LiteFold/GO · Datasets at Hugging Face

GO:0000002

2

obsolete mitochondrial genome maintenance

biological_process

OBSOLETE. The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.

[ "GOC:ai", "GOC:vw" ]

This term described phenotypic observations for multiple processes (including transport/lipid metabolism/ DNA metabolism/ fission/ fusion etc)

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29646\" xsd:anyURI" ]

null

true

6

GO:0000003

3

obsolete reproduction

biological_process

OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.

[ "GOC:curators", "GOC:isa_complete", "GOC:jl", "ISBN:0198506732" ]

The reason for obsoletion is that this term is equivalent to reproductive process.

[ "reproductive physiological process" ]

[ "EXACT" ]

[]

[ "GO:0022414" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27054\" xsd:anyURI" ]

null

true

7

GO:0000006

6

high-affinity zinc transmembrane transporter activity

molecular_function

Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.

[ "TC:2.A.5.1.1" ]

null

[ "high affinity zinc uptake transmembrane transporter activity", "high-affinity zinc uptake transmembrane transporter activity" ]

[ "EXACT", "RELATED" ]

[]

[ "GO:0005385" ]

[]

[ "GO:0005385" ]

[]

null

false

true

7

GO:0000007

7

low-affinity zinc ion transmembrane transporter activity

molecular_function

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.

[ "GOC:mtg_transport", "ISBN:0815340729" ]

null

[]

[ "GO:0005385" ]

[]

[ "GO:0005385" ]

[]

null

false

true

3

GO:0000008

8

obsolete thioredoxin

molecular_function

OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net re...

[ "GOC:kd" ]

This term was made obsolete because it represents gene products.

[ "thioredoxin" ]

[ "EXACT" ]

[ "GO:0000013" ]

[]

[ "GO:0003756", "GO:0015036" ]

[]

null

true

6

GO:0000009

9

alpha-1,6-mannosyltransferase activity

molecular_function

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage.

[ "GOC:mcc", "PMID:2644248" ]

null

[ "1,6-alpha-mannosyltransferase activity" ]

[ "EXACT" ]

[]

[ "Reactome:R-HSA-449718 \"Addition of a third mannose to the N-glycan precursor by ALG2\"" ]

[ "GO:0000030" ]

[]

[ "GO:0000030" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19075\" xsd:anyURI" ]

null

false

true

7

GO:0000010

10

heptaprenyl diphosphate synthase activity

molecular_function

Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

[ "PMID:9708911", "RHEA:27794" ]

null

[ "all-trans-heptaprenyl-diphosphate synthase activity", "HepPP synthase activity", "heptaprenyl pyrophosphate synthase activity", "heptaprenyl pyrophosphate synthetase activity", "trans-hexaprenyltranstransferase activity" ]

[ "EXACT", "RELATED", "RELATED", "RELATED", "EXACT" ]

[ "GO:0036422" ]

[]

[ "EC:2.5.1.30", "MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN", "RHEA:27794" ]

[ "GO:0120531" ]

[]

[ "GO:0120531" ]

[]

[ "skos:exactMatch EC:2.5.1.30", "skos:exactMatch RHEA:27794", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20661\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23472\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontol...

bf

2013-09-16T11:50:41Z

false

true

7

GO:0000011

11

vacuole inheritance

biological_process

The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.

[ "GOC:mcc", "PMID:10873824", "PMID:14616069" ]

null

[]

[ "GO:0007033", "GO:0048308" ]

[]

[ "GO:0007033", "GO:0048308" ]

[]

null

false

true

3

GO:0000012

12

single strand break repair

biological_process

The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.

[ "PMID:18626472" ]

null

[]

[ "GO:0006281" ]

[]

[ "GO:0006281" ]

[]

null

false

true

6

GO:0000014

14

single-stranded DNA endonuclease activity

molecular_function

Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.

[ "GOC:mah" ]

null

[ "single-stranded DNA endodeoxyribonuclease activity", "single-stranded DNA specific endodeoxyribonuclease activity", "ssDNA-specific endodeoxyribonuclease activity" ]

[ "EXACT", "RELATED", "RELATED" ]

[]

[ "GO:0004520", "GO:0016788" ]

[]

[ "GO:0004520", "GO:0016788" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24408\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31721\" xsd:anyURI" ]

null

false

true

9

GO:0000015

15

phosphopyruvate hydratase complex

cellular_component

A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.

[ "GOC:jl", "ISBN:0198506732" ]

null

[ "enolase complex" ]

[ "EXACT" ]

[]

[ "goslim_metagenomics" ]

[]

[ "GO:1902494" ]

[ "part_of GO:0005829" ]

[ "part_of" ]

[ "GO:0005829" ]

[ "GO:0005829", "GO:1902494" ]

[]

null

false

true

6

GO:0000016

16

lactase activity

molecular_function

Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.

[ "PMID:12023280" ]

null

[ "lactose galactohydrolase activity" ]

[ "EXACT" ]

[]

[ "EC:3.2.1.108", "MetaCyc:BETAGALACTOSID-RXN", "Reactome:R-HSA-189062 \"lactose + H2O => D-glucose + D-galactose\"", "Reactome:R-HSA-5658001 \"Defective LCT does not hydrolyze Lac\"", "RHEA:10076", "RHEA:28659" ]

[ "GO:0004553" ]

[]

[ "GO:0004553" ]

[]

[ "skos:exactMatch EC:3.2.1.108", "skos:exactMatch RHEA:10076", "skos:narrowMatch RHEA:28659", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0000017

17

alpha-glucoside transport

biological_process

The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration.

[ "GOC:jl", "ISBN:0198506732", "PMID:9919658" ]

null

[]

[ "GO:0042946" ]

[]

[ "GO:0042946" ]

[]

null

false

true

6

GO:0000018

18

regulation of DNA recombination

biological_process

Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.

[ "GOC:curators", "ISBN:0198506732" ]

null

[]

[ "GO:0051052" ]

[ "regulates GO:0006310" ]

[ "regulates" ]

[ "GO:0006310" ]

[ "GO:0006310", "GO:0051052" ]

[ "GO:0065007", "regulates GO:0006310" ]

[]

null

false

true

5

GO:0000019

19

regulation of mitotic recombination

biological_process

Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.

