", "content": "cisplatin [SEP] A Phase II trial of cisplatin plus WR-2721 (amifostine) for metastatic breast carcinoma: an E", "tokenized_content": [2, 9284, 3, 43, 3193, 2890, 3046, 1927, 9284, 5390, 4573, 17, 22785, 1009, 12, 15665, 15282, 2156, 2053, 13, 1958, 6476, 3739, 5373, 30, 1925, 47, 3]}, "items": [{"id": "p_4095", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_4096", "content": "WR-2721 [SEP] A Phase II trial of cisplatin plus WR-2721 (amifostine) for metastatic breast carcinoma: an Eastern Cooper", "tokenized_content": [2, 4573, 17, 22785, 1009, 3, 43, 3193, 2890, 3046, 1927, 9284, 5390, 4573, 17, 22785, 1009, 12, 15665, 15282, 2156, 2053, 13, 1958, 6476, 3739, 5373, 30, 1925, 11562, 9108, 3]}, "items": [{"id": "p_4096", "content": "Amifostine [SEP] A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.\n   ", "score": 1, "type": null, "tokenized_content": [2, 15665, 15282, 2156, 2053, 3, 43, 3421, 17809, 25120, 4211, 1966, 43, 5442, 17, 6337, 5899, 18, 2176, 5092, 13881, 21742, 1930, 2278, 3367, 13725, 13086, 18, 3]}]}
{"query": {"id": "q_4097", "content": "amifostine [SEP] A Phase II trial of cisplatin plus WR-2721 (amifostine) for metastatic breast carcinoma: an Eastern Cooperative Oncolo", "tokenized_content": [2, 15665, 15282, 2156, 2053, 3, 43, 3193, 2890, 3046, 1927, 9284, 5390, 4573, 17, 22785, 1009, 12, 15665, 15282, 2156, 2053, 13, 1958, 6476, 3739, 5373, 30, 1925, 11562, 13350, 3]}, "items": [{"id": "p_4097", "content": "Amifostine [SEP] A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.\n   ", "score": 1, "type": null, "tokenized_content": [2, 15665, 15282, 2156, 2053, 3, 43, 3421, 17809, 25120, 4211, 1966, 43, 5442, 17, 6337, 5899, 18, 2176, 5092, 13881, 21742, 1930, 2278, 3367, 13725, 13086, 18, 3]}]}
{"query": {"id": "q_4098", "content": "breast carcinoma [SEP]  II trial of cisplatin plus WR-2721 (amifostine) for metastatic breast carcinoma: an Eastern Cooperative Oncology Group Study (E8188).", "tokenized_content": [2, 3739, 5373, 3, 2890, 3046, 1927, 9284, 5390, 4573, 17, 22785, 1009, 12, 15665, 15282, 2156, 2053, 13, 1958, 6476, 3739, 5373, 30, 1925, 11562, 13350, 11605, 2210, 2161, 12, 3]}, "items": [{"id": "p_4098", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_4099", "content": "Cisplatin [SEP] BACKGROUND: Cisplatin has minimal antitumor activity when used as second- or third-li", "tokenized_content": [2, 9284, 3, 3872, 30, 9284, 2258, 6343, 11775, 2455, 2469, 2251, 1966, 2812, 17, 2014, 4563, 17, 2336, 3]}, "items": [{"id": "p_4099", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_4100", "content": "breast carcinoma [SEP] vity when used as second- or third-line treatment of metastatic breast carcinoma. Older reports suggest an objective response rate of 8% when 60", "tokenized_content": [2, 3739, 5373, 3, 5208, 1012, 2469, 2251, 1966, 2812, 17, 2014, 4563, 17, 2823, 2311, 1927, 6476, 3739, 5373, 18, 4706, 4710, 3220, 1925, 4470, 2644, 2769, 1927, 28, 9, 3]}, "items": [{"id": "p_4100", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_4101", "content": "cisplatin [SEP] s suggest an objective response rate of 8% when 60-120 mg/m2 of cisplatin is administered every 3-4 weeks. Although a dose-response effec", "tokenized_content": [2, 9284, 3, 61, 3220, 1925, 4470, 2644, 2769, 1927, 28, 9, 2469, 3276, 17, 6103, 2786, 19, 6056, 1927, 9284, 1977, 5254, 4808, 23, 17, 24, 3625, 18, 2876, 43, 3]}, "items": [{"id": "p_4101", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_4102", "content": "toxicities [SEP] onse effect has been observed with cisplatin, the dose-limiting toxicities associated with cisplatin (e.g., nephrotoxicity, ototoxicity, a", "tokenized_content": [2, 15251, 3, 24335, 1021, 2495, 2258, 2252, 2528, 1956, 9284, 16, 1920, 3253, 17, 8051, 15251, 2458, 1956, 9284, 12, 47, 18, 49, 18, 16, 27880, 16, 7608, 11930, 16, 3]}, "items": [{"id": "p_4102", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4103", "content": "nephrotoxicity [SEP] , the dose-limiting toxicities associated with cisplatin (e.g., nephrotoxicity, ototoxicity, and neurotoxicity) have limited its use as a trea", "tokenized_content": [2, 27880, 3, 16, 1920, 3253, 17, 8051, 15251, 2458, 1956, 9284, 12, 47, 18, 49, 18, 16, 27880, 16, 7608, 11930, 16, 1930, 18034, 13, 2162, 3892, 2496, 2485, 1966, 3]}, "items": [{"id": "p_4103", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4104", "content": "ototoxicity [SEP] ing toxicities associated with cisplatin (e.g., nephrotoxicity, ototoxicity, and neurotoxicity) have limited its use as a treatment for bre", "tokenized_content": [2, 7608, 11930, 3, 30393, 15251, 2458, 1956, 9284, 12, 47, 18, 49, 18, 16, 27880, 16, 7608, 11930, 16, 1930, 18034, 13, 2162, 3892, 2496, 2485, 1966, 43, 2311, 1958, 3]}, "items": [{"id": "p_4104", "content": "Hearing Disorders [SEP] Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices,", "score": 1, "type": null, "tokenized_content": [2, 8512, 4414, 3, 2961, 1988, 3960, 1920, 5303, 1927, 8401, 21896, 1036, 1930, 2988, 2037, 1920, 2237, 1927, 1920, 4352, 1942, 1920, 5338, 18220, 16, 3]}]}
{"query": {"id": "q_4105", "content": "neurotoxicity [SEP] sociated with cisplatin (e.g., nephrotoxicity, ototoxicity, and neurotoxicity) have limited its use as a treatment for breast carcinoma. WR-2", "tokenized_content": [2, 18034, 3, 4744, 1981, 1956, 9284, 12, 47, 18, 49, 18, 16, 27880, 16, 7608, 11930, 16, 1930, 18034, 13, 2162, 3892, 2496, 2485, 1966, 43, 2311, 1958, 3739, 5373, 3]}, "items": [{"id": "p_4105", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4106", "content": "WR-2721 [SEP] city) have limited its use as a treatment for breast carcinoma. WR-2721 or amifostine initially was developed to protect military perso", "tokenized_content": [2, 4573, 17, 22785, 1009, 3, 8318, 13, 2162, 3892, 2496, 2485, 1966, 43, 2311, 1958, 3739, 5373, 18, 4573, 17, 22785, 1009, 2014, 15665, 15282, 2156, 2053, 6370, 1982, 3530, 3]}, "items": [{"id": "p_4106", "content": "Amifostine [SEP] A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.\n   ", "score": 1, "type": null, "tokenized_content": [2, 15665, 15282, 2156, 2053, 3, 43, 3421, 17809, 25120, 4211, 1966, 43, 5442, 17, 6337, 5899, 18, 2176, 5092, 13881, 21742, 1930, 2278, 3367, 13725, 13086, 18, 3]}]}
{"query": {"id": "q_4107", "content": "amifostine [SEP] limited its use as a treatment for breast carcinoma. WR-2721 or amifostine initially was developed to protect military personnel in the ev", "tokenized_content": [2, 15665, 15282, 2156, 2053, 3, 3892, 2496, 2485, 1966, 43, 2311, 1958, 3739, 5373, 18, 4573, 17, 22785, 1009, 2014, 15665, 15282, 2156, 2053, 6370, 1982, 3530, 1942, 9145, 15720, 3]}, "items": [{"id": "p_4107", "content": "Amifostine [SEP] A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.\n   ", "score": 1, "type": null, "tokenized_content": [2, 15665, 15282, 2156, 2053, 3, 43, 3421, 17809, 25120, 4211, 1966, 43, 5442, 17, 6337, 5899, 18, 2176, 5092, 13881, 21742, 1930, 2278, 3367, 13725, 13086, 18, 3]}]}
{"query": {"id": "q_4108", "content": "Amifostine [SEP] oped to protect military personnel in the event of nuclear war. Amifostine subsequently was shown to protect normal tissues from the toxic", "tokenized_content": [2, 15665, 15282, 2156, 2053, 3, 2494, 1919, 1942, 9145, 15720, 12811, 1922, 1920, 4817, 1927, 4254, 8200, 18, 15665, 15282, 2156, 2053, 5326, 1982, 2522, 1942, 9145, 2791, 3878, 2037, 3]}, "items": [{"id": "p_4108", "content": "Amifostine [SEP] A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.\n   ", "score": 1, "type": null, "tokenized_content": [2, 15665, 15282, 2156, 2053, 3, 43, 3421, 17809, 25120, 4211, 1966, 43, 5442, 17, 6337, 5899, 18, 2176, 5092, 13881, 21742, 1930, 2278, 3367, 13725, 13086, 18, 3]}]}
{"query": {"id": "q_4109", "content": "alkylating agents [SEP] y was shown to protect normal tissues from the toxic effects of alkylating agents and cisplatin without decreasing the antitumor effect of the ch", "tokenized_content": [2, 28912, 4820, 3, 67, 1982, 2522, 1942, 9145, 2791, 3878, 2037, 1920, 6161, 2564, 1927, 28912, 4820, 1930, 9284, 2979, 7742, 1920, 11775, 2495, 1927, 1920, 2016, 3]}, "items": [{"id": "p_4109", "content": "Alkylating Agents [SEP] Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper func", "score": 1, "type": null, "tokenized_content": [2, 28912, 4820, 3, 3626, 6079, 10164, 1988, 11959, 13345, 12467, 2460, 12186, 3500, 4206, 1930, 6113, 4625, 2310, 3405, 2277, 1030, 3]}]}
{"query": {"id": "q_4110", "content": "neuropathy [SEP]  severity of cisplatin-induced nephrotoxicity, ototoxicity, and neuropathy were reduced. METHODS: A Phase II study of the combination of c", "tokenized_content": [2, 13177, 3, 5155, 1927, 9284, 17, 2719, 27880, 16, 7608, 11930, 16, 1930, 13177, 1985, 3028, 18, 2860, 30, 43, 3193, 2890, 2161, 1927, 1920, 3921, 1927, 45, 3]}, "items": [{"id": "p_4110", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4111", "content": "mannitol [SEP] /m2 was administered over 30 minutes. Intravenous hydration and mannitol was administered before and after cisplatin. Treatment was admi", "tokenized_content": [2, 20915, 3, 19, 6056, 1982, 5254, 2338, 2627, 4814, 18, 7307, 16561, 1930, 20915, 1982, 5254, 3119, 1930, 2256, 9284, 18, 2311, 1982, 3034, 1033, 3]}, "items": [{"id": "p_4111", "content": "Mannitol [SEP] A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from", "score": 1, "type": null, "tokenized_content": [2, 20915, 3, 43, 26829, 1930, 4604, 4785, 8379, 2712, 1942, 26297, 18, 2176, 2258, 5082, 2228, 3844, 3113, 1966, 2176, 1977, 6318, 11412, 2037, 3]}]}
{"query": {"id": "q_4112", "content": "Neurologic toxicity [SEP] atients (57%) stopped treatment because of disease progression. Neurologic toxicity was reported in 52% of patients. Seven different life-threateni", "tokenized_content": [2, 14314, 5532, 3, 2019, 6746, 12, 4786, 9, 13, 12032, 2311, 2882, 1927, 2573, 4380, 18, 14314, 5532, 1982, 2568, 1922, 4764, 9, 1927, 2132, 18, 5260, 2413, 3308, 17, 3]}, "items": [{"id": "p_4112", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4113", "content": "tumor [SEP] BACKGROUND: Cisplatin has minimal antitumor activity when used as second- or third-line treatment of metast", "tokenized_content": [2, 2798, 3, 3872, 30, 9284, 2258, 6343, 11775, 2455, 2469, 2251, 1966, 2812, 17, 2014, 4563, 17, 2823, 2311, 1927, 4025, 3]}, "items": [{"id": "p_4113", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4114", "content": "toxicity [SEP] dose-limiting toxicities associated with cisplatin (e.g., nephrotoxicity, ototoxicity, and neurotoxicity) have limited its use as a trea", "tokenized_content": [2, 5532, 3, 3253, 17, 8051, 15251, 2458, 1956, 9284, 12, 47, 18, 49, 18, 16, 27880, 16, 7608, 11930, 16, 1930, 18034, 13, 2162, 3892, 2496, 2485, 1966, 43, 2171, 3]}, "items": [{"id": "p_4114", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4115", "content": "Warfarin [SEP] Warfarin-induced iliopsoas hemorrhage with subsequent femoral nerve pals", "tokenized_content": [2, 16170, 3, 16170, 17, 2719, 14872, 4001, 6952, 1036, 10489, 1956, 4521, 9550, 5507, 16834, 3]}, "items": [{"id": "p_4115", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_4116", "content": "hemorrhage [SEP] Warfarin-induced iliopsoas hemorrhage with subsequent femoral nerve palsy.", "tokenized_content": [2, 10489, 3, 16170, 17, 2719, 14872, 4001, 6952, 1036, 10489, 1956, 4521, 9550, 5507, 18698, 18, 3]}, "items": [{"id": "p_4116", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_4117", "content": "femoral nerve palsy [SEP] Warfarin-induced iliopsoas hemorrhage with subsequent femoral nerve palsy.", "tokenized_content": [2, 9550, 5507, 18698, 3, 16170, 17, 2719, 14872, 4001, 6952, 1036, 10489, 1956, 4521, 9550, 5507, 18698, 18, 3]}, "items": [{"id": "p_4117", "content": "Femoral Neuropathy [SEP] Disease involving the femoral nerve. The femoral nerve may be injured by ISCHEMIA (e.g., in association with DIABETIC NEUROPATHI", "score": 1, "type": null, "tokenized_content": [2, 9550, 13177, 3, 2573, 5884, 1920, 9550, 5507, 18, 1920, 9550, 5507, 2278, 1998, 11292, 2007, 7716, 12, 47, 18, 49, 18, 16, 1922, 3279, 1956, 6152, 8798, 1033, 3]}]}
{"query": {"id": "q_4118", "content": "warfarin [SEP] We present the case of a 28-year-old man on chronic warfarin therapy who sustained a minor muscle tear and developed increas", "tokenized_content": [2, 16170, 3, 2038, 2481, 1920, 3087, 1927, 43, 3158, 17, 2476, 17, 4156, 2323, 1990, 3724, 16170, 3181, 2746, 7637, 43, 5857, 3760, 12650, 1930, 3530, 2203, 1934, 3]}, "items": [{"id": "p_4118", "content": "Warfarin [SEP] An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the", "score": 1, "type": null, "tokenized_content": [2, 16170, 3, 1925, 18509, 1988, 8016, 2007, 7918, 1920, 4271, 1927, 6111, 53, 17, 3100, 12441, 2790, 18, 16170, 1977, 3391, 1958, 1920, 3]}]}
{"query": {"id": "q_4119", "content": "muscle tear [SEP] -year-old man on chronic warfarin therapy who sustained a minor muscle tear and developed increasing pain and a flexure contracture of the ", "tokenized_content": [2, 3760, 12650, 3, 17, 2476, 17, 4156, 2323, 1990, 3724, 16170, 3181, 2746, 7637, 43, 5857, 3760, 12650, 1930, 3530, 3605, 3594, 1930, 43, 5795, 2027, 14456, 2027, 1927, 1920, 3]}, "items": [{"id": "p_4119", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_4120", "content": "pain [SEP] rapy who sustained a minor muscle tear and developed increasing pain and a flexure contracture of the right hip. Surgical exploratio", "tokenized_content": [2, 3594, 3, 3694, 1012, 2746, 7637, 43, 5857, 3760, 12650, 1930, 3530, 3605, 3594, 1930, 43, 5795, 2027, 14456, 2027, 1927, 1920, 3659, 7679, 18, 4548, 11596, 1968, 1037, 3]}, "items": [{"id": "p_4120", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4121", "content": "contracture [SEP] a minor muscle tear and developed increasing pain and a flexure contracture of the right hip. Surgical exploration revealed an iliopsoas he", "tokenized_content": [2, 14456, 2027, 3, 43, 5857, 3760, 12650, 1930, 3530, 3605, 3594, 1930, 43, 5795, 2027, 14456, 2027, 1927, 1920, 3659, 7679, 18, 4548, 11557, 3404, 1925, 14872, 4001, 6952, 1036, 3]}, "items": [{"id": "p_4121", "content": "Contracture [SEP] Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14456, 2027, 3, 7171, 14177, 1927, 1920, 3760, 2014, 2303, 3793, 2960, 4760, 43, 6047, 16, 8444, 5829, 1927, 1920, 6047, 18, 3]}]}
{"query": {"id": "q_4122", "content": "hematoma [SEP] re of the right hip. Surgical exploration revealed an iliopsoas hematoma and femoral nerve entrapment, resulting in a femoral nerve pals", "tokenized_content": [2, 18984, 3, 1964, 1927, 1920, 3659, 7679, 18, 4548, 11557, 3404, 1925, 14872, 4001, 6952, 1036, 18984, 1930, 9550, 5507, 29057, 16, 3864, 1922, 43, 9550, 5507, 16834, 3]}, "items": [{"id": "p_4122", "content": "Hematoma [SEP] A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18984, 3, 43, 4957, 1927, 2877, 7008, 1920, 2877, 7208, 18, 18984, 2112, 1998, 6579, 1922, 1925, 3090, 16, 5230, 16, 2014, 2960, 18, 3]}]}
{"query": {"id": "q_4123", "content": "nerve entrapment [SEP] Surgical exploration revealed an iliopsoas hematoma and femoral nerve entrapment, resulting in a femoral nerve palsy and partial loss of quadric", "tokenized_content": [2, 5507, 29057, 3, 4548, 11557, 3404, 1925, 14872, 4001, 6952, 1036, 18984, 1930, 9550, 5507, 29057, 16, 3864, 1922, 43, 9550, 5507, 18698, 1930, 5740, 3257, 1927, 22464, 3]}, "items": [{"id": "p_4123", "content": "Nerve Compression Syndromes [SEP] Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerv", "score": 1, "type": null, "tokenized_content": [2, 5507, 10399, 12688, 3, 5821, 10399, 1927, 12014, 2014, 5507, 9398, 2037, 4495, 2014, 5771, 5092, 18, 2144, 2278, 3211, 1922, 43, 12382, 3367, 1942, 7342, 3]}]}
{"query": {"id": "q_4124", "content": "femoral nerve palsy [SEP] iliopsoas hematoma and femoral nerve entrapment, resulting in a femoral nerve palsy and partial loss of quadriceps functions. Anticoagulant-induced", "tokenized_content": [2, 9550, 5507, 18698, 3, 14872, 4001, 6952, 1036, 18984, 1930, 9550, 5507, 29057, 16, 3864, 1922, 43, 9550, 5507, 18698, 1930, 5740, 3257, 1927, 23133, 4088, 18, 18509, 17, 2719, 3]}, "items": [{"id": "p_4124", "content": "Femoral Neuropathy [SEP] Disease involving the femoral nerve. The femoral nerve may be injured by ISCHEMIA (e.g., in association with DIABETIC NEUROPATHI", "score": 1, "type": null, "tokenized_content": [2, 9550, 13177, 3, 2573, 5884, 1920, 9550, 5507, 18, 1920, 9550, 5507, 2278, 1998, 11292, 2007, 7716, 12, 47, 18, 49, 18, 16, 1922, 3279, 1956, 6152, 8798, 1033, 3]}]}
{"query": {"id": "q_4125", "content": "partial loss of quadriceps functions [SEP] emoral nerve entrapment, resulting in a femoral nerve palsy and partial loss of quadriceps functions. Anticoagulant-induced femoral nerve palsy represents the most ", "tokenized_content": [2, 5740, 3257, 1927, 23133, 4088, 3, 5138, 7317, 5507, 29057, 16, 3864, 1922, 43, 9550, 5507, 18698, 1930, 5740, 3257, 1927, 23133, 4088, 18, 18509, 17, 2719, 9550, 5507, 18698, 3]}, "items": [{"id": "p_4125", "content": "Muscular Diseases [SEP] Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12330, 3902, 3, 5815, 16, 11444, 16, 1930, 9901, 4414, 1927, 7345, 3760, 1930, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_4126", "content": "peripheral neuropathy [SEP] nerve palsy represents the most common form of warfarin-induced peripheral neuropathy; it is characterized by severe pain in the inguinal region, var", "tokenized_content": [2, 5009, 13177, 3, 5507, 18698, 4972, 1920, 2501, 3059, 2386, 1927, 16170, 17, 2719, 5009, 13177, 31, 2176, 1977, 4378, 2007, 4010, 3594, 1922, 1920, 19820, 3031, 16, 4953, 3]}, "items": [{"id": "p_4126", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_4127", "content": "motor and sensory impairment [SEP] rized by severe pain in the inguinal region, varying degrees of motor and sensory impairment, and flexure contracture of the involved extremity.", "tokenized_content": [2, 4842, 1930, 6893, 6159, 3, 11280, 6756, 2007, 4010, 3594, 1922, 1920, 19820, 3031, 16, 7155, 6429, 1927, 4842, 1930, 6893, 6159, 16, 1930, 5795, 2027, 14456, 2027, 1927, 1920, 3]}, "items": [{"id": "p_4127", "content": "Hereditary Sensory and Motor Neuropathy [SEP] A group of slowly progressive inherited disorders affecting motor and sensory peripheral nerves. Subtypes include HMSNs I-VII. H", "score": 1, "type": null, "tokenized_content": [2, 16321, 6893, 1930, 4842, 13177, 3, 43, 2210, 1927, 11240, 7529, 12911, 4414, 7359, 4842, 1930, 6893, 5009, 12014, 18, 8160, 3951, 21904, 3355, 51, 17, 16852, 18, 50, 3]}]}
{"query": {"id": "q_4128", "content": "Myasthenia gravis [SEP] Myasthenia gravis caused by penicillamine and chloroquine therapy for rheumatoid ", "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 3057, 27618, 8572, 12413, 1937, 4189, 2007, 25142, 3812, 1930, 20813, 3181, 1958, 13053, 3]}, "items": [{"id": "p_4128", "content": "Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai", "score": 1, "type": null, "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 43, 4770, 1927, 15829, 5303, 4378, 2007, 12175, 1927, 13598, 1930, 7345, 7848, 18, 15510, 6554, 8770, 1033, 3]}]}
{"query": {"id": "q_4129", "content": "penicillamine [SEP] Myasthenia gravis caused by penicillamine and chloroquine therapy for rheumatoid arthritis.", "tokenized_content": [2, 25142, 3812, 3, 3057, 27618, 8572, 12413, 1937, 4189, 2007, 25142, 3812, 1930, 20813, 3181, 1958, 13053, 8884, 18, 3]}, "items": [{"id": "p_4129", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_4130", "content": "chloroquine [SEP] Myasthenia gravis caused by penicillamine and chloroquine therapy for rheumatoid arthritis.", "tokenized_content": [2, 20813, 3, 3057, 27618, 8572, 12413, 1937, 4189, 2007, 25142, 3812, 1930, 20813, 3181, 1958, 13053, 8884, 18, 3]}, "items": [{"id": "p_4130", "content": "Chloroquine [SEP] The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arth", "score": 1, "type": null, "tokenized_content": [2, 20813, 3, 1920, 29183, 27290, 5899, 1956, 43, 2856, 1988, 1977, 2084, 2486, 7372, 18, 2176, 2258, 2222, 2252, 2251, 1942, 2297, 13053, 9273, 3]}]}
{"query": {"id": "q_4131", "content": "rheumatoid arthritis [SEP] enia gravis caused by penicillamine and chloroquine therapy for rheumatoid arthritis.", "tokenized_content": [2, 13053, 8884, 3, 2066, 2126, 12413, 1937, 4189, 2007, 25142, 3812, 1930, 20813, 3181, 1958, 13053, 8884, 18, 3]}, "items": [{"id": "p_4131", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_4132", "content": "myasthenia gravis [SEP]  described a unique patient who had reversible and dose-related myasthenia gravis after penicillamine and chloroquine therapy for rheumatoid arth", "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 2910, 43, 5008, 2774, 2746, 2430, 10743, 1930, 3253, 17, 2712, 3057, 27618, 8572, 12413, 1937, 2256, 25142, 3812, 1930, 20813, 3181, 1958, 13053, 3]}, "items": [{"id": "p_4132", "content": "Myasthenia Gravis [SEP] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed agai", "score": 1, "type": null, "tokenized_content": [2, 3057, 27618, 8572, 12413, 1937, 3, 43, 4770, 1927, 15829, 5303, 4378, 2007, 12175, 1927, 13598, 1930, 7345, 7848, 18, 15510, 6554, 8770, 1033, 3]}]}
{"query": {"id": "q_4133", "content": "penicillamine [SEP] ent who had reversible and dose-related myasthenia gravis after penicillamine and chloroquine therapy for rheumatoid arthritis. Although acet", "tokenized_content": [2, 25142, 3812, 3, 8496, 2746, 2430, 10743, 1930, 3253, 17, 2712, 3057, 27618, 8572, 12413, 1937, 2256, 25142, 3812, 1930, 20813, 3181, 1958, 13053, 8884, 18, 2876, 4118, 3]}, "items": [{"id": "p_4133", "content": "Penicillamine [SEP] 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic a", "score": 1, "type": null, "tokenized_content": [2, 25142, 3812, 3, 23, 17, 17275, 17, 46, 17, 21884, 18, 1920, 2501, 6293, 4877, 4863, 1927, 1920, 9957, 7560, 18, 2176, 1977, 2251, 1966, 1925, 2246, 5004, 3708, 16418, 43, 3]}]}
{"query": {"id": "q_4134", "content": "chloroquine [SEP] ible and dose-related myasthenia gravis after penicillamine and chloroquine therapy for rheumatoid arthritis. Although acetylcholine recept", "tokenized_content": [2, 20813, 3, 6180, 1952, 1930, 3253, 17, 2712, 3057, 27618, 8572, 12413, 1937, 2256, 25142, 3812, 1930, 20813, 3181, 1958, 13053, 8884, 18, 2876, 14561, 2793, 1031, 3]}, "items": [{"id": "p_4134", "content": "Chloroquine [SEP] The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arth", "score": 1, "type": null, "tokenized_content": [2, 20813, 3, 1920, 29183, 27290, 5899, 1956, 43, 2856, 1988, 1977, 2084, 2486, 7372, 18, 2176, 2258, 2222, 2252, 2251, 1942, 2297, 13053, 9273, 3]}]}
{"query": {"id": "q_4135", "content": "rheumatoid arthritis [SEP] asthenia gravis after penicillamine and chloroquine therapy for rheumatoid arthritis. Although acetylcholine receptor antibodies were not detectable", "tokenized_content": [2, 13053, 8884, 3, 6187, 8572, 12413, 1937, 2256, 25142, 3812, 1930, 20813, 3181, 1958, 13053, 8884, 18, 2876, 14561, 3148, 3788, 1985, 2084, 7398, 3]}, "items": [{"id": "p_4135", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_4136", "content": "acetylcholine [SEP] mine and chloroquine therapy for rheumatoid arthritis. Although acetylcholine receptor antibodies were not detectable, the time course was co", "tokenized_content": [2, 14561, 3, 24165, 1930, 20813, 3181, 1958, 13053, 8884, 18, 2876, 14561, 3148, 3788, 1985, 2084, 7398, 16, 1920, 2367, 4914, 1982, 2081, 3]}, "items": [{"id": "p_4136", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_4137", "content": "Nephrotoxicity [SEP] Nephrotoxicity of combined cephalothin-gentamicin regimen.", "tokenized_content": [2, 27880, 3, 27880, 1927, 4252, 15221, 17809, 1022, 17, 17144, 8607, 18, 3]}, "items": [{"id": "p_4137", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4138", "content": "cephalothin [SEP] Nephrotoxicity of combined cephalothin-gentamicin regimen.", "tokenized_content": [2, 15221, 17809, 1022, 3, 27880, 1927, 4252, 15221, 17809, 1022, 17, 17144, 8607, 18, 3]}, "items": [{"id": "p_4138", "content": "Cephalothin [SEP] A cephalosporin antibiotic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15221, 17809, 1022, 3, 43, 25091, 1921, 7267, 18, 3]}]}
{"query": {"id": "q_4139", "content": "gentamicin [SEP] Nephrotoxicity of combined cephalothin-gentamicin regimen.", "tokenized_content": [2, 17144, 3, 27880, 1927, 4252, 15221, 17809, 1022, 17, 17144, 8607, 18, 3]}, "items": [{"id": "p_4139", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_4140", "content": "acute tubular necrosis [SEP] Two patients developed acute tubular necrosis, characterized clinically by acute oliguric renal failure, whil", "tokenized_content": [2, 3939, 11755, 7476, 3, 2288, 2132, 3530, 3939, 11755, 7476, 16, 4378, 5908, 2007, 3939, 4833, 15861, 4604, 4574, 16, 2003, 1970, 3]}, "items": [{"id": "p_4140", "content": "Kidney Tubular Necrosis, Acute [SEP] Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure", "score": 1, "type": null, "tokenized_content": [2, 5245, 11755, 7476, 16, 3939, 3, 3939, 5245, 4574, 3864, 2037, 12102, 1927, 4944, 2094, 1927, 1920, 5245, 14876, 18, 2176, 1977, 5384, 6898, 1942, 3395, 3]}]}
{"query": {"id": "q_4141", "content": "oliguric [SEP] loped acute tubular necrosis, characterized clinically by acute oliguric renal failure, while they were receiving a combination of cepha", "tokenized_content": [2, 4833, 15861, 3, 24910, 1007, 3939, 11755, 7476, 16, 4378, 5908, 2007, 3939, 4833, 15861, 4604, 4574, 16, 2679, 2611, 1985, 5962, 43, 3921, 1927, 17008, 2722, 3]}, "items": [{"id": "p_4141", "content": "Oliguria [SEP] Decreased URINE output that is below the normal range. Oliguria can be defined as urine output of less than or equal to 0.5 or 1", "score": 1, "type": null, "tokenized_content": [2, 4833, 8754, 3, 3261, 6960, 6647, 1988, 1977, 4535, 1920, 2791, 3109, 18, 4833, 8754, 2112, 1998, 3608, 1966, 6960, 6647, 1927, 2941, 2254, 2014, 5557, 1942, 20, 18, 25, 2014, 21, 3]}]}
{"query": {"id": "q_4142", "content": "renal failure [SEP] te tubular necrosis, characterized clinically by acute oliguric renal failure, while they were receiving a combination of cephalothin sodium ", "tokenized_content": [2, 4604, 4574, 3, 3602, 11755, 7476, 16, 4378, 5908, 2007, 3939, 4833, 15861, 4604, 4574, 16, 2679, 2611, 1985, 5962, 43, 3921, 1927, 15221, 17809, 1022, 5227, 3]}, "items": [{"id": "p_4142", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4143", "content": "cephalothin sodium [SEP] guric renal failure, while they were receiving a combination of cephalothin sodium and gentamicin sulfate therapy. Patients who are given this dru", "tokenized_content": [2, 15221, 17809, 1022, 5227, 3, 3194, 3133, 4604, 4574, 16, 2679, 2611, 1985, 5962, 43, 3921, 1927, 15221, 17809, 1022, 5227, 1930, 17144, 8767, 3181, 18, 2132, 2746, 2032, 3258, 3]}, "items": [{"id": "p_4143", "content": "Cephalothin [SEP] A cephalosporin antibiotic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15221, 17809, 1022, 3, 43, 25091, 1921, 7267, 18, 3]}]}
{"query": {"id": "q_4144", "content": "gentamicin sulfate [SEP] ile they were receiving a combination of cephalothin sodium and gentamicin sulfate therapy. Patients who are given this drug regimen should be obs", "tokenized_content": [2, 17144, 8767, 3, 9940, 2611, 1985, 5962, 43, 3921, 1927, 15221, 17809, 1022, 5227, 1930, 17144, 8767, 3181, 18, 2132, 2746, 2032, 3258, 2052, 2838, 8607, 3066, 1998, 2339, 3]}, "items": [{"id": "p_4144", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_4145", "content": "nephrotoxicity [SEP] ug regimen should be observed very carefully for early signs of nephrotoxicity. High doses of this antibiotic combination should be avoided es", "tokenized_content": [2, 27880, 3, 12522, 8607, 3066, 1998, 2528, 3345, 10801, 1958, 3120, 6879, 1927, 27880, 18, 2149, 5312, 1927, 2052, 7267, 3921, 3066, 1998, 14329, 2376, 3]}, "items": [{"id": "p_4145", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4146", "content": "renal insufficiency [SEP] should be avoided especially in elderly patients. Patients with renal insufficiency should not be given this regimen.", "tokenized_content": [2, 4604, 14566, 3, 3066, 1998, 14329, 4369, 1922, 7354, 2132, 18, 2132, 1956, 4604, 14566, 3066, 2084, 1998, 3258, 2052, 8607, 18, 3]}, "items": [{"id": "p_4146", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4147", "content": "dementia [SEP] Components of lemon essential oil attenuate dementia induced by scopolamine.", "tokenized_content": [2, 7811, 3, 4178, 1927, 15551, 1916, 4415, 6691, 15500, 7811, 2719, 2007, 25392, 10173, 25157, 18, 3]}, "items": [{"id": "p_4147", "content": "Dementia [SEP] An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occup", "score": 1, "type": null, "tokenized_content": [2, 7811, 3, 1925, 5815, 6805, 5018, 4770, 1956, 3257, 1927, 13059, 10957, 1927, 5409, 5155, 1942, 11827, 1956, 3686, 2014, 6027, 3]}]}
{"query": {"id": "q_4148", "content": "scopolamine [SEP] Components of lemon essential oil attenuate dementia induced by scopolamine.", "tokenized_content": [2, 25392, 10173, 25157, 3, 4178, 1927, 15551, 1916, 4415, 6691, 15500, 7811, 2719, 2007, 25392, 10173, 25157, 18, 3]}, "items": [{"id": "p_4148", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_4149", "content": "dementia [SEP] The anti-dementia effects of s-limonene and s-perillyl alcohol were observed usin", "tokenized_content": [2, 7811, 3, 1920, 2246, 17, 7811, 2564, 1927, 61, 17, 2784, 2290, 2912, 1930, 61, 17, 2953, 11560, 2199, 4284, 1985, 2528, 2022, 1921, 3]}, "items": [{"id": "p_4149", "content": "Dementia [SEP] An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occup", "score": 1, "type": null, "tokenized_content": [2, 7811, 3, 1925, 5815, 6805, 5018, 4770, 1956, 3257, 1927, 13059, 10957, 1927, 5409, 5155, 1942, 11827, 1956, 3686, 2014, 6027, 3]}]}
{"query": {"id": "q_4150", "content": "s-limonene [SEP] The anti-dementia effects of s-limonene and s-perillyl alcohol were observed using the passive avoidanc", "tokenized_content": [2, 61, 17, 2784, 2290, 2912, 3, 1920, 2246, 17, 7811, 2564, 1927, 61, 17, 2784, 2290, 2912, 1930, 61, 17, 2953, 11560, 2199, 4284, 1985, 2528, 2193, 1920, 9832, 5161, 3]}, "items": [{"id": "p_4150", "content": "limonene [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2784, 2290, 2912, 3, 3]}]}
{"query": {"id": "q_4151", "content": "s-perillyl alcohol [SEP] The anti-dementia effects of s-limonene and s-perillyl alcohol were observed using the passive avoidance test (PA) and the ope", "tokenized_content": [2, 61, 17, 2953, 11560, 2199, 4284, 3, 1920, 2246, 17, 7811, 2564, 1927, 61, 17, 2784, 2290, 2912, 1930, 61, 17, 2953, 11560, 2199, 4284, 1985, 2528, 2193, 1920, 9832, 3]}, "items": [{"id": "p_4151", "content": "perilla alcohol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2953, 11560, 1019, 4284, 3, 3]}]}
{"query": {"id": "q_4152", "content": "memory impaired [SEP] H). These lemon essential oils showed strong ability to improve memory impaired by scopolamine; however, s-perillyl alcohol relieved the defici", "tokenized_content": [2, 4525, 5761, 3, 50, 13, 18, 2144, 15551, 1916, 4415, 16984, 2594, 3206, 3682, 1942, 3326, 4525, 5761, 2007, 25392, 10173, 25157, 31, 2406, 16, 61, 17, 2953, 11560, 2199, 3]}, "items": [{"id": "p_4152", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_4153", "content": "scopolamine [SEP] ential oils showed strong ability to improve memory impaired by scopolamine; however, s-perillyl alcohol relieved the deficit of associativ", "tokenized_content": [2, 25392, 10173, 25157, 3, 5080, 1923, 16984, 2594, 3206, 3682, 1942, 3326, 4525, 5761, 2007, 25392, 10173, 25157, 31, 2406, 16, 61, 17, 2953, 11560, 2199, 4284, 27919, 1920, 10506, 3]}, "items": [{"id": "p_4153", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_4154", "content": "deficit of associative memory [SEP] paired by scopolamine; however, s-perillyl alcohol relieved the deficit of associative memory in PA only, and did not improve non-associative memory signific", "tokenized_content": [2, 10506, 1927, 20216, 4525, 3, 7304, 2007, 25392, 10173, 25157, 31, 2406, 16, 61, 17, 2953, 11560, 2199, 4284, 27919, 1920, 10506, 1927, 20216, 4525, 1922, 3838, 2444, 16, 1930, 3]}, "items": [{"id": "p_4154", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_4155", "content": "dopamine [SEP] concentration in some brain regions on the test day showed that dopamine concentration of the vehicle/scopolamine group was significantl", "tokenized_content": [2, 7964, 3, 3110, 1922, 2673, 3068, 3451, 1990, 1920, 2648, 3007, 2594, 1988, 7964, 3110, 1927, 1920, 6463, 19, 25392, 10173, 25157, 2210, 1982, 2228, 1024, 3]}, "items": [{"id": "p_4155", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4156", "content": "Ro4368554 [SEP] The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic mod", "tokenized_content": [2, 3039, 7514, 6735, 7054, 1006, 3, 1920, 5328, 25, 17, 5334, 1016, 3148, 8151, 3039, 7514, 6735, 7054, 1006, 24423, 4525, 3604, 1922, 13908, 1930, 21292, 2157, 3]}, "items": [{"id": "p_4156", "content": "Ro4368554 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3039, 7514, 6735, 7054, 1006, 3, 3]}]}
{"query": {"id": "q_4157", "content": "memory deficiency [SEP] es memory performance in cholinergic and serotonergic models of memory deficiency in the rat.", "tokenized_content": [2, 4525, 6179, 3, 2376, 4525, 3604, 1922, 13908, 1930, 21292, 3130, 1927, 4525, 6179, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4157", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_4158", "content": "serotonin [SEP] Antagonists at serotonin type 6 (5-HT(6)) receptors show activity in models of learning ", "tokenized_content": [2, 11153, 3, 10515, 2019, 11153, 2601, 26, 12, 25, 17, 5334, 12, 26, 13, 13, 4086, 2146, 2455, 1922, 3130, 1927, 4809, 3]}, "items": [{"id": "p_4158", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4159", "content": "5-HT [SEP] Antagonists at serotonin type 6 (5-HT(6)) receptors show activity in models of learning and memory. A", "tokenized_content": [2, 25, 17, 5334, 3, 10515, 2019, 11153, 2601, 26, 12, 25, 17, 5334, 12, 26, 13, 13, 4086, 2146, 2455, 1922, 3130, 1927, 4809, 1930, 4525, 18, 43, 3]}, "items": [{"id": "p_4159", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4160", "content": "acetylcholine [SEP] e not well understood, these effects may involve an increase in acetylcholine (ACh) levels. The present study sought to characterize the cogn", "tokenized_content": [2, 14561, 3, 47, 2084, 2486, 7372, 16, 2144, 2564, 2278, 8156, 1925, 2760, 1922, 14561, 12, 3546, 13, 2428, 18, 1920, 2481, 2161, 8758, 1942, 8063, 1920, 3912, 3]}, "items": [{"id": "p_4160", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_4161", "content": "ACh [SEP] rstood, these effects may involve an increase in acetylcholine (ACh) levels. The present study sought to characterize the cognitive", "tokenized_content": [2, 3546, 3, 4366, 4575, 1986, 16, 2144, 2564, 2278, 8156, 1925, 2760, 1922, 14561, 12, 3546, 13, 2428, 18, 1920, 2481, 2161, 8758, 1942, 8063, 1920, 4328, 3]}, "items": [{"id": "p_4161", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_4162", "content": "Ro4368554 [SEP] erize the cognitive-enhancing effects of the 5-HT(6) antagonist Ro4368554 (3-benzenesulfonyl-7-(4-methyl-piperazin-1-yl)1H-indole) in a r", "tokenized_content": [2, 3039, 7514, 6735, 7054, 1006, 3, 2668, 2606, 1920, 4328, 17, 9221, 2564, 1927, 1920, 25, 17, 5334, 12, 26, 13, 8151, 3039, 7514, 6735, 7054, 1006, 12, 23, 17, 3]}, "items": [{"id": "p_4162", "content": "Ro4368554 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3039, 7514, 6735, 7054, 1006, 3, 3]}]}
{"query": {"id": "q_4163", "content": "3-benzenesulfonyl-7-(4-methyl-piperazin-1-yl)1H-indole [SEP] ognitive-enhancing effects of the 5-HT(6) antagonist Ro4368554 (3-benzenesulfonyl-7-(4-methyl-piperazin-1-yl)1H-indole) in a rat object recognition task employing a cholinergic (scop", "tokenized_content": [2, 23, 17, 18536, 27745, 17, 27, 17, 12, 24, 17, 4963, 17, 16057, 25823, 17, 21, 17, 12111, 13, 5189, 17, 18050, 3, 17395, 8635, 2185, 17, 9221, 2564, 1927, 3]}, "items": [{"id": "p_4163", "content": "Ro4368554 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3039, 7514, 6735, 7054, 1006, 3, 3]}]}
{"query": {"id": "q_4164", "content": "scopolamine [SEP] dole) in a rat object recognition task employing a cholinergic (scopolamine pretreatment) and a serotonergic- (tryptophan (TRP) depletion) ", "tokenized_content": [2, 25392, 10173, 25157, 3, 17837, 1021, 13, 1922, 43, 3067, 8032, 5708, 3909, 12003, 43, 13908, 12, 25392, 10173, 25157, 9111, 13, 1930, 43, 21292, 17, 12, 13489, 12, 7259, 3]}, "items": [{"id": "p_4164", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_4165", "content": "tryptophan [SEP] g a cholinergic (scopolamine pretreatment) and a serotonergic- (tryptophan (TRP) depletion) deficient model, and compared its pattern of a", "tokenized_content": [2, 13489, 3, 49, 43, 13908, 12, 25392, 10173, 25157, 9111, 13, 1930, 43, 21292, 17, 12, 13489, 12, 7259, 13, 6882, 13, 5778, 2322, 16, 1930, 2452, 2496, 3114, 1927, 3]}, "items": [{"id": "p_4165", "content": "Tryptophan [SEP] An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of ", "score": 1, "type": null, "tokenized_content": [2, 13489, 3, 1925, 4415, 3835, 2687, 1988, 1977, 4680, 1958, 2791, 2905, 1922, 5969, 1930, 1958, 6634, 6766, 1922, 4440, 18, 2176, 1977, 43, 7897, 1927, 3]}]}
{"query": {"id": "q_4166", "content": "TRP [SEP] gic (scopolamine pretreatment) and a serotonergic- (tryptophan (TRP) depletion) deficient model, and compared its pattern of action", "tokenized_content": [2, 7259, 3, 7217, 1030, 12, 25392, 10173, 25157, 9111, 13, 1930, 43, 21292, 17, 12, 13489, 12, 7259, 13, 6882, 13, 5778, 2322, 16, 1930, 2452, 2496, 3114, 1927, 4615, 3]}, "items": [{"id": "p_4166", "content": "Tryptophan [SEP] An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of ", "score": 1, "type": null, "tokenized_content": [2, 13489, 3, 1925, 4415, 3835, 2687, 1988, 1977, 4680, 1958, 2791, 2905, 1922, 5969, 1930, 1958, 6634, 6766, 1922, 4440, 18, 2176, 1977, 43, 7897, 1927, 3]}]}
{"query": {"id": "q_4167", "content": "metrifonate [SEP] ttern of action with that of the acetylcholinesterase inhibitor metrifonate. Initial testing in a time-dependent forgetting task employing ", "tokenized_content": [2, 2130, 3027, 15282, 5791, 1021, 3, 7382, 1915, 1022, 1927, 4615, 1956, 1988, 1927, 1920, 30003, 4106, 2130, 3027, 15282, 5791, 1021, 18, 3754, 4213, 1922, 43, 2367, 17, 3100, 3]}, "items": [{"id": "p_4167", "content": "Trichlorfon [SEP] An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is als", "score": 1, "type": null, "tokenized_content": [2, 24065, 15282, 1022, 3, 1925, 3090, 20845, 15707, 15440, 2156, 7124, 4127, 4106, 1988, 1977, 2251, 1966, 1925, 21578, 1958, 1920, 2285, 1927, 10130, 1930, 3039, 16565, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_4168", "content": "memory deficits [SEP] (i.p.)) and metrifonate (10 mg/kg, p.o., respectively) reversed memory deficits induced by scopolamine and TRP depletion (10 mg/kg, i.p., and 3", "tokenized_content": [2, 4525, 7961, 3, 12, 51, 18, 58, 18, 13, 13, 1930, 2130, 3027, 15282, 5791, 1021, 12, 2119, 2786, 19, 3621, 16, 58, 18, 57, 18, 16, 2763, 13, 9432, 3]}, "items": [{"id": "p_4168", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_4169", "content": "memory deficit [SEP] (i.p.)) and metrifonate (10 mg/kg, p.o., respectively) reversed memory deficits induced by scopolamine and TRP depletion (10 mg/kg, i.p., and ", "tokenized_content": [2, 4525, 10506, 3, 12, 51, 18, 58, 18, 13, 13, 1930, 2130, 3027, 15282, 5791, 1021, 12, 2119, 2786, 19, 3621, 16, 58, 18, 57, 18, 16, 2763, 13, 9432, 3]}, "items": [{"id": "p_4169", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_4170", "content": "atrial fibrillation [SEP] Lone atrial fibrillation associated with creatine monohydrate supplementation.", "tokenized_content": [2, 9224, 13671, 3, 10969, 1021, 9224, 13671, 2458, 1956, 17784, 8914, 10806, 2010, 8746, 18, 3]}, "items": [{"id": "p_4170", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_4171", "content": "creatine [SEP] Lone atrial fibrillation associated with creatine monohydrate supplementation.", "tokenized_content": [2, 17784, 3, 10969, 1021, 9224, 13671, 2458, 1956, 17784, 8914, 10806, 2010, 8746, 18, 3]}, "items": [{"id": "p_4171", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_4172", "content": "Atrial fibrillation [SEP] Atrial fibrillation in young patients without structural heart disease is rare. The", "tokenized_content": [2, 9224, 13671, 3, 9224, 13671, 1922, 4201, 2132, 2979, 4346, 4003, 2573, 1977, 5844, 18, 1920, 3]}, "items": [{"id": "p_4172", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_4173", "content": "heart disease [SEP] Atrial fibrillation in young patients without structural heart disease is rare. Therefore, when the arrhythmia is present in this popu", "tokenized_content": [2, 4003, 2573, 3, 9224, 13671, 1922, 4201, 2132, 2979, 4346, 4003, 2573, 1977, 5844, 18, 2955, 16, 2469, 1920, 18346, 1977, 2481, 1922, 2052, 2640, 1032, 3]}, "items": [{"id": "p_4173", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_4174", "content": "arrhythmia [SEP] s without structural heart disease is rare. Therefore, when the arrhythmia is present in this population, reversible causes must be identi", "tokenized_content": [2, 18346, 3, 61, 2979, 4346, 4003, 2573, 1977, 5844, 18, 2955, 16, 2469, 1920, 18346, 1977, 2481, 1922, 2052, 2973, 16, 10743, 5092, 4902, 1998, 6424, 3]}, "items": [{"id": "p_4174", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_4175", "content": "Thyroid disorders [SEP]  population, reversible causes must be identified and resolved. Thyroid disorders, illicit drug or stimulant use, and acute alcohol intoxication ", "tokenized_content": [2, 6918, 4414, 3, 2973, 16, 10743, 5092, 4902, 1998, 2899, 1930, 8397, 18, 6918, 4414, 16, 20881, 2838, 2014, 24252, 2485, 16, 1930, 3939, 4284, 20965, 3]}, "items": [{"id": "p_4175", "content": "Thyroid Diseases [SEP] Pathological processes involving the THYROID GLAND.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6918, 3902, 3, 6598, 4028, 5884, 1920, 6918, 8359, 18, 3]}]}
{"query": {"id": "q_4176", "content": "acute alcohol intoxication [SEP] resolved. Thyroid disorders, illicit drug or stimulant use, and acute alcohol intoxication are among these causes. We report the case of a 30-year-old Cau", "tokenized_content": [2, 3939, 4284, 20965, 3, 8397, 18, 6918, 4414, 16, 20881, 2838, 2014, 24252, 2485, 16, 1930, 3939, 4284, 20965, 2032, 2706, 2144, 5092, 18, 2038, 3809, 1920, 3087, 1927, 43, 3]}, "items": [{"id": "p_4176", "content": "Alcoholic Intoxication [SEP] An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15521, 20965, 3, 1925, 3939, 3068, 4741, 2154, 2274, 2037, 1920, 9122, 14195, 1927, 5757, 2014, 15521, 19860, 18, 3]}]}
{"query": {"id": "q_4177", "content": "atrial fibrillation [SEP] -year-old Caucasian man who came to the emergency department in atrial fibrillation with rapid ventricular response. His medical history was unrema", "tokenized_content": [2, 9224, 13671, 3, 17, 2476, 17, 4156, 13472, 2323, 2746, 12411, 1942, 1920, 7877, 6143, 1922, 9224, 13671, 1956, 4052, 6493, 2644, 18, 4167, 3423, 4403, 1982, 13497, 3368, 3]}, "items": [{"id": "p_4177", "content": "Atrial Fibrillation [SEP] Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the", "score": 1, "type": null, "tokenized_content": [2, 9224, 13671, 3, 4552, 4435, 11529, 1988, 1977, 4378, 2007, 4052, 16, 20732, 2538, 4597, 9700, 1927, 8287, 21896, 1036, 1922, 1920, 5199, 13765, 1927, 1920, 3]}]}
{"query": {"id": "q_4178", "content": "fractures [SEP] esponse. His medical history was unremarkable, except for minor fractures of the fingers and foot. Thyroid-stimulating hormone, magnesium", "tokenized_content": [2, 9018, 3, 21929, 2101, 1021, 18, 4167, 3423, 4403, 1982, 28456, 16, 5574, 1958, 5857, 9018, 1927, 1920, 18233, 1930, 8135, 18, 6918, 17, 9868, 6365, 16, 13148, 3]}, "items": [{"id": "p_4178", "content": "Fractures, Bone [SEP] Breaks in bones.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9018, 16, 3622, 3, 13065, 1922, 14153, 18, 3]}]}
{"query": {"id": "q_4179", "content": "magnesium [SEP] fractures of the fingers and foot. Thyroid-stimulating hormone, magnesium, and potassium levels were within normal limits, urine drug scr", "tokenized_content": [2, 13148, 3, 9018, 1927, 1920, 18233, 1930, 8135, 18, 6918, 17, 9868, 6365, 16, 13148, 16, 1930, 9057, 2428, 1985, 2651, 2791, 8183, 16, 6960, 2838, 7572, 3]}, "items": [{"id": "p_4179", "content": "Magnesium [SEP] A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of", "score": 1, "type": null, "tokenized_content": [2, 13148, 3, 43, 16790, 6149, 1988, 2258, 1920, 11241, 17530, 2786, 16, 11241, 2529, 2369, 16, 1930, 11241, 3388, 2686, 18, 3470, 18, 2176, 1977, 2715, 1958, 1920, 2455, 1927, 3]}]}
{"query": {"id": "q_4180", "content": "potassium [SEP] e fingers and foot. Thyroid-stimulating hormone, magnesium, and potassium levels were within normal limits, urine drug screen was negativ", "tokenized_content": [2, 9057, 3, 47, 18233, 1930, 8135, 18, 6918, 17, 9868, 6365, 16, 13148, 16, 1930, 9057, 2428, 1985, 2651, 2791, 8183, 16, 6960, 2838, 7053, 1982, 2922, 1968, 1020, 3]}, "items": [{"id": "p_4180", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_4181", "content": "alcohol [SEP] ed. Thyroid disorders, illicit drug or stimulant use, and acute alcohol intoxication are among these causes. We report the case of a 30", "tokenized_content": [2, 4284, 3, 3347, 18, 6918, 4414, 16, 20881, 2838, 2014, 24252, 2485, 16, 1930, 3939, 4284, 20965, 2032, 2706, 2144, 5092, 18, 2038, 3809, 1920, 3087, 1927, 43, 2627, 3]}, "items": [{"id": "p_4181", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_4182", "content": "creatine [SEP] tioned about use of herbal products and supplements, the use of creatine monohydrate was revealed. The patient was admitted to the hospi", "tokenized_content": [2, 17784, 3, 8685, 14747, 3001, 2485, 1927, 15953, 4461, 1930, 13856, 16, 1920, 2485, 1927, 17784, 8914, 10806, 2010, 1982, 3404, 18, 1920, 2774, 1982, 9723, 1942, 1920, 3219, 1033, 3]}, "items": [{"id": "p_4182", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_4183", "content": "heparin [SEP] as admitted to the hospital, anticoagulated with unfractionated heparin, and given intravenous diltiazem for rate control and intraveno", "tokenized_content": [2, 9962, 3, 1966, 9723, 1942, 1920, 3461, 16, 15496, 1981, 1956, 6281, 27320, 1981, 9962, 16, 1930, 3258, 7307, 4333, 11574, 6931, 1035, 1958, 2769, 2285, 1930, 6306, 19824, 3]}, "items": [{"id": "p_4183", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_4184", "content": "diltiazem [SEP] ticoagulated with unfractionated heparin, and given intravenous diltiazem for rate control and intravenous amiodarone for rate and rhythm", "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 18298, 6952, 11056, 15793, 1956, 6281, 27320, 1981, 9962, 16, 1930, 3258, 7307, 4333, 11574, 6931, 1035, 1958, 2769, 2285, 1930, 7307, 15665, 25033, 2830, 3]}, "items": [{"id": "p_4184", "content": "Diltiazem [SEP] A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.", "score": 1, "type": null, "tokenized_content": [2, 4333, 11574, 6931, 1035, 3, 43, 19225, 22523, 25360, 10533, 1956, 13662, 2287, 4615, 2810, 1942, 2496, 18394, 1927, 1920, 7728, 1927, 5016, 4755, 1990, 3260, 4088, 18, 3]}]}
{"query": {"id": "q_4185", "content": "amiodarone [SEP] nd given intravenous diltiazem for rate control and intravenous amiodarone for rate and rhythm control. When discharged less than 24 hours", "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 8026, 3258, 7307, 4333, 11574, 6931, 1035, 1958, 2769, 2285, 1930, 7307, 15665, 25033, 2830, 1021, 1958, 2769, 1930, 11529, 2285, 18, 2469, 14062, 2941, 3]}, "items": [{"id": "p_4185", "content": "Amiodarone [SEP] An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibitin", "score": 1, "type": null, "tokenized_content": [2, 15665, 25033, 2830, 1021, 3, 1925, 2246, 9506, 3163, 1930, 2921, 4337, 2246, 23246, 4913, 2838, 18, 2176, 4041, 1920, 4392, 1927, 6493, 1930, 9224, 3760, 4615, 2007, 2875, 1921, 3]}]}
{"query": {"id": "q_4186", "content": "metoprolol [SEP] rol. When discharged less than 24 hours later, he was receiving metoprolol and aspirin, with follow-up plans for echocardiography and nucl", "tokenized_content": [2, 2130, 17712, 1945, 3, 29144, 18, 2469, 14062, 2941, 2254, 2686, 3967, 3690, 16, 2234, 1982, 5962, 2130, 17712, 1945, 1930, 12396, 16, 1956, 2396, 17, 2353, 11876, 1958, 12814, 3]}, "items": [{"id": "p_4186", "content": "Metoprolol [SEP] A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMI", "score": 1, "type": null, "tokenized_content": [2, 2130, 17712, 1945, 3, 43, 5328, 13672, 4666, 17, 21, 7472, 5899, 1988, 1977, 5384, 2251, 1942, 2297, 16961, 23540, 1937, 31, 5579, 31, 1930, 4435, 11335, 7395, 3]}]}
{"query": {"id": "q_4187", "content": "aspirin [SEP] arged less than 24 hours later, he was receiving metoprolol and aspirin, with follow-up plans for echocardiography and nuclear imaging ", "tokenized_content": [2, 12396, 3, 4582, 1919, 2941, 2254, 2686, 3967, 3690, 16, 2234, 1982, 5962, 2130, 17712, 1945, 1930, 12396, 16, 1956, 2396, 17, 2353, 11876, 1958, 12814, 1930, 4254, 3755, 3]}, "items": [{"id": "p_4187", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_4188", "content": "toxicity [SEP] Comparison of developmental toxicity of selective and non-selective cyclooxygenase-2 inhibitors in C", "tokenized_content": [2, 5532, 3, 3723, 1927, 5878, 5532, 1927, 5328, 1930, 2447, 17, 5328, 21271, 17, 22, 4472, 1922, 45, 3]}, "items": [{"id": "p_4188", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4189", "content": "DFU [SEP] ective cyclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats--DFU and piroxicam study.", "tokenized_content": [2, 8122, 1032, 3, 7495, 2320, 21271, 17, 22, 4472, 1922, 21460, 30, 12, 11980, 13, 12702, 2377, 15668, 3615, 17, 17, 8122, 1032, 1930, 13774, 10605, 1976, 2161, 18, 3]}, "items": [{"id": "p_4189", "content": "5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25, 16, 25, 17, 9780, 17, 23, 17, 12, 23, 17, 16191, 17616, 2199, 13, 17, 24, 17, 12, 24, 17, 4963, 27745, 13, 7971, 17, 22, 12, 13437, 13, 17, 28028, 29591, 1021, 3, 3]}]}
{"query": {"id": "q_4190", "content": "piroxicam [SEP] yclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats--DFU and piroxicam study.", "tokenized_content": [2, 13774, 10605, 1976, 3, 22386, 6012, 13966, 17, 22, 4472, 1922, 21460, 30, 12, 11980, 13, 12702, 2377, 15668, 3615, 17, 17, 8122, 1032, 1930, 13774, 10605, 1976, 2161, 18, 3]}, "items": [{"id": "p_4190", "content": "Piroxicam [SEP] A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 13774, 10605, 1976, 3, 43, 21271, 7918, 16, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 1977, 2486, 4379, 1922, 8247, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_4191", "content": "toxicity [SEP]  the most often ingested drugs during pregnancy. Unlike general toxicity data, their prenatal toxic effects were not extensively studied", "tokenized_content": [2, 5532, 3, 1920, 2501, 3868, 20833, 4195, 2409, 5284, 18, 7945, 3335, 5532, 2230, 16, 2310, 10907, 6161, 2564, 1985, 2084, 9172, 3942, 3]}, "items": [{"id": "p_4191", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4192", "content": "piroxicam [SEP] as to evaluate the developmental toxicity of the non-selective (piroxicam) and selective (DFU; 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methy", "tokenized_content": [2, 13774, 10605, 1976, 3, 1966, 1942, 4323, 1920, 5878, 5532, 1927, 1920, 2447, 17, 5328, 12, 13774, 10605, 1976, 13, 1930, 5328, 12, 8122, 1032, 31, 25, 16, 25, 17, 3]}, "items": [{"id": "p_4192", "content": "Piroxicam [SEP] A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthr", "score": 1, "type": null, "tokenized_content": [2, 13774, 10605, 1976, 3, 43, 21271, 7918, 16, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 1977, 2486, 4379, 1922, 8247, 13053, 9273, 1005, 3]}]}
{"query": {"id": "q_4193", "content": "DFU [SEP] mental toxicity of the non-selective (piroxicam) and selective (DFU; 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl) phenyl-2", "tokenized_content": [2, 8122, 1032, 3, 5018, 5532, 1927, 1920, 2447, 17, 5328, 12, 13774, 10605, 1976, 13, 1930, 5328, 12, 8122, 1032, 31, 25, 16, 25, 17, 9780, 17, 23, 17, 12, 3]}, "items": [{"id": "p_4193", "content": "5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25, 16, 25, 17, 9780, 17, 23, 17, 12, 23, 17, 16191, 17616, 2199, 13, 17, 24, 17, 12, 24, 17, 4963, 27745, 13, 7971, 17, 22, 12, 13437, 13, 17, 28028, 29591, 1021, 3, 3]}]}
{"query": {"id": "q_4194", "content": "5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl) phenyl-2(5H)-furanon [SEP] l toxicity of the non-selective (piroxicam) and selective (DFU; 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl) phenyl-2(5H)-furanon) COX-2 inhibitors. METHODS: Drugs were separately, orally once ", "tokenized_content": [2, 25, 16, 25, 17, 9780, 17, 23, 17, 12, 23, 17, 16191, 17616, 2199, 13, 17, 24, 17, 12, 24, 17, 4963, 20490, 13857, 10647, 16323, 1024, 13, 7971, 17, 3]}, "items": [{"id": "p_4194", "content": "5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 25, 16, 25, 17, 9780, 17, 23, 17, 12, 23, 17, 16191, 17616, 2199, 13, 17, 24, 17, 12, 24, 17, 4963, 27745, 13, 7971, 17, 22, 12, 13437, 13, 17, 28028, 29591, 1021, 3, 3]}]}
{"query": {"id": "q_4195", "content": "midline (MD) defects [SEP] he pooled statistical analysis for ventricular septal (VSD) and midline (MD) defects was performed for rat fetuses exposed to piroxicam, selective a", "tokenized_content": [2, 14210, 12, 4445, 13, 6007, 3, 2234, 7803, 3850, 2333, 1958, 6493, 16458, 12, 29075, 13, 1930, 14210, 12, 4445, 13, 6007, 1982, 2593, 1958, 3067, 16110, 4616, 1942, 13774, 3]}, "items": [{"id": "p_4195", "content": "Neural Tube Defects [SEP] Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during t", "score": 1, "type": null, "tokenized_content": [2, 5181, 6723, 6007, 3, 9901, 17360, 1927, 1920, 4101, 7580, 2433, 1930, 6811, 4061, 2712, 1942, 9785, 5181, 6723, 10408, 2409, 62, 3]}]}
{"query": {"id": "q_4196", "content": "intrauterine growth retardation [SEP] based on present and historic data. RESULTS: Maternal toxicity, intrauterine growth retardation, and increase of external and skeletal variations were found in", "tokenized_content": [2, 19497, 2905, 16342, 3, 2454, 1990, 2481, 1930, 9925, 1935, 2230, 18, 2274, 30, 5509, 5532, 16, 19497, 2905, 16342, 16, 1930, 2760, 1927, 5771, 1930, 7345, 6740, 1985, 2435, 3]}, "items": [{"id": "p_4196", "content": "Fetal Growth Retardation [SEP] The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5944, 2905, 16342, 3, 1920, 4574, 1927, 43, 15722, 1942, 13444, 2496, 4100, 5944, 2905, 2019, 2967, 10000, 2632, 18, 3]}]}
{"query": {"id": "q_4197", "content": "increase of external and skeletal variations [SEP] ESULTS: Maternal toxicity, intrauterine growth retardation, and increase of external and skeletal variations were found in rats treated with the highest dose of piroxicam. ", "tokenized_content": [2, 2760, 1927, 5771, 1930, 7345, 6740, 3, 2376, 17620, 30, 5509, 5532, 16, 19497, 2905, 16342, 16, 1930, 2760, 1927, 5771, 1930, 7345, 6740, 1985, 2435, 1922, 3615, 2868, 1956, 3]}, "items": [{"id": "p_4197", "content": "Musculoskeletal Abnormalities [SEP] Congenital structural abnormalities and deformities of the musculoskeletal system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15322, 6754, 3, 9901, 4346, 6754, 1930, 26224, 1927, 1920, 15322, 2433, 18, 3]}]}
{"query": {"id": "q_4198", "content": "midline defects [SEP] inhibitors does not increase the risk of ventricular septal and midline defects in rat when compared to non-selective drugs and historic contro", "tokenized_content": [2, 14210, 6007, 3, 4472, 3731, 2084, 2760, 1920, 2565, 1927, 6493, 16458, 1930, 14210, 6007, 1922, 3067, 2469, 2452, 1942, 2447, 17, 5328, 4195, 1930, 9925, 1935, 9738, 3]}, "items": [{"id": "p_4198", "content": "Neural Tube Defects [SEP] Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during t", "score": 1, "type": null, "tokenized_content": [2, 5181, 6723, 6007, 3, 9901, 17360, 1927, 1920, 4101, 7580, 2433, 1930, 6811, 4061, 2712, 1942, 9785, 5181, 6723, 10408, 2409, 62, 3]}]}
{"query": {"id": "q_4199", "content": "steroids [SEP] Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice.", "tokenized_content": [2, 13039, 3, 6337, 4348, 1927, 3366, 3849, 13039, 3316, 9045, 6925, 2824, 17, 10060, 1922, 2518, 18, 3]}, "items": [{"id": "p_4199", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4200", "content": "cocaine [SEP] Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice.", "tokenized_content": [2, 9045, 3, 6337, 4348, 1927, 3366, 3849, 13039, 3316, 9045, 6925, 2824, 17, 10060, 1922, 2518, 18, 3]}, "items": [{"id": "p_4200", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4201", "content": "seizures [SEP] ective efficacy of neuroactive steroids against cocaine kindled-seizures in mice.", "tokenized_content": [2, 10060, 3, 7495, 2320, 4348, 1927, 3366, 3849, 13039, 3316, 9045, 6925, 2824, 17, 10060, 1922, 2518, 18, 3]}, "items": [{"id": "p_4201", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4202", "content": "steroids [SEP] Neuroactive steroids demonstrate pharmacological actions that have relevance for a h", "tokenized_content": [2, 13039, 3, 3366, 3849, 13039, 4504, 7683, 7728, 1988, 2162, 8043, 1958, 43, 50, 3]}, "items": [{"id": "p_4202", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4203", "content": "psychiatric disorders [SEP] ical actions that have relevance for a host of neurological and psychiatric disorders. They offer protection against seizures in a range of models an", "tokenized_content": [2, 7652, 4414, 3, 14784, 1024, 7728, 1988, 2162, 8043, 1958, 43, 4423, 1927, 7605, 1930, 7652, 4414, 18, 2611, 6260, 6202, 3316, 10060, 1922, 43, 3109, 1927, 3130, 1925, 3]}, "items": [{"id": "p_4203", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4204", "content": "seizures [SEP] ogical and psychiatric disorders. They offer protection against seizures in a range of models and seem to inhibit certain stages of drug", "tokenized_content": [2, 10060, 3, 17395, 2046, 1930, 7652, 4414, 18, 2611, 6260, 6202, 3316, 10060, 1922, 43, 3109, 1927, 3130, 1930, 6521, 1942, 2875, 4908, 5143, 1927, 2838, 3]}, "items": [{"id": "p_4204", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4205", "content": "drug dependence [SEP] ures in a range of models and seem to inhibit certain stages of drug dependence in preclinical assessments. The present study was designed to e", "tokenized_content": [2, 2838, 6816, 3, 6794, 1036, 1922, 43, 3109, 1927, 3130, 1930, 6521, 1942, 2875, 4908, 5143, 1927, 2838, 6816, 1922, 10311, 8593, 18, 1920, 2481, 2161, 1982, 4609, 1942, 47, 3]}, "items": [{"id": "p_4205", "content": "Substance-Related Disorders [SEP] Disorders related to substance abuse.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7311, 17, 2712, 4414, 3, 4414, 2712, 1942, 7311, 7764, 18, 3]}]}
{"query": {"id": "q_4206", "content": "steroid [SEP] Neuroactive steroids demonstrate pharmacological actions that have relevance for a ", "tokenized_content": [2, 9507, 3, 3366, 3849, 13039, 4504, 7683, 7728, 1988, 2162, 8043, 1958, 43, 3]}, "items": [{"id": "p_4206", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4207", "content": "gamma-aminobutyric acid [SEP]  one synthetic neuroactive steroid that positively modulate the gamma-aminobutyric acid (GABA(A)) receptor against the increase in sensitivity to the c", "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 2340, 6830, 3366, 3849, 9507, 1988, 6629, 8480, 1920, 7034, 17, 29093, 2687, 12, 7992, 12, 43, 13, 13, 3148, 3316, 1920, 2760, 1922, 3802, 3]}, "items": [{"id": "p_4207", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_4208", "content": "GABA [SEP] e steroid that positively modulate the gamma-aminobutyric acid (GABA(A)) receptor against the increase in sensitivity to the convuls", "tokenized_content": [2, 7992, 3, 47, 9507, 1988, 6629, 8480, 1920, 7034, 17, 29093, 2687, 12, 7992, 12, 43, 13, 13, 3148, 3316, 1920, 2760, 1922, 3802, 1942, 1920, 4772, 6325, 3]}, "items": [{"id": "p_4208", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_4209", "content": "cocaine [SEP] gainst the increase in sensitivity to the convulsant effects of cocaine engendered by repeated cocaine administration (seizure kindling", "tokenized_content": [2, 9045, 3, 13241, 1031, 1920, 2760, 1922, 3802, 1942, 1920, 4772, 6325, 2031, 2564, 1927, 9045, 3814, 18168, 1919, 2007, 5116, 9045, 4183, 12, 11015, 6925, 3961, 3]}, "items": [{"id": "p_4209", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4210", "content": "seizure [SEP] ogical and psychiatric disorders. They offer protection against seizures in a range of models and seem to inhibit certain stages of dru", "tokenized_content": [2, 11015, 3, 17395, 2046, 1930, 7652, 4414, 18, 2611, 6260, 6202, 3316, 10060, 1922, 43, 3109, 1927, 3130, 1930, 6521, 1942, 2875, 4908, 5143, 1927, 2324, 1032, 3]}, "items": [{"id": "p_4210", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4211", "content": "Allopregnanolone [SEP] gendered by repeated cocaine administration (seizure kindling). Allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), pregnanolone (3alpha-hy", "tokenized_content": [2, 24551, 17473, 4296, 2290, 3, 5125, 1919, 2007, 5116, 9045, 4183, 12, 11015, 6925, 3961, 13, 18, 24551, 17473, 4296, 2290, 12, 5694, 13857, 2722, 17, 8275, 17, 6871, 13857, 3]}, "items": [{"id": "p_4211", "content": "Pregnanolone [SEP] A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4297, 4296, 2290, 3, 43, 4297, 2516, 2435, 1922, 1920, 6960, 1927, 7808, 3089, 1930, 29989, 18, 2176, 2258, 16111, 16, 25810, 3153, 16, 1930, 28514, 3879, 18, 3]}]}
{"query": {"id": "q_4212", "content": "3alpha-hydroxy-5alpha-pregnan-20-one [SEP] ed cocaine administration (seizure kindling). Allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), pregnanolone (3alpha-hydroxy-5beta-pregnan-20-one) and ganaxo", "tokenized_content": [2, 5694, 13857, 2722, 17, 8275, 17, 6871, 13857, 2722, 17, 4297, 1928, 17, 2036, 17, 2340, 3, 3347, 9045, 4183, 12, 11015, 6925, 3961, 13, 18, 24551, 17473, 4296, 2290, 3]}, "items": [{"id": "p_4212", "content": "Pregnanolone [SEP] A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4297, 4296, 2290, 3, 43, 4297, 2516, 2435, 1922, 1920, 6960, 1927, 7808, 3089, 1930, 29989, 18, 2176, 2258, 16111, 16, 25810, 3153, 16, 1930, 28514, 3879, 18, 3]}]}
{"query": {"id": "q_4213", "content": "pregnanolone [SEP] ered by repeated cocaine administration (seizure kindling). Allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), pregnanolone (3alpha-hy", "tokenized_content": [2, 4297, 4296, 2290, 3, 22561, 1007, 2007, 5116, 9045, 4183, 12, 11015, 6925, 3961, 13, 18, 24551, 17473, 4296, 2290, 12, 5694, 13857, 2722, 17, 8275, 17, 6871, 13857, 2722, 3]}, "items": [{"id": "p_4213", "content": "Pregnanolone [SEP] A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4297, 4296, 2290, 3, 43, 4297, 2516, 2435, 1922, 1920, 6960, 1927, 7808, 3089, 1930, 29989, 18, 2176, 2258, 16111, 16, 25810, 3153, 16, 1930, 28514, 3879, 18, 3]}]}
{"query": {"id": "q_4214", "content": "3alpha-hydroxy-5beta-pregnan-20-one [SEP] gnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), pregnanolone (3alpha-hydroxy-5beta-pregnan-20-one) and ganaxolone (a synthetic derivative of allopregnanolone 3al", "tokenized_content": [2, 5694, 13857, 2722, 17, 8275, 17, 7807, 9215, 17, 4297, 1928, 17, 2036, 17, 2340, 3, 9005, 4296, 2290, 12, 5694, 13857, 2722, 17, 8275, 17, 6871, 13857, 2722, 17, 3]}, "items": [{"id": "p_4214", "content": "Pregnanolone [SEP] A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4297, 4296, 2290, 3, 43, 4297, 2516, 2435, 1922, 1920, 6960, 1927, 7808, 3089, 1930, 29989, 18, 2176, 2258, 16111, 16, 25810, 3153, 16, 1930, 28514, 3879, 18, 3]}]}
{"query": {"id": "q_4215", "content": "ganaxolone [SEP] 20-one), pregnanolone (3alpha-hydroxy-5beta-pregnan-20-one) and ganaxolone (a synthetic derivative of allopregnanolone 3alpha-hydroxy-3bet", "tokenized_content": [2, 16249, 3013, 13048, 3, 2036, 17, 2340, 13, 16, 4297, 4296, 2290, 12, 5694, 13857, 2722, 17, 8275, 17, 7807, 9215, 17, 4297, 1928, 17, 2036, 17, 2340, 13, 1930, 3]}, "items": [{"id": "p_4215", "content": "ganaxolone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16249, 3013, 13048, 3, 3]}]}
{"query": {"id": "q_4216", "content": "allopregnanolone [SEP] 5beta-pregnan-20-one) and ganaxolone (a synthetic derivative of allopregnanolone 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one) were tested ", "tokenized_content": [2, 24551, 17473, 4296, 2290, 3, 7807, 9215, 17, 4297, 1928, 17, 2036, 17, 2340, 13, 1930, 16249, 3013, 13048, 12, 43, 6830, 10533, 1927, 24551, 17473, 4296, 2290, 5694, 13857, 3]}, "items": [{"id": "p_4216", "content": "Pregnanolone [SEP] A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4297, 4296, 2290, 3, 43, 4297, 2516, 2435, 1922, 1920, 6960, 1927, 7808, 3089, 1930, 29989, 18, 2176, 2258, 16111, 16, 25810, 3153, 16, 1930, 28514, 3879, 18, 3]}]}
{"query": {"id": "q_4217", "content": "3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one [SEP] one) and ganaxolone (a synthetic derivative of allopregnanolone 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one) were tested for their ability to suppress the expression (anti", "tokenized_content": [2, 5694, 13857, 2722, 17, 8275, 17, 6341, 9215, 17, 4963, 17, 6871, 13857, 2722, 17, 4297, 1928, 17, 2036, 17, 2340, 3, 2340, 13, 1930, 16249, 3013, 13048, 12, 43, 3]}, "items": [{"id": "p_4217", "content": "ganaxolone [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16249, 3013, 13048, 3, 3]}]}
{"query": {"id": "q_4218", "content": "cyclosporine A [SEP] nction and morphology after short-term combination therapy with cyclosporine A, tacrolimus and sirolimus in the rat.", "tokenized_content": [2, 21002, 43, 3, 10409, 2001, 1930, 6076, 2256, 3662, 17, 2576, 3921, 3181, 1956, 21002, 43, 16, 21801, 1930, 4520, 24124, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4218", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4219", "content": "tacrolimus [SEP] ology after short-term combination therapy with cyclosporine A, tacrolimus and sirolimus in the rat.", "tokenized_content": [2, 21801, 3, 2865, 2021, 1012, 2256, 3662, 17, 2576, 3921, 3181, 1956, 21002, 43, 16, 21801, 1930, 4520, 24124, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4219", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4220", "content": "sirolimus [SEP] rt-term combination therapy with cyclosporine A, tacrolimus and sirolimus in the rat.", "tokenized_content": [2, 4520, 24124, 3, 4341, 17, 2576, 3921, 3181, 1956, 21002, 43, 16, 21801, 1930, 4520, 24124, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4220", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4221", "content": "Sirolimus [SEP] BACKGROUND: Sirolimus (SRL) may supplement calcineurin inhibitors in clinical organ t", "tokenized_content": [2, 4520, 24124, 3, 3872, 30, 4520, 24124, 12, 4581, 1024, 13, 2278, 3029, 19555, 4472, 1922, 2535, 3090, 62, 3]}, "items": [{"id": "p_4221", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4222", "content": "SRL [SEP] BACKGROUND: Sirolimus (SRL) may supplement calcineurin inhibitors in clinical organ transp", "tokenized_content": [2, 4581, 1024, 3, 3872, 30, 4520, 24124, 12, 4581, 1024, 13, 2278, 3029, 19555, 4472, 1922, 2535, 3090, 22796, 3]}, "items": [{"id": "p_4222", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4223", "content": "nephrotoxic [SEP] ineurin inhibitors in clinical organ transplantation. These are nephrotoxic, but SRL seems to act differently displaying only minor nephrot", "tokenized_content": [2, 22994, 10605, 3, 11116, 13076, 4472, 1922, 2535, 3090, 6530, 18, 2144, 2032, 22994, 10605, 16, 2308, 4581, 1024, 6123, 1942, 4033, 11874, 13867, 2444, 5857, 22994, 3]}, "items": [{"id": "p_4223", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4224", "content": "cyclosporine A [SEP]  of the kidneys of male Sprague-Dawley rats treated with either cyclosporine A (CsA), tacrolimus (FK506) or SRL as monotherapies or in differe", "tokenized_content": [2, 21002, 43, 3, 1927, 1920, 11770, 1927, 4005, 15684, 17, 15798, 3615, 2868, 1956, 3108, 21002, 43, 12, 12993, 13, 16, 21801, 12, 30269, 13, 2014, 4581, 1024, 1966, 19399, 3]}, "items": [{"id": "p_4224", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4225", "content": "CsA [SEP] of male Sprague-Dawley rats treated with either cyclosporine A (CsA), tacrolimus (FK506) or SRL as monotherapies or in different co", "tokenized_content": [2, 12993, 3, 1927, 4005, 15684, 17, 15798, 3615, 2868, 1956, 3108, 21002, 43, 12, 12993, 13, 16, 21801, 12, 30269, 13, 2014, 4581, 1024, 1966, 19399, 2380, 2026, 2062, 2014, 3]}, "items": [{"id": "p_4225", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4226", "content": "tacrolimus [SEP] e Sprague-Dawley rats treated with either cyclosporine A (CsA), tacrolimus (FK506) or SRL as monotherapies or in different combinations. M", "tokenized_content": [2, 21801, 3, 47, 15684, 17, 15798, 3615, 2868, 1956, 3108, 21002, 43, 12, 12993, 13, 16, 21801, 12, 30269, 13, 2014, 4581, 1024, 1966, 19399, 2380, 2026, 2062, 2014, 1922, 3]}, "items": [{"id": "p_4226", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4227", "content": "FK506 [SEP] wley rats treated with either cyclosporine A (CsA), tacrolimus (FK506) or SRL as monotherapies or in different combinations. METHODS:", "tokenized_content": [2, 30269, 3, 21715, 10676, 3615, 2868, 1956, 3108, 21002, 43, 12, 12993, 13, 16, 21801, 12, 30269, 13, 2014, 4581, 1024, 1966, 19399, 2380, 2026, 2062, 2014, 1922, 2413, 7763, 3]}, "items": [{"id": "p_4227", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4228", "content": "fibrosis [SEP] emi-quantitative scoring system analysing the degree of striped fibrosis, subcapsular fibrosis and the number of basophilic tubules, plu", "tokenized_content": [2, 6769, 3, 2391, 1033, 17, 4794, 9247, 2433, 20930, 1920, 4647, 1927, 29809, 1007, 6769, 16, 5736, 3251, 2168, 6769, 1930, 1920, 2529, 1927, 24701, 1935, 14876, 16, 2123, 1032, 3]}, "items": [{"id": "p_4228", "content": "Fibrosis [SEP] Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other ", "score": 1, "type": null, "tokenized_content": [2, 6769, 3, 2967, 6598, 2625, 2597, 15711, 14948, 2960, 23122, 1036, 2967, 3090, 16, 5394, 1966, 43, 7749, 1927, 4531, 2014, 2303, 3]}]}
{"query": {"id": "q_4229", "content": "fucoidan [SEP] Effect of fucoidan treatment on collagenase-induced intracerebral hemorrhage in ra", "tokenized_content": [2, 15423, 2642, 1928, 3, 2495, 1927, 15423, 2642, 1928, 2311, 1990, 18174, 17, 2719, 24152, 10489, 1922, 4313, 3]}, "items": [{"id": "p_4229", "content": "fucoidan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15423, 2642, 1928, 3, 3]}]}
{"query": {"id": "q_4230", "content": "intracerebral hemorrhage [SEP] Effect of fucoidan treatment on collagenase-induced intracerebral hemorrhage in rats.", "tokenized_content": [2, 24152, 10489, 3, 2495, 1927, 15423, 2642, 1928, 2311, 1990, 18174, 17, 2719, 24152, 10489, 1922, 3615, 18, 3]}, "items": [{"id": "p_4230", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_4231", "content": "brain damage [SEP] Inflammatory cells are postulated to mediate some of the brain damage following ischemic stroke. Intracerebral hemorrhage is associat", "tokenized_content": [2, 3068, 4293, 3, 3769, 2094, 2032, 14024, 1942, 8265, 2673, 1927, 1920, 3068, 4293, 2894, 7427, 5235, 18, 24152, 10489, 1977, 2293, 1926, 3]}, "items": [{"id": "p_4231", "content": "Brain Damage, Chronic [SEP] A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential et", "score": 1, "type": null, "tokenized_content": [2, 3068, 4293, 16, 3724, 3, 43, 2625, 4378, 2007, 2815, 17, 11982, 3068, 5273, 2014, 4293, 16, 5394, 1927, 2559, 3221, 4392, 2014, 4872, 18, 2889, 2140, 3]}]}
{"query": {"id": "q_4232", "content": "ischemic stroke [SEP] ls are postulated to mediate some of the brain damage following ischemic stroke. Intracerebral hemorrhage is associated with more inflammation ", "tokenized_content": [2, 7427, 5235, 3, 6639, 2032, 14024, 1942, 8265, 2673, 1927, 1920, 3068, 4293, 2894, 7427, 5235, 18, 24152, 10489, 1977, 2458, 1956, 2253, 4531, 3]}, "items": [{"id": "p_4232", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_4233", "content": "Intracerebral hemorrhage [SEP]  to mediate some of the brain damage following ischemic stroke. Intracerebral hemorrhage is associated with more inflammation than ischemic stroke. We t", "tokenized_content": [2, 24152, 10489, 3, 1942, 8265, 2673, 1927, 1920, 3068, 4293, 2894, 7427, 5235, 18, 24152, 10489, 1977, 2458, 1956, 2253, 4531, 2254, 7427, 5235, 18, 2038, 62, 3]}, "items": [{"id": "p_4233", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_4234", "content": "inflammation [SEP] chemic stroke. Intracerebral hemorrhage is associated with more inflammation than ischemic stroke. We tested the sulfated polysaccharide fuc", "tokenized_content": [2, 4531, 3, 2975, 1935, 5235, 18, 24152, 10489, 1977, 2458, 1956, 2253, 4531, 2254, 7427, 5235, 18, 2038, 3620, 1920, 26649, 17167, 15423, 3]}, "items": [{"id": "p_4234", "content": "Inflammation [SEP] A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions", "score": 1, "type": null, "tokenized_content": [2, 4531, 3, 43, 6598, 2585, 4378, 2007, 4047, 2014, 12102, 1927, 3878, 4189, 2007, 43, 5386, 1927, 22953, 22284, 1935, 1930, 4399, 5298, 3]}]}
{"query": {"id": "q_4235", "content": "fucoidan [SEP] ion than ischemic stroke. We tested the sulfated polysaccharide fucoidan, which has been reported to reduce inflammatory brain damage, i", "tokenized_content": [2, 15423, 2642, 1928, 3, 4755, 2254, 7427, 5235, 18, 2038, 3620, 1920, 26649, 17167, 15423, 2642, 1928, 16, 2154, 2258, 2252, 2568, 1942, 4412, 3769, 3068, 4293, 16, 51, 3]}, "items": [{"id": "p_4235", "content": "fucoidan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15423, 2642, 1928, 3, 3]}]}
{"query": {"id": "q_4236", "content": "intracerebral hemorrhage [SEP] reported to reduce inflammatory brain damage, in a rat model of intracerebral hemorrhage induced by injection of bacterial collagenase into the caudate ", "tokenized_content": [2, 24152, 10489, 3, 2568, 1942, 4412, 3769, 3068, 4293, 16, 1922, 43, 3067, 2322, 1927, 24152, 10489, 2719, 2007, 4107, 1927, 4543, 18174, 2460, 1920, 18955, 3]}, "items": [{"id": "p_4236", "content": "Cerebral Hemorrhage [SEP] Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with ", "score": 1, "type": null, "tokenized_content": [2, 6329, 10489, 3, 7633, 2460, 2340, 2014, 2321, 6329, 21098, 2710, 1920, 5342, 13086, 1930, 1920, 6329, 4997, 18, 2176, 1977, 3868, 2458, 1956, 3]}]}
{"query": {"id": "q_4237", "content": "hematoma [SEP] venous infusion of fucoidan (30 micrograms h-1) or vehicle. The hematoma was assessed in vivo by magnetic resonance imaging. Motor behav", "tokenized_content": [2, 18984, 3, 8562, 7386, 1927, 15423, 2642, 1928, 12, 2627, 13362, 50, 17, 21, 13, 2014, 6463, 18, 1920, 18984, 1982, 3683, 1922, 3597, 2007, 5691, 6912, 3755, 18, 4842, 3]}, "items": [{"id": "p_4237", "content": "Hematoma [SEP] A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18984, 3, 43, 4957, 1927, 2877, 7008, 1920, 2877, 7208, 18, 18984, 2112, 1998, 6579, 1922, 1925, 3090, 16, 5230, 16, 2014, 2960, 18, 3]}]}
{"query": {"id": "q_4238", "content": "Fucoidan [SEP] skilled forelimb function were tested repeatedly for six weeks. Fucoidan-treated rats exhibited evidence of impaired blood clotting and ", "tokenized_content": [2, 15423, 2642, 1928, 3, 19930, 27582, 2347, 1985, 3620, 14959, 1958, 3798, 3625, 18, 15423, 2642, 1928, 17, 2868, 3615, 5065, 3095, 1927, 5761, 2877, 23625, 1930, 3]}, "items": [{"id": "p_4238", "content": "fucoidan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 15423, 2642, 1928, 3, 3]}]}
{"query": {"id": "q_4239", "content": "impaired blood clotting [SEP] edly for six weeks. Fucoidan-treated rats exhibited evidence of impaired blood clotting and hemodilution, had larger hematomas, and tended to have less", "tokenized_content": [2, 5761, 2877, 23625, 3, 30347, 1012, 1958, 3798, 3625, 18, 15423, 2642, 1928, 17, 2868, 3615, 5065, 3095, 1927, 5761, 2877, 23625, 1930, 3243, 11498, 2306, 16, 2430, 4327, 18984, 3]}, "items": [{"id": "p_4239", "content": "Hemostatic Disorders [SEP] Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood", "score": 1, "type": null, "tokenized_content": [2, 30077, 4414, 3, 6598, 4028, 5884, 1920, 7996, 1927, 2877, 9255, 18, 23963, 7315, 1990, 1920, 7996, 1927, 2877, 7208, 16, 2877, 3]}]}
{"query": {"id": "q_4240", "content": "hemodilution [SEP] -treated rats exhibited evidence of impaired blood clotting and hemodilution, had larger hematomas, and tended to have less inflammation in ", "tokenized_content": [2, 3243, 11498, 2306, 3, 17, 2868, 3615, 5065, 3095, 1927, 5761, 2877, 23625, 1930, 3243, 11498, 2306, 16, 2430, 4327, 18984, 1036, 16, 1930, 10587, 1942, 2162, 2941, 4531, 1922, 3]}, "items": [{"id": "p_4240", "content": "Hemostatic Disorders [SEP] Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood", "score": 1, "type": null, "tokenized_content": [2, 30077, 4414, 3, 6598, 4028, 5884, 1920, 7996, 1927, 2877, 9255, 18, 23963, 7315, 1990, 1920, 7996, 1927, 2877, 7208, 16, 2877, 3]}]}
{"query": {"id": "q_4241", "content": "hematomas [SEP] vidence of impaired blood clotting and hemodilution, had larger hematomas, and tended to have less inflammation in the vicinity of the he", "tokenized_content": [2, 18984, 1036, 3, 7376, 15895, 1021, 1927, 5761, 2877, 23625, 1930, 3243, 11498, 2306, 16, 2430, 4327, 18984, 1036, 16, 1930, 10587, 1942, 2162, 2941, 4531, 1922, 1920, 16741, 1927, 3]}, "items": [{"id": "p_4241", "content": "Hematoma [SEP] A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18984, 3, 43, 4957, 1927, 2877, 7008, 1920, 2877, 7208, 18, 18984, 2112, 1998, 6579, 1922, 1925, 3090, 16, 5230, 16, 2014, 2960, 18, 3]}]}
{"query": {"id": "q_4242", "content": "hemorrhage [SEP] me of the brain damage following ischemic stroke. Intracerebral hemorrhage is associated with more inflammation than ischemic stroke. We t", "tokenized_content": [2, 10489, 3, 2142, 1927, 1920, 3068, 4293, 2894, 7427, 5235, 18, 24152, 10489, 1977, 2458, 1956, 2253, 4531, 2254, 7427, 5235, 18, 2038, 62, 3]}, "items": [{"id": "p_4242", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_4243", "content": "white matter edema [SEP] nd better memory retention in the passive avoidance test. Acute white matter edema and eventual neuronal loss in the striatum adjacent to the hema", "tokenized_content": [2, 4511, 6537, 10144, 3, 8026, 3807, 4525, 7521, 1922, 1920, 9832, 11700, 2648, 18, 3939, 4511, 6537, 10144, 1930, 21199, 5121, 3257, 1922, 1920, 11259, 6811, 1942, 1920, 3243, 1019, 3]}, "items": [{"id": "p_4243", "content": "Brain Edema [SEP] Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular f", "score": 1, "type": null, "tokenized_content": [2, 3068, 10144, 3, 2502, 4776, 2014, 5329, 5466, 1922, 3068, 2960, 18, 8377, 3068, 10144, 12, 11438, 2810, 1942, 2502, 4776, 48, 3]}]}
{"query": {"id": "q_4244", "content": "neuronal loss [SEP] e passive avoidance test. Acute white matter edema and eventual neuronal loss in the striatum adjacent to the hematoma did not differ between", "tokenized_content": [2, 5121, 3257, 3, 47, 9832, 11700, 2648, 18, 3939, 4511, 6537, 10144, 1930, 21199, 5121, 3257, 1922, 1920, 11259, 6811, 1942, 1920, 18984, 2811, 2084, 2129, 2192, 3]}, "items": [{"id": "p_4244", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_4245", "content": "Paracetamol [SEP] Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.", "tokenized_content": [2, 27021, 3, 27021, 17, 2458, 22337, 16, 4487, 19051, 16, 4604, 1930, 6095, 4574, 18, 3]}, "items": [{"id": "p_4245", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_4246", "content": "coma [SEP] Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.", "tokenized_content": [2, 22337, 3, 27021, 17, 2458, 22337, 16, 4487, 19051, 16, 4604, 1930, 6095, 4574, 18, 3]}, "items": [{"id": "p_4246", "content": "Coma [SEP] A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Com", "score": 1, "type": null, "tokenized_content": [2, 22337, 3, 43, 11098, 3360, 1927, 29267, 2971, 2458, 1956, 11365, 6329, 2455, 2037, 2154, 1920, 2725, 5156, 1998, 12529, 6107, 18, 2008, 3]}]}
{"query": {"id": "q_4247", "content": "metabolic acidosis [SEP] Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.", "tokenized_content": [2, 4487, 19051, 3, 27021, 17, 2458, 22337, 16, 4487, 19051, 16, 4604, 1930, 6095, 4574, 18, 3]}, "items": [{"id": "p_4247", "content": "Acidosis [SEP] A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and me", "score": 1, "type": null, "tokenized_content": [2, 19051, 3, 43, 11896, 2625, 1927, 2687, 4858, 2014, 6882, 1927, 5170, 1922, 1920, 3362, 18, 1920, 2288, 2730, 3584, 2032, 5481, 19051, 1930, 2142, 3]}]}
{"query": {"id": "q_4248", "content": "hepatic failure [SEP] Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.", "tokenized_content": [2, 6095, 4574, 3, 27021, 17, 2458, 22337, 16, 4487, 19051, 16, 4604, 1930, 6095, 4574, 18, 3]}, "items": [{"id": "p_4248", "content": "Liver Failure [SEP] Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum leve", "score": 1, "type": null, "tokenized_content": [2, 3568, 4574, 3, 4010, 11752, 1927, 1920, 3568, 1942, 2385, 2496, 2791, 4487, 4088, 16, 1966, 11400, 2007, 4010, 25314, 1930, 4552, 3256, 10157, 1021, 3]}]}
{"query": {"id": "q_4249", "content": "metabolic acidosis [SEP] A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ", "tokenized_content": [2, 4487, 19051, 3, 43, 3087, 1927, 4487, 19051, 16, 3939, 4604, 4574, 1930, 6095, 4574, 2894, 27021, 3]}, "items": [{"id": "p_4249", "content": "Acidosis [SEP] A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and me", "score": 1, "type": null, "tokenized_content": [2, 19051, 3, 43, 11896, 2625, 1927, 2687, 4858, 2014, 6882, 1927, 5170, 1922, 1920, 3362, 18, 1920, 2288, 2730, 3584, 2032, 5481, 19051, 1930, 2142, 3]}]}
{"query": {"id": "q_4250", "content": "acute renal failure [SEP] A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presente", "tokenized_content": [2, 3939, 4604, 4574, 3, 43, 3087, 1927, 4487, 19051, 16, 3939, 4604, 4574, 1930, 6095, 4574, 2894, 27021, 14195, 1977, 2481, 1021, 3]}, "items": [{"id": "p_4250", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_4251", "content": "paracetamol [SEP] lic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented. The diagnostic difficulty at presentati", "tokenized_content": [2, 27021, 3, 10247, 19051, 16, 3939, 4604, 4574, 1930, 6095, 4574, 2894, 27021, 14195, 1977, 3549, 18, 1920, 4785, 8791, 2019, 2481, 1968, 3]}, "items": [{"id": "p_4251", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_4252", "content": "ketoconazole [SEP] Hepatic reactions associated with ketoconazole in the United Kingdom.", "tokenized_content": [2, 21471, 12334, 6984, 3, 6095, 5298, 2458, 1956, 21471, 12334, 6984, 1922, 1920, 6128, 13543, 18, 3]}, "items": [{"id": "p_4252", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_4253", "content": "Ketoconazole [SEP] Ketoconazole was introduced in the United Kingdom in 1981. By November 1984 ", "tokenized_content": [2, 21471, 12334, 6984, 3, 21471, 12334, 6984, 1982, 6373, 1922, 1920, 6128, 13543, 1922, 14661, 18, 2007, 12832, 12812, 3]}, "items": [{"id": "p_4253", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_4254", "content": "hepatotoxicity [SEP] ttee on Safety of Medicines had received 82 reports of possible hepatotoxicity associated with the drug, including five deaths. An analysis of", "tokenized_content": [2, 24126, 3, 7382, 5182, 1990, 5407, 1927, 12864, 2430, 4004, 6175, 4710, 1927, 3216, 24126, 2458, 1956, 1920, 2838, 16, 2710, 3628, 7601, 18, 1925, 2333, 1927, 3]}, "items": [{"id": "p_4254", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4255", "content": "deaths [SEP] ossible hepatotoxicity associated with the drug, including five deaths. An analysis of the 75 cases that had been adequately followed ", "tokenized_content": [2, 7601, 3, 16420, 2563, 24126, 2458, 1956, 1920, 2838, 16, 2710, 3628, 7601, 18, 1925, 2333, 1927, 1920, 4089, 2919, 1988, 2430, 2252, 13498, 3489, 3]}, "items": [{"id": "p_4255", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_4256", "content": "jaundice [SEP] in women. The average duration of treatment before the onset of jaundice was 61 days. None of these well validated cases occurred within", "tokenized_content": [2, 25314, 3, 1922, 3089, 18, 1920, 3361, 4392, 1927, 2311, 3119, 1920, 4727, 1927, 25314, 1982, 5473, 3000, 18, 6046, 1927, 2144, 2486, 6593, 2919, 4807, 2651, 3]}, "items": [{"id": "p_4256", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_4257", "content": "hepatocellular injury [SEP]  treatment. The results of serum liver function tests suggested hepatocellular injury in 10 (63%); the rest showed a mixed pattern. In contrast, the ", "tokenized_content": [2, 12457, 4047, 3, 2311, 18, 1920, 2274, 1927, 3256, 3568, 2347, 4026, 3978, 12457, 4047, 1922, 2119, 12, 4968, 9, 13, 31, 1920, 6172, 2594, 43, 4985, 3114, 18, 1922, 3]}, "items": [{"id": "p_4257", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4258", "content": "cholestasis [SEP]  histological examination of the liver often showed evidence of cholestasis. The characteristics of the 48 patients in the possible cases w", "tokenized_content": [2, 30086, 3, 6791, 4981, 1927, 1920, 3568, 3868, 2594, 3095, 1927, 30086, 18, 1920, 3779, 1927, 1920, 3427, 2132, 1922, 1920, 3216, 2919, 65, 3]}, "items": [{"id": "p_4258", "content": "Cholestasis [SEP] Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EX", "score": 1, "type": null, "tokenized_content": [2, 30086, 3, 6159, 1927, 9619, 3426, 2810, 1942, 10849, 1922, 2858, 9619, 19277, 12, 22323, 30086, 13, 2014, 10849, 1922, 3103, 9619, 19277, 12, 1975, 3]}]}
{"query": {"id": "q_4259", "content": "rash [SEP] he possible cases were similar. Allergic manifestations such as rash and eosinophilia were rare. Hepatitis was usually reversible wh", "tokenized_content": [2, 18469, 3, 2234, 3216, 2919, 1985, 2551, 18, 10519, 10952, 2427, 1966, 18469, 1930, 26887, 1985, 5844, 18, 7977, 1982, 5394, 10743, 2003, 3]}, "items": [{"id": "p_4259", "content": "Exanthema [SEP] Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with sim", "score": 1, "type": null, "tokenized_content": [2, 1975, 7744, 6666, 3, 3902, 1922, 2154, 4407, 25655, 1036, 2014, 18469, 1918, 2032, 43, 8753, 15570, 18, 24466, 16, 3798, 2427, 3902, 1985, 2910, 1956, 2328, 3]}]}
{"query": {"id": "q_4260", "content": "eosinophilia [SEP] le cases were similar. Allergic manifestations such as rash and eosinophilia were rare. Hepatitis was usually reversible when treatment was ", "tokenized_content": [2, 26887, 3, 2071, 2919, 1985, 2551, 18, 10519, 10952, 2427, 1966, 18469, 1930, 26887, 1985, 5844, 18, 7977, 1982, 5394, 10743, 2469, 2311, 1982, 3]}, "items": [{"id": "p_4260", "content": "Eosinophilia [SEP] Abnormal increase of EOSINOPHILS in the blood, tissues or organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26887, 3, 4552, 2760, 1927, 15854, 1922, 1920, 2877, 16, 3878, 2014, 7393, 18, 3]}]}
{"query": {"id": "q_4261", "content": "Hepatitis [SEP] llergic manifestations such as rash and eosinophilia were rare. Hepatitis was usually reversible when treatment was stopped, with the res", "tokenized_content": [2, 7977, 3, 10748, 5237, 10952, 2427, 1966, 18469, 1930, 26887, 1985, 5844, 18, 7977, 1982, 5394, 10743, 2469, 2311, 1982, 12032, 16, 1956, 1920, 1995, 3]}, "items": [{"id": "p_4261", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4262", "content": "ketoconazole [SEP] 3.1 months. In two of the three deaths probably associated with ketoconazole treatment the drug had been continued after the onset of jaundi", "tokenized_content": [2, 21471, 12334, 6984, 3, 23, 18, 21, 3221, 18, 1922, 2288, 1927, 1920, 2559, 7601, 6226, 2458, 1956, 21471, 12334, 6984, 2311, 1920, 2838, 2430, 2252, 7583, 2256, 1920, 4727, 3]}, "items": [{"id": "p_4262", "content": "Ketoconazole [SEP] Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21471, 12334, 6984, 3, 4949, 5648, 15216, 5899, 2251, 1958, 2815, 6696, 2019, 2149, 5312, 16, 4369, 1922, 27996, 1919, 2132, 18, 3]}]}
{"query": {"id": "q_4263", "content": "hepatitis [SEP] een continued after the onset of jaundice and other symptoms of hepatitis. Clinical and biochemical monitoring at regular intervals for e", "tokenized_content": [2, 7977, 3, 11150, 1022, 7583, 2256, 1920, 4727, 1927, 25314, 1930, 2303, 3601, 1927, 7977, 18, 2535, 1930, 6503, 5378, 2019, 6314, 6087, 1958, 47, 3]}, "items": [{"id": "p_4263", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4264", "content": "hepatic injury [SEP] ng term treatment with ketoconazole to prevent possible serious hepatic injury.", "tokenized_content": [2, 6095, 4047, 3, 4375, 2576, 2311, 1956, 21471, 12334, 6984, 1942, 4625, 3216, 7433, 6095, 4047, 18, 3]}, "items": [{"id": "p_4264", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4265", "content": "prostaglandin E1 [SEP] Combined effects of prolonged prostaglandin E1-induced hypotension and haemodilution on human hepatic function", "tokenized_content": [2, 15900, 11123, 3, 4252, 2564, 1927, 7171, 15900, 11123, 17, 2719, 16453, 1930, 7105, 11498, 2306, 1990, 2616, 6095, 2347, 3]}, "items": [{"id": "p_4265", "content": "Alprostadil [SEP] A potent vasodilator agent that increases peripheral blood flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14089, 16289, 2713, 1024, 3, 43, 6828, 28194, 5899, 1988, 4041, 5009, 2877, 3426, 18, 3]}]}
{"query": {"id": "q_4266", "content": "hypotension [SEP] Combined effects of prolonged prostaglandin E1-induced hypotension and haemodilution on human hepatic function.", "tokenized_content": [2, 16453, 3, 4252, 2564, 1927, 7171, 15900, 11123, 17, 2719, 16453, 1930, 7105, 11498, 2306, 1990, 2616, 6095, 2347, 18, 3]}, "items": [{"id": "p_4266", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4267", "content": "haemodilution [SEP] d effects of prolonged prostaglandin E1-induced hypotension and haemodilution on human hepatic function.", "tokenized_content": [2, 7105, 11498, 2306, 3, 46, 2564, 1927, 7171, 15900, 11123, 17, 2719, 16453, 1930, 7105, 11498, 2306, 1990, 2616, 6095, 2347, 18, 3]}, "items": [{"id": "p_4267", "content": "Hemostatic Disorders [SEP] Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood", "score": 1, "type": null, "tokenized_content": [2, 30077, 4414, 3, 6598, 4028, 5884, 1920, 7996, 1927, 2877, 9255, 18, 23963, 7315, 1990, 1920, 7996, 1927, 2877, 7208, 16, 2877, 3]}]}
{"query": {"id": "q_4268", "content": "prostaglandin E1 [SEP] Combined effects of prolonged prostaglandin E1 (PGE1)-induced hypotension and haemodilution on hepatic functio", "tokenized_content": [2, 15900, 11123, 3, 4252, 2564, 1927, 7171, 15900, 11123, 12, 11435, 1009, 13, 17, 2719, 16453, 1930, 7105, 11498, 2306, 1990, 6095, 2277, 2341, 3940, 3]}, "items": [{"id": "p_4268", "content": "Alprostadil [SEP] A potent vasodilator agent that increases peripheral blood flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14089, 16289, 2713, 1024, 3, 43, 6828, 28194, 5899, 1988, 4041, 5009, 2877, 3426, 18, 3]}]}
{"query": {"id": "q_4269", "content": "PGE1 [SEP] Combined effects of prolonged prostaglandin E1 (PGE1)-induced hypotension and haemodilution on hepatic function were", "tokenized_content": [2, 11435, 1009, 3, 4252, 2564, 1927, 7171, 15900, 11123, 12, 11435, 1009, 13, 17, 2719, 16453, 1930, 7105, 11498, 2306, 1990, 6095, 2347, 1985, 3]}, "items": [{"id": "p_4269", "content": "Alprostadil [SEP] A potent vasodilator agent that increases peripheral blood flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14089, 16289, 2713, 1024, 3, 43, 6828, 28194, 5899, 1988, 4041, 5009, 2877, 3426, 18, 3]}]}
{"query": {"id": "q_4270", "content": "hypotension [SEP] Combined effects of prolonged prostaglandin E1 (PGE1)-induced hypotension and haemodilution on hepatic function were studied in 30 patien", "tokenized_content": [2, 16453, 3, 4252, 2564, 1927, 7171, 15900, 11123, 12, 11435, 1009, 13, 17, 2719, 16453, 1930, 7105, 11498, 2306, 1990, 6095, 2347, 1985, 3942, 1922, 2627, 2091, 1917, 3]}, "items": [{"id": "p_4270", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4271", "content": "haemodilution [SEP] ts of prolonged prostaglandin E1 (PGE1)-induced hypotension and haemodilution on hepatic function were studied in 30 patients undergoing hip ", "tokenized_content": [2, 7105, 11498, 2306, 3, 4894, 1927, 7171, 15900, 11123, 12, 11435, 1009, 13, 17, 2719, 16453, 1930, 7105, 11498, 2306, 1990, 6095, 2347, 1985, 3942, 1922, 2627, 2132, 7258, 7679, 3]}, "items": [{"id": "p_4271", "content": "Hemostatic Disorders [SEP] Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood", "score": 1, "type": null, "tokenized_content": [2, 30077, 4414, 3, 6598, 4028, 5884, 1920, 7996, 1927, 2877, 9255, 18, 23963, 7315, 1990, 1920, 7996, 1927, 2877, 7208, 16, 2877, 3]}]}
{"query": {"id": "q_4272", "content": "Haemodilution [SEP] up C (n = 10) to both controlled hypotension and haemodilution. Haemodilution in groups B and C was produced by withdrawing approximately 100", "tokenized_content": [2, 7105, 11498, 2306, 3, 2353, 45, 12, 56, 33, 2119, 13, 1942, 2321, 4642, 16453, 1930, 7105, 11498, 2306, 18, 7105, 11498, 2306, 1922, 2671, 44, 1930, 45, 1982, 4152, 3]}, "items": [{"id": "p_4272", "content": "Hemostatic Disorders [SEP] Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood", "score": 1, "type": null, "tokenized_content": [2, 30077, 4414, 3, 6598, 4028, 5884, 1920, 7996, 1927, 2877, 9255, 18, 23963, 7315, 1990, 1920, 7996, 1927, 2877, 7208, 16, 2877, 3]}]}
{"query": {"id": "q_4273", "content": "dextran [SEP] ately 1000 mL of blood and replacing it with the same amount of dextran solution, and final haematocrit values were 21 or 22%. Controll", "tokenized_content": [2, 15195, 3, 30280, 1954, 5672, 2646, 1927, 2877, 1930, 15325, 2176, 1956, 1920, 2841, 4351, 1927, 15195, 3331, 16, 1930, 3948, 13080, 19170, 2851, 1985, 2900, 2014, 2950, 9, 18, 3]}, "items": [{"id": "p_4273", "content": "Dextrans [SEP] A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagu", "score": 1, "type": null, "tokenized_content": [2, 15195, 1036, 3, 43, 2210, 1927, 3817, 11039, 3915, 2007, 4908, 4802, 18, 15195, 1036, 2032, 2251, 25058, 1966, 3582, 3776, 7305, 2045, 1930, 11693, 2006, 1032, 3]}]}
{"query": {"id": "q_4274", "content": "aceto-acetate [SEP] 80 min. Measurements included arterial ketone body ratio (AKBR, aceto-acetate/3-hydroxybutyrate) and clinical hepatic function parameters. AK", "tokenized_content": [2, 4118, 1037, 17, 7959, 3, 3729, 2360, 18, 4146, 3063, 6624, 21876, 3362, 3400, 12, 4464, 2377, 16, 4118, 1037, 17, 7959, 19, 23, 17, 8275, 16119, 16128, 13, 1930, 3]}, "items": [{"id": "p_4274", "content": "acetoacetic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4118, 21117, 2687, 3, 3]}]}
{"query": {"id": "q_4275", "content": "3-hydroxybutyrate [SEP] ements included arterial ketone body ratio (AKBR, aceto-acetate/3-hydroxybutyrate) and clinical hepatic function parameters. AKBR and biological ", "tokenized_content": [2, 23, 17, 8275, 16119, 16128, 3, 2391, 2039, 3063, 6624, 21876, 3362, 3400, 12, 4464, 2377, 16, 4118, 1037, 17, 7959, 19, 23, 17, 8275, 16119, 16128, 13, 1930, 2535, 3]}, "items": [{"id": "p_4275", "content": "3-Hydroxybutyric Acid [SEP] BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23, 17, 8275, 16119, 19872, 2687, 3, 2308, 19872, 2687, 11798, 1922, 1920, 4666, 2014, 23, 3507, 18, 2176, 1977, 2340, 1927, 1920, 21876, 8322, 4152, 1922, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_4276", "content": "bilirubin [SEP] ) after recovery of normotension, and SGOT, SGPT, LDH and total bilirubin showed significant increases after operation. The results sugge", "tokenized_content": [2, 15702, 3, 13, 2256, 5241, 1927, 21165, 3212, 16, 1930, 10075, 1991, 16, 10075, 2410, 16, 12713, 1930, 2698, 15702, 2594, 2228, 4041, 2256, 7277, 18, 1920, 2274, 2425, 2106, 3]}, "items": [{"id": "p_4276", "content": "Bilirubin [SEP] A bile pigment that is a degradation product of HEME.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15702, 3, 43, 9619, 12905, 1988, 1977, 43, 4877, 4863, 1927, 10954, 18, 3]}]}
{"query": {"id": "q_4277", "content": "impairment of hepatic function [SEP] PGE1-induced hypotension and moderate haemodilution would cause impairment of hepatic function.", "tokenized_content": [2, 6159, 1927, 6095, 2347, 3, 11435, 1009, 17, 2719, 16453, 1930, 5086, 7105, 11498, 2306, 2962, 3936, 6159, 1927, 6095, 2347, 18, 3]}, "items": [{"id": "p_4277", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_4278", "content": "Levodopa [SEP] Levodopa-induced dyskinesias in patients with Parkinson's disease: filli", "tokenized_content": [2, 26723, 3, 26723, 17, 2719, 3890, 26682, 1036, 1922, 2132, 1956, 10124, 11, 61, 2573, 30, 11928, 1033, 3]}, "items": [{"id": "p_4278", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4279", "content": "dyskinesias [SEP] Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-beds", "tokenized_content": [2, 3890, 26682, 1036, 3, 26723, 17, 2719, 3890, 26682, 1036, 1922, 2132, 1956, 10124, 11, 61, 2573, 30, 12919, 1920, 12629, 17, 1942, 17, 19383, 3]}, "items": [{"id": "p_4279", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4280", "content": "Parkinson's disease [SEP] Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap.", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 26723, 17, 2719, 3890, 26682, 1036, 1922, 2132, 1956, 10124, 11, 61, 2573, 30, 12919, 1920, 12629, 17, 1942, 17, 23579, 5750, 18, 3]}, "items": [{"id": "p_4280", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_4281", "content": "Levodopa [SEP] Levodopa is the most effective drug for the treatment of Parkinson's dis", "tokenized_content": [2, 26723, 3, 26723, 1977, 1920, 2501, 3655, 2838, 1958, 1920, 2311, 1927, 10124, 11, 61, 2054, 3]}, "items": [{"id": "p_4281", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4282", "content": "Parkinson's disease [SEP] Levodopa is the most effective drug for the treatment of Parkinson's disease. However, the long-term use of this dopamine precursor is compl", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 26723, 1977, 1920, 2501, 3655, 2838, 1958, 1920, 2311, 1927, 10124, 11, 61, 2573, 18, 2406, 16, 1920, 2815, 17, 2576, 2485, 1927, 2052, 7964, 3]}, "items": [{"id": "p_4282", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_4283", "content": "dopamine [SEP] ment of Parkinson's disease. However, the long-term use of this dopamine precursor is complicated by highly disabling fluctuations and d", "tokenized_content": [2, 7964, 3, 11567, 1927, 10124, 11, 61, 2573, 18, 2406, 16, 1920, 2815, 17, 2576, 2485, 1927, 2052, 7964, 7897, 1977, 9881, 2007, 3626, 27606, 11429, 1930, 46, 3]}, "items": [{"id": "p_4283", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4284", "content": "dyskinesias [SEP] e precursor is complicated by highly disabling fluctuations and dyskinesias. Although preclinical and clinical findings suggest pulsatile s", "tokenized_content": [2, 3890, 26682, 1036, 3, 47, 7897, 1977, 9881, 2007, 3626, 27606, 11429, 1930, 3890, 26682, 1036, 18, 2876, 10311, 1930, 2535, 3056, 3220, 25960, 61, 3]}, "items": [{"id": "p_4284", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4285", "content": "levodopa [SEP] f striatal postsynaptic receptors as a key mechanism underlying levodopa-induced dyskinesias, their pathogenesis is still unclear. In re", "tokenized_content": [2, 26723, 3, 48, 13165, 13090, 4086, 1966, 43, 3834, 2856, 5030, 26723, 17, 2719, 3890, 26682, 1036, 16, 2310, 6559, 1977, 3974, 6390, 18, 1922, 1964, 3]}, "items": [{"id": "p_4285", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_4286", "content": "dyskinetic movements [SEP] ost-receptor molecular mechanisms underlying the development of dyskinetic movements. Recent preclinical and clinical data from promising lines of r", "tokenized_content": [2, 3890, 24590, 2002, 8264, 3, 17677, 17, 3148, 3272, 3531, 5030, 1920, 2740, 1927, 3890, 24590, 2002, 8264, 18, 3505, 10311, 1930, 2535, 2230, 2037, 6842, 3557, 1927, 60, 3]}, "items": [{"id": "p_4286", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_4287", "content": "glutamate [SEP] anisms, dopamine receptor subtypes, ionotropic and metabotropic glutamate receptors, and non-dopaminergic neurotransmitter systems in the", "tokenized_content": [2, 7627, 3, 11453, 2800, 16, 7964, 3148, 8160, 16, 4755, 8405, 1930, 18447, 8405, 7627, 4086, 16, 1930, 2447, 17, 12214, 15223, 3771, 1922, 1920, 3]}, "items": [{"id": "p_4287", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_4288", "content": "seizures [SEP] Prevention of seizures and reorganization of hippocampal functions by transplantation ", "tokenized_content": [2, 10060, 3, 5455, 1927, 10060, 1930, 18062, 1927, 7636, 4088, 2007, 6530, 3]}, "items": [{"id": "p_4288", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4289", "content": "epilepsy [SEP] ntation of bone marrow cells in the acute phase of experimental epilepsy.", "tokenized_content": [2, 9741, 3, 20503, 1929, 1927, 3622, 6599, 2094, 1922, 1920, 3939, 3193, 1927, 3599, 9741, 18, 3]}, "items": [{"id": "p_4289", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_4290", "content": "epilepsy [SEP] potential of bone marrow mononuclear cells (BMCs) in a model of epilepsy induced by pilocarpine in rats. BMCs obtained from green fluore", "tokenized_content": [2, 9741, 3, 2889, 1927, 3622, 6599, 12192, 2094, 12, 20936, 1036, 13, 1922, 43, 2322, 1927, 9741, 2719, 2007, 7547, 7095, 12184, 1922, 3615, 18, 20936, 1036, 2926, 2037, 4524, 3]}, "items": [{"id": "p_4290", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_4291", "content": "pilocarpine [SEP] rrow mononuclear cells (BMCs) in a model of epilepsy induced by pilocarpine in rats. BMCs obtained from green fluorescent protein (GFP) tra", "tokenized_content": [2, 7547, 7095, 12184, 3, 5162, 1971, 12192, 2094, 12, 20936, 1036, 13, 1922, 43, 2322, 1927, 9741, 2719, 2007, 7547, 7095, 12184, 1922, 3615, 18, 20936, 1036, 2926, 2037, 4524, 3]}, "items": [{"id": "p_4291", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_4292", "content": "status epilepticus [SEP] mice or rats were transplanted intravenously after induction of status epilepticus (SE). Spontaneous recurrent seizures (SRS) were monitored using", "tokenized_content": [2, 3642, 16304, 1957, 3, 2518, 2014, 3615, 1985, 11726, 15132, 2256, 4408, 1927, 3642, 16304, 1957, 12, 2058, 13, 18, 6242, 7457, 10060, 12, 16018, 13, 1985, 7027, 2193, 3]}, "items": [{"id": "p_4292", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_4293", "content": "SE [SEP] ansplanted intravenously after induction of status epilepticus (SE). Spontaneous recurrent seizures (SRS) were monitored using Rac", "tokenized_content": [2, 2058, 3, 18229, 4043, 1919, 15132, 2256, 4408, 1927, 3642, 16304, 1957, 12, 2058, 13, 18, 6242, 7457, 10060, 12, 16018, 13, 1985, 7027, 2193, 7195, 3]}, "items": [{"id": "p_4293", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_4294", "content": "seizure [SEP] ter induction of status epilepticus (SE). Spontaneous recurrent seizures (SRS) were monitored using Racine's seizure severity scale. Al", "tokenized_content": [2, 11015, 3, 6005, 4408, 1927, 3642, 16304, 1957, 12, 2058, 13, 18, 6242, 7457, 10060, 12, 16018, 13, 1985, 7027, 2193, 7195, 2053, 11, 61, 11015, 5155, 3536, 18, 1969, 3]}, "items": [{"id": "p_4294", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4295", "content": "epileptic [SEP]  rats were transplanted intravenously after induction of status epilepticus (SE). Spontaneous recurrent seizures (SRS) were monitored usi", "tokenized_content": [2, 16304, 3, 3615, 1985, 11726, 15132, 2256, 4408, 1927, 3642, 16304, 1957, 12, 2058, 13, 18, 6242, 7457, 10060, 12, 16018, 13, 1985, 7027, 2022, 1033, 3]}, "items": [{"id": "p_4295", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_4296", "content": "seizures [SEP] ter induction of status epilepticus (SE). Spontaneous recurrent seizures (SRS) were monitored using Racine's seizure severity scale. All", "tokenized_content": [2, 10060, 3, 6005, 4408, 1927, 3642, 16304, 1957, 12, 2058, 13, 18, 6242, 7457, 10060, 12, 16018, 13, 1985, 7027, 2193, 7195, 2053, 11, 61, 11015, 5155, 3536, 18, 2136, 3]}, "items": [{"id": "p_4296", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4297", "content": "neuronal loss [SEP] th BMCs can prevent the development of chronic seizures, reduce neuronal loss, and influence the reorganization of the hippocampal neuronal n", "tokenized_content": [2, 5121, 3257, 3, 1913, 20936, 1036, 2112, 4625, 1920, 2740, 1927, 3724, 10060, 16, 4412, 5121, 3257, 16, 1930, 4039, 1920, 18062, 1927, 1920, 7636, 5121, 56, 3]}, "items": [{"id": "p_4297", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_4298", "content": "salvianolic acid A [SEP] Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 14623, 25627, 3742, 2687, 43, 3, 28063, 2495, 1927, 14623, 25627, 3742, 2687, 43, 1990, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_4298", "content": "salvianolic acid A [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14623, 25627, 3742, 2687, 43, 3, 3]}]}
{"query": {"id": "q_4299", "content": "isoproterenol [SEP] Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 23743, 3, 28063, 2495, 1927, 14623, 25627, 3742, 2687, 43, 1990, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_4299", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_4300", "content": "myocardial infarction [SEP] rotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats.", "tokenized_content": [2, 6497, 8358, 3, 5337, 2451, 2495, 1927, 14623, 25627, 3742, 2687, 43, 1990, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_4300", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_4301", "content": "salvianolic acid A [SEP] tudy was designed to evaluate the cardioprotective potential of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. Hemodyn", "tokenized_content": [2, 14623, 25627, 3742, 2687, 43, 3, 9037, 14458, 1982, 4609, 1942, 4323, 1920, 28063, 2889, 1927, 14623, 25627, 3742, 2687, 43, 1990, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 3]}, "items": [{"id": "p_4301", "content": "salvianolic acid A [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14623, 25627, 3742, 2687, 43, 3, 3]}]}
{"query": {"id": "q_4302", "content": "isoproterenol [SEP] valuate the cardioprotective potential of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. Hemodynamic parameters a", "tokenized_content": [2, 23743, 3, 8302, 2010, 1920, 28063, 2889, 1927, 14623, 25627, 3742, 2687, 43, 1990, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 12173, 3673, 43, 3]}, "items": [{"id": "p_4302", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_4303", "content": "myocardial infarction [SEP] ective potential of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. Hemodynamic parameters and lead II electrocardiograph ", "tokenized_content": [2, 6497, 8358, 3, 7495, 2320, 2889, 1927, 14623, 25627, 3742, 2687, 43, 1990, 23743, 17, 2719, 6497, 8358, 1922, 3615, 18, 12173, 3673, 1930, 2949, 2890, 15894, 2893, 3]}, "items": [{"id": "p_4303", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_4304", "content": "Isoproterenol [SEP]  histopathological examination of heart tissues were performed. Isoproterenol-treated rats showed significant increases in the levels of lact", "tokenized_content": [2, 23743, 3, 11777, 4981, 1927, 4003, 3878, 1985, 2593, 18, 23743, 17, 2868, 3615, 2594, 2228, 4041, 1922, 1920, 2428, 1927, 5641, 3]}, "items": [{"id": "p_4304", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_4305", "content": "lactate [SEP] enol-treated rats showed significant increases in the levels of lactate dehydrogenase, aspartate transaminase, creatine kinase and malo", "tokenized_content": [2, 9456, 3, 2066, 1945, 17, 2868, 3615, 2594, 2228, 4041, 1922, 1920, 2428, 1927, 9456, 9294, 16, 12878, 24376, 16, 17784, 4016, 1930, 3054, 1037, 3]}, "items": [{"id": "p_4305", "content": "Lactic Acid [SEP] A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent ", "score": 1, "type": null, "tokenized_content": [2, 16562, 2687, 3, 43, 2791, 6129, 1922, 1920, 12670, 12, 6638, 16, 4714, 13, 1927, 9523, 18, 1920, 9421, 2386, 1977, 2251, 23125, 1942, 4625, 3]}]}
{"query": {"id": "q_4306", "content": "aspartate [SEP] d significant increases in the levels of lactate dehydrogenase, aspartate transaminase, creatine kinase and malondialdehyde and significa", "tokenized_content": [2, 12878, 3, 46, 2228, 4041, 1922, 1920, 2428, 1927, 9456, 9294, 16, 12878, 24376, 16, 17784, 4016, 1930, 24270, 1930, 2208, 1019, 3]}, "items": [{"id": "p_4306", "content": "Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca", "score": 1, "type": null, "tokenized_content": [2, 23047, 2687, 3, 2340, 1927, 1920, 2447, 17, 4415, 3835, 4576, 5384, 6966, 1922, 1920, 54, 17, 2386, 18, 2176, 1977, 2435, 1922, 3555, 1930, 4793, 16, 4369, 1922, 9523, 2332, 3]}]}
{"query": {"id": "q_4307", "content": "creatine [SEP] in the levels of lactate dehydrogenase, aspartate transaminase, creatine kinase and malondialdehyde and significant decreases in the act", "tokenized_content": [2, 17784, 3, 1922, 1920, 2428, 1927, 9456, 9294, 16, 12878, 24376, 16, 17784, 4016, 1930, 24270, 1930, 2228, 6386, 1922, 1920, 4033, 3]}, "items": [{"id": "p_4307", "content": "Creatine [SEP] An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Cr", "score": 1, "type": null, "tokenized_content": [2, 17784, 3, 1925, 3835, 2687, 1988, 5110, 1922, 13416, 3878, 1930, 1922, 6960, 18, 1922, 3760, 2960, 16, 17784, 4933, 5110, 1966, 8078, 18662, 13905, 18, 2345, 3]}]}
{"query": {"id": "q_4308", "content": "malondialdehyde [SEP] tate dehydrogenase, aspartate transaminase, creatine kinase and malondialdehyde and significant decreases in the activities of superoxide dismu", "tokenized_content": [2, 24270, 3, 10687, 1021, 9294, 16, 12878, 24376, 16, 17784, 4016, 1930, 24270, 1930, 2228, 6386, 1922, 1920, 4209, 1927, 10738, 25529, 1032, 3]}, "items": [{"id": "p_4308", "content": "Malondialdehyde [SEP] The dialdehyde of malonic acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24270, 3, 1920, 7588, 6542, 1927, 3054, 3490, 2687, 18, 3]}]}
{"query": {"id": "q_4309", "content": "superoxide [SEP]  malondialdehyde and significant decreases in the activities of superoxide dismutase, catalase and glutathione peroxidase in serum and hea", "tokenized_content": [2, 10738, 3, 24270, 1930, 2228, 6386, 1922, 1920, 4209, 1927, 10738, 16679, 16, 14508, 1930, 9153, 9433, 1922, 3256, 1930, 2234, 1019, 3]}, "items": [{"id": "p_4309", "content": "Superoxides [SEP] Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated dur", "score": 1, "type": null, "tokenized_content": [2, 10738, 1036, 3, 3626, 6079, 4300, 4152, 2469, 4612, 1977, 3028, 2007, 43, 2957, 4995, 18, 1922, 3933, 3771, 16, 2611, 2278, 1998, 3999, 2335, 3]}]}
{"query": {"id": "q_4310", "content": "glutathione [SEP] creases in the activities of superoxide dismutase, catalase and glutathione peroxidase in serum and heart. These rats also showed declines ", "tokenized_content": [2, 9153, 3, 3478, 2319, 1922, 1920, 4209, 1927, 10738, 16679, 16, 14508, 1930, 9153, 9433, 1922, 3256, 1930, 4003, 18, 2144, 3615, 2222, 2594, 15459, 3]}, "items": [{"id": "p_4310", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_4311", "content": "respiratory dysfunction [SEP] d-diastolic pressure and ST-segment. In addition, mitochondrial respiratory dysfunction characterized by decreased respiratory control ratio and ADP/O ", "tokenized_content": [2, 5481, 5273, 3, 46, 17, 9395, 3772, 1930, 1955, 17, 5367, 18, 1922, 2459, 16, 4596, 5481, 5273, 4378, 2007, 3261, 5481, 2285, 3400, 1930, 9828, 19, 57, 3]}, "items": [{"id": "p_4311", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_4312", "content": "ADP [SEP] nction characterized by decreased respiratory control ratio and ADP/O was observed in isoproterenol-treated rats. Administration of", "tokenized_content": [2, 9828, 3, 10409, 2001, 4378, 2007, 3261, 5481, 2285, 3400, 1930, 9828, 19, 57, 1982, 2528, 1922, 23743, 17, 2868, 3615, 18, 4183, 1927, 3]}, "items": [{"id": "p_4312", "content": "Adenosine Diphosphate [SEP] Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at ", "score": 1, "type": null, "tokenized_content": [2, 10125, 23266, 3, 10125, 25, 11, 17, 12, 5083, 8535, 2432, 23266, 13, 18, 1925, 15643, 5489, 3165, 2288, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 2019, 3]}]}
{"query": {"id": "q_4313", "content": "cardiac dysfunction [SEP] period of 8 days significantly attenuated isoproterenol-induced cardiac dysfunction and myocardial injury and improved mitochondrial respiratory fu", "tokenized_content": [2, 4435, 5273, 3, 3047, 1927, 28, 3000, 2567, 8060, 23743, 17, 2719, 4435, 5273, 1930, 6497, 4047, 1930, 4305, 4596, 5481, 7391, 3]}, "items": [{"id": "p_4313", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_4314", "content": "myocardial injury [SEP] cantly attenuated isoproterenol-induced cardiac dysfunction and myocardial injury and improved mitochondrial respiratory function. The protective", "tokenized_content": [2, 6497, 4047, 3, 19895, 1954, 8060, 23743, 17, 2719, 4435, 5273, 1930, 6497, 4047, 1930, 4305, 4596, 5481, 2347, 18, 1920, 6337, 3]}, "items": [{"id": "p_4314", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_4315", "content": "myocardial damage [SEP] ective role of salvianolic acid A against isoproterenol-induced myocardial damage was further confirmed by histopathological examination. The res", "tokenized_content": [2, 6497, 4293, 3, 7495, 2320, 2770, 1927, 14623, 25627, 3742, 2687, 43, 3316, 23743, 17, 2719, 6497, 4293, 1982, 2520, 3982, 2007, 11777, 4981, 18, 1920, 1995, 3]}, "items": [{"id": "p_4315", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_4316", "content": "N-(2-propylpentanoyl)urea [SEP] Acute effects of N-(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-indu", "tokenized_content": [2, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 3, 3939, 2564, 1927, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 1990, 7636, 3835, 2687, 3]}, "items": [{"id": "p_4316", "content": "N-(2-propylpentanoyl)urea [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 3, 3]}]}
{"query": {"id": "q_4317", "content": "amino acid [SEP] Acute effects of N-(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats.", "tokenized_content": [2, 3835, 2687, 3, 3939, 2564, 1927, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 1990, 7636, 3835, 2687, 21012, 1922, 7547, 7095, 12184, 17, 2719, 11015, 1922, 3]}, "items": [{"id": "p_4317", "content": "Amino Acids [SEP] Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits", "score": 1, "type": null, "tokenized_content": [2, 3835, 4576, 3, 6805, 4300, 1988, 4933, 5531, 1925, 3835, 12, 17, 15410, 13, 1930, 43, 9943, 12, 17, 20729, 13, 2210, 18, 7639, 4595, 17, 3835, 4576, 2032, 1920, 6991, 3]}]}
{"query": {"id": "q_4318", "content": "pilocarpine [SEP] ylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats.", "tokenized_content": [2, 7547, 7095, 12184, 3, 12111, 17125, 3285, 10921, 13, 10505, 1990, 7636, 3835, 2687, 21012, 1922, 7547, 7095, 12184, 17, 2719, 11015, 1922, 3615, 18, 3]}, "items": [{"id": "p_4318", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_4319", "content": "seizure [SEP] hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats.", "tokenized_content": [2, 11015, 3, 7636, 3835, 2687, 21012, 1922, 7547, 7095, 12184, 17, 2719, 11015, 1922, 3615, 18, 3]}, "items": [{"id": "p_4319", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4320", "content": "amino acid [SEP] ant activity as well as the effects on the level of hippocampal amino acid neurotransmitters (glutamate, aspartate, glycine and GABA) of N", "tokenized_content": [2, 3835, 2687, 3, 4942, 2455, 1966, 2486, 1966, 1920, 2564, 1990, 1920, 2237, 1927, 7636, 3835, 2687, 21012, 12, 7627, 16, 12878, 16, 10646, 1930, 7992, 13, 1927, 56, 3]}, "items": [{"id": "p_4320", "content": "Amino Acids [SEP] Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits", "score": 1, "type": null, "tokenized_content": [2, 3835, 4576, 3, 6805, 4300, 1988, 4933, 5531, 1925, 3835, 12, 17, 15410, 13, 1930, 43, 9943, 12, 17, 20729, 13, 2210, 18, 7639, 4595, 17, 3835, 4576, 2032, 1920, 6991, 3]}]}
{"query": {"id": "q_4321", "content": "glutamate [SEP] fects on the level of hippocampal amino acid neurotransmitters (glutamate, aspartate, glycine and GABA) of N-(2-propylpentanoyl)urea (VPU", "tokenized_content": [2, 7627, 3, 16688, 1973, 1990, 1920, 2237, 1927, 7636, 3835, 2687, 21012, 12, 7627, 16, 12878, 16, 10646, 1930, 7992, 13, 1927, 56, 17, 12, 22, 17, 20299, 17125, 3285, 3]}, "items": [{"id": "p_4321", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_4322", "content": "aspartate [SEP] e level of hippocampal amino acid neurotransmitters (glutamate, aspartate, glycine and GABA) of N-(2-propylpentanoyl)urea (VPU) in compar", "tokenized_content": [2, 12878, 3, 47, 2237, 1927, 7636, 3835, 2687, 21012, 12, 7627, 16, 12878, 16, 10646, 1930, 7992, 13, 1927, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 3]}, "items": [{"id": "p_4322", "content": "Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca", "score": 1, "type": null, "tokenized_content": [2, 23047, 2687, 3, 2340, 1927, 1920, 2447, 17, 4415, 3835, 4576, 5384, 6966, 1922, 1920, 54, 17, 2386, 18, 2176, 1977, 2435, 1922, 3555, 1930, 4793, 16, 4369, 1922, 9523, 2332, 3]}]}
{"query": {"id": "q_4323", "content": "glycine [SEP] hippocampal amino acid neurotransmitters (glutamate, aspartate, glycine and GABA) of N-(2-propylpentanoyl)urea (VPU) in comparison to i", "tokenized_content": [2, 10646, 3, 7636, 3835, 2687, 21012, 12, 7627, 16, 12878, 16, 10646, 1930, 7992, 13, 1927, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 12, 9314, 1032, 3]}, "items": [{"id": "p_4323", "content": "Glycine [SEP] A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also", "score": 1, "type": null, "tokenized_content": [2, 10646, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 2176, 1977, 2435, 5985, 1922, 13200, 1930, 16947, 5094, 1921, 1930, 2251, 25058, 1966, 43, 8708, 18, 2176, 1977, 2222, 3]}]}
{"query": {"id": "q_4324", "content": "GABA [SEP] amino acid neurotransmitters (glutamate, aspartate, glycine and GABA) of N-(2-propylpentanoyl)urea (VPU) in comparison to its parent", "tokenized_content": [2, 7992, 3, 3835, 2687, 21012, 12, 7627, 16, 12878, 16, 10646, 1930, 7992, 13, 1927, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 12, 9314, 1032, 13, 3]}, "items": [{"id": "p_4324", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_4325", "content": "N-(2-propylpentanoyl)urea [SEP] d neurotransmitters (glutamate, aspartate, glycine and GABA) of N-(2-propylpentanoyl)urea (VPU) in comparison to its parent compound, valproic acid (VPA)", "tokenized_content": [2, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 3, 46, 21012, 12, 7627, 16, 12878, 16, 10646, 1930, 7992, 13, 1927, 56, 17, 12, 22, 17, 20299, 3]}, "items": [{"id": "p_4325", "content": "N-(2-propylpentanoyl)urea [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 3, 3]}]}
{"query": {"id": "q_4326", "content": "VPU [SEP] ate, aspartate, glycine and GABA) of N-(2-propylpentanoyl)urea (VPU) in comparison to its parent compound, valproic acid (VPA). VPU", "tokenized_content": [2, 9314, 1032, 3, 30280, 16, 12878, 16, 10646, 1930, 7992, 13, 1927, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 12, 9314, 1032, 13, 1922, 3723, 1942, 3]}, "items": [{"id": "p_4326", "content": "N-(2-propylpentanoyl)urea [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 12, 22, 17, 20299, 17125, 3285, 10921, 13, 10505, 3, 3]}]}
{"query": {"id": "q_4327", "content": "valproic acid [SEP] ropylpentanoyl)urea (VPU) in comparison to its parent compound, valproic acid (VPA). VPU was more potent than VPA, exhibiting the median effe", "tokenized_content": [2, 23867, 1935, 2687, 3, 17890, 2199, 17125, 3285, 10921, 13, 10505, 12, 9314, 1032, 13, 1922, 3723, 1942, 2496, 6162, 3547, 16, 23867, 1935, 2687, 12, 19703, 13, 18, 9314, 3]}, "items": [{"id": "p_4327", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_4328", "content": "VPA [SEP] urea (VPU) in comparison to its parent compound, valproic acid (VPA). VPU was more potent than VPA, exhibiting the median effective", "tokenized_content": [2, 19703, 3, 10505, 12, 9314, 1032, 13, 1922, 3723, 1942, 2496, 6162, 3547, 16, 23867, 1935, 2687, 12, 19703, 13, 18, 9314, 1032, 1982, 2253, 6828, 2254, 19703, 16, 12196, 3]}, "items": [{"id": "p_4328", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_4329", "content": "pilocarpine [SEP]  effective dose (ED(50)) of 49 mg/kg in protecting rats against pilocarpine-induced seizure whereas the corresponding value for VPA was 322", "tokenized_content": [2, 7547, 7095, 12184, 3, 3655, 3253, 12, 3347, 12, 2761, 13, 13, 1927, 4343, 2786, 19, 3621, 1922, 15145, 3615, 3316, 7547, 7095, 12184, 17, 2719, 11015, 3417, 1920, 3980, 3]}, "items": [{"id": "p_4329", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_4330", "content": "seizure [SEP] 50)) of 49 mg/kg in protecting rats against pilocarpine-induced seizure whereas the corresponding value for VPA was 322 mg/kg. In vivo ", "tokenized_content": [2, 11015, 3, 2761, 13, 13, 1927, 4343, 2786, 19, 3621, 1922, 15145, 3615, 3316, 7547, 7095, 12184, 17, 2719, 11015, 3417, 1920, 3980, 3113, 1958, 19703, 1982, 24734, 2786, 19, 3]}, "items": [{"id": "p_4330", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4331", "content": "hepatitis [SEP] Acute hepatitis attack after exposure to telithromycin.", "tokenized_content": [2, 7977, 3, 3939, 7977, 8926, 2256, 3395, 1942, 5202, 20402, 18, 3]}, "items": [{"id": "p_4331", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4332", "content": "telithromycin [SEP] Acute hepatitis attack after exposure to telithromycin.", "tokenized_content": [2, 5202, 20402, 3, 3939, 7977, 8926, 2256, 3395, 1942, 5202, 20402, 18, 3]}, "items": [{"id": "p_4332", "content": "telithromycin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5202, 20402, 3, 3]}]}
{"query": {"id": "q_4333", "content": "hepatotoxicity [SEP] INTRODUCTION: Antibiotic-associated hepatotoxicity is rare. With widespread use of antimicrobial agents, however, ", "tokenized_content": [2, 24126, 3, 6935, 30, 7267, 17, 2458, 24126, 1977, 5844, 18, 1956, 9360, 2485, 1927, 8003, 4820, 16, 2406, 16, 3]}, "items": [{"id": "p_4333", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4334", "content": "hepatic injury [SEP]  is rare. With widespread use of antimicrobial agents, however, hepatic injury occurs frequently, and among adverse drug reactions, idiosyncra", "tokenized_content": [2, 6095, 4047, 3, 1977, 5844, 18, 1956, 9360, 2485, 1927, 8003, 4820, 16, 2406, 16, 6095, 4047, 5110, 5467, 16, 1930, 2706, 5246, 2838, 5298, 16, 11407, 23354, 2145, 1019, 3]}, "items": [{"id": "p_4334", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4335", "content": "adverse drug reactions [SEP] al agents, however, hepatic injury occurs frequently, and among adverse drug reactions, idiosyncratic reactions are the most serious. CASE SUMMARY: A ", "tokenized_content": [2, 5246, 2838, 5298, 3, 1969, 4820, 16, 2406, 16, 6095, 4047, 5110, 5467, 16, 1930, 2706, 5246, 2838, 5298, 16, 11407, 23354, 2145, 2479, 5298, 2032, 1920, 2501, 7433, 18, 3]}, "items": [{"id": "p_4335", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4336", "content": "jaundice [SEP] Emergency Department, Istanbul, Turkey, with 5 days' history of jaundice, malaise, nausea, and vomiting. He had been prescribed telithro", "tokenized_content": [2, 25314, 3, 7877, 6143, 16, 1977, 3285, 17909, 1024, 16, 18383, 16, 1956, 25, 3000, 11, 4403, 1927, 25314, 16, 3054, 5504, 4127, 16, 13759, 16, 1930, 13954, 18, 2234, 3]}, "items": [{"id": "p_4336", "content": "Jaundice [SEP] A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA", "score": 1, "type": null, "tokenized_content": [2, 25314, 3, 43, 2535, 15570, 1927, 4194, 12039, 14560, 3847, 16, 4378, 2007, 1920, 7463, 2471, 4166, 1927, 1920, 4407, 31, 27103, 3260, 31, 1930, 8266, 1019, 3]}]}
{"query": {"id": "q_4337", "content": "nausea [SEP] t, Istanbul, Turkey, with 5 days' history of jaundice, malaise, nausea, and vomiting. He had been prescribed telithromycin 400 mg/d PO", "tokenized_content": [2, 13759, 3, 62, 16, 1977, 3285, 17909, 1024, 16, 18383, 16, 1956, 25, 3000, 11, 4403, 1927, 25314, 16, 3054, 5504, 4127, 16, 13759, 16, 1930, 13954, 18, 2234, 2430, 3]}, "items": [{"id": "p_4337", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_4338", "content": "vomiting [SEP]  Turkey, with 5 days' history of jaundice, malaise, nausea, and vomiting. He had been prescribed telithromycin 400 mg/d PO to treat an u", "tokenized_content": [2, 13954, 3, 18383, 16, 1956, 25, 3000, 11, 4403, 1927, 25314, 16, 3054, 5504, 4127, 16, 13759, 16, 1930, 13954, 18, 2234, 2430, 2252, 9975, 5202, 20402, 5805, 2786, 19, 3]}, "items": [{"id": "p_4338", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_4339", "content": "telithromycin [SEP] jaundice, malaise, nausea, and vomiting. He had been prescribed telithromycin 400 mg/d PO to treat an upper respiratory tract infection 7 day", "tokenized_content": [2, 5202, 20402, 3, 25314, 16, 3054, 5504, 4127, 16, 13759, 16, 1930, 13954, 18, 2234, 2430, 2252, 9975, 5202, 20402, 5805, 2786, 19, 46, 2510, 1942, 2297, 1925, 5199, 5481, 3]}, "items": [{"id": "p_4339", "content": "telithromycin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5202, 20402, 3, 3]}]}
{"query": {"id": "q_4340", "content": "upper respiratory tract infection [SEP] g. He had been prescribed telithromycin 400 mg/d PO to treat an upper respiratory tract infection 7 days prior. Admission laboratory tests were as follows: alani", "tokenized_content": [2, 5199, 5481, 6482, 2909, 3, 49, 18, 2234, 2430, 2252, 9975, 5202, 20402, 5805, 2786, 19, 46, 2510, 1942, 2297, 1925, 5199, 5481, 6482, 2909, 27, 3000, 3432, 18, 7682, 3]}, "items": [{"id": "p_4340", "content": "Respiratory Tract Infections [SEP] Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 6482, 5024, 3, 6254, 1927, 1920, 4423, 5481, 2433, 2007, 11679, 16, 5394, 4523, 1942, 6598, 4028, 2014, 3902, 18, 3]}]}
{"query": {"id": "q_4341", "content": "alanine [SEP] ction 7 days prior. Admission laboratory tests were as follows: alanine aminotransferase, 67 U/L (reference range, 10-37 U/L); aspartat", "tokenized_content": [2, 10504, 3, 3369, 2001, 27, 3000, 3432, 18, 7682, 4542, 4026, 1985, 1966, 6052, 30, 10504, 15817, 16, 4838, 63, 19, 54, 12, 4386, 3109, 16, 2119, 17, 3191, 63, 3]}, "items": [{"id": "p_4341", "content": "Alanine [SEP] A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transaminatio", "score": 1, "type": null, "tokenized_content": [2, 10504, 3, 43, 2447, 17, 4415, 3835, 2687, 1988, 5110, 1922, 2149, 2428, 1922, 2496, 3294, 3360, 1922, 3582, 18, 2176, 1977, 4152, 2037, 11867, 2007, 2127, 3717, 1968, 1037, 3]}]}
{"query": {"id": "q_4342", "content": "aspartate [SEP]  alanine aminotransferase, 67 U/L (reference range, 10-37 U/L); aspartate aminotransferase, 98 U/L (10-40 U/L); alkaline phosphatase, 513", "tokenized_content": [2, 12878, 3, 10504, 15817, 16, 4838, 63, 19, 54, 12, 4386, 3109, 16, 2119, 17, 3191, 63, 19, 54, 13, 31, 12878, 15817, 16, 5613, 63, 19, 54, 12, 2119, 3]}, "items": [{"id": "p_4342", "content": "Aspartic Acid [SEP] One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar ca", "score": 1, "type": null, "tokenized_content": [2, 23047, 2687, 3, 2340, 1927, 1920, 2447, 17, 4415, 3835, 4576, 5384, 6966, 1922, 1920, 54, 17, 2386, 18, 2176, 1977, 2435, 1922, 3555, 1930, 4793, 16, 4369, 1922, 9523, 2332, 3]}]}
{"query": {"id": "q_4343", "content": "bilirubin [SEP] nsferase, 32 U/L (7-49 U/L); amylase, 46 U/L (0-220 U/L); total bilirubin, 20.1 mg/dL (0.2-1.0 mg/dL); direct bilirubin, 14.8 mg/dL (0-0.", "tokenized_content": [2, 15702, 3, 21449, 7124, 4127, 16, 3323, 63, 19, 54, 12, 27, 17, 4343, 63, 19, 54, 13, 31, 19139, 16, 4182, 63, 19, 54, 12, 20, 17, 12391, 63, 3]}, "items": [{"id": "p_4343", "content": "Bilirubin [SEP] A bile pigment that is a degradation product of HEME.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15702, 3, 43, 9619, 12905, 1988, 1977, 43, 4877, 4863, 1927, 10954, 18, 3]}]}
{"query": {"id": "q_4344", "content": "alcohol [SEP] 0-0.3 mg/dL); and albumin, 4.7 mg/dL (3.5-5.4 mg/dL). No toxin, alcohol, or other drugs were reported. The patient had suffered a previ", "tokenized_content": [2, 4284, 3, 20, 17, 20, 18, 23, 2786, 19, 5268, 13, 31, 1930, 7712, 16, 24, 18, 27, 2786, 19, 5268, 12, 23, 18, 25, 17, 25, 18, 24, 2786, 3]}, "items": [{"id": "p_4344", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_4345", "content": "hepatitis [SEP] reported. The patient had suffered a previous episode of \"acute hepatitis of unknown origin,\" that occurred after telithromycin usage. Bo", "tokenized_content": [2, 7977, 3, 2568, 18, 1920, 2774, 2430, 13949, 43, 2555, 11631, 1927, 6, 3939, 7977, 1927, 5435, 4853, 16, 6, 1988, 4807, 2256, 5202, 20402, 10070, 18, 4078, 3]}, "items": [{"id": "p_4345", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4346", "content": "Telithromycin [SEP] mycin usage. Both incidents occurred within a year. DISCUSSION: Telithromycin is the first of the ketolide antibacterials to receive US Food ", "tokenized_content": [2, 5202, 20402, 3, 5078, 1921, 10070, 18, 2321, 23564, 4807, 2651, 43, 2476, 18, 7248, 30, 5202, 20402, 1977, 1920, 2561, 1927, 1920, 21471, 12191, 3695, 13021, 1036, 1942, 7130, 3]}, "items": [{"id": "p_4346", "content": "telithromycin [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 5202, 20402, 3, 3]}]}
{"query": {"id": "q_4347", "content": "hepatic dysfunction [SEP] s been associated with infrequent and usually reversible severe hepatic dysfunction. Based on a score of 8 on the Naranjo adverse drug reaction pro", "tokenized_content": [2, 6095, 5273, 3, 61, 2252, 2458, 1956, 21587, 1930, 5394, 10743, 4010, 6095, 5273, 18, 2454, 1990, 43, 3593, 1927, 28, 1990, 1920, 7612, 1928, 15064, 5246, 2838, 3227, 1965, 3]}, "items": [{"id": "p_4347", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_4348", "content": "adverse drug reaction [SEP] al agents, however, hepatic injury occurs frequently, and among adverse drug reactions, idiosyncratic reactions are the most serious. CASE SUMMARY: A", "tokenized_content": [2, 5246, 2838, 3227, 3, 1969, 4820, 16, 2406, 16, 6095, 4047, 5110, 5467, 16, 1930, 2706, 5246, 2838, 5298, 16, 11407, 23354, 2145, 2479, 5298, 2032, 1920, 2501, 7433, 18, 3]}, "items": [{"id": "p_4348", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4349", "content": "toxic hepatitis [SEP]  this patient, and pathological findings suggested drug-induced toxic hepatitis. Recurrence of hepatitis attack might have been avoided if the ", "tokenized_content": [2, 6161, 7977, 3, 2052, 2774, 16, 1930, 6598, 3056, 3978, 2838, 17, 2719, 6161, 7977, 18, 6339, 1927, 7977, 8926, 3284, 2162, 2252, 14329, 2647, 1920, 3]}, "items": [{"id": "p_4349", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4350", "content": "Spironolactone [SEP] Spironolactone-induced renal insufficiency and hyperkalemia in patients with h", "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 22075, 11873, 5148, 2341, 2290, 17, 2719, 4604, 14566, 1930, 4194, 7640, 1952, 6026, 1922, 2132, 1956, 50, 3]}, "items": [{"id": "p_4350", "content": "Spironolactone [SEP] A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatm", "score": 1, "type": null, "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 43, 9057, 17981, 26829, 1988, 8016, 2007, 18394, 1927, 16944, 1922, 1920, 6583, 4604, 14876, 18, 2176, 1977, 2251, 4994, 1922, 1920, 2297, 1035, 3]}]}
{"query": {"id": "q_4351", "content": "renal insufficiency [SEP] Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure.", "tokenized_content": [2, 4604, 14566, 3, 22075, 11873, 5148, 2341, 2290, 17, 2719, 4604, 14566, 1930, 4194, 7640, 1952, 6026, 1922, 2132, 1956, 4003, 4574, 18, 3]}, "items": [{"id": "p_4351", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4352", "content": "hyperkalemia [SEP] Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure.", "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 22075, 11873, 5148, 2341, 2290, 17, 2719, 4604, 14566, 1930, 4194, 7640, 1952, 6026, 1922, 2132, 1956, 4003, 4574, 18, 3]}, "items": [{"id": "p_4352", "content": "Hyperkalemia [SEP] Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinicall", "score": 1, "type": null, "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 20756, 2149, 9057, 3110, 1922, 1920, 2877, 16, 2501, 3868, 2810, 1942, 9785, 4604, 11093, 18, 2176, 1977, 4378, 2535, 1024, 3]}]}
{"query": {"id": "q_4353", "content": "heart failure [SEP] e-induced renal insufficiency and hyperkalemia in patients with heart failure.", "tokenized_content": [2, 4003, 4574, 3, 47, 17, 2719, 4604, 14566, 1930, 4194, 7640, 1952, 6026, 1922, 2132, 1956, 4003, 4574, 18, 3]}, "items": [{"id": "p_4353", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4354", "content": "spironolactone [SEP] D: A previous randomized controlled trial evaluating the use of spironolactone in heart failure patients reported a low risk of hyperkalemia (", "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 46, 30, 43, 2555, 5542, 4642, 3046, 8211, 1920, 2485, 1927, 22075, 11873, 5148, 2341, 2290, 1922, 4003, 4574, 2132, 2568, 43, 2330, 2565, 3]}, "items": [{"id": "p_4354", "content": "Spironolactone [SEP] A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatm", "score": 1, "type": null, "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 43, 9057, 17981, 26829, 1988, 8016, 2007, 18394, 1927, 16944, 1922, 1920, 6583, 4604, 14876, 18, 2176, 1977, 2251, 4994, 1922, 1920, 2297, 1035, 3]}]}
{"query": {"id": "q_4355", "content": "heart failure [SEP] omized controlled trial evaluating the use of spironolactone in heart failure patients reported a low risk of hyperkalemia (2%) and renal ins", "tokenized_content": [2, 4003, 4574, 3, 7254, 2301, 4642, 3046, 8211, 1920, 2485, 1927, 22075, 11873, 5148, 2341, 2290, 1922, 4003, 4574, 2132, 2568, 43, 2330, 2565, 1927, 4194, 7640, 1952, 6026, 12, 3]}, "items": [{"id": "p_4355", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4356", "content": "hyperkalemia [SEP] spironolactone in heart failure patients reported a low risk of hyperkalemia (2%) and renal insufficiency (0%). Because treatments for heart", "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 22075, 11873, 5148, 2341, 2290, 1922, 4003, 4574, 2132, 2568, 43, 2330, 2565, 1927, 4194, 7640, 1952, 6026, 12, 22, 9, 13, 1930, 4604, 14566, 3]}, "items": [{"id": "p_4356", "content": "Hyperkalemia [SEP] Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinicall", "score": 1, "type": null, "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 20756, 2149, 9057, 3110, 1922, 1920, 2877, 16, 2501, 3868, 2810, 1942, 9785, 4604, 11093, 18, 2176, 1977, 4378, 2535, 1024, 3]}]}
{"query": {"id": "q_4357", "content": "renal insufficiency [SEP] t failure patients reported a low risk of hyperkalemia (2%) and renal insufficiency (0%). Because treatments for heart failure have changed since t", "tokenized_content": [2, 4604, 14566, 3, 62, 4574, 2132, 2568, 43, 2330, 2565, 1927, 4194, 7640, 1952, 6026, 12, 22, 9, 13, 1930, 4604, 14566, 12, 20, 9, 13, 18, 2882, 4930, 1958, 3]}, "items": [{"id": "p_4357", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4358", "content": "K [SEP] BACKGROUND: A previous randomized controlled trial evaluating the us", "tokenized_content": [2, 53, 3, 3872, 30, 43, 2555, 5542, 4642, 3046, 8211, 1920, 2022, 3]}, "items": [{"id": "p_4358", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_4359", "content": "Cr [SEP] eveloped hyperkalemia (K(+) >5.0 mEq/L) or renal insufficiency (Cr >or=2.5 mg/dL), and they were compared to 2 randomly selected c", "tokenized_content": [2, 2345, 3, 2180, 1938, 4907, 1007, 4194, 7640, 1952, 6026, 12, 53, 12, 15, 13, 34, 25, 18, 20, 25509, 19, 54, 13, 2014, 4604, 14566, 12, 2345, 34, 2014, 3]}, "items": [{"id": "p_4359", "content": "Chromium [SEP] A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. Ac", "score": 1, "type": null, "tokenized_content": [2, 23536, 3, 43, 9950, 6149, 1988, 5705, 43, 2770, 1922, 3817, 4714, 18, 2176, 2258, 1920, 11241, 17530, 2345, 16, 11241, 2529, 2686, 16, 1930, 11241, 3388, 4764, 18, 2000, 3]}]}
{"query": {"id": "q_4360", "content": "renal failure [SEP] scontinuation of spironolactone due to hyperkalemia (n = 33) or renal failure (n = 34). Patients who developed hyperkalemia were older and mo", "tokenized_content": [2, 4604, 4574, 3, 2160, 7562, 10874, 1927, 22075, 11873, 5148, 2341, 2290, 2810, 1942, 4194, 7640, 1952, 6026, 12, 56, 33, 3401, 13, 2014, 4604, 4574, 12, 56, 33, 3540, 3]}, "items": [{"id": "p_4360", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4361", "content": "diabetes [SEP] s who developed hyperkalemia were older and more likely to have diabetes, had higher baseline serum potassium levels and lower baseline ", "tokenized_content": [2, 4032, 3, 61, 2746, 3530, 4194, 7640, 1952, 6026, 1985, 4706, 1930, 2253, 3205, 1942, 2162, 4032, 16, 2430, 2580, 3703, 3256, 9057, 2428, 1930, 2826, 3703, 3]}, "items": [{"id": "p_4361", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_4362", "content": "potassium [SEP] der and more likely to have diabetes, had higher baseline serum potassium levels and lower baseline potassium supplement doses, and were ", "tokenized_content": [2, 9057, 3, 3135, 1930, 2253, 3205, 1942, 2162, 4032, 16, 2430, 2580, 3703, 3256, 9057, 2428, 1930, 2826, 3703, 9057, 3029, 5312, 16, 1930, 1985, 3]}, "items": [{"id": "p_4362", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_4363", "content": "creatinine [SEP] ciency had lower baseline body weight and higher baseline serum creatinine, required higher doses of loop diuretics, and were more likely ", "tokenized_content": [2, 9374, 3, 3371, 2589, 2430, 2826, 3703, 3362, 3388, 1930, 2580, 3703, 3256, 9374, 16, 3414, 2580, 5312, 1927, 5881, 25505, 16, 1930, 1985, 2253, 3205, 3]}, "items": [{"id": "p_4363", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_4364", "content": "thiazide [SEP] oses of loop diuretics, and were more likely to be treated with thiazide diuretics than controls. CONCLUSIONS: Spironolactone-induced hy", "tokenized_content": [2, 27225, 2261, 3, 3125, 1918, 1927, 5881, 25505, 16, 1930, 1985, 2253, 3205, 1942, 1998, 2868, 1956, 27225, 2261, 25505, 2254, 3562, 18, 4355, 30, 22075, 11873, 5148, 2341, 2290, 3]}, "items": [{"id": "p_4364", "content": "Thiazides [SEP] Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SOD", "score": 1, "type": null, "tokenized_content": [2, 27225, 3726, 3, 27804, 13153, 4300, 1956, 12585, 1930, 6634, 1922, 1920, 6335, 18, 2052, 2576, 5384, 11238, 1942, 1920, 19225, 22523, 2713, 10119, 1036, 1988, 2875, 4546, 3]}]}
{"query": {"id": "q_4365", "content": "Spironolactone [SEP]  be treated with thiazide diuretics than controls. CONCLUSIONS: Spironolactone-induced hyperkalemia and renal insufficiency are more common in", "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 1998, 2868, 1956, 27225, 2261, 25505, 2254, 3562, 18, 4355, 30, 22075, 11873, 5148, 2341, 2290, 17, 2719, 4194, 7640, 1952, 6026, 1930, 4604, 3]}, "items": [{"id": "p_4365", "content": "Spironolactone [SEP] A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatm", "score": 1, "type": null, "tokenized_content": [2, 22075, 11873, 5148, 2341, 2290, 3, 43, 9057, 17981, 26829, 1988, 8016, 2007, 18394, 1927, 16944, 1922, 1920, 6583, 4604, 14876, 18, 2176, 1977, 2251, 4994, 1922, 1920, 2297, 1035, 3]}]}
{"query": {"id": "q_4366", "content": "End-stage renal disease [SEP] End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calc", "tokenized_content": [2, 2482, 17, 3587, 4604, 2573, 3, 2482, 17, 3587, 4604, 2573, 12, 17070, 13, 2256, 21306, 3568, 6530, 12, 2865, 29437, 13, 2193, 2799, 3]}, "items": [{"id": "p_4366", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_4367", "content": "ESRD [SEP] End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineuri", "tokenized_content": [2, 17070, 3, 2482, 17, 3587, 4604, 2573, 12, 17070, 13, 2256, 21306, 3568, 6530, 12, 2865, 29437, 13, 2193, 19504, 18330, 3]}, "items": [{"id": "p_4367", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_4368", "content": "cyclosporine [SEP] BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in o", "tokenized_content": [2, 21002, 3, 3872, 30, 1920, 19555, 4472, 21002, 1930, 21801, 2032, 2321, 3171, 1942, 1998, 22994, 10605, 18, 2310, 2485, 1922, 57, 3]}, "items": [{"id": "p_4368", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4369", "content": "tacrolimus [SEP] BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver", "tokenized_content": [2, 21801, 3, 3872, 30, 1920, 19555, 4472, 21002, 1930, 21801, 2032, 2321, 3171, 1942, 1998, 22994, 10605, 18, 2310, 2485, 1922, 21306, 3568, 3]}, "items": [{"id": "p_4369", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4370", "content": "nephrotoxic [SEP] rin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has drama", "tokenized_content": [2, 22994, 10605, 3, 25699, 4472, 21002, 1930, 21801, 2032, 2321, 3171, 1942, 1998, 22994, 10605, 18, 2310, 2485, 1922, 21306, 3568, 6530, 12, 2865, 29437, 13, 2258, 7287, 1019, 3]}, "items": [{"id": "p_4370", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4371", "content": "end-stage renal disease [SEP]  had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). This retrospective study examines the incidence and tre", "tokenized_content": [2, 2482, 17, 3587, 4604, 2573, 3, 2430, 1925, 2760, 1927, 2132, 2746, 2032, 8326, 2256, 2865, 29437, 1956, 2482, 17, 3587, 4604, 2573, 12, 17070, 13, 18, 2052, 6968, 2161, 3]}, "items": [{"id": "p_4371", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_4372", "content": "ESRD [SEP] nts who are presenting after OLTX with end-stage renal disease (ESRD). This retrospective study examines the incidence and treatment", "tokenized_content": [2, 17070, 3, 17969, 2746, 2032, 8326, 2256, 2865, 29437, 1956, 2482, 17, 3587, 4604, 2573, 12, 17070, 13, 18, 2052, 6968, 2161, 17910, 1920, 4332, 1930, 2311, 3]}, "items": [{"id": "p_4372", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_4373", "content": "chronic renal failure [SEP] spective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients. METHODS: Patients receiving an OLTX onl", "tokenized_content": [2, 3724, 4604, 4574, 3, 4544, 2320, 2161, 17910, 1920, 4332, 1930, 2311, 1927, 17070, 1930, 3724, 4604, 4574, 12, 14006, 13, 1922, 2865, 29437, 2132, 18, 2860, 30, 2132, 5962, 3]}, "items": [{"id": "p_4373", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_4374", "content": "CRF [SEP]  the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients. METHODS: Patients receiving an OLTX only fro", "tokenized_content": [2, 14006, 3, 1920, 4332, 1930, 2311, 1927, 17070, 1930, 3724, 4604, 4574, 12, 14006, 13, 1922, 2865, 29437, 2132, 18, 2860, 30, 2132, 5962, 1925, 2865, 29437, 2444, 7542, 3]}, "items": [{"id": "p_4374", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_4375", "content": "creatinine [SEP] e groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. Groups were compared for preo", "tokenized_content": [2, 9374, 3, 47, 2671, 30, 3562, 16, 2239, 14006, 2014, 17070, 16, 56, 33, 5446, 1025, 31, 14006, 16, 7637, 3256, 9374, 34, 22, 18, 25, 2786, 19, 5268, 16, 3]}, "items": [{"id": "p_4375", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_4376", "content": "renal dysfunction [SEP]  ESRD. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%). Compared with control patie", "tokenized_content": [2, 4604, 5273, 3, 17070, 18, 2274, 30, 2019, 2590, 2739, 2256, 2865, 29437, 16, 1920, 4332, 1927, 4010, 4604, 5273, 1982, 2654, 18, 21, 9, 12, 14006, 28, 18, 26, 3]}, "items": [{"id": "p_4376", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4377", "content": "hepatorenal syndrome [SEP]  serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 mont", "tokenized_content": [2, 5746, 2073, 3163, 4741, 3, 3256, 9374, 2428, 16, 43, 3430, 4466, 1927, 2132, 1956, 5746, 2073, 3163, 4741, 16, 2580, 4466, 8853, 1958, 9787, 1922, 1920, 2561, 23, 20191, 3]}, "items": [{"id": "p_4377", "content": "Hepatorenal Syndrome [SEP] Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL),", "score": 1, "type": null, "tokenized_content": [2, 5746, 2073, 3163, 4741, 3, 3183, 5245, 4574, 1922, 2132, 1956, 3568, 2573, 16, 5394, 3568, 11260, 2014, 10669, 5579, 12, 5579, 16, 10669, 13, 16, 3]}]}
{"query": {"id": "q_4378", "content": "nimodipine [SEP] Effect of intravenous nimodipine on blood pressure and outcome after acute stroke.", "tokenized_content": [2, 17709, 26584, 3, 2495, 1927, 7307, 17709, 26584, 1990, 2877, 3772, 1930, 3924, 2256, 3939, 5235, 18, 3]}, "items": [{"id": "p_4378", "content": "Nimodipine [SEP] A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lower", "score": 1, "type": null, "tokenized_content": [2, 17709, 26584, 3, 43, 5016, 4999, 9847, 1005, 1956, 15069, 16221, 2455, 18, 2176, 2258, 4961, 16221, 4333, 2287, 2564, 1930, 2826, 3]}]}
{"query": {"id": "q_4379", "content": "acute stroke [SEP] t of intravenous nimodipine on blood pressure and outcome after acute stroke.", "tokenized_content": [2, 3939, 5235, 3, 62, 1927, 7307, 17709, 26584, 1990, 2877, 3772, 1930, 3924, 2256, 3939, 5235, 18, 3]}, "items": [{"id": "p_4379", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_4380", "content": "Nimodipine [SEP] BACKGROUND AND PURPOSE: The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between", "tokenized_content": [2, 17709, 26584, 3, 3872, 1930, 5120, 30, 1920, 7307, 17709, 26584, 9195, 6785, 5235, 3046, 12, 1922, 18959, 13, 2435, 43, 3670, 2192, 3]}, "items": [{"id": "p_4380", "content": "Nimodipine [SEP] A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lower", "score": 1, "type": null, "tokenized_content": [2, 17709, 26584, 3, 43, 5016, 4999, 9847, 1005, 1956, 15069, 16221, 2455, 18, 2176, 2258, 4961, 16221, 4333, 2287, 2564, 1930, 2826, 3]}]}
{"query": {"id": "q_4381", "content": "Stroke [SEP] ACKGROUND AND PURPOSE: The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between nimodipine-induced r", "tokenized_content": [2, 5235, 3, 2000, 23254, 3049, 1930, 5120, 30, 1920, 7307, 17709, 26584, 9195, 6785, 5235, 3046, 12, 1922, 18959, 13, 2435, 43, 3670, 2192, 17709, 26584, 17, 2719, 60, 3]}, "items": [{"id": "p_4381", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_4382", "content": "nimodipine [SEP] West European Stroke Trial (INWEST) found a correlation between nimodipine-induced reduction in blood pressure (BP) and an unfavorable out", "tokenized_content": [2, 17709, 26584, 3, 9195, 6785, 5235, 3046, 12, 1922, 18959, 13, 2435, 43, 3670, 2192, 17709, 26584, 17, 2719, 3378, 1922, 2877, 3772, 12, 4149, 13, 1930, 1925, 16839, 2397, 3]}, "items": [{"id": "p_4382", "content": "Nimodipine [SEP] A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lower", "score": 1, "type": null, "tokenized_content": [2, 17709, 26584, 3, 43, 5016, 4999, 9847, 1005, 1956, 15069, 16221, 2455, 18, 2176, 2258, 4961, 16221, 4333, 2287, 2564, 1930, 2826, 3]}]}
{"query": {"id": "q_4383", "content": "reduction in blood pressure [SEP] e Trial (INWEST) found a correlation between nimodipine-induced reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to c", "tokenized_content": [2, 3378, 1922, 2877, 3772, 3, 47, 3046, 12, 1922, 18959, 13, 2435, 43, 3670, 2192, 17709, 26584, 17, 2719, 3378, 1922, 2877, 3772, 12, 4149, 13, 1930, 1925, 16839, 3924, 3]}, "items": [{"id": "p_4383", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4384", "content": "acute stroke [SEP]  reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to confirm this correlation with and without adjustm", "tokenized_content": [2, 3939, 5235, 3, 3378, 1922, 2877, 3772, 12, 4149, 13, 1930, 1925, 16839, 3924, 1922, 3939, 5235, 18, 2038, 8758, 1942, 4763, 2052, 3670, 1956, 1930, 2979, 6278, 1035, 3]}, "items": [{"id": "p_4384", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_4385", "content": "BP reduction [SEP] d to investigate outcome in subgroups with increasing levels of BP reduction. METHODS: Patients with a clinical diagnosis of ischemic stroke", "tokenized_content": [2, 4149, 3378, 3, 46, 1942, 4482, 3924, 1922, 9161, 1956, 3605, 2428, 1927, 4149, 3378, 18, 2860, 30, 2132, 1956, 43, 2535, 3574, 1927, 7427, 5235, 3]}, "items": [{"id": "p_4385", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4386", "content": "ischemic stroke [SEP] of BP reduction. METHODS: Patients with a clinical diagnosis of ischemic stroke (within 24 hours) were consecutively allocated to receive place", "tokenized_content": [2, 7427, 5235, 3, 1927, 4149, 3378, 18, 2860, 30, 2132, 1956, 43, 2535, 3574, 1927, 7427, 5235, 12, 2651, 2686, 3967, 13, 1985, 22304, 14553, 1942, 7130, 4368, 3]}, "items": [{"id": "p_4386", "content": "Cerebral Infarction [SEP] The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of th", "score": 1, "type": null, "tokenized_content": [2, 6329, 8358, 3, 1920, 3337, 1927, 1925, 3403, 1927, 7476, 1922, 1920, 6626, 24277, 4189, 2007, 1925, 14566, 1927, 6624, 2014, 8562, 2877, 3426, 18, 28701, 1927, 1913, 3]}]}
{"query": {"id": "q_4387", "content": "reduction in systolic BP [SEP] ). Nimodipine treatment resulted in a statistically significant reduction in systolic BP (SBP) and diastolic BP (DBP) from baseline compared with placeb", "tokenized_content": [2, 3378, 1922, 8541, 4149, 3, 13, 18, 17709, 26584, 2311, 4306, 1922, 43, 4388, 2228, 3378, 1922, 8541, 4149, 12, 12345, 13, 1930, 9395, 4149, 12, 14473, 13, 2037, 3703, 3]}, "items": [{"id": "p_4387", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4388", "content": "DBP reduction [SEP] ys. In multivariate analysis, a significant correlation between DBP reduction and worsening of the neurological score was found for the high-", "tokenized_content": [2, 14473, 3378, 3, 24018, 18, 1922, 6884, 2333, 16, 43, 2228, 3670, 2192, 14473, 3378, 1930, 15473, 1927, 1920, 7605, 3593, 1982, 2435, 1958, 1920, 2149, 17, 3]}, "items": [{"id": "p_4388", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4389", "content": "death [SEP] icantly increased adjusted OR for the compound outcome variable death or dependency (Barthel Index <60) (n/N=25/26, OR 10. 16, 95% CI", "tokenized_content": [2, 3539, 3, 14784, 4905, 1954, 2502, 4967, 2014, 1958, 1920, 3547, 3924, 4650, 3539, 2014, 14604, 12, 30209, 1938, 3867, 32, 3276, 13, 12, 56, 19, 56, 33, 2637, 19, 3]}, "items": [{"id": "p_4389", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_4390", "content": "Transient neurologic symptoms [SEP] Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and ", "tokenized_content": [2, 6809, 14314, 3601, 3, 6809, 14314, 3601, 2256, 6071, 8871, 30, 43, 2826, 4332, 1956, 17618, 6012, 3375, 2053, 1930, 3]}, "items": [{"id": "p_4390", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4391", "content": "prilocaine [SEP] ologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine.", "tokenized_content": [2, 17618, 6012, 3375, 2053, 3, 2865, 2021, 1935, 3601, 2256, 6071, 8871, 30, 43, 2826, 4332, 1956, 17618, 6012, 3375, 2053, 1930, 25473, 2254, 1956, 19567, 18, 3]}, "items": [{"id": "p_4391", "content": "Prilocaine [SEP] A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia ", "score": 1, "type": null, "tokenized_content": [2, 17618, 6012, 3375, 2053, 3, 43, 3076, 16111, 1988, 1977, 2551, 24645, 1942, 19567, 18, 5077, 16, 2176, 1977, 2251, 2501, 3868, 1958, 8946, 8871, 3]}]}
{"query": {"id": "q_4392", "content": "bupivacaine [SEP]  after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine.", "tokenized_content": [2, 25473, 3, 2256, 6071, 8871, 30, 43, 2826, 4332, 1956, 17618, 6012, 3375, 2053, 1930, 25473, 2254, 1956, 19567, 18, 3]}, "items": [{"id": "p_4392", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_4393", "content": "lidocaine [SEP] ia: a lower incidence with prilocaine and bupivacaine than with lidocaine.", "tokenized_content": [2, 19567, 3, 11640, 30, 43, 2826, 4332, 1956, 17618, 6012, 3375, 2053, 1930, 25473, 2254, 1956, 19567, 18, 3]}, "items": [{"id": "p_4393", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_4394", "content": "transient neurologic symptoms [SEP] BACKGROUND: Recent evidence suggests that transient neurologic symptoms (TNSs) frequently follow lidocaine spinal anesthesia but are in", "tokenized_content": [2, 6809, 14314, 3601, 3, 3872, 30, 3505, 3095, 4015, 1988, 6809, 14314, 3601, 12, 7417, 5590, 13, 5467, 2396, 19567, 6071, 8871, 2308, 2032, 1922, 3]}, "items": [{"id": "p_4394", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4395", "content": "TNSs [SEP] D: Recent evidence suggests that transient neurologic symptoms (TNSs) frequently follow lidocaine spinal anesthesia but are infreque", "tokenized_content": [2, 7417, 5590, 3, 46, 30, 3505, 3095, 4015, 1988, 6809, 14314, 3601, 12, 7417, 5590, 13, 5467, 2396, 19567, 6071, 8871, 2308, 2032, 17047, 1021, 3]}, "items": [{"id": "p_4395", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4396", "content": "lidocaine [SEP] sts that transient neurologic symptoms (TNSs) frequently follow lidocaine spinal anesthesia but are infrequent with bupivacaine. However,", "tokenized_content": [2, 19567, 3, 16245, 1988, 6809, 14314, 3601, 12, 7417, 5590, 13, 5467, 2396, 19567, 6071, 8871, 2308, 2032, 21587, 1956, 25473, 18, 2406, 16, 3]}, "items": [{"id": "p_4396", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_4397", "content": "bupivacaine [SEP] ntly follow lidocaine spinal anesthesia but are infrequent with bupivacaine. However, identification of a short-acting local anesthetic to ", "tokenized_content": [2, 25473, 3, 5891, 1954, 2396, 19567, 6071, 8871, 2308, 2032, 21587, 1956, 25473, 18, 2406, 16, 4824, 1927, 43, 3662, 17, 8290, 3076, 16111, 1942, 3]}, "items": [{"id": "p_4397", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_4398", "content": "Prilocaine [SEP] ocaine for brief surgical procedures remains an important goal. Prilocaine is an amide local anesthetic with a duration of action similar ", "tokenized_content": [2, 17618, 6012, 3375, 2053, 3, 5084, 5966, 1958, 5310, 4548, 4869, 4497, 1925, 2715, 6640, 18, 17618, 6012, 3375, 2053, 1977, 1925, 13601, 3076, 16111, 1956, 43, 4392, 1927, 4615, 3]}, "items": [{"id": "p_4398", "content": "Prilocaine [SEP] A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia ", "score": 1, "type": null, "tokenized_content": [2, 17618, 6012, 3375, 2053, 3, 43, 3076, 16111, 1988, 1977, 2551, 24645, 1942, 19567, 18, 5077, 16, 2176, 1977, 2251, 2501, 3868, 1958, 8946, 8871, 3]}]}
{"query": {"id": "q_4399", "content": "prilocaine [SEP] cordingly, the present, prospective double-blind study compares prilocaine with lidocaine and bupivacaine with respect to duration of acti", "tokenized_content": [2, 17618, 6012, 3375, 2053, 3, 6670, 16742, 16, 1920, 2481, 16, 6315, 4825, 17, 7109, 2161, 17012, 17618, 6012, 3375, 2053, 1956, 19567, 1930, 25473, 1956, 5633, 1942, 4392, 1927, 3]}, "items": [{"id": "p_4399", "content": "Prilocaine [SEP] A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia ", "score": 1, "type": null, "tokenized_content": [2, 17618, 6012, 3375, 2053, 3, 43, 3076, 16111, 1988, 1977, 2551, 24645, 1942, 19567, 18, 5077, 16, 2176, 1977, 2251, 2501, 3868, 1958, 8946, 8871, 3]}]}
{"query": {"id": "q_4400", "content": "glucose [SEP]  were randomly allocated to receive 2.5 ml 2% lidocaine in 7.5% glucose, 2% prilocaine in 7.5% glucose, or 0.5% bupivacaine in 7.5% glu", "tokenized_content": [2, 3817, 3, 1985, 6266, 14553, 1942, 7130, 22, 18, 25, 2646, 22, 9, 19567, 1922, 27, 18, 25, 9, 3817, 16, 22, 9, 17618, 6012, 3375, 2053, 1922, 27, 18, 3]}, "items": [{"id": "p_4400", "content": "Glucose [SEP] A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in i", "score": 1, "type": null, "tokenized_content": [2, 3817, 3, 43, 3065, 4585, 1927, 3844, 1958, 5818, 7373, 18, 2176, 1977, 10414, 6966, 1930, 1977, 2435, 1922, 12953, 1930, 2303, 7516, 1927, 4793, 1922, 51, 3]}]}
{"query": {"id": "q_4401", "content": "nicotine [SEP] The role of nicotine in smoking-related cardiovascular disease.", "tokenized_content": [2, 9303, 3, 1920, 2770, 1927, 9303, 1922, 5075, 17, 2712, 5321, 2573, 18, 3]}, "items": [{"id": "p_4401", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_4402", "content": "cardiovascular disease [SEP] The role of nicotine in smoking-related cardiovascular disease.", "tokenized_content": [2, 5321, 2573, 3, 1920, 2770, 1927, 9303, 1922, 5075, 17, 2712, 5321, 2573, 18, 3]}, "items": [{"id": "p_4402", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4403", "content": "Nicotine [SEP] Nicotine activates the sympathetic nervous system and in this way could ", "tokenized_content": [2, 9303, 3, 9303, 9094, 1920, 11739, 7580, 2433, 1930, 1922, 2052, 4222, 2578, 3]}, "items": [{"id": "p_4403", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_4404", "content": "cardiovascular disease [SEP]  sympathetic nervous system and in this way could contribute to cardiovascular disease. Animal studies and mechanistic studies indicate that nicotine ", "tokenized_content": [2, 5321, 2573, 3, 11739, 7580, 2433, 1930, 1922, 2052, 4222, 2578, 4672, 1942, 5321, 2573, 18, 4027, 2351, 1930, 10640, 2351, 3579, 1988, 9303, 3]}, "items": [{"id": "p_4404", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4405", "content": "nicotine [SEP] r disease. Animal studies and mechanistic studies indicate that nicotine could play a role in accelerating atherosclerosis, but evidence", "tokenized_content": [2, 9303, 3, 60, 2573, 18, 4027, 2351, 1930, 10640, 2351, 3579, 1988, 9303, 2578, 3918, 43, 2770, 1922, 21436, 9824, 16, 2308, 3095, 3]}, "items": [{"id": "p_4405", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_4406", "content": "atherosclerosis [SEP] tudies indicate that nicotine could play a role in accelerating atherosclerosis, but evidence among humans is too inadequate to be definitive a", "tokenized_content": [2, 9824, 3, 9037, 7408, 1918, 3579, 1988, 9303, 2578, 3918, 43, 2770, 1922, 21436, 9824, 16, 2308, 3095, 2706, 5209, 1977, 7405, 11391, 1942, 1998, 12072, 43, 3]}, "items": [{"id": "p_4406", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_4407", "content": "carbon monoxide [SEP] he prothrombotic effects of cigarette smoking or the effects of carbon monoxide. Nicotine does not appear to enhance thrombosis among humans. C", "tokenized_content": [2, 5056, 26662, 3, 2234, 2844, 6570, 10123, 3153, 2564, 1927, 10689, 5075, 2014, 1920, 2564, 1927, 5056, 26662, 18, 9303, 3731, 2084, 3267, 1942, 4826, 11354, 2706, 5209, 18, 45, 3]}, "items": [{"id": "p_4407", "content": "Carbon Monoxide [SEP] Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, whi", "score": 1, "type": null, "tokenized_content": [2, 5056, 26662, 3, 5056, 26662, 12, 2081, 13, 18, 43, 15501, 2080, 29500, 16, 12685, 5427, 16, 13891, 5427, 4422, 18, 2176, 17868, 1956, 9652, 1942, 2386, 15750, 20730, 7856, 16, 2003, 1033, 3]}]}
{"query": {"id": "q_4408", "content": "thrombosis [SEP] effects of carbon monoxide. Nicotine does not appear to enhance thrombosis among humans. Clinical studies of pipe smokers and people using", "tokenized_content": [2, 11354, 3, 2564, 1927, 5056, 26662, 18, 9303, 3731, 2084, 3267, 1942, 4826, 11354, 2706, 5209, 18, 2535, 2351, 1927, 6556, 1021, 8112, 1930, 4329, 2193, 3]}, "items": [{"id": "p_4408", "content": "Thrombosis [SEP] Formation and development of a thrombus or blood clot in the blood vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11354, 3, 3337, 1930, 2740, 1927, 43, 16705, 2014, 2877, 15053, 1922, 1920, 2877, 8072, 18, 3]}]}
{"query": {"id": "q_4409", "content": "Seizure [SEP] Seizure resulting from a venlafaxine overdose.", "tokenized_content": [2, 11015, 3, 11015, 3864, 2037, 43, 8102, 5148, 6016, 25204, 21090, 18, 3]}, "items": [{"id": "p_4409", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4410", "content": "venlafaxine [SEP] Seizure resulting from a venlafaxine overdose.", "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 11015, 3864, 2037, 43, 8102, 5148, 6016, 25204, 21090, 18, 3]}, "items": [{"id": "p_4410", "content": "venlafaxine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 3]}]}
{"query": {"id": "q_4411", "content": "overdose [SEP] Seizure resulting from a venlafaxine overdose.", "tokenized_content": [2, 21090, 3, 11015, 3864, 2037, 43, 8102, 5148, 6016, 25204, 21090, 18, 3]}, "items": [{"id": "p_4411", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4412", "content": "venlafaxine [SEP] OBJECTIVE: To report a case of venlafaxine overdose. CASE SUMMARY: A 40-year-old woman with major depressi", "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 8102, 5148, 6016, 25204, 21090, 18, 3087, 6099, 30, 43, 3040, 17, 2476, 17, 4156, 10440, 1956, 3044, 3]}, "items": [{"id": "p_4412", "content": "venlafaxine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8102, 5148, 6016, 25204, 3, 3]}]}
{"query": {"id": "q_4413", "content": "overdose [SEP] OBJECTIVE: To report a case of venlafaxine overdose. CASE SUMMARY: A 40-year-old woman with major depression took a", "tokenized_content": [2, 21090, 3, 4470, 30, 1942, 3809, 43, 3087, 1927, 8102, 5148, 6016, 25204, 21090, 18, 3087, 6099, 30, 43, 3040, 17, 2476, 17, 4156, 10440, 1956, 3044, 4621, 8659, 43, 3]}, "items": [{"id": "p_4413", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4414", "content": "major depression [SEP] of venlafaxine overdose. CASE SUMMARY: A 40-year-old woman with major depression took an overdose of venlafaxine in an apparent suicide attempt.", "tokenized_content": [2, 3044, 4621, 3, 1927, 8102, 5148, 6016, 25204, 21090, 18, 3087, 6099, 30, 43, 3040, 17, 2476, 17, 4156, 10440, 1956, 3044, 4621, 8659, 1925, 21090, 1927, 8102, 5148, 6016, 3]}, "items": [{"id": "p_4414", "content": "Depressive Disorder, Major [SEP] Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.\n  ", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 16, 3044, 3, 4961, 4621, 16905, 1922, 1920, 2755, 2306, 3047, 1930, 4378, 2007, 27013, 16, 2723, 3910, 16, 26124, 26822, 1019, 16, 1930, 18389, 18, 3]}]}
{"query": {"id": "q_4415", "content": "seizure [SEP]  50-mg tablets, the patient experienced a witnessed generalized seizure. She was admitted to the medical intensive care unit, venlafaxi", "tokenized_content": [2, 11015, 3, 2761, 17, 2786, 16576, 16, 1920, 2774, 6090, 43, 27825, 9612, 11015, 18, 4693, 1982, 9723, 1942, 1920, 3423, 8100, 2859, 5344, 16, 8102, 5148, 6016, 18068, 3]}, "items": [{"id": "p_4415", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4416", "content": "nifedipine [SEP] Effect of nifedipine on renal function in liver transplant recipients receiving tacr", "tokenized_content": [2, 25968, 3, 2495, 1927, 25968, 1990, 4604, 2347, 1922, 3568, 5192, 9336, 5962, 9214, 1005, 3]}, "items": [{"id": "p_4416", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_4417", "content": "tacrolimus [SEP] pine on renal function in liver transplant recipients receiving tacrolimus.", "tokenized_content": [2, 21801, 3, 17541, 1990, 4604, 2347, 1922, 3568, 5192, 9336, 5962, 21801, 18, 3]}, "items": [{"id": "p_4417", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4418", "content": "nifedipine [SEP] The effect of nifedipine on renal function in liver transplant recipients who were recei", "tokenized_content": [2, 25968, 3, 1920, 2495, 1927, 25968, 1990, 4604, 2347, 1922, 3568, 5192, 9336, 2746, 1985, 3169, 1033, 3]}, "items": [{"id": "p_4418", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_4419", "content": "tacrolimus [SEP] enal function in liver transplant recipients who were receiving tacrolimus was evaluated between January 1992 and January 1996. Two groups", "tokenized_content": [2, 21801, 3, 2066, 1923, 2347, 1922, 3568, 5192, 9336, 2746, 1985, 5962, 21801, 1982, 3747, 2192, 8555, 8348, 1930, 8555, 6388, 18, 2288, 2671, 3]}, "items": [{"id": "p_4419", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4420", "content": "hypertensive [SEP] mus were compared over a period of 1 year, one group comprising hypertensive patients who were receiving nifedipine, and the other comprisin", "tokenized_content": [2, 11706, 3, 3177, 1985, 2452, 2338, 43, 3047, 1927, 21, 2476, 16, 2340, 2210, 10351, 11706, 2132, 2746, 1985, 5962, 25968, 16, 1930, 1920, 2303, 5663, 1937, 1921, 3]}, "items": [{"id": "p_4420", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4421", "content": "Nifedipine [SEP] e time from transplant to baseline was similar in all patients. Nifedipine significantly improved kidney function as indicated by a signif", "tokenized_content": [2, 25968, 3, 47, 2367, 2037, 5192, 1942, 3703, 1982, 2551, 1922, 2136, 2132, 18, 25968, 2567, 4305, 5245, 2347, 1966, 3391, 2007, 43, 2105, 1974, 3]}, "items": [{"id": "p_4421", "content": "Nifedipine [SEP] A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.\n", "score": 1, "type": null, "tokenized_content": [2, 25968, 3, 43, 6828, 28194, 5899, 1956, 5016, 19052, 4615, 18, 2176, 1977, 43, 4707, 2246, 17, 16961, 1024, 5899, 1988, 2222, 25617, 2877, 3772, 18, 3]}]}
{"query": {"id": "q_4422", "content": "creatinine [SEP] kidney function as indicated by a significant lowering of serum creatinine levels at 6 and 12 months. The observed positive impact of nife", "tokenized_content": [2, 9374, 3, 5245, 2347, 1966, 3391, 2007, 43, 2228, 11187, 1927, 3256, 9374, 2428, 2019, 26, 1930, 2369, 3221, 18, 1920, 2528, 2843, 3829, 1927, 17719, 1021, 3]}, "items": [{"id": "p_4422", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_4423", "content": "nephrotoxicity [SEP] ths. The observed positive impact of nifedipine on reducing the nephrotoxicity associated with tacrolimus in liver transplant recipients shoul", "tokenized_content": [2, 27880, 3, 1913, 1036, 18, 1920, 2528, 2843, 3829, 1927, 25968, 1990, 5526, 1920, 27880, 2458, 1956, 21801, 1922, 3568, 5192, 9336, 8406, 1944, 3]}, "items": [{"id": "p_4423", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4424", "content": "hypertension [SEP] ts should be an important factor in selecting an agent to treat hypertension in this population.", "tokenized_content": [2, 5579, 3, 4894, 3066, 1998, 1925, 2715, 2991, 1922, 12475, 1925, 5899, 1942, 2297, 5579, 1922, 2052, 2973, 18, 3]}, "items": [{"id": "p_4424", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4425", "content": "Sinus arrest [SEP] Sinus arrest associated with continuous-infusion cimetidine.", "tokenized_content": [2, 9414, 8048, 3, 9414, 8048, 2458, 1956, 4798, 17, 7386, 20090, 4988, 27099, 18, 3]}, "items": [{"id": "p_4425", "content": "Sinus Arrest, Cardiac [SEP] The omission of atrial activation that is caused by transient cessation of impulse generation at the SINOATRIAL NODE. It is char", "score": 1, "type": null, "tokenized_content": [2, 9414, 8048, 16, 4435, 3, 1920, 25779, 1927, 9224, 2936, 1988, 1977, 4189, 2007, 6809, 10975, 1927, 21896, 4841, 2019, 1920, 3132, 6952, 17075, 6267, 18, 2176, 1977, 2618, 3]}]}
{"query": {"id": "q_4426", "content": "cimetidine [SEP] Sinus arrest associated with continuous-infusion cimetidine.", "tokenized_content": [2, 20090, 4988, 27099, 3, 9414, 8048, 2458, 1956, 4798, 17, 7386, 20090, 4988, 27099, 18, 3]}, "items": [{"id": "p_4426", "content": "Cimetidine [SEP] A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacol", "score": 1, "type": null, "tokenized_content": [2, 20090, 4988, 27099, 3, 43, 14622, 8680, 1915, 16, 2176, 10362, 1954, 7042, 14622, 2743, 1942, 14622, 4881, 4086, 18, 20090, 4988, 27099, 2258, 43, 3109, 1927, 22543, 3]}]}
{"query": {"id": "q_4427", "content": "cimetidine [SEP] The administration of intermittent intravenous infusions of cimetidine is infrequently associated with the development of bradyarrhyth", "tokenized_content": [2, 20090, 4988, 27099, 3, 1920, 4183, 1927, 13252, 7307, 17656, 1927, 20090, 4988, 27099, 1977, 28177, 2458, 1956, 1920, 2740, 1927, 20152, 23246, 3]}, "items": [{"id": "p_4427", "content": "Cimetidine [SEP] A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacol", "score": 1, "type": null, "tokenized_content": [2, 20090, 4988, 27099, 3, 43, 14622, 8680, 1915, 16, 2176, 10362, 1954, 7042, 14622, 2743, 1942, 14622, 4881, 4086, 18, 20090, 4988, 27099, 2258, 43, 3109, 1927, 22543, 3]}]}
{"query": {"id": "q_4428", "content": "bradyarrhythmias [SEP] f cimetidine is infrequently associated with the development of bradyarrhythmias. A 40-year-old man with leukemia and no history of cardiac dise", "tokenized_content": [2, 20152, 23246, 15519, 3, 48, 20090, 4988, 27099, 1977, 28177, 2458, 1956, 1920, 2740, 1927, 20152, 23246, 15519, 18, 43, 3040, 17, 2476, 17, 4156, 2323, 1956, 8111, 1930, 2239, 3]}, "items": [{"id": "p_4428", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_4429", "content": "leukemia [SEP] ith the development of bradyarrhythmias. A 40-year-old man with leukemia and no history of cardiac disease developed recurrent, brief ep", "tokenized_content": [2, 8111, 3, 24737, 1920, 2740, 1927, 20152, 23246, 15519, 18, 43, 3040, 17, 2476, 17, 4156, 2323, 1956, 8111, 1930, 2239, 4403, 1927, 4435, 2573, 3530, 7457, 16, 5310, 2630, 3]}, "items": [{"id": "p_4429", "content": "Leukemia [SEP] A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukoc", "score": 1, "type": null, "tokenized_content": [2, 8111, 3, 43, 7529, 16, 6558, 2573, 1927, 1920, 2877, 17, 7402, 7393, 16, 4378, 2007, 22797, 4031, 1930, 2740, 1927, 5104, 1994, 3]}]}
{"query": {"id": "q_4430", "content": "cardiac disease [SEP] yarrhythmias. A 40-year-old man with leukemia and no history of cardiac disease developed recurrent, brief episodes of apparent sinus arrest wh", "tokenized_content": [2, 4435, 2573, 3, 26169, 18858, 10245, 15519, 18, 43, 3040, 17, 2476, 17, 4156, 2323, 1956, 8111, 1930, 2239, 4403, 1927, 4435, 2573, 3530, 7457, 16, 5310, 9232, 1927, 6273, 3]}, "items": [{"id": "p_4430", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_4431", "content": "sinus arrest [SEP] cardiac disease developed recurrent, brief episodes of apparent sinus arrest while receiving continuous-infusion cimetidine 50 mg/hour. The ", "tokenized_content": [2, 9414, 8048, 3, 4435, 2573, 3530, 7457, 16, 5310, 9232, 1927, 6273, 9414, 8048, 2679, 5962, 4798, 17, 7386, 20090, 4988, 27099, 2761, 2786, 19, 6231, 18, 1920, 3]}, "items": [{"id": "p_4431", "content": "Sinus Arrest, Cardiac [SEP] The omission of atrial activation that is caused by transient cessation of impulse generation at the SINOATRIAL NODE. It is char", "score": 1, "type": null, "tokenized_content": [2, 9414, 8048, 16, 4435, 3, 1920, 25779, 1927, 9224, 2936, 1988, 1977, 4189, 2007, 6809, 10975, 1927, 21896, 4841, 2019, 1920, 3132, 6952, 17075, 6267, 18, 2176, 1977, 2618, 3]}]}
{"query": {"id": "q_4432", "content": "arrhythmias [SEP] etidine is infrequently associated with the development of bradyarrhythmias. A 40-year-old man with leukemia and no history of cardiac dise", "tokenized_content": [2, 16934, 3, 8096, 27099, 1977, 28177, 2458, 1956, 1920, 2740, 1927, 20152, 23246, 15519, 18, 43, 3040, 17, 2476, 17, 4156, 2323, 1956, 8111, 1930, 2239, 4403, 1927, 4435, 2445, 3]}, "items": [{"id": "p_4432", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_4433", "content": "ranitidine [SEP] ration, disappeared after dechallenge, and did not recur during ranitidine treatment. This is the first reported case of sinus arrest asso", "tokenized_content": [2, 2845, 2078, 27099, 3, 12488, 16, 15588, 2256, 2344, 7289, 15253, 2106, 16, 1930, 2811, 2084, 2090, 1949, 2409, 2845, 2078, 27099, 2311, 18, 2052, 1977, 1920, 2561, 2568, 3087, 3]}, "items": [{"id": "p_4433", "content": "Ranitidine [SEP] A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastroin", "score": 1, "type": null, "tokenized_content": [2, 2845, 2078, 27099, 3, 43, 2447, 17, 16045, 14580, 1927, 2690, 14622, 4086, 1988, 8265, 6319, 5512, 12, 4881, 4086, 13, 18, 2176, 1977, 2251, 1942, 2297, 6858, 1921, 3]}]}
{"query": {"id": "q_4434", "content": "gall bladder stones [SEP] Composition of gall bladder stones associated with octreotide: response to oral ursodeoxycholic ac", "tokenized_content": [2, 9354, 7821, 18183, 3, 5128, 1927, 9354, 7821, 18183, 2458, 1956, 5843, 29351, 30, 2644, 1942, 4726, 29321, 21554, 3204, 4485, 2000, 3]}, "items": [{"id": "p_4434", "content": "Gallstones [SEP] Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHI", "score": 1, "type": null, "tokenized_content": [2, 9354, 22727, 1036, 3, 5358, 14631, 25339, 1922, 1920, 13210, 6482, 16, 5394, 5333, 1922, 1920, 19358, 16, 3864, 1922, 1920, 2625, 1927, 6268, 11085, 22523, 3]}]}
{"query": {"id": "q_4435", "content": "octreotide [SEP] Composition of gall bladder stones associated with octreotide: response to oral ursodeoxycholic acid.", "tokenized_content": [2, 5843, 29351, 3, 5128, 1927, 9354, 7821, 18183, 2458, 1956, 5843, 29351, 30, 2644, 1942, 4726, 29321, 21554, 3204, 4485, 2687, 18, 3]}, "items": [{"id": "p_4435", "content": "Octreotide [SEP] A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat h", "score": 1, "type": null, "tokenized_content": [2, 5843, 29351, 3, 43, 6828, 16, 2815, 17, 8290, 6830, 20698, 5843, 24010, 5729, 1988, 7042, 5512, 1927, 2905, 6365, 1930, 1977, 2251, 1942, 2297, 50, 3]}]}
{"query": {"id": "q_4436", "content": "ursodeoxycholic acid [SEP] all bladder stones associated with octreotide: response to oral ursodeoxycholic acid.", "tokenized_content": [2, 29321, 21554, 3204, 4485, 2687, 3, 2136, 7821, 18183, 2458, 1956, 5843, 29351, 30, 2644, 1942, 4726, 29321, 21554, 3204, 4485, 2687, 18, 3]}, "items": [{"id": "p_4436", "content": "Ursodeoxycholic Acid [SEP] An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or ", "score": 1, "type": null, "tokenized_content": [2, 29321, 21554, 3204, 4485, 2687, 3, 1925, 13872, 9213, 1927, 10280, 21554, 3204, 4485, 2687, 18, 2176, 1977, 43, 6492, 9619, 2687, 2435, 2561, 1922, 1920, 16969, 1930, 1977, 10535, 3108, 43, 7897, 2014, 3]}]}
{"query": {"id": "q_4437", "content": "Octreotide [SEP] Octreotide, an effective treatment for acromegaly, induces gall bladder st", "tokenized_content": [2, 5843, 29351, 3, 5843, 29351, 16, 1925, 3655, 2311, 1958, 10428, 19323, 16, 6387, 9354, 7821, 1955, 3]}, "items": [{"id": "p_4437", "content": "Octreotide [SEP] A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat h", "score": 1, "type": null, "tokenized_content": [2, 5843, 29351, 3, 43, 6828, 16, 2815, 17, 8290, 6830, 20698, 5843, 24010, 5729, 1988, 7042, 5512, 1927, 2905, 6365, 1930, 1977, 2251, 1942, 2297, 50, 3]}]}
{"query": {"id": "q_4438", "content": "acromegaly [SEP] Octreotide, an effective treatment for acromegaly, induces gall bladder stones in 13-60% of patients. Because kno", "tokenized_content": [2, 10428, 19323, 3, 5843, 29351, 16, 1925, 3655, 2311, 1958, 10428, 19323, 16, 6387, 9354, 7821, 18183, 1922, 2590, 17, 3276, 9, 1927, 2132, 18, 2882, 2547, 1037, 3]}, "items": [{"id": "p_4438", "content": "Acromegaly [SEP] A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of", "score": 1, "type": null, "tokenized_content": [2, 10428, 19323, 3, 43, 2625, 4189, 2007, 7171, 3395, 1942, 9122, 2616, 2905, 6365, 1922, 4440, 18, 2176, 1977, 4378, 2007, 18525, 16363, 1927, 3]}]}
{"query": {"id": "q_4439", "content": "gall bladder stones [SEP] Octreotide, an effective treatment for acromegaly, induces gall bladder stones in 13-60% of patients. Because knowledge of stone composition i", "tokenized_content": [2, 9354, 7821, 18183, 3, 5843, 29351, 16, 1925, 3655, 2311, 1958, 10428, 19323, 16, 6387, 9354, 7821, 18183, 1922, 2590, 17, 3276, 9, 1927, 2132, 18, 2882, 4163, 1927, 14595, 3]}, "items": [{"id": "p_4439", "content": "Gallstones [SEP] Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHI", "score": 1, "type": null, "tokenized_content": [2, 9354, 22727, 1036, 3, 5358, 14631, 25339, 1922, 1920, 13210, 6482, 16, 5394, 5333, 1922, 1920, 19358, 16, 3864, 1922, 1920, 2625, 1927, 6268, 11085, 22523, 3]}]}
{"query": {"id": "q_4440", "content": "octreotide [SEP] ion, this was investigated by direct and indirect methods in 14 octreotide treated acromegalic patients with gall stones. Chemical analysi", "tokenized_content": [2, 5843, 29351, 3, 4755, 16, 2052, 1982, 3845, 2007, 3083, 1930, 6354, 2860, 1922, 2607, 5843, 29351, 2868, 10428, 14259, 1935, 2132, 1956, 9354, 18183, 18, 4399, 2241, 1033, 3]}, "items": [{"id": "p_4440", "content": "Octreotide [SEP] A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat h", "score": 1, "type": null, "tokenized_content": [2, 5843, 29351, 3, 43, 6828, 16, 2815, 17, 8290, 6830, 20698, 5843, 24010, 5729, 1988, 7042, 5512, 1927, 2905, 6365, 1930, 1977, 2251, 1942, 2297, 50, 3]}]}
{"query": {"id": "q_4441", "content": "acromegalic [SEP] tigated by direct and indirect methods in 14 octreotide treated acromegalic patients with gall stones. Chemical analysis of gall stones ret", "tokenized_content": [2, 10428, 14259, 1935, 3, 23013, 1981, 2007, 3083, 1930, 6354, 2860, 1922, 2607, 5843, 29351, 2868, 10428, 14259, 1935, 2132, 1956, 9354, 18183, 18, 4399, 2333, 1927, 9354, 18183, 3172, 3]}, "items": [{"id": "p_4441", "content": "Acromegaly [SEP] A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of", "score": 1, "type": null, "tokenized_content": [2, 10428, 19323, 3, 43, 2625, 4189, 2007, 7171, 3395, 1942, 9122, 2616, 2905, 6365, 1922, 4440, 18, 2176, 1977, 4378, 2007, 18525, 16363, 1927, 3]}]}