[ "GOC:curators" ]

null

[ "regulation of recombination within rDNA repeats" ]

[ "NARROW" ]

[]

[ "GO:0000018" ]

[ "regulates GO:0006312" ]

[ "regulates" ]

[ "GO:0006312" ]

[ "GO:0000018", "GO:0006312" ]

[ "GO:0065007", "regulates GO:0006312" ]

[]

null

false

true

2

GO:0000020

20

obsolete negative regulation of recombination within rDNA repeats

biological_process

OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.

[ "GOC:curators", "ISBN:0198506732" ]

This term was made obsolete because it describes a substrate-specific process.

[ "negative regulation of recombination within rDNA repeats" ]

[ "EXACT" ]

[]

[ "GO:0045950" ]

[]

null

true

2

GO:0000022

22

mitotic spindle elongation

biological_process

The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B.

[ "GOC:mtg_cell_cycle", "GOC:vw", "PMID:19686686" ]

null

[ "microtubule sliding involved in mitotic spindle elongation", "spindle elongation during mitosis" ]

[ "RELATED", "EXACT" ]

[ "GO:1905121" ]

[]

[ "GO:0051231", "GO:1903047" ]

[ "part_of GO:0000070", "part_of GO:0007052" ]

[ "part_of", "part_of" ]

[ "GO:0000070", "GO:0007052" ]

[ "GO:0000070", "GO:0007052", "GO:0051231", "GO:1903047" ]

[ "GO:0051231", "part_of GO:0000278" ]

[]

pr

2016-04-08T15:06:14Z

false

true

7

GO:0000023

23

maltose metabolic process

biological_process

The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch.

[ "GOC:jl", "ISBN:0198506732" ]

null

[ "malt sugar metabolic process", "malt sugar metabolism", "maltose metabolism" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0005984" ]

[]

[ "GO:0005984" ]

[]

null

false

true

2

GO:0000024

24

maltose biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).

[ "GOC:jl", "ISBN:0198506732" ]

null

[ "malt sugar biosynthesis", "malt sugar biosynthetic process", "maltose anabolism", "maltose biosynthesis", "maltose formation", "maltose synthesis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0000023", "GO:0046351" ]

[]

[ "GO:0000023", "GO:0046351" ]

[]

null

false

true

4

GO:0000025

25

maltose catabolic process

biological_process

The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).

[ "GOC:jl", "ISBN:0198506732" ]

null

[ "malt sugar catabolic process", "malt sugar catabolism", "maltose breakdown", "maltose degradation", "maltose hydrolysis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "NARROW" ]

[]

[ "MetaCyc:MALTOSECAT-PWY" ]

[ "GO:0000023", "GO:0046352" ]

[]

[ "GO:0000023", "GO:0046352" ]

[]

null

false

true

1

GO:0000026

26

alpha-1,2-mannosyltransferase activity

molecular_function

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.

[ "GOC:mcc", "PMID:10521541" ]

null

[]

[ "Reactome:R-HSA-446187 \"ALG11 transfers the fourth and fifth Man to the N-glycan precursor\"", "Reactome:R-HSA-446215 \"ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1\"", "Reactome:R-HSA-446216 \"ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1\"", "Reactome:R-HSA-4551...

[ "GO:0000030" ]

[]

[ "GO:0000030" ]

[]

null

false

true

7

GO:0000027

27

ribosomal large subunit assembly

biological_process

The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.

[ "GOC:jl", "PMID:30467428" ]

null

[ "50S ribosomal subunit assembly", "60S ribosomal subunit assembly" ]

[ "NARROW", "NARROW" ]

[]

[ "GO:0022618" ]

[ "part_of GO:0042255", "part_of GO:0042273" ]

[ "part_of", "part_of" ]

[ "GO:0042255", "GO:0042273" ]

[ "GO:0022618", "GO:0042255", "GO:0042273" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23886\" xsd:anyURI" ]

null

false

true

8

GO:0000028

28

ribosomal small subunit assembly

biological_process

The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.

[ "GOC:jl", "PMID:30467428" ]

null

[ "30S ribosomal subunit assembly", "40S ribosomal subunit assembly" ]

[ "NARROW", "NARROW" ]

[]

[ "GO:0022618" ]

[ "part_of GO:0042255", "part_of GO:0042274" ]

[ "part_of", "part_of" ]

[ "GO:0042255", "GO:0042274" ]

[ "GO:0022618", "GO:0042255", "GO:0042274" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23886\" xsd:anyURI" ]

null

false

true

5

GO:0000030

30

mannosyltransferase activity

molecular_function

Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

[ "GOC:ai", "GOC:cjm" ]

null

[]

[ "Reactome:R-HSA-162797 \"mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI\"", "Reactome:R-HSA-162830 \"glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminy...

[ "GO:0016758" ]

[]

[ "GO:0016758" ]

[]

null

false

true

2

GO:0000031

31

mannosylphosphate transferase activity

molecular_function

Catalysis of the reaction: GDP-alpha-D-mannose + n {[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]-alpha-D-Man-(1->6)}60-(Man9GlcNAc2-[protein] = phosphorylated {[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]-alpha-D-Man-(1->6)}60-(Man9GlcNAc2-[protein] + n GMP + n H+ or GDP-alpha-D-mannose + alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-al...

[ "MetaCyc:RXN-22693", "MetaCyc:RXN-22694" ]

null

[]

[ "MetaCyc:RXN-22693", "MetaCyc:RXN-22694" ]

[ "GO:0016758" ]

[]

[ "GO:0016758" ]

[]

[ "skos:narrowMatch MetaCyc:RXN-22693", "skos:narrowMatch MetaCyc:RXN-22694", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28340\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28811\" xsd:anyURI" ]

null

false

true

2

GO:0000032

32

cell wall mannoprotein biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.

[ "GOC:ai" ]

null

[ "cell wall mannoprotein anabolism", "cell wall mannoprotein biosynthesis", "cell wall mannoprotein formation", "cell wall mannoprotein synthesis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0031506" ]

[]

[ "GO:0031506" ]

[]

null

false

true

3

GO:0000033

33

alpha-1,3-mannosyltransferase activity

molecular_function

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.