{"query": {"id": "q_4442", "content": "gall stones [SEP] rect methods in 14 octreotide treated acromegalic patients with gall stones. Chemical analysis of gall stones retrieved at cholecystectomy ", "tokenized_content": [2, 9354, 18183, 3, 10560, 2860, 1922, 2607, 5843, 29351, 2868, 10428, 14259, 1935, 2132, 1956, 9354, 18183, 18, 4399, 2333, 1927, 9354, 18183, 10931, 2019, 23661, 3]}, "items": [{"id": "p_4442", "content": "Gallstones [SEP] Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHI", "score": 1, "type": null, "tokenized_content": [2, 9354, 22727, 1036, 3, 5358, 14631, 25339, 1922, 1920, 13210, 6482, 16, 5394, 5333, 1922, 1920, 19358, 16, 3864, 1922, 1920, 2625, 1927, 6268, 11085, 22523, 3]}]}
{"query": {"id": "q_4443", "content": "cholesterol [SEP] ctomy from two patients, showed that they contained 71% and 87% cholesterol by weight. In the remaining 12 patients, localised computed tom", "tokenized_content": [2, 5463, 3, 3369, 3542, 2037, 2288, 2132, 16, 2594, 1988, 2611, 5543, 5858, 9, 1930, 5783, 9, 5463, 2007, 3388, 18, 1922, 1920, 5719, 2369, 2132, 16, 25664, 6287, 5970, 3]}, "items": [{"id": "p_4443", "content": "Cholesterol [SEP] The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fat", "score": 1, "type": null, "tokenized_content": [2, 5463, 3, 1920, 7944, 20408, 1927, 2136, 2580, 3555, 16, 6533, 1922, 3362, 3878, 16, 4369, 1920, 3068, 1930, 6071, 6670, 16, 1930, 1922, 4027, 3777, 3]}]}
{"query": {"id": "q_4444", "content": "ursodeoxycholic acid [SEP] ediately after sampling. Of the 12 patients considered for oral ursodeoxycholic acid (UDCA) treatment, two had a blocked cystic duct and were not st", "tokenized_content": [2, 29321, 21554, 3204, 4485, 2687, 3, 3347, 13239, 2256, 5603, 18, 1927, 1920, 2369, 2132, 3311, 1958, 4726, 29321, 21554, 3204, 4485, 2687, 12, 19803, 3375, 13, 2311, 16, 2288, 3]}, "items": [{"id": "p_4444", "content": "Ursodeoxycholic Acid [SEP] An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or ", "score": 1, "type": null, "tokenized_content": [2, 29321, 21554, 3204, 4485, 2687, 3, 1925, 13872, 9213, 1927, 10280, 21554, 3204, 4485, 2687, 18, 2176, 1977, 43, 6492, 9619, 2687, 2435, 2561, 1922, 1920, 16969, 1930, 1977, 10535, 3108, 43, 7897, 2014, 3]}]}
{"query": {"id": "q_4445", "content": "UDCA [SEP] g. Of the 12 patients considered for oral ursodeoxycholic acid (UDCA) treatment, two had a blocked cystic duct and were not started ", "tokenized_content": [2, 19803, 3375, 3, 49, 18, 1927, 1920, 2369, 2132, 3311, 1958, 4726, 29321, 21554, 3204, 4485, 2687, 12, 19803, 3375, 13, 2311, 16, 2288, 2430, 43, 6923, 11656, 10840, 1930, 3]}, "items": [{"id": "p_4445", "content": "Ursodeoxycholic Acid [SEP] An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or ", "score": 1, "type": null, "tokenized_content": [2, 29321, 21554, 3204, 4485, 2687, 3, 1925, 13872, 9213, 1927, 10280, 21554, 3204, 4485, 2687, 18, 2176, 1977, 43, 6492, 9619, 2687, 2435, 2561, 1922, 1920, 16969, 1930, 1977, 10535, 3108, 43, 7897, 2014, 3]}]}
{"query": {"id": "q_4446", "content": "gall stone [SEP] rect methods in 14 octreotide treated acromegalic patients with gall stones. Chemical analysis of gall stones retrieved at cholecystectomy", "tokenized_content": [2, 9354, 14595, 3, 10560, 2860, 1922, 2607, 5843, 29351, 2868, 10428, 14259, 1935, 2132, 1956, 9354, 18183, 18, 4399, 2333, 1927, 9354, 18183, 10931, 2019, 23661, 3]}, "items": [{"id": "p_4446", "content": "Gallstones [SEP] Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHI", "score": 1, "type": null, "tokenized_content": [2, 9354, 22727, 1036, 3, 5358, 14631, 25339, 1922, 1920, 13210, 6482, 16, 5394, 5333, 1922, 1920, 19358, 16, 3864, 1922, 1920, 2625, 1927, 6268, 11085, 22523, 3]}]}
{"query": {"id": "q_4447", "content": "gall stone disease [SEP] iple, and cholesterol rich although, in common with spontaneous gall stone disease, at presentation some patients will have a blocked cystic duct ", "tokenized_content": [2, 9354, 14595, 2573, 3, 21844, 1021, 16, 1930, 5463, 5536, 2876, 16, 1922, 3059, 1956, 6242, 9354, 14595, 2573, 16, 2019, 6544, 2673, 2132, 2832, 2162, 43, 6923, 11656, 10840, 3]}, "items": [{"id": "p_4447", "content": "Gallstones [SEP] Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHI", "score": 1, "type": null, "tokenized_content": [2, 9354, 22727, 1036, 3, 5358, 14631, 25339, 1922, 1920, 13210, 6482, 16, 5394, 5333, 1922, 1920, 19358, 16, 3864, 1922, 1920, 2625, 1927, 6268, 11085, 22523, 3]}]}
{"query": {"id": "q_4448", "content": "calcium [SEP] will have a blocked cystic duct and some gall stones containing calcium.", "tokenized_content": [2, 5016, 3, 2832, 2162, 43, 6923, 11656, 10840, 1930, 2673, 9354, 18183, 3165, 5016, 18, 3]}, "items": [{"id": "p_4448", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_4449", "content": "Cardiovascular complications [SEP] Cardiovascular complications associated with terbutaline treatment for preterm labor.", "tokenized_content": [2, 5321, 5021, 3, 5321, 5021, 2458, 1956, 6005, 16119, 8177, 2311, 1958, 10435, 3876, 18, 3]}, "items": [{"id": "p_4449", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4450", "content": "terbutaline [SEP] Cardiovascular complications associated with terbutaline treatment for preterm labor.", "tokenized_content": [2, 6005, 16119, 8177, 3, 5321, 5021, 2458, 1956, 6005, 16119, 8177, 2311, 1958, 10435, 3876, 18, 3]}, "items": [{"id": "p_4450", "content": "Terbutaline [SEP] A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6005, 16119, 8177, 3, 43, 5328, 4666, 17, 22, 13672, 7829, 2251, 1966, 43, 26272, 3061, 1930, 21682, 6586, 18, 3]}]}
{"query": {"id": "q_4451", "content": "preterm labor [SEP] ascular complications associated with terbutaline treatment for preterm labor.", "tokenized_content": [2, 10435, 3876, 3, 7249, 2168, 5021, 2458, 1956, 6005, 16119, 8177, 2311, 1958, 10435, 3876, 18, 3]}, "items": [{"id": "p_4451", "content": "Obstetric Labor, Premature [SEP] Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime d", "score": 1, "type": null, "tokenized_content": [2, 18902, 3876, 16, 9839, 3, 4727, 1927, 18902, 3876, 3119, 2576, 12, 2576, 5043, 13, 2308, 5394, 2256, 1920, 15722, 2258, 5433, 8978, 18, 1922, 5209, 16, 2176, 5110, 2673, 6995, 46, 3]}]}
{"query": {"id": "q_4452", "content": "cardiovascular complications [SEP] Severe cardiovascular complications occurred in eight of 160 patients treated with terbutaline for ", "tokenized_content": [2, 5321, 5021, 3, 4010, 5321, 5021, 4807, 1922, 5066, 1927, 9608, 2132, 2868, 1956, 6005, 16119, 8177, 1958, 3]}, "items": [{"id": "p_4452", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4453", "content": "terbutaline [SEP] ar complications occurred in eight of 160 patients treated with terbutaline for preterm labor. Associated corticosteroid therapy and twin g", "tokenized_content": [2, 6005, 16119, 8177, 3, 2245, 5021, 4807, 1922, 5066, 1927, 9608, 2132, 2868, 1956, 6005, 16119, 8177, 1958, 10435, 3876, 18, 2458, 17980, 3181, 1930, 13392, 49, 3]}, "items": [{"id": "p_4453", "content": "Terbutaline [SEP] A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.\n    ", "score": 1, "type": null, "tokenized_content": [2, 6005, 16119, 8177, 3, 43, 5328, 4666, 17, 22, 13672, 7829, 2251, 1966, 43, 26272, 3061, 1930, 21682, 6586, 18, 3]}]}
{"query": {"id": "q_4454", "content": "preterm labor [SEP]  occurred in eight of 160 patients treated with terbutaline for preterm labor. Associated corticosteroid therapy and twin gestations appear t", "tokenized_content": [2, 10435, 3876, 3, 4807, 1922, 5066, 1927, 9608, 2132, 2868, 1956, 6005, 16119, 8177, 1958, 10435, 3876, 18, 2458, 17980, 3181, 1930, 13392, 10879, 1036, 3267, 62, 3]}, "items": [{"id": "p_4454", "content": "Obstetric Labor, Premature [SEP] Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime d", "score": 1, "type": null, "tokenized_content": [2, 18902, 3876, 16, 9839, 3, 4727, 1927, 18902, 3876, 3119, 2576, 12, 2576, 5043, 13, 2308, 5394, 2256, 1920, 15722, 2258, 5433, 8978, 18, 1922, 5209, 16, 2176, 5110, 2673, 6995, 46, 3]}]}
{"query": {"id": "q_4455", "content": "2-chloroprocaine-CE [SEP] Neurologic effects of subarachnoid administration of 2-chloroprocaine-CE, bupivacaine, and low pH normal saline in dogs.", "tokenized_content": [2, 22, 17, 10107, 2216, 3375, 2053, 17, 5827, 3, 14314, 2564, 1927, 23795, 4183, 1927, 22, 17, 10107, 2216, 3375, 2053, 17, 5827, 16, 25473, 16, 1930, 2330, 2087, 2791, 3]}, "items": [{"id": "p_4455", "content": "chloroprocaine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10107, 2216, 3375, 2053, 3, 3]}]}
{"query": {"id": "q_4456", "content": "bupivacaine [SEP]  effects of subarachnoid administration of 2-chloroprocaine-CE, bupivacaine, and low pH normal saline in dogs.", "tokenized_content": [2, 25473, 3, 2564, 1927, 23795, 4183, 1927, 22, 17, 10107, 2216, 3375, 2053, 17, 5827, 16, 25473, 16, 1930, 2330, 2087, 2791, 5977, 1922, 7894, 18, 3]}, "items": [{"id": "p_4456", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_4457", "content": "2-chloroprocaine-CE [SEP] uences of deliberate subarachnoid injection of large volumes of 2-chloroprocaine-CE in experimental animals. The possible role of low pH as well as", "tokenized_content": [2, 22, 17, 10107, 2216, 3375, 2053, 17, 5827, 3, 63, 2408, 1927, 24921, 13108, 23795, 4107, 1927, 3103, 8101, 1927, 22, 17, 10107, 2216, 3375, 2053, 17, 5827, 1922, 3599, 3]}, "items": [{"id": "p_4457", "content": "chloroprocaine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10107, 2216, 3375, 2053, 3, 3]}]}
{"query": {"id": "q_4458", "content": "neurotoxicity [SEP]  low pH as well as total volume as potential factors in causing neurotoxicity was evaluated. The 65 dogs in the study received injections in ", "tokenized_content": [2, 18034, 3, 2330, 2087, 1966, 2486, 1966, 2698, 3776, 1966, 2889, 2790, 1922, 7538, 18034, 1982, 3747, 18, 1920, 4459, 7894, 1922, 1920, 2161, 4004, 8775, 1922, 3]}, "items": [{"id": "p_4458", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4459", "content": "bupivacaine [SEP] d injections in the subarachnoid space as follows: 6 to 8 ml of bupivacaine (N = 15), 2-chloroprocaine-CE (N = 20), low pH normal saline (p", "tokenized_content": [2, 25473, 3, 46, 8775, 1922, 1920, 23795, 5230, 1966, 6052, 30, 26, 1942, 28, 2646, 1927, 25473, 12, 56, 33, 2461, 13, 16, 22, 17, 10107, 2216, 3375, 2053, 17, 3]}, "items": [{"id": "p_4459", "content": "Bupivacaine [SEP] A widely used local anesthetic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25473, 3, 43, 5673, 2251, 3076, 16111, 5899, 18, 3]}]}
{"query": {"id": "q_4460", "content": "paralysis [SEP] njection of 2-chloroprocaine-CE seven (35%) developed hind-limb paralysis. None of the animals that received bupivacaine, normal saline, ", "tokenized_content": [2, 18973, 3, 11421, 2198, 1927, 22, 17, 10107, 2216, 3375, 2053, 17, 5827, 5260, 12, 3259, 9, 13, 3530, 8858, 17, 7755, 18973, 18, 6046, 1927, 1920, 3555, 1988, 4004, 3]}, "items": [{"id": "p_4460", "content": "Paralysis [SEP] A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level", "score": 1, "type": null, "tokenized_content": [2, 18973, 3, 43, 3335, 2576, 2501, 3868, 2251, 1942, 5993, 4010, 2014, 4080, 3257, 1927, 3760, 4568, 2810, 1942, 4842, 2433, 2573, 2037, 1920, 2237, 3]}]}
{"query": {"id": "q_4461", "content": "subpial necrosis [SEP] rds of the animals that received 2-chloroprocaine-CE, 13 showed subpial necrosis; the nerve roots and subarachnoid vessels were normal. The spin", "tokenized_content": [2, 10385, 2086, 7476, 3, 25503, 1927, 1920, 3555, 1988, 4004, 22, 17, 10107, 2216, 3375, 2053, 17, 5827, 16, 2590, 2594, 10385, 2086, 7476, 31, 1920, 5507, 9398, 1930, 23795, 3]}, "items": [{"id": "p_4461", "content": "Spinal Cord Diseases [SEP] Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimening", "score": 1, "type": null, "tokenized_content": [2, 6071, 6670, 3902, 3, 11896, 2961, 2154, 5961, 6071, 6670, 4293, 2014, 5273, 16, 2710, 4414, 5884, 1920, 10286, 1918, 1930, 2953, 19047, 1941, 3]}]}
{"query": {"id": "q_4462", "content": "adriamycin [SEP] Early adjuvant adriamycin in superficial bladder carcinoma.", "tokenized_content": [2, 25622, 7898, 3, 3120, 8968, 25622, 7898, 1922, 12176, 7821, 5373, 18, 3]}, "items": [{"id": "p_4462", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4463", "content": "bladder carcinoma [SEP] Early adjuvant adriamycin in superficial bladder carcinoma.", "tokenized_content": [2, 7821, 5373, 3, 3120, 8968, 25622, 7898, 1922, 12176, 7821, 5373, 18, 3]}, "items": [{"id": "p_4463", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_4464", "content": "carcinoma [SEP] Early adjuvant adriamycin in superficial bladder carcinoma.", "tokenized_content": [2, 5373, 3, 3120, 8968, 25622, 7898, 1922, 12176, 7821, 5373, 18, 3]}, "items": [{"id": "p_4464", "content": "Carcinoma [SEP] A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It i", "score": 1, "type": null, "tokenized_content": [2, 5373, 3, 43, 6558, 12132, 3915, 2353, 1927, 4944, 2094, 5370, 1941, 1942, 19155, 1920, 7510, 3878, 1930, 7031, 7164, 1942, 8174, 18, 2176, 51, 3]}]}
{"query": {"id": "q_4465", "content": "carcinoma of the bladder [SEP] as performed in 110 patients with superficial transitional cell carcinoma of the bladder. Adriamycin (50 mg/50 ml) was administered intravesically withi", "tokenized_content": [2, 5373, 1927, 1920, 7821, 3, 1966, 2593, 1922, 8139, 2132, 1956, 12176, 20086, 2024, 5373, 1927, 1920, 7821, 18, 25622, 7898, 12, 2761, 2786, 19, 2761, 2646, 13, 1982, 5254, 3]}, "items": [{"id": "p_4465", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_4466", "content": "carcinoma [SEP] as performed in 110 patients with superficial transitional cell carcinoma of the bladder. Adriamycin (50 mg/50 ml) was administered intra", "tokenized_content": [2, 5373, 3, 1966, 2593, 1922, 8139, 2132, 1956, 12176, 20086, 2024, 5373, 1927, 1920, 7821, 18, 25622, 7898, 12, 2761, 2786, 19, 2761, 2646, 13, 1982, 5254, 5153, 3]}, "items": [{"id": "p_4466", "content": "Carcinoma [SEP] A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It i", "score": 1, "type": null, "tokenized_content": [2, 5373, 3, 43, 6558, 12132, 3915, 2353, 1927, 4944, 2094, 5370, 1941, 1942, 19155, 1920, 7510, 3878, 1930, 7031, 7164, 1942, 8174, 18, 2176, 51, 3]}]}
{"query": {"id": "q_4467", "content": "Adriamycin [SEP] ts with superficial transitional cell carcinoma of the bladder. Adriamycin (50 mg/50 ml) was administered intravesically within 24 h after", "tokenized_content": [2, 25622, 7898, 3, 4894, 1956, 12176, 20086, 2024, 5373, 1927, 1920, 7821, 18, 25622, 7898, 12, 2761, 2786, 19, 2761, 2646, 13, 1982, 5254, 6306, 18522, 5657, 1954, 2651, 2686, 3]}, "items": [{"id": "p_4467", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4468", "content": "bladder tumors [SEP] ically within 24 h after transurethral resection of TA-T1 (O-A) bladder tumors. Instillation was repeated twice during the first week, then we", "tokenized_content": [2, 7821, 3861, 3, 14784, 11560, 1012, 2651, 2686, 50, 2256, 2127, 30494, 7317, 6953, 1927, 4410, 17, 6197, 12, 57, 17, 43, 13, 7821, 3861, 18, 24893, 1982, 5116, 6470, 3]}, "items": [{"id": "p_4468", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_4469", "content": "cystitis [SEP] ented with local side-effects. In 24 of these patients chemical cystitis was severe enough for them to drop out of the study. No systemi", "tokenized_content": [2, 9446, 3678, 3, 8496, 1919, 1956, 3076, 4159, 17, 2564, 18, 1922, 2686, 1927, 2144, 2132, 4399, 9446, 3678, 1982, 4010, 7867, 1958, 3581, 1942, 7086, 2397, 1927, 1920, 2161, 3]}, "items": [{"id": "p_4469", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_4470", "content": "tumors [SEP] ithin 24 h after transurethral resection of TA-T1 (O-A) bladder tumors. Instillation was repeated twice during the first week, then we", "tokenized_content": [2, 3861, 3, 24737, 1921, 2686, 50, 2256, 2127, 30494, 7317, 6953, 1927, 4410, 17, 6197, 12, 57, 17, 43, 13, 7821, 3861, 18, 24893, 1982, 5116, 6470, 2409, 1920, 2561, 3]}, "items": [{"id": "p_4470", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4471", "content": "tumor [SEP] ithin 24 h after transurethral resection of TA-T1 (O-A) bladder tumors. Instillation was repeated twice during the first week, then w", "tokenized_content": [2, 2798, 3, 24737, 1921, 2686, 50, 2256, 2127, 30494, 7317, 6953, 1927, 4410, 17, 6197, 12, 57, 17, 43, 13, 7821, 3861, 18, 24893, 1982, 5116, 6470, 2409, 1920, 2561, 3]}, "items": [{"id": "p_4471", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4472", "content": "Hyperkalemia [SEP] Hyperkalemia associated with sulindac therapy.", "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 4194, 7640, 1952, 6026, 2458, 1956, 9596, 2762, 1948, 3181, 18, 3]}, "items": [{"id": "p_4472", "content": "Hyperkalemia [SEP] Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinicall", "score": 1, "type": null, "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 20756, 2149, 9057, 3110, 1922, 1920, 2877, 16, 2501, 3868, 2810, 1942, 9785, 4604, 11093, 18, 2176, 1977, 4378, 2535, 1024, 3]}]}
{"query": {"id": "q_4473", "content": "sulindac [SEP] Hyperkalemia associated with sulindac therapy.", "tokenized_content": [2, 9596, 2762, 1948, 3, 4194, 7640, 1952, 6026, 2458, 1956, 9596, 2762, 1948, 3181, 18, 3]}, "items": [{"id": "p_4473", "content": "Sulindac [SEP] A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the p", "score": 1, "type": null, "tokenized_content": [2, 9596, 2762, 1948, 3, 43, 5141, 1921, 2199, 2762, 2880, 10533, 21499, 6098, 5141, 1921, 2199, 11804, 1977, 9076, 1922, 3597, 1942, 1925, 3500, 24194, 14501, 18, 4475, 16, 1920, 58, 3]}]}
{"query": {"id": "q_4474", "content": "Hyperkalemia [SEP] Hyperkalemia has recently been recognized as a complication of nonsteroidal ", "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 4194, 7640, 1952, 6026, 2258, 3998, 2252, 6783, 1966, 43, 9388, 1927, 29413, 3]}, "items": [{"id": "p_4474", "content": "Hyperkalemia [SEP] Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinicall", "score": 1, "type": null, "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 20756, 2149, 9057, 3110, 1922, 1920, 2877, 16, 2501, 3868, 2810, 1942, 9785, 4604, 11093, 18, 2176, 1977, 4378, 2535, 1024, 3]}]}
{"query": {"id": "q_4475", "content": "indomethacin [SEP] ication of nonsteroidal antiinflammatory agents (NSAID) such as indomethacin. Several recent studies have stressed the renal sparing feature", "tokenized_content": [2, 20463, 3, 14784, 1929, 1927, 29413, 2246, 9899, 4820, 12, 24194, 13, 2427, 1966, 20463, 18, 2980, 3505, 2351, 2162, 14438, 1920, 4604, 17981, 5961, 3]}, "items": [{"id": "p_4475", "content": "Indomethacin [SEP] A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostagla", "score": 1, "type": null, "tokenized_content": [2, 20463, 3, 43, 2447, 17, 24932, 2246, 17, 3769, 5899, 12, 24194, 13, 1988, 7042, 1920, 4113, 21271, 4680, 1958, 1920, 3337, 1927, 4876, 15915, 1019, 3]}]}
{"query": {"id": "q_4476", "content": "sulindac [SEP] eral recent studies have stressed the renal sparing features of sulindac, owing to its lack of interference with renal prostacyclin synt", "tokenized_content": [2, 9596, 2762, 1948, 3, 14821, 1024, 3505, 2351, 2162, 14438, 1920, 4604, 17981, 4075, 1927, 9596, 2762, 1948, 16, 10762, 1942, 2496, 3630, 1927, 8703, 1956, 4604, 4876, 23689, 1921, 3]}, "items": [{"id": "p_4476", "content": "Sulindac [SEP] A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the p", "score": 1, "type": null, "tokenized_content": [2, 9596, 2762, 1948, 3, 43, 5141, 1921, 2199, 2762, 2880, 10533, 21499, 6098, 5141, 1921, 2199, 11804, 1977, 9076, 1922, 3597, 1942, 1925, 3500, 24194, 14501, 18, 4475, 16, 1920, 58, 3]}]}
{"query": {"id": "q_4477", "content": "prostacyclin [SEP] tures of sulindac, owing to its lack of interference with renal prostacyclin synthesis. We describe 4 patients in whom hyperkalemia ranging ", "tokenized_content": [2, 4876, 23689, 1921, 3, 7431, 1918, 1927, 9596, 2762, 1948, 16, 10762, 1942, 2496, 3630, 1927, 8703, 1956, 4604, 4876, 23689, 1921, 4271, 18, 2038, 5993, 24, 2132, 1922, 8566, 3]}, "items": [{"id": "p_4477", "content": "Epoprostenol [SEP] A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTA", "score": 1, "type": null, "tokenized_content": [2, 15751, 2216, 24690, 1945, 3, 43, 15900, 1988, 1977, 43, 9974, 28194, 1930, 7042, 7163, 7883, 18, 2176, 1977, 7067, 4958, 23958, 2037, 4876, 1019, 3]}]}
{"query": {"id": "q_4478", "content": "hyperkalemia [SEP] th renal prostacyclin synthesis. We describe 4 patients in whom hyperkalemia ranging from 6.1 to 6.9 mEq/l developed within 3 to 8 days of s", "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 1913, 4604, 4876, 23689, 1921, 4271, 18, 2038, 5993, 24, 2132, 1922, 8566, 4194, 7640, 1952, 6026, 6485, 2037, 26, 18, 21, 1942, 26, 18, 3]}, "items": [{"id": "p_4478", "content": "Hyperkalemia [SEP] Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinicall", "score": 1, "type": null, "tokenized_content": [2, 4194, 7640, 1952, 6026, 3, 20756, 2149, 9057, 3110, 1922, 1920, 2877, 16, 2501, 3868, 2810, 1942, 9785, 4604, 11093, 18, 2176, 1977, 4378, 2535, 1024, 3]}]}
{"query": {"id": "q_4479", "content": "potassium [SEP]  8 days of sulindac administration. In all of them normal serum potassium levels reached within 2 to 4 days of stopping sulindac. As no o", "tokenized_content": [2, 9057, 3, 28, 3000, 1927, 9596, 2762, 1948, 4183, 18, 1922, 2136, 1927, 3581, 2791, 3256, 9057, 2428, 6690, 2651, 22, 1942, 24, 3000, 1927, 20225, 9596, 2762, 1948, 18, 3]}, "items": [{"id": "p_4479", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_4480", "content": "Ventricular tachyarrhythmias [SEP] Ventricular tachyarrhythmias during cesarean section after ritodrine therapy: interaction wi", "tokenized_content": [2, 6493, 12762, 9771, 18858, 10245, 15519, 3, 6493, 12762, 9771, 18858, 10245, 15519, 2409, 18334, 3314, 2256, 24019, 1986, 5773, 3181, 30, 2835, 11980, 3]}, "items": [{"id": "p_4480", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_4481", "content": "ritodrine [SEP] Ventricular tachyarrhythmias during cesarean section after ritodrine therapy: interaction with anesthetics.", "tokenized_content": [2, 24019, 1986, 5773, 3, 6493, 12762, 9771, 18858, 10245, 15519, 2409, 18334, 3314, 2256, 24019, 1986, 5773, 3181, 30, 2835, 1956, 25118, 18, 3]}, "items": [{"id": "p_4481", "content": "Ritodrine [SEP] An adrenergic beta-2 agonist used to control PREMATURE LABOR.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24019, 1986, 5773, 3, 1925, 13672, 4666, 17, 22, 7829, 2251, 1942, 2285, 9839, 3876, 18, 3]}]}
{"query": {"id": "q_4482", "content": "ritodrine [SEP] This case illustrates that patients receiving ritodrine for preterm labor may risk interactions between the residual be", "tokenized_content": [2, 24019, 1986, 5773, 3, 2052, 3087, 11897, 1988, 2132, 5962, 24019, 1986, 5773, 1958, 10435, 3876, 2278, 2565, 3719, 2192, 1920, 6615, 1998, 3]}, "items": [{"id": "p_4482", "content": "Ritodrine [SEP] An adrenergic beta-2 agonist used to control PREMATURE LABOR.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24019, 1986, 5773, 3, 1925, 13672, 4666, 17, 22, 7829, 2251, 1942, 2285, 9839, 3876, 18, 3]}]}
{"query": {"id": "q_4483", "content": "preterm labor [SEP] This case illustrates that patients receiving ritodrine for preterm labor may risk interactions between the residual betamimetic effects ", "tokenized_content": [2, 10435, 3876, 3, 2052, 3087, 11897, 1988, 2132, 5962, 24019, 1986, 5773, 1958, 10435, 3876, 2278, 2565, 3719, 2192, 1920, 6615, 4666, 7395, 15646, 2564, 3]}, "items": [{"id": "p_4483", "content": "Obstetric Labor, Premature [SEP] Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime d", "score": 1, "type": null, "tokenized_content": [2, 18902, 3876, 16, 9839, 3, 4727, 1927, 18902, 3876, 3119, 2576, 12, 2576, 5043, 13, 2308, 5394, 2256, 1920, 15722, 2258, 5433, 8978, 18, 1922, 5209, 16, 2176, 5110, 2673, 6995, 46, 3]}]}
{"query": {"id": "q_4484", "content": "cardiovascular complications [SEP] uring cesarean section. Such interactions may result in serious cardiovascular complications even after cessation of an infusion of ritodrine. Preoperative ", "tokenized_content": [2, 5321, 5021, 3, 3674, 1941, 18334, 3314, 18, 2427, 3719, 2278, 3211, 1922, 7433, 5321, 5021, 3385, 2256, 10975, 1927, 1925, 7386, 1927, 24019, 1986, 5773, 18, 8169, 3]}, "items": [{"id": "p_4484", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4485", "content": "potassium [SEP] tive assessment should focus on cardiovascular status and serum potassium level. Delaying induction of anesthesia should be considered wh", "tokenized_content": [2, 9057, 3, 8685, 1961, 4076, 3066, 3691, 1990, 5321, 3642, 1930, 3256, 9057, 2237, 18, 25252, 4408, 1927, 8871, 3066, 1998, 3311, 2003, 3]}, "items": [{"id": "p_4485", "content": "Potassium [SEP] An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cat", "score": 1, "type": null, "tokenized_content": [2, 9057, 3, 1925, 6149, 1922, 1920, 25178, 2210, 1927, 11570, 1956, 1925, 11241, 17530, 53, 16, 11241, 2529, 2282, 16, 1930, 11241, 3388, 3886, 18, 2119, 18, 2176, 1977, 1920, 18095, 3115, 3]}]}
{"query": {"id": "q_4486", "content": "ephedrine [SEP] eful fluid administration and cautious use of titrated doses of ephedrine are advised. After delivery of the infant, there should be no c", "tokenized_content": [2, 12717, 1919, 5773, 3, 8485, 1944, 5466, 4183, 1930, 23402, 2485, 1927, 22861, 5312, 1927, 12717, 1919, 5773, 2032, 19625, 18, 2256, 4868, 1927, 1920, 8125, 16, 2276, 3066, 1998, 3]}, "items": [{"id": "p_4486", "content": "Ephedrine [SEP] A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may als", "score": 1, "type": null, "tokenized_content": [2, 12717, 1919, 5773, 3, 43, 3037, 5188, 3812, 2435, 1922, 12717, 1919, 5524, 3132, 6102, 18, 11520, 2128, 13521, 5773, 1977, 1925, 15348, 18, 2176, 1977, 1925, 4595, 17, 1930, 4666, 17, 13672, 7829, 1988, 2278, 10534, 3]}]}
{"query": {"id": "q_4487", "content": "phenylephrine [SEP] ndication to the use of an alpha-adrenergic vasopressor such as phenylephrine to treat hypotensive patients with tachycardia.", "tokenized_content": [2, 27053, 3, 8026, 2959, 1942, 1920, 2485, 1927, 1925, 4595, 17, 13672, 17598, 1924, 2427, 1966, 27053, 1942, 2297, 12201, 3766, 2132, 1956, 17397, 18, 3]}, "items": [{"id": "p_4487", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_4488", "content": "hypotensive [SEP]  an alpha-adrenergic vasopressor such as phenylephrine to treat hypotensive patients with tachycardia.", "tokenized_content": [2, 12201, 3766, 3, 1925, 4595, 17, 13672, 17598, 1924, 2427, 1966, 27053, 1942, 2297, 12201, 3766, 2132, 1956, 17397, 18, 3]}, "items": [{"id": "p_4488", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4489", "content": "tachycardia [SEP] ressor such as phenylephrine to treat hypotensive patients with tachycardia.", "tokenized_content": [2, 17397, 3, 1995, 2204, 1005, 2427, 1966, 27053, 1942, 2297, 12201, 3766, 2132, 1956, 17397, 18, 3]}, "items": [{"id": "p_4489", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_4490", "content": "estrogen [SEP] histochemical, electron microscopic and morphometric studies of estrogen-induced rat prolactinomas after bromocriptine treatment.", "tokenized_content": [2, 7940, 3, 27816, 16, 4995, 10372, 1930, 21170, 2351, 1927, 7940, 17, 2719, 3067, 18386, 4956, 2256, 21392, 4093, 2053, 2311, 18, 3]}, "items": [{"id": "p_4490", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_4491", "content": "prolactinomas [SEP] on microscopic and morphometric studies of estrogen-induced rat prolactinomas after bromocriptine treatment.", "tokenized_content": [2, 18386, 4956, 3, 1990, 10372, 1930, 21170, 2351, 1927, 7940, 17, 2719, 3067, 18386, 4956, 2256, 21392, 4093, 2053, 2311, 18, 3]}, "items": [{"id": "p_4491", "content": "Prolactinoma [SEP] A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTO", "score": 1, "type": null, "tokenized_content": [2, 18386, 2954, 3, 43, 10621, 16530, 2154, 15989, 1036, 18386, 16, 4523, 1942, 4194, 15743, 11686, 3847, 18, 2535, 10952, 3951, 15969, 21588, 31, 9479, 1037, 3]}]}
{"query": {"id": "q_4492", "content": "bromocriptine [SEP] orphometric studies of estrogen-induced rat prolactinomas after bromocriptine treatment.", "tokenized_content": [2, 21392, 4093, 2053, 3, 2014, 2102, 5573, 2351, 1927, 7940, 17, 2719, 3067, 18386, 4956, 2256, 21392, 4093, 2053, 2311, 18, 3]}, "items": [{"id": "p_4492", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_4493", "content": "bromocriptine [SEP] To clarify the effects of bromocriptine on prolactinoma cells in vivo, immunohistochemical, ultrastruct", "tokenized_content": [2, 21392, 4093, 2053, 3, 1942, 11012, 1920, 2564, 1927, 21392, 4093, 2053, 1990, 18386, 2954, 2094, 1922, 3597, 16, 9885, 16, 5716, 6864, 3]}, "items": [{"id": "p_4493", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_4494", "content": "prolactinoma [SEP] To clarify the effects of bromocriptine on prolactinoma cells in vivo, immunohistochemical, ultrastructural and morphom", "tokenized_content": [2, 18386, 2954, 3, 1942, 11012, 1920, 2564, 1927, 21392, 4093, 2053, 1990, 18386, 2954, 2094, 1922, 3597, 16, 9885, 16, 19352, 1930, 3901, 1947, 3]}, "items": [{"id": "p_4494", "content": "Prolactinoma [SEP] A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTO", "score": 1, "type": null, "tokenized_content": [2, 18386, 2954, 3, 43, 10621, 16530, 2154, 15989, 1036, 18386, 16, 4523, 1942, 4194, 15743, 11686, 3847, 18, 2535, 10952, 3951, 15969, 21588, 31, 9479, 1037, 3]}]}
{"query": {"id": "q_4495", "content": "estrogen [SEP] al, ultrastructural and morphometrical analyses were applied to estrogen-induced rat prolactinoma cells 1 h and 6 h after injection of b", "tokenized_content": [2, 7940, 3, 1969, 16, 19352, 1930, 21170, 1923, 3247, 1985, 3730, 1942, 7940, 17, 2719, 3067, 18386, 2954, 2094, 21, 50, 1930, 26, 50, 2256, 4107, 1927, 44, 3]}, "items": [{"id": "p_4495", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_4496", "content": "adenoma [SEP] products for prolactin 6 h after bromocriptine treatment of the adenoma cells. An increase in the volume density of secretory granules ", "tokenized_content": [2, 16530, 3, 4461, 1958, 18386, 26, 50, 2256, 21392, 4093, 2053, 2311, 1927, 1920, 16530, 2094, 18, 1925, 2760, 1922, 1920, 3776, 3824, 1927, 11518, 12795, 3]}, "items": [{"id": "p_4496", "content": "Adenoma [SEP] A benign epithelial tumor with a glandular organization.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16530, 3, 43, 8867, 4944, 2798, 1956, 43, 21808, 5901, 18, 3]}]}
{"query": {"id": "q_4497", "content": "prednisolone [SEP] On two paradoxical side-effects of prednisolone in rats, ribosomal RNA biosyntheses, and a mechanism of action.", "tokenized_content": [2, 22025, 3, 1990, 2288, 24242, 4159, 17, 2564, 1927, 22025, 1922, 3615, 16, 11196, 3146, 7067, 18111, 16, 1930, 43, 2856, 1927, 4615, 18, 3]}, "items": [{"id": "p_4497", "content": "Prednisolone [SEP] A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routin", "score": 1, "type": null, "tokenized_content": [2, 22025, 3, 43, 14469, 1956, 1920, 3335, 3879, 1927, 1920, 14610, 18, 2176, 1977, 1920, 2838, 1927, 6259, 1958, 2136, 2961, 1922, 2154, 10276, 3]}]}
{"query": {"id": "q_4498", "content": "Liver enlargement [SEP] Liver enlargement and muscle wastage occurred in Wistar rats following the subcut", "tokenized_content": [2, 3568, 16363, 3, 3568, 16363, 1930, 3760, 1982, 3857, 2106, 4807, 1922, 15668, 3615, 2894, 1920, 5736, 1984, 3]}, "items": [{"id": "p_4498", "content": "Hepatomegaly [SEP] Enlargement of the liver.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5746, 19323, 3, 16363, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_4499", "content": "muscle wastage [SEP] Liver enlargement and muscle wastage occurred in Wistar rats following the subcutaneous administrati", "tokenized_content": [2, 3760, 1982, 3857, 2106, 3, 3568, 16363, 1930, 3760, 1982, 3857, 2106, 4807, 1922, 15668, 3615, 2894, 1920, 8634, 10473, 1968, 3]}, "items": [{"id": "p_4499", "content": "Muscular Atrophy [SEP] Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, pr", "score": 1, "type": null, "tokenized_content": [2, 12330, 10260, 3, 3135, 9538, 1922, 3081, 1930, 2529, 1927, 3760, 6989, 6966, 1956, 6619, 16, 3378, 1922, 2877, 9042, 16, 2014, 2894, 16704, 16, 2033, 3]}]}
{"query": {"id": "q_4500", "content": "prednisolone [SEP] red in Wistar rats following the subcutaneous administration of prednisolone. In the liver both the content of RNA and the biosynthesis of r", "tokenized_content": [2, 22025, 3, 2312, 1922, 15668, 3615, 2894, 1920, 8634, 4183, 1927, 22025, 18, 1922, 1920, 3568, 2321, 1920, 3919, 1927, 3146, 1930, 1920, 8132, 1927, 60, 3]}, "items": [{"id": "p_4500", "content": "Prednisolone [SEP] A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routin", "score": 1, "type": null, "tokenized_content": [2, 22025, 3, 43, 14469, 1956, 1920, 3335, 3879, 1927, 1920, 14610, 18, 2176, 1977, 1920, 2838, 1927, 6259, 1958, 2136, 2961, 1922, 2154, 10276, 3]}]}
{"query": {"id": "q_4501", "content": "midazolam [SEP] Possible intramuscular midazolam-associated cardiorespiratory arrest and death.", "tokenized_content": [2, 23380, 3, 3216, 16774, 23380, 17, 2458, 28158, 8048, 1930, 3539, 18, 3]}, "items": [{"id": "p_4501", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_4502", "content": "cardiorespiratory arrest [SEP] Possible intramuscular midazolam-associated cardiorespiratory arrest and death.", "tokenized_content": [2, 28158, 8048, 3, 3216, 16774, 23380, 17, 2458, 28158, 8048, 1930, 3539, 18, 3]}, "items": [{"id": "p_4502", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_4503", "content": "death [SEP] intramuscular midazolam-associated cardiorespiratory arrest and death.", "tokenized_content": [2, 3539, 3, 16774, 23380, 17, 2458, 28158, 8048, 1930, 3539, 18, 3]}, "items": [{"id": "p_4503", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_4504", "content": "Midazolam hydrochloride [SEP] Midazolam hydrochloride is commonly used for dental or endoscopic procedures. Although ", "tokenized_content": [2, 23380, 16675, 3, 23380, 16675, 1977, 5384, 2251, 1958, 7915, 2014, 10448, 4869, 18, 2876, 3]}, "items": [{"id": "p_4504", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_4505", "content": "cardiovascular depression [SEP] y, intravenous administration is known to cause respiratory and cardiovascular depression. This report describes the first published case of cardiorespir", "tokenized_content": [2, 5321, 4621, 3, 67, 16, 7307, 4183, 1977, 3171, 1942, 3936, 5481, 1930, 5321, 4621, 18, 2052, 3809, 9845, 1920, 2561, 4586, 3087, 1927, 26612, 18589, 1996, 3]}, "items": [{"id": "p_4505", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4506", "content": "cardiorespiratory arrest [SEP] r depression. This report describes the first published case of cardiorespiratory arrest and death associated with intramuscular administration of midaz", "tokenized_content": [2, 28158, 8048, 3, 60, 4621, 18, 2052, 3809, 9845, 1920, 2561, 4586, 3087, 1927, 28158, 8048, 1930, 3539, 2458, 1956, 16774, 4183, 1927, 3953, 3408, 3]}, "items": [{"id": "p_4506", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_4507", "content": "death [SEP] cribes the first published case of cardiorespiratory arrest and death associated with intramuscular administration of midazolam. Info", "tokenized_content": [2, 3539, 3, 3828, 5873, 1036, 1920, 2561, 4586, 3087, 1927, 28158, 8048, 1930, 3539, 2458, 1956, 16774, 4183, 1927, 23380, 18, 29091, 3]}, "items": [{"id": "p_4507", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_4508", "content": "midazolam [SEP] rrest and death associated with intramuscular administration of midazolam. Information regarding midazolam use is reviewed to provide rec", "tokenized_content": [2, 23380, 3, 5162, 2158, 1930, 3539, 2458, 1956, 16774, 4183, 1927, 23380, 18, 2988, 4667, 23380, 2485, 1977, 5487, 1942, 3394, 2090, 3]}, "items": [{"id": "p_4508", "content": "Midazolam [SEP] A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endosco", "score": 1, "type": null, "tokenized_content": [2, 23380, 3, 43, 3662, 17, 8290, 25810, 3153, 17, 28514, 2838, 1956, 28932, 1930, 14701, 8396, 3879, 18, 2176, 1977, 2251, 1922, 25375, 16, 4435, 3782, 16, 22868, 4879, 3]}]}
{"query": {"id": "q_4509", "content": "epilepsy [SEP] Serial epilepsy caused by levodopa/carbidopa administration in two patients on ", "tokenized_content": [2, 9741, 3, 9285, 9741, 4189, 2007, 26723, 19, 3697, 15072, 4302, 4183, 1922, 2288, 2132, 1990, 3]}, "items": [{"id": "p_4509", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_4510", "content": "levodopa/carbidopa [SEP] Serial epilepsy caused by levodopa/carbidopa administration in two patients on hemodialysis.", "tokenized_content": [2, 26723, 19, 3697, 15072, 4302, 3, 9285, 9741, 4189, 2007, 26723, 19, 3697, 15072, 4302, 4183, 1922, 2288, 2132, 1990, 15932, 18, 3]}, "items": [{"id": "p_4510", "content": "carbidopa, levodopa drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3697, 15072, 4302, 16, 26723, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_4511", "content": "chronic renal failure [SEP] with similar clinical features are presented: both patients had chronic renal failure, on hemodialysis for many years but recently begun on a high-fl", "tokenized_content": [2, 3724, 4604, 4574, 3, 1956, 2551, 2535, 4075, 2032, 3549, 30, 2321, 2132, 2430, 3724, 4604, 4574, 16, 1990, 15932, 1958, 3086, 2739, 2308, 3998, 18619, 1990, 43, 2149, 17, 3]}, "items": [{"id": "p_4511", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_4512", "content": "carbidopa/levodopa [SEP] cently begun on a high-flux dialyzer; both had been receiving a carbidopa/levodopa preparation; and both had the onset of hallucinosis and recurre", "tokenized_content": [2, 3697, 15072, 4302, 19, 26723, 3, 3208, 1954, 18619, 1990, 43, 2149, 17, 8220, 7588, 21536, 31, 2321, 2430, 2252, 5962, 43, 3697, 15072, 4302, 19, 26723, 6040, 31, 1930, 3]}, "items": [{"id": "p_4512", "content": "carbidopa, levodopa drug combination [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3697, 15072, 4302, 16, 26723, 2838, 3921, 3, 3]}]}
{"query": {"id": "q_4513", "content": "hallucinosis [SEP] ing a carbidopa/levodopa preparation; and both had the onset of hallucinosis and recurrent seizures, which were refractory to anticonvulsant", "tokenized_content": [2, 20958, 11096, 1937, 3, 30393, 43, 3697, 15072, 4302, 19, 26723, 6040, 31, 1930, 2321, 2430, 1920, 4727, 1927, 20958, 11096, 1937, 1930, 7457, 10060, 16, 2154, 1985, 10923, 1942, 3]}, "items": [{"id": "p_4513", "content": "Mental Disorders [SEP] Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of tho", "score": 1, "type": null, "tokenized_content": [2, 5018, 4414, 3, 7652, 6455, 2014, 3902, 16687, 2007, 13630, 1036, 1922, 1920, 7810, 1923, 2585, 3198, 5985, 1966, 6754, 1927, 1913, 1037, 3]}]}
{"query": {"id": "q_4514", "content": "seizures [SEP] eparation; and both had the onset of hallucinosis and recurrent seizures, which were refractory to anticonvulsants. The first patient di", "tokenized_content": [2, 10060, 3, 15369, 5524, 1929, 31, 1930, 2321, 2430, 1920, 4727, 1927, 20958, 11096, 1937, 1930, 7457, 10060, 16, 2154, 1985, 10923, 1942, 26572, 2356, 18, 1920, 2561, 2774, 2137, 3]}, "items": [{"id": "p_4514", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4515", "content": "vitamin B6 [SEP] patient had a dramatic recovery following the administration of vitamin B6. Neither patient was considered to have a renal state sufficien", "tokenized_content": [2, 6111, 11750, 3, 2774, 2430, 43, 10889, 5241, 2894, 1920, 4183, 1927, 6111, 11750, 18, 7132, 2774, 1982, 3311, 1942, 2162, 43, 4604, 3360, 18064, 2478, 1917, 3]}, "items": [{"id": "p_4515", "content": "Vitamin B 6 [SEP] VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the", "score": 1, "type": null, "tokenized_content": [2, 6111, 44, 26, 3, 6111, 44, 26, 11238, 1942, 2980, 28609, 26037, 12, 4369, 24828, 9754, 1021, 31, 24828, 23859, 31, 10, 24828, 2325, 3812, 13, 1988, 2032, 8536, 9076, 2007, 1920, 3]}]}
{"query": {"id": "q_4516", "content": "L-alpha-glyceryl-phosphorylcholine [SEP] Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.", "tokenized_content": [2, 54, 17, 4595, 17, 7757, 2199, 17, 12556, 11603, 3, 2495, 1927, 54, 17, 4595, 17, 7757, 2199, 17, 12556, 11603, 1990, 14701, 7156, 4189, 2007, 25392, 10173, 25157, 18, 3]}, "items": [{"id": "p_4516", "content": "Glycerylphosphorylcholine [SEP] A component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (", "score": 1, "type": null, "tokenized_content": [2, 7757, 2199, 10614, 2199, 11603, 3, 43, 4594, 1927, 23842, 1036, 2014, 18430, 1953, 2925, 16, 1922, 2154, 1920, 2288, 8275, 2671, 1927, 9244, 2032, 9603, 2828, 1956, 5934, 4576, 18, 12, 3]}]}
{"query": {"id": "q_4517", "content": "amnesia [SEP] Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.", "tokenized_content": [2, 14701, 7156, 3, 2495, 1927, 54, 17, 4595, 17, 7757, 2199, 17, 12556, 11603, 1990, 14701, 7156, 4189, 2007, 25392, 10173, 25157, 18, 3]}, "items": [{"id": "p_4517", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_4518", "content": "scopolamine [SEP] fect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.", "tokenized_content": [2, 25392, 10173, 25157, 3, 16688, 1031, 1927, 54, 17, 4595, 17, 7757, 2199, 17, 12556, 11603, 1990, 14701, 7156, 4189, 2007, 25392, 10173, 25157, 18, 3]}, "items": [{"id": "p_4518", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_4519", "content": "L-alpha-glycerylphosphorylcholine [SEP] The present study was carried out to test the effects of L-alpha-glycerylphosphorylcholine (L-alpha-GFC) on memory impairment induced by scopolamine in ma", "tokenized_content": [2, 54, 17, 4595, 17, 7757, 2199, 10614, 2199, 11603, 3, 1920, 2481, 2161, 1982, 4371, 2397, 1942, 2648, 1920, 2564, 1927, 54, 17, 4595, 17, 7757, 2199, 10614, 2199, 11603, 3]}, "items": [{"id": "p_4519", "content": "Glycerylphosphorylcholine [SEP] A component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (", "score": 1, "type": null, "tokenized_content": [2, 7757, 2199, 10614, 2199, 11603, 3, 43, 4594, 1927, 23842, 1036, 2014, 18430, 1953, 2925, 16, 1922, 2154, 1920, 2288, 8275, 2671, 1927, 9244, 2032, 9603, 2828, 1956, 5934, 4576, 18, 12, 3]}]}
{"query": {"id": "q_4520", "content": "L-alpha-GFC [SEP] d out to test the effects of L-alpha-glycerylphosphorylcholine (L-alpha-GFC) on memory impairment induced by scopolamine in man. Thirty-two", "tokenized_content": [2, 54, 17, 4595, 17, 9281, 1030, 3, 46, 2397, 1942, 2648, 1920, 2564, 1927, 54, 17, 4595, 17, 7757, 2199, 10614, 2199, 11603, 12, 54, 17, 4595, 17, 9281, 1030, 3]}, "items": [{"id": "p_4520", "content": "Glycerylphosphorylcholine [SEP] A component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (", "score": 1, "type": null, "tokenized_content": [2, 7757, 2199, 10614, 2199, 11603, 3, 43, 4594, 1927, 23842, 1036, 2014, 18430, 1953, 2925, 16, 1922, 2154, 1920, 2288, 8275, 2671, 1927, 9244, 2032, 9603, 2828, 1956, 5934, 4576, 18, 12, 3]}]}
{"query": {"id": "q_4521", "content": "memory impairment [SEP] e effects of L-alpha-glycerylphosphorylcholine (L-alpha-GFC) on memory impairment induced by scopolamine in man. Thirty-two healthy young volunte", "tokenized_content": [2, 4525, 6159, 3, 47, 2564, 1927, 54, 17, 4595, 17, 7757, 2199, 10614, 2199, 11603, 12, 54, 17, 4595, 17, 9281, 1030, 13, 1990, 4525, 6159, 2719, 2007, 25392, 10173, 3]}, "items": [{"id": "p_4521", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_4522", "content": "scopolamine [SEP] phosphorylcholine (L-alpha-GFC) on memory impairment induced by scopolamine in man. Thirty-two healthy young volunteers were randomly alloc", "tokenized_content": [2, 25392, 10173, 25157, 3, 12556, 11603, 12, 54, 17, 4595, 17, 9281, 1030, 13, 1990, 4525, 6159, 2719, 2007, 25392, 10173, 25157, 1922, 2323, 18, 9942, 17, 2288, 4097, 4201, 3]}, "items": [{"id": "p_4522", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_4523", "content": "impairment of attention and memory [SEP] ings of this study indicate that the drug is able to antagonize impairment of attention and memory induced by scopolamine.", "tokenized_content": [2, 6159, 1927, 4976, 1930, 4525, 3, 30393, 1036, 1927, 2052, 2161, 3579, 1988, 1920, 2838, 1977, 4236, 1942, 28104, 6159, 1927, 4976, 1930, 4525, 2719, 2007, 25392, 10173, 25157, 18, 3]}, "items": [{"id": "p_4523", "content": "Memory Disorders [SEP] Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory", "score": 1, "type": null, "tokenized_content": [2, 4525, 4414, 3, 12654, 1922, 13801, 1941, 1925, 19297, 16, 1922, 1920, 7521, 1927, 1925, 5815, 19297, 16, 2014, 1922, 1920, 8717, 1927, 1925, 19297, 18, 4525, 3]}]}
{"query": {"id": "q_4524", "content": "Seizures [SEP] Seizures induced by the cocaine metabolite benzoylecgonine in rats.", "tokenized_content": [2, 10060, 3, 10060, 2719, 2007, 1920, 9045, 9483, 19225, 6752, 1030, 3827, 8635, 2912, 1922, 3615, 18, 3]}, "items": [{"id": "p_4524", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4525", "content": "cocaine [SEP] Seizures induced by the cocaine metabolite benzoylecgonine in rats.", "tokenized_content": [2, 9045, 3, 10060, 2719, 2007, 1920, 9045, 9483, 19225, 6752, 1030, 3827, 8635, 2912, 1922, 3615, 18, 3]}, "items": [{"id": "p_4525", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4526", "content": "benzoylecgonine [SEP] Seizures induced by the cocaine metabolite benzoylecgonine in rats.", "tokenized_content": [2, 19225, 6752, 1030, 3827, 8635, 2912, 3, 10060, 2719, 2007, 1920, 9045, 9483, 19225, 6752, 1030, 3827, 8635, 2912, 1922, 3615, 18, 3]}, "items": [{"id": "p_4526", "content": "benzoylecgonine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 19225, 6752, 1030, 3827, 8635, 2912, 3, 3]}]}
{"query": {"id": "q_4527", "content": "cocaine [SEP] The half-life (t1/2) of cocaine is relatively short, but some of the consequences of its use, s", "tokenized_content": [2, 9045, 3, 1920, 4768, 17, 3308, 12, 6197, 19, 22, 13, 1927, 9045, 1977, 4322, 3662, 16, 2308, 2673, 1927, 1920, 7080, 1927, 2496, 2485, 16, 61, 3]}, "items": [{"id": "p_4527", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4528", "content": "seizures [SEP] atively short, but some of the consequences of its use, such as seizures and strokes, can occur hours after exposure. This led us to hyp", "tokenized_content": [2, 10060, 3, 2019, 5102, 3662, 16, 2308, 2673, 1927, 1920, 7080, 1927, 2496, 2485, 16, 2427, 1966, 10060, 1930, 21655, 16, 2112, 4704, 3967, 2256, 3395, 18, 2052, 4866, 2022, 3]}, "items": [{"id": "p_4528", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4529", "content": "strokes [SEP] , but some of the consequences of its use, such as seizures and strokes, can occur hours after exposure. This led us to hypothesize tha", "tokenized_content": [2, 21655, 3, 16, 2308, 2673, 1927, 1920, 7080, 1927, 2496, 2485, 16, 2427, 1966, 10060, 1930, 21655, 16, 2112, 4704, 3967, 2256, 3395, 18, 2052, 4866, 2022, 1942, 12880, 21513, 3]}, "items": [{"id": "p_4529", "content": "Stroke [SEP] A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA o", "score": 1, "type": null, "tokenized_content": [2, 5235, 3, 43, 2210, 1927, 6598, 2961, 4378, 2007, 12446, 16, 2447, 17, 4772, 13042, 3257, 1927, 7605, 2347, 2810, 1942, 3068, 7716, 57, 3]}]}
{"query": {"id": "q_4530", "content": "benzoylecgonine [SEP]  We evaluated the potential of the major metabolite of cocaine, benzoylecgonine (BE), to cause seizures. Two separate equimolar doses (0.2 and ", "tokenized_content": [2, 19225, 6752, 1030, 3827, 8635, 2912, 3, 2038, 3747, 1920, 2889, 1927, 1920, 3044, 9483, 1927, 9045, 16, 19225, 6752, 1030, 3827, 8635, 2912, 12, 1998, 13, 16, 1942, 3936, 3]}, "items": [{"id": "p_4530", "content": "benzoylecgonine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 19225, 6752, 1030, 3827, 8635, 2912, 3, 3]}]}
{"query": {"id": "q_4531", "content": "BE [SEP]  potential of the major metabolite of cocaine, benzoylecgonine (BE), to cause seizures. Two separate equimolar doses (0.2 and 0.4 ", "tokenized_content": [2, 1998, 3, 2889, 1927, 1920, 3044, 9483, 1927, 9045, 16, 19225, 6752, 1030, 3827, 8635, 2912, 12, 1998, 13, 16, 1942, 3936, 10060, 18, 2288, 5850, 25747, 5312, 12, 20, 3]}, "items": [{"id": "p_4531", "content": "benzoylecgonine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 19225, 6752, 1030, 3827, 8635, 2912, 3, 3]}]}
{"query": {"id": "q_4532", "content": "seizure [SEP] atively short, but some of the consequences of its use, such as seizures and strokes, can occur hours after exposure. This led us to hy", "tokenized_content": [2, 11015, 3, 2019, 5102, 3662, 16, 2308, 2673, 1927, 1920, 7080, 1927, 2496, 2485, 16, 2427, 1966, 10060, 1930, 21655, 16, 2112, 4704, 3967, 2256, 3395, 18, 2052, 4866, 2022, 3]}, "items": [{"id": "p_4532", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4533", "content": "death [SEP]  characterized as brief, generalized, and tonic and resulted in death, those induced by BE were prolonged, often multiple and mixed i", "tokenized_content": [2, 3539, 3, 4378, 1966, 5310, 16, 9612, 16, 1930, 16887, 1930, 4306, 1922, 3539, 16, 2690, 2719, 2007, 1998, 1985, 7171, 16, 3868, 3137, 1930, 4985, 51, 3]}, "items": [{"id": "p_4533", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_4534", "content": "amphetamine [SEP] Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in roden", "tokenized_content": [2, 19057, 3, 6202, 3316, 19057, 17, 2719, 18034, 4205, 13165, 7964, 3558, 1922, 6275, 1917, 3]}, "items": [{"id": "p_4534", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_4535", "content": "neurotoxicity [SEP] Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an exc", "tokenized_content": [2, 18034, 3, 6202, 3316, 19057, 17, 2719, 18034, 4205, 13165, 7964, 3558, 1922, 12035, 2007, 7518, 30421, 9171, 1006, 16, 1925, 3619, 3]}, "items": [{"id": "p_4535", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4536", "content": "dopamine [SEP] ction against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antago", "tokenized_content": [2, 7964, 3, 3369, 2001, 3316, 19057, 17, 2719, 18034, 4205, 13165, 7964, 3558, 1922, 12035, 2007, 7518, 30421, 9171, 1006, 16, 1925, 11237, 3835, 2687, 4942, 10421, 3]}, "items": [{"id": "p_4536", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4537", "content": "LY274614 [SEP] ed neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist.", "tokenized_content": [2, 7518, 30421, 9171, 1006, 3, 3347, 18034, 4205, 13165, 7964, 3558, 1922, 12035, 2007, 7518, 30421, 9171, 1006, 16, 1925, 11237, 3835, 2687, 8151, 18, 3]}, "items": [{"id": "p_4537", "content": "LY 274614 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7518, 23092, 9171, 1006, 3, 3]}]}
{"query": {"id": "q_4538", "content": "amino acid [SEP] striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist.", "tokenized_content": [2, 3835, 2687, 3, 13165, 7964, 3558, 1922, 12035, 2007, 7518, 30421, 9171, 1006, 16, 1925, 11237, 3835, 2687, 8151, 18, 3]}, "items": [{"id": "p_4538", "content": "Amino Acids [SEP] Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits", "score": 1, "type": null, "tokenized_content": [2, 3835, 4576, 3, 6805, 4300, 1988, 4933, 5531, 1925, 3835, 12, 17, 15410, 13, 1930, 43, 9943, 12, 17, 20729, 13, 2210, 18, 7639, 4595, 17, 3835, 4576, 2032, 1920, 6991, 3]}]}
{"query": {"id": "q_4539", "content": "LY274614 [SEP] LY274614, 3SR,4aRS,6SR,8aRS-6-[phosphonomethyl]decahydr oisoquinoline-3-", "tokenized_content": [2, 7518, 30421, 9171, 1006, 3, 7518, 30421, 9171, 1006, 16, 27972, 1005, 16, 6169, 5675, 16, 26, 19025, 16, 13396, 5675, 17, 26, 17, 37, 8078, 11873, 21312, 39, 2344, 3]}, "items": [{"id": "p_4539", "content": "LY 274614 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7518, 23092, 9171, 1006, 3, 3]}]}
{"query": {"id": "q_4540", "content": "3SR,4aRS,6SR,8aRS-6-[phosphonomethyl]decahydr oisoquinoline-3- carboxylic acid [SEP] LY274614, 3SR,4aRS,6SR,8aRS-6-[phosphonomethyl]decahydr oisoquinoline-3- carboxylic acid, has been described as a potent antagonist of the N-methyl-D-as", "tokenized_content": [2, 27972, 1005, 16, 6169, 5675, 16, 26, 19025, 16, 13396, 5675, 17, 26, 17, 37, 8078, 11873, 21312, 39, 2344, 5945, 2584, 1005, 25166, 2204, 11072, 8419, 17, 23, 17, 3]}, "items": [{"id": "p_4540", "content": "LY 274614 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7518, 23092, 9171, 1006, 3, 3]}]}
{"query": {"id": "q_4541", "content": "N-methyl-D-aspartate [SEP] rboxylic acid, has been described as a potent antagonist of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. Here its ability to antag", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 6160, 6644, 1935, 2687, 16, 2258, 2252, 2910, 1966, 43, 6828, 8151, 1927, 1920, 56, 17, 4963, 17, 46, 17, 12878, 12, 3]}, "items": [{"id": "p_4541", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_4542", "content": "NMDA [SEP] n described as a potent antagonist of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. Here its ability to antagonize ", "tokenized_content": [2, 10976, 3, 56, 2910, 1966, 43, 6828, 8151, 1927, 1920, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 8856, 1927, 7627, 3148, 18, 3410, 2496, 3682, 1942, 28104, 3]}, "items": [{"id": "p_4542", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_4543", "content": "glutamate [SEP] potent antagonist of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. Here its ability to antagonize the prolonged depletio", "tokenized_content": [2, 7627, 3, 6828, 8151, 1927, 1920, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 8856, 1927, 7627, 3148, 18, 3410, 2496, 3682, 1942, 28104, 1920, 7171, 8863, 3940, 3]}, "items": [{"id": "p_4543", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_4544", "content": "dopamine [SEP] ptor. Here its ability to antagonize the prolonged depletion of dopamine in the striatum by amphetamine in iprindole-treated rats is rep", "tokenized_content": [2, 7964, 3, 4401, 1924, 18, 3410, 2496, 3682, 1942, 28104, 1920, 7171, 6882, 1927, 7964, 1922, 1920, 11259, 2007, 19057, 1922, 27194, 19554, 17, 2868, 3615, 1977, 3073, 3]}, "items": [{"id": "p_4544", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4545", "content": "amphetamine [SEP] tagonize the prolonged depletion of dopamine in the striatum by amphetamine in iprindole-treated rats is reported. A single 18.4 mg/kg (i.p", "tokenized_content": [2, 19057, 3, 5218, 13339, 6931, 1920, 7171, 6882, 1927, 7964, 1922, 1920, 11259, 2007, 19057, 1922, 27194, 19554, 17, 2868, 3615, 1977, 2568, 18, 43, 2957, 2654, 18, 24, 2786, 3]}, "items": [{"id": "p_4545", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_4546", "content": "iprindole [SEP] olonged depletion of dopamine in the striatum by amphetamine in iprindole-treated rats is reported. A single 18.4 mg/kg (i.p.) dose of (+", "tokenized_content": [2, 27194, 19554, 3, 2865, 18771, 1007, 6882, 1927, 7964, 1922, 1920, 11259, 2007, 19057, 1922, 27194, 19554, 17, 2868, 3615, 1977, 2568, 18, 43, 2957, 2654, 18, 24, 2786, 19, 3]}, "items": [{"id": "p_4546", "content": "Iprindole [SEP] A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sed", "score": 1, "type": null, "tokenized_content": [2, 27194, 19554, 3, 43, 12258, 13153, 14183, 1988, 2258, 7728, 1930, 7947, 2551, 1942, 2690, 1927, 15665, 1997, 14302, 26561, 16, 2308, 2258, 2444, 5015, 20330, 7801, 18979, 1930, 6276, 3]}]}
{"query": {"id": "q_4547", "content": "dizocilpine [SEP] longed depletion of dopamine in the striatum was antagonized by dizocilpine (MK-801, a non-competitive antagonist of NMDA receptors) or by ", "tokenized_content": [2, 2137, 13642, 10401, 12184, 3, 15773, 1007, 6882, 1927, 7964, 1922, 1920, 11259, 1982, 29368, 2007, 2137, 13642, 10401, 12184, 12, 10539, 17, 23858, 16, 43, 2447, 17, 10362, 8151, 3]}, "items": [{"id": "p_4547", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_4548", "content": "MK-801 [SEP] ion of dopamine in the striatum was antagonized by dizocilpine (MK-801, a non-competitive antagonist of NMDA receptors) or by LY274614", "tokenized_content": [2, 10539, 17, 23858, 3, 4755, 1927, 7964, 1922, 1920, 11259, 1982, 29368, 2007, 2137, 13642, 10401, 12184, 12, 10539, 17, 23858, 16, 43, 2447, 17, 10362, 8151, 1927, 10976, 4086, 3]}, "items": [{"id": "p_4548", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_4549", "content": "methamphetamine [SEP]  dopamine in the striatum in mice, given multiple injections of methamphetamine, was also antagonized dose-dependently and completely by LY2746", "tokenized_content": [2, 20375, 3, 7964, 1922, 1920, 11259, 1922, 2518, 16, 3258, 3137, 8775, 1927, 20375, 16, 1982, 2222, 29368, 3253, 17, 19898, 1930, 5796, 2007, 7518, 30421, 1016, 3]}, "items": [{"id": "p_4549", "content": "Methamphetamine [SEP] A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is ", "score": 1, "type": null, "tokenized_content": [2, 20375, 3, 43, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 1956, 7728, 1930, 7947, 2551, 1942, 20256, 1931, 18996, 18, 1920, 4064, 2115, 2386, 1977, 3]}]}
{"query": {"id": "q_4550", "content": "neurotoxic [SEP] mpletely by LY274614. The data strengthen the evidence that the neurotoxic effect of amphetamine and related compounds toward nigrostriata", "tokenized_content": [2, 20919, 3, 26259, 11555, 1954, 2007, 7518, 30421, 9171, 1006, 18, 1920, 2230, 17976, 1920, 3095, 1988, 1920, 20919, 2495, 1927, 19057, 1930, 2712, 4300, 4205, 17452, 17414, 3801, 1019, 3]}, "items": [{"id": "p_4550", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4551", "content": "pyridoxine [SEP] Neonatal pyridoxine responsive convulsions due to isoniazid therapy.", "tokenized_content": [2, 24828, 9754, 1021, 3, 7985, 24828, 9754, 1021, 8487, 4772, 19389, 2810, 1942, 28383, 3181, 18, 3]}, "items": [{"id": "p_4551", "content": "Pyridoxine [SEP] The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, n", "score": 1, "type": null, "tokenized_content": [2, 24828, 9754, 1021, 3, 1920, 24, 17, 8570, 2386, 1927, 6111, 44, 26, 2154, 1977, 9076, 1942, 24828, 23859, 5413, 2154, 1977, 43, 22051, 1958, 4271, 1927, 3835, 4576, 16, 56, 3]}]}
{"query": {"id": "q_4552", "content": "convulsions [SEP] Neonatal pyridoxine responsive convulsions due to isoniazid therapy.", "tokenized_content": [2, 4772, 19389, 3, 7985, 24828, 9754, 1021, 8487, 4772, 19389, 2810, 1942, 28383, 3181, 18, 3]}, "items": [{"id": "p_4552", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4553", "content": "isoniazid [SEP] Neonatal pyridoxine responsive convulsions due to isoniazid therapy.", "tokenized_content": [2, 28383, 3, 7985, 24828, 9754, 1021, 8487, 4772, 19389, 2810, 1942, 28383, 3181, 18, 3]}, "items": [{"id": "p_4553", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_4554", "content": "isoniazid [SEP] A 17-day-old infant on isoniazid therapy 13 mg/kg daily from birth because of maternal tuberculo", "tokenized_content": [2, 28383, 3, 43, 2752, 17, 3007, 17, 4156, 8125, 1990, 28383, 3181, 2590, 2786, 19, 3621, 4692, 2037, 5043, 2882, 1927, 5509, 7687, 1944, 1037, 3]}, "items": [{"id": "p_4554", "content": "Isoniazid [SEP] Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28383, 3, 13021, 5899, 2251, 5985, 1966, 43, 7687, 11677, 3857, 2002, 18, 2176, 4497, 1920, 2311, 1927, 6259, 1958, 8449, 18, 3]}]}
{"query": {"id": "q_4555", "content": "tuberculosis [SEP] isoniazid therapy 13 mg/kg daily from birth because of maternal tuberculosis was admitted after 4 days of clonic fits. No underlying infecti", "tokenized_content": [2, 8449, 3, 28383, 3181, 2590, 2786, 19, 3621, 4692, 2037, 5043, 2882, 1927, 5509, 8449, 1982, 9723, 2256, 24, 3000, 1927, 6138, 1935, 13875, 18, 2239, 5030, 15119, 1033, 3]}, "items": [{"id": "p_4555", "content": "Tuberculosis [SEP] Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8449, 3, 2967, 1927, 1920, 7465, 3902, 1927, 2323, 1930, 2303, 3555, 4189, 2007, 3038, 1927, 16389, 18, 3]}]}
{"query": {"id": "q_4556", "content": "clonic fits [SEP] h because of maternal tuberculosis was admitted after 4 days of clonic fits. No underlying infective or biochemical cause could be found. T", "tokenized_content": [2, 6138, 1935, 13875, 3, 50, 2882, 1927, 5509, 8449, 1982, 9723, 2256, 24, 3000, 1927, 6138, 1935, 13875, 18, 2239, 5030, 20905, 2014, 6503, 3936, 2578, 1998, 2435, 18, 62, 3]}, "items": [{"id": "p_4556", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4557", "content": "fits [SEP] se of maternal tuberculosis was admitted after 4 days of clonic fits. No underlying infective or biochemical cause could be found. T", "tokenized_content": [2, 13875, 3, 2058, 1927, 5509, 8449, 1982, 9723, 2256, 24, 3000, 1927, 6138, 1935, 13875, 18, 2239, 5030, 20905, 2014, 6503, 3936, 2578, 1998, 2435, 18, 62, 3]}, "items": [{"id": "p_4557", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4558", "content": "pyridoxine [SEP] . The fits ceased within 4 hours of administering intramuscular pyridoxine, suggesting an aetiology of pyridoxine deficiency secondary to ", "tokenized_content": [2, 24828, 9754, 1021, 3, 18, 1920, 13875, 14292, 4127, 1007, 2651, 24, 3967, 1927, 20921, 16774, 24828, 9754, 1021, 16, 3783, 1925, 22717, 1927, 24828, 9754, 1021, 6179, 4067, 1942, 3]}, "items": [{"id": "p_4558", "content": "Pyridoxine [SEP] The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, n", "score": 1, "type": null, "tokenized_content": [2, 24828, 9754, 1021, 3, 1920, 24, 17, 8570, 2386, 1927, 6111, 44, 26, 2154, 1977, 9076, 1942, 24828, 23859, 5413, 2154, 1977, 43, 22051, 1958, 4271, 1927, 3835, 4576, 16, 56, 3]}]}
{"query": {"id": "q_4559", "content": "phenylephrine [SEP] Reversal by phenylephrine of the beneficial effects of intravenous nitroglycerin in patie", "tokenized_content": [2, 27053, 3, 12393, 2007, 27053, 1927, 1920, 6928, 2564, 1927, 7307, 8686, 14966, 1921, 1922, 2091, 1021, 3]}, "items": [{"id": "p_4559", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_4560", "content": "nitroglycerin [SEP] ersal by phenylephrine of the beneficial effects of intravenous nitroglycerin in patients with acute myocardial infarction.", "tokenized_content": [2, 8686, 14966, 1921, 3, 22877, 1923, 2007, 27053, 1927, 1920, 6928, 2564, 1927, 7307, 8686, 14966, 1921, 1922, 2132, 1956, 3939, 6497, 8358, 18, 3]}, "items": [{"id": "p_4560", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_4561", "content": "acute myocardial infarction [SEP] eneficial effects of intravenous nitroglycerin in patients with acute myocardial infarction.", "tokenized_content": [2, 3939, 6497, 8358, 3, 2066, 7726, 4889, 2564, 1927, 7307, 8686, 14966, 1921, 1922, 2132, 1956, 3939, 6497, 8358, 18, 3]}, "items": [{"id": "p_4561", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_4562", "content": "Nitroglycerin [SEP] Nitroglycerin has been shown to reduce ST-segment elevation during acute myoc", "tokenized_content": [2, 8686, 14966, 1921, 3, 8686, 14966, 1921, 2258, 2252, 2522, 1942, 4412, 1955, 17, 5367, 8644, 2409, 3939, 15924, 1030, 3]}, "items": [{"id": "p_4562", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_4563", "content": "acute myocardial infarction [SEP] roglycerin has been shown to reduce ST-segment elevation during acute myocardial infarction, an effect potentiated in the dog by agents that reverse nitrog", "tokenized_content": [2, 3939, 6497, 8358, 3, 20443, 7995, 1921, 2258, 2252, 2522, 1942, 4412, 1955, 17, 5367, 8644, 2409, 3939, 6497, 8358, 16, 1925, 2495, 20419, 1922, 1920, 6567, 2007, 4820, 1988, 3]}, "items": [{"id": "p_4563", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_4564", "content": "nitroglycerin [SEP] rction, an effect potentiated in the dog by agents that reverse nitroglycerin-induced hypotension. Our study was designed to determine the ef", "tokenized_content": [2, 8686, 14966, 1921, 3, 14001, 2001, 16, 1925, 2495, 20419, 1922, 1920, 6567, 2007, 4820, 1988, 5267, 8686, 14966, 1921, 17, 2719, 16453, 18, 2342, 2161, 1982, 4609, 1942, 3415, 3]}, "items": [{"id": "p_4564", "content": "Nitroglycerin [SEP] A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is als", "score": 1, "type": null, "tokenized_content": [2, 8686, 14966, 1921, 3, 43, 15842, 28194, 2154, 23632, 1036, 16961, 23540, 1937, 2007, 9868, 13504, 9075, 16526, 1930, 11187, 9410, 5016, 18, 2176, 1977, 10534, 3]}]}
{"query": {"id": "q_4565", "content": "hypotension [SEP] ntiated in the dog by agents that reverse nitroglycerin-induced hypotension. Our study was designed to determine the effects of combined ni", "tokenized_content": [2, 16453, 3, 5891, 23682, 1922, 1920, 6567, 2007, 4820, 1988, 5267, 8686, 14966, 1921, 17, 2719, 16453, 18, 2342, 2161, 1982, 4609, 1942, 3415, 1920, 2564, 1927, 4252, 7781, 3]}, "items": [{"id": "p_4565", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4566", "content": "phenylephrine [SEP] designed to determine the effects of combined nitroglycerin and phenylephrine therapy. Ten patients with acute transmural myocardial infarcti", "tokenized_content": [2, 27053, 3, 4609, 1942, 3415, 1920, 2564, 1927, 4252, 8686, 14966, 1921, 1930, 27053, 3181, 18, 5656, 2132, 1956, 3939, 30306, 6497, 13389, 1033, 3]}, "items": [{"id": "p_4566", "content": "Phenylephrine [SEP] An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27053, 3, 1925, 4595, 17, 21, 13672, 7829, 2251, 1966, 43, 15388, 3027, 2479, 16, 9305, 2344, 18771, 2156, 2031, 16, 1930, 21129, 24970, 5899, 18, 3]}]}
{"query": {"id": "q_4567", "content": "myocardial infarctions [SEP] n and phenylephrine therapy. Ten patients with acute transmural myocardial infarctions received intravenous nitroglycerin, sufficient to reduce mean a", "tokenized_content": [2, 6497, 8358, 1036, 3, 56, 1930, 27053, 3181, 18, 5656, 2132, 1956, 3939, 30306, 6497, 8358, 1036, 4004, 7307, 8686, 14966, 1921, 16, 5409, 1942, 4412, 2667, 43, 3]}, "items": [{"id": "p_4567", "content": "Myocardial Infarction [SEP] NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).\n    ", "score": 1, "type": null, "tokenized_content": [2, 6497, 8358, 3, 7476, 1927, 1920, 13295, 4189, 2007, 1925, 10849, 1927, 1920, 2877, 9042, 1942, 1920, 4003, 12, 5846, 9255, 13, 18, 3]}]}
{"query": {"id": "q_4568", "content": "CaCl2 [SEP] 17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model.", "tokenized_content": [2, 13809, 3, 2752, 16, 6736, 17, 22, 1930, 6736, 17, 29, 2294, 1956, 4996, 9174, 4075, 13809, 17, 2719, 10670, 7677, 13373, 1922, 43, 3067, 2322, 18, 3]}, "items": [{"id": "p_4568", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_4569", "content": "thoracic aortic aneurysm [SEP] MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model.", "tokenized_content": [2, 10670, 7677, 13373, 3, 6736, 17, 29, 2294, 1956, 4996, 9174, 4075, 13809, 17, 2719, 10670, 7677, 13373, 1922, 43, 3067, 2322, 18, 3]}, "items": [{"id": "p_4569", "content": "Aortic Aneurysm, Thoracic [SEP] An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives r", "score": 1, "type": null, "tokenized_content": [2, 7677, 13373, 16, 10670, 3, 1925, 4552, 13819, 17, 2014, 10791, 17, 3189, 17799, 1922, 1920, 4821, 1927, 1920, 10670, 11859, 18, 2052, 6863, 14931, 7717, 1927, 11859, 10006, 60, 3]}]}
{"query": {"id": "q_4570", "content": "thoracic aortic aneurysm [SEP] PURPOSE: This study was designed to establish a rat model of thoracic aortic aneurysm (TAA) by calcium chloride (CaCl(2))-induced arterial injury and", "tokenized_content": [2, 10670, 7677, 13373, 3, 5120, 30, 2052, 2161, 1982, 4609, 1942, 5389, 43, 3067, 2322, 1927, 10670, 7677, 13373, 12, 23650, 13, 2007, 5016, 9140, 12, 9703, 1024, 12, 22, 3]}, "items": [{"id": "p_4570", "content": "Aortic Aneurysm, Thoracic [SEP] An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives r", "score": 1, "type": null, "tokenized_content": [2, 7677, 13373, 16, 10670, 3, 1925, 4552, 13819, 17, 2014, 10791, 17, 3189, 17799, 1922, 1920, 4821, 1927, 1920, 10670, 11859, 18, 2052, 6863, 14931, 7717, 1927, 11859, 10006, 60, 3]}]}
{"query": {"id": "q_4571", "content": "TAA [SEP]  designed to establish a rat model of thoracic aortic aneurysm (TAA) by calcium chloride (CaCl(2))-induced arterial injury and to e", "tokenized_content": [2, 23650, 3, 4609, 1942, 5389, 43, 3067, 2322, 1927, 10670, 7677, 13373, 12, 23650, 13, 2007, 5016, 9140, 12, 9703, 1024, 12, 22, 13, 13, 17, 2719, 6624, 4047, 1930, 3]}, "items": [{"id": "p_4571", "content": "Aortic Aneurysm, Thoracic [SEP] An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives r", "score": 1, "type": null, "tokenized_content": [2, 7677, 13373, 16, 10670, 3, 1925, 4552, 13819, 17, 2014, 10791, 17, 3189, 17799, 1922, 1920, 4821, 1927, 1920, 10670, 11859, 18, 2052, 6863, 14931, 7717, 1927, 11859, 10006, 60, 3]}]}
{"query": {"id": "q_4572", "content": "calcium chloride [SEP] d to establish a rat model of thoracic aortic aneurysm (TAA) by calcium chloride (CaCl(2))-induced arterial injury and to explore the potential ", "tokenized_content": [2, 5016, 9140, 3, 46, 1942, 5389, 43, 3067, 2322, 1927, 10670, 7677, 13373, 12, 23650, 13, 2007, 5016, 9140, 12, 9703, 1024, 12, 22, 13, 13, 17, 2719, 6624, 4047, 3]}, "items": [{"id": "p_4572", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_4573", "content": "CaCl(2) [SEP] at model of thoracic aortic aneurysm (TAA) by calcium chloride (CaCl(2))-induced arterial injury and to explore the potential role of a", "tokenized_content": [2, 9703, 1024, 12, 22, 13, 3, 2019, 2322, 1927, 10670, 7677, 13373, 12, 23650, 13, 2007, 5016, 9140, 12, 9703, 1024, 12, 22, 13, 13, 17, 2719, 6624, 4047, 1930, 3]}, "items": [{"id": "p_4573", "content": "Calcium Chloride [SEP] A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5016, 9140, 3, 43, 7012, 2251, 1942, 24549, 2471, 5016, 2428, 16, 1966, 1925, 2687, 17, 7144, 26829, 16, 1930, 1966, 1925, 30483, 7229, 1958, 13148, 18722, 18, 3]}]}
{"query": {"id": "q_4574", "content": "arterial injury [SEP] cic aortic aneurysm (TAA) by calcium chloride (CaCl(2))-induced arterial injury and to explore the potential role of a disintegrin and metallop", "tokenized_content": [2, 6624, 4047, 3, 18840, 7677, 13373, 12, 23650, 13, 2007, 5016, 9140, 12, 9703, 1024, 12, 22, 13, 13, 17, 2719, 6624, 4047, 1930, 1942, 6414, 1920, 2889, 2770, 1927, 3]}, "items": [{"id": "p_4574", "content": "Vascular Diseases [SEP] Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ART", "score": 1, "type": null, "tokenized_content": [2, 4541, 3902, 3, 6598, 4028, 5884, 2967, 1927, 1920, 2877, 7208, 1922, 1920, 4435, 2014, 5009, 9255, 18, 2611, 3951, 3902, 1927, 6903, 3]}]}
{"query": {"id": "q_4575", "content": "NaCl [SEP] rague-Dawley rats was exposed to 0.5M CaCl(2) or normal saline (NaCl). After 12weeks, animals were euthanized, and CaCl(2)-treated, ", "tokenized_content": [2, 6392, 3, 13745, 2182, 17, 15798, 3615, 1982, 4616, 1942, 20, 18, 25, 1035, 9703, 1024, 12, 22, 13, 2014, 2791, 5977, 12, 6392, 13, 18, 2256, 2369, 2172, 2819, 3]}, "items": [{"id": "p_4575", "content": "Sodium Chloride [SEP] A ubiquitous sodium salt that is commonly used to season food.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 9140, 3, 43, 15498, 5227, 7012, 1988, 1977, 5384, 2251, 1942, 9520, 3959, 18, 3]}]}
{"query": {"id": "q_4576", "content": "right heart failure [SEP] three hours after heart transplantation, life-threatening acute right heart failure was diagnosed in a patient requiring continuous venovenous hemo", "tokenized_content": [2, 3659, 4003, 4574, 3, 2559, 3967, 2256, 4003, 6530, 16, 3308, 17, 13281, 3939, 3659, 4003, 4574, 1982, 5377, 1922, 43, 2774, 8887, 4798, 8102, 24831, 3243, 1037, 3]}, "items": [{"id": "p_4576", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4577", "content": "catecholamines [SEP] uous venovenous hemodiafiltration (CVVHDF). Increasing doses of catecholamines, sedatives, and muscle relaxants administered through a central", "tokenized_content": [2, 25923, 3, 63, 2080, 8102, 24831, 3243, 13968, 6870, 6003, 12, 5519, 27211, 1038, 13, 18, 3605, 5312, 1927, 25923, 16, 28514, 1036, 16, 1930, 3760, 7327, 2356, 5254, 2596, 3]}, "items": [{"id": "p_4577", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_4578", "content": "epinephrine [SEP] a central venous catheter were ineffective. However, a bolus of epinephrine injected through an alternative catheter provoked a hypertensiv", "tokenized_content": [2, 19280, 3, 43, 4101, 8562, 8421, 1985, 15302, 18, 2406, 16, 43, 14840, 1927, 19280, 5624, 2596, 1925, 5012, 8421, 27116, 43, 4506, 2099, 2068, 3]}, "items": [{"id": "p_4578", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_4579", "content": "hypertensive [SEP] epinephrine injected through an alternative catheter provoked a hypertensive crisis. Thus, interference with the central venous infusion by ", "tokenized_content": [2, 11706, 3, 19280, 5624, 2596, 1925, 5012, 8421, 27116, 43, 11706, 17263, 18, 2842, 16, 8703, 1956, 1920, 4101, 8562, 7386, 2007, 3]}, "items": [{"id": "p_4579", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4580", "content": "catecholamine [SEP] uous venovenous hemodiafiltration (CVVHDF). Increasing doses of catecholamines, sedatives, and muscle relaxants administered through a centra", "tokenized_content": [2, 23483, 3, 63, 2080, 8102, 24831, 3243, 13968, 6870, 6003, 12, 5519, 27211, 1038, 13, 18, 3605, 5312, 1927, 25923, 16, 28514, 1036, 16, 1930, 3760, 7327, 2356, 5254, 2596, 3]}, "items": [{"id": "p_4580", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_4581", "content": "glutamate [SEP] Long-term glutamate supplementation failed to protect against peripheral neurotoxic", "tokenized_content": [2, 7627, 3, 2815, 17, 2576, 7627, 8746, 6617, 1942, 9145, 3316, 5009, 20919, 3]}, "items": [{"id": "p_4581", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_4582", "content": "peripheral neurotoxicity [SEP] Long-term glutamate supplementation failed to protect against peripheral neurotoxicity of paclitaxel.", "tokenized_content": [2, 5009, 18034, 3, 2815, 17, 2576, 7627, 8746, 6617, 1942, 9145, 3316, 5009, 18034, 1927, 12404, 18, 3]}, "items": [{"id": "p_4582", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_4583", "content": "paclitaxel [SEP] mentation failed to protect against peripheral neurotoxicity of paclitaxel.", "tokenized_content": [2, 12404, 3, 11567, 1943, 6617, 1942, 9145, 3316, 5009, 18034, 1927, 12404, 18, 3]}, "items": [{"id": "p_4583", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_4584", "content": "peripheral neuropathy [SEP] Toxic peripheral neuropathy is still a significant limiting factor for chemotherapy with pa", "tokenized_content": [2, 5009, 13177, 3, 6161, 5009, 13177, 1977, 3974, 43, 2228, 8051, 2991, 1958, 5318, 1956, 3838, 3]}, "items": [{"id": "p_4584", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_4585", "content": "paclitaxel [SEP] hy is still a significant limiting factor for chemotherapy with paclitaxel (PAC), although glutamate and its closely related amino acid gl", "tokenized_content": [2, 12404, 3, 4527, 1977, 3974, 43, 2228, 8051, 2991, 1958, 5318, 1956, 12404, 12, 6866, 13, 16, 2876, 7627, 1930, 2496, 6538, 2712, 3835, 2687, 2393, 3]}, "items": [{"id": "p_4585", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_4586", "content": "PAC [SEP] a significant limiting factor for chemotherapy with paclitaxel (PAC), although glutamate and its closely related amino acid glutami", "tokenized_content": [2, 6866, 3, 43, 2228, 8051, 2991, 1958, 5318, 1956, 12404, 12, 6866, 13, 16, 2876, 7627, 1930, 2496, 6538, 2712, 3835, 2687, 6298, 1033, 3]}, "items": [{"id": "p_4586", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_4587", "content": "glutamate [SEP] imiting factor for chemotherapy with paclitaxel (PAC), although glutamate and its closely related amino acid glutamine were claimed to am", "tokenized_content": [2, 7627, 3, 2042, 3658, 2991, 1958, 5318, 1956, 12404, 12, 6866, 13, 16, 2876, 7627, 1930, 2496, 6538, 2712, 3835, 2687, 9959, 1985, 21450, 1942, 2150, 3]}, "items": [{"id": "p_4587", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_4588", "content": "amino acid [SEP] th paclitaxel (PAC), although glutamate and its closely related amino acid glutamine were claimed to ameliorate PAC neurotoxicity. This pi", "tokenized_content": [2, 3835, 2687, 3, 1913, 12404, 12, 6866, 13, 16, 2876, 7627, 1930, 2496, 6538, 2712, 3835, 2687, 9959, 1985, 21450, 1942, 20611, 6866, 18034, 18, 2052, 4269, 3]}, "items": [{"id": "p_4588", "content": "Amino Acids [SEP] Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits", "score": 1, "type": null, "tokenized_content": [2, 3835, 4576, 3, 6805, 4300, 1988, 4933, 5531, 1925, 3835, 12, 17, 15410, 13, 1930, 43, 9943, 12, 17, 20729, 13, 2210, 18, 7639, 4595, 17, 3835, 4576, 2032, 1920, 6991, 3]}]}
{"query": {"id": "q_4589", "content": "glutamine [SEP] el (PAC), although glutamate and its closely related amino acid glutamine were claimed to ameliorate PAC neurotoxicity. This pilot trial ", "tokenized_content": [2, 9959, 3, 2349, 12, 6866, 13, 16, 2876, 7627, 1930, 2496, 6538, 2712, 3835, 2687, 9959, 1985, 21450, 1942, 20611, 6866, 18034, 18, 2052, 9404, 3046, 3]}, "items": [{"id": "p_4589", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_4590", "content": "neurotoxicity [SEP] ely related amino acid glutamine were claimed to ameliorate PAC neurotoxicity. This pilot trial aimed to evaluate the role of glutamate suppl", "tokenized_content": [2, 18034, 3, 2349, 1012, 2712, 3835, 2687, 9959, 1985, 21450, 1942, 20611, 6866, 18034, 18, 2052, 9404, 3046, 6822, 1942, 4323, 1920, 2770, 1927, 7627, 12227, 3]}, "items": [{"id": "p_4590", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4591", "content": "ovarian cancer [SEP] uble-blinded clinical and electro-diagnostic study. Forty-three ovarian cancer patients were available for analysis following six cycles of th", "tokenized_content": [2, 6751, 2539, 3, 4803, 1952, 17, 11620, 2535, 1930, 4260, 17, 4785, 2161, 18, 11270, 17, 2559, 6751, 2539, 2132, 1985, 3322, 1958, 2333, 2894, 3798, 6355, 1927, 1913, 3]}, "items": [{"id": "p_4591", "content": "Ovarian Neoplasms [SEP] Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin", "score": 1, "type": null, "tokenized_content": [2, 6751, 15347, 3, 3861, 2014, 2539, 1927, 1920, 13464, 18, 2144, 15347, 2112, 1998, 8867, 2014, 6558, 18, 2611, 2032, 5947, 3147, 1942, 1920, 2960, 1927, 4853, 3]}]}
{"query": {"id": "q_4592", "content": "pain [SEP] e reached statistical significance only with regard to reported pain sensation (P = 0.011). Also the frequency of abnormal electro-d", "tokenized_content": [2, 3594, 3, 47, 6690, 3850, 4550, 2444, 1956, 4623, 1942, 2568, 3594, 15826, 12, 58, 33, 20, 18, 15587, 13, 18, 2222, 1920, 3528, 1927, 4552, 4260, 17, 46, 3]}, "items": [{"id": "p_4592", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4593", "content": "peripheral neurotoxicity [SEP]  supplementation at the chosen regimen fails to protect against peripheral neurotoxicity of PAC.", "tokenized_content": [2, 5009, 18034, 3, 8746, 2019, 1920, 6724, 8607, 16300, 1942, 9145, 3316, 5009, 18034, 1927, 6866, 18, 3]}, "items": [{"id": "p_4593", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_4594", "content": "pain [SEP] Attentional modulation of perceived pain intensity in capsaicin-induced secondary hyperalgesia.", "tokenized_content": [2, 3594, 3, 13689, 7145, 1927, 6523, 3594, 4266, 1922, 19156, 17, 2719, 4067, 21525, 18, 3]}, "items": [{"id": "p_4594", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4595", "content": "capsaicin [SEP] Attentional modulation of perceived pain intensity in capsaicin-induced secondary hyperalgesia.", "tokenized_content": [2, 19156, 3, 13689, 7145, 1927, 6523, 3594, 4266, 1922, 19156, 17, 2719, 4067, 21525, 18, 3]}, "items": [{"id": "p_4595", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_4596", "content": "hyperalgesia [SEP] tion of perceived pain intensity in capsaicin-induced secondary hyperalgesia.", "tokenized_content": [2, 21525, 3, 8685, 1916, 1927, 6523, 3594, 4266, 1922, 19156, 17, 2719, 4067, 21525, 18, 3]}, "items": [{"id": "p_4596", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4597", "content": "pain [SEP] Perceived pain intensity is modulated by attention. However, it is not known t", "tokenized_content": [2, 3594, 3, 6523, 3594, 4266, 1977, 9985, 2007, 4976, 18, 2406, 16, 2176, 1977, 2084, 3171, 62, 3]}, "items": [{"id": "p_4597", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4598", "content": "capsaicin [SEP] wn that how pain intensity ratings are affected by attention in capsaicin-induced secondary hyperalgesia. Here we show that perceived pai", "tokenized_content": [2, 19156, 3, 14191, 1988, 2307, 3594, 4266, 10158, 2032, 4218, 2007, 4976, 1922, 19156, 17, 2719, 4067, 21525, 18, 3410, 2038, 2146, 1988, 6523, 15885, 3]}, "items": [{"id": "p_4598", "content": "Capsaicin [SEP] An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19156, 3, 1925, 13345, 5482, 2435, 1922, 7070, 27999, 1988, 8016, 2019, 23067, 9976, 5628, 18, 3]}]}
{"query": {"id": "q_4599", "content": "hyperalgesia [SEP] atings are affected by attention in capsaicin-induced secondary hyperalgesia. Here we show that perceived pain intensity in secondary hypera", "tokenized_content": [2, 21525, 3, 2019, 4689, 2032, 4218, 2007, 4976, 1922, 19156, 17, 2719, 4067, 21525, 18, 3410, 2038, 2146, 1988, 6523, 3594, 4266, 1922, 4067, 4194, 1019, 3]}, "items": [{"id": "p_4599", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4600", "content": "Testosterone [SEP] Testosterone-dependent hypertension and upregulation of intrarenal angiotens", "tokenized_content": [2, 10592, 3, 10592, 17, 3100, 5579, 1930, 8346, 1927, 5153, 2825, 1923, 10747, 2099, 3]}, "items": [{"id": "p_4600", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_4601", "content": "hypertension [SEP] Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sen", "tokenized_content": [2, 5579, 3, 10592, 17, 3100, 5579, 1930, 8346, 1927, 5153, 2825, 1923, 10814, 2404, 1922, 3692, 7806, 7012, 17, 6964, 3]}, "items": [{"id": "p_4601", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4602", "content": "salt [SEP] rtension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats.", "tokenized_content": [2, 7012, 3, 4341, 3212, 1930, 8346, 1927, 5153, 2825, 1923, 10814, 2404, 1922, 3692, 7806, 7012, 17, 4532, 3615, 18, 3]}, "items": [{"id": "p_4602", "content": "Sodium Chloride, Dietary [SEP] Sodium chloride used in foods.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 9140, 16, 6096, 3, 5227, 9140, 2251, 1922, 9660, 18, 3]}]}
{"query": {"id": "q_4603", "content": "salt [SEP] Blood pressure (BP) is more salt sensitive in men than in premenopausal women. In Dahl salt-sens", "tokenized_content": [2, 7012, 3, 2877, 3772, 12, 4149, 13, 1977, 2253, 7012, 4532, 1922, 3925, 2254, 1922, 23693, 3089, 18, 1922, 3692, 7806, 7012, 17, 2658, 3]}, "items": [{"id": "p_4603", "content": "Sodium Chloride, Dietary [SEP] Sodium chloride used in foods.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5227, 9140, 16, 6096, 3, 5227, 9140, 2251, 1922, 9660, 18, 3]}]}
{"query": {"id": "q_4604", "content": "angiotensin [SEP] P more in males than females. In contrast to the systemic renin-angiotensin system, which is suppressed in response to HS in male DS, intra", "tokenized_content": [2, 10814, 3, 58, 2253, 1922, 5129, 2254, 5027, 18, 1922, 3320, 1942, 1920, 5510, 16306, 17, 10814, 2433, 16, 2154, 1977, 7657, 1922, 2644, 1942, 4193, 1922, 4005, 4473, 16, 3]}, "items": [{"id": "p_4604", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_4605", "content": "testosterone [SEP] -induced upregulation of intrarenal angiotensinogen mediated by testosterone that also causes increases in BP and renal injury. On a low-sal", "tokenized_content": [2, 10592, 3, 17, 2719, 8346, 1927, 5153, 2825, 1923, 10814, 2404, 3434, 2007, 10592, 1988, 2222, 5092, 4041, 1922, 4149, 1930, 4604, 4047, 18, 1990, 43, 2330, 17, 3370, 3]}, "items": [{"id": "p_4605", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_4606", "content": "renal injury [SEP] n mediated by testosterone that also causes increases in BP and renal injury. On a low-salt (LS) diet, male DS had higher levels of intraren", "tokenized_content": [2, 4604, 4047, 3, 56, 3434, 2007, 10592, 1988, 2222, 5092, 4041, 1922, 4149, 1930, 4604, 4047, 18, 1990, 43, 2330, 17, 7012, 12, 6639, 13, 3986, 16, 4005, 4473, 2430, 3]}, "items": [{"id": "p_4606", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4607", "content": "glomerular sclerosis [SEP]  progressive increase in BP, protein and albumin excretion, and glomerular sclerosis in male DS rats, which were attenuated by castration. Testoster", "tokenized_content": [2, 11655, 11484, 3, 7529, 2760, 1922, 4149, 16, 2213, 1930, 7712, 11093, 16, 1930, 11655, 11484, 1922, 4005, 4473, 3615, 16, 2154, 1985, 8060, 2007, 24458, 18, 2648, 5171, 3]}, "items": [{"id": "p_4607", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4608", "content": "Testosterone [SEP] sclerosis in male DS rats, which were attenuated by castration. Testosterone replacement in castrated DS rats increased BP, renal injury, an", "tokenized_content": [2, 10592, 3, 11484, 1922, 4005, 4473, 3615, 16, 2154, 1985, 8060, 2007, 24458, 18, 10592, 7619, 1922, 12273, 5524, 2013, 4473, 3615, 2502, 4149, 16, 4604, 4047, 16, 1925, 3]}, "items": [{"id": "p_4608", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_4609", "content": "hypertension [SEP] ed with HS diet. Testosterone contributes to the development of hypertension and renal injury in male DS rats on HS diet possibly through up", "tokenized_content": [2, 5579, 3, 3347, 1956, 4193, 3986, 18, 10592, 7624, 1942, 1920, 2740, 1927, 5579, 1930, 4604, 4047, 1922, 4005, 4473, 3615, 1990, 4193, 3986, 6553, 2596, 2353, 3]}, "items": [{"id": "p_4609", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4610", "content": "dopamine [SEP] Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor ", "tokenized_content": [2, 7964, 3, 10907, 2213, 10837, 13714, 7964, 17, 3434, 5888, 1930, 12214, 1930, 16922, 3148, 3]}, "items": [{"id": "p_4610", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4611", "content": "schizophrenia [SEP]  that prenatal nutritional deprivation may increase the risk of schizophrenia. The goal of these studies was to use an animal model to examin", "tokenized_content": [2, 7899, 3, 1988, 10907, 9369, 10837, 2278, 2760, 1920, 2565, 1927, 7899, 18, 1920, 6640, 1927, 2144, 2351, 1982, 1942, 2485, 1925, 4027, 2322, 1942, 2493, 1921, 3]}, "items": [{"id": "p_4611", "content": "Schizophrenia [SEP] A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALL", "score": 1, "type": null, "tokenized_content": [2, 7899, 3, 43, 4010, 6687, 4770, 1927, 16651, 6070, 6293, 2169, 4961, 2007, 43, 6415, 5376, 1031, 2037, 15928, 1956, 2723, 2670, 3337, 16, 9004, 3]}]}
{"query": {"id": "q_4612", "content": "apomorphine [SEP] ed (PD) female rats showed an increased stereotypic response to apomorphine and an increased locomotor response to amphetamine in adulthood", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 3347, 12, 3203, 13, 4232, 3615, 2594, 1925, 2502, 18028, 2085, 1935, 2644, 1942, 11466, 12492, 11119, 7969, 2912, 1930, 1925, 2502, 13594, 2644, 3]}, "items": [{"id": "p_4612", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_4613", "content": "amphetamine [SEP]  response to apomorphine and an increased locomotor response to amphetamine in adulthood. These differences were not observed during pubert", "tokenized_content": [2, 19057, 3, 2644, 1942, 11466, 12492, 11119, 7969, 2912, 1930, 1925, 2502, 13594, 2644, 1942, 19057, 1922, 10731, 18, 2144, 2886, 1985, 2084, 2528, 2409, 3080, 3062, 3]}, "items": [{"id": "p_4613", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_4614", "content": "haloperidol [SEP] ese differences were not observed during puberty. No changes in haloperidol-induced catalepsy or MK-801-induced locomotion were seen follow", "tokenized_content": [2, 25107, 3, 2376, 1021, 2886, 1985, 2084, 2528, 2409, 18335, 18, 2239, 2840, 1922, 25107, 17, 2719, 4233, 9431, 1012, 2014, 10539, 17, 23858, 17, 2719, 16929, 1985, 3945, 2396, 3]}, "items": [{"id": "p_4614", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_4615", "content": "catalepsy [SEP]  not observed during puberty. No changes in haloperidol-induced catalepsy or MK-801-induced locomotion were seen following PD. In additio", "tokenized_content": [2, 4233, 9431, 1012, 3, 2084, 2528, 2409, 18335, 18, 2239, 2840, 1922, 25107, 17, 2719, 4233, 9431, 1012, 2014, 10539, 17, 23858, 17, 2719, 16929, 1985, 3945, 2894, 3203, 18, 3]}, "items": [{"id": "p_4615", "content": "Catalepsy [SEP] A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. Th", "score": 1, "type": null, "tokenized_content": [2, 4233, 9431, 1012, 3, 43, 2625, 4378, 2007, 23144, 16, 3261, 10854, 1942, 5458, 16, 1930, 43, 10080, 1942, 6698, 1925, 26329, 1021, 17858, 18, 1913, 3]}]}