[ "GOC:mcc", "PMID:10521541" ]

null

[]

[ "Reactome:R-HSA-446188 \"ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1\"", "Reactome:R-HSA-446208 \"Addition of a second mannose to the N-glycan precursor by ALG2\"", "Reactome:R-HSA-4549368 \"Defective ALG2 does not transfer a second Man to N-glycan precursor\"", "Reactome:R-HSA-4720473...

[ "GO:0000030" ]

[]

[ "GO:0000030" ]

[]

null

false

true

1

GO:0000035

35

acyl binding

molecular_function

Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.

[ "GOC:curators", "ISBN:0198506732" ]

null

[ "acyl-CoA or acyl binding" ]

[ "BROAD" ]

[]

[ "GO:0036094" ]

[]

[ "GO:0036094" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21211\" xsd:anyURI" ]

null

false

true

8

GO:0000036

36

acyl carrier activity

molecular_function

Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in ...

[ "GOC:jl", "GOC:vw" ]

null

[ "ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process" ]

[ "EXACT" ]

[]

[ "GO:0044620", "GO:0140414" ]

[ "part_of GO:0006633" ]

[ "part_of" ]

[ "GO:0006633" ]

[ "GO:0006633", "GO:0044620", "GO:0140414" ]

[ "GO:0140414", "part_of GO:0006633" ]

[]

null

false

true

7

GO:0000038

38

very long-chain fatty acid metabolic process

biological_process

The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.

[ "GOC:hjd" ]

While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

[ "very long chain fatty acid metabolic process", "very-long-chain fatty acid metabolic process", "very-long-chain fatty acid metabolism" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0006631" ]

[]

[ "GO:0006631" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26445\" xsd:anyURI" ]

null

false

true

8

GO:0000039

39

obsolete plasma membrane long-chain fatty acid transporter

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it describes a gene product and it contains component information.

[ "plasma membrane long-chain fatty acid transporter" ]

[ "EXACT" ]

[]

[ "GO:0005324", "GO:0005886" ]

[]

null

true

3

GO:0000041

41

transition metal ion transport

biological_process

The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshe...

[ "ISBN:0198506732" ]

null

[ "transition metal transport" ]

[ "EXACT" ]

[]

[ "GO:0030001" ]

[]

[ "GO:0030001" ]

[]

null

false

true

8

GO:0000044

44

obsolete ascorbate stabilization

biological_process

OBSOLETE. The reduction of the ascorbate free radical to a stable form.

[ "GOC:ai", "GOC:mtg_electron_transport" ]

This term was made obsolete because it is defined as a function term and is in the process ontology.

[ "ascorbate stabilization", "vitamin C stabilization" ]

[ "EXACT", "EXACT" ]

[]

null

true

3

GO:0000045

45

autophagosome assembly

biological_process

The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.

[ "GOC:autophagy", "PMID:9412464" ]

null

[ "autophagic vacuole assembly", "autophagic vacuole formation", "autophagosome biosynthesis", "autophagosome formation", "PAS formation" ]

[ "EXACT", "RELATED", "EXACT", "EXACT", "NARROW" ]

[]

[ "GO:0070925", "GO:1905037" ]

[ "has_part GO:0019778", "has_part GO:0019786", "has_part GO:0061651", "has_part GO:0061660", "has_part GO:1904745" ]

[ "has_part", "has_part", "has_part", "has_part", "has_part" ]

[ "GO:0019778", "GO:0019786", "GO:0061651", "GO:0061660", "GO:1904745" ]

[ "GO:0019778", "GO:0019786", "GO:0061651", "GO:0061660", "GO:0070925", "GO:1904745", "GO:1905037" ]

[]

null

false

true

3

GO:0000047

47

obsolete Rieske iron-sulfur protein

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it represents a gene product.

[ "Rieske iron-sulfur protein", "Rieske iron-sulphur protein" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0009055" ]

[]

null

true

1

GO:0000048

48

peptidyltransferase activity

molecular_function

Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme.

[ "EC:2.3.2.12", "PMID:11433365", "PMID:9242921" ]

null

[]

[ "EC:2.3.2.12", "MetaCyc:PEPTIDYLTRANSFERASE-RXN", "Reactome:R-HSA-156912 \"Peptide transfer from P-site tRNA to the A-site tRNA\"" ]

[ "GO:0016755", "GO:0140096", "GO:0140101" ]

[]

[ "GO:0016755", "GO:0140096", "GO:0140101" ]

[]

[ "skos:exactMatch EC:2.3.2.12", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22192\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25493\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0000049

49

tRNA binding

molecular_function

Binding to a transfer RNA.

[ "GOC:ai" ]

null

[ "base pairing with tRNA" ]

[ "NARROW" ]

[ "GO:0000946" ]

[]

[ "Reactome:R-HSA-2408509 \"Sec-tRNA(Sec) binds to EEFSEC:GTP\"" ]

[ "GO:0003723" ]

[]

[ "GO:0003723" ]

[]

null

false

true

9

GO:0000051

51

obsolete urea cycle intermediate metabolic process

biological_process

OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.

[ "GOC:jl", "ISBN:0198506732" ]

This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations.

[ "urea cycle intermediate metabolic process", "urea cycle intermediate metabolism" ]

[ "EXACT", "EXACT" ]

[]

null

true

9

GO:0000052

52

citrulline metabolic process

biological_process

The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.

[ "ISBN:0198506732" ]

null

[ "citrulline metabolism" ]

[ "EXACT" ]

[]

[ "GO:0170041", "GO:1901605" ]

[]

[ "GO:0170041", "GO:1901605" ]

[]

null

false

true

5

GO:0000053

53

obsolete argininosuccinate metabolic process

biological_process

OBSOLETE. The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate.

[ "ISBN:0198506732" ]

This term was obsoleted because it represents a pathway intermediate.

[ "argininosuccinate metabolism" ]

[ "EXACT" ]

[]

[ "GO:0000050" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31172\" xsd:anyURI" ]

null

true

1

GO:0000054

54

ribosomal subunit export from nucleus

biological_process

The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.