{"query": {"id": "q_4616", "content": "MK-801 [SEP]  during puberty. No changes in haloperidol-induced catalepsy or MK-801-induced locomotion were seen following PD. In addition, PD fema", "tokenized_content": [2, 10539, 17, 23858, 3, 2409, 18335, 18, 2239, 2840, 1922, 25107, 17, 2719, 4233, 9431, 1012, 2014, 10539, 17, 23858, 17, 2719, 16929, 1985, 3945, 2894, 3203, 18, 1922, 2459, 3]}, "items": [{"id": "p_4616", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_4617", "content": "H [SEP] n following PD. In addition, PD female rats showed increased (3)H-MK-801 binding in the striatum and hippocampus, but not in the ", "tokenized_content": [2, 50, 3, 56, 2894, 3203, 18, 1922, 2459, 16, 3203, 4232, 3615, 2594, 2502, 12, 23, 13, 50, 17, 10539, 17, 23858, 2743, 1922, 1920, 11259, 1930, 7661, 16, 2308, 3]}, "items": [{"id": "p_4617", "content": "Hydrogen [SEP] The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.008", "score": 1, "type": null, "tokenized_content": [2, 6201, 3, 1920, 2561, 4399, 6149, 1922, 1920, 12922, 2545, 18, 2176, 2258, 1920, 11241, 17530, 50, 16, 11241, 2529, 21, 16, 1930, 11241, 3388, 37, 21, 18, 13298, 11068, 31, 21, 18, 13587, 3]}]}
{"query": {"id": "q_4618", "content": "dopamine [SEP] ts also showed increased (3)H-haloperidol binding and decreased dopamine transporter binding in striatum. No statistically significant c", "tokenized_content": [2, 7964, 3, 4894, 2222, 2594, 2502, 12, 23, 13, 50, 17, 25107, 2743, 1930, 3261, 7964, 9054, 2743, 1922, 11259, 18, 2239, 4388, 2228, 45, 3]}, "items": [{"id": "p_4618", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4619", "content": "nutritional deficiency [SEP] model may be useful to explore the mechanisms by which prenatal nutritional deficiency enhances risk for schizophrenia in humans and may also have imp", "tokenized_content": [2, 9369, 6179, 3, 2322, 2278, 1998, 4707, 1942, 6414, 1920, 3531, 2007, 2154, 10907, 9369, 6179, 9515, 2565, 1958, 7899, 1922, 5209, 1930, 2278, 2222, 2162, 2754, 3]}, "items": [{"id": "p_4619", "content": "Malnutrition [SEP] An imbalanced nutritional status resulted from insufficient intake of nutrients to meet normal physiological requirement.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16823, 3, 1925, 14093, 1007, 9369, 3642, 4306, 2037, 9406, 5240, 1927, 11312, 1942, 9572, 2791, 5005, 8853, 18, 3]}]}
{"query": {"id": "q_4620", "content": "proteinuria [SEP] mToR inhibitors-induced proteinuria: mechanisms, significance, and management.", "tokenized_content": [2, 15831, 3, 7044, 4472, 17, 2719, 15831, 30, 3531, 16, 4550, 16, 1930, 4280, 18, 3]}, "items": [{"id": "p_4620", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_4621", "content": "rapamycin [SEP] r conversion from calcineurin inhibitors to mammalian target of rapamycin (mToR) inhibitors, especially sirolimus, in renal transplant re", "tokenized_content": [2, 11100, 3, 60, 7309, 2037, 19555, 4472, 1942, 6492, 2758, 1927, 11100, 12, 7044, 13, 4472, 16, 4369, 4520, 24124, 16, 1922, 4604, 5192, 1964, 3]}, "items": [{"id": "p_4621", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4622", "content": "sirolimus [SEP]  to mammalian target of rapamycin (mToR) inhibitors, especially sirolimus, in renal transplant recipients with chronic allograft nephropa", "tokenized_content": [2, 4520, 24124, 3, 1942, 6492, 2758, 1927, 11100, 12, 7044, 13, 4472, 16, 4369, 4520, 24124, 16, 1922, 4604, 5192, 9336, 1956, 3724, 15941, 7737, 2928, 1019, 3]}, "items": [{"id": "p_4622", "content": "Sirolimus [SEP] A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation o", "score": 1, "type": null, "tokenized_content": [2, 4520, 24124, 3, 43, 23929, 2261, 3547, 2926, 2037, 22874, 11654, 7771, 1957, 1988, 8016, 2007, 9331, 7472, 1920, 5224, 2936, 57, 3]}]}
{"query": {"id": "q_4623", "content": "chronic allograft nephropathy [SEP] tors, especially sirolimus, in renal transplant recipients with chronic allograft nephropathy. Because proteinuria is a major predictive factor of poor trans", "tokenized_content": [2, 3724, 15941, 15582, 3, 14823, 16, 4369, 4520, 24124, 16, 1922, 4604, 5192, 9336, 1956, 3724, 15941, 15582, 18, 2882, 15831, 1977, 43, 3044, 6207, 2991, 1927, 3930, 2127, 3]}, "items": [{"id": "p_4623", "content": "Renal Insufficiency, Chronic [SEP] Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is class", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 16, 3724, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1958, 2253, 2254, 2559, 3221, 18, 3724, 5245, 14566, 1977, 2921, 3]}]}
{"query": {"id": "q_4624", "content": "proteinuria [SEP] ansplant recipients with chronic allograft nephropathy. Because proteinuria is a major predictive factor of poor transplantation outcome, m", "tokenized_content": [2, 15831, 3, 18229, 4043, 9336, 1956, 3724, 15941, 15582, 18, 2882, 15831, 1977, 43, 3044, 6207, 2991, 1927, 3930, 6530, 3924, 16, 55, 3]}, "items": [{"id": "p_4624", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_4625", "content": "glomerulosclerosis [SEP] received sirolimus de novo. Podocyte injury and focal segmental glomerulosclerosis have been related to mToR inhibition in some patients, but the ", "tokenized_content": [2, 19268, 25081, 3, 4004, 4520, 24124, 2028, 9441, 18, 25123, 4047, 1930, 8083, 16294, 19268, 25081, 2162, 2252, 2712, 1942, 7044, 3523, 1922, 2673, 2132, 16, 2308, 1920, 3]}, "items": [{"id": "p_4625", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_4626", "content": "ribonucleic acid [SEP] Hypothalamic prolactin receptor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition ", "tokenized_content": [2, 18347, 1935, 2687, 3, 13654, 18386, 3148, 16716, 18347, 1935, 2687, 2428, 16, 18386, 3197, 16, 1930, 4194, 15743, 11686, 4197, 3523, 3]}, "items": [{"id": "p_4626", "content": "RNA [SEP] A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous b", "score": 1, "type": null, "tokenized_content": [2, 3146, 3, 43, 15176, 15274, 7600, 10163, 1927, 7835, 1956, 43, 21763, 10787, 1927, 5413, 1930, 17870, 5701, 1942, 2154, 6634, 2080, 44, 3]}]}
{"query": {"id": "q_4627", "content": "hyperprolactinemic [SEP] tor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are depen", "tokenized_content": [2, 4194, 15743, 11686, 4197, 3, 8184, 16716, 18347, 1935, 2687, 2428, 16, 18386, 3197, 16, 1930, 4194, 15743, 11686, 4197, 3523, 1927, 25960, 21600, 3903, 6365, 5512, 2032, 2554, 1917, 3]}, "items": [{"id": "p_4627", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_4628", "content": "estradiol [SEP] ion of pulsatile luteinizing hormone secretion are dependent on estradiol.", "tokenized_content": [2, 11513, 3, 4755, 1927, 25960, 21600, 3903, 6365, 5512, 2032, 3100, 1990, 11513, 18, 3]}, "items": [{"id": "p_4628", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_4629", "content": "Hyperprolactinemia [SEP] Hyperprolactinemia can reduce fertility and libido. Although central prolactin act", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 4194, 15743, 11686, 3847, 2112, 4412, 11869, 1930, 9954, 15072, 18, 2876, 4101, 18386, 4033, 3]}, "items": [{"id": "p_4629", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_4630", "content": "hyperprolactinemia [SEP] chanisms are poorly understood. We first tested whether chronic hyperprolactinemia inhibited two neuroendocrine parameters necessary for female fe", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2354, 5023, 2032, 7865, 7372, 18, 2038, 2561, 3620, 3053, 3724, 4194, 15743, 11686, 3847, 5069, 2288, 15980, 3673, 4680, 1958, 4232, 2650, 3]}, "items": [{"id": "p_4630", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_4631", "content": "estrogen [SEP]  necessary for female fertility: pulsatile LH secretion and the estrogen-induced LH surge. Chronic hyperprolactinemia induced by the dop", "tokenized_content": [2, 7940, 3, 4680, 1958, 4232, 11869, 30, 25960, 9107, 5512, 1930, 1920, 7940, 17, 2719, 9107, 8107, 18, 3724, 4194, 15743, 11686, 3847, 2719, 2007, 1920, 5190, 3]}, "items": [{"id": "p_4631", "content": "Estrogens [SEP] Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estr", "score": 1, "type": null, "tokenized_content": [2, 20470, 3, 4300, 1988, 6310, 1956, 7940, 4086, 1922, 2758, 3878, 1942, 12228, 3001, 1920, 2564, 2551, 1942, 2690, 1927, 11513, 18, 10105, 3]}]}
{"query": {"id": "q_4632", "content": "dopamine [SEP] gen-induced LH surge. Chronic hyperprolactinemia induced by the dopamine antagonist sulpiride caused a 40% reduction LH pulse frequency ", "tokenized_content": [2, 7964, 3, 2065, 17, 2719, 9107, 8107, 18, 3724, 4194, 15743, 11686, 3847, 2719, 2007, 1920, 7964, 8151, 9596, 10984, 20332, 1021, 4189, 43, 3040, 9, 3378, 9107, 7110, 3528, 3]}, "items": [{"id": "p_4632", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4633", "content": "sulpiride [SEP] . Chronic hyperprolactinemia induced by the dopamine antagonist sulpiride caused a 40% reduction LH pulse frequency in ovariectomized rat", "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 18, 3724, 4194, 15743, 11686, 3847, 2719, 2007, 1920, 7964, 8151, 9596, 10984, 20332, 1021, 4189, 43, 3040, 9, 3378, 9107, 7110, 3528, 1922, 26328, 3]}, "items": [{"id": "p_4633", "content": "Sulpiride [SEP] A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.", "score": 1, "type": null, "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 43, 7964, 8631, 17, 3148, 8151, 18, 2176, 2258, 2252, 2251, 25058, 1966, 1925, 14183, 16, 17581, 16, 1930, 1966, 43, 15486, 8379, 18, 3]}]}
{"query": {"id": "q_4634", "content": "estradiol [SEP] tomized rats, but only in the presence of chronic low levels of estradiol. Sulpiride did not affect the magnitude of a steroid-induced LH", "tokenized_content": [2, 11513, 3, 5970, 2301, 3615, 16, 2308, 2444, 1922, 1920, 2990, 1927, 3724, 2330, 2428, 1927, 11513, 18, 9596, 10984, 20332, 1021, 2811, 2084, 4081, 1920, 6453, 1927, 43, 9507, 3]}, "items": [{"id": "p_4634", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_4635", "content": "Sulpiride [SEP] s, but only in the presence of chronic low levels of estradiol. Sulpiride did not affect the magnitude of a steroid-induced LH surge or t", "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 61, 16, 2308, 2444, 1922, 1920, 2990, 1927, 3724, 2330, 2428, 1927, 11513, 18, 9596, 10984, 20332, 1021, 2811, 2084, 4081, 1920, 6453, 1927, 43, 3]}, "items": [{"id": "p_4635", "content": "Sulpiride [SEP] A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.", "score": 1, "type": null, "tokenized_content": [2, 9596, 10984, 20332, 1021, 3, 43, 7964, 8631, 17, 3148, 8151, 18, 2176, 2258, 2252, 2251, 25058, 1966, 1925, 14183, 16, 17581, 16, 1930, 1966, 43, 15486, 8379, 18, 3]}]}
{"query": {"id": "q_4636", "content": "steroid [SEP] evels of estradiol. Sulpiride did not affect the magnitude of a steroid-induced LH surge or the percentage of GnRH neurons activated du", "tokenized_content": [2, 9507, 3, 2180, 3222, 1927, 11513, 18, 9596, 10984, 20332, 1021, 2811, 2084, 4081, 1920, 6453, 1927, 43, 9507, 17, 2719, 9107, 8107, 2014, 1920, 4466, 1927, 13706, 3558, 4128, 3]}, "items": [{"id": "p_4636", "content": "Steroids [SEP] A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precurso", "score": 1, "type": null, "tokenized_content": [2, 13039, 3, 43, 2210, 1927, 12043, 13153, 4300, 6538, 2712, 25839, 1942, 6005, 17125, 1918, 18, 2611, 3951, 5463, 16, 6466, 10224, 16, 6380, 1037, 3]}]}
{"query": {"id": "q_4637", "content": "Estradiol [SEP] e or the percentage of GnRH neurons activated during the surge. Estradiol is known to influence expression of the long form of prolactin ", "tokenized_content": [2, 11513, 3, 47, 2014, 1920, 4466, 1927, 13706, 3558, 4128, 2409, 1920, 8107, 18, 11513, 1977, 3171, 1942, 4039, 2294, 1927, 1920, 2815, 2386, 1927, 18386, 3]}, "items": [{"id": "p_4637", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_4638", "content": "cholesteryl ester [SEP] Estrogen prevents cholesteryl ester accumulation in macrophages induced by the HIV protease inhibit", "tokenized_content": [2, 21211, 2734, 1024, 9603, 3, 7940, 10299, 21211, 2734, 1024, 9603, 4858, 1922, 5205, 2719, 2007, 1920, 3525, 7154, 2875, 3]}, "items": [{"id": "p_4638", "content": "Cholesterol Esters [SEP] Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholest", "score": 1, "type": null, "tokenized_content": [2, 5463, 16785, 3, 5934, 2687, 16785, 1927, 5463, 2154, 11480, 3001, 2288, 17, 16071, 1927, 1920, 5463, 1922, 1920, 3582, 18, 1920, 4858, 1927, 21211, 3]}]}
{"query": {"id": "q_4639", "content": "ritonavir [SEP] cumulation in macrophages induced by the HIV protease inhibitor ritonavir.", "tokenized_content": [2, 24019, 12502, 3026, 3, 7394, 2281, 1922, 5205, 2719, 2007, 1920, 3525, 7154, 4106, 24019, 12502, 3026, 18, 3]}, "items": [{"id": "p_4639", "content": "Ritonavir [SEP] An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.", "score": 1, "type": null, "tokenized_content": [2, 24019, 12502, 3026, 3, 1925, 3525, 7154, 4106, 1988, 10997, 2007, 13369, 1956, 1920, 7986, 4048, 1927, 3525, 18, 2176, 2222, 7042, 9387, 58, 17, 11193, 16066, 18, 3]}]}
{"query": {"id": "q_4640", "content": "ritonavir [SEP] th drug therapy that often includes protease inhibitors such as ritonavir. Many patients, however, develop negative long-term side effect", "tokenized_content": [2, 24019, 12502, 3026, 3, 1913, 2838, 3181, 1988, 3868, 5921, 7154, 4472, 2427, 1966, 24019, 12502, 3026, 18, 3086, 2132, 16, 2406, 16, 2392, 3136, 2815, 17, 2576, 4159, 2495, 3]}, "items": [{"id": "p_4640", "content": "Ritonavir [SEP] An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.", "score": 1, "type": null, "tokenized_content": [2, 24019, 12502, 3026, 3, 1925, 3525, 7154, 4106, 1988, 10997, 2007, 13369, 1956, 1920, 7986, 4048, 1927, 3525, 18, 2176, 2222, 7042, 9387, 58, 17, 11193, 16066, 18, 3]}]}
{"query": {"id": "q_4641", "content": "premature atherosclerosis [SEP] ients, however, develop negative long-term side effects such as premature atherosclerosis. We have previously demonstrated that ritonavir treatment incre", "tokenized_content": [2, 9839, 9824, 3, 10116, 4905, 1036, 16, 2406, 16, 2392, 3136, 2815, 17, 2576, 4159, 2564, 2427, 1966, 9839, 9824, 18, 2038, 2162, 3024, 3161, 1988, 24019, 12502, 3026, 2311, 3]}, "items": [{"id": "p_4641", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_4642", "content": "atherosclerotic lesion [SEP] have previously demonstrated that ritonavir treatment increases atherosclerotic lesion formation in male mice to a greater extent than in female mice.", "tokenized_content": [2, 13450, 5709, 3, 2162, 3024, 3161, 1988, 24019, 12502, 3026, 2311, 4041, 13450, 5709, 3337, 1922, 4005, 2518, 1942, 43, 3430, 5064, 2254, 1922, 4232, 2518, 18, 3]}, "items": [{"id": "p_4642", "content": "Atherosclerosis [SEP] A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the AR", "score": 1, "type": null, "tokenized_content": [2, 9824, 3, 43, 16121, 1930, 3257, 1927, 19680, 1927, 1920, 12430, 1927, 9345, 1988, 5110, 1956, 3337, 1927, 13450, 11694, 2651, 1920, 2245, 3]}]}
{"query": {"id": "q_4643", "content": "cholesteryl ester [SEP] lood monocytes isolated from ritonavir-treated females had less cholesteryl ester accumulation. In the present study, we have investigated the mo", "tokenized_content": [2, 21211, 2734, 1024, 9603, 3, 3004, 1986, 8713, 3937, 2037, 24019, 12502, 3026, 17, 2868, 5027, 2430, 2941, 21211, 2734, 1024, 9603, 4858, 18, 1922, 1920, 2481, 2161, 16, 2038, 3]}, "items": [{"id": "p_4643", "content": "Cholesterol Esters [SEP] Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholest", "score": 1, "type": null, "tokenized_content": [2, 5463, 16785, 3, 5934, 2687, 16785, 1927, 5463, 2154, 11480, 3001, 2288, 17, 16071, 1927, 1920, 5463, 1922, 1920, 3582, 18, 1920, 4858, 1927, 21211, 3]}]}
{"query": {"id": "q_4644", "content": "cholesterol [SEP] ted the molecular mechanisms by which female hormones influence cholesterol metabolism in macrophages in response to the HIV protease inhib", "tokenized_content": [2, 5463, 3, 26080, 1920, 3272, 3531, 2007, 2154, 4232, 10224, 4039, 5463, 4714, 1922, 5205, 1922, 2644, 1942, 1920, 3525, 7154, 2439, 3]}, "items": [{"id": "p_4644", "content": "Cholesterol [SEP] The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fat", "score": 1, "type": null, "tokenized_content": [2, 5463, 3, 1920, 7944, 20408, 1927, 2136, 2580, 3555, 16, 6533, 1922, 3362, 3878, 16, 4369, 1920, 3068, 1930, 6071, 6670, 16, 1930, 1922, 4027, 3777, 3]}]}
{"query": {"id": "q_4645", "content": "17beta-estradiol [SEP]  a macrophage-like phenotype in the presence or absence of 1 nM 17beta-estradiol (E2), 100 nM progesterone or vehicle (0.01% ethanol). Cells wer", "tokenized_content": [2, 2752, 20440, 17, 11513, 3, 43, 8088, 17, 3189, 4629, 1922, 1920, 2990, 2014, 3905, 1927, 21, 2943, 2752, 20440, 17, 11513, 12, 6602, 13, 16, 2813, 2943, 11528, 2014, 3]}, "items": [{"id": "p_4645", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_4646", "content": "E2 [SEP]  phenotype in the presence or absence of 1 nM 17beta-estradiol (E2), 100 nM progesterone or vehicle (0.01% ethanol). Cells were th", "tokenized_content": [2, 6602, 3, 4629, 1922, 1920, 2990, 2014, 3905, 1927, 21, 2943, 2752, 20440, 17, 11513, 12, 6602, 13, 16, 2813, 2943, 11528, 2014, 6463, 12, 20, 18, 3287, 9, 5757, 3]}, "items": [{"id": "p_4646", "content": "Estradiol [SEP] The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-bet", "score": 1, "type": null, "tokenized_content": [2, 11513, 3, 1920, 2752, 17, 4666, 17, 15348, 1927, 11513, 16, 1925, 8981, 18803, 12605, 9507, 1956, 9420, 2210, 2019, 23, 17, 4666, 17, 1930, 2752, 17, 4666, 17, 3507, 18, 11513, 17, 2752, 17, 2143, 3]}]}
{"query": {"id": "q_4647", "content": "progesterone [SEP] n the presence or absence of 1 nM 17beta-estradiol (E2), 100 nM progesterone or vehicle (0.01% ethanol). Cells were then treated with 30 ng/", "tokenized_content": [2, 11528, 3, 56, 1920, 2990, 2014, 3905, 1927, 21, 2943, 2752, 20440, 17, 11513, 12, 6602, 13, 16, 2813, 2943, 11528, 2014, 6463, 12, 20, 18, 3287, 9, 5757, 13, 3]}, "items": [{"id": "p_4647", "content": "Progesterone [SEP] The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTER", "score": 1, "type": null, "tokenized_content": [2, 11528, 3, 1920, 3044, 10759, 4926, 1923, 9507, 1988, 1977, 8366, 5985, 2007, 1920, 13776, 12867, 1989, 1930, 1920, 13752, 18, 11528, 8016, 1990, 1920, 8123, 3]}]}
{"query": {"id": "q_4648", "content": "ethanol [SEP] nM 17beta-estradiol (E2), 100 nM progesterone or vehicle (0.01% ethanol). Cells were then treated with 30 ng/ml ritonavir or vehicle in", "tokenized_content": [2, 5757, 3, 2943, 2752, 20440, 17, 11513, 12, 6602, 13, 16, 2813, 2943, 11528, 2014, 6463, 12, 20, 18, 3287, 9, 5757, 13, 18, 2094, 1985, 2759, 2868, 1956, 2627, 3]}, "items": [{"id": "p_4648", "content": "Ethanol [SEP] A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bacterici", "score": 1, "type": null, "tokenized_content": [2, 5757, 3, 43, 4021, 16, 29500, 5875, 6221, 14504, 2037, 1920, 8375, 6482, 1930, 6533, 5264, 1920, 3362, 18, 2176, 2258, 14027, 3349, 3]}]}
{"query": {"id": "q_4649", "content": "cholesteryl esters [SEP] pid or total RNA was isolated. E2 decreased the accumulation of cholesteryl esters in macrophages following ritonavir treatment. Ritonavir increas", "tokenized_content": [2, 21211, 2734, 1024, 16785, 3, 23234, 2014, 2698, 3146, 1982, 3937, 18, 6602, 3261, 1920, 4858, 1927, 21211, 2734, 1024, 16785, 1922, 5205, 2894, 24019, 12502, 3026, 2311, 18, 24019, 3]}, "items": [{"id": "p_4649", "content": "Cholesterol Esters [SEP] Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholest", "score": 1, "type": null, "tokenized_content": [2, 5463, 16785, 3, 5934, 2687, 16785, 1927, 5463, 2154, 11480, 3001, 2288, 17, 16071, 1927, 1920, 5463, 1922, 1920, 3582, 18, 1920, 4858, 1927, 21211, 3]}]}
{"query": {"id": "q_4650", "content": "Ritonavir [SEP] holesteryl esters in macrophages following ritonavir treatment. Ritonavir increased the expression of the scavenger receptor, CD36 mRNA, ", "tokenized_content": [2, 24019, 12502, 3026, 3, 17278, 1967, 2199, 16785, 1922, 5205, 2894, 24019, 12502, 3026, 2311, 18, 24019, 12502, 3026, 2502, 1920, 2294, 1927, 1920, 21433, 3148, 16, 21492, 3616, 16, 3]}, "items": [{"id": "p_4650", "content": "Ritonavir [SEP] An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.", "score": 1, "type": null, "tokenized_content": [2, 24019, 12502, 3026, 3, 1925, 3525, 7154, 4106, 1988, 10997, 2007, 13369, 1956, 1920, 7986, 4048, 1927, 3525, 18, 2176, 2222, 7042, 9387, 58, 17, 11193, 16066, 18, 3]}]}
{"query": {"id": "q_4651", "content": "seizure [SEP] ession of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal", "tokenized_content": [2, 11015, 3, 4023, 2001, 1927, 58, 17, 11424, 1922, 27997, 1028, 17, 5778, 2025, 12, 17, 13, 3615, 17602, 11015, 17, 2719, 2353, 17, 3640, 1927, 2052, 2838, 11247, 9054, 3]}, "items": [{"id": "p_4651", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4652", "content": "phenytoin [SEP] access of antiepileptic drugs (AEDs), we recently reported that phenytoin is a substrate for MRP2 in the BBB. However, one drawback of su", "tokenized_content": [2, 3037, 30177, 3, 4065, 1927, 29132, 4195, 12, 18572, 1036, 13, 16, 2038, 3998, 2568, 1988, 3037, 30177, 1977, 43, 4510, 1958, 27997, 1028, 1922, 1920, 12734, 18, 2406, 16, 3]}, "items": [{"id": "p_4652", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_4653", "content": "pilocarpine [SEP]  comparable overexpression of Pgp in the BBB was obtained after pilocarpine-induced seizures in wild-type Wistar rats. Experiments with sys", "tokenized_content": [2, 7547, 7095, 12184, 3, 5596, 5616, 1927, 22534, 1922, 1920, 12734, 1982, 2926, 2256, 7547, 7095, 12184, 17, 2719, 10060, 1922, 3576, 17, 2601, 15668, 3615, 18, 3144, 1956, 7930, 3]}, "items": [{"id": "p_4653", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_4654", "content": "seizures [SEP] ession of Pgp in the BBB was obtained after pilocarpine-induced seizures in wild-type Wistar rats. Experiments with systemic administrat", "tokenized_content": [2, 10060, 3, 4023, 2001, 1927, 22534, 1922, 1920, 12734, 1982, 2926, 2256, 7547, 7095, 12184, 17, 2719, 10060, 1922, 3576, 17, 2601, 15668, 3615, 18, 3144, 1956, 5510, 10473, 1926, 3]}, "items": [{"id": "p_4654", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4655", "content": "phenobarbital [SEP] . Experiments with systemic administration of the Pgp substrate phenobarbital and the selective Pgp inhibitor tariquidar in TR(-) rats substa", "tokenized_content": [2, 3037, 18986, 3, 18, 3144, 1956, 5510, 4183, 1927, 1920, 22534, 4510, 3037, 18986, 1930, 1920, 5328, 22534, 4106, 14517, 2850, 9532, 1005, 1922, 2025, 12, 17, 13, 3615, 5879, 3]}, "items": [{"id": "p_4655", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_4656", "content": "tariquidar [SEP] the Pgp substrate phenobarbital and the selective Pgp inhibitor tariquidar in TR(-) rats substantiated that Pgp is functional and compensa", "tokenized_content": [2, 14517, 2850, 9532, 1005, 3, 1920, 22534, 4510, 3037, 18986, 1930, 1920, 5328, 22534, 4106, 14517, 2850, 9532, 1005, 1922, 2025, 12, 17, 13, 3615, 21229, 2013, 1988, 22534, 1977, 3]}, "items": [{"id": "p_4656", "content": "tariquidar [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14517, 2850, 9532, 1005, 3, 3]}]}
{"query": {"id": "q_4657", "content": "injury to the brain [SEP] ause such a compensatory mechanism most likely occurs to reduce injury to the brain from cytotoxic compounds, the present data substantiate the con", "tokenized_content": [2, 4047, 1942, 1920, 3068, 3, 18238, 1021, 2427, 43, 13447, 2856, 2501, 3205, 5110, 1942, 4412, 4047, 1942, 1920, 3068, 2037, 8377, 4300, 16, 1920, 2481, 2230, 21229, 2057, 1920, 3]}, "items": [{"id": "p_4657", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_4658", "content": "seizure [SEP] Use of chromosome substitution strains to identify seizure susceptibility loci in mice.", "tokenized_content": [2, 11015, 3, 2485, 1927, 5597, 6636, 4046, 1942, 3512, 11015, 6461, 6971, 1922, 2518, 18, 3]}, "items": [{"id": "p_4658", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4659", "content": "Seizure [SEP] Seizure susceptibility varies among inbred mouse strains. Chromosome su", "tokenized_content": [2, 11015, 3, 11015, 6461, 10229, 2706, 19203, 3321, 4046, 18, 5597, 2020, 3]}, "items": [{"id": "p_4659", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4660", "content": "seizure [SEP] d to identify quantitative trait loci (QTLs) that contribute to seizure susceptibility. QTLs for susceptibility to pilocarpine-induced ", "tokenized_content": [2, 11015, 3, 46, 1942, 3512, 4794, 8823, 6971, 12, 20182, 13, 1988, 4672, 1942, 11015, 6461, 18, 20182, 1958, 6461, 1942, 7547, 7095, 12184, 17, 2719, 3]}, "items": [{"id": "p_4660", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4661", "content": "pilocarpine [SEP] ontribute to seizure susceptibility. QTLs for susceptibility to pilocarpine-induced seizures, a model of temporal lobe epilepsy, have not b", "tokenized_content": [2, 7547, 7095, 12184, 3, 9056, 3027, 16119, 1021, 1942, 11015, 6461, 18, 20182, 1958, 6461, 1942, 7547, 7095, 12184, 17, 2719, 10060, 16, 43, 2322, 1927, 5338, 9581, 9741, 16, 3]}, "items": [{"id": "p_4661", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_4662", "content": "seizures [SEP]  susceptibility. QTLs for susceptibility to pilocarpine-induced seizures, a model of temporal lobe epilepsy, have not been reported, and", "tokenized_content": [2, 10060, 3, 6461, 18, 20182, 1958, 6461, 1942, 7547, 7095, 12184, 17, 2719, 10060, 16, 43, 2322, 1927, 5338, 9581, 9741, 16, 2162, 2084, 2252, 2568, 16, 1930, 3]}, "items": [{"id": "p_4662", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4663", "content": "temporal lobe epilepsy [SEP]  for susceptibility to pilocarpine-induced seizures, a model of temporal lobe epilepsy, have not been reported, and CSS have not previously been used ", "tokenized_content": [2, 5338, 9581, 9741, 3, 1958, 6461, 1942, 7547, 7095, 12184, 17, 2719, 10060, 16, 43, 2322, 1927, 5338, 9581, 9741, 16, 2162, 2084, 2252, 2568, 16, 1930, 19908, 2162, 2084, 3]}, "items": [{"id": "p_4663", "content": "Epilepsy, Temporal Lobe [SEP] A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lob", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 5338, 9581, 3, 43, 5363, 17, 2712, 12, 8083, 13, 2386, 1927, 9741, 4378, 2007, 7457, 10060, 1988, 10149, 2037, 10334, 2651, 1920, 5338, 6948, 3]}]}
{"query": {"id": "q_4664", "content": "epilepsy [SEP] ation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine.", "tokenized_content": [2, 9741, 3, 2019, 2001, 1927, 4596, 5668, 1922, 1920, 3599, 2322, 1927, 9741, 2719, 2007, 7547, 7095, 12184, 18, 3]}, "items": [{"id": "p_4664", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_4665", "content": "pilocarpine [SEP] al involvement in the experimental model of epilepsy induced by pilocarpine.", "tokenized_content": [2, 7547, 7095, 12184, 3, 1969, 5668, 1922, 1920, 3599, 2322, 1927, 9741, 2719, 2007, 7547, 7095, 12184, 18, 3]}, "items": [{"id": "p_4665", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_4666", "content": "Mitochondrial abnormalities [SEP] Mitochondrial abnormalities have been associated with several aspects of epileptogenesis, s", "tokenized_content": [2, 4596, 6754, 3, 4596, 6754, 2162, 2252, 2458, 1956, 2980, 6082, 1927, 28367, 3761, 16, 61, 3]}, "items": [{"id": "p_4666", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_4667", "content": "death [SEP]  of epileptogenesis, such as energy generation, control of cell death, neurotransmitter synthesis, and free radical (FR) production. ", "tokenized_content": [2, 3539, 3, 1927, 28367, 3761, 16, 2427, 1966, 3844, 4841, 16, 2285, 1927, 2024, 3539, 16, 15223, 4271, 16, 1930, 3294, 6917, 12, 2415, 13, 3372, 18, 3]}, "items": [{"id": "p_4667", "content": "Death [SEP] Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular ", "score": 1, "type": null, "tokenized_content": [2, 3539, 3, 14104, 10975, 1927, 2136, 23792, 4088, 16, 16687, 2007, 3905, 1927, 6242, 11995, 1930, 2698, 3257, 1927, 5321, 3]}]}
{"query": {"id": "q_4668", "content": "status epilepticus [SEP] tudy, we investigated whether increased generation of FR during status epilepticus would be sufficient to provoke abnormalities in mtDNA and in th", "tokenized_content": [2, 3642, 16304, 1957, 3, 9037, 14458, 16, 2038, 3845, 3053, 2502, 4841, 1927, 2415, 2409, 3642, 16304, 1957, 2962, 1998, 5409, 1942, 2463, 12558, 6754, 1922, 11183, 1930, 1922, 1913, 3]}, "items": [{"id": "p_4668", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_4669", "content": "pilocarpine [SEP] omplex IV of the respiratory chain, in the chronic phase of the pilocarpine model of temporal lobe epilepsy. DNA analysis revealed low amou", "tokenized_content": [2, 7547, 7095, 12184, 3, 21921, 2592, 4370, 1927, 1920, 5481, 4659, 16, 1922, 1920, 3724, 3193, 1927, 1920, 7547, 7095, 12184, 2322, 1927, 5338, 9581, 9741, 18, 2678, 2333, 3404, 3]}, "items": [{"id": "p_4669", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_4670", "content": "temporal lobe epilepsy [SEP] iratory chain, in the chronic phase of the pilocarpine model of temporal lobe epilepsy. DNA analysis revealed low amounts of a 4.8 kb mtDNA deletion b", "tokenized_content": [2, 5338, 9581, 9741, 3, 3166, 2548, 4659, 16, 1922, 1920, 3724, 3193, 1927, 1920, 7547, 7095, 12184, 2322, 1927, 5338, 9581, 9741, 18, 2678, 2333, 3404, 2330, 6222, 1927, 43, 3]}, "items": [{"id": "p_4670", "content": "Epilepsy, Temporal Lobe [SEP] A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lob", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 5338, 9581, 3, 43, 5363, 17, 2712, 12, 8083, 13, 2386, 1927, 9741, 4378, 2007, 7457, 10060, 1988, 10149, 2037, 10334, 2651, 1920, 5338, 6948, 3]}]}
{"query": {"id": "q_4671", "content": "mitochondrial abnormalities [SEP] vity was observed through histochemistry. Although evidences of mitochondrial abnormalities were found in previously published studies, our results do not ", "tokenized_content": [2, 4596, 6754, 3, 5208, 1012, 1982, 2528, 2596, 2968, 7202, 18, 2876, 19827, 1927, 4596, 6754, 1985, 2435, 1922, 3024, 4586, 2351, 16, 2342, 2274, 2608, 2084, 3]}, "items": [{"id": "p_4671", "content": "Mitochondrial Diseases [SEP] Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondri", "score": 1, "type": null, "tokenized_content": [2, 4596, 3902, 3, 3902, 4189, 2007, 4552, 2347, 1927, 1920, 6489, 18, 2611, 2278, 1998, 4189, 2007, 3527, 16, 5815, 2014, 12911, 16, 1922, 3887, 1033, 3]}]}
{"query": {"id": "q_4672", "content": "thrombotic microangiopathy [SEP] Causes of acute thrombotic microangiopathy in patients receiving kidney transplantation.", "tokenized_content": [2, 21039, 2703, 9506, 6522, 3, 5092, 1927, 3939, 21039, 2703, 9506, 6522, 1922, 2132, 5962, 5245, 6530, 18, 3]}, "items": [{"id": "p_4672", "content": "Thrombotic Microangiopathies [SEP] Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC", "score": 1, "type": null, "tokenized_content": [2, 21039, 2703, 9506, 16038, 3, 3902, 1988, 3211, 1922, 11354, 1922, 14264, 27795, 18, 1920, 2288, 2501, 8753, 3902, 2032, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3]}]}
{"query": {"id": "q_4673", "content": "Thrombotic microangiopathy [SEP] OBJECTIVES: Thrombotic microangiopathy is a well-known problem in patients following renal transplanta", "tokenized_content": [2, 21039, 2703, 9506, 6522, 3, 7634, 30, 21039, 2703, 9506, 6522, 1977, 43, 2486, 17, 3171, 4915, 1922, 2132, 2894, 4604, 5192, 1019, 3]}, "items": [{"id": "p_4673", "content": "Thrombotic Microangiopathies [SEP] Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC", "score": 1, "type": null, "tokenized_content": [2, 21039, 2703, 9506, 16038, 3, 3902, 1988, 3211, 1922, 11354, 1922, 14264, 27795, 18, 1920, 2288, 2501, 8753, 3902, 2032, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3]}]}
{"query": {"id": "q_4674", "content": "thrombotic microangiopathy [SEP]  following renal transplantation. In postrenal transplantation, thrombotic microangiopathy is often a reflection of hemolytic uremic syndrome. We aimed to", "tokenized_content": [2, 21039, 2703, 9506, 6522, 3, 2894, 4604, 6530, 18, 1922, 2753, 2825, 1923, 6530, 16, 21039, 2703, 9506, 6522, 1977, 3868, 43, 13001, 1927, 21515, 29870, 4741, 18, 2038, 6822, 3]}, "items": [{"id": "p_4674", "content": "Thrombotic Microangiopathies [SEP] Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC", "score": 1, "type": null, "tokenized_content": [2, 21039, 2703, 9506, 16038, 3, 3902, 1988, 3211, 1922, 11354, 1922, 14264, 27795, 18, 1920, 2288, 2501, 8753, 3902, 2032, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3]}]}
{"query": {"id": "q_4675", "content": "hemolytic uremic syndrome [SEP] plantation, thrombotic microangiopathy is often a reflection of hemolytic uremic syndrome. We aimed to determine the causes of thrombotic microangiopathy", "tokenized_content": [2, 21515, 29870, 4741, 3, 4496, 1943, 16, 21039, 2703, 9506, 6522, 1977, 3868, 43, 13001, 1927, 21515, 29870, 4741, 18, 2038, 6822, 1942, 3415, 1920, 5092, 1927, 21039, 2703, 9506, 3]}, "items": [{"id": "p_4675", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_4676", "content": "cyclosporine [SEP]  were referred to us for follow-up. Three cases were related to cyclosporine, and 1 case was secondary to both cyclosporine and tacrolimus. ", "tokenized_content": [2, 21002, 3, 1985, 6656, 1942, 2022, 1958, 2396, 17, 2353, 18, 2559, 2919, 1985, 2712, 1942, 21002, 16, 1930, 21, 3087, 1982, 4067, 1942, 2321, 21002, 1930, 21801, 18, 3]}, "items": [{"id": "p_4676", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4677", "content": "tacrolimus [SEP] cyclosporine, and 1 case was secondary to both cyclosporine and tacrolimus. The fifth case had features of thrombotic microangiopathy rela", "tokenized_content": [2, 21801, 3, 21002, 16, 1930, 21, 3087, 1982, 4067, 1942, 2321, 21002, 1930, 21801, 18, 1920, 12052, 3087, 2430, 4075, 1927, 21039, 2703, 9506, 6522, 22247, 3]}, "items": [{"id": "p_4677", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4678", "content": "antiphospholipid syndrome [SEP] h case had features of thrombotic microangiopathy related to an antiphospholipid syndrome in a patient with systemic lupus erythematosus. CONCLUSIONS: In", "tokenized_content": [2, 2246, 7824, 16113, 4741, 3, 50, 3087, 2430, 4075, 1927, 21039, 2703, 9506, 6522, 2712, 1942, 1925, 2246, 7824, 16113, 4741, 1922, 43, 2774, 1956, 5510, 13711, 22045, 18, 4355, 3]}, "items": [{"id": "p_4678", "content": "Antiphospholipid Syndrome [SEP] The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a var", "score": 1, "type": null, "tokenized_content": [2, 2246, 7824, 16113, 4741, 3, 1920, 2990, 1927, 3788, 6554, 3316, 15619, 12, 3788, 16, 2246, 7824, 16113, 13, 18, 1920, 2625, 1977, 2458, 1956, 43, 4953, 3]}]}
{"query": {"id": "q_4679", "content": "systemic lupus erythematosus [SEP] pathy related to an antiphospholipid syndrome in a patient with systemic lupus erythematosus. CONCLUSIONS: In the literature, the most-frequent cause of hem", "tokenized_content": [2, 5510, 13711, 22045, 3, 2450, 1012, 2712, 1942, 1925, 2246, 7824, 16113, 4741, 1922, 43, 2774, 1956, 5510, 13711, 22045, 18, 4355, 30, 1922, 1920, 4431, 16, 1920, 2501, 17, 3]}, "items": [{"id": "p_4679", "content": "Lupus Erythematosus, Systemic [SEP] A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by ", "score": 1, "type": null, "tokenized_content": [2, 13711, 22045, 16, 5510, 3, 43, 3724, 16, 24683, 16, 3769, 16, 1930, 3868, 18850, 13564, 2405, 1935, 4770, 1927, 14948, 2960, 16, 4378, 22581, 2007, 3]}]}
{"query": {"id": "q_4680", "content": "toxicity [SEP] e. Other causes include drug-related (cyclosporine, tacrolimus) toxicity, procoagulant status, and antibody-mediated rejection. We found", "tokenized_content": [2, 5532, 3, 47, 18, 2303, 5092, 3951, 2838, 17, 2712, 12, 21002, 16, 21801, 13, 5532, 16, 9823, 6952, 11056, 17576, 1031, 3642, 16, 1930, 3533, 17, 3434, 10820, 18, 3]}, "items": [{"id": "p_4680", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4681", "content": "left ventricular systolic and diastolic dysfunction [SEP] Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose.", "tokenized_content": [2, 3506, 6493, 8541, 1930, 9395, 5273, 3, 4010, 10743, 3506, 6493, 8541, 1930, 9395, 5273, 2810, 1942, 24842, 26674, 19280, 21090, 18, 3]}, "items": [{"id": "p_4681", "content": "Ventricular Dysfunction, Left [SEP] A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; M", "score": 1, "type": null, "tokenized_content": [2, 6493, 5273, 16, 3506, 3, 43, 2625, 1922, 2154, 1920, 3506, 11887, 1927, 1920, 4003, 1982, 9346, 5761, 18, 2052, 2625, 5394, 5029, 1942, 4003, 4574, 31, 55, 3]}]}
{"query": {"id": "q_4682", "content": "epinephrine [SEP] systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose.", "tokenized_content": [2, 19280, 3, 8541, 1930, 9395, 5273, 2810, 1942, 24842, 26674, 19280, 21090, 18, 3]}, "items": [{"id": "p_4682", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_4683", "content": "overdose [SEP]  diastolic dysfunction due to accidental iatrogenic epinephrine overdose.", "tokenized_content": [2, 21090, 3, 9395, 5273, 2810, 1942, 24842, 26674, 19280, 21090, 18, 3]}, "items": [{"id": "p_4683", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4684", "content": "Catecholamine [SEP] Catecholamine-induced cardiomyopathy due to chronic excess of endogenous cate", "tokenized_content": [2, 23483, 3, 23483, 17, 2719, 14141, 2810, 1942, 3724, 5799, 1927, 5355, 3115, 1021, 3]}, "items": [{"id": "p_4684", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_4685", "content": "cardiomyopathy [SEP] Catecholamine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been rec", "tokenized_content": [2, 14141, 3, 23483, 17, 2719, 14141, 2810, 1942, 3724, 5799, 1927, 5355, 25923, 2258, 2252, 2090, 3]}, "items": [{"id": "p_4685", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_4686", "content": "catecholamines [SEP] mine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon. In co", "tokenized_content": [2, 25923, 3, 24165, 17, 2719, 14141, 2810, 1942, 3724, 5799, 1927, 5355, 25923, 2258, 2252, 6783, 1958, 8995, 1966, 43, 2535, 7902, 18, 1922, 2081, 3]}, "items": [{"id": "p_4686", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_4687", "content": "myocardial dysfunction [SEP] d for decades as a clinical phenomenon. In contrast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare. A 35-year-old woman ", "tokenized_content": [2, 6497, 5273, 3, 46, 1958, 8995, 1966, 43, 2535, 7902, 18, 1922, 3320, 16, 4710, 1927, 6497, 5273, 2810, 1942, 3939, 26674, 21090, 2032, 5844, 18, 43, 3259, 17, 2476, 3]}, "items": [{"id": "p_4687", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_4688", "content": "overdose [SEP] rast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare. A 35-year-old woman whose cervix uteri was inadverten", "tokenized_content": [2, 21090, 3, 6520, 1031, 16, 4710, 1927, 6497, 5273, 2810, 1942, 3939, 26674, 21090, 2032, 5844, 18, 43, 3259, 17, 2476, 17, 4156, 10440, 6098, 20453, 8123, 1033, 1982, 29574, 3]}, "items": [{"id": "p_4688", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4689", "content": "epinephrine [SEP] oman whose cervix uteri was inadvertently injected with 8 mg of epinephrine developed myocardial stunning that was characterized by severe ", "tokenized_content": [2, 19280, 3, 7254, 1928, 6098, 20453, 8123, 1033, 1982, 29574, 2512, 5624, 1956, 28, 2786, 1927, 19280, 3530, 6497, 1955, 13131, 1941, 1988, 1982, 4378, 2007, 4010, 3]}, "items": [{"id": "p_4689", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_4690", "content": "myocardial stunning [SEP] i was inadvertently injected with 8 mg of epinephrine developed myocardial stunning that was characterized by severe hemodynamic compromise, profou", "tokenized_content": [2, 6497, 1955, 13131, 1941, 3, 51, 1982, 29574, 2512, 5624, 1956, 28, 2786, 1927, 19280, 3530, 6497, 1955, 13131, 1941, 1988, 1982, 4378, 2007, 4010, 12173, 15386, 16, 3150, 4468, 3]}, "items": [{"id": "p_4690", "content": "Myocardial Stunning [SEP] Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity. I", "score": 1, "type": null, "tokenized_content": [2, 6497, 1955, 13131, 1941, 3, 7171, 5273, 1927, 1920, 13295, 2256, 43, 5310, 11631, 1927, 4010, 7716, 16, 1956, 13802, 7215, 1927, 13750, 2455, 18, 51, 3]}]}
{"query": {"id": "q_4691", "content": "left ventricular systolic and diastolic dysfunction [SEP] d by severe hemodynamic compromise, profound, albeit transient, left ventricular systolic and diastolic dysfunction, and only modestly elevated biochemical markers of myocardial n", "tokenized_content": [2, 3506, 6493, 8541, 1930, 9395, 5273, 3, 46, 2007, 4010, 12173, 15386, 16, 11098, 16, 12796, 6809, 16, 3506, 6493, 8541, 1930, 9395, 5273, 16, 1930, 2444, 21626, 4664, 6503, 3]}, "items": [{"id": "p_4691", "content": "Ventricular Dysfunction, Left [SEP] A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; M", "score": 1, "type": null, "tokenized_content": [2, 6493, 5273, 16, 3506, 3, 43, 2625, 1922, 2154, 1920, 3506, 11887, 1927, 1920, 4003, 1982, 9346, 5761, 18, 2052, 2625, 5394, 5029, 1942, 4003, 4574, 31, 55, 3]}]}
{"query": {"id": "q_4692", "content": "myocardial necrosis [SEP]  dysfunction, and only modestly elevated biochemical markers of myocardial necrosis. Our case illustrates the serious consequences of medical error", "tokenized_content": [2, 6497, 7476, 3, 5273, 16, 1930, 2444, 21626, 4664, 6503, 4432, 1927, 6497, 7476, 18, 2342, 3087, 11897, 1920, 7433, 7080, 1927, 3423, 4622, 3]}, "items": [{"id": "p_4692", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_4693", "content": "Urinary bladder cancer [SEP] Urinary bladder cancer in Wegener's granulomatosis: risks and relation to cyclophospha", "tokenized_content": [2, 7075, 7821, 2539, 3, 7075, 7821, 2539, 1922, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 30, 7481, 1930, 6147, 1942, 20585, 10647, 3508, 2722, 3]}, "items": [{"id": "p_4693", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_4694", "content": "Wegener's granulomatosis [SEP] Urinary bladder cancer in Wegener's granulomatosis: risks and relation to cyclophosphamide.", "tokenized_content": [2, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 3, 7075, 7821, 2539, 1922, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 30, 7481, 1930, 6147, 1942, 17135, 18, 3]}, "items": [{"id": "p_4694", "content": "Granulomatosis with Polyangiitis [SEP] A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) l", "score": 1, "type": null, "tokenized_content": [2, 25675, 4575, 8362, 1956, 4286, 9506, 3678, 3, 43, 13564, 2405, 1935, 2573, 1927, 43, 2796, 3299, 3872, 18, 2176, 1977, 4378, 2007, 4531, 1927, 1920, 2877, 7208, 12, 21548, 13, 54, 3]}]}
{"query": {"id": "q_4695", "content": "cyclophosphamide [SEP] adder cancer in Wegener's granulomatosis: risks and relation to cyclophosphamide.", "tokenized_content": [2, 17135, 3, 3019, 1915, 2539, 1922, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 30, 7481, 1930, 6147, 1942, 17135, 18, 3]}, "items": [{"id": "p_4695", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4696", "content": "bladder cancer [SEP] OBJECTIVE: To assess and characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener", "tokenized_content": [2, 7821, 2539, 3, 4470, 30, 1942, 2634, 1930, 30415, 1920, 2565, 1927, 7821, 2539, 16, 1930, 2496, 6147, 1942, 17135, 16, 1922, 2132, 1956, 2038, 14687, 1005, 3]}, "items": [{"id": "p_4696", "content": "Urinary Bladder Neoplasms [SEP] Tumors or cancer of the URINARY BLADDER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7075, 7821, 15347, 3, 3861, 2014, 2539, 1927, 1920, 7075, 7821, 18, 3]}]}
{"query": {"id": "q_4697", "content": "cyclophosphamide [SEP] nd characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener's granulomatosis. METHODS: In the pop", "tokenized_content": [2, 17135, 3, 8026, 30415, 1920, 2565, 1927, 7821, 2539, 16, 1930, 2496, 6147, 1942, 17135, 16, 1922, 2132, 1956, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 18, 2860, 30, 3]}, "items": [{"id": "p_4697", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4698", "content": "Wegener's granulomatosis [SEP]  cancer, and its relation to cyclophosphamide, in patients with Wegener's granulomatosis. METHODS: In the population based, nationwide Swedish Inpatient", "tokenized_content": [2, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 3, 2539, 16, 1930, 2496, 6147, 1942, 17135, 16, 1922, 2132, 1956, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 18, 2860, 3]}, "items": [{"id": "p_4698", "content": "Granulomatosis with Polyangiitis [SEP] A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) l", "score": 1, "type": null, "tokenized_content": [2, 25675, 4575, 8362, 1956, 4286, 9506, 3678, 3, 43, 13564, 2405, 1935, 2573, 1927, 43, 2796, 3299, 3872, 18, 2176, 1977, 4378, 2007, 4531, 1927, 1920, 2877, 7208, 12, 21548, 13, 54, 3]}]}
{"query": {"id": "q_4699", "content": "Cancer [SEP] osis, 1969-95, was identified. Through linkage with the Swedish Cancer Register, all subjects in this cohort diagnosed with bladder ca", "tokenized_content": [2, 2539, 3, 3125, 1937, 16, 22506, 17, 3002, 16, 1982, 2899, 18, 2596, 8611, 1956, 1920, 15110, 2539, 13801, 16, 2136, 3297, 1922, 2052, 4382, 5377, 1956, 7821, 2332, 3]}, "items": [{"id": "p_4699", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4700", "content": "L-arginine [SEP] L-arginine transport in humans with cortisol-induced hypertension.", "tokenized_content": [2, 54, 17, 9732, 3, 54, 17, 9732, 4860, 1922, 5209, 1956, 9806, 17, 2719, 5579, 18, 3]}, "items": [{"id": "p_4700", "content": "Arginine [SEP] An essential amino acid that is physiologically active in the L-form.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9732, 3, 1925, 4415, 3835, 2687, 1988, 1977, 15899, 3500, 1922, 1920, 54, 17, 2386, 18, 3]}]}
{"query": {"id": "q_4701", "content": "cortisol [SEP] L-arginine transport in humans with cortisol-induced hypertension.", "tokenized_content": [2, 9806, 3, 54, 17, 9732, 4860, 1922, 5209, 1956, 9806, 17, 2719, 5579, 18, 3]}, "items": [{"id": "p_4701", "content": "Hydrocortisone [SEP] The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, ", "score": 1, "type": null, "tokenized_content": [2, 28184, 3, 1920, 2730, 14469, 8366, 2007, 1920, 10651, 4997, 18, 2496, 6830, 18471, 1977, 2251, 16, 3108, 1966, 1925, 4107, 2014, 12259, 1954, 16, 3]}]}
{"query": {"id": "q_4702", "content": "hypertension [SEP] L-arginine transport in humans with cortisol-induced hypertension.", "tokenized_content": [2, 5579, 3, 54, 17, 9732, 4860, 1922, 5209, 1956, 9806, 17, 2719, 5579, 18, 3]}, "items": [{"id": "p_4702", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4703", "content": "L-arginine [SEP] A deficient L-arginine-nitric oxide system is implicated in cortisol-induced hypertens", "tokenized_content": [2, 54, 17, 9732, 3, 43, 5778, 54, 17, 9732, 17, 10233, 7491, 2433, 1977, 6835, 1922, 9806, 17, 2719, 4506, 2099, 3]}, "items": [{"id": "p_4703", "content": "Arginine [SEP] An essential amino acid that is physiologically active in the L-form.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9732, 3, 1925, 4415, 3835, 2687, 1988, 1977, 15899, 3500, 1922, 1920, 54, 17, 2386, 18, 3]}]}
{"query": {"id": "q_4704", "content": "nitric oxide [SEP] A deficient L-arginine-nitric oxide system is implicated in cortisol-induced hypertension. We inves", "tokenized_content": [2, 10233, 7491, 3, 43, 5778, 54, 17, 9732, 17, 10233, 7491, 2433, 1977, 6835, 1922, 9806, 17, 2719, 5579, 18, 2038, 2765, 3]}, "items": [{"id": "p_4704", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_4705", "content": "cortisol [SEP] A deficient L-arginine-nitric oxide system is implicated in cortisol-induced hypertension. We investigate whether abnormalities in L", "tokenized_content": [2, 9806, 3, 43, 5778, 54, 17, 9732, 17, 10233, 7491, 2433, 1977, 6835, 1922, 9806, 17, 2719, 5579, 18, 2038, 4482, 3053, 6754, 1922, 54, 3]}, "items": [{"id": "p_4705", "content": "Hydrocortisone [SEP] The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, ", "score": 1, "type": null, "tokenized_content": [2, 28184, 3, 1920, 2730, 14469, 8366, 2007, 1920, 10651, 4997, 18, 2496, 6830, 18471, 1977, 2251, 16, 3108, 1966, 1925, 4107, 2014, 12259, 1954, 16, 3]}]}
{"query": {"id": "q_4706", "content": "hypertension [SEP] -arginine-nitric oxide system is implicated in cortisol-induced hypertension. We investigate whether abnormalities in L-arginine uptake cont", "tokenized_content": [2, 5579, 3, 17, 9732, 17, 10233, 7491, 2433, 1977, 6835, 1922, 9806, 17, 2719, 5579, 18, 2038, 4482, 3053, 6754, 1922, 54, 17, 9732, 5047, 2120, 3]}, "items": [{"id": "p_4706", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4707", "content": "Hydrocortisone acetate [SEP] ontribute to this deficiency. Eight healthy men were recruited. Hydrocortisone acetate (50 mg) was given orally every 6 hours for 24 hours after a 5-d", "tokenized_content": [2, 28184, 7959, 3, 9056, 3027, 16119, 1021, 1942, 2052, 6179, 18, 5066, 4097, 3925, 1985, 6878, 18, 28184, 7959, 12, 2761, 2786, 13, 1982, 3258, 12950, 4808, 26, 3967, 1958, 3]}, "items": [{"id": "p_4707", "content": "hydrocortisone acetate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 28184, 7959, 3, 3]}]}
{"query": {"id": "q_4708", "content": "[3H]-l-arginine [SEP] with L-arginine (1 to 300 micromol/L), incorporating 100 nmol/L [3H]-l-arginine for a period of 5 minutes at 37 degrees C. Forearm [3H]-L-argin", "tokenized_content": [2, 37, 7648, 39, 17, 54, 17, 9732, 3, 1956, 54, 17, 9732, 12, 21, 1942, 5255, 25385, 19, 54, 13, 16, 12553, 2813, 11087, 19, 54, 37, 7648, 39, 17, 3]}, "items": [{"id": "p_4708", "content": "Arginine [SEP] An essential amino acid that is physiologically active in the L-form.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9732, 3, 1925, 4415, 3835, 2687, 1988, 1977, 15899, 3500, 1922, 1920, 54, 17, 2386, 18, 3]}]}
{"query": {"id": "q_4709", "content": "[3H]-L-arginine [SEP] ]-l-arginine for a period of 5 minutes at 37 degrees C. Forearm [3H]-L-arginine extraction was calculated after infusion of [3H]-L-arginine int", "tokenized_content": [2, 37, 7648, 39, 17, 54, 17, 9732, 3, 39, 17, 54, 17, 9732, 1958, 43, 3047, 1927, 25, 4814, 2019, 3191, 6429, 45, 18, 18652, 37, 7648, 39, 17, 54, 3]}, "items": [{"id": "p_4709", "content": "Arginine [SEP] An essential amino acid that is physiologically active in the L-form.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9732, 3, 1925, 4415, 3835, 2687, 1988, 1977, 15899, 3500, 1922, 1920, 54, 17, 2386, 18, 3]}]}
{"query": {"id": "q_4710", "content": "l-arginine [SEP] L-arginine (1 to 300 micromol/L), incorporating 100 nmol/L [3H]-l-arginine for a period of 5 minutes at 37 degrees C. Forearm [3H]-L-argin", "tokenized_content": [2, 54, 17, 9732, 3, 54, 17, 9732, 12, 21, 1942, 5255, 25385, 19, 54, 13, 16, 12553, 2813, 11087, 19, 54, 37, 7648, 39, 17, 54, 17, 9732, 1958, 43, 3]}, "items": [{"id": "p_4710", "content": "Arginine [SEP] An essential amino acid that is physiologically active in the L-form.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9732, 3, 1925, 4415, 3835, 2687, 1988, 1977, 15899, 3500, 1922, 1920, 54, 17, 2386, 18, 3]}]}
{"query": {"id": "q_4711", "content": "increases in blood pressure [SEP] hort-term cortisol treatment. We conclude that cortisol-induced increases in blood pressure are not associated with abnormalities in the l-arginine transpo", "tokenized_content": [2, 4041, 1922, 2877, 3772, 3, 7114, 1031, 17, 2576, 9806, 2311, 18, 2038, 7676, 1988, 9806, 17, 2719, 4041, 1922, 2877, 3772, 2032, 2084, 2458, 1956, 6754, 1922, 1920, 54, 3]}, "items": [{"id": "p_4711", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4712", "content": "tacrolimus [SEP] MR imaging with quantitative diffusion mapping of tacrolimus-induced neurotoxicity in organ transplant patients.", "tokenized_content": [2, 21801, 3, 2852, 3755, 1956, 4794, 6601, 7084, 1927, 21801, 17, 2719, 18034, 1922, 3090, 5192, 2132, 18, 3]}, "items": [{"id": "p_4712", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4713", "content": "neurotoxicity [SEP] aging with quantitative diffusion mapping of tacrolimus-induced neurotoxicity in organ transplant patients.", "tokenized_content": [2, 18034, 3, 6619, 1956, 4794, 6601, 7084, 1927, 21801, 17, 2719, 18034, 1922, 3090, 5192, 2132, 18, 3]}, "items": [{"id": "p_4713", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4714", "content": "tacrolimus [SEP] an transplant patients who developed neurologic symptoms during tacrolimus therapy. Brain MR studies, including DW imaging, were prospecti", "tokenized_content": [2, 21801, 3, 1925, 5192, 2132, 2746, 3530, 14314, 3601, 2409, 21801, 3181, 18, 3068, 2852, 2351, 16, 2710, 8927, 3755, 16, 1985, 29286, 1033, 3]}, "items": [{"id": "p_4714", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4715", "content": "neurologic complications [SEP] 14 organ transplant patients receiving tacrolimus who developed neurologic complications. In each patient who had abnormalities on the initial MR study,", "tokenized_content": [2, 14314, 5021, 3, 2607, 3090, 5192, 2132, 5962, 21801, 2746, 3530, 14314, 5021, 18, 1922, 2362, 2774, 2746, 2430, 6754, 1990, 1920, 3754, 2852, 2161, 16, 3]}, "items": [{"id": "p_4715", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4716", "content": "white matter abnormalities [SEP] reversibility of the lesions. Of the 14 patients, 5 (35.7%) had white matter abnormalities, 1 (7.1%) had putaminal hemorrhage, and 8 (57.1%) had normal fi", "tokenized_content": [2, 4511, 6537, 6754, 3, 28464, 1927, 1920, 4518, 18, 1927, 1920, 2607, 2132, 16, 25, 12, 3259, 18, 27, 9, 13, 2430, 4511, 6537, 6754, 16, 21, 12, 27, 18, 3]}, "items": [{"id": "p_4716", "content": "Leukoencephalopathies [SEP] Any of various diseases affecting the white matter of the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5104, 29159, 16038, 3, 2967, 1927, 3425, 3902, 7359, 1920, 4511, 6537, 1927, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_4717", "content": "putaminal hemorrhage [SEP] atients, 5 (35.7%) had white matter abnormalities, 1 (7.1%) had putaminal hemorrhage, and 8 (57.1%) had normal findings on initial MR images. Among ", "tokenized_content": [2, 5366, 3717, 1923, 10489, 3, 2019, 6746, 16, 25, 12, 3259, 18, 27, 9, 13, 2430, 4511, 6537, 6754, 16, 21, 12, 27, 18, 21, 9, 13, 2430, 5366, 3717, 3]}, "items": [{"id": "p_4717", "content": "Putaminal Hemorrhage [SEP] Intracranial bleeding into the PUTAMEN, a BASAL GANGLIA nucleus. This is associated with HYPERTENSION and lipohyalinosis of smal", "score": 1, "type": null, "tokenized_content": [2, 5366, 3717, 1923, 10489, 3, 12179, 7633, 2460, 1920, 21332, 16, 43, 5342, 13086, 5607, 18, 2052, 1977, 2458, 1956, 5579, 1930, 3178, 2977, 14081, 11096, 1937, 1927, 11953, 1024, 3]}]}
{"query": {"id": "q_4718", "content": "cortical laminar necrosis [SEP] wer than normal ADC value and showed incomplete resolution with cortical laminar necrosis. Diffusion-weighted imaging may be useful in predicting the out", "tokenized_content": [2, 5586, 22960, 7476, 3, 22210, 2254, 2791, 14219, 3113, 1930, 2594, 9876, 4885, 1956, 5586, 22960, 7476, 18, 6601, 17, 7370, 3755, 2278, 1998, 4707, 1922, 8779, 1920, 2397, 3]}, "items": [{"id": "p_4718", "content": "Brain Diseases [SEP] Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This ", "score": 1, "type": null, "tokenized_content": [2, 3068, 3902, 3, 11896, 2961, 7359, 1920, 3068, 16, 2154, 1977, 7179, 1927, 1920, 12179, 4178, 1927, 1920, 4101, 7580, 2433, 18, 2052, 3]}]}
{"query": {"id": "q_4719", "content": "neurotoxicity [SEP] in predicting the outcomes of the lesions of tacrolimus-induced neurotoxicity.", "tokenized_content": [2, 18034, 3, 1922, 8779, 1920, 3685, 1927, 1920, 4518, 1927, 21801, 17, 2719, 18034, 18, 3]}, "items": [{"id": "p_4719", "content": "Neurotoxicity Syndromes [SEP] Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method", "score": 1, "type": null, "tokenized_content": [2, 18034, 12688, 3, 14314, 4414, 4189, 2007, 3395, 1942, 6161, 10054, 2596, 14195, 16, 4107, 16, 11276, 4722, 16, 2014, 2303, 2417, 3]}]}
{"query": {"id": "q_4720", "content": "Octreotide [SEP] Octreotide-induced hypoxemia and pulmonary hypertension in premature neona", "tokenized_content": [2, 5843, 29351, 3, 5843, 29351, 17, 2719, 29881, 1930, 5352, 5579, 1922, 9839, 6621, 1019, 3]}, "items": [{"id": "p_4720", "content": "Octreotide [SEP] A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat h", "score": 1, "type": null, "tokenized_content": [2, 5843, 29351, 3, 43, 6828, 16, 2815, 17, 8290, 6830, 20698, 5843, 24010, 5729, 1988, 7042, 5512, 1927, 2905, 6365, 1930, 1977, 2251, 1942, 2297, 50, 3]}]}
{"query": {"id": "q_4721", "content": "hypoxemia [SEP] Octreotide-induced hypoxemia and pulmonary hypertension in premature neonates.", "tokenized_content": [2, 29881, 3, 5843, 29351, 17, 2719, 29881, 1930, 5352, 5579, 1922, 9839, 13250, 18, 3]}, "items": [{"id": "p_4721", "content": "Anoxia [SEP] Relatively complete absence of oxygen in one or more tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28976, 18068, 1019, 3, 4322, 4080, 3905, 1927, 4612, 1922, 2340, 2014, 2253, 3878, 18, 3]}]}
{"query": {"id": "q_4722", "content": "pulmonary hypertension [SEP] Octreotide-induced hypoxemia and pulmonary hypertension in premature neonates.", "tokenized_content": [2, 5352, 5579, 3, 5843, 29351, 17, 2719, 29881, 1930, 5352, 5579, 1922, 9839, 13250, 18, 3]}, "items": [{"id": "p_4722", "content": "Hypertension, Pulmonary [SEP] Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 5352, 3, 2502, 4541, 3554, 1922, 1920, 5352, 9255, 16, 5394, 4067, 1942, 4003, 3902, 2014, 3614, 3902, 18, 3]}]}
{"query": {"id": "q_4723", "content": "fistula [SEP] rs report 2 cases of premature neonates who had enterocutaneous fistula complicating necrotizing enterocolitis. Pulmonary hypertension ", "tokenized_content": [2, 15881, 3, 4366, 3809, 22, 2919, 1927, 9839, 13250, 2746, 2430, 5553, 29011, 15881, 6581, 6102, 2104, 27438, 5553, 23338, 3678, 18, 5352, 5579, 3]}, "items": [{"id": "p_4723", "content": "Fistula [SEP] Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.", "score": 1, "type": null, "tokenized_content": [2, 15881, 3, 4552, 6396, 2501, 5384, 3945, 2192, 2288, 4495, 7393, 16, 2014, 2192, 1925, 4495, 3090, 1930, 1920, 3154, 1927, 1920, 3362, 18, 3]}]}
{"query": {"id": "q_4724", "content": "necrotizing enterocolitis [SEP] premature neonates who had enterocutaneous fistula complicating necrotizing enterocolitis. Pulmonary hypertension developed after administration of a som", "tokenized_content": [2, 27438, 5553, 23338, 3678, 3, 9839, 13250, 2746, 2430, 5553, 29011, 15881, 6581, 6102, 2104, 27438, 5553, 23338, 3678, 18, 5352, 5579, 3530, 2256, 4183, 1927, 43, 5714, 3]}, "items": [{"id": "p_4724", "content": "Enterocolitis, Necrotizing [SEP] ENTEROCOLITIS with extensive ulceration (ULCER) and NECROSIS. It is observed primarily in LOW BIRTH WEIGHT INFANT.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5553, 23338, 3678, 16, 27438, 3, 5553, 23338, 3678, 1956, 6475, 23509, 12, 10096, 13, 1930, 7476, 18, 2176, 1977, 2528, 5985, 1922, 2330, 5043, 3388, 8125, 18, 3]}]}
{"query": {"id": "q_4725", "content": "Pulmonary hypertension [SEP] enterocutaneous fistula complicating necrotizing enterocolitis. Pulmonary hypertension developed after administration of a somatostatin analogue, octr", "tokenized_content": [2, 5352, 5579, 3, 5553, 29011, 15881, 6581, 6102, 2104, 27438, 5553, 23338, 3678, 18, 5352, 5579, 3530, 2256, 4183, 1927, 43, 20698, 12980, 16, 5843, 1005, 3]}, "items": [{"id": "p_4725", "content": "Hypertension, Pulmonary [SEP] Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 5352, 3, 2502, 4541, 3554, 1922, 1920, 5352, 9255, 16, 5394, 4067, 1942, 4003, 3902, 2014, 3614, 3902, 18, 3]}]}
{"query": {"id": "q_4726", "content": "octreotide [SEP] sion developed after administration of a somatostatin analogue, octreotide, to enhance resolution of the fistula. The authors discuss the ", "tokenized_content": [2, 5843, 29351, 3, 5998, 1916, 3530, 2256, 4183, 1927, 43, 20698, 12980, 16, 5843, 29351, 16, 1942, 4826, 4885, 1927, 1920, 15881, 18, 1920, 3875, 3891, 1920, 3]}, "items": [{"id": "p_4726", "content": "Octreotide [SEP] A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat h", "score": 1, "type": null, "tokenized_content": [2, 5843, 29351, 3, 43, 6828, 16, 2815, 17, 8290, 6830, 20698, 5843, 24010, 5729, 1988, 7042, 5512, 1927, 2905, 6365, 1930, 1977, 2251, 1942, 2297, 50, 3]}]}
{"query": {"id": "q_4727", "content": "exencephaly [SEP] Sequential observations of exencephaly and subsequent morphological changes by mouse exo utero develop", "tokenized_content": [2, 1975, 12217, 1012, 3, 9454, 5184, 1927, 1975, 12217, 1012, 1930, 4521, 7060, 2840, 2007, 3321, 18930, 19738, 2392, 3]}, "items": [{"id": "p_4727", "content": "Neural Tube Defects [SEP] Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during t", "score": 1, "type": null, "tokenized_content": [2, 5181, 6723, 6007, 3, 9901, 17360, 1927, 1920, 4101, 7580, 2433, 1930, 6811, 4061, 2712, 1942, 9785, 5181, 6723, 10408, 2409, 62, 3]}]}
{"query": {"id": "q_4728", "content": "anencephaly [SEP] analysis of the mechanism of transformation from exencephaly to anencephaly.", "tokenized_content": [2, 9860, 15895, 2128, 7289, 1012, 3, 2333, 1927, 1920, 2856, 1927, 7002, 2037, 1975, 12217, 1012, 1942, 9860, 15895, 2128, 7289, 1012, 18, 3]}, "items": [{"id": "p_4728", "content": "Anencephaly [SEP] A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal c", "score": 1, "type": null, "tokenized_content": [2, 9860, 15895, 2128, 7289, 1012, 3, 43, 22138, 1927, 1920, 7580, 2433, 4189, 2007, 4574, 1927, 1920, 5477, 13889, 2073, 1942, 5428, 18, 5969, 2032, 8813, 1956, 6718, 6071, 45, 3]}]}
{"query": {"id": "q_4729", "content": "Anencephaly [SEP] Anencephaly has been suggested to develop from exencephaly; however, there ", "tokenized_content": [2, 9860, 15895, 2128, 7289, 1012, 3, 9860, 15895, 2128, 7289, 1012, 2258, 2252, 3978, 1942, 2392, 2037, 1975, 12217, 1012, 31, 2406, 16, 2276, 3]}, "items": [{"id": "p_4729", "content": "Anencephaly [SEP] A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal c", "score": 1, "type": null, "tokenized_content": [2, 9860, 15895, 2128, 7289, 1012, 3, 43, 22138, 1927, 1920, 7580, 2433, 4189, 2007, 4574, 1927, 1920, 5477, 13889, 2073, 1942, 5428, 18, 5969, 2032, 8813, 1956, 6718, 6071, 45, 3]}]}
{"query": {"id": "q_4730", "content": "exencephaly [SEP] Anencephaly has been suggested to develop from exencephaly; however, there is little direct experimental evidence to suppo", "tokenized_content": [2, 1975, 12217, 1012, 3, 9860, 15895, 2128, 7289, 1012, 2258, 2252, 3978, 1942, 2392, 2037, 1975, 12217, 1012, 31, 2406, 16, 2276, 1977, 5082, 3083, 3599, 3095, 1942, 17528, 1037, 3]}, "items": [{"id": "p_4730", "content": "Neural Tube Defects [SEP] Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during t", "score": 1, "type": null, "tokenized_content": [2, 5181, 6723, 6007, 3, 9901, 17360, 1927, 1920, 4101, 7580, 2433, 1930, 6811, 4061, 2712, 1942, 9785, 5181, 6723, 10408, 2409, 62, 3]}]}
{"query": {"id": "q_4731", "content": "5-azacytidine [SEP] gestation mouse embryos. We observed the exencephaly induced by 5-azacytidine at embryonic day 13.5 (E13.5), let the embryos develop exo uter", "tokenized_content": [2, 25, 17, 19244, 27932, 5802, 3, 10879, 3321, 6274, 18, 2038, 2528, 1920, 1975, 12217, 1012, 2719, 2007, 25, 17, 19244, 27932, 5802, 2019, 7231, 3007, 2590, 18, 25, 12, 3]}, "items": [{"id": "p_4731", "content": "Azacitidine [SEP] A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, ", "score": 1, "type": null, "tokenized_content": [2, 19244, 3349, 10873, 3, 43, 21611, 12980, 1988, 7042, 2678, 16478, 16, 25648, 2678, 5547, 18, 2176, 1977, 2222, 1925, 20330, 9215, 4627, 12191, 2057, 1927, 2702, 5802, 16, 3]}]}
{"query": {"id": "q_4732", "content": "anencephaly [SEP] e confirmed several cases of transformation from exencephaly to anencephaly. However, in many cases, the exencephalic brain tissue was pres", "tokenized_content": [2, 9860, 15895, 2128, 7289, 1012, 3, 47, 3982, 2980, 2919, 1927, 7002, 2037, 1975, 12217, 1012, 1942, 9860, 15895, 2128, 7289, 1012, 18, 2406, 16, 1922, 3086, 2919, 16, 1920, 3]}, "items": [{"id": "p_4732", "content": "Anencephaly [SEP] A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal c", "score": 1, "type": null, "tokenized_content": [2, 9860, 15895, 2128, 7289, 1012, 3, 43, 22138, 1927, 1920, 7580, 2433, 4189, 2007, 4574, 1927, 1920, 5477, 13889, 2073, 1942, 5428, 18, 5969, 2032, 8813, 1956, 6718, 6071, 45, 3]}]}
{"query": {"id": "q_4733", "content": "exencephalic [SEP] on from exencephaly to anencephaly. However, in many cases, the exencephalic brain tissue was preserved with more or less reduction during t", "tokenized_content": [2, 1975, 28001, 3, 1990, 2037, 1975, 12217, 1012, 1942, 9860, 15895, 2128, 7289, 1012, 18, 2406, 16, 1922, 3086, 2919, 16, 1920, 1975, 28001, 3068, 2960, 1982, 10502, 1956, 2253, 3]}, "items": [{"id": "p_4733", "content": "Neural Tube Defects [SEP] Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during t", "score": 1, "type": null, "tokenized_content": [2, 5181, 6723, 6007, 3, 9901, 17360, 1927, 1920, 4101, 7580, 2433, 1930, 6811, 4061, 2712, 1942, 9785, 5181, 6723, 10408, 2409, 62, 3]}]}
{"query": {"id": "q_4734", "content": "hemorrhaging [SEP] tion showed the configuration of exencephaly at E13.5, frequent hemorrhaging and detachment of the neural plate from surface ectoderm in the", "tokenized_content": [2, 8492, 3196, 3, 8685, 1916, 2594, 1920, 9674, 1927, 1975, 12217, 1012, 2019, 24877, 18, 25, 16, 6439, 8492, 3196, 1930, 16293, 1927, 1920, 5181, 5500, 2037, 3154, 27177, 1922, 3]}, "items": [{"id": "p_4734", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_4735", "content": "circulatory failure [SEP] altered distribution patterns of vessels, subsequent peripheral circulatory failure and/or hemorrhaging in various parts of the exencephalic head, ", "tokenized_content": [2, 19844, 4574, 3, 5520, 3282, 4147, 1927, 7208, 16, 4521, 5009, 19844, 4574, 1930, 19, 2014, 8492, 3196, 1922, 3425, 7516, 1927, 1920, 1975, 28001, 4469, 16, 3]}, "items": [{"id": "p_4735", "content": "Shock [SEP] A pathological condition manifested by failure to perfuse or oxygenate vital organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7418, 3, 43, 6598, 2625, 16687, 2007, 4574, 1942, 5294, 2517, 2014, 4612, 2010, 8970, 7393, 18, 3]}]}
{"query": {"id": "q_4736", "content": "cocaine [SEP] Acute cocaine-induced seizures: differential sensitivity of six inbred mouse ", "tokenized_content": [2, 9045, 3, 3939, 9045, 17, 2719, 10060, 30, 5611, 3802, 1927, 3798, 19203, 3321, 3]}, "items": [{"id": "p_4736", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4737", "content": "seizures [SEP] Acute cocaine-induced seizures: differential sensitivity of six inbred mouse strains.", "tokenized_content": [2, 10060, 3, 3939, 9045, 17, 2719, 10060, 30, 5611, 3802, 1927, 3798, 19203, 3321, 4046, 18, 3]}, "items": [{"id": "p_4737", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4738", "content": "seizures [SEP]  six inbred stains were tested for susceptibility to behavioral seizures induced by a single injection of cocaine. Cocaine was injected ", "tokenized_content": [2, 10060, 3, 3798, 19203, 20981, 1985, 3620, 1958, 6461, 1942, 5343, 10060, 2719, 2007, 43, 2957, 4107, 1927, 9045, 18, 9045, 1982, 5624, 3]}, "items": [{"id": "p_4738", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4739", "content": "cocaine [SEP] ibility to behavioral seizures induced by a single injection of cocaine. Cocaine was injected ip over a range of doses (50-100 mg/kg) a", "tokenized_content": [2, 9045, 3, 6180, 2275, 1942, 5343, 10060, 2719, 2007, 43, 2957, 4107, 1927, 9045, 18, 9045, 1982, 5624, 5416, 2338, 43, 3109, 1927, 5312, 12, 2761, 17, 2813, 2786, 19, 3]}, "items": [{"id": "p_4739", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4740", "content": "Cocaine [SEP] o behavioral seizures induced by a single injection of cocaine. Cocaine was injected ip over a range of doses (50-100 mg/kg) and behavi", "tokenized_content": [2, 9045, 3, 57, 5343, 10060, 2719, 2007, 43, 2957, 4107, 1927, 9045, 18, 9045, 1982, 5624, 5416, 2338, 43, 3109, 1927, 5312, 12, 2761, 17, 2813, 2786, 19, 3621, 13, 3]}, "items": [{"id": "p_4740", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_4741", "content": "Seizure [SEP] doses (50-100 mg/kg) and behavior was monitored for 20 minutes. Seizure end points included latency to forelimb or hindlimb clonus, lat", "tokenized_content": [2, 11015, 3, 5312, 12, 2761, 17, 2813, 2786, 19, 3621, 13, 1930, 3379, 1982, 7027, 1958, 2036, 4814, 18, 11015, 2482, 4273, 3063, 9393, 1942, 27582, 2014, 24887, 6138, 1957, 3]}, "items": [{"id": "p_4741", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4742", "content": "seizure [SEP]  six inbred stains were tested for susceptibility to behavioral seizures induced by a single injection of cocaine. Cocaine was injected", "tokenized_content": [2, 11015, 3, 3798, 19203, 20981, 1985, 3620, 1958, 6461, 1942, 5343, 10060, 2719, 2007, 43, 2957, 4107, 1927, 9045, 18, 9045, 1982, 5624, 3]}, "items": [{"id": "p_4742", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4743", "content": "Microangiopathic hemolytic anemia [SEP] Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy.", "tokenized_content": [2, 2703, 9506, 10982, 21515, 10679, 3, 2703, 9506, 10982, 21515, 10679, 6581, 6102, 2104, 30269, 12, 21801, 13, 3181, 18, 3]}, "items": [{"id": "p_4743", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_4744", "content": "FK506 [SEP] Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy.", "tokenized_content": [2, 30269, 3, 2703, 9506, 10982, 21515, 10679, 6581, 6102, 2104, 30269, 12, 21801, 13, 3181, 18, 3]}, "items": [{"id": "p_4744", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4745", "content": "tacrolimus [SEP] Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy.", "tokenized_content": [2, 21801, 3, 2703, 9506, 10982, 21515, 10679, 6581, 6102, 2104, 30269, 12, 21801, 13, 3181, 18, 3]}, "items": [{"id": "p_4745", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4746", "content": "microangiopathic hemolytic anemia [SEP] We describe 3 episodes of microangiopathic hemolytic anemia (MAHA) in 2 solid organ recipients under FK506 (tacrolimus) the", "tokenized_content": [2, 2703, 9506, 10982, 21515, 10679, 3, 2038, 5993, 23, 9232, 1927, 2703, 9506, 10982, 21515, 10679, 12, 18770, 1019, 13, 1922, 22, 5358, 3090, 9336, 2441, 30269, 12, 21801, 13, 3]}, "items": [{"id": "p_4746", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_4747", "content": "MAHA [SEP] We describe 3 episodes of microangiopathic hemolytic anemia (MAHA) in 2 solid organ recipients under FK506 (tacrolimus) therapy. ", "tokenized_content": [2, 18770, 1019, 3, 2038, 5993, 23, 9232, 1927, 2703, 9506, 10982, 21515, 10679, 12, 18770, 1019, 13, 1922, 22, 5358, 3090, 9336, 2441, 30269, 12, 21801, 13, 3181, 18, 3]}, "items": [{"id": "p_4747", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_4748", "content": "FK506 [SEP] athic hemolytic anemia (MAHA) in 2 solid organ recipients under FK506 (tacrolimus) therapy. In both cases, discontinuation of FK506 a", "tokenized_content": [2, 30269, 3, 9468, 1935, 21515, 10679, 12, 18770, 1019, 13, 1922, 22, 5358, 3090, 9336, 2441, 30269, 12, 21801, 13, 3181, 18, 1922, 2321, 2919, 16, 14775, 1927, 30269, 43, 3]}, "items": [{"id": "p_4748", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4749", "content": "tacrolimus [SEP] emolytic anemia (MAHA) in 2 solid organ recipients under FK506 (tacrolimus) therapy. In both cases, discontinuation of FK506 and treatment", "tokenized_content": [2, 21801, 3, 5138, 1954, 2002, 10679, 12, 18770, 1019, 13, 1922, 22, 5358, 3090, 9336, 2441, 30269, 12, 21801, 13, 3181, 18, 1922, 2321, 2919, 16, 14775, 1927, 30269, 1930, 3]}, "items": [{"id": "p_4749", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_4750", "content": "corticosteroids [SEP] reatment with plasma exchange, fresh frozen plasma replacement, corticosteroids, aspirin, and dipyridamole led to resolution of MAHA. In one pa", "tokenized_content": [2, 14610, 3, 1964, 7647, 1956, 3582, 6818, 16, 6427, 8197, 3582, 7619, 16, 14610, 16, 12396, 16, 1930, 9137, 3553, 9532, 12492, 1952, 4866, 1942, 4885, 1927, 18770, 1019, 18, 3]}, "items": [{"id": "p_4750", "content": "Adrenal Cortex Hormones [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10651, 4997, 10224, 3, 3]}]}
{"query": {"id": "q_4751", "content": "aspirin [SEP] sma exchange, fresh frozen plasma replacement, corticosteroids, aspirin, and dipyridamole led to resolution of MAHA. In one patient, re", "tokenized_content": [2, 12396, 3, 11953, 6818, 16, 6427, 8197, 3582, 7619, 16, 14610, 16, 12396, 16, 1930, 9137, 3553, 9532, 12492, 1952, 4866, 1942, 4885, 1927, 18770, 1019, 18, 1922, 2340, 2774, 3]}, "items": [{"id": "p_4751", "content": "Aspirin [SEP] The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties a", "score": 1, "type": null, "tokenized_content": [2, 12396, 3, 1920, 29183, 14501, 2251, 1922, 1920, 2311, 1927, 5809, 1942, 5086, 3594, 18, 2176, 2258, 2246, 17, 3769, 1930, 2246, 18425, 3023, 3879, 43, 3]}]}
{"query": {"id": "q_4752", "content": "dipyridamole [SEP]  fresh frozen plasma replacement, corticosteroids, aspirin, and dipyridamole led to resolution of MAHA. In one patient, reintroduction of FK", "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 6427, 8197, 3582, 7619, 16, 14610, 16, 12396, 16, 1930, 9137, 3553, 9532, 12492, 1952, 4866, 1942, 4885, 1927, 18770, 1019, 18, 1922, 2340, 3]}, "items": [{"id": "p_4752", "content": "Dipyridamole [SEP] A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dip", "score": 1, "type": null, "tokenized_content": [2, 9137, 3553, 9532, 12492, 1952, 3, 43, 24821, 4106, 1988, 7644, 5047, 1930, 4714, 1927, 10125, 2007, 14161, 1930, 4541, 5003, 2094, 18, 9137, 3]}]}
{"query": {"id": "q_4753", "content": "cyclosporin A [SEP] ding to the literature, FK506 does not seem to cross-react with cyclosporin A (CyA), an immuno-suppressive drug already known to induce MAHA.", "tokenized_content": [2, 17640, 1921, 43, 3, 27147, 1942, 1920, 4431, 16, 30269, 3731, 2084, 6521, 1942, 3567, 17, 9793, 1956, 17640, 1921, 43, 12, 6002, 1019, 13, 16, 1925, 6595, 17, 14105, 3]}, "items": [{"id": "p_4753", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4754", "content": "CyA [SEP] erature, FK506 does not seem to cross-react with cyclosporin A (CyA), an immuno-suppressive drug already known to induce MAHA.", "tokenized_content": [2, 6002, 1019, 3, 14821, 4040, 16, 30269, 3731, 2084, 6521, 1942, 3567, 17, 9793, 1956, 17640, 1921, 43, 12, 6002, 1019, 13, 16, 1925, 6595, 17, 14105, 2838, 6064, 3171, 3]}, "items": [{"id": "p_4754", "content": "Cyclosporine [SEP] A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes.", "score": 1, "type": null, "tokenized_content": [2, 21002, 3, 43, 9821, 3075, 19384, 9626, 2410, 2261, 2037, 1925, 5869, 1927, 6072, 10520, 18, 2176, 1977, 43, 9974, 9312, 4479, 2031, 1956, 43, 2487, 4615, 1990, 62, 17, 7257, 18, 3]}]}
{"query": {"id": "q_4755", "content": "ventricular tachycardia [SEP] Variant ventricular tachycardia in desipramine toxicity.", "tokenized_content": [2, 6493, 17397, 3, 6031, 6493, 17397, 1922, 2270, 27085, 5532, 18, 3]}, "items": [{"id": "p_4755", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_4756", "content": "desipramine [SEP] Variant ventricular tachycardia in desipramine toxicity.", "tokenized_content": [2, 2270, 27085, 3, 6031, 6493, 17397, 1922, 2270, 27085, 5532, 18, 3]}, "items": [{"id": "p_4756", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_4757", "content": "toxicity [SEP] Variant ventricular tachycardia in desipramine toxicity.", "tokenized_content": [2, 5532, 3, 6031, 6493, 17397, 1922, 2270, 27085, 5532, 18, 3]}, "items": [{"id": "p_4757", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4758", "content": "ventricular tachycardia [SEP] We report a case of variant ventricular tachycardia induced by desipramine toxicity. Unusual features of the arrhyt", "tokenized_content": [2, 6493, 17397, 3, 2038, 3809, 43, 3087, 1927, 6031, 6493, 17397, 2719, 2007, 2270, 27085, 5532, 18, 12236, 4075, 1927, 1920, 3853, 30338, 1031, 3]}, "items": [{"id": "p_4758", "content": "Tachycardia, Ventricular [SEP] An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 6493, 3, 1925, 20756, 4052, 6493, 11529, 5394, 1922, 5799, 1927, 5493, 19380, 2079, 8623, 18, 2176, 1977, 3999, 2651, 1920, 11887, 4535, 1920, 3]}]}
{"query": {"id": "q_4759", "content": "desipramine [SEP] We report a case of variant ventricular tachycardia induced by desipramine toxicity. Unusual features of the arrhythmia are repetitive gro", "tokenized_content": [2, 2270, 27085, 3, 2038, 3809, 43, 3087, 1927, 6031, 6493, 17397, 2719, 2007, 2270, 27085, 5532, 18, 12236, 4075, 1927, 1920, 18346, 2032, 12089, 8947, 3]}, "items": [{"id": "p_4759", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_4760", "content": "toxicity [SEP]  case of variant ventricular tachycardia induced by desipramine toxicity. Unusual features of the arrhythmia are repetitive group beatin", "tokenized_content": [2, 5532, 3, 3087, 1927, 6031, 6493, 17397, 2719, 2007, 2270, 27085, 5532, 18, 12236, 4075, 1927, 1920, 18346, 2032, 12089, 2210, 17984, 1921, 3]}, "items": [{"id": "p_4760", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4761", "content": "arrhythmia [SEP] cardia induced by desipramine toxicity. Unusual features of the arrhythmia are repetitive group beating, progressive shortening of the R-R", "tokenized_content": [2, 18346, 3, 3215, 1019, 2719, 2007, 2270, 27085, 5532, 18, 12236, 4075, 1927, 1920, 18346, 2032, 12089, 2210, 24711, 16, 7529, 14177, 1927, 1920, 60, 17, 60, 3]}, "items": [{"id": "p_4761", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_4762", "content": "Desipramine [SEP] Desipramine-induced delirium at \"subtherapeutic\" concentrations: a case rep", "tokenized_content": [2, 2270, 27085, 3, 2270, 27085, 17, 2719, 18166, 2019, 6, 21652, 7124, 9626, 1984, 1935, 6, 3295, 30, 43, 3087, 3073, 3]}, "items": [{"id": "p_4762", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_4763", "content": "delirium [SEP] Desipramine-induced delirium at \"subtherapeutic\" concentrations: a case report.", "tokenized_content": [2, 18166, 3, 2270, 27085, 17, 2719, 18166, 2019, 6, 21652, 7124, 9626, 1984, 1935, 6, 3295, 30, 43, 3087, 3809, 18, 3]}, "items": [{"id": "p_4763", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_4764", "content": "Desipramine [SEP] An elderly patient treated with low dose Desipramine developed a delirium while her plasma level was in the \"subther", "tokenized_content": [2, 2270, 27085, 3, 1925, 7354, 2774, 2868, 1956, 2330, 3253, 2270, 27085, 3530, 43, 18166, 2679, 3656, 3582, 2237, 1982, 1922, 1920, 6, 21652, 1915, 3]}, "items": [{"id": "p_4764", "content": "Desipramine [SEP] A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine", "score": 1, "type": null, "tokenized_content": [2, 2270, 27085, 3, 43, 12258, 13153, 17239, 4389, 25360, 3547, 1988, 29734, 20221, 18, 2270, 27085, 9331, 7644, 22957, 1927, 16436, 3]}]}
{"query": {"id": "q_4765", "content": "delirium [SEP] n elderly patient treated with low dose Desipramine developed a delirium while her plasma level was in the \"subtherapeutic\" range. Delir", "tokenized_content": [2, 18166, 3, 56, 7354, 2774, 2868, 1956, 2330, 3253, 2270, 27085, 3530, 43, 18166, 2679, 3656, 3582, 2237, 1982, 1922, 1920, 6, 21652, 7124, 9626, 1984, 1935, 6, 3109, 18, 3]}, "items": [{"id": "p_4765", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_4766", "content": "Delirium [SEP] irium while her plasma level was in the \"subtherapeutic\" range. Delirium, which may be induced by tricyclic drug therapy in the elderly,", "tokenized_content": [2, 18166, 3, 24768, 1989, 2679, 3656, 3582, 2237, 1982, 1922, 1920, 6, 21652, 7124, 9626, 1984, 1935, 6, 3109, 18, 18166, 16, 2154, 2278, 1998, 2719, 2007, 12258, 13153, 2838, 3]}, "items": [{"id": "p_4766", "content": "Delirium [SEP] A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instan", "score": 1, "type": null, "tokenized_content": [2, 18166, 3, 43, 4770, 4378, 2007, 18272, 31, 27351, 8956, 2971, 31, 2054, 29292, 31, 3652, 3910, 31, 27013, 31, 18389, 31, 1930, 1922, 2673, 4766, 1928, 3]}]}
{"query": {"id": "q_4767", "content": "antidepressants [SEP] yclics with low anticholinergic potency. Therapeutic ranges for antidepressants that have been derived from general adult population studies ma", "tokenized_content": [2, 17722, 3, 22386, 3742, 1036, 1956, 2330, 5851, 12074, 12745, 10397, 18, 4272, 8939, 1958, 17722, 1988, 2162, 2252, 3595, 2037, 3335, 4160, 2973, 2351, 2488, 3]}, "items": [{"id": "p_4767", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_4768", "content": "amantadine [SEP] Mouse strain-dependent effect of amantadine on motility and brain biogenic amines.", "tokenized_content": [2, 2150, 23200, 27099, 3, 3321, 3943, 17, 3100, 2495, 1927, 2150, 23200, 27099, 1990, 9254, 1930, 3068, 24241, 19730, 20739, 18, 3]}, "items": [{"id": "p_4768", "content": "Amantadine [SEP] An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian ag", "score": 1, "type": null, "tokenized_content": [2, 2150, 23200, 27099, 3, 1925, 10129, 1988, 1977, 2251, 1922, 1920, 14847, 2014, 9371, 2311, 1927, 7108, 43, 18, 2176, 1977, 2222, 2251, 1966, 1925, 24290, 14488, 6114, 1022, 2260, 3]}]}
{"query": {"id": "q_4769", "content": "amines [SEP] n-dependent effect of amantadine on motility and brain biogenic amines.", "tokenized_content": [2, 20739, 3, 56, 17, 3100, 2495, 1927, 2150, 23200, 27099, 1990, 9254, 1930, 3068, 24241, 19730, 20739, 18, 3]}, "items": [{"id": "p_4769", "content": "Amines [SEP] A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dic", "score": 1, "type": null, "tokenized_content": [2, 20739, 3, 43, 2210, 1927, 4300, 3595, 2037, 14880, 2007, 26276, 6805, 12467, 1958, 1920, 6201, 1036, 18, 12, 2037, 6216, 10, 2118, 12940, 1023, 11, 61, 4399, 9192, 3]}]}
{"query": {"id": "q_4770", "content": "amantadine hydrochloride [SEP] The effect of amantadine hydrochloride, injected i.p. in 6 increments of 100 mg/kg each over 30 hr, on", "tokenized_content": [2, 2150, 23200, 27099, 16675, 3, 1920, 2495, 1927, 2150, 23200, 27099, 16675, 16, 5624, 51, 18, 58, 18, 1922, 26, 19401, 1927, 2813, 2786, 19, 3621, 2362, 2338, 2627, 3668, 3]}, "items": [{"id": "p_4770", "content": "Amantadine [SEP] An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian ag", "score": 1, "type": null, "tokenized_content": [2, 2150, 23200, 27099, 3, 1925, 10129, 1988, 1977, 2251, 1922, 1920, 14847, 2014, 9371, 2311, 1927, 7108, 43, 18, 2176, 1977, 2222, 2251, 1966, 1925, 24290, 14488, 6114, 1022, 2260, 3]}]}
{"query": {"id": "q_4771", "content": "amines [SEP]  on mouse motility and whole brain content of selected biogenic amines and major metabolites was studied in 4 strains of mice. These w", "tokenized_content": [2, 20739, 3, 1990, 3321, 9254, 1930, 4292, 3068, 3919, 1927, 3790, 24241, 19730, 20739, 1930, 3044, 6926, 1982, 3942, 1922, 24, 4046, 1927, 2518, 18, 2144, 65, 3]}, "items": [{"id": "p_4771", "content": "Amines [SEP] A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dic", "score": 1, "type": null, "tokenized_content": [2, 20739, 3, 43, 2210, 1927, 4300, 3595, 2037, 14880, 2007, 26276, 6805, 12467, 1958, 1920, 6201, 1036, 18, 12, 2037, 6216, 10, 2118, 12940, 1023, 11, 61, 4399, 9192, 3]}]}
{"query": {"id": "q_4772", "content": "Amantadine [SEP] nd BALB/C, the black C57BL/6 and the brown CDF-I mouse strains. Amantadine treatment produced a biphasic effect on mouse motility. The ini", "tokenized_content": [2, 2150, 23200, 27099, 3, 8026, 11721, 19, 45, 16, 1920, 5010, 8408, 19, 26, 1930, 1920, 8084, 2464, 1038, 17, 51, 3321, 4046, 18, 2150, 23200, 27099, 2311, 4152, 43, 3]}, "items": [{"id": "p_4772", "content": "Amantadine [SEP] An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian ag", "score": 1, "type": null, "tokenized_content": [2, 2150, 23200, 27099, 3, 1925, 10129, 1988, 1977, 2251, 1922, 1920, 14847, 2014, 9371, 2311, 1927, 7108, 43, 18, 2176, 1977, 2222, 2251, 1966, 1925, 24290, 14488, 6114, 1022, 2260, 3]}]}
{"query": {"id": "q_4773", "content": "amantadine [SEP] The effect of amantadine hydrochloride, injected i.p. in 6 increments of 100 mg/kg each ", "tokenized_content": [2, 2150, 23200, 27099, 3, 1920, 2495, 1927, 2150, 23200, 27099, 16675, 16, 5624, 51, 18, 58, 18, 1922, 26, 19401, 1927, 2813, 2786, 19, 3621, 2362, 3]}, "items": [{"id": "p_4773", "content": "Amantadine [SEP] An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian ag", "score": 1, "type": null, "tokenized_content": [2, 2150, 23200, 27099, 3, 1925, 10129, 1988, 1977, 2251, 1922, 1920, 14847, 2014, 9371, 2311, 1927, 7108, 43, 18, 2176, 1977, 2222, 2251, 1966, 1925, 24290, 14488, 6114, 1022, 2260, 3]}]}
{"query": {"id": "q_4774", "content": "depressed [SEP] phasic effect on mouse motility. The initial dose of amantadine depressed locomotor activity in all mouse strains studied with the BALB/C", "tokenized_content": [2, 11365, 3, 24328, 2495, 1990, 3321, 9254, 18, 1920, 3754, 3253, 1927, 2150, 23200, 27099, 11365, 13594, 2455, 1922, 2136, 3321, 4046, 3942, 1956, 1920, 11721, 19, 45, 3]}, "items": [{"id": "p_4774", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_4775", "content": "suppression of motility [SEP]  control in all strains with exception of the BALB/C mice where suppression of motility occurred. Treatment with amantadine did not alter whole brain d", "tokenized_content": [2, 6412, 1927, 9254, 3, 2285, 1922, 2136, 4046, 1956, 7541, 1927, 1920, 11721, 19, 45, 2518, 2597, 6412, 1927, 9254, 4807, 18, 2311, 1956, 2150, 23200, 27099, 2811, 2084, 4238, 3]}, "items": [{"id": "p_4775", "content": "Psychomotor Disorders [SEP] Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26261, 4414, 3, 6754, 1927, 4842, 2347, 1988, 2032, 2458, 1956, 6805, 1930, 2447, 17, 6805, 4328, 4414, 18, 3]}]}
{"query": {"id": "q_4776", "content": "dopamine [SEP] y occurred. Treatment with amantadine did not alter whole brain dopamine levels but decreased the amounts of 3,4-dihydroxyphenylacetic a", "tokenized_content": [2, 7964, 3, 67, 4807, 18, 2311, 1956, 2150, 23200, 27099, 2811, 2084, 4238, 4292, 3068, 7964, 2428, 2308, 3261, 1920, 6222, 1927, 23, 16, 24, 17, 20684, 17616, 2199, 13722, 3]}, "items": [{"id": "p_4776", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4777", "content": "3,4-dihydroxyphenylacetic acid [SEP]  alter whole brain dopamine levels but decreased the amounts of 3,4-dihydroxyphenylacetic acid in the BALB/C mice compared to saline control. Conversely, brai", "tokenized_content": [2, 23, 16, 24, 17, 20684, 17616, 2199, 13722, 2687, 3, 4238, 4292, 3068, 7964, 2428, 2308, 3261, 1920, 6222, 1927, 23, 16, 24, 17, 20684, 17616, 2199, 13722, 2687, 1922, 3]}, "items": [{"id": "p_4777", "content": "3,4-Dihydroxyphenylacetic Acid [SEP] A deaminated metabolite of LEVODOPA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23, 16, 24, 17, 20684, 17616, 2199, 13722, 2687, 3, 43, 30097, 8547, 1981, 9483, 1927, 26723, 18, 3]}]}
{"query": {"id": "q_4778", "content": "normetanephrine [SEP] n the BALB/C mice compared to saline control. Conversely, brain normetanephrine concentration was increased from saline control by amantadine i", "tokenized_content": [2, 5308, 26598, 2128, 6570, 2053, 3, 56, 1920, 11721, 19, 45, 2518, 2452, 1942, 5977, 2285, 18, 8990, 16, 3068, 5308, 26598, 2128, 6570, 2053, 3110, 1982, 2502, 2037, 5977, 3]}, "items": [{"id": "p_4778", "content": "Normetanephrine [SEP] A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.", "score": 1, "type": null, "tokenized_content": [2, 5308, 26598, 2128, 6570, 2053, 3, 43, 11882, 9483, 1927, 16436, 1988, 1977, 22182, 1922, 1920, 6960, 1930, 2435, 1922, 4908, 3878, 18, 2176, 1977, 43, 4966, 1958, 3861, 18, 3]}]}
{"query": {"id": "q_4779", "content": "catecholamine [SEP] ic amines of BALB/C mouse strain suggest a probable decrease of catecholamine turnover rate and/or metabolism by monoamine oxidase and a resu", "tokenized_content": [2, 23483, 3, 3996, 20739, 1927, 11721, 19, 45, 3321, 3943, 3220, 43, 12584, 3714, 1927, 23483, 9781, 2769, 1930, 19, 2014, 4714, 2007, 25368, 10488, 1930, 43, 1995, 1032, 3]}, "items": [{"id": "p_4779", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_4780", "content": "norepinephrine [SEP]  monoamine oxidase and a resulting increase in O-methylation of norepinephrine which may account for a behavioral depression caused by amantad", "tokenized_content": [2, 16436, 3, 25368, 10488, 1930, 43, 3864, 2760, 1922, 57, 17, 5547, 1927, 16436, 2154, 2278, 5042, 1958, 43, 5343, 4621, 4189, 2007, 2150, 23200, 1007, 3]}, "items": [{"id": "p_4780", "content": "Norepinephrine [SEP] Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Nor", "score": 1, "type": null, "tokenized_content": [2, 16436, 3, 7897, 1927, 19280, 1988, 1977, 8366, 2007, 1920, 10651, 18755, 1930, 1977, 43, 9360, 4101, 1930, 13725, 15223, 18, 3990, 3]}]}