[ "GOC:ai" ]

null

[ "ribosomal subunit export from cell nucleus", "ribosomal subunit export out of nucleus", "ribosomal subunit transport from nucleus to cytoplasm", "ribosomal subunit-nucleus export", "ribosome export from nucleus" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "RELATED" ]

[]

[ "goslim_yeast" ]

[]

[ "GO:0033750", "GO:0051168", "GO:0051656" ]

[ "part_of GO:0042254" ]

[ "part_of" ]

[ "GO:0042254" ]

[ "GO:0033750", "GO:0042254", "GO:0051168", "GO:0051656" ]

[]

null

false

true

2

GO:0000055

55

ribosomal large subunit export from nucleus

biological_process

The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.

[ "GOC:mah" ]

null

[ "50S ribosomal subunit export from nucleus", "60S ribosomal subunit export from nucleus", "ribosomal large subunit export from cell nucleus", "ribosomal large subunit export out of nucleus", "ribosomal large subunit transport from nucleus to cytoplasm", "ribosomal large subunit-nucleus export" ]

[ "NARROW", "NARROW", "EXACT", "EXACT", "EXACT", "EXACT" ]

[ "GO:0000057" ]

[]

[ "GO:0000054" ]

[]

[ "GO:0000054" ]

[]

null

false

true

8

GO:0000056

56

ribosomal small subunit export from nucleus

biological_process

The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.

[ "GOC:mah" ]

null

[ "30S ribosomal subunit export from nucleus", "40S ribosomal subunit export from nucleus", "ribosomal small subunit export from cell nucleus", "ribosomal small subunit export out of nucleus", "ribosomal small subunit transport from nucleus to cytoplasm", "ribosomal small subunit-nucleus export" ]

[ "NARROW", "NARROW", "EXACT", "EXACT", "EXACT", "EXACT" ]

[ "GO:0000058" ]

[]

[ "GO:0000054" ]

[]

[ "GO:0000054" ]

[]

null

false

true

3

GO:0000059

59

obsolete protein import into nucleus, docking

biological_process

OBSOLETE. A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex.

[ "GOC:isa_complete", "GOC:mah", "PMID:14570049", "PMID:7878057", "PMID:9126736" ]

This term was made obsolete because the transient assembly is better captured as a protein-protein association, if at all.

[ "protein docking during protein import into nucleus", "protein docking during protein transport from cytoplasm to nucleus", "protein docking during protein-nucleus import", "protein transport from cytoplasm to nucleus, docking", "protein-nucleus import, docking" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

null

true

4

GO:0000060

60

obsolete protein import into nucleus, translocation

biological_process

OBSOLETE. A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.

[ "GOC:curators", "ISBN:0198506732", "PMID:14570049", "PMID:9126736" ]

This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used.

[ "protein import into cell nucleus, translocation", "protein translocation during protein import into nucleus", "protein translocation during protein transport from cytoplasm to nucleus", "protein translocation during protein-nucleus import", "protein transport from cytoplasm to nucleus, translocation", "p...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

null

true

6

GO:0000061

61

obsolete protein import into nucleus, substrate release

biological_process

OBSOLETE. A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex.

[ "GOC:mah", "PMID:14570049", "PMID:9126736", "PMID:9687515" ]

This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used.

[ "protein import into cell nucleus, substrate release", "protein substrate release during protein import into nucleus", "protein substrate release during protein transport from cytoplasm to nucleus", "protein substrate release during protein-nucleus import", "protein transport from cytoplasm to nucleus, subs...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

null

true

4

GO:0000062

62

fatty-acyl-CoA binding

molecular_function

Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.

[ "GOC:jl", "GOC:krc", "ISBN:0198506732" ]

null

[ "fatty-acyl binding", "fatty-acyl-coenzyme A binding" ]

[ "BROAD", "EXACT" ]

[]

[ "Reactome:R-HSA-8848247 \"ACBD4,5 bind MCFA-CoA and LCFA-CoA\"" ]

[ "GO:0120227", "GO:1901567" ]

[]

[ "GO:0120227", "GO:1901567" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19443\" xsd:anyURI" ]

null

false

true

7

GO:0000064

64

L-ornithine transmembrane transporter activity

molecular_function

Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "histidine/arginine/lysine/ornithine porter activity", "L-ornithine transporter activity" ]

[ "RELATED", "BROAD" ]

[]

[ "Reactome:R-HSA-70634 \"ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)\"", "Reactome:R-HSA-9956519 \"SLC25A15 variants don't translocate ornithine and citrulline\"" ]

[ "GO:0015179" ]

[ "part_of GO:1903352" ]

[ "part_of" ]

[ "GO:1903352" ]

[ "GO:0015179", "GO:1903352" ]

[]

null

false

true

7

GO:0000067

67

obsolete DNA replication and chromosome cycle

biological_process

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity.

[ "DNA replication and chromosome cycle" ]

[ "EXACT" ]

[]

[ "GO:0006260", "GO:0007059", "GO:0051276" ]

[]

null

true

6

GO:0000070

70

mitotic sister chromatid segregation

biological_process

The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morp...

[ "GOC:ai", "GOC:jl" ]

null

[ "mitotic chromosome segregation", "mitotic sister-chromatid adhesion release" ]

[ "EXACT", "NARROW" ]

[ "GO:0016359" ]

[ "goslim_pombe" ]

[ "Reactome:R-HSA-2500257 \"Resolution of Sister Chromatid Cohesion\"" ]

[ "GO:0000819", "GO:1903047" ]

[ "part_of GO:0140014" ]

[ "part_of" ]

[ "GO:0140014" ]

[ "GO:0000819", "GO:0140014", "GO:1903047" ]

[ "GO:0098813", "part_of GO:0140014" ]

[]

null

false

true

1

GO:0000072

72

obsolete M phase specific microtubule process

biological_process

OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle.

[ "GOC:mah" ]

This term was made obsolete because terms already exist for centrosome/spindle organization which would be more suitable for the existing annotations, and the phase could be captured as an annotation extension if necessary.

[ "M phase specific microtubule process", "M-phase specific microtubule process" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0007017" ]

[]

null

true

1

GO:0000073

73

initial mitotic spindle pole body separation

biological_process

The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel s...

[ "GOC:sgd_curators", "GOC:vw" ]

null

[]

[ "GO:0030475" ]

[]

[ "GO:0110100", "GO:1903047" ]

[ "part_of GO:0061804", "part_of GO:1905047" ]

[ "part_of", "part_of" ]

[ "GO:0061804", "GO:1905047" ]

[ "GO:0061804", "GO:0110100", "GO:1903047", "GO:1905047" ]

[]

null

false

true

9

GO:0000075

75

cell cycle checkpoint signaling

biological_process

A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.

[ "GOC:mtg_cell_cycle" ]

This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not pa...

[ "cell cycle checkpoint", "G1/S checkpoint", "G1/S transition checkpoint", "G2/M checkpoint", "G2/M transition checkpoint", "signal transduction involved in cell cycle checkpoint", "signal transduction involved in G2/M transition checkpoint" ]

[ "EXACT", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT", "EXACT" ]

[ "GO:0031576", "GO:0071779", "GO:0072395", "GO:0072404", "GO:0072407" ]

[ "gocheck_do_not_annotate" ]

[ "Reactome:R-HSA-69620 \"Cell Cycle Checkpoints\"", "Wikipedia:Cell_cycle_checkpoint" ]

[ "GO:0035556", "GO:1901988" ]

[]

[ "GO:0035556", "GO:1901988" ]

[ "GO:0035556", "negatively_regulates GO:0044770" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20935\" xsd:anyURI" ]

null

false

true

6

GO:0000076

76

DNA replication checkpoint signaling

biological_process

A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.

[ "GOC:curators", "GOC:rn", "PMID:11728327", "PMID:12537518" ]

null

[ "DNA replication checkpoint", "signal transduction involved in DNA replication checkpoint" ]

[ "EXACT", "EXACT" ]

[ "GO:0072437" ]

[]

[ "GO:0031570" ]

[]

[ "GO:0031570" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20935\" xsd:anyURI" ]

null

false

true

8

GO:0000077

77

DNA damage checkpoint signaling

biological_process

A signal transduction process that contributes to a DNA damage checkpoint.

[ "GOC:mah" ]

null

[ "DNA damage checkpoint", "DNA damage response, signal transduction resulting in cell cycle arrest", "signal transduction involved in DNA damage checkpoint" ]

[ "EXACT", "NARROW", "EXACT" ]

[ "GO:0072422" ]

[]

[ "Wikipedia:DNA_damage_checkpoint", "Wikipedia:Postreplication_checkpoint" ]

[ "GO:0031570", "GO:0042770" ]

[]

[ "GO:0031570", "GO:0042770" ]

[]

mah

2010-12-08T04:18:11Z

false

true

3

GO:0000078

78

obsolete cytokinesis after mitosis checkpoint

biological_process

OBSOLETE. A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis.

[ "GOC:mtg_cell_cycle" ]

The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning.

[ "cell morphogenesis checkpoint", "cell shape checkpoint" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0044878", "GO:0044879" ]

[]

null

true

6

GO:0000079

79

regulation of cyclin-dependent protein serine/threonine kinase activity

biological_process

Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

[ "GOC:curators", "GOC:pr" ]

null

[ "regulation of CDK activity", "regulation of cyclin-dependent protein kinase activity" ]

[ "EXACT", "BROAD" ]

[]

[ "gocheck_obsoletion_candidate" ]

[]

[ "GO:0071900" ]

[ "regulates GO:0004693" ]

[ "regulates" ]

[ "GO:0004693" ]

[ "GO:0004693", "GO:0071900" ]

[ "GO:0065007", "regulates GO:0004693" ]

[]

null

false

true

2

GO:0000080

80

mitotic G1 phase

biological_process

The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.

[ "GOC:mtg_cell_cycle" ]

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phas...

[ "G1 phase of mitotic cell cycle" ]

[ "EXACT" ]

[]

[ "gocheck_do_not_annotate" ]

[ "Reactome:R-HSA-69236 \"G1 Phase\"" ]

[ "GO:0051318" ]

[ "part_of GO:0051329" ]

[ "part_of" ]

[ "GO:0051329" ]

[ "GO:0051318", "GO:0051329" ]

[]

null

false

true

8

GO:0000082

82

G1/S transition of mitotic cell cycle

biological_process

The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S pha...

[ "GOC:mtg_cell_cycle" ]

null

[]

[ "Reactome:R-HSA-69206 \"G1/S Transition\"" ]

[ "GO:0044772", "GO:0044843" ]

[]

[ "GO:0044772", "GO:0044843" ]

[ "GO:0044843", "part_of GO:0000278" ]

[]

null

false

true

1

GO:0000083

83

obsolete regulation of transcription involved in G1/S transition of mitotic cell cycle

biological_process

OBSOLETE. Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.

[ "GOC:mtg_cell_cycle" ]

This term was obsoleted because it represents a GO-CAM model.

[]

[ "GO:0000082", "GO:0006357" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26002\" xsd:anyURI" ]

null

true

9

GO:0000084

84

mitotic S phase

biological_process

The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.

[ "GOC:mtg_cell_cycle" ]

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phas...

[ "S phase of mitotic cell cycle", "S-phase of mitotic cell cycle" ]

[ "EXACT", "EXACT" ]

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0051320" ]

[ "part_of GO:0051329" ]

[ "part_of" ]

[ "GO:0051329" ]

[ "GO:0051320", "GO:0051329" ]

[]

null

false

true

4

GO:0000086

86

G2/M transition of mitotic cell cycle

biological_process

The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated ...

[ "GOC:mtg_cell_cycle" ]

null

[ "mitotic G2/M transition" ]

[ "EXACT" ]

[]

[ "Reactome:R-HSA-69275 \"G2/M Transition\"" ]

[ "GO:0044772", "GO:0044839" ]

[]

[ "GO:0044772", "GO:0044839" ]

[ "GO:0044839", "part_of GO:0000278" ]

[]

null

false

true

7

GO:0000087

87

mitotic M phase

biological_process

A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.