{"query": {"id": "q_4781", "content": "behavioral depression [SEP] ease in O-methylation of norepinephrine which may account for a behavioral depression caused by amantadine in the BALB/C mice.", "tokenized_content": [2, 5343, 4621, 3, 13832, 1922, 57, 17, 5547, 1927, 16436, 2154, 2278, 5042, 1958, 43, 5343, 4621, 4189, 2007, 2150, 23200, 27099, 1922, 1920, 11721, 19, 45, 2518, 18, 3]}, "items": [{"id": "p_4781", "content": "Psychomotor Disorders [SEP] Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26261, 4414, 3, 6754, 1927, 4842, 2347, 1988, 2032, 2458, 1956, 6805, 1930, 2447, 17, 6805, 4328, 4414, 18, 3]}]}
{"query": {"id": "q_4782", "content": "phenobarbital [SEP] No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the ra", "tokenized_content": [2, 3037, 18986, 3, 2239, 7489, 2007, 3037, 18986, 1927, 1920, 5746, 7907, 12758, 1927, 43, 15440, 17, 18327, 3986, 1922, 1920, 4313, 3]}, "items": [{"id": "p_4782", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_4783", "content": "choline [SEP]  enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat.", "tokenized_content": [2, 15440, 3, 7489, 2007, 3037, 18986, 1927, 1920, 5746, 7907, 12758, 1927, 43, 15440, 17, 18327, 3986, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_4783", "content": "Choline [SEP] A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine,", "score": 1, "type": null, "tokenized_content": [2, 15440, 3, 43, 5937, 18690, 1927, 18430, 1953, 1921, 1988, 1977, 2435, 1922, 3086, 4793, 1930, 4027, 7393, 18, 2176, 1977, 2715, 1966, 43, 7897, 1927, 14561, 16, 3]}]}
{"query": {"id": "q_4784", "content": "phenobarbital [SEP] An experiment was performed to test whether inclusion of phenobarbital in a choline-devoid diet would increase the hepatocarcinogenici", "tokenized_content": [2, 3037, 18986, 3, 1925, 3859, 1982, 2593, 1942, 2648, 3053, 6125, 1927, 3037, 18986, 1922, 43, 15440, 17, 18327, 3986, 2962, 2760, 1920, 5746, 7907, 3880, 1033, 3]}, "items": [{"id": "p_4784", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_4785", "content": "choline [SEP] t was performed to test whether inclusion of phenobarbital in a choline-devoid diet would increase the hepatocarcinogenicity of the die", "tokenized_content": [2, 15440, 3, 62, 1982, 2593, 1942, 2648, 3053, 6125, 1927, 3037, 18986, 1922, 43, 15440, 17, 18327, 3986, 2962, 2760, 1920, 5746, 7907, 12758, 1927, 1920, 8769, 3]}, "items": [{"id": "p_4785", "content": "Choline [SEP] A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine,", "score": 1, "type": null, "tokenized_content": [2, 15440, 3, 43, 5937, 18690, 1927, 18430, 1953, 1921, 1988, 1977, 2435, 1922, 3086, 4793, 1930, 4027, 7393, 18, 2176, 1977, 2715, 1966, 43, 7897, 1927, 14561, 16, 3]}]}
{"query": {"id": "q_4786", "content": "hepatocellular carcinomas [SEP] or not 0.06% phenobarbital. No hepatic preneoplastic nodules or hepatocellular carcinomas developed in rats fed the plain choline-supplemented diet, whil", "tokenized_content": [2, 12457, 10691, 3, 2014, 2084, 20, 18, 6604, 9, 3037, 18986, 18, 2239, 6095, 9972, 1021, 9969, 12128, 2014, 12457, 10691, 3530, 1922, 3615, 5788, 1920, 16739, 15440, 17, 6359, 3]}, "items": [{"id": "p_4786", "content": "Carcinoma, Hepatocellular [SEP] A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indisti", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 12457, 3, 43, 3065, 6558, 12132, 1927, 4944, 3568, 2094, 18, 2176, 8939, 2037, 43, 2486, 17, 7512, 2798, 1956, 4944, 2094, 16643, 1914, 3]}]}
{"query": {"id": "q_4787", "content": "hepatocellular carcinoma [SEP] or not 0.06% phenobarbital. No hepatic preneoplastic nodules or hepatocellular carcinomas developed in rats fed the plain choline-supplemented diet, whi", "tokenized_content": [2, 12457, 5373, 3, 2014, 2084, 20, 18, 6604, 9, 3037, 18986, 18, 2239, 6095, 9972, 1021, 9969, 12128, 2014, 12457, 10691, 3530, 1922, 3615, 5788, 1920, 16739, 15440, 17, 6359, 3]}, "items": [{"id": "p_4787", "content": "Carcinoma, Hepatocellular [SEP] A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indisti", "score": 1, "type": null, "tokenized_content": [2, 5373, 16, 12457, 3, 43, 3065, 6558, 12132, 1927, 4944, 3568, 2094, 18, 2176, 8939, 2037, 43, 2486, 17, 7512, 2798, 1956, 4944, 2094, 16643, 1914, 3]}]}
{"query": {"id": "q_4788", "content": "methylergonovine [SEP] Effect of direct intracoronary administration of methylergonovine in patients with and without variant angina.", "tokenized_content": [2, 4963, 2693, 23557, 23551, 3, 2495, 1927, 3083, 4245, 30515, 2141, 4183, 1927, 4963, 2693, 23557, 23551, 1922, 2132, 1956, 1930, 2979, 6031, 16961, 18, 3]}, "items": [{"id": "p_4788", "content": "Methylergonovine [SEP] A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 4963, 2693, 23557, 23551, 3, 43, 5928, 1927, 11949, 23557, 23551, 3165, 2340, 2253, 11164, 2210, 18, 12, 14556, 3867, 16, 2513, 1963, 3347, 13, 3]}]}
{"query": {"id": "q_4789", "content": "variant angina [SEP] administration of methylergonovine in patients with and without variant angina.", "tokenized_content": [2, 6031, 16961, 3, 4183, 1927, 4963, 2693, 23557, 23551, 1922, 2132, 1956, 1930, 2979, 6031, 16961, 18, 3]}, "items": [{"id": "p_4789", "content": "Angina Pectoris, Variant [SEP] A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in th", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 16, 6031, 3, 43, 2535, 4741, 4378, 2007, 1920, 2740, 1927, 8475, 3594, 2019, 6172, 1956, 8537, 6809, 1955, 5367, 8644, 1922, 1913, 3]}]}
{"query": {"id": "q_4790", "content": "methylergonovine [SEP] The effects of intracoronary administration of methylergonovine were studied in 21 patients with variant angina and 22 patients", "tokenized_content": [2, 4963, 2693, 23557, 23551, 3, 1920, 2564, 1927, 4245, 30515, 2141, 4183, 1927, 4963, 2693, 23557, 23551, 1985, 3942, 1922, 2900, 2132, 1956, 6031, 16961, 1930, 2950, 2132, 3]}, "items": [{"id": "p_4790", "content": "Methylergonovine [SEP] A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 4963, 2693, 23557, 23551, 3, 43, 5928, 1927, 11949, 23557, 23551, 3165, 2340, 2253, 11164, 2210, 18, 12, 14556, 3867, 16, 2513, 1963, 3347, 13, 3]}]}
{"query": {"id": "q_4791", "content": "variant angina [SEP] nistration of methylergonovine were studied in 21 patients with variant angina and 22 patients with atypical chest pain and in others without ", "tokenized_content": [2, 6031, 16961, 3, 17299, 6003, 1927, 4963, 2693, 23557, 23551, 1985, 3942, 1922, 2900, 2132, 1956, 6031, 16961, 1930, 2950, 2132, 1956, 10834, 8475, 3594, 1930, 1922, 4991, 2979, 3]}, "items": [{"id": "p_4791", "content": "Angina Pectoris, Variant [SEP] A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in th", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 16, 6031, 3, 43, 2535, 4741, 4378, 2007, 1920, 2740, 1927, 8475, 3594, 2019, 6172, 1956, 8537, 6809, 1955, 5367, 8644, 1922, 1913, 3]}]}
{"query": {"id": "q_4792", "content": "chest pain [SEP] n 21 patients with variant angina and 22 patients with atypical chest pain and in others without angina pectoris (control group). Methyler", "tokenized_content": [2, 8475, 3594, 3, 56, 2900, 2132, 1956, 6031, 16961, 1930, 2950, 2132, 1956, 10834, 8475, 3594, 1930, 1922, 4991, 2979, 16961, 23540, 1937, 12, 2285, 2210, 13, 18, 4963, 1915, 3]}, "items": [{"id": "p_4792", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_4793", "content": "angina pectoris [SEP]  and 22 patients with atypical chest pain and in others without angina pectoris (control group). Methylergonovine was administered continuously", "tokenized_content": [2, 16961, 23540, 1937, 3, 1930, 2950, 2132, 1956, 10834, 8475, 3594, 1930, 1922, 4991, 2979, 16961, 23540, 1937, 12, 2285, 2210, 13, 18, 4963, 2693, 23557, 23551, 1982, 5254, 10446, 3]}, "items": [{"id": "p_4793", "content": "Angina Pectoris [SEP] The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 3, 1920, 3226, 1927, 28033, 3594, 16693, 1942, 6497, 7716, 5394, 1927, 15308, 2728, 16, 5185, 1930, 5442, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_4794", "content": "Methylergonovine [SEP] est pain and in others without angina pectoris (control group). Methylergonovine was administered continuously at a rate of 10 micrograms/min up", "tokenized_content": [2, 4963, 2693, 23557, 23551, 3, 3255, 3594, 1930, 1922, 4991, 2979, 16961, 23540, 1937, 12, 2285, 2210, 13, 18, 4963, 2693, 23557, 23551, 1982, 5254, 10446, 2019, 43, 2769, 1927, 3]}, "items": [{"id": "p_4794", "content": "Methylergonovine [SEP] A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 4963, 2693, 23557, 23551, 3, 43, 5928, 1927, 11949, 23557, 23551, 3165, 2340, 2253, 11164, 2210, 18, 12, 14556, 3867, 16, 2513, 1963, 3347, 13, 3]}]}
{"query": {"id": "q_4795", "content": "coronary spasm [SEP] s/min up to 50 micrograms. In all patients with variant angina, coronary spasm was provoked at a mean dose of 28 +/- 13 micrograms (mean +/- S", "tokenized_content": [2, 5846, 24431, 3, 61, 19, 2360, 2353, 1942, 2761, 13362, 18, 1922, 2136, 2132, 1956, 6031, 16961, 16, 5846, 24431, 1982, 27116, 2019, 43, 2667, 3253, 1927, 3158, 15, 19, 3]}, "items": [{"id": "p_4795", "content": "Coronary Vasospasm [SEP] Spasm of the large- or medium-sized coronary arteries.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5846, 22866, 3508, 2691, 3, 24431, 1927, 1920, 3103, 17, 2014, 3649, 17, 12177, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_4796", "content": "spasm [SEP] to 50 micrograms. In all patients with variant angina, coronary spasm was provoked at a mean dose of 28 +/- 13 micrograms (mean +/- S", "tokenized_content": [2, 24431, 3, 1942, 2761, 13362, 18, 1922, 2136, 2132, 1956, 6031, 16961, 16, 5846, 24431, 1982, 27116, 2019, 43, 2667, 3253, 1927, 3158, 15, 19, 17, 2590, 13362, 12, 2667, 3]}, "items": [{"id": "p_4796", "content": "Spasm [SEP] An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24431, 3, 1925, 28493, 8332, 1927, 43, 3760, 2014, 2210, 1927, 7848, 18, 24431, 1036, 2278, 8156, 7345, 3760, 2014, 6689, 3760, 18, 3]}]}
{"query": {"id": "q_4797", "content": "Dobutamine [SEP] Dobutamine stress echocardiography: a sensitive indicator of diminished my", "tokenized_content": [2, 2608, 16119, 3812, 3, 2608, 16119, 3812, 3071, 12814, 30, 43, 4532, 8413, 1927, 9597, 3057, 3]}, "items": [{"id": "p_4797", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_4798", "content": "doxorubicin [SEP] ive indicator of diminished myocardial function in asymptomatic doxorubicin-treated long-term survivors of childhood cancer.", "tokenized_content": [2, 12377, 3, 4370, 1021, 8413, 1927, 9597, 6497, 2347, 1922, 9978, 12377, 17, 2868, 2815, 17, 2576, 9408, 1927, 7238, 2539, 18, 3]}, "items": [{"id": "p_4798", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4799", "content": "cancer [SEP] ymptomatic doxorubicin-treated long-term survivors of childhood cancer.", "tokenized_content": [2, 2539, 3, 23143, 9750, 12377, 17, 2868, 2815, 17, 2576, 9408, 1927, 7238, 2539, 18, 3]}, "items": [{"id": "p_4799", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4800", "content": "Doxorubicin [SEP] Doxorubicin is an effective anticancer chemotherapeutic agent known to caus", "tokenized_content": [2, 12377, 3, 12377, 1977, 1925, 3655, 11515, 14124, 5899, 3171, 1942, 3092, 3]}, "items": [{"id": "p_4800", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4801", "content": "cardiomyopathy [SEP] icancer chemotherapeutic agent known to cause acute and chronic cardiomyopathy. To develop a more sensitive echocardiographic screening test f", "tokenized_content": [2, 14141, 3, 14784, 15895, 1915, 14124, 5899, 3171, 1942, 3936, 3939, 1930, 3724, 14141, 18, 1942, 2392, 43, 2253, 4532, 18700, 4449, 2648, 48, 3]}, "items": [{"id": "p_4801", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_4802", "content": "cardiac damage [SEP] o develop a more sensitive echocardiographic screening test for cardiac damage due to doxorubicin, a cohort study was performed using dobutami", "tokenized_content": [2, 4435, 4293, 3, 57, 2392, 43, 2253, 4532, 18700, 4449, 2648, 1958, 4435, 4293, 2810, 1942, 12377, 16, 43, 4382, 2161, 1982, 2593, 2193, 2608, 16119, 14981, 3]}, "items": [{"id": "p_4802", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_4803", "content": "doxorubicin [SEP] tive echocardiographic screening test for cardiac damage due to doxorubicin, a cohort study was performed using dobutamine infusion to diff", "tokenized_content": [2, 12377, 3, 8685, 1961, 18700, 4449, 2648, 1958, 4435, 4293, 2810, 1942, 12377, 16, 43, 4382, 2161, 1982, 2593, 2193, 2608, 16119, 3812, 7386, 1942, 3228, 3]}, "items": [{"id": "p_4803", "content": "Doxorubicin [SEP] Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12377, 3, 29128, 9969, 7267, 2926, 2037, 22874, 2737, 3005, 1914, 1957, 18, 2176, 1977, 43, 8275, 10533, 1927, 3692, 1983, 11891, 18, 3]}]}
{"query": {"id": "q_4804", "content": "dobutamine [SEP] c damage due to doxorubicin, a cohort study was performed using dobutamine infusion to differentiate asymptomatic long-term survivors of c", "tokenized_content": [2, 2608, 16119, 3812, 3, 45, 4293, 2810, 1942, 12377, 16, 43, 4382, 2161, 1982, 2593, 2193, 2608, 16119, 3812, 7386, 1942, 9290, 9978, 2815, 17, 2576, 9408, 1927, 45, 3]}, "items": [{"id": "p_4804", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_4805", "content": "cancer [SEP] Doxorubicin is an effective anticancer chemotherapeutic agent known to cause acute and chronic cardiom", "tokenized_content": [2, 2539, 3, 12377, 1977, 1925, 3655, 11515, 14124, 5899, 3171, 1942, 3936, 3939, 1930, 3724, 21129, 1035, 3]}, "items": [{"id": "p_4805", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4806", "content": "Dobutamine [SEP] rmed before infusion and after 15 min of infusion at each rate. Dobutamine infusion at 10 micrograms/kg per min was discontinued after six", "tokenized_content": [2, 2608, 16119, 3812, 3, 10625, 1919, 3119, 7386, 1930, 2256, 2461, 2360, 1927, 7386, 2019, 2362, 2769, 18, 2608, 16119, 3812, 7386, 2019, 2119, 13362, 19, 3621, 2079, 2360, 1982, 3]}, "items": [{"id": "p_4806", "content": "Dobutamine [SEP] A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CA", "score": 1, "type": null, "tokenized_content": [2, 2608, 16119, 3812, 3, 43, 23483, 10533, 1956, 4896, 1958, 4666, 17, 21, 13672, 4086, 18, 2176, 1977, 5384, 2251, 1966, 43, 21129, 24970, 5899, 2256, 2332, 3]}]}
{"query": {"id": "q_4807", "content": "aminophylline [SEP] Effects of aminophylline on the threshold for initiating ventricular fibrillation during", "tokenized_content": [2, 3835, 25818, 11560, 2053, 3, 2564, 1927, 3835, 25818, 11560, 2053, 1990, 1920, 4683, 1958, 12410, 6493, 13671, 2409, 3]}, "items": [{"id": "p_4807", "content": "Aminophylline [SEP] A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar", "score": 1, "type": null, "tokenized_content": [2, 3835, 25818, 11560, 2053, 3, 43, 2838, 3921, 1988, 5461, 29629, 1930, 26436, 3812, 18, 2176, 1977, 2253, 6622, 1922, 3224, 2254, 29629, 2308, 2258, 2551, 3]}]}
{"query": {"id": "q_4808", "content": "ventricular fibrillation [SEP] Effects of aminophylline on the threshold for initiating ventricular fibrillation during respiratory failure.", "tokenized_content": [2, 6493, 13671, 3, 2564, 1927, 3835, 25818, 11560, 2053, 1990, 1920, 4683, 1958, 12410, 6493, 13671, 2409, 5481, 4574, 18, 3]}, "items": [{"id": "p_4808", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_4809", "content": "respiratory failure [SEP] on the threshold for initiating ventricular fibrillation during respiratory failure.", "tokenized_content": [2, 5481, 4574, 3, 1990, 1920, 4683, 1958, 12410, 6493, 13671, 2409, 5481, 4574, 18, 3]}, "items": [{"id": "p_4809", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_4810", "content": "Cardiac arrhythmias [SEP] Cardiac arrhythmias have frequently been reported in association with respiratory f", "tokenized_content": [2, 4435, 16934, 3, 4435, 16934, 2162, 5467, 2252, 2568, 1922, 3279, 1956, 5481, 48, 3]}, "items": [{"id": "p_4810", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_4811", "content": "respiratory failure [SEP] c arrhythmias have frequently been reported in association with respiratory failure. The possible additive role of pharmacologic agents in precipit", "tokenized_content": [2, 5481, 4574, 3, 45, 16934, 2162, 5467, 2252, 2568, 1922, 3279, 1956, 5481, 4574, 18, 1920, 3216, 10359, 2770, 1927, 17225, 4820, 1922, 9637, 3]}, "items": [{"id": "p_4811", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_4812", "content": "cardiac disturbances [SEP] possible additive role of pharmacologic agents in precipitating cardiac disturbances in patients with respiratory failure has only recently been emp", "tokenized_content": [2, 4435, 12654, 3, 3216, 10359, 2770, 1927, 17225, 4820, 1922, 9637, 2287, 4435, 12654, 1922, 2132, 1956, 5481, 4574, 2258, 2444, 3998, 2252, 6467, 3]}, "items": [{"id": "p_4812", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_4813", "content": "aminophylline [SEP] atory failure has only recently been emphasized. The effects of aminophylline on the ventricular fibrillation threshold during normal acid-ba", "tokenized_content": [2, 3835, 25818, 11560, 2053, 3, 22973, 1012, 4574, 2258, 2444, 3998, 2252, 15028, 18, 1920, 2564, 1927, 3835, 25818, 11560, 2053, 1990, 1920, 6493, 13671, 4683, 2409, 2791, 2687, 17, 3]}, "items": [{"id": "p_4813", "content": "Aminophylline [SEP] A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar", "score": 1, "type": null, "tokenized_content": [2, 3835, 25818, 11560, 2053, 3, 43, 2838, 3921, 1988, 5461, 29629, 1930, 26436, 3812, 18, 2176, 1977, 2253, 6622, 1922, 3224, 2254, 29629, 2308, 2258, 2551, 3]}]}
{"query": {"id": "q_4814", "content": "ventricular fibrillation [SEP] y recently been emphasized. The effects of aminophylline on the ventricular fibrillation threshold during normal acid-base conditions and during respira", "tokenized_content": [2, 6493, 13671, 3, 67, 3998, 2252, 15028, 18, 1920, 2564, 1927, 3835, 25818, 11560, 2053, 1990, 1920, 6493, 13671, 4683, 2409, 2791, 2687, 17, 5170, 2961, 1930, 2409, 4962, 1019, 3]}, "items": [{"id": "p_4814", "content": "Ventricular Fibrillation [SEP] A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (40", "score": 1, "type": null, "tokenized_content": [2, 6493, 13671, 3, 43, 5063, 10470, 4435, 18346, 1988, 1977, 4378, 2007, 20732, 2538, 4597, 8113, 4052, 9700, 1927, 8287, 21896, 1036, 12, 3040, 3]}]}
{"query": {"id": "q_4815", "content": "oxygen [SEP] 0 to 40 percent of the control when pH and partial pressures of oxygen (PO2) and carbon dioxide (CO2) were kept within normal limits. ", "tokenized_content": [2, 4612, 3, 20, 1942, 3040, 3564, 1927, 1920, 2285, 2469, 2087, 1930, 5740, 11704, 1927, 4612, 12, 24139, 13, 1930, 5056, 15422, 12, 6333, 13, 1985, 8356, 2651, 2791, 8183, 3]}, "items": [{"id": "p_4815", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_4816", "content": "PO2 [SEP] percent of the control when pH and partial pressures of oxygen (PO2) and carbon dioxide (CO2) were kept within normal limits. When ", "tokenized_content": [2, 24139, 3, 3564, 1927, 1920, 2285, 2469, 2087, 1930, 5740, 11704, 1927, 4612, 12, 24139, 13, 1930, 5056, 15422, 12, 6333, 13, 1985, 8356, 2651, 2791, 8183, 18, 2469, 3]}, "items": [{"id": "p_4816", "content": "PO-2 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2510, 17, 22, 3, 3]}]}
{"query": {"id": "q_4817", "content": "carbon dioxide [SEP] f the control when pH and partial pressures of oxygen (PO2) and carbon dioxide (CO2) were kept within normal limits. When respiratory failure ", "tokenized_content": [2, 5056, 15422, 3, 48, 1920, 2285, 2469, 2087, 1930, 5740, 11704, 1927, 4612, 12, 24139, 13, 1930, 5056, 15422, 12, 6333, 13, 1985, 8356, 2651, 2791, 8183, 18, 2469, 5481, 3]}, "items": [{"id": "p_4817", "content": "Carbon Dioxide [SEP] A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5056, 15422, 3, 43, 29500, 16, 12685, 5427, 4422, 1988, 2112, 1998, 5333, 2007, 1920, 3362, 1930, 1977, 4680, 1958, 1920, 11695, 4048, 1927, 4793, 1930, 3555, 18, 3]}]}
{"query": {"id": "q_4818", "content": "CO2 [SEP] en pH and partial pressures of oxygen (PO2) and carbon dioxide (CO2) were kept within normal limits. When respiratory failure was p", "tokenized_content": [2, 6333, 3, 2066, 2087, 1930, 5740, 11704, 1927, 4612, 12, 24139, 13, 1930, 5056, 15422, 12, 6333, 13, 1985, 8356, 2651, 2791, 8183, 18, 2469, 5481, 4574, 1982, 58, 3]}, "items": [{"id": "p_4818", "content": "Carbon Dioxide [SEP] A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5056, 15422, 3, 43, 29500, 16, 12685, 5427, 4422, 1988, 2112, 1998, 5333, 2007, 1920, 3362, 1930, 1977, 4680, 1958, 1920, 11695, 4048, 1927, 4793, 1930, 3555, 18, 3]}]}
{"query": {"id": "q_4819", "content": "hypoventilation [SEP]  within normal limits. When respiratory failure was produced by hypoventilation (pH 7.05 to 7.25; PC02 70 to 100 mm Hg: P02 20 to 40 mm Hg), in", "tokenized_content": [2, 14395, 5954, 29526, 3, 2651, 2791, 8183, 18, 2469, 5481, 4574, 1982, 4152, 2007, 14395, 5954, 29526, 12, 2087, 27, 18, 2914, 1942, 27, 18, 2637, 31, 3808, 11636, 3895, 3]}, "items": [{"id": "p_4819", "content": "Hypoventilation [SEP] A reduction in the amount of air entering the pulmonary alveoli.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14395, 5954, 29526, 3, 43, 3378, 1922, 1920, 4351, 1927, 4433, 14657, 1920, 5352, 23405, 8436, 18, 3]}]}
{"query": {"id": "q_4820", "content": "ventricular arrhythmias [SEP] hough many factors may contribute to the increased incidence of ventricular arrhythmias in respiratory failure, pharmacologic agents, particularly amin", "tokenized_content": [2, 6493, 16934, 3, 6673, 2491, 3086, 2790, 2278, 4672, 1942, 1920, 2502, 4332, 1927, 6493, 16934, 1922, 5481, 4574, 16, 17225, 4820, 16, 4443, 8584, 3]}, "items": [{"id": "p_4820", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_4821", "content": "carbachol [SEP] Case report: acute unintentional carbachol intoxication.", "tokenized_content": [2, 28940, 3, 3087, 3809, 30, 3939, 18191, 5307, 28940, 20965, 18, 3]}, "items": [{"id": "p_4821", "content": "Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28940, 3, 43, 11240, 21665, 13908, 7829, 1988, 8016, 2019, 2321, 20318, 1930, 20239, 4086, 18, 3]}]}
{"query": {"id": "q_4822", "content": "carbachol [SEP] INTRODUCTION: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report ", "tokenized_content": [2, 28940, 3, 6935, 30, 20965, 1036, 1956, 28940, 16, 43, 20318, 13908, 3148, 7829, 2032, 5844, 18, 2038, 3809, 3]}, "items": [{"id": "p_4822", "content": "Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28940, 3, 43, 11240, 21665, 13908, 7829, 1988, 8016, 2019, 2321, 20318, 1930, 20239, 4086, 18, 3]}]}
{"query": {"id": "q_4823", "content": "poisoning [SEP] are. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper", "tokenized_content": [2, 18722, 3, 2032, 18, 2038, 3809, 1925, 4228, 3087, 9651, 43, 12, 4931, 13, 11990, 18722, 18, 2860, 30, 1920, 9337, 1927, 1925, 5686, 17, 2476, 17, 4156, 4005, 8117, 3]}, "items": [{"id": "p_4823", "content": "Poisoning [SEP] A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18722, 3, 43, 2625, 2014, 3841, 3360, 4152, 2007, 1920, 14195, 16, 4107, 16, 14728, 1927, 2014, 3395, 1942, 43, 12524, 5899, 18, 3]}]}
{"query": {"id": "q_4824", "content": "Alzheimer's disease [SEP] ewspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the sy", "tokenized_content": [2, 9116, 11, 61, 2573, 3, 27739, 4302, 2116, 3809, 10838, 1029, 2535, 3811, 1956, 4496, 6391, 1922, 9116, 11, 61, 2573, 18, 1920, 5754, 1927, 4615, 1982, 12029, 1942, 1998, 3]}, "items": [{"id": "p_4824", "content": "Alzheimer Disease [SEP] A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention ", "score": 1, "type": null, "tokenized_content": [2, 9116, 2573, 3, 43, 15676, 2573, 1927, 1920, 3068, 4378, 2007, 1920, 2346, 13756, 2080, 4727, 1927, 7811, 18, 6159, 1927, 4525, 16, 17449, 16, 4976, 3]}]}
{"query": {"id": "q_4825", "content": "carbamylcholin [SEP] on was said to be comparable to that of the synthetic compound 'carbamylcholin'; that is, carbachol. He bought 25 g of carbachol as pure subst", "tokenized_content": [2, 17742, 2199, 22513, 1921, 3, 1990, 1982, 12029, 1942, 1998, 5596, 1942, 1988, 1927, 1920, 6830, 3547, 11, 17742, 2199, 22513, 1921, 11, 31, 1988, 1977, 16, 28940, 18, 2234, 3]}, "items": [{"id": "p_4825", "content": "Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28940, 3, 43, 11240, 21665, 13908, 7829, 1988, 8016, 2019, 2321, 20318, 1930, 20239, 4086, 18, 3]}]}
{"query": {"id": "q_4826", "content": "Carbachol [SEP] e in a pharmacy, and the father was administered 400 to 500 mg. Carbachol concentrations in serum and urine on day 1 and 2 of hospital ad", "tokenized_content": [2, 28940, 3, 47, 1922, 43, 14429, 16, 1930, 1920, 14854, 1982, 5254, 5805, 1942, 4599, 2786, 18, 28940, 3295, 1922, 3256, 1930, 6960, 1990, 3007, 21, 1930, 22, 1927, 3461, 3]}, "items": [{"id": "p_4826", "content": "Carbachol [SEP] A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 28940, 3, 43, 11240, 21665, 13908, 7829, 1988, 8016, 2019, 2321, 20318, 1930, 20239, 4086, 18, 3]}]}
{"query": {"id": "q_4827", "content": "nausea [SEP] SULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, ", "tokenized_content": [2, 13759, 3, 9596, 1973, 30, 4814, 2256, 4726, 4183, 16, 1920, 2774, 3530, 13759, 16, 25386, 1941, 1930, 16453, 16, 1930, 4342, 20469, 18, 26192, 16, 3]}, "items": [{"id": "p_4827", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_4828", "content": "hypotension [SEP] oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and a", "tokenized_content": [2, 16453, 3, 4726, 4183, 16, 1920, 2774, 3530, 13759, 16, 25386, 1941, 1930, 16453, 16, 1930, 4342, 20469, 18, 26192, 16, 13908, 3601, 1930, 43, 3]}, "items": [{"id": "p_4828", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4829", "content": "Bradycardia [SEP] eloped nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulm", "tokenized_content": [2, 26192, 3, 2349, 4907, 1007, 13759, 16, 25386, 1941, 1930, 16453, 16, 1930, 4342, 20469, 18, 26192, 16, 13908, 3601, 1930, 1966, 2298, 2456, 4807, 18, 3754, 21129, 1034, 1944, 3]}, "items": [{"id": "p_4829", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_4830", "content": "asystole [SEP] n, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate t", "tokenized_content": [2, 1966, 2298, 2456, 3, 56, 16, 1930, 4342, 20469, 18, 26192, 16, 13908, 3601, 1930, 1966, 2298, 2456, 4807, 18, 3754, 17749, 15371, 1930, 8426, 62, 3]}, "items": [{"id": "p_4830", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_4831", "content": "adrenaline [SEP] tial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospi", "tokenized_content": [2, 10651, 2053, 3, 22093, 1024, 17749, 15371, 1930, 8426, 2311, 1956, 10651, 2053, 12, 19280, 13, 16, 24031, 1930, 30509, 1982, 4654, 18, 1990, 3219, 1033, 3]}, "items": [{"id": "p_4831", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_4832", "content": "epinephrine [SEP] ulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission", "tokenized_content": [2, 19280, 3, 3570, 5053, 15371, 1930, 8426, 2311, 1956, 10651, 2053, 12, 19280, 13, 16, 24031, 1930, 30509, 1982, 4654, 18, 1990, 3461, 7682, 3]}, "items": [{"id": "p_4832", "content": "Epinephrine [SEP] The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes ", "score": 1, "type": null, "tokenized_content": [2, 19280, 3, 1920, 3500, 26638, 1947, 21870, 6365, 2037, 1920, 10651, 18755, 18, 2176, 11803, 2321, 1920, 4595, 17, 1930, 4666, 17, 13672, 3771, 16, 5092, 3]}]}
{"query": {"id": "q_4833", "content": "atropine [SEP] citation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pre", "tokenized_content": [2, 24031, 3, 21083, 1930, 8426, 2311, 1956, 10651, 2053, 12, 19280, 13, 16, 24031, 1930, 30509, 1982, 4654, 18, 1990, 3461, 7682, 16, 2877, 2097, 3]}, "items": [{"id": "p_4833", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_4834", "content": "furosemide [SEP] immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the in", "tokenized_content": [2, 30509, 3, 8426, 2311, 1956, 10651, 2053, 12, 19280, 13, 16, 24031, 1930, 30509, 1982, 4654, 18, 1990, 3461, 7682, 16, 2877, 3772, 1927, 1920, 1922, 3]}, "items": [{"id": "p_4834", "content": "Furosemide [SEP] A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFF", "score": 1, "type": null, "tokenized_content": [2, 30509, 3, 43, 19225, 1935, 17, 26265, 5482, 17, 28028, 1022, 18, 2176, 1977, 43, 26829, 1956, 5867, 4727, 1930, 3662, 4392, 1988, 1977, 2251, 1958, 10144, 1930, 3724, 4604, 7697, 2040, 3]}]}
{"query": {"id": "q_4835", "content": "hyperhidrosis [SEP] ed, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electro", "tokenized_content": [2, 4194, 7969, 3883, 2475, 3, 3347, 16, 20152, 23246, 4913, 2774, 1982, 2813, 19, 4459, 9348, 18, 2520, 6879, 1985, 4194, 7969, 3883, 2475, 16, 10694, 12498, 9664, 16, 7777, 3]}, "items": [{"id": "p_4835", "content": "Hyperhidrosis [SEP] Excessive sweating. In the localized type, the most frequent sites are the palms, soles, axillae, inguinal folds, and the perine", "score": 1, "type": null, "tokenized_content": [2, 4194, 7969, 3883, 2475, 3, 9122, 25386, 1941, 18, 1922, 1920, 6579, 2601, 16, 1920, 2501, 6439, 3402, 2032, 1920, 15516, 1036, 16, 12168, 1036, 16, 19911, 11560, 3336, 16, 19820, 16231, 16, 1930, 1920, 20238, 3]}]}
{"query": {"id": "q_4836", "content": "hypersalivation [SEP] hmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic fin", "tokenized_content": [2, 10694, 12498, 9664, 3, 5833, 1935, 2774, 1982, 2813, 19, 4459, 9348, 18, 2520, 6879, 1985, 4194, 7969, 3883, 2475, 16, 10694, 12498, 9664, 16, 7777, 6990, 6802, 1019, 16, 3]}, "items": [{"id": "p_4836", "content": "Sialorrhea [SEP] Increased salivary flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 12952, 21588, 3, 2502, 11866, 3426, 18, 3]}]}
{"query": {"id": "q_4837", "content": "miosis [SEP]  were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissoci", "tokenized_content": [2, 6519, 2475, 3, 1985, 4194, 7969, 3883, 2475, 16, 10694, 12498, 9664, 16, 7777, 6990, 6802, 1019, 16, 1930, 4010, 6519, 2475, 31, 1920, 15894, 4158, 2849, 1982, 26500, 1037, 3]}, "items": [{"id": "p_4837", "content": "Miosis [SEP] Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innerva", "score": 1, "type": null, "tokenized_content": [2, 6519, 2475, 3, 19878, 5148, 6907, 19837, 18, 2052, 2278, 3211, 2037, 9901, 3905, 1927, 1920, 4333, 5499, 2684, 19878, 5148, 6907, 3760, 16, 9785, 11739, 21768, 1019, 3]}]}
{"query": {"id": "q_4838", "content": "atrio-ventricular dissociation [SEP] rrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline ", "tokenized_content": [2, 26500, 1037, 17, 6493, 9182, 3, 5162, 10647, 5376, 16, 1930, 4010, 6519, 2475, 31, 1920, 15894, 4158, 2849, 1982, 26500, 1037, 17, 6493, 9182, 18, 2149, 5312, 1927, 24031, 3]}, "items": [{"id": "p_4838", "content": "Heart Block [SEP] Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE", "score": 1, "type": null, "tokenized_content": [2, 4003, 3367, 3, 5761, 12382, 1927, 4435, 21896, 1988, 2112, 4704, 2967, 26264, 4231, 1920, 12382, 3374, 16, 2427, 1966, 2192, 1920, 3132, 6952, 17075, 6267, 3]}]}
{"query": {"id": "q_4839", "content": "dopamine [SEP] gh doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However", "tokenized_content": [2, 7964, 3, 6101, 5312, 1927, 24031, 12, 2353, 1942, 2761, 2786, 2079, 2686, 3967, 13, 16, 10651, 2053, 1930, 7964, 1985, 4680, 18, 1920, 2774, 1982, 2897, 17873, 21, 2982, 3]}, "items": [{"id": "p_4839", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_4840", "content": "dyspnoea [SEP] ary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insuffi", "tokenized_content": [2, 14633, 26447, 3, 2245, 1012, 18, 1920, 2774, 1982, 2897, 17873, 21, 2982, 3690, 18, 2406, 16, 2502, 14633, 26447, 1930, 7777, 26544, 16593, 1981, 27219, 11974, 18, 5481, 7697, 3]}, "items": [{"id": "p_4840", "content": "Dyspnea [SEP] Difficult or labored breathing.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18461, 3, 4571, 2014, 3876, 1919, 11995, 18, 3]}]}
{"query": {"id": "q_4841", "content": "bronchospasm [SEP] ent was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was furthe", "tokenized_content": [2, 7777, 26544, 3, 8496, 1982, 2897, 17873, 21, 2982, 3690, 18, 2406, 16, 2502, 14633, 26447, 1930, 7777, 26544, 16593, 1981, 27219, 11974, 18, 5481, 14566, 1982, 2498, 20536, 3]}, "items": [{"id": "p_4841", "content": "Bronchial Spasm [SEP] Spasmodic contraction of the smooth muscle of the bronchi.\n    ", "score": 1, "type": null, "tokenized_content": [2, 14700, 24431, 3, 24431, 12486, 8332, 1927, 1920, 6689, 3760, 1927, 1920, 20431, 18, 3]}]}
{"query": {"id": "q_4842", "content": "Respiratory insufficiency [SEP]  increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe ", "tokenized_content": [2, 5481, 14566, 3, 2502, 14633, 26447, 1930, 7777, 26544, 16593, 1981, 27219, 11974, 18, 5481, 14566, 1982, 2520, 22784, 2007, 2174, 1957, 3138, 3836, 1937, 2909, 1930, 4010, 3]}, "items": [{"id": "p_4842", "content": "Respiratory Insufficiency [SEP] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 5481, 14566, 3, 4574, 1942, 13498, 3394, 4612, 1942, 2094, 1927, 1920, 3362, 1930, 1942, 7989, 5799, 5056, 15422, 2037, 3581, 18, 12, 4780, 6366, 1928, 16, 23524, 3347, 13, 3]}]}
{"query": {"id": "q_4843", "content": "Proteus mirabilis infection [SEP] reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was", "tokenized_content": [2, 2174, 1957, 3138, 3836, 1937, 2909, 3, 27219, 11974, 18, 5481, 14566, 1982, 2520, 22784, 2007, 2174, 1957, 3138, 3836, 1937, 2909, 1930, 4010, 7777, 15975, 7487, 18, 2340, 2982, 3]}, "items": [{"id": "p_4843", "content": "Proteus Infections [SEP] Infections with bacteria of the genus PROTEUS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2174, 1957, 5024, 3, 5024, 1956, 4802, 1927, 1920, 9487, 2174, 1957, 18, 3]}]}
{"query": {"id": "q_4844", "content": "heart failure [SEP] ripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and", "tokenized_content": [2, 4003, 4574, 3, 8936, 2380, 1923, 14125, 18, 1990, 1920, 4560, 3007, 2234, 8545, 16, 6226, 1966, 43, 3211, 1927, 4003, 4574, 18, 3256, 2785, 2037, 1920, 2561, 1930, 2812, 3]}, "items": [{"id": "p_4844", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4845", "content": "acute cardiovascular failure [SEP] should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure.", "tokenized_content": [2, 3939, 5321, 4574, 3, 3066, 2782, 20965, 1036, 12, 1956, 13908, 1036, 13, 1966, 43, 3936, 1927, 3939, 5321, 4574, 18, 3]}, "items": [{"id": "p_4845", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4846", "content": "rizatriptan [SEP] Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine.", "tokenized_content": [2, 11280, 12813, 1997, 14302, 1928, 3, 15845, 3723, 1927, 4348, 1930, 8308, 1958, 11280, 12813, 1997, 14302, 1928, 2119, 2786, 4072, 11949, 7336, 25157, 19, 14119, 1922, 13258, 18, 3]}, "items": [{"id": "p_4846", "content": "rizatriptan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11280, 12813, 1997, 14302, 1928, 3, 3]}]}
{"query": {"id": "q_4847", "content": "ergotamine [SEP] parison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine.", "tokenized_content": [2, 11949, 7336, 25157, 3, 21636, 1916, 1927, 4348, 1930, 8308, 1958, 11280, 12813, 1997, 14302, 1928, 2119, 2786, 4072, 11949, 7336, 25157, 19, 14119, 1922, 13258, 18, 3]}, "items": [{"id": "p_4847", "content": "Ergotamine [SEP] A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the", "score": 1, "type": null, "tokenized_content": [2, 11949, 7336, 25157, 3, 43, 28404, 2684, 2435, 1922, 11949, 1991, 1927, 4101, 5560, 18, 2176, 1977, 43, 11153, 7829, 1988, 2258, 2252, 2251, 1966, 1925, 16462, 19977, 5899, 1930, 1922, 1920, 3]}]}
{"query": {"id": "q_4848", "content": "caffeine [SEP] efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine.", "tokenized_content": [2, 14119, 3, 4348, 1930, 8308, 1958, 11280, 12813, 1997, 14302, 1928, 2119, 2786, 4072, 11949, 7336, 25157, 19, 14119, 1922, 13258, 18, 3]}, "items": [{"id": "p_4848", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_4849", "content": "migraine [SEP]  preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine.", "tokenized_content": [2, 13258, 3, 8308, 1958, 11280, 12813, 1997, 14302, 1928, 2119, 2786, 4072, 11949, 7336, 25157, 19, 14119, 1922, 13258, 18, 3]}, "items": [{"id": "p_4849", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_4850", "content": "Rizatriptan [SEP] Rizatriptan is a selective 5-HT(1B/1D) receptor agonist with rapid oral abs", "tokenized_content": [2, 11280, 12813, 1997, 14302, 1928, 3, 11280, 12813, 1997, 14302, 1928, 1977, 43, 5328, 25, 17, 5334, 12, 5462, 19, 8046, 13, 3148, 7829, 1956, 4052, 4726, 2872, 3]}, "items": [{"id": "p_4850", "content": "rizatriptan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11280, 12813, 1997, 14302, 1928, 3, 3]}]}
{"query": {"id": "q_4851", "content": "5-HT [SEP] Rizatriptan is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and early on", "tokenized_content": [2, 25, 17, 5334, 3, 11280, 12813, 1997, 14302, 1928, 1977, 43, 5328, 25, 17, 5334, 12, 5462, 19, 8046, 13, 3148, 7829, 1956, 4052, 4726, 6726, 1930, 3120, 1990, 3]}, "items": [{"id": "p_4851", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_4852", "content": "migraine [SEP]  absorption and early onset of action in the acute treatment of migraine. This randomized double- blind crossover outpatient study asses", "tokenized_content": [2, 13258, 3, 6726, 1930, 3120, 4727, 1927, 4615, 1922, 1920, 3939, 2311, 1927, 13258, 18, 2052, 5542, 4825, 17, 7109, 15845, 10037, 2161, 2088, 1918, 3]}, "items": [{"id": "p_4852", "content": "Migraine Disorders [SEP] A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtyp", "score": 1, "type": null, "tokenized_content": [2, 13258, 4414, 3, 43, 2921, 1927, 27606, 3065, 12187, 4414, 16, 4378, 2007, 7457, 12059, 25960, 24339, 18, 1920, 2288, 3044, 6008, 3]}]}
{"query": {"id": "q_4853", "content": "rizatriptan [SEP]  blind crossover outpatient study assessed the preference for 1 rizatriptan 10 mg tablet to 2 ergotamine 1 mg/caffeine 100 mg tablets in 43", "tokenized_content": [2, 11280, 12813, 1997, 14302, 1928, 3, 7109, 15845, 10037, 2161, 3683, 1920, 8308, 1958, 21, 11280, 12813, 1997, 14302, 1928, 2119, 2786, 17127, 1942, 22, 11949, 7336, 25157, 21, 2786, 3]}, "items": [{"id": "p_4853", "content": "rizatriptan [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 11280, 12813, 1997, 14302, 1928, 3, 3]}]}
{"query": {"id": "q_4854", "content": "ergotamine [SEP] udy assessed the preference for 1 rizatriptan 10 mg tablet to 2 ergotamine 1 mg/caffeine 100 mg tablets in 439 patients treating a single ", "tokenized_content": [2, 11949, 7336, 25157, 3, 19803, 1012, 3683, 1920, 8308, 1958, 21, 11280, 12813, 1997, 14302, 1928, 2119, 2786, 17127, 1942, 22, 11949, 7336, 25157, 21, 2786, 19, 14119, 2813, 2786, 3]}, "items": [{"id": "p_4854", "content": "Ergotamine [SEP] A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the", "score": 1, "type": null, "tokenized_content": [2, 11949, 7336, 25157, 3, 43, 28404, 2684, 2435, 1922, 11949, 1991, 1927, 4101, 5560, 18, 2176, 1977, 43, 11153, 7829, 1988, 2258, 2252, 2251, 1966, 1925, 16462, 19977, 5899, 1930, 1922, 1920, 3]}]}
{"query": {"id": "q_4855", "content": "caffeine [SEP]  preference for 1 rizatriptan 10 mg tablet to 2 ergotamine 1 mg/caffeine 100 mg tablets in 439 patients treating a single migraine attac", "tokenized_content": [2, 14119, 3, 8308, 1958, 21, 11280, 12813, 1997, 14302, 1928, 2119, 2786, 17127, 1942, 22, 11949, 7336, 25157, 21, 2786, 19, 14119, 2813, 2786, 16576, 1922, 3941, 1026, 2132, 8247, 3]}, "items": [{"id": "p_4855", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_4856", "content": "headache [SEP] ine/caffeine (69.9 vs. 30.1%, p < or = 0.001). Faster relief of headache was the most important reason for preference, cited by 67.3% of", "tokenized_content": [2, 12187, 3, 11116, 19, 14119, 12, 5349, 18, 29, 3201, 18, 2627, 18, 21, 9, 16, 58, 32, 2014, 33, 20, 18, 3472, 13, 18, 8411, 13104, 1927, 12187, 1982, 3]}, "items": [{"id": "p_4856", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_4857", "content": "pain [SEP] preferred ergotamine/caffeine. The co-primary endpoint of being pain free at 2 h was also in favor of rizatriptan. Forty-nine percen", "tokenized_content": [2, 3594, 3, 8579, 11949, 7336, 25157, 19, 14119, 18, 1920, 2081, 17, 3065, 11857, 1927, 3301, 3594, 3294, 2019, 22, 50, 1982, 2222, 1922, 7197, 1927, 11280, 12813, 1997, 14302, 3]}, "items": [{"id": "p_4857", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4858", "content": "Headache [SEP] r = 0.001), rizatriptan being superior within 1 h of treatment. Headache relief at 2 h was 75.9% for rizatriptan and 47.3% for ergotamin", "tokenized_content": [2, 12187, 3, 60, 33, 20, 18, 3472, 13, 16, 11280, 12813, 1997, 14302, 1928, 3301, 6566, 2651, 21, 50, 1927, 2311, 18, 12187, 13104, 2019, 22, 50, 1982, 4089, 18, 3]}, "items": [{"id": "p_4858", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_4859", "content": "nausea [SEP] r to ergotamine/caffeine in the proportions of patients with no nausea, vomiting, phonophobia or photophobia and for patients with nor", "tokenized_content": [2, 13759, 3, 60, 1942, 11949, 7336, 25157, 19, 14119, 1922, 1920, 9766, 1927, 2132, 1956, 2239, 13759, 16, 13954, 16, 11999, 2688, 18311, 2014, 10066, 2102, 18311, 1930, 1958, 2132, 3]}, "items": [{"id": "p_4859", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_4860", "content": "vomiting [SEP] otamine/caffeine in the proportions of patients with no nausea, vomiting, phonophobia or photophobia and for patients with normal functi", "tokenized_content": [2, 13954, 3, 28495, 25157, 19, 14119, 1922, 1920, 9766, 1927, 2132, 1956, 2239, 13759, 16, 13954, 16, 11999, 2688, 18311, 2014, 10066, 2102, 18311, 1930, 1958, 2132, 1956, 2791, 2277, 3]}, "items": [{"id": "p_4860", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_4861", "content": "phonophobia [SEP] ffeine in the proportions of patients with no nausea, vomiting, phonophobia or photophobia and for patients with normal function 2 h after ", "tokenized_content": [2, 11999, 2688, 18311, 3, 10735, 14818, 1021, 1922, 1920, 9766, 1927, 2132, 1956, 2239, 13759, 16, 13954, 16, 11999, 2688, 18311, 2014, 10066, 2102, 18311, 1930, 1958, 2132, 1956, 2791, 3]}, "items": [{"id": "p_4861", "content": "Hyperacusis [SEP] An abnormally disproportionate increase in the sensation of loudness in response to auditory stimuli of normal volume. COCHLEAR ", "score": 1, "type": null, "tokenized_content": [2, 4194, 1948, 24327, 1036, 3, 1925, 20756, 30106, 2760, 1922, 1920, 15826, 1927, 23954, 2971, 1922, 2644, 1942, 8401, 5458, 1927, 2791, 3776, 18, 15865, 3]}]}
{"query": {"id": "q_4862", "content": "photophobia [SEP] roportions of patients with no nausea, vomiting, phonophobia or photophobia and for patients with normal function 2 h after drug intake (p ", "tokenized_content": [2, 10066, 2102, 18311, 3, 17890, 2718, 2443, 1927, 2132, 1956, 2239, 13759, 16, 13954, 16, 11999, 2688, 18311, 2014, 10066, 2102, 18311, 1930, 1958, 2132, 1956, 2791, 2347, 22, 50, 3]}, "items": [{"id": "p_4862", "content": "Photophobia [SEP] Abnormal sensitivity to light. This may occur as a manifestation of EYE DISEASES; MIGRAINE; SUBARACHNOID HEMORRHAGE; MENINGITIS;", "score": 1, "type": null, "tokenized_content": [2, 10066, 2102, 18311, 3, 4552, 3802, 1942, 3696, 18, 2052, 2278, 4704, 1966, 43, 15570, 1927, 5723, 3902, 31, 13258, 31, 23795, 10489, 31, 16780, 31, 3]}]}
{"query": {"id": "q_4863", "content": "dizziness [SEP] ) after rizatriptan and ergotamine/caffeine, respectively, were dizziness (6.7 and 5.3%), nausea (4.2 and 8.5%) and somnolence (5.5 and 2", "tokenized_content": [2, 24009, 3, 13, 2256, 11280, 12813, 1997, 14302, 1928, 1930, 11949, 7336, 25157, 19, 14119, 16, 2763, 16, 1985, 24009, 12, 26, 18, 27, 1930, 25, 18, 23, 9, 13, 3]}, "items": [{"id": "p_4863", "content": "Dizziness [SEP] An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24009, 3, 1925, 26385, 2870, 2576, 2154, 2278, 3333, 1942, 43, 7534, 1927, 5067, 2054, 29292, 16, 6269, 1927, 1920, 3515, 16, 2014, 3696, 10611, 1919, 2971, 18, 3]}]}
{"query": {"id": "q_4864", "content": "somnolence [SEP] ively, were dizziness (6.7 and 5.3%), nausea (4.2 and 8.5%) and somnolence (5.5 and 2.3%).", "tokenized_content": [2, 5714, 11873, 15253, 1972, 3, 4370, 2264, 16, 1985, 24009, 12, 26, 18, 27, 1930, 25, 18, 23, 9, 13, 16, 13759, 12, 24, 18, 22, 1930, 28, 18, 25, 3]}, "items": [{"id": "p_4864", "content": "Disorders of Excessive Somnolence [SEP] Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include pr", "score": 1, "type": null, "tokenized_content": [2, 4414, 1927, 9122, 5714, 11873, 15253, 1972, 3, 4414, 4378, 2007, 10694, 29067, 2456, 15895, 1021, 2409, 2791, 26830, 3967, 1988, 2278, 3960, 4328, 7295, 18, 8160, 3951, 2033, 3]}]}
{"query": {"id": "q_4865", "content": "Thrombotic microangiopathy [SEP] Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy.", "tokenized_content": [2, 21039, 2703, 9506, 6522, 3, 21039, 2703, 9506, 6522, 1930, 4604, 4574, 2458, 1956, 29128, 9969, 5318, 18, 3]}, "items": [{"id": "p_4865", "content": "Thrombotic Microangiopathies [SEP] Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC", "score": 1, "type": null, "tokenized_content": [2, 21039, 2703, 9506, 16038, 3, 3902, 1988, 3211, 1922, 11354, 1922, 14264, 27795, 18, 1920, 2288, 2501, 8753, 3902, 2032, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3]}]}
{"query": {"id": "q_4866", "content": "renal failure [SEP] Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy.", "tokenized_content": [2, 4604, 4574, 3, 21039, 2703, 9506, 6522, 1930, 4604, 4574, 2458, 1956, 29128, 9969, 5318, 18, 3]}, "items": [{"id": "p_4866", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4867", "content": "carcinoma [SEP] Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal in", "tokenized_content": [2, 5373, 3, 3628, 2132, 1956, 5373, 3530, 21039, 2703, 9506, 6522, 12, 4378, 2007, 4604, 1922, 3]}, "items": [{"id": "p_4867", "content": "Carcinoma [SEP] A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It i", "score": 1, "type": null, "tokenized_content": [2, 5373, 3, 43, 6558, 12132, 3915, 2353, 1927, 4944, 2094, 5370, 1941, 1942, 19155, 1920, 7510, 3878, 1930, 7031, 7164, 1942, 8174, 18, 2176, 51, 3]}]}
{"query": {"id": "q_4868", "content": "thrombotic microangiopathy [SEP] Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolyt", "tokenized_content": [2, 21039, 2703, 9506, 6522, 3, 3628, 2132, 1956, 5373, 3530, 21039, 2703, 9506, 6522, 12, 4378, 2007, 4604, 14566, 16, 2703, 9506, 10982, 3243, 26558, 1031, 3]}, "items": [{"id": "p_4868", "content": "Thrombotic Microangiopathies [SEP] Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC", "score": 1, "type": null, "tokenized_content": [2, 21039, 2703, 9506, 16038, 3, 3902, 1988, 3211, 1922, 11354, 1922, 14264, 27795, 18, 1920, 2288, 2501, 8753, 3902, 2032, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3]}]}
{"query": {"id": "q_4869", "content": "renal insufficiency [SEP] arcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopeni", "tokenized_content": [2, 4604, 14566, 3, 9952, 3522, 3368, 3530, 21039, 2703, 9506, 6522, 12, 4378, 2007, 4604, 14566, 16, 2703, 9506, 10982, 21515, 10679, 16, 1930, 5394, 15864, 4907, 8635, 3]}, "items": [{"id": "p_4869", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4870", "content": "microangiopathic hemolytic anemia [SEP] rombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, ", "tokenized_content": [2, 2703, 9506, 10982, 21515, 10679, 3, 15612, 4627, 2002, 2703, 9506, 6522, 12, 4378, 2007, 4604, 14566, 16, 2703, 9506, 10982, 21515, 10679, 16, 1930, 5394, 17100, 13, 2256, 2311, 3]}, "items": [{"id": "p_4870", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_4871", "content": "thrombocytopenia [SEP] l insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a vinca alkaloi", "tokenized_content": [2, 17100, 3, 54, 14566, 16, 2703, 9506, 10982, 21515, 10679, 16, 1930, 5394, 17100, 13, 2256, 2311, 1956, 9284, 16, 23004, 16, 1930, 43, 24198, 1019, 14961, 26822, 3]}, "items": [{"id": "p_4871", "content": "Thrombocytopenia [SEP] A subnormal level of BLOOD PLATELETS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17100, 3, 43, 28843, 2620, 2237, 1927, 2877, 10097, 18, 3]}]}
{"query": {"id": "q_4872", "content": "cisplatin [SEP] ytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a vinca alkaloid. One patient had thrombotic th", "tokenized_content": [2, 9284, 3, 24412, 1935, 10679, 16, 1930, 5394, 17100, 13, 2256, 2311, 1956, 9284, 16, 23004, 16, 1930, 43, 24198, 1019, 29951, 18, 2340, 2774, 2430, 21039, 1913, 3]}, "items": [{"id": "p_4872", "content": "Cisplatin [SEP] An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and inter", "score": 1, "type": null, "tokenized_content": [2, 9284, 3, 1925, 13849, 1930, 3224, 17, 6622, 13299, 2796, 18, 2256, 7258, 9128, 16, 2176, 23943, 1956, 2678, 1942, 5074, 2321, 5153, 1930, 2107, 3]}]}
{"query": {"id": "q_4873", "content": "bleomycin [SEP] , and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a vinca alkaloid. One patient had thrombotic thrombocytope", "tokenized_content": [2, 23004, 3, 16, 1930, 5394, 17100, 13, 2256, 2311, 1956, 9284, 16, 23004, 16, 1930, 43, 24198, 1019, 29951, 18, 2340, 2774, 2430, 21039, 15864, 4907, 3]}, "items": [{"id": "p_4873", "content": "Bleomycin [SEP] A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA m", "score": 1, "type": null, "tokenized_content": [2, 23004, 3, 43, 2796, 1927, 2712, 8821, 8253, 7560, 2037, 22874, 3566, 2002, 8898, 7600, 1927, 23004, 8595, 1930, 11054, 18, 2176, 7042, 2678, 55, 3]}]}
{"query": {"id": "q_4874", "content": "vinca alkaloid [SEP] ombocytopenia) after treatment with cisplatin, bleomycin, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the", "tokenized_content": [2, 24198, 1019, 29951, 3, 7254, 4627, 27932, 12903, 13, 2256, 2311, 1956, 9284, 16, 23004, 16, 1930, 43, 24198, 1019, 29951, 18, 2340, 2774, 2430, 21039, 15864, 4907, 19730, 25945, 3]}, "items": [{"id": "p_4874", "content": "Vinca Alkaloids [SEP] A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TU", "score": 1, "type": null, "tokenized_content": [2, 24198, 1019, 22390, 3, 43, 2210, 1927, 18050, 17, 22164, 2053, 13351, 2154, 2032, 22390, 2926, 2037, 1920, 24198, 1019, 9487, 1927, 4793, 18, 2611, 2875, 11486, 1927, 9037, 3]}]}
{"query": {"id": "q_4875", "content": "thrombotic thrombocytopenic purpura [SEP] ith cisplatin, bleomycin, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme", "tokenized_content": [2, 21039, 15864, 4907, 19730, 25945, 9280, 3, 24737, 9284, 16, 23004, 16, 1930, 43, 24198, 1019, 29951, 18, 2340, 2774, 2430, 21039, 15864, 4907, 19730, 25945, 9280, 16, 2559, 1920, 3]}, "items": [{"id": "p_4875", "content": "Purpura, Thrombotic Thrombocytopenic [SEP] An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillar", "score": 1, "type": null, "tokenized_content": [2, 25945, 9280, 16, 21039, 15864, 4907, 19730, 3, 1925, 5815, 16, 9901, 16, 2014, 11444, 4770, 4189, 2007, 7163, 7883, 1956, 11354, 1922, 4262, 24332, 1930, 16139, 1933, 3]}]}
{"query": {"id": "q_4876", "content": "hemolytic-uremic syndrome [SEP]  One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Hi", "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 2340, 2774, 2430, 21039, 15864, 4907, 19730, 25945, 9280, 16, 2559, 1920, 21515, 17, 29870, 4741, 16, 1930, 2340, 1925, 6273, 2386, 1021, 25253, 2156, 3]}, "items": [{"id": "p_4876", "content": "Hemolytic-Uremic Syndrome [SEP] A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by", "score": 1, "type": null, "tokenized_content": [2, 21515, 17, 29870, 4741, 3, 43, 4741, 1988, 1977, 2458, 1956, 13943, 3902, 1927, 1920, 5245, 16, 2427, 1966, 4604, 5586, 7476, 18, 2176, 1977, 4378, 2007, 3]}]}
{"query": {"id": "q_4877", "content": "intravascular coagulation [SEP] . Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomer", "tokenized_content": [2, 19871, 12441, 3, 18, 12434, 4981, 1927, 1920, 4604, 2960, 2594, 3095, 1927, 19871, 12441, 16, 5985, 7359, 1920, 2858, 9345, 16, 24332, 16, 1930, 8778, 3]}, "items": [{"id": "p_4877", "content": "Disseminated Intravascular Coagulation [SEP] A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The ", "score": 1, "type": null, "tokenized_content": [2, 17593, 19871, 12441, 3, 43, 4770, 4378, 2007, 9823, 6952, 11056, 17576, 1031, 10054, 14657, 1920, 3335, 9255, 7538, 43, 5510, 21039, 2585, 18, 1920, 3]}]}
{"query": {"id": "q_4878", "content": "tumor [SEP] l arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, t", "tokenized_content": [2, 2798, 3, 54, 9345, 16, 24332, 16, 1930, 20276, 18, 2882, 2362, 2774, 1982, 2798, 17, 3294, 2014, 2430, 2444, 43, 2858, 2798, 2019, 1920, 4727, 1927, 2052, 4741, 16, 3]}, "items": [{"id": "p_4878", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4879", "content": "renal failure [SEP] l tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and ", "tokenized_content": [2, 4604, 4574, 3, 54, 2960, 2014, 1920, 5009, 2877, 12747, 1977, 2084, 3572, 16, 2882, 4604, 4574, 2278, 1998, 18969, 1942, 9284, 27880, 1930, 1920, 10679, 1930, 3]}, "items": [{"id": "p_4879", "content": "Renal Insufficiency [SEP] Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ", "score": 1, "type": null, "tokenized_content": [2, 4604, 14566, 3, 2961, 1922, 2154, 1920, 11770, 2385, 4535, 1920, 2791, 2237, 1922, 1920, 3682, 1942, 7989, 10437, 1036, 16, 18410, 6960, 16, 1930, 6698, 3]}]}
{"query": {"id": "q_4880", "content": "nephrotoxicity [SEP] ot examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow", "tokenized_content": [2, 27880, 3, 7608, 3572, 16, 2882, 4604, 4574, 2278, 1998, 18969, 1942, 9284, 27880, 1930, 1920, 10679, 1930, 17100, 1942, 2838, 17, 2719, 3622, 6599, 3]}, "items": [{"id": "p_4880", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_4881", "content": "anemia [SEP] haracterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, ", "tokenized_content": [2, 10679, 3, 4303, 2422, 2301, 2007, 4604, 14566, 16, 2703, 9506, 10982, 21515, 10679, 16, 1930, 5394, 17100, 13, 2256, 2311, 1956, 9284, 16, 3]}, "items": [{"id": "p_4881", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_4882", "content": "bone marrow suppression [SEP] hrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression.", "tokenized_content": [2, 3622, 6599, 6412, 3, 3668, 11930, 1930, 1920, 10679, 1930, 17100, 1942, 2838, 17, 2719, 3622, 6599, 6412, 18, 3]}, "items": [{"id": "p_4882", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_4883", "content": "nelarabine [SEP] Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediat", "tokenized_content": [2, 2069, 5148, 5524, 23605, 1021, 3, 17577, 3181, 1956, 2069, 5148, 5524, 23605, 1021, 16, 18892, 16, 1930, 17135, 1922, 18189, 19, 10923, 15071, 3801, 3]}, "items": [{"id": "p_4883", "content": "nelarabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2069, 5148, 5524, 23605, 1021, 3, 3]}]}
{"query": {"id": "q_4884", "content": "etoposide [SEP] Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell ", "tokenized_content": [2, 18892, 3, 17577, 3181, 1956, 2069, 5148, 5524, 23605, 1021, 16, 18892, 16, 1930, 17135, 1922, 18189, 19, 10923, 16658, 62, 17, 2024, 3]}, "items": [{"id": "p_4884", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_4885", "content": "cyclophosphamide [SEP] Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemi", "tokenized_content": [2, 17135, 3, 17577, 3181, 1956, 2069, 5148, 5524, 23605, 1021, 16, 18892, 16, 1930, 17135, 1922, 18189, 19, 10923, 16658, 62, 17, 2024, 24403, 5104, 3336, 7395, 3]}, "items": [{"id": "p_4885", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4886", "content": "T-cell lymphoblastic leukaemia [SEP] oposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.", "tokenized_content": [2, 62, 17, 2024, 24403, 23099, 3, 2494, 8028, 16, 1930, 17135, 1922, 18189, 19, 10923, 16658, 62, 17, 2024, 24403, 23099, 1930, 8636, 18, 3]}, "items": [{"id": "p_4886", "content": "Leukemia, T-Cell [SEP] A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 62, 17, 2024, 3, 43, 6558, 2573, 1927, 1920, 62, 17, 7257, 1922, 1920, 3622, 6599, 16, 15004, 16, 1930, 19, 2014, 2877, 18, 3]}]}
{"query": {"id": "q_4887", "content": "nelarabine [SEP] A combination of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and cyclophosphamide (CPM) an", "tokenized_content": [2, 2069, 5148, 5524, 23605, 1021, 3, 43, 3921, 1927, 25, 46, 1927, 2069, 5148, 5524, 23605, 1021, 12, 20289, 1029, 13, 1956, 25, 46, 1927, 18892, 12, 9314, 13, 1930, 3]}, "items": [{"id": "p_4887", "content": "nelarabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2069, 5148, 5524, 23605, 1021, 3, 3]}]}
{"query": {"id": "q_4888", "content": "AraG [SEP] A combination of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prop", "tokenized_content": [2, 20289, 1029, 3, 43, 3921, 1927, 25, 46, 1927, 2069, 5148, 5524, 23605, 1021, 12, 20289, 1029, 13, 1956, 25, 46, 1927, 18892, 12, 9314, 13, 1930, 17135, 12, 21087, 3]}, "items": [{"id": "p_4888", "content": "nelarabine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2069, 5148, 5524, 23605, 1021, 3, 3]}]}
{"query": {"id": "q_4889", "content": "etoposide [SEP] A combination of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal ch", "tokenized_content": [2, 18892, 3, 43, 3921, 1927, 25, 46, 1927, 2069, 5148, 5524, 23605, 1021, 12, 20289, 1029, 13, 1956, 25, 46, 1927, 18892, 12, 9314, 13, 1930, 17135, 12, 21087, 13, 3]}, "items": [{"id": "p_4889", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_4890", "content": "VP [SEP]  combination of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal chemot", "tokenized_content": [2, 9314, 3, 3921, 1927, 25, 46, 1927, 2069, 5148, 5524, 23605, 1021, 12, 20289, 1029, 13, 1956, 25, 46, 1927, 18892, 12, 9314, 13, 1930, 17135, 12, 21087, 13, 1930, 3]}, "items": [{"id": "p_4890", "content": "Etoposide [SEP] A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a co", "score": 1, "type": null, "tokenized_content": [2, 18892, 3, 43, 8762, 18801, 4905, 4116, 2002, 10533, 1927, 10181, 13384, 11140, 1988, 9826, 11775, 2455, 18, 18892, 7042, 2678, 4271, 2007, 7402, 43, 2081, 3]}]}
{"query": {"id": "q_4891", "content": "cyclophosphamide [SEP] tion of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal chemotherapy was used as sal", "tokenized_content": [2, 17135, 3, 8685, 1916, 1927, 25, 46, 1927, 2069, 5148, 5524, 23605, 1021, 12, 20289, 1029, 13, 1956, 25, 46, 1927, 18892, 12, 9314, 13, 1930, 17135, 12, 21087, 13, 3]}, "items": [{"id": "p_4891", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4892", "content": "CPM [SEP] arabine (AraG) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal chemotherapy was used as salvage ", "tokenized_content": [2, 21087, 3, 20790, 1021, 12, 20289, 1029, 13, 1956, 25, 46, 1927, 18892, 12, 9314, 13, 1930, 17135, 12, 21087, 13, 1930, 14847, 22782, 5318, 1982, 2251, 1966, 17577, 3]}, "items": [{"id": "p_4892", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4893", "content": "T-cell leukaemia [SEP] s salvage therapy in seven children with refractory or relapsed T-cell leukaemia or lymphoma. The most common side effects attributable to the A", "tokenized_content": [2, 62, 17, 2024, 23099, 3, 61, 17577, 3181, 1922, 5260, 3069, 1956, 10923, 2014, 18189, 62, 17, 2024, 23099, 2014, 8636, 18, 1920, 2501, 3059, 4159, 2564, 11081, 1942, 1920, 3]}, "items": [{"id": "p_4893", "content": "Leukemia, T-Cell [SEP] A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8111, 16, 62, 17, 2024, 3, 43, 6558, 2573, 1927, 1920, 62, 17, 7257, 1922, 1920, 3622, 6599, 16, 15004, 16, 1930, 19, 2014, 2877, 18, 3]}]}
{"query": {"id": "q_4894", "content": "neuropathy [SEP] tributable to the AraG included Grade 2 and 3 sensory and motor neuropathy and musculoskeletal pain. Haematological toxicity was greater f", "tokenized_content": [2, 13177, 3, 14521, 10737, 1942, 1920, 20289, 1029, 3063, 4927, 22, 1930, 23, 6893, 1930, 4842, 13177, 1930, 15322, 3594, 18, 28691, 5532, 1982, 3430, 48, 3]}, "items": [{"id": "p_4894", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4895", "content": "musculoskeletal pain [SEP] he AraG included Grade 2 and 3 sensory and motor neuropathy and musculoskeletal pain. Haematological toxicity was greater for the combination than A", "tokenized_content": [2, 15322, 3594, 3, 2234, 20289, 1029, 3063, 4927, 22, 1930, 23, 6893, 1930, 4842, 13177, 1930, 15322, 3594, 18, 28691, 5532, 1982, 3430, 1958, 1920, 3921, 2254, 43, 3]}, "items": [{"id": "p_4895", "content": "Musculoskeletal Pain [SEP] Discomfort stemming from muscles, LIGAMENTS, tendons, and bones.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15322, 3594, 3, 15335, 4402, 9069, 2037, 7848, 16, 27831, 16, 23517, 16, 1930, 14153, 18, 3]}]}
{"query": {"id": "q_4896", "content": "Haematological toxicity [SEP]  2 and 3 sensory and motor neuropathy and musculoskeletal pain. Haematological toxicity was greater for the combination than AraG alone, although media", "tokenized_content": [2, 28691, 5532, 3, 22, 1930, 23, 6893, 1930, 4842, 13177, 1930, 15322, 3594, 18, 28691, 5532, 1982, 3430, 1958, 1920, 3921, 2254, 20289, 1029, 4298, 16, 2876, 4996, 3]}, "items": [{"id": "p_4896", "content": "Hematologic Diseases [SEP] Disorders of the blood and blood forming tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18251, 3902, 3, 4414, 1927, 1920, 2877, 1930, 2877, 7402, 3878, 18, 3]}]}
{"query": {"id": "q_4897", "content": "neurological toxicity [SEP] rapy in synchrony with etoposide and cyclophosphamide, although neurological toxicity must be closely monitored.", "tokenized_content": [2, 7605, 5532, 3, 3694, 1012, 1922, 21466, 1956, 18892, 1930, 17135, 16, 2876, 7605, 5532, 4902, 1998, 6538, 7027, 18, 3]}, "items": [{"id": "p_4897", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_4898", "content": "sulphasalazine [SEP] The 3-week sulphasalazine syndrome strikes again.", "tokenized_content": [2, 13528, 14046, 10119, 3, 1920, 23, 17, 2982, 13528, 14046, 10119, 4741, 2114, 5909, 1036, 3116, 18, 3]}, "items": [{"id": "p_4898", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_4899", "content": "dermatitis [SEP] A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th da", "tokenized_content": [2, 18006, 3, 43, 3540, 17, 2476, 17, 4156, 17786, 1012, 3530, 43, 4713, 30439, 1927, 18006, 16, 9087, 16, 25948, 1930, 7977, 16, 7828, 1990, 1920, 2752, 1963, 3692, 3]}, "items": [{"id": "p_4899", "content": "Dermatitis [SEP] Any inflammation of the skin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18006, 3, 2967, 4531, 1927, 1920, 4407, 18, 3]}]}
{"query": {"id": "q_4900", "content": "fever [SEP] A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a ", "tokenized_content": [2, 9087, 3, 43, 3540, 17, 2476, 17, 4156, 17786, 1012, 3530, 43, 4713, 30439, 1927, 18006, 16, 9087, 16, 25948, 1930, 7977, 16, 7828, 1990, 1920, 2752, 1963, 3007, 1927, 3]}, "items": [{"id": "p_4900", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_4901", "content": "lymphadenopathy [SEP] 4-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral su", "tokenized_content": [2, 25948, 3, 24, 17, 2476, 17, 4156, 17786, 1012, 3530, 43, 4713, 30439, 1927, 18006, 16, 9087, 16, 25948, 1930, 7977, 16, 7828, 1990, 1920, 2752, 1963, 3007, 1927, 43, 3]}, "items": [{"id": "p_4901", "content": "Lymphatic Diseases [SEP] Diseases of LYMPH; LYMPH NODES; or LYMPHATIC VESSELS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13388, 3902, 3, 3902, 1927, 3541, 31, 3541, 6263, 31, 2014, 13388, 7208, 18, 3]}]}
{"query": {"id": "q_4902", "content": "hepatitis [SEP] loped a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine f", "tokenized_content": [2, 7977, 3, 24910, 1007, 43, 4713, 30439, 1927, 18006, 16, 9087, 16, 25948, 1930, 7977, 16, 7828, 1990, 1920, 2752, 1963, 3007, 1927, 43, 4914, 1927, 4726, 13528, 14046, 10119, 3]}, "items": [{"id": "p_4902", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4903", "content": "sulphasalazine [SEP] hy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis. Cervical and inguinal l", "tokenized_content": [2, 13528, 14046, 10119, 3, 4527, 1930, 7977, 16, 7828, 1990, 1920, 2752, 1963, 3007, 1927, 43, 4914, 1927, 4726, 13528, 14046, 10119, 1958, 2375, 1037, 17, 3136, 13053, 8884, 18, 3]}, "items": [{"id": "p_4903", "content": "Sulfasalazine [SEP] A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabol", "score": 1, "type": null, "tokenized_content": [2, 5141, 14046, 10119, 3, 43, 2838, 1988, 1977, 2251, 1922, 1920, 4280, 1927, 3769, 9472, 3902, 18, 2496, 2455, 1977, 4933, 3311, 1942, 14958, 1922, 2496, 3074, 3]}]}
{"query": {"id": "q_4904", "content": "rheumatoid arthritis [SEP] e 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features ", "tokenized_content": [2, 13053, 8884, 3, 47, 2752, 1963, 3007, 1927, 43, 4914, 1927, 4726, 13528, 14046, 10119, 1958, 2375, 1037, 17, 3136, 13053, 8884, 18, 6775, 1930, 19820, 3541, 6267, 9782, 2594, 3]}, "items": [{"id": "p_4904", "content": "Arthritis, Rheumatoid [SEP] A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular stru", "score": 1, "type": null, "tokenized_content": [2, 8884, 16, 13053, 3, 43, 3724, 5510, 2573, 16, 5985, 1927, 1920, 12648, 16, 4961, 2007, 3769, 2840, 1922, 1920, 14828, 5726, 1930, 13244, 2114, 1032, 3]}]}
{"query": {"id": "q_4905", "content": "lymphadenitis [SEP] l lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic", "tokenized_content": [2, 18210, 3678, 3, 54, 3541, 6267, 9782, 2594, 1920, 4075, 1927, 4010, 10341, 3600, 1941, 18210, 3678, 16, 2458, 1956, 25940, 4151, 3827, 27932, 2475, 1930, 8753, 21254, 3]}, "items": [{"id": "p_4905", "content": "Lymphadenitis [SEP] Inflammation of the lymph nodes.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18210, 3678, 3, 4531, 1927, 1920, 3541, 6263, 18, 3]}]}
{"query": {"id": "q_4906", "content": "adverse drug reaction [SEP] c infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with", "tokenized_content": [2, 5246, 2838, 3227, 3, 45, 22110, 16, 2979, 4324, 6125, 8322, 16, 12855, 1927, 1925, 5246, 2838, 3227, 18, 43, 2982, 3690, 16, 5257, 8547, 2031, 2838, 17, 2719, 7977, 3]}, "items": [{"id": "p_4906", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4907", "content": "drug-induced hepatitis [SEP]  suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (b", "tokenized_content": [2, 2838, 17, 2719, 7977, 3, 12855, 1927, 1925, 5246, 2838, 3227, 18, 43, 2982, 3690, 16, 5257, 8547, 2031, 2838, 17, 2719, 7977, 16, 2458, 1956, 1920, 2990, 1927, 2246, 3]}, "items": [{"id": "p_4907", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_4908", "content": "autoimmunity [SEP] e of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened", "tokenized_content": [2, 17715, 3, 47, 1927, 2246, 17, 4254, 15510, 12, 2308, 2084, 1956, 2303, 4432, 1927, 17715, 13, 16, 1930, 7936, 2007, 2779, 17, 3090, 4574, 1930, 9019, 16, 9484, 5106, 3]}, "items": [{"id": "p_4908", "content": "Autoimmune Diseases [SEP] Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are ", "score": 1, "type": null, "tokenized_content": [2, 8904, 3902, 3, 4414, 1988, 2032, 4378, 2007, 1920, 3372, 1927, 3788, 1988, 9793, 1956, 4423, 3878, 2014, 3743, 7917, 2094, 1988, 2032, 3]}]}
{"query": {"id": "q_4909", "content": "multi-organ failure [SEP] but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks afte", "tokenized_content": [2, 2779, 17, 3090, 4574, 3, 2308, 2084, 1956, 2303, 4432, 1927, 17715, 13, 16, 1930, 7936, 2007, 2779, 17, 3090, 4574, 1930, 9019, 16, 9484, 5106, 18, 4693, 5326, 8545, 3]}, "items": [{"id": "p_4909", "content": "Multiple Organ Failure [SEP] A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with", "score": 1, "type": null, "tokenized_content": [2, 3137, 3090, 4574, 3, 43, 7529, 2625, 5394, 4378, 2007, 4252, 4574, 1927, 2980, 7393, 2427, 1966, 1920, 9193, 16, 3568, 16, 5245, 16, 4231, 1956, 3]}]}
{"query": {"id": "q_4910", "content": "sepsis [SEP] rs of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the comme", "tokenized_content": [2, 9019, 3, 4366, 1927, 17715, 13, 16, 1930, 7936, 2007, 2779, 17, 3090, 4574, 1930, 9019, 16, 9484, 5106, 18, 4693, 5326, 8545, 2673, 25, 3625, 2256, 1920, 2689, 1021, 3]}, "items": [{"id": "p_4910", "content": "Sepsis [SEP] Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dys", "score": 1, "type": null, "tokenized_content": [2, 9019, 3, 5510, 3769, 2644, 4741, 1956, 43, 9253, 2014, 9407, 7465, 10383, 18, 2469, 9019, 1977, 2458, 1956, 3090, 3890, 3]}]}
{"query": {"id": "q_4911", "content": "massive hepatocellular necrosis [SEP]  of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interst", "tokenized_content": [2, 12944, 12457, 7476, 3, 1927, 3656, 2838, 3181, 18, 2753, 17, 20796, 4981, 2594, 3095, 1927, 12944, 12457, 7476, 16, 3939, 14625, 27169, 16, 8083, 3939, 25860, 1037, 17, 7934, 3]}, "items": [{"id": "p_4911", "content": "Massive Hepatic Necrosis [SEP] Extensive and rapid death of parenchymal cells in the LIVER, often due to exposure to toxic materials. It is characterized by a ", "score": 1, "type": null, "tokenized_content": [2, 12944, 6095, 7476, 3, 6475, 1930, 4052, 3539, 1927, 19223, 2094, 1922, 1920, 3568, 16, 3868, 2810, 1942, 3395, 1942, 6161, 4751, 18, 2176, 1977, 4378, 2007, 43, 3]}]}
{"query": {"id": "q_4912", "content": "myocarditis [SEP] ence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone m", "tokenized_content": [2, 27169, 3, 3350, 1021, 1927, 12944, 12457, 7476, 16, 3939, 14625, 27169, 16, 8083, 3939, 25860, 1037, 17, 11584, 25064, 1930, 6475, 3622, 55, 3]}, "items": [{"id": "p_4912", "content": "Myocarditis [SEP] Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCY", "score": 1, "type": null, "tokenized_content": [2, 27169, 3, 3769, 4028, 1927, 1920, 12330, 12430, 1927, 1920, 4003, 12, 13295, 13, 2154, 3211, 1922, 4047, 1942, 1920, 4435, 3760, 2094, 12, 15924, 13796, 3]}]}
{"query": {"id": "q_4913", "content": "nephritis [SEP] e hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of maligna", "tokenized_content": [2, 25064, 3, 47, 14625, 27169, 16, 8083, 3939, 25860, 1037, 17, 11584, 25064, 1930, 6475, 3622, 6599, 7476, 16, 1956, 2239, 3095, 1927, 5036, 1019, 3]}, "items": [{"id": "p_4913", "content": "Nephritis [SEP] Inflammation of any part of the KIDNEY.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25064, 3, 4531, 1927, 2967, 3131, 1927, 1920, 5245, 18, 3]}]}
{"query": {"id": "q_4914", "content": "bone marrow necrosis [SEP] rditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico", "tokenized_content": [2, 3622, 6599, 7476, 3, 8695, 3678, 16, 8083, 3939, 25860, 1037, 17, 11584, 25064, 1930, 6475, 3622, 6599, 7476, 16, 1956, 2239, 3095, 1927, 10248, 18, 2176, 1977, 6212, 1988, 3]}, "items": [{"id": "p_4914", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_4915", "content": "malignancy [SEP] phritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chron", "tokenized_content": [2, 10248, 3, 17252, 3678, 1930, 6475, 3622, 6599, 7476, 16, 1956, 2239, 3095, 1927, 10248, 18, 2176, 1977, 6212, 1988, 1920, 6248, 1037, 17, 6598, 4075, 1930, 3589, 3]}, "items": [{"id": "p_4915", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_4916", "content": "Bupropion [SEP] Bupropion (Zyban) toxicity.", "tokenized_content": [2, 22955, 2928, 2001, 3, 22955, 2928, 2001, 12, 68, 16924, 1928, 13, 5532, 18, 3]}, "items": [{"id": "p_4916", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_4917", "content": "Zyban [SEP] Bupropion (Zyban) toxicity.", "tokenized_content": [2, 68, 16924, 1928, 3, 22955, 2928, 2001, 12, 68, 16924, 1928, 13, 5532, 18, 3]}, "items": [{"id": "p_4917", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_4918", "content": "toxicity [SEP] Bupropion (Zyban) toxicity.", "tokenized_content": [2, 5532, 3, 22955, 2928, 2001, 12, 68, 16924, 1928, 13, 5532, 18, 3]}, "items": [{"id": "p_4918", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4919", "content": "Bupropion [SEP] Bupropion is a monocyclic antidepressant structurally related to amphetam", "tokenized_content": [2, 22955, 2928, 2001, 3, 22955, 2928, 2001, 1977, 43, 18688, 13153, 14183, 12171, 2712, 1942, 9141, 9215, 1035, 3]}, "items": [{"id": "p_4919", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_4920", "content": "antidepressant [SEP] Bupropion is a monocyclic antidepressant structurally related to amphetamine. Zyban, a sustained-release", "tokenized_content": [2, 14183, 3, 22955, 2928, 2001, 1977, 43, 18688, 13153, 14183, 12171, 2712, 1942, 19057, 18, 68, 16924, 1928, 16, 43, 7637, 17, 4012, 3]}, "items": [{"id": "p_4920", "content": "Antidepressive Agents [SEP] Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE ", "score": 1, "type": null, "tokenized_content": [2, 11248, 2320, 4820, 3, 9494, 17, 9868, 4195, 2251, 5985, 1922, 1920, 2311, 1927, 11863, 4414, 1930, 2712, 2961, 18, 2980, 25368, 10488, 3]}]}
{"query": {"id": "q_4921", "content": "amphetamine [SEP] upropion is a monocyclic antidepressant structurally related to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochlor", "tokenized_content": [2, 19057, 3, 13238, 2011, 2001, 1977, 43, 18688, 13153, 14183, 12171, 2712, 1942, 19057, 18, 68, 16924, 1928, 16, 43, 7637, 17, 4012, 10126, 1927, 22955, 2928, 2001, 14369, 3]}, "items": [{"id": "p_4921", "content": "Amphetamine [SEP] A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blockin", "score": 1, "type": null, "tokenized_content": [2, 19057, 3, 43, 9974, 4101, 7580, 2433, 24252, 1930, 26638, 1947, 21870, 18, 19057, 2258, 3137, 3531, 1927, 4615, 2710, 3367, 1921, 3]}]}
{"query": {"id": "q_4922", "content": "Zyban [SEP]  monocyclic antidepressant structurally related to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochloride, wa", "tokenized_content": [2, 68, 16924, 1928, 3, 18688, 13153, 14183, 12171, 2712, 1942, 19057, 18, 68, 16924, 1928, 16, 43, 7637, 17, 4012, 10126, 1927, 22955, 2928, 2001, 16675, 16, 4114, 3]}, "items": [{"id": "p_4922", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_4923", "content": "bupropion hydrochloride [SEP] lated to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochloride, was recently released in Ireland, as a smoking cessation aid. ", "tokenized_content": [2, 22955, 2928, 2001, 16675, 3, 5058, 1007, 1942, 19057, 18, 68, 16924, 1928, 16, 43, 7637, 17, 4012, 10126, 1927, 22955, 2928, 2001, 16675, 16, 1982, 3998, 6988, 1922, 20416, 3]}, "items": [{"id": "p_4923", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_4924", "content": "overdose [SEP] sation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Ce", "tokenized_content": [2, 21090, 3, 15036, 1916, 8379, 18, 1922, 1920, 3754, 26, 3221, 3328, 2176, 11, 61, 6935, 16, 2369, 21090, 2919, 2162, 2252, 2568, 1942, 1920, 3852, 15501, 1036, 2988, 5827, 3]}, "items": [{"id": "p_4924", "content": "Drug Overdose [SEP] Accidental or deliberate use of a medication or street drug in excess of normal dosage.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2838, 21090, 3, 24842, 2014, 24921, 13108, 2485, 1927, 43, 6093, 2014, 19869, 2838, 1922, 5799, 1927, 2791, 9998, 18, 3]}]}
{"query": {"id": "q_4925", "content": "toxicity [SEP] al Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included tachycardia, drowsiness, hallucinatio", "tokenized_content": [2, 5532, 3, 1969, 15501, 1036, 2988, 8141, 18, 28, 2132, 3530, 3601, 1927, 5532, 18, 3059, 4075, 3063, 17397, 16, 29247, 6777, 1979, 16, 20958, 4058, 1914, 1037, 3]}, "items": [{"id": "p_4925", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4926", "content": "tachycardia [SEP] tients developed symptoms of toxicity. Common features included tachycardia, drowsiness, hallucinations and convulsions. Two patients devel", "tokenized_content": [2, 17397, 3, 19108, 4905, 1036, 3530, 3601, 1927, 5532, 18, 3059, 4075, 3063, 17397, 16, 29247, 6777, 1979, 16, 27013, 1930, 4772, 19389, 18, 2288, 2132, 4251, 1938, 3]}, "items": [{"id": "p_4926", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_4927", "content": "hallucinations [SEP]  of toxicity. Common features included tachycardia, drowsiness, hallucinations and convulsions. Two patients developed severe cardiac arrhythm", "tokenized_content": [2, 27013, 3, 1927, 5532, 18, 3059, 4075, 3063, 17397, 16, 29247, 6777, 1979, 16, 27013, 1930, 4772, 19389, 18, 2288, 2132, 3530, 4010, 4435, 11335, 1035, 3]}, "items": [{"id": "p_4927", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_4928", "content": "convulsions [SEP] n features included tachycardia, drowsiness, hallucinations and convulsions. Two patients developed severe cardiac arrhythmias, including o", "tokenized_content": [2, 4772, 19389, 3, 56, 4075, 3063, 17397, 16, 29247, 6777, 1979, 16, 27013, 1930, 4772, 19389, 18, 2288, 2132, 3530, 4010, 4435, 16934, 16, 2710, 57, 3]}, "items": [{"id": "p_4928", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4929", "content": "cardiac arrhythmias [SEP] , hallucinations and convulsions. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a cardiac", "tokenized_content": [2, 4435, 16934, 3, 16, 27013, 1930, 4772, 19389, 18, 2288, 2132, 3530, 4010, 4435, 16934, 16, 2710, 2340, 2774, 2746, 1982, 14037, 19633, 2894, 43, 4435, 3]}, "items": [{"id": "p_4929", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_4930", "content": "cardiac arrest [SEP] ythmias, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a", "tokenized_content": [2, 4435, 8048, 3, 24412, 21416, 10657, 16, 2710, 2340, 2774, 2746, 1982, 14037, 19633, 2894, 43, 4435, 8048, 18, 2136, 2132, 8294, 2979, 19067, 18, 2038, 3809, 43, 3087, 1927, 3]}, "items": [{"id": "p_4930", "content": "Heart Arrest [SEP] Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most c", "score": 1, "type": null, "tokenized_content": [2, 4003, 8048, 3, 10975, 1927, 4003, 17984, 2014, 6497, 8332, 18, 2647, 2176, 1977, 2868, 2651, 43, 3855, 4814, 16, 4003, 8048, 2112, 1998, 9432, 1922, 2501, 45, 3]}]}
{"query": {"id": "q_4931", "content": "bupropion [SEP] lated to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochloride, was recently released in Ireland, as a smoking c", "tokenized_content": [2, 22955, 2928, 2001, 3, 5058, 1007, 1942, 19057, 18, 68, 16924, 1928, 16, 43, 7637, 17, 4012, 10126, 1927, 22955, 2928, 2001, 16675, 16, 1982, 3998, 6988, 1922, 20416, 16, 3]}, "items": [{"id": "p_4931", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_4932", "content": "seizures [SEP] tive therapy, following ingestion of 13.5g bupropion. Recurrent seizures were treated with diazepam and broad complex tachycardia was su", "tokenized_content": [2, 10060, 3, 8685, 1961, 3181, 16, 2894, 14195, 1927, 2590, 18, 19950, 22955, 2928, 2001, 18, 7457, 10060, 1985, 2868, 1956, 26079, 1930, 4949, 2796, 17397, 1982, 2020, 3]}, "items": [{"id": "p_4932", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_4933", "content": "diazepam [SEP] estion of 13.5g bupropion. Recurrent seizures were treated with diazepam and broad complex tachycardia was successfully treated with ade", "tokenized_content": [2, 26079, 3, 3255, 2001, 1927, 2590, 18, 19950, 22955, 2928, 2001, 18, 7457, 10060, 1985, 2868, 1956, 26079, 1930, 4949, 2796, 17397, 1982, 6664, 2868, 1956, 23846, 3]}, "items": [{"id": "p_4933", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_4934", "content": "adenosine [SEP] pam and broad complex tachycardia was successfully treated with adenosine. Zyban caused significant neurological and cardiovascular toxic", "tokenized_content": [2, 10125, 3, 11888, 1930, 4949, 2796, 17397, 1982, 6664, 2868, 1956, 10125, 18, 68, 16924, 1928, 4189, 2228, 7605, 1930, 5321, 6161, 3]}, "items": [{"id": "p_4934", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_4935", "content": "cardiovascular toxicity [SEP] eated with adenosine. Zyban caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered w", "tokenized_content": [2, 5321, 5532, 3, 13619, 1919, 1956, 10125, 18, 68, 16924, 1928, 4189, 2228, 7605, 1930, 5321, 5532, 1922, 21090, 18, 1920, 2889, 6161, 2564, 3066, 1998, 3311, 65, 3]}, "items": [{"id": "p_4935", "content": "Cardiovascular Diseases [SEP] Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5321, 3902, 3, 6598, 2961, 5884, 1920, 5321, 2433, 2710, 1920, 4003, 31, 1920, 2877, 7208, 31, 2014, 1920, 10796, 26872, 18, 3]}]}
{"query": {"id": "q_4936", "content": "indocyanine green [SEP] Survey of complications of indocyanine green angiography in Japan.", "tokenized_content": [2, 2063, 29193, 4524, 3, 4711, 1927, 5021, 1927, 2063, 29193, 4524, 11676, 1922, 5834, 18, 3]}, "items": [{"id": "p_4936", "content": "Indocyanine Green [SEP] A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2063, 29193, 4524, 3, 43, 12258, 6299, 29193, 8347, 1988, 1977, 2251, 4785, 2169, 1922, 3568, 2347, 4026, 1930, 1942, 3415, 2877, 3776, 1930, 4435, 6647, 18, 3]}]}
{"query": {"id": "q_4937", "content": "indocyanine green [SEP] PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire", "tokenized_content": [2, 2063, 29193, 4524, 3, 5120, 30, 2038, 3747, 1920, 5407, 1927, 2063, 29193, 4524, 1958, 2485, 1922, 18862, 11676, 18, 2860, 30, 2038, 8437, 43, 5564, 3]}, "items": [{"id": "p_4937", "content": "Indocyanine Green [SEP] A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2063, 29193, 4524, 3, 43, 12258, 6299, 29193, 8347, 1988, 1977, 2251, 4785, 2169, 1922, 3568, 2347, 4026, 1930, 1942, 3415, 2877, 3776, 1930, 4435, 6647, 18, 3]}]}
{"query": {"id": "q_4938", "content": "nausea [SEP] rse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and", "tokenized_content": [2, 13759, 3, 4366, 1021, 5298, 12, 20, 18, 3540, 9, 13, 16, 5656, 1927, 2154, 1985, 5809, 5298, 2427, 1966, 13759, 16, 1975, 7744, 6666, 16, 27986, 1943, 16, 20687, 3]}, "items": [{"id": "p_4938", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_4939", "content": "exanthema [SEP] tions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not re", "tokenized_content": [2, 1975, 7744, 6666, 3, 8685, 2101, 12, 20, 18, 3540, 9, 13, 16, 5656, 1927, 2154, 1985, 5809, 5298, 2427, 1966, 13759, 16, 1975, 7744, 6666, 16, 27986, 1943, 16, 3]}, "items": [{"id": "p_4939", "content": "Exanthema [SEP] Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with sim", "score": 1, "type": null, "tokenized_content": [2, 1975, 7744, 6666, 3, 3902, 1922, 2154, 4407, 25655, 1036, 2014, 18469, 1918, 2032, 43, 8753, 15570, 18, 24466, 16, 3798, 2427, 3902, 1985, 2910, 1956, 2328, 3]}]}
{"query": {"id": "q_4940", "content": "urtication [SEP] %), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatm", "tokenized_content": [2, 27986, 1943, 3, 9, 13, 16, 5656, 1927, 2154, 1985, 5809, 5298, 2427, 1966, 13759, 16, 1975, 7744, 6666, 16, 27986, 1943, 16, 20687, 8254, 16, 1930, 24414, 1942, 29550, 3]}, "items": [{"id": "p_4940", "content": "Urticaria [SEP] A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability", "score": 1, "type": null, "tokenized_content": [2, 27986, 6148, 3, 43, 4541, 3227, 1927, 1920, 4407, 4378, 2007, 23349, 1930, 8372, 1923, 3337, 2810, 1942, 6579, 2760, 1927, 4541, 8828, 3]}]}
{"query": {"id": "q_4941", "content": "itchiness [SEP] hich were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also r", "tokenized_content": [2, 20687, 8254, 3, 27305, 1023, 1985, 5809, 5298, 2427, 1966, 13759, 16, 1975, 7744, 6666, 16, 27986, 1943, 16, 20687, 8254, 16, 1930, 24414, 1942, 29550, 2010, 16, 1930, 2811, 3]}, "items": [{"id": "p_4941", "content": "Pruritus [SEP] An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27496, 3, 1925, 10702, 20687, 1941, 15826, 1988, 9300, 1920, 11460, 1021, 1942, 10010, 2014, 18480, 1920, 4407, 1942, 5649, 13104, 18, 3]}]}
{"query": {"id": "q_4942", "content": "pain [SEP] , and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypoten", "tokenized_content": [2, 3594, 3, 16, 1930, 2811, 2084, 4350, 2311, 18, 2222, 4562, 1985, 2340, 3087, 1927, 3594, 1927, 1920, 7920, 16, 2154, 3414, 2311, 16, 1930, 2288, 2919, 1927, 12201, 1917, 3]}, "items": [{"id": "p_4942", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4943", "content": "hypotension [SEP] of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CON", "tokenized_content": [2, 16453, 3, 1927, 3594, 1927, 1920, 7920, 16, 2154, 3414, 2311, 16, 1930, 2288, 2919, 1927, 16453, 18, 1920, 2288, 12201, 3766, 2132, 3414, 2311, 1958, 7418, 18, 1962, 3]}, "items": [{"id": "p_4943", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4944", "content": "hypotensive [SEP] which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A compariso", "tokenized_content": [2, 12201, 3766, 3, 2154, 3414, 2311, 16, 1930, 2288, 2919, 1927, 16453, 18, 1920, 2288, 12201, 3766, 2132, 3414, 2311, 1958, 7418, 18, 4355, 30, 43, 3304, 1037, 3]}, "items": [{"id": "p_4944", "content": "Hypotension [SEP] Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DI", "score": 1, "type": null, "tokenized_content": [2, 16453, 3, 20756, 2330, 2877, 3772, 1988, 2112, 3211, 1922, 11391, 2877, 3426, 1942, 1920, 3068, 1930, 2303, 8970, 7393, 18, 3059, 3226, 1977, 2137, 3]}]}
{"query": {"id": "q_4945", "content": "shock [SEP] ypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to", "tokenized_content": [2, 7418, 3, 21995, 7229, 3355, 2001, 18, 1920, 2288, 12201, 3766, 2132, 3414, 2311, 1958, 7418, 18, 4355, 30, 43, 3723, 1927, 3528, 1927, 5246, 5298, 1942, 3]}, "items": [{"id": "p_4945", "content": "Shock [SEP] A pathological condition manifested by failure to perfuse or oxygenate vital organs.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7418, 3, 43, 6598, 2625, 16687, 2007, 4574, 1942, 5294, 2517, 2014, 4612, 2010, 8970, 7393, 18, 3]}]}
{"query": {"id": "q_4946", "content": "fluorescein sodium [SEP] een with the previously reported frequency of such reactions to fluorescein sodium indicated that indocyanine green is a safe as fluorescein for u", "tokenized_content": [2, 14167, 5227, 3, 11150, 1022, 1956, 1920, 3024, 2568, 3528, 1927, 2427, 5298, 1942, 14167, 5227, 3391, 1988, 2063, 29193, 4524, 1977, 43, 7672, 1966, 14167, 1958, 63, 3]}, "items": [{"id": "p_4946", "content": "Fluorescein [SEP] A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aq", "score": 1, "type": null, "tokenized_content": [2, 14167, 3, 43, 19686, 1935, 8413, 8347, 1988, 5107, 7463, 17, 4524, 1922, 2791, 12650, 8030, 1930, 10944, 4524, 1922, 43, 2253, 10746, 3649, 2427, 1966, 1920, 11331, 3]}]}
{"query": {"id": "q_4947", "content": "fluorescein [SEP] een with the previously reported frequency of such reactions to fluorescein sodium indicated that indocyanine green is a safe as fluorescei", "tokenized_content": [2, 14167, 3, 11150, 1022, 1956, 1920, 3024, 2568, 3528, 1927, 2427, 5298, 1942, 14167, 5227, 3391, 1988, 2063, 29193, 4524, 1977, 43, 7672, 1966, 17871, 14209, 3]}, "items": [{"id": "p_4947", "content": "Fluorescein [SEP] A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aq", "score": 1, "type": null, "tokenized_content": [2, 14167, 3, 43, 19686, 1935, 8413, 8347, 1988, 5107, 7463, 17, 4524, 1922, 2791, 12650, 8030, 1930, 10944, 4524, 1922, 43, 2253, 10746, 3649, 2427, 1966, 1920, 11331, 3]}]}
{"query": {"id": "q_4948", "content": "Bradykinin [SEP] Bradykinin receptors antagonists and nitric oxide synthase inhibitors in v", "tokenized_content": [2, 25448, 3, 25448, 4086, 10515, 1930, 10233, 7491, 8921, 4472, 1922, 64, 3]}, "items": [{"id": "p_4948", "content": "Bradykinin [SEP] A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of ", "score": 1, "type": null, "tokenized_content": [2, 25448, 3, 43, 2447, 24010, 16716, 1988, 1977, 23958, 4152, 2037, 25846, 7650, 1922, 1920, 2877, 2597, 2176, 1977, 43, 6828, 2308, 3662, 17, 11698, 5899, 1927, 3]}]}
{"query": {"id": "q_4949", "content": "nitric oxide [SEP] Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced h", "tokenized_content": [2, 10233, 7491, 3, 25448, 4086, 10515, 1930, 10233, 7491, 8921, 4472, 1922, 25446, 1930, 26492, 2719, 50, 3]}, "items": [{"id": "p_4949", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_4950", "content": "vincristine [SEP] n receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and dia", "tokenized_content": [2, 25446, 3, 56, 4086, 10515, 1930, 10233, 7491, 8921, 4472, 1922, 25446, 1930, 26492, 2719, 21525, 1922, 5318, 1930, 25141, 3]}, "items": [{"id": "p_4950", "content": "Vincristine [SEP] Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)\n    ", "score": 1, "type": null, "tokenized_content": [2, 25446, 3, 11775, 29951, 3937, 2037, 24198, 1019, 13679, 1019, 18, 12, 14556, 16, 2513, 1963, 3347, 18, 13, 3]}]}
{"query": {"id": "q_4951", "content": "streptozotocin [SEP] gonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy ra", "tokenized_content": [2, 26492, 3, 8239, 3535, 1930, 10233, 7491, 8921, 4472, 1922, 25446, 1930, 26492, 2719, 21525, 1922, 5318, 1930, 6152, 13177, 4313, 3]}, "items": [{"id": "p_4951", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_4952", "content": "hyperalgesia [SEP] e synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.", "tokenized_content": [2, 21525, 3, 47, 8921, 4472, 1922, 25446, 1930, 26492, 2719, 21525, 1922, 5318, 1930, 6152, 13177, 3067, 2322, 18, 3]}, "items": [{"id": "p_4952", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4953", "content": "diabetic neuropathy [SEP] ine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.", "tokenized_content": [2, 6152, 13177, 3, 11116, 1930, 26492, 2719, 21525, 1922, 5318, 1930, 6152, 13177, 3067, 2322, 18, 3]}, "items": [{"id": "p_4953", "content": "Diabetic Neuropathies [SEP] Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result f", "score": 1, "type": null, "tokenized_content": [2, 6152, 8798, 2062, 3, 5009, 16, 13725, 16, 1930, 13598, 5507, 4414, 1988, 2032, 2458, 1956, 4032, 9695, 18, 2144, 2961, 5394, 3211, 48, 3]}]}
{"query": {"id": "q_4954", "content": "NO [SEP] OSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibi", "tokenized_content": [2, 2239, 3, 3125, 1021, 30, 1920, 4039, 1927, 1925, 14104, 4106, 1927, 10943, 2239, 8921, 12, 54, 17, 2239, 2419, 31, 21, 18, 20, 2786, 19, 3621, 5416, 13, 16, 3]}, "items": [{"id": "p_4954", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_4955", "content": "bradykinin [SEP] tagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) r", "tokenized_content": [2, 25448, 3, 5218, 13339, 2156, 1036, 1927, 11054, 1930, 10360, 4086, 30, 46, 17, 4582, 17, 37, 2483, 1010, 16, 7566, 1015, 16, 46, 17, 18298, 1027, 16, 25166, 1030, 3]}, "items": [{"id": "p_4955", "content": "Bradykinin [SEP] A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of ", "score": 1, "type": null, "tokenized_content": [2, 25448, 3, 43, 2447, 24010, 16716, 1988, 1977, 23958, 4152, 2037, 25846, 7650, 1922, 1920, 2877, 2597, 2176, 1977, 43, 6828, 2308, 3662, 17, 11698, 5899, 1927, 3]}]}
{"query": {"id": "q_4956", "content": "HOE 140 [SEP]  B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respective", "tokenized_content": [2, 6673, 1021, 8949, 3, 11054, 1930, 10360, 4086, 30, 46, 17, 4582, 17, 37, 2483, 1010, 16, 7566, 1015, 16, 46, 17, 18298, 1027, 16, 25166, 1030, 1025, 39, 25448, 3]}, "items": [{"id": "p_4956", "content": "icatibant [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 14784, 4397, 2031, 3, 3]}]}
{"query": {"id": "q_4957", "content": "des Arg10 HOE 140 [SEP] -[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozoto", "tokenized_content": [2, 2270, 4582, 2930, 6673, 1021, 8949, 3, 17, 37, 2483, 1010, 16, 7566, 1015, 16, 46, 17, 18298, 1027, 16, 25166, 1030, 1025, 39, 25448, 12, 6673, 1021, 8949, 31, 3]}, "items": [{"id": "p_4957", "content": "HOE 140, desArg(10)- [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6673, 1021, 8949, 16, 2270, 2419, 12, 2119, 13, 17, 3, 3]}]}
{"query": {"id": "q_4958", "content": "toxic (vincristine-induced) neuropathy [SEP] respectively, in model of diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy was investigated. METHODS: The changes in pain thresholds were ", "tokenized_content": [2, 6161, 12, 25446, 17, 2719, 13, 13177, 3, 2763, 16, 1922, 2322, 1927, 6152, 12, 26492, 17, 2719, 13, 1930, 6161, 12, 25446, 17, 2719, 13, 13177, 1982, 3845, 18, 3]}, "items": [{"id": "p_4958", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_4959", "content": "pain [SEP] e-induced) neuropathy was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modifi", "tokenized_content": [2, 3594, 3, 47, 17, 2719, 13, 13177, 1982, 3845, 18, 2860, 30, 1920, 2840, 1922, 3594, 9761, 1985, 3180, 2193, 5821, 5458, 17, 17, 1920, 2157, 1974, 1033, 3]}, "items": [{"id": "p_4959", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_4960", "content": "diabetic hyperalgesia [SEP] cible NO synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantl", "tokenized_content": [2, 6152, 21525, 3, 29435, 1952, 2239, 8921, 2308, 2084, 5121, 2239, 8921, 2455, 7268, 6152, 21525, 18, 9111, 1956, 54, 17, 2239, 2419, 1930, 54, 17, 20282, 2308, 2084, 27, 3]}, "items": [{"id": "p_4960", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4961", "content": "hyperalgesia [SEP] synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantl", "tokenized_content": [2, 21525, 3, 8921, 2308, 2084, 5121, 2239, 8921, 2455, 7268, 6152, 21525, 18, 9111, 1956, 54, 17, 2239, 2419, 1930, 54, 17, 20282, 2308, 2084, 27, 17, 7781, 16, 2228, 3]}, "items": [{"id": "p_4961", "content": "Hyperalgesia [SEP] An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCIC", "score": 1, "type": null, "tokenized_content": [2, 21525, 3, 1925, 2502, 15826, 1927, 3594, 2014, 15335, 4152, 2007, 6571, 21148, 1954, 24218, 5458, 2810, 1942, 4293, 1942, 3793, 2960, 3165, 14551, 3]}]}
{"query": {"id": "q_4962", "content": "vincristine [SEP] ively, in model of diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy was investigated. METHODS: The changes in p", "tokenized_content": [2, 25446, 3, 4370, 2264, 16, 1922, 2322, 1927, 6152, 12, 26492, 17, 2719, 13, 1930, 6161, 12, 25446, 17, 2719, 13, 13177, 1982, 3845, 18, 2860, 30, 1920, 2840, 1922, 3]}, "items": [{"id": "p_4962", "content": "Vincristine [SEP] Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)\n    ", "score": 1, "type": null, "tokenized_content": [2, 25446, 3, 11775, 29951, 3937, 2037, 24198, 1019, 13679, 1019, 18, 12, 14556, 16, 2513, 1963, 3347, 18, 13, 3]}]}
{"query": {"id": "q_4963", "content": "des-Arg10HOE 140 [SEP] but not L-NIL intensify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies sugg", "tokenized_content": [2, 2270, 17, 4582, 2930, 10647, 1021, 8949, 3, 2308, 2084, 54, 17, 20282, 14449, 5169, 12946, 2085, 6014, 2286, 1935, 2455, 1927, 6673, 1021, 8949, 2014, 2270, 17, 4582, 2930, 3]}, "items": [{"id": "p_4963", "content": "HOE 140, desArg(10)- [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 6673, 1021, 8949, 16, 2270, 2419, 12, 2119, 13, 17, 3, 3]}]}
{"query": {"id": "q_4964", "content": "toxic neuropathy [SEP] ify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 r", "tokenized_content": [2, 6161, 13177, 3, 2647, 1012, 12946, 2085, 6014, 2286, 1935, 2455, 1927, 6673, 1021, 8949, 2014, 2270, 17, 4582, 2930, 10647, 1021, 8949, 1922, 6161, 13177, 18, 4355, 30, 2274, 3]}, "items": [{"id": "p_4964", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_4965", "content": "streptozotocin [SEP] g10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy was investi", "tokenized_content": [2, 26492, 3, 8533, 1008, 6673, 1021, 8949, 12, 3895, 11087, 19, 3621, 5416, 13, 2763, 16, 1922, 2322, 1927, 6152, 12, 26492, 17, 2719, 13, 1930, 6161, 12, 25446, 17, 3]}, "items": [{"id": "p_4965", "content": "Streptozocin [SEP] An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in expe", "score": 1, "type": null, "tokenized_content": [2, 25518, 11778, 3, 1925, 7267, 1988, 1977, 4152, 2007, 5044, 4575, 14930, 3707, 28216, 20768, 1036, 18, 2176, 1977, 2251, 1966, 1925, 29128, 9969, 5899, 1930, 1942, 4769, 4032, 1922, 2887, 1021, 3]}]}
{"query": {"id": "q_4966", "content": "neuropathic pain [SEP] s and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care.", "tokenized_content": [2, 16591, 3594, 3, 61, 1930, 2239, 8921, 4472, 2112, 1998, 3655, 1922, 12054, 1943, 1927, 16591, 3594, 16, 3385, 1922, 3461, 2859, 18, 3]}, "items": [{"id": "p_4966", "content": "Neuralgia [SEP] Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5181, 11966, 3, 10702, 2014, 3546, 1941, 3594, 1988, 5110, 4231, 1920, 4914, 2014, 3282, 1927, 43, 5009, 2014, 13598, 5507, 18, 3]}]}
{"query": {"id": "q_4967", "content": "Cardiac toxicity [SEP] Cardiac toxicity observed in association with high-dose cyclophosphamide-based c", "tokenized_content": [2, 4435, 5532, 3, 4435, 5532, 2528, 1922, 3279, 1956, 2149, 17, 3253, 17135, 17, 2454, 45, 3]}, "items": [{"id": "p_4967", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4968", "content": "cyclophosphamide [SEP] Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer.", "tokenized_content": [2, 17135, 3, 4435, 5532, 2528, 1922, 3279, 1956, 2149, 17, 3253, 17135, 17, 2454, 5318, 1958, 6476, 3739, 2539, 18, 3]}, "items": [{"id": "p_4968", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4969", "content": "breast cancer [SEP] th high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer.", "tokenized_content": [2, 3739, 2539, 3, 1913, 2149, 17, 3253, 17135, 17, 2454, 5318, 1958, 6476, 3739, 2539, 18, 3]}, "items": [{"id": "p_4969", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_4970", "content": "Cyclophosphamide [SEP] INTRODUCTION: Cyclophosphamide is an alkylating agent given frequently as a component of many ", "tokenized_content": [2, 17135, 3, 6935, 30, 17135, 1977, 1925, 28912, 5899, 3258, 5467, 1966, 43, 4594, 1927, 3086, 3]}, "items": [{"id": "p_4970", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4971", "content": "toxicity [SEP] ing regimens. In high doses, its nonhematological dose-limiting toxicity is cardiomyopathy. STUDY DESIGN: We combined paclitaxel, melpha", "tokenized_content": [2, 5532, 3, 30393, 9922, 18, 1922, 2149, 5312, 16, 2496, 16925, 9900, 2477, 3253, 17, 8051, 5532, 1977, 14141, 18, 2161, 3036, 30, 2038, 4252, 12404, 16, 4221, 4151, 3]}, "items": [{"id": "p_4971", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_4972", "content": "cardiomyopathy [SEP] . In high doses, its nonhematological dose-limiting toxicity is cardiomyopathy. STUDY DESIGN: We combined paclitaxel, melphalan and high-dose ", "tokenized_content": [2, 14141, 3, 18, 1922, 2149, 5312, 16, 2496, 16925, 9900, 2477, 3253, 17, 8051, 5532, 1977, 14141, 18, 2161, 3036, 30, 2038, 4252, 12404, 16, 4221, 6256, 1928, 1930, 2149, 3]}, "items": [{"id": "p_4972", "content": "Cardiomyopathies [SEP] A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classifi", "score": 1, "type": null, "tokenized_content": [2, 8291, 16038, 3, 43, 2210, 1927, 3902, 1922, 2154, 1920, 6379, 5961, 1977, 1920, 5668, 1927, 1920, 4435, 3760, 6999, 18, 8291, 16038, 2032, 2921, 1974, 1033, 3]}]}
{"query": {"id": "q_4973", "content": "paclitaxel [SEP] -limiting toxicity is cardiomyopathy. STUDY DESIGN: We combined paclitaxel, melphalan and high-dose cyclophosphamide, thiotepa, and carbop", "tokenized_content": [2, 12404, 3, 17, 8051, 5532, 1977, 14141, 18, 2161, 3036, 30, 2038, 4252, 12404, 16, 4221, 6256, 1928, 1930, 2149, 17, 3253, 17135, 16, 15331, 22329, 1019, 16, 1930, 3697, 3]}, "items": [{"id": "p_4973", "content": "Paclitaxel [SEP] A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized ", "score": 1, "type": null, "tokenized_content": [2, 12404, 3, 43, 17009, 3695, 8337, 1021, 3937, 2037, 1920, 18399, 1927, 1920, 14148, 5293, 1018, 6694, 16, 6104, 1957, 3022, 2165, 25203, 1019, 18, 2176, 19658, 12444, 1922, 2310, 27855, 3]}]}
{"query": {"id": "q_4974", "content": "melphalan [SEP] xicity is cardiomyopathy. STUDY DESIGN: We combined paclitaxel, melphalan and high-dose cyclophosphamide, thiotepa, and carboplatin in a ", "tokenized_content": [2, 4221, 6256, 1928, 3, 11551, 3349, 3145, 1977, 14141, 18, 2161, 3036, 30, 2038, 4252, 12404, 16, 4221, 6256, 1928, 1930, 2149, 17, 3253, 17135, 16, 15331, 22329, 1019, 16, 3]}, "items": [{"id": "p_4974", "content": "Melphalan [SEP] An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture", "score": 1, "type": null, "tokenized_content": [2, 4221, 6256, 1928, 3, 1925, 28912, 6634, 4902, 2211, 1988, 1977, 2251, 1966, 1925, 29128, 9969, 1922, 1920, 2386, 1927, 1920, 30129, 15348, 17, 4221, 6256, 1928, 16, 1920, 7442, 4913, 5515, 3]}]}
{"query": {"id": "q_4975", "content": "cyclophosphamide [SEP] . STUDY DESIGN: We combined paclitaxel, melphalan and high-dose cyclophosphamide, thiotepa, and carboplatin in a triple sequential high-dose reg", "tokenized_content": [2, 17135, 3, 18, 2161, 3036, 30, 2038, 4252, 12404, 16, 4221, 6256, 1928, 1930, 2149, 17, 3253, 17135, 16, 15331, 22329, 1019, 16, 1930, 20072, 1922, 43, 10073, 9454, 2149, 3]}, "items": [{"id": "p_4975", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_4976", "content": "thiotepa [SEP]  combined paclitaxel, melphalan and high-dose cyclophosphamide, thiotepa, and carboplatin in a triple sequential high-dose regimen for p", "tokenized_content": [2, 15331, 22329, 1019, 3, 4252, 12404, 16, 4221, 6256, 1928, 1930, 2149, 17, 3253, 17135, 16, 15331, 22329, 1019, 16, 1930, 20072, 1922, 43, 10073, 9454, 2149, 17, 3253, 8607, 3]}, "items": [{"id": "p_4976", "content": "Thiotepa [SEP] A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone m", "score": 1, "type": null, "tokenized_content": [2, 15331, 22329, 1019, 3, 43, 3345, 6161, 28912, 29128, 9969, 5899, 2222, 2251, 1966, 1925, 11422, 4987, 19167, 4905, 18, 2176, 5092, 4407, 16, 8375, 16, 7520, 16, 1930, 3622, 55, 3]}]}
{"query": {"id": "q_4977", "content": "carboplatin [SEP] itaxel, melphalan and high-dose cyclophosphamide, thiotepa, and carboplatin in a triple sequential high-dose regimen for patients with meta", "tokenized_content": [2, 20072, 3, 2176, 10031, 16, 4221, 6256, 1928, 1930, 2149, 17, 3253, 17135, 16, 15331, 22329, 1019, 16, 1930, 20072, 1922, 43, 10073, 9454, 2149, 17, 3253, 8607, 1958, 2132, 3]}, "items": [{"id": "p_4977", "content": "Carboplatin [SEP] An organoplatinum compound that possesses antineoplastic activity.\n    ", "score": 1, "type": null, "tokenized_content": [2, 20072, 3, 1925, 3090, 19371, 1989, 3547, 1988, 14465, 29128, 9969, 2455, 18, 3]}]}
{"query": {"id": "q_4978", "content": "breast cancer [SEP] riple sequential high-dose regimen for patients with metastatic breast cancer. Analysis was performed on 61 women with chemotherapy-responsiv", "tokenized_content": [2, 3739, 2539, 3, 8936, 1952, 9454, 2149, 17, 3253, 8607, 1958, 2132, 1956, 6476, 3739, 2539, 18, 2333, 1982, 2593, 1990, 5473, 3089, 1956, 5318, 17, 2364, 2068, 3]}, "items": [{"id": "p_4978", "content": "Breast Neoplasms [SEP] Tumors or cancer of the human BREAST.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3739, 15347, 3, 3861, 2014, 2539, 1927, 1920, 2616, 3739, 18, 3]}]}
{"query": {"id": "q_4979", "content": "congestive heart failure [SEP] egimen to assess association between presence of peritransplant congestive heart failure (CHF) and the following pretreatment characteristics: presence ", "tokenized_content": [2, 20180, 4003, 4574, 3, 7282, 11593, 1022, 1942, 2634, 3279, 2192, 2990, 1927, 2953, 5412, 4043, 20180, 4003, 4574, 12, 18307, 13, 1930, 1920, 2894, 9111, 3779, 30, 2990, 3]}, "items": [{"id": "p_4979", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4980", "content": "CHF [SEP] on between presence of peritransplant congestive heart failure (CHF) and the following pretreatment characteristics: presence of el", "tokenized_content": [2, 18307, 3, 1990, 2192, 2990, 1927, 2953, 5412, 4043, 20180, 4003, 4574, 12, 18307, 13, 1930, 1920, 2894, 9111, 3779, 30, 2990, 1927, 2349, 3]}, "items": [{"id": "p_4980", "content": "Heart Failure [SEP] A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Hear", "score": 1, "type": null, "tokenized_content": [2, 4003, 4574, 3, 43, 8538, 2625, 1922, 2154, 1920, 4003, 1977, 8082, 1942, 8912, 2397, 5409, 2877, 1942, 9572, 1920, 4487, 2942, 1927, 1920, 3362, 18, 3563, 3]}]}
{"query": {"id": "q_4981", "content": "hypertension [SEP] istics: presence of electrocardiogram (EKG) abnormalities, age, hypertension, prior cardiac history, smoking, diabetes mellitus, prior use o", "tokenized_content": [2, 5579, 3, 1977, 2837, 30, 2990, 1927, 22477, 12, 20529, 1029, 13, 6754, 16, 2632, 16, 5579, 16, 3432, 4435, 4403, 16, 5075, 16, 4032, 9695, 16, 3432, 2485, 57, 3]}, "items": [{"id": "p_4981", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_4982", "content": "diabetes mellitus [SEP] normalities, age, hypertension, prior cardiac history, smoking, diabetes mellitus, prior use of anthracyclines, and left-sided chest irradiation.", "tokenized_content": [2, 4032, 9695, 3, 2791, 2569, 16, 2632, 16, 5579, 16, 3432, 4435, 4403, 16, 5075, 16, 4032, 9695, 16, 3432, 2485, 1927, 30021, 1036, 16, 1930, 3506, 17, 11175, 8475, 3]}, "items": [{"id": "p_4982", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_4983", "content": "anthracyclines [SEP] prior cardiac history, smoking, diabetes mellitus, prior use of anthracyclines, and left-sided chest irradiation. RESULTS: Six of 61 women (10", "tokenized_content": [2, 30021, 1036, 3, 3432, 4435, 4403, 16, 5075, 16, 4032, 9695, 16, 3432, 2485, 1927, 30021, 1036, 16, 1930, 3506, 17, 11175, 8475, 7759, 18, 2274, 30, 3798, 1927, 5473, 3]}, "items": [{"id": "p_4983", "content": "Anthracyclines [SEP] Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daun", "score": 1, "type": null, "tokenized_content": [2, 30021, 1036, 3, 6805, 4300, 1988, 2162, 43, 21196, 2175, 2102, 1963, 2431, 5300, 7253, 6335, 3170, 8765, 2007, 43, 7533, 12546, 8611, 1942, 1920, 3835, 9523, 3692, 1983, 3]}]}
{"query": {"id": "q_4984", "content": "cardiac toxicity [SEP] raction of 31%. Incidence of transient cyclophosphamide-related cardiac toxicity (10%) is comparable to previous recorded literature. Older age ", "tokenized_content": [2, 4435, 5532, 3, 7195, 1929, 1927, 3470, 9, 18, 4332, 1927, 6809, 17135, 17, 2712, 4435, 5532, 12, 2119, 9, 13, 1977, 5596, 1942, 2555, 4562, 4431, 18, 4706, 2632, 3]}, "items": [{"id": "p_4984", "content": "Cardiotoxicity [SEP] Damage to the heart or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY;", "score": 1, "type": null, "tokenized_content": [2, 30490, 3, 4293, 1942, 1920, 4003, 2014, 2496, 2347, 4067, 1942, 3395, 1942, 6161, 10054, 2427, 1966, 4195, 2251, 1922, 5318, 31, 12748, 31, 3]}]}
{"query": {"id": "q_4985", "content": "carbamazepine [SEP] Inappropriate use of carbamazepine and vigabatrin in typical absence seizures.", "tokenized_content": [2, 30315, 3, 13770, 2485, 1927, 30315, 1930, 11505, 20013, 17670, 1922, 5939, 3905, 10060, 18, 3]}, "items": [{"id": "p_4985", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_4986", "content": "vigabatrin [SEP] Inappropriate use of carbamazepine and vigabatrin in typical absence seizures.", "tokenized_content": [2, 11505, 20013, 17670, 3, 13770, 2485, 1927, 30315, 1930, 11505, 20013, 17670, 1922, 5939, 3905, 10060, 18, 3]}, "items": [{"id": "p_4986", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_4987", "content": "absence seizures [SEP] Inappropriate use of carbamazepine and vigabatrin in typical absence seizures.", "tokenized_content": [2, 3905, 10060, 3, 13770, 2485, 1927, 30315, 1930, 11505, 20013, 17670, 1922, 5939, 3905, 10060, 18, 3]}, "items": [{"id": "p_4987", "content": "Epilepsy, Absence [SEP] A childhood seizure disorder characterized by rhythmic electrical brain discharges of generalized onset. Clinical features inclu", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 3905, 3, 43, 7238, 11015, 4770, 4378, 2007, 20275, 8287, 3068, 20805, 1927, 9612, 4727, 18, 2535, 4075, 2296, 1032, 3]}]}
{"query": {"id": "q_4988", "content": "Carbamazepine [SEP] Carbamazepine and vigabatrin are contraindicated in typical absence seizures.", "tokenized_content": [2, 30315, 3, 30315, 1930, 11505, 20013, 17670, 2032, 17825, 22171, 1922, 5939, 3905, 10060, 18, 3]}, "items": [{"id": "p_4988", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_4989", "content": "vigabatrin [SEP] Carbamazepine and vigabatrin are contraindicated in typical absence seizures. Of 18 consecut", "tokenized_content": [2, 11505, 20013, 17670, 3, 30315, 1930, 11505, 20013, 17670, 2032, 17825, 22171, 1922, 5939, 3905, 10060, 18, 1927, 2654, 22065, 1031, 3]}, "items": [{"id": "p_4989", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_4990", "content": "absence seizures [SEP] Carbamazepine and vigabatrin are contraindicated in typical absence seizures. Of 18 consecutive referrals of children with resistant typical", "tokenized_content": [2, 3905, 10060, 3, 30315, 1930, 11505, 20013, 17670, 2032, 17825, 22171, 1922, 5939, 3905, 10060, 18, 1927, 2654, 7351, 20439, 1927, 3069, 1956, 4910, 5939, 3]}, "items": [{"id": "p_4990", "content": "Epilepsy, Absence [SEP] A childhood seizure disorder characterized by rhythmic electrical brain discharges of generalized onset. Clinical features inclu", "score": 1, "type": null, "tokenized_content": [2, 9741, 16, 3905, 3, 43, 7238, 11015, 4770, 4378, 2007, 20275, 8287, 3068, 20805, 1927, 9612, 4727, 18, 2535, 4075, 2296, 1032, 3]}]}
{"query": {"id": "q_4991", "content": "carbamazepine [SEP] tant typical absences only, eight were erroneously treated with carbamazepine either as monotherapy or as an add-on. Vigabatrin was also used", "tokenized_content": [2, 30315, 3, 10434, 1031, 5939, 3905, 1036, 2444, 16, 5066, 1985, 26174, 1954, 2868, 1956, 30315, 3108, 1966, 13767, 2014, 1966, 1925, 3019, 17, 1990, 18, 11505, 20013, 17670, 1982, 3]}, "items": [{"id": "p_4991", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_4992", "content": "Vigabatrin [SEP] eated with carbamazepine either as monotherapy or as an add-on. Vigabatrin was also used in the treatment of two children. Frequency of ab", "tokenized_content": [2, 11505, 20013, 17670, 3, 13619, 1919, 1956, 30315, 3108, 1966, 13767, 2014, 1966, 1925, 3019, 17, 1990, 18, 11505, 20013, 17670, 1982, 2222, 2251, 1922, 1920, 2311, 1927, 2288, 3069, 3]}, "items": [{"id": "p_4992", "content": "Vigabatrin [SEP] An analogue of GAMMA-AMINOBUTYRIC ACID. It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible ", "score": 1, "type": null, "tokenized_content": [2, 11505, 20013, 17670, 3, 1925, 12980, 1927, 7034, 17, 29093, 2687, 18, 2176, 1977, 1925, 14104, 4106, 1927, 24, 17, 3835, 16119, 16128, 24376, 16, 1920, 4113, 5061, 3]}]}
{"query": {"id": "q_4993", "content": "myoclonic jerks [SEP]  children treated with carbamazepine and two of these developed myoclonic jerks, which resolved on withdrawal of carbamazepine. Absences were a", "tokenized_content": [2, 15924, 2223, 3490, 26482, 5297, 3, 3069, 2868, 1956, 30315, 1930, 2288, 1927, 2144, 3530, 15924, 2223, 3490, 26482, 5297, 16, 2154, 8397, 1990, 9594, 1927, 30315, 18, 3905, 1036, 3]}, "items": [{"id": "p_4993", "content": "Myoclonus [SEP] Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscle", "score": 1, "type": null, "tokenized_content": [2, 15924, 2223, 1916, 1957, 3, 28493, 7418, 17, 3189, 15465, 16, 11499, 1922, 11529, 1930, 6531, 16, 3489, 2007, 9157, 16, 1927, 43, 3760, 2014, 43, 2210, 1927, 3760, 3]}]}
{"query": {"id": "q_4994", "content": "sodium valproate [SEP] nt treatment. Optimal control of the absences was achieved with sodium valproate, lamotrigine, or ethosuximide alone or in combination.", "tokenized_content": [2, 5227, 23867, 2010, 3, 5891, 2311, 18, 5419, 2285, 1927, 1920, 3905, 1036, 1982, 5032, 1956, 5227, 23867, 2010, 16, 8282, 18935, 26296, 1021, 16, 2014, 3293, 1951, 8640, 16352, 3]}, "items": [{"id": "p_4994", "content": "Valproic Acid [SEP] A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not", "score": 1, "type": null, "tokenized_content": [2, 23867, 1935, 2687, 3, 43, 5934, 2687, 1956, 26572, 2031, 3879, 2251, 1922, 1920, 2311, 1927, 9741, 18, 1920, 3531, 1927, 2496, 4272, 7728, 2032, 2084, 3]}]}
{"query": {"id": "q_4995", "content": "lamotrigine [SEP] mal control of the absences was achieved with sodium valproate, lamotrigine, or ethosuximide alone or in combination.", "tokenized_content": [2, 8282, 18935, 26296, 1021, 3, 3054, 2285, 1927, 1920, 3905, 1036, 1982, 5032, 1956, 5227, 23867, 2010, 16, 8282, 18935, 26296, 1021, 16, 2014, 3293, 1951, 8640, 16352, 4298, 2014, 3]}, "items": [{"id": "p_4995", "content": "lamotrigine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8282, 18935, 26296, 1021, 3, 3]}]}
{"query": {"id": "q_4996", "content": "ethosuximide [SEP] he absences was achieved with sodium valproate, lamotrigine, or ethosuximide alone or in combination.", "tokenized_content": [2, 3293, 1951, 8640, 16352, 3, 2234, 3905, 1036, 1982, 5032, 1956, 5227, 23867, 2010, 16, 8282, 18935, 26296, 1021, 16, 2014, 3293, 1951, 8640, 16352, 4298, 2014, 1922, 3921, 18, 3]}, "items": [{"id": "p_4996", "content": "Ethosuximide [SEP] An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3293, 1951, 8640, 16352, 3, 1925, 26572, 2031, 4369, 4707, 1922, 1920, 2311, 1927, 3905, 10060, 26844, 2437, 4617, 8150, 1919, 2007, 2303, 3584, 1927, 10060, 18, 3]}]}
{"query": {"id": "q_4997", "content": "Hemolytic anemia [SEP] Hemolytic anemia associated with the use of omeprazole.", "tokenized_content": [2, 21515, 10679, 3, 21515, 10679, 2458, 1956, 1920, 2485, 1927, 12453, 26252, 18, 3]}, "items": [{"id": "p_4997", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_4998", "content": "omeprazole [SEP] Hemolytic anemia associated with the use of omeprazole.", "tokenized_content": [2, 12453, 26252, 3, 21515, 10679, 2458, 1956, 1920, 2485, 1927, 12453, 26252, 18, 3]}, "items": [{"id": "p_4998", "content": "Omeprazole [SEP] A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS ", "score": 1, "type": null, "tokenized_content": [2, 12453, 26252, 3, 43, 24, 17, 17954, 17, 23, 16, 25, 17, 9780, 18425, 19743, 16, 25, 17, 17954, 13058, 28950, 10533, 1927, 2267, 11921, 6984, 1988, 1977, 2251, 1922, 1920, 3181, 1927, 11399, 16225, 3]}]}
{"query": {"id": "q_4999", "content": "Omeprazole [SEP] Omeprazole is the first drug designed to block the final step in the acid ", "tokenized_content": [2, 12453, 26252, 3, 12453, 26252, 1977, 1920, 2561, 2838, 4609, 1942, 3367, 1920, 3948, 3537, 1922, 1920, 2687, 3]}, "items": [{"id": "p_4999", "content": "Omeprazole [SEP] A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS ", "score": 1, "type": null, "tokenized_content": [2, 12453, 26252, 3, 43, 24, 17, 17954, 17, 23, 16, 25, 17, 9780, 18425, 19743, 16, 25, 17, 17954, 13058, 28950, 10533, 1927, 2267, 11921, 6984, 1988, 1977, 2251, 1922, 1920, 3181, 1927, 11399, 16225, 3]}]}
{"query": {"id": "q_5000", "content": "peptic ulcer disease [SEP] It has been shown to be extremely effective in the treatment of peptic ulcer disease, reflux esophagitis, and the Zollinger-Ellison syndrome. Althou", "tokenized_content": [2, 29488, 10096, 2573, 3, 2176, 2258, 2252, 2522, 1942, 1998, 8113, 3655, 1922, 1920, 2311, 1927, 29488, 10096, 2573, 16, 13583, 12901, 3678, 16, 1930, 1920, 21483, 3961, 1915, 17, 3]}, "items": [{"id": "p_5000", "content": "Peptic Ulcer [SEP] Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and ", "score": 1, "type": null, "tokenized_content": [2, 29488, 10096, 3, 10096, 1988, 5110, 1922, 1920, 3451, 1927, 1920, 8375, 6482, 2154, 10449, 2460, 5217, 1956, 6319, 17574, 3165, 27979, 1930, 3]}]}
{"query": {"id": "q_5001", "content": "reflux esophagitis [SEP] e extremely effective in the treatment of peptic ulcer disease, reflux esophagitis, and the Zollinger-Ellison syndrome. Although clinical experien", "tokenized_content": [2, 13583, 12901, 3678, 3, 47, 8113, 3655, 1922, 1920, 2311, 1927, 29488, 10096, 2573, 16, 13583, 12901, 3678, 16, 1930, 1920, 21483, 3961, 1915, 17, 20430, 8142, 4741, 18, 2876, 3]}, "items": [{"id": "p_5001", "content": "Gastroesophageal Reflux [SEP] Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGU", "score": 1, "type": null, "tokenized_content": [2, 28933, 13583, 3, 14492, 3426, 1927, 6319, 17574, 12, 6319, 2687, 13, 1930, 19, 2014, 17752, 8906, 12, 9619, 4576, 31, 6356, 17574, 13, 2460, 1920, 6583, 12901, 1032, 3]}]}
{"query": {"id": "q_5002", "content": "Zollinger-Ellison syndrome [SEP]  treatment of peptic ulcer disease, reflux esophagitis, and the Zollinger-Ellison syndrome. Although clinical experience with omeprazole is still limited,", "tokenized_content": [2, 21483, 3961, 1915, 17, 20430, 8142, 4741, 3, 2311, 1927, 29488, 10096, 2573, 16, 13583, 12901, 3678, 16, 1930, 1920, 21483, 3961, 1915, 17, 20430, 8142, 4741, 18, 2876, 2535, 3]}, "items": [{"id": "p_5002", "content": "Zollinger-Ellison Syndrome [SEP] A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumo", "score": 1, "type": null, "tokenized_content": [2, 21483, 3961, 1915, 17, 20430, 8142, 4741, 3, 43, 4741, 1988, 1977, 4378, 2007, 1920, 21845, 1927, 4010, 29488, 10096, 16, 10694, 1940, 10411, 2001, 1927, 6319, 2687, 16, 1930, 27051, 17, 7144, 2497, 1037, 3]}]}
{"query": {"id": "q_5003", "content": "omeprazole [SEP] e Zollinger-Ellison syndrome. Although clinical experience with omeprazole is still limited, many controlled studies have established the ", "tokenized_content": [2, 12453, 26252, 3, 47, 21483, 3961, 1915, 17, 20430, 8142, 4741, 18, 2876, 2535, 4848, 1956, 12453, 26252, 1977, 3974, 3892, 16, 3086, 4642, 2351, 2162, 4379, 1920, 3]}, "items": [{"id": "p_5003", "content": "Omeprazole [SEP] A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS ", "score": 1, "type": null, "tokenized_content": [2, 12453, 26252, 3, 43, 24, 17, 17954, 17, 23, 16, 25, 17, 9780, 18425, 19743, 16, 25, 17, 17954, 13058, 28950, 10533, 1927, 2267, 11921, 6984, 1988, 1977, 2251, 1922, 1920, 3181, 1927, 11399, 16225, 3]}]}
{"query": {"id": "q_5004", "content": "hemolytic anemia [SEP] serious short-term adverse reaction with the use of omeprazole: hemolytic anemia. The patient developed weakness, lethargy, and shortness of bre", "tokenized_content": [2, 21515, 10679, 3, 7433, 3662, 17, 2576, 5246, 3227, 1956, 1920, 2485, 1927, 12453, 26252, 30, 21515, 10679, 18, 1920, 2774, 3530, 12175, 16, 8381, 2419, 1012, 16, 1930, 3662, 3]}, "items": [{"id": "p_5004", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_5005", "content": "lethargy [SEP] f omeprazole: hemolytic anemia. The patient developed weakness, lethargy, and shortness of breath 2 days after starting therapy with ome", "tokenized_content": [2, 8381, 2419, 1012, 3, 48, 12453, 26252, 30, 21515, 10679, 18, 1920, 2774, 3530, 12175, 16, 8381, 2419, 1012, 16, 1930, 3662, 2971, 1927, 8735, 22, 3000, 2256, 6801, 3181, 3]}, "items": [{"id": "p_5005", "content": "Lethargy [SEP] A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simp", "score": 1, "type": null, "tokenized_content": [2, 8381, 2419, 1012, 3, 43, 3335, 3360, 1927, 25387, 6121, 6150, 2971, 16, 6069, 5427, 16, 2014, 18191, 10008, 2013, 16, 1956, 3301, 16661, 1919, 16, 1930, 4537, 8791, 2587, 2287, 1930, 12979, 2328, 1034, 3]}]}
{"query": {"id": "q_5006", "content": "shortness of breath [SEP] hemolytic anemia. The patient developed weakness, lethargy, and shortness of breath 2 days after starting therapy with omeprazole. Two weeks after ", "tokenized_content": [2, 3662, 2971, 1927, 8735, 3, 21515, 10679, 18, 1920, 2774, 3530, 12175, 16, 8381, 2419, 1012, 16, 1930, 3662, 2971, 1927, 8735, 22, 3000, 2256, 6801, 3181, 1956, 12453, 26252, 3]}, "items": [{"id": "p_5006", "content": "Dyspnea [SEP] Difficult or labored breathing.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18461, 3, 4571, 2014, 3876, 1919, 11995, 18, 3]}]}
{"query": {"id": "q_5007", "content": "bilirubin [SEP] sitive direct Coombs antiglobulin test and an elevated indirect bilirubin. After she discontinued the omeprazole, her hemoglobin and hema", "tokenized_content": [2, 15702, 3, 14949, 2320, 3083, 18601, 2083, 2246, 27583, 2648, 1930, 1925, 4664, 6354, 15702, 18, 2256, 4693, 16087, 1920, 12453, 26252, 16, 3656, 9652, 1930, 3243, 1019, 3]}, "items": [{"id": "p_5007", "content": "Bilirubin [SEP] A bile pigment that is a degradation product of HEME.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15702, 3, 43, 9619, 12905, 1988, 1977, 43, 4877, 4863, 1927, 10954, 18, 3]}]}
{"query": {"id": "q_5008", "content": "toxicity [SEP] The use and toxicity of didanosine (ddI) in HIV antibody-positive individuals intole", "tokenized_content": [2, 5532, 3, 1920, 2485, 1930, 5532, 1927, 2811, 9286, 6777, 1021, 12, 6758, 1033, 13, 1922, 3525, 3533, 17, 2843, 3445, 2460, 1952, 3]}, "items": [{"id": "p_5008", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_5009", "content": "didanosine [SEP] The use and toxicity of didanosine (ddI) in HIV antibody-positive individuals intolerant to zidovu", "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 1920, 2485, 1930, 5532, 1927, 2811, 9286, 6777, 1021, 12, 6758, 1033, 13, 1922, 3525, 3533, 17, 2843, 3445, 16193, 2031, 1942, 28666, 22389, 1020, 3]}, "items": [{"id": "p_5009", "content": "Didanosine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modificatio", "score": 1, "type": null, "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 43, 6201, 18, 2052, 2157, 2077, 1968, 1037, 3]}]}
{"query": {"id": "q_5010", "content": "ddI [SEP] The use and toxicity of didanosine (ddI) in HIV antibody-positive individuals intolerant to zidovudine ", "tokenized_content": [2, 6758, 1033, 3, 1920, 2485, 1930, 5532, 1927, 2811, 9286, 6777, 1021, 12, 6758, 1033, 13, 1922, 3525, 3533, 17, 2843, 3445, 16193, 2031, 1942, 28666, 22389, 1020, 20597, 3]}, "items": [{"id": "p_5010", "content": "Didanosine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modificatio", "score": 1, "type": null, "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 43, 6201, 18, 2052, 2157, 2077, 1968, 1037, 3]}]}
{"query": {"id": "q_5011", "content": "HIV antibody-positive [SEP] The use and toxicity of didanosine (ddI) in HIV antibody-positive individuals intolerant to zidovudine (AZT)", "tokenized_content": [2, 3525, 3533, 17, 2843, 3, 1920, 2485, 1930, 5532, 1927, 2811, 9286, 6777, 1021, 12, 6758, 1033, 13, 1922, 3525, 3533, 17, 2843, 3445, 16193, 2031, 1942, 28666, 22389, 1020, 3]}, "items": [{"id": "p_5011", "content": "HIV Infections [SEP] Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related ", "score": 1, "type": null, "tokenized_content": [2, 3525, 5024, 3, 5921, 1920, 5648, 1927, 2616, 13141, 3413, 5024, 1988, 3109, 2037, 9978, 28781, 16, 8481, 1032, 8494, 17, 2712, 3]}]}
{"query": {"id": "q_5012", "content": "zidovudine [SEP] nosine (ddI) in HIV antibody-positive individuals intolerant to zidovudine (AZT)", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 9291, 2053, 12, 6758, 1033, 13, 1922, 3525, 3533, 17, 2843, 3445, 16193, 2031, 1942, 28666, 22389, 1020, 20597, 12, 28301, 13, 3]}, "items": [{"id": "p_5012", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_5013", "content": "AZT [SEP]  in HIV antibody-positive individuals intolerant to zidovudine (AZT)", "tokenized_content": [2, 28301, 3, 1922, 3525, 3533, 17, 2843, 3445, 16193, 2031, 1942, 28666, 22389, 1020, 20597, 12, 28301, 13, 3]}, "items": [{"id": "p_5013", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_5014", "content": "zidovudine [SEP] One hundred and fifty-one patients intolerant to zidovudine (AZT) received didanosine (ddI) to a maximum dose of 12.5 mg/kg", "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 2340, 8295, 1930, 12357, 17, 2340, 2132, 16193, 2031, 1942, 28666, 22389, 1020, 20597, 12, 28301, 13, 4004, 2811, 9286, 6777, 1021, 12, 6758, 1033, 3]}, "items": [{"id": "p_5014", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_5015", "content": "AZT [SEP] One hundred and fifty-one patients intolerant to zidovudine (AZT) received didanosine (ddI) to a maximum dose of 12.5 mg/kg/day.", "tokenized_content": [2, 28301, 3, 2340, 8295, 1930, 12357, 17, 2340, 2132, 16193, 2031, 1942, 28666, 22389, 1020, 20597, 12, 28301, 13, 4004, 2811, 9286, 6777, 1021, 12, 6758, 1033, 13, 1942, 43, 3]}, "items": [{"id": "p_5015", "content": "Zidovudine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modific", "score": 1, "type": null, "tokenized_content": [2, 28666, 22389, 1020, 20597, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 1925, 6352, 15072, 2210, 18, 2052, 2157, 2077, 3]}]}
{"query": {"id": "q_5016", "content": "didanosine [SEP]  and fifty-one patients intolerant to zidovudine (AZT) received didanosine (ddI) to a maximum dose of 12.5 mg/kg/day. Patient response was", "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 1930, 12357, 17, 2340, 2132, 16193, 2031, 1942, 28666, 22389, 1020, 20597, 12, 28301, 13, 4004, 2811, 9286, 6777, 1021, 12, 6758, 1033, 13, 1942, 3]}, "items": [{"id": "p_5016", "content": "Didanosine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modificatio", "score": 1, "type": null, "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 43, 6201, 18, 2052, 2157, 2077, 1968, 1037, 3]}]}
{"query": {"id": "q_5017", "content": "ddI [SEP] ne patients intolerant to zidovudine (AZT) received didanosine (ddI) to a maximum dose of 12.5 mg/kg/day. Patient response was asse", "tokenized_content": [2, 6758, 1033, 3, 2069, 2132, 16193, 2031, 1942, 28666, 22389, 1020, 20597, 12, 28301, 13, 4004, 2811, 9286, 6777, 1021, 12, 6758, 1033, 13, 1942, 43, 4419, 3253, 1927, 2369, 3]}, "items": [{"id": "p_5017", "content": "Didanosine [SEP] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modificatio", "score": 1, "type": null, "tokenized_content": [2, 2811, 9286, 6777, 1021, 3, 43, 2811, 1021, 7221, 1022, 2626, 8028, 3547, 1922, 2154, 1920, 23, 11, 17, 8275, 2210, 1990, 1920, 9523, 11804, 2258, 2252, 8403, 2007, 43, 6201, 18, 2052, 2157, 2077, 1968, 1037, 3]}]}
{"query": {"id": "q_5018", "content": "opportunistic infections [SEP] , weight, and quality of life. Seventy patients developed major opportunistic infections whilst on therapy; this was the first AIDS diagnosis in 17. Onl", "tokenized_content": [2, 19169, 5024, 3, 16, 3388, 16, 1930, 3455, 1927, 3308, 18, 16270, 2132, 3530, 3044, 19169, 5024, 12126, 1990, 3181, 31, 2052, 1982, 1920, 2561, 8494, 3574, 1922, 2752, 18, 3]}, "items": [{"id": "p_5018", "content": "Opportunistic Infections [SEP] An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 19169, 5024, 3, 1925, 2909, 4189, 2007, 1925, 9669, 2154, 8272, 8070, 2441, 4908, 2961, 16, 47, 18, 49, 18, 16, 2409, 15858, 18, 3]}]}
{"query": {"id": "q_5019", "content": "AIDS [SEP]  opportunistic infections whilst on therapy; this was the first AIDS diagnosis in 17. Only minor changes in CD4+ lymphocyte subset c", "tokenized_content": [2, 8494, 3, 19169, 5024, 12126, 1990, 3181, 31, 2052, 1982, 1920, 2561, 8494, 3574, 1922, 2752, 18, 2444, 5857, 2840, 1922, 4095, 15, 10009, 6728, 45, 3]}, "items": [{"id": "p_5019", "content": "Acquired Immunodeficiency Syndrome [SEP] An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-ly", "score": 1, "type": null, "tokenized_content": [2, 5815, 13141, 4741, 3, 1925, 5815, 7374, 1927, 3689, 7611, 2458, 1956, 2909, 2007, 1920, 2616, 13141, 3413, 12, 3525, 13, 16, 43, 4095, 17, 2843, 62, 17, 7518, 3]}]}
{"query": {"id": "q_5020", "content": "diarrhoea [SEP] able to didanosine were common. The most common side-effect was diarrhoea, which resulted in cessation of therapy in 19 individuals. Peri", "tokenized_content": [2, 20998, 3, 4236, 1942, 2811, 9286, 6777, 1021, 1985, 3059, 18, 1920, 2501, 3059, 4159, 17, 2495, 1982, 20998, 16, 2154, 4306, 1922, 10975, 1927, 3181, 1922, 2282, 3445, 18, 3]}, "items": [{"id": "p_5020", "content": "Diarrhea [SEP] An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of wa", "score": 1, "type": null, "tokenized_content": [2, 11904, 3, 1925, 2502, 5875, 1999, 2014, 3261, 9592, 1927, 18610, 16, 2427, 1966, 9659, 14839, 18, 12295, 9592, 1977, 2712, 1942, 1920, 3400, 1927, 4114, 3]}]}
{"query": {"id": "q_5021", "content": "Peripheral neuropathy [SEP] hoea, which resulted in cessation of therapy in 19 individuals. Peripheral neuropathy occurred in 12 patients and pancreatitis in six. Thirteen patie", "tokenized_content": [2, 5009, 13177, 3, 6673, 5376, 16, 2154, 4306, 1922, 10975, 1927, 3181, 1922, 2282, 3445, 18, 5009, 13177, 4807, 1922, 2369, 2132, 1930, 14605, 1922, 3798, 18, 18468, 2091, 1021, 3]}, "items": [{"id": "p_5021", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_5022", "content": "pancreatitis [SEP]  individuals. Peripheral neuropathy occurred in 12 patients and pancreatitis in six. Thirteen patients developed a raised serum amylase with", "tokenized_content": [2, 14605, 3, 3445, 18, 5009, 13177, 4807, 1922, 2369, 2132, 1930, 14605, 1922, 3798, 18, 18468, 2132, 3530, 43, 8930, 3256, 19139, 1956, 3]}, "items": [{"id": "p_5022", "content": "Pancreatitis [SEP] INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde", "score": 1, "type": null, "tokenized_content": [2, 14605, 3, 4531, 1927, 1920, 10936, 18, 14605, 1977, 5947, 1966, 3939, 10292, 2276, 2032, 6287, 25035, 2014, 10448, 14492, 3]}]}
{"query": {"id": "q_5023", "content": "abdominal pain [SEP] six. Thirteen patients developed a raised serum amylase without abdominal pain. Seven patients developed glucose tolerance curves characterist", "tokenized_content": [2, 6900, 3594, 3, 3798, 18, 18468, 2132, 3530, 43, 8930, 3256, 19139, 2979, 6900, 3594, 18, 5260, 2132, 3530, 3817, 6555, 6223, 3327, 1031, 3]}, "items": [{"id": "p_5023", "content": "Abdominal Pain [SEP] Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue inju", "score": 1, "type": null, "tokenized_content": [2, 6900, 3594, 3, 15826, 1927, 15335, 16, 8740, 16, 2014, 6024, 1012, 1922, 1920, 6900, 3031, 31, 4933, 2458, 1956, 3183, 4414, 16, 2960, 2831, 1032, 3]}]}
{"query": {"id": "q_5024", "content": "glucose tolerance curves [SEP]  serum amylase without abdominal pain. Seven patients developed glucose tolerance curves characteristic of diabetes but these were mild, did not require", "tokenized_content": [2, 3817, 6555, 6223, 3, 3256, 19139, 2979, 6900, 3594, 18, 5260, 2132, 3530, 3817, 6555, 6223, 6293, 1927, 4032, 2308, 2144, 1985, 5809, 16, 2811, 2084, 4350, 3]}, "items": [{"id": "p_5024", "content": "Glucose Intolerance [SEP] A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above appro", "score": 1, "type": null, "tokenized_content": [2, 3817, 19202, 3, 43, 6598, 3360, 1922, 2154, 2877, 3817, 2237, 1977, 2941, 2254, 3993, 8949, 2786, 19, 2813, 2646, 1927, 3582, 2019, 8712, 16, 1930, 3538, 2440, 3]}]}
{"query": {"id": "q_5025", "content": "diabetes [SEP] n patients developed glucose tolerance curves characteristic of diabetes but these were mild, did not require treatment and returned to ", "tokenized_content": [2, 4032, 3, 56, 2132, 3530, 3817, 6555, 6223, 6293, 1927, 4032, 2308, 2144, 1985, 5809, 16, 2811, 2084, 4350, 2311, 1930, 10418, 1942, 3]}, "items": [{"id": "p_5025", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_5026", "content": "ribavirin [SEP] Can angiogenesis be a target of treatment for ribavirin associated hemolytic anemia?", "tokenized_content": [2, 23635, 3, 2112, 8244, 1998, 43, 2758, 1927, 2311, 1958, 23635, 2458, 21515, 10679, 35, 3]}, "items": [{"id": "p_5026", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_5027", "content": "hemolytic anemia [SEP]  angiogenesis be a target of treatment for ribavirin associated hemolytic anemia?", "tokenized_content": [2, 21515, 10679, 3, 8244, 1998, 43, 2758, 1927, 2311, 1958, 23635, 2458, 21515, 10679, 35, 3]}, "items": [{"id": "p_5027", "content": "Anemia, Hemolytic [SEP] A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red bl", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 21515, 3, 43, 2625, 1927, 11391, 7396, 2312, 2877, 2094, 12, 10679, 13, 2014, 9406, 9652, 2810, 1942, 9839, 12102, 1927, 2312, 2266, 3]}]}
{"query": {"id": "q_5028", "content": "ribavirin [SEP] BACKGROUND/AIMS: Recently ribavirin has been found to inhibit angiogenesis and a number of angiogen", "tokenized_content": [2, 23635, 3, 3872, 19, 8267, 30, 3998, 23635, 2258, 2252, 2435, 1942, 2875, 8244, 1930, 43, 2529, 1927, 29220, 2432, 3]}, "items": [{"id": "p_5028", "content": "Ribavirin [SEP] A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.\n   ", "score": 1, "type": null, "tokenized_content": [2, 23635, 3, 43, 18015, 20330, 9215, 4627, 12191, 2057, 10129, 5899, 1988, 7644, 11079, 2687, 4271, 1930, 1977, 2251, 3316, 2321, 3146, 1930, 2678, 6241, 18, 3]}]}
{"query": {"id": "q_5029", "content": "sunitinib [SEP] it angiogenesis and a number of angiogenesis inhibitors such as sunitinib and sorafenib have been found to cause acute hemolysis. We aime", "tokenized_content": [2, 21458, 3, 2176, 8244, 1930, 43, 2529, 1927, 8244, 4472, 2427, 1966, 21458, 1930, 16788, 2162, 2252, 2435, 1942, 3936, 3939, 22409, 18, 2038, 3774, 1021, 3]}, "items": [{"id": "p_5029", "content": "sunitinib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21458, 3, 3]}]}
{"query": {"id": "q_5030", "content": "sorafenib [SEP] s and a number of angiogenesis inhibitors such as sunitinib and sorafenib have been found to cause acute hemolysis. We aimed to investiga", "tokenized_content": [2, 16788, 3, 61, 1930, 43, 2529, 1927, 8244, 4472, 2427, 1966, 21458, 1930, 16788, 2162, 2252, 2435, 1942, 3936, 3939, 22409, 18, 2038, 6822, 1942, 2772, 1019, 3]}, "items": [{"id": "p_5030", "content": "sorafenib [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16788, 3, 3]}]}
{"query": {"id": "q_5031", "content": "hemolysis [SEP]  such as sunitinib and sorafenib have been found to cause acute hemolysis. We aimed to investigate whether there is a relation between he", "tokenized_content": [2, 22409, 3, 2427, 1966, 21458, 1930, 16788, 2162, 2252, 2435, 1942, 3936, 3939, 22409, 18, 2038, 6822, 1942, 4482, 3053, 2276, 1977, 43, 6147, 2192, 2234, 3]}, "items": [{"id": "p_5031", "content": "Hemolysis [SEP] The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and change", "score": 1, "type": null, "tokenized_content": [2, 22409, 3, 1920, 12102, 1927, 14161, 2007, 3086, 2413, 9263, 4820, 2427, 1966, 3788, 16, 4802, 16, 10164, 16, 3449, 16, 1930, 3185, 3]}]}
{"query": {"id": "q_5032", "content": "anemia [SEP] ch are modifiable and can help in developing strategies against anemia. METHODS: Fourteen patients chronically infected with hepatitis", "tokenized_content": [2, 10679, 3, 2016, 2032, 21743, 1930, 2112, 4087, 1922, 5130, 4762, 3316, 10679, 18, 2860, 30, 18032, 2132, 16132, 4014, 1956, 7977, 3]}, "items": [{"id": "p_5032", "content": "Anemia [SEP] A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 3, 43, 3378, 1922, 1920, 2529, 1927, 7396, 14161, 2014, 1922, 1920, 9988, 1927, 9652, 18, 3]}]}
{"query": {"id": "q_5033", "content": "chronically infected with hepatitis C virus [SEP] eveloping strategies against anemia. METHODS: Fourteen patients chronically infected with hepatitis C virus were treated by pegylated interferon alpha 2a and ribavirin. Se", "tokenized_content": [2, 16132, 4014, 1956, 7977, 45, 3413, 3, 2180, 1938, 2011, 1941, 4762, 3316, 10679, 18, 2860, 30, 18032, 2132, 16132, 4014, 1956, 7977, 45, 3413, 1985, 2868, 2007, 24208, 10001, 3]}, "items": [{"id": "p_5033", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_5034", "content": "pegylated interferon alpha 2a [SEP] nts chronically infected with hepatitis C virus were treated by pegylated interferon alpha 2a and ribavirin. Serum hemoglobin, haptoglobin and angiogenesis m", "tokenized_content": [2, 24208, 10001, 4595, 5251, 3, 17969, 16132, 4014, 1956, 7977, 45, 3413, 1985, 2868, 2007, 24208, 10001, 4595, 5251, 1930, 23635, 18, 3256, 9652, 16, 29683, 7856, 1930, 8244, 55, 3]}, "items": [{"id": "p_5034", "content": "peginterferon alfa-2a [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7404, 9185, 2070, 1916, 26131, 17, 5251, 3, 3]}]}
{"query": {"id": "q_5035", "content": "pegylated interferon [SEP] nts chronically infected with hepatitis C virus were treated by pegylated interferon alpha 2a and ribavirin. Serum hemoglobin, haptoglobin and angio", "tokenized_content": [2, 24208, 10001, 3, 17969, 16132, 4014, 1956, 7977, 45, 3413, 1985, 2868, 2007, 24208, 10001, 4595, 5251, 1930, 23635, 18, 3256, 9652, 16, 29683, 7856, 1930, 29220, 3]}, "items": [{"id": "p_5035", "content": "peginterferon alfa-2b [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7404, 9185, 2070, 1916, 26131, 17, 5751, 3, 3]}]}
{"query": {"id": "q_5036", "content": "hepatitis C [SEP] st anemia. METHODS: Fourteen patients chronically infected with hepatitis C virus were treated by pegylated interferon alpha 2a and ribavir", "tokenized_content": [2, 7977, 45, 3, 1955, 10679, 18, 2860, 30, 18032, 2132, 16132, 4014, 1956, 7977, 45, 3413, 1985, 2868, 2007, 24208, 10001, 4595, 5251, 1930, 5216, 11046, 3]}, "items": [{"id": "p_5036", "content": "Hepatitis C, Chronic [SEP] INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead", "score": 1, "type": null, "tokenized_content": [2, 7977, 45, 16, 3724, 3, 4531, 1927, 1920, 3568, 1922, 5209, 1988, 1977, 4189, 2007, 7977, 45, 3413, 11671, 3798, 3221, 2014, 2253, 18, 3724, 7977, 45, 2112, 2949, 3]}]}
{"query": {"id": "q_5037", "content": "Cocaine [SEP] Cocaine causes memory and learning impairments in rats: involvement of ", "tokenized_content": [2, 9045, 3, 9045, 5092, 4525, 1930, 4809, 12454, 1922, 3615, 30, 5668, 1927, 3]}, "items": [{"id": "p_5037", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_5038", "content": "learning impairments [SEP] Cocaine causes memory and learning impairments in rats: involvement of nuclear factor kappa B and oxidative st", "tokenized_content": [2, 4809, 12454, 3, 9045, 5092, 4525, 1930, 4809, 12454, 1922, 3615, 30, 5668, 1927, 4254, 2991, 12093, 44, 1930, 5163, 1955, 3]}, "items": [{"id": "p_5038", "content": "Learning Disorders [SEP] Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to ", "score": 1, "type": null, "tokenized_content": [2, 4809, 4414, 3, 2961, 4378, 2007, 43, 2228, 12156, 2192, 1925, 2725, 11, 61, 6523, 2237, 1927, 12744, 1930, 2310, 3682, 1942, 3]}]}
{"query": {"id": "q_5039", "content": "topiramate [SEP]  nuclear factor kappa B and oxidative stress, and prevention by topiramate.", "tokenized_content": [2, 3700, 11979, 23874, 3, 4254, 2991, 12093, 44, 1930, 5163, 3071, 16, 1930, 5455, 2007, 3700, 11979, 23874, 18, 3]}, "items": [{"id": "p_5039", "content": "topiramate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3700, 11979, 23874, 3, 3]}]}
{"query": {"id": "q_5040", "content": "cocaine [SEP] Different mechanisms have been suggested for cocaine toxicity including an increase in oxidative stress but the asso", "tokenized_content": [2, 9045, 3, 2413, 3531, 2162, 2252, 3978, 1958, 9045, 5532, 2710, 1925, 2760, 1922, 5163, 3071, 2308, 1920, 2088, 1037, 3]}, "items": [{"id": "p_5040", "content": "Cocaine [SEP] An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinic", "score": 1, "type": null, "tokenized_content": [2, 9045, 3, 1925, 29951, 9603, 5210, 2037, 1920, 7484, 1927, 4793, 2710, 6880, 1019, 18, 2176, 1977, 43, 3076, 16111, 1930, 28404, 2684, 1930, 1977, 6248, 3]}]}
{"query": {"id": "q_5041", "content": "toxicity [SEP] Different mechanisms have been suggested for cocaine toxicity including an increase in oxidative stress but the association b", "tokenized_content": [2, 5532, 3, 2413, 3531, 2162, 2252, 3978, 1958, 9045, 5532, 2710, 1925, 2760, 1922, 5163, 3071, 2308, 1920, 3279, 44, 3]}, "items": [{"id": "p_5041", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_5042", "content": "nitric oxide [SEP] anisms. Therefore NFkappaB activity, oxidative stress, neuronal nitric oxide synthase (nNOS) activity, spatial learning and memory as well a", "tokenized_content": [2, 10233, 7491, 3, 11453, 2800, 18, 2955, 4651, 7640, 9434, 1993, 2455, 16, 5163, 3071, 16, 5121, 10233, 7491, 8921, 12, 22115, 13, 2455, 16, 5067, 4809, 1930, 4525, 1966, 3]}, "items": [{"id": "p_5042", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_5043", "content": "topiramate [SEP]  activity, spatial learning and memory as well as the effect of topiramate, a previously proposed therapy for cocaine addiction, were eval", "tokenized_content": [2, 3700, 11979, 23874, 3, 2455, 16, 5067, 4809, 1930, 4525, 1966, 2486, 1966, 1920, 2495, 1927, 3700, 11979, 23874, 16, 43, 3024, 4211, 3181, 1958, 9045, 12067, 16, 1985, 2180, 3]}, "items": [{"id": "p_5043", "content": "topiramate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3700, 11979, 23874, 3, 3]}]}
{"query": {"id": "q_5044", "content": "cocaine addiction [SEP]  as the effect of topiramate, a previously proposed therapy for cocaine addiction, were evaluated in an experimental model of cocaine administrat", "tokenized_content": [2, 9045, 12067, 3, 1966, 1920, 2495, 1927, 3700, 11979, 23874, 16, 43, 3024, 4211, 3181, 1958, 9045, 12067, 16, 1985, 3747, 1922, 1925, 3599, 2322, 1927, 9045, 10473, 1926, 3]}, "items": [{"id": "p_5044", "content": "Cocaine-Related Disorders [SEP] Disorders related or resulting from use of cocaine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9045, 17, 2712, 4414, 3, 4414, 2712, 2014, 3864, 2037, 2485, 1927, 9045, 18, 3]}]}
{"query": {"id": "q_5045", "content": "GSH [SEP] eased in the frontal cortex of cocaine treated rats, as well as GSH concentration and glutathione peroxidase activity in the hippoc", "tokenized_content": [2, 9973, 3, 13832, 1007, 1922, 1920, 8086, 4997, 1927, 9045, 2868, 3615, 16, 1966, 2486, 1966, 9973, 3110, 1930, 9153, 9433, 2455, 1922, 1920, 25771, 1030, 3]}, "items": [{"id": "p_5045", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_5046", "content": "glutathione [SEP] ortex of cocaine treated rats, as well as GSH concentration and glutathione peroxidase activity in the hippocampus, whereas nNOS activity i", "tokenized_content": [2, 9153, 3, 2014, 4583, 1927, 9045, 2868, 3615, 16, 1966, 2486, 1966, 9973, 3110, 1930, 9153, 9433, 2455, 1922, 1920, 7661, 16, 3417, 22115, 2455, 51, 3]}, "items": [{"id": "p_5046", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_5047", "content": "Topiramate [SEP] tive stress and NFkappaB in the alterations induced by cocaine. Topiramate prevented all the alterations observed, showing novel neuroprot", "tokenized_content": [2, 3700, 11979, 23874, 3, 8685, 1961, 3071, 1930, 4651, 7640, 9434, 1993, 1922, 1920, 5996, 2719, 2007, 9045, 18, 3700, 11979, 23874, 8715, 2136, 1920, 5996, 2528, 16, 4570, 4008, 3]}, "items": [{"id": "p_5047", "content": "topiramate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3700, 11979, 23874, 3, 3]}]}
{"query": {"id": "q_5048", "content": "PG-9 [SEP] antiamnesic properties of the presynaptic cholinergic amplifier PG-9.", "tokenized_content": [2, 5306, 17, 29, 3, 2246, 17652, 18522, 1030, 3879, 1927, 1920, 13111, 13908, 21289, 5306, 17, 29, 18, 3]}, "items": [{"id": "p_5048", "content": "N-methyltropan-3-yl 2-(4-bromophenyl)propionate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 1997, 8228, 1022, 17, 23, 17, 12111, 22, 17, 12, 24, 17, 21392, 17616, 2199, 13, 24682, 3, 3]}]}
{"query": {"id": "q_5049", "content": "3 alpha-tropyl 2-(p-bromophenyl)propionate [SEP] The antinociceptive effect of 3 alpha-tropyl 2-(p-bromophenyl)propionate [(+/-)-PG-9] (10-40 mg kg-1 s.c.; 30-60 mg kg-1 p.o.; 10-30 mg ", "tokenized_content": [2, 23, 4595, 17, 8465, 2199, 22, 17, 12, 58, 17, 21392, 17616, 2199, 13, 24682, 3, 1920, 29927, 2495, 1927, 23, 4595, 17, 8465, 2199, 22, 17, 12, 58, 17, 3]}, "items": [{"id": "p_5049", "content": "N-methyltropan-3-yl 2-(4-bromophenyl)propionate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 1997, 8228, 1022, 17, 23, 17, 12111, 22, 17, 12, 24, 17, 21392, 17616, 2199, 13, 24682, 3, 3]}]}
{"query": {"id": "q_5050", "content": "PG-9 [SEP] ive effect of 3 alpha-tropyl 2-(p-bromophenyl)propionate [(+/-)-PG-9] (10-40 mg kg-1 s.c.; 30-60 mg kg-1 p.o.; 10-30 mg kg-1 i.v.; 1", "tokenized_content": [2, 5306, 17, 29, 3, 4370, 1021, 2495, 1927, 23, 4595, 17, 8465, 2199, 22, 17, 12, 58, 17, 21392, 17616, 2199, 13, 24682, 37, 12, 15, 19, 17, 13, 17, 3]}, "items": [{"id": "p_5050", "content": "N-methyltropan-3-yl 2-(4-bromophenyl)propionate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 1997, 8228, 1022, 17, 23, 17, 12111, 22, 17, 12, 24, 17, 21392, 17616, 2199, 13, 24682, 3, 3]}]}
{"query": {"id": "q_5051", "content": "atropine [SEP] /-)-PG-9 was prevented by the unselective muscarinic antagonist atropine, the M1-selective antagonists pirenzepine and dicyclomine and t", "tokenized_content": [2, 24031, 3, 19, 17, 13, 17, 5306, 17, 29, 1982, 8715, 2007, 1920, 6398, 25568, 20318, 8151, 24031, 16, 1920, 8510, 17, 5328, 10515, 13774, 4389, 2128, 2053, 1930, 9192, 3]}, "items": [{"id": "p_5051", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_5052", "content": "pirenzepine [SEP] ve muscarinic antagonist atropine, the M1-selective antagonists pirenzepine and dicyclomine and the acetylcholine depletor hemicholinium-3,", "tokenized_content": [2, 13774, 4389, 2128, 2053, 3, 3428, 20318, 8151, 24031, 16, 1920, 8510, 17, 5328, 10515, 13774, 4389, 2128, 2053, 1930, 9192, 3143, 1947, 2053, 1930, 1920, 14561, 8863, 1924, 25482, 3]}, "items": [{"id": "p_5052", "content": "Pirenzepine [SEP] An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, sa", "score": 1, "type": null, "tokenized_content": [2, 13774, 4389, 2128, 2053, 3, 1925, 20330, 7801, 18979, 5899, 1988, 7042, 6319, 5512, 2019, 2826, 5312, 2254, 2032, 3414, 1942, 4081, 8375, 9254, 16, 4611, 3]}]}
{"query": {"id": "q_5053", "content": "dicyclomine [SEP] tagonist atropine, the M1-selective antagonists pirenzepine and dicyclomine and the acetylcholine depletor hemicholinium-3, but not by the ", "tokenized_content": [2, 9192, 3143, 1947, 2053, 3, 5218, 13339, 2156, 24031, 16, 1920, 8510, 17, 5328, 10515, 13774, 4389, 2128, 2053, 1930, 9192, 3143, 1947, 2053, 1930, 1920, 14561, 8863, 1924, 25482, 3]}, "items": [{"id": "p_5053", "content": "Dicyclomine [SEP] A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the", "score": 1, "type": null, "tokenized_content": [2, 9192, 3143, 1947, 2053, 3, 43, 20318, 8151, 2251, 1966, 1925, 8059, 4302, 18538, 12486, 1930, 1922, 7075, 16783, 18, 2176, 2258, 5082, 2495, 1990, 21808, 5512, 2014, 1920, 3]}]}
{"query": {"id": "q_5054", "content": "acetylcholine [SEP] he M1-selective antagonists pirenzepine and dicyclomine and the acetylcholine depletor hemicholinium-3, but not by the opioid antagonist nalo", "tokenized_content": [2, 14561, 3, 2234, 8510, 17, 5328, 10515, 13774, 4389, 2128, 2053, 1930, 9192, 3143, 1947, 2053, 1930, 1920, 14561, 8863, 1924, 25482, 12074, 11566, 1989, 17, 23, 16, 2308, 2084, 3]}, "items": [{"id": "p_5054", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_5055", "content": "hemicholinium-3 [SEP] ists pirenzepine and dicyclomine and the acetylcholine depletor hemicholinium-3, but not by the opioid antagonist naloxone, the gamma-aminobuty", "tokenized_content": [2, 25482, 12074, 11566, 1989, 17, 23, 3, 1977, 1973, 13774, 4389, 2128, 2053, 1930, 9192, 3143, 1947, 2053, 1930, 1920, 14561, 8863, 1924, 25482, 12074, 11566, 1989, 17, 23, 16, 3]}, "items": [{"id": "p_5055", "content": "Hemicholinium 3 [SEP] A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since c", "score": 1, "type": null, "tokenized_content": [2, 25482, 12074, 11566, 1989, 23, 3, 43, 6828, 4106, 1927, 1920, 2149, 5173, 5047, 2433, 1958, 15440, 18, 2176, 2258, 2941, 2495, 1990, 1920, 2330, 5173, 5047, 2433, 18, 3328, 45, 3]}]}
{"query": {"id": "q_5056", "content": "naloxone [SEP] line depletor hemicholinium-3, but not by the opioid antagonist naloxone, the gamma-aminobutyric acidB antagonist 3-aminopropyl-diethoxy", "tokenized_content": [2, 21926, 3, 2823, 8863, 1924, 25482, 12074, 11566, 1989, 17, 23, 16, 2308, 2084, 2007, 1920, 9384, 8151, 21926, 16, 1920, 7034, 17, 29093, 2687, 1014, 8151, 23, 17, 3835, 3]}, "items": [{"id": "p_5056", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_5057", "content": "gamma-aminobutyric acidB [SEP] hemicholinium-3, but not by the opioid antagonist naloxone, the gamma-aminobutyric acidB antagonist 3-aminopropyl-diethoxy-methyl-phosphinic acid, the H", "tokenized_content": [2, 7034, 17, 29093, 2687, 1014, 3, 25482, 12074, 11566, 1989, 17, 23, 16, 2308, 2084, 2007, 1920, 9384, 8151, 21926, 16, 1920, 7034, 17, 29093, 2687, 1014, 8151, 23, 17, 3]}, "items": [{"id": "p_5057", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_5058", "content": "3-aminopropyl-diethoxy-methyl-phosphinic acid [SEP] id antagonist naloxone, the gamma-aminobutyric acidB antagonist 3-aminopropyl-diethoxy-methyl-phosphinic acid, the H3 agonist R-(alpha)-methylhistamine, the D2 antagonist qu", "tokenized_content": [2, 23, 17, 3835, 20194, 2199, 17, 3986, 10647, 10465, 17, 4963, 17, 2766, 26386, 2687, 3, 2313, 8151, 21926, 16, 1920, 7034, 17, 29093, 2687, 1014, 8151, 23, 17, 3835, 3]}, "items": [{"id": "p_5058", "content": "CGP 35348 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7294, 1034, 26450, 6301, 3, 3]}]}
{"query": {"id": "q_5059", "content": "R-(alpha)-methylhistamine [SEP] t 3-aminopropyl-diethoxy-methyl-phosphinic acid, the H3 agonist R-(alpha)-methylhistamine, the D2 antagonist quinpirole, the 5-hydroxytryptamine4 antagon", "tokenized_content": [2, 60, 17, 12, 4595, 13, 17, 4963, 17210, 3857, 25157, 3, 62, 23, 17, 3835, 20194, 2199, 17, 3986, 10647, 10465, 17, 4963, 17, 2766, 26386, 2687, 16, 1920, 8170, 3]}, "items": [{"id": "p_5059", "content": "alpha-methylhistamine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 4963, 17210, 3857, 25157, 3, 3]}]}
{"query": {"id": "q_5060", "content": "quinpirole [SEP] id, the H3 agonist R-(alpha)-methylhistamine, the D2 antagonist quinpirole, the 5-hydroxytryptamine4 antagonist 2-methoxy-4-amino-5-chloro", "tokenized_content": [2, 9012, 10984, 15828, 3, 2313, 16, 1920, 8170, 7829, 60, 17, 12, 4595, 13, 17, 4963, 17210, 3857, 25157, 16, 1920, 8631, 8151, 9012, 10984, 15828, 16, 1920, 25, 17, 3]}, "items": [{"id": "p_5060", "content": "Quinpirole [SEP] A dopamine D2/D3 receptor agonist.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9012, 10984, 15828, 3, 43, 7964, 8631, 19, 11319, 3148, 7829, 18, 3]}]}
{"query": {"id": "q_5061", "content": "5-hydroxytryptamine4 [SEP] st R-(alpha)-methylhistamine, the D2 antagonist quinpirole, the 5-hydroxytryptamine4 antagonist 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylami", "tokenized_content": [2, 25, 17, 8275, 30298, 3812, 1006, 3, 1955, 60, 17, 12, 4595, 13, 17, 4963, 17210, 3857, 25157, 16, 1920, 8631, 8151, 9012, 10984, 15828, 16, 1920, 25, 17, 8275, 3]}, "items": [{"id": "p_5061", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_5062", "content": "2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester [SEP] e D2 antagonist quinpirole, the 5-hydroxytryptamine4 antagonist 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester hydrochloride, the 5-hydroxytryptamin1A antagonist 1-(2-methoxy", "tokenized_content": [2, 22, 17, 17954, 17, 24, 17, 3835, 17, 25, 17, 10107, 13058, 8643, 2687, 22, 17, 12, 18622, 19143, 13, 7843, 9603, 3, 47, 8631, 8151, 9012, 10984, 15828, 16, 3]}, "items": [{"id": "p_5062", "content": "2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 22, 17, 17954, 17, 24, 17, 3835, 17, 25, 17, 10107, 13058, 8643, 2687, 22, 17, 12, 18622, 19143, 13, 7843, 9603, 3, 3]}]}
{"query": {"id": "q_5063", "content": "5-hydroxytryptamin1A [SEP] lorobenzoic acid 2-(diethylamino)ethyl ester hydrochloride, the 5-hydroxytryptamin1A antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]pipera", "tokenized_content": [2, 25, 17, 8275, 30298, 3717, 6146, 3, 16394, 14601, 8643, 2687, 22, 17, 12, 18622, 19143, 13, 7843, 9603, 16675, 16, 1920, 25, 17, 8275, 30298, 3717, 6146, 8151, 21, 3]}, "items": [{"id": "p_5063", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_5064", "content": "1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine [SEP] )ethyl ester hydrochloride, the 5-hydroxytryptamin1A antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide and the polyamines depletor reserpine. Based on th", "tokenized_content": [2, 21, 17, 12, 22, 17, 17954, 17616, 2199, 13, 17, 24, 17, 37, 24, 17, 12, 22, 17, 19686, 26060, 1037, 13, 16936, 39, 16057, 10119, 3, 13, 7843, 9603, 3]}, "items": [{"id": "p_5064", "content": "1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 12, 22, 17, 17954, 17616, 2199, 13, 17, 24, 17, 12, 24, 17, 12, 22, 17, 19686, 26060, 1037, 13, 16936, 13, 16057, 10119, 3, 3]}]}
{"query": {"id": "q_5065", "content": "reserpine [SEP] imido)butyl]piperazine hydrobromide and the polyamines depletor reserpine. Based on these data, it can be postulated that (+/-)-PG-9 exer", "tokenized_content": [2, 1995, 1915, 12184, 3, 20697, 1037, 13, 16936, 39, 16057, 10119, 3290, 18474, 16408, 1021, 1930, 1920, 27883, 1036, 8863, 1924, 1995, 1915, 12184, 18, 2454, 1990, 2144, 2230, 16, 3]}, "items": [{"id": "p_5065", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_5066", "content": "amnesia [SEP] ansmission. (+/-)-PG-9 (10-40 mg kg-1 i.p.) was able to prevent amnesia induced by scopolamine (1 mg kg-1 i.p.) and dicyclomine (2 mg k", "tokenized_content": [2, 14701, 7156, 3, 18229, 13211, 18, 12, 15, 19, 17, 13, 17, 5306, 17, 29, 12, 2119, 17, 3040, 2786, 3621, 17, 21, 51, 18, 58, 18, 13, 1982, 4236, 3]}, "items": [{"id": "p_5066", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_5067", "content": "scopolamine [SEP] G-9 (10-40 mg kg-1 i.p.) was able to prevent amnesia induced by scopolamine (1 mg kg-1 i.p.) and dicyclomine (2 mg kg-1 i.p.) in the mouse ", "tokenized_content": [2, 25392, 10173, 25157, 3, 49, 17, 29, 12, 2119, 17, 3040, 2786, 3621, 17, 21, 51, 18, 58, 18, 13, 1982, 4236, 1942, 4625, 14701, 7156, 2719, 2007, 25392, 10173, 3]}, "items": [{"id": "p_5067", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_5068", "content": "amnesic [SEP]  that might be responsible for the antinociception and the anti-amnesic effect induced by (+/-)-PG-9 through an increase in acetylcholi", "tokenized_content": [2, 14701, 18522, 1030, 3, 1988, 3284, 1998, 5061, 1958, 1920, 23960, 15577, 1930, 1920, 2246, 17, 14701, 18522, 1030, 2495, 2719, 2007, 12, 15, 19, 17, 13, 17, 5306, 17, 3]}, "items": [{"id": "p_5068", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_5069", "content": "oxygen [SEP] Hyperbaric oxygen therapy for control of intractable cyclophosphamide-induced hem", "tokenized_content": [2, 4612, 3, 4194, 8751, 1935, 4612, 3181, 1958, 2285, 1927, 26032, 17135, 17, 2719, 3243, 3]}, "items": [{"id": "p_5069", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_5070", "content": "cyclophosphamide [SEP] Hyperbaric oxygen therapy for control of intractable cyclophosphamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 17135, 3, 4194, 8751, 1935, 4612, 3181, 1958, 2285, 1927, 26032, 17135, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_5070", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_5071", "content": "hemorrhagic [SEP] gen therapy for control of intractable cyclophosphamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 16052, 3, 2065, 3181, 1958, 2285, 1927, 26032, 17135, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_5071", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_5072", "content": "cystitis [SEP] for control of intractable cyclophosphamide-induced hemorrhagic cystitis.", "tokenized_content": [2, 9446, 3678, 3, 1958, 2285, 1927, 26032, 17135, 17, 2719, 16052, 9446, 3678, 18, 3]}, "items": [{"id": "p_5072", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_5073", "content": "hemorrhagic [SEP] We report a case of intractable hemorrhagic cystitis due to cyclophosphamide therapy for Wegener's granulom", "tokenized_content": [2, 16052, 3, 2038, 3809, 43, 3087, 1927, 26032, 16052, 9446, 3678, 2810, 1942, 17135, 3181, 1958, 2038, 14687, 1005, 11, 61, 9015, 1947, 3]}, "items": [{"id": "p_5073", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_5074", "content": "cystitis [SEP] We report a case of intractable hemorrhagic cystitis due to cyclophosphamide therapy for Wegener's granulomatosis. C", "tokenized_content": [2, 9446, 3678, 3, 2038, 3809, 43, 3087, 1927, 26032, 16052, 9446, 3678, 2810, 1942, 17135, 3181, 1958, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 18, 45, 3]}, "items": [{"id": "p_5074", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_5075", "content": "cyclophosphamide [SEP] We report a case of intractable hemorrhagic cystitis due to cyclophosphamide therapy for Wegener's granulomatosis. Conservative treatment, i", "tokenized_content": [2, 17135, 3, 2038, 3809, 43, 3087, 1927, 26032, 16052, 9446, 3678, 2810, 1942, 17135, 3181, 1958, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 18, 11375, 2311, 16, 51, 3]}, "items": [{"id": "p_5075", "content": "Cyclophosphamide [SEP] Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to fo", "score": 1, "type": null, "tokenized_content": [2, 17135, 3, 7897, 1927, 1925, 28912, 6634, 4902, 2211, 29128, 9969, 1930, 12910, 5899, 1988, 4902, 1998, 4128, 1922, 1920, 3568, 1942, 5917, 3]}]}
{"query": {"id": "q_5076", "content": "Wegener's granulomatosis [SEP] ctable hemorrhagic cystitis due to cyclophosphamide therapy for Wegener's granulomatosis. Conservative treatment, including bladder irrigation with phys", "tokenized_content": [2, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 3, 19038, 7272, 16052, 9446, 3678, 2810, 1942, 17135, 3181, 1958, 2038, 14687, 1005, 11, 61, 25675, 4575, 8362, 18, 11375, 2311, 3]}, "items": [{"id": "p_5076", "content": "Granulomatosis with Polyangiitis [SEP] A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) l", "score": 1, "type": null, "tokenized_content": [2, 25675, 4575, 8362, 1956, 4286, 9506, 3678, 3, 43, 13564, 2405, 1935, 2573, 1927, 43, 2796, 3299, 3872, 18, 2176, 1977, 4378, 2007, 4531, 1927, 1920, 2877, 7208, 12, 21548, 13, 54, 3]}]}
{"query": {"id": "q_5077", "content": "prostaglandin F2 alpha [SEP] ladder irrigation with physiological saline and instillation of prostaglandin F2 alpha, failed to totally control hemorrhage. We then used hyperbaric ", "tokenized_content": [2, 15900, 11063, 4595, 3, 22798, 18224, 1956, 5005, 5977, 1930, 24893, 1927, 15900, 11063, 4595, 16, 6617, 1942, 15616, 2285, 10489, 18, 2038, 2759, 2251, 4194, 8751, 1935, 3]}, "items": [{"id": "p_5077", "content": "Dinoprost [SEP] A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile prop", "score": 1, "type": null, "tokenized_content": [2, 11687, 21898, 3, 43, 10414, 6966, 15900, 1988, 2258, 16462, 19977, 16, 12867, 6586, 16, 1930, 11380, 3058, 28278, 1939, 4209, 18, 2810, 1942, 2496, 22866, 12334, 10261, 2341, 2383, 5062, 3]}]}
{"query": {"id": "q_5078", "content": "hemorrhage [SEP] stillation of prostaglandin F2 alpha, failed to totally control hemorrhage. We then used hyperbaric oxygen at an absolute pressure of 2 at", "tokenized_content": [2, 10489, 3, 3974, 1943, 1927, 15900, 11063, 4595, 16, 6617, 1942, 15616, 2285, 10489, 18, 2038, 2759, 2251, 4194, 8751, 1935, 4612, 2019, 1925, 6961, 3772, 1927, 22, 2019, 3]}, "items": [{"id": "p_5078", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_5079", "content": "oxygen [SEP] , failed to totally control hemorrhage. We then used hyperbaric oxygen at an absolute pressure of 2 atm, 5 days a week for 8 consecuti", "tokenized_content": [2, 4612, 3, 16, 6617, 1942, 15616, 2285, 10489, 18, 2038, 2759, 2251, 4194, 8751, 1935, 4612, 2019, 1925, 6961, 3772, 1927, 22, 7513, 16, 25, 3000, 43, 2982, 1958, 28, 3]}, "items": [{"id": "p_5079", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_5080", "content": "bleeding [SEP] e pressure of 2 atm, 5 days a week for 8 consecutive weeks. The bleeding ceased completely by the end of treatment and the patient remai", "tokenized_content": [2, 7633, 3, 47, 3772, 1927, 22, 7513, 16, 25, 3000, 43, 2982, 1958, 28, 7351, 3625, 18, 1920, 7633, 14292, 4127, 1007, 5796, 2007, 1920, 2482, 1927, 2311, 1930, 1920, 3]}, "items": [{"id": "p_5080", "content": "Hemorrhage [SEP] Bleeding or escape of blood from a vessel.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10489, 3, 7633, 2014, 11781, 1927, 2877, 2037, 43, 8072, 18, 3]}]}
{"query": {"id": "q_5081", "content": "hematuria [SEP] letely by the end of treatment and the patient remained free of hematuria thereafter. No side effect was noted during the course of thera", "tokenized_content": [2, 30267, 3, 6307, 2264, 2007, 1920, 2482, 1927, 2311, 1930, 1920, 2774, 5410, 3294, 1927, 30267, 11598, 18, 2239, 4159, 2495, 1982, 5040, 2409, 1920, 4914, 1927, 2704, 1019, 3]}, "items": [{"id": "p_5081", "content": "Hematuria [SEP] Presence of blood in the urine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 30267, 3, 2990, 1927, 2877, 1922, 1920, 6960, 18, 3]}]}
{"query": {"id": "q_5082", "content": "p-choloroaniline [SEP] e reported. The results have shown that the degradation product p-choloroaniline is not a significant factor in chlorhexidine-digluconate associ", "tokenized_content": [2, 58, 17, 6268, 30232, 16692, 2053, 3, 47, 2568, 18, 1920, 2274, 2162, 2522, 1988, 1920, 4877, 4863, 58, 17, 6268, 30232, 16692, 2053, 1977, 2084, 43, 2228, 2991, 1922, 3]}, "items": [{"id": "p_5082", "content": "4-chloroaniline [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 24, 17, 10107, 16692, 2053, 3, 3]}]}
{"query": {"id": "q_5083", "content": "chlorhexidine-digluconate [SEP] adation product p-choloroaniline is not a significant factor in chlorhexidine-digluconate associated erosive cystitis. A high percentage of kanamycin-col", "tokenized_content": [2, 4891, 17797, 5802, 17, 4325, 18369, 8870, 3, 20357, 1929, 4863, 58, 17, 6268, 30232, 16692, 2053, 1977, 2084, 43, 2228, 2991, 1922, 4891, 17797, 5802, 17, 4325, 18369, 8870, 3]}, "items": [{"id": "p_5083", "content": "chlorhexidine gluconate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4891, 17797, 5802, 3351, 8870, 3, 3]}]}
{"query": {"id": "q_5084", "content": "cystitis [SEP] nificant factor in chlorhexidine-digluconate associated erosive cystitis. A high percentage of kanamycin-colistin and povidone-iodine ir", "tokenized_content": [2, 9446, 3678, 3, 17719, 13611, 1031, 2991, 1922, 4891, 17797, 5802, 17, 4325, 18369, 8870, 2458, 23898, 2320, 9446, 3678, 18, 43, 2149, 4466, 1927, 19404, 17, 27226, 1930, 2510, 3]}, "items": [{"id": "p_5084", "content": "Cystitis [SEP] Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful ", "score": 1, "type": null, "tokenized_content": [2, 9446, 3678, 3, 4531, 1927, 1920, 7075, 7821, 16, 3108, 2037, 4543, 2014, 2447, 17, 4543, 5092, 18, 9446, 3678, 1977, 5394, 2458, 1956, 15806, 3]}]}
{"query": {"id": "q_5085", "content": "kanamycin [SEP] e-digluconate associated erosive cystitis. A high percentage of kanamycin-colistin and povidone-iodine irrigations were associated with e", "tokenized_content": [2, 19404, 3, 47, 17, 4325, 18369, 8870, 2458, 23898, 2320, 9446, 3678, 18, 43, 2149, 4466, 1927, 19404, 17, 27226, 1930, 2510, 2165, 28615, 1021, 17, 14836, 18224, 1036, 1985, 3]}, "items": [{"id": "p_5085", "content": "Kanamycin [SEP] Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major com", "score": 1, "type": null, "tokenized_content": [2, 19404, 3, 7267, 2796, 4152, 2007, 22874, 12916, 26984, 1972, 2002, 1957, 2037, 10405, 6072, 18, 12936, 23, 4178, 30, 19404, 43, 16, 1920, 3044, 2008, 3]}]}
{"query": {"id": "q_5086", "content": "colistin [SEP] ate associated erosive cystitis. A high percentage of kanamycin-colistin and povidone-iodine irrigations were associated with erosive cy", "tokenized_content": [2, 27226, 3, 30280, 2458, 23898, 2320, 9446, 3678, 18, 43, 2149, 4466, 1927, 19404, 17, 27226, 1930, 2510, 2165, 28615, 1021, 17, 14836, 18224, 1036, 1985, 2458, 1956, 23898, 2320, 3]}, "items": [{"id": "p_5086", "content": "Colistin [SEP] Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which ", "score": 1, "type": null, "tokenized_content": [2, 27226, 3, 9821, 13022, 7267, 2037, 14587, 27226, 1957, 18, 2176, 1977, 7179, 1927, 3491, 28330, 1036, 11123, 1930, 6602, 12, 2014, 27226, 1036, 43, 16, 44, 16, 1930, 45, 13, 2154, 3]}]}
{"query": {"id": "q_5087", "content": "povidone-iodine [SEP] d erosive cystitis. A high percentage of kanamycin-colistin and povidone-iodine irrigations were associated with erosive cystitis and suggested", "tokenized_content": [2, 2510, 2165, 28615, 1021, 17, 14836, 3, 46, 23898, 2320, 9446, 3678, 18, 43, 2149, 4466, 1927, 19404, 17, 27226, 1930, 2510, 2165, 28615, 1021, 17, 14836, 18224, 1036, 1985, 3]}, "items": [{"id": "p_5087", "content": "Povidone-Iodine [SEP] An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aeroso", "score": 1, "type": null, "tokenized_content": [2, 2510, 2165, 28615, 1021, 17, 14836, 3, 1925, 8594, 4597, 18781, 4593, 2251, 1966, 12259, 8059, 17920, 1922, 3782, 1930, 1958, 4407, 1930, 27103, 3260, 5024, 16, 2222, 1966, 14629, 1037, 3]}]}
{"query": {"id": "q_5088", "content": "Picloxydine [SEP] ystitis and suggested a possible complication with human usage. Picloxydine irrigations appeared to have a lower incidence of erosive cysti", "tokenized_content": [2, 7271, 6012, 10465, 27099, 3, 24018, 11648, 1930, 3978, 43, 3216, 9388, 1956, 2616, 10070, 18, 7271, 6012, 10465, 27099, 18224, 1036, 6209, 1942, 2162, 43, 2826, 4332, 1927, 23898, 3]}, "items": [{"id": "p_5088", "content": "picloxydine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7271, 6012, 10465, 27099, 3, 3]}]}
{"query": {"id": "q_5089", "content": "bromperidol [SEP] A total of sixty patients were trated with bromperidol first in open conditions (20 patients), then on a double blind ", "tokenized_content": [2, 8808, 2116, 18630, 3, 43, 2698, 1927, 14063, 2132, 1985, 3390, 2013, 1956, 8808, 2116, 18630, 2561, 1922, 4437, 2961, 12, 2036, 2132, 13, 16, 2759, 1990, 43, 4825, 7109, 3]}, "items": [{"id": "p_5089", "content": "bromperidol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 8808, 2116, 18630, 3, 3]}]}
{"query": {"id": "q_5090", "content": "haloperidol [SEP]  (20 patients), then on a double blind basis (40 patients) with haloperidol as the reference substance. The open study lasted for four week", "tokenized_content": [2, 25107, 3, 12, 2036, 2132, 13, 16, 2759, 1990, 43, 4825, 7109, 4859, 12, 3040, 2132, 13, 1956, 25107, 1966, 1920, 4386, 7311, 18, 1920, 4437, 2161, 16276, 1958, 3006, 3]}, "items": [{"id": "p_5090", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5091", "content": "extrapyramidal concomitant symptoms [SEP]  statistical analysis. Nine patients exhibited mild to moderate extrapyramidal concomitant symptoms; no other side effects were observed. The results of detailed l", "tokenized_content": [2, 21346, 3553, 25238, 1923, 8537, 3601, 3, 3850, 2333, 18, 6360, 2132, 5065, 5809, 1942, 5086, 21346, 3553, 25238, 1923, 8537, 3601, 31, 2239, 2303, 4159, 2564, 1985, 2528, 18, 3]}, "items": [{"id": "p_5091", "content": "Basal Ganglia Diseases [SEP] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (mos", "score": 1, "type": null, "tokenized_content": [2, 5342, 13086, 3902, 3, 3902, 1927, 1920, 5342, 13086, 2710, 1920, 21332, 31, 4317, 1957, 12574, 10015, 1036, 31, 6958, 3894, 1989, 31, 10637, 31, 1930, 18955, 5607, 18, 3890, 26682, 1036, 12, 7500, 3]}]}
{"query": {"id": "q_5092", "content": "psychotic syndromes belonging predominantly to the schizophrenia group [SEP] ubstances were found to be highly effective in the treatment of psychotic syndromes belonging predominantly to the schizophrenia group. Certain clues, including the onset of action, seem to be indic", "tokenized_content": [2, 16651, 12688, 10588, 7700, 1942, 1920, 7899, 2210, 3, 4803, 2156, 3736, 1985, 2435, 1942, 1998, 3626, 3655, 1922, 1920, 2311, 1927, 16651, 12688, 10588, 7700, 1942, 1920, 7899, 2210, 3]}, "items": [{"id": "p_5092", "content": "Schizophrenia and Disorders with Psychotic Features [SEP] Marked disorders of thought (delusions, hallucinations, or other thought disorder accompanied by disordered affect or behavior),", "score": 1, "type": null, "tokenized_content": [2, 7899, 1930, 4414, 1956, 16651, 4075, 3, 4961, 4414, 1927, 6212, 12, 2723, 3910, 16, 27013, 16, 2014, 2303, 6212, 4770, 7936, 2007, 13885, 4081, 2014, 3379, 13, 16, 3]}]}
{"query": {"id": "q_5093", "content": "Curcumin [SEP] Curcumin ameliorates cognitive dysfunction and oxidative damage in pheno", "tokenized_content": [2, 12960, 3, 12960, 20611, 1036, 4328, 5273, 1930, 5163, 4293, 1922, 3037, 1037, 3]}, "items": [{"id": "p_5093", "content": "Curcumin [SEP] A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper an", "score": 1, "type": null, "tokenized_content": [2, 12960, 3, 43, 7463, 17, 10613, 8347, 2926, 2037, 2497, 3383, 16, 1920, 10201, 1919, 5904, 1927, 12350, 23813, 2815, 1019, 18, 2176, 1977, 2251, 1922, 1920, 6040, 1927, 12350, 23813, 4648, 1925, 3]}]}
{"query": {"id": "q_5094", "content": "cognitive dysfunction [SEP] Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine admini", "tokenized_content": [2, 4328, 5273, 3, 12960, 20611, 1036, 4328, 5273, 1930, 5163, 4293, 1922, 3037, 18854, 6827, 1930, 30315, 3318, 1033, 3]}, "items": [{"id": "p_5094", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_5095", "content": "phenobarbitone [SEP] cumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.", "tokenized_content": [2, 3037, 18854, 6827, 3, 7394, 1921, 20611, 1036, 4328, 5273, 1930, 5163, 4293, 1922, 3037, 18854, 6827, 1930, 30315, 5254, 3615, 18, 3]}, "items": [{"id": "p_5095", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_5096", "content": "carbamazepine [SEP] ognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.", "tokenized_content": [2, 30315, 3, 17395, 8635, 2185, 5273, 1930, 5163, 4293, 1922, 3037, 18854, 6827, 1930, 30315, 5254, 3615, 18, 3]}, "items": [{"id": "p_5096", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_5097", "content": "phenobarbitone [SEP] The antiepileptic drugs, phenobarbitone and carbamazepine are well known to cause cognitive impairment ", "tokenized_content": [2, 3037, 18854, 6827, 3, 1920, 29132, 4195, 16, 3037, 18854, 6827, 1930, 30315, 2032, 2486, 3171, 1942, 3936, 4328, 6159, 3]}, "items": [{"id": "p_5097", "content": "Phenobarbital [SEP] A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC AC", "score": 1, "type": null, "tokenized_content": [2, 3037, 18986, 3, 43, 30434, 4219, 3133, 2687, 10533, 1988, 8016, 1966, 43, 6771, 25568, 4101, 7580, 2433, 20852, 2031, 18, 2176, 29734, 7034, 17, 29093, 2000, 3]}]}
{"query": {"id": "q_5098", "content": "carbamazepine [SEP] The antiepileptic drugs, phenobarbitone and carbamazepine are well known to cause cognitive impairment on chronic use. Th", "tokenized_content": [2, 30315, 3, 1920, 29132, 4195, 16, 3037, 18854, 6827, 1930, 30315, 2032, 2486, 3171, 1942, 3936, 4328, 6159, 1990, 3724, 2485, 18, 1913, 3]}, "items": [{"id": "p_5098", "content": "Carbamazepine [SEP] An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but s", "score": 1, "type": null, "tokenized_content": [2, 30315, 3, 1925, 26572, 2031, 2251, 1942, 2285, 12038, 3054, 1930, 26261, 2014, 8083, 10060, 18, 2496, 5754, 1927, 4615, 1977, 2084, 5437, 7372, 16, 2308, 61, 3]}]}
{"query": {"id": "q_5099", "content": "cognitive impairment [SEP] drugs, phenobarbitone and carbamazepine are well known to cause cognitive impairment on chronic use. The increase in free radical generation has bee", "tokenized_content": [2, 4328, 6159, 3, 4195, 16, 3037, 18854, 6827, 1930, 30315, 2032, 2486, 3171, 1942, 3936, 4328, 6159, 1990, 3724, 2485, 18, 1920, 2760, 1922, 3294, 6917, 4841, 2258, 20006, 3]}, "items": [{"id": "p_5099", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_5100", "content": "Curcumin [SEP] tant mechanisms of cognitive impairment by antiepileptic drugs. Curcumin has shown antioxidant, anti-inflammatory and neuro-protective p", "tokenized_content": [2, 12960, 3, 10434, 1031, 3531, 1927, 4328, 6159, 2007, 29132, 4195, 18, 12960, 2258, 2522, 7335, 16, 2246, 17, 3769, 1930, 3366, 17, 6337, 58, 3]}, "items": [{"id": "p_5100", "content": "Curcumin [SEP] A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper an", "score": 1, "type": null, "tokenized_content": [2, 12960, 3, 43, 7463, 17, 10613, 8347, 2926, 2037, 2497, 3383, 16, 1920, 10201, 1919, 5904, 1927, 12350, 23813, 2815, 1019, 18, 2176, 1977, 2251, 1922, 1920, 6040, 1927, 12350, 23813, 4648, 1925, 3]}]}
{"query": {"id": "q_5101", "content": "curcumin [SEP] sent study was carried out to investigate the effect of chronic curcumin administration on phenobarbitone- and carbamazepine-induced cog", "tokenized_content": [2, 12960, 3, 8437, 2161, 1982, 4371, 2397, 1942, 4482, 1920, 2495, 1927, 3724, 12960, 4183, 1990, 3037, 18854, 6827, 17, 1930, 30315, 17, 2719, 17082, 3]}, "items": [{"id": "p_5101", "content": "Curcumin [SEP] A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper an", "score": 1, "type": null, "tokenized_content": [2, 12960, 3, 43, 7463, 17, 10613, 8347, 2926, 2037, 2497, 3383, 16, 1920, 10201, 1919, 5904, 1927, 12350, 23813, 2815, 1019, 18, 2176, 1977, 2251, 1922, 1920, 6040, 1927, 12350, 23813, 4648, 1925, 3]}]}
{"query": {"id": "q_5102", "content": "malondialdehyde [SEP] udy period, serum phenobarbitone and carbamazepine, whole brain malondialdehyde and reduced glutathione levels were estimated. The administrati", "tokenized_content": [2, 24270, 3, 19803, 1012, 3047, 16, 3256, 3037, 18854, 6827, 1930, 30315, 16, 4292, 3068, 24270, 1930, 3028, 9153, 2428, 1985, 4185, 18, 1920, 10473, 1968, 3]}, "items": [{"id": "p_5102", "content": "Malondialdehyde [SEP] The dialdehyde of malonic acid.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24270, 3, 1920, 7588, 6542, 1927, 3054, 3490, 2687, 18, 3]}]}
{"query": {"id": "q_5103", "content": "glutathione [SEP] tone and carbamazepine, whole brain malondialdehyde and reduced glutathione levels were estimated. The administration of phenobarbitone and", "tokenized_content": [2, 9153, 3, 11020, 1930, 30315, 16, 4292, 3068, 24270, 1930, 3028, 9153, 2428, 1985, 4185, 18, 1920, 4183, 1927, 3037, 18854, 6827, 1930, 3]}, "items": [{"id": "p_5103", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_5104", "content": "impairment of learning and memory [SEP] henobarbitone and carbamazepine for 21days caused a significant impairment of learning and memory as well as an increased oxidative stress. Concomitant curcumin ", "tokenized_content": [2, 6159, 1927, 4809, 1930, 4525, 3, 14618, 18854, 6827, 1930, 30315, 1958, 2900, 27533, 4189, 43, 2228, 6159, 1927, 4809, 1930, 4525, 1966, 2486, 1966, 1925, 2502, 5163, 3071, 18, 3]}, "items": [{"id": "p_5104", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_5105", "content": "deterioration of cognitive functions [SEP] ults show that curcumin has beneficial effect in mitigating the deterioration of cognitive functions and oxidative damage in rats treated with phenobarbitone and ca", "tokenized_content": [2, 13318, 1927, 4328, 4088, 3, 3570, 1973, 2146, 1988, 12960, 2258, 6928, 2495, 1922, 11833, 2287, 1920, 13318, 1927, 4328, 4088, 1930, 5163, 4293, 1922, 3615, 2868, 1956, 3037, 18854, 3]}, "items": [{"id": "p_5105", "content": "Cognition Disorders [SEP] Disturbances in the mental process related to thinking, reasoning, and judgment.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10032, 4414, 3, 12654, 1922, 1920, 5018, 2585, 2712, 1942, 14778, 16, 16301, 16, 1930, 17449, 18, 3]}]}
{"query": {"id": "q_5106", "content": "Pyrrolidine dithiocarbamate [SEP] Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepti", "tokenized_content": [2, 23878, 5802, 18061, 22780, 21084, 3, 23878, 5802, 18061, 22780, 21084, 14576, 1920, 13774, 6154, 4997, 1922, 1920, 7547, 7095, 12184, 3642, 28367, 1033, 3]}, "items": [{"id": "p_5106", "content": "pyrrolidine dithiocarbamic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23878, 5802, 18061, 22780, 13514, 2687, 3, 3]}]}
{"query": {"id": "q_5107", "content": "pilocarpine [SEP] Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model.", "tokenized_content": [2, 7547, 7095, 12184, 3, 23878, 5802, 18061, 22780, 21084, 14576, 1920, 13774, 6154, 4997, 1922, 1920, 7547, 7095, 12184, 3642, 16304, 1957, 2322, 18, 3]}, "items": [{"id": "p_5107", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_5108", "content": "status epilepticus [SEP] dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model.", "tokenized_content": [2, 3642, 16304, 1957, 3, 18061, 22780, 21084, 14576, 1920, 13774, 6154, 4997, 1922, 1920, 7547, 7095, 12184, 3642, 16304, 1957, 2322, 18, 3]}, "items": [{"id": "p_5108", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_5109", "content": "Pyrrolidine dithiocarbamate [SEP] Pyrrolidine dithiocarbamate (PDTC) has a dual mechanism of action as an antioxidant and an ", "tokenized_content": [2, 23878, 5802, 18061, 22780, 21084, 3, 23878, 5802, 18061, 22780, 21084, 12, 16417, 1030, 13, 2258, 43, 7064, 2856, 1927, 4615, 1966, 1925, 7335, 1930, 1925, 3]}, "items": [{"id": "p_5109", "content": "pyrrolidine dithiocarbamic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23878, 5802, 18061, 22780, 13514, 2687, 3, 3]}]}
{"query": {"id": "q_5110", "content": "PDTC [SEP] Pyrrolidine dithiocarbamate (PDTC) has a dual mechanism of action as an antioxidant and an inhibi", "tokenized_content": [2, 16417, 1030, 3, 23878, 5802, 18061, 22780, 21084, 12, 16417, 1030, 13, 2258, 43, 7064, 2856, 1927, 4615, 1966, 1925, 7335, 1930, 1925, 2439, 1033, 3]}, "items": [{"id": "p_5110", "content": "pyrrolidine dithiocarbamic acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 23878, 5802, 18061, 22780, 13514, 2687, 3, 3]}]}