[ "GOC:mtg_cell_cycle" ]

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phas...

[ "M phase of mitotic cell cycle", "M-phase of mitotic cell cycle" ]

[ "EXACT", "EXACT" ]

[]

[ "gocheck_do_not_annotate" ]

[ "Reactome:R-HSA-68886 \"M Phase\"" ]

[ "GO:0000279", "GO:0098763" ]

[]

[ "GO:0000279", "GO:0098763" ]

[ "GO:0000279", "happens_during GO:0000278" ]

[]

null

false

true

1

GO:0000088

88

mitotic prophase

biological_process

The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.

[ "GOC:mtg_cell_cycle" ]

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phas...

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0051324" ]

[ "part_of GO:0000087" ]

[ "part_of" ]

[ "GO:0000087" ]

[ "GO:0000087", "GO:0051324" ]

[]

null

false

true

9

GO:0000089

89

mitotic metaphase

biological_process

The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.

[ "GOC:mtg_cell_cycle" ]

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phas...

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0051323" ]

[ "part_of GO:0000087" ]

[ "part_of" ]

[ "GO:0000087" ]

[ "GO:0000087", "GO:0051323" ]

[]

null

false

true

6

GO:0000090

90

mitotic anaphase

biological_process

The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.

[ "GOC:mtg_cell_cycle" ]

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phas...

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0051322" ]

[ "part_of GO:0000087" ]

[ "part_of" ]

[ "GO:0000087" ]

[ "GO:0000087", "GO:0051322" ]

[]

null

false

true

9

GO:0000091

91

mitotic anaphase A

biological_process

The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis.

[ "GOC:mtg_cell_cycle" ]

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phas...

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0000090" ]

[]

[ "GO:0000090" ]

[]

null

false

true

9

GO:0000092

92

mitotic anaphase B

biological_process

The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis.

[ "GOC:mtg_cell_cycle" ]

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phas...

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0000090" ]

[]

[ "GO:0000090" ]

[]

null

false

true

1

GO:0000093

93

mitotic telophase

biological_process

The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.

[ "GOC:mtg_cell_cycle" ]

Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phas...

[]

[ "gocheck_do_not_annotate" ]

[]

[ "GO:0051326" ]

[ "part_of GO:0000087" ]

[ "part_of" ]

[ "GO:0000087" ]

[ "GO:0000087", "GO:0051326" ]

[]

null

false

true

7

GO:0000094

94

obsolete septin assembly and septum formation

biological_process

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:curators" ]

This term was made obsolete because it was not defined and the string name implied two separate processes.

[ "septin assembly and septum formation" ]

[ "EXACT" ]

[]

[ "GO:0000917", "GO:0000918", "GO:0000921" ]

[]

null

true

8

GO:0000095

95

S-adenosyl-L-methionine transmembrane transporter activity

molecular_function

Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

[ "GOC:ai" ]

null

[ "S-adenosyl methionine permease activity", "S-adenosyl methionine transporter activity", "S-adenosylmethionine permease activity", "S-adenosylmethionine transmembrane transporter activity", "S-adenosylmethionine transporter activity", "SAM transmembrane transporter activity" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "BROAD", "EXACT" ]

[ "GO:0015177" ]

[]

[ "Reactome:R-HSA-8855062 \"SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy\"" ]

[ "GO:1901682" ]

[ "part_of GO:1901962" ]

[ "part_of" ]

[ "GO:1901962" ]

[ "GO:1901682", "GO:1901962" ]

[]

null

false

true

7

GO:0000096

96

sulfur amino acid metabolic process

biological_process

The chemical reactions and pathways involving amino acids containing sulfur.

[ "GOC:curators" ]

null

[ "sulfur amino acid metabolism", "sulphur amino acid metabolic process", "sulphur amino acid metabolism" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "Reactome:R-HSA-1614635 \"Sulfur amino acid metabolism\"" ]

[ "GO:0006790", "GO:0019752" ]

[]

[ "GO:0006790", "GO:0019752" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31500\" xsd:anyURI" ]

null

false

true

1

GO:0000097

97

sulfur amino acid biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of amino acids containing sulfur.

[ "GOC:curators" ]

null

[ "sulfur amino acid anabolism", "sulfur amino acid biosynthesis", "sulfur amino acid formation", "sulfur amino acid synthesis", "sulphur amino acid biosynthesis", "sulphur amino acid biosynthetic process" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0000096", "GO:0044272", "GO:0046394" ]

[]

[ "GO:0000096", "GO:0044272", "GO:0046394" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31500\" xsd:anyURI" ]

null

false

true

2

GO:0000098

98

sulfur amino acid catabolic process

biological_process

The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur.

[ "GOC:curators" ]

null

[ "sulfur amino acid breakdown", "sulfur amino acid catabolism", "sulfur amino acid degradation", "sulphur amino acid catabolic process", "sulphur amino acid catabolism" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "Reactome:R-HSA-1614558 \"Degradation of cysteine and homocysteine\"" ]

[ "GO:0000096", "GO:0044273", "GO:0046395" ]

[]

[ "GO:0000096", "GO:0044273", "GO:0046395" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31500\" xsd:anyURI" ]

null

false

true

7

GO:0000099

99

sulfur amino acid transmembrane transporter activity

molecular_function

Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives.

[ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]

null

[ "sulfur amino acid transporter activity", "sulphur amino acid transmembrane transporter activity", "sulphur amino acid transporter activity" ]

[ "BROAD", "EXACT", "BROAD" ]

[]

[ "GO:0046943", "GO:1901682" ]

[]

[ "GO:0046943", "GO:1901682" ]

[]

null

false

true

6

GO:0000101

101

sulfur amino acid transport

biological_process

The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

[ "GOC:ai" ]

null

[ "sulphur amino acid transport" ]

[ "EXACT" ]

[]

[ "GO:0046942", "GO:0071705", "GO:0072348" ]

[]

[ "GO:0046942", "GO:0071705", "GO:0072348" ]

[]

null

false

true

6

GO:0000104

104

succinate dehydrogenase activity

molecular_function

Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.