{"query": {"id": "q_5111", "content": "oxygen [SEP] e transcription factor kappa-beta. Both, production of reactive oxygen species as well as activation of NF-kappaB have been implicated", "tokenized_content": [2, 4612, 3, 47, 3213, 2991, 12093, 17, 4666, 18, 2321, 16, 3372, 1927, 6079, 4612, 3038, 1966, 2486, 1966, 2936, 1927, 4651, 17, 19901, 2162, 2252, 6835, 3]}, "items": [{"id": "p_5111", "content": "Oxygen [SEP] An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on ear", "score": 1, "type": null, "tokenized_content": [2, 4612, 3, 1925, 6149, 1956, 11241, 17530, 57, 16, 11241, 2529, 28, 16, 1930, 11241, 3388, 37, 2461, 18, 23598, 12962, 31, 2461, 18, 23598, 7658, 39, 18, 2176, 1977, 1920, 2501, 7437, 6149, 1990, 4352, 3]}]}
{"query": {"id": "q_5112", "content": "neuronal damage [SEP]  well as activation of NF-kappaB have been implicated in severe neuronal damage in different sub-regions of the hippocampus as well as in the s", "tokenized_content": [2, 5121, 4293, 3, 2486, 1966, 2936, 1927, 4651, 17, 19901, 2162, 2252, 6835, 1922, 4010, 5121, 4293, 1922, 2413, 2316, 17, 3451, 1927, 1920, 7661, 1966, 2486, 1966, 1922, 1920, 3]}, "items": [{"id": "p_5112", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_5113", "content": "status epilepticus [SEP] s as well as in the surrounding cortices. The effect of PDTC on status epilepticus-associated cell loss in the hippocampus and piriform cortex was", "tokenized_content": [2, 3642, 16304, 1957, 3, 61, 1966, 2486, 1966, 1922, 1920, 7510, 18220, 18, 1920, 2495, 1927, 16417, 1030, 1990, 3642, 16304, 1957, 17, 2458, 2024, 3257, 1922, 1920, 7661, 1930, 3]}, "items": [{"id": "p_5113", "content": "Status Epilepticus [SEP] A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30", "score": 1, "type": null, "tokenized_content": [2, 3642, 16304, 1957, 3, 43, 7171, 11015, 2014, 10060, 5116, 5467, 7867, 1942, 4625, 5241, 2192, 9232, 6966, 2338, 43, 3047, 1927, 2036, 17, 2627, 3]}]}
{"query": {"id": "q_5114", "content": "pilocarpine [SEP] ampus and piriform cortex was evaluated in the rat fractionated pilocarpine model. Treatment with 150 mg/kg PDTC before and following statu", "tokenized_content": [2, 7547, 7095, 12184, 3, 3681, 1957, 1930, 13774, 6154, 4997, 1982, 3747, 1922, 1920, 3067, 18225, 7547, 7095, 12184, 2322, 18, 2311, 1956, 5493, 2786, 19, 3621, 16417, 1030, 3119, 3]}, "items": [{"id": "p_5114", "content": "Pilocarpine [SEP] A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glauco", "score": 1, "type": null, "tokenized_content": [2, 7547, 7095, 12184, 3, 43, 11240, 21665, 20318, 7829, 1956, 2239, 20239, 2564, 18, 7547, 7095, 12184, 1977, 2251, 1966, 43, 6519, 3153, 1930, 1922, 1920, 2311, 1927, 11113, 1037, 3]}]}
{"query": {"id": "q_5115", "content": "neuronal loss [SEP]  protected the piriform cortex, whereas it did not affect hilar neuronal loss. These data might indicate that the generation of reactive oxyg", "tokenized_content": [2, 5121, 3257, 3, 9713, 1920, 13774, 6154, 4997, 16, 3417, 2176, 2811, 2084, 4081, 18077, 1933, 5121, 3257, 18, 2144, 2230, 3284, 3579, 1988, 1920, 4841, 1927, 6079, 20004, 1029, 3]}, "items": [{"id": "p_5115", "content": "Nerve Degeneration [SEP] Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction o", "score": 1, "type": null, "tokenized_content": [2, 5507, 9174, 3, 3257, 1927, 3183, 2455, 1930, 19030, 9174, 1927, 5507, 9725, 1930, 2310, 4262, 19590, 7180, 2894, 1920, 12102, 57, 3]}]}
{"query": {"id": "q_5116", "content": "seizure [SEP] pecies and activation of NF-kappaB plays a more central role in seizure-associated neuronal damage in the temporal cortex as compared t", "tokenized_content": [2, 11015, 3, 13494, 2062, 1930, 2936, 1927, 4651, 17, 19901, 5705, 43, 2253, 4101, 2770, 1922, 11015, 17, 2458, 5121, 4293, 1922, 1920, 5338, 4997, 1966, 2452, 62, 3]}, "items": [{"id": "p_5116", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5117", "content": "nicotine [SEP] Safety profile of a nicotine lozenge compared with that of nicotine gum in adult smokers wit", "tokenized_content": [2, 9303, 3, 5407, 5174, 1927, 43, 9303, 3004, 7490, 2106, 2452, 1956, 1988, 1927, 9303, 20654, 1922, 4160, 8112, 16086, 3]}, "items": [{"id": "p_5117", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_5118", "content": "Nicotine [SEP] BACKGROUND: Nicotine polacrilex lozenges deliver 25% to 27% more nicotine compared w", "tokenized_content": [2, 9303, 3, 3872, 30, 9303, 2492, 6312, 2383, 1039, 3004, 7490, 2286, 3971, 2637, 9, 1942, 3225, 9, 2253, 9303, 2452, 65, 3]}, "items": [{"id": "p_5118", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_5119", "content": "nicotine [SEP] ACKGROUND: Nicotine polacrilex lozenges deliver 25% to 27% more nicotine compared with equivalent doses of nicotine polacrilex gum. The ", "tokenized_content": [2, 9303, 3, 2000, 23254, 3049, 30, 9303, 2492, 6312, 2383, 1039, 3004, 7490, 2286, 3971, 2637, 9, 1942, 3225, 9, 2253, 9303, 2452, 1956, 6582, 5312, 1927, 9303, 2492, 6312, 3]}, "items": [{"id": "p_5119", "content": "Nicotine [SEP] Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimu", "score": 1, "type": null, "tokenized_content": [2, 9303, 3, 9303, 1977, 3626, 6161, 29951, 18, 2176, 1977, 1920, 29183, 7829, 2019, 20239, 13908, 4086, 2597, 2176, 9602, 2801, 1032, 3]}]}
{"query": {"id": "q_5120", "content": "heart disease [SEP] multicenter, randomized, open-label study in adult smokers with heart disease, hypertension not controlled by medication, and/or diabetes mel", "tokenized_content": [2, 4003, 2573, 3, 14620, 16, 5542, 16, 4437, 17, 3954, 2161, 1922, 4160, 8112, 1956, 4003, 2573, 16, 5579, 2084, 4642, 2007, 6093, 16, 1930, 19, 2014, 4032, 4221, 3]}, "items": [{"id": "p_5120", "content": "Heart Diseases [SEP] Pathological conditions involving the HEART including its structural and functional abnormalities.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4003, 3902, 3, 6598, 2961, 5884, 1920, 4003, 2710, 2496, 4346, 1930, 3183, 6754, 18, 3]}]}
{"query": {"id": "q_5121", "content": "hypertension [SEP] ndomized, open-label study in adult smokers with heart disease, hypertension not controlled by medication, and/or diabetes mellitus. Patient", "tokenized_content": [2, 5579, 3, 8026, 1947, 2301, 16, 4437, 17, 3954, 2161, 1922, 4160, 8112, 1956, 4003, 2573, 16, 5579, 2084, 4642, 2007, 6093, 16, 1930, 19, 2014, 4032, 9695, 18, 2774, 3]}, "items": [{"id": "p_5121", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5122", "content": "diabetes mellitus [SEP] eart disease, hypertension not controlled by medication, and/or diabetes mellitus. Patients were randomized in a 1:1 ratio to receive the 4-mg ni", "tokenized_content": [2, 4032, 9695, 3, 4352, 1031, 2573, 16, 5579, 2084, 4642, 2007, 6093, 16, 1930, 19, 2014, 4032, 9695, 18, 2132, 1985, 5542, 1922, 43, 21, 30, 21, 3400, 1942, 7130, 3]}, "items": [{"id": "p_5122", "content": "Diabetes Mellitus [SEP] A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4032, 9695, 3, 43, 8538, 2210, 1927, 4414, 4378, 2007, 14022, 1930, 3817, 19202, 18, 3]}]}
{"query": {"id": "q_5123", "content": "nausea [SEP] etween the lozenge and gum. The most common adverse events were nausea (17.2% and 16.1%; 95% CI, -3.7 to 6.0), hiccups (10.7% and 6.6%", "tokenized_content": [2, 13759, 3, 2140, 2189, 1920, 3004, 7490, 2106, 1930, 20654, 18, 1920, 2501, 3059, 5246, 3916, 1985, 13759, 12, 2752, 18, 22, 9, 1930, 2641, 18, 21, 9, 31, 3002, 3]}, "items": [{"id": "p_5123", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_5124", "content": "hiccups [SEP] erse events were nausea (17.2% and 16.1%; 95% CI, -3.7 to 6.0), hiccups (10.7% and 6.6%; 95% CI, 0.5 to 7.8), and headache (8.7% and 9.", "tokenized_content": [2, 27305, 18021, 2523, 3, 22877, 1021, 3916, 1985, 13759, 12, 2752, 18, 22, 9, 1930, 2641, 18, 21, 9, 31, 3002, 9, 3371, 16, 17, 23, 18, 27, 1942, 26, 3]}, "items": [{"id": "p_5124", "content": "Hiccup [SEP] A spasm of the diaphragm that causes a sudden inhalation followed by rapid closure of the glottis which produces a sound.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27305, 18021, 1034, 3, 43, 24431, 1927, 1920, 16108, 1988, 5092, 43, 12446, 14728, 3489, 2007, 4052, 10408, 1927, 1920, 25632, 3519, 1937, 2154, 9300, 43, 8454, 18, 3]}]}
{"query": {"id": "q_5125", "content": "headache [SEP] -3.7 to 6.0), hiccups (10.7% and 6.6%; 95% CI, 0.5 to 7.8), and headache (8.7% and 9.9%; 95% Cl, -5.0 to 2.6). Serious adverse events we", "tokenized_content": [2, 12187, 3, 17, 23, 18, 27, 1942, 26, 18, 20, 13, 16, 27305, 18021, 2523, 12, 2119, 18, 27, 9, 1930, 26, 18, 26, 9, 31, 3002, 9, 3371, 16, 3]}, "items": [{"id": "p_5125", "content": "Headache [SEP] The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACH", "score": 1, "type": null, "tokenized_content": [2, 12187, 3, 1920, 3226, 1927, 3594, 1922, 1920, 13598, 3031, 18, 2176, 2278, 1998, 1925, 3937, 8867, 6564, 2014, 15570, 1927, 43, 4743, 5386, 1927, 4469, 2155, 3]}]}
{"query": {"id": "q_5126", "content": "levodopa [SEP] Development of levodopa-induced dyskinesias in parkinsonian monkeys may depend upon rat", "tokenized_content": [2, 26723, 3, 2740, 1927, 26723, 17, 2719, 3890, 26682, 1036, 1922, 10124, 3122, 11909, 2278, 4224, 4073, 3067, 3]}, "items": [{"id": "p_5126", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_5127", "content": "dyskinesias [SEP] Development of levodopa-induced dyskinesias in parkinsonian monkeys may depend upon rate of symptom onset a", "tokenized_content": [2, 3890, 26682, 1036, 3, 2740, 1927, 26723, 17, 2719, 3890, 26682, 1036, 1922, 10124, 3122, 11909, 2278, 4224, 4073, 2769, 1927, 3226, 4727, 43, 3]}, "items": [{"id": "p_5127", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5128", "content": "parkinsonian [SEP] Development of levodopa-induced dyskinesias in parkinsonian monkeys may depend upon rate of symptom onset and/or duration o", "tokenized_content": [2, 10124, 3122, 3, 2740, 1927, 26723, 17, 2719, 3890, 26682, 1036, 1922, 10124, 3122, 11909, 2278, 4224, 4073, 2769, 1927, 3226, 4727, 1930, 19, 2014, 4392, 57, 3]}, "items": [{"id": "p_5128", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_5129", "content": "Levodopa [SEP] Levodopa-induced dyskinesias (LIDs) present a major problem for the long", "tokenized_content": [2, 26723, 3, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 1036, 13, 2481, 43, 3044, 4915, 1958, 1920, 2815, 3]}, "items": [{"id": "p_5129", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_5130", "content": "dyskinesias [SEP] Levodopa-induced dyskinesias (LIDs) present a major problem for the long-term management of ", "tokenized_content": [2, 3890, 26682, 1036, 3, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 1036, 13, 2481, 43, 3044, 4915, 1958, 1920, 2815, 17, 2576, 4280, 1927, 3]}, "items": [{"id": "p_5130", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5131", "content": "LIDs [SEP] Levodopa-induced dyskinesias (LIDs) present a major problem for the long-term management of Parkin", "tokenized_content": [2, 13096, 1036, 3, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 1036, 13, 2481, 43, 3044, 4915, 1958, 1920, 2815, 17, 2576, 4280, 1927, 18337, 3]}, "items": [{"id": "p_5131", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5132", "content": "Parkinson's disease [SEP]  (LIDs) present a major problem for the long-term management of Parkinson's disease (PD) patients. Due to the interdependence of risk factors in cl", "tokenized_content": [2, 10124, 11, 61, 2573, 3, 12, 13096, 1036, 13, 2481, 43, 3044, 4915, 1958, 1920, 2815, 17, 2576, 4280, 1927, 10124, 11, 61, 2573, 12, 3203, 13, 2132, 18, 2810, 3]}, "items": [{"id": "p_5132", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_5133", "content": "PD [SEP] or problem for the long-term management of Parkinson's disease (PD) patients. Due to the interdependence of risk factors in clinic", "tokenized_content": [2, 3203, 3, 2014, 4915, 1958, 1920, 2815, 17, 2576, 4280, 1927, 10124, 11, 61, 2573, 12, 3203, 13, 2132, 18, 2810, 1942, 1920, 23521, 2200, 2055, 1927, 2565, 2790, 1922, 3]}, "items": [{"id": "p_5133", "content": "Parkinson Disease [SEP] A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency ", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 3, 43, 7529, 16, 15676, 14314, 2573, 4378, 2007, 43, 18388, 1988, 1977, 7275, 2019, 6172, 16, 7332, 1034, 12138, 12, 51, 18, 47, 18, 43, 10080, 3]}]}
{"query": {"id": "q_5134", "content": "MPTP [SEP] elopment of LIDs. Using macaque monkeys with different types of MPTP-induced parkinsonism, the current study evaluated the degree to", "tokenized_content": [2, 19043, 3, 2349, 2011, 2017, 1927, 13096, 1036, 18, 2193, 20533, 11909, 1956, 2413, 3584, 1927, 19043, 17, 2719, 26214, 16, 1920, 3214, 2161, 3747, 1920, 4647, 1942, 3]}, "items": [{"id": "p_5134", "content": "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [SEP] A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those", "score": 1, "type": null, "tokenized_content": [2, 21, 17, 4963, 17, 24, 17, 7971, 17, 21, 16, 22, 16, 23, 16, 26, 17, 21196, 18425, 5802, 3, 43, 12214, 20919, 3547, 2154, 9300, 14104, 2535, 16, 4399, 16, 1930, 6598, 5996, 1988, 10223, 2690, 3]}]}
{"query": {"id": "q_5135", "content": "parkinsonism [SEP] IDs. Using macaque monkeys with different types of MPTP-induced parkinsonism, the current study evaluated the degree to which rate of sympto", "tokenized_content": [2, 26214, 3, 20727, 18, 2193, 20533, 11909, 1956, 2413, 3584, 1927, 19043, 17, 2719, 26214, 16, 1920, 3214, 2161, 3747, 1920, 4647, 1942, 2154, 2769, 1927, 29148, 4575, 3]}, "items": [{"id": "p_5135", "content": "Parkinson Disease, Secondary [SEP] Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected co", "score": 1, "type": null, "tokenized_content": [2, 10124, 2573, 16, 4067, 3, 2961, 2154, 5961, 2535, 10952, 18994, 3065, 10124, 2573, 1988, 2032, 4189, 2007, 43, 3171, 2014, 9407, 2081, 3]}]}
{"query": {"id": "q_5136", "content": "levodopa [SEP]  progression, symptom severity, and response to and duration of levodopa therapy may be involved in the development of LIDs. Monkeys wit", "tokenized_content": [2, 26723, 3, 4380, 16, 3226, 5155, 16, 1930, 2644, 1942, 1930, 4392, 1927, 26723, 3181, 2278, 1998, 3286, 1922, 1920, 2740, 1927, 13096, 1036, 18, 11909, 16086, 3]}, "items": [{"id": "p_5136", "content": "Levodopa [SEP] The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can b", "score": 1, "type": null, "tokenized_content": [2, 26723, 3, 1920, 10414, 6966, 2386, 1927, 20684, 17616, 2199, 15769, 1930, 1920, 8426, 7897, 1927, 7964, 18, 7945, 7964, 6999, 16, 2176, 2112, 44, 3]}]}
{"query": {"id": "q_5137", "content": "dyskinesia [SEP] Levodopa-induced dyskinesias (LIDs) present a major problem for the long-term management of", "tokenized_content": [2, 3890, 26682, 3, 26723, 17, 2719, 3890, 26682, 1036, 12, 13096, 1036, 13, 2481, 43, 3044, 4915, 1958, 1920, 2815, 17, 2576, 4280, 1927, 3]}, "items": [{"id": "p_5137", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5138", "content": "Propylthiouracil [SEP] Propylthiouracil-induced perinuclear-staining antineutrophil cytoplasmic autoant", "tokenized_content": [2, 20299, 22523, 20122, 3, 20299, 22523, 20122, 17, 2719, 23907, 17, 4166, 29128, 4092, 4748, 6823, 12602, 1031, 3]}, "items": [{"id": "p_5138", "content": "Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro", "score": 1, "type": null, "tokenized_content": [2, 20299, 22523, 20122, 3, 43, 15331, 16648, 10310, 30338, 12245, 5899, 18, 5062, 4626, 3940, 9280, 10401, 7042, 1920, 4271, 1927, 29423, 1930, 7042, 1920, 5009, 7309, 1927, 21980, 3]}]}
{"query": {"id": "q_5139", "content": "vasculitis [SEP] clear-staining antineutrophil cytoplasmic autoantibody-positive vasculitis in conjunction with pericarditis.", "tokenized_content": [2, 21548, 3, 4021, 17, 4166, 29128, 4092, 4748, 6823, 23852, 17, 2843, 21548, 1922, 11799, 1956, 10796, 3082, 3600, 18, 3]}, "items": [{"id": "p_5139", "content": "Vasculitis [SEP] Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.\n   ", "score": 1, "type": null, "tokenized_content": [2, 21548, 3, 4531, 1927, 2967, 2340, 1927, 1920, 2877, 7208, 16, 2710, 1920, 9345, 31, 14785, 31, 1930, 6172, 1927, 1920, 13040, 2433, 1922, 1920, 3362, 18, 3]}]}
{"query": {"id": "q_5140", "content": "pericarditis [SEP] ytoplasmic autoantibody-positive vasculitis in conjunction with pericarditis.", "tokenized_content": [2, 10796, 3082, 3600, 3, 24412, 11302, 23852, 17, 2843, 21548, 1922, 11799, 1956, 10796, 3082, 3600, 18, 3]}, "items": [{"id": "p_5140", "content": "Pericarditis [SEP] Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced", "score": 1, "type": null, "tokenized_content": [2, 10796, 3082, 3600, 3, 4531, 1927, 1920, 10796, 26872, 2037, 3425, 13538, 16, 2427, 1966, 2909, 16, 12132, 16, 8904, 2585, 16, 8209, 16, 2014, 2838, 17, 2719, 3]}]}
{"query": {"id": "q_5141", "content": "propylthiouracil [SEP] OBJECTIVE: To describe a case of propylthiouracil-induced vasculitis manifesting with pericarditis. METHODS: We p", "tokenized_content": [2, 20299, 22523, 20122, 3, 4470, 30, 1942, 5993, 43, 3087, 1927, 20299, 22523, 20122, 17, 2719, 21548, 7943, 1941, 1956, 10796, 3082, 3600, 18, 2860, 30, 2038, 58, 3]}, "items": [{"id": "p_5141", "content": "Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro", "score": 1, "type": null, "tokenized_content": [2, 20299, 22523, 20122, 3, 43, 15331, 16648, 10310, 30338, 12245, 5899, 18, 5062, 4626, 3940, 9280, 10401, 7042, 1920, 4271, 1927, 29423, 1930, 7042, 1920, 5009, 7309, 1927, 21980, 3]}]}
{"query": {"id": "q_5142", "content": "vasculitis [SEP] OBJECTIVE: To describe a case of propylthiouracil-induced vasculitis manifesting with pericarditis. METHODS: We present the first ca", "tokenized_content": [2, 21548, 3, 4470, 30, 1942, 5993, 43, 3087, 1927, 20299, 22523, 20122, 17, 2719, 21548, 7943, 1941, 1956, 10796, 3082, 3600, 18, 2860, 30, 2038, 2481, 1920, 2561, 2332, 3]}, "items": [{"id": "p_5142", "content": "Vasculitis [SEP] Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.\n   ", "score": 1, "type": null, "tokenized_content": [2, 21548, 3, 4531, 1927, 2967, 2340, 1927, 1920, 2877, 7208, 16, 2710, 1920, 9345, 31, 14785, 31, 1930, 6172, 1927, 1920, 13040, 2433, 1922, 1920, 3362, 18, 3]}]}
{"query": {"id": "q_5143", "content": "pericarditis [SEP]  a case of propylthiouracil-induced vasculitis manifesting with pericarditis. METHODS: We present the first case report of a woman with hype", "tokenized_content": [2, 10796, 3082, 3600, 3, 43, 3087, 1927, 20299, 22523, 20122, 17, 2719, 21548, 7943, 1941, 1956, 10796, 3082, 3600, 18, 2860, 30, 2038, 2481, 1920, 2561, 3087, 3809, 1927, 43, 3]}, "items": [{"id": "p_5143", "content": "Pericarditis [SEP] Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced", "score": 1, "type": null, "tokenized_content": [2, 10796, 3082, 3600, 3, 4531, 1927, 1920, 10796, 26872, 2037, 3425, 13538, 16, 2427, 1966, 2909, 16, 12132, 16, 8904, 2585, 16, 8209, 16, 2014, 2838, 17, 2719, 3]}]}
{"query": {"id": "q_5144", "content": "hyperthyroidism [SEP] itis. METHODS: We present the first case report of a woman with hyperthyroidism treated with propylthiouracil in whom a syndrome of pericarditi", "tokenized_content": [2, 28413, 3, 2176, 1937, 18, 2860, 30, 2038, 2481, 1920, 2561, 3087, 3809, 1927, 43, 10440, 1956, 28413, 2868, 1956, 20299, 22523, 20122, 1922, 8566, 43, 4741, 1927, 10796, 3082, 3]}, "items": [{"id": "p_5144", "content": "Hyperthyroidism [SEP] Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.\n  ", "score": 1, "type": null, "tokenized_content": [2, 28413, 3, 10694, 1940, 10411, 2001, 1927, 6918, 10224, 2037, 1920, 6918, 8359, 18, 4664, 2428, 1927, 6918, 10224, 2760, 5342, 4487, 2769, 18, 3]}]}
{"query": {"id": "q_5145", "content": "fever [SEP] eated with propylthiouracil in whom a syndrome of pericarditis, fever, and glomerulonephritis developed. Serologic testing and immuno", "tokenized_content": [2, 9087, 3, 13619, 1919, 1956, 20299, 22523, 20122, 1922, 8566, 43, 4741, 1927, 10796, 3082, 3600, 16, 9087, 16, 1930, 27057, 3530, 18, 27551, 4213, 1930, 6595, 3]}, "items": [{"id": "p_5145", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_5146", "content": "glomerulonephritis [SEP] propylthiouracil in whom a syndrome of pericarditis, fever, and glomerulonephritis developed. Serologic testing and immunologic studies were done,", "tokenized_content": [2, 27057, 3, 20299, 22523, 20122, 1922, 8566, 43, 4741, 1927, 10796, 3082, 3600, 16, 9087, 16, 1930, 27057, 3530, 18, 27551, 4213, 1930, 21049, 2351, 1985, 5404, 16, 3]}, "items": [{"id": "p_5146", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_5147", "content": "Graves' disease [SEP] cardial biopsy was performed. RESULTS: A 25-year-old woman with Graves' disease had a febrile illness and evidence of pericarditis, which was c", "tokenized_content": [2, 30066, 11, 2573, 3, 3215, 1923, 6831, 1982, 2593, 18, 2274, 30, 43, 2637, 17, 2476, 17, 4156, 10440, 1956, 30066, 11, 2573, 2430, 43, 18850, 6455, 1930, 3095, 1927, 3]}, "items": [{"id": "p_5147", "content": "Graves Disease [SEP] A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies again", "score": 1, "type": null, "tokenized_content": [2, 30066, 2573, 3, 43, 3059, 2386, 1927, 28413, 1956, 43, 9435, 28733, 3611, 2997, 18, 2176, 1977, 1925, 8904, 4770, 1988, 9300, 3788, 3116, 3]}]}
{"query": {"id": "q_5148", "content": "febrile illness [SEP] formed. RESULTS: A 25-year-old woman with Graves' disease had a febrile illness and evidence of pericarditis, which was confirmed by biopsy. Se", "tokenized_content": [2, 18850, 6455, 3, 5333, 18, 2274, 30, 43, 2637, 17, 2476, 17, 4156, 10440, 1956, 30066, 11, 2573, 2430, 43, 18850, 6455, 1930, 3095, 1927, 10796, 3082, 3600, 16, 2154, 3]}, "items": [{"id": "p_5148", "content": "Fever [SEP] An abnormal elevation of body temperature, usually as a result of a pathologic process.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9087, 3, 1925, 4552, 8644, 1927, 3362, 3449, 16, 5394, 1966, 43, 3211, 1927, 43, 11896, 2585, 18, 3]}]}
{"query": {"id": "q_5149", "content": "Propylthiouracil [SEP] toplasmic autoantibodies (pANCA) against myeloperoxidase (MPO). Propylthiouracil therapy was withdrawn, and she was treated with a 1-month cours", "tokenized_content": [2, 20299, 22523, 20122, 3, 3700, 24605, 4913, 15510, 12, 5001, 1019, 13, 3316, 28106, 12, 18278, 13, 18, 20299, 22523, 20122, 3181, 1982, 19540, 16, 1930, 4693, 1982, 2868, 1956, 3]}, "items": [{"id": "p_5149", "content": "Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro", "score": 1, "type": null, "tokenized_content": [2, 20299, 22523, 20122, 3, 43, 15331, 16648, 10310, 30338, 12245, 5899, 18, 5062, 4626, 3940, 9280, 10401, 7042, 1920, 4271, 1927, 29423, 1930, 7042, 1920, 5009, 7309, 1927, 21980, 3]}]}
{"query": {"id": "q_5150", "content": "prednisone [SEP] apy was withdrawn, and she was treated with a 1-month course of prednisone, which alleviated her symptoms. A literature review revealed no", "tokenized_content": [2, 20405, 3, 2100, 1012, 1982, 19540, 16, 1930, 4693, 1982, 2868, 1956, 43, 21, 17, 2935, 4914, 1927, 20405, 16, 2154, 24228, 3656, 3601, 18, 43, 4431, 3043, 3404, 2239, 3]}, "items": [{"id": "p_5150", "content": "Prednisone [SEP] A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in t", "score": 1, "type": null, "tokenized_content": [2, 20405, 3, 43, 6830, 2246, 17, 3769, 14469, 3595, 2037, 18964, 8142, 1021, 18, 2176, 1977, 12186, 22937, 1930, 9076, 1942, 22025, 1922, 62, 3]}]}
{"query": {"id": "q_5151", "content": "propylthio- uracil [SEP] icarditis in anti-MPO pANCA-positive vasculitis associated with propylthio- uracil therapy. CONCLUSION: Pericarditis may be the initial manifestat", "tokenized_content": [2, 20299, 22523, 1037, 17, 22761, 3, 14784, 8544, 3678, 1922, 2246, 17, 18278, 5001, 1019, 17, 2843, 21548, 2458, 1956, 20299, 22523, 1037, 17, 22761, 3181, 18, 4180, 30, 10796, 3]}, "items": [{"id": "p_5151", "content": "Propylthiouracil [SEP] A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of thro", "score": 1, "type": null, "tokenized_content": [2, 20299, 22523, 20122, 3, 43, 15331, 16648, 10310, 30338, 12245, 5899, 18, 5062, 4626, 3940, 9280, 10401, 7042, 1920, 4271, 1927, 29423, 1930, 7042, 1920, 5009, 7309, 1927, 21980, 3]}]}
{"query": {"id": "q_5152", "content": "Pericarditis [SEP] culitis associated with propylthio- uracil therapy. CONCLUSION: Pericarditis may be the initial manifestation of drug-induced vasculitis att", "tokenized_content": [2, 10796, 3082, 3600, 3, 6710, 3678, 2458, 1956, 20299, 22523, 1037, 17, 22761, 3181, 18, 4180, 30, 10796, 3082, 3600, 2278, 1998, 1920, 3754, 15570, 1927, 2838, 17, 2719, 21548, 3]}, "items": [{"id": "p_5152", "content": "Pericarditis [SEP] Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced", "score": 1, "type": null, "tokenized_content": [2, 10796, 3082, 3600, 3, 4531, 1927, 1920, 10796, 26872, 2037, 3425, 13538, 16, 2427, 1966, 2909, 16, 12132, 16, 8904, 2585, 16, 8209, 16, 2014, 2838, 17, 2719, 3]}]}
{"query": {"id": "q_5153", "content": "beta-carboline [SEP] Two mouse lines selected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various p", "tokenized_content": [2, 4666, 17, 3697, 8419, 3, 2288, 3321, 3557, 3790, 1958, 5611, 18530, 1942, 4666, 17, 3697, 8419, 17, 2719, 10060, 2032, 2222, 7218, 4532, 1942, 3425, 58, 3]}, "items": [{"id": "p_5153", "content": "beta-carboline-3-carboxylic acid methyl ester [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 3697, 8419, 17, 23, 17, 18708, 2687, 4963, 9603, 3, 3]}]}
{"query": {"id": "q_5154", "content": "seizures [SEP] lected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various pharmacological ef", "tokenized_content": [2, 10060, 3, 17533, 1919, 1958, 5611, 18530, 1942, 4666, 17, 3697, 8419, 17, 2719, 10060, 2032, 2222, 7218, 4532, 1942, 3425, 7683, 8485, 3]}, "items": [{"id": "p_5154", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5155", "content": "GABA [SEP] rentially sensitive to various pharmacological effects of other GABA(A) receptor ligands.", "tokenized_content": [2, 7992, 3, 3866, 5093, 4532, 1942, 3425, 7683, 2564, 1927, 2303, 7992, 12, 43, 13, 3148, 6908, 18, 3]}, "items": [{"id": "p_5155", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_5156", "content": "seizures [SEP] rding to their sensitivity (BS line) or resistance (BR line) to seizures induced by a single i.p. injection of methyl beta-carboline-3-c", "tokenized_content": [2, 10060, 3, 8695, 1941, 1942, 2310, 3802, 12, 8242, 2823, 13, 2014, 3554, 12, 2387, 2823, 13, 1942, 10060, 2719, 2007, 43, 2957, 51, 18, 58, 18, 4107, 1927, 4963, 3]}, "items": [{"id": "p_5156", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5157", "content": "methyl beta-carboline-3-carboxylate [SEP] nce (BR line) to seizures induced by a single i.p. injection of methyl beta-carboline-3-carboxylate (beta-CCM), an inverse agonist of the GABA(A) receptor benzodia", "tokenized_content": [2, 4963, 4666, 17, 3697, 8419, 17, 23, 17, 20877, 3, 5301, 1021, 12, 2387, 2823, 13, 1942, 10060, 2719, 2007, 43, 2957, 51, 18, 58, 18, 4107, 1927, 4963, 4666, 3]}, "items": [{"id": "p_5157", "content": "beta-carboline-3-carboxylic acid methyl ester [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 3697, 8419, 17, 23, 17, 18708, 2687, 4963, 9603, 3, 3]}]}
{"query": {"id": "q_5158", "content": "beta-CCM [SEP] a single i.p. injection of methyl beta-carboline-3-carboxylate (beta-CCM), an inverse agonist of the GABA(A) receptor benzodiazepine sit", "tokenized_content": [2, 4666, 17, 25993, 3, 43, 2957, 51, 18, 58, 18, 4107, 1927, 4963, 4666, 17, 3697, 8419, 17, 23, 17, 20877, 12, 4666, 17, 25993, 13, 16, 1925, 9526, 7829, 3]}, "items": [{"id": "p_5158", "content": "beta-carboline-3-carboxylic acid methyl ester [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 4666, 17, 3697, 8419, 17, 23, 17, 18708, 2687, 4963, 9603, 3, 3]}]}
{"query": {"id": "q_5159", "content": "GABA [SEP] a-carboline-3-carboxylate (beta-CCM), an inverse agonist of the GABA(A) receptor benzodiazepine site. Our aim was to characterize bo", "tokenized_content": [2, 7992, 3, 43, 17, 3697, 8419, 17, 23, 17, 20877, 12, 4666, 17, 25993, 13, 16, 1925, 9526, 7829, 1927, 1920, 7992, 12, 43, 13, 3148, 27266, 3200, 18, 2342, 3]}, "items": [{"id": "p_5159", "content": "gamma-Aminobutyric Acid [SEP] The most common inhibitory neurotransmitter in the central nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7034, 17, 29093, 2687, 3, 1920, 2501, 3059, 5431, 15223, 1922, 1920, 4101, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_5160", "content": "benzodiazepine [SEP] boxylate (beta-CCM), an inverse agonist of the GABA(A) receptor benzodiazepine site. Our aim was to characterize both lines' sensitivities to ", "tokenized_content": [2, 27266, 3, 5758, 9075, 12, 4666, 17, 25993, 13, 16, 1925, 9526, 7829, 1927, 1920, 7992, 12, 43, 13, 3148, 27266, 3200, 18, 2342, 3774, 1982, 1942, 8063, 2321, 3557, 3]}, "items": [{"id": "p_5160", "content": "Benzodiazepines [SEP] A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.\n    ", "score": 1, "type": null, "tokenized_content": [2, 26555, 3, 43, 2210, 1927, 2288, 17, 6335, 27804, 13153, 4300, 7600, 1927, 43, 18536, 6335, 10305, 1942, 43, 25312, 2053, 6335, 18, 3]}]}
{"query": {"id": "q_5161", "content": "diazepam [SEP] l effects of other ligands of the GABA(A) receptor. We measured diazepam-induced anxiolysis with the elevated plus-maze test, diazepam-i", "tokenized_content": [2, 26079, 3, 54, 2564, 1927, 2303, 6908, 1927, 1920, 7992, 12, 43, 13, 3148, 18, 2038, 3045, 26079, 17, 2719, 24400, 6892, 1956, 1920, 4664, 5390, 17, 14476, 2648, 16, 3]}, "items": [{"id": "p_5161", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_5162", "content": "picrotoxin [SEP] iazepam-induced sedation by recording the vigilance states, and picrotoxin- and pentylenetetrazol-induced seizures after i.p. injections. ", "tokenized_content": [2, 7271, 6843, 9754, 3, 11640, 6931, 4302, 1035, 17, 2719, 15263, 2007, 6340, 1920, 27097, 4376, 16, 1930, 7271, 6843, 9754, 17, 1930, 9412, 6752, 14278, 21193, 13642, 1024, 17, 3]}, "items": [{"id": "p_5162", "content": "Picrotoxin [SEP] A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated c", "score": 1, "type": null, "tokenized_content": [2, 7271, 6843, 9754, 3, 43, 22849, 9626, 2572, 2320, 8151, 2019, 7992, 17, 43, 4086, 1930, 2842, 43, 4772, 6325, 2031, 18, 7271, 6843, 9754, 7644, 1920, 7034, 17, 29093, 2687, 17, 4128, 45, 3]}]}
{"query": {"id": "q_5163", "content": "pentylenetetrazol [SEP] sedation by recording the vigilance states, and picrotoxin- and pentylenetetrazol-induced seizures after i.p. injections. Results presented here ", "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1024, 3, 15263, 2007, 6340, 1920, 27097, 4376, 16, 1930, 7271, 6843, 9754, 17, 1930, 9412, 6752, 14278, 21193, 13642, 1024, 17, 2719, 10060, 2256, 3]}, "items": [{"id": "p_5163", "content": "Pentylenetetrazole [SEP] A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-comp", "score": 1, "type": null, "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 43, 11106, 5899, 1988, 10750, 2455, 1966, 43, 4101, 7580, 2433, 1930, 5481, 24252, 18, 2176, 1977, 3311, 43, 2447, 17, 2059, 3]}]}
{"query": {"id": "q_5164", "content": "ketamine [SEP] Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlle", "tokenized_content": [2, 14049, 3, 14501, 2495, 1927, 7307, 14049, 1922, 2539, 2132, 1990, 11553, 3181, 30, 43, 5542, 16, 2285, 1952, 3]}, "items": [{"id": "p_5164", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_5165", "content": "cancer [SEP] Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-", "tokenized_content": [2, 2539, 3, 14501, 2495, 1927, 7307, 14049, 1922, 2539, 2132, 1990, 11553, 3181, 30, 43, 5542, 16, 4642, 16, 4825, 17, 3]}, "items": [{"id": "p_5165", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5166", "content": "morphine [SEP] Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-blind, crossover, dou", "tokenized_content": [2, 11553, 3, 14501, 2495, 1927, 7307, 14049, 1922, 2539, 2132, 1990, 11553, 3181, 30, 43, 5542, 16, 4642, 16, 4825, 17, 7109, 16, 15845, 16, 2608, 1032, 3]}, "items": [{"id": "p_5166", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_5167", "content": "Pain [SEP] Pain not responsive to morphine is often problematic. Animal and cli", "tokenized_content": [2, 3594, 3, 3594, 2084, 8487, 1942, 11553, 1977, 3868, 13624, 18, 4027, 1930, 2111, 1033, 3]}, "items": [{"id": "p_5167", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_5168", "content": "morphine [SEP] Pain not responsive to morphine is often problematic. Animal and clinical studies have suggeste", "tokenized_content": [2, 11553, 3, 3594, 2084, 8487, 1942, 11553, 1977, 3868, 13624, 18, 4027, 1930, 2535, 2351, 2162, 3220, 1021, 3]}, "items": [{"id": "p_5168", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_5169", "content": "N-methyl-D-aspartate [SEP] en problematic. Animal and clinical studies have suggested that N-methyl-D-aspartate (NMDA) antagonists, such as ketamine, may be effective in impro", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 2066, 13624, 18, 4027, 1930, 2535, 2351, 2162, 3978, 1988, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 10515, 16, 3]}, "items": [{"id": "p_5169", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_5170", "content": "NMDA [SEP]  and clinical studies have suggested that N-methyl-D-aspartate (NMDA) antagonists, such as ketamine, may be effective in improving o", "tokenized_content": [2, 10976, 3, 1930, 2535, 2351, 2162, 3978, 1988, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 10515, 16, 2427, 1966, 14049, 16, 2278, 1998, 3655, 1922, 7440, 57, 3]}, "items": [{"id": "p_5170", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_5171", "content": "ketamine [SEP] suggested that N-methyl-D-aspartate (NMDA) antagonists, such as ketamine, may be effective in improving opioid analgesia in difficult pa", "tokenized_content": [2, 14049, 3, 3978, 1988, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 10515, 16, 2427, 1966, 14049, 16, 2278, 1998, 3655, 1922, 7440, 9384, 14695, 1922, 4571, 3838, 3]}, "items": [{"id": "p_5171", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_5172", "content": "pain [SEP] ne, may be effective in improving opioid analgesia in difficult pain syndromes, such as neuropathic pain. A slow bolus of subhypnoti", "tokenized_content": [2, 3594, 3, 2069, 16, 2278, 1998, 3655, 1922, 7440, 9384, 14695, 1922, 4571, 3594, 12688, 16, 2427, 1966, 16591, 3594, 18, 43, 5470, 14840, 1927, 2316, 30338, 27257, 13323, 3]}, "items": [{"id": "p_5172", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_5173", "content": "neuropathic pain [SEP] improving opioid analgesia in difficult pain syndromes, such as neuropathic pain. A slow bolus of subhypnotic doses of ketamine (0.25 mg/kg or 0", "tokenized_content": [2, 16591, 3594, 3, 7440, 9384, 14695, 1922, 4571, 3594, 12688, 16, 2427, 1966, 16591, 3594, 18, 43, 5470, 14840, 1927, 2316, 30338, 27257, 3153, 5312, 1927, 14049, 12, 20, 18, 3]}, "items": [{"id": "p_5173", "content": "Neuralgia [SEP] Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5181, 11966, 3, 10702, 2014, 3546, 1941, 3594, 1988, 5110, 4231, 1920, 4914, 2014, 3282, 1927, 43, 5009, 2014, 13598, 5507, 18, 3]}]}
{"query": {"id": "q_5174", "content": "cancer [SEP] ic doses of ketamine (0.25 mg/kg or 0.50 mg/kg) was given to 10 cancer patients whose pain was unrelieved by morphine in a randomized,", "tokenized_content": [2, 2539, 3, 3996, 5312, 1927, 14049, 12, 20, 18, 2637, 2786, 19, 3621, 2014, 20, 18, 2761, 2786, 19, 3621, 13, 1982, 3258, 1942, 2119, 2539, 2132, 6098, 3594, 1982, 3]}, "items": [{"id": "p_5174", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5175", "content": "nausea [SEP] double-dose study. Pain intensity on a 0 to 10 numerical scale; nausea and vomiting, drowsiness, confusion, and dry mouth, using a sca", "tokenized_content": [2, 13759, 3, 4825, 17, 3253, 2161, 18, 3594, 4266, 1990, 43, 20, 1942, 2119, 10197, 3536, 31, 13759, 1930, 13954, 16, 29247, 6777, 1979, 16, 18272, 16, 1930, 7143, 11701, 3]}, "items": [{"id": "p_5175", "content": "Nausea [SEP] An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and moti", "score": 1, "type": null, "tokenized_content": [2, 13759, 3, 1925, 25429, 15826, 1922, 1920, 11399, 5394, 7936, 2007, 1920, 11460, 1021, 1942, 13463, 1932, 18, 3059, 5092, 2032, 3120, 5284, 16, 9309, 1930, 12798, 1033, 3]}]}
{"query": {"id": "q_5176", "content": "vomiting [SEP]  study. Pain intensity on a 0 to 10 numerical scale; nausea and vomiting, drowsiness, confusion, and dry mouth, using a scale from 0 to ", "tokenized_content": [2, 13954, 3, 2161, 18, 3594, 4266, 1990, 43, 20, 1942, 2119, 10197, 3536, 31, 13759, 1930, 13954, 16, 29247, 6777, 1979, 16, 18272, 16, 1930, 7143, 11701, 16, 2193, 43, 3]}, "items": [{"id": "p_5176", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_5177", "content": "confusion [SEP]  on a 0 to 10 numerical scale; nausea and vomiting, drowsiness, confusion, and dry mouth, using a scale from 0 to 3 (not at all, slight, ", "tokenized_content": [2, 18272, 3, 1990, 43, 20, 1942, 2119, 10197, 3536, 31, 13759, 1930, 13954, 16, 29247, 6777, 1979, 16, 18272, 16, 1930, 7143, 11701, 16, 2193, 43, 3536, 2037, 20, 1942, 3]}, "items": [{"id": "p_5177", "content": "Confusion [SEP] A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18272, 3, 43, 5018, 3360, 4378, 2007, 1998, 17045, 4184, 2166, 1939, 16, 6687, 12732, 16, 3630, 1927, 4021, 14778, 16, 1930, 12365, 2054, 29292, 18, 3]}]}
{"query": {"id": "q_5178", "content": "dry mouth [SEP] umerical scale; nausea and vomiting, drowsiness, confusion, and dry mouth, using a scale from 0 to 3 (not at all, slight, a lot, awful); ", "tokenized_content": [2, 7143, 11701, 3, 8736, 21052, 1024, 3536, 31, 13759, 1930, 13954, 16, 29247, 6777, 1979, 16, 18272, 16, 1930, 7143, 11701, 16, 2193, 43, 3536, 2037, 20, 1942, 23, 12, 3]}, "items": [{"id": "p_5178", "content": "Xerostomia [SEP] Decreased salivary flow.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27833, 28009, 2126, 3, 3261, 11866, 3426, 18, 3]}]}
{"query": {"id": "q_5179", "content": "Ketamine [SEP] , 60 minutes (T60), 120 minutes (T120), and 180 minutes (T180). Ketamine, but not saline solution, significantly reduced the pain intens", "tokenized_content": [2, 14049, 3, 16, 3276, 4814, 12, 20762, 1008, 13, 16, 6103, 4814, 12, 6197, 3520, 13, 16, 1930, 8585, 4814, 12, 6197, 4476, 13, 18, 14049, 16, 2308, 2084, 5977, 3]}, "items": [{"id": "p_5179", "content": "Ketamine [SEP] A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can bl", "score": 1, "type": null, "tokenized_content": [2, 14049, 3, 43, 22724, 28649, 10533, 2251, 1958, 4408, 1927, 8871, 18, 2496, 2856, 1927, 4615, 1977, 2084, 2486, 7372, 16, 2308, 14049, 2112, 2266, 3]}]}
{"query": {"id": "q_5180", "content": "Hallucinations [SEP] effect was more relevant in patients treated with higher doses. Hallucinations occurred in 4 patients, and an unpleasant sensation (\"empty hea", "tokenized_content": [2, 27013, 3, 2495, 1982, 2253, 4494, 1922, 2132, 2868, 1956, 2580, 5312, 18, 27013, 4807, 1922, 24, 2132, 16, 1930, 1925, 25429, 15826, 12, 6, 10494, 2234, 1019, 3]}, "items": [{"id": "p_5180", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_5181", "content": "diazepam [SEP] 2 patients. These episodes reversed after the administration of diazepam 1 mg intravenously. Significant increases in drowsiness were re", "tokenized_content": [2, 26079, 3, 22, 2132, 18, 2144, 9232, 9432, 2256, 1920, 4183, 1927, 26079, 21, 2786, 15132, 18, 2228, 4041, 1922, 29247, 6777, 1979, 1985, 1964, 3]}, "items": [{"id": "p_5181", "content": "Diazepam [SEP] A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of actio", "score": 1, "type": null, "tokenized_content": [2, 26079, 3, 43, 27266, 1956, 26572, 2031, 16, 28932, 16, 28514, 16, 3760, 7327, 2031, 16, 1930, 14701, 18522, 1030, 3879, 1930, 43, 2815, 4392, 1927, 4033, 3940, 3]}]}
{"query": {"id": "q_5182", "content": "erectile dysfunction [SEP] Endocrine screening in 1,022 men with erectile dysfunction: clinical significance and cost-effective strategy.", "tokenized_content": [2, 24686, 5273, 3, 10749, 4449, 1922, 21, 16, 19983, 3925, 1956, 24686, 5273, 30, 2535, 4550, 1930, 4455, 17, 3655, 4884, 18, 3]}, "items": [{"id": "p_5182", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_5183", "content": "testosterone [SEP] PURPOSE: We reviewed the results of serum testosterone and prolactin determination in 1,022 patients referred because ", "tokenized_content": [2, 10592, 3, 5120, 30, 2038, 5487, 1920, 2274, 1927, 3256, 10592, 1930, 18386, 7063, 1922, 21, 16, 19983, 2132, 6656, 2882, 3]}, "items": [{"id": "p_5183", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_5184", "content": "erectile dysfunction [SEP] d prolactin determination in 1,022 patients referred because of erectile dysfunction and compared the data with history, results of physical examina", "tokenized_content": [2, 24686, 5273, 3, 46, 18386, 7063, 1922, 21, 16, 19983, 2132, 6656, 2882, 1927, 24686, 5273, 1930, 2452, 1920, 2230, 1956, 4403, 16, 2274, 1927, 3841, 2493, 4058, 3]}, "items": [{"id": "p_5184", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_5185", "content": "Testosterone [SEP] sponsibility for hormonal abnormalities. MATERIALS AND METHODS: Testosterone and prolactin were determined by radioimmunoassay. Every patien", "tokenized_content": [2, 10592, 3, 15312, 3687, 1958, 12438, 6754, 18, 4751, 1930, 2860, 30, 10592, 1930, 18386, 1985, 3180, 2007, 26628, 18, 4808, 2091, 1917, 3]}, "items": [{"id": "p_5185", "content": "Testosterone [SEP] A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEIN", "score": 1, "type": null, "tokenized_content": [2, 10592, 3, 43, 6828, 10817, 1935, 9507, 1930, 3044, 4863, 8366, 2007, 1920, 27509, 2094, 1927, 1920, 13205, 18, 2496, 3372, 1977, 5449, 2007, 21600, 3]}]}
{"query": {"id": "q_5186", "content": "low sexual desire [SEP] estosterone and 451 were screened for prolactin on the basis of low sexual desire, gynecomastia or testosterone less than 4 ng./ml. Determination", "tokenized_content": [2, 2330, 5702, 15917, 3, 3255, 7983, 1930, 26401, 1985, 8582, 1958, 18386, 1990, 1920, 4859, 1927, 2330, 5702, 15917, 16, 14662, 4956, 11574, 2014, 10592, 2941, 2254, 24, 4375, 18, 3]}, "items": [{"id": "p_5186", "content": "Sexual Dysfunctions, Psychological [SEP] Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked dis", "score": 1, "type": null, "tokenized_content": [2, 5702, 24199, 16, 6674, 3, 12654, 1922, 5702, 15917, 1930, 1920, 21180, 12649, 2840, 1988, 8063, 1920, 5702, 2644, 4048, 1930, 3936, 4961, 2054, 3]}]}
{"query": {"id": "q_5187", "content": "gynecomastia [SEP]  were screened for prolactin on the basis of low sexual desire, gynecomastia or testosterone less than 4 ng./ml. Determination was repeated ", "tokenized_content": [2, 14662, 4956, 11574, 3, 1985, 8582, 1958, 18386, 1990, 1920, 4859, 1927, 2330, 5702, 15917, 16, 14662, 4956, 11574, 2014, 10592, 2941, 2254, 24, 4375, 18, 19, 2646, 18, 7063, 3]}, "items": [{"id": "p_5187", "content": "Gynecomastia [SEP] Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEW", "score": 1, "type": null, "tokenized_content": [2, 14662, 4956, 11574, 3, 16363, 1927, 1920, 3739, 1922, 1920, 5129, 16, 4189, 2007, 1925, 5799, 1927, 20470, 18, 5005, 14662, 4956, 11574, 1977, 7885, 2528, 1922, 2814, 3]}]}
{"query": {"id": "q_5188", "content": "testosterone heptylate [SEP] , small testes and gynecomastia. Endocrine therapy consisted of testosterone heptylate or human chorionic gonadotropin for hypogonadism and bromocript", "tokenized_content": [2, 10592, 20662, 9075, 3, 16, 2858, 16880, 1930, 14662, 4956, 11574, 18, 10749, 3181, 6994, 1927, 10592, 20662, 9075, 2014, 2616, 28776, 21704, 1958, 28650, 2421, 1930, 21392, 4093, 3]}, "items": [{"id": "p_5188", "content": "testosterone enanthate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 10592, 2066, 7744, 2010, 3, 3]}]}
{"query": {"id": "q_5189", "content": "hypogonadism [SEP] d of testosterone heptylate or human chorionic gonadotropin for hypogonadism and bromocriptine for hyperprolactinemia. RESULTS: Testosterone", "tokenized_content": [2, 28650, 2421, 3, 46, 1927, 10592, 20662, 9075, 2014, 2616, 28776, 21704, 1958, 28650, 2421, 1930, 21392, 4093, 2053, 1958, 4194, 15743, 11686, 3847, 18, 2274, 30, 10592, 3]}, "items": [{"id": "p_5189", "content": "Hypogonadism [SEP] Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It i", "score": 1, "type": null, "tokenized_content": [2, 28650, 2421, 3, 2625, 3864, 2037, 5778, 21282, 4088, 16, 2427, 1966, 21009, 3761, 1930, 1920, 3372, 1927, 21282, 9507, 10224, 18, 2176, 51, 3]}]}
{"query": {"id": "q_5190", "content": "bromocriptine [SEP]  heptylate or human chorionic gonadotropin for hypogonadism and bromocriptine for hyperprolactinemia. RESULTS: Testosterone was less than 3 n", "tokenized_content": [2, 21392, 4093, 2053, 3, 20662, 9075, 2014, 2616, 28776, 21704, 1958, 28650, 2421, 1930, 21392, 4093, 2053, 1958, 4194, 15743, 11686, 3847, 18, 2274, 30, 10592, 1982, 2941, 2254, 23, 3]}, "items": [{"id": "p_5190", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_5191", "content": "hyperprolactinemia [SEP] n chorionic gonadotropin for hypogonadism and bromocriptine for hyperprolactinemia. RESULTS: Testosterone was less than 3 ng./ml. in 107 patients ", "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 56, 28776, 21704, 1958, 28650, 2421, 1930, 21392, 4093, 2053, 1958, 4194, 15743, 11686, 3847, 18, 2274, 30, 10592, 1982, 2941, 2254, 23, 4375, 18, 3]}, "items": [{"id": "p_5191", "content": "Hyperprolactinemia [SEP] Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologi", "score": 1, "type": null, "tokenized_content": [2, 4194, 15743, 11686, 3847, 3, 2502, 2428, 1927, 18386, 1922, 1920, 2877, 16, 2154, 2278, 1998, 2458, 1956, 15969, 21588, 1930, 9479, 21588, 18, 4322, 3059, 8096, 2167, 1033, 3]}]}
{"query": {"id": "q_5192", "content": "pituitary tumors [SEP] with age (4% before age 50 years and 9% 50 years or older). Two pituitary tumors were discovered after testosterone determination. Most of the o", "tokenized_content": [2, 10621, 3861, 3, 1956, 2632, 12, 24, 9, 3119, 2632, 2761, 2739, 1930, 29, 9, 2761, 2739, 2014, 4706, 13, 18, 2288, 10621, 3861, 1985, 8117, 2256, 10592, 7063, 18, 3]}, "items": [{"id": "p_5192", "content": "Pituitary Neoplasms [SEP] Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are di", "score": 1, "type": null, "tokenized_content": [2, 10621, 15347, 3, 15347, 2154, 10149, 2037, 2014, 23257, 2606, 1942, 1920, 10621, 8359, 18, 1920, 4827, 1927, 10621, 15347, 2032, 16787, 16, 2154, 2032, 2137, 3]}]}
{"query": {"id": "q_5193", "content": "hypothalamic dysfunction [SEP]  other low testosterone levels seemed to result from nonorganic hypothalamic dysfunction because of normal serum luteinizing hormone and prolactin and t", "tokenized_content": [2, 13654, 5273, 3, 2303, 2330, 10592, 2428, 12292, 1942, 3211, 2037, 2447, 13606, 13654, 5273, 2882, 1927, 2791, 3256, 21600, 3903, 6365, 1930, 18386, 1930, 62, 3]}, "items": [{"id": "p_5193", "content": "Hypothalamic Diseases [SEP] Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders", "score": 1, "type": null, "tokenized_content": [2, 13654, 3902, 3, 12847, 16, 3769, 16, 7465, 16, 1930, 2303, 3902, 1927, 1920, 13708, 18, 2535, 10952, 3951, 17990, 4414, 3]}]}
{"query": {"id": "q_5194", "content": "prolactinoma [SEP] l. in 5 men and was normal in 2 at repeat determination. Only 1 prolactinoma was discovered. These data are lower than those we found during", "tokenized_content": [2, 18386, 2954, 3, 54, 18, 1922, 25, 3925, 1930, 1982, 2791, 1922, 22, 2019, 6865, 7063, 18, 2444, 21, 18386, 2954, 1982, 8117, 18, 2144, 2230, 2032, 2826, 2254, 2690, 3]}, "items": [{"id": "p_5194", "content": "Prolactinoma [SEP] A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTO", "score": 1, "type": null, "tokenized_content": [2, 18386, 2954, 3, 43, 10621, 16530, 2154, 15989, 1036, 18386, 16, 4523, 1942, 4194, 15743, 11686, 3847, 18, 2535, 10952, 3951, 15969, 21588, 31, 9479, 1037, 3]}]}
{"query": {"id": "q_5195", "content": "prolactinomas [SEP] l prolactin greater than 20 ng./ml. in 1.86% of 1,821 patients, prolactinomas in 7, 0.38%). Bromocriptine was definitely effective in cases w", "tokenized_content": [2, 18386, 4956, 3, 54, 18386, 3430, 2254, 2036, 4375, 18, 19, 2646, 18, 1922, 21, 18, 5713, 9, 1927, 21, 16, 6175, 1009, 2132, 16, 18386, 4956, 1922, 27, 16, 3]}, "items": [{"id": "p_5195", "content": "Prolactinoma [SEP] A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTO", "score": 1, "type": null, "tokenized_content": [2, 18386, 2954, 3, 43, 10621, 16530, 2154, 15989, 1036, 18386, 16, 4523, 1942, 4194, 15743, 11686, 3847, 18, 2535, 10952, 3951, 15969, 21588, 31, 9479, 1037, 3]}]}
{"query": {"id": "q_5196", "content": "Bromocriptine [SEP] ng./ml. in 1.86% of 1,821 patients, prolactinomas in 7, 0.38%). Bromocriptine was definitely effective in cases with prolactin greater than 3", "tokenized_content": [2, 21392, 4093, 2053, 3, 4375, 18, 19, 2646, 18, 1922, 21, 18, 5713, 9, 1927, 21, 16, 6175, 1009, 2132, 16, 18386, 4956, 1922, 27, 16, 20, 18, 3738, 9, 3]}, "items": [{"id": "p_5196", "content": "Bromocriptine [SEP] A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.\n    ", "score": 1, "type": null, "tokenized_content": [2, 21392, 4093, 2053, 3, 43, 8762, 18801, 4905, 4116, 2002, 11949, 7336, 25157, 29951, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 12987, 18386, 5512, 18, 3]}]}
{"query": {"id": "q_5197", "content": "Thiopentone [SEP] Thiopentone pretreatment for propofol injection pain in ambulatory patients", "tokenized_content": [2, 15331, 17125, 5405, 1021, 3, 15331, 17125, 5405, 1021, 9111, 1958, 16615, 4107, 3594, 1922, 15280, 2132, 3]}, "items": [{"id": "p_5197", "content": "Thiopental [SEP] A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anest", "score": 1, "type": null, "tokenized_content": [2, 15331, 17125, 2381, 3, 43, 30434, 4219, 5524, 2057, 1988, 1977, 5254, 15132, 1958, 1920, 4408, 1927, 3335, 8871, 2014, 1958, 1920, 3372, 1927, 4080, 9860, 2156, 3]}]}
{"query": {"id": "q_5198", "content": "propofol [SEP] Thiopentone pretreatment for propofol injection pain in ambulatory patients.", "tokenized_content": [2, 16615, 3, 15331, 17125, 5405, 1021, 9111, 1958, 16615, 4107, 3594, 1922, 15280, 2132, 18, 3]}, "items": [{"id": "p_5198", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_5199", "content": "pain [SEP] Thiopentone pretreatment for propofol injection pain in ambulatory patients.", "tokenized_content": [2, 3594, 3, 15331, 17125, 5405, 1021, 9111, 1958, 16615, 4107, 3594, 1922, 15280, 2132, 18, 3]}, "items": [{"id": "p_5199", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_5200", "content": "propofol [SEP] This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia. I", "tokenized_content": [2, 16615, 3, 2052, 2161, 3845, 16615, 4107, 3594, 1922, 2132, 7258, 15280, 17107, 18, 51, 3]}, "items": [{"id": "p_5200", "content": "Propofol [SEP] An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very shor", "score": 1, "type": null, "tokenized_content": [2, 16615, 3, 1925, 7307, 16111, 5899, 2154, 2258, 1920, 6607, 1927, 43, 3345, 4052, 4727, 2256, 7386, 2014, 14840, 4107, 5390, 43, 3345, 7203, 3]}]}
{"query": {"id": "q_5201", "content": "pain [SEP] This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia. In a randomized,", "tokenized_content": [2, 3594, 3, 2052, 2161, 3845, 16615, 4107, 3594, 1922, 2132, 7258, 15280, 17107, 18, 1922, 43, 5542, 16, 3]}, "items": [{"id": "p_5201", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_5202", "content": "lidocaine [SEP] Patients in Group C received 2 ml normal saline, Group L, 2 ml, lidocaine 2% (40 mg) and Group T, 2 ml thiopentone 2.5% (50 mg). Venous d", "tokenized_content": [2, 19567, 3, 2132, 1922, 2210, 45, 4004, 22, 2646, 2791, 5977, 16, 2210, 54, 16, 22, 2646, 16, 19567, 22, 9, 12, 3040, 2786, 13, 1930, 2210, 62, 16, 22, 3]}, "items": [{"id": "p_5202", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_5203", "content": "thiopentone [SEP] l saline, Group L, 2 ml, lidocaine 2% (40 mg) and Group T, 2 ml thiopentone 2.5% (50 mg). Venous discomfort was assessed with a visual anal", "tokenized_content": [2, 15331, 17125, 5405, 1021, 3, 54, 5977, 16, 2210, 54, 16, 22, 2646, 16, 19567, 22, 9, 12, 3040, 2786, 13, 1930, 2210, 62, 16, 22, 2646, 15331, 17125, 5405, 3]}, "items": [{"id": "p_5203", "content": "Thiopental [SEP] A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anest", "score": 1, "type": null, "tokenized_content": [2, 15331, 17125, 2381, 3, 43, 30434, 4219, 5524, 2057, 1988, 1977, 5254, 15132, 1958, 1920, 4408, 1927, 3335, 8871, 2014, 1958, 1920, 3372, 1927, 4080, 9860, 2156, 3]}]}
{"query": {"id": "q_5204", "content": "Loss of consciousness [SEP] ation using an infusion pump (rate 1000 micrograms.kg-1.min-1). Loss of consciousness occurred in 60-90 sec. Visual analogue scores (mean +/- SD) dur", "tokenized_content": [2, 3257, 1927, 16897, 3, 2019, 2001, 2193, 1925, 7386, 8912, 12, 2769, 5672, 13362, 18, 3621, 17, 21, 18, 2360, 17, 21, 13, 18, 3257, 1927, 16897, 4807, 1922, 3276, 3]}, "items": [{"id": "p_5204", "content": "Unconsciousness [SEP] Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental", "score": 1, "type": null, "tokenized_content": [2, 29267, 2971, 3, 3257, 1927, 1920, 3682, 1942, 6698, 8755, 1927, 3543, 1930, 3515, 4252, 1956, 7686, 3028, 10854, 1942, 4813, 3]}]}
{"query": {"id": "q_5205", "content": "glycopyrrolate [SEP] Comparison of i.v. glycopyrrolate and atropine in the prevention of bradycardia and arrhythmias f", "tokenized_content": [2, 8821, 3553, 2226, 2010, 3, 3723, 1927, 51, 18, 64, 18, 8821, 3553, 2226, 2010, 1930, 24031, 1922, 1920, 5455, 1927, 26192, 1930, 16934, 48, 3]}, "items": [{"id": "p_5205", "content": "Glycopyrrolate [SEP] A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with", "score": 1, "type": null, "tokenized_content": [2, 8821, 3553, 2226, 2010, 3, 43, 20318, 8151, 2251, 1966, 1925, 8059, 4302, 18538, 12486, 16, 1922, 2673, 4414, 1927, 1920, 8375, 6482, 16, 1930, 1942, 4412, 12999, 1929, 1956, 3]}]}
{"query": {"id": "q_5206", "content": "atropine [SEP] Comparison of i.v. glycopyrrolate and atropine in the prevention of bradycardia and arrhythmias following repe", "tokenized_content": [2, 24031, 3, 3723, 1927, 51, 18, 64, 18, 8821, 3553, 2226, 2010, 1930, 24031, 1922, 1920, 5455, 1927, 26192, 1930, 16934, 2894, 3699, 3]}, "items": [{"id": "p_5206", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_5207", "content": "bradycardia [SEP] arison of i.v. glycopyrrolate and atropine in the prevention of bradycardia and arrhythmias following repeated doses of suxamethonium in ch", "tokenized_content": [2, 26192, 3, 27950, 5810, 1927, 51, 18, 64, 18, 8821, 3553, 2226, 2010, 1930, 24031, 1922, 1920, 5455, 1927, 26192, 1930, 16934, 2894, 5116, 5312, 1927, 2020, 11414, 23568, 15414, 3]}, "items": [{"id": "p_5207", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_5208", "content": "arrhythmias [SEP] lycopyrrolate and atropine in the prevention of bradycardia and arrhythmias following repeated doses of suxamethonium in children.", "tokenized_content": [2, 16934, 3, 23158, 3553, 2226, 2010, 1930, 24031, 1922, 1920, 5455, 1927, 26192, 1930, 16934, 2894, 5116, 5312, 1927, 2020, 11414, 23568, 15414, 1922, 3069, 18, 3]}, "items": [{"id": "p_5208", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_5209", "content": "suxamethonium [SEP] tion of bradycardia and arrhythmias following repeated doses of suxamethonium in children.", "tokenized_content": [2, 2020, 11414, 23568, 15414, 3, 8685, 1916, 1927, 26192, 1930, 16934, 2894, 5116, 5312, 1927, 2020, 11414, 23568, 15414, 1922, 3069, 18, 3]}, "items": [{"id": "p_5209", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_5210", "content": "glycopyrrolate [SEP] The effectiveness of administration of glycopyrrolate 5 and 10 micrograms kg-1 and atropine 10 and 20 micrograms kg-1", "tokenized_content": [2, 8821, 3553, 2226, 2010, 3, 1920, 6001, 1927, 4183, 1927, 8821, 3553, 2226, 2010, 25, 1930, 2119, 13362, 3621, 17, 21, 1930, 24031, 2119, 1930, 2036, 13362, 3621, 17, 21, 3]}, "items": [{"id": "p_5210", "content": "Glycopyrrolate [SEP] A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with", "score": 1, "type": null, "tokenized_content": [2, 8821, 3553, 2226, 2010, 3, 43, 20318, 8151, 2251, 1966, 1925, 8059, 4302, 18538, 12486, 16, 1922, 2673, 4414, 1927, 1920, 8375, 6482, 16, 1930, 1942, 4412, 12999, 1929, 1956, 3]}]}
{"query": {"id": "q_5211", "content": "atropine [SEP] f administration of glycopyrrolate 5 and 10 micrograms kg-1 and atropine 10 and 20 micrograms kg-1 i.v. immediately before the induction", "tokenized_content": [2, 24031, 3, 48, 4183, 1927, 8821, 3553, 2226, 2010, 25, 1930, 2119, 13362, 3621, 17, 21, 1930, 24031, 2119, 1930, 2036, 13362, 3621, 17, 21, 51, 18, 64, 18, 6183, 3]}, "items": [{"id": "p_5211", "content": "Atropine [SEP] An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isome", "score": 1, "type": null, "tokenized_content": [2, 24031, 3, 1925, 29951, 16, 10398, 2037, 22834, 1019, 16610, 12595, 16443, 1019, 16, 2308, 2435, 1922, 2303, 4793, 16, 4994, 2638, 7241, 1972, 3336, 18, 4527, 21624, 9771, 25157, 1977, 1920, 23, 12, 61, 13, 17, 16239, 4911, 3870, 3]}]}
{"query": {"id": "q_5212", "content": "arrhythmia [SEP] .v. immediately before the induction of anaesthesia, to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in ch", "tokenized_content": [2, 18346, 3, 18, 64, 18, 6183, 3119, 1920, 4408, 1927, 17107, 16, 1942, 4625, 18346, 1930, 26192, 2894, 5116, 5312, 1927, 2020, 11414, 23568, 15414, 1922, 2016, 3]}, "items": [{"id": "p_5212", "content": "Arrhythmias, Cardiac [SEP] Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by", "score": 1, "type": null, "tokenized_content": [2, 16934, 16, 4435, 3, 2967, 12654, 1927, 1920, 2791, 20275, 24711, 1927, 1920, 4003, 2014, 6497, 8332, 18, 4435, 16934, 2112, 1998, 5947, 2007, 3]}]}
{"query": {"id": "q_5213", "content": "bradycardia [SEP]  before the induction of anaesthesia, to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children, was stud", "tokenized_content": [2, 26192, 3, 3119, 1920, 4408, 1927, 17107, 16, 1942, 4625, 18346, 1930, 26192, 2894, 5116, 5312, 1927, 2020, 11414, 23568, 15414, 1922, 3069, 16, 1982, 2060, 3]}, "items": [{"id": "p_5213", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_5214", "content": "suxamethonium [SEP]  prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children, was studied. A control group was included for comp", "tokenized_content": [2, 2020, 11414, 23568, 15414, 3, 4625, 18346, 1930, 26192, 2894, 5116, 5312, 1927, 2020, 11414, 23568, 15414, 1922, 3069, 16, 1982, 3942, 18, 43, 2285, 2210, 1982, 3063, 1958, 2059, 3]}, "items": [{"id": "p_5214", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_5215", "content": "Bradycardia [SEP] gnificantly different from the frequency with the active drugs. Bradycardia (defined as a decrease in heart rate to less than 50 beat min-1", "tokenized_content": [2, 26192, 3, 9005, 2077, 2031, 1954, 2413, 2037, 1920, 3528, 1956, 1920, 3500, 4195, 18, 26192, 12, 3608, 1966, 43, 3714, 1922, 4003, 2769, 1942, 2941, 2254, 2761, 17984, 2360, 3]}, "items": [{"id": "p_5215", "content": "Bradycardia [SEP] Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. Th", "score": 1, "type": null, "tokenized_content": [2, 26192, 3, 4435, 16934, 1988, 2032, 4378, 2007, 9122, 1954, 5470, 4003, 2769, 16, 5394, 4535, 2761, 19380, 2079, 8623, 1922, 2616, 4440, 18, 1913, 3]}]}
{"query": {"id": "q_5216", "content": "caffeine [SEP] Reduction in caffeine toxicity by acetaminophen.", "tokenized_content": [2, 14119, 3, 3378, 1922, 14119, 5532, 2007, 23311, 18, 3]}, "items": [{"id": "p_5216", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_5217", "content": "toxicity [SEP] Reduction in caffeine toxicity by acetaminophen.", "tokenized_content": [2, 5532, 3, 3378, 1922, 14119, 5532, 2007, 23311, 18, 3]}, "items": [{"id": "p_5217", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_5218", "content": "acetaminophen [SEP] Reduction in caffeine toxicity by acetaminophen.", "tokenized_content": [2, 23311, 3, 3378, 1922, 14119, 5532, 2007, 23311, 18, 3]}, "items": [{"id": "p_5218", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_5219", "content": "caffeine [SEP]  over-the-counter analgesic containing sodium acetylsalicylate, caffeine, and acetaminophen displayed no significant CNS stimulation des", "tokenized_content": [2, 14119, 3, 2338, 17, 1920, 17, 5836, 14501, 3165, 5227, 6894, 23880, 1935, 9075, 16, 14119, 16, 1930, 23311, 5822, 2239, 2228, 7520, 4177, 2270, 3]}, "items": [{"id": "p_5219", "content": "Caffeine [SEP] A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmac", "score": 1, "type": null, "tokenized_content": [2, 14119, 3, 43, 4963, 11414, 4905, 7969, 2912, 10414, 6966, 1922, 2673, 19860, 1930, 2222, 2251, 1966, 43, 7683, 5899, 18, 14119, 11, 61, 2501, 11892, 4602, 3]}]}
{"query": {"id": "q_5220", "content": "acetaminophen [SEP] ter analgesic containing sodium acetylsalicylate, caffeine, and acetaminophen displayed no significant CNS stimulation despite the presence o", "tokenized_content": [2, 23311, 3, 6005, 14501, 3165, 5227, 6894, 23880, 1935, 9075, 16, 14119, 16, 1930, 23311, 5822, 2239, 2228, 7520, 4177, 4281, 1920, 2990, 57, 3]}, "items": [{"id": "p_5220", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_5221", "content": "toxicity [SEP] he presence of acetaminophen (52 micrograms/mL) reduced the CNS toxicity of caffeine. Studies in DBA/2J mice showed that: 1) pretreatmen", "tokenized_content": [2, 5532, 3, 2234, 2990, 1927, 23311, 12, 4764, 13362, 19, 2646, 13, 3028, 1920, 7520, 5532, 1927, 14119, 18, 2351, 1922, 21854, 19, 24425, 2518, 2594, 1988, 30, 21, 13, 3]}, "items": [{"id": "p_5221", "content": "Drug-Related Side Effects and Adverse Reactions [SEP] Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chem", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2712, 4159, 2564, 1930, 5246, 5298, 3, 4414, 1988, 3211, 2037, 1920, 11214, 2485, 1927, 11106, 9815, 18, 3063, 1922, 2052, 26300, 2032, 43, 4949, 5386, 1927, 2975, 3]}]}
{"query": {"id": "q_5222", "content": "convulsions [SEP] ration of caffeine (300 to 450 mg/kg IP) and the onset of fatal convulsions by a factor of about two; and 2) pretreatment with acetaminophe", "tokenized_content": [2, 4772, 19389, 3, 12488, 1927, 14119, 12, 5255, 1942, 11193, 2786, 19, 3621, 5416, 13, 1930, 1920, 4727, 1927, 11990, 4772, 19389, 2007, 43, 2991, 1927, 3001, 2288, 31, 1930, 3]}, "items": [{"id": "p_5222", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5223", "content": "seizures [SEP] th acetaminophen (75 mg/kg) reduced the incidence of audiogenic seizures produced in the presence of caffeine (12.5 to 75 mg/kg IP). The", "tokenized_content": [2, 10060, 3, 1913, 23311, 12, 4089, 2786, 19, 3621, 13, 3028, 1920, 4332, 1927, 18609, 11216, 10060, 4152, 1922, 1920, 2990, 1927, 14119, 12, 2369, 18, 25, 1942, 4089, 2786, 3]}, "items": [{"id": "p_5223", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5224", "content": "pentylenetetrezol [SEP] y maximal electroshock and did not alter the convulsant dose of pentylenetetrezol in mice (tests performed by the Anticonvulsant Screening Projec", "tokenized_content": [2, 9412, 6752, 14278, 2588, 11788, 1945, 3, 67, 7275, 17975, 10647, 12940, 1930, 2811, 2084, 4238, 1920, 4772, 6325, 2031, 3253, 1927, 9412, 6752, 14278, 2588, 11788, 1945, 1922, 2518, 3]}, "items": [{"id": "p_5224", "content": "Pentylenetetrazole [SEP] A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-comp", "score": 1, "type": null, "tokenized_content": [2, 9412, 6752, 14278, 21193, 13642, 1952, 3, 43, 11106, 5899, 1988, 10750, 2455, 1966, 43, 4101, 7580, 2433, 1930, 5481, 24252, 18, 2176, 1977, 3311, 43, 2447, 17, 2059, 3]}]}
{"query": {"id": "q_5225", "content": "Acetaminophen [SEP] s performed by the Anticonvulsant Screening Project of NINCDS). Acetaminophen (up to 150 micrograms/mL) did not retard the incorporation of r", "tokenized_content": [2, 23311, 3, 61, 2593, 2007, 1920, 26572, 2031, 4449, 5539, 1927, 12117, 9547, 1036, 13, 18, 23311, 12, 2353, 1942, 5493, 13362, 19, 2646, 13, 2811, 2084, 14428, 1920, 8629, 3]}, "items": [{"id": "p_5225", "content": "Acetaminophen [SEP] Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but", "score": 1, "type": null, "tokenized_content": [2, 23311, 3, 14501, 2246, 18425, 3023, 10533, 1927, 4118, 16692, 2261, 18, 2176, 2258, 5015, 2246, 17, 3769, 3879, 1930, 1977, 2251, 1966, 43, 3059, 14501, 16, 2308, 3]}]}
{"query": {"id": "q_5226", "content": "adenosine [SEP]  micrograms/mL) did not retard the incorporation of radioactive adenosine into ATP in slices of rat cerebral cortex. Thus the mechanism b", "tokenized_content": [2, 10125, 3, 13362, 19, 2646, 13, 2811, 2084, 14428, 1920, 8629, 1927, 18237, 10125, 2460, 4498, 1922, 9002, 1927, 3067, 6329, 4997, 18, 2842, 1920, 2856, 44, 3]}, "items": [{"id": "p_5226", "content": "Adenosine [SEP] A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles i", "score": 1, "type": null, "tokenized_content": [2, 10125, 3, 43, 18015, 1988, 1977, 7179, 1927, 15643, 1930, 46, 17, 17870, 18, 10125, 2014, 10125, 8383, 3918, 3086, 2715, 3933, 5456, 51, 3]}]}
{"query": {"id": "q_5227", "content": "ATP [SEP]  did not retard the incorporation of radioactive adenosine into ATP in slices of rat cerebral cortex. Thus the mechanism by which a", "tokenized_content": [2, 4498, 3, 2811, 2084, 14428, 1920, 8629, 1927, 18237, 10125, 2460, 4498, 1922, 9002, 1927, 3067, 6329, 4997, 18, 2842, 1920, 2856, 2007, 2154, 43, 3]}, "items": [{"id": "p_5227", "content": "Adenosine Triphosphate [SEP] An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in meta", "score": 1, "type": null, "tokenized_content": [2, 10125, 17978, 3, 1925, 15643, 5489, 3165, 2559, 5413, 2671, 9603, 2828, 1942, 1920, 9523, 11804, 18, 1922, 2459, 1942, 2496, 6608, 5456, 1922, 5880, 3]}]}
{"query": {"id": "q_5228", "content": "Flestolol [SEP] Flestolol: an ultra-short-acting beta-adrenergic blocking agent.", "tokenized_content": [2, 17233, 2156, 23646, 3, 17233, 2156, 23646, 30, 1925, 12773, 17, 3662, 17, 8290, 4666, 17, 13672, 7472, 5899, 18, 3]}, "items": [{"id": "p_5228", "content": "flestolol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17233, 2156, 23646, 3, 3]}]}
{"query": {"id": "q_5229", "content": "Flestolol [SEP] Flestolol (ACC-9089) is a nonselective, competitive, ultra-short-acting b", "tokenized_content": [2, 17233, 2156, 23646, 3, 17233, 2156, 23646, 12, 2280, 17, 3865, 9485, 13, 1977, 43, 6771, 25568, 16, 10362, 16, 12773, 17, 3662, 17, 8290, 44, 3]}, "items": [{"id": "p_5229", "content": "flestolol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17233, 2156, 23646, 3, 3]}]}
{"query": {"id": "q_5230", "content": "ACC-9089 [SEP] Flestolol (ACC-9089) is a nonselective, competitive, ultra-short-acting beta-adrene", "tokenized_content": [2, 2280, 17, 3865, 9485, 3, 17233, 2156, 23646, 12, 2280, 17, 3865, 9485, 13, 1977, 43, 6771, 25568, 16, 10362, 16, 12773, 17, 3662, 17, 8290, 4666, 17, 7206, 1021, 3]}, "items": [{"id": "p_5230", "content": "flestolol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17233, 2156, 23646, 3, 3]}]}
{"query": {"id": "q_5231", "content": "flestolol [SEP] ses up to 100 micrograms/kg/min. In long-term infusion studies, flestolol was well tolerated at the effective beta-blocking dose (5 micro", "tokenized_content": [2, 17233, 2156, 23646, 3, 9924, 2353, 1942, 2813, 13362, 19, 3621, 19, 2360, 18, 1922, 2815, 17, 2576, 7386, 2351, 16, 17233, 2156, 23646, 1982, 2486, 11117, 2019, 1920, 3655, 3]}, "items": [{"id": "p_5231", "content": "flestolol [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 17233, 2156, 23646, 3, 3]}]}
{"query": {"id": "q_5232", "content": "isoproterenol [SEP] ic blockade. Flestolol produced a dose-dependent attenuation of isoproterenol-induced tachycardia. Electrophysiologic and hemodynamic effects", "tokenized_content": [2, 23743, 3, 3996, 9847, 18, 17233, 2156, 23646, 4152, 43, 3253, 17, 3100, 10961, 1927, 23743, 17, 2719, 17397, 18, 11350, 12649, 1930, 12173, 2564, 3]}, "items": [{"id": "p_5232", "content": "Isoproterenol [SEP] Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. I", "score": 1, "type": null, "tokenized_content": [2, 23743, 3, 20500, 5729, 1927, 19280, 31, 4666, 17, 26638, 1947, 21870, 1988, 8016, 1990, 1920, 4003, 16, 20431, 16, 7345, 3760, 16, 15356, 2017, 2141, 6482, 16, 8289, 18, 51, 3]}]}
{"query": {"id": "q_5233", "content": "tachycardia [SEP]  produced a dose-dependent attenuation of isoproterenol-induced tachycardia. Electrophysiologic and hemodynamic effects of flestolol are si", "tokenized_content": [2, 17397, 3, 4152, 43, 3253, 17, 3100, 10961, 1927, 23743, 17, 2719, 17397, 18, 11350, 12649, 1930, 12173, 2564, 1927, 17233, 2156, 23646, 2032, 5998, 3]}, "items": [{"id": "p_5233", "content": "Tachycardia [SEP] Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturba", "score": 1, "type": null, "tokenized_content": [2, 17397, 3, 20756, 4052, 4003, 5873, 1926, 16, 5394, 1956, 43, 4003, 2769, 3538, 2813, 19380, 2079, 8623, 1958, 4440, 18, 17397, 7936, 2007, 7863, 1019, 3]}]}
{"query": {"id": "q_5234", "content": "supraventricular tachyarrhythmia [SEP] life. Flestolol effectively reduced heart rate in patients with supraventricular tachyarrhythmia. In patients with unstable angina, flestolol infusion was found", "tokenized_content": [2, 21038, 24722, 12762, 9771, 18858, 10245, 6026, 3, 3308, 18, 17233, 2156, 23646, 7098, 3028, 4003, 2769, 1922, 2132, 1956, 21038, 24722, 12762, 9771, 18858, 10245, 6026, 18, 1922, 2132, 3]}, "items": [{"id": "p_5234", "content": "Tachycardia, Supraventricular [SEP] A generic expression for any tachycardia that originates above the BUNDLE OF HIS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17397, 16, 21038, 24722, 3, 43, 13459, 2294, 1958, 2967, 17397, 1988, 22970, 3538, 1920, 14142, 1927, 4167, 18, 3]}]}
{"query": {"id": "q_5235", "content": "unstable angina [SEP] atients with supraventricular tachyarrhythmia. In patients with unstable angina, flestolol infusion was found to be safe and effective in contr", "tokenized_content": [2, 11976, 16961, 3, 2019, 6746, 1956, 21038, 24722, 12762, 9771, 18858, 10245, 6026, 18, 1922, 2132, 1956, 11976, 16961, 16, 17233, 2156, 23646, 7386, 1982, 2435, 1942, 1998, 7672, 1930, 3]}, "items": [{"id": "p_5235", "content": "Angina, Unstable [SEP] Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.\n    ", "score": 1, "type": null, "tokenized_content": [2, 16961, 16, 11976, 3, 3648, 2538, 2086, 3594, 2019, 6172, 16, 2154, 2278, 25841, 43, 6497, 8358, 18, 3]}]}
{"query": {"id": "q_5236", "content": "chest pain [SEP] olol infusion was found to be safe and effective in controlling chest pain. It is concluded that flestolol is a potent, well-tolerated, ul", "tokenized_content": [2, 8475, 3594, 3, 2865, 1945, 7386, 1982, 2435, 1942, 1998, 7672, 1930, 3655, 1922, 7138, 8475, 3594, 18, 2176, 1977, 7903, 1988, 17233, 2156, 23646, 1977, 43, 6828, 16, 2486, 3]}, "items": [{"id": "p_5236", "content": "Chest Pain [SEP] Pressure, burning, or numbness in the chest.\n    ", "score": 1, "type": null, "tokenized_content": [2, 8475, 3594, 3, 3772, 16, 22873, 16, 2014, 25646, 2971, 1922, 1920, 8475, 18, 3]}]}
{"query": {"id": "q_5237", "content": "calcium [SEP] Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with re", "tokenized_content": [2, 5016, 3, 5246, 2495, 1927, 1920, 5016, 4999, 14580, 8214, 2200, 16027, 1990, 7737, 2263, 7571, 2475, 1922, 3615, 1956, 1964, 3]}, "items": [{"id": "p_5237", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_5238", "content": "nitrendipine [SEP] Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension.", "tokenized_content": [2, 8214, 2200, 16027, 3, 5246, 2495, 1927, 1920, 5016, 4999, 14580, 8214, 2200, 16027, 1990, 7737, 2263, 7571, 2475, 1922, 3615, 1956, 3866, 4901, 5579, 18, 3]}, "items": [{"id": "p_5238", "content": "Nitrendipine [SEP] A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calci", "score": 1, "type": null, "tokenized_content": [2, 8214, 2200, 16027, 3, 43, 5016, 4999, 14580, 1956, 4961, 28194, 4615, 18, 2176, 1977, 1925, 3655, 16439, 5899, 1930, 11457, 2037, 2303, 2799, 1033, 3]}]}
{"query": {"id": "q_5239", "content": "nephrosclerosis [SEP] Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension.", "tokenized_content": [2, 7737, 2263, 7571, 2475, 3, 5246, 2495, 1927, 1920, 5016, 4999, 14580, 8214, 2200, 16027, 1990, 7737, 2263, 7571, 2475, 1922, 3615, 1956, 3866, 4901, 5579, 18, 3]}, "items": [{"id": "p_5239", "content": "Nephrosclerosis [SEP] Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or ", "score": 1, "type": null, "tokenized_content": [2, 7737, 2263, 7571, 2475, 3, 6986, 3291, 1927, 1920, 5245, 2810, 1942, 8946, 2007, 15711, 14948, 2960, 12, 6769, 13, 16, 5394, 4189, 2007, 3866, 4901, 3902, 2014, 3]}]}
{"query": {"id": "q_5240", "content": "renovascular hypertension [SEP] um channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension.", "tokenized_content": [2, 3866, 4901, 5579, 3, 8736, 4999, 14580, 8214, 2200, 16027, 1990, 7737, 2263, 7571, 2475, 1922, 3615, 1956, 3866, 4901, 5579, 18, 3]}, "items": [{"id": "p_5240", "content": "Hypertension, Renovascular [SEP] Hypertension due to RENAL ARTERY OBSTRUCTION or compression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 3866, 4901, 3, 5579, 2810, 1942, 4604, 5511, 10849, 2014, 10399, 18, 3]}]}
{"query": {"id": "q_5241", "content": "calcium [SEP] The effect of a 6-week treatment with the calcium channel blocker nitrendipine or the angiotensin converting enzy", "tokenized_content": [2, 5016, 3, 1920, 2495, 1927, 43, 26, 17, 2982, 2311, 1956, 1920, 5016, 4999, 14580, 8214, 2200, 16027, 2014, 1920, 10814, 15025, 27862, 1012, 3]}, "items": [{"id": "p_5241", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_5242", "content": "nitrendipine [SEP] e effect of a 6-week treatment with the calcium channel blocker nitrendipine or the angiotensin converting enzyme inhibitor enalapril on blo", "tokenized_content": [2, 8214, 2200, 16027, 3, 47, 2495, 1927, 43, 26, 17, 2982, 2311, 1956, 1920, 5016, 4999, 14580, 8214, 2200, 16027, 2014, 1920, 10814, 15025, 4113, 4106, 2066, 8056, 2047, 1970, 3]}, "items": [{"id": "p_5242", "content": "Nitrendipine [SEP] A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calci", "score": 1, "type": null, "tokenized_content": [2, 8214, 2200, 16027, 3, 43, 5016, 4999, 14580, 1956, 4961, 28194, 4615, 18, 2176, 1977, 1925, 3655, 16439, 5899, 1930, 11457, 2037, 2303, 2799, 1033, 3]}]}
{"query": {"id": "q_5243", "content": "angiotensin [SEP]  treatment with the calcium channel blocker nitrendipine or the angiotensin converting enzyme inhibitor enalapril on blood pressure, albumi", "tokenized_content": [2, 10814, 3, 2311, 1956, 1920, 5016, 4999, 14580, 8214, 2200, 16027, 2014, 1920, 10814, 15025, 4113, 4106, 2066, 8056, 2047, 1970, 1990, 2877, 3772, 16, 5311, 28851, 3]}, "items": [{"id": "p_5243", "content": "Angiotensins [SEP] Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANG", "score": 1, "type": null, "tokenized_content": [2, 10814, 1036, 3, 15039, 9626, 2410, 3726, 2154, 2032, 2715, 1922, 1920, 3640, 1927, 2877, 3772, 12, 21843, 13, 1930, 5466, 7622, 3454, 1920, 16306, 17, 3409, 3]}]}
{"query": {"id": "q_5244", "content": "enalapril [SEP] ker nitrendipine or the angiotensin converting enzyme inhibitor enalapril on blood pressure, albuminuria, renal hemodynamics, and morphol", "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 6712, 8214, 2200, 16027, 2014, 1920, 10814, 15025, 4113, 4106, 2066, 8056, 2047, 1970, 1990, 2877, 3772, 16, 24962, 16, 4604, 22482, 16, 1930, 3901, 3]}, "items": [{"id": "p_5244", "content": "Enalapril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 1988, 1977, 2251, 1942, 2297, 5579, 18, 3]}]}
{"query": {"id": "q_5245", "content": "albuminuria [SEP] tensin converting enzyme inhibitor enalapril on blood pressure, albuminuria, renal hemodynamics, and morphology of the nonclipped kidney wa", "tokenized_content": [2, 24962, 3, 10202, 1921, 15025, 4113, 4106, 2066, 8056, 2047, 1970, 1990, 2877, 3772, 16, 24962, 16, 4604, 22482, 16, 1930, 6076, 1927, 1920, 9341, 8257, 7438, 5245, 4114, 3]}, "items": [{"id": "p_5245", "content": "Albuminuria [SEP] The presence of albumin in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24962, 3, 1920, 2990, 1927, 7712, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_5246", "content": "renovascular hypertension [SEP] nonclipped kidney was studied in rats with two-kidney, one clip renovascular hypertension. Six weeks after clipping of one renal artery, hypertensive rat", "tokenized_content": [2, 3866, 4901, 5579, 3, 9341, 8257, 7438, 5245, 1982, 3942, 1922, 3615, 1956, 2288, 17, 5245, 16, 2340, 18709, 3866, 4901, 5579, 18, 3798, 3625, 2256, 18709, 9219, 1927, 2340, 3]}, "items": [{"id": "p_5246", "content": "Hypertension, Renovascular [SEP] Hypertension due to RENAL ARTERY OBSTRUCTION or compression.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5579, 16, 3866, 4901, 3, 5579, 2810, 1942, 4604, 5511, 10849, 2014, 10399, 18, 3]}]}
{"query": {"id": "q_5247", "content": "hypertensive [SEP] lar hypertension. Six weeks after clipping of one renal artery, hypertensive rats (178 +/- 4 mm Hg) were randomly assigned to three groups: ", "tokenized_content": [2, 11706, 3, 6590, 5579, 18, 3798, 3625, 2256, 18709, 9219, 1927, 2340, 4604, 5511, 16, 11706, 3615, 12, 16877, 15, 19, 17, 24, 2489, 7175, 13, 1985, 6266, 6304, 1942, 3]}, "items": [{"id": "p_5247", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5248", "content": "Enalapril [SEP] as obtained for determination of glomerular size and sclerosis. Enalapril but not nitrendipine reduced blood pressure significantly. Afte", "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 1966, 2926, 1958, 7063, 1927, 11655, 3081, 1930, 11484, 18, 2066, 8056, 2047, 1970, 2308, 2084, 8214, 2200, 16027, 3028, 2877, 3772, 2567, 18, 2221, 3]}, "items": [{"id": "p_5248", "content": "Enalapril [SEP] One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2066, 8056, 2047, 1970, 3, 2340, 1927, 1920, 10814, 17, 15025, 4113, 4472, 1988, 1977, 2251, 1942, 2297, 5579, 18, 3]}]}
{"query": {"id": "q_5249", "content": "glomerulosclerosis [SEP]  groups. Renal plasma flow increased, but albumin excretion and glomerulosclerosis did not change after enalapril treatment. In contrast, in the n", "tokenized_content": [2, 19268, 25081, 3, 2671, 18, 4604, 3582, 3426, 2502, 16, 2308, 7712, 11093, 1930, 19268, 25081, 2811, 2084, 3185, 2256, 2066, 8056, 2047, 1970, 2311, 18, 1922, 3320, 16, 1922, 3]}, "items": [{"id": "p_5249", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_5250", "content": "tinnitus [SEP] Treatment of tinnitus by intratympanic instillation of lignocaine (lidocaine) 2 per c", "tokenized_content": [2, 19176, 3, 2311, 1927, 19176, 2007, 5153, 3145, 6588, 19510, 24893, 1927, 12975, 17678, 12, 19567, 13, 22, 2079, 45, 3]}, "items": [{"id": "p_5250", "content": "Tinnitus [SEP] A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other no", "score": 1, "type": null, "tokenized_content": [2, 19176, 3, 43, 12720, 3226, 1927, 8512, 4770, 4378, 2007, 1920, 15826, 1927, 3168, 18559, 1941, 16, 6335, 1941, 16, 15127, 1941, 16, 8109, 2082, 16, 1930, 2303, 2239, 3]}]}
{"query": {"id": "q_5251", "content": "lignocaine [SEP] Treatment of tinnitus by intratympanic instillation of lignocaine (lidocaine) 2 per cent through ventilation tubes.", "tokenized_content": [2, 12975, 17678, 3, 2311, 1927, 19176, 2007, 5153, 3145, 6588, 19510, 24893, 1927, 12975, 17678, 12, 19567, 13, 22, 2079, 3208, 2596, 10198, 9403, 18, 3]}, "items": [{"id": "p_5251", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_5252", "content": "lidocaine [SEP] atment of tinnitus by intratympanic instillation of lignocaine (lidocaine) 2 per cent through ventilation tubes.", "tokenized_content": [2, 19567, 3, 7513, 1939, 1927, 19176, 2007, 5153, 3145, 6588, 19510, 24893, 1927, 12975, 17678, 12, 19567, 13, 22, 2079, 3208, 2596, 10198, 9403, 18, 3]}, "items": [{"id": "p_5252", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_5253", "content": "Idiopathic subjective tinnitus [SEP] Idiopathic subjective tinnitus (IST) is one of the most obscure otological pathologies. This p", "tokenized_content": [2, 13513, 9106, 19176, 3, 13513, 9106, 19176, 12, 1977, 1031, 13, 1977, 2340, 1927, 1920, 2501, 24245, 7608, 2477, 14407, 18, 2052, 58, 3]}, "items": [{"id": "p_5253", "content": "Tinnitus [SEP] A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other no", "score": 1, "type": null, "tokenized_content": [2, 19176, 3, 43, 12720, 3226, 1927, 8512, 4770, 4378, 2007, 1920, 15826, 1927, 3168, 18559, 1941, 16, 6335, 1941, 16, 15127, 1941, 16, 8109, 2082, 16, 1930, 2303, 2239, 3]}]}
{"query": {"id": "q_5254", "content": "IST [SEP] Idiopathic subjective tinnitus (IST) is one of the most obscure otological pathologies. This paper ", "tokenized_content": [2, 1977, 1031, 3, 13513, 9106, 19176, 12, 1977, 1031, 13, 1977, 2340, 1927, 1920, 2501, 24245, 7608, 2477, 14407, 18, 2052, 4648, 3]}, "items": [{"id": "p_5254", "content": "Tinnitus [SEP] A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other no", "score": 1, "type": null, "tokenized_content": [2, 19176, 3, 43, 12720, 3226, 1927, 8512, 4770, 4378, 2007, 1920, 15826, 1927, 3168, 18559, 1941, 16, 6335, 1941, 16, 15127, 1941, 16, 8109, 2082, 16, 1930, 2303, 2239, 3]}]}
{"query": {"id": "q_5255", "content": "lignocaine [SEP] ts the results of treating IST by intratympanic instillation of lignocaine (lidocaine) 2 per cent through a grommet, for five weekly cours", "tokenized_content": [2, 12975, 17678, 3, 4894, 1920, 2274, 1927, 8247, 1977, 1031, 2007, 5153, 3145, 6588, 19510, 24893, 1927, 12975, 17678, 12, 19567, 13, 22, 2079, 3208, 2596, 43, 8947, 7445, 1946, 3]}, "items": [{"id": "p_5255", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_5256", "content": "lidocaine [SEP] ts of treating IST by intratympanic instillation of lignocaine (lidocaine) 2 per cent through a grommet, for five weekly courses. Fifty-t", "tokenized_content": [2, 19567, 3, 4894, 1927, 8247, 1977, 1031, 2007, 5153, 3145, 6588, 19510, 24893, 1927, 12975, 17678, 12, 19567, 13, 22, 2079, 3208, 2596, 43, 8947, 7445, 1946, 16, 1958, 3628, 3]}, "items": [{"id": "p_5256", "content": "Lidocaine [SEP] A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more pro", "score": 1, "type": null, "tokenized_content": [2, 19567, 3, 43, 3076, 16111, 1930, 4435, 20852, 2031, 2251, 1966, 1925, 2246, 23246, 6026, 5899, 18, 2496, 7728, 2032, 2253, 10702, 1930, 2496, 2564, 2253, 1965, 3]}]}
{"query": {"id": "q_5257", "content": "tinnitus [SEP] Idiopathic subjective tinnitus (IST) is one of the most obscure otological pathologies. This p", "tokenized_content": [2, 19176, 3, 13513, 9106, 19176, 12, 1977, 1031, 13, 1977, 2340, 1927, 1920, 2501, 24245, 7608, 2477, 14407, 18, 2052, 58, 3]}, "items": [{"id": "p_5257", "content": "Tinnitus [SEP] A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other no", "score": 1, "type": null, "tokenized_content": [2, 19176, 3, 43, 12720, 3226, 1927, 8512, 4770, 4378, 2007, 1920, 15826, 1927, 3168, 18559, 1941, 16, 6335, 1941, 16, 15127, 1941, 16, 8109, 2082, 16, 1930, 2303, 2239, 3]}]}
{"query": {"id": "q_5258", "content": "vertigo [SEP] ng results. Patients should be warned about the side effects of vertigo and vomiting, which subsides gradually with every new instillat", "tokenized_content": [2, 3566, 28870, 3, 4375, 2274, 18, 2132, 3066, 1998, 8200, 5300, 3001, 1920, 4159, 2564, 1927, 3566, 28870, 1930, 13954, 16, 2154, 23981, 1918, 9690, 1956, 4808, 2814, 4766, 10888, 3]}, "items": [{"id": "p_5258", "content": "Vertigo [SEP] An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. V", "score": 1, "type": null, "tokenized_content": [2, 3566, 28870, 3, 1925, 3652, 2670, 1927, 5829, 16, 3108, 1927, 1920, 5771, 4867, 5197, 11527, 4760, 1920, 2725, 2014, 1927, 1920, 2725, 5197, 11527, 1922, 5230, 18, 64, 3]}]}
{"query": {"id": "q_5259", "content": "vomiting [SEP] Patients should be warned about the side effects of vertigo and vomiting, which subsides gradually with every new instillation, and that", "tokenized_content": [2, 13954, 3, 2132, 3066, 1998, 8200, 5300, 3001, 1920, 4159, 2564, 1927, 3566, 28870, 1930, 13954, 16, 2154, 23981, 1918, 9690, 1956, 4808, 2814, 24893, 16, 1930, 1988, 3]}, "items": [{"id": "p_5259", "content": "Vomiting [SEP] The forcible expulsion of the contents of the STOMACH through the MOUTH.\n    ", "score": 1, "type": null, "tokenized_content": [2, 13954, 3, 1920, 1958, 3349, 7272, 2887, 12138, 1927, 1920, 8906, 1927, 1920, 11399, 2596, 1920, 11701, 18, 3]}]}
{"query": {"id": "q_5260", "content": "Perhexiline maleate [SEP] Perhexiline maleate and peripheral neuropathy.", "tokenized_content": [2, 7990, 2783, 19204, 4005, 2010, 3, 7990, 2783, 19204, 4005, 2010, 1930, 5009, 13177, 18, 3]}, "items": [{"id": "p_5260", "content": "perhexiline maleate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7990, 2783, 19204, 4005, 2010, 3, 3]}]}
{"query": {"id": "q_5261", "content": "peripheral neuropathy [SEP] Perhexiline maleate and peripheral neuropathy.", "tokenized_content": [2, 5009, 13177, 3, 7990, 2783, 19204, 4005, 2010, 1930, 5009, 13177, 18, 3]}, "items": [{"id": "p_5261", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_5262", "content": "Peripheral neuropathy [SEP] Peripheral neuropathy has been noted as a complication of therapy with perhexiline ma", "tokenized_content": [2, 5009, 13177, 3, 5009, 13177, 2258, 2252, 5040, 1966, 43, 9388, 1927, 3181, 1956, 7990, 2783, 19204, 2488, 3]}, "items": [{"id": "p_5262", "content": "Peripheral Nervous System Diseases [SEP] Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, pl", "score": 1, "type": null, "tokenized_content": [2, 5009, 7580, 2433, 3902, 3, 3902, 1927, 1920, 5009, 12014, 5771, 1942, 1920, 3068, 1930, 6071, 6670, 16, 2154, 5921, 3902, 1927, 1920, 5507, 9398, 16, 13086, 16, 2123, 3]}]}
{"query": {"id": "q_5263", "content": "perhexiline maleate [SEP] ral neuropathy has been noted as a complication of therapy with perhexiline maleate, a drug widely used in France (and in clinical trials in the Un", "tokenized_content": [2, 7990, 2783, 19204, 4005, 2010, 3, 15906, 13177, 2258, 2252, 5040, 1966, 43, 9388, 1927, 3181, 1956, 7990, 2783, 19204, 4005, 2010, 16, 43, 2838, 5673, 2251, 1922, 10707, 12, 3]}, "items": [{"id": "p_5263", "content": "perhexiline maleate [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 7990, 2783, 19204, 4005, 2010, 3, 3]}]}
{"query": {"id": "q_5264", "content": "angina pectoris [SEP]  trials in the United States) for the prophylactic treatment of angina pectoris. In 24 patients with this complication, the marked slowing of m", "tokenized_content": [2, 16961, 23540, 1937, 3, 3848, 1922, 1920, 6128, 4376, 13, 1958, 1920, 14847, 2311, 1927, 16961, 23540, 1937, 18, 1922, 2686, 2132, 1956, 2052, 9388, 16, 1920, 4961, 20025, 1927, 3]}, "items": [{"id": "p_5264", "content": "Angina Pectoris [SEP] The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is", "score": 1, "type": null, "tokenized_content": [2, 16961, 23540, 1937, 3, 1920, 3226, 1927, 28033, 3594, 16693, 1942, 6497, 7716, 5394, 1927, 15308, 2728, 16, 5185, 1930, 5442, 18, 2176, 1977, 3]}]}
{"query": {"id": "q_5265", "content": "demyelinating disorder [SEP] ction velocity and the electromyographic changes imply mainly a demyelinating disorder. Improvement was noted with cessation of therapy. In a few case", "tokenized_content": [2, 29340, 4770, 3, 3369, 2001, 7227, 1930, 1920, 22755, 4158, 2840, 12477, 4994, 43, 29340, 4770, 18, 4990, 1982, 5040, 1956, 10975, 1927, 3181, 18, 1922, 43, 3855, 3087, 3]}, "items": [{"id": "p_5265", "content": "Demyelinating Diseases [SEP] Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.\n    ", "score": 1, "type": null, "tokenized_content": [2, 29340, 3902, 3, 3902, 4378, 2007, 3257, 2014, 5273, 1927, 12996, 1922, 1920, 4101, 2014, 5009, 7580, 2433, 18, 3]}]}
{"query": {"id": "q_5266", "content": "neuropathy [SEP] Peripheral neuropathy has been noted as a complication of therapy with perhexiline ma", "tokenized_content": [2, 13177, 3, 5009, 13177, 2258, 2252, 5040, 1966, 43, 9388, 1927, 3181, 1956, 7990, 2783, 19204, 2488, 3]}, "items": [{"id": "p_5266", "content": "Nervous System Diseases [SEP] Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, periph", "score": 1, "type": null, "tokenized_content": [2, 7580, 2433, 3902, 3, 3902, 1927, 1920, 4101, 1930, 5009, 7580, 2433, 18, 2052, 5921, 4414, 1927, 1920, 3068, 16, 6071, 6670, 16, 13598, 12014, 16, 4610, 1023, 3]}]}