[ "RHEA:16357" ]

null

[ "fumarate dehydrogenase activity", "fumarate reductase activity", "fumaric hydrogenase activity", "succinate oxidoreductase activity", "succinic acid dehydrogenase activity", "succinic dehydrogenase activity", "succinodehydrogenase activity", "succinyl dehydrogenase activity" ]

[ "EXACT", "EXACT", "RELATED", "EXACT", "EXACT", "BROAD", "EXACT", "EXACT" ]

[ "GO:0019739" ]

[]

[ "KEGG_REACTION:R00412", "RHEA:16357", "RHEA:51848" ]

[ "GO:0016627" ]

[]

[ "GO:0016627" ]

[]

[ "skos:exactMatch RHEA:16357", "skos:narrowMatch RHEA:51848", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17091\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0000105

105

L-histidine biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

[ "GOC:curators" ]

null

[ "histidine anabolism", "histidine biosynthesis", "histidine biosynthetic process", "histidine formation", "histidine synthesis" ]

[ "EXACT", "EXACT", "BROAD", "EXACT", "EXACT" ]

[]

[ "MetaCyc:HISTSYN-PWY", "MetaCyc:PWY-5029" ]

[ "GO:0009073", "GO:0052803", "GO:0170034", "GO:0170038" ]

[]

[ "GO:0009073", "GO:0052803", "GO:0170034", "GO:0170038" ]

[]

[ "skos:narrowMatch MetaCyc:HISTSYN-PWY", "skos:narrowMatch MetaCyc:PWY-5029", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31525\" xsd:anyURI" ]

null

false

true

4

GO:0000107

107

imidazoleglycerol-phosphate synthase activity

molecular_function

Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+.

[ "RHEA:24793" ]

null

[ "glutamine amidotransferase:cyclase activity", "imidazole glycerol phosphate synthase activity", "imidazole-glycerol-phosphate synthase activity", "imidazoleglycerol phosphate synthase activity" ]

[ "BROAD", "EXACT", "RELATED", "EXACT" ]

[]

[ "MetaCyc:GLUTAMIDOTRANS-RXN", "RHEA:24793" ]

[ "GO:0016763" ]

[]

[ "GO:0016763" ]

[]

[ "skos:exactMatch RHEA:24793", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

2

GO:0000108

108

obsolete repairosome

cellular_component

OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides...

[ "PMID:10681587", "PMID:9852079" ]

This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators.

[ "repairosome" ]

[ "EXACT" ]

[]

[ "GO:0000109" ]

[]

null

true

2

GO:0000109

109

nucleotide-excision repair complex

cellular_component

Any complex formed of proteins that act in nucleotide-excision repair.

[ "PMID:10915862" ]

Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex.

[ "UvrB-UvrC complex", "UvrBC complex" ]

[ "NARROW", "NARROW" ]

[]

[ "goslim_pir" ]

[]

[ "GO:0140513" ]

[]

[ "GO:0140513" ]

[]

null

false

true

7

GO:0000110

110

nucleotide-excision repair factor 1 complex

cellular_component

One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.

[ "PMID:10915862" ]

Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.

[ "NEF1 complex", "XPA-ERCC1-ERCC4 complex" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0000109" ]

[]

[ "GO:0000109" ]

[]

null

false

true

6

GO:0000111

111

nucleotide-excision repair factor 2 complex

cellular_component

One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.

[ "PMID:10915862" ]

Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.

[ "NEF2 complex" ]

[ "EXACT" ]

[]

[ "GO:0000109" ]

[]

[ "GO:0000109" ]

[]

null

false

true

1

GO:0000112

112

nucleotide-excision repair factor 3 complex

cellular_component

One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).

[ "GOC:ew", "PMID:10915862", "PMID:14500720", "PMID:7813015" ]

Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.

[ "NEF3 complex" ]

[ "EXACT" ]

[]

[ "GO:0000109" ]

[ "has_part GO:0000439" ]

[ "has_part" ]

[ "GO:0000439" ]

[ "GO:0000109", "GO:0000439" ]

[]

null

false

true

6

GO:0000113

113

nucleotide-excision repair factor 4 complex

cellular_component

One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p.

[ "PMID:10915862" ]

Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.

[ "NEF4 complex" ]

[ "EXACT" ]

[]

[ "GO:0000109" ]

[]

[ "GO:0000109" ]

[]

null

false

true

9

GO:0000114

114

obsolete regulation of transcription involved in G1 phase of mitotic cell cycle

biological_process

OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle.

[ "GOC:dph", "GOC:mah", "GOC:tb" ]

This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.

[ "G1-specific transcription in mitotic cell cycle", "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle", "regulation of transcription involved in G1 phase of mitotic cell cycle" ]

[ "RELATED", "EXACT", "EXACT" ]

[]

[ "GO:0006357" ]

[]

null

true

6

GO:0000115

115

obsolete regulation of transcription involved in S phase of mitotic cell cycle

biological_process

OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle.

[ "GOC:dph", "GOC:mah", "GOC:tb" ]

This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.

[ "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle", "regulation of transcription involved in S phase of mitotic cell cycle", "regulation of transcription involved in S-phase of mitotic cell cycle", "S-phase-specific transcription in mitotic cell cycle", "S-spe...

[ "RELATED", "EXACT", "EXACT", "RELATED", "EXACT" ]

[]

[ "GO:0006357" ]

[]

null

true

2

GO:0000116

116

obsolete regulation of transcription involved in G2-phase of mitotic cell cycle

biological_process

OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle.

[ "GOC:dph", "GOC:mah", "GOC:tb" ]

This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'.

[ "G2-specific transcription in mitotic cell cycle", "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle", "regulation of transcription involved in G2-phase of mitotic cell cycle" ]

[ "RELATED", "RELATED", "EXACT" ]

[]

[ "GO:0006357" ]

[]

null

true

8

GO:0000118

118

histone deacetylase complex

cellular_component

A protein complex that possesses histone deacetylase activity.

[ "GOC:mah" ]

Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'.

[ "HDAC complex" ]

[ "EXACT" ]

[]

[ "GO:0140513", "GO:1902494" ]

[ "part_of GO:0005654" ]

[ "part_of" ]

[ "GO:0005654" ]

[ "GO:0005654", "GO:0140513", "GO:1902494" ]

[]

null

false

true

9

GO:0000120

120

RNA polymerase I transcription regulator complex

cellular_component

A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I.

[ "GOC:mah" ]

null

[ "RNA polymerase I transcription factor complex" ]

[ "NARROW" ]

[]

[ "GO:0005667", "GO:0140513" ]

[ "part_of GO:0005730" ]

[ "part_of" ]

[ "GO:0005730" ]

[ "GO:0005667", "GO:0005730", "GO:0140513" ]

[]

null

false

true

5

GO:0000122

122

negative regulation of transcription by RNA polymerase II

biological_process

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

[ "GOC:curators", "GOC:txnOH" ]

null

[ "down regulation of global transcription from RNA polymerase II promoter", "down regulation of transcription from RNA polymerase II promoter", "down-regulation of global transcription from RNA polymerase II promoter", "down-regulation of transcription from RNA polymerase II promoter", "downregulation of glo...

[ "RELATED", "EXACT", "RELATED", "EXACT", "RELATED", "EXACT", "RELATED", "EXACT", "RELATED", "RELATED", "EXACT", "EXACT", "RELATED" ]

[ "GO:0010553", "GO:0045816" ]

[]

[ "Reactome:R-HSA-2173795 \"Downregulation of SMAD2/3:SMAD4 transcriptional activity\"", "Reactome:R-HSA-8866904 \"Negative regulation of activity of TFAP2 (AP-2) family transcription factors\"" ]

[ "GO:0006357", "GO:0045892" ]

[ "negatively_regulates GO:0006366" ]

[ "negatively_regulates" ]

[ "GO:0006366" ]

[ "GO:0006357", "GO:0006366", "GO:0045892" ]

[ "GO:0065007", "negatively_regulates GO:0006366" ]

[]

null

false

true

5

GO:0000123

123

histone acetyltransferase complex

cellular_component

A protein complex that possesses histone acetyltransferase activity.

[ "GOC:mah" ]

Note that this term represents a protein complex, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:000440...

[ "histone acetylase complex" ]

[ "EXACT" ]

[]

[ "GO:0031248" ]

[ "part_of GO:0000785" ]

[ "part_of" ]

[ "GO:0000785" ]

[ "GO:0000785", "GO:0031248" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23892\" xsd:anyURI" ]

null

false

true

7

GO:0000124

124

SAGA complex

cellular_component

A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment facto...

[ "PMID:10637607", "PMID:17337012", "PMID:19056896", "PMID:20838651", "PMID:33004486" ]

null

[ "PCAF complex", "PCAF histone acetylase-associated complex", "Spt-Ada-Gcn5-acetyltransferase complex", "SPT3-TAF9-GCN5 acetylase complex", "SPT3-TAF9-PCAF acetylase complex", "STAGA coactivator complex", "STAGA complex" ]

[ "NARROW", "NARROW", "EXACT", "RELATED", "NARROW", "RELATED", "RELATED" ]

[ "GO:0000125", "GO:0030914" ]

[]

[ "GO:0070461", "GO:1905368" ]

[ "has_part GO:0071819" ]

[ "has_part" ]

[ "GO:0071819" ]

[ "GO:0070461", "GO:0071819", "GO:1905368" ]

[]

null

false

true

6

GO:0000126

126

transcription factor TFIIIB complex

cellular_component

A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF.

[ "GOC:mah", "PMID:11433012" ]

null

[]

[ "GO:0090576" ]

[]

[ "GO:0090576" ]

[]

null

false

true

4

GO:0000127

127

transcription factor TFIIIC complex

cellular_component

A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the prom...

[ "GOC:mah", "GOC:vw", "PMID:11433012", "PMID:16751097" ]

null

[]

[ "GO:0090576" ]

[]

[ "GO:0090576" ]

[]

null

false

true

4

GO:0000131

131

incipient cellular bud site

cellular_component

The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.

[ "GOC:clt" ]

null

[]

[ "GO:0030427" ]

[]

[ "GO:0030427" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27422\" xsd:anyURI" ]

null

false

true

8

GO:0000132

132

establishment of mitotic spindle orientation

biological_process

A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.

[ "GOC:ems" ]

null

[ "establishment of spindle orientation during mitosis", "establishment of spindle orientation involved in mitotic cell cycle", "mitotic spindle orientation", "orienting of mitotic spindle" ]

[ "RELATED", "EXACT", "EXACT", "EXACT" ]

[ "GO:0030607", "GO:0030609" ]

[]

[ "GO:0040001", "GO:0051294" ]

[]

[ "GO:0040001", "GO:0051294" ]

[ "GO:0051294", "part_of GO:0000278" ]

[]

null

false

true

4

GO:0000133

133

polarisome

cellular_component

Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.

[ "PMID:14734532", "PMID:14998522", "PMID:9632790" ]

null

[]

[ "goslim_pir" ]

[]

[ "GO:0032991" ]

[ "part_of GO:0005938", "part_of GO:0030427" ]

[ "part_of", "part_of" ]

[ "GO:0005938", "GO:0030427" ]

[ "GO:0005938", "GO:0030427", "GO:0032991" ]

[]

null

false

true

3

GO:0000136

136

mannan polymerase complex

cellular_component

A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins.

[ "GOC:mcc", "PMID:10037752", "PMID:11095735", "PMID:18083825" ]

null

[ "alpha-1,6-mannosyltransferase complex" ]

[ "EXACT" ]

[]

[ "GO:0031501", "GO:0098796" ]

[ "part_of GO:0000137", "part_of GO:0000139" ]

[ "part_of", "part_of" ]

[ "GO:0000137", "GO:0000139" ]

[ "GO:0000137", "GO:0000139", "GO:0031501", "GO:0098796" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19817\" xsd:anyURI" ]

null

false

true

6

GO:0000137

137

Golgi cis cisterna

cellular_component

The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.

[ "ISBN:0815316194" ]

null

[ "Golgi apparatus cis cisterna" ]

[ "EXACT" ]

[]

[ "GO:0031985" ]

[]

[ "GO:0031985" ]

[]

null

false

true

5