{"query": {"id": "q_5267", "content": "morphine [SEP] Effect of humoral modulators of morphine-induced increase in locomotor activity of mice.", "tokenized_content": [2, 11553, 3, 2495, 1927, 16601, 17455, 1927, 11553, 17, 2719, 2760, 1922, 13594, 2455, 1927, 2518, 18, 3]}, "items": [{"id": "p_5267", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_5268", "content": "increase in locomotor activity [SEP] Effect of humoral modulators of morphine-induced increase in locomotor activity of mice.", "tokenized_content": [2, 2760, 1922, 13594, 2455, 3, 2495, 1927, 16601, 17455, 1927, 11553, 17, 2719, 2760, 1922, 13594, 2455, 1927, 2518, 18, 3]}, "items": [{"id": "p_5268", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_5269", "content": "morphine [SEP] The effect of humoral modulators on the morphine-induced increase in locomotor activity of mice was studied. The", "tokenized_content": [2, 11553, 3, 1920, 2495, 1927, 16601, 17455, 1990, 1920, 11553, 17, 2719, 2760, 1922, 13594, 2455, 1927, 2518, 1982, 3942, 18, 1920, 3]}, "items": [{"id": "p_5269", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_5270", "content": "increase in locomotor activity [SEP] The effect of humoral modulators on the morphine-induced increase in locomotor activity of mice was studied. The subcutaneous administration of 10 mg/k", "tokenized_content": [2, 2760, 1922, 13594, 2455, 3, 1920, 2495, 1927, 16601, 17455, 1990, 1920, 11553, 17, 2719, 2760, 1922, 13594, 2455, 1927, 2518, 1982, 3942, 18, 1920, 8634, 4183, 1927, 2119, 2786, 3]}, "items": [{"id": "p_5270", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_5271", "content": "hyperactivity [SEP] ed increase in locomotor activity in mice. The morphine-induced hyperactivity was potentiated by scopolamine and attenuated by physostigmine.", "tokenized_content": [2, 15534, 3, 3347, 2760, 1922, 13594, 2455, 1922, 2518, 18, 1920, 11553, 17, 2719, 15534, 1982, 20419, 2007, 25392, 10173, 25157, 1930, 8060, 2007, 2861, 2259, 29043, 2053, 18, 3]}, "items": [{"id": "p_5271", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_5272", "content": "scopolamine [SEP]  in mice. The morphine-induced hyperactivity was potentiated by scopolamine and attenuated by physostigmine. In contrast, both methscopolam", "tokenized_content": [2, 25392, 10173, 25157, 3, 1922, 2518, 18, 1920, 11553, 17, 2719, 15534, 1982, 20419, 2007, 25392, 10173, 25157, 1930, 8060, 2007, 2861, 2259, 29043, 2053, 18, 1922, 3320, 16, 2321, 3]}, "items": [{"id": "p_5272", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_5273", "content": "physostigmine [SEP]  hyperactivity was potentiated by scopolamine and attenuated by physostigmine. In contrast, both methscopolamine and neostigmine, which do no", "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 15534, 1982, 20419, 2007, 25392, 10173, 25157, 1930, 8060, 2007, 2861, 2259, 29043, 2053, 18, 1922, 3320, 16, 2321, 2295, 12709, 9986, 3812, 1930, 11724, 3]}, "items": [{"id": "p_5273", "content": "Physostigmine [SEP] A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also c", "score": 1, "type": null, "tokenized_content": [2, 2861, 2259, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 1988, 1977, 6221, 14504, 2596, 5726, 18, 2176, 2112, 1998, 3730, 12259, 1954, 1942, 1920, 16911, 1019, 18, 2176, 2222, 45, 3]}]}
{"query": {"id": "q_5274", "content": "methscopolamine [SEP]  scopolamine and attenuated by physostigmine. In contrast, both methscopolamine and neostigmine, which do not penetrate the blood-brain barrier", "tokenized_content": [2, 2295, 12709, 9986, 3812, 3, 25392, 10173, 25157, 1930, 8060, 2007, 2861, 2259, 29043, 2053, 18, 1922, 3320, 16, 2321, 2295, 12709, 9986, 3812, 1930, 11724, 2156, 29043, 2053, 16, 3]}, "items": [{"id": "p_5274", "content": "N-Methylscopolamine [SEP] A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 12709, 9986, 3812, 3, 43, 20318, 8151, 2251, 1942, 2161, 2743, 3779, 1927, 20318, 13908, 4086, 18, 3]}]}
{"query": {"id": "q_5275", "content": "neostigmine [SEP] enuated by physostigmine. In contrast, both methscopolamine and neostigmine, which do not penetrate the blood-brain barrier, had no effect ", "tokenized_content": [2, 11724, 2156, 29043, 2053, 3, 2066, 20312, 2007, 2861, 2259, 29043, 2053, 18, 1922, 3320, 16, 2321, 2295, 12709, 9986, 3812, 1930, 11724, 2156, 29043, 2053, 16, 2154, 2608, 2084, 3]}, "items": [{"id": "p_5275", "content": "Neostigmine [SEP] A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gal", "score": 1, "type": null, "tokenized_content": [2, 11724, 2156, 29043, 2053, 3, 43, 15440, 2156, 7124, 4127, 4106, 2251, 1922, 1920, 2311, 1927, 3057, 27618, 8572, 12413, 1937, 1930, 1942, 5267, 1920, 2564, 1927, 3760, 7327, 2356, 2427, 1966, 5179, 3]}]}
{"query": {"id": "q_5276", "content": "alpha-methyltyrosine [SEP] e hyperactivity produced by morphine. Pretreatment of mice with alpha-methyltyrosine (20 mg/kg i.p., one hour), an inhibitor of tyrosine hydroxylase", "tokenized_content": [2, 4595, 17, 4963, 3145, 20580, 3, 47, 15534, 4152, 2007, 11553, 18, 9111, 1927, 2518, 1956, 4595, 17, 4963, 3145, 20580, 12, 2036, 2786, 19, 3621, 51, 18, 58, 18, 3]}, "items": [{"id": "p_5276", "content": "alpha-Methyltyrosine [SEP] An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control ", "score": 1, "type": null, "tokenized_content": [2, 4595, 17, 4963, 3145, 20580, 3, 1925, 4106, 1927, 1920, 4113, 6941, 23, 17, 8914, 13966, 16, 1930, 7099, 1927, 1920, 4271, 1927, 25923, 18, 2176, 1977, 2251, 1942, 2285, 3]}]}
{"query": {"id": "q_5277", "content": "tyrosine [SEP] ity produced by morphine. Pretreatment of mice with alpha-methyltyrosine (20 mg/kg i.p., one hour), an inhibitor of tyrosine hydroxylase", "tokenized_content": [2, 6941, 3, 2176, 1012, 4152, 2007, 11553, 18, 9111, 1927, 2518, 1956, 4595, 17, 4963, 3145, 20580, 12, 2036, 2786, 19, 3621, 51, 18, 58, 18, 16, 2340, 6231, 13, 3]}, "items": [{"id": "p_5277", "content": "Tyrosine [SEP] A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HO", "score": 1, "type": null, "tokenized_content": [2, 6941, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 1922, 3555, 2176, 1977, 6653, 2037, 17388, 18, 2176, 1977, 2222, 1920, 7897, 1927, 19280, 31, 6918, 6673, 3]}]}
{"query": {"id": "q_5278", "content": "p-chlorophenylalamine [SEP] asing effects of morphine. On the other hand, pretreatment with p-chlorophenylalamine (3 X 320 mg/kg i.p., 24 hr), a serotonin depletor, caused no si", "tokenized_content": [2, 58, 17, 10107, 17616, 2199, 7010, 2053, 3, 25872, 2029, 2564, 1927, 11553, 18, 1990, 1920, 2303, 3897, 16, 9111, 1956, 58, 17, 10107, 17616, 2199, 7010, 2053, 12, 23, 3]}, "items": [{"id": "p_5278", "content": "Fenclonine [SEP] A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYD", "score": 1, "type": null, "tokenized_content": [2, 15096, 2223, 12530, 3, 43, 5328, 1930, 14104, 4106, 1927, 13489, 16324, 16, 43, 2769, 17, 8051, 4113, 1922, 1920, 8132, 1927, 11153, 12, 25, 17, 2993, 3]}]}
{"query": {"id": "q_5279", "content": "serotonin [SEP] tment with p-chlorophenylalamine (3 X 320 mg/kg i.p., 24 hr), a serotonin depletor, caused no significant change in the hyperactivity. Th", "tokenized_content": [2, 11153, 3, 22377, 4905, 1956, 58, 17, 10107, 17616, 2199, 7010, 2053, 12, 23, 66, 15476, 2786, 19, 3621, 51, 18, 58, 18, 16, 2686, 3668, 13, 16, 43, 11153, 3]}, "items": [{"id": "p_5279", "content": "Serotonin [SEP] A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily i", "score": 1, "type": null, "tokenized_content": [2, 11153, 3, 43, 6503, 16716, 1930, 7888, 16, 6653, 2037, 1920, 4415, 3835, 2687, 54, 17, 13489, 18, 1922, 5209, 2176, 1977, 2435, 5985, 51, 3]}]}
{"query": {"id": "q_5280", "content": "catecholamines [SEP] y-increasing effects of morphine are mediated by the release of catecholamines from adrenergic neurons in the brain. And the results are consi", "tokenized_content": [2, 25923, 3, 67, 17, 3605, 2564, 1927, 11553, 2032, 3434, 2007, 1920, 4012, 1927, 25923, 2037, 13672, 3558, 1922, 1920, 3068, 18, 1930, 1920, 2274, 2032, 2134, 1033, 3]}, "items": [{"id": "p_5280", "content": "Catecholamines [SEP] A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.\n    ", "score": 1, "type": null, "tokenized_content": [2, 25923, 3, 43, 3335, 2921, 1927, 24343, 17, 20684, 17616, 2199, 5135, 2199, 14286, 3595, 2037, 6941, 18, 3]}]}
{"query": {"id": "q_5281", "content": "acetylcholine [SEP] h the hypothesis that morphine acts by retarding the release of acetylcholine at some central cholinergic synapses. It is also suggested from", "tokenized_content": [2, 14561, 3, 50, 1920, 4676, 1988, 11553, 8016, 2007, 14428, 1941, 1920, 4012, 1927, 14561, 2019, 2673, 4101, 13908, 10373, 18, 2176, 1977, 2222, 3978, 2037, 3]}, "items": [{"id": "p_5281", "content": "Acetylcholine [SEP] A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathe", "score": 1, "type": null, "tokenized_content": [2, 14561, 3, 43, 15223, 2435, 2019, 15829, 11245, 16, 13725, 13086, 16, 23984, 7917, 11245, 16, 43, 6728, 1927, 26638, 1021, 3]}]}
{"query": {"id": "q_5282", "content": "FK 506 [SEP] Mechanisms of FK 506-induced hypertension in the rat.", "tokenized_content": [2, 13134, 29202, 3, 3531, 1927, 13134, 29202, 17, 2719, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_5282", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_5283", "content": "hypertension [SEP] Mechanisms of FK 506-induced hypertension in the rat.", "tokenized_content": [2, 5579, 3, 3531, 1927, 13134, 29202, 17, 2719, 5579, 1922, 1920, 3067, 18, 3]}, "items": [{"id": "p_5283", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5284", "content": "Tacrolimus [SEP] -Tacrolimus (FK 506) is a powerful, widely used immunosuppressant. The clin", "tokenized_content": [2, 21801, 3, 17, 21801, 12, 13134, 29202, 13, 1977, 43, 9974, 16, 5673, 2251, 27996, 2031, 18, 1920, 2442, 3]}, "items": [{"id": "p_5284", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_5285", "content": "FK 506 [SEP] -Tacrolimus (FK 506) is a powerful, widely used immunosuppressant. The clinical uti", "tokenized_content": [2, 13134, 29202, 3, 17, 21801, 12, 13134, 29202, 13, 1977, 43, 9974, 16, 5673, 2251, 27996, 2031, 18, 1920, 2535, 21472, 3]}, "items": [{"id": "p_5285", "content": "Tacrolimus [SEP] A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity ", "score": 1, "type": null, "tokenized_content": [2, 21801, 3, 43, 23929, 2261, 3937, 2037, 1920, 3733, 13150, 1927, 43, 3943, 1927, 22874, 4894, 3711, 26605, 8134, 1988, 2258, 3206, 12910, 2455, 3]}]}
{"query": {"id": "q_5286", "content": "hypertension [SEP] t. The clinical utility of FK 506 is complicated by substantial hypertension and nephrotoxicity. To clarify the mechanisms of FK 506-induced", "tokenized_content": [2, 5579, 3, 62, 18, 1920, 2535, 8531, 1927, 13134, 29202, 1977, 9881, 2007, 6317, 5579, 1930, 27880, 18, 1942, 11012, 1920, 3531, 1927, 13134, 29202, 17, 2719, 3]}, "items": [{"id": "p_5286", "content": "Hypertension [SEP] Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is c", "score": 1, "type": null, "tokenized_content": [2, 5579, 3, 23334, 2149, 5510, 6624, 2877, 3772, 18, 2454, 1990, 3137, 17093, 12, 2877, 3772, 7063, 13, 16, 5579, 1977, 45, 3]}]}
{"query": {"id": "q_5287", "content": "nephrotoxicity [SEP] tility of FK 506 is complicated by substantial hypertension and nephrotoxicity. To clarify the mechanisms of FK 506-induced hypertension, we s", "tokenized_content": [2, 27880, 3, 10935, 1999, 1927, 13134, 29202, 1977, 9881, 2007, 6317, 5579, 1930, 27880, 18, 1942, 11012, 1920, 3531, 1927, 13134, 29202, 17, 2719, 5579, 16, 2038, 61, 3]}, "items": [{"id": "p_5287", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5288", "content": "nitric oxide [SEP] T-1 and endothelin-converting enzyme-1 (ECE-1), the endothelial nitric oxide synthase (eNOS) activity, and the expression of mRNA of eNOS an", "tokenized_content": [2, 10233, 7491, 3, 62, 17, 21, 1930, 21111, 17, 15025, 4113, 17, 21, 12, 3270, 1021, 17, 21, 13, 16, 1920, 5003, 10233, 7491, 8921, 12, 14298, 13, 2455, 16, 3]}, "items": [{"id": "p_5288", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_5289", "content": "FR 139317 [SEP] he effect of the specific endothelin type A receptor antagonist FR 139317 on FK 506-induced hypertension in rats was studied. FK 506, 5 m", "tokenized_content": [2, 2415, 13316, 6800, 1027, 3, 2234, 2495, 1927, 1920, 2487, 21111, 2601, 43, 3148, 8151, 2415, 13316, 6800, 1027, 1990, 13134, 29202, 17, 2719, 5579, 1922, 3615, 1982, 3942, 18, 3]}, "items": [{"id": "p_5289", "content": "FR 139317 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 2415, 13316, 6800, 1027, 3, 3]}]}
{"query": {"id": "q_5290", "content": "NO [SEP] rting enzyme-1 (ECE-1), the endothelial nitric oxide synthase (eNOS) activity, and the expression of mRNA of eNOS and C-type natri", "tokenized_content": [2, 2239, 3, 4341, 1941, 4113, 17, 21, 12, 3270, 1021, 17, 21, 13, 16, 1920, 5003, 10233, 7491, 8921, 12, 14298, 13, 2455, 16, 1930, 1920, 2294, 1927, 3616, 1927, 3]}, "items": [{"id": "p_5290", "content": "Nitric Oxide [SEP] A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Ni", "score": 1, "type": null, "tokenized_content": [2, 10233, 7491, 3, 43, 3294, 6917, 4422, 4152, 24904, 2007, 43, 5386, 1927, 6492, 2094, 16, 6653, 2037, 9732, 2007, 10233, 7491, 8921, 18, 7781, 3]}]}
{"query": {"id": "q_5291", "content": "Suxamethonium [SEP] Suxamethonium induced prolonged apnea in a patient receiving electroconvulsiv", "tokenized_content": [2, 2020, 11414, 23568, 15414, 3, 2020, 11414, 23568, 15414, 2719, 7171, 17578, 1922, 43, 2774, 5962, 13142, 12766, 6325, 2068, 3]}, "items": [{"id": "p_5291", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_5292", "content": "apnea [SEP] Suxamethonium induced prolonged apnea in a patient receiving electroconvulsive therapy.", "tokenized_content": [2, 17578, 3, 2020, 11414, 23568, 15414, 2719, 7171, 17578, 1922, 43, 2774, 5962, 13142, 12766, 13042, 3181, 18, 3]}, "items": [{"id": "p_5292", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_5293", "content": "Suxamethonium [SEP] Suxamethonium causes prolonged apnea in patients in whom pseudocholinesterase", "tokenized_content": [2, 2020, 11414, 23568, 15414, 3, 2020, 11414, 23568, 15414, 5092, 7171, 17578, 1922, 2132, 1922, 8566, 11520, 27556, 3]}, "items": [{"id": "p_5293", "content": "Succinylcholine [SEP] A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxan", "score": 1, "type": null, "tokenized_content": [2, 13791, 2199, 11603, 3, 43, 21920, 7345, 3760, 7327, 2031, 5394, 2251, 1922, 1920, 2386, 1927, 2496, 13788, 16, 9140, 16, 2014, 14220, 18, 2176, 1977, 43, 24999, 7327, 1928, 3]}]}
{"query": {"id": "q_5294", "content": "apnea [SEP] Suxamethonium causes prolonged apnea in patients in whom pseudocholinesterase enzyme gets deactivate", "tokenized_content": [2, 17578, 3, 2020, 11414, 23568, 15414, 5092, 7171, 17578, 1922, 2132, 1922, 8566, 11520, 27556, 4113, 23105, 30097, 2341, 17370, 2057, 3]}, "items": [{"id": "p_5294", "content": "Apnea [SEP] A transient absence of spontaneous respiration.\n    ", "score": 1, "type": null, "tokenized_content": [2, 17578, 3, 43, 6809, 3905, 1927, 6242, 11695, 18, 3]}]}
{"query": {"id": "q_5295", "content": "organophosphorus (OP) poisons [SEP] atients in whom pseudocholinesterase enzyme gets deactivated by organophosphorus (OP) poisons. Here, we present a similar incident in a severely depressed pa", "tokenized_content": [2, 3090, 16847, 1957, 12, 2494, 13, 15501, 1036, 3, 2019, 6746, 1922, 8566, 11520, 27556, 4113, 23105, 30097, 2341, 17370, 2013, 2007, 3090, 16847, 1957, 12, 2494, 13, 15501, 1036, 3]}, "items": [{"id": "p_5295", "content": "Organophosphorus Compounds [SEP] Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of syn", "score": 1, "type": null, "tokenized_content": [2, 3090, 16847, 1957, 4300, 3, 6805, 4300, 1988, 5531, 15156, 1966, 1925, 12328, 3131, 1927, 1920, 5388, 18, 3063, 2441, 2052, 26300, 1977, 4949, 6472, 1927, 2540, 3]}]}
{"query": {"id": "q_5296", "content": "depressed [SEP] (OP) poisons. Here, we present a similar incident in a severely depressed patient who received electroconvulsive therapy (ECT). Prolonged", "tokenized_content": [2, 11365, 3, 12, 2494, 13, 15501, 1036, 18, 3410, 16, 2038, 2481, 43, 2551, 9706, 1922, 43, 10561, 11365, 2774, 2746, 4004, 13142, 12766, 13042, 3181, 12, 7495, 13, 18, 3]}, "items": [{"id": "p_5296", "content": "Depressive Disorder [SEP] An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood distur", "score": 1, "type": null, "tokenized_content": [2, 7745, 4770, 3, 1925, 11863, 4770, 16687, 2007, 3108, 43, 17156, 18151, 9494, 2014, 3257, 1927, 4501, 2014, 28282, 1922, 10616, 4209, 18, 1920, 9494, 3653, 1949, 3]}]}
{"query": {"id": "q_5297", "content": "OP compound [SEP] r case ensued because the information about suicidal attempt by OP compound was concealed from the treating team.", "tokenized_content": [2, 2494, 3547, 3, 60, 3087, 4847, 6436, 2882, 1920, 2988, 3001, 14759, 9289, 2007, 2494, 3547, 1982, 23413, 1919, 2037, 1920, 8247, 7072, 18, 3]}, "items": [{"id": "p_5297", "content": "Organophosphorus Compounds [SEP] Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of syn", "score": 1, "type": null, "tokenized_content": [2, 3090, 16847, 1957, 4300, 3, 6805, 4300, 1988, 5531, 15156, 1966, 1925, 12328, 3131, 1927, 1920, 5388, 18, 3063, 2441, 2052, 26300, 1977, 4949, 6472, 1927, 2540, 3]}]}
{"query": {"id": "q_5298", "content": "bupropion [SEP] The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reu", "tokenized_content": [2, 22955, 2928, 2001, 3, 1920, 2564, 1927, 1920, 24017, 22955, 2928, 2001, 1990, 4005, 5702, 5273, 2719, 2007, 43, 5328, 11153, 1964, 1032, 3]}, "items": [{"id": "p_5298", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_5299", "content": "sexual dysfunction [SEP] The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double-b", "tokenized_content": [2, 5702, 5273, 3, 1920, 2564, 1927, 1920, 24017, 22955, 2928, 2001, 1990, 4005, 5702, 5273, 2719, 2007, 43, 5328, 11153, 22957, 4106, 30, 43, 4825, 17, 44, 3]}, "items": [{"id": "p_5299", "content": "Sexual Dysfunction, Physiological [SEP] Physiological disturbances in normal sexual performance in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5702, 5273, 16, 5005, 3, 5005, 12654, 1922, 2791, 5702, 3604, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_5300", "content": "selective serotonin reuptake inhibitor [SEP] he adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double-blind placebo-controlled and randomized study.", "tokenized_content": [2, 5328, 11153, 22957, 4106, 3, 2234, 24017, 22955, 2928, 2001, 1990, 4005, 5702, 5273, 2719, 2007, 43, 5328, 11153, 22957, 4106, 30, 43, 4825, 17, 7109, 5936, 17, 4642, 1930, 3]}, "items": [{"id": "p_5300", "content": "Serotonin Uptake Inhibitors [SEP] Compounds that specifically inhibit the reuptake of serotonin in the brain.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11153, 5047, 4472, 3, 4300, 1988, 4475, 2875, 1920, 22957, 1927, 11153, 1922, 1920, 3068, 18, 3]}]}
{"query": {"id": "q_5301", "content": "bupropion [SEP] OBJECTIVE: To determine the safety and efficacy of adjunctive bupropion sustained-release (SR) on male sexual dysfunction (SD) induced ", "tokenized_content": [2, 22955, 2928, 2001, 3, 4470, 30, 1942, 3415, 1920, 5407, 1930, 4348, 1927, 24017, 22955, 2928, 2001, 7637, 17, 4012, 12, 4581, 13, 1990, 4005, 5702, 5273, 12, 4035, 13, 3]}, "items": [{"id": "p_5301", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_5302", "content": "sexual dysfunction [SEP] efficacy of adjunctive bupropion sustained-release (SR) on male sexual dysfunction (SD) induced by a selective serotonin reuptake inhibitor (SSRI)", "tokenized_content": [2, 5702, 5273, 3, 4348, 1927, 24017, 22955, 2928, 2001, 7637, 17, 4012, 12, 4581, 13, 1990, 4005, 5702, 5273, 12, 4035, 13, 2719, 2007, 43, 5328, 11153, 22957, 4106, 12, 3]}, "items": [{"id": "p_5302", "content": "Sexual Dysfunction, Physiological [SEP] Physiological disturbances in normal sexual performance in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5702, 5273, 16, 5005, 3, 5005, 12654, 1922, 2791, 5702, 3604, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_5303", "content": "SD [SEP] ve bupropion sustained-release (SR) on male sexual dysfunction (SD) induced by a selective serotonin reuptake inhibitor (SSRI), as", "tokenized_content": [2, 4035, 3, 3428, 22955, 2928, 2001, 7637, 17, 4012, 12, 4581, 13, 1990, 4005, 5702, 5273, 12, 4035, 13, 2719, 2007, 43, 5328, 11153, 22957, 4106, 12, 29494, 13, 16, 3]}, "items": [{"id": "p_5303", "content": "Sexual Dysfunction, Physiological [SEP] Physiological disturbances in normal sexual performance in either the male or the female.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5702, 5273, 16, 5005, 3, 5005, 12654, 1922, 2791, 5702, 3604, 1922, 3108, 1920, 4005, 2014, 1920, 4232, 18, 3]}]}
{"query": {"id": "q_5304", "content": "selective serotonin reuptake inhibitor [SEP] ained-release (SR) on male sexual dysfunction (SD) induced by a selective serotonin reuptake inhibitor (SSRI), as SD is a common side-effect of SSRIs and the most eff", "tokenized_content": [2, 5328, 11153, 22957, 4106, 3, 9798, 5300, 17, 4012, 12, 4581, 13, 1990, 4005, 5702, 5273, 12, 4035, 13, 2719, 2007, 43, 5328, 11153, 22957, 4106, 12, 29494, 13, 16, 3]}, "items": [{"id": "p_5304", "content": "Serotonin Uptake Inhibitors [SEP] Compounds that specifically inhibit the reuptake of serotonin in the brain.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11153, 5047, 4472, 3, 4300, 1988, 4475, 2875, 1920, 22957, 1927, 11153, 1922, 1920, 3068, 18, 3]}]}
{"query": {"id": "q_5305", "content": "SSRI [SEP] ction (SD) induced by a selective serotonin reuptake inhibitor (SSRI), as SD is a common side-effect of SSRIs and the most effective", "tokenized_content": [2, 29494, 3, 3369, 2001, 12, 4035, 13, 2719, 2007, 43, 5328, 11153, 22957, 4106, 12, 29494, 13, 16, 1966, 4035, 1977, 43, 3059, 4159, 17, 2495, 1927, 29395, 1930, 1920, 3]}, "items": [{"id": "p_5305", "content": "Serotonin Uptake Inhibitors [SEP] Compounds that specifically inhibit the reuptake of serotonin in the brain.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11153, 5047, 4472, 3, 4300, 1988, 4475, 2875, 1920, 22957, 1927, 11153, 1922, 1920, 3068, 18, 3]}]}
{"query": {"id": "q_5306", "content": "SSRIs [SEP] nin reuptake inhibitor (SSRI), as SD is a common side-effect of SSRIs and the most effective treatments have yet to be determined. PA", "tokenized_content": [2, 29395, 3, 12117, 22957, 4106, 12, 29494, 13, 16, 1966, 4035, 1977, 43, 3059, 4159, 17, 2495, 1927, 29395, 1930, 1920, 2501, 3655, 4930, 2162, 4898, 1942, 1998, 3180, 18, 3]}, "items": [{"id": "p_5306", "content": "Serotonin Uptake Inhibitors [SEP] Compounds that specifically inhibit the reuptake of serotonin in the brain.\n    ", "score": 1, "type": null, "tokenized_content": [2, 11153, 5047, 4472, 3, 4300, 1988, 4475, 2875, 1920, 22957, 1927, 11153, 1922, 1920, 3068, 18, 3]}]}
{"query": {"id": "q_5307", "content": "Erectile Dysfunction [SEP] le Function (IIEF), Arizona Sexual Experience Scale (ASEX), and Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) (secondary outcome ", "tokenized_content": [2, 24686, 5273, 3, 2071, 2347, 12, 2890, 7726, 13, 16, 30079, 5702, 4848, 3536, 12, 28826, 1039, 13, 16, 1930, 24686, 5273, 12787, 1927, 2311, 8360, 12, 3347, 2664, 13, 3]}, "items": [{"id": "p_5307", "content": "Erectile Dysfunction [SEP] The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.\n    ", "score": 1, "type": null, "tokenized_content": [2, 24686, 5273, 3, 1920, 11752, 1922, 1920, 4005, 1942, 2162, 43, 22609, 24311, 1929, 2810, 1942, 6674, 2014, 3090, 5273, 18, 3]}]}
{"query": {"id": "q_5308", "content": "Bupropion [SEP]  by the duration of SD, type of SSRI used and age. CONCLUSIONS: Bupropion is an effective treatment for male SD induced by SSRIs. These r", "tokenized_content": [2, 22955, 2928, 2001, 3, 2007, 1920, 4392, 1927, 4035, 16, 2601, 1927, 29494, 2251, 1930, 2632, 18, 4355, 30, 22955, 2928, 2001, 1977, 1925, 3655, 2311, 1958, 4005, 4035, 2719, 3]}, "items": [{"id": "p_5308", "content": "Bupropion [SEP] A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to ", "score": 1, "type": null, "tokenized_content": [2, 22955, 2928, 2001, 3, 43, 24797, 13153, 16, 3835, 18540, 2290, 14183, 18, 1920, 2856, 1927, 2496, 4272, 7728, 1977, 2084, 2486, 7372, 16, 2308, 2176, 3731, 3267, 1942, 3]}]}
{"query": {"id": "q_5309", "content": "Lamivudine [SEP] Lamivudine for the prevention of hepatitis B virus reactivation in hepatit", "tokenized_content": [2, 30208, 3, 30208, 1958, 1920, 5455, 1927, 7977, 44, 3413, 14859, 1922, 5746, 1932, 3]}, "items": [{"id": "p_5309", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_5310", "content": "hepatitis B [SEP] Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis-B surface antigen (HBSAG) serop", "tokenized_content": [2, 7977, 44, 3, 30208, 1958, 1920, 5455, 1927, 7977, 44, 3413, 14859, 1922, 7977, 17, 44, 3154, 4730, 12, 17596, 13, 2375, 2011, 3]}, "items": [{"id": "p_5310", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_5311", "content": "hepatitis-B surface antigen [SEP] ivudine for the prevention of hepatitis B virus reactivation in hepatitis-B surface antigen (HBSAG) seropositive cancer patients undergoing cytotoxic chemo", "tokenized_content": [2, 7977, 17, 44, 3154, 4730, 3, 4370, 20597, 1958, 1920, 5455, 1927, 7977, 44, 3413, 14859, 1922, 7977, 17, 44, 3154, 4730, 12, 17596, 13, 20202, 2539, 2132, 7258, 8377, 3]}, "items": [{"id": "p_5311", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_5312", "content": "HBSAG [SEP]  hepatitis B virus reactivation in hepatitis-B surface antigen (HBSAG) seropositive cancer patients undergoing cytotoxic chemotherapy", "tokenized_content": [2, 17596, 3, 7977, 44, 3413, 14859, 1922, 7977, 17, 44, 3154, 4730, 12, 17596, 13, 20202, 2539, 2132, 7258, 8377, 5318, 3]}, "items": [{"id": "p_5312", "content": "Hepatitis B Surface Antigens [SEP] Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several s", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3154, 7769, 3, 2690, 7977, 44, 7769, 2435, 1990, 1920, 3154, 1927, 1920, 11434, 1021, 7022, 1930, 1990, 1920, 2036, 2943, 12974, 1930, 11755, 5569, 18, 2980, 61, 3]}]}
{"query": {"id": "q_5313", "content": "cancer [SEP] eactivation in hepatitis-B surface antigen (HBSAG) seropositive cancer patients undergoing cytotoxic chemotherapy.", "tokenized_content": [2, 2539, 3, 27848, 2113, 1943, 1922, 7977, 17, 44, 3154, 4730, 12, 17596, 13, 20202, 2539, 2132, 7258, 8377, 5318, 18, 3]}, "items": [{"id": "p_5313", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5314", "content": "Hepatitis B [SEP] Hepatitis B virus (HBV) is one of the major causes of chronic liver disease", "tokenized_content": [2, 7977, 44, 3, 7977, 44, 3413, 12, 8738, 13, 1977, 2340, 1927, 1920, 3044, 5092, 1927, 3724, 3568, 2573, 3]}, "items": [{"id": "p_5314", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_5315", "content": "liver disease [SEP] Hepatitis B virus (HBV) is one of the major causes of chronic liver disease worldwide. Cancer patients who are chronic carriers of HBV have", "tokenized_content": [2, 3568, 2573, 3, 7977, 44, 3413, 12, 8738, 13, 1977, 2340, 1927, 1920, 3044, 5092, 1927, 3724, 3568, 2573, 8563, 18, 2539, 2132, 2746, 2032, 3724, 8974, 1927, 8738, 2162, 3]}, "items": [{"id": "p_5315", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_5316", "content": "Cancer [SEP]  is one of the major causes of chronic liver disease worldwide. Cancer patients who are chronic carriers of HBV have a higher hepatic ", "tokenized_content": [2, 2539, 3, 1977, 2340, 1927, 1920, 3044, 5092, 1927, 3724, 3568, 2573, 8563, 18, 2539, 2132, 2746, 2032, 3724, 8974, 1927, 8738, 2162, 43, 2580, 6095, 3]}, "items": [{"id": "p_5316", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5317", "content": "hepatic complication [SEP] . Cancer patients who are chronic carriers of HBV have a higher hepatic complication rate while receiving cytotoxic chemotherapy (CT) and this has m", "tokenized_content": [2, 6095, 9388, 3, 18, 2539, 2132, 2746, 2032, 3724, 8974, 1927, 8738, 2162, 43, 2580, 6095, 9388, 2769, 2679, 5962, 8377, 5318, 12, 3369, 13, 1930, 2052, 2258, 55, 3]}, "items": [{"id": "p_5317", "content": "Liver Diseases [SEP] Pathological processes of the LIVER.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3568, 3902, 3, 6598, 4028, 1927, 1920, 3568, 18, 3]}]}
{"query": {"id": "q_5318", "content": "cancer [SEP]  has mainly been attributed to HBV reactivation. In this study, cancer patients who have solid and hematological malignancies with chr", "tokenized_content": [2, 2539, 3, 2258, 4994, 2252, 6898, 1942, 8738, 14859, 18, 1922, 2052, 2161, 16, 2539, 2132, 2746, 2162, 5358, 1930, 17339, 10672, 1956, 8777, 3]}, "items": [{"id": "p_5318", "content": "Neoplasms [SEP] New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and me", "score": 1, "type": null, "tokenized_content": [2, 15347, 3, 2814, 4552, 2905, 1927, 2960, 18, 6558, 15347, 2146, 43, 3430, 4647, 1927, 21695, 6646, 1930, 2162, 1920, 3879, 1927, 6254, 1930, 2142, 3]}]}
{"query": {"id": "q_5319", "content": "hematological malignancies [SEP] reactivation. In this study, cancer patients who have solid and hematological malignancies with chronic HBV infection received the antiviral agent lamivud", "tokenized_content": [2, 17339, 10672, 3, 14859, 18, 1922, 2052, 2161, 16, 2539, 2132, 2746, 2162, 5358, 1930, 17339, 10672, 1956, 3724, 8738, 2909, 4004, 1920, 10129, 5899, 8282, 2068, 2009, 3]}, "items": [{"id": "p_5319", "content": "Hematologic Neoplasms [SEP] Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the vari", "score": 1, "type": null, "tokenized_content": [2, 18251, 15347, 3, 15347, 4810, 1922, 1920, 2877, 1930, 2877, 17, 7402, 2960, 12, 1920, 3622, 6599, 1930, 13388, 2960, 13, 18, 1920, 29200, 4952, 2032, 1920, 2309, 3]}]}
{"query": {"id": "q_5320", "content": "HBV infection [SEP] ents who have solid and hematological malignancies with chronic HBV infection received the antiviral agent lamivudine prior and during CT com", "tokenized_content": [2, 8738, 2909, 3, 8496, 1036, 2746, 2162, 5358, 1930, 17339, 10672, 1956, 3724, 8738, 2909, 4004, 1920, 10129, 5899, 30208, 3432, 1930, 2409, 3369, 2008, 3]}, "items": [{"id": "p_5320", "content": "Hepatitis B [SEP] INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transm", "score": 1, "type": null, "tokenized_content": [2, 7977, 44, 3, 4531, 1927, 1920, 3568, 1922, 5209, 4189, 2007, 43, 7210, 1927, 1920, 24343, 4116, 10776, 2175, 11074, 9487, 16, 7977, 44, 3413, 18, 2176, 1977, 5985, 4074, 3]}]}
{"query": {"id": "q_5321", "content": "lamivudine [SEP] nancies with chronic HBV infection received the antiviral agent lamivudine prior and during CT compared with historical control group who ", "tokenized_content": [2, 30208, 3, 3529, 3349, 1918, 1956, 3724, 8738, 2909, 4004, 1920, 10129, 5899, 30208, 3432, 1930, 2409, 3369, 2452, 1956, 12523, 2285, 2210, 2746, 3]}, "items": [{"id": "p_5321", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_5322", "content": "lamivudin [SEP] nancies with chronic HBV infection received the antiviral agent lamivudine prior and during CT compared with historical control group who", "tokenized_content": [2, 8282, 2068, 14287, 3, 3529, 3349, 1918, 1956, 3724, 8738, 2909, 4004, 1920, 10129, 5899, 30208, 3432, 1930, 2409, 3369, 2452, 1956, 12523, 2285, 2210, 2746, 3]}, "items": [{"id": "p_5322", "content": "Lamivudine [SEP] A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It i", "score": 1, "type": null, "tokenized_content": [2, 30208, 3, 43, 5267, 13335, 4106, 1930, 26112, 8293, 12696, 5729, 1922, 2154, 43, 12585, 6761, 14732, 1036, 1920, 23, 11, 5056, 1927, 1920, 9412, 2217, 6335, 18, 2176, 51, 3]}]}
{"query": {"id": "q_5323", "content": "hepatitis [SEP] f our control group (n= 50), 21 patients (42%) were established hepatitis. Twelve (24%) of them were evaluated as severe hepatitis. In th", "tokenized_content": [2, 7977, 3, 48, 2342, 2285, 2210, 12, 56, 33, 2761, 13, 16, 2900, 2132, 12, 3858, 9, 13, 1985, 4379, 7977, 18, 12367, 12, 2686, 9, 13, 1927, 3581, 1985, 3]}, "items": [{"id": "p_5323", "content": "Drug-Induced Liver Injury [SEP] A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug ", "score": 1, "type": null, "tokenized_content": [2, 2838, 17, 2719, 3568, 4047, 3, 43, 5648, 1927, 2535, 3568, 3902, 6485, 2037, 5809, 6503, 6754, 1942, 3939, 3568, 4574, 16, 4189, 2007, 4195, 16, 2838, 3]}]}
{"query": {"id": "q_5324", "content": "alanine [SEP] rison of the mean ALT values revealed significantly higher mean alanine aminotransferase (ALT) values in the control group than the pro", "tokenized_content": [2, 10504, 3, 2511, 1916, 1927, 1920, 2667, 8387, 2851, 3404, 2567, 2580, 2667, 10504, 15817, 12, 8387, 13, 2851, 1922, 1920, 2285, 2210, 2254, 1920, 1965, 3]}, "items": [{"id": "p_5324", "content": "Alanine [SEP] A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transaminatio", "score": 1, "type": null, "tokenized_content": [2, 10504, 3, 43, 2447, 17, 4415, 3835, 2687, 1988, 5110, 1922, 2149, 2428, 1922, 2496, 3294, 3360, 1922, 3582, 18, 2176, 1977, 4152, 2037, 11867, 2007, 2127, 3717, 1968, 1037, 3]}]}
{"query": {"id": "q_5325", "content": "nucleoside [SEP] y. Further studies are needed to determine the most appropriate nucleoside or nucleotide analogue for antiviral prophylaxis during CT and ", "tokenized_content": [2, 18015, 3, 67, 18, 2520, 2351, 2032, 4500, 1942, 3415, 1920, 2501, 4703, 18015, 2014, 5489, 12980, 1958, 10129, 12725, 2409, 3369, 1930, 3]}, "items": [{"id": "p_5325", "content": "Nucleosides [SEP] Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)\n    ", "score": 1, "type": null, "tokenized_content": [2, 18015, 1036, 3, 19700, 2014, 21611, 11137, 8765, 1942, 43, 17870, 2014, 26405, 2217, 18, 12, 2037, 10721, 10, 17725, 1036, 11937, 16, 43, 29815, 1927, 10072, 16, 18117, 3347, 13, 3]}]}
{"query": {"id": "q_5326", "content": "nucleotide [SEP] dies are needed to determine the most appropriate nucleoside or nucleotide analogue for antiviral prophylaxis during CT and the optimal du", "tokenized_content": [2, 5489, 3, 21354, 2032, 4500, 1942, 3415, 1920, 2501, 4703, 18015, 2014, 5489, 12980, 1958, 10129, 12725, 2409, 3369, 1930, 1920, 5419, 4855, 3]}, "items": [{"id": "p_5326", "content": "Nucleotides [SEP] The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar", "score": 1, "type": null, "tokenized_content": [2, 9519, 3, 1920, 14457, 5701, 2037, 2154, 2678, 2014, 3146, 11039, 2032, 6857, 18, 2611, 3149, 1927, 43, 19700, 2014, 21611, 5170, 16, 43, 9412, 2217, 9523, 3]}]}
{"query": {"id": "q_5327", "content": "Ginsenoside Rg1 [SEP] Ginsenoside Rg1 restores the impairment of learning induced by chronic morphine", "tokenized_content": [2, 27601, 8028, 9372, 1009, 3, 27601, 8028, 9372, 1009, 24423, 1920, 6159, 1927, 4809, 2719, 2007, 3724, 11553, 3]}, "items": [{"id": "p_5327", "content": "ginsenoside Rg1 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 27601, 8028, 9372, 1009, 3, 3]}]}
{"query": {"id": "q_5328", "content": "impairment of learning [SEP] Ginsenoside Rg1 restores the impairment of learning induced by chronic morphine administration in rats.", "tokenized_content": [2, 6159, 1927, 4809, 3, 27601, 8028, 9372, 1009, 24423, 1920, 6159, 1927, 4809, 2719, 2007, 3724, 11553, 4183, 1922, 3615, 18, 3]}, "items": [{"id": "p_5328", "content": "Learning Disorders [SEP] Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to ", "score": 1, "type": null, "tokenized_content": [2, 4809, 4414, 3, 2961, 4378, 2007, 43, 2228, 12156, 2192, 1925, 2725, 11, 61, 6523, 2237, 1927, 12744, 1930, 2310, 3682, 1942, 3]}]}
{"query": {"id": "q_5329", "content": "morphine [SEP] side Rg1 restores the impairment of learning induced by chronic morphine administration in rats.", "tokenized_content": [2, 11553, 3, 4159, 9372, 1009, 24423, 1920, 6159, 1927, 4809, 2719, 2007, 3724, 11553, 4183, 1922, 3615, 18, 3]}, "items": [{"id": "p_5329", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_5330", "content": "Rg1 [SEP] Rg1, as a ginsenoside extracted from Panax ginseng, could ameliorat", "tokenized_content": [2, 9372, 1009, 3, 9372, 1009, 16, 1966, 43, 27601, 8028, 5210, 2037, 3797, 3013, 24739, 16, 2578, 11963, 1926, 3]}, "items": [{"id": "p_5330", "content": "ginsenoside Rg1 [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 27601, 8028, 9372, 1009, 3, 3]}]}
{"query": {"id": "q_5331", "content": "ginsenoside [SEP] Rg1, as a ginsenoside extracted from Panax ginseng, could ameliorate spatial learning", "tokenized_content": [2, 27601, 8028, 3, 9372, 1009, 16, 1966, 43, 27601, 8028, 5210, 2037, 3797, 3013, 24739, 16, 2578, 20611, 5067, 4809, 3]}, "items": [{"id": "p_5331", "content": "Ginsenosides [SEP] Dammarane type triterpene saponins based mainly on the aglycones, protopanaxadiol and protopanaxatriol.\n    ", "score": 1, "type": null, "tokenized_content": [2, 27601, 17079, 3, 3787, 19252, 2516, 2601, 5083, 1967, 17125, 1021, 28689, 1036, 2454, 4994, 1990, 1920, 2260, 19602, 3965, 16, 23583, 6528, 3013, 10609, 1930, 23583, 6528, 3013, 12078, 11149, 18, 3]}]}
{"query": {"id": "q_5332", "content": "learning impairment [SEP] senoside extracted from Panax ginseng, could ameliorate spatial learning impairment. Previous studies have demonstrated that Rg1 might be a useful ", "tokenized_content": [2, 4809, 6159, 3, 6964, 8028, 5210, 2037, 3797, 3013, 24739, 16, 2578, 20611, 5067, 4809, 6159, 18, 2555, 2351, 2162, 3161, 1988, 9372, 1009, 3284, 1998, 43, 4707, 3]}, "items": [{"id": "p_5332", "content": "Learning Disorders [SEP] Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to ", "score": 1, "type": null, "tokenized_content": [2, 4809, 4414, 3, 2961, 4378, 2007, 43, 2228, 12156, 2192, 1925, 2725, 11, 61, 6523, 2237, 1927, 12744, 1930, 2310, 3682, 1942, 3]}]}
{"query": {"id": "q_5333", "content": "morphine [SEP] gent for the prevention and treatment of the adverse effects of morphine. The aim of this study was to investigate the effect of Rg1 on ", "tokenized_content": [2, 11553, 3, 11994, 1958, 1920, 5455, 1930, 2311, 1927, 1920, 5246, 2564, 1927, 11553, 18, 1920, 3774, 1927, 2052, 2161, 1982, 1942, 4482, 1920, 2495, 1927, 9372, 1009, 1990, 3]}, "items": [{"id": "p_5333", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_5334", "content": "Morphine [SEP] he Morris water maze. The results showed that rats treated with Morphine/Rg1 decreased escape latency and increased the time spent in pl", "tokenized_content": [2, 11553, 3, 2234, 20376, 3224, 14476, 18, 1920, 2274, 2594, 1988, 3615, 2868, 1956, 11553, 19, 9372, 1009, 3261, 11781, 9393, 1930, 2502, 1920, 2367, 9934, 1922, 2123, 3]}, "items": [{"id": "p_5334", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_5335", "content": "N-methyl-D-aspartate [SEP] rphine/Rg1-treated rats; this restoration could be inhibited by N-methyl-D-aspartate (NMDA) receptor antagonist MK801. We conclude that Rg1 may sign", "tokenized_content": [2, 56, 17, 4963, 17, 46, 17, 12878, 3, 4822, 7969, 2912, 19, 9372, 1009, 17, 2868, 3615, 31, 2052, 12010, 2578, 1998, 5069, 2007, 56, 17, 4963, 17, 46, 17, 3]}, "items": [{"id": "p_5335", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_5336", "content": "NMDA [SEP] s; this restoration could be inhibited by N-methyl-D-aspartate (NMDA) receptor antagonist MK801. We conclude that Rg1 may significan", "tokenized_content": [2, 10976, 3, 61, 31, 2052, 12010, 2578, 1998, 5069, 2007, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 8151, 10539, 4476, 1009, 18, 2038, 7676, 1988, 9372, 3]}, "items": [{"id": "p_5336", "content": "N-Methylaspartate [SEP] An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NM", "score": 1, "type": null, "tokenized_content": [2, 56, 17, 4963, 13432, 5263, 2010, 3, 1925, 3835, 2687, 1988, 16, 1966, 1920, 46, 17, 15348, 16, 1977, 1920, 11266, 7829, 1958, 1920, 10976, 3148, 8856, 1927, 7627, 4086, 12, 4086, 16, 2943, 3]}]}
{"query": {"id": "q_5337", "content": "MK801 [SEP] be inhibited by N-methyl-D-aspartate (NMDA) receptor antagonist MK801. We conclude that Rg1 may significantly improve the spatial lea", "tokenized_content": [2, 10539, 4476, 1009, 3, 1998, 5069, 2007, 56, 17, 4963, 17, 46, 17, 12878, 12, 10976, 13, 3148, 8151, 10539, 4476, 1009, 18, 2038, 7676, 1988, 9372, 1009, 2278, 2567, 3]}, "items": [{"id": "p_5337", "content": "Dizocilpine Maleate [SEP] A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The dr", "score": 1, "type": null, "tokenized_content": [2, 2137, 13642, 10401, 12184, 4005, 2010, 3, 43, 6828, 22849, 9626, 2572, 2320, 8151, 1927, 1920, 10976, 3148, 12, 4086, 16, 56, 17, 4963, 17, 46, 17, 12878, 13, 2251, 4994, 1966, 43, 2659, 5229, 18, 1920, 2324, 3]}]}
{"query": {"id": "q_5338", "content": "heparin [SEP] A study on the effect of the duration of subcutaneous heparin injection on bruising and pain.", "tokenized_content": [2, 9962, 3, 43, 2161, 1990, 1920, 2495, 1927, 1920, 4392, 1927, 8634, 9962, 4107, 1990, 28171, 4007, 1930, 3594, 18, 3]}, "items": [{"id": "p_5338", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_5339", "content": "bruising [SEP] the effect of the duration of subcutaneous heparin injection on bruising and pain.", "tokenized_content": [2, 28171, 4007, 3, 1920, 2495, 1927, 1920, 4392, 1927, 8634, 9962, 4107, 1990, 28171, 4007, 1930, 3594, 18, 3]}, "items": [{"id": "p_5339", "content": "Contusions [SEP] Injuries resulting in hemorrhage, usually manifested in the skin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2120, 3910, 3, 8209, 3864, 1922, 10489, 16, 5394, 16687, 1922, 1920, 4407, 18, 3]}]}
{"query": {"id": "q_5340", "content": "pain [SEP]  the duration of subcutaneous heparin injection on bruising and pain.", "tokenized_content": [2, 3594, 3, 1920, 4392, 1927, 8634, 9962, 4107, 1990, 28171, 4007, 1930, 3594, 18, 3]}, "items": [{"id": "p_5340", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_5341", "content": "bruising [SEP] as carried out to determine the effect of injection duration on bruising and pain following the administration of the subcutaneous injec", "tokenized_content": [2, 28171, 4007, 3, 1966, 4371, 2397, 1942, 3415, 1920, 2495, 1927, 4107, 4392, 1990, 28171, 4007, 1930, 3594, 2894, 1920, 4183, 1927, 1920, 8634, 2831, 1940, 3]}, "items": [{"id": "p_5341", "content": "Contusions [SEP] Injuries resulting in hemorrhage, usually manifested in the skin.\n    ", "score": 1, "type": null, "tokenized_content": [2, 2120, 3910, 3, 8209, 3864, 1922, 10489, 16, 5394, 16687, 1922, 1920, 4407, 18, 3]}]}
{"query": {"id": "q_5342", "content": "pain [SEP] t to determine the effect of injection duration on bruising and pain following the administration of the subcutaneous injection of h", "tokenized_content": [2, 3594, 3, 62, 1942, 3415, 1920, 2495, 1927, 4107, 4392, 1990, 28171, 4007, 1930, 3594, 2894, 1920, 4183, 1927, 1920, 8634, 4107, 1927, 50, 3]}, "items": [{"id": "p_5342", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_5343", "content": "heparin [SEP] n following the administration of the subcutaneous injection of heparin. BACKGROUND: Although different methods to prevent bruising and", "tokenized_content": [2, 9962, 3, 56, 2894, 1920, 4183, 1927, 1920, 8634, 4107, 1927, 9962, 18, 3872, 30, 2876, 2413, 2860, 1942, 4625, 28171, 4007, 1930, 3]}, "items": [{"id": "p_5343", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_5344", "content": "Heparin [SEP] d of 50 patients to whom subcutaneous heparin was administered. Heparin was injected over 10 seconds on the right abdominal site and 30", "tokenized_content": [2, 9962, 3, 46, 1927, 2761, 2132, 1942, 8566, 8634, 9962, 1982, 5254, 18, 9962, 1982, 5624, 2338, 2119, 9362, 1990, 1920, 3659, 6900, 3200, 1930, 2627, 3]}, "items": [{"id": "p_5344", "content": "Heparin [SEP] A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges", "score": 1, "type": null, "tokenized_content": [2, 9962, 3, 43, 3626, 9931, 3422, 13580, 9466, 5333, 1927, 5557, 7516, 1927, 26649, 46, 17, 28627, 1930, 46, 17, 17102, 1935, 2687, 1956, 5141, 3717, 1935, 18142, 3]}]}
{"query": {"id": "q_5345", "content": "Pain [SEP] he size of the bruising was smaller in the 30-second injection. Pain intensity and pain period were statistically significantly lowe", "tokenized_content": [2, 3594, 3, 2234, 3081, 1927, 1920, 28171, 4007, 1982, 5322, 1922, 1920, 2627, 17, 2812, 4107, 18, 3594, 4266, 1930, 3594, 3047, 1985, 4388, 2567, 2330, 1021, 3]}, "items": [{"id": "p_5345", "content": "Pain [SEP] An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.\n    ", "score": 1, "type": null, "tokenized_content": [2, 3594, 3, 1925, 25429, 15826, 2719, 2007, 24218, 5458, 2154, 2032, 3330, 2007, 5507, 17970, 1036, 1927, 19034, 3558, 18, 3]}]}
{"query": {"id": "q_5346", "content": "reserpine [SEP] Acute reserpine and subchronic haloperidol treatments change synaptosomal brain", "tokenized_content": [2, 1995, 1915, 12184, 3, 3939, 1995, 1915, 12184, 1930, 28533, 26242, 25107, 4930, 3185, 14009, 4969, 3068, 3]}, "items": [{"id": "p_5346", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_5347", "content": "haloperidol [SEP] Acute reserpine and subchronic haloperidol treatments change synaptosomal brain glutamate uptake and elici", "tokenized_content": [2, 25107, 3, 3939, 1995, 1915, 12184, 1930, 28533, 26242, 25107, 4930, 3185, 14009, 4969, 3068, 7627, 5047, 1930, 6810, 1033, 3]}, "items": [{"id": "p_5347", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5348", "content": "glutamate [SEP] and subchronic haloperidol treatments change synaptosomal brain glutamate uptake and elicit orofacial dyskinesia in rats.", "tokenized_content": [2, 7627, 3, 1930, 28533, 26242, 25107, 4930, 3185, 14009, 4969, 3068, 7627, 5047, 1930, 12095, 25027, 18703, 3890, 26682, 1922, 3615, 18, 3]}, "items": [{"id": "p_5348", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_5349", "content": "orofacial dyskinesia [SEP] reatments change synaptosomal brain glutamate uptake and elicit orofacial dyskinesia in rats.", "tokenized_content": [2, 25027, 18703, 3890, 26682, 3, 1964, 7647, 1036, 3185, 14009, 4969, 3068, 7627, 5047, 1930, 12095, 25027, 18703, 3890, 26682, 1922, 3615, 18, 3]}, "items": [{"id": "p_5349", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5350", "content": "Reserpine [SEP] Reserpine- and haloperidol-induced orofacial dyskinesia are putative anim", "tokenized_content": [2, 1995, 1915, 12184, 3, 1995, 1915, 12184, 17, 1930, 25107, 17, 2719, 25027, 18703, 3890, 26682, 2032, 6770, 2963, 3]}, "items": [{"id": "p_5350", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_5351", "content": "haloperidol [SEP] Reserpine- and haloperidol-induced orofacial dyskinesia are putative animal models of tard", "tokenized_content": [2, 25107, 3, 1995, 1915, 12184, 17, 1930, 25107, 17, 2719, 25027, 18703, 3890, 26682, 2032, 6770, 4027, 3130, 1927, 14517, 1007, 3]}, "items": [{"id": "p_5351", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5352", "content": "orofacial dyskinesia [SEP] Reserpine- and haloperidol-induced orofacial dyskinesia are putative animal models of tardive dyskinesia (TD) whose pat", "tokenized_content": [2, 25027, 18703, 3890, 26682, 3, 1995, 1915, 12184, 17, 1930, 25107, 17, 2719, 25027, 18703, 3890, 26682, 2032, 6770, 4027, 3130, 1927, 14517, 7408, 1961, 3890, 26682, 12, 6888, 13, 3]}, "items": [{"id": "p_5352", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5353", "content": "tardive dyskinesia [SEP] idol-induced orofacial dyskinesia are putative animal models of tardive dyskinesia (TD) whose pathophysiology has been related to free radical gen", "tokenized_content": [2, 14517, 7408, 1961, 3890, 26682, 3, 23783, 1024, 17, 2719, 25027, 18703, 3890, 26682, 2032, 6770, 4027, 3130, 1927, 14517, 7408, 1961, 3890, 26682, 12, 6888, 13, 6098, 11985, 2258, 3]}, "items": [{"id": "p_5353", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5354", "content": "TD [SEP] al dyskinesia are putative animal models of tardive dyskinesia (TD) whose pathophysiology has been related to free radical generat", "tokenized_content": [2, 6888, 3, 1969, 3890, 26682, 2032, 6770, 4027, 3130, 1927, 14517, 7408, 1961, 3890, 26682, 12, 6888, 13, 6098, 11985, 2258, 2252, 2712, 1942, 3294, 6917, 12774, 1031, 3]}, "items": [{"id": "p_5354", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5355", "content": "reserpine [SEP] resent study, the authors induced orofacial dyskinesia by acute reserpine and subchronic haloperidol administration to rats. Reserpine in", "tokenized_content": [2, 1995, 1915, 12184, 3, 1995, 1939, 2161, 16, 1920, 3875, 2719, 25027, 18703, 3890, 26682, 2007, 3939, 1995, 1915, 12184, 1930, 28533, 26242, 25107, 4183, 1942, 3615, 18, 1995, 1915, 3]}, "items": [{"id": "p_5355", "content": "Reserpine [SEP] An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into st", "score": 1, "type": null, "tokenized_content": [2, 1995, 1915, 12184, 3, 1925, 29951, 2435, 1922, 1920, 9398, 1927, 4313, 27142, 1945, 19894, 1019, 27453, 9830, 1019, 1930, 60, 18, 13463, 6733, 2126, 18, 1995, 1915, 12184, 7042, 1920, 5047, 1927, 16436, 2460, 1955, 3]}]}
{"query": {"id": "q_5356", "content": "Haloperidol [SEP] sion and duration of facial twitching, compared to the control. Haloperidol administration (one dose of 12 mg/kg once a week s.c.) for 4 we", "tokenized_content": [2, 25107, 3, 5998, 1916, 1930, 4392, 1927, 9567, 21596, 1941, 16, 2452, 1942, 1920, 2285, 18, 25107, 4183, 12, 2340, 3253, 1927, 2369, 2786, 19, 3621, 5361, 43, 2982, 61, 3]}, "items": [{"id": "p_5356", "content": "Haloperidol [SEP] A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoa", "score": 1, "type": null, "tokenized_content": [2, 25107, 3, 43, 7971, 17, 16057, 7650, 2199, 17, 2308, 5134, 17616, 2290, 1988, 1977, 2251, 5985, 1942, 2297, 7899, 1930, 2303, 9855, 1918, 18, 2176, 1977, 2222, 2251, 1922, 7071, 6952, 3]}]}
{"query": {"id": "q_5357", "content": "glutamate [SEP] y evaluations. After the treatments and behavioral observation, glutamate uptake by segments of the brain was analyzed. A decreased gluta", "tokenized_content": [2, 7627, 3, 67, 11761, 18, 2256, 1920, 4930, 1930, 5343, 5275, 16, 7627, 5047, 2007, 7492, 1927, 1920, 3068, 1982, 3265, 18, 43, 3261, 4354, 1019, 3]}, "items": [{"id": "p_5357", "content": "Glutamic Acid [SEP] A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in th", "score": 1, "type": null, "tokenized_content": [2, 18626, 2687, 3, 43, 2447, 17, 4415, 3835, 2687, 10414, 6966, 1922, 1920, 54, 17, 2386, 18, 18626, 2687, 1977, 1920, 2501, 3059, 11237, 15223, 1922, 1913, 3]}]}
{"query": {"id": "q_5358", "content": "orofacial diskinesia [SEP] take correlates negatively with an increase in the incidence of orofacial diskinesia. These results indicate that early changes in glutamate transpo", "tokenized_content": [2, 25027, 18703, 15598, 2613, 2126, 3, 6132, 8706, 7191, 1956, 1925, 2760, 1922, 1920, 4332, 1927, 25027, 18703, 15598, 2613, 2126, 18, 2144, 2274, 3579, 1988, 3120, 2840, 1922, 7627, 3]}, "items": [{"id": "p_5358", "content": "Dyskinesia, Drug-Induced [SEP] Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or", "score": 1, "type": null, "tokenized_content": [2, 3890, 26682, 16, 2838, 17, 2719, 3, 4552, 8264, 16, 2710, 4194, 23786, 1937, 31, 14395, 26682, 31, 18388, 31, 1930, 23357, 16, 2458, 1956, 1920, 2485, 1927, 4908, 7719, 2014, 3]}]}
{"query": {"id": "q_5359", "content": "Acute psychosis [SEP] Acute psychosis due to treatment with phenytoin in a nonepileptic patient.", "tokenized_content": [2, 3939, 15489, 3, 3939, 15489, 2810, 1942, 2311, 1956, 3037, 30177, 1922, 43, 6046, 10984, 1952, 13575, 2774, 18, 3]}, "items": [{"id": "p_5359", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_5360", "content": "phenytoin [SEP] Acute psychosis due to treatment with phenytoin in a nonepileptic patient.", "tokenized_content": [2, 3037, 30177, 3, 3939, 15489, 2810, 1942, 2311, 1956, 3037, 30177, 1922, 43, 6046, 10984, 1952, 13575, 2774, 18, 3]}, "items": [{"id": "p_5360", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_5361", "content": "psychosis [SEP] The development of psychosis related to antiepileptic drug treatment is usually attributed t", "tokenized_content": [2, 15489, 3, 1920, 2740, 1927, 15489, 2712, 1942, 29132, 2838, 2311, 1977, 5394, 6898, 62, 3]}, "items": [{"id": "p_5361", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_5362", "content": "epileptic [SEP] The development of psychosis related to antiepileptic drug treatment is usually attributed to the interaction between", "tokenized_content": [2, 16304, 3, 1920, 2740, 1927, 15489, 2712, 1942, 29132, 2838, 2311, 1977, 5394, 6898, 1942, 1920, 2835, 2192, 3]}, "items": [{"id": "p_5362", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_5363", "content": "phenytoin [SEP] ase of a nonepileptic patient who developed psychosis following phenytoin treatment for trigeminal neuralgia is described. This case sugg", "tokenized_content": [2, 3037, 30177, 3, 28826, 1927, 43, 6046, 10984, 1952, 13575, 2774, 2746, 3530, 15489, 2894, 3037, 30177, 2311, 1958, 20747, 5181, 11966, 1977, 2910, 18, 2052, 3087, 2425, 1029, 3]}, "items": [{"id": "p_5363", "content": "Phenytoin [SEP] An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mec", "score": 1, "type": null, "tokenized_content": [2, 3037, 30177, 3, 1925, 26572, 2031, 1988, 1977, 2251, 1942, 2297, 43, 4743, 5386, 1927, 10060, 18, 2176, 1977, 2222, 1925, 2246, 17, 11335, 4913, 1930, 43, 3760, 7327, 2031, 18, 1920, 10685, 3]}]}
{"query": {"id": "q_5364", "content": "trigeminal neuralgia [SEP] tient who developed psychosis following phenytoin treatment for trigeminal neuralgia is described. This case suggests that the psychotic symptoms th", "tokenized_content": [2, 20747, 5181, 11966, 3, 19108, 4905, 2746, 3530, 15489, 2894, 3037, 30177, 2311, 1958, 20747, 5181, 11966, 1977, 2910, 18, 2052, 3087, 4015, 1988, 1920, 16651, 3601, 1913, 3]}, "items": [{"id": "p_5364", "content": "Trigeminal Neuralgia [SEP] A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distributio", "score": 1, "type": null, "tokenized_content": [2, 20747, 5181, 11966, 3, 43, 4741, 4378, 2007, 7457, 9232, 1927, 3619, 3176, 3349, 2287, 3594, 11671, 2980, 9362, 2014, 4872, 1922, 1920, 6893, 19948, 1984, 3940, 3]}]}
{"query": {"id": "q_5365", "content": "psychotic symptoms [SEP]  trigeminal neuralgia is described. This case suggests that the psychotic symptoms that occur following phenytoin treatment in some epileptic pati", "tokenized_content": [2, 16651, 3601, 3, 20747, 5181, 11966, 1977, 2910, 18, 2052, 3087, 4015, 1988, 1920, 16651, 3601, 1988, 4704, 2894, 3037, 30177, 2311, 1922, 2673, 16304, 2091, 3]}, "items": [{"id": "p_5365", "content": "Psychoses, Substance-Induced [SEP] Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.\n    ", "score": 1, "type": null, "tokenized_content": [2, 9855, 1918, 16, 7311, 17, 2719, 3, 16651, 6805, 5018, 4414, 3864, 2037, 1920, 6161, 2495, 1927, 4195, 1930, 10164, 2014, 2303, 13635, 7311, 18, 3]}]}
{"query": {"id": "q_5366", "content": "seizures [SEP] c patients may be the direct result of medication, unrelated to seizures.", "tokenized_content": [2, 10060, 3, 45, 2132, 2278, 1998, 1920, 3083, 3211, 1927, 6093, 16, 10295, 1942, 10060, 18, 3]}, "items": [{"id": "p_5366", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5367", "content": "gum Arabic [SEP] The effect of treatment with gum Arabic on gentamicin nephrotoxicity in rats: a preliminary study.", "tokenized_content": [2, 20654, 7165, 1935, 3, 1920, 2495, 1927, 2311, 1956, 20654, 7165, 1935, 1990, 17144, 27880, 1922, 3615, 30, 43, 8458, 2161, 18, 3]}, "items": [{"id": "p_5367", "content": "Gum Arabic [SEP] Powdered exudate from various Acacia species, especially A. senegal (Leguminosae). It forms mucilage or syrup in water. Gum arab", "score": 1, "type": null, "tokenized_content": [2, 20654, 7165, 1935, 3, 10201, 1919, 18787, 2010, 2037, 3425, 18699, 3349, 1019, 3038, 16, 4369, 43, 18, 6964, 11253, 1024, 12, 6703, 5101, 5360, 1021, 13, 18, 2176, 4952, 3422, 19167, 2106, 2014, 11458, 3481, 1922, 3224, 18, 20654, 7165, 3]}]}
{"query": {"id": "q_5368", "content": "gentamicin [SEP] The effect of treatment with gum Arabic on gentamicin nephrotoxicity in rats: a preliminary study.", "tokenized_content": [2, 17144, 3, 1920, 2495, 1927, 2311, 1956, 20654, 7165, 1935, 1990, 17144, 27880, 1922, 3615, 30, 43, 8458, 2161, 18, 3]}, "items": [{"id": "p_5368", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_5369", "content": "nephrotoxicity [SEP] The effect of treatment with gum Arabic on gentamicin nephrotoxicity in rats: a preliminary study.", "tokenized_content": [2, 27880, 3, 1920, 2495, 1927, 2311, 1956, 20654, 7165, 1935, 1990, 17144, 27880, 1922, 3615, 30, 43, 8458, 2161, 18, 3]}, "items": [{"id": "p_5369", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5370", "content": "gum Arabic [SEP] e present work we assessed the effect of treatment of rats with gum Arabic on acute renal failure induced by gentamicin (GM) nephrotoxicit", "tokenized_content": [2, 20654, 7165, 1935, 3, 47, 2481, 2778, 2038, 3683, 1920, 2495, 1927, 2311, 1927, 3615, 1956, 20654, 7165, 1935, 1990, 3939, 4604, 4574, 2719, 2007, 17144, 12, 5711, 13, 22994, 3]}, "items": [{"id": "p_5370", "content": "Gum Arabic [SEP] Powdered exudate from various Acacia species, especially A. senegal (Leguminosae). It forms mucilage or syrup in water. Gum arab", "score": 1, "type": null, "tokenized_content": [2, 20654, 7165, 1935, 3, 10201, 1919, 18787, 2010, 2037, 3425, 18699, 3349, 1019, 3038, 16, 4369, 43, 18, 6964, 11253, 1024, 12, 6703, 5101, 5360, 1021, 13, 18, 2176, 4952, 3422, 19167, 2106, 2014, 11458, 3481, 1922, 3224, 18, 20654, 7165, 3]}]}
{"query": {"id": "q_5371", "content": "acute renal failure [SEP]  we assessed the effect of treatment of rats with gum Arabic on acute renal failure induced by gentamicin (GM) nephrotoxicity. Rats were treated wi", "tokenized_content": [2, 3939, 4604, 4574, 3, 2038, 3683, 1920, 2495, 1927, 2311, 1927, 3615, 1956, 20654, 7165, 1935, 1990, 3939, 4604, 4574, 2719, 2007, 17144, 12, 5711, 13, 27880, 18, 3615, 1985, 3]}, "items": [{"id": "p_5371", "content": "Acute Kidney Injury [SEP] Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney ", "score": 1, "type": null, "tokenized_content": [2, 3939, 5245, 4047, 3, 20135, 3378, 1922, 5245, 2347, 18, 3939, 5245, 4047, 21569, 1920, 5346, 5648, 1927, 1920, 4741, 2710, 3939, 5245, 3]}]}
{"query": {"id": "q_5372", "content": "gentamicin [SEP] tment of rats with gum Arabic on acute renal failure induced by gentamicin (GM) nephrotoxicity. Rats were treated with the vehicle (2 mL/k", "tokenized_content": [2, 17144, 3, 22377, 4905, 1927, 3615, 1956, 20654, 7165, 1935, 1990, 3939, 4604, 4574, 2719, 2007, 17144, 12, 5711, 13, 27880, 18, 3615, 1985, 2868, 1956, 1920, 6463, 12, 22, 3]}, "items": [{"id": "p_5372", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_5373", "content": "GM [SEP] s with gum Arabic on acute renal failure induced by gentamicin (GM) nephrotoxicity. Rats were treated with the vehicle (2 mL/kg of", "tokenized_content": [2, 5711, 3, 61, 1956, 20654, 7165, 1935, 1990, 3939, 4604, 4574, 2719, 2007, 17144, 12, 5711, 13, 27880, 18, 3615, 1985, 2868, 1956, 1920, 6463, 12, 22, 2646, 19, 3621, 3]}, "items": [{"id": "p_5373", "content": "Gentamicins [SEP] A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum ", "score": 1, "type": null, "tokenized_content": [2, 17144, 1036, 3, 43, 2796, 1927, 6538, 2712, 23029, 17079, 2926, 2037, 7709, 23557, 3508, 8846, 25945, 16648, 1930, 2712, 3038, 18, 2611, 2032, 4949, 17, 5648, 3]}]}
{"query": {"id": "q_5374", "content": "nephrotoxicity [SEP] th gum Arabic on acute renal failure induced by gentamicin (GM) nephrotoxicity. Rats were treated with the vehicle (2 mL/kg of distilled water", "tokenized_content": [2, 27880, 3, 1913, 20654, 7165, 1935, 1990, 3939, 4604, 4574, 2719, 2007, 17144, 12, 5711, 13, 27880, 18, 3615, 1985, 2868, 1956, 1920, 6463, 12, 22, 2646, 19, 3621, 1927, 3]}, "items": [{"id": "p_5374", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5375", "content": "Nephrotoxicity [SEP] amuscularly, during the last six days of the treatment period). Nephrotoxicity was assessed by measuring the concentrations of creatinine and ", "tokenized_content": [2, 27880, 3, 2150, 10742, 1954, 16, 2409, 1920, 4691, 3798, 3000, 1927, 1920, 2311, 3047, 13, 18, 27880, 1982, 3683, 2007, 6711, 1920, 3295, 1927, 9374, 1930, 3]}, "items": [{"id": "p_5375", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5376", "content": "creatinine [SEP]  Nephrotoxicity was assessed by measuring the concentrations of creatinine and urea in the plasma and reduced glutathione (GSH) in the kid", "tokenized_content": [2, 9374, 3, 27880, 1982, 3683, 2007, 6711, 1920, 3295, 1927, 9374, 1930, 10505, 1922, 1920, 3582, 1930, 3028, 9153, 12, 9973, 13, 1922, 1920, 4816, 3]}, "items": [{"id": "p_5376", "content": "Creatinine [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 9374, 3, 3]}]}
{"query": {"id": "q_5377", "content": "urea [SEP]  was assessed by measuring the concentrations of creatinine and urea in the plasma and reduced glutathione (GSH) in the kidney corte", "tokenized_content": [2, 10505, 3, 1982, 3683, 2007, 6711, 1920, 3295, 1927, 9374, 1930, 10505, 1922, 1920, 3582, 1930, 3028, 9153, 12, 9973, 13, 1922, 1920, 5245, 18964, 1021, 3]}, "items": [{"id": "p_5377", "content": "Urea [SEP] A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of prote", "score": 1, "type": null, "tokenized_content": [2, 10505, 3, 43, 3547, 5333, 1922, 1920, 3568, 2037, 14880, 4152, 2007, 1920, 30097, 8547, 1943, 1927, 3835, 4576, 18, 2176, 1977, 1920, 7944, 2482, 4863, 1927, 2174, 3]}]}
{"query": {"id": "q_5378", "content": "glutathione [SEP] concentrations of creatinine and urea in the plasma and reduced glutathione (GSH) in the kidney cortex, and by light microscopic examinatio", "tokenized_content": [2, 9153, 3, 3295, 1927, 9374, 1930, 10505, 1922, 1920, 3582, 1930, 3028, 9153, 12, 9973, 13, 1922, 1920, 5245, 4997, 16, 1930, 2007, 3696, 10372, 2493, 4058, 1914, 1037, 3]}, "items": [{"id": "p_5378", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_5379", "content": "GSH [SEP] s of creatinine and urea in the plasma and reduced glutathione (GSH) in the kidney cortex, and by light microscopic examination of ", "tokenized_content": [2, 9973, 3, 61, 1927, 9374, 1930, 10505, 1922, 1920, 3582, 1930, 3028, 9153, 12, 9973, 13, 1922, 1920, 5245, 4997, 16, 1930, 2007, 3696, 10372, 4981, 1927, 3]}, "items": [{"id": "p_5379", "content": "Glutathione [SEP] A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some en", "score": 1, "type": null, "tokenized_content": [2, 9153, 3, 43, 8027, 8253, 1956, 3086, 5456, 1922, 2094, 18, 2176, 14749, 1942, 4195, 1942, 5144, 3581, 2253, 6622, 1958, 11093, 16, 1977, 43, 15155, 1958, 2673, 2066, 3]}]}
{"query": {"id": "q_5380", "content": "tubular necrosis [SEP]  to 27% in the cellulose plus GM group) The GM-induced proximal tubular necrosis appeared to be slightly less severe in rats given GM together w", "tokenized_content": [2, 11755, 7476, 3, 1942, 3225, 9, 1922, 1920, 12343, 5390, 5711, 2210, 13, 1920, 5711, 17, 2719, 6863, 11755, 7476, 6209, 1942, 1998, 5733, 2941, 4010, 1922, 3615, 3258, 5711, 3]}, "items": [{"id": "p_5380", "content": "Kidney Tubular Necrosis, Acute [SEP] Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure", "score": 1, "type": null, "tokenized_content": [2, 5245, 11755, 7476, 16, 3939, 3, 3939, 5245, 4574, 3864, 2037, 12102, 1927, 4944, 2094, 1927, 1920, 5245, 14876, 18, 2176, 1977, 5384, 6898, 1942, 3395, 3]}]}
{"query": {"id": "q_5381", "content": "chronic renal failure [SEP] fect of the treatments on renal functional aspects in models of chronic renal failure, and on the mechanism(s) involved.", "tokenized_content": [2, 3724, 4604, 4574, 3, 16688, 1031, 1927, 1920, 4930, 1990, 4604, 3183, 6082, 1922, 3130, 1927, 3724, 4604, 4574, 16, 1930, 1990, 1920, 2856, 12, 61, 13, 3286, 18, 3]}, "items": [{"id": "p_5381", "content": "Kidney Failure, Chronic [SEP] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the l", "score": 1, "type": null, "tokenized_content": [2, 5245, 4574, 16, 3724, 3, 1920, 2482, 17, 3587, 1927, 3724, 4604, 14566, 18, 2176, 1977, 4378, 2007, 1920, 4010, 14104, 5245, 4293, 12, 1966, 3045, 2007, 1920, 54, 3]}]}
{"query": {"id": "q_5382", "content": "Visual hallucinations [SEP] Visual hallucinations associated with zonisamide.", "tokenized_content": [2, 3737, 27013, 3, 3737, 27013, 2458, 1956, 26533, 6509, 16408, 1021, 18, 3]}, "items": [{"id": "p_5382", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_5383", "content": "zonisamide [SEP] Visual hallucinations associated with zonisamide.", "tokenized_content": [2, 26533, 6509, 16408, 1021, 3, 3737, 27013, 2458, 1956, 26533, 6509, 16408, 1021, 18, 3]}, "items": [{"id": "p_5383", "content": "zonisamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26533, 6509, 16408, 1021, 3, 3]}]}
{"query": {"id": "q_5384", "content": "Zonisamide [SEP] Zonisamide is a broad-spectrum antiepileptic drug used to treat various ty", "tokenized_content": [2, 26533, 6509, 16408, 1021, 3, 26533, 6509, 16408, 1021, 1977, 43, 4949, 17, 5648, 29132, 2838, 2251, 1942, 2297, 3425, 6227, 3]}, "items": [{"id": "p_5384", "content": "zonisamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26533, 6509, 16408, 1021, 3, 3]}]}
{"query": {"id": "q_5385", "content": "seizures [SEP] road-spectrum antiepileptic drug used to treat various types of seizures. Although visual hallucinations have not been reported as an ad", "tokenized_content": [2, 10060, 3, 13009, 17, 5648, 29132, 2838, 2251, 1942, 2297, 3425, 3584, 1927, 10060, 18, 2876, 3737, 27013, 2162, 2084, 2252, 2568, 1966, 1925, 2041, 3]}, "items": [{"id": "p_5385", "content": "Seizures [SEP] Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of br", "score": 1, "type": null, "tokenized_content": [2, 10060, 3, 2535, 2014, 16723, 12654, 1927, 5586, 2347, 2810, 1942, 43, 12446, 16, 4552, 16, 9122, 16, 1930, 28252, 7695, 1927, 2387, 3]}]}
{"query": {"id": "q_5386", "content": "visual hallucinations [SEP] pileptic drug used to treat various types of seizures. Although visual hallucinations have not been reported as an adverse effect of this agent, we d", "tokenized_content": [2, 3737, 27013, 3, 7547, 17920, 2838, 2251, 1942, 2297, 3425, 3584, 1927, 10060, 18, 2876, 3737, 27013, 2162, 2084, 2252, 2568, 1966, 1925, 5246, 2495, 1927, 2052, 5899, 16, 2038, 3]}, "items": [{"id": "p_5386", "content": "Hallucinations [SEP] Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real.", "score": 1, "type": null, "tokenized_content": [2, 27013, 3, 9106, 1954, 6090, 26498, 1922, 1920, 3905, 1927, 1925, 4703, 5794, 16, 2308, 2154, 2032, 11067, 2007, 1920, 2725, 1966, 4105, 18, 3]}]}
{"query": {"id": "q_5387", "content": "zonisamide [SEP] d complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased. All three had been", "tokenized_content": [2, 26533, 6509, 16408, 1021, 3, 46, 2796, 3737, 27013, 1930, 5520, 5018, 3642, 2256, 26533, 6509, 16408, 1021, 2311, 1982, 18619, 2014, 2496, 9998, 2502, 18, 2136, 2559, 2430, 2252, 3]}, "items": [{"id": "p_5387", "content": "zonisamide [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 26533, 6509, 16408, 1021, 3, 3]}]}
{"query": {"id": "q_5388", "content": "epilepsy [SEP] its dosage increased. All three had been diagnosed earlier with epilepsy, and their electroencephalogram (EEG) findings were abnormal. D", "tokenized_content": [2, 9741, 3, 2496, 9998, 2502, 18, 2136, 2559, 2430, 2252, 5377, 5556, 1956, 9741, 16, 1930, 2310, 21657, 7539, 12, 9052, 13, 3056, 1985, 4552, 18, 46, 3]}, "items": [{"id": "p_5388", "content": "Epilepsy [SEP] A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuron", "score": 1, "type": null, "tokenized_content": [2, 9741, 3, 43, 4770, 4378, 2007, 7457, 9232, 1927, 28033, 3068, 5273, 2810, 1942, 43, 12446, 16, 4770, 1954, 16, 1930, 9122, 7428, 3]}]}
{"query": {"id": "q_5389", "content": "tyrosine [SEP] GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute pod", "tokenized_content": [2, 6941, 3, 16543, 9434, 1009, 3148, 6941, 8167, 12, 14990, 1931, 13, 1922, 3067, 3797, 7737, 4870, 18, 43, 4966, 1927, 3939, 10181, 3]}, "items": [{"id": "p_5389", "content": "Tyrosine [SEP] A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HO", "score": 1, "type": null, "tokenized_content": [2, 6941, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 1922, 3555, 2176, 1977, 6653, 2037, 17388, 18, 2176, 1977, 2222, 1920, 7897, 1927, 19280, 31, 6918, 6673, 3]}]}
{"query": {"id": "q_5390", "content": "PAN [SEP] GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury.", "tokenized_content": [2, 3797, 3, 16543, 9434, 1009, 3148, 6941, 8167, 12, 14990, 1931, 13, 1922, 3067, 3797, 7737, 4870, 18, 43, 4966, 1927, 3939, 25123, 4047, 18, 3]}, "items": [{"id": "p_5390", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_5391", "content": "nephrosis [SEP] GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury.", "tokenized_content": [2, 7737, 4870, 3, 16543, 9434, 1009, 3148, 6941, 8167, 12, 14990, 1931, 13, 1922, 3067, 3797, 7737, 4870, 18, 43, 4966, 1927, 3939, 25123, 4047, 18, 3]}, "items": [{"id": "p_5391", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_5392", "content": "tyrosine [SEP] lial protein 1 (GLEPP1) is a podocyte receptor membrane protein tyrosine phosphatase located on the apical cell membrane of visceral glo", "tokenized_content": [2, 6941, 3, 25700, 1024, 2213, 21, 12, 16543, 9434, 1009, 13, 1977, 43, 25123, 3148, 3260, 2213, 6941, 8167, 4810, 1990, 1920, 8913, 2024, 3260, 1927, 12708, 25632, 3]}, "items": [{"id": "p_5392", "content": "Tyrosine [SEP] A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HO", "score": 1, "type": null, "tokenized_content": [2, 6941, 3, 43, 2447, 17, 4415, 3835, 2687, 18, 1922, 3555, 2176, 1977, 6653, 2037, 17388, 18, 2176, 1977, 2222, 1920, 7897, 1927, 19280, 31, 6918, 6673, 3]}]}
{"query": {"id": "q_5393", "content": "glomerular injury [SEP] cess. To better understand the utility of GLEPP1 as a marker of glomerular injury, the amount and distribution of GLEPP1 protein and mRNA were ex", "tokenized_content": [2, 11655, 4047, 3, 10897, 18, 1942, 3807, 5734, 1920, 8531, 1927, 16543, 9434, 1009, 1966, 43, 4966, 1927, 11655, 4047, 16, 1920, 4351, 1930, 3282, 1927, 16543, 9434, 1009, 2213, 3]}, "items": [{"id": "p_5393", "content": "Kidney Diseases [SEP] Pathological processes of the KIDNEY or its component tissues.\n    ", "score": 1, "type": null, "tokenized_content": [2, 5245, 3902, 3, 6598, 4028, 1927, 1920, 5245, 2014, 2496, 4594, 3878, 18, 3]}]}
{"query": {"id": "q_5394", "content": "Puromycin aminonucleoside [SEP] Nase protection assay in a model of podocyte injury in the rat. Puromycin aminonucleoside nephrosis was induced by single intraperitoneal injection of pu", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 7312, 1021, 6202, 3381, 1922, 43, 2322, 1927, 25123, 4047, 1922, 1920, 3067, 18, 19750, 3835, 1022, 2626, 8028, 7737, 4870, 1982, 2719, 2007, 3]}, "items": [{"id": "p_5394", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_5395", "content": "nephrosis [SEP]  model of podocyte injury in the rat. Puromycin aminonucleoside nephrosis was induced by single intraperitoneal injection of puromycin am", "tokenized_content": [2, 7737, 4870, 3, 2322, 1927, 25123, 4047, 1922, 1920, 3067, 18, 19750, 3835, 1022, 2626, 8028, 7737, 4870, 1982, 2719, 2007, 2957, 13006, 4107, 1927, 19750, 2150, 3]}, "items": [{"id": "p_5395", "content": "Nephrosis [SEP] Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secon", "score": 1, "type": null, "tokenized_content": [2, 7737, 4870, 3, 6598, 4028, 1927, 1920, 5245, 2979, 3769, 2014, 12847, 4178, 18, 7737, 4870, 2278, 1998, 43, 3065, 4770, 2014, 2532, 1916, 3]}]}
{"query": {"id": "q_5396", "content": "puromycin aminonucleoside [SEP] de nephrosis was induced by single intraperitoneal injection of puromycin aminonucleoside (PAN, 20 mg/100g BW). Tissues were analyzed at 0, 5, 7, 11, 21,", "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 2028, 7737, 4870, 1982, 2719, 2007, 2957, 13006, 4107, 1927, 19750, 3835, 1022, 2626, 8028, 12, 3797, 16, 2036, 2786, 19, 2813, 1029, 11534, 3]}, "items": [{"id": "p_5396", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_5397", "content": "PAN [SEP]  single intraperitoneal injection of puromycin aminonucleoside (PAN, 20 mg/100g BW). Tissues were analyzed at 0, 5, 7, 11, 21, 45, ", "tokenized_content": [2, 3797, 3, 2957, 13006, 4107, 1927, 19750, 3835, 1022, 2626, 8028, 12, 3797, 16, 2036, 2786, 19, 2813, 1029, 11534, 13, 18, 3878, 1985, 3265, 2019, 20, 16, 25, 16, 3]}, "items": [{"id": "p_5397", "content": "Puromycin Aminonucleoside [SEP] PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineopl", "score": 1, "type": null, "tokenized_content": [2, 19750, 3835, 1022, 2626, 8028, 3, 19750, 10533, 1988, 13012, 1920, 17954, 17616, 2199, 8056, 16323, 1024, 2210, 1990, 1920, 13610, 1927, 1920, 9523, 6335, 18, 2176, 1977, 1925, 7267, 1956, 29128, 3513, 3]}]}
{"query": {"id": "q_5398", "content": "proteinuria [SEP] ys after PAN injection so as to include both the acute phase of proteinuria associated with foot process effacement (days 5-11) and the chr", "tokenized_content": [2, 15831, 3, 24018, 2256, 3797, 4107, 2577, 1966, 1942, 3951, 2321, 1920, 3939, 3193, 1927, 15831, 2458, 1956, 8135, 2585, 2121, 2431, 2017, 12, 3000, 25, 17, 2513, 13, 1930, 3]}, "items": [{"id": "p_5398", "content": "Proteinuria [SEP] The presence of proteins in the urine, an indicator of KIDNEY DISEASES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 15831, 3, 1920, 2990, 1927, 2697, 1922, 1920, 6960, 16, 1925, 8413, 1927, 5245, 3902, 18, 3]}]}
{"query": {"id": "q_5399", "content": "glomerulosclerosis [SEP] days 5-11) and the chronic phase of proteinuria associated with glomerulosclerosis (days 45-126). At day 5, GLEPP1 protein and mRNA were reduced f", "tokenized_content": [2, 19268, 25081, 3, 3000, 25, 17, 2513, 13, 1930, 1920, 3724, 3193, 1927, 15831, 2458, 1956, 19268, 25081, 12, 3000, 3607, 17, 10483, 13, 18, 2019, 3007, 25, 16, 16543, 3]}, "items": [{"id": "p_5399", "content": "Glomerulonephritis [SEP] Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including anti", "score": 1, "type": null, "tokenized_content": [2, 27057, 3, 4531, 1927, 1920, 4604, 20276, 12, 5245, 19268, 1957, 13, 1988, 2112, 1998, 5947, 2007, 1920, 2601, 1927, 11655, 8209, 2710, 2246, 3]}]}
{"query": {"id": "q_5400", "content": "Ticlopidine [SEP] Ticlopidine-induced aplastic anemia: report of three Chinese patients and r", "tokenized_content": [2, 18298, 6012, 10984, 27099, 3, 18298, 6012, 10984, 27099, 17, 2719, 18373, 4054, 10679, 30, 3809, 1927, 2559, 7185, 2132, 1930, 60, 3]}, "items": [{"id": "p_5400", "content": "Ticlopidine [SEP] An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18298, 6012, 10984, 27099, 3, 1925, 3655, 4106, 1927, 7163, 7883, 5384, 2251, 1922, 1920, 9555, 1927, 18478, 1922, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_5401", "content": "aplastic anemia [SEP] Ticlopidine-induced aplastic anemia: report of three Chinese patients and review of the literature.", "tokenized_content": [2, 18373, 4054, 10679, 3, 18298, 6012, 10984, 27099, 17, 2719, 18373, 4054, 10679, 30, 3809, 1927, 2559, 7185, 2132, 1930, 3043, 1927, 1920, 4431, 18, 3]}, "items": [{"id": "p_5401", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_5402", "content": "ticlopidine [SEP] In this study, three Chinese patients with ticlopidine-induced aplastic anemia were reported and another 13 patients i", "tokenized_content": [2, 18298, 6012, 10984, 27099, 3, 1922, 2052, 2161, 16, 2559, 7185, 2132, 1956, 18298, 6012, 10984, 27099, 17, 2719, 18373, 4054, 10679, 1985, 2568, 1930, 3741, 2590, 2132, 51, 3]}, "items": [{"id": "p_5402", "content": "Ticlopidine [SEP] An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18298, 6012, 10984, 27099, 3, 1925, 3655, 4106, 1927, 7163, 7883, 5384, 2251, 1922, 1920, 9555, 1927, 18478, 1922, 5846, 9345, 18, 3]}]}
{"query": {"id": "q_5403", "content": "aplastic anemia [SEP] In this study, three Chinese patients with ticlopidine-induced aplastic anemia were reported and another 13 patients in the English literature", "tokenized_content": [2, 18373, 4054, 10679, 3, 1922, 2052, 2161, 16, 2559, 7185, 2132, 1956, 18298, 6012, 10984, 27099, 17, 2719, 18373, 4054, 10679, 1985, 2568, 1930, 3741, 2590, 2132, 1922, 1920, 8998, 3]}, "items": [{"id": "p_5403", "content": "Anemia, Aplastic [SEP] A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\n    ", "score": 1, "type": null, "tokenized_content": [2, 10679, 16, 18373, 4054, 3, 43, 2386, 1927, 10679, 1922, 2154, 1920, 3622, 6599, 16300, 1942, 5074, 7485, 4630, 1927, 5009, 2877, 5362, 18, 3]}]}
{"query": {"id": "q_5404", "content": "Agranulocytosis [SEP]  old age may be a risk factor for developing this complication. Agranulocytosis occurred 3-20 weeks after initiation of ticlopidine, so frequen", "tokenized_content": [2, 23171, 1928, 1944, 7349, 3, 4156, 2632, 2278, 1998, 43, 2565, 2991, 1958, 5130, 2052, 9388, 18, 23171, 1928, 1944, 7349, 4807, 23, 17, 2036, 3625, 2256, 6035, 1927, 18298, 3]}, "items": [{"id": "p_5404", "content": "Agranulocytosis [SEP] A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).\n    ", "score": 1, "type": null, "tokenized_content": [2, 23171, 1928, 1944, 7349, 3, 43, 3714, 1922, 1920, 2529, 1927, 22144, 31, 12, 29929, 31, 15854, 31, 1930, 8508, 13, 18, 3]}]}
{"query": {"id": "q_5405", "content": "bone marrow suppression [SEP] rrelation between the dose or duration used and the severity of bone marrow suppression. Treatment for ticlopidine-induced aplastic anemia with colony-", "tokenized_content": [2, 3622, 6599, 6412, 3, 5162, 15208, 1929, 2192, 1920, 3253, 2014, 4392, 2251, 1930, 1920, 5155, 1927, 3622, 6599, 6412, 18, 2311, 1958, 18298, 6012, 10984, 27099, 17, 2719, 18373, 3]}, "items": [{"id": "p_5405", "content": "Bone Marrow Diseases [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 3622, 6599, 3902, 3, 3]}]}
{"query": {"id": "q_5406", "content": "calcium [SEP] fect. The fact that 5 of the 6 patients who received concurrent calcium channel blockers died, should alert clinicians to be more cauti", "tokenized_content": [2, 5016, 3, 16688, 1031, 18, 1920, 2371, 1988, 25, 1927, 1920, 26, 2132, 2746, 4004, 10391, 5016, 4999, 13628, 8545, 16, 3066, 18635, 8575, 1942, 1998, 2253, 20200, 1914, 3]}, "items": [{"id": "p_5406", "content": "Calcium [SEP] A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic sym", "score": 1, "type": null, "tokenized_content": [2, 5016, 3, 43, 5937, 6149, 2435, 1922, 6737, 2136, 11275, 3878, 18, 2176, 1977, 43, 7210, 1927, 1920, 10746, 13151, 3416, 1927, 11570, 1956, 1920, 11241, 2985, 3]}]}
{"query": {"id": "q_5407", "content": "morphine [SEP] Facilitation of memory retrieval by pre-test morphine and its state dependency in the step-through type passive avoid", "tokenized_content": [2, 11553, 3, 17477, 1927, 4525, 10881, 2007, 2097, 17, 2648, 11553, 1930, 2496, 3360, 14604, 1922, 1920, 3537, 17, 2596, 2601, 9832, 5161, 3]}, "items": [{"id": "p_5407", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_5408", "content": "Amnesia [SEP] Amnesia produced by scopolamine and cycloheximide were reversed by morp", "tokenized_content": [2, 14701, 7156, 3, 14701, 7156, 4152, 2007, 25392, 10173, 25157, 1930, 21279, 1985, 9432, 2007, 2803, 1034, 3]}, "items": [{"id": "p_5408", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_5409", "content": "scopolamine [SEP] Amnesia produced by scopolamine and cycloheximide were reversed by morphine given 30 min before", "tokenized_content": [2, 25392, 10173, 25157, 3, 14701, 7156, 4152, 2007, 25392, 10173, 25157, 1930, 21279, 1985, 9432, 2007, 11553, 3258, 2627, 2360, 3119, 3]}, "items": [{"id": "p_5409", "content": "Scopolamine Hydrobromide [SEP] An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics l", "score": 1, "type": null, "tokenized_content": [2, 25392, 10173, 25157, 3290, 18474, 16408, 1021, 3, 1925, 29951, 2037, 2638, 7241, 1972, 3336, 16, 4369, 2181, 9280, 1930, 25392, 18676, 18, 25392, 10173, 25157, 1930, 2496, 21920, 8383, 4033, 1966, 20330, 7801, 18979, 1036, 54, 3]}]}
{"query": {"id": "q_5410", "content": "cycloheximide [SEP] Amnesia produced by scopolamine and cycloheximide were reversed by morphine given 30 min before the test trial (p", "tokenized_content": [2, 21279, 3, 14701, 7156, 4152, 2007, 25392, 10173, 25157, 1930, 21279, 1985, 9432, 2007, 11553, 3258, 2627, 2360, 3119, 1920, 2648, 3046, 12, 58, 3]}, "items": [{"id": "p_5410", "content": "Cycloheximide [SEP] Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation duri", "score": 1, "type": null, "tokenized_content": [2, 21279, 3, 7267, 7311, 3937, 2037, 10666, 17, 7144, 4046, 1927, 22874, 2398, 2870, 1957, 18, 2176, 8016, 2007, 7918, 9971, 2335, 1033, 3]}]}
{"query": {"id": "q_5411", "content": "morphine [SEP] esia produced by scopolamine and cycloheximide were reversed by morphine given 30 min before the test trial (pre-test), and pre-test mor", "tokenized_content": [2, 11553, 3, 11575, 1019, 4152, 2007, 25392, 10173, 25157, 1930, 21279, 1985, 9432, 2007, 11553, 3258, 2627, 2360, 3119, 1920, 2648, 3046, 12, 2097, 17, 2648, 13, 16, 1930, 2097, 3]}, "items": [{"id": "p_5411", "content": "Morphine [SEP] The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central ", "score": 1, "type": null, "tokenized_content": [2, 11553, 3, 1920, 7944, 29951, 1922, 7976, 1989, 1930, 1920, 17058, 27059, 14501, 1930, 22872, 3153, 18, 11553, 2258, 9360, 2564, 1922, 1920, 4101, 3]}]}
{"query": {"id": "q_5412", "content": "naloxone [SEP] so facilitated the memory retrieval in the animals administered naloxone during the training trial. Similarly, pre-test scopolamine part", "tokenized_content": [2, 21926, 3, 2577, 11556, 1920, 4525, 10881, 1922, 1920, 3555, 5254, 21926, 2409, 1920, 4096, 3046, 18, 4852, 16, 2097, 17, 2648, 25392, 10173, 25157, 3131, 3]}, "items": [{"id": "p_5412", "content": "Naloxone [SEP] A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid recepto", "score": 1, "type": null, "tokenized_content": [2, 21926, 3, 43, 2487, 27059, 8151, 1988, 2258, 2239, 7829, 2455, 18, 2176, 1977, 43, 10362, 8151, 2019, 8975, 16, 9649, 16, 1930, 12093, 9384, 2793, 4575, 3]}]}
{"query": {"id": "q_5413", "content": "amnesia [SEP] pre-test scopolamine partially reversed the scopolamine-induced amnesia, but not significantly; and pre-test cycloheximide failed to re", "tokenized_content": [2, 14701, 7156, 3, 2097, 17, 2648, 25392, 10173, 25157, 6426, 9432, 1920, 25392, 10173, 25157, 17, 2719, 14701, 7156, 16, 2308, 2084, 2567, 31, 1930, 2097, 17, 2648, 21279, 6617, 3]}, "items": [{"id": "p_5413", "content": "Amnesia [SEP] Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMN", "score": 1, "type": null, "tokenized_content": [2, 14701, 7156, 3, 11896, 5740, 2014, 4080, 3257, 1927, 1920, 3682, 1942, 8717, 5375, 7651, 12, 14701, 7156, 16, 14492, 13, 2014, 1942, 2386, 2814, 17921, 12, 14701, 3]}]}
{"query": {"id": "q_5414", "content": "Apomorphine [SEP] induced behavioral and neurophysiological responses in rodents. Apomorphine, a nonselective dopamine agonist, was selected due to its bipha", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 2719, 5343, 1930, 23952, 3387, 1922, 12035, 18, 11466, 12492, 11119, 7969, 2912, 16, 43, 6771, 25568, 7964, 7829, 16, 1982, 3790, 2810, 1942, 3]}, "items": [{"id": "p_5414", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_5415", "content": "dopamine agonist [SEP] physiological responses in rodents. Apomorphine, a nonselective dopamine agonist, was selected due to its biphasic behavioral effects, its abili", "tokenized_content": [2, 7964, 7829, 3, 5005, 3387, 1922, 12035, 18, 11466, 12492, 11119, 7969, 2912, 16, 43, 6771, 25568, 7964, 7829, 16, 1982, 3790, 2810, 1942, 2496, 18243, 5343, 2564, 16, 2496, 3]}, "items": [{"id": "p_5415", "content": "Dopamine Agonists [SEP] Drugs that bind to and activate dopamine receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7964, 9849, 3, 4195, 1988, 4566, 1942, 1930, 6980, 7964, 4086, 18, 3]}]}
{"query": {"id": "q_5416", "content": "hypothermia [SEP] d due to its biphasic behavioral effects, its ability to induce hypothermia, and to produce distinct changes to dopamine turnover in the ro", "tokenized_content": [2, 18750, 3, 46, 2810, 1942, 2496, 18243, 5343, 2564, 16, 2496, 3682, 1942, 4769, 18750, 16, 1930, 1942, 5074, 4493, 2840, 1942, 7964, 9781, 1922, 1920, 3039, 3]}, "items": [{"id": "p_5416", "content": "Hypothermia [SEP] Lower than normal body temperature, especially in warm-blooded animals.\n    ", "score": 1, "type": null, "tokenized_content": [2, 18750, 3, 2826, 2254, 2791, 3362, 3449, 16, 4369, 1922, 10142, 17, 2877, 1919, 3555, 18, 3]}]}
{"query": {"id": "q_5417", "content": "dopamine [SEP] physiological responses in rodents. Apomorphine, a nonselective dopamine agonist, was selected due to its biphasic behavioral effects, i", "tokenized_content": [2, 7964, 3, 5005, 3387, 1922, 12035, 18, 11466, 12492, 11119, 7969, 2912, 16, 43, 6771, 25568, 7964, 7829, 16, 1982, 3790, 2810, 1942, 2496, 18243, 5343, 2564, 16, 51, 3]}, "items": [{"id": "p_5417", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_5418", "content": "apomorphine [SEP] iments there is evidence that characterization and detection of apomorphine-induced activity in rodents critically depends upon the test co", "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 2042, 2039, 2276, 1977, 3095, 1988, 7285, 1930, 3805, 1927, 11466, 12492, 11119, 7969, 2912, 17, 2719, 2455, 1922, 12035, 9790, 7315, 4073, 1920, 3]}, "items": [{"id": "p_5418", "content": "Apomorphine [SEP] A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poiso", "score": 1, "type": null, "tokenized_content": [2, 11466, 12492, 11119, 7969, 2912, 3, 43, 10533, 1927, 11553, 1988, 1977, 43, 7964, 8631, 7829, 18, 2176, 1977, 43, 9974, 2391, 3023, 1930, 2258, 2252, 2251, 1958, 1988, 2495, 1922, 3939, 2510, 23854, 3]}]}
{"query": {"id": "q_5419", "content": "hyperactivity [SEP]  conditions employed. In rats, detection of apomorphine-induced hyperactivity was facilitated by a period of acclimatization to the test cond", "tokenized_content": [2, 15534, 3, 2961, 5789, 18, 1922, 3615, 16, 3805, 1927, 11466, 12492, 11119, 7969, 2912, 17, 2719, 15534, 1982, 11556, 2007, 43, 3047, 1927, 16016, 17316, 1942, 1920, 2648, 8646, 3]}, "items": [{"id": "p_5419", "content": "Hyperkinesis [SEP] Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.\n    ", "score": 1, "type": null, "tokenized_content": [2, 4194, 23786, 1937, 3, 9122, 5829, 1927, 7848, 1927, 1920, 3362, 1966, 43, 4292, 16, 2154, 2278, 1998, 2458, 1956, 6805, 2014, 6674, 4414, 18, 3]}]}
{"query": {"id": "q_5420", "content": "Dopamine [SEP] ced locomotion was more prominent in the novel exploratory box. Dopamine turnover ratios (DOPAC:DA and HVA:DA) were found to be lower in", "tokenized_content": [2, 7964, 3, 19424, 16929, 1982, 2253, 8753, 1922, 1920, 4008, 12733, 5758, 18, 7964, 9781, 5835, 12, 19428, 1030, 30, 3692, 1930, 12948, 1019, 30, 3692, 13, 1985, 2435, 1942, 3]}, "items": [{"id": "p_5420", "content": "Dopamine [SEP] One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and ", "score": 1, "type": null, "tokenized_content": [2, 7964, 3, 2340, 1927, 1920, 23483, 21012, 1922, 1920, 3068, 18, 2176, 1977, 3595, 2037, 6941, 1930, 1977, 1920, 7897, 1942, 16436, 1930, 3]}]}
{"query": {"id": "q_5421", "content": "DOPAC [SEP] ominent in the novel exploratory box. Dopamine turnover ratios (DOPAC:DA and HVA:DA) were found to be lower in those animals exposed ", "tokenized_content": [2, 19428, 1030, 3, 7254, 2053, 4905, 1922, 1920, 4008, 12733, 5758, 18, 7964, 9781, 5835, 12, 19428, 1030, 30, 3692, 1930, 12948, 1019, 30, 3692, 13, 1985, 2435, 1942, 1998, 3]}, "items": [{"id": "p_5421", "content": "3,4-Dihydroxyphenylacetic Acid [SEP] A deaminated metabolite of LEVODOPA.\n    ", "score": 1, "type": null, "tokenized_content": [2, 23, 16, 24, 17, 20684, 17616, 2199, 13722, 2687, 3, 43, 30097, 8547, 1981, 9483, 1927, 26723, 18, 3]}]}
{"query": {"id": "q_5422", "content": "DA [SEP] t in the novel exploratory box. Dopamine turnover ratios (DOPAC:DA and HVA:DA) were found to be lower in those animals exposed to ", "tokenized_content": [2, 3692, 3, 62, 1922, 1920, 4008, 12733, 5758, 18, 7964, 9781, 5835, 12, 19428, 1030, 30, 3692, 1930, 12948, 1019, 30, 3692, 13, 1985, 2435, 1942, 1998, 2826, 1922, 2690, 3]}, "items": [{"id": "p_5422", "content": "Dopamine Agonists [SEP] Drugs that bind to and activate dopamine receptors.\n    ", "score": 1, "type": null, "tokenized_content": [2, 7964, 9849, 3, 4195, 1988, 4566, 1942, 1930, 6980, 7964, 4086, 18, 3]}]}
{"query": {"id": "q_5423", "content": "HVA [SEP] e novel exploratory box. Dopamine turnover ratios (DOPAC:DA and HVA:DA) were found to be lower in those animals exposed to the expl", "tokenized_content": [2, 12948, 1019, 3, 47, 4008, 12733, 5758, 18, 7964, 9781, 5835, 12, 19428, 1030, 30, 3692, 1930, 12948, 1019, 30, 3692, 13, 1985, 2435, 1942, 1998, 2826, 1922, 2690, 3555, 3]}, "items": [{"id": "p_5423", "content": "Homovanillic Acid [SEP] ", "score": 1, "type": null, "tokenized_content": [2, 16350, 25777, 13382, 1030, 2687, 3, 3]}]